Sample records for edition including supplements

  1. NASA Thesaurus Supplement: A three part cumulative supplement to the 1982 edition of the NASA Thesaurus (supplement 2)

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The three part cumulative NASA Thesaurus Supplement to the 1982 edition of the NASA Thesaurus includes: part 1, hierarchical listing; part 2, access vocabulary, and part 3, deletions. The semiannual supplement gives complete hierarchies for new terms and includes new term indications for terms new to this supplement.

  2. NASA Thesaurus Supplement: A three part cumulative supplement to the 1982 edition of the NASA Thesaurus (supplement 3)

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The three part cumulative NASA Thesaurus Supplement to the 1982 edition of the NASA Thesaurus includes Part 1, Hierarchical Listing, Part 2, Access Vocabulary, and Part 3, Deletions. The semiannual supplement gives complete hierarchies for new terms and includes new term indications for entries new to this supplement.

  3. NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus. Supplement 4

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every six months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

  4. NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus. Supplement 5

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every 6 months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition of the NASA Thesaurus. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

  5. NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus. Supplement 7

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every six months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition of the NASA Thesaurus. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

  6. NASA Thesaurus supplement: A four part cumulative supplement to the 1988 edition of the NASA Thesaurus (supplement 3)

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The four-part cumulative supplement to the 1988 edition of the NASA Thesaurus includes the Hierarchical Listing (Part 1), Access Vocabulary (Part 2), Definitions (Part 3), and Changes (Part 4). The semiannual supplement gives complete hierarchies and accepted upper/lowercase forms for new terms.

  7. NASA Thesaurus Supplement: A Three-Part Cumulative Update of the 1998 Edition of the NASA Thesaurus

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The NASA Thesaurus Supplement is a cumulative update to the 1998 edition of the NASA Thesaurus (NASA/SP-1998-7501). The Supplement, published every six months, includes all new terms and associated hierarchies added since the cutoff for the 1998 edition (December 1997). Parts 1 and 2 (Hierarchical Listing and Rotated Term Display) correspond to Volumes 1 and 2 of the 1998 printed edition of the NASA Thesaurus. Definitions are included in Part 1; uppercase/lowercase forms are provided in both Parts 1 and 2. Part 3 is a list of deletions or changes to valid terms.

  8. The Law of Higher Education, 1997 Supplement. Third Edition.

    ERIC Educational Resources Information Center

    Kaplin, William A.; Lee, Barbara A.

    This 1997 supplement to "The Law of Higher Education: A Comprehensive Guide to Lead Implications of Administrative Decision Making, Third Edition" (1995) (ED 383 256), includes discussions of court opinions, statutes, regulations, and related developments, and cites selected law journal articles, books, and other resources concerning the legal…

  9. Evaluating Supplemental Educational Service Providers: Suggested Strategies for States. A Guidebook Prepared for the Center on Innovation & Improvement. Second Edition

    ERIC Educational Resources Information Center

    Ross, Steven M.; Potter, Allison; Harmon, Jennifer

    2006-01-01

    This second edition of the Guidebook is designed to help state educational agencies (SEAs) create an effective system to evaluate state-approved supplemental educational service (SES) providers. The text includes tools and strategies that will help readers determine evaluation measures, identify possible evaluation methodologies, and address the…

  10. Forty-first supplement to the American Ornithologists' Union Check-list of North American birds

    USGS Publications Warehouse

    Banks, R.C.; Fitzpatrick, J.W.; Howell, T.R.; Johnson, N.K.; Monroe, B.L.; Ouellet, H.; Remsen, J.V.; Storer, R.W.

    1997-01-01

    This seventh supplement after the publication of the 6th edition (1983) of the AOU Check-list of North American Birds includes taxonomic and nomenclatural changes adopted by the Committee on Classification and Nomenclature between 15 March 1995 and 15 March 1997. Because this will be the last supplement before the publication of the 7th edition of the Check-list, it also summarizes other decisions made by the Committee since 1983 that were not intended to affect the 6th edition but rather were to lay the foundation for its successor. Most of those decisions relate to sequence or rank of certain taxonomic categories. The Committee believes that compendia such as the Check-list are not appropriate places for the first appearance of novel taxonomic treatments or rearrangements. Therefore, we take the opportunity of this supplement to inform you of the ways in which the 7th edition will differ from the 6th. The style of this supplement differs from that of the previous six because they were designed to provide detailed changes to the text in the 6th edition; this one also is to provide information on how the 7th edition will differ from the 6th. Many details on reasons for the change will be discussed in the Preface or text of the new volume.

  11. Far infrared supplement: Catalog of infrared observations, second edition

    NASA Technical Reports Server (NTRS)

    Gezari, Daniel Y.; Schmitz, Marion; Mead, Jaylee M.

    1988-01-01

    The Far Infrared Supplement: Catalog of Infrared Observations summarizes all infrared astronomical observations at far infrared wavelengths (5 to 1000 microns) published in the scientific literature from 1965 through 1986. The Supplement list contain 25 percent of the observations in the full Catalog of Infrared Observations (CIO), and essentially eliminates most visible stars from the listings. The Supplement is thus more compact than the main catalog, and is intended for easy reference during astronomical observations. The Far Infrared Supplement (2nd Edition) includes the Index of Infrared Source Positions and the Bibliography of Infrared Astronomy for the subset of far infrared observations listed.

  12. Federal Student Assistance and Categorical Programs. 1981 Edition.

    ERIC Educational Resources Information Center

    Balz, Frank J.

    The fourth edition of analyses of selected federal student assistance and categorical programs prepared by the National Institute of Independent Colleges and Universities is presented. Sections include: (1) federal student assistance--undergraduate programs (Pell Grants, Supplemental Educational Opportunity Grants, State Student Incentive Grants,…

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yesley, M.S.; Ossorio, P.N.

    This report updates and expands the second edition of the ELSI Bibliography, published in 1993. The Bibliography and Supplement provides a comprehensive resource for identifying publications on the major topics related to the ethical, legal and social issues (ELSI) of the Human Genome Project. The Bibliography and Supplement are extracted from a database compiled at Los Alamos National Laboratory with the support of the Office of Energy Research, US Department of Energy. The second edition of the ELSI Bibliography was dated May 1993 but included publications added to the database until fall 1993. This Supplement reflects approximately 1,000 entries addedmore » to the database during the past year, bringing the total to approximately 7,000 entries. More than half of the new entries were published in the last year, and the remainder are earlier publications not previously included in the database. Most of the new entries were published in the academic and professional literature. The remainder are press reports from newspapers of record and scientific journals. The topical listing of the second edition has been followed in the Supplement, with a few changes. The topics of Cystic Fibrosis, Huntington`s Disease, and Sickle Cell Anemia have been combined in a single topic, Disorders. Also, all the entries published in the past year are included in a new topic, Publications: September 1993--September 1994, which provides a comprehensive view of recent reporting and commentary on the science and ELSI of genetics.« less

  14. Explanatory Supplement to the Astronomical Almanac, Third Edition

    NASA Astrophysics Data System (ADS)

    Seidelmann, P. Kenneth; Urban, S. E.

    2010-01-01

    "The Explanatory Supplement to the Astronomical Almanac" (hereafter "The Explanatory Supplement") is a comprehensive reference book on the topic of positional astronomy, covering the theories and algorithms used to produce "The Astronomical Almanac" (AsA), an annual publication produced jointly by the Nautical Almanac Office of the US Naval Observatory (USNO) and Her Majesty's Nautical Almanac Office (HMNAO) of the UK Hydrographic Office. The first edition of The Explanatory Supplement appeared in 1961 and was reprinted with amendments during the 1970s. The second edition was printed in 1992 and reprinted until 2006. Since the second edition, several changes have taken place in positional astronomy regarding reference systems and internationally accepted models, data sets, and computational methods; these have been incorporated into the AsA. Additionally, the data presented in the AsA have been modified over the years, with new tables being added and some being discontinued. Given these changes, a new edition of The Explanatory Supplement is appropriate. The third edition has been in development for the last few years and will be available in 2010. The book is organized similarly to the second (1991) edition, with each chapter written by subject matter experts. Authors from USNO and HMNAO contributed to the majority of the book, but there are authors from Jet Propulsion Laboratory, Technical University of Dresden, National Geospatial-Intelligence Agency, University of Texas Austin, and University of Virginia. This paper will discuss this latest edition of the Explanatory Supplement.

  15. Far infrared supplement. Third edition: Catalog of infrared observations (lambda greater than or equal to 4.6 micrometers)

    NASA Technical Reports Server (NTRS)

    Gezari, Daniel Y.; Schmitz, Marion; Pitts, Patricia S.; Mead, Jaylee M.

    1993-01-01

    The Far Infrared Supplement contains a subset of the data in the full Catalog of Infrared Observations (all observations at wavelengths greater than 4.6 microns). The Catalog of Infrared Observations (CIO), NASA RP-1294, is a compilation of infrared astronomical observational data obtained from an extensive literature search of scientific journals and major astronomical catalogs and surveys. The literature search is complete for years 1965 through 1990 in this third edition. The catalog contains about 210,000 observations of roughly 20,000 individual sources, and supporting appendices. The expanded third edition contains coded IRAS 4-band data for all CIO sources detected by IRAS. The appendices include an atlas of infrared source positions (also included in this volume), two bibliographies of catalog listings, and an atlas of infrared spectral ranges. The complete CIO database is available to qualified users in printed, microfiche, and magnetic tape formats.

  16. Asia: A Guide to Paperbacks. Revised Edition.

    ERIC Educational Resources Information Center

    Embree, Ainslie T., Ed.

    The guide includes in-print titles which were listed in the original guide and the supplement, new titles which appeared between December 1965 and December 1967, books published in 1968 provided by some publishers, and a few titles omitted from earlier editions. All the books are listed alphabetically by author within five subject areas:…

  17. ASIA A Guide to Paperbacks. Revised Edition.

    ERIC Educational Resources Information Center

    Embree, Ainslie T., Ed.

    The guide includes in-print titles which were listed in the original guide and the supplement, new titles which appeared between December 1965 and December 1967, books published in 1968 provided by some publishers, and a few titles omitted from earlier editions. All the books are listed alphabetically by author within five subject areas:…

  18. Safety in Science for Primary Schools. 1st Edition.

    ERIC Educational Resources Information Center

    Association for Science Education, Cambridge (England).

    This packet of teacher education materials is based on the publication "Be Safe!" and is intended for those teaching science to children ages 4 to 12. The pack contains INSET materials that supplement a safety exhibition contained in the second edition of "Be Safe!." Five basic activities include instructions for training…

  19. K-12 Resources on the Internet PLUS: Instructor's Supplement. 2nd Edition.

    ERIC Educational Resources Information Center

    Junion-Metz, Gail

    This volume is a supplement to "K-12 Resources on the Internet: An Instructional Guide" and is intended for teaching trainers that prepare Internet workshops in schools and libraries. It includes the following materials: guidelines on how to use this supplement together with the Instructional Guide in preparing a workshop; tips on how to use the…

  20. 1980 Cumulative Supplement, "Higher Education and the Law".

    ERIC Educational Resources Information Center

    Edwards, Harry T.; Nordin, Virginia Davis

    A 1980 cumulative supplement to the basic text, "Higher Education and the Law," is presented. Contents include: edited reports of five United States Supreme Court cases, important lower court cases, regulations and reports; and citations to numerous law review articles, additional cases, and other secondary sources. The following broad…

  1. Biological Science: An Ecological Approach. BSCS Green Version. Teacher's Resource Book and Test Item Bank. Sixth Edition.

    ERIC Educational Resources Information Center

    Biological Sciences Curriculum Study, Colorado Springs.

    This book consists of four sections: (1) "Supplemental Materials"; (2) "Supplemental Investigations"; (3) "Test Item Bank"; and (4) "Blackline Masters." The first section provides additional background material related to selected chapters and investigations in the student book. Included are a periodic table of the elements, genetics problems and…

  2. Selected Reference Books of 1979-80.

    ERIC Educational Resources Information Center

    Sheehy, Eugene P.

    1981-01-01

    Presents book reviews of recently published scholarly and general works of interest to reference workers in university libraries. The listing includes a brief roundup of new editions of standard works, continuations, and supplements. (RAA)

  3. Explanatory Supplement to the Astronomical Almanac (3rd Edition)

    NASA Astrophysics Data System (ADS)

    Urban, Sean E.; Seidelmann, P. K.

    2014-01-01

    Publications and software from the the Astronomical Applications Department of the US Naval Observatory (USNO) are used throughout the world, not only in the Department of Defense for safe navigation, but by many people including other navigators, astronomers, aerospace engineers, and geodesists. Products such as The Nautical Almanac, The Astronomical Almanac, and the Multiyear Interactive Computer Almanac (MICA) are regarded as international standards. To maintain credibility, it is imperative that the methodologies employed and the data used are well documented. "The Explanatory Supplement to the Astronomical Almanac" (hereafter, "The ES") is a major source of such documentation. It is a comprehensive reference book on positional astronomy, covering the theories and algorithms used to produce The Astronomical Almanac, an annual publication produced jointly by the Nautical Almanac Office of USNO and Her Majesty's Nautical Almanac Office (HMNAO). The first edition of The ES appeared in 1961, and the second followed in 1992. Several major changes have taken place in fundamental astronomy since the second edition was published. Advances in radio observations allowed the celestial reference frame to be tied to extragalactic radio sources, thus the International Celestial Reference System replaced the FK5 system. The success of ESA's Hipparcos satellite dramatically altered observational astrometry. Improvements in Earth orientation observations lead to new precession and nutation theories. Additionally, a new positional paradigm, no longer tied to the ecliptic and equinox, was accepted. Largely because of these changes, staff at USNO and HMNAO decided the time was right for the next edition of The ES. The third edition is now available; it is a complete revision of the 1992 book. Along with subjects covered in the previous two editions, the book also contains descriptions of the major advancements in positional astronomy over the last 20 years, some of which are described above. Extensive references to online information are given. This paper will discuss this latest edition of the Explanatory Supplement.

  4. Materials data handbook: Aluminum alloy 2014, 2nd edition

    NASA Technical Reports Server (NTRS)

    Muraca, R. F.; Whittick, J. S.

    1972-01-01

    A revised edition of the materials data handbook on the aluminum alloy 2014 is presented. The scope of the information presented includes physical and mechanical property data at cryogenic, ambient and elevated temperatures, supplemented with useful information in such areas as material procurement, metallurgy of the alloy, corrosion, environmental effects, fabrication and joining techniques. Design data are presented, as available, and these data are complemented with information on the typical behavior of the alloy.

  5. 76 FR 58345 - Energy Conservation Program: Test Procedures for Residential Dishwashers, Dehumidifiers, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ...Where appropriate, the U.S. Department of Energy (DOE) has proposed to amend its test procedures for residential dishwashers, dehumidifiers, and conventional cooking products (which includes cooktops, ovens, and ranges) to include provisions for measuring standby mode and off mode energy consumption, as required by the Energy Independence and Security Act of 2007 (EISA 2007). These test procedure amendments would incorporate by reference certain provisions of the International Electrotechnical Commission (IEC) Standard 62301, ``Household electrical appliances--Measurement of standby power.'' Since publication of DOE's initial proposal in December 2010, the IEC has replaced the First Edition of this standard with the current Second Edition. This supplemental notice of proposed rulemaking proposes to incorporate the latest edition of IEC Standard 62301.

  6. Canadian Reference Sources 1980--A Selection.

    ERIC Educational Resources Information Center

    Ryder, Dorothy E.

    1981-01-01

    Provides a bibliography of 52 reference sources and 24 new editions and supplements, excluding annuals. Topics include science and technology, art, history, university courses, regional information, native languages, museums, law, geography, Canadian culture, dissertations, sports, antiques, botany, and a variety of directories. (CHC)

  7. A Guide to the Study of the United States of America. Representative Books Reflecting the Development of American Life and Thought. Supplement 1956-1965.

    ERIC Educational Resources Information Center

    Orr, Oliver H., Jr.; And Others

    This supplement to the 1960 edition of "A Guide to the Study of the United States of America" contains titles held by the Library of Congress that reflect the development of the United States and were published between 1956 and 1965. In some instances a few pre-1956 publications are entered. These include parts of series or multivolume…

  8. [Preliminary textual research on Zhijintang Sanctum re-revised version of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)].

    PubMed

    Zheng, Jinsheng

    2014-03-01

    The Zhijintang Sanctum version of the re-revised edition of Jinling edition of Ben cao gang mu (Compendium of Materia Medica)collected by Zhao Huiyuan of Baihe, Henan Province in 2008 was opted as one of the third batch of the National Directory of Rare Ancient Worksin 2010. On the second cover page (patent page), it is recorded as"Original Jiangxi version". However, it is investigated to find that most of its paper sheets were reprinted after the original Jinling version, only scores of paper sheets were supplemented block-printed, including the additional block-printed second preface and Li Jianyuan's submitted report of the Jiangxi version, the re-revised time of which should be after the Jiangxi edition, or 1603. The exact time can be determined only by checking it carefully against another Jinling re-revised version (the Sheyuantang Sanctum edition).

  9. Introduction to Agricultural Sales and Service. Teacher Edition.

    ERIC Educational Resources Information Center

    Kauer, Les

    This Oklahoma curriculum guide contains 12 units. Each instructional unit includes some or all of these components: performance objectives, suggested activities, basic academic skills taxonomy, handouts, information sheets, supplements, transparency masters, activity sheets, assignment sheets, assignment sheet answers, job sheets, practical tests,…

  10. Selected Reference Books of 1993-1994.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1994-01-01

    Offers brief, critical reviews of recent scholarly and general works of interest to reference workers in university libraries. Titles covered include dictionaries, databases, religion, literature, music, dance, art and architecture, business, political science, social issues, and history. Brief descriptions of new editions and supplements for…

  11. Learn, Grow, Become. TSA Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This revised curriculum guide contains five units that are designed to help students develop an understanding of the mission of the Technology Student Association (TSA). Each unit follows a standard format that includes some or all of these basic components: performance objectives, suggested activities, handouts, information sheets, supplements,…

  12. Aquaculture. Teacher Edition.

    ERIC Educational Resources Information Center

    Walker, Susan S.

    This color-coded guide was developed to assist teachers in helping interested students plan, build, stock, and run aquaculture facilities of varied sizes. The guide contains 15 instructional units, each of which includes some or all of the following basic components: objective sheet, suggested activities for the teacher, instructor supplements,…

  13. U.S. Government Films, 1971 Supplement; A Catalog of Audiovisual Materials for Rent and Sale by the National Audiovisual Center.

    ERIC Educational Resources Information Center

    National Archives and Records Service (GSA), Washington, DC. National Audiovisual Center.

    The first edition of the National Audiovisual Center sales catalog (LI 003875) is updated by this supplement. Changes in price and order number as well as deletions from the 1969 edition, are noted in this 1971 version. Purchase and rental information for the sound films and silent filmstrips is provided. The broad subject categories are:…

  14. Earth's Volcanoes and their Eruptions; the 3rd edition of the Smithsonian Institution's Volcanoes of the World

    NASA Astrophysics Data System (ADS)

    Siebert, L.; Simkin, T.; Kimberly, P.

    2010-12-01

    The 3rd edition of the Smithsonian Institution’s Volcanoes of the World incorporates data on the world’s volcanoes and their eruptions compiled since 1968 by the Institution’s Global Volcanism Program (GVP). Published this Fall jointly by the Smithsonian and the University of California Press, it supplements data from the 1994 2nd edition and includes new data on the number of people living in proximity to volcanoes, the dominant rock lithologies at each volcano, Holocene caldera-forming eruptions, and preliminary lists of Pleistocene volcanoes and large-volume Pleistocene eruptions. The 3rd edition contains data on nearly 1550 volcanoes of known or possible Holocene age, including chronologies, characteristics, and magnitudes for >10,400 Holocene eruptions. The standard 20 eruptive characteristics of the IAVCEI volcano catalog series have been modified to include dated vertical edifice collapse events due to magma chamber evacuation following large-volume explosive eruptions or mafic lava effusion, and lateral sector collapse. Data from previous editions of Volcanoes of the World are also supplemented by listings of up to the 5 most dominant lithologies at each volcano, along with data on population living within 5, 10, 30, and 100 km radii of each volcano or volcanic field. Population data indicate that the most populated regions also contain the most frequently active volcanoes. Eruption data document lava and tephra volumes and Volcanic Explosivity Index (VEI) assignments for >7800 eruptions. Interpretation of VRF data has led to documentation of global eruption rates and the power law relationship between magnitude and frequency of volcanic eruptions. Data with volcanic hazards implications include those on fatalities and evacuations and the rate at which eruptions reach their climax. In recognition of the hazards implications of potential resumption of activity at pre-Holocene volcanoes, the 3rd edition includes very preliminary lists of Pleistocene volcanoes and large-volume Pleistocene eruptions, the latter in collaboration with the VOGRIPA project of Steve Sparks and colleagues. The GVP volcano and eruption data derive both from the retrospective perspective of the volcanological and other literature and documentation of contemporary eruptions and volcanic unrest in the Smithsonian’s monthly bulletin and Weekly Volcanic Activity Reports compiled since 2000 in collaboration with the USGS.

  15. Mathematics and Living Things. Student Text. Revised Edition.

    ERIC Educational Resources Information Center

    Faber, Norman J.; And Others

    This document is designed for grade eight to enrich and supplement the usual courses of instruction. Mathematics and Living Things (MALT) utilizes exercises in biological science to derive data through which mathematical concepts and principles may be introduced and expanded. Chapters included are: (1) Leaves and Natural Variation: Measurement of…

  16. Terrorism: Supplement to the Second Edition. A Selected Bibliography.

    ERIC Educational Resources Information Center

    Boston, Guy D.

    The annotated bibliography describes 85 materials related to terrorism which were collected by the National Criminal Reference Service. Although no consensus exists on the definition of terrorism, the term is interpreted in this document to include both illegal and destructive acts against society and governments and violent means undertaken to…

  17. Pump Operation Workshop. Third Edition (Revised).

    ERIC Educational Resources Information Center

    Ontario Ministry of the Environment, Toronto.

    Presented is the learner's manual for a five-day workshop designed to supplement the skills of water and wastewater treatment personnel. The program consists of lecture-discussions and hands-on sessions covering the operation of water and wastewater pumps. Areas addressed include: material pumped, pump systems, types of pumps, pump controls,…

  18. Tape It Yourself: Videotapes for Teacher Education

    ERIC Educational Resources Information Center

    Ebsworth, Miriam Eistein; Feknous, Barbara; Loyet, Dianne; Zimmerman, Spencer

    2004-01-01

    This paper describes the development and implementation of a series of videotapes of ESL classes for a pre-service teacher education program grounded in experiential learning theory. The videos included footage of ESL classrooms, and tapes edited and supplemented with interviews of ESL teachers. Our experience demonstrates that-with relatively low…

  19. Catalog of Infrared Observations, Third Edition

    NASA Technical Reports Server (NTRS)

    Gezari, Daniel Y.; Schmitz, Marion; Pitts, Patricia S.; Mead, Jaylee M.

    1993-01-01

    The Far Infrared Supplement contains a subset of the data in the full Catalog of Infrared Observations (all observations at wavelengths greater than 4.6 microns). The Catalog of Infrared Observations (CIO), NASA RP-1294, is a compilation of infrared astronomical observational data obtained from an extensive literature search of scientific journals and major astronomical catalogs and surveys. The literature search is complete for years 1965 through 1990 in this Third Edition. The Catalog contains about 210,000 observations of roughly 20,000 individual sources and supporting appendices. The expanded Third Edition contains coded IRAS 4-band data for all CIO sources detected by IRAS. The appendices include an atlas of infrared source positions (also included in this volume), two bibliographies of Catalog listings, and an atlas of infrared spectral ranges. The complete CIO database is available to qualified users in printed, microfiche, and magnetic-tape formats.

  20. Bibliography of In-House and Contract Reports, Supplement 12.

    DTIC Science & Technology

    1984-03-01

    A134 952 Karow, Kenneth ADVANCE EDIT SYSTEM January 1983 Sonicraft, Inc. DAAK70-79-C-0 180 Keywords: Automated Cartography, Digital Data Editing...Interactive Graphics. An advanced edit system with high resolution interactive graphic workstations and support software for editing digital cartographic...J.R. OF INERTIAL SURVEY DATA Wei, S.Y. December 1982 Litton Guidance and Control Systems DAAK-70-81-C-0082 Keywords: Collocation, Gravity vector

  1. Advanced Dairy Unit for Advanced Livestock Production Curriculum. Selected Readings. AGDEX 410/00.

    ERIC Educational Resources Information Center

    Coday, Stan; Stewart, Bob R.

    These selected readings are designed to supplement James Gillespie's "Modern Livestock and Poultry Production" (2nd edition) as the the student reference for the advanced dairy unit. Readings are provided for 18 lessons. Topics include profitability of the dairy enterprise; production costs for dairy; comparative advantages of dairy; milk…

  2. Water Quality Instructional Resources Information System (IRIS): A Compilation of Abstracts to Water Quality and Water Resources Materials. Includes May 1979 edition and Supplements 1-15.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus, OH. Information Reference Center for Science, Mathematics, and Environmental Education.

    Compiled are abstracts and indexes to selected print and non-print materials related to wastewater treatment and water quality education and instruction, as well as materials related to pesticides, hazardous wastes, and public participation. Sources of abstracts/indexed materials include all levels of government, private concerns, and educational…

  3. The Belgian Union Catalogue of Periodicals

    ERIC Educational Resources Information Center

    Goedeme, G.; And Others

    1976-01-01

    Describes the edition, on computer output microfiche, of the supplement to the 1965 Union catalogue of foreign periodicals in Belgian and Luxemburgian libraries and documentation centers. The microfiches contain location information of 28,000 periodicals in 300 libraries and are edited in a rich typography. (Author)

  4. Practical Law in Utah, Second Edition. Utah Supplement to Street Law.

    ERIC Educational Resources Information Center

    Astin, Katherine, Ed.; And Others

    This guide on law education is designed for high school students. Objectives are to give a fundamental understanding of Utah law in those areas that may be encountered personally, show how laws are made, and explain what to do if you become involved with the law. This volume is arranged in seven chapters. Topics include: (1) an introduction to…

  5. Addendum to the Handbook of Accreditation. Second Edition.

    ERIC Educational Resources Information Center

    North Central Association of Colleges and Schools, Chicago, IL. Higher Learning Commission.

    This document supplements information provided in the "Handbook of Accreditation," Second Edition (Commission on Institutions of Higher Education). The Addendum contains the information necessary to keep readers informed of changes in policies and procedures while the Commission is engaged in an initiative to revise its Eligibility…

  6. IYA2009 newspaper insert in your community

    NASA Astrophysics Data System (ADS)

    Harvey, J.

    2008-06-01

    The Gemini PIO (Public Information Officer) offers suggestions on how to approach your local newspaper about a newspaper insert for your community being published during IYA2009. Local government support, articles by astronomers, advertisers, and appointing someone within your organisation to manage the content will be discussed. We will explain the timeline required, the number of personnel hours required, developmental stages and income a local newspaper would have to generate to produce a quality, table-top supplement. In 2003, over 30,000 copies of Stars over Mauna Kea, a special supplement in tabloid format were produced and distributed in the local newspapers in Hilo, Hawaii. The publication, 48 pages in total, featured profiles of the observatories on Mauna Kea, stories about the geology and legends of Mauna Kea, and historical information about the evolution of astronomy in Hawaii. In additionthe publication included a series of essays titled In their own words. These articles were written by key members of the astronomy community. Sixty thousand copies of Stars over Mauna Kea II were printed as a follow-up to the first edition in 2005. This second edition included an article on the `Imiloa Astronomy Education Center, explanations about the types of telescopes on Mauna Kea and columns written by scientists about the fascinating and significant discoveries made on Hawaii. Personal stories about careers in astronomy were also highlighted. In Chile, a similar eight-page supplement, featuring Gemini, CTIO and SOAR telescopes, was published in 2005 and 5000 copies were distributed throughout the country.

  7. The Assessment Supplement: A Faculty-Designed Addition to NCC's Manual, "Concepts & Procedures for Academic Assessment." First Edition.

    ERIC Educational Resources Information Center

    Nassau Community Coll., Garden City, NY.

    This document is the first in a series of annual, faculty-designed supplements to Nassau Community College's (NCC's) (New York) manual, "Concepts & Procedures for Academic Assessment." The supplements are intended to provide faculty a forum through which they can communicate assessment designs and the impacts of those designs on…

  8. America's Heritage: An Adventure in Liberty. Elementary Edition. First Edition.

    ERIC Educational Resources Information Center

    Houston Independent School District, TX.

    These curriculum materials are intended to supplement school resources for elementary school teachers as they deliver instruction. They focus on developing an understanding about the nation's factual and philosophical heritage to promote freedom, unity, progress, and responsibility among students and citizens. The resource points out that the…

  9. America's Heritage: An Adventure in Liberty. High School Edition. First Edition.

    ERIC Educational Resources Information Center

    Houston Independent School District, TX.

    These curriculum materials are intended to supplement classroom resources for teaching high school students the roots of U.S. heritage and the responsibilities of American citizenship. The materials are divided into 14 sections: (1) "Purpose"; (2) "Letter from Superintendent"; (3) "Forward: Miracle of America"; (4) "Preface: From Oppression to…

  10. America's Heritage: An Adventure in Liberty. Middle School Edition. First Edition.

    ERIC Educational Resources Information Center

    Houston Independent School District, TX.

    These curriculum materials are intended to supplement classroom resources for teaching middle school students about the roots of the nation's heritage and the responsibilities of U.S. citizenship. The materials are divided into 16 sections: (1) "Purpose"; (2) "Letter from Superintendent"; (3) "Forward: Miracle of America"; (4) "Preface: From…

  11. Guidelines for Health Services for Migrant Students. 1984 Edition.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Bureau of Community Services and Migrant Education.

    To promote uniformity and continuity, standards have been established for planning, implementing, and evaluating student health programs provided by grade K-12 migrant education programs throughout California. State mandated health requirements, the rationale for supplemental services, methods of providing supplemental services, and community…

  12. Journal of Special Operations Medicine. Volume 7, Edition 1, Winter 2007. Training Supplement: USSOCOM Medic Certification Program

    DTIC Science & Technology

    2007-01-01

    Complicated intra-abdominal infections Complicated skin infections Pneumonia Complicated UTI , including pyelonephritis Acute pelvic infections Drug of...nitroimidazole derivatives. Pregnancy (first trimester in patients with Trichomoniasis). Administer with caution to patients with CNS diseases. Use with caution...under 12 years Dehydration Use with caution in pregnancy . Dosage: Patient in shock, bleeding not controlled: hold fluid and control bleeding. Patient

  13. Detecting duplicate biological entities using Shortest Path Edit Distance.

    PubMed

    Rudniy, Alex; Song, Min; Geller, James

    2010-01-01

    Duplicate entity detection in biological data is an important research task. In this paper, we propose a novel and context-sensitive Shortest Path Edit Distance (SPED) extending and supplementing our previous work on Markov Random Field-based Edit Distance (MRFED). SPED transforms the edit distance computational problem to the calculation of the shortest path among two selected vertices of a graph. We produce several modifications of SPED by applying Levenshtein, arithmetic mean, histogram difference and TFIDF techniques to solve subtasks. We compare SPED performance to other well-known distance algorithms for biological entity matching. The experimental results show that SPED produces competitive outcomes.

  14. Fifty-eighth supplement to the American Ornithologists' Union: Check-list of North American Birds

    USGS Publications Warehouse

    Chesser, Terry; Burns, Kevin J; Cicero, Carla; Dunn, Jon L.; Kratter, Andrew W.; Lovette, Irby J.; Rasmussen, Pamela C.; Remsen, J.V.; Rising, James D.; Stotz, Douglas F.; Winker, Kevin

    2017-01-01

    This is the 17th supplement since publication of the 7th edition of the Check-list of North American Birds (American Ornithologists' Union [AOU] 1998). It summarizes decisions made between April 15, 2016, and April 15, 2017, by the AOS's Committee on Classification and Nomenclature—North and Middle America. The Committee has continued to operate in the manner outlined in the 42nd Supplement

  15. Science Education Supporting Weather Broadcasters On-Air and in the Classroom with NASA "Mini-Education Supplements"

    NASA Technical Reports Server (NTRS)

    Shepherd, J. Marshall; Starr, David OC. (Technical Monitor)

    2001-01-01

    NASA-Goddard Space Flight Center has initiated a new project designed to expand on existing news services and add value to classrooms through the development and distribution of two-minute 'mini-supplements' which give context and teach about current weather and Earth research phenomena. The innovative mini-supplements provide raw materials for weather forecasters to build news stories around NASA related missions without having to edit the more traditional and cumbersome long-form video format. The supplements cover different weather and climate topics and include NASA data, animations, video footage, and interviews with scientists. The supplements also include a curriculum package with educational lessons, educator guide, and hand-on activities. One goal is to give on-air broadcasters who are the primary science educators for the general public what they need to 'teach' about the science related to NASA research behind weather and climate news. This goal achieves increasing public literacy and assures higher accuracy and quality science reporting by the media. The other goal is to enable on-air broadcasters to serve as distributors of high quality, standards-based educational curricula and supplemental material when they visit 8-12 grade classrooms. The focus of 'pilot effort' centers around the success of NASA's Tropical Rainfall Measuring Mission (TRMM) but is likely expandable to other NASA earth or space science missions.

  16. Fifty-seventh supplement to the American Ornithologists' Union Check-list of North American Birds

    USGS Publications Warehouse

    Chesser, R. Terry; Burns, Kevin J; Cicero, Carla; Dunn, Jon L.; Kratter, Andrew W.; Lovette, Irby J.; Rasmussen, Pamela C.; Remsen, J.V.; Rising, James D.; Stotz, Douglas F.; Winker, Kevin

    2016-01-01

    This is the 16th supplement since publication of the 7th edition of the Check-list of North American Birds (American Ornithologists' Union [AOU] 1998). It summarizes decisions made between April 15, 2015, and April 15, 2016, by the AOU's Committee on Classification and Nomenclature—North and Middle America. The Committee has continued to operate in the manner outlined in the 42nd Supplement (AOU 2000).

  17. Fifty-sixth supplement to the American Ornithologists' Union: Check-list of North American Birds

    USGS Publications Warehouse

    Chesser, R. Terry; Banks, Richard C.; Burns, Kevin J; Cicero, Carla; Dunn, Jon L.; Kratter, Andrew W.; Lovette, Irby J.; Navarro-Siguenza, Adolfo G.; Rasmussen, Pamela C.; Remsen, J V; Rising, James D.; Stotz, Douglas F.; Winker, Kevin

    2015-01-01

    This is the 15th supplement since publication of the 7th edition of the Check-list of North American Birds (American Ornithologists' Union [AOU] 1998). It summarizes decisions made between May 15, 2014, and April 15, 2015, by the AOU's Committee on Classification and Nomenclature - North and Middle America. The Committee has continued to operate in the manner outlined in the 42nd Supplement (AOU 2000).

  18. Exotic objects of atomic physics

    NASA Astrophysics Data System (ADS)

    Eletskii, A. V.

    2017-11-01

    There has been presented a short survey of physical properties, methods of production and exploration as well as directions of practical usage of the objects of atomic physics which are not yet described in detail in modern textbooks and manuals intended for students of technical universities. The family of these objects includes negative and multicharged ions, Rydberg atoms, excimer molecules, clusters. Besides of that, in recent decades this family was supplemented with new nanocarbon structures such as fullerenes, carbon nanotubes and graphene. The textbook “Exotic objects of atomic physics” [1] edited recently contains some information on the above-listed objects of the atomic physics. This textbook can be considered as a supplement to classic courses of atomic physics teaching in technical universities.

  19. Breaking away from the Textbook: A Creative Approach to Teaching American History. Third Edition

    ERIC Educational Resources Information Center

    Kintisch, Shelly; Cordero, Wilma

    2005-01-01

    This "Third Edition" updates the decades of the 1980s and 1990s and moves into the events and issues of the 21st century. Designed as a teaching supplement for any U.S. history course of study, it can be used in its entirety or selectively to fill in gaps left by traditional textbooks and curricula. The authors seek to bring U.S. history…

  20. DNA EMP Awareness Course Notes. Supplement to Third Edition.

    DTIC Science & Technology

    1978-07-31

    UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered) REPORT DOCUMENTATION PAGE READ INSTRUCTIONS BEFORE COMPLETING FORM I REPORT...the environment through system design and testing. FORM 143 E,,N F’NOV 65 IS OBSOLETE DD JAN73 1473 EDITION OF UNCLASSIFIED SECURITY CLASSIFICATION OF...fields generated tems mission and deployment factors by the prompt gammas. Other forms of EMP, where these environments should be con- such as

  1. Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease

    PubMed Central

    Khermesh, Khen; D'Erchia, Anna Maria; Barak, Michal; Annese, Anita; Wachtel, Chaim; Levanon, Erez Y.; Picardi, Ernesto; Eisenberg, Eli

    2016-01-01

    Adenosine to inosine (A-to-I) RNA editing, catalyzed by the ADAR enzyme family, acts on dsRNA structures within pre-mRNA molecules. Editing of the coding part of the mRNA may lead to recoding, amino acid substitution in the resulting protein, possibly modifying its biochemical and biophysical properties. Altered RNA editing patterns have been observed in various neurological pathologies. Here, we present a comprehensive study of recoding by RNA editing in Alzheimer's disease (AD), the most common cause of irreversible dementia. We have used a targeted resequencing approach supplemented by a microfluidic-based high-throughput PCR coupled with next-generation sequencing to accurately quantify A-to-I RNA editing levels in a preselected set of target sites, mostly located within the coding sequence of synaptic genes. Overall, editing levels decreased in AD patients’ brain tissues, mainly in the hippocampus and to a lesser degree in the temporal and frontal lobes. Differential RNA editing levels were observed in 35 target sites within 22 genes. These results may shed light on a possible association between the neurodegenerative processes typical for AD and deficient RNA editing. PMID:26655226

  2. The Colleges and the Courts: The Developing Law of the Student and the College. 1976 Updating Supplement.

    ERIC Educational Resources Information Center

    Chambers, M. M.

    Constant progress and change in the law of higher education have necessitated this update of the original 1972 edition of this document (the original appeared with the same title) and its first updated supplement. Approximately 60 court decisions are cited that deal with students and their relationship to their colleges. Specific areas discussed…

  3. Practical Law in Utah. Utah Supplement to "Street Law." Fourth Edition.

    ERIC Educational Resources Information Center

    Utah State Office of Education, Salt Lake City. Statewide Clearinghouse on Law-Related Education.

    This textbook for high school students on law in Utah supplements "Street Law: A Course in Practical Law," a program in law-related education in use across the United States. The introduction explains the meaning of law, how laws are made in Utah, and the functions of the state court system. Following chapters elucidate the branches of…

  4. The WIC Program: Background, Trends, and Economic Issues, 2009 Edition. Economic Research Report Number 73

    ERIC Educational Resources Information Center

    Oliveira, Victor; Frazao, Elizabeth

    2009-01-01

    The mission of the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is to safeguard the health of low-income women, infants, and children through age 4 who are at nutritional risk. WIC provides nutritious foods to supplement diets, nutrition education, and referrals to health care and other social services.…

  5. Spacecraft Systems Engineering, 3rd Edition

    NASA Astrophysics Data System (ADS)

    Fortescue, Peter; Stark, John; Swinerd, Graham

    2003-03-01

    Following on from the hugely successful previous editions, the third edition of Spacecraft Systems Engineering incorporates the most recent technological advances in spacecraft and satellite engineering. With emphasis on recent developments in space activities, this new edition has been completely revised. Every chapter has been updated and rewritten by an expert engineer in the field, with emphasis on the bus rather than the payload. Encompassing the fundamentals of spacecraft engineering, the book begins with front-end system-level issues, such as environment, mission analysis and system engineering, and progresses to a detailed examination of subsystem elements which represent the core of spacecraft design - mechanical, electrical, propulsion, thermal, control etc. This quantitative treatment is supplemented by an appreciation of the interactions between the elements, which deeply influence the process of spacecraft systems design. In particular the revised text includes * A new chapter on small satellites engineering and applications which has been contributed by two internationally-recognised experts, with insights into small satellite systems engineering. * Additions to the mission analysis chapter, treating issues of aero-manouevring, constellation design and small body missions. In summary, this is an outstanding textbook for aerospace engineering and design students, and offers essential reading for spacecraft engineers, designers and research scientists. The comprehensive approach provides an invaluable resource to spacecraft manufacturers and agencies across the world.

  6. 11/12 F.L.A.S.H.: A Curriculum Supplement in Family Life and Sexual Health for Grades 11 & 12.

    ERIC Educational Resources Information Center

    Reis, Elizabeth

    This curriculum supplement is designed for high school juniors and seniors to augment the edition designed for freshmen and sophomores. The document is divided into 18 units. Unit 1 is on critical thinking, and serves to help the student distinguish among values, feelings, fallacies, and facts. The next five units are grouped together under child…

  7. Lessons from Africa: A Supplement to Middle School Courses in World Culture, Global Studies, and World Geography. Experimental Edition.

    ERIC Educational Resources Information Center

    Merryfield, Merry M., Ed.

    These lessons were written by African social studies specialists for U.S. middle school students to stimulate interest in and develop a positive attitude toward Africans and their culture. Each lesson provides objectives, materials, teaching procedures, and is meant to be used as a textbook supplement. To promote understanding of young Africans,…

  8. 21 CFR 701.3 - Designation of ingredients.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... purpose of cosmetic ingredient labeling, provided the respective monographs are revised to describe their... revised monographs are published in supplements to this dictionary edition by July 18, 1980. Acid Black 2...

  9. Impairment Rating Ambiguity in the United States: The Utah Impairment Guides for Calculating Workers' Compensation Impairments

    PubMed Central

    Hunter, Bradley; Bunkall, Larry D.; Holmes, Edward B.

    2009-01-01

    Since the implementation of workers' compensation, accurately and consistently rating impairment has been a concern for the employee and employer, as well as rating physicians. In an attempt to standardize and classify impairments, the American Medical Association (AMA) publishes the AMA Guides ("Guides"), and recently published its 6th edition of the AMA Guides. Common critiques of the AMA Guides 6th edition are that they are too complex, lacking in evidence-based methods, and rarely yield consistent ratings. Many states mandate use of some edition of the AMA Guides, but few states are adopting the current edition due to the increasing difficulty and frustration with their implementation. A clearer, simpler approach is needed. Some states have begun to develop their own supplemental guides to combat problems in complexity and validity. Likewise studies in Korea show that past methods for rating impairment are outdated and inconsistent, and call for measures to adapt current methods to Korea's specific needs. The Utah Supplemental Guides to the AMA Guides have been effective in increasing consistency in rating impairment. It is estimated that litigation of permanent impairment has fallen below 1% and Utah is now one of the least costly states for obtaining workers' compensation insurance, while maintaining a medical fee schedule above the national average. Utah's guides serve as a model for national or international impairment guides. PMID:19503678

  10. Combining pain therapy with lifestyle: the role of personalized nutrition and nutritional supplements according to the SIMPAR Feed Your Destiny approach.

    PubMed

    De Gregori, Manuela; Muscoli, Carolina; Schatman, Michael E; Stallone, Tiziana; Intelligente, Fabio; Rondanelli, Mariangela; Franceschi, Francesco; Arranz, Laura Isabel; Lorente-Cebrián, Silvia; Salamone, Maurizio; Ilari, Sara; Belfer, Inna; Allegri, Massimo

    2016-01-01

    Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, omega-3 fatty acids, and curcumin supplementation as key elements in modulating the efficacy of analgesic treatments, including opioids. These main topics were addressed during the first edition of the Study In Multidisciplinary Pain Research workshop: "FYD (Feed Your Destiny): Fighting Pain", held on April 7, 2016, in Rome, Italy, which was sponsored by a grant from the Italian Ministry of Instruction on "Nutraceuticals and Innovative Pharmacology". The take-home message of this workshop was the recognition that patients with chronic pain should undergo nutritional assessment and counseling, which should be initiated at the onset of treatment. Some foods and supplements used in personalized treatment will likely improve clinical outcomes of analgesic therapy and result in considerable improvement of patient compliance and quality of life. From our current perspective, the potential benefit of including nutrition in personalizing pain medicine is formidable and highly promising.

  11. Selected Reference Books of 1998-99.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1999-01-01

    Presents an annotated bibliography of selected reference books published between 1998 and 1999 under subject headings for biography, journalism, mythology, languages and literature, architecture and city planning, political science, economics, history, and new editions and supplements. (LRW)

  12. Selected Reference Books of 2000/2001.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    2002-01-01

    Presents an annotated list of selected recent scholarly and general reference works under the subject categories of archives; literature; music; psychology; sociology; black studies; women's studies; history and area studies; and new editions and supplements. (LRW)

  13. Supplement a to compilation of air pollutant emission factors. Volume 1. Stationary point and area sources. Fifth edition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-02-01

    This Supplement to AP-42 addresses pollutant-generating activity from Bituminous and Subbituminous Coal Combustion; Anthracite Coal Combustion; Fuel Oil Combustion; Natural Gas Combustion; Wood Waste Combustion in Boilers; Lignite Combustion; Waste Oil Combustion: Stationary Gas Turbines for Electricity Generation; Heavy-duty Natural Gas-fired Pipeline Compressor Engines; Large Stationary Diesel and all Stationary Dual-fuel engines; Natural Gas Processing; Organic Liquid Storage Tanks; Meat Smokehouses; Meat Rendering Plants; Canned Fruits and Vegetables; Dehydrated Fruits and Vegetables; Pickles, Sauces and Salad Dressing; Grain Elevators and Processes; Cereal Breakfast Foods; Pasta Manufacturing; Vegetable Oil Processing; Wines and Brandy; Coffee Roasting; Charcoal; Coal Cleaning; Frit Manufacturing; Sandmore » and Gravel Processing; Diatomite Processing; Talc Processing; Vermiculite Processing; paved Roads; and Unpaved Roads. Also included is information on Generalized Particle Size Distributions.« less

  14. 23 CFR 646.214 - Design.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS RAILROADS Railroad-Highway... crossing improvements. (1) All traffic control devices proposed shall comply with the latest edition of the Manual on Uniform Traffic Control Devices for Streets and Highways supplemented to the extent applicable...

  15. 40 CFR 141.21 - Coliform sampling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... water) with the intent that if the method they choose has an unacceptable false-positive or negative...), supplemented with 100 µg/mL of MUG. If the 18th edition is used, incubate the agar plate at 35 °C for 4 hours...

  16. 40 CFR 141.21 - Coliform sampling.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... water) with the intent that if the method they choose has an unacceptable false-positive or negative...), supplemented with 100 µg/mL of MUG. If the 18th edition is used, incubate the agar plate at 35 °C for 4 hours...

  17. 40 CFR 141.21 - Coliform sampling.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... water) with the intent that if the method they choose has an unacceptable false-positive or negative...), supplemented with 100 µg/mL of MUG. If the 18th edition is used, incubate the agar plate at 35 °C for 4 hours...

  18. Molecular biology at the cutting edge: A review on CRISPR/CAS9 gene editing for undergraduates.

    PubMed

    Thurtle-Schmidt, Deborah M; Lo, Te-Wen

    2018-03-01

    Disrupting a gene to determine its effect on an organism's phenotype is an indispensable tool in molecular biology. Such techniques are critical for understanding how a gene product contributes to the development and cellular identity of organisms. The explosion of genomic sequencing technologies combined with recent advances in genome-editing techniques has elevated the possibilities of genetic manipulations in numerous organisms in which these experiments were previously not readily accessible or possible. Introducing the next generation of molecular biologists to these emerging techniques is key in the modern biology classroom. This comprehensive review introduces undergraduates to CRISPR/Cas9 editing and its uses in genetic studies. The goals of this review are to explain how CRISPR functions as a prokaryotic immune system, describe how researchers generate mutations with CRISPR/Cas9, highlight how Cas9 has been adapted for new functions, and discuss ethical considerations of genome editing. Additionally, anticipatory guides and questions for discussion are posed throughout the review to encourage active exploration of these topics in the classroom. Finally, the supplement includes a study guide and practical suggestions to incorporate CRISPR/Cas9 experiments into lab courses at the undergraduate level. © 2018 The Authors Biochemistry and Molecular Biology Education published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 46(2):195-205, 2018. © 2018 The Authors Biochemistry and Molecular Biology Education published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.

  19. Combining pain therapy with lifestyle: the role of personalized nutrition and nutritional supplements according to the SIMPAR Feed Your Destiny approach

    PubMed Central

    De Gregori, Manuela; Muscoli, Carolina; Schatman, Michael E; Stallone, Tiziana; Intelligente, Fabio; Rondanelli, Mariangela; Franceschi, Francesco; Arranz, Laura Isabel; Lorente-Cebrián, Silvia; Salamone, Maurizio; Ilari, Sara; Belfer, Inna; Allegri, Massimo

    2016-01-01

    Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, omega-3 fatty acids, and curcumin supplementation as key elements in modulating the efficacy of analgesic treatments, including opioids. These main topics were addressed during the first edition of the Study In Multidisciplinary Pain Research workshop: “FYD (Feed Your Destiny): Fighting Pain”, held on April 7, 2016, in Rome, Italy, which was sponsored by a grant from the Italian Ministry of Instruction on “Nutraceuticals and Innovative Pharmacology”. The take-home message of this workshop was the recognition that patients with chronic pain should undergo nutritional assessment and counseling, which should be initiated at the onset of treatment. Some foods and supplements used in personalized treatment will likely improve clinical outcomes of analgesic therapy and result in considerable improvement of patient compliance and quality of life. From our current perspective, the potential benefit of including nutrition in personalizing pain medicine is formidable and highly promising. PMID:27994480

  20. USEPA MANUAL OF METHODS FOR VIROLOGY

    EPA Science Inventory

    This chapter describes procedures for the detection of coliphases in water matrices. These procedures are based on those presented in the Supplement to the 20th Edition of Standard Methods for the Examination of Water and Eastewater and EPA Methods 1601 and 1602. Two quantitati...

  1. Classification in Australia.

    ERIC Educational Resources Information Center

    McKinlay, John

    Despite some inroads by the Library of Congress Classification and short-lived experimentation with Universal Decimal Classification and Bliss Classification, Dewey Decimal Classification, with its ability in recent editions to be hospitable to local needs, remains the most widely used classification system in Australia. Although supplemented at…

  2. Factors associated with compliance of prenatal iron folate supplementation among women in Mecha district, Western Amhara: a cross-sectional study

    PubMed Central

    Taye, Bekele; Abeje, Gedefaw; Mekonen, Alemetsehaye

    2015-01-01

    Introduction Iron and folate supplementation can effectively control and prevent anaemia in pregnancy. In Ethiopia, all pregnant women are prescribed iron folate during their ANC visit. However, limited adherence is thought to be a major reason for the low effectiveness of iron supplementation programs. Therefore this study was done to investigate factors associated with compliance of prenatal iron folate supplementation among women who gave birth in the last 12 months before the survey in Mecha district. Methods Community based cross sectional study design was employed in Mecha district from June 25 - July 15/2013. A sample of 634 women who gave birth 12 months before the survey was included in the study. Study participants were selected by systematic random sampling technique after allocating the total sample to each kebele proportionally. Data were collected using a pre-tested structured Amharic questionnaire. Collected data were edited, coded and entered to Epi info version 3.1 and exported to‘ SPSS version 16. Bivariate and multivariable analysis was computed. Results A total of 628 women who gave birth twelve months before the survey were enrolled. In this study only 20.4% of participants were compliant with iron foliate supplementation. In multivariable analysis, age of the mother, educational status of the mother, knowledge of anaemia and iron folate tablets, and history of anaemia during pregnancy were significantly associated with compliance to iron folate supplementation (P < .05). Belief that too many tablets would harm the baby and fear of side effects were the major reasons given for noncompliance. Conclusion Compliance to iron folate supplementation is very low in the study area. Increasing female education and increasing knowledge of women about anaemia and iron folate tablets are recommended to increase compliance to iron folate supplementation. PMID:26090001

  3. Factors associated with compliance of prenatal iron folate supplementation among women in Mecha district, Western Amhara: a cross-sectional study.

    PubMed

    Taye, Bekele; Abeje, Gedefaw; Mekonen, Alemetsehaye

    2015-01-01

    Iron and folate supplementation can effectively control and prevent anaemia in pregnancy. In Ethiopia, all pregnant women are prescribed iron folate during their ANC visit. However, limited adherence is thought to be a major reason for the low effectiveness of iron supplementation programs. Therefore this study was done to investigate factors associated with compliance of prenatal iron folate supplementation among women who gave birth in the last 12 months before the survey in Mecha district. Community based cross sectional study design was employed in Mecha district from June 25 - July 15/2013. A sample of 634 women who gave birth 12 months before the survey was included in the study. Study participants were selected by systematic random sampling technique after allocating the total sample to each kebele proportionally. Data were collected using a pre-tested structured Amharic questionnaire. Collected data were edited, coded and entered to Epi info version 3.1 and exported to' SPSS version 16. Bivariate and multivariable analysis was computed. A total of 628 women who gave birth twelve months before the survey were enrolled. In this study only 20.4% of participants were compliant with iron foliate supplementation. In multivariable analysis, age of the mother, educational status of the mother, knowledge of anaemia and iron folate tablets, and history of anaemia during pregnancy were significantly associated with compliance to iron folate supplementation (P<.05). Belief that too many tablets would harm the baby and fear of side effects were the major reasons given for noncompliance. Compliance to iron folate supplementation is very low in the study area. Increasing female education and increasing knowledge of women about anaemia and iron folate tablets are recommended to increase compliance to iron folate supplementation.

  4. Prenatal Micronutrient Supplementation Is Not Associated with Intellectual Development of Young School-Aged Children.

    PubMed

    Li, Chao; Zeng, Lingxia; Wang, Duolao; Yang, Wenfang; Dang, Shaonong; Zhou, Jing; Yan, Hong

    2015-08-01

    Micronutrient supplementation is often prescribed during pregnancy. The effects of prenatal iron and multimicronutrient supplementation on intellectual development in young school-aged children are less than clear. The aim of this study was to examine the long-term effects of prenatal iron plus folic acid or multiple micronutrient (including iron and folic acid) supplementation vs. folic acid supplementation on the intellectual development of young school-aged children in rural China. Young school-aged children (aged 7-10 y, n = 1744) of women who had participated in a trial of prenatal supplementation with various combinations of micronutrients and remained residents in 2 rural counties in China were followed. We measured their intellectual development by Wechsler Intelligence Scale for Children Fourth Edition (WISC-IV). The WISC-IV generated the Full-Scale Intelligence Quotient (FSIQ), Verbal Comprehension Index (VCI), Working Memory Index (WMI), Perceptual Reasoning Index (PRI), and Processing Speed Index (PSI). Multilevel analyses were used to assess the effect of prenatal micronutrient supplementation on the intellectual development of children. The mean differences in FSIQ, VCI, WMI, PRI, and PSI, respectively, were not significant between prenatal folic acid supplementation and either iron plus folic acid [-0.34 (P = 0.65), -0.06 (P = 0.95), -0.22 (P = 0.76), -0.01 (P = 0.99), and -1.26 (P = 0.11)] or multimicronutrient [-0.39 (P = 0.60), -0.64 (P = 0.48), 0.11 (P = 0.87), -0.43 (P = 0.59), and -0.34; (P = 0.65)] supplementation after adjusting for confounders. There is no evidence to suggest a different effect on intellectual development between prenatal iron plus folic acid, multimicronutrient supplementation, and prenatal folic acid supplementation in children aged 7-10 y. This trial was registered at www.isrctn.com as ISRCTN08850194. © 2015 American Society for Nutrition.

  5. 10 CFR 435.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Definitions. 435.2 Section 435.2 Energy DEPARTMENT OF... Mandatory Energy Efficiency Standards for Federal Low-Rise Residential Buildings. § 435.2 Definitions. For... International Energy Conservation Code, 2004 Supplement Edition, January 2005 (incorporated by reference, see...

  6. 77 FR 28805 - Energy Conservation Program: Test Procedures for Microwave Ovens

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ...On November 23, 2011, the U.S. Department of Energy (DOE) issued a supplemental notice of proposed rulemaking (SNOPR) to amend the test procedures for microwave ovens. That SNOPR proposed amendments to the DOE test procedure to incorporate provisions from the International Electrotechnical Commission (IEC) Standard 62301, ``Household electrical appliances--Measurement of standby power,'' Edition 2.0 2011-01 (IEC Standard 62301 (Second Edition)). Today's SNOPR proposes additional provisions for measuring the standby mode and off mode energy use of products that combine a microwave oven with other appliance functionality, as well as minor technical clarifications.

  7. Daily Report, Supplement, East Europe

    DTIC Science & Technology

    1993-08-02

    34Milosevic’s Letica in the Federal Executive Building"] [Text] The assault on all the Serbian lands and the ongoing restructuring of personnel...were publishing there), and he received the Vuk Karadzic Prize for his editing of that journal, even.... Milosevic’s Letica , however, also had

  8. 21 CFR 701.3 - Designation of ingredients.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....) Cosmetic Ingredient Dictionary, Second Ed., 1977 (available from the Cosmetic, Toiletry and Fragrance... revised monographs are published in supplements to this dictionary edition by July 18, 1980. Acid Black 2.../federal_register/code_of_federal_regulations/ibr_locations.html. (v) USAN and the USP dictionary of drug...

  9. Discovering Historic Iowa. American Revolution Bicentennial Edition.

    ERIC Educational Resources Information Center

    Pratt, LeRoy G.

    Prepared in recognition of the Bicentennial, this historic guide of Iowa is intended to supplement materials prepared by the Iowa Curriculum Division. It provides, in one convenient reference, information for use by teachers, students, tourists, and others interested in Iowa's history. Up-to-date information is given on historical societies,…

  10. LAS Language Arts Supplement, English. Revised Edition.

    ERIC Educational Resources Information Center

    DeAvila, Edward A.; Duncan, Sharon E.

    This collection of over 100 games and activities is intended to increase oral proficiency among Spanish-speaking children without requiring reading skills. The collection grew out of the desire to provide remedies for specific linguistic weaknesses in English as identified by the Language Assessment Scales (LAS). Because tongue twisters, riddles…

  11. Video Feedforward for Reading

    ERIC Educational Resources Information Center

    Dowrick, Peter W.; Kim-Rupnow, Weol Soon; Power, Thomas J.

    2006-01-01

    Video feedforward can create images of positive futures, as has been shown by researchers using self-modeling methods to teach new skills with carefully planned and edited videos that show the future capability of the individual. As a supplement to tutoring provided by community members, we extended these practices to young children struggling to…

  12. Criminal Justice in America. Second Edition.

    ERIC Educational Resources Information Center

    Croddy, Marshall; And Others

    This comprehensive textbook on criminal justice is intended to serve as the foundation for a high school course on law-related education or as a supplement for civics, government or contemporary-issues courses. Designed to foster critical thinking and analytical skills, the book provides students with an understanding of the criminal justice…

  13. Introduction to World Peace through World Law. Revised Edition.

    ERIC Educational Resources Information Center

    Clark, Grenville; Sohn, Louis

    Two models for changing existing international organizations into effective instruments of world governance are presented. The first model revises the present Charter of the United Nations; the second calls for a new world security and development organization which would supplement the existing machinery of the United Nations for peacekeeping,…

  14. Indians of Washington State. Revised Edition.

    ERIC Educational Resources Information Center

    Milhafer, Judith; And Others

    This unit supplements social studies curriculum in Washington state schools and is offered to help teachers design courses on Indians of the Pacific Northwest. The unit is designed to build understanding and appreciation for historical and contemporary Indian culture, and to examine how people meet their needs using natural resources and…

  15. Farm Business Records and Financial Statements. Teacher Edition. Farm Business Management Series.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    Contained in this teacher's guide are the materials necessary to teach seven instructional units related to keeping farm business records and preparing financial statements. The following instructional units are presented: (1) orientation; (2) inventories; (3) journal entry; (4) enterprise accounting and supplemental records; (5) cash flow…

  16. WAIS-IV Subtest Covariance Structure: Conceptual and Statistical Considerations

    ERIC Educational Resources Information Center

    Ward, L. Charles; Bergman, Maria A.; Hebert, Katina R.

    2012-01-01

    D. Wechsler (2008b) reported confirmatory factor analyses (CFAs) with standardization data (ages 16-69 years) for 10 core and 5 supplemental subtests from the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). Analyses of the 15 subtests supported 4 hypothesized oblique factors (Verbal Comprehension, Working Memory, Perceptual Reasoning,…

  17. Criminal Justice in America. Teacher's Guide. Second Edition.

    ERIC Educational Resources Information Center

    Croddy, Marshall; Hayes, Bill

    This teacher's guide outlines effective strategies for using "Criminal Justice in America." This comprehensive textbook on criminal justice may serve either as the foundation for a high school law-related education course or as a supplemental text for civics, government or contemporary-issues courses. Designed to foster critical thinking…

  18. Directrices de los Servicios de Salud para Estudiantes Migratorios (Guidelines for Health Services for Migrant Students).

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Bureau of Community Services and Migrant Education.

    To promote uniformity and continuity, standards have been established for planning, implementing, and evaluating student health programs provided by grade K-12 migrant education programs throughout California. In this Spanish language edition, state-mandated health requirements, the rationale for supplemental services, methods of providing…

  19. LAS Language Arts Supplement, Spanish. Revised Edition.

    ERIC Educational Resources Information Center

    DeAvila, Edward A.; Duncan, Sharon E.

    Like its English counterpart, this is a collection of over 100 games and activities whose intent is to increase oral proficiency without requiring reading skills. The collection grew out of the desire to provide remedies for specific linguistic weaknesses in Spanish as identified by the Language Assessment Scales. Because tongue twisters, riddles,…

  20. Native Americans of Washington State (A Curriculum Guide for Elementary Grades). First Edition.

    ERIC Educational Resources Information Center

    Forsyth, Karen Williams; Neal, Colleen

    Developed as a supplemental curriculum guide for elementary teachers, the guide assists in implementing Native American activities to classroom curriculum to make students aware of the numerous tribes within the state of Washington. Divided in three geographic, cultural areas (Northwest Coast region, Puget Sound Lowlands region, and Plateau…

  1. Workability of Mass Concrete. Report 2. Supplemental Proportioning Parameters.

    DTIC Science & Technology

    1996-09-01

    Information given in the report shall not be used in advertising or sales promotion to indicate endorsement of this product by U.S. Government. 14 Chapter 2... SALES PROMOTION TO INDICATE EITHER EXPLICITLY OR IMPLICITLY ENDORSEMENT OF THIS PRODUCT BY THE U.S. GOVERNMENT. FORM EDITION OF 1 SEP 84 IS OBSOLETE

  2. 15 CFR Supplement No. 1 to Part 760 - Interpretations

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... in a boycotted country; (ii) With any business concern organized under the laws of a boycotted... this interpretation pursuant to the Export Administration Amendments Act of 1979 (Public Law 95-52) and..., 1978 (43 FR 3508) and contained in the 15 CFR edition revised as of January 1, 1979. I. Certifications...

  3. Clustered Regularly Interspaced Short Palindromic Repeats: Challenges in Treating Retinal Disease.

    PubMed

    Chrenek, Micah A; Nickerson, John M; Boatright, Jeffrey H

    2016-01-01

    Ophthalmic researchers and clinicians arguably have led the way for safe, effective gene therapy, most notably with adeno-associated viral gene supplementation in the treatment for patients with Leber congenital amaurosis type 2 with mutations in the RPE65 gene. These successes notwithstanding, most other genetic retinal disease will be refractory to supplementation. The ideal gene therapy approach would correct gene mutations to restore normal function in the affected cells. Gene editing in which a mutant allele is inactivated or converted to sequence that restores normal function is hypothetically one such approach. Such editing involves site-specific digestion of mutant genomic DNA followed by repair. Previous experimental approaches were hampered by inaccurate and high rates of off-site lesioning and by overall low digestion rates. A new tool, clustered regularly interspaced short palindromic repeats coupled with the nuclease Cas9, may address both shortcomings. Some of the many challenges that must be addressed in moving clustered regularly interspaced short palindromic repeats coupled with the nuclease Cas9 therapies to the ophthalmic clinic are discussed here.

  4. Supplemental Journal Article Materials: A progress report on an information industry initiative

    NASA Astrophysics Data System (ADS)

    Schwarzman, A. B.

    2011-12-01

    Who could possibly quibble with the idea of publishing supplemental materials to a journal article? Making them available makes it possible for the Earth and space scientists to demonstrate supporting evidence, such as multimedia, computer programs, and datasets; gives the authors the opportunity to present in-depth studies that would not otherwise be available; and enables the readers to replicate experiments and verify their results. However, the scholarly publishing ecosystem is now being threatened by a veritable tsunami of supplemental materials that have to be peer reviewed, identified, described, and made discoverable and citeable; such materials also have to be archived, preserved, and perpetually converted to the contemporary formats to be available to a future researcher. Moreover, the readers often have no clear indication of how critical a particular supplemental material is to the scientific conclusions of the article and thus are not sure whether they should spend their time reading/viewing/running it. In some cases it is not even clear what the material actually supplements. While one segment of the research community argues that even more supplemental materials should be made available, another segment increasingly voices its concern stating categorically that a research article is not a data dump or an FTP site. From the publisher's perspective, dealing with supplemental materials in a responsible fashion is becoming an increasingly costly proposition. Faced with formidable challenges of managing supplemental materials, the information profession community in 2010 formed a joint NISO/NFAIS Working Group to develop Recommended Practices for curating supplemental materials during their life cycle, including but not limited to their selection, peer review, editing, production, presentation, providing context, identification, linking, citing, hosting, discovery, metadata and markup, packaging, accessibility, and preservation. The Recommended Practices also intend to address roles and responsibilities of authors, editors, peer reviewers, publishers, libraries, abstracting and indexing services, and official data centers and institutional repositories. Finally, the document is going to contain broad principles and detailed technical implementation related to metadata, linking, packaging, and accessibility of supplemental materials. In this presentation, a co-chair of the NISO/NFAIS Working Group will report on the Group's latest progress in developing the Recommended Practices for Supplemental Journal Article Materials.

  5. Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial

    PubMed Central

    Gould, Jacqueline F; Treyvaud, Karli; Yelland, Lisa N; Anderson, Peter J; Smithers, Lisa G; Gibson, Robert A; McPhee, Andrew J; Makrides, Maria

    2016-01-01

    Introduction Despite recommendations that pregnant women increase their docosahexaenoic acid (DHA) intake to support fetal brain development, a recent systematic review found a lack of high-quality data to support the long-term effects of DHA supplementation on children's neurodevelopment. Methods and analysis We will assess child neurodevelopment at 7 years of age in follow-up of a multicentre double-blind randomised controlled trial of DHA supplementation in pregnancy. In 2010–2012, n=2399 Australian women with a singleton pregnancy <21 weeks’ gestation were randomised to receive 3 capsules daily containing a total dose of 800 mg DHA/day or a vegetable oil placebo until birth. N=726 children from Adelaide (all n=97 born preterm, random sample of n=630 born at term) were selected for neurodevelopmental follow-up and n=638 (preterm n=85) are still enrolled at 7 years of age. At the 7-year follow-up, a psychologist will assess the primary outcome, IQ, with the Wechsler Abbreviated Scale of Intelligence, Second Edition. Specific measures of executive functioning (Fruit Stroop and the Rey Complex Figure), attention (Test of Everyday Attention for Children), memory and learning (Rey Auditory Verbal Learning Test), language (Clinical Evaluation of Language Fundamentals, Fourth Edition) and basic educational skills (Wide Range Achievement Test, Fourth Edition) will also be administered. Caregivers will be asked to complete questionnaires measuring behaviour and executive functioning. Families, clinicians and research personnel are blinded to group assignment with the exception of families who requested unblinding prior to the follow-up. All analyses will be conducted according to the intention-to-treat principal. Ethics and dissemination All procedures will be approved by the relevant institutional ethics committees prior to start of the study. The results of this study will be disseminated in peer-reviewed journal publications and academic presentations. Trial registration numbers ACTRN12605000569606 and ACTRN12614000770662. PMID:27188814

  6. 2016 Oncology Nursing Society Annual Congress: Podium, E-Poster, and Poster Session Abstracts.

    PubMed

    2016-03-01

    Abstracts appear as they were submitted and have not undergone editing or the Oncology Nursing Forum's review process. Only abstracts that will be presented appear online. Poster numbers are subject to change. For updated poster numbers, visit congress.ons.org or check the Congress guide. Data published in abstracts presented at ONS's Annual Congress are embargoed until the conclusion of the presentation. Coverage and/or distribution of an abstract, poster, or any of its supplemental material to or by the news media, any commercial entity, or individuals, including the authors of said abstract, is strictly prohibited until the embargo is lifted. Promotion of general topics and speakers is encouraged within these guidelines.

  7. [History of Japanese Committee for Anatomical Nomenclature].

    PubMed

    Kimura, Kunihiko

    2008-12-01

    This paper records a history of the Japanese Committee of Anatomical Nomenclature since 1990, as a supplement to the previous report (1991), explains a progressing of the edition of Japanese medical terms by the Japanese Association of Medical Sciences and the Ministry of Education, Sciences and Culture, and points out of some problems on terms in Japanese.

  8. Jelly Jam, the People Preserver. Teaching Guide. An Environmental Manual for Teachers and Parents. Revised Edition.

    ERIC Educational Resources Information Center

    Friedman, Judi

    Designed for teachers of students in grades 2 through 4, this teaching guide for a self-teaching, interdisciplinary reading and activity program comprises a complete supplemental reading, science, and social studies approach to the problems of environmental pollution. Jelly Jam, a caring little animal, helps children understand how air, water, and…

  9. Advanced Beef Unit for Advanced Livestock Production Curriculum. Selected Readings. AGDEX 420/00.

    ERIC Educational Resources Information Center

    Sparks, Jim; Stewart, Bob R.

    These selected readings are designed to supplement James Gillespie's "Modern Livestock and Poultry Production" (2nd edition) as the student reference for the advanced beef unit. The 15 lessons build on Agricultural Science I and II competencies. Topics of the 15 lessons are: importance of the beef enterprise; cost of beef production;…

  10. Classroom Techniques: Foreign Languages and English as Second Language.

    ERIC Educational Resources Information Center

    Allen, Edward David; Valette, Rebecca M.

    The aim of the handbook, which is a revised and expanded edition of "Modern Language Classroom Techniques" (1972), is to show the teacher ways of implementing and supplementing existing materials. The suggested teaching procedures may be used with classes of varying sizes and levels, and with any method. Part One of this handbook presents an…

  11. Safety on the Job. Some Guidelines for Working Safely. Instructor's Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This teacher's guide was developed to help teachers (especially in Oklahoma) promote safe practices on the job. As a supplement to existing programs in the requirements for job safety, this book can also promote same basic safety attitudes and help support basic safety concepts, with an emphasis on accident prevention. The guide contains eight…

  12. Movement in Steady Beat: Learning on the Move, Ages 3-7. Second Edition.

    ERIC Educational Resources Information Center

    Weikart, Phyllis S.

    The ability to feel and maintain steady, rhythmic beat is important for children to develop in early childhood and will assist them in mastering concepts in language and literacy, mathematics, and other content areas as well as increase body coordination and related physical abilities. Designed as an activity supplement to High Scope movement and…

  13. The Internet Resource Directory for K-12 Teachers and Librarians. 97/98 Edition.

    ERIC Educational Resources Information Center

    Miller, Elizabeth B.

    This directory is the fourth in an annual series of Internet guides for educators, librarians, and school administrators, and provides tips on access to, as well as addresses for, online resources that support and enrich the K-12 curriculum and supplement the school library core collection. Sites that help educators develop professionally are also…

  14. Other Lands, Other Peoples; A Country-by-Country Fact Book.

    ERIC Educational Resources Information Center

    Greenberg, Nancy M., Ed.

    This fifth edition has been designed for use by teachers and students as a supplement to regular textbooks as well as for the original purpose of providing vital information for foreign visitors. The 141 independent or quasi-independent nations of Europe, the Middle East, Asia and the South Pacific, Africa, Latin America, and Canada are described.…

  15. Effects of Drugs on Body Systems [1970 Edition].

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Designed for use in biology classes at the senior high school level, this informational booklet can serve as a resource in an interdisciplinary drug abuse education program. Its purpose is to assist the teacher who wishes to supplement the regular program with instruction in the effects of drugs on body systems by providing materials to be used at…

  16. 15 CFR Supplement No. 3 to Part 760 - Interpretation

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Article 2, Annex II of the Peace Treaty between Egypt and Israel, Egypt's participation in the Arab economic boycott of Israel was formally terminated on January 25, 1980. On the basis of this action, it is... force against Israel (see 43 FR 16969, April 21, 1978 or the 15 CFR edition revised as of January 1...

  17. Failure Atlas for Rolling Bearings in Wind Turbines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tallian, T. E.

    2006-01-01

    This Atlas is structured as a supplement to the book: T.E. Tallian: Failure Atlas for Hertz Contact Machine Elements, 2nd edition, ASME Press New York, (1999). The content of the atlas comprises plate pages from the book that contain bearing failure images, application data, and descriptions of failure mode, image, and suspected failure causes. Rolling bearings are a critical component of the mainshaft system, gearbox and generator in the rapidly developing technology of power generating wind turbines. The demands for long service life are stringent; the design load, speed and temperature regimes are demanding and the environmental conditions including weather,more » contamination, impediments to monitoring and maintenance are often unfavorable. As a result, experience has shown that the rolling bearings are prone to a variety of failure modes that may prevent achievement of design lives. Morphological failure diagnosis is extensively used in the failure analysis and improvement of bearing operation. Accumulated experience shows that the failure appearance and mode of failure causation in wind turbine bearings has many distinguishing features. The present Atlas is a first effort to collect an interpreted database of specifically wind turbine related rolling bearing failures and make it widely available. This Atlas is structured as a supplement to the book: T. E. Tallian: Failure Atlas for Hertz Contact Machine Elements, 2d edition, ASME Press New York, (1999). The main body of that book is a comprehensive collection of self-contained pages called Plates, containing failure images, bearing and application data, and three descriptions: failure mode, image and suspected failure causes. The Plates are sorted by main failure mode into chapters. Each chapter is preceded by a general technical discussion of the failure mode, its appearance and causes. The Plates part is supplemented by an introductory part, describing the appearance classification and failure classification systems used, and by several indexes. The present Atlas is intended as a supplement to the book. It has the same structure but contains only Plate pages, arranged in chapters, each with a chapter heading page giving a short definition of the failure mode illustrated. Each Plate page is self contained, with images, bearing and application data, and descriptions of the failure mode, the images and the suspected causes. Images are provided in two resolutions: The text page includes 6 by 9 cm images. In addition, high resolution image files are attached, to be retrieved by clicking on their 'push pin' icon. While the material in the present Atlas is self-contained, it is nonetheless a supplement to the book and the complete interpretation of the terse image descriptions and of the system underlying the failure code presupposes familiarity with the book. Since this Atlas is a supplement to the book, its chapter numbering follows that of the book. Not all failure modes covered in the book have been found among the observed wind turbines. For that reason, and because of the omission of introductory matter, the chapter numbers in this Atlas are not a continuous sequence.« less

  18. Gene editing tools: state-of-the-art and the road ahead for the model and non-model fishes.

    PubMed

    Barman, Hirak Kumar; Rasal, Kiran Dashrath; Chakrapani, Vemulawada; Ninawe, A S; Vengayil, Doyil T; Asrafuzzaman, Syed; Sundaray, Jitendra K; Jayasankar, Pallipuram

    2017-10-01

    Advancements in the DNA sequencing technologies and computational biology have revolutionized genome/transcriptome sequencing of non-model fishes at an affordable cost. This has led to a paradigm shift with regard to our heightened understandings of structure-functional relationships of genes at a global level, from model animals/fishes to non-model large animals/fishes. Whole genome/transcriptome sequencing technologies were supplemented with the series of discoveries in gene editing tools, which are being used to modify genes at pre-determined positions using programmable nucleases to explore their respective in vivo functions. For a long time, targeted gene disruption experiments were mostly restricted to embryonic stem cells, advances in gene editing technologies such as zinc finger nuclease, transcriptional activator-like effector nucleases and CRISPR (clustered regulatory interspaced short palindromic repeats)/CRISPR-associated nucleases have facilitated targeted genetic modifications beyond stem cells to a wide range of somatic cell lines across species from laboratory animals to farmed animals/fishes. In this review, we discuss use of different gene editing tools and the strategic implications in fish species for basic and applied biology research.

  19. The Internet Resource Directory for K-12 Teachers and Librarians, 95/96 Edition.

    ERIC Educational Resources Information Center

    Miller, Elizabeth B.

    This directory is the second in an annual series of Internet guides for educators and librarians, and provides tips on access to, as well as addresses for, online resources that support the K-12 curriculum and supplement school library core collections. The listings in the catalog are limited to free and frequently updated resources; over 300 new…

  20. Education Policy and Practice "under" New Labour: An Epistolary Critique

    ERIC Educational Resources Information Center

    Richards, Colin

    2010-01-01

    Since the election of 1997 New Labour's education policy has been subject to variety of forms of critique--in this journal and others. One of the sources for such critique has been a barrage of letters unleashed for over a decade by Colin Richards in the "Times Educational Supplement". Here are reproduced a self-edited selection of his…

  1. State of Metropolitan America: On the Front Lines of Demographic Transformation

    ERIC Educational Resources Information Center

    Brookings Institution, 2010

    2010-01-01

    This report marks the inaugural edition of a regular summary report in Brookings' "State of Metropolitan America" series. It focuses on the major demographic forces transforming the nation and large metropolitan areas in the 2000s. In this sense, it previews what people will learn from the results of the 2010 census, as well as supplements those…

  2. Black Chronicle: An American History Textbook Supplement. Third Edition. Bulletin No. 91546.

    ERIC Educational Resources Information Center

    Kailin, Clarence S.

    This book, a revision and updating of a work first published under the same title in 1974, presents a detailed chronological history of African Americans in the United States. The description begins with the origins of Homo sapiens in Africa, and traces the African American story from slavery in North America through the U.S. Civil War, the…

  3. Children's Books to Enrich the Social Studies: For the Elementary Grades. Revised Edition.

    ERIC Educational Resources Information Center

    Huus, Helen

    Six hundred and thirty social studies books for elementary children, published between 1935 and 1964, are listed in this revised annotated bibliography intended for teachers and librarians. The aim of the book is to provide, as a supplement to the classroom texts, a list of fact and fiction illustrating different ways of life in other countries in…

  4. Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    PubMed Central

    Manji, Karim P.; McDonald, Christine M.; Kupka, Roland; Bosch, Ronald J.; Kisenge, Rodrick; Aboud, Said; Bellinger, David C.; Fawzi, Wafaie W.

    2014-01-01

    Background: Micronutrient deficiencies and in utero exposure to HIV may impair infant neurodevelopment. Objective: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants. Methods: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months. Results: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = −0.01, 0.78, p = 0.06). Conclusion: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months. PMID:24567309

  5. 2018 Congress Poster Abstracts

    PubMed

    2018-02-21

    Each abstract has been indexed according to the first author. Abstracts appear as they were submitted and have not undergone editing or the Oncology Nursing Forum’s review process. Only abstracts that will be presented appear here. Poster numbers are subject to change. For updated poster numbers, visit congress.ons.org or check the Congress guide. Data published in abstracts presented at the ONS 43rd Annual Congress are embargoed until the conclusion of the presentation. Coverage and/or distribution of an abstract, poster, or any of its supplemental material to or by the news media, any commercial entity, or individuals, including the authors of said abstract, is strictly prohibited until the embargo is lifted. Promotion of general topics and speakers is encouraged within these guidelines.

  6. Predicting children with pervasive developmental disorders using the Wechsler Intelligence Scale for Children-Third Edition.

    PubMed

    Koyama, Tomonori; Inada, Naoko; Tsujii, Hiromi; Kurita, Hiroshi

    2008-08-01

    An original combination score (i.e. the sum of Vocabulary and Comprehension subtracted from the sum of Block Design and Digit Span) was created from the four Wechsler Intelligence Scale for Children-Third Edition (WISC-III) subtests identified by discriminant analysis on WISC-III data from 139/129 children with/without pervasive developmental disorders (PDD; mean, 8.3/8.1 years) and its utility examined for predicting PDD. Its best cut-off was 2/3, with sensitivity, specificity, positive and negative predictive values of 0.68, 0.61, 0.65 and 0.64, respectively. The score seems useful, so long as clinicians are aware of its limitations and use it only as a supplemental measure in PDD diagnosis.

  7. Speed breeding is a powerful tool to accelerate crop research and breeding.

    PubMed

    Watson, Amy; Ghosh, Sreya; Williams, Matthew J; Cuddy, William S; Simmonds, James; Rey, María-Dolores; Asyraf Md Hatta, M; Hinchliffe, Alison; Steed, Andrew; Reynolds, Daniel; Adamski, Nikolai M; Breakspear, Andy; Korolev, Andrey; Rayner, Tracey; Dixon, Laura E; Riaz, Adnan; Martin, William; Ryan, Merrill; Edwards, David; Batley, Jacqueline; Raman, Harsh; Carter, Jeremy; Rogers, Christian; Domoney, Claire; Moore, Graham; Harwood, Wendy; Nicholson, Paul; Dieters, Mark J; DeLacy, Ian H; Zhou, Ji; Uauy, Cristobal; Boden, Scott A; Park, Robert F; Wulff, Brande B H; Hickey, Lee T

    2018-01-01

    The growing human population and a changing environment have raised significant concern for global food security, with the current improvement rate of several important crops inadequate to meet future demand 1 . This slow improvement rate is attributed partly to the long generation times of crop plants. Here, we present a method called 'speed breeding', which greatly shortens generation time and accelerates breeding and research programmes. Speed breeding can be used to achieve up to 6 generations per year for spring wheat (Triticum aestivum), durum wheat (T. durum), barley (Hordeum vulgare), chickpea (Cicer arietinum) and pea (Pisum sativum), and 4 generations for canola (Brassica napus), instead of 2-3 under normal glasshouse conditions. We demonstrate that speed breeding in fully enclosed, controlled-environment growth chambers can accelerate plant development for research purposes, including phenotyping of adult plant traits, mutant studies and transformation. The use of supplemental lighting in a glasshouse environment allows rapid generation cycling through single seed descent (SSD) and potential for adaptation to larger-scale crop improvement programs. Cost saving through light-emitting diode (LED) supplemental lighting is also outlined. We envisage great potential for integrating speed breeding with other modern crop breeding technologies, including high-throughput genotyping, genome editing and genomic selection, accelerating the rate of crop improvement.

  8. Residential Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook.

    ERIC Educational Resources Information Center

    Taylor, Mark

    Residential Wiring, the second publication in a series of three wiring publications, prepares students for entry-level employment in the residential wiring trade. Instructional materials include a teacher edition, student guide, and student workbook. The teacher edition begins with introductory pages, including a training and competency profile,…

  9. AQME: A forensic mitochondrial DNA analysis tool for next-generation sequencing data.

    PubMed

    Sturk-Andreaggi, Kimberly; Peck, Michelle A; Boysen, Cecilie; Dekker, Patrick; McMahon, Timothy P; Marshall, Charla K

    2017-11-01

    The feasibility of generating mitochondrial DNA (mtDNA) data has expanded considerably with the advent of next-generation sequencing (NGS), specifically in the generation of entire mtDNA genome (mitogenome) sequences. However, the analysis of these data has emerged as the greatest challenge to implementation in forensics. To address this need, a custom toolkit for use in the CLC Genomics Workbench (QIAGEN, Hilden, Germany) was developed through a collaborative effort between the Armed Forces Medical Examiner System - Armed Forces DNA Identification Laboratory (AFMES-AFDIL) and QIAGEN Bioinformatics. The AFDIL-QIAGEN mtDNA Expert, or AQME, generates an editable mtDNA profile that employs forensic conventions and includes the interpretation range required for mtDNA data reporting. AQME also integrates an mtDNA haplogroup estimate into the analysis workflow, which provides the analyst with phylogenetic nomenclature guidance and a profile quality check without the use of an external tool. Supplemental AQME outputs such as nucleotide-per-position metrics, configurable export files, and an audit trail are produced to assist the analyst during review. AQME is applied to standard CLC outputs and thus can be incorporated into any mtDNA bioinformatics pipeline within CLC regardless of sample type, library preparation or NGS platform. An evaluation of AQME was performed to demonstrate its functionality and reliability for the analysis of mitogenome NGS data. The study analyzed Illumina mitogenome data from 21 samples (including associated controls) of varying quality and sample preparations with the AQME toolkit. A total of 211 tool edits were automatically applied to 130 of the 698 total variants reported in an effort to adhere to forensic nomenclature. Although additional manual edits were required for three samples, supplemental tools such as mtDNA haplogroup estimation assisted in identifying and guiding these necessary modifications to the AQME-generated profile. Along with profile generation, AQME reported accurate haplogroups for 18 of the 19 samples analyzed. The single errant haplogroup assignment, although phylogenetically close, identified a bug that only affects partial mitogenome data. Future adjustments to AQME's haplogrouping tool will address this bug as well as enhance the overall scoring strategy to better refine and automate haplogroup assignments. As NGS enables broader use of the mtDNA locus in forensics, the availability of AQME and other forensic-focused mtDNA analysis tools will ease the transition and further support mitogenome analysis within routine casework. Toward this end, the AFMES-AFDIL has utilized the AQME toolbox in conjunction with the CLC Genomics Workbench to successfully validate and implement two NGS mitogenome methods. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Criterion Referenced Tests to Accompany "Artes Latinae," Level 1, Book 1. Tentative Edition.

    ERIC Educational Resources Information Center

    Masciantonio, Rudolph

    These tests are designed to measure the achievement of each pupil at the approximate midpoint of each unit in "Artes Latinae," Level 1, Book 1. They were produced in response to the need expressed by many teachers to provide a means of more frequent evaluation of pupil progress. Tests for 13 units are provided. They supplement the unit tests…

  11. Catalog of Citizenship, Consumer, Law-Related, Values and Character Education Curriculum Materials. Fifth Edition with 1993 Supplement.

    ERIC Educational Resources Information Center

    Utah State Office of Education, Salt Lake City. Statewide Clearinghouse on Law-Related Education.

    This catalog lists the materials that the Utah Statewide Clearinghouse on Law-Related Education loans to teachers and anybody else interested in law-related education (LRE). The catalog provides a table of contents that guides the reader to materials on all aspects of law from the constitution to legislation against drug use and on all aspects of…

  12. A Self-Instructional Course in Student Financial Aid Administration. Module 12: The Campus-Based Programs: SEOG, CWS, and Perkins Loan. Second Edition.

    ERIC Educational Resources Information Center

    Washington Consulting Group, Inc., Washington, DC.

    The twelfth module in a 17-module self-instructional course on student financial aid administration discusses campus-based financial programs. They are SEOG (Supplemental Educational Opportunity Grant), CWS (College Work-Study), and Perkins Loans. It is part of a full course designed for novice financial aid administrators and other institutional…

  13. Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial.

    PubMed

    Gould, Jacqueline F; Treyvaud, Karli; Yelland, Lisa N; Anderson, Peter J; Smithers, Lisa G; Gibson, Robert A; McPhee, Andrew J; Makrides, Maria

    2016-05-17

    Despite recommendations that pregnant women increase their docosahexaenoic acid (DHA) intake to support fetal brain development, a recent systematic review found a lack of high-quality data to support the long-term effects of DHA supplementation on children's neurodevelopment. We will assess child neurodevelopment at 7 years of age in follow-up of a multicentre double-blind randomised controlled trial of DHA supplementation in pregnancy. In 2010-2012, n=2399 Australian women with a singleton pregnancy <21 weeks' gestation were randomised to receive 3 capsules daily containing a total dose of 800 mg DHA/day or a vegetable oil placebo until birth. N=726 children from Adelaide (all n=97 born preterm, random sample of n=630 born at term) were selected for neurodevelopmental follow-up and n=638 (preterm n=85) are still enrolled at 7 years of age. At the 7-year follow-up, a psychologist will assess the primary outcome, IQ, with the Wechsler Abbreviated Scale of Intelligence, Second Edition. Specific measures of executive functioning (Fruit Stroop and the Rey Complex Figure), attention (Test of Everyday Attention for Children), memory and learning (Rey Auditory Verbal Learning Test), language (Clinical Evaluation of Language Fundamentals, Fourth Edition) and basic educational skills (Wide Range Achievement Test, Fourth Edition) will also be administered. Caregivers will be asked to complete questionnaires measuring behaviour and executive functioning. Families, clinicians and research personnel are blinded to group assignment with the exception of families who requested unblinding prior to the follow-up. All analyses will be conducted according to the intention-to-treat principal. All procedures will be approved by the relevant institutional ethics committees prior to start of the study. The results of this study will be disseminated in peer-reviewed journal publications and academic presentations. ACTRN12605000569606 and ACTRN12614000770662. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  14. Commercial and Industrial Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook 1 [and] Student Workbook 2.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; Flowers, Gary

    Commercial and Industrial Wiring, third in a series of three wiring publications, includes the additional technical knowledge and applications required for job entry in the commercial and industrial wiring trade. Instructional materials include a teacher edition, student guide, and two student workbooks. The teacher edition begins with…

  15. Predictors of Performance on the MMSE and the DRS-2 Among American Indian Elders

    PubMed Central

    Jervis, Lori L.; Fickenscher, Alexandra; Beals, Janette; Cullum, C. Munro; Novins, Douglas K.; Manson, Spero M.; Arciniegas, David B.

    2015-01-01

    Little is known about factors that predict older American Indians’ performance on cognitive tests. This study examined 137 American Indian elders’ performance on the MMSE and the Dementia Rating Scale—Second Edition (DRS-2). Multivariate regression identified younger age, more education, not receiving Supplemental Security Income, and frequent receipt of needed health care as predictors of better performance on the MMSE. Better performance on the DRS-2 was predicted by more education, boarding school attendance, not receiving Supplemental Security Income, and frequent receipt of needed health care. This study points to the importance of economic and educational factors on cognitive test performance among American Indian elders. PMID:21037127

  16. Predictors of performance on the MMSE and the DRS-2 among American Indian elders.

    PubMed

    Jervis, Lori L; Fickenscher, Alexandra; Beals, Janette; Cullum, C Munro; Novins, Douglas K; Manson, Spero M; Arciniegas, David B

    2010-01-01

    Little is known about factors that predict older American Indians' performance on cognitive tests. This study examined 137 American Indian elders' performance on the MMSE and the Dementia Rating Scale-Second Edition (DRS-2). Multivariate regression identified younger age, more education, not receiving Supplemental Security Income, and frequent receipt of needed health care as predictors of better performance on the MMSE. Better performance on the DRS-2 was predicted by more education, boarding school attendance, not receiving Supplemental Security Income, and frequent receipt of needed health care. This study points to the importance of economic and educational factors on cognitive test performance among American Indian elders.

  17. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Terra-FM1_Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-11-02] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  18. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Aqua-FM4_Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-04-02] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  19. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Terra-FM1_Edition1-CV)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-11-02] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  20. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Terra-FM2_Edition2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-01-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  1. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Aqua-FM3_Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-11-02] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  2. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_TRMM-PFM_Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2000-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  3. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Aqua-FM4_Edition2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  4. CERES BiDirectional Scans (BDS) data in HDF (CER_BDS_Aqua-FM3_Edition2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    Each BiDirectional Scans (BDS) data product contains twenty-four hours of Level-1b data for each CERES scanner instrument mounted on each spacecraft. The BDS includes samples taken in normal and short Earth scan elevation profiles in both fixed and rotating azimuth scan modes (including space, internal calibration, and solar calibration views). The BDS contains Level-0 raw (unconverted) science and instrument data as well as the geolocated converted science and instrument data. The BDS contains additional data not found in the Level-0 input file, including converted satellite position and velocity data, celestial data, converted digital status data, and parameters used in the radiance count conversion equations. The following CERES BDS data sets are currently available: CER_BDS_TRMM-PFM_Edition1 CER_BDS_Terra-FM1_Edition1 CER_BDS_Terra-FM2_Edition1 CER_BDS_Terra-FM1_Edition2 CER_BDS_Terra-FM2_Edition2 CER_BDS_Aqua-FM3_Edition1 CER_BDS_Aqua-FM4_Edition1 CER_BDS_Aqua-FM3_Edition2 CER_BDS_Aqua-FM4_Edition2 CER_BDS_Aqua-FM3_Edition1-CV CER_BDS_Aqua-FM4_Edition1-CV CER_BDS_Terra-FM1_Edition1-CV CER_BDS_Terra-FM2_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-01-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  5. NIOSH Manual of Analytical Methods (third edition). Fourth supplement

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1990-08-15

    The NIOSH Manual of Analytical Methods, 3rd edition, was updated for the following chemicals: allyl-glycidyl-ether, 2-aminopyridine, aspartame, bromine, chlorine, n-butylamine, n-butyl-glycidyl-ether, carbon-dioxide, carbon-monoxide, chlorinated-camphene, chloroacetaldehyde, p-chlorophenol, crotonaldehyde, 1,1-dimethylhydrazine, dinitro-o-cresol, ethyl-acetate, ethyl-formate, ethylenimine, sodium-fluoride, hydrogen-fluoride, cryolite, sodium-hexafluoroaluminate, formic-acid, hexachlorobutadiene, hydrogen-cyanide, hydrogen-sulfide, isopropyl-acetate, isopropyl-ether, isopropyl-glycidyl-ether, lead, lead-oxide, maleic-anhydride, methyl-acetate, methyl-acrylate, methyl-tert-butyl ether, methyl-cellosolve-acetate, methylcyclohexanol, 4,4'-methylenedianiline, monomethylaniline, monomethylhydrazine, nitric-oxide, p-nitroaniline, phenyl-ether, phenyl-ether-biphenyl mixture, phenyl-glycidyl-ether, phenylhydrazine, phosphine, ronnel, sulfuryl-fluoride, talc, tributyl-phosphate, 1,1,2-trichloro-1,2,2-trifluoroethane, trimellitic-anhydride, triorthocresyl-phosphate, triphenyl-phosphate, and vinyl-acetate.

  6. Encyclopedia of Smart Materials, 2 Volume Set

    NASA Astrophysics Data System (ADS)

    Schwartz, Mel

    2002-03-01

    Smart materials--materials and structures that can impart information about their environment to an observer or monitoring device--are revolutionizing fields as diverse as engineering, optics, and medical technology. Advances in smart materials are impacting disciplines across the scientific and technological landscape. Now, practictioners and researchers have an authoritative source to go to for answers about this emerging new area. Encyclopedia of Smart Materials provides A-to-Z coverage of the entire field of intelligent materials. Discussions of theory, fabrication, processing, applications, and uses of these unique materials are presented here in a collection of concise entries from the world's foremost experts in the field--including scientists, educators and engineers. This encyclopedia is as broad in scope as the technology itself, addressing daily, commercial applications as well as sophisticated units designed to operate in space, underwater, underground, and within the human body. Extensively cross-referenced and generously supplemented with bibliographies and indexes, this book's treatment also broaches the specialized properties and coatings that are required for the use of materials in extreme conditions. Illustrated with photographs, tables, line drawings, and equations, Encyclopedia of Smart Materials is the premier reference for material scientists, chemists, chemical engineers, process engineers, consultants, patent attorneys and students in these areas. An essential resource on the shelves of laboratories, government facilities, and academic libraries. Editor-in-Chief, Mel Schwartz has over forty years of experience with metals, ceramics, and composites, with special expertise in brazing. The holder of five patents, he has authored thirteen books and more than one hundred technical papers and articles. Reach the information you need rapidly and easily with the ONLINE edition of the Encyclopedia of Smart Materials. The online edition delivers all the rich content of the print edition with the added benefits of an advanced search engine and the desktop convenience of web access. For more information or to license the online edition (beginning July 2002) please visit: www.interscience.wiley.com/reference/esm

  7. Introduction to Surgical Technology. Third Edition. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Bushey, Vicki; Hildebrand, Bob; Hildebrand, Dinah; Johnson, Dave; Sikes, John; Tahah, Ann; Walker, Susan; Zielsdorf, Lani

    These teacher and student editions provide instructional materials for an introduction to surgical technology course. Introductory materials in the teacher edition include information on use, instructional/task analysis, academic and workplace skill classifications and definitions, related academic and workplace skill list, and crosswalk to…

  8. Plant-Derived Terpenes: A Feedstock for Specialty Biofuels.

    PubMed

    Mewalal, Ritesh; Rai, Durgesh K; Kainer, David; Chen, Feng; Külheim, Carsten; Peter, Gary F; Tuskan, Gerald A

    2017-03-01

    Research toward renewable and sustainable energy has identified specific terpenes capable of supplementing or replacing current petroleum-derived fuels. Despite being naturally produced and stored by many plants, there are few examples of commercial recovery of terpenes from plants because of low yields. Plant terpene biosynthesis is regulated at multiple levels, leading to wide variability in terpene content and chemistry. Advances in the plant molecular toolkit, including annotated genomes, high-throughput omics profiling, and genome editing, have begun to elucidate plant terpene metabolism, and such information is useful for bioengineering metabolic pathways for specific terpenes. We review here the status of terpenes as a specialty biofuel and discuss the potential of plants as a viable agronomic solution for future terpene-derived biofuels. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Coping With Droughts

    NASA Astrophysics Data System (ADS)

    Zaporozec, Alexander

    This book is a collection of selected papers from the NATO Advanced Study Institute on Droughts entitled “Drought Impact Control Technology,” held at the National Laboratory of Civil Engineering in Lisbon, Portugal, in June 1980. The editors of the book have chosen a nontraditional but successful approach to presenting the papers. Instead of including a verbatim proceedings of the institute, they assembled 21 papers presented by 14 of the institute's lecturers, reshaped and synthesized them, and supplemented them by five new papers that cover obvious gaps in topics. The result is enlightening reading and a more or less complete presentation of the subject. The edited material in the book was arranged around three central themes related to efforts needed to cope with or manage the droughts. In the process, the identity of individual contributors has been preserved.

  10. Gas Tungsten Arc Welding and Plasma Arc Cutting. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    ERIC Educational Resources Information Center

    Harper, Eddie; Knapp, John

    This packet of instructional materials for a gas tungsten arc welding (GTAW) and plasma arc cutting course is comprised of a teacher edition, student edition, and student workbook. The teacher edition consists of introductory pages and teacher pages. Introductory pages include training and competency profile, state duty/task crosswalk,…

  11. Use of a fluoride channel as a new selection marker for fission yeast plasmids and application to fast genome editing with CRISPR/Cas9

    PubMed Central

    Fernandez, Ronan; Berro, Julien

    2017-01-01

    Fission yeast is a powerful model organism that has provided insights into important cellular processes thanks to the ease of its genome editing by homologous recombination. However, creation of strains with a large number of targeted mutations or containing plasmids has been challenging because only a very small number of selection markers is available in Schizosaccharomyces pombe. In this paper, we identify two fission yeast fluoride exporter channels (Fex1p and Fex2p) and describe the development of a new strategy using Fex1p as a selection marker for transformants in rich media supplemented with fluoride. To our knowledge this is the first positive selection marker identified in S. pombe that does not use auxotrophy or drug resistance and that can be used for plasmids transformation or genomic integration in rich media. We illustrate the application of our new marker by significantly accelerating the protocol for genome edition using CRISPR/Cas9 in S. pombe. PMID:27327046

  12. Accounting Clerk Guide, Instructor Packet--Part I. A Spec Unit for the 10th, 11th, or 12th Grade. A Career Education Unit (An Edited Developmental Draft).

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The instructor packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing students for entry into the occupation of accounting clerk. The instructor packet lists performance objectives, vocabulary, learning tasks, and supplemental activities for lessons 1 through 11. It also includes…

  13. Volunteering and Giving among American Teenagers 14 to 17 Years of Age. Findings from a National Survey. 1990 Edition.

    ERIC Educational Resources Information Center

    Hodgkinson, Virginia A.; Weitzman, Murray S.

    This survey was conducted by the Gallup organization on the volunteering and giving behavior of U.S. teenagers as a supplement to a national survey on giving and volunteering among U.S. adults. Information was obtained from in-home personal interviews with 301 teenagers from 14 to 17 years of age. Results indicated that 58 percent of teenagers…

  14. Building America Top Innovations 2012: Building Science-Based Climate Maps

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    none,

    2013-01-01

    This Building America Top Innovations profile describes the Building America-developed climate zone map, which serves as a consistent framework for energy-efficiency requirements in the national model energy code starting with the 2004 IECC Supplement and the ASHRAE 90.1 2004 edition. The map also provides a critical foundation for climate-specific guidance in the widely disseminated EEBA Builder Guides and Building America Best Practice Guides.

  15. Effect of multivitamin supplementation on the neurodevelopment of HIV-exposed Tanzanian infants: a randomized, double-blind, placebo-controlled clinical trial.

    PubMed

    Manji, Karim P; McDonald, Christine M; Kupka, Roland; Bosch, Ronald J; Kisenge, Rodrick; Aboud, Said; Bellinger, David C; Fawzi, Wafaie W; Duggan, Christopher P

    2014-08-01

    Micronutrient deficiencies and in utero exposure to HIV may impair infant neurodevelopment. To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants. A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months. Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = -0.01, 0.78, p = 0.06). Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  16. [Characteristics of acupuncture textbooks on editing mode and content in the Republic of China].

    PubMed

    Zhao, Jing; Zhang, Shujian

    2017-09-12

    Sixty-seven textbooks in the Republic of China have been collected and divided into three stages according to their editing modes, named the early stage (1912-1927), the middle stage (1928-1939) and the late stage (1940-1949). The traditional teaching material of acupuncture was predominated at the early stage in the textbook compilation; meanwhile the editing mode was simple, and the content of it focuses on meridians, collaterals and acupoints and the modern scientific theories have been preliminarily introduced. The textbooks at the middle stage were edited as two modes, "western medicine+acupuncture" and "general introduction→meridian points→manipulation (techniques of acupuncture and moxibustion)→treatment". The knowledge in anatomy, physiology and pathology of western medicine has been involved in content, giving the great consideration to the clinical practicability. However, a part of textbooks still followed the traditional theory of acupuncture at the middle stage. At the late stage, the textbooks were edited align with "acupuncture science, moxibustion science, meridian point science and treatment science"; or in supplementation of the "diagnosis" on the base of "general introduction→ meridian points→techniques of acupuncture→treatment", or edited as "general introduction→points→treatment". The compilation of the textbooks at this stage not only followed but also improved the integration of western and Chinese medicine as that at the middle stage, which turned to be more scientific. Additionally, in the teaching content, the acupoint was much more considerable as compared with pulse and the section of diagnosis has been involved. As a result, a framework of acupuncture discipline has been established preliminarily by taking acupuncture technique, moxibustion technique, acupoints and treatment as the core. The development of the editing mode and content of textbooks played a great impact on the unified compilation of the acupuncture textbooks after the foundation of China.

  17. Major Appliance Repair. Teacher Edition and Student Edition. Second Edition.

    ERIC Educational Resources Information Center

    Smreker, Gene; Calvert, King

    This second edition contains teacher and student guides for 14 units of instruction in major appliance repair. Each unit in the teacher edition includes some or all of the following basic components: objective sheet, suggested activities, answers to assignment sheets, answers to the written test, written test, a unit evaluation form, teacher…

  18. Genome editing in livestock: Are we ready for a revolution in animal breeding industry?

    PubMed

    Ruan, Jinxue; Xu, Jie; Chen-Tsai, Ruby Yanru; Li, Kui

    2017-12-01

    Genome editing is a powerful technology that can efficiently alter the genome of organisms to achieve targeted modification of endogenous genes and targeted integration of exogenous genes. Current genome-editing tools mainly include ZFN, TALEN and CRISPR/Cas9, which have been successfully applied to all species tested including zebrafish, humans, mice, rats, monkeys, pigs, cattle, sheep, goats and others. The application of genome editing has quickly swept through the entire biomedical field, including livestock breeding. Traditional livestock breeding is associated with rate limiting issues such as long breeding cycle and limitations of genetic resources. Genome editing tools offer solutions to these problems at affordable costs. Generation of gene-edited livestock with improved traits has proven feasible and valuable. For example, the CD163 gene-edited pig is resistant to porcine reproductive and respiratory syndrome (PRRS, also referred to as "blue ear disease"), and a SP110 gene knock-in cow less susceptible to tuberculosis. Given the high efficiency and low cost of genome editing tools, particularly CRISPR/Cas9, it is foreseeable that a significant number of genome edited livestock animals will be produced in the near future; hence it is imperative to comprehensively evaluate the pros and cons they will bring to the livestock breeding industry. Only with these considerations in mind, we will be able to fully take the advantage of the genome editing era in livestock breeding.

  19. Methodology: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement.

    PubMed

    Ornelas, Joe; Dichter, Jeffrey R; Devereaux, Asha V; Kissoon, Niranjan; Livinski, Alicia; Christian, Michael D

    2014-10-01

    Natural disasters, industrial accidents, terrorism attacks, and pandemics all have the capacity to result in large numbers of critically ill or injured patients. This supplement provides suggestions for all those involved in a disaster or pandemic with multiple critically ill patients, including front-line clinicians, hospital administrators, professional societies, and public health or government officials. The field of disaster medicine does not have the required body of evidence needed to undergo a traditional guideline development process. In result, consensus statement-development methodology was used to capture the highest-caliber expert opinion in a structured, scientific approach. Task Force Executive Committee members identified core topic areas regarding the provision of care to critically ill or injured patients from pandemics or disasters and subsequently assembled an international panel for each identified area. International disaster medicine experts were brought together to identify key questions (in a population, intervention, comparator, outcome [PICO]-based format) within each of the core topic areas. Comprehensive literature searches were then conducted to identify studies upon which evidence-based recommendations could be made. No studies of sufficient quality were identified. Therefore, the panel developed expert opinion-based suggestions that are presented in this supplement using a modified Delphi process. A total of 315 suggestions were drafted across all topic groups. After two rounds of a Delphi consensus-development process, 267 suggestions were chosen by the panel to include in the document and published in a total of 12 manuscripts composing the core chapters of this supplement. Draft manuscripts were prepared by the topic editor and members of the working groups for each of the topics, producing a total of 11 papers. Once the preliminary drafts were received, the Executive Committee (Writing Committee) then met to review, edit, and promote alignment of all of the primary drafts of the manuscripts prepared by the topic editors and their groups. The topic editors then revised their manuscripts based on the Executive Committee's edits and comments. The Writing Committee subsequently reviewed the updated drafts and prepared the final manuscripts for submission to the Guidelines Oversight Committee (GOC). The manuscripts subsequently underwent review by the GOC, including external review as well as peer review for the journal publication. The Writing Committee received the feedback from the reviewers and modified the manuscripts as required. Based on a robust and transparent process, this project used rigorous methodology to produce clinically relevant, trustworthy consensus statements, with the aim to provide needed guidance on treatment and procedures for practitioners, hospital administrators, and public health and government officials when addressing the care of critically ill or injured patients in disasters or pandemics.

  20. Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    ERIC Educational Resources Information Center

    Knapp, John; Harper, Eddie

    This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

  1. Thirty-eighth supplement to the American Ornithologists' Union Check-list of North American birds

    USGS Publications Warehouse

    Monroe, Burt L.; Banks, Richard C.; Fitzpatrick, John W.; Howell, Thomas R.; Johnson, Ned K.; Ouellet, Henri; Remsen, J.V.; Storer, Robert W.

    1991-01-01

    This fourth supplement after the 6th edition (1983) of the AOU "Check-list of North American Birds" consists of changes adopted by the Committee on Classification and Nomenclature between 1 March 1989 and 1 March 1991. The changes fall into eight categories: (1) five species (Ixobrychus sinensis, Porphyrula flavirostris, Sterna bergii, Streptopelia orientalis, and Ficedula narcissina) are added to the main list because of new distributional information; (2) six species (Pterodroma cervicalis, Ortalis wagleri, Lophornis brachylopha, Corvus sinaloae, Cinclocerthia gutturalis, and Loxops caeruleirostris) are added to the list because of the splitting of species previously in the list; (3) one extinct species (Dysmorodrepanis munroi) is added to the list because of re-identification of the unique type; (4) one scientific name (Speotyto cunicularia) is changed because of generic splitting; (5) one scientific name (Phalacrocorax brasilianus) is changed for nomenclature reasons, accompanied by a change in English name; (6) the spelling of one scientific name (Neocrex colombianus) is corrected; (7) to other English names are changed or corrected; and (8) one sequencing change is made. No new distributional information is included except as noted above (i.e. minor changes of distribution of distributional records within North America are not included). The twelve additions bring the number of species recognized as occurring within the Check-list area (main list) to 1957.

  2. 76 FR 49237 - Energy Conservation Program: Test Procedures for Residential Clothes Washers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ...In this supplemental notice of proposed rulemaking (SNOPR), the U.S. Department of Energy (DOE) proposes to revise its test procedure for residential clothes washers established under the Energy Policy and Conservation Act (EPCA). DOE proposes to incorporate provisions of the International Electrotechnical Commission (IEC) Standard 62301, ``Household electrical appliances--Measurement of standby power'' (Second Edition). DOE also proposes to update the provisions for measuring active mode energy and water consumption.

  3. Chicano Studies Bibliography: A Guide to the Resources of the Library at the University of Texas at El Paso. Supplement to 3rd Edition, 1974-75.

    ERIC Educational Resources Information Center

    Marquez, Benjamin, Ed.

    Compiled to facilitate research in the field of Chicano Studies, this bibliography cites approximately 197 books and periodical articles published between 1937 and 1974. This bibliography is intended as a guide to select items which are part of the Chicano Materials Collection at the University of Texas at El Paso. Arranged alphabetically by the…

  4. BOOK REVIEW: The Complete A-Z Physics Handbook, Second Edition

    NASA Astrophysics Data System (ADS)

    Breithaupt, Jim

    2000-11-01

    The first edition of this book was published in 1997 and reviewed in Physics Education in March 1988. This second edition is 13 pages longer and contains a significant number of new entries, mostly in particle physics and astrophysics, to match the latest AS/A-level specifications. Some entries on topics such as surface tension that were removed from previous AS/A-level syllabuses have now been deleted. The revised book thus provides an effective alphabetical guide to key terms used in the latest AS/A-level specifications as most AS/A-level core terms are included, apart from terms for some of the new topics such as image processing in the new IOP AS/A-level specification. The style of the second edition is the same as the first, each entry commencing with the key term in bold print followed by an explanation of the term, accompanied by the relevant equation and/or a simple diagram where appropriate. Cross-references are given in italics. For example, the entry under quarks (which is one of the new entries) lists the six quarks and their characteristic properties in bullet point format then follows up with the information about the quark composition of baryons and mesons, giving the composition of the proton, the neutron and the pions as examples. The change of quark composition due to beta decay is mentioned with a cross-reference to beta decay. Other cross-references link to entries on the proton, the neutron and the four fundamental interactions. Lengthy entries such as the photoelectric effect each cover several pages, thus providing opportunities for in-depth revision. Useful theme entries provided in the first edition have been retained and referred to in a new two-page appendix on preparing for synoptic questions. Some proofs are provided such as the proof of the kinetic theory equation. Some experiments are described, each under an appropriate entry. Technically, the entries are reasonably accurate and usually expressed in appropriate and familiar language. The book ends with the same appendices as in the first edition (units, formulae, physical constants, examiners' terms, a suggested revision list and notes on examination preparation) plus the two-page synoptic appendix. The second edition with its additional entries on particle physics and astrophysics should prove useful as a study guide to supplement a textbook or as a revision guide as AS or A2 examinations approach. In addition, the concise nature of many of the entries could be valuable in helping physics students sharpen their written communication skills, thereby securing marks which all too often they lose on account of inadequate answers to descriptive questions.

  5. Developmental Outcomes at 24 Months of Age in Toddlers Supplemented with Arachidonic Acid and Docosahexaenoic Acid: Results of a Double Blind Randomized, Controlled Trial

    PubMed Central

    Devlin, Angela M.; Chau, Cecil M. Y.; Matheson, Julie; McCarthy, Deanna; Yurko-Mauro, Karin; Innis, Sheila M.; Grunau, Ruth E.

    2017-01-01

    Little is known about arachidonic acid (ARA) and docosahexaenoic acid (DHA) requirements in toddlers. A longitudinal, double blind, controlled trial in toddlers (n = 133) age 13.4 ± 0.9 months (mean ± standard deviation), randomized to receive a DHA (200 mg/day) and ARA (200 mg/day) supplement (supplement) or a corn oil supplement (control) until age 24 months determined effects on neurodevelopment. We found no effect of the supplement on the Bayley Scales of Infant and Toddler Development 3rd Edition (Bayley-III) cognitive and language composites and Beery–Buktenica Developmental Test of Visual–Motor Integration (Beery VMI) at age 24 months. Supplemented toddlers had higher RBC phosphatidylcholine (PC), phosphatidylethanolamine (PE), and plasma DHA and ARA compared to placebo toddlers at age 24 months. A positive relationship between RBC PE ARA and Bayley III Cognitive composite (4.55 (0.21–9.00), B (95% CI), p = 0.045) in supplemented boys, but not in control boys, was observed in models adjusted for baseline fatty acid, maternal non-verbal intelligence, and BMI z-score at age 24 months. A similar positive relationship between RBC PE ARA and Bayley III Language composite was observed for supplemented boys (11.52 (5.10–17.94), p < 0.001) and girls (11.19 (4.69–17.68), p = 0.001). These findings suggest that increasing the ARA status in toddlers is associated with better neurodevelopment at age 24 months. PMID:28878181

  6. Summary of SPT based field case history data of CETIN (2016) database

    USGS Publications Warehouse

    Onder Cetin, K.; Seed, Raymond B.; Kayen, Robert E.; Moss, Robb E. S.; Bilge, H. Tolga; Ilgac, Makbule; Chowdhury, Khaled

    2016-01-01

    This report provides documentation of the Cetin et al. (2016) field performance case histories, probabilistic maximum likelihood assessment and the sources of differences between the liquefaction triggering resistance estimations (CRR values) of the widely used liquefaction triggering relationships of Seed et al. (1985), Cetin et al. (2004, 2016) and Boulanger and Idriss (2012). Cetin et al. (2016-a) presented a concise summary of the improved database and the updated triggering relationships. For the sake of completeness, as part of Chapter 2 of this report, Cetin et al. (2016-a) manuscript is re-presented, as edited to include the electronic supplements, and a broader and more detailed documentation of all of case histories. This broader and more detailed documentation along with the interpretations of other researchers is presented in Appendix A. Similarly, site response analyses details and results from Cetin (2000) is re-presented in Appendix B. To enable the readers to quickly refer to Cetin and Seed (2004), it is also included in Appendix C. The sources of differences between the liquefaction triggering resistance estimations (CRR values) of the widely used liquefaction triggering relationships of Seed et al. (1985), Cetin et al. (2004) and Boulanger and Idriss (2012) were discussed in Cetin et al. (2016-b). Again, for the sake of completeness, as part of Chapter 3 of this report, Cetin et al. (2016-b) manuscript is re-presented, as edited to the include of electronic supplements, and a detailed response to issues addressed by Idriss and Boulanger (2012). Also, the technical response letter (Cetin, 2014) prepared at the request of the members of the NRC Committee on the State of the Art and Practice in Earthquake Induced Soil Liquefaction Assessment, is given in Appendix D, which is helpful to follow the technical discussions. This report is intended only as a concise summary of a vast amount of data. The interpretations presented are those of the research team. A more detailed description of some of the details of the methods and procedures used to evaluate and analyze these field performance case histories is also presented in Cetin (2000) and Cetin et al. (2000) though the final evaluations presented in this report are the most recent interpretations undertaken under these current studies.

  7. Applications of the TIROS-N sounding and cloud motion wind enhancement for the FGGE 'special effort'. [Global Weather Experiment

    NASA Technical Reports Server (NTRS)

    Atlas, R.

    1980-01-01

    In January of 1978, a panel of experts recommended that a 'special effort' be made to enhance and edit satellite soundings and cloud tracked winds in data sparse regions. It was felt that these activities would be necessary to obtain maximum benefits from an evaluation of satellite data during the Global Weather Experiment (FGGE). The 'special effort' is being conducted for the two special observing periods of FGGE. More than sixty cases have been selected for enhancement on the basis of meteorological interest. These cases include situations of blocking, cutoff low development, cyclogenesis, and tropical circulations. The sounding data enhancement process consists of supplementing the operational satellite sounding data set with higher resolution soundings in meteorologically active regions, and with new soundings where data voids or soundings of questionable quality exist.

  8. A study of low scores in Canadian children and adolescents on the Wechsler Intelligence Scale For Children, Fourth Edition (WISC-IV).

    PubMed

    Brooks, Brian L

    2011-01-01

    Knowing the prevalence of low neurocognitive scores for the WISC-IV Canadian normative sample (WISC-IV(CDN)) is an important supplement for clinical interpretation of test performance. On the WISC-IV(CDN), it is uncommon for children and adolescents to have 4 or more subtest scores or 2 or more Index scores ≤ 9th percentile when all scores on the battery are considered simultaneously. As the level of the child's intelligence increases or the number of years of parental education increases, the prevalence of low scores decreases. These results are consistent with existing studies of the base rates of low scores in children and adolescents on pediatric cognitive batteries, including the WISC-IV American normative sample. Tables provided are ready for clinical use.

  9. Controlled flexibility in technical editing - The levels-of-edit concept at JPL

    NASA Technical Reports Server (NTRS)

    Buehler, M. F.

    1977-01-01

    The levels-of-edit concept, which can be used to specify the amount of editorial effort involved in the preparation of a manuscript for publication, is discussed. Nine types of editing are identified and described. These include coordination edit (preparing estimates, gathering cost data, monitoring production processes), policy edit, integrity edit (making sure that parts of a publication match in a physical or numerical sense), screening edit (ensuring that the quality of camera-ready copy is sufficient for external publication), copy clarification edit, format edit, mechanical style edit, language edit, and substantive edit (reviewing the manuscript for content coherence, emphasis, subordination and parallelism). These functions are grouped into five levels of edit. An edit-level number is assigned to each manuscript, providing a quantitative and qualitative indicator of the editing to be done which is clearly understood by authors, managers, and editors alike. In addition, clear boundaries are drawn between normal and extraordinary editing tasks. Individual organizations will group various edits in different ways to reflect their needs and priorities; the essential element of the system is unambiguous definition and coding of the types and amount of work to be done.

  10. Documentation for the machine-readable version of the Henry Draper Catalogue (edition 1985)

    NASA Technical Reports Server (NTRS)

    Roman, N. G.; Warren, W. H., Jr.

    1985-01-01

    An updated, corrected and extended machine-readable version of the catalog is described. Published and unpublished errors discovered in the previous version was corrected; letters indicating supplemental stars in the BD have been moved to a new byte to distinguish them from double-star components; and the machine readable portion of The Henry Draper Extension (HDE) (HA 100) was converted to the same format as the main catalog, with additional data added as necessary.

  11. A Relative Ranking Approach for Nano-Enabled Applications to Improve Risk-Based Decision Making: A Case Study of Army Materiel

    DTIC Science & Technology

    2014-12-24

    scenarios. The USACEHR has been conducting research and devel- opment efforts on the incorporation of various ENMs into Army materiel, ranging from food ...materiel characteristics, and (3) apply the algorithm and associated risk ranking tool to prioritize additional assessments based on the human health risk...online correspondence to confirm, edit, and supplement the inventory with additional information (See Section 1 in Supplementary Information (SI) for

  12. NASA thesaurus aeronautics vocabulary

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The controlled vocabulary used by the NASA Scientific and Technical Information effort to index documents in the area of aeronautics is presented. The terms comprise a subset of the 1988 edition of the NASA Thesaurus and its supplements issued through the end of 1990. The Aeronautics Vocabulary contains over 4700 terms presented in a hierarchical display format. In addition to aeronautics per se, the vocabulary covers supporting terminology from areas such as fluid dynamics, propulsion engineering, and test facilities and instrumentation.

  13. The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells

    PubMed Central

    Nguyen, Xuan-Nhi; Barateau, Véronique; Wu, Nannan; Berger, Gregory; Cimarelli, Andrea

    2015-01-01

    Two cellular factors are currently known to modulate lentiviral infection specifically in myeloid cells: SAMHD1 and APOBEC3A (A3A). SAMHD1 is a deoxynucleoside triphosphohydrolase that interferes with viral infection mostly by limiting the intracellular concentrations of dNTPs, while A3A is a cytidine deaminase that has been described to edit incoming vDNA. The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs. Here, we have used Vpx and dNs to explore the relationship existing between vDNA cytidine deamination and SAMHD1 during HIV-1 or SIVMAC infection of primary dendritic cells. Our results reveal an interesting inverse correlation between conditions that promote efficient infection of DCs and the extent of vDNA editing that may reflect the different susceptibility of vDNA to cytoplasmic effectors during the infection of myeloid cells. PMID:26496699

  14. Helping Children through Books: A Selected Booklist. Third Revised Edition.

    ERIC Educational Resources Information Center

    Pearl, Patricia

    An update of a bibliotherapy bibliography compiled by the Church and Synagogue Library Association (CSLA) a decade ago, this list includes books intended for children from a preschool to a sixth-grade reading level. Although the first edition included works concerning religion, this edition does not, since those works are already covered in other…

  15. Korean Astronomical Calendar, Chiljeongsan

    NASA Astrophysics Data System (ADS)

    Lee, Eun Hee

    In fifteenth century Korea, there was a grand project for the astronomical calendar and instrument making by the order of King Sejong 世宗 (1418-1450). During this period, many astronomical and calendrical books including Islamic sources in Chinese versions were imported from Ming 明 China, and corrected and researched by the court astronomers of Joseon 朝鮮 (1392-1910). Moreover, the astronomers and technicians of Korea frequently visited China to study astronomy and instrument making, and they brought back useful information in the form of new published books or specifications of instruments. As a result, a royal observatory equipped with 15 types of instrument was completed in 1438. Two types of calendar, Chiljeongsan Naepyeon 七政算內篇 and Chiljeongsan Oepyeon 七政算外篇, based on the Chinese and Islamic calendar systems, respectively, were published in 1444 with a number of calendrical editions such as corrections and example supplements (假令) including calculation methods and results for solar and lunar eclipses.

  16. Genome-wide identification of RNA editing in hepatocellular carcinoma.

    PubMed

    Kang, Lin; Liu, Xiaoqiao; Gong, Zhoulin; Zheng, Hancheng; Wang, Jun; Li, Yingrui; Yang, Huanming; Hardwick, James; Dai, Hongyue; Poon, Ronnie T P; Lee, Nikki P; Mao, Mao; Peng, Zhiyu; Chen, Ronghua

    2015-02-01

    We did whole-transcriptome sequencing and whole-genome sequencing on nine pairs of Hepatocellular carcinoma (HCC) tumors and matched adjacent tissues to identify RNA editing events. We identified mean 26,982 editing sites with mean 89.5% canonical A→G edits in each sample using an improved bioinformatics pipeline. The editing rate was significantly higher in tumors than adjacent normal tissues. Comparing the difference between tumor and normal tissues of each patient, we found 7 non-synonymous tissue specific editing events including 4 tumor-specific edits and 3 normal-specific edits in the coding region, as well as 292 edits varying in editing degree. The significant expression changes of 150 genes associated with RNA editing were found in tumors, with 3 of the 4 most significant genes being cancer related. Our results show that editing might be related to higher gene expression. These findings indicate that RNA editing modification may play an important role in the development of HCC. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Primordial germ cell-mediated transgenesis and genome editing in birds.

    PubMed

    Han, Jae Yong; Park, Young Hyun

    2018-01-01

    Transgenesis and genome editing in birds are based on a unique germline transmission system using primordial germ cells (PGCs), which is quite different from the mammalian transgenic and genome editing system. PGCs are progenitor cells of gametes that can deliver genetic information to the next generation. Since avian PGCs were first discovered in nineteenth century, there have been numerous efforts to reveal their origin, specification, and unique migration pattern, and to improve germline transmission efficiency. Recent advances in the isolation and in vitro culture of avian PGCs with genetic manipulation and genome editing tools enable the development of valuable avian models that were unavailable before. However, many challenges remain in the production of transgenic and genome-edited birds, including the precise control of germline transmission, introduction of exogenous genes, and genome editing in PGCs. Therefore, establishing reliable germline-competent PGCs and applying precise genome editing systems are critical current issues in the production of avian models. Here, we introduce a historical overview of avian PGCs and their application, including improved techniques and methodologies in the production of transgenic and genome-edited birds, and we discuss the future potential applications of transgenic and genome-edited birds to provide opportunities and benefits for humans.

  18. Comparison of different methods for estimating snowcover in forested, mountainous basins using LANDSAT (ERTS) images. [Washington and Santiam River, Oregon

    NASA Technical Reports Server (NTRS)

    Meier, M. J.; Evans, W. E.

    1975-01-01

    Snow-covered areas on LANDSAT (ERTS) images of the Santiam River basin, Oregon, and other basins in Washington were measured using several operators and methods. Seven methods were used: (1) Snowline tracing followed by measurement with planimeter, (2) mean snowline altitudes determined from many locations, (3) estimates in 2.5 x 2.5 km boxes of snow-covered area with reference to snow-free images, (4) single radiance-threshold level for entire basin, (5) radiance-threshold setting locally edited by reference to altitude contours and other images, (6) two-band color-sensitive extraction locally edited as in (5), and (7) digital (spectral) pattern recognition techniques. The seven methods are compared in regard to speed of measurement, precision, the ability to recognize snow in deep shadow or in trees, relative cost, and whether useful supplemental data are produced.

  19. Clinical utility of the Wechsler Adult Intelligence Scale-Fourth Edition after traumatic brain injury.

    PubMed

    Donders, Jacobus; Strong, Carrie-Ann H

    2015-02-01

    The performance of 100 patients with traumatic brain injury (TBI) on the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) was compared with that of 100 demographically matched neurologically healthy controls. Processing Speed was the only WAIS-IV factor index that was able to discriminate between persons with moderate-severe TBI on the one hand and persons with either less severe TBI or neurologically healthy controls on the other hand. The Processing Speed index also had acceptable sensitivity and specificity when differentiating between patients with TBI who either did or did not have scores in the clinically significant range on the Trail Making Test. It is concluded that WAIS-IV Processing Speed has acceptable clinical utility in the evaluation of patients with moderate-severe TBI but that it should be supplemented with other measures to assure sufficient accuracy in the diagnostic process. © The Author(s) 2014.

  20. Criterion validity of the Wechsler Intelligence Scale for Children-Fourth Edition after pediatric traumatic brain injury.

    PubMed

    Donders, Jacobus; Janke, Kelly

    2008-07-01

    The performance of 40 children with complicated mild to severe traumatic brain injury on the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV; Wechsler, 2003) was compared with that of 40 demographically matched healthy controls. Of the four WISC-IV factor index scores, only Processing Speed yielded a statistically significant group difference (p < .001) as well as a statistically significant negative correlation with length of coma (p < .01). Logistic regression, using Processing Speed to classify individual children, yielded a sensitivity of 72.50% and a specificity of 62.50%, with false positive and false negative rates both exceeding 30%. We conclude that Processing Speed has acceptable criterion validity in the evaluation of children with complicated mild to severe traumatic brain injury but that the WISC-IV should be supplemented with other measures to assure sufficient accuracy in the diagnostic process.

  1. Engaging Children's Minds: The Project Approach. Second Edition.

    ERIC Educational Resources Information Center

    Katz, Lilian G.; Chard, Sylvia C.

    Noting that much has happened in the field of early childhood education during the 10 years since publication of the first edition of "The Project Approach," this new edition re-introduces the project approach and suggests applications and examples of the approach in action. Notable additions to this second edition include: (1) two new…

  2. Human Resources Administration: A School-Based Perspective. Fourth Edition

    ERIC Educational Resources Information Center

    Smith, Richard

    2009-01-01

    Enhanced and updated, this Fourth Edition of Richard E. Smith's highly successful text examines the growing role of the principal in planning, hiring, staff development, supervision, and other human resource functions. The Fourth Edition includes new sections on ethics, induction, and the role of the mentor teacher. This edition also introduces…

  3. Genome Editing in the Cricket, Gryllus bimaculatus.

    PubMed

    Watanabe, Takahito; Noji, Sumihare; Mito, Taro

    2017-01-01

    Hemimetabolous, or incompletely metamorphosing, insects are phylogenetically basal and include many beneficial and deleterious species. The cricket, Gryllus bimaculatus, is an emerging model for hemimetabolous insects, based on the success of RNA interference (RNAi)-based gene-functional analyses and transgenic technology. Taking advantage of genome editing technologies in this species would greatly promote functional genomics studies. Genome editing has proven to be an effective method for site-specific genome manipulation in various species. Here, we describe a protocol for genome editing including gene knockout and gene knockin in G. bimaculatus for functional genomics studies.

  4. 36 CFR 1206.22 - What type of proposal is eligible for a publications grant?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... records; (2) Microfilm editions consisting of organized collections of images of original sources, usually... images of original editions. Electronic editions may include transcriptions and/or annotations and other...

  5. The Express-Lane Edit: Making Editing Useful for Young Adolescents

    ERIC Educational Resources Information Center

    Anderson, Jeff

    2008-01-01

    Editing is a powerful tool for writers, but are our methods of teaching it really demonstrating that power for young adolescents? The author, frustrated with students' inability to edit, blames his own approach and, beginning with a grocery store epiphany, works to develop a more effective system. Elements of his successful approach include time…

  6. An independent confirmatory factor analysis of the Wechsler Intelligence Scale for Children-fourth Edition (WISC-IV) integrated: what do the process approach subtests measure?

    PubMed

    Benson, Nicholas; Hulac, David M; Bernstein, Joshua D

    2013-09-01

    The Wechsler intelligence scale for children--fourth edition (WISC-IV) Integrated contains the WISC-IV core and supplemental subtests along with process approach subtests designed to facilitate a process-oriented approach to score interpretation. The purpose of this study was to examine the extent to which WISC-IV Integrated subtests measure the constructs they are purported to measure. In addition to examining the measurement and scoring model provided in the manual, this study also tested hypotheses regarding Cattell-Horn-Carroll abilities that might be measured along with other substantive questions regarding the factor structure of the WISC-IV Integrated and the nature of abilities measured by process approach subtests. Results provide insight regarding the constructs measured by these subtests. Many subtests appear to be good to excellent measures of psychometric g (i.e., the general factor presumed to cause the positive correlation of mental tasks). Other abilities measured by subtests are described. For some subtests, the majority of variance is not accounted for by theoretical constructs included in the scoring model. Modifications made to remove demands such as memory recall and verbal expression were found to reduce construct-irrelevant variance. The WISC-IV Integrated subtests appear to measure similar constructs across ages 6-16, although strict factorial invariance was not supported.

  7. Executive summary: evaluating the evidence base to support the inclusion of infants and children from birth to 24 mo of age in the Dietary Guidelines for Americans—“the B-24 Project”123

    PubMed Central

    Raghavan, Ramkripa; Porter, Alexandra; Obbagy, Julie E; Spahn, Joanne M

    2014-01-01

    The Dietary Guidelines for Americans (DGA) are the cornerstone of US government efforts to promote health and prevent disease through diet and nutrition. The DGA currently provides guidelines for ages ≥2 y. In an effort to determine the strength of the evidence to support the inclusion of infants and children from birth to age 24 mo, the partner agencies led by the Department of Health and Human Services Office of Disease Prevention and Health Promotion and the USDA Center for Nutrition Program and Policy initiated the project entitled “Evaluating the evidence base to support the inclusion of infants and children from birth to 24 months of age in the Dietary Guidelines for Americans—the B-24 Project.” This project represents the first step in the process of applying systematic reviews to the process of deciding whether the evidence is sufficient to include this age group in future editions of the DGA. This supplement includes the B-24 Executive Summary, which describes the B-24 Project and the deliberations of the 4 working groups during the process of developing priority topics for the systematic review, and a research agenda to address the critical gaps. Also included in this supplement issue is an article on the Nutrition Evidence Library methodology for developing systematic review questions and articles from the invited content presenters at the B-24 Prime meeting. PMID:24500158

  8. Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High-Throughput Sequencing in Psychiatric Disorders

    PubMed Central

    Zhu, Hu; Urban, Daniel J.; Blashka, Jared; McPheeters, Matthew T.; Kroeze, Wesley K.; Mieczkowski, Piotr; Overholser, James C.; Jurjus, George J.; Dieter, Lesa; Mahajan, Gouri J.; Rajkowska, Grazyna; Wang, Zefeng; Sullivan, Patrick F.; Stockmeier, Craig A.; Roth, Bryan L.

    2012-01-01

    A-to-I RNA editing is a post-transcriptional modification of single nucleotides in RNA by adenosine deamination, which thereby diversifies the gene products encoded in the genome. Thousands of potential RNA editing sites have been identified by recent studies (e.g. see Li et al, Science 2009); however, only a handful of these sites have been independently confirmed. Here, we systematically and quantitatively examined 109 putative coding region A-to-I RNA editing sites in three sets of normal human brain samples by ultra-high-throughput sequencing (uHTS). Forty of 109 putative sites, including 25 previously confirmed sites, were validated as truly edited in our brain samples, suggesting an overestimation of A-to-I RNA editing in these putative sites by Li et al (2009). To evaluate RNA editing in human disease, we analyzed 29 of the confirmed sites in subjects with major depressive disorder and schizophrenia using uHTS. In striking contrast to many prior studies, we did not find significant alterations in the frequency of RNA editing at any of the editing sites in samples from these patients, including within the 5HT2C serotonin receptor (HTR2C). Our results indicate that uHTS is a fast, quantitative and high-throughput method to assess RNA editing in human physiology and disease and that many prior studies of RNA editing may overestimate both the extent and disease-related variability of RNA editing at the sites we examined in the human brain. PMID:22912834

  9. Journal of Special Operations Medicine. Training Supplement: Tactics, Techniques, and Procedures, Volume 8 Edition 4, Fall 2008

    DTIC Science & Technology

    2008-01-01

    alimentary tract anaerobes (AI). Initial antibacterial activity should not be directed at multidrug-resistant pathogens such as Acinetobacter baumannii...plus 4 isolation beds Ancillary Lab, x-ray 5. LPH, AKA, APA, LST class ships are no longer in active service. 6. Hospital ships (T-AH) may provide...responsibilities and as the supported combatant commander for the Global War on Terrorism (GWOT). USSOCOM is actively engaged in the JLLP, where the goal

  10. Journal of Special Operations Medicine, Volume 7, Edition 4. Training Supplement: Tactics, Techniques, and Procedures

    DTIC Science & Technology

    2007-01-01

    fatigued. The majority of the OIL and TTP listed here are oriented to the Level I management of combat CAX or management at the point of injury (POI) or...carried into the field by medical personnel. Time to evacuation from the POI or other casualty evacuation point (CEP) to an MTF may vary considerably...must be avoided during this time. Care must be rendered once the mission has reached an anticipated evacuation point , without pursuit, awaiting CASEVAC

  11. Interim Data Changes in the Short-term Energy Outlook Data Systems Related to Electric Power Sector and Natural Gas Demand Data Revisions (Short-Term Energy Outlook Supplement December 2002)

    EIA Publications

    2002-01-01

    Beginning with the December 2002 issue of the Energy Information Administration's Short-Term Energy Outlook (STEO), electricity generation and related fuel consumption totals will be presented on a basis that is consistent with the definitions and aggregates used in the 2001 edition of EIA's Annual Energy Review (AER). Particularly affected by these changes are the demand and balancing item totals for natural

  12. Title I ESEA Projects: Digest of Annual Evaluations. Supplementary Edition 1977-1978. A historical summary, by the Department of Federal Evaluation Resources, of the key findings reported in the annual evaluations of each project. Report #7827.

    ERIC Educational Resources Information Center

    Philadelphia School District, PA. Office of Research and Evaluation.

    This supplement provides a historical summary, for the Philadelphia, Pennsylvania schools, of the key findings in the Annual Evaluations of each Elementary Secondary Education Act Title I project since 1975. The 1977-1978 management information, the key findings for 1975-1976 and 1976-1977, as well as the preliminary findings for 1977-1978 are…

  13. A predictive Bayesian approach to the design and analysis of bridging studies.

    PubMed

    Gould, A Lawrence; Jin, Tian; Zhang, Li Xin; Wang, William W B

    2012-09-01

    Pharmaceutical product development culminates in confirmatory trials whose evidence for the product's efficacy and safety supports regulatory approval for marketing. Regulatory agencies in countries whose patients were not included in the confirmatory trials often require confirmation of efficacy and safety in their patient populations, which may be accomplished by carrying out bridging studies to establish consistency for local patients of the effects demonstrated by the original trials. This article describes and illustrates an approach for designing and analyzing bridging studies that fully incorporates the information provided by the original trials. The approach determines probability contours or regions of joint predictive intervals for treatment effect and response variability, or endpoints of treatment effect confidence intervals, that are functions of the findings from the original trials, the sample sizes for the bridging studies, and possible deviations from complete consistency with the original trials. The bridging studies are judged consistent with the original trials if their findings fall within the probability contours or regions. Regulatory considerations determine the region definitions and appropriate probability levels. Producer and consumer risks provide a way to assess alternative region and probability choices. [Supplemental materials are available for this article. Go to the Publisher's online edition of the Journal of Biopharmaceutical Statistics for the following free supplemental resource: Appendix 2: R code for Calculations.].

  14. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors.

    PubMed

    Wright, John M; Vered, Marilena

    2017-03-01

    The 4th edition of the World Health Organization's Classification of Head and Neck Tumours was published in January of 2017. This article provides a summary of the changes to Chapter 4 Tumours of the oral cavity and mobile tongue and Chapter 8 Odontogenic and maxillofacial bone tumours. Odontogenic cysts which were eliminated from the 3rd 2005 edition were included in the 4th edition as well as other unique allied conditons of the jaws. Many new tumors published since 2005 have been included in the 2017 classification.

  15. The Solid Earth

    NASA Astrophysics Data System (ADS)

    Fowler, C. M. R.

    2004-12-01

    The second edition of this acclaimed textbook has been brought fully up-to-date to reflect the latest advances in geophysical research. It is designed for students in introductory geophysics courses who have a general background in the physical sciences, including introductory calculus. New to this edition are a section of color plates and separate sections on the earth's mantle and core. The book also contains an extensive glossary of terms, and includes numerous exercises for which solutions are available to instructors from solutions@cambridge.org. First Edition Hb (1990): 0-521-37025-6 First Edition Pb (1990): 0-521-38590-3

  16. The Solid Earth

    NASA Astrophysics Data System (ADS)

    Fowler, C. M. R.

    2005-02-01

    The second edition of this acclaimed textbook has been brought fully up-to-date to reflect the latest advances in geophysical research. It is designed for students in introductory geophysics courses who have a general background in the physical sciences, including introductory calculus. New to this edition are a section of color plates and separate sections on the earth's mantle and core. The book also contains an extensive glossary of terms, and includes numerous exercises for which solutions are available to instructors from solutions@cambridge.org. First Edition Hb (1990): 0-521-37025-6 First Edition Pb (1990): 0-521-38590-3

  17. Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.

    PubMed

    Uno, Narumi; Abe, Satoshi; Oshimura, Mitsuo; Kazuki, Yasuhiro

    2018-02-01

    Chromosome transfer technology, including chromosome modification, enables the introduction of Mb-sized or multiple genes to desired cells or animals. This technology has allowed innovative developments to be made for models of human disease and humanized animals, including Down syndrome model mice and humanized transchromosomic (Tc) immunoglobulin mice. Genome editing techniques are developing rapidly, and permit modifications such as gene knockout and knockin to be performed in various cell lines and animals. This review summarizes chromosome transfer-related technologies and the combined technologies of chromosome transfer and genome editing mainly for the production of cell/animal models of human disease and humanized animal models. Specifically, these include: (1) chromosome modification with genome editing in Chinese hamster ovary cells and mouse A9 cells for efficient transfer to desired cell types; (2) single-nucleotide polymorphism modification in humanized Tc mice with genome editing; and (3) generation of a disease model of Down syndrome-associated hematopoiesis abnormalities by the transfer of human chromosome 21 to normal human embryonic stem cells and the induction of mutation(s) in the endogenous gene(s) with genome editing. These combinations of chromosome transfer and genome editing open up new avenues for drug development and therapy as well as for basic research.

  18. Basic Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook 1 [and] Student Workbook 2.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; Flowers, Gary; Blasingame, Don

    Basic Wiring, first in a series of three wiring publications, serves as the foundation for students enrolled in a wiring program. It is a prerequisite to Commercial and Industrial Wiring or Residential Wiring. Instructional materials include a teacher edition, student guide, and two student workbooks. The teacher edition begins with introductory…

  19. Shielded Metal Arc Welding and Carbon Arc Cutting--Air. Teacher Edition [and] Student Edition [and] Student Workbook. Third Edition.

    ERIC Educational Resources Information Center

    Harper, Eddie; Knapp, John

    This document contains the teacher and student texts and student workbook for a secondary-level course in shielded metal arc welding (SMAW) and carbon arc cutting that consists of units on the following topics: SMAW safety; SMAW equipment, applications, and techniques; hardfacing; and carbon arc cutting--air. The teacher edition includes the…

  20. Software tools for developing an acoustics multimedia CD-ROM

    NASA Astrophysics Data System (ADS)

    Bigelow, Todd W.; Wheeler, Paul A.

    2003-10-01

    A multimedia CD-ROM was developed to accompany the textbook, Science of Sound, by Tom Rossing. This paper discusses the multimedia elements included in the CD-ROM and the various software packages used to create them. PowerPoint presentations with an audio-track background were converted to web pages using Impatica. Animations of acoustic examples and quizzes were developed using Flash by Macromedia. Vegas Video and Sound Forge by Sonic Foundry were used for editing video and audio clips while Cleaner by Discreet was used to compress the clips for use over the internet. Math tutorials were presented as whiteboard presentations using Hitachis Starboard to create the graphics and TechSmiths Camtasia Studio to record the presentations. The CD-ROM is in a web-page format created with Macromedias Dreamweaver. All of these elements are integrated into a single course supplement that can be viewed by any computer with a web browser.

  1. RNA Editing and Its Molecular Mechanism in Plant Organelles

    PubMed Central

    Ichinose, Mizuho; Sugita, Mamoru

    2016-01-01

    RNA editing by cytidine (C) to uridine (U) conversions is widespread in plant mitochondria and chloroplasts. In some plant taxa, “reverse” U-to-C editing also occurs. However, to date, no instance of RNA editing has yet been reported in green algae and the complex thalloid liverworts. RNA editing may have evolved in early land plants 450 million years ago. However, in some plant species, including the liverwort, Marchantia polymorpha, editing may have been lost during evolution. Most RNA editing events can restore the evolutionarily conserved amino acid residues in mRNAs or create translation start and stop codons. Therefore, RNA editing is an essential process to maintain genetic information at the RNA level. Individual RNA editing sites are recognized by plant-specific pentatricopeptide repeat (PPR) proteins that are encoded in the nuclear genome. These PPR proteins are characterized by repeat elements that bind specifically to RNA sequences upstream of target editing sites. In flowering plants, non-PPR proteins also participate in multiple RNA editing events as auxiliary factors. C-to-U editing can be explained by cytidine deamination. The proteins discovered to date are important factors for RNA editing but a bona fide RNA editing enzyme has yet to be identified. PMID:28025543

  2. Digital In, Digital Out: Digital Editing with Firewire.

    ERIC Educational Resources Information Center

    Doyle, Bob; Sauer, Jeff

    1997-01-01

    Reviews linear and nonlinear digital video (DV) editing equipment and software, using the IEEE 1394 (FireWire) connector. Includes a chart listing specifications and rating eight DV editing systems, reviews two DV still-photo cameras, and previews beta DV products. (PEN)

  3. First Season Catfish Farming. A Workbook for Beginning Pond and Cage Culture of Channel Catfish. Teacher Edition and Student Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Board of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This workbook, comprised of both the teacher and student editions, presents guidelines useful for first-year catfish farmers in Oklahoma using pond or cage cultures to raise channel catfish. The teacher edition is a set of unit guidelines only. Contents include a list of suggested readings, important addresses with types of information available…

  4. Government Contract Law (9th Edition)

    DTIC Science & Technology

    1987-04-01

    This Ninth Edition, like its predecessors, will serve as the textbook for the Government Contract Law taught at the School of Systems and Logistics...drawn from Government Contract Law -Cases, 1987 edition, for a rounded approach to the subject. This edition of the text includes coverage of the...Government Contract Law complements the Federal Acquisition Regulation and provides a preventive law treatment for contracting personnel. While it may

  5. ICD-11 and DSM-5 personality trait domains capture categorical personality disorders: Finding a common ground.

    PubMed

    Bach, Bo; Sellbom, Martin; Skjernov, Mathias; Simonsen, Erik

    2018-05-01

    The five personality disorder trait domains in the proposed International Classification of Diseases, 11th edition and the Diagnostic and Statistical Manual of Mental Disorders, 5th edition are comparable in terms of Negative Affectivity, Detachment, Antagonism/Dissociality and Disinhibition. However, the International Classification of Diseases, 11th edition model includes a separate domain of Anankastia, whereas the Diagnostic and Statistical Manual of Mental Disorders, 5th edition model includes an additional domain of Psychoticism. This study examined associations of International Classification of Diseases, 11th edition and Diagnostic and Statistical Manual of Mental Disorders, 5th edition trait domains, simultaneously, with categorical personality disorders. Psychiatric outpatients ( N = 226) were administered the Structured Clinical Interview for DSM-IV Axis II Personality Disorders Interview and the Personality Inventory for DSM-5. International Classification of Diseases, 11th edition and Diagnostic and Statistical Manual of Mental Disorders, 5th edition trait domain scores were obtained using pertinent scoring algorithms for the Personality Inventory for DSM-5. Associations between categorical personality disorders and trait domains were examined using correlation and multiple regression analyses. Both the International Classification of Diseases, 11th edition and the Diagnostic and Statistical Manual of Mental Disorders, 5th edition domain models showed relevant continuity with categorical personality disorders and captured a substantial amount of their information. As expected, the International Classification of Diseases, 11th edition model was superior in capturing obsessive-compulsive personality disorder, whereas the Diagnostic and Statistical Manual of Mental Disorders, 5th edition model was superior in capturing schizotypal personality disorder. These preliminary findings suggest that little information is 'lost' in a transition to trait domain models and potentially adds to narrowing the gap between Diagnostic and Statistical Manual of Mental Disorders, 5th edition and the proposed International Classification of Diseases, 11th edition model. Accordingly, the International Classification of Diseases, 11th edition and Diagnostic and Statistical Manual of Mental Disorders, 5th edition domain models may be used to delineate one another as well as features of familiar categorical personality disorder types. A preliminary category-to-domain 'cross walk' is provided in the article.

  6. Regulatory factors governing adenosine-to-inosine (A-to-I) RNA editing.

    PubMed

    Hong, HuiQi; Lin, Jaymie Siqi; Chen, Leilei

    2015-03-31

    Adenosine-to-inosine (A-to-I) RNA editing, the most prevalent mode of transcript modification in higher eukaryotes, is catalysed by the adenosine deaminases acting on RNA (ADARs). A-to-I editing imposes an additional layer of gene regulation as it dictates various aspects of RNA metabolism, including RNA folding, processing, localization and degradation. Furthermore, editing events in exonic regions contribute to proteome diversity as translational machinery decodes inosine as guanosine. Although it has been demonstrated that dysregulated A-to-I editing contributes to various diseases, the precise regulatory mechanisms governing this critical cellular process have yet to be fully elucidated. However, integration of previous studies revealed that regulation of A-to-I editing is multifaceted, weaving an intricate network of auto- and transregulations, including the involvement of virus-originated factors like adenovirus-associated RNA. Taken together, it is apparent that tipping of any regulatory components will have profound effects on A-to-I editing, which in turn contributes to both normal and aberrant physiological conditions. A complete understanding of this intricate regulatory network may ultimately be translated into new therapeutic strategies against diseases driven by perturbed RNA editing events. Herein, we review the current state of knowledge on the regulatory mechanisms governing A-to-I editing and propose the role of other co-factors that may be involved in this complex regulatory process.

  7. MENTAL DEFICIENCY. SECOND EDITION.

    ERIC Educational Resources Information Center

    HILLIARD, L.T.; KIRMAN, BRIAN H.

    REVISED TO INCLUDE LEGISLATIVE AND ADMINISTRATIVE PROCEDURES NEW IN BRITAIN SINCE THE 1957 EDITION, THE TEXT INCLUDES RECENT ADVANCES IN ETIOLOGY, PATHOLOGY, AND TREATMENT OF MENTAL DEFICIENCY. CONSIDERATION OF THE BACKGROUND OF MENTAL DEFICIENCY INCLUDES HISTORICAL AND LEGAL ASPECTS, THE SOCIAL BACKGROUND OF MENTAL DEFECT, PRENATAL CAUSES OF…

  8. Hvězdářství krále Jana

    NASA Astrophysics Data System (ADS)

    Černá, Alena M.; Hadrava, Petr; Hadravová, Alena; Stluka, Martin

    The critical edition of the collection "King John's Astronomy" is based on the Old Czech manuscript written at the beginning of the 15th century which is preserved at the Library of the National Museum in Prague (ms. II F 14). The collection consists of several separate parts - first of all it contains astronomical and astrological treatises refering to Ptolemy's works. Explanations on the impact of the seven planets and twelve zodiacal signs on the fate of man, who was born under their influence, prevail in the texts. The texts which are connected with Hippocrates and Galenos' doctrines about humoral physiology and humoral pathology are another subject. They are supplemented by a treatise on blood-letting and by pharmaceutical instructions on different weight units. Another treatise deals with God, God's acts and with human fate. The manuscript also contains calendar tools for the calculation of Easter and other feasts during the year. The origin of this Old Czech text coincides with the period of the development of national languages as languages of science. Vocabulary contained in the manuscript is rich. It yields evidence about the formation of terminological systems in various fields involved in the collection. The Old Czech language of this literary monument exhibits unexpectedly archaic features. The present edition is a result of interdisciplinary collaboration of researchers from the fields of diachronic Bohemistics, classical philology, and astronomy. The publication is completed with the critical apparatus, indices, vocabulary, by a list of the chosen literature and other related supplements.

  9. Genome-editing Technologies for Gene and Cell Therapy.

    PubMed

    Maeder, Morgan L; Gersbach, Charles A

    2016-03-01

    Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed.

  10. Genome-editing Technologies for Gene and Cell Therapy

    PubMed Central

    Maeder, Morgan L; Gersbach, Charles A

    2016-01-01

    Gene therapy has historically been defined as the addition of new genes to human cells. However, the recent advent of genome-editing technologies has enabled a new paradigm in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. This includes the correction of mutations that cause disease, the addition of therapeutic genes to specific sites in the genome, and the removal of deleterious genes or genome sequences. This review presents the mechanisms of different genome-editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), meganucleases, and the CRISPR/Cas9 system. We then summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. The current challenges and future prospects for genome editing as a transformative technology for gene and cell therapy are also discussed. PMID:26755333

  11. Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme.

    PubMed

    Vallecillo-Viejo, Isabel C; Liscovitch-Brauer, Noa; Montiel-Gonzalez, Maria Fernanda; Eisenberg, Eli; Rosenthal, Joshua J C

    2018-01-02

    Site-directed RNA editing (SDRE) is a general strategy for making targeted base changes in RNA molecules. Although the approach is relatively new, several groups, including our own, have been working on its development. The basic strategy has been to couple the catalytic domain of an adenosine (A) to inosine (I) RNA editing enzyme to a guide RNA that is used for targeting. Although highly efficient on-target editing has been reported, off-target events have not been rigorously quantified. In this report we target premature termination codons (PTCs) in messages encoding both a fluorescent reporter protein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein transiently transfected into human epithelial cells. We demonstrate that while on-target editing is efficient, off-target editing is extensive, both within the targeted message and across the entire transcriptome of the transfected cells. By redirecting the editing enzymes from the cytoplasm to the nucleus, off-target editing is reduced without compromising the on-target editing efficiency. The addition of the E488Q mutation to the editing enzymes, a common strategy for increasing on-target editing efficiency, causes a tremendous increase in off-target editing. These results underscore the need to reduce promiscuity in current approaches to SDRE.

  12. 36 CFR 1206.22 - What type of proposal is eligible for a publications grant?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... projects include the production of: (1) Documentary editions that involve collecting, compiling... records; (2) Microfilm editions consisting of organized collections of images of original sources, usually without transcription and annotations; (3) Electronic editions consisting of organized collections of...

  13. 36 CFR 1206.22 - What type of proposal is eligible for a publications grant?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... projects include the production of: (1) Documentary editions that involve collecting, compiling... records; (2) Microfilm editions consisting of organized collections of images of original sources, usually without transcription and annotations; (3) Electronic editions consisting of organized collections of...

  14. 36 CFR § 1206.22 - What type of proposal is eligible for a publications grant?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... projects include the production of: (1) Documentary editions that involve collecting, compiling... records; (2) Microfilm editions consisting of organized collections of images of original sources, usually without transcription and annotations; (3) Electronic editions consisting of organized collections of...

  15. Advances in targeted genome editing.

    PubMed

    Perez-Pinera, Pablo; Ousterout, David G; Gersbach, Charles A

    2012-08-01

    New technologies have recently emerged that enable targeted editing of genomes in diverse systems. This includes precise manipulation of gene sequences in their natural chromosomal context and addition of transgenes to specific genomic loci. This progress has been facilitated by advances in engineering targeted nucleases with programmable, site-specific DNA-binding domains, including zinc finger proteins and transcription activator-like effectors (TALEs). Recent improvements have enhanced nuclease performance, accelerated nuclease assembly, and lowered the cost of genome editing. These advances are driving new approaches to many areas of biotechnology, including biopharmaceutical production, agriculture, creation of transgenic organisms and cell lines, and studies of genome structure, regulation, and function. Genome editing is also being investigated in preclinical and clinical gene therapies for many diseases. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Cloud Properties of CERES-MODIS Edition 4 and CERES-VIIRS Edition 1

    NASA Technical Reports Server (NTRS)

    Sun-Mack, Sunny; Minnis, Patrick; Chang, Fu-Lung; Hong, Gang; Arduini, Robert; Chen, Yan; Trepte, Qing; Yost, Chris; Smith, Rita; Brown, Ricky; hide

    2015-01-01

    The Clouds and Earth's Radiant Energy System (CERES) analyzes MODerate-resolution Imaging Spectroradiometer (MODIS) data and Visible Infrared Imaging Radiometer Suite (VIIRS) to derive cloud properties that are combine with aerosol and CERES broadband flux data to create a multi-parameter data set for climate study. CERES has produced over 15 years of data from Terra and over 13 years of data from Aqua using the CERES-MODIS Edition-2 cloud retrieval algorithm. A recently revised algorithm, CERESMODIS Edition 4, has been developed and is now generating enhanced cloud data for climate research (over 10 years for Terra and 8 years for Aqua). New multispectral retrievals of properties are included along with a multilayer cloud retrieval system. Cloud microphysical properties are reported at 3 wavelengths, 0.65, 1.24, and 2.1 microns to enable better estimates of the vertical profiles of cloud water contents. Cloud properties over snow are retrieved using the 1.24-micron channel. A new CERES-VIIRS cloud retrieval package was developed for the VIIRS spectral complement and is currently producing the CERES-VIIRS Edition 1 cloud dataset. The results from CERES-MODIS Edition 4 and CERES-VIIRS Edition 1 are presented and compared with each other and other datasets, including CALIPSO, CloudSat and the CERES-MODIS Edition-2 results.

  17. Countermeasures That Work : A Highway Safety Countermeasure Guide For State Highway Safety Offices Sixth Edition, 2011

    DOT National Transportation Integrated Search

    2011-02-01

    This edition of Countermeasures that Work was prepared by the University of North Carolina Highway Safety Research Center (HSRC). Researchers who contributed to this edition include Arthur H. Goodwin, Libby J. Thomas, William L. Hall, and Mary Ellen ...

  18. Diesel Technology: Workplace Skills. Teacher Edition and Student Edition.

    ERIC Educational Resources Information Center

    Kellum, Mary

    This publication consists of instructional materials to provide secondary and postsecondary students with skills useful in pursuing a career in the diesel industry. Introductory materials in the teacher edition include information on use of the publication, competency profile, instructional/task analysis, related academic and workplace skills…

  19. 45 CFR 73.735-705 - Writing and editing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... different wording is approved by the Assistant General Counsel, Business and Administrative Law Division... duties; (This includes editing for scientific or professional journals which is related to his or her official duties.) (3) Material is written or edited which pertains to any Government-sponsored research or...

  20. Translational Control in Bone Marrow Failure

    DTIC Science & Technology

    2016-07-01

    been made in using new tools to model granulopoiesis, including generation of patient-derived iPSC and CRISPR -Cas9 genome-editing technology to...in cell lines in patient-derived iPSC gene models, including using CRISPR genome editing, as overall described in Tidwell et al. 2014 and Nayak et...proxy for neutropenia in this cellular model system. 3h. Use patient-derived iPSC models and CRISPR /Cas9 genome-editing to generate a range of ELANE

  1. Global analysis of A-to-I RNA editing reveals association with common disease variants

    PubMed Central

    Jain, Rajeev; Jain, Anamika; Betsholtz, Christer; Giannarelli, Chiara; Kovacic, Jason C.; Ruusalepp, Arno; Skogsberg, Josefin; Hao, Ke; Schadt, Eric E.

    2018-01-01

    RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated with RNA editing; one that influences type 2 diabetes (rs2028299) was associated with editing in ARPIN. Twenty-five genes, including LRP11 and PLIN5, had editing sites that were associated with plasma lipid levels. Our findings provide new insights into the genetic regulation of RNA editing and establish a rich catalogue for further exploration of this process. PMID:29527417

  2. 2015 Edition Health Information Technology (Health IT) Certification Criteria, 2015 Edition Base Electronic Health Record (EHR) Definition, and ONC Health IT Certification Program Modifications. Final rule.

    PubMed

    2015-10-16

    This final rule finalizes a new edition of certification criteria (the 2015 Edition health IT certification criteria or "2015 Edition'') and a new 2015 Edition Base Electronic Health Record (EHR) definition, while also modifying the ONC Health IT Certification Program to make it open and accessible to more types of health IT and health IT that supports various care and practice settings. The 2015 Edition establishes the capabilities and specifies the related standards and implementation specifications that Certified Electronic Health Record Technology (CEHRT) would need to include to, at a minimum, support the achievement of meaningful use by eligible professionals (EPs), eligible hospitals, and critical access hospitals (CAHs) under the Medicare and Medicaid EHR Incentive Programs (EHR Incentive Programs) when such edition is required for use under these programs.

  3. Annual Editions: Early Childhood Education 06/07

    ERIC Educational Resources Information Center

    Paciorek, Karen Menke, Ed.

    2006-01-01

    This 27th edition of "Annual Editions: Early Childhood Education" provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for…

  4. Transportation-markings database : international marine aids to navigation. Volume 1, parts C and D

    DOT National Transportation Integrated Search

    1988-01-01

    This monograph is the second edition of Volume I, Parts C and D of what was formerly termed Transportation Markings: A Study in Communication. The first edition of Volume I also included Parts A and B. The original edition was published by University...

  5. 100 Years of Mass Deworming Programmes: A Policy Perspective From the World Bank's Disease Control Priorities Analyses.

    PubMed

    Bundy, Donald A P; Appleby, Laura J; Bradley, Mark; Croke, Kevin; Hollingsworth, T Deirdre; Pullan, Rachel; Turner, Hugo C; de Silva, Nilanthi

    2018-01-01

    For more than 100 years, countries have used mass drug administration as a public health response to soil-transmitted helminth infection. The series of analyses published as Disease Control Priorities is the World Bank's vehicle for exploring the cost-effectiveness and value for money of public health interventions. The first edition was published in 1993 as a technical supplement to the World Bank's World Development Report Investing in Health where deworming was used as an illustrative example of value for money in treating diseases with relatively low morbidity but high prevalence. Over the second (2006) and now third (2017) editions deworming has been an increasingly persuasive example to use for this argument. The latest analyses recognize the negative impact of intestinal worm infection on human capital in poor communities and document a continuing decline in worm infection as a result of the combination of high levels of mass treatment and ongoing economic development trends in poor communities. © 2018 Elsevier Ltd All rights reserved.

  6. Linnaeus' restless system: translation as textual engineering in eighteenth-century botany.

    PubMed

    Dietz, Bettina

    2016-04-01

    In this essay, translations of Linnaeus' Systema naturae into various European languages will be placed into the context of successively expanded editions of Linnaeus' writings. The ambition and intention of most translators was not only to make the Systema naturae accessible for practical botanical use by a wider readership, but also to supplement and correct it, and thus to shape it. By recruiting more users, translations made a significant contribution to keeping the Systema up to date and thus maintaining its practical value for decades. The need to incorporate countless additions and corrections into an existing text, to document their provenance, to identify inconsistencies, and to refer to relevant observations, descriptions, and illustrations in the botanical literature all helped to develop and refine techniques of textual montage. This form of textual engineering, becoming increasingly complex with each translation cycle, shaped the external appearance of new editions of the Systema, and reflected the modular architecture of a botanical system designed for expansion.

  7. Efficient genome engineering of a virulent Klebsiella bacteriophage using CRISPR-Cas9.

    PubMed

    Shen, Juntao; Zhou, Jinjie; Chen, Guo-Qiang; Xiu, Zhi-Long

    2018-06-13

    Klebsiella pneumoniae is one of the most common nosocomial opportunistic pathogens usually with multiple drug-resistance. Phage therapy, a potential new therapeutics to replace or supplement antibiotics, has attracted much attention. However, very few Klebsiella phages have been well-characterized as the lack of efficient genome editing tools. Here, Cas9 from Streptococcus pyogenes and a single guide RNA (sgRNA) were used to modify a virulent Klebsiella bacteriophage phiKpS2. We firstly evaluated the distribution of sgRNA activity in phages and proved that it's largely inconsistent with the predicted activity from current models trained on eukaryotic cell datasets. A simple CRISPR-based phage genome editing procedure was developed based on the discovery that homologous arms as short as 30-60 bp was sufficient to introduce point mutation, gene deletion and swap. We also demonstrated that weak sgRNAs could be used for precise phage genome editing but failed to select random recombinants, possibly because inefficient cleavage can be tolerated through continuous repair by homologous recombination with the uncut genomes. Small frameshift deletion was proved to be an efficient way to evaluate the essentiality of phage genes. By using the above strategies, a putative promoter and nine genes of phiKpS2 were successfully deleted. Interestingly, the holin gene can be deleted with little effect on phiKpS2 infection, but the reason is not yet clear. This study established an efficient, time-saving, and cost-effective procedure for phage genome editing, which is expected to significantly promote the development of bacteriophage therapy. IMPORTANCE In the present study, we have addressed an efficient, time-saving and cost-effective CRISPR-based phage genome editing of Klebsiella phage, which has the potential to significantly expand our knowledge of phage-host interactions and to promote the applications of phage therapy. The distribution of sgRNA activity was first evaluated in phages. Short homologous arms were proved enough to introduce point mutation, small frameshift deletion, gene deletion and swap into phages, and weak sgRNAs were proved useful for precise phage genome editing but failed to select random recombinants, which all make the CRISPR-based phage genome editing easier to use. Copyright © 2018 American Society for Microbiology.

  8. Test-retest reliability and sensitivity to change of the dimensional anxiety scales for DSM-5.

    PubMed

    Knappe, Susanne; Klotsche, Jens; Heyde, Franziska; Hiob, Sarah; Siegert, Jens; Hoyer, Jürgen; Strobel, Anja; LeBeau, Richard T; Craske, Michelle G; Wittchen, Hans-Ulrich; Beesdo-Baum, Katja

    2014-06-01

    This article reports on the test-retest reliability and sensitivity to change of a set of brief dimensional self-rating questionnaires for social anxiety disorder (SAD-D), specific phobia (SP-D), agoraphobia (AG-D), panic disorder (PD-D), and generalized anxiety disorder (GAD-D), as well as a general cross-cutting anxiety scale (Cross-D), which were developed to supplement categorical diagnoses in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). The German versions of the dimensional anxiety scales were administered to 218 students followed up approximately 2 weeks later (Study 1) and 55 outpatients (23 with anxiety diagnoses) followed-up 1 year later (Study 2). Probable diagnostic status in students was determined by the DIA-X/M-CIDI stem screening-questionnaire (SSQ). In the clinical sample, Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) diagnoses were assessed at Time 1 using the DIA-X/M-CIDI. At Time 2, the patient-version of the Clinical Global Impression-Improvement scale (CGI-I) was applied to assess change. Good psychometric properties, including high test-retest reliability, were found for the dimensional scales except for SP-D. In outpatients, improvement at Time 2 was associated with significant decrease in PD-D, GAD-D, and Cross-D scores. Discussion Major advantages of the scales include that they are brief, concise, and based on a consistent template to measure the cognitive, physiological, and behavioral symptoms of fear and anxiety. Further replication in larger samples is needed. Given its modest psychometric properties, SP-D needs refinement. Increasing evidence from diverse samples suggests clinical utility of the dimensional anxiety scales.

  9. The universe, life, and intelligence (Sixth enlarged edition)

    NASA Astrophysics Data System (ADS)

    Shklovskii, Iosif Samuilovich

    This classic work examines the possibility of the existence of life (including intelligent life) on other planetary systems. This enlarged edition includes essays on the search for extraterrestrial civilizations and the possibility of communication with intelligent beings on other planets.

  10. Data-Base Software For Tracking Technological Developments

    NASA Technical Reports Server (NTRS)

    Aliberti, James A.; Wright, Simon; Monteith, Steve K.

    1996-01-01

    Technology Tracking System (TechTracS) computer program developed for use in storing and retrieving information on technology and related patent information developed under auspices of NASA Headquarters and NASA's field centers. Contents of data base include multiple scanned still images and quick-time movies as well as text. TechTracS includes word-processing, report-editing, chart-and-graph-editing, and search-editing subprograms. Extensive keyword searching capabilities enable rapid location of technologies, innovators, and companies. System performs routine functions automatically and serves multiple users.

  11. Book review: Extreme ocean waves

    USGS Publications Warehouse

    Geist, Eric L.

    2017-01-01

    “Extreme Ocean Waves”, edited by E. Pelinovsky and C. Kharif, second edition, Springer International Publishing, 2016; ISBN: 978-3-319-21574-7, ISBN (eBook): 978-3-319-21575-4The second edition of “Extreme Ocean Waves” published by Springer is an update of a collection of 12 papers edited by Efim Pelinovsky and Christian Kharif following the April 2007 meeting of the General Assembly of the European Geosciences Union. In this edition, three new papers have been added and three more have been substantially revised. Color figures are now included, which greatly aids in reading several of the papers, and is especially helpful in visualizing graphs as in the paper on symbolic computation of nonlinear wave resonance (Tobisch et al.). A note on terminology: extreme waves in this volume broadly encompass different types of waves, including deep-water and shallow-water rogue waves (which are alternatively termed freak waves), and internal waves. One new paper on tsunamis (Viroulet et al.) is now included in the second edition of this volume. Throughout the book, the reader will find a combination of laboratory, theoretical, and statistical/empirical treatment necessary for the complete examination of this subject. In the Introduction, the editors underscore the importance of studying extreme waves, documenting a dramatic instance of damaging extreme waves that recently occurred in 2014.

  12. [Genome-editing: focus on the off-target effects].

    PubMed

    He, Xiubin; Gu, Feng

    2017-10-25

    Breakthroughs of genome-editing in recent years have paved the way to develop new therapeutic strategies. These genome-editing tools mainly include Zinc-finger nucleases (ZFNs), Transcription activator-like effector nucleases (TALENs), and clustered regulatory interspaced short palindromic repeat (CRISPR)/Cas-based RNA-guided DNA endonucleases. However, off-target effects are still the major issue in genome editing, and limit the application in gene therapy. Here, we summarized the cause and compared different detection methods of off-targets.

  13. Professional Issues in Therapeutic Recreation: On Competence and Outcomes. 2nd Edition

    ERIC Educational Resources Information Center

    Stumbo, Norma J., Ed.

    2009-01-01

    The second edition of "Professional Issues in Therapeutic Recreation: On Competence and Outcomes" is greatly expanded to include a wider variety of introductory materials and updates on current professional issues. The second edition represents a timely review of the state of affairs in the profession of therapeutic recreation. This book contains…

  14. The Kamusi Project Edit Engine: A Tool for Collaborative Lexicography.

    ERIC Educational Resources Information Center

    Benjamin, Martin; Biersteker, Ann

    2001-01-01

    Discusses the design and implementation of the Kamusi Project Edit Engine, a Web-based software system uniquely suited to the needs of Swahili collaborative lexicography. Describes the edit engine, including organization of the lexicon and the mechanics by which participants use the system, discusses philosophical issues confronted in the design,…

  15. Canadian Counsellor. Special Edition on Employment Counselling = Conseiller Canadien. Edition Speciale sur le Counselling d'Emploi.

    ERIC Educational Resources Information Center

    Paquin, Andre, Ed.

    1980-01-01

    This special edition on employment counseling contains a series of articles demonstrating some of the employment counseling initiatives currently underway in Canada. Included are separate English and French texts of each of the following articles: "The Assessment Component of Employment Counselling: Some Suggestions," by P. J. Patsula…

  16. Commercial and Industrial Wiring. Teacher Edition [and] Student Edition. Third Edition.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; Flowers, Gary; Aneke, Norbert O.

    This revised curriculum guide for teachers and students includes the additional technical knowledge and applications required to help prepare students for job entry in the commercial and industrial wiring trade. The curriculum guide contains 16 units that cover the following topics: (1) blueprint reading and load calculations; (2) tools and…

  17. Financing Education in a Climate of Change. Eighth Edition.

    ERIC Educational Resources Information Center

    Brimley, Vern, Jr.; Garfield, Rulon R.

    Since the publication of the seventh edition of this textbook in 1999, there have been many new developments in the education finance arena. Those changes are discussed in this eighth edition. Additional new material includes Internet resources, new exercises for further "laboratory" work, updated figures and tables, and fresh information on court…

  18. Civil Technology Applications. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Schertz, Karen

    Teacher and student editions of Civil Technology Applications are one in a series of competency-based instructional materials for drafting and civil technology programs. It includes the technical content and tasks necessary for a student to be employed as a drafter or civil technician in a civil engineering firm. Introductory pages in the teacher…

  19. Shielded Metal Arc Pipe Welding. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Fortney, Clarence; And Others

    This second edition of the shielded metal arc pipe welding curriculum guide presents both basic and advanced pipe welding skills. All specifications for procedure and welder qualification are presented according to national standards. The standards also include the test position for both groove and fillet pipe welding. The guide contains three…

  20. Iodine intake in human nutrition: a systematic literature review

    PubMed Central

    Gunnarsdottir, Ingibjörg; Dahl, Lisbeth

    2012-01-01

    The present literature review is a part of the NNR5 project with the aim of reviewing and updating the scientific basis of the 4th edition of the Nordic Nutrition Recommendations (NNR) issued in 2004. The main objective of the review is to assess the influence of different intakes of iodine at different life stages (infants, children, adolescents, adults, elderly, and during pregnancy and lactation) in order to estimate the requirement for adequate growth, development, and maintenance of health. The literature search resulted in 1,504 abstracts. Out of those, 168 papers were identified as potentially relevant. Full paper selection resulted in 40 papers that were quality assessed (A, B, or C). The grade of evidence was classified as convincing, probable, suggestive, and no conclusion. We found suggestive evidence for improved maternal iodine status and thyroid function by iodine supplementation during pregnancy. Suggestive evidence was found for the relationship between improved thyroid function (used as an indicator of iodine status) during pregnancy and cognitive function in the offspring up to 18 months of age. Moderately to severely iodine-deficient children will probably benefit from iodine supplementation or improved iodine status in order to improve their cognitive function, while only one study showed improved cognitive function following iodine supplementation in children from a mildly iodine-deficient area (no conclusion). No conclusions can be drawn related to other outcomes included in our review. There are no new data supporting changes in dietary reference values for children or adults. The rationale for increasing the dietary reference values for pregnant and lactating women in the NNR5 needs to be discussed in a broader perspective, taking iodine status of pregnant women in the Nordic countries into account. PMID:23060737

  1. Investigating Variation, Teacher's Edition. Probing the Natural World/3.

    ERIC Educational Resources Information Center

    Florida State Univ., Tallahassee. Dept. of Science Education.

    The teacher's edition for the unit entitled "Investigating Variation" in Intermediate Science Curriculum Study Level III, provides numerous suggestions for teaching specific activities included in the unit. The unit is aimed at selected aspects of measurement and analysis. The chapters included are "The Road…

  2. Identification of two pentatricopeptide repeat genes required for RNA editing and zinc binding by C-terminal cytidine deaminase-like domains.

    PubMed

    Hayes, Michael L; Giang, Karolyn; Berhane, Beniam; Mulligan, R Michael

    2013-12-20

    Many transcripts expressed from plant organelle genomes are modified by C-to-U RNA editing. Nuclear encoded pentatricopeptide repeat (PPR) proteins are required as RNA binding specificity determinants in the RNA editing mechanism. Bioinformatic analysis has shown that most of the Arabidopsis PPR proteins necessary for RNA editing events include a C-terminal portion that shares structural characteristics with a superfamily of deaminases. The DYW deaminase domain includes a highly conserved zinc binding motif that shares characteristics with cytidine deaminases. The Arabidopsis PPR genes, ELI1 and DOT4, both have DYW deaminase domains and are required for single RNA editing events in chloroplasts. The ELI1 DYW deaminase domain was expressed as a recombinant protein in Escherichia coli and was shown to bind two zinc atoms per polypeptide. Thus, the DYW deaminase domain binds a zinc metal ion, as expected for a cytidine deaminase, and is potentially the catalytic component of an editing complex. Genetic complementation experiments demonstrate that large portions of the DYW deaminase domain of ELI1 may be eliminated, but the truncated genes retain the ability to restore editing site conversion in a mutant plant. These results suggest that the catalytic activity can be supplied in trans by uncharacterized protein(s) of the editosome.

  3. Plastid Transcript Editing across Dinoflagellate Lineages Shows Lineage-Specific Application but Conserved Trends

    PubMed Central

    Klinger, Christen M; Paoli, Lucas; Newby, Robert J; Wang, Matthew Yu-Wei; Carroll, Hyrum D; Leblond, Jeffrey D; Howe, Christopher J; Dacks, Joel B; Bowler, Chris; Cahoon, Aubery Bruce; Dorrell, Richard G

    2018-01-01

    Abstract Dinoflagellates are a group of unicellular protists with immense ecological and evolutionary significance and cell biological diversity. Of the photosynthetic dinoflagellates, the majority possess a plastid containing the pigment peridinin, whereas some lineages have replaced this plastid by serial endosymbiosis with plastids of distinct evolutionary affiliations, including a fucoxanthin pigment-containing plastid of haptophyte origin. Previous studies have described the presence of widespread substitutional RNA editing in peridinin and fucoxanthin plastid genes. Because reports of this process have been limited to manual assessment of individual lineages, global trends concerning this RNA editing and its effect on the biological function of the plastid are largely unknown. Using novel bioinformatic methods, we examine the dynamics and evolution of RNA editing over a large multispecies data set of dinoflagellates, including novel sequence data from the peridinin dinoflagellate Pyrocystis lunula and the fucoxanthin dinoflagellate Karenia mikimotoi. We demonstrate that while most individual RNA editing events in dinoflagellate plastids are restricted to single species, global patterns, and functional consequences of editing are broadly conserved. We find that editing is biased toward specific codon positions and regions of genes, and generally corrects otherwise deleterious changes in the genome prior to translation, though this effect is more prevalent in peridinin than fucoxanthin lineages. Our results support a model for promiscuous editing application subsequently shaped by purifying selection, and suggest the presence of an underlying editing mechanism transferred from the peridinin-containing ancestor into fucoxanthin plastids postendosymbiosis, with remarkably conserved functional consequences in the new lineage. PMID:29617800

  4. Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage

    PubMed Central

    Cattenoz, Pierre B.; Taft, Ryan J.; Westhof, Eric; Mattick, John S.

    2013-01-01

    Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated. Indeed, a number of genome-wide analyses have shown that A > I editing is not limited to a few mRNAs, as originally thought, but occurs widely across the transcriptome, especially in the brain. Importantly, there is increasing evidence that A > I editing is essential for animal development and nervous system function. To more efficiently characterize the complete catalog of ADAR events in the mammalian transcriptome we developed a high-throughput protocol to identify A > I editing sites, which exploits the capacity of glyoxal to protect guanosine, but not inosine, from RNAse T1 treatment, thus facilitating extraction of RNA fragments with inosine bases at their termini for high-throughput sequencing. Using this method we identified 665 editing sites in mouse brain RNA, including most known sites and suite of novel sites that include nonsynonymous changes to protein-coding genes, hyperediting of genes known to regulate p53, and alterations to non-protein-coding RNAs. This method is applicable to any biological system for the de novo discovery of A > I editing sites, and avoids the complicated informatic and practical issues associated with editing site identification using traditional RNA sequencing data. This approach has the potential to substantially increase our understanding of the extent and function of RNA editing, and thereby to shed light on the role of transcriptional plasticity in evolution, development, and cognition. PMID:23264566

  5. Therapeutic Genome Editing and its Potential Enhancement through CRISPR Guide RNA and Cas9 Modifications.

    PubMed

    Batzir, Nurit Assia; Tovin, Adi; Hendel, Ayal

    2017-06-01

    Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. The genome editing process relies on creating a site-specific DNA double-strand break (DSB) by engineered nucleases and then allowing the cell's repair machinery to repair the break such that precise changes are made to the DNA sequence. The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing accelerates the progress towards using genome editing as a new approach to human therapeutics. Here we review how genome editing using engineered nucleases works and how using different genome editing outcomes can be used as a tool set for treating human diseases. We then review the major challenges of therapeutic genome editing and we discuss how its potential enhancement through CRISPR guide RNA and Cas9 protein modifications could resolve some of these challenges. Copyright© of YS Medical Media ltd.

  6. Changing genetic information through RNA editing

    NASA Technical Reports Server (NTRS)

    Maas, S.; Rich, A.

    2000-01-01

    RNA editing, the post-transcriptional alteration of a gene-encoded sequence, is a widespread phenomenon in eukaryotes. As a consequence of RNA editing, functionally distinct proteins can be produced from a single gene. The molecular mechanisms involved include single or multiple base insertions or deletions as well as base substitutions. In mammals, one type of substitutional RNA editing, characterized by site-specific base-modification, was shown to modulate important physiological processes. The underlying reaction mechanism of substitutional RNA editing involves hydrolytic deamination of cytosine or adenosine bases to uracil or inosine, respectively. Protein factors have been characterized that are able to induce RNA editing in vitro. A supergene family of RNA-dependent deaminases has emerged with the recent addition of adenosine deaminases specific for tRNA. Here we review the developments that have substantially increased our understanding of base-modification RNA editing over the past few years, with an emphasis on mechanistic differences, evolutionary aspects and the first insights into the regulation of editing activity.

  7. 'For the benefit of the people': the Dutch translation of the Fasciculus medicinae, Antwerp 1512.

    PubMed

    Coppens, Christian

    2009-01-01

    The article deals with the Dutch translation of the Fasciculus medicinae based on the Latin edition, Venice 1495, with the famous woodcuts created in 1494 for the Italian translation of the original Latin edition of 1491. The woodcuts are compared with the Venetian model. New features in the Antwerp edition include the Skeleton and the Zodiac Man, bot originally based on German models. The text also deals with other woodcuts in the Low Countries based on these Venetian illustrations. The Appendices provide a short title catalog of all the editions and translations based on the Venetian edition and a stemma.

  8. APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

    PubMed Central

    Sharma, Shraddha; Patnaik, Santosh K.; Thomas Taggart, R.; Kannisto, Eric D.; Enriquez, Sally M.; Gollnick, Paul; Baysal, Bora E.

    2015-01-01

    The extent, regulation and enzymatic basis of RNA editing by cytidine deamination are incompletely understood. Here we show that transcripts of hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. This editing alters the amino acid sequences for scores of proteins, including many that are involved in pathogenesis of viral diseases. APOBEC3A, which is known to deaminate cytidines of single-stranded DNA and to inhibit viruses and retrotransposons, mediates this RNA editing. Amino acid residues of APOBEC3A that are known to be required for its DNA deamination and anti-retrotransposition activities were also found to affect its RNA deamination activity. Our study demonstrates the cellular RNA editing activity of a member of the APOBEC3 family of innate restriction factors and expands the understanding of C>U RNA editing in mammals. PMID:25898173

  9. Non-viral delivery of genome-editing nucleases for gene therapy.

    PubMed

    Wang, M; Glass, Z A; Xu, Q

    2017-03-01

    Manipulating the genetic makeup of mammalian cells using programmable nuclease-based genome-editing technology has recently evolved into a powerful avenue that holds great potential for treating genetic disorders. There are four types of genome-editing nucleases, including meganucleases, zinc finger nucleases, transcription activator-like effector nucleases and clustered, regularly interspaced, short palindromic repeat-associated nucleases such as Cas9. These nucleases have been harnessed to introduce precise and specific changes of the genome sequence at virtually any genome locus of interest. The therapeutic relevance of these genome-editing technologies, however, is challenged by the safe and efficient delivery of nuclease into targeted cells. Herein, we summarize recent advances that have been made on non-viral delivery of genome-editing nucleases. In particular, we focus on non-viral delivery of Cas9/sgRNA ribonucleoproteins for genome editing. In addition, the future direction for developing non-viral delivery of programmable nucleases for genome editing is discussed.

  10. Quantifying Genome Editing Outcomes at Endogenous Loci using SMRT Sequencing

    PubMed Central

    Clark, Joseph; Punjya, Niraj; Sebastiano, Vittorio; Bao, Gang; Porteus, Matthew H

    2014-01-01

    SUMMARY Targeted genome editing with engineered nucleases has transformed the ability to introduce precise sequence modifications at almost any site within the genome. A major obstacle to probing the efficiency and consequences of genome editing is that no existing method enables the frequency of different editing events to be simultaneously measured across a cell population at any endogenous genomic locus. We have developed a novel method for quantifying individual genome editing outcomes at any site of interest using single molecule real time (SMRT) DNA sequencing. We show that this approach can be applied at various loci, using multiple engineered nuclease platforms including TALENs, RNA guided endonucleases (CRISPR/Cas9), and ZFNs, and in different cell lines to identify conditions and strategies in which the desired engineering outcome has occurred. This approach facilitates the evaluation of new gene editing technologies and permits sensitive quantification of editing outcomes in almost every experimental system used. PMID:24685129

  11. Introduction to Library Public Services. Sixth Edition. Library and Information Science Text Series.

    ERIC Educational Resources Information Center

    Evans, G. Edward; Amodeo, Anthony J.; Carter, Thomas L.

    This book covers the role, purpose, and philosophy related to each of the major functional areas of library public service. This sixth edition, on the presumption that most people know the basic facts about computer hardware, does not include the chapter (in the previous edition) on computer basics, and instead integrated specific technological…

  12. Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

    USDA-ARS?s Scientific Manuscript database

    Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the domestic pig is a proven model of human physiology and an agriculturally important species. In this study, we utilized the CRISPR/Cas9 system to edit the NANOS2 gene in p...

  13. The Role of Unions in the American Economy. Second Edition.

    ERIC Educational Resources Information Center

    Marshall, Ray; Rungeling, Brian

    Intended as a resource for secondary teachers, this book analyzes the role of unions in the American economy and examines the main forces influencing unions in the United States. This second edition includes important domestic and external events that have affected U.S. economic policy and unions since the first edition was published in 1976.…

  14. Preventing Prejudice: A Guide for Counselors, Educators, and Parents, Second Edition

    ERIC Educational Resources Information Center

    Ponterotto, Joseph G.; Utsey, Shawn O.; Pedersen, Paul B.

    2006-01-01

    This second edition has been completely revised and expanded to provide the most up-to-date and extensive coverage of prejudice and racism available. The new edition of this bestselling text presents a comprehensive overview of these topics and also includes practical tools for combating prejudice development in children, adolescents, and adults.…

  15. Designing Successful Transitions: A Guide for Orienting Students to College. 3rd Edition. The First-Year Experience Monograph Series No. 13

    ERIC Educational Resources Information Center

    Ward-Roof, Jeanine A., Ed.

    2010-01-01

    The 2010 edition of this monograph addresses many topics (e.g., administration of orientation programs, family involvement, student characteristics and needs, assessment, and orientation for specific student populations and institutional types) that were included in previous editions but approaches them with new information, updated data, and…

  16. Rethinking Our Classrooms: Teaching for Equity and Justice. Volume 1. New Edition--Revised and Expanded

    ERIC Educational Resources Information Center

    Au, Wayne, Ed.; Bigelow, Bill, Ed.; Karp, Stan, Ed.

    2007-01-01

    Since the first edition was published in 1994, Rethinking Our Classrooms has sold over 180,000 copies. This revised and expanded edition includes new essays on: (1) science and environmental education; (2) immigration and language; (3) military recruitment; (4) teaching about the world through mathematics; and (5) gay and lesbian issues. Creative…

  17. Foundations of Psychological Testing: A Practical Approach. Second Edition

    ERIC Educational Resources Information Center

    McIntire, Sandra A.; Miller, Leslie A.

    2006-01-01

    The second edition of "Foundations of Psychological Testing: A Practical Approach" is a text for undergraduate students new to the field of psychological testing. Using a conversational format, the authors aim to prepare students to be informed consumers as test users or test takers. Features new to the second edition include: (1) New Content; (2)…

  18. Learning Disabilities and Juvenile Justice. Special Edition. Revised Edition.

    ERIC Educational Resources Information Center

    Tyner, Polly, Ed.

    1995-01-01

    This special newsletter issue on learning disabilities and juvenile justice includes statistics indicating unfavorable outcomes for many individuals with learning disabilities, presents findings of the Incarcerated Youth Task Force Report, and describes five successful programs for teaching reading. Articles include: "Parents Don't Care!--Or Do…

  19. The Community College Story. Third Edition

    ERIC Educational Resources Information Center

    Vaughan, George B.

    2006-01-01

    This concise history of community colleges touches on major themes, including open access and equity, comprehensiveness, community-based philosophy, commitment to teaching, and lifelong learning. The third edition includes revised text as well as updated statistical information, time line, reading list, and Internet resources. In the more than a…

  20. ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain

    PubMed Central

    Vesely, Cornelia; Tauber, Stefanie; Sedlazeck, Fritz J.; Tajaddod, Mansoureh; von Haeseler, Arndt; Jantsch, Michael F.

    2014-01-01

    Adenosine deaminases that act on RNA (ADARs) deaminate adenosines to inosines in double-stranded RNAs including miRNA precursors. A to I editing is widespread and required for normal life. By comparing deep sequencing data of brain miRNAs from wild-type and ADAR2 deficient mouse strains, we detect editing sites and altered miRNA processing at high sensitivity. We detect 48 novel editing events in miRNAs. Some editing events reach frequencies of up to 80%. About half of all editing events depend on ADAR2 while some miRNAs are preferentially edited by ADAR1. Sixty-four percent of all editing events are located within the seed region of mature miRNAs. For the highly edited miR-3099, we experimentally prove retargeting of the edited miRNA to novel 3′ UTRs. We show further that an abundant editing event in miR-497 promotes processing by Drosha of the corresponding pri-miRNA. We also detect reproducible changes in the abundance of specific miRNAs in ADAR2-deficient mice that occur independent of adjacent A to I editing events. This indicates that ADAR2 binding but not editing of miRNA precursors may influence their processing. Correlating with changes in miRNA abundance we find misregulation of putative targets of these miRNAs in the presence or absence of ADAR2. PMID:25260591

  1. Special-effect edit detection using VideoTrails: a comparison with existing techniques

    NASA Astrophysics Data System (ADS)

    Kobla, Vikrant; DeMenthon, Daniel; Doermann, David S.

    1998-12-01

    Video segmentation plays an integral role in many multimedia applications, such as digital libraries, content management systems, and various other video browsing, indexing, and retrieval systems. Many algorithms for segmentation of video have appeared within the past few years. Most of these algorithms perform well on cuts, but yield poor performance on gradual transitions or special effects edits. A complete video segmentation system must also achieve good performance on special effect edit detection. In this paper, we discuss the performance of our Video Trails-based algorithms, with other existing special effect edit-detection algorithms within the literature. Results from experiments testing for the ability to detect edits from TV programs, ranging from commercials to news magazine programs, including diverse special effect edits, which we have introduced.

  2. Quantifying on- and off-target genome editing.

    PubMed

    Hendel, Ayal; Fine, Eli J; Bao, Gang; Porteus, Matthew H

    2015-02-01

    Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. While the ability to make precise and controlled changes at specified sites throughout the genome has grown tremendously in recent years, we still lack a comprehensive and standardized battery of assays for measuring the different genome editing outcomes created at endogenous genomic loci. Here we review the existing assays for quantifying on- and off-target genome editing and describe their utility in advancing the technology. We also highlight unmet assay needs for quantifying on- and off-target genome editing outcomes and discuss their importance for the genome editing field. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. The ethics of creating genetically modified children using genome editing.

    PubMed

    Ishii, Tetsuya

    2017-12-01

    To review the recent ethical, legal, and social issues surrounding human reproduction involving germline genome editing. Genome editing techniques, such as CRISPR/Cas9, have facilitated genetic modification in human embryos. The most likely purpose of germline genome editing is the prevention of serious genetic disease in offspring. However, complex issues still remain, including irremediable risks to fetuses and future generations, the role of women, the availability of alternatives, long-term follow-up, health insurance coverage, misuse for human enhancement, and the potential effects on adoption. Further discussions, a broad consensus, and appropriate regulations are required before human germline genome editing is introduced into the global society. Before germline genome editing is used for disease prevention, a broad consensus must be formed by carefully discussing its ethical, legal, and social issues.

  4. Beyond Word Processing.

    ERIC Educational Resources Information Center

    Haight, Larry

    1989-01-01

    Types of specialty software that can help in computer editing are discussed, including programs for file transformation, optical character recognition, facsimile transmission, spell-checking, style assistance, editing, indexing, and headline-writing. (MSE)

  5. Idaho Library Laws, 1996-1997. Full Edition.

    ERIC Educational Resources Information Center

    Idaho State Library, Boise.

    This new edition of the "Idaho Library Laws" contains changes through the 1996 legislative session and includes "Idaho Code" sections that legally affect city, school-community or district libraries, or the Idaho State Library. These sections include the basic library laws in "Idaho Code" Title 33, Chapters 25, 26,…

  6. Introduction to Approaches in Music Therapy. Second Edition

    ERIC Educational Resources Information Center

    Darrow, Alice Ann, Ed.

    2008-01-01

    The second edition of "Introduction to Approaches in Music Therapy" includes a new introductory chapter that addresses historical perspectives on the approaches, a rationale for the categorization of approaches, and discussion on professional issues related to the use of these approaches. Each of the chapters addressing approaches includes updated…

  7. Surgical Techniques. Second Edition. Teacher Edition.

    ERIC Educational Resources Information Center

    Bushey, Vicki; And Others

    This instructor's manual contains 18 units of instruction for a course on surgical technology designed to include the entry-level competencies students need as a surgical technologist. Each unit includes some or all of the following basic components of a unit of instruction: objective sheet, suggested activities for the teacher, assignment sheets…

  8. Advanced Digital Imaging Laboratory Using MATLAB® (Second edition)

    NASA Astrophysics Data System (ADS)

    Yaroslavsky, Leonid P.

    2016-09-01

    The first edition of this text book focussed on providing practical hands-on experience in digital imaging techniques for graduate students and practitioners keeping to a minimum any detailed discussion on the underlying theory. In this new extended edition, the author builds on the strength of the original edition by expanding the coverage to include formulation of the major theoretical results that underlie the exercises as well as introducing numerous modern concepts and new techniques. Whether you are studying or already using digital imaging techniques, developing proficiency in the subject is not possible without mastering practical skills. Including more than 100 MATLAB® exercises, this book delivers a complete applied course in digital imaging theory and practice. Part of IOP Series in Imaging Engineering Supplementary MATLAB codes and data files are available within Book Information.

  9. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Terra-FM1_Edition2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-01-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  10. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Terra-FM1_Edition1-CV)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2006-09-30] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  11. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Aqua-FM4_Edition1-CV)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  12. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Terra-FM2_Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-11-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  13. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_TRMM-PFM_Edition2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  14. CERES ERBE-like Instantaneous TOA Estimates (ES-8) in HDF (CER_ES8_Aqua-FM3_Edition2)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The ES-8 archival data product contains a 24-hour, single-satellite, instantaneous view of scanner fluxes at the top-of-atmosphere (TOA) reduced from spacecraft altitude unfiltered radiances using Earth Radiation Budget Experiment (ERBE) scanner Inversion algorithms and the ERBE shortwave (SW) and longwave (LW) Angular Distribution Models (ADMs). The ES-8 also includes the total (TOT), SW, LW, and window (WN) channel radiometric data; SW, LW, and WN unfiltered radiance values; and the ERBE scene identification for each measurement. These data are organized according to the CERES 3.3-second scan into 6.6-second records. As long as there is one valid scanner measurement within a record, the ES-8 record will be generated. The following CERES ES8 data sets are currently available: CER_ES8_TRMM-PFM_Edition1 CER_ES8_TRMM-PFM_Edition2 CER_ES8_TRMM-PFM_Transient-Ops2 CER_ES8_Terra-FM1_Edition1 CER_ES8_Terra-FM2_Edition1 CER_ES8_Terra-FM1_Edition2 CER_ES8_Terra-FM2_Edition2 CER_ES8_Aqua-FM3_Edition1 CER_ES8_Aqua-FM4_Edition1 CER_ES8_Aqua-FM3_Edition2 CER_ES8_Aqua-FM4_Edition2 CER_ES8_Aqua-FM3_Edition1-CV CER_ES8_Aqua-FM4_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV CER_ES8_Terra-FM1_Edition1-CV. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1997-12-27; Stop_Date=2005-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 day; Temporal_Resolution_Range=Daily - < Weekly].

  15. Solving Discipline and Classroom Management Problems: Methods and Models for Today's Teachers. 6th Edition

    ERIC Educational Resources Information Center

    Wolfgang, Charles H.

    2004-01-01

    Offering a wide range of methods and practical advice, this sixth edition equips teachers with tools they need to deal effectively with a range of discipline/management problems in the classroom--from minor misbehavior to serious assaults. The following features are included in this edition: (1) A new chapter discusses how to deal with and support…

  16. Teaching Outside the Box: How to Grab Your Students by Their Brains, 2nd Edition

    ERIC Educational Resources Information Center

    Johnson, LouAnne

    2011-01-01

    This second edition of the bestselling book includes practical suggestions for arranging your classroom, talking to students, avoiding the misbehavior cycle, and making your school a place where students learn and teachers teach. The book also contains enlivening Q&A from teachers, letters from students, and tips for grading. This new edition has…

  17. Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System.

    PubMed

    Nandal, Anjali; Mallon, Barbara; Telugu, Bhanu P

    2017-11-08

    Embryonic and induced pluripotent stem cells can self-renew and differentiate into multiple cell types of the body. The pluripotent cells are thus coveted for research in regenerative medicine and are currently in clinical trials for eye diseases, diabetes, heart diseases, and other disorders. The potential to differentiate into specialized cell types coupled with the recent advances in genome editing technologies including the CRISPR/Cas system have provided additional opportunities for tailoring the genome of iPSC for varied applications including disease modeling, gene therapy, and biasing pathways of differentiation, to name a few. Among the available editing technologies, the CRISPR/Cas9 from Streptococcus pyogenes has emerged as a tool of choice for site-specific editing of the eukaryotic genome. The CRISPRs are easily accessible, inexpensive, and highly efficient in engineering targeted edits. The system requires a Cas9 nuclease and a guide sequence (20-mer) specific to the genomic target abutting a 3-nucleotide "NGG" protospacer-adjacent-motif (PAM) for targeting Cas9 to the desired genomic locus, alongside a universal Cas9 binding tracer RNA (together called single guide RNA or sgRNA). Here we present a step-by-step protocol for efficient generation of feeder-independent and footprint-free iPSC and describe methodologies for genome editing of iPSC using the Cas9 ribonucleoprotein (RNP) complexes. The genome editing protocol is effective and can be easily multiplexed by pre-complexing sgRNAs for more than one target with the Cas9 protein and simultaneously delivering into the cells. Finally, we describe a simplified approach for identification and characterization of iPSCs with desired edits. Taken together, the outlined strategies are expected to streamline generation and editing of iPSC for manifold applications.

  18. Transportation Expressions

    DOT National Transportation Integrated Search

    1994-11-01

    This report compiles definitions of transportation terms used throughout the Department of Transportation and other US government agencies. This is the first edition of Transportation Expressions; future editions will be expanded in scope to include ...

  19. Adeno-associated virus inverted terminal repeats stimulate gene editing.

    PubMed

    Hirsch, M L

    2015-02-01

    Advancements in genome editing have relied on technologies to specifically damage DNA which, in turn, stimulates DNA repair including homologous recombination (HR). As off-target concerns complicate the therapeutic translation of site-specific DNA endonucleases, an alternative strategy to stimulate gene editing based on fragile DNA was investigated. To do this, an episomal gene-editing reporter was generated by a disruptive insertion of the adeno-associated virus (AAV) inverted terminal repeat (ITR) into the egfp gene. Compared with a non-structured DNA control sequence, the ITR induced DNA damage as evidenced by increased gamma-H2AX and Mre11 foci formation. As local DNA damage stimulates HR, ITR-mediated gene editing was investigated using DNA oligonucleotides as repair substrates. The AAV ITR stimulated gene editing >1000-fold in a replication-independent manner and was not biased by the polarity of the repair oligonucleotide. Analysis of additional human DNA sequences demonstrated stimulation of gene editing to varying degrees. In particular, inverted yet not direct, Alu repeats induced gene editing, suggesting a role for DNA structure in the repair event. Collectively, the results demonstrate that inverted DNA repeats stimulate gene editing via double-strand break repair in an episomal context and allude to efficient gene editing of the human chromosome using fragile DNA sequences.

  20. Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.

    PubMed

    Hong, HuiQi; An, Omer; Chan, Tim H M; Ng, Vanessa H E; Kwok, Hui Si; Lin, Jaymie S; Qi, Lihua; Han, Jian; Tay, Daryl J T; Tang, Sze Jing; Yang, Henry; Song, Yangyang; Bellido Molias, Fernando; Tenen, Daniel G; Chen, Leilei

    2018-05-18

    Adenosine-to-inosine (A-to-I) RNA editing entails the enzymatic deamination of adenosines to inosines by adenosine deaminases acting on RNA (ADARs). Dysregulated A-to-I editing has been implicated in various diseases, including cancers. However, the precise factors governing the A-to-I editing and their physiopathological implications remain as a long-standing question. Herein, we unravel that DEAH box helicase 9 (DHX9), at least partially dependent of its helicase activity, functions as a bidirectional regulator of A-to-I editing in cancer cells. Intriguingly, the ADAR substrate specificity determines the opposing effects of DHX9 on editing as DHX9 silencing preferentially represses editing of ADAR1-specific substrates, whereas augments ADAR2-specific substrate editing. Analysis of 11 cancer types from The Cancer Genome Atlas (TCGA) reveals a striking overexpression of DHX9 in tumors. Further, tumorigenicity studies demonstrate a helicase-dependent oncogenic role of DHX9 in cancer development. In sum, DHX9 constitutes a bidirectional regulatory mode in A-to-I editing, which is in part responsible for the dysregulated editome profile in cancer.

  1. Smithsonian Astrophysical Observatory (SAO) star catalog (Sao staff 1966, edition ADC 1989): Documentation for the machine-readable version

    NASA Technical Reports Server (NTRS)

    Roman, Nancy G.; Warren, Wayne H., Jr.

    1989-01-01

    An updated, corrected, and extended machine readable version of the catalog is described. Published and unpublished errors discovered in the previous version were corrected, and multiple star and supplemental BD identifications were added to stars where more than one SAO entry has the same Durchmusterung number. Henry Draper Extension (HDE) numbers were added for stars found in both volumes of the extension. Data for duplicate SAO entries (those referring to the same star) were flagged. J2000 positions in usual units and in radians were added.

  2. Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes.

    PubMed

    Hess, Gaelen T; Tycko, Josh; Yao, David; Bassik, Michael C

    2017-10-05

    The past several years have seen an explosion in development of applications for the CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to recruitment of a range of DNA and chromatin-modifying enzymes. While homology-directed repair (HDR) coupled with Cas9 nuclease cleavage has been used with great success to repair and re-write genomes, recently developed base-editing systems present a useful orthogonal strategy to engineer nucleotide substitutions. Base editing relies on recruitment of cytidine deaminases to introduce changes (rather than double-stranded breaks and donor templates) and offers potential improvements in efficiency while limiting damage and simplifying the delivery of editing machinery. At the same time, these systems enable novel mutagenesis strategies to introduce sequence diversity for engineering and discovery. Here, we review the different base-editing platforms, including their deaminase recruitment strategies and editing outcomes, and compare them to other CRISPR genome-editing technologies. Additionally, we discuss how these systems have been applied in therapeutic, engineering, and research settings. Lastly, we explore future directions of this emerging technology. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Your Reading: A Booklist for Junior High and Middle School Students. Sixth Edition.

    ERIC Educational Resources Information Center

    Christensen, Jane, Ed.

    With many annotations written or edited by students, this booklist contains 3,100 citations of fiction and nonfiction publications for adolescents. Most entries were published within the past few years, although well-written older books are also included. The annotations, which include appropriate age ranges, are categorized as follows:…

  4. Your Reading: A Booklist for Junior High Students. Fifth Edition.

    ERIC Educational Resources Information Center

    Walker, Jerry L., Ed.

    Written for adolescents, this most recent edition contains annotations for over 1,500 publications in the fiction and nonfiction categories. Most entries have been published in the past few years, though well-written older books are also included. Topics covered under fiction include books on adventure, family life, freedom, friendship, fantasy,…

  5. Idaho Library Laws, 1999-2000. Full Edition.

    ERIC Educational Resources Information Center

    Idaho State Library, Boise.

    This new edition of the Idaho Library Laws contains changes through the 1998 legislative session and includes Idaho Code sections that legally affect city, school-community or district libraries, or the Idaho State Library. These sections include the basic library laws in Idaho Code Title 33, Chapters 25, 26, and 27, additional sections of the law…

  6. Health Education Teaching Ideas: Secondary. Revised Edition.

    ERIC Educational Resources Information Center

    Loya, Richard, Ed.; Bensley, Loren B., Jr., Ed.

    Part I of this teaching guide contains teaching strategies which originally appeared in the "Journal of Health Education" (JHE) and were included in the first edition of this guide, published in 1983. Part II includes teaching strategies published in JHE since 1983. The guide is designed to be a reference for those seeking workable ideas in…

  7. Projections of Education Statistics to 2018. Thirty-Seventh Edition. NCES 2009-062

    ERIC Educational Resources Information Center

    Hussar, William J.; Bailey, Tabitha M.

    2009-01-01

    "Projections of Education Statistics to 2018" is the 37th report in a series begun in 1964. It includes statistics on elementary and secondary schools and degree-granting institutions. Included are projections of enrollment, graduates, teachers, and expenditures to the year 2018. This is the first edition of the "Projections of…

  8. Comparison of Visual Assessment of Breast Density in BI-RADS 4th and 5th Editions With Automated Volumetric Measurement.

    PubMed

    Youk, Ji Hyun; Kim, So Jung; Son, Eun Ju; Gweon, Hye Mi; Kim, Jeong-Ah

    2017-09-01

    The purpose of this study was to compare visual assessments of mammographic breast density by radiologists using BI-RADS 4th and 5th editions in correlation with automated volumetric breast density measurements. A total of 337 consecutive full-field digital mammographic examinations with standard views were retrospectively assessed by two radiologists for mammographic breast density according to BI-RADS 4th and 5th editions. Fully automated measurement of the volume of fibroglandular tissue and total breast and percentage breast density was performed with a commercially available software program. Interobserver and intraobserver agreement was assessed with kappa statistics. The distributions of breast density categories for both editions of BI-RADS were compared and correlated with volumetric data. Interobserver agreement on breast density category was moderate to substantial (κ = 0.58-0.63) with use of BI-RADS 4th edition and substantial (κ = 0.63-0.66) with use of the 5th edition but without significant difference between the two editions. For intraobserver agreement between the two editions, the distributions of density category were significantly different (p < 0.0001), the proportions of dense breast increased, and the proportion of fatty breast decreased with use of the 5th edition compared with the 4th edition (p < 0.0001). All volumetric breast density data, including percentage breast density, were significantly different among density categories (p < 0.0001) and had significant correlation with visual assessment for both editions of BI-RADS (p < 0.01). Assessment using BI-RADS 5th edition revealed a higher proportion of dense breast than assessment using BI-RADS 4th edition. Nevertheless, automated volumetric density assessment had good correlation with visual assessment for both editions of BI-RADS.

  9. Facing Racism in Education. Second Edition. Harvard Educational Review Reprint Series No. 28.

    ERIC Educational Resources Information Center

    Beauboeuf-Lafontant, Tamara, Ed.; Augustine, D. Smith, Ed.

    Since the publication of the first edition of this book, the nation has moved from silence about the reality of racism to the denial of its existence. Talking about racism is never easy, but the eight chapters from the original edition and eight new chapters provide insight into racism in education and strategies for change. Included are: (1)…

  10. Automatically Detecting Likely Edits in Clinical Notes Created Using Automatic Speech Recognition

    PubMed Central

    Lybarger, Kevin; Ostendorf, Mari; Yetisgen, Meliha

    2017-01-01

    The use of automatic speech recognition (ASR) to create clinical notes has the potential to reduce costs associated with note creation for electronic medical records, but at current system accuracy levels, post-editing by practitioners is needed to ensure note quality. Aiming to reduce the time required to edit ASR transcripts, this paper investigates novel methods for automatic detection of edit regions within the transcripts, including both putative ASR errors but also regions that are targets for cleanup or rephrasing. We create detection models using logistic regression and conditional random field models, exploring a variety of text-based features that consider the structure of clinical notes and exploit the medical context. Different medical text resources are used to improve feature extraction. Experimental results on a large corpus of practitioner-edited clinical notes show that 67% of sentence-level edits and 45% of word-level edits can be detected with a false detection rate of 15%. PMID:29854187

  11. Traffic control systems handbook

    DOT National Transportation Integrated Search

    2005-10-01

    The 2005 edition of "Traffic Control Systems Handbook" updates the 1996 edition (FHWA-SA-96-032). It serves as a basic reference in planning, designing and implementing traffic control systems. Specific chapters include introduction, summary of avail...

  12. A-to-I RNA editing is developmentally regulated and generally adaptive for sexual reproduction in Neurospora crassa

    PubMed Central

    Li, Yang; Chen, Daipeng; Qi, Zhaomei; Wang, Qinhu; Wang, Jianhua; Jiang, Cong; Xu, Jin-Rong

    2017-01-01

    Although fungi lack adenosine deaminase acting on RNA (ADAR) enzymes, adenosine to inosine (A-to-I) RNA editing was reported recently in Fusarium graminearum during sexual reproduction. In this study, we profiled the A-to-I editing landscape and characterized its functional and adaptive properties in the model filamentous fungus Neurospora crassa. A total of 40,677 A-to-I editing sites were identified, and approximately half of them displayed stage-specific editing or editing levels at different sexual stages. RNA-sequencing analysis with the Δstc-1 and Δsad-1 mutants confirmed A-to-I editing occurred before ascus development but became more prevalent during ascosporogenesis. Besides fungal-specific sequence and secondary structure preference, 63.5% of A-to-I editing sites were in the coding regions and 81.3% of them resulted in nonsynonymous recoding, resulting in a significant increase in the proteome complexity. Many genes involved in RNA silencing, DNA methylation, and histone modifications had extensive recoding, including sad-1, sms-3, qde-1, and dim-2. Fifty pseudogenes harbor premature stop codons that require A-to-I editing to encode full-length proteins. Unlike in humans, nonsynonymous editing events in N. crassa are generally beneficial and favored by positive selection. Almost half of the nonsynonymous editing sites in N. crassa are conserved and edited in Neurospora tetrasperma. Furthermore, hundreds of them are conserved in F. graminearum and had higher editing levels. Two unknown genes with editing sites conserved between Neurospora and Fusarium were experimentally shown to be important for ascosporogenesis. This study comprehensively analyzed A-to-I editing in N. crassa and showed that RNA editing is stage-specific and generally adaptive, and may be functionally related to repeat induced point mutation and meiotic silencing by unpaired DNA. PMID:28847945

  13. Genome Editing of Monogenic Neuromuscular Diseases: A Systematic Review.

    PubMed

    Long, Chengzu; Amoasii, Leonela; Bassel-Duby, Rhonda; Olson, Eric N

    2016-11-01

    Muscle weakness, the most common symptom of neuromuscular disease, may result from muscle dysfunction or may be caused indirectly by neuronal and neuromuscular junction abnormalities. To date, more than 780 monogenic neuromuscular diseases, linked to 417 different genes, have been identified in humans. Genome-editing methods, especially the CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 (CRISPR-associated protein 9) system, hold clinical potential for curing many monogenic disorders, including neuromuscular diseases such as Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1. To provide an overview of genome-editing approaches; to summarize published reports on the feasibility, efficacy, and safety of current genome-editing methods as they relate to the potential correction of monogenic neuromuscular diseases; and to highlight scientific and clinical opportunities and obstacles toward permanent correction of disease-causing mutations responsible for monogenic neuromuscular diseases by genome editing. PubMed and Google Scholar were searched for articles published from June 30, 1989, through June 9, 2016, using the following keywords: genome editing, CRISPR-Cas9, neuromuscular disease, Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1. The following sources were reviewed: 341 articles describing different approaches to edit mammalian genomes; 330 articles describing CRISPR-Cas9-mediated genome editing in cell culture lines (in vitro) and animal models (in vivo); 16 websites used to generate single-guide RNA; 4 websites for off-target effects; and 382 articles describing viral and nonviral delivery systems. Articles describing neuromuscular diseases, including Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1, were also reviewed. Multiple proof-of-concept studies reveal the feasibility and efficacy of genome-editing-meditated correction of monogenic neuromuscular diseases in cultured cells and animal models. Genome editing is a rapidly evolving technology with enormous translational potential once efficacy, delivery, and safety issues are addressed. The clinical impact of this technology is that genome editing can permanently correct disease-causing mutations and circumvent the hurdles of traditional gene- and cell-based therapies.

  14. Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum

    PubMed Central

    Li, Yong

    2017-01-01

    RNA editing is a rare post-transcriptional event that provides cells with an additional level of gene expression regulation. It has been implicated in various processes including adaptation, viral defence and RNA interference; however, its potential role as a mechanism in acclimatization has just recently been recognised. Here, we show that RNA editing occurs in 1.6% of all nuclear-encoded genes of Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals. All base-substitution edit types were present, and statistically significant motifs were associated with three edit types. Strikingly, a subset of genes exhibited condition-specific editing patterns in response to different stressors that resulted in significant increases of non-synonymous changes. We posit that this previously unrecognised mechanism extends this organism’s capability to respond to stress beyond what is encoded by the genome. This in turn may provide further acclimatization capacity to these organisms, and by extension, their coral hosts. PMID:28245292

  15. [The application of genome editing in identification of plant gene function and crop breeding].

    PubMed

    Zhou, Xiang-chun; Xing, Yong-zhong

    2016-03-01

    Plant genome can be modified via current biotechnology with high specificity and excellent efficiency. Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system are the key engineered nucleases used in the genome editing. Genome editing techniques enable gene targeted mutagenesis, gene knock-out, gene insertion or replacement at the target sites during the endogenous DNA repair process, including non-homologous end joining (NHEJ) and homologous recombination (HR), triggered by the induction of DNA double-strand break (DSB). Genome editing has been successfully applied in the genome modification of diverse plant species, such as Arabidopsis thaliana, Oryza sativa, and Nicotiana tabacum. In this review, we summarize the application of genome editing in identification of plant gene function and crop breeding. Moreover, we also discuss the improving points of genome editing in crop precision genetic improvement for further study.

  16. Genome editing via delivery of Cas9 ribonucleoprotein.

    PubMed

    DeWitt, Mark A; Corn, Jacob E; Carroll, Dana

    2017-05-15

    The CRISPR-Cas genome editing system is very powerful. The format of the CRISPR reagents and the means of delivery are often important factors in targeting efficiency. Delivery of recombinant Cas9 protein and guide RNA (gRNA) as a preformed ribonucleoprotein (RNP) complex has recently emerged as a powerful and general approach to genome editing. Here we outline methods to produce and deliver Cas9 RNPs. A donor DNA carrying desired sequence changes can also be included to program precise sequence introduction or replacement. RNP delivery limits exposure to genome editing reagents, reduces off-target events, drives high rates of homology-dependent repair, and can be applied to embryos to rapidly generate animal models. RNP delivery thus minimizes some of the pitfalls of alternative editing modalities and is rapidly being adopted by the genome editing community. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. [Genome editing of industrial microorganism].

    PubMed

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  18. Book Review: Book review

    NASA Astrophysics Data System (ADS)

    Clevers, Jan G. P. W.

    2016-09-01

    For many years a good introductory book for undergraduate and postgraduate students on remote sensing of the Earth's land surface, which was not starting with an emphasis on traditional photographic techniques, was missing. In 2010 the first edition of the book Fundamentals of Satellite Remote Sensing by Emilio Chuvieco and Alfredo Huete was published by CRC Press and it was filling this gap. Now the second edition by Emilio Chuvieco was published by CRC Press. This second edition is made more attractive by the use of colour and including colour illustrations instead of the black-and-white ones in the first edition.

  19. Academic Vocabulary Learning in First Through Third Grade in Low-Income Schools: Effects of Automated Supplemental Instruction.

    PubMed

    Goldstein, Howard; Ziolkowski, Robyn A; Bojczyk, Kathryn E; Marty, Ana; Schneider, Naomi; Harpring, Jayme; Haring, Christa D

    2017-11-09

    This study investigated cumulative effects of language learning, specifically whether prior vocabulary knowledge or special education status moderated the effects of academic vocabulary instruction in high-poverty schools. Effects of a supplemental intervention targeting academic vocabulary in first through third grades were evaluated with 241 students (6-9 years old) from low-income families, 48% of whom were retained for the 3-year study duration. Students were randomly assigned to vocabulary instruction or comparison groups. Curriculum-based measures of word recognition, receptive identification, expressive labeling, and decontextualized definitions showed large effects for multiple levels of word learning. Hierarchical linear modeling revealed that students with higher initial Peabody Picture Vocabulary Test-Fourth Edition scores (Dunn & Dunn, 2007) demonstrated greater word learning, whereas students with special needs demonstrated less growth in vocabulary. This model of vocabulary instruction can be applied efficiently in high-poverty schools through an automated, easily implemented adjunct to reading instruction in the early grades and holds promise for reducing gaps in vocabulary development.

  20. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.

    PubMed

    McGlade, Erin; Agoston, Anna Monica; DiMuzio, Jennifer; Kizaki, Miho; Nakazaki, Eri; Kamiya, Toshikazu; Yurgelun-Todd, Deborah

    2015-07-15

    This study assessed the effects of citicoline, a nutraceutical, on attention, psychomotor function, and impulsivity in healthy adolescent males. Seventy-five healthy adolescent males were randomly assigned to either the citicoline group (n = 51 with 250 or 500 mg citicoline) or placebo (n = 24). Participants completed the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II) at baseline and after 28 days of supplementation. Individuals receiving citicoline exhibited improved attention (p = 0.02) and increased psychomotor speed (p = 0.03) compared with those receiving placebo. Higher weight-adjusted dose significantly predicted increased accuracy on an attention task (p = 0.01), improved signal detectability on a computerized attention task (p = 0.03), and decreased impulsivity (p = 0.01). Adolescent males receiving 28 days of Cognizin® citicoline showed improved attention and psychomotor speed and reduced impulsivity compared to adolescent males who received placebo. © 2015 SAGE Publications.

  1. Aspen Handbook on the Media, 1975-76 Edition. Research, Publications, Organizations, Foundation Support, Government Review, International Communication Agencies.

    ERIC Educational Resources Information Center

    Rivers, William L., Ed.; Slater, William T., Ed.

    The second edition of this guide to media organization and media research doubles previous listings and includes new sections on international organizations, law school programs dealing with the media, and an expanded section on government activities. Basic listings include universities and other institutions conducting major media research,…

  2. Why You're You, Teacher's Edition. Probing the Natural World/3.

    ERIC Educational Resources Information Center

    Florida State Univ., Tallahassee. Dept. of Science Education.

    The teacher's edition for the Intermediate Science Curriculum Study Level III unit entitled "Why You're You" provides specific suggestions for teaching the seven chapters included in the unit. The unit deals primarily with the concepts of genetics and a brief discussion is included in the beginning about some of the basic ideas in this…

  3. Peak with Books: An Early Childhood Resource for Balanced Literacy. Third Edition.

    ERIC Educational Resources Information Center

    Nelsen, Marjorie R.; Nelsen-Parish, Jan

    This book shows how to use popular children's literature to build reading, writing, and cognitive skills in an inquiry-based environment. This third edition has been expanded to include first and second grades. New features include: (1) new emphasis on culturally diverse storybooks; (2) a description of the experiential learning inquiry process;…

  4. Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

    PubMed Central

    Wang, Yumeng; Xu, Xiaoyan; Yu, Shuangxing; Jeong, Kang Jin; Zhou, Zhicheng; Han, Leng; Tsang, Yiu Huen; Li, Jun; Chen, Hu; Mangala, Lingegowda S.; Yuan, Yuan; Eterovic, A. Karina; Lu, Yiling; Sood, Anil K.; Scott, Kenneth L.; Mills, Gordon B.; Liang, Han

    2017-01-01

    RNA editing, a widespread post-transcriptional mechanism, has emerged as a new player in cancer biology. Recent studies have reported key roles for individual miRNA editing events, but a comprehensive picture of miRNA editing in human cancers remains largely unexplored. Here, we systematically characterized the miRNA editing profiles of 8595 samples across 20 cancer types from miRNA sequencing data of The Cancer Genome Atlas and identified 19 adenosine-to-inosine (A-to-I) RNA editing hotspots. We independently validated 15 of them by perturbation experiments in several cancer cell lines. These miRNA editing events show extensive correlations with key clinical variables (e.g., tumor subtype, disease stage, and patient survival time) and other molecular drivers. Focusing on the RNA editing hotspot in miR-200b, a key tumor metastasis suppressor, we found that the miR-200b editing level correlates with patient prognosis opposite to the pattern observed for the wild-type miR-200b expression. We further experimentally showed that, in contrast to wild-type miRNA, the edited miR-200b can promote cell invasion and migration through its impaired ability to inhibit ZEB1/ZEB2 and acquired concomitant ability to repress new targets, including LIFR, a well-characterized metastasis suppressor. Our study highlights the importance of miRNA editing in gene regulation and suggests its potential as a biomarker for cancer prognosis and therapy. PMID:28411194

  5. Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

    PubMed Central

    Liu, Huiquan; Wang, Qinhu; He, Yi; Chen, Lingfeng; Hao, Chaofeng; Jiang, Cong; Li, Yang; Dai, Yafeng; Kang, Zhensheng; Xu, Jin-Rong

    2016-01-01

    Yeasts and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and are believed to lack A-to-I RNA editing, which is the most prevalent editing of mRNA in animals. However, during this study with the PUK1 (FGRRES_01058) pseudokinase gene important for sexual reproduction in Fusarium graminearum, we found that two tandem stop codons, UA1831GUA1834G, in its kinase domain were changed to UG1831GUG1834G by RNA editing in perithecia. To confirm A-to-I editing of PUK1 transcripts, strand-specific RNA-seq data were generated with RNA isolated from conidia, hyphae, and perithecia. PUK1 was almost specifically expressed in perithecia, and 90% of transcripts were edited to UG1831GUG1834G. Genome-wide analysis identified 26,056 perithecium-specific A-to-I editing sites. Unlike those in animals, 70.5% of A-to-I editing sites in F. graminearum occur in coding regions, and more than two-thirds of them result in amino acid changes, including editing of 69 PUK1-like pseudogenes with stop codons in ORFs. PUK1 orthologs and other pseudogenes also displayed stage-specific expression and editing in Neurospora crassa and F. verticillioides. Furthermore, F. graminearum differs from animals in the sequence preference and structure selectivity of A-to-I editing sites. Whereas A's embedded in RNA stems are targeted by ADARs, RNA editing in F. graminearum preferentially targets A's in hairpin loops, which is similar to the anticodon loop of tRNA targeted by adenosine deaminases acting on tRNA (ADATs). Overall, our results showed that A-to-I RNA editing occurs specifically during sexual reproduction and mainly in the coding regions in filamentous ascomycetes, involving adenosine deamination mechanisms distinct from metazoan ADARs. PMID:26934920

  6. Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition

    PubMed Central

    Madina, Bhaskara R.; Kumar, Vikas; Metz, Richard; Mooers, Blaine H.M.; Bundschuh, Ralf; Cruz-Reyes, Jorge

    2014-01-01

    Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3′-to-5′ in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms. Here, we address compositionally related factors, collectively known as the mitochondrial RNA-binding complex 1 (MRB1) or gRNA-binding complex (GRBC), that contain gRNA, have a dynamic protein composition, and transiently associate with several mitochondrial factors including RNA editing core complexes (RECC) and ribosomes. MRB1 controls editing by still unknown mechanisms. We performed the first next-generation sequencing study of native subcomplexes of MRB1, immunoselected via either RNA helicase 2 (REH2), that binds RNA and associates with unwinding activity, or MRB3010, that affects an early editing step. The particles contain either REH2 or MRB3010 but share the core GAP1 and other proteins detected by RNA photo-crosslinking. Analyses of the first editing blocks indicate an enrichment of several initiating gRNAs in the MRB3010-purified complex. Our data also indicate fast evolution of mRNA 3′ ends and strain-specific alternative 3′ editing within 3′ UTR or C-terminal protein-coding sequence that could impact mitochondrial physiology. Moreover, we found robust specific copurification of edited and pre-edited mRNAs, suggesting that these particles may bind both mRNA and gRNA editing substrates. We propose that multiple subcomplexes of MRB1 with different RNA/protein composition serve as a scaffold for specific assembly of editing substrates and RECC, thereby forming the editing holoenzyme. The MRB3010-subcomplex may promote early editing through its preferential recruitment of initiating gRNAs. PMID:24865612

  7. CRISPR-Cpf1: A New Tool for Plant Genome Editing.

    PubMed

    Zaidi, Syed Shan-E-Ali; Mahfouz, Magdy M; Mansoor, Shahid

    2017-07-01

    Clustered regularly interspaced palindromic repeats (CRISPR)-CRISPR-associated proteins (CRISPR-Cas), a groundbreaking genome-engineering tool, has facilitated targeted trait improvement in plants. Recently, CRISPR-CRISPR from Prevotella and Francisella 1 (Cpf1) has emerged as a new tool for efficient genome editing, including DNA-free editing in plants, with higher efficiency, specificity, and potentially wider applications than CRISPR-Cas9. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature.

    PubMed

    Pawlak, R; Lester, S E; Babatunde, T

    2014-05-01

    Individuals following vegetarian diets are at risk for developing vitamin B12 deficiency owing to suboptimal intake. As vitamin B12 is essential for the synthesis of nucleic acids, erythrocytes and in the maintenance of myelin, deficiency may result in a variety of symptoms. Some of these symptoms may be severe while others may be irreversible. The objective of this review was to assess vitamin B12 deficiency, based on reported serum vitamin B12, among individuals adhering to different types of vegetarian diets. A systematic literature search was carried out using multiple search engines including PubMed, Medline, CINAHL plus, ERIC, Nursing and Allied Health Collection and Nursing/Academic Edition. The inclusion criteria consisted of original studies that assessed serum vitamin B12, studies written in English, non-case studies and studies that reported actual percentages of vitamin B12 deficiency. Forty research studies were included. The deficiency prevalence among infants reached 45%. The deficiency among the children and adolescents ranged from 0 to 33.3%. Deficiency among pregnant women ranged from 17 to 39%, dependent on the trimester. Adults and elderly individuals had a deficiency range of 0-86.5%. Higher deficiency prevalence was reported in vegans than in other vegetarians. Thus, with few exceptions, the reviewed studies documented relatively high deficiency prevalence among vegetarians. Vegans who do not ingest vitamin B12 supplements were found to be at especially high risk. Vegetarians, especially vegans, should give strong consideration to the use of vitamin B12 supplements to ensure adequate vitamin B12 intake. Vegetarians, regardless of the type of vegetarian diet they adhere to, should be screened for vitamin B12 deficiency.

  9. Efficient genome editing of differentiated renal epithelial cells.

    PubMed

    Hofherr, Alexis; Busch, Tilman; Huber, Nora; Nold, Andreas; Bohn, Albert; Viau, Amandine; Bienaimé, Frank; Kuehn, E Wolfgang; Arnold, Sebastian J; Köttgen, Michael

    2017-02-01

    Recent advances in genome editing technologies have enabled the rapid and precise manipulation of genomes, including the targeted introduction, alteration, and removal of genomic sequences. However, respective methods have been described mainly in non-differentiated or haploid cell types. Genome editing of well-differentiated renal epithelial cells has been hampered by a range of technological issues, including optimal design, efficient expression of multiple genome editing constructs, attainable mutation rates, and best screening strategies. Here, we present an easily implementable workflow for the rapid generation of targeted heterozygous and homozygous genomic sequence alterations in renal cells using transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeat (CRISPR) system. We demonstrate the versatility of established protocols by generating novel cellular models for studying autosomal dominant polycystic kidney disease (ADPKD). Furthermore, we show that cell culture-validated genetic modifications can be readily applied to mouse embryonic stem cells (mESCs) for the generation of corresponding mouse models. The described procedure for efficient genome editing can be applied to any cell type to study physiological and pathophysiological functions in the context of precisely engineered genotypes.

  10. 76 FR 68740 - Trademark Manual of Examining Procedure, Eighth Edition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... in the USPTO. The TMEP contains guidelines for examining attorneys and materials in the nature of... statement of USPTO policy, to the extent that there is any conflict. The eighth edition also includes a...

  11. Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion

    PubMed Central

    Martin, Geoffrey A; Tsim, Selina; Kidd, Andrew C; Foster, John E; McLoone, Philip; Chalmers, Anthony

    2018-01-01

    Introduction Non-expansile lung (NEL) is a common cause of talc pleurodesis (TP) failure in malignant pleural effusion (MPE), but is often occult prior to drainage. Reliable detection of NEL would allow patients to be allocated between intrapleural catheter (IPC) and TP. High pleural elastance (PEL) has been associated with NEL in observational studies. Pre-EDIT is a randomised feasibility trial of elastance-directed IPC or TP (EDIT) management using a novel, purpose-built digital pleural manometer (Rocket Medical, UK). Methods and analysis Consecutive patients with MPE without prior evidence of NEL or preference for IPC will be randomised 1:1 between EDIT management and standard care (an attempt at TP). The primary objective is to determine whether sufficient numbers of patients (defined as 30 within 12 months (or 15 over 6 months)) can be recruited and randomised to justify a subsequent phase III trial testing the efficacy of EDIT management. Secondary objectives include safety, technical feasibility and validation of study design elements, including the definition of PEL using 4D pleural MRI before and after fluid aspiration. EDIT involves PEL assessment during a large volume pleural fluid aspiration, followed by an attempt at TP or placement of an IPC within 24 hours. Patients will be allocated to IPC if the rolling average PEL sustained over at least 250 mL fluid aspirated (PEL250) is ≥ 14.5 cm H2O/L. Ethics and dissemination Pre-EDIT was approved by the West of Scotland Regional Ethics Committee on 8 March 2017 (Ref: 17/WS/0042). Results will be presented at scientific meetings and published in peer-reviewed journals. Trial registration number NCT03319186; Pre-results. PMID:29862030

  12. In Vivo Detection of 15N-Coupled Protons in Rat Brain by ISIS Localization and Multiple-Quantum Editing

    NASA Astrophysics Data System (ADS)

    Kanamori, Keiko; Ross, Brian D.

    1999-08-01

    Three-dimensional image-selected in vivo spectroscopy (ISIS) was combined with phase-cycled 1H-15N heteronuclear multiple-quantum coherence (HMQC) transfer NMR for localized selective observation of protons J-coupled to 15N in phantoms and in vivo. The ISIS-HMQC sequence, supplemented by jump-return water suppression, permitted localized selective observation of 2-5 μmol of [15Nindole]tryptophan, a precursor of the neurotransmitter serotonin, through the 15N-coupled proton in 20-40 min of acquisition in vitro at 4.7 T. In vivo, the amide proton of [5-15N]glutamine was selectively observed in the brain of spontaneously breathing 15NH4+-infused rats, using a volume probe with homogeneous 1H and 15N fields. Signal recovery after three-dimensional localization was 72-82% in phantoms and 59 ± 4% in vivo. The result demonstrates that localized selective observation of 15N-coupled protons, with complete cancellation of all other protons except water, can be achieved in spontaneously breathing animals by the ISIS-HMQC sequence. This sequence performs both volume selection and heteronuclear editing through an addition/subtraction scheme and predicts the highest intrinsic sensitivity for detection of 15N-coupled protons in the selected volume. The advantages and limitations of this method for in vivo application are compared to those of other localized editing techniques currently in use for non-exchanging protons.

  13. Modern Genome Editing Technologies in Huntington's Disease Research.

    PubMed

    Malankhanova, Tuyana B; Malakhova, Anastasia A; Medvedev, Sergey P; Zakian, Suren M

    2017-01-01

    The development of new revolutionary technologies for directed gene editing has made it possible to thoroughly model and study NgAgo human diseases at the cellular and molecular levels. Gene editing tools like ZFN, TALEN, CRISPR-based systems, NgAgo and SGN can introduce different modifications. In gene sequences and regulate gene expression in different types of cells including induced pluripotent stem cells (iPSCs). These tools can be successfully used for Huntington's disease (HD) modeling, for example, to generate isogenic cell lines bearing different numbers of CAG repeats or to correct the mutation causing the disease. This review presents common genome editing technologies and summarizes the progress made in using them in HD and other hereditary diseases. Furthermore, we will discuss prospects and limitations of genome editing in understanding HD pathology.

  14. The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial.

    PubMed

    Strand, Tor A; Ulak, Manjeswori; Chandyo, Ram K; Kvestad, Ingrid; Hysing, Mari; Shrestha, Merina; Basnet, Sudha; Ranjitkar, Suman; Shrestha, Laxman; Shrestha, Prakash S

    2017-04-21

    Vitamin B 12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B 12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily supplementation of vitamin B 12 on the neurodevelopment and growth of young children in Nepal. We are conducting an individually randomized, double-blind, placebo-controlled trial with 600 marginally stunted children 6-11 months old (length for age less than -1 z-score). Children are randomized to receive a lipid-based paste containing vitamin B 12 or placebo daily for 12 months. The main outcomes are changes in growth (z-scores) and in neurodevelopment measured by the Bayley Scales of Infant and Toddler Development, Third Edition, from baseline until the end of the study. If vitamin B 12 supplementation benefits early child development and growth, this will have consequences for dietary recommendations for malnourished children worldwide. ClinicalTrials.gov Identifier: NCT02272842 . Registered on 21 October 2014. Universal Trial Number: U1111-1161-5187. Registered on 8 September 2014.

  15. Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial

    PubMed Central

    Sun, Caihong; Zou, Mingyang; Zhao, Dong; Xia, Wei; Wu, Lijie

    2016-01-01

    Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial and participated in three months of structured teaching. Forty-four children were treated with 400 μg folic acid (two times/daily) for a period of three months during their structured teaching (intervention group), while the remaining 22 children were not given any supplement for the duration of the study (control group). The Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile-third edition (PEP-3) were measured at the beginning and end of the treatment period. Folic acid, homocysteine, and glutathione metabolism in plasma were measured before and after treatment in 29 autistic children randomly selected from the intervention group and were compared with 29 age-matched unaffected children (typical developmental group). The results illustrated folic acid intervention improved autism symptoms towards sociability, cognitive verbal/preverbal, receptive language, and affective expression and communication. Furthermore, this treatment also improved the concentrations of folic acid, homocysteine, and normalized glutathione redox metabolism. Folic acid supplementation may have a certain role in the treatment of children with autism. PMID:27338456

  16. Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial.

    PubMed

    Sun, Caihong; Zou, Mingyang; Zhao, Dong; Xia, Wei; Wu, Lijie

    2016-06-07

    Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial and participated in three months of structured teaching. Forty-four children were treated with 400 μg folic acid (two times/daily) for a period of three months during their structured teaching (intervention group), while the remaining 22 children were not given any supplement for the duration of the study (control group). The Autism Treatment Evaluation Checklist (ATEC) and Psychoeducational Profile-third edition (PEP-3) were measured at the beginning and end of the treatment period. Folic acid, homocysteine, and glutathione metabolism in plasma were measured before and after treatment in 29 autistic children randomly selected from the intervention group and were compared with 29 age-matched unaffected children (typical developmental group). The results illustrated folic acid intervention improved autism symptoms towards sociability, cognitive verbal/preverbal, receptive language, and affective expression and communication. Furthermore, this treatment also improved the concentrations of folic acid, homocysteine, and normalized glutathione redox metabolism. Folic acid supplementation may have a certain role in the treatment of children with autism.

  17. Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial.

    PubMed

    Meldrum, Suzanne J; D'Vaz, Nina; Simmer, Karen; Dunstan, Janet A; Hird, Kathryn; Prescott, Susan L

    2012-10-28

    n-3 Long-chain PUFA (LC-PUFA) intake during infancy is important for neurodevelopment; however, previous studies of n-3 LC-PUFA supplementation have been inconclusive possibly due to an insufficient dose and limited methods of assessment. The present study aimed to evaluate the effects of direct supplementation with high-dose fish oil (FO) on infant neurodevelopmental outcomes and language. In the present randomised, double-blind, placebo-controlled trial, 420 healthy term infants were assigned to receive a DHA-enriched FO supplement (containing at least 250 mg DHA/d and 60 mg EPA/d) or a placebo (olive oil) from birth to 6 months. Assessment occurred at 18 months via the Bayley Scales of Infant and Toddler Development (3rd edition; BSID-III) and the Child Behavior Checklist. Language assessment occurred at 12 and 18 months via the Macarthur-Bates Communicative Development Inventory. The FO group had significantly higher erythrocyte DHA (P = 0·03) and plasma phospholipid DHA (P = 0·01) levels at 6 months of age relative to placebo. In a small subset analysis (about 40% of the total population), children in the FO group had significantly higher percentile ranks of both later developing gestures at 12 and 18 months (P = 0·007; P = 0·002, respectively) and the total number of gestures (P = 0·023; P = 0·006, respectively). There was no significant difference between the groups in the standard or composite scores of the BSID-III. The results suggest that improved postnatal n-3 LC-PUFA intake in the first 6 months of life using high-dose infant FO supplementation was not beneficial to global infant neurodevelopment. However, some indication of benefits to early communicative development was observed.

  18. Gene Editing of Microalgae: Scientific Progress and Regulatory Challenges in Europe

    PubMed Central

    Spicer, Andrew

    2018-01-01

    It is abundantly clear that the development of gene editing technologies, represents a potentially powerful force for good with regard to human and animal health and addressing the challenges we continue to face in a growing global population. This now includes the development of approaches to modify microalgal strains for potential improvements in productivity, robustness, harvestability, processability, nutritional composition, and application. The rapid emergence and ongoing developments in this area demand a timely review and revision of the current definitions and regulations around genetically modified organisms (GMOs), particularly within Europe. Current practices within the EU provide exemptions from the GMO directives for organisms, including crop plants and micro-organisms that are produced through chemical or UV/radiation mutagenesis. However, organisms generated through gene editing, including microalgae, where only genetic changes in native genes are made, remain currently under the GMO umbrella; they are, as such, excluded from practical and commercial opportunities in the EU. In this review, we will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GM microalgae in Europe. PMID:29509719

  19. Gene Editing of Microalgae: Scientific Progress and Regulatory Challenges in Europe.

    PubMed

    Spicer, Andrew; Molnar, Attila

    2018-03-06

    It is abundantly clear that the development of gene editing technologies, represents a potentially powerful force for good with regard to human and animal health and addressing the challenges we continue to face in a growing global population. This now includes the development of approaches to modify microalgal strains for potential improvements in productivity, robustness, harvestability, processability, nutritional composition, and application. The rapid emergence and ongoing developments in this area demand a timely review and revision of the current definitions and regulations around genetically modified organisms (GMOs), particularly within Europe. Current practices within the EU provide exemptions from the GMO directives for organisms, including crop plants and micro-organisms that are produced through chemical or UV/radiation mutagenesis. However, organisms generated through gene editing, including microalgae, where only genetic changes in native genes are made, remain currently under the GMO umbrella; they are, as such, excluded from practical and commercial opportunities in the EU. In this review, we will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GM microalgae in Europe.

  20. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

    DOEpatents

    Church, George M.; Esvelt, Kevin; Mali, Prashant

    2017-03-07

    Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.

  1. Automated search of control points in surface-based morphometry.

    PubMed

    Canna, Antonietta; Russo, Andrea G; Ponticorvo, Sara; Manara, Renzo; Pepino, Alessandro; Sansone, Mario; Di Salle, Francesco; Esposito, Fabrizio

    2018-04-16

    Cortical surface-based morphometry is based on a semi-automated analysis of structural MRI images. In FreeSurfer, a widespread tool for surface-based analyses, a visual check of gray-white matter borders is followed by the manual placement of control points to drive the topological correction (editing) of segmented data. A novel algorithm combining radial sampling and machine learning is presented for the automated control point search (ACPS). Four data sets with 3 T MRI structural images were used for ACPS validation, including raw data acquired twice in 36 healthy subjects and both raw and FreeSurfer preprocessed data of 125 healthy subjects from public databases. The unedited data from a subgroup of subjects were submitted to manual control point search and editing. The ACPS algorithm was trained on manual control points and tested on new (unseen) unedited data. Cortical thickness (CT) and fractal dimensionality (FD) were estimated in three data sets by reconstructing surfaces from both unedited and edited data, and the effects of editing were compared between manual and automated editing and versus no editing. The ACPS-based editing improved the surface reconstructions similarly to manual editing. Compared to no editing, ACPS-based and manual editing significantly reduced CT and FD in consistent regions across different data sets. Despite the extra processing of control point driven reconstructions, CT and FD estimates were highly reproducible in almost all cortical regions, albeit some problematic regions (e.g. entorhinal cortex) may benefit from different editing. The use of control points improves the surface reconstruction and the ACPS algorithm can automate their search reducing the burden of manual editing. Copyright © 2018 Elsevier Inc. All rights reserved.

  2. Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers.

    PubMed

    Wang, Yumeng; Xu, Xiaoyan; Yu, Shuangxing; Jeong, Kang Jin; Zhou, Zhicheng; Han, Leng; Tsang, Yiu Huen; Li, Jun; Chen, Hu; Mangala, Lingegowda S; Yuan, Yuan; Eterovic, A Karina; Lu, Yiling; Sood, Anil K; Scott, Kenneth L; Mills, Gordon B; Liang, Han

    2017-07-01

    RNA editing, a widespread post-transcriptional mechanism, has emerged as a new player in cancer biology. Recent studies have reported key roles for individual miRNA editing events, but a comprehensive picture of miRNA editing in human cancers remains largely unexplored. Here, we systematically characterized the miRNA editing profiles of 8595 samples across 20 cancer types from miRNA sequencing data of The Cancer Genome Atlas and identified 19 adenosine-to-inosine (A-to-I) RNA editing hotspots. We independently validated 15 of them by perturbation experiments in several cancer cell lines. These miRNA editing events show extensive correlations with key clinical variables (e.g., tumor subtype, disease stage, and patient survival time) and other molecular drivers. Focusing on the RNA editing hotspot in miR-200b, a key tumor metastasis suppressor, we found that the miR-200b editing level correlates with patient prognosis opposite to the pattern observed for the wild-type miR-200b expression. We further experimentally showed that, in contrast to wild-type miRNA, the edited miR-200b can promote cell invasion and migration through its impaired ability to inhibit ZEB1/ZEB2 and acquired concomitant ability to repress new targets, including LIFR , a well-characterized metastasis suppressor. Our study highlights the importance of miRNA editing in gene regulation and suggests its potential as a biomarker for cancer prognosis and therapy. © 2017 Wang et al.; Published by Cold Spring Harbor Laboratory Press.

  3. [CRISPR/CAS9, the King of Genome Editing Tools].

    PubMed

    Bannikov, A V; Lavrov, A V

    2017-01-01

    The discovery of CRISPR/Cas9 brought a hope for having an efficient, reliable, and readily available tool for genome editing. CRISPR/Cas9 is certainly easy to use, while its efficiency and reliability remain the focus of studies. The review describes the general principles of the organization and function of Cas nucleases and a number of important issues to be considered while planning genome editing experiments with CRISPR/Cas9. The issues include evaluation of the efficiency and specificity for Cas9, sgRNA selection, Cas9 variants designed artificially, and use of homologous recombination and nonhomologous end joining in DNA editing.

  4. [Current advances and future prospects of genome editing technology in the field of biomedicine.

    PubMed

    Sakuma, Tetsushi

    Genome editing technology can alter the genomic sequence at will, contributing the creation of cellular and animal models of human diseases including hereditary disorders and cancers, and the generation of the mutation-corrected human induced pluripotent stem cells for ex vivo regenerative medicine. In addition, novel approaches such as drug development using genome-wide CRISPR screening and cancer suppression using epigenome editing technology, which can change the epigenetic modifications in a site-specific manner, have also been conducted. In this article, I summarize the current advances and future prospects of genome editing technology in the field of biomedicine.

  5. Genome Editing of Monogenic Neuromuscular Diseases

    PubMed Central

    Long, Chengzu; Amoasii, Leonela; Bassel-Duby, Rhonda; Olson, Eric N.

    2017-01-01

    IMPORTANCE Muscle weakness, the most common symptom of neuromuscular disease, may result from muscle dysfunction or may be caused indirectly by neuronal and neuromuscular junction abnormalities. To date, more than 780 monogenic neuromuscular diseases, linked to 417 different genes, have been identified in humans. Genome-editing methods, especially the CRISPR (clustered regularly interspaced short palindromic repeats)–Cas9 (CRISPR-associated protein 9) system, hold clinical potential for curing many monogenic disorders, including neuromuscular diseases such as Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1. OBJECTIVES To provide an overview of genome-editing approaches; to summarize published reports on the feasibility, efficacy, and safety of current genome-editing methods as they relate to the potential correction of monogenic neuromuscular diseases; and to highlight scientific and clinical opportunities and obstacles toward permanent correction of disease-causing mutations responsible for monogenic neuromuscular diseases by genome editing. EVIDENCE REVIEW PubMed and Google Scholar were searched for articles published from June 30, 1989, through June 9, 2016, using the following keywords: genome editing, CRISPR-Cas9, neuromuscular disease, Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, andmyotonic dystrophy type 1. The following sources were reviewed: 341 articles describing different approaches to edit mammalian genomes; 330 articles describing CRISPR-Cas9–mediated genome editing in cell culture lines (in vitro) and animal models (in vivo); 16 websites used to generate single-guide RNA; 4 websites for off-target effects; and 382 articles describing viral and nonviral delivery systems. Articles describing neuromuscular diseases, including Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1, were also reviewed. FINDINGS Multiple proof-of-concept studies reveal the feasibility and efficacy of genome-editing–meditated correction of monogenic neuromuscular diseases in cultured cells and animal models. CONCLUSIONS AND RELEVANCE Genome editing is a rapidly evolving technology with enormous translational potential once efficacy, delivery, and safety issues are addressed. The clinical impact of this technology is that genome editing can permanently correct disease-causing mutations and circumvent the hurdles of traditional gene- and cell-based therapies. PMID:27668807

  6. Human Germline Genome Editing.

    PubMed

    Ormond, Kelly E; Mortlock, Douglas P; Scholes, Derek T; Bombard, Yvonne; Brody, Lawrence C; Faucett, W Andrew; Garrison, Nanibaa' A; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E

    2017-08-03

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Genetic Counselors. These groups, as well as the American Society for Reproductive Medicine, Asia Pacific Society of Human Genetics, British Society for Genetic Medicine, Human Genetics Society of Australasia, Professional Society of Genetic Counselors in Asia, and Southern African Society for Human Genetics, endorsed the final statement. The statement includes the following positions. (1) At this time, given the nature and number of unanswered scientific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culminates in human pregnancy. (2) Currently, there is no reason to prohibit in vitro germline genome editing on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research on the possible future clinical applications of gene editing. There should be no prohibition on making public funds available to support this research. (3) Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input. Copyright © 2017 American Society of Human Genetics. All rights reserved.

  7. [Advances in CRISPR-Cas-mediated genome editing system in plants].

    PubMed

    Wang, Chun; Wang, Kejian

    2017-10-25

    Targeted genome editing technology is an important tool to study the function of genes and to modify organisms at the genetic level. Recently, CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) system has emerged as an efficient tool for specific genome editing in animals and plants. CRISPR-Cas system uses CRISPR-associated endonuclease and a guide RNA to generate double-strand breaks at the target DNA site, subsequently leading to genetic modifications. CRISPR-Cas system has received widespread attention for manipulating the genomes with simple, easy and high specificity. This review summarizes recent advances of diverse applications of the CRISPR-Cas toolkit in plant research and crop breeding, including expanding the range of genome editing, precise editing of a target base, and efficient DNA-free genome editing technology. This review also discusses the potential challenges and application prospect in the future, and provides a useful reference for researchers who are interested in this field.

  8. A Subdivision-Based Representation for Vector Image Editing.

    PubMed

    Liao, Zicheng; Hoppe, Hugues; Forsyth, David; Yu, Yizhou

    2012-11-01

    Vector graphics has been employed in a wide variety of applications due to its scalability and editability. Editability is a high priority for artists and designers who wish to produce vector-based graphical content with user interaction. In this paper, we introduce a new vector image representation based on piecewise smooth subdivision surfaces, which is a simple, unified and flexible framework that supports a variety of operations, including shape editing, color editing, image stylization, and vector image processing. These operations effectively create novel vector graphics by reusing and altering existing image vectorization results. Because image vectorization yields an abstraction of the original raster image, controlling the level of detail of this abstraction is highly desirable. To this end, we design a feature-oriented vector image pyramid that offers multiple levels of abstraction simultaneously. Our new vector image representation can be rasterized efficiently using GPU-accelerated subdivision. Experiments indicate that our vector image representation achieves high visual quality and better supports editing operations than existing representations.

  9. The LHEA PDP 11/70 graphics processing facility users guide

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A compilation of all necessary and useful information needed to allow the inexperienced user to program on the PDP 11/70. Information regarding the use of editing and file manipulation utilities as well as operational procedures are included. The inexperienced user is taken through the process of creating, editing, compiling, task building and debugging his/her FORTRAN program. Also, documentation on additional software is included.

  10. The clinical applications of genome editing in HIV.

    PubMed

    Wang, Cathy X; Cannon, Paula M

    2016-05-26

    HIV/AIDS has long been at the forefront of the development of gene- and cell-based therapies. Although conventional gene therapy approaches typically involve the addition of anti-HIV genes to cells using semirandomly integrating viral vectors, newer genome editing technologies based on engineered nucleases are now allowing more precise genetic manipulations. The possible outcomes of genome editing include gene disruption, which has been most notably applied to the CCR5 coreceptor gene, or the introduction of small mutations or larger whole gene cassette insertions at a targeted locus. Disruption of CCR5 using zinc finger nucleases was the first-in-human application of genome editing and remains the most clinically advanced platform, with 7 completed or ongoing clinical trials in T cells and hematopoietic stem/progenitor cells (HSPCs). Here we review the laboratory and clinical findings of CCR5 editing in T cells and HSPCs for HIV therapy and summarize other promising genome editing approaches for future clinical development. In particular, recent advances in the delivery of genome editing reagents and the demonstration of highly efficient homology-directed editing in both T cells and HSPCs are expected to spur the development of even more sophisticated applications of this technology for HIV therapy. © 2016 by The American Society of Hematology.

  11. School Safety. Communique Special Edition, Fall 1996.

    ERIC Educational Resources Information Center

    National Association of School Psychologists, Washington, DC.

    "Communique" is the "official newsletter of the National Association of School Psychologists" (NASP). This "Special Edition" of "Communique" is a compilation of twelve previously-published articles/pieces all of which touch on the theme of "School Safety." Articles in this issue include (1)…

  12. Prognostic value of the 8th edition of the tumor-node-metastasis classification for patients with papillary thyroid carcinoma: a single-institution study at a high-volume center in Japan.

    PubMed

    Ito, Yasuhiro; Miyauchi, Akira; Hirokawa, Mitsuyoshi; Yamamoto, Masatoshi; Oda, Hitomi; Masuoka, Hiroo; Sasai, Hisanori; Fukushima, Mitsuhiro; Higashiyama, Takuya; Kihara, Minoru; Miya, Akihiro

    2018-04-20

    The tumor-node-metastasis (TNM) staging system is most commonly adopted to evaluate the prognosis of patients with thyroid carcinoma. The 8 th edition of the TNM staging system, an extensively revised version of the 7 th edition, was recently released. We aimed to investigate whether and how well the 8 th edition reflects the cause-specific survival (CSS) of patients with papillary thyroid carcinoma by analyzing the cases in 5,892 patients who underwent initial surgery at Kuma Hospital between 1987 and 2005. The median postoperative follow-up duration was 178 months (range: 6-357 months). One patient with T4b disease was excluded from the analysis. Overall, 116 (2.0%) patients died of thyroid carcinoma. The proportion of variance explained (PVE) for CSS in the 7 th and 8 th editions was 10.69 and 10.97, respectively. Using the 7 th edition, CSS of patients with stage IVA and stage III disease was similar (p = 0.32). In contrast, using the 8 th edition, CSS was poorer in stage II than in stage I (p < 0.001), in stage III than in stage II (p < 0.001), and in stage IVB than in stage III (p < 0.001). Similar results were observed for disease-free survival. Although we could not establish any objective evidence that the 8 th edition is superior to the 7 th edition, the 8 th edition is simpler and more convenient, as it includes fewer stages and addresses the issue of the 7 th edition where stage IVA and III patients had similar prognoses.

  13. Systematic assessment of the representativeness of published collections of the traditional literature on Chinese medicine.

    PubMed

    May, Brian H; Lu, Yubo; Lu, Chuanjian; Zhang, Anthony L; Chang, Suyueh; Xue, Charlie C L

    2013-05-01

    The traditional Chinese medical literature provides a substantial resource for natural products research. When undertaking systematic searches, investigators need to assess the scope, content, and relevance of collections both singly and in comparison. This study examines eight collections of pre-modern literature, develops an approach to quantitatively assess their content, and compares their relative inclusivity. All publications listed in each collection were collated and a uniform scoring system was developed to account for variant editions, incorporation of multiple books under a single title, addition of commentaries, and other factors affecting content. Comparisons were undertaken between collections to determine the degree of overlap, genres of literature represented, and relevance to natural products research. Following adjustments for differences in how books were listed, duplications, and variant editions, Zhong Hua Yi Dian (Encyclopaedia of Traditional Chinese Medicine) (4th edition CD) is the largest collection of complete books containing 1009 different books. Zhong Guo Ben Cao Quan Shu (The Complete Collection of Traditional Texts on Chinese Materia Medica) contains 2026 titles including multiple editions and extracts, so after adjustments the number of different complete books is approximately 740. No collection was fully inclusive of the others, but Zhong Hua Yi Dian includes between 52.1% and 91.5% of the books in the six smaller collections. Comparing traditional collections is complex due to variant editions and multiple titles. This necessitates examination of the text rather than title alone. Prior to undertaking systematic searches, the characteristics of collections need to be investigated, duplicated books identified, and differences between editions should be assessed. Its size, electronic format, and broad spread of genres makes Zhong Hua Yi Dian suitable for systematic searches, but due to the lack of bibliographical detail on included books, cross-referencing to other collections is recommended.

  14. Genome editing comes of age.

    PubMed

    Kim, Jin-Soo

    2016-09-01

    Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field.

  15. A-to-I RNA editing promotes developmental stage–specific gene and lncRNA expression

    PubMed Central

    Goldstein, Boaz; Agranat-Tamir, Lily; Light, Dean; Ben-Naim Zgayer, Orna; Fishman, Alla; Lamm, Ayelet T.

    2017-01-01

    A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) is converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded RNA regions, mainly noncoding. Mutations in ADAR enzymes in Caenorhabditis elegans cause defects in normal development but are not lethal as in human and mouse. Previous studies in C. elegans indicated competition between RNA interference (RNAi) and RNA editing mechanisms, based on the observation that worms that lack both mechanisms do not exhibit defects, in contrast to the developmental defects observed when only RNA editing is absent. To study the effects of RNA editing on gene expression and function, we established a novel screen that enabled us to identify thousands of RNA editing sites in nonrepetitive regions in the genome. These include dozens of genes that are edited at their 3′ UTR region. We found that these genes are mainly germline and neuronal genes, and that they are down-regulated in the absence of ADAR enzymes. Moreover, we discovered that almost half of these genes are edited in a developmental-specific manner, indicating that RNA editing is a highly regulated process. We found that many pseudogenes and other lncRNAs are also extensively down-regulated in the absence of ADARs in the embryo but not in the fourth larval (L4) stage. This down-regulation is not observed upon additional knockout of RNAi. Furthermore, levels of siRNAs aligned to pseudogenes in ADAR mutants are enhanced. Taken together, our results suggest a role for RNA editing in normal growth and development by regulating silencing via RNAi. PMID:28031250

  16. Geophysical methods in Geology. Second edition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sharma, P.V.

    This book presents an introduction to the methods of geophysics and their application to geological problems. The text emphasizes the broader aspects of geophysics, including the way in which geophysical methods help solve structural, correlational, and geochromological problems. Stress is laid on the principles and applications of methods rather than on instrumental techniques. This edition includes coverage of recent developments in geophysics and geology. New topics are introduced, including paleomagnetic methods, electromagnetic methods, microplate tectronics, and the use of multiple geophysical techniques.

  17. Therapeutic gene editing: delivery and regulatory perspectives.

    PubMed

    Shim, Gayong; Kim, Dongyoon; Park, Gyu Thae; Jin, Hyerim; Suh, Soo-Kyung; Oh, Yu-Kyoung

    2017-06-01

    Gene-editing technology is an emerging therapeutic modality for manipulating the eukaryotic genome by using target-sequence-specific engineered nucleases. Because of the exceptional advantages that gene-editing technology offers in facilitating the accurate correction of sequences in a genome, gene editing-based therapy is being aggressively developed as a next-generation therapeutic approach to treat a wide range of diseases. However, strategies for precise engineering and delivery of gene-editing nucleases, including zinc finger nucleases, transcription activator-like effector nuclease, and CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated nuclease Cas9), present major obstacles to the development of gene-editing therapies, as with other gene-targeting therapeutics. Currently, viral and non-viral vectors are being studied for the delivery of these nucleases into cells in the form of DNA, mRNA, or proteins. Clinical trials are already ongoing, and in vivo studies are actively investigating the applicability of CRISPR/Cas9 techniques. However, the concept of correcting the genome poses major concerns from a regulatory perspective, especially in terms of safety. This review addresses current research trends and delivery strategies for gene editing-based therapeutics in non-clinical and clinical settings and considers the associated regulatory issues.

  18. Editing the human genome: where ART and science intersect.

    PubMed

    Hershlag, Avner; Bristow, Sara L

    2018-06-07

    The rapid development of gene-editing technologies has led to an exponential rise in both basic and translational research initiatives studying molecular processes and investigating possible clinical applications. Early experiments using genome editing to study human embryo development have contradicted findings in studies on model organisms. Additionally, a series of four experiments over the past 2 years set out to investigate the possibilities of introducing genetic modifications to human embryos, each with varying levels of success. Here, we discuss the key findings of these studies, including the efficiency, the safety, the potential untoward effects, major flaws of the studies, and emerging alternative genome editing methods that may allow overcoming the hurdles encountered so far. Given these results, we also raise several questions about the clinical utilization of germline gene editing: For which indications is gene editing appropriate? How do gene-editing technologies compare with genetic testing methods currently used for screening embryos? What are the ethical considerations we should be concerned about? While further research is underway, and our understanding of how to implement this technology continues to evolve, it is critical to contemplate if and how it should be translated from the bench to clinical practice.

  19. Publication Manual of the American Psychological Association--5th edition: a review of additions and changes in style requirements.

    PubMed

    Russell, Cynthia L; Aud, Myra A

    2002-01-01

    The purpose of this article is to highlight the substantive changes and enhancements between the 4th edition and new 5th edition of the so that modifications and enhancements are more easily incorporated into the reader's writing and editing practice. The 4th and new 5th editions of the were compared and substantive changes are presented. The following text style requirements are addressed: (a) use of parentheses to enclose statistical values, (b) use of italics, and (c) presentation of statistical data. Reference citation style changes include: (a) use of italics instead of underlining, (b) use of et al., and (c) use of the hanging indent. With the explosion of electronic media use, guidelines for documenting these sources are reviewed. Appropriate use of adverbs and research subject descriptors, submission of manuscripts on disks or files, responsibilities of corresponding authors, and converting the dissertation into a journal article are addressed. This information should assist the reader to quickly and accurately focus upon the enhancements and changes in the recently released 5th edition. Hopefully these changes will easily be incorporated into the readers' editing responsibilities, manuscripts, and subsequent publications.

  20. Therapeutic gene editing: delivery and regulatory perspectives

    PubMed Central

    Shim, Gayong; Kim, Dongyoon; Park, Gyu Thae; Jin, Hyerim; Suh, Soo-Kyung; Oh, Yu-Kyoung

    2017-01-01

    Gene-editing technology is an emerging therapeutic modality for manipulating the eukaryotic genome by using target-sequence-specific engineered nucleases. Because of the exceptional advantages that gene-editing technology offers in facilitating the accurate correction of sequences in a genome, gene editing-based therapy is being aggressively developed as a next-generation therapeutic approach to treat a wide range of diseases. However, strategies for precise engineering and delivery of gene-editing nucleases, including zinc finger nucleases, transcription activator-like effector nuclease, and CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated nuclease Cas9), present major obstacles to the development of gene-editing therapies, as with other gene-targeting therapeutics. Currently, viral and non-viral vectors are being studied for the delivery of these nucleases into cells in the form of DNA, mRNA, or proteins. Clinical trials are already ongoing, and in vivo studies are actively investigating the applicability of CRISPR/Cas9 techniques. However, the concept of correcting the genome poses major concerns from a regulatory perspective, especially in terms of safety. This review addresses current research trends and delivery strategies for gene editing-based therapeutics in non-clinical and clinical settings and considers the associated regulatory issues. PMID:28392568

  1. Mass Media and Communication. Second, Revised Edition.

    ERIC Educational Resources Information Center

    Steinberg, Charles S., Ed.

    This revised and enlarged second edition contains sections focusing on a number of mass media: newspapers, the American magazine, motion pictures, broadcasting media, and book publishing. Other section topics include the structure and development of mass communication, public opinion, international communication, the motivation of assent, the…

  2. Healthy People 2010: Conference Edition, Volume I [and] Volume II.

    ERIC Educational Resources Information Center

    Department of Health and Human Services, Washington, DC.

    This document contains the two volumes of the Conference Edition of Healthy People 2010, a comprehensive, nationwide health promotion and disease prevention agenda. The first section of Volume I, "Healthy People 2010: Understanding and Improving Health," includes "Introduction,""Leading Health Indicators," and…

  3. ETC 408/508: Technical Editing

    ERIC Educational Resources Information Center

    Charlton, Michael

    2013-01-01

    The course will focus on the role of the editor in organizational settings, including creating successful writer/editor collaboration. Students will gain practice in editing documents for grammar, syntax, organization, style, emphasis, document design, graphics, and user-centered design. The course will provide an introduction to technology for…

  4. A Review of Assessment Tools for Diagnosis of Autism Spectrum Disorders: Implications for School Practice

    ERIC Educational Resources Information Center

    Klose, Laurie McGarry; Plotts, Cynthia; Kozeneski, Nicole; Skinner-Foster, Jacqueline

    2012-01-01

    This paper provides a review of widely used measures for assessing Autism Spectrum Disorders, including the "Autism Diagnostic Interview-Revised," "Autism Diagnostic Observation Schedule," "Psychoeducational Profile-Third Edition," "Gilliam Autism Rating Scale-Second Edition," and "Childhood Autism…

  5. Planning and Producing Audiovisual Materials. Third Edition.

    ERIC Educational Resources Information Center

    Kemp, Jerrold E.

    A revised edition of this handbook provides illustrated, step-by-step explanations of how to plan and produce audiovisual materials. Included are sections on the fundamental skills--photography, graphics and recording sound--followed by individual sections on photographic print series, slide series, filmstrips, tape recordings, overhead…

  6. What Comics Do When They Do It Right: An Interview with Art Spiegelman.

    ERIC Educational Resources Information Center

    Goldsmith, Francisca

    2002-01-01

    Relates a telephone interview with graphic novelist Art Spiegelman that discusses his career choice; comics for young children; editing comics; the different perspective on comics in France, including hardcover editions; and reviewers and how they address form and content. (LRW)

  7. Beyond the Anchor: Students and Broadcasting Opportunities.

    ERIC Educational Resources Information Center

    Marks, Rick

    1999-01-01

    Describes how the author taught a class (called "Editing for Broadcasting") for 19 neophyte newspeople through total immersion: students learned how to run a newsroom while operating one. Notes that students learned the principles and fundamentals of broadcast journalism, including news judgment, writing, editing, reporting, and…

  8. Handbook of Qualitative Research. Second Edition.

    ERIC Educational Resources Information Center

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    This handbook's second edition represents the state of the art for the theory and practice of qualitative inquiry. It features eight new topics, including autoethnography, critical race theory, applied ethnography, queer theory, and "testimonio"every chapter in the handbook has been thoroughly revised and updated. The book…

  9. Massive Gene Transfer and Extensive RNA Editing of a Symbiotic Dinoflagellate Plastid Genome

    PubMed Central

    Mungpakdee, Sutada; Shinzato, Chuya; Takeuchi, Takeshi; Kawashima, Takeshi; Koyanagi, Ryo; Hisata, Kanako; Tanaka, Makiko; Goto, Hiroki; Fujie, Manabu; Lin, Senjie; Satoh, Nori; Shoguchi, Eiichi

    2014-01-01

    Genome sequencing of Symbiodinium minutum revealed that 95 of 109 plastid-associated genes have been transferred to the nuclear genome and subsequently expanded by gene duplication. Only 14 genes remain in plastids and occur as DNA minicircles. Each minicircle (1.8–3.3 kb) contains one gene and a conserved noncoding region containing putative promoters and RNA-binding sites. Nine types of RNA editing, including a novel G/U type, were discovered in minicircle transcripts but not in genes transferred to the nucleus. In contrast to DNA editing sites in dinoflagellate mitochondria, which tend to be highly conserved across all taxa, editing sites employed in DNA minicircles are highly variable from species to species. Editing is crucial for core photosystem protein function. It restores evolutionarily conserved amino acids and increases peptidyl hydropathy. It also increases protein plasticity necessary to initiate photosystem complex assembly. PMID:24881086

  10. Salient Features of Endonuclease Platforms for Therapeutic Genome Editing.

    PubMed

    Certo, Michael T; Morgan, Richard A

    2016-03-01

    Emerging gene-editing technologies are nearing a revolutionary phase in genetic medicine: precisely modifying or repairing causal genetic defects. This may include any number of DNA sequence manipulations, such as knocking out a deleterious gene, introducing a particular mutation, or directly repairing a defective sequence by site-specific recombination. All of these edits can currently be achieved via programmable rare-cutting endonucleases to create targeted DNA breaks that can engage and exploit endogenous DNA repair pathways to impart site-specific genetic changes. Over the past decade, several distinct technologies for introducing site-specific DNA breaks have been developed, yet the different biological origins of these gene-editing technologies bring along inherent differences in parameters that impact clinical implementation. This review aims to provide an accessible overview of the various endonuclease-based gene-editing platforms, highlighting the strengths and weakness of each with respect to therapeutic applications.

  11. Salient Features of Endonuclease Platforms for Therapeutic Genome Editing

    PubMed Central

    Certo, Michael T; Morgan, Richard A

    2016-01-01

    Emerging gene-editing technologies are nearing a revolutionary phase in genetic medicine: precisely modifying or repairing causal genetic defects. This may include any number of DNA sequence manipulations, such as knocking out a deleterious gene, introducing a particular mutation, or directly repairing a defective sequence by site-specific recombination. All of these edits can currently be achieved via programmable rare-cutting endonucleases to create targeted DNA breaks that can engage and exploit endogenous DNA repair pathways to impart site-specific genetic changes. Over the past decade, several distinct technologies for introducing site-specific DNA breaks have been developed, yet the different biological origins of these gene-editing technologies bring along inherent differences in parameters that impact clinical implementation. This review aims to provide an accessible overview of the various endonuclease-based gene-editing platforms, highlighting the strengths and weakness of each with respect to therapeutic applications. PMID:26796671

  12. From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing.

    PubMed

    Hotta, Akitsu; Yamanaka, Shinya

    2015-01-01

    The advent of induced pluripotent stem (iPS) cells has opened up numerous avenues of opportunity for cell therapy, including the initiation in September 2014 of the first human clinical trial to treat dry age-related macular degeneration. In parallel, advances in genome-editing technologies by site-specific nucleases have dramatically improved our ability to edit endogenous genomic sequences at targeted sites of interest. In fact, clinical trials have already begun to implement this technology to control HIV infection. Genome editing in iPS cells is a powerful tool and enables researchers to investigate the intricacies of the human genome in a dish. In the near future, the groundwork laid by such an approach may expand the possibilities of gene therapy for treating congenital disorders. In this review, we summarize the exciting progress being made in the utilization of genomic editing technologies in pluripotent stem cells and discuss remaining challenges toward gene therapy applications.

  13. Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9.

    PubMed

    Everman, Jamie L; Rios, Cydney; Seibold, Max A

    2018-01-01

    The adaptation of the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated endonuclease 9 (CRISPR-Cas9) machinery from prokaryotic organisms has resulted in a gene editing system that is highly versatile, easily constructed, and can be leveraged to generate human cells knocked out (KO) for a specific gene. While standard transfection techniques can be used for the introduction of CRISPR-Cas9 expression cassettes to many cell types, delivery by this method is not efficient in many primary cell types, including primary human airway epithelial cells (AECs). More efficient delivery in AECs can be achieved through lentiviral-mediated transduction, allowing the CRISPR-Cas9 system to be integrated into the genome of the cell, resulting in stable expression of the nuclease machinery and increasing editing rates. In parallel, advancements have been made in the culture, expansion, selection, and differentiation of AECs, which allow the robust generation of a bulk edited AEC population from transduced cells. Applying these methods, we detail here our latest protocol to generate mucociliary epithelial cultures knocked out for a specific gene from donor-isolated primary human basal airway epithelial cells. This protocol includes methods to: (1) design and generate lentivirus which targets a specific gene for KO with CRISPR-Cas9 machinery, (2) efficiently transduce AECs, (3) culture and select for a bulk edited AEC population, (4) molecularly screen AECs for Cas9 cutting and specific sequence edits, and (5) further expand and differentiate edited cells to a mucociliary airway epithelial culture. The AEC knockouts generated using this protocol provide an excellent primary cell model system with which to characterize the function of genes involved in airway dysfunction and disease.

  14. Naval Observatory Vector Astrometry Software (NOVAS) Version 3.1:Fortran, C, and Python Editions

    NASA Astrophysics Data System (ADS)

    Kaplan, G. H.; Bangert, J. A.; Barron, E. G.; Bartlett, J. L.; Puatua, W.; Harris, W.; Barrett, P.

    2012-08-01

    The Naval Observatory Vector Astrometry Software (NOVAS) is a source - code library that provides common astrometric quantities and transformations to high precision. The library can supply, in one or two subroutine or function calls, the instantaneous celestial position of any star or planet in a variety of coordinate systems. NOVAS also provides access to all of the building blocks that go into such computations. NOVAS is used for a wide variety of applications, including the U.S. portions of The Astronomical Almanac and a number of telescope control systems. NOVAS uses IAU recommended models for Earth orientation, including the IAU 2006 precession theory, the IAU 2000A and 2000B nutation series, and diurnal rotation based on the celestial and terrestrial intermediate origins. Equinox - based quantities, such as sidereal time, are also supported. NOVAS Earth orientation calculations match those from SOFA at the sub - microarcsecond level for comparable transformations. NOVAS algorithms for aberration an d gravitational light deflection are equivalent, at the microarcsecond level, to those inherent in the current consensus VLBI delay algorithm. NOVAS can be easily connected to the JPL planetary/lunar ephemerides (e.g., DE405), and connections to IMCCE and IAA planetary ephemerides are planned. NOVAS Version 3.1 introduces a Python edition alongside the Fortran and C editions. The Python edition uses the computational code from the C edition and currently mimics the function calls of the C edition. Future versions will expand the functionality of the Python edition to exploit the object - oriented features of Python. In the Version 3.1 C edition, the ephemeris - access functions have been revised for use on 64 - bit systems and for improved performance in general. NOVAS source code, auxiliary files, and documentation are available from the USNO website (http://aa.usno.navy.mil/software/novas/novas_info.php).

  15. The changing landscape of gene editing in hematopoietic stem cells: a step towards Cas9 clinical translation.

    PubMed

    Dever, Daniel P; Porteus, Matthew H

    2017-11-01

    Since the discovery two decades ago that programmable endonucleases can be engineered to modify human cells at single nucleotide resolution, the concept of genome editing was born. Now these technologies are being applied to therapeutically relevant cell types, including hematopoietic stem cells (HSC), which possess the power to repopulate an entire blood and immune system. The purpose of this review is to discuss the changing landscape of genome editing in hematopoietic stem cells (GE-HSC) from the discovery stage to the preclinical stage, with the imminent goal of clinical translation for the treatment of serious genetic diseases of the blood and immune system. With the discovery that the RNA-programmable (sgRNA) clustered regularly interspace short palindromic repeats (CRISPR)-Cas9 nuclease (Cas9/sgRNA) systems can be easily used to precisely modify the human genome in 2012, a genome-editing revolution of hematopoietic stem cells (HSC) has bloomed. We have observed that over the last 2 years, academic institutions and small biotech companies are developing HSC-based Cas9/sgRNA genome-editing curative strategies to treat monogenic disorders, including β-hemoglobinopathies and primary immunodeficiencies. We will focus on recent publications (within the past 2 years) that employ different genome-editing strategies to 'hijack' the cell's endogenous double-strand repair pathways to confer a disease-specific therapeutic advantage. The number of genome-editing strategies in HSCs that could offer therapeutic potential for diseases of the blood and immune system have dramatically risen over the past 2 years. The HSC-based genome-editing field is primed to enter clinical trials in the subsequent years. We will summarize the major advancements for the development of novel autologous GE-HSC cell and gene therapy strategies for hematopoietic diseases that are candidates for curative allogeneic bone marrow transplantation.

  16. NASA's participation in the AVE-SESAME '79 program

    NASA Technical Reports Server (NTRS)

    Hill, K.; Turner, R. E.; Wilson, G. S.

    1979-01-01

    NASA's Marshall Space Flight Center participated with its AVE (Atmospheric Variability Experiment) in a large interagency mesoscale and severe storms experiment identified herein as AVE-SESAME '79 (Atmospheric Variability Experiment-Severe Environmental Storms and Mesoscale Experiment 1979). A primary objective of NASA was to support an effort to acquire carefully edited sets of rawinsonde data during selected severe weather events for use in correlative and diagnostic studies with satellite and radar data obtained at approximately the same times. Data were acquired during six individual 24-h experiments on both the regional and storm scales over a network in the central United States that utilized approximately 20 supplemental rawinsonde sites meshed among 23 standard National Weather Service sites. Included among the six experiments are data obtained between 1200 GMT on April 10 and 1200 GMT on April 11, encompassing the formation and development period for the tornado-producing systems that devastated Wichita Falls, Texas, and other sections of Oklahoma and Texas. The other dates for which data sets are available are April 19-20 and 25-26, May 9-10 and 20-21, and June 7-8, 1979.

  17. An improved immune algorithm for optimizing the pulse width modulation control sequence of inverters

    NASA Astrophysics Data System (ADS)

    Sheng, L.; Qian, S. Q.; Ye, Y. Q.; Wu, Y. H.

    2017-09-01

    In this article, an improved immune algorithm (IIA), based on the fundamental principles of the biological immune system, is proposed for optimizing the pulse width modulation (PWM) control sequence of a single-phase full-bridge inverter. The IIA takes advantage of the receptor editing and adaptive mutation mechanisms of the immune system to develop two operations that enhance the population diversity and convergence of the proposed algorithm. To verify the effectiveness and examine the performance of the IIA, 17 cases are considered, including fixed and disturbed resistances. Simulation results show that the IIA is able to obtain an effective PWM control sequence. Furthermore, when compared with existing immune algorithms (IAs), genetic algorithms (GAs), a non-traditional GA, simplified simulated annealing, and a generalized Hopfield neural network method, the IIA can achieve small total harmonic distortion (THD) and large magnitude. Meanwhile, a non-parametric test indicates that the IIA is significantly better than most comparison algorithms. Supplemental data for this article can be accessed at http://dx.doi.org/10.1080/0305215X.2016.1250894.

  18. Staging of intrahepatic cholangiocarcinoma

    PubMed Central

    Ronnekleiv-Kelly, Sean M.

    2017-01-01

    Intrahepatic cholangiocarcinoma (ICC) comprises approximately 5−30% of primary liver tumors, however it has been increasing over the last several decades. Up to and including the 6th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) edition staging system, ICC was staged the same as hepatocellular carcinoma. In the 7th edition AJCC/UICC manual, the staging system of ICC was revised such that a distinct classification was proposed. Pathologic features for prognosis included vascular invasion, tumor multiplicity, local extension, periductal infiltration and lymph nodal metastasis. Over the last decade, as the incidence of ICC has increased and surgery for this indication has become more common, more data has been published on the prognostic factors associated with long-term survival. PMID:28261593

  19. 37 CFR 201.40 - Exemption to prohibition against circumvention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... by the operator of the network. (4) Video games accessible on personal computers and protected by... copyright infringement or a violation of applicable law. (5) Computer programs protected by dongles that... editions of the work (including digital text editions made available by authorized entities) contain access...

  20. Recommended Reference Books in Paperback. Third Edition.

    ERIC Educational Resources Information Center

    Lang, Jovian P.; O'Gorman, Jack

    Completely revised and updated from the last edition (1992), this annotated, evaluative bibliography presents more than 1,000 outstanding titles chosen for their quality, economy, and availability. Thirty-six chapters describe and judge these affordable paperbacks for libraries with limited budgets. Subject matter includes: general reference, area…

  1. Section 619 Profile, 19th Edition

    ERIC Educational Resources Information Center

    Lazara, A., Ed.; Danaher, J., Ed.; Kraus, R., Ed.; Goode, S., Ed.; Hipps, C., Ed.; Festa, C., Ed.

    2012-01-01

    This 2012 edition of this publication updates information provided by state coordinators on state policies, programs, and practices under the Preschool Grants Program (Section 619 of Part B) of the Individuals with Disabilities Education Act (IDEA). Information includes: (1) program administration; (2) funding; (3) interagency coordination; (4)…

  2. Teaching Reading Sourcebook, Second Edition

    ERIC Educational Resources Information Center

    Honig, Bill; Diamond, Linda; Gutlohn, Linda

    2008-01-01

    The "Teaching Reading Sourcebook, Second Edition" is a comprehensive reference about reading instruction. Organized according to the elements of explicit instruction (what? why? when? and how?), the "Sourcebook" includes both a research-informed knowledge base and practical sample lesson models. It teaches the key elements of an effective reading…

  3. Introduction to Educational Leadership and Organizational Behavior: Theory into Practice. Second Edition

    ERIC Educational Resources Information Center

    Chance, Patti L.

    2009-01-01

    Like the bestselling first edition, this introductory textbook succinctly presents concepts and theories of educational leadership and organizational behavior and immediately applies them to problems of practice. It includes practical case studies, real-world scenarios and analyses, reflection questions, and straightforward explanations of…

  4. Cognitive Psychology and Instruction. Third Edition.

    ERIC Educational Resources Information Center

    Bruning, Roger H.; Schraw, Gregory J.; Ronning, Royce R.

    Like the earlier editions, the current text is directed at educators who are interested in understanding the principles of cognitive psychology and applying them to instruction and curriculum design. The following chapters are included: (1) "Introduction to Cognitive Psychology"; (2) "Sensory, Short-Term, and Working Memory"; (3) "Long-Term…

  5. The development of a research agenda for substance use disorders diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V).

    PubMed

    Saunders, John B; Schuckit, Marc A

    2006-09-01

    This paper describes the background to the establishment of the Substance Use Disorders Workgroup, which was charged with developing the research agenda for the development of the next edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). It summarizes 18 articles that were commissioned to inform that process. A preliminary list of research topics, developed at the DSM-V Launch Conference in 2004, led to the identification of subjects that were subject to formal presentations and detailed discussion at the Substance Use Disorders Conference in February 2005. The 18 articles presented in this supplement examine: (1) categorical versus dimensional diagnoses; (2) the neurobiological basis of substance use disorders; (3) social and cultural perspectives; (4) the crosswalk between DSM-IV and the International Classification of Diseases Tenth Revision (ICD-10); (5) comorbidity of substance use disorders and mental health disorders; (6) subtypes of disorders; (7) issues in adolescence; (8) substance-specific criteria; (9) the place of non-substance addictive disorders; and (10) the available research resources. In the final paper a broadly based research agenda for the development of diagnostic concepts and criteria for substance use disorders is presented.

  6. Quagga and zebra mussels: biology, impacts, and control

    USGS Publications Warehouse

    Nalepa, Thomas F.; Schloesser, Don W.; Nalepa, Thomas F.; Schloesser, Don W.

    2013-01-01

    Quagga and Zebra Mussels: Biology, Impacts, and Control, Second Edition provides a broad view of the zebra/quagga mussel issue, offering a historic perspective and up-to-date information on mussel research. Comprising 48 chapters, this second edition includes reviews of mussel morphology, physiology, and behavior. It details mussel distribution and spread in Europe and across North America, and examines policy and regulatory responses, management strategies, and mitigation efforts. In addition, this book provides extensive coverage of the impact of invasive mussel species on freshwater ecosystems, including effects on water clarity, phytoplankton, water quality, food web changes, and consequences to other aquatic fauna. It also reviews and offers new insights on how zebra and quagga mussels respond and adapt to varying environmental conditions. This new edition includes seven video clips that complement chapter text and, through visual documentation, provide a greater understanding of mussel behavior and distribution.

  7. A-to-I RNA editing promotes developmental stage-specific gene and lncRNA expression.

    PubMed

    Goldstein, Boaz; Agranat-Tamir, Lily; Light, Dean; Ben-Naim Zgayer, Orna; Fishman, Alla; Lamm, Ayelet T

    2017-03-01

    A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) is converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded RNA regions, mainly noncoding. Mutations in ADAR enzymes in Caenorhabditis elegans cause defects in normal development but are not lethal as in human and mouse. Previous studies in C. elegans indicated competition between RNA interference (RNAi) and RNA editing mechanisms, based on the observation that worms that lack both mechanisms do not exhibit defects, in contrast to the developmental defects observed when only RNA editing is absent. To study the effects of RNA editing on gene expression and function, we established a novel screen that enabled us to identify thousands of RNA editing sites in nonrepetitive regions in the genome. These include dozens of genes that are edited at their 3' UTR region. We found that these genes are mainly germline and neuronal genes, and that they are down-regulated in the absence of ADAR enzymes. Moreover, we discovered that almost half of these genes are edited in a developmental-specific manner, indicating that RNA editing is a highly regulated process. We found that many pseudogenes and other lncRNAs are also extensively down-regulated in the absence of ADARs in the embryo but not in the fourth larval (L4) stage. This down-regulation is not observed upon additional knockout of RNAi. Furthermore, levels of siRNAs aligned to pseudogenes in ADAR mutants are enhanced. Taken together, our results suggest a role for RNA editing in normal growth and development by regulating silencing via RNAi. © 2017 Goldstein et al.; Published by Cold Spring Harbor Laboratory Press.

  8. E-mail to Promote Colorectal Cancer Screening Within Social Networks: Acceptability and Content

    PubMed Central

    CUTRONA, SARAH L.; WAGNER, JOANN; ROBLIN, DOUGLAS W.; GAGLIO, BRIDGET; WILLIAMS, ANDREW; TORRES-STONE, ROSALIE; MAZOR, KATHLEEN M.

    2016-01-01

    Effective techniques to encourage colorectal cancer (CRC) screening in underscreened populations have included social support interventions and email reminders from physicians. Personalized email messages to promote CRC screening within social networks could be even more effective, but have not been studied. We interviewed 387 email users, aged 42-73 years in Massachusetts, Hawaii, and Georgia. Participants were asked to edit a sample message in which the sender shares a recent colonoscopy experience and urges the recipient to discuss CRC screening with a doctor. For those reporting willingness to send this message, changes to the message and suggested subject lines were recorded. Edited text was analyzed for content and concordance with original message. The majority of participants (74.4%) were willing to email a modifiable message. Of those willing, 63.5% edited the message. Common edits included deletion (17.7%) or modification (17.4%) of a negatively framed sentence on colon cancer risks and addition or modification of personalizing words (15.6%). Few edits changed the meaning of the message (5.6%) and even fewer introduced factual inaccuracies (1.7%). Modifiable email messages offer a way for screened individuals to promote CRC screening to social network members. Accuracy and impact of such messages should be further studied. PMID:25839968

  9. The Fifth Edition of the APA "Publication Manual": Why Its Statistics Recommendations Are So Controversial.

    ERIC Educational Resources Information Center

    Fidler, Fiona

    2002-01-01

    Identifies deficiencies in the new edition of the American Psychological Association's "Publication Manual," drawing on interviews with some critics and other parties. These include lack of follow-through with explanations and examples of how to report the statistics now recommended. (SLD)

  10. Career Choice and Development. Third Edition.

    ERIC Educational Resources Information Center

    Brown, Duane; And Others

    This book contains 12 papers examining established and newly emerging theories of career choice and development. Following prefaces to the third, second, and first editions by Duane Brown and Linda Brooks, the following papers are included: "Introduction to Theories of Career Development and Choice: Origins, Evolution, and Current Efforts" (Duane…

  11. Food Production, Management and Services: Service. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Palan, Earl

    This food production, management, and services teacher guide contains nine units: (1) orientation; (2) types of service; (3) table settings; (4) dining room personnel; (5) dining room procedures; (6) side work; (7) guest/employee relationships; (8) sales techniques; and (9) safety and sanitation. Suggestions are included to increase reinforcement…

  12. Outdoor Biology Instructional Strategies Trial Edition. Set I.

    ERIC Educational Resources Information Center

    Fairwell, Kay, Ed.; And Others

    The Outdoor Biology Instructional Strategies (OBIS) Trial Edition Set I contains 24 varied activities which make use of crafts, simulations, and basic investigative techniques to provide introductory learning experiences in outdoor biology for children aged 10 to 15. The individual water-resistant folio for each activity includes biological…

  13. Improving Science Education and Understanding through Editing Wikipedia

    ERIC Educational Resources Information Center

    Moy, Cheryl L.; Locke, Jonas R.; Coppola, Brian P.; McNeil, Anne J.

    2010-01-01

    This paper describes a graduate-level class project centered on editing chemistry-related entries in Wikipedia. This project enables students to work collaboratively, explore advanced concepts in chemistry, and learn how to communicate science to a diverse audience, including the general public. The format and structure of the project is outlined…

  14. Physics Lab Experiments and Correlated Computer Aids. Teacher Edition.

    ERIC Educational Resources Information Center

    Gottlieb, Herbert H.

    Forty-nine physics experiments are included in the teacher's edition of this laboratory manual. Suggestions are given in margins for preparing apparatus, organizing students, and anticipating difficulties likely to be encountered. Sample data, graphs, calculations, and sample answers to leading questions are also given for each experiment. It is…

  15. 49 CFR 395.15 - Automatic on-board recording devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... information concerning on-board system sensor failures and identification of edited data. Such support systems... driving today; (iv) Total hours on duty for the 7 consecutive day period, including today; (v) Total hours...-driver operation; (7) The on-board recording device/system identifies sensor failures and edited data...

  16. A Handbook of Alternatives to Corporal Punishment. Fourth Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Education, Oklahoma City.

    This handbook recognizes the growing trend away from traditional disciplinary tactics to a discipline policy that encourages student responsibility. This edition, published by the Oklahoma Department of Education, contains three sections. The first describes methods for creating a positive learning climate, some of which include evaluating teacher…

  17. Food Production, Management, and Services. Baking. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Gibson, LeRoy

    These instructional materials are intended for a course on food production, management, and services involved in baking. The following introductory information is included: use of this publication; competency profile; instructional/task analysis; related academic and workplace skills list; tools, materials, and equipment list; 13 references; and a…

  18. Opticalman 1 and C, Rate Training Manual. [1972 Revised Edition].

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    In this revised edition of an earlier publication (ED 070 574), fundamentals of optical instruments on board ships are presented in this rate training manual for regular navy and naval reserve personnel. The manual includes nine chapters: Introduction; Administration and Supervision; Nature of Light; Optical Alignment Instruments; Night Vision…

  19. Learn, Grow, Become. TSA Edition. Second Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This curriculum guide contains seven Technology Student Association (TSA) units of study for secondary students. The units focus on helping students to develop and apply social, civic, and technology-related skills and achieve course competencies in applied technology courses. Each of the instructional units includes some or all of the basic…

  20. A Short History of the Movies. Second Edition.

    ERIC Educational Resources Information Center

    Mast, Gerald

    This second edition of "A Short History of the Movies" includes expanded information and judgments about some of the "old masters" of film; an updated discussion of the "new masters"; and new sections on Japanese, Indian, and Czech cinema. In general, this history reveals significant trends in film history. American…

  1. The International Handbook of Universities. Twenty-Second Edition

    ERIC Educational Resources Information Center

    Palgrave Macmillan, 2010

    2010-01-01

    The new "International Handbook of Universities" is now 2-volumes and includes single-user access to World Higher Education Database Online. This "Twenty-second Edition" is the most comprehensive guide to university-level education worldwide, providing detailed information on higher education institutions that offer at least a post-graduate degree…

  2. Thirty-seventh supplement to the American Ornithologists' Union Check-list of North American birds

    USGS Publications Warehouse

    Monroe, Burt L.; Banks, Richard C.; Fitzpatrick, John W.; Howell, Thomas R.; Johnson, Ned K.; Ouellet, Henri; Remsen, J.V.; Storer, Robert W.

    1989-01-01

    This third supplement subsequent to the 6th edition (1983) of the A.O.U. "Check-list of North American Birds" consists of changes adopted by the Committee on Classification and Nomenclature as of 1 March 1989. The changes fall into nine categories: (1) six species are added to the main list (Pterodroma longirostris, Larus crassirostris, Streptopelia decaocto, Cocccyzus julieni, Chrysolampis mosquitus, Emberiza aureola) because of new distributional information; (2) five species (Ara cubensis, Chlorostilbon bracei, Empidonax occidentalis, Polioptila californica, Pipilo crissalis) are added to the main list because of the splitting of species already on the list; (3) one name (Anthus rubescens) is changed because of the splitting of a species from outside the Checklist area; (4) two names (Morus bassanus, Nyctanassa violacea) is removed from the main list to Appendix B because of re-evaluation of Northern Hemisphere records; (6) three species (Pterodrama rostrata, P. alba, P. solandri) are moved from Appendix A to Appendix B, and one (P. defilippiana) is added to Appendix B because of questionable sight records; (7)A.O.U. numbers are added to three species (Ciccaba virgata, Myiopagis viridicata, Molothrus bonariensis) on the basis on new distributional records or supporting data; (8) several corrections in spelling or citations are made; and (9) English names are changed for twelve species to accommodate worldwide usage of these names. No new distributional information is included except as indicated above (i.e. minor changes of distribution are not noted). These actions bring the number of species recognized as occurring in North America (main list) to 1,945.

  3. VizieR Online Data Catalog: Chromospherically Active Binaries (Strassmeier+ 1993)

    NASA Astrophysics Data System (ADS)

    Strassmeier, K. G.; Hall, D. S.; Fekel, F. C.

    1996-08-01

    Stars always appear in order of increasing right-ascension for the epoch 2000.0. For the current version of the catalog, the literature was searched through December 31, 1991 although a few later references are included. Additionally, some entries are cited with "private communication", which make this catalog also a first-hand source. A number in parentheses behind an entry always corresponds to a reference given in the bibliography. See the 1988 publication for specific requirements and restrictions in compiling these catalogs. See the source reference for more details about this catalog. The following binary systems, which were listed in the first edition of the catalog, were not included in the present edition due to insufficient evidence for chromospheric activity: eta And 26 Aql 4 UMi nu2 Sgr tau Sgr the following stars are chromospherically active but are components in a "wide" binary and were not included. HD 25893 HD 79211 Forty three new binary systems have been included in the present edition. (12 data files).

  4. Generation of gene edited birds in one generation using sperm transfection assisted gene editing (STAGE).

    PubMed

    Cooper, Caitlin A; Challagulla, Arjun; Jenkins, Kristie A; Wise, Terry G; O'Neil, Terri E; Morris, Kirsten R; Tizard, Mark L; Doran, Timothy J

    2017-06-01

    Generating transgenic and gene edited mammals involves in vitro manipulation of oocytes or single cell embryos. Due to the comparative inaccessibility of avian oocytes and single cell embryos, novel protocols have been developed to produce transgenic and gene edited birds. While these protocols are relatively efficient, they involve two generation intervals before reaching complete somatic and germline expressing transgenic or gene edited birds. Most of this work has been done with chickens, and many protocols require in vitro culturing of primordial germ cells (PGCs). However, for many other bird species no methodology for long term culture of PGCs exists. Developing methodologies to produce germline transgenic or gene edited birds in the first generation would save significant amounts of time and resource. Furthermore, developing protocols that can be readily adapted to a wide variety of avian species would open up new research opportunities. Here we report a method using sperm as a delivery mechanism for gene editing vectors which we call sperm transfection assisted gene editing (STAGE). We have successfully used this method to generate GFP knockout embryos and chickens, as well as generate embryos with mutations in the doublesex and mab-3 related transcription factor 1 (DMRT1) gene using the CRISPR/Cas9 system. The efficiency of the method varies from as low as 0% to as high as 26% with multiple factors such as CRISPR guide efficiency and mRNA stability likely impacting the outcome. This straightforward methodology could simplify gene editing in many bird species including those for which no methodology currently exists.

  5. Accurate detection for a wide range of mutation and editing sites of microRNAs from small RNA high-throughput sequencing profiles

    PubMed Central

    Zheng, Yun; Ji, Bo; Song, Renhua; Wang, Shengpeng; Li, Ting; Zhang, Xiaotuo; Chen, Kun; Li, Tianqing; Li, Jinyan

    2016-01-01

    Various types of mutation and editing (M/E) events in microRNAs (miRNAs) can change the stabilities of pre-miRNAs and/or complementarities between miRNAs and their targets. Small RNA (sRNA) high-throughput sequencing (HTS) profiles can contain many mutated and edited miRNAs. Systematic detection of miRNA mutation and editing sites from the huge volume of sRNA HTS profiles is computationally difficult, as high sensitivity and low false positive rate (FPR) are both required. We propose a novel method (named MiRME) for an accurate and fast detection of miRNA M/E sites using a progressive sequence alignment approach which refines sensitivity and improves FPR step-by-step. From 70 sRNA HTS profiles with over 1.3 billion reads, MiRME has detected thousands of statistically significant M/E sites, including 3′-editing sites, 57 A-to-I editing sites (of which 32 are novel), as well as some putative non-canonical editing sites. We demonstrated that a few non-canonical editing sites were not resulted from mutations in genome by integrating the analysis of genome HTS profiles of two human cell lines, suggesting the existence of new editing types to further diversify the functions of miRNAs. Compared with six existing studies or methods, MiRME has shown much superior performance for the identification and visualization of the M/E sites of miRNAs from the ever-increasing sRNA HTS profiles. PMID:27229138

  6. Gene Editing and Genetic Lung Disease. Basic Research Meets Therapeutic Application.

    PubMed

    Alapati, Deepthi; Morrisey, Edward E

    2017-03-01

    Although our understanding of the genetics and pathology of congenital lung diseases such as surfactant protein deficiency, cystic fibrosis, and alpha-1 antitrypsin deficiency is extensive, treatment options are lacking. Because the lung is a barrier organ in direct communication with the external environment, targeted delivery of gene corrective technologies to the respiratory system via intratracheal or intranasal routes is an attractive option for therapy. CRISPR/Cas9 gene-editing technology is a promising approach to repairing or inactivating disease-causing mutations. Recent reports have provided proof of concept by using CRISPR/Cas9 to successfully repair or inactivate mutations in animal models of monogenic human diseases. Potential pulmonary applications of CRISPR/Cas9 gene editing include gene correction of monogenic diseases in pre- or postnatal lungs and ex vivo gene editing of patient-specific airway stem cells followed by autologous cell transplant. Strategies to enhance gene-editing efficiency and eliminate off-target effects by targeting pulmonary stem/progenitor cells and the assessment of short-term and long-term effects of gene editing are important considerations as the field advances. If methods continue to advance rapidly, CRISPR/Cas9-mediated gene editing may provide a novel opportunity to correct monogenic diseases of the respiratory system.

  7. Application of the gene editing tool, CRISPR-Cas9, for treating neurodegenerative diseases.

    PubMed

    Kolli, Nivya; Lu, Ming; Maiti, Panchanan; Rossignol, Julien; Dunbar, Gary L

    2018-01-01

    Increased accumulation of transcribed protein from the damaged DNA and reduced DNA repair capability contributes to numerous neurological diseases for which effective treatments are lacking. Gene editing techniques provide new hope for replacing defective genes and DNA associated with neurological diseases. With advancements in using such editing tools as zinc finger nucleases (ZFNs), meganucleases, and transcription activator-like effector nucleases (TALENs), etc., scientists are able to design DNA-binding proteins, which can make precise double-strand breaks (DSBs) at the target DNA. Recent developments with the CRISPR-Cas9 gene-editing technology has proven to be more precise and efficient when compared to most other gene-editing techniques. Two methods, non-homologous end joining (NHEJ) and homology-direct repair (HDR), are used in CRISPR-Cas9 system to efficiently excise the defective genes and incorporate exogenous DNA at the target site. In this review article, we provide an overview of the CRISPR-Cas9 methodology, including its molecular mechanism, with a focus on how in this gene-editing tool can be used to counteract certain genetic defects associated with neurological diseases. Detailed understanding of this new tool could help researchers design specific gene editing strategies to repair genetic disorders in selective neurological diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches

    PubMed Central

    Pramstaller, Peter P.; Hicks, Andrew A.; Rossini, Alessandra

    2017-01-01

    Genome-editing technology has emerged as a powerful method that enables the generation of genetically modified cells and organisms necessary to elucidate gene function and mechanisms of human diseases. The clustered regularly interspaced short palindromic repeats- (CRISPR-) associated 9 (Cas9) system has rapidly become one of the most popular approaches for genome editing in basic biomedical research over recent years because of its simplicity and adaptability. CRISPR/Cas9 genome editing has been used to correct DNA mutations ranging from a single base pair to large deletions in both in vitro and in vivo model systems. CRISPR/Cas9 has been used to increase the understanding of many aspects of cardiovascular disorders, including lipid metabolism, electrophysiology and genetic inheritance. The CRISPR/Cas9 technology has been proven to be effective in creating gene knockout (KO) or knockin in human cells and is particularly useful for editing induced pluripotent stem cells (iPSCs). Despite these progresses, some biological, technical, and ethical issues are limiting the therapeutic potential of genome editing in cardiovascular diseases. This review will focus on various applications of CRISPR/Cas9 genome editing in the cardiovascular field, for both disease research and the prospect of in vivo genome-editing therapies in the future. PMID:29434642

  9. History and dating of the publication of the Philadelphia (1822) and London (1823) editions of Edwin James's Account of an expedition from Pittsburgh to the Rocky Mountains

    USGS Publications Warehouse

    Woodman, Neal

    2010-01-01

    The public record of Major Stephen H. Long's 1819–1820 exploration of the American north-west, Account of an expedition from Pittsburgh to the Rocky Mountains, compiled by Edwin James, contains valuable contributions regarding the natural landscapes, native peoples and wildlife of a mostly unexplored region of the American west compiled from the notes of some of America's foremost naturalists, and it includes the first descriptions of 67 new species. The original plan was to publish the Account in Philadelphia and London simultaneously, yet these two editions differ substantially in ways that are relevant to the taxonomic contributions in the work. It is generally assumed that the Philadelphia edition was published in early January 1823 and was available first, but little substantive evidence has been presented to support its priority over the London edition. Review of contemporary correspondence and periodicals indicates the Philadelphia edition was available and for sale on 31 December 1822, whereas the London edition was available in late February 1823. As previously assumed by most sources, the Philadelphia edition has priority of publication and is the authority for most species names. Its correct year of publication, however, is 1822 rather than 1823.

  10. Examining End-Of-Chapter Problems Across Editions of an Introductory Calculus-Based Physics Textbook

    NASA Astrophysics Data System (ADS)

    Xiao, Bin

    End-Of-Chapter (EOC) problems have been part of many physics education studies. Typically, only problems "localized" as relevant to a single chapter were used. This work examines how well this type of problem represents all EOC problems and whether EOC problems found in leading textbooks have changed over the past several decades. To investigate whether EOC problems have connections between chapters, I solved all problems of the E&M; chapters of the most recent edition of a popular introductory level calculus-based textbook and coded the equations used to solve each problem. These results were compared to the first edition of the same text. Also, several relevant problem features were coded for those problems and results were compared for sample chapters across all editions. My findings include two parts. The result of equation usage shows that problems in the E&M; chapters do use equations from both other E&M; chapters and non-E&M; chapters. This out-of-chapter usage increased from the first edition to the last edition. Information about the knowledge structure of E&M; chapters was also revealed. The results of the problem feature study show that most EOC problems have common features but there was an increase of diversity in some of the problem features across editions.

  11. Biodetection Technologies for First Responders: 2014 Edition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ozanich, Richard M.; Baird, Cheryl L.; Bartholomew, Rachel A.

    2014-03-28

    This report summarizes commercially-available, hand-portable technologies that can be used by first responders in the field. This is not meant to be an exhaustive list, nor an endorsement of any technology described herein. Rather, this report is meant to provide useful information about available technologies to help end-users make informed decisions about biodetection technology procurement and use. Information listed in this report is primarily vendor-provided; however, where possible it has been supplemented with additional information obtained from publications, reports, and websites. Manufacturers were given the chance to review summaries of their technologies from August through November 2013 to verify themore » accuracy of technical specifications, available references, and pricing.« less

  12. Merged infrared catalogue

    NASA Technical Reports Server (NTRS)

    Schmitz, M.; Brown, L. W.; Mead, J. M.; Nagy, T. A.

    1978-01-01

    A compilation of equatorial coordinates, spectral types, magnitudes, and fluxes from five catalogues of infrared observations is presented. This first edition of the Merged Infrared Catalogue contains 11,201 oservations from the Two-Micron Sky Survey, Observations of Infrared Radiation from Cool Stars, the Air Force Geophysics Laboratory four Color Infrared Sky Survey and its Supplemental Catalog, and from Catalog of 10 micron Celestial Objects (HALL). This compilation is a by-product of a computerized infrared data base under development at Goddard Space Flight Center; the objective is to maintain a complete and current record of all infrared observations from 1 micron m to 1000 micron m of nonsolar system objects. These observations are being placed into a standardized system.

  13. Japanese Guideline for Allergic Rhinitis 2014.

    PubMed

    Okubo, Kimihiro; Kurono, Yuichi; Fujieda, Shigeharu; Ogino, Satoshi; Uchio, Eiichi; Odajima, Hiroshi; Takenaka, Hiroshi

    2014-09-01

    Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. In Japan, the first guideline was prepared after a symposium held by the Japanese Society of Allergology in 1993. The current 7th edition was published in 2013, and is widely used today. To incorporate evidence based medicine (EBM) introduced from abroad, the most recent collection of evidence/literature was supplemented to the Practical Guideline for the Management of Allergic Rhinitis in Japan 2013. The revised guideline includes assessment of diagnosis/treatment and prescriptions for children and pregnant women, for broad clinical applications. An evidence-based step-by-step strategy for treatment is also described. In addition, the QOL concept and cost benefit analyses are also addressed. Along with Allergic Rhinitis and its Impact of Asthma (ARIA), this guideline is widely used for various clinical purposes, such as measures for patients with sinusitis, childhood allergic rhinitis, oral allergy syndrome, and anaphylaxis and for pregnant women. A Q&A section regarding allergic rhinitis in Japan was added to the end of this guideline.

  14. Genome engineering in human cells.

    PubMed

    Song, Minjung; Kim, Young-Hoon; Kim, Jin-Soo; Kim, Hyongbum

    2014-01-01

    Genome editing in human cells is of great value in research, medicine, and biotechnology. Programmable nucleases including zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases recognize a specific target sequence and make a double-strand break at that site, which can result in gene disruption, gene insertion, gene correction, or chromosomal rearrangements. The target sequence complexities of these programmable nucleases are higher than 3.2 mega base pairs, the size of the haploid human genome. Here, we briefly introduce the structure of the human genome and the characteristics of each programmable nuclease, and review their applications in human cells including pluripotent stem cells. In addition, we discuss various delivery methods for nucleases, programmable nickases, and enrichment of gene-edited human cells, all of which facilitate efficient and precise genome editing in human cells.

  15. Engineering Delivery Vehicles for Genome Editing.

    PubMed

    Nelson, Christopher E; Gersbach, Charles A

    2016-06-07

    The field of genome engineering has created new possibilities for gene therapy, including improved animal models of disease, engineered cell therapies, and in vivo gene repair. The most significant challenge for the clinical translation of genome engineering is the development of safe and effective delivery vehicles. A large body of work has applied genome engineering to genetic modification in vitro, and clinical trials have begun using cells modified by genome editing. Now, promising preclinical work is beginning to apply these tools in vivo. This article summarizes the development of genome engineering platforms, including meganucleases, zinc finger nucleases, TALENs, and CRISPR/Cas9, and their flexibility for precise genetic modifications. The prospects for the development of safe and effective viral and nonviral delivery vehicles for genome editing are reviewed, and promising advances in particular therapeutic applications are discussed.

  16. Constructs and methods for genome editing and genetic engineering of fungi and protists

    DOEpatents

    Hittinger, Christopher Todd; Alexander, William Gerald

    2018-01-30

    Provided herein are constructs for genome editing or genetic engineering in fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. The constructs may also include selectable markers for use in selecting recombinations.

  17. Illustrated glossary of process equipment. Chinese/English/French edition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Paruit, B.

    1984-01-01

    Here is a volume of process equipment and terms in standard Mandarin Chinese, English, and French. As with the English/French/Spanish edition, each page illustrates a particular piece of equipment, with captions identifying the key components. Glossaries at the end of each major section include the Romanized pronunciation of the Chinese.

  18. Hermann Paul and General Linguistic Theory

    ERIC Educational Resources Information Center

    Koerner, E. F. K.

    2008-01-01

    In most history of linguistics textbooks available until today Hermann Paul and his "Principles of Historical Linguistics," first published in 1880 and still available in reprints of the fifth edition of 1920, if given any attention at all, is cited for a statement he included in the second edition of 1886 in response to a review that…

  19. Adolescent Literacy Resources: An Annotated Bibliography. Second Edition 2009

    ERIC Educational Resources Information Center

    Center on Instruction, 2009

    2009-01-01

    This annotated bibliography updated from a 2007 edition, is intended as a resource for technical assistance providers as they work with states on adolescent literacy. This revision includes current research and documents of practical use in guiding improvements in grades 4-12 reading instruction in the content areas and in interventions for…

  20. Instructional Supervision: Applying Tools and Concepts. 2nd Edition

    ERIC Educational Resources Information Center

    Zepeda, Sally J.

    2007-01-01

    The first edition of this book was highly regarded by both professors and students for its practicality and its: (1) coverage of tools & strategies to help supervisors work effectively with teachers; (2) up-to-date approach to clinical supervision which includes teacher portfolios, action research, peer coaching, and other innovative practices;…

  1. Gas Metal Arc Welding and Flux-Cored Arc Welding. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Fortney, Clarence; Gregory, Mike

    These instructional materials are designed to improve instruction in Gas Metal Arc Welding (GMAW) and Flux-Cored Arc Welding (FCAW). The following introductory information is included: use of this publication; competency profile; instructional/task analysis; related academic and workplace skills list; tools, materials, and equipment list; and…

  2. Exporting Our Disorders

    ERIC Educational Resources Information Center

    Foltz, Robert

    2012-01-01

    In 2013, the American Psychiatric Association will release its newest Diagnostic and Statistical Manual, 5th Edition (DSM-5). This tome has evolved over the decades, originally including just 112 diagnoses across 128 pages. The upcoming edition is expected to eclipse the 943 pages, and 350+ disorders of the current DSM-IV-TR, offering a variety of…

  3. Global Issues 89/90. Fifth Edition. Annual Editions Series.

    ERIC Educational Resources Information Center

    Jackson, Robert, Ed.

    This book is one in a series designed to provide access to a wide range of selected articles from magazines, newspapers, and journals. This volume contains 55 articles by scientists, educators, researchers, and writers providing effective and useful perspectives on today's important topics in the study of global issues. Articles included in this…

  4. Linguistic Variability and Intellectual Development. Miami Linguistics Series No. 9.

    ERIC Educational Resources Information Center

    von Humboldt, Wilhelm

    Although this edition of Wilhelm von Humboldt's "Linguistic Variability and Intellectual Development" is based entirely on the original German edition, the translators (George C. Buck and Frithjof A. Raven) and the publisher have attempted to clarify certain aspects of this work for the modern-day reader. These features include the addition of…

  5. The Economy of Energy Conservation in Educational Facilities. A Report. Revised Edition.

    ERIC Educational Resources Information Center

    Educational Facilities Labs., Inc., New York, NY.

    This is an update of the 1973 edition of a guide for energy conservation in schools. This Educational Facilities Laboratories publication is an information source for teachers, school administrators, school maintenance personnel, school designers, or anyone interested in conserving energy in schools. Topics discussed include: (1) life-cycle…

  6. Does Money Matter in Education? Second Edition

    ERIC Educational Resources Information Center

    Baker, Bruce D.

    2016-01-01

    This second edition policy brief revisits the long and storied literature on whether money matters in providing a quality education. It includes research released since the original brief in 2012 and covers a handful of additional topics. Increasingly, political rhetoric adheres to the unfounded certainty that money does not make a difference in…

  7. A Guide to Ohio Outdoor Education Areas. Second Edition.

    ERIC Educational Resources Information Center

    Melvin, Ruth W.

    To this new and updated second edition, over 160 new sites and their description have been added. The first major section, outdoor education areas, includes state Parks, forests, and wildlife areas; historic sites and memorials; Wayne National Forest; metropolitan county and city parks; agency and private camps; conservation agency properties;…

  8. Archaeology. Second Teacher Edition. Grades 5-12.

    ERIC Educational Resources Information Center

    Stark, Rebecca

    This book includes a student edition by the same name and introduces students to various civilizations and their achievements. The self-directed activities emphasize higher-level thinking skills and activities keyed to "Bloom's Taxonomy." The table of contents lists: (1) "What Is Archaeology?"; (2) "What Is Culture?"; (3) "Where to Dig"; (4)…

  9. Outdoor Biology Instructional Strategies Trial Edition, Set IV.

    ERIC Educational Resources Information Center

    Throgmorton, Larry, Ed.; And Others

    Eight games are included in the 24 activities in the Outdoor Biology Instructional Strategies (OBIS) Trial Edition Set IV. There are also simulations, crafts, biological techniques, and organism investigations focusing on animal and plant life in the forest, desert, and snow. Designed for small groups of children ages 10 to 15 from schools and…

  10. Food Production, Management, and Services. Production. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Gibson, LeRoy

    This teacher's guide contains 20 units of instruction for a course in production in the food production, management, and services area. Units of instruction are designed for use in more than one lesson or class period of instruction. Introductory materials include the following: a competency profile; instructional/task analysis; related academic…

  11. Insider's Guide to Community College Administration. Second Edition

    ERIC Educational Resources Information Center

    Jensen, Robert; Giles, Ray

    2006-01-01

    Drawing from their varied experiences, the authors of this helpful guide, now in its second edition, offer firsthand advice on the skills and attitude needed to succeed as a community college leader. Topics include: (1) Making the right career choices; (2) Thriving and surviving on the job; (3) Navigating institutional politics; (4) Taking the…

  12. Law and American Education: A Case Brief Approach. Third Edition

    ERIC Educational Resources Information Center

    Palestini, Robert; Falk, Karen Palestini

    2012-01-01

    This third edition expands coverage on such topics as the law and students with disabilities, confidentiality, sexual harassment, student searches and tuition vouchers. It also includes some new topics such as bullying, copyright law, and the law and the internet. Both public and nonpublic school educators are aware that courts, over the last…

  13. Polyhedron Models for the Classroom. Second Edition.

    ERIC Educational Resources Information Center

    Wenninger, Magnus J.

    This second edition explains the historical background and techniques for constructing various types of polyhedra. Seven center-fold sheets are included, containing full-scale drawings from which nets or templates may be made to construct the models shown and described in the text. Details are provided for construction of the five Platonic solids,…

  14. National Profile of Community Colleges: Trends and Statistics, 4th Edition

    ERIC Educational Resources Information Center

    Phillippe, Kent A.; Sullivan, Leila Gonzalez

    2005-01-01

    This book offers a national view of trends and statistics related to today's community colleges. The new edition includes completely revised text as well as updates to charts and tables on topics such as enrollment, student outcomes, population, curriculum, faculty, workforce, and financial aid. Informative narrative introduces and provides…

  15. Bifactor Structure of the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition

    ERIC Educational Resources Information Center

    Watkins, Marley W.; Beaujean, A. Alexander

    2014-01-01

    The Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI-IV; Wechsler, 2012) represents a substantial departure from its predecessor, including omission of 4 subtests, addition of 5 new subtests, and modification of the contents of the 5 retained subtests. Wechsler (2012) explicitly assumed a higher-order structure with…

  16. Teen Success! Ideas to Move Your Mind. (2nd Edition)

    ERIC Educational Resources Information Center

    Elye, Beatrice J.

    2007-01-01

    This new edition will guide teenagers toward success with updated ideas and suggestions that today's teens can relate to. Perfect for at home or in the classroom, this conversational book can help give your teenager practical life skills and enlightened insights. Chapter topics include decision making, speed reading, building confidence, time…

  17. Theories of Educational Leadership and Management. Third Edition

    ERIC Educational Resources Information Center

    Bush, Tony

    2003-01-01

    In this established bestselling text, Tony Bush presents the major theories of educational management and links them to contemporary policy and practice. This fully revised Third Edition includes two important changes in content. First, the book takes account of the increasing interest in the concept of leadership. Leadership continues to be one…

  18. Kaleidoscope: A Multicultural Booklist for Grades K-8. Third Edition. NCTE Bibliography Series.

    ERIC Educational Resources Information Center

    Yokota, Junko, Ed.

    The third edition of this annotated bibliography collection offers students, teachers, and librarians a helpful guide to the best multicultural literature (published between 1996 and 1998) for elementary and middle school readers. With approximately 600 annotations on topics and formats including picture story books, realistic fiction, history and…

  19. Konkordanz zu Schillers aesthetischen und philosophischen Schriften (Concordance of Schiller's Aesthetic and Philosophical Writings).

    ERIC Educational Resources Information Center

    Sanford, Gerlinde Ulm

    This document provides a computer-based concordance of the vocabulary used in Friedrich von Schiller's "Aesthetic and Philosophical Writings" as they appear in Volumes 20 and 21 of Schiller's "Werke," 1967 edition, edited by Benno von Wiese. The first section includes the entire text, each sentence numbered for research…

  20. A Case Study Approach to Ethics in Career Development, Second Edition. Monograph Series

    ERIC Educational Resources Information Center

    Makela, Julia Panke; Perlus, Jessamyn G.

    2017-01-01

    This second edition tackles some of the most vexing questions that career development professionals encounter today. Using a case study design, it offers a hands-on experience with ethical terminology, resources, and issues. Each dilemma presented includes detailed, guided discussion of key issues and recommendations, with direct connections to…

  1. Part C Updates: 9th Edition

    ERIC Educational Resources Information Center

    Danaher, Joan; Goode, Sue; Lazara, Alex

    2007-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the ninth volume in a series of compilations, which included two editions of Part H Updates, the former name of the…

  2. What Shall I Read on Japan? An Introductory Guide. Twelfth Edition.

    ERIC Educational Resources Information Center

    Marks, Alfred H.

    This highly selective annotated list of works may be read with profit by the serious beginning student or casual reader interested in things Japanese. As many entries as possible from the earlier editions have been retained. All new materials cited were reviewed. Included are reference books, guides, fiction, novels, translations, research…

  3. A Comprehensive Guide to Intellectual and Developmental Disabilities. Second Edition

    ERIC Educational Resources Information Center

    Wehmeyer, Michael L.. Ed.; Brown, Ivan, Ed.; Percy, Maire, Ed.; Fung, W. L. Alan, Ed.; Shogren, Karrie A., Ed.

    2017-01-01

    The trusted core disability textbook gets a comprehensive update in this second edition, now thoroughly revised to include all the critical topics today's professionals need to know about as they work with people who have intellectual and developmental disabilities. Brought to you by a new team of world-renowned experts and contributors, this…

  4. The Monthly Sky Guide: Sixth Edition

    NASA Astrophysics Data System (ADS)

    Ridpath, Ian; Tirion, Wil

    2003-06-01

    The latest edition of Ian Ridpath and Wil Tirion's popular guide to the night sky is updated for planet positions and forthcoming eclipses up to the end of the year 2007. With one chapter for each month of the year, this is an easy-to-use handbook for anyone wanting to identify constellations, star clusters, nebulae, to plot the movement of planets, or witness solar and lunar eclipses. Most of the features discussed are visible to the naked eye and all can be seen with a small telescope or binoculars. Ian Ridpath has been a full-time writer, broadcaster and lecturer on astronomy and space for more than twenty-five years. He has written and edited more than 40 books, including A Comet Called Haley (Cambridge, 1985). Wil Tirion made his first star map in 1977. It showed stars to the magnitude of 6.5 and was issued as a set of maps by the British Astronomical Association in 1981. He has illustrated numerous books and magazines, including The Cambridge Star Atlas (Cambridge, 2001). Previous Edition Pb (1999): 0-521-66771-2

  5. The preliminary analysis of the reliability and validity of the Chinese Edition of the CSBS DP.

    PubMed

    Lin, Chu-Sui; Chang, Shu-Hui; Cheng, Shu-Fen; Chao, Pen-Chiang; Chiu, Chun-Hao

    2015-03-01

    This study marked a preliminary attempt to standardize the Chinese Edition of the Communication and Symbolic Behavior Scales Developmental Profile (Wetherby & Prizant, 2002; CSBS DP) to assist in the early identification of young children with special needs in Taiwan. The study was conducted among 171 infants and toddlers aged 1-2. It also included a follow-up study one year after the initial test. Three domestically developed standardized child development inventories were used to measure the concurrent validity and predictive validity. The Chinese Edition of the CSBS DP demonstrated overall good test-retest and inter-rater reliability. It also showed good concurrent and predictive validity. The current study yields preliminary evidence that the Chinese Edition of the CSBS DP could be a valuable assessment tool worthy of wider distribution. Future research should employ random sampling to establish a true national norm. Additionally, the follow-up study needs to include atypical groups and to expand to children aged 6-12 months to strengthen the applicability of the instrument in Taiwan. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Naval Observatory Vector Astrometry Software (NOVAS) Version 3.1, Introducing a Python Edition

    NASA Astrophysics Data System (ADS)

    Barron, Eric G.; Kaplan, G. H.; Bangert, J.; Bartlett, J. L.; Puatua, W.; Harris, W.; Barrett, P.

    2011-01-01

    The Naval Observatory Vector Astrometry Software (NOVAS) is a source-code library that provides common astrometric quantities and transformations. NOVAS calculations are accurate at the sub-milliarcsecond level. The library can supply, in one or two subroutine or function calls, the instantaneous celestial position of any star or planet in a variety of coordinate systems. NOVAS also provides access to all of the building blocks that go into such computations. NOVAS Version 3.1 introduces a Python edition alongside the Fortran and C editions. The Python edition uses the computational code from the C edition and, currently, mimics the function calls of the C edition. Future versions will expand the functionality of the Python edition to harness the object-oriented nature of the Python language, and will implement the ability to handle large quantities of objects or observers using the array functionality in NumPy (a third-party scientific package for Python). NOVAS 3.1 also adds a module to transform GCRS vectors to the ITRS; the ITRS to GCRS transformation was already provided in NOVAS 3.0. The module that corrects an ITRS vector for polar motion has been modified to undo that correction upon demand. In the C edition, the ephemeris-access functions have been revised for use on 64-bit systems and for improved performance in general. NOVAS, including documentation, is available from the USNO website (http://www.usno.navy.mil/USNO/astronomical-applications/software-products/novas).

  7. Trypanosoma brucei RNA Editing Complex

    PubMed Central

    O'Hearn, Sean F.; Huang, Catherine E.; Hemann, Mike; Zhelonkina, Alevtina; Sollner-Webb, Barbara

    2003-01-01

    Maturation of Trypanosoma brucei mitochondrial mRNA involves massive posttranscriptional insertion and deletion of uridine residues. This RNA editing utilizes an enzymatic complex with seven major proteins, band I through band VII. We here use RNA interference (RNAi) to examine the band II and band V proteins. Band II is found essential for viability; it is needed to maintain the normal structure of the editing complex and to retain the band V ligase protein. Previously, band III was found essential for certain activities, including maintenance of the editing complex and retention of the band IV ligase protein. Thus, band II and band V form a protein pair with features analogous to the band III/band IV ligase pair. Since band V is specific for U insertion and since band IV is needed for U deletion, their parallel organization suggests that the editing complex has a pseudosymmetry. However, unlike the essential band IV ligase, RNAi to band V has only a morphological but no growth rate effect, suggesting that it is stimulatory but nonessential. Indeed, in vitro analysis of band V RNAi cell extract demonstrates that band IV can seal U insertion when band V is lacking. Thus, band IV ligase is the first activity of the basic editing complex shown able to serve in both forms of editing. Our studies also indicate that the U insertional portion may be less central in the editing complex than the corresponding U deletional portion. PMID:14560033

  8. To CRISPR and beyond: the evolution of genome editing in stem cells

    PubMed Central

    Chen, Kuang-Yui; Knoepfler, Paul S

    2016-01-01

    The goal of editing the genomes of stem cells to generate model organisms and cell lines for genetic and biological studies has been pursued for decades. There is also exciting potential for future clinical impact in humans. While recent, rapid advances in targeted nuclease technologies have led to unprecedented accessibility and ease of gene editing, biology has benefited from past directed gene modification via homologous recombination, gene traps and other transgenic methodologies. Here we review the history of genome editing in stem cells (including via zinc finger nucleases, transcription activator-like effector nucleases and CRISPR–Cas9), discuss recent developments leading to the implementation of stem cell gene therapies in clinical trials and consider the prospects for future advances in this rapidly evolving field. PMID:27905217

  9. Systems and methods for an extensible business application framework

    NASA Technical Reports Server (NTRS)

    Bell, David G. (Inventor); Crawford, Michael (Inventor)

    2012-01-01

    Method and systems for editing data from a query result include requesting a query result using a unique collection identifier for a collection of individual files and a unique identifier for a configuration file that specifies a data structure for the query result. A query result is generated that contains a plurality of fields as specified by the configuration file, by combining each of the individual files associated with a unique identifier for a collection of individual files. The query result data is displayed with a plurality of labels as specified in the configuration file. Edits can be performed by querying a collection of individual files using the configuration file, editing a portion of the query result, and transmitting only the edited information for storage back into a data repository.

  10. To CRISPR and beyond: the evolution of genome editing in stem cells.

    PubMed

    Chen, Kuang-Yui; Knoepfler, Paul S

    2016-12-01

    The goal of editing the genomes of stem cells to generate model organisms and cell lines for genetic and biological studies has been pursued for decades. There is also exciting potential for future clinical impact in humans. While recent, rapid advances in targeted nuclease technologies have led to unprecedented accessibility and ease of gene editing, biology has benefited from past directed gene modification via homologous recombination, gene traps and other transgenic methodologies. Here we review the history of genome editing in stem cells (including via zinc finger nucleases, transcription activator-like effector nucleases and CRISPR-Cas9), discuss recent developments leading to the implementation of stem cell gene therapies in clinical trials and consider the prospects for future advances in this rapidly evolving field.

  11. Common use of dietary supplements for bipolar disorder: a naturalistic, self-reported study.

    PubMed

    Bauer, Michael; Glenn, Tasha; Conell, Jörn; Rasgon, Natalie; Marsh, Wendy; Sagduyu, Kemal; Munoz, Rodrigo; Lewitzka, Ute; Bauer, Rita; Pilhatsch, Maximilian; Monteith, Scott; Whybrow, Peter C

    2015-12-01

    Dietary supplements are taken by about half of Americans. Knowledge of dietary supplement use is important because they may interact with prescription drugs or other supplements, cause adverse reactions including psychiatric symptoms, or contain inherently toxic ingredients or contaminants. This study explores the use of dietary supplements by patients with bipolar disorder in the US. Data were obtained from an ongoing, naturalistic study of patients with bipolar disorder who received pharmacological treatment as usual. The patients self-reported their daily mood, sleep, and medications taken, including all drugs prescribed for bipolar disorder or that the patient felt impacted their mood. These included other prescribed drugs, over-the-counter drugs and dietary supplements. Drugs that received premarketing approval from the FDA were not included as dietary supplements. Patient demographics and daily medication use were characterized. Data were available from 348 patients in the US who returned a mean 249.5 days of data. In addition to prescribed psychiatric drugs, 101 of the 348 patients (29 %) used a dietary supplement for at least 7 days and 69 (20 %) used a supplement long term (for at least 50 % of days). Of the 101 supplement users, 72 (71.3 %) took one supplement daily. The 101 patients tried over 40 different supplements, and the long-term users took 19 different supplements. The most commonly taken supplements for both groups were fish oil, B vitamins, melatonin, and multivitamins. Patients using supplements were more likely to be white (p < 0.001), older (p = 0.009), and ill for more years (p = 0.025). Many patients with bipolar disorder use dietary supplements in addition to prescribed drugs. Physicians should obtain detailed information about all dietary supplements taken by patients with bipolar disorder.

  12. Massive gene transfer and extensive RNA editing of a symbiotic dinoflagellate plastid genome.

    PubMed

    Mungpakdee, Sutada; Shinzato, Chuya; Takeuchi, Takeshi; Kawashima, Takeshi; Koyanagi, Ryo; Hisata, Kanako; Tanaka, Makiko; Goto, Hiroki; Fujie, Manabu; Lin, Senjie; Satoh, Nori; Shoguchi, Eiichi

    2014-05-31

    Genome sequencing of Symbiodinium minutum revealed that 95 of 109 plastid-associated genes have been transferred to the nuclear genome and subsequently expanded by gene duplication. Only 14 genes remain in plastids and occur as DNA minicircles. Each minicircle (1.8-3.3 kb) contains one gene and a conserved noncoding region containing putative promoters and RNA-binding sites. Nine types of RNA editing, including a novel G/U type, were discovered in minicircle transcripts but not in genes transferred to the nucleus. In contrast to DNA editing sites in dinoflagellate mitochondria, which tend to be highly conserved across all taxa, editing sites employed in DNA minicircles are highly variable from species to species. Editing is crucial for core photosystem protein function. It restores evolutionarily conserved amino acids and increases peptidyl hydropathy. It also increases protein plasticity necessary to initiate photosystem complex assembly. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  13. Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system.

    PubMed

    Cheong, Taek-Chin; Compagno, Mara; Chiarle, Roberto

    2016-03-09

    Applications of the CRISPR-Cas9 system to edit the genome have widely expanded to include DNA gene knock-out, deletions, chromosomal rearrangements, RNA editing and genome-wide screenings. Here we show the application of CRISPR-Cas9 technology to edit the mouse and human immunoglobulin (Ig) genes. By delivering Cas9 and guide-RNA (gRNA) with retro- or lenti-virus to IgM(+) mouse B cells and hybridomas, we induce class-switch recombination (CSR) of the IgH chain to the desired subclass. Similarly, we induce CSR in all human B cell lines tested with high efficiency to targeted IgH subclass. Finally, we engineer mouse hybridomas to secrete Fab' fragments instead of the whole Ig. Our results indicate that Ig genes in mouse and human cells can be edited to obtain any desired IgH switching helpful to study the biology of normal and lymphoma B cells. We also propose applications that could transform the technology of antibody production.

  14. May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells.

    PubMed

    Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David A

    2017-02-06

    In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods.

  15. May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells

    PubMed Central

    Brookhouser, Nicholas; Raman, Sreedevi; Potts, Christopher; Brafman, David. A.

    2017-01-01

    In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regenerative medicine applications. More recently, the development and refinement of advanced gene transduction and editing technologies have further accelerated the potential of hiPSCs. In this review, we discuss the various gene editing technologies that are being implemented with hiPSCs. Specifically, we describe the emergence of technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 that can be used to edit the genome at precise locations, and discuss the strengths and weaknesses of each of these technologies. In addition, we present the current applications of these technologies in elucidating the mechanisms of human development and disease, developing novel and effective therapeutic molecules, and engineering cell-based therapies. Finally, we discuss the emerging technological advances in targeted gene editing methods. PMID:28178187

  16. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF) data in HDF (CER_SSF_Terra-FM2-MODIS_Edition2A)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2003-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  17. CERES Single Satellite Footprint, TOA and Surface Fluxes, Clouds (SSF) data in HDF (CER_SSF_Aqua-FM4-MODIS_Edition2A)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-09-16] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  18. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF) data in HDF (CER_SSF_Aqua-FM4-MODIS_Edition1B)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2005-03-29] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  19. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF)- Test data in HDF (CER_SSF_TRMM-PFM-VIRS_Subset-Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=1998-08-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  20. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF) data in HDF (CER_SSF_Terra-FM2-MODIS_Edition2B)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-01-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  1. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF) data in HDF (CER_SSF_TRMM-PFM-VIRS_Edition1)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2000-03-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  2. CERES Single Scanner Satellite Footprint, TOA, Surface Fluxes and Clouds (SSF) data in HDF (CER_SSF_Terra-FM1-MODIS_Edition2A)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2003-12-31] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  3. A biochemical landscape of A-to-I RNA editing in the human brain transcriptome

    PubMed Central

    Sakurai, Masayuki; Ueda, Hiroki; Yano, Takanori; Okada, Shunpei; Terajima, Hideki; Mitsuyama, Toutai; Toyoda, Atsushi; Fujiyama, Asao; Kawabata, Hitomi; Suzuki, Tsutomu

    2014-01-01

    Inosine is an abundant RNA modification in the human transcriptome and is essential for many biological processes in modulating gene expression at the post-transcriptional level. Adenosine deaminases acting on RNA (ADARs) catalyze the hydrolytic deamination of adenosines to inosines (A-to-I editing) in double-stranded regions. We previously established a biochemical method called “inosine chemical erasing” (ICE) to directly identify inosines on RNA strands with high reliability. Here, we have applied the ICE method combined with deep sequencing (ICE-seq) to conduct an unbiased genome-wide screening of A-to-I editing sites in the transcriptome of human adult brain. Taken together with the sites identified by the conventional ICE method, we mapped 19,791 novel sites and newly found 1258 edited mRNAs, including 66 novel sites in coding regions, 41 of which cause altered amino acid assignment. ICE-seq detected novel editing sites in various repeat elements as well as in short hairpins. Gene ontology analysis revealed that these edited mRNAs are associated with transcription, energy metabolism, and neurological disorders, providing new insights into various aspects of human brain functions. PMID:24407955

  4. In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting.

    PubMed

    Chen, Xiaoyu; Janssen, Josephine M; Liu, Jin; Maggio, Ignazio; 't Jong, Anke E J; Mikkers, Harald M M; Gonçalves, Manuel A F V

    2017-09-22

    Precise genome editing involves homologous recombination between donor DNA and chromosomal sequences subjected to double-stranded DNA breaks made by programmable nucleases. Ideally, genome editing should be efficient, specific, and accurate. However, besides constituting potential translocation-initiating lesions, double-stranded DNA breaks (targeted or otherwise) are mostly repaired through unpredictable and mutagenic non-homologous recombination processes. Here, we report that the coordinated formation of paired single-stranded DNA breaks, or nicks, at donor plasmids and chromosomal target sites by RNA-guided nucleases based on CRISPR-Cas9 components, triggers seamless homology-directed gene targeting of large genetic payloads in human cells, including pluripotent stem cells. Importantly, in addition to significantly reducing the mutagenicity of the genome modification procedure, this in trans paired nicking strategy achieves multiplexed, single-step, gene targeting, and yields higher frequencies of accurately edited cells when compared to the standard double-stranded DNA break-dependent approach.CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often repaired by mutagenic non-homologous end-joining. Here the authors use Cas9 nickases to generate coordinated single-strand breaks in donor and target DNA for precise homology-directed gene editing.

  5. Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans

    PubMed Central

    Paix, Alexandre; Wang, Yuemeng; Smith, Harold E.; Lee, Chih-Yung S.; Calidas, Deepika; Lu, Tu; Smith, Jarrett; Schmidt, Helen; Krause, Michael W.; Seydoux, Geraldine

    2014-01-01

    Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome editing, but is thought to be less efficient than error-prone nonhomologous end joining in most cell types. We have investigated HDR of double-strand breaks induced by CRISPR-associated protein 9 (Cas9) in Caenorhabditis elegans. We find that HDR is very robust in the C. elegans germline. Linear repair templates with short (∼30–60 bases) homology arms support the integration of base and gene-sized edits with high efficiency, bypassing the need for selection. Based on these findings, we developed a systematic method to mutate, tag, or delete any gene in the C. elegans genome without the use of co-integrated markers or long homology arms. We generated 23 unique edits at 11 genes, including premature stops, whole-gene deletions, and protein fusions to antigenic peptides and GFP. Whole-genome sequencing of five edited strains revealed the presence of passenger variants, but no mutations at predicted off-target sites. The method is scalable for multi-gene editing projects and could be applied to other animals with an accessible germline. PMID:25249454

  6. Media Evaluations and Dissemination by Indian Americans. A Catalogue of Evaluations of Selected Print and Non-print Materials and Index to Additional Resource Materials Pertaining to American Indians and Alaska Natives. Revised 2nd Edition.

    ERIC Educational Resources Information Center

    National Indian Education Association, Minneapolis, Minn.

    The second edition of the Media Resources Catalogue, this document is considerably reduced in size and includes only evaluated materials. The five sections of this catalogue are as follows: (1) print materials (categorized as fiction and non-fiction, this section includes 55 and 239 citations, respectively and is further categorized in terms of…

  7. Gene correction in patient-specific iPSCs for therapy development and disease modeling

    PubMed Central

    Jang, Yoon-Young

    2018-01-01

    The discovery that mature cells can be reprogrammed to become pluripotent and the development of engineered endonucleases for enhancing genome editing are two of the most exciting and impactful technology advances in modern medicine and science. Human pluripotent stem cells have the potential to establish new model systems for studying human developmental biology and disease mechanisms. Gene correction in patient-specific iPSCs can also provide a novel source for autologous cell therapy. Although historically challenging, precise genome editing in human iPSCs is becoming more feasible with the development of new genome-editing tools, including ZFNs, TALENs, and CRISPR. iPSCs derived from patients of a variety of diseases have been edited to correct disease-associated mutations and to generate isogenic cell lines. After directed differentiation, many of the corrected iPSCs showed restored functionality and demonstrated their potential in cell replacement therapy. Genome-wide analyses of gene-corrected iPSCs have collectively demonstrated a high fidelity of the engineered endonucleases. Remaining challenges in clinical translation of these technologies include maintaining genome integrity of the iPSC clones and the differentiated cells. Given the rapid advances in genome-editing technologies, gene correction is no longer the bottleneck in developing iPSC-based gene and cell therapies; generating functional and transplantable cell types from iPSCs remains the biggest challenge needing to be addressed by the research field. PMID:27256364

  8. NASA Pocket Statistics: 1997 Edition

    NASA Technical Reports Server (NTRS)

    1997-01-01

    POCKET STATISTICS is published by the NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (NASA). Included in each edition is Administrative and Organizational information, summaries of Space Flight Activity including the NASA Major Launch Record, Aeronautics and Space Transportation and NASA Procurement, Financial and Workforce data. The NASA Major Launch Record includes all launches of Scout class and larger vehicles. Vehicle and spacecraft development flights are also included in the Major Launch Record. Shuttle missions are counted as one launch and one payload, where free flying payloads are not involved. All Satellites deployed from the cargo bay of the Shuttle and placed in a separate orbit or trajectory are counted as an additional payload.

  9. Handbook of ecotoxicology, second edition

    USGS Publications Warehouse

    Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

    2003-01-01

    Handbook of Ecotoxicology, Second Edition focuses on toxic substances and how they affect ecosystems worldwide. It presents methods for quantifying and measuring ecotoxicological effects in the field and in the lab, as well as methods for estimating, predicting, and modeling in ecotoxicology studies. Completely revised and updated with 18 new chapters, this second edition includes contributions from over 75 international experts. Also, a Technical Review Board reviewed all manuscripts for accuracy and currency. This authoritative work is the definitive reference for students, researchers, consultants, and other professionals in the environmental sciences, toxicology, chemistry, biology, and ecology - in academia, industry, and government.

  10. Principles of Optics

    NASA Astrophysics Data System (ADS)

    Born, Max; Wolf, Emil

    1999-10-01

    Principles of Optics is one of the classic science books of the twentieth century, and probably the most influential book in optics published in the past forty years. This edition has been thoroughly revised and updated, with new material covering the CAT scan, interference with broad-band light and the so-called Rayleigh-Sommerfeld diffraction theory. This edition also details scattering from inhomogeneous media and presents an account of the principles of diffraction tomography to which Emil Wolf has made a basic contribution. Several new appendices are also included. This new edition will be invaluable to advanced undergraduates, graduate students and researchers working in most areas of optics.

  11. General Chemistry Collection for Students (CD-ROM), Abstract of Special Issue 16, 4th Edition

    NASA Astrophysics Data System (ADS)

    2000-07-01

    The General Chemistry Collection contains both new and previously published JCE Software programs that are intended for use by introductory-level chemistry students. These peer-reviewed programs for Macintosh and for Windows are available on a single CD-ROM for convenient distribution to and access by students, and the CD may be adopted for students to purchase as they would a textbook. General Chemistry Collection covers a broad range of topics providing students with interesting information, tutorials, and simulations that will be useful to them as they study chemistry for the first time. There are 22 programs included in the General Chemistry Collection 4th Edition. Their titles and the general chemistry topics they cover are listed in Table 1. Features in This Edition General Chemistry Collection, 4th edition includes:

    • Lessons for Introductory Chemistry and INQUAL-S, two new programs not previously published by JCE Software (abstracts appear below)
    • Writing Electron Dot Structures (1) and Viscosity Measurement: A Virtual Experiment for Windows (2), two programs published individually by JCE Software
    • Periodic Table Live! LE, a limited edition of Periodic Table Live!, 2nd Edition (3) (this replaces Chemistry Navigator (4) and Illustrated Periodic Table (5))
    • Many of the programs from previous editions (6)1
    Hardware and Software Requirements System requirements are given in Table 2. Some programs have additional requirements. See the individual program abstracts at JCE Online, or documentation included on the CD-ROM for more specific information. Licensing and Discounts for Adoptions The General Chemistry Collection is intended for use by individual students. Institutions and faculty members may adopt General Chemistry Collection 4th Edition as they would a textbook. We can arrange for CDs to be packaged with laboratory manuals or other course materials or to be sold for direct distribution to students through the campus bookstore. The cost per CD can be quite low when large numbers are ordered (as little as $3 each), making this a cost-effective method of allowing students access to the software they need whenever and wherever they desire. Other JCE Software CDs can also be adopted. Network licenses to distribute the software to your students via your local campus network can also be arranged. Contact us for details on purchasing multiple user licenses. Price and Ordering An order form is inserted in this issue that provides prices and other ordering information. If this card is not available or if you need additional information, contact: JCE Software, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706-1396; phone; 608/262-5153 or 800/991-5534; fax: 608/265-8094; email: jcesoft@chem.wisc.edu. Table 1. Contents of the General Chemistry Collection, 4th Edition

  12. The CRISPR/Cas Genome-Editing Tool: Application in Improvement of Crops

    PubMed Central

    Khatodia, Surender; Bhatotia, Kirti; Passricha, Nishat; Khurana, S. M. P.; Tuteja, Narendra

    2016-01-01

    The Clustered Regularly Interspaced Short Palindromic Repeats associated Cas9/sgRNA system is a novel targeted genome-editing technique derived from bacterial immune system. It is an inexpensive, easy, most user friendly and rapidly adopted genome editing tool transforming to revolutionary paradigm. This technique enables precise genomic modifications in many different organisms and tissues. Cas9 protein is an RNA guided endonuclease utilized for creating targeted double-stranded breaks with only a short RNA sequence to confer recognition of the target in animals and plants. Development of genetically edited (GE) crops similar to those developed by conventional or mutation breeding using this potential technique makes it a promising and extremely versatile tool for providing sustainable productive agriculture for better feeding of rapidly growing population in a changing climate. The emerging areas of research for the genome editing in plants include interrogating gene function, rewiring the regulatory signaling networks and sgRNA library for high-throughput loss-of-function screening. In this review, we have described the broad applicability of the Cas9 nuclease mediated targeted plant genome editing for development of designer crops. The regulatory uncertainty and social acceptance of plant breeding by Cas9 genome editing have also been described. With this powerful and innovative technique the designer GE non-GM plants could further advance climate resilient and sustainable agriculture in the future and maximizing yield by combating abiotic and biotic stresses. PMID:27148329

  13. Effects of prenatal multiple micronutrient supplementation on growth and cognition through 2 y of age in rural Bangladesh: the JiVitA-3 Trial.

    PubMed

    Christian, Parul; Kim, Jeongyong; Mehra, Sucheta; Shaikh, Saijuddin; Ali, Hasmot; Shamim, Abu Ahmed; Wu, Lee; Klemm, Rolf; Labrique, Alain B; West, Keith P

    2016-10-01

    Childhood undernutrition may have prenatal origins, and the impact of prenatal interventions on postnatal growth is not well known. We assessed the effects of prenatal multiple micronutrient (MM) supplementation on child growth and cognitive development. In a cluster-randomized controlled trial in rural Bangladesh, prenatal MM supplementation compared with iron-folic acid (IFA) supplementation was examined for its impact on growth assessed longitudinally from birth up to 24 mo of age (n = 8529) and, in a subsample (n = 734), on cognitive function at 24 mo of age by use of the Bayley scales of infant and toddler development-third edition test. Prevalence of stunting at birth [length for age z score (LAZ): <-2] was 31.9% in the MM and 35.7% in the IFA groups (P < 0.001); however, LAZ increased during the first 3-4 mo in both groups. With the use of a linear random-effects model, prenatal MM-exposed children sustained a higher mean predicted LAZ of ∼0.10 at 1 and 3 mo and 0.06 at 6 mo of age compared with children in the IFA group. Supplementation reduced the prevalence of stunting at 1 (RR: 0.95; 95% CI: 0.92, 0.98) and 3 (RR: 0.91; 95% CI: 0.88, 0.94) mo of age. Differences between groups were absent by 6, 12, and 24 mo of age, when nearly 50% of children had stunted growth. Ponderal and linear growth velocities were somewhat slower from 3 to 12 mo of age in the MM group than in the IFA group, but not from 12 to 24 mo of age. There was no difference between groups on composite scores of cognition, language, and motor performance at 24 mo of age. In this Bangladeshi trial, maternal pre- and postnatal MM supplementation resulted in improvements in LAZ and reduction in stunting through 3 mo of age, but not thereafter and had no impact on cognitive and motor function at 2 y. This trial was registered at clinicaltrials.gov as NCT000860470. © 2016 American Society for Nutrition.

  14. Effect of low-dose versus higher-dose antenatal iron supplementation on child health outcomes at 36 months of age in Viet Nam: longitudinal follow-up of a cluster randomised controlled trial.

    PubMed

    Hanieh, Sarah; Ha, Tran T; Simpson, Julie A; Braat, Sabine; Thuy, Tran T; Tran, Thach D; King, Janet; Tuan, Tran; Fisher, Jane; Biggs, Beverley-Ann

    2017-01-01

    Intermittent iron-folic acid supplementation (IFA) is currently recommended for pregnant women in populations where anaemia prevalence among pregnant women is <20% or if daily iron is not acceptable. The effect of providing lower doses of antenatal elemental iron through intermittent regimes on longer-term health outcomes in childhood is unclear. A prospective cohort study conducted between May 2012 and May 2014 in Viet Nam among children of 36 months of age, born to women previously enrolled in a cluster randomised controlled trial of antenatal micronutrient supplementation (daily IFA (60 mg elemental iron) vs twice-weekly IFA (60 mg elemental iron) vs twice-weekly multiple micronutrient (MMN) supplementation (60 mg elemental iron)). Primary outcomes were height-for-age z-scores (HAZ), according to WHO growth standards and cognitive composite scores (Bayley Scales of Infant and Toddler Development, third edition) at 36 months of age. A total of 1017 children born to mothers enrolled in the cluster randomised trial were assessed at 36 months of age. Adjusted mean differences (MDs) in HAZ were -0.14 (95% CI -0.28 to -0.01) and -0.15 (95% CI -0.29 to -0.01) in children born to mothers who received twice-weekly IFA or MMN compared with those who received daily IFA. Children born to mothers who received twice-weekly MMN had lower composite motor scores compared with those who received daily IFA (MD -2.07, 95% CI -4.11 to -0.03). There were no differences in composite cognitive scores in the twice-weekly compared with daily regimens. Low-dose antenatal IFA supplementation (120 mg elemental iron per week) resulted in lower HAZ and motor composite scores in children compared with higher-dose antenatal IFA supplementation (420 mg elemental iron per week). This highlights the importance of adequate iron stores during pregnancy and the need for careful monitoring when lower-dose antenatal iron regimens are used. Australia New Zealand Clinical Trials Registry: 12610000944033.

  15. Helping Children at Home and School II: Handouts for Families and Educators

    ERIC Educational Resources Information Center

    Canter, Andrea S., Ed.; Paige, Leslie Z., Ed.; Roth, Mark D., Ed.; Romero, Ivonne, Ed.; Carroll, Servio A., Ed.

    2004-01-01

    This document builds on the success of earlier editions. It includes a number of substantially revised handouts updated from the previous editions, plus many new topics that reflect the challenges parents and educators face in the 21st century. Many handouts for families are also provided in Spanish. This document is a comprehensive resource for…

  16. Inventory America: Residential Buildings. Student Workbook, Pilot Edition; Teacher & Project Supervisor Manual, Pilot Edition.

    ERIC Educational Resources Information Center

    Haupt, Richard; Pomeroy, Robert W., Ed.

    Designed as a special studies unit for secondary school students or for adult volunteers, this student workbook and teacher's guide explains how to produce an accurate record of memorable neighborhood houses. The activities in the workbook include observation and information gathering. The workbook sections describe various steps in the process…

  17. 78 FR 56715 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... minutes, automatically generate the SPL document (a few formatting edits may have to be made). Based on... render it as intended in SPL. The comment said that most users need to apply applicable formatting to..., including MS Word (both editable and hard- formatted), faxes, texts, in emails, or other scanned documents...

  18. Watershed Dynamics. Teacher Edition (Includes the Full Student Edition). Cornell Scientific Inquiry Series

    ERIC Educational Resources Information Center

    Carlsen, William S.; Trautmann, Nancy M.

    2004-01-01

    Whether you're a stream studies novice or a veteran aquatic monitor, "Watershed Dynamics" gives you abundant practical resources to extend your students' investigations into local water quality and land-use issues. This two-part set is ideal for teaching biological and ecological concepts and research techniques. It also shows how the interplay…

  19. Theoretical Models and Processes of Reading. Fourth Edition.

    ERIC Educational Resources Information Center

    Ruddell, Robert B., Ed.; And Others

    Serving as a source of questions for researchers to investigate and a resource for professors and their students, this book presents 51 essays that discuss where the reading field has been, is now, and might be going. More than 80% of the essays are new or revised from the third edition. Essays in the book include "Professional Connections:…

  20. Basic Science Living Skills for Today's World. Teacher's Edition.

    ERIC Educational Resources Information Center

    Zellers (Robert W.) Educational Services, Johnstown, PA.

    This document is a teacher's edition of a basic skills curriculum in science for adult basic education (ABE) students. The course consists of 25 lessons on basic science concepts, designed to give students a good understanding of the biological and physical sciences. Suggested activities and experiments that the student can do are also included.…

  1. Mutagenesis of FAD2 genes in peanut with CRISPR/Cas9

    USDA-ARS?s Scientific Manuscript database

    The CRISPR/Cas9 system is known for its precise and efficient gene-editing of a targeted region in a variety of organisms including plants. We targeted FAD2 gene region to perform CRISPR/Cas9 gene-editing in peanut. The FAD2 gene encodes fatty acid desaturase which catalyzes the conversion of oleic ...

  2. Master Curriculum Guide in Economics. A Framework for Teaching the Basic Concepts. Second Edition.

    ERIC Educational Resources Information Center

    Saunders, Phillip; And Others

    Intended for curriculum developers, this revised Framework presents a set of basic concepts for teaching K-12 economics. The revision reflects the change and development which the field of economics has undergone and includes improvements suggested by users of the first edition. The purpose of teaching economics is to impart a general…

  3. Measuring up to the Model: A Ranking of State Charter School Laws. Seventh Edition

    ERIC Educational Resources Information Center

    Ziebarth, Todd

    2016-01-01

    This seventh edition of "Measuring up to the Model: A Ranking of State Charter School Laws" presents the latest activity in charter public school legislation across the country. Some highlights include: (1) significant activity regarding potential enabling legislation in several of the states without charter public school laws, (2)…

  4. Hands-On Life Science Activities for Middle Schools. Teacher's Edition. First Edition.

    ERIC Educational Resources Information Center

    Newman, Barbara; Kramer, Stephanie

    This book provides 50 enrichment activities for the science curriculum that provide concrete connections with important world events. Each activity is self-contained and provides everything the student needs to gain a basic understanding of a concept or to work through a project. The activities include innovative and traditional projects for both…

  5. Insider's Guide to Graduate Programs in Clinical and Counseling Psychology. 2006/2007 Edition

    ERIC Educational Resources Information Center

    Mayne, Tracy J.; Norcross, John C.; Sayette, Michael A.

    2006-01-01

    Now in its 2006-2007 edition, this perennial bestseller is the resource students count on for the most current information on applying to doctoral programs in clinical or counseling psychology. The Insider's Guide presents up-to-date facts on 300 accredited programs in the United States and Canada. Each program's profile includes admissions…

  6. Reading for Understanding: How Reading Apprenticeship Improves Disciplinary Learning in Secondary and College Classrooms. Second Edition

    ERIC Educational Resources Information Center

    Schoenbach, Ruth; Greenleaf, Cynthia; Murphy, Lynn

    2012-01-01

    Published in partnership with WestEd, this significantly updated second edition of the bestselling book contains strategies for helping students in middle school through community college gain the reading independence to master subject area textbooks and other material. Features of this book include: (1) Based on the Reading Apprenticeship…

  7. The Bowker Annual Library and Book Trade Almanac, 2002. 47th Edition.

    ERIC Educational Resources Information Center

    Bogart, Dave, Ed.

    This 47th edition is a compilation of practical information and informed analysis of interest to the library, information, and book trade worlds. The volume is divided into six parts. Part 1 includes six Special Reports, as well as reports on the year's activities from federal agencies, federal libraries, and national and international library and…

  8. Taking the Lead: New Roles for Teachers and School-Based Coaches, 2nd Edition

    ERIC Educational Resources Information Center

    Killion, Joellen; Harrison, Cindy

    2017-01-01

    "Taking the Lead" outlines 10 practical and powerful roles for school-based coaches responsible for helping teachers increase their capacity to serve all students. The second edition is a rich update to Killion and Harrison's essential resource and includes dozens of online tools that support deep exploration and implementation of the…

  9. Guide to the Administration of Charitable Remainder Trusts. Third Edition.

    ERIC Educational Resources Information Center

    Clark, David W.; And Others

    This is the third edition of a workbook prepared as a kind of primer for those responsible for the administration of charitable remainder trusts in accordance with the Tax Reform Act of 1969. The topics covered include: trust administration in general; pooled income fund; unitrust; annuity trust; gift annuity; short term income (lead) trust; gift…

  10. Teachers and the Law. Sixth Edition.

    ERIC Educational Resources Information Center

    Fischer, Louis; Schimmel, David; Stellman, Leslie

    This book is about teachers and the laws that affect them. New to this sixth edition are new court cases and a chapter that highlights likely controversies in the coming years, including school choice, high-stakes testing, control of the Internet, and gang clothing. The book is divided into two parts. Part I, "The Legal Aspects of Teaching,"…

  11. Documentation in Counseling Records. Second Edition. The ACA Legal Series.

    ERIC Educational Resources Information Center

    Mitchell, Robert

    In an age of legal, clinical, and fiscal accountability, record keeping is an important component of professional counseling. The second edition of this book is intended to be used to: (1) explain the uses of a case record and who has access to it; (2) comprehend everyday problems associated with ineffective communication, including how records…

  12. Construct Validity Evidence for Bracken School Readiness Assessment, Third Edition, Spanish Form Scores

    ERIC Educational Resources Information Center

    Ortiz, Arlene; Clinton, Amanda; Schaefer, Barbara A.

    2015-01-01

    Convergent and discriminant validity evidence was examined for scores on the Spanish Record Form of the Bracken School Readiness Assessment, Third Edition (BSRA-3). Participants included a sample of 68 Hispanic, Spanish-speaking children ages 4 to 5 years enrolled in preschool programs in Puerto Rico. Scores obtained from the BSRA-3 Spanish Record…

  13. Study Guide--What Great Principals Do Differently: Eighteen Things That Matter Most. Second Edition

    ERIC Educational Resources Information Center

    Whitaker, Beth; Whitaker, Todd; Zoul, Jeffrey

    2012-01-01

    Designed to be used by facilitators and participants in seminars, book study groups, or other professional development events, this book guides critical thinking, collaboration, and professional growth based on the concepts in Todd Whitaker's best-selling title, "What Great Principals Do Differently" (2nd edition). Each chapter includes: (1) Key…

  14. The Education Almanac, 1987-1988. Facts and Figures about Our Nation's System of Education. Third Edition.

    ERIC Educational Resources Information Center

    Goodman, Leroy V., Ed.

    This is the third edition of the Education Almanac, an assemblage of statistics, facts, commentary, and basic background information about the conduct of schools in the United States. Features of this variegated volume include an introductory section on "Education's Newsiest Developments," followed by some vital educational statistics, a set of…

  15. Analysis of effects of manhole covers on motorcycle driver maneuvers: a nonparametric classification tree approach.

    PubMed

    Chang, Li-Yen

    2014-01-01

    A manhole cover is a removable plate forming the lid over the opening of a manhole to allow traffic to pass over the manhole and to prevent people from falling in. Because most manhole covers are placed in roadway traffic lanes, if these manhole covers are not appropriately installed or maintained, they can represent unexpected hazards on the road, especially for motorcycle drivers. The objective of this study is to identify the effects of manhole cover characteristics as well as driver factors and traffic and roadway conditions on motorcycle driver maneuvers. A video camera was used to record motorcycle drivers' maneuvers when they encountered an inappropriately installed or maintained manhole cover. Information on 3059 drivers' maneuver decisions was recorded. Classification and regression tree (CART) models were applied to explore factors that can significantly affect motorcycle driver maneuvers when passing a manhole cover. Nearly 50 percent of the motorcycle drivers decelerated or changed their driving path to reduce the effects of the manhole cover. The manhole cover characteristics including the level difference between manhole cover and pavement, the pavement condition over the manhole cover, and the size of the manhole cover can significantly affect motorcycle driver maneuvers. Other factors, including traffic conditions, lane width, motorcycle speed, and loading conditions, also have significant effects on motorcycle driver maneuvers. To reduce the effects and potential risks from the manhole covers, highway authorities not only need to make sure that any newly installed manhole covers are as level as possible but also need to regularly maintain all the manhole covers to ensure that they are in good condition. In the long run, the size of manhole covers should be kept as small as possible so that the impact of manhole covers on motorcycle drivers can be effectively reduced. Supplemental materials are available for this article. Go to the publisher's online edition of Traffic Injury Prevention to view the supplemental file.

  16. Nutritional Supplements for Strength Power Athletes

    NASA Astrophysics Data System (ADS)

    Wilborn, Colin

    Over the last decade research involving nutritional supplementation and sport performance has increased substantially. Strength and power athletes have specific needs to optimize their performance. Nutritional supplementation cannot be viewed as a replacement for a balanced diet but as an important addition to it. However, diet and supplementation are not mutually exclusive, nor does one depend on the other. Strength and power athletes have four general areas of supplementation needs. First, strength athletes need supplements that have a direct effect on performance. The second group of supplements includes those that promote recovery. The third group comprises the supplements that enhance immune function. The last group of supplements includes those that provide energy or have a direct effect on the workout. This chapter reviews the key supplements needed to optimize the performance and training of the strength athlete.

  17. DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes

    PubMed Central

    Knisbacher, Binyamin A.; Levanon, Erez Y.

    2016-01-01

    Long terminal repeat retrotransposons (LTR) are widespread in vertebrates and their dynamism facilitates genome evolution. However, these endogenous retroviruses (ERVs) must be restricted to maintain genomic stability. The APOBECs, a protein family that can edit C-to-U in DNA, do so by interfering with reverse transcription and hypermutating retrotransposon DNA. In some cases, a retrotransposon may integrate into the genome despite being hypermutated. Such an event introduces a unique sequence into the genome, increasing retrotransposon diversity and the probability of developing new function at the locus of insertion. The prevalence of this phenomenon and its effects on vertebrate genomes are still unclear. In this study, we screened ERV sequences in the genomes of 123 diverse species and identified hundreds of thousands of edited sites in multiple vertebrate lineages, including placental mammals, marsupials, and birds. Numerous edited ERVs carry high mutation loads, some with greater than 350 edited sites, profoundly damaging their open-reading frames. For many of the species studied, this is the first evidence that APOBECs are active players in their innate immune system. Unexpectedly, some birds and especially zebra finch and medium ground-finch (one of Darwin’s finches) are exceptionally enriched in DNA editing. We demonstrate that edited retrotransposons may be preferentially retained in active genomic regions, as reflected from their enrichment in genes, exons, promoters, and transcription start sites, thereby raising the probability of their exaptation for novel function. In conclusion, DNA editing of retrotransposons by APOBECs has a substantial role in vertebrate innate immunity and may boost genome evolution. PMID:26541172

  18. The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation.

    PubMed

    Zhang, Hui; Zhang, Jinshan; Wei, Pengliang; Zhang, Botao; Gou, Feng; Feng, Zhengyan; Mao, Yanfei; Yang, Lan; Zhang, Heng; Xu, Nanfei; Zhu, Jian-Kang

    2014-08-01

    The CRISPR/Cas9 system has been demonstrated to efficiently induce targeted gene editing in a variety of organisms including plants. Recent work showed that CRISPR/Cas9-induced gene mutations in Arabidopsis were mostly somatic mutations in the early generation, although some mutations could be stably inherited in later generations. However, it remains unclear whether this system will work similarly in crops such as rice. In this study, we tested in two rice subspecies 11 target genes for their amenability to CRISPR/Cas9-induced editing and determined the patterns, specificity and heritability of the gene modifications. Analysis of the genotypes and frequency of edited genes in the first generation of transformed plants (T0) showed that the CRISPR/Cas9 system was highly efficient in rice, with target genes edited in nearly half of the transformed embryogenic cells before their first cell division. Homozygotes of edited target genes were readily found in T0 plants. The gene mutations were passed to the next generation (T1) following classic Mendelian law, without any detectable new mutation or reversion. Even with extensive searches including whole genome resequencing, we could not find any evidence of large-scale off-targeting in rice for any of the many targets tested in this study. By specifically sequencing the putative off-target sites of a large number of T0 plants, low-frequency mutations were found in only one off-target site where the sequence had 1-bp difference from the intended target. Overall, the data in this study point to the CRISPR/Cas9 system being a powerful tool in crop genome engineering. © 2014 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  19. Edited synoptic cloud reports from ships and land stations over the globe, 1982--1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hahn, C.J.; Warren, S.G.; London, J.

    1996-02-01

    Surface synoptic weather reports for the entire globe for the 10-year period from December 1981 through November 1991 have been processed, edited, and rewritten to provide a data set designed for use in cloud analyses. The information in these reports relating to clouds, including the present weather information, was extracted and put through a series of quality control checks. Correctable inconsistencies within reports were edited for consistency, so that the ``edited cloud report`` can be used for cloud analysis. Cases of ``sky obscured`` were interpreted by reference to the present weather code as to whether they indicated fog, rain ormore » snow and were given appropriate cloud type designations. Nimbostratus clouds were also given a special designation. Changes made to an original report are indicated in the edited report so that the original report can be reconstructed if desired. While low cloud amount is normally given directly in the synoptic report, the edited cloud report also includes the amounts, either directly reported or inferred, of middle and high clouds, both the non-overlapped amounts and the ``actual`` amounts. Since illumination from the moon is important for the adequate detection of clouds at night, both the relative lunar illuminance and the solar altitude are given; well as a parameter that indicates whether our recommended illuminance criterion was satisfied. This data set contains 124 million reports from land stations and 15 million reports from ships. Each report is 56 characters in length. The archive consists of 240 files, one file for each month of data for land and ocean separately. With this data set a user can develop a climatology for any particular cloud type or group of types, for any geographical region and any spatial and temporal resolution desired.« less

  20. CERES Single Satellite Footprint, TOA and Surface Fluxes, Clouds (SSF) data in HDF (CER_SSF_Aqua-FM4-MODIS_Ed2A-NoSW)

    NASA Technical Reports Server (NTRS)

    Wielicki, Bruce A. (Principal Investigator)

    The Single Scanner Footprint TOA/Surface Fluxes and Clouds (SSF) product contains one hour of instantaneous Clouds and the Earth's Radiant Energy System (CERES) data for a single scanner instrument. The SSF combines instantaneous CERES data with scene information from a higher-resolution imager such as Visible/Infrared Scanner (VIRS) on TRMM or Moderate-Resolution Imaging Spectroradiometer (MODIS) on Terra and Aqua. Scene identification and cloud properties are defined at the higher imager resolution and these data are averaged over the larger CERES footprint. For each CERES footprint, the SSF contains the number of cloud layers and for each layer the cloud amount, height, temperature, pressure, optical depth, emissivity, ice and liquid water path, and water particle size. The SSF also contains the CERES filtered radiances for the total, shortwave (SW), and window (WN) channels and the unfiltered SW, longwave (LW), and WN radiances. The SW, LW, and WN radiances at spacecraft altitude are converted to Top-of-the-Atmosphere (TOA) fluxes based on the imager defined scene. These TOA fluxes are used to estimate surface fluxes. Only footprints with adequate imager coverage are included on CER_SSF_TRMM-PFM-VIRS_Subset_Edition1the SSF which is much less than the full set of footprints on the CERES ES-8 product. The following CERES SSF data sets are currently available: CER_SSF_TRMM-PFM-VIRS_Edition1 CER_SSF_TRMM-PFM-VIRS_Subset_Edition1 CER_SSF_TRMM-PFM-VIRS_Edition2A CER_SSF_TRMM-SIM-VIRS_Edition2_VIRSonly CER_SSF_TRMM-PFM-VIRS_Edition2A-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B-TransOps CER_SSF_TRMM-PFM-VIRS_Edition2B CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition1A CER_SSF_Terra-FM1-MODIS_Edition2A CER_SSF_Terra-FM2-MODIS_Edition2A CER_SSF_Terra-FM1-MODIS_Edition2B CER_SSF_Terra-FM2-MODIS_Edition2B CER_SSF_Aqua-FM4-MODIS_Beta1 CER_SSF_Aqua-FM3-MODIS_Beta2 CER_SSF_Aqua-FM4-MODIS_Beta2. [Location=GLOBAL] [Temporal_Coverage: Start_Date=1998-01-01; Stop_Date=2006-01-01] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Temporal_Resolution=1 hour; Temporal_Resolution_Range=Hourly - < Daily].

  1. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).

    PubMed

    Nishida, Osamu; Ogura, Hiroshi; Egi, Moritoki; Fujishima, Seitaro; Hayashi, Yoshiro; Iba, Toshiaki; Imaizumi, Hitoshi; Inoue, Shigeaki; Kakihana, Yasuyuki; Kotani, Joji; Kushimoto, Shigeki; Masuda, Yoshiki; Matsuda, Naoyuki; Matsushima, Asako; Nakada, Taka-Aki; Nakagawa, Satoshi; Nunomiya, Shin; Sadahiro, Tomohito; Shime, Nobuaki; Yatabe, Tomoaki; Hara, Yoshitaka; Hayashida, Kei; Kondo, Yutaka; Sumi, Yuka; Yasuda, Hideto; Aoyama, Kazuyoshi; Azuhata, Takeo; Doi, Kent; Doi, Matsuyuki; Fujimura, Naoyuki; Fuke, Ryota; Fukuda, Tatsuma; Goto, Koji; Hasegawa, Ryuichi; Hashimoto, Satoru; Hatakeyama, Junji; Hayakawa, Mineji; Hifumi, Toru; Higashibeppu, Naoki; Hirai, Katsuki; Hirose, Tomoya; Ide, Kentaro; Kaizuka, Yasuo; Kan'o, Tomomichi; Kawasaki, Tatsuya; Kuroda, Hiromitsu; Matsuda, Akihisa; Matsumoto, Shotaro; Nagae, Masaharu; Onodera, Mutsuo; Ohnuma, Tetsu; Oshima, Kiyohiro; Saito, Nobuyuki; Sakamoto, So; Sakuraya, Masaaki; Sasano, Mikio; Sato, Norio; Sawamura, Atsushi; Shimizu, Kentaro; Shirai, Kunihiro; Takei, Tetsuhiro; Takeuchi, Muneyuki; Takimoto, Kohei; Taniguchi, Takumi; Tatsumi, Hiroomi; Tsuruta, Ryosuke; Yama, Naoya; Yamakawa, Kazuma; Yamashita, Chizuru; Yamashita, Kazuto; Yoshida, Takeshi; Tanaka, Hiroshi; Oda, Shigeto

    2018-01-01

    The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM , [2017; Volume 24 (supplement 2)] 10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine. Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members. A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs. Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

  2. Book Review: New Perspectives on Technical Editing

    NASA Astrophysics Data System (ADS)

    Murphy, A. J. (Ed.); Sterken, Christiaan

    2012-08-01

    New Perspectives on Technical Editing by Avon J. Murphy (ed.) ISBN : 978-0895033949 (2010) Baywood Publishing Company Inc, Hardcover, 210 pages, 35.5 GBP This book presents a collection of 10 chapters dealing with diverse aspects of technical editing (ie, editorial planning, and analysis and structural changes made to other people's technological documents): research in technical editing, trends and teaching of technical editing, copyediting, and technical journal editing. The role and function of the modern journal and book editor is also dealt with in detail. Each chapter is written by an expert in the field: senior editors, university professors in technical communication, technical writers and linguists. The ever-evolving role of the editor is clearly elucidated in several historical reviews, and in the descriptions of the expectations for the future. A very striking aspect of this book is its extensive collection of bibliographic resources: every chapter lists dozens of very useful references, and the closing chapter, and annotated bibliography, contain many not so well known references, and are most useful. All in all, the book is a treasure trove listing more than 400 references, in addition to numerous webpage URLs embedded in the texts. The book is designed to help the reader to understand current practices and norms in technical editing, and to help to take action in editing as well as in teaching and educating would-be editors. The audience for this book thus includes editors and teachers, but also writers, researchers and students. A deep reading of this book will result in a better understanding of the difference between full technical editing and its much narrower component so well known as copyediting, and will convince any prospective editor that editing should not be undertaken if the people involved do not master the art of precision and accuracy in technical (as well as in human) communication, do not possess the technical know how and computer skills, or do not have a very broad knowledge base. The language fluency of every contributor makes this book a pleasure to read, and this particular volume of Baywood's Technical Communications Series is very well edited. The subject index covers almost 8 two-column pages.

  3. Overview of the 9th International Conference on Hydrodynamics

    NASA Astrophysics Data System (ADS)

    Lu, Dong-qiang

    2010-10-01

    The 9th International Conference on Hydrodynamics (ICHD), held in Shanghai, China from 11 to 15 October, 2010, was briefly reviewed. More than 240 delegates from 23 countries and regions attended this Conference, at which three plenary lectures, two keynote lectures and more than 160 papers were delivered. A special symposium on hydrodynamics in honor of Prof. You-sheng He was jointly organized in this ICHD. The printed proceedings, edited by Y. S. Wu, S. Q. Dai, H. Liu et al. and published by China Ocean Press, collect 172 technical papers contributed from 26 countries and regions. The electronic proceedings are distributed by the Elsevier at the ScienceDirect website as "Journal of Hydrodynamics, 2010, Vol. 22, No. 5 (Supplement)".

  4. Geophysical events

    NASA Astrophysics Data System (ADS)

    This is a summary of SEAN Bulletin, 13(2), February 29, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-002 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $ 1.

  5. A step-up test procedure to find the minimum effective dose.

    PubMed

    Wang, Weizhen; Peng, Jianan

    2015-01-01

    It is of great interest to find the minimum effective dose (MED) in dose-response studies. A sequence of decreasing null hypotheses to find the MED is formulated under the assumption of nondecreasing dose response means. A step-up multiple test procedure that controls the familywise error rate (FWER) is constructed based on the maximum likelihood estimators for the monotone normal means. When the MED is equal to one, the proposed test is uniformly more powerful than Hsu and Berger's test (1999). Also, a simulation study shows a substantial power improvement for the proposed test over four competitors. Three R-codes are provided in Supplemental Materials for this article. Go to the publishers online edition of Journal of Biopharmaceutical Statistics to view the files.

  6. Readers' evaluation of effect of peer review and editing on quality of articles in the Nederlands Tijdschrift voor Geneeskunde.

    PubMed

    Pierie, J P; Walvoort, H C; Overbeke, A J

    1996-11-30

    Academic biomedical journals use peer review and editing to help to select and improve the quality of articles. We have investigated whether articles accepted by the Nederlands Tijdschrift voor Geneeskunde, the Dutch Journal of Medicine, were improved after peer review and editing (post-acceptance scientific and copy editing). 400 readers of the journal (100 each of medical students, recent medical graduates, general practitioners, and specialists) were invited to participate in a questionnaire survey. The first 25 from each group who agreed to participate were included. We posted a pack containing a set of identically appearing typescripts (ie, blinding) of the submitted, accepted, and published versions of 50 articles that had been published in Ned Tijdschr Geneeskd. Each evaluator received two of the sets of versions, and each set was evaluated by one person from each group. The package also included two questionnaires: the first was used to compare the submitted with the accepted version (25 questions), the second compared the accepted with the published version (17 questions). The questions were answered on five-point scales, and were about the quality of the articles or were general/overall scores. We analysed the data as scores of 3-5 (ie, improvement) versus 1-2. After peer review, the quality in 14 of 23 questions (61%) was significantly improved (p = 0.03 or smaller). In particular, the overall score and general medical value were significantly improved (p = 0.00001 for each). Editing led to significant improvement in 11 of 16 questions (69%, p = 0.017 or smaller), and especially in style and readability (p = 0.001 and p = 0.004). Generally, we found no differences between the scores of the four categories of evaluators. 72% of the evaluators correctly identified which version was which. Evaluations by readers of the Ned Tijdschr Geneeskd indicated significant improvement of published articles after both peer review and editing. We think that peer review and editing are worthwhile tasks. We also think that possible biases would have had a negligible effect on our results (including the fact that we selected the first 25 evaluators who responded, that some evaluators may have read the published version, and that one questionnaire may have looked more scientific than the other, more editorial one).

  7. Directory of Michigan Library Statistics. 1994 Edition. Reporting 1992 and 1993 Statistical Activities including: Public Library Statistics, Library Cooperative Statistics, Regional/Subregional Statistics.

    ERIC Educational Resources Information Center

    Leaf, Donald C., Comp.; Neely, Linda, Comp.

    This edition focuses on statistical data supplied by Michigan public libraries, public library cooperatives, and those public libraries which serve as regional or subregional outlets for blind and physically handicapped services. Since statistics in Michigan academic libraries are typically collected in odd-numbered years, they are not included…

  8. Grants and Awards Available to American Writers. 7th Edition.

    ERIC Educational Resources Information Center

    P.E.N. American Center, New York, NY.

    This is the seventh edition of a comprehensive list of grants and awards available to American writers for use in the United States and abroad. Generally, only those grants and prizes which have a value of $500 or more have been listed. Approximately 250 grants and awards are included, along with the address of the sponsoring organizations, any…

  9. Challenging Science and Literacy Activities for K-9 Students--The Cricket Chronicles. Teacher Edition

    ERIC Educational Resources Information Center

    Matthews, Catherine E.

    2006-01-01

    This book is an extensive integrated unit of study focused on that common and familiar insect--the cricket. In this edition, teachers are given a complete guide and reproducible worksheets for elementary and middle school students. With over 30 different activities on crickets, students learn science content and skills including: (1) Taxonomy; (2)…

  10. Video Editing System

    NASA Technical Reports Server (NTRS)

    Schlecht, Leslie E.; Kutler, Paul (Technical Monitor)

    1998-01-01

    This is a proposal for a general use system based, on the SGI IRIS workstation platform, for recording computer animation to videotape. In addition, this system would provide features for simple editing and enhancement. Described here are a list of requirements for the system, and a proposed configuration including the SGI VideoLab Integrator, VideoMedia VLAN animation controller and the Pioneer rewritable laserdisc recorder.

  11. Student Services: A Handbook for the Profession. Third Edition. The Jossey-Bass Higher and Adult Education Series.

    ERIC Educational Resources Information Center

    Komives, Susan R.; Woodard, Dudley B., Jr.

    A solid foundation in current literature in the field of student affairs is provided. New in this edition are an expanded theory section, expanded coverage of diversity issues, management and outcomes, and discussion of the impact of college on students. Part 1, "Historical Roots and Contemporary Context," includes chapters (1) "Historical…

  12. The Trouble with Maths: A Practical Guide to Helping Learners with Numeracy Difficulties, 2nd Edition

    ERIC Educational Resources Information Center

    Chinn, Steve

    2011-01-01

    Now in a second edition, the award-winning "The Trouble with Maths" offers important insights into the often confusing world of numeracy. By looking at learning difficulties in maths from several perspectives, including the language of mathematics, thinking styles and the demands of individual topics, this book offers a complete overview of the…

  13. The Newbery and Caldecott Awards: A Guide to the Medal and Honor Books. 2012 Edition

    ERIC Educational Resources Information Center

    ALA Editions, 2012

    2012-01-01

    Updated to include the 2012 award and honor books, this new edition of the annual guide to the Newbery and Caldecott awards gathers together the books deemed most distinguished in American children's literature and illustration since the inception of the renowned prizes. Librarians and teachers everywhere rely on this guidebook for quick reference…

  14. Challenging Science and Literacy Activities for K-9 Students - The Cricket Chronicles: Student Edition

    ERIC Educational Resources Information Center

    Matthews, Catherine E.

    2006-01-01

    This is an extensive integrated unit of study focused on that common and familiar insect-the cricket. In this edition, students are provided with more than 30 activities on crickets, which will help them learn science content and skills including: (1) Taxonomy; (2) Anatomy; (3) Ecology; (4) Mark and recapture techniques for estimating population…

  15. Handbook of Response to Intervention: The Science and Practice of Multi-Tiered Systems of Support, 2nd Edition

    ERIC Educational Resources Information Center

    Jimerson, Shane R., Ed.; Burns, Matthew K., Ed.; VanDerHeyden, Amanda M., Ed.

    2016-01-01

    The second edition of this essential handbook provides a comprehensive, updated overview of the science that informs best practices for the implementation of response to intervention (RTI) processes within Multi-Tiered Systems of Support (MTSS) to facilitate the academic success of all students. The volume includes insights from leading scholars…

  16. Understanding the Role of Today's School Principal: A Primer for Bridging Theory to Practice, Second Edition

    ERIC Educational Resources Information Center

    Kellough, Richard D.; Hill, Phillys

    2014-01-01

    The second edition of this handbook is an easily understood desk companion for new school principals and aspiring school leaders. The common-sense approach of the handbook guides new administrators through daily routines and challenges. In-service and university professionals, who provide coursework that includes a multi-topic overview of the…

  17. Educators Guide to Free Tapes, Scripts, and Transcriptions. Eighteenth Edition.

    ERIC Educational Resources Information Center

    Wittich, Walter A., Ed.; And Others

    This compendium lists 442 tapes, scripts, and transcriptions which are available free of cost to schools and libraries. Of these titles, 259 are new this year. Forty-one of the titles may be kept permanently by the user. Cassettes and videotapes are included in this edition for the first time. The items are listed by topics; accident prevention…

  18. The Inside Story [Learning Packages for Exploratory Career Education--7th and 8th Grades: Teacher and Student Editions.

    ERIC Educational Resources Information Center

    Kemp, Louie E., Comp.

    The four learning packages for exploratory career education are designed for use at the seventh and eighth grade levels. Each unit includes coordinated teacher and student editions. The units are: Culinary Cubs, focusing on occupations in the areas of food management, production, and services, with special reference to dietitians; Mini Nursery,…

  19. Test Review: C. D. Elliott "Differential Ability Scales-Second Edition." San Antonio, TX--Harcourt Assessment, 2007

    ERIC Educational Resources Information Center

    Marshall, Stephanie; McGoey, Kara E.; Moschos, Susan

    2011-01-01

    This article presents a review of the Differential Ability Scales-Second Edition (DAS-II), an individually administered cognitive test battery, designed to evaluate children ages 2 years 6 months to 17 years 11 months. It purports to measure a hierarchy of cognitive abilities, including broad abilities contributing to a single cognitive factor…

  20. The Demand for Water Transportation: Application of Discriminant Analysis to Commodities Shipped by Barge and Competing Modes in Ohio River and Arkansas River Areas.

    DTIC Science & Technology

    1980-08-01

    extended to include influence of time in transit, perishability, and uncertainty in market 7Alfred Marshall, Principles of Economics , 9th Edition (McMillan...the Maritime Administration, U.S. Department of Commerce, Washington, D.C. (1974). Marshall, Alfred. Principles of Economics . 9th Edition. :.[cMillian

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