Sample records for educator guide pdf

  1. Air Education and Training Command > Home

    Science.gov Websites

    Media Guide (PDF) USAF Social Media Sites Basic Training Technical Training AF Recruiting Service Flying Air Education and Training Command Air Education and Training Command Join the Air Force Home News Our Experts Search Air Education and Training Command: Continuum of Learning AETC Strategic Plan Ask

  2. Helping your child understand a cancer diagnosis

    MedlinePlus

    ... or movie together, or buy your child some comic books. Visit with other children who have had ... guide for parents. www.cancer.gov/publications/patient-education/children-with-cancer.pdf . Updated September 2015. Accessed ...

  3. Drug Safety - Multiple Languages

    MedlinePlus

    ... Expand Section Guide to Over the Counter Medications - English PDF Guide to Over the Counter Medications - Amarɨñña / ... Information Translations Guide to Over the Counter Medications - English PDF Guide to Over the Counter Medications - العربية ( ...

  4. Childhood Immunization - Multiple Languages

    MedlinePlus

    ... What to Do If Your Child Has Discomfort - English PDF After the Shots: What to Do If ... Coalition Immunizations for Babies: A Guide for Parents - English PDF Immunizations for Babies: A Guide for Parents - ...

  5. 77 FR 58991 - State-Level Guarantee Fee Pricing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-25

    .../relatedservicinginfo/pdf/foreclosuretimeframes.pdf and http://www.freddiemac.com/learn/pdfs/service/exhibit83.pdf . The... Relative to the National Average Estimated Cost per day Foreclosure average Total time to relative to Rank.../guides/ssg/relatedservicinginfo/pdf/foreclosuretimeframes.pdf and http://www.freddiemac.com/learn/pdfs...

  6. Staying Well

    MedlinePlus

    ... Brochure Vitamins, Minerals, and Herbs in MS: An Introduction (.pdf) Practical guide to diet supplements for people ... you Vitamins, Minerals, and Herbs in MS: An Introduction (.pdf) Download Brochure Taming Stress (.pdf) Download Brochure ...

  7. TES/Aura L3 Carbon Monoxide (CO) Monthly (TL3COM)

    Atmospheric Science Data Center

    2018-02-28

    ... TES Aura L1B Nadir Spatial Coverage:  5.3 x 8.5 km Spatial Resolution:  0.5 x 5 km ... Guide Documents:  Data User's Guide (PDF):  Level 3 Level 3 Algorithms, Requirements, & Products (PDF) ...

  8. TES/Aura L3 Nitric Acid (HNO3) Daily V4 (TL3HNOD)

    Atmospheric Science Data Center

    2018-02-28

    ... 37 x 23 km Spatial Resolution:  2.3 x 23 km Temporal Coverage:  08/22/2004 - 04/10/2005 ... Guide Documents:  Data User's Guide (PDF):  Level 3 Level 3 Algorithms, Requirements, & Products (PDF) ...

  9. TES/Aura L3 Methane (CH4) Monthly (TL3CH4M)

    Atmospheric Science Data Center

    2018-02-28

    ... TES Aura L1B Nadir Spatial Coverage:  5.3 x 8.5 km Spatial Resolution:  0.5 x 5 km ... Guide Documents:  Data User's Guide (PDF):  Level 3 Level 3 Algorithms, Requirements, & Products (PDF) ...

  10. Clinical outcomes of EUS-guided drainage of debris-containing pancreatic pseudocysts: a large multicenter study.

    PubMed

    Yang, Dennis; Amin, Sunil; Gonzalez, Susana; Mullady, Daniel; Edmundowicz, Steven A; DeWitt, John M; Khashab, Mouen A; Wang, Andrew Y; Nagula, Satish; Buscaglia, Jonathan M; Bucobo, Juan Carlos; Wagh, Mihir S; Draganov, Peter V; Stevens, Tyler; Vargo, John J; Khara, Harshit S; Diehl, David L; Keswani, Rajesh N; Komanduri, Srinadh; Yachimski, Patrick S; Prabhu, Anoop; Kwon, Richard S; Watson, Rabindra R; Goodman, Adam J; Benias, Petros; Carr-Locke, David L; DiMaio, Christopher J

    2017-02-01

    Background and study aims  Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with PDF vs. PSD undergoing endoscopic ultrasound (EUS)-guided drainage via transmural stents. Patients and methods  Retrospective review of 142 consecutive patients with pseudocysts who underwent EUS-guided transmural drainage (TM) from 2008 to 2014 at 15 academic centers in the United States. Main outcome measures included TM technical success, treatment outcomes (symptomatic and radiologic resolution), need for endoscopic re-intervention at follow-up, and adverse events (AEs). Results  TM was performed in 90 patients with PDF and 52 with PSD. Technical success: PDF 87 (96.7 %) vs. PSD 51 (98.1 %). There was no difference in the rates for endoscopic re-intervention (5.5 % in PDF vs. 11.5 % in PSD; P =  0.33) or AEs (12.2 % in PDF vs. 19.2 % in PSD; P  = 0.33). Median long-term follow-up after stent removal was 297 days (interquartile range [IQR]: 59 - 424 days) for PDF and 326 days (IQR: 180 - 448 days) for PSD ( P  = 0.88). There was a higher rate of short-term radiologic resolution of PDF (45; 66.2 %) vs. PSD (21; 51.2 %) (OR = 0.30; 95 % CI: 0.13 - 0.72; P  = 0.009). There was no difference in long-term symptomatic resolution (PDF: 70.4 % vs. PSD: 66.7 %; P  = 0.72) or radiologic resolution (PDF: 68.9 % vs. PSD: 78.6 %; P  = 0.72) Conclusions  There was no difference in need for endoscopic re-intervention, AEs or long-term treatment outcomes in patients with PDF vs. PSD undergoing EUS-guided drainage with transmural stents. Based on these results, the presence of solid debris in pancreatic fluid collections does not appear to be associated with a poorer outcome.

  11. TES/Aura L3 Ammonia (NH3) Daily V3 (TL3NH3D)

    Atmospheric Science Data Center

    2018-03-14

    ... TES Aura L1B Nadir Spatial Coverage:  5.3 x 8.5 km Spatial Resolution:  0.5 x 5 km ... Guide Documents:  Data User's Guide (PDF):  Level 3 Level 3 Algorithms, Requirements, & Products (PDF) ...

  12. Marine Mammal Stock Assessment Reports (SARs) by Region :: NOAA Fisheries

    Science.gov Websites

    Regional Fishery Management Councils Congress Activities Budget Testimony Educators and Students Education 2016 Pacific [pdf] Summary Table: 2016 Pacific [pdf] 2016 Atlantic [pdf] Summary Table: 2016 Atlantic [pdf] 2016 Alaska [pdf] Summary Table: 2016 Alaska [pdf] 2015 2015 Pacific [pdf] Summary Table: 2015

  13. A Partner's Guide to Pregnancy

    MedlinePlus

    ... For Patients About ACOG A Partner's Guide to Pregnancy Home For Patients Search FAQs A Partner's Guide ... May 2016 PDF Format A Partner's Guide to Pregnancy Pregnancy Why is it important to be supportive ...

  14. Chronic Obstructive Pulmonary Disease (COPD)

    MedlinePlus

    ... thoracic. org/ information- series/ en/ resources/ oxygen- therapy. pdf) . Breathlessness, however, will happen with COPD even if ... information- series/ en/ resources/ ATS_ Patient_ Ed_ Breathlessness. pdf) Breathlessness is therefore not a good guide for ...

  15. Toddler Nutrition: MedlinePlus Health Topic

    MedlinePlus

    ... in Spanish Healthy Eating for Preschoolers (Department of Agriculture) - PDF Also in Spanish Nutrition Guide for Toddlers ( ... 10 Tips for Setting Good Examples (Department of Agriculture) - PDF Also in Spanish Children's Nutrition: Tips for ...

  16. ACHP | Citizen's Guide to Section 106 Review

    Science.gov Websites

    print PDF files, you need the Adobe Acrobat Reader. Please visit Adobe to download the free Acrobat Reader. For conversion of PDF to HTML, visit Access Adobe's free conversion service. Return to Top

  17. NASA Scope and Subject Category Guide

    NASA Technical Reports Server (NTRS)

    2011-01-01

    This guide provides a simple, effective tool to assist aerospace information analysts and database builders in the high-level subject classification of technical materials. Each of the 76 subject categories comprising the classification scheme is presented with a description of category scope, a listing of subtopics, cross references, and an indication of particular areas of NASA interest. The guide also includes an index of nearly 3,000 specific research topics cross referenced to the subject categories. The portable document format (PDF) version of the guide contains links in the index from each input subject to its corresponding categories. In addition to subject classification, the guide can serve as an aid to searching databases that use the classification scheme, and is also an excellent selection guide for those involved in the acquisition of aerospace literature. The CD-ROM contains both HTML and PDF versions.

  18. Protect Yourself against Hepatitis A and B: A Guide for Gay and Bisexual Men

    MedlinePlus

    ... vaccineinformation.org www.immunize.org/catg.d/p4115.pdf • Item #P4115 (5/18) Protect Yourself Against Hepatitis ... vaccineinformation. org www. immunize. org/ catg. d/ p4115. pdf • Item #P4115 (5/18)

  19. The Reintegration of Tongan Postgraduate Scholars after Study Abroad: Knowledge Utilisation and Resituation

    ERIC Educational Resources Information Center

    Franken, Margaret; Langi, Nautalus Tuituiovai Kaho; Branson, Christopher

    2016-01-01

    Higher education has seen increasing educational mobility as students finance themselves or get financial support from their families to study abroad (Shields "Comp Educ Rev" 57(4):609-636, 2013; Verbik and Lazanowski in "World education news and reviews." http://www.wes.org/educators/pdf/StudentMobility.pdf, 2007). Another…

  20. NARSTO EPA SS NEW YORK AIR CHEM PM MET DATA

    Atmospheric Science Data Center

    2018-04-09

    NARSTO EPA SS NEW YORK AIR CHEM PM MET DATA Project Title:  NARSTO ... Nitrogen Oxides Ozone Surface Winds Air Temperature Humidity Solar Irradiance Particulate Matter ... Data Guide Documents:  New York Air Chem Guide CPM Summary Report  (PDF) Nitrate ...

  1. Commuter choice primer : an employer's guide to implementing effective commuter choice programs

    DOT National Transportation Integrated Search

    2003-01-01

    The Commuter Choice Primer is intended to be a concise, user-friendly reference guide for employers and transportation professionals to developing and implementing worksite commuter choice programs. It is available on-line in both HTML and PDF format...

  2. 76 FR 14572 - Federal Acquisition Regulation; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... Acquisition Regulations. List of Subjects in 48 CFR Parts 18, 19, and 52 Government procurement. Dated: March... in paragraph (b) by removing ``http:// www.whitehouse.gov/omb/procurement/guides/emergency_acquisitions_ guide.pdf'' and adding ``http://www.whitehouse.gov/sites/default/files/ omb/assets/procurement...

  3. NARSTO EPA SS LOS ANGELES PM25 NITRATE

    Atmospheric Science Data Center

    2018-04-09

    NARSTO EPA SS LOS ANGELES PM25 NITRATE Project Title:  NARSTO Discipline:  ... Order:   E arthdata Search Parameters:  Nitrate Particles Order Data:  Earthdata Search:   Order ... Guide Documents:  Los Angeles PM25 Nitrate Guide Los Angeles Project Plan  (PDF) Los ...

  4. A Detailed Study of Advection Sea Fog Formation to Reduce the Operational Impacts Along the Northern Gulf of Mexico

    DTIC Science & Technology

    2007-03-01

    From Mid-Air Collision Avoidance Pilot Education Program, Tyndall Air Force Base. http://www.tyndall.af.mil/ MACA /moamap.pdf Accessed 10 September...Collision Avoidance Pilot Education Program, Tyndall Air Force Base. http://www.tyndall.af.mil/ MACA /moamap.pdf Accessed 10 September 2006). 5...cited 2006: Tyndall Air Force Base. [Available online at http://www.tyndall.af.mil/ MACA /moamap.pdf]. Accessed 25 September 2006. Mid-Air Collision

  5. 75 FR 65652 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Certain Products Containing Interactive Program Guide and Parental Controls Technology, DN 2763; the... guide and parental controls technology. The complaint names as respondents Toshiba Corp. of Minato-ku.../handbook_on_electronic_filing.pdf ). Persons with questions regarding electronic filing should contact the...

  6. Assessing and Improving Student Organizations: Resources for Facilitators CD-ROM. The Assessing and Improving Student Organization (AISO) Program

    ERIC Educational Resources Information Center

    Nolfi, Tricia; Ruben, Brent D.

    2010-01-01

    This companion to the "Guide for Students" and "Student Workbook" includes the complete set of PowerPoint slides, a PDF of the Facilitator's Guide in PPT (PowerPoint) slide show format, and PDFs of all scoring sheets, handouts and project planning guides needed for the AISO (Assessing and Improving Student Organization) process. The Assessing and…

  7. The Human Proteome Project: Unlocking the Mysteries of Human Life and Unleashing Its Potential

    DTIC Science & Technology

    2011-02-16

    Australasian Genetics Resource Book. June 2007. Accessed September 27, 2010. www.genetics.com.au/pdf/factsheets/fs24.pdf. 2 White House, Office of...Project and Beyond." The Australasian Genetics Resource Book. June 2007. Accessed September 27, 2010. www.genetics.com.au/pdf/factsheets/fs24.pdf...9 Centre for Genetics Education. "The Human Genetic Code – The Human Genome Project and Beyond." The Australasian Genetics Resource Book. June

  8. 48 CFR 36.104 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Guiding Principles for Federal Leadership in High-Performance and Sustainable Buildings (available at http://www.wbdg.org/pdfs/hpsb_guidance.pdf); (2) Pursue cost-effective, innovative strategies, such as highly...

  9. United States Fire Administration

    MedlinePlus

    ... Vehicle Fire Safety flyer PDF 234 KB Publication Risk management practices This guide contains recommended approaches to manage organizational, operational and community risk. If you are a fire department leader, our ...

  10. 77 FR 49788 - National Committee on Foreign Medical Education and Accreditation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... official version of this document is the document published in the Federal Register. Free Internet access... Document Format (PDF). To use PDF, you must have Adobe Acrobat Reader, which is available free at the site...

  11. Child Mental Health: MedlinePlus Health Topic

    MedlinePlus

    ... Adolescent Psychiatry) Helping Children and Adolescents Cope with Violence and Disasters: What Parents Can Do (National Institute of Mental Health) Also in Spanish Partnering with Your Child's School: A Guide for Parents (HSC Foundation) - PDF Sleep ...

  12. Healthy Indoor Environment Protocols for Home Energy Upgrades

    EPA Pesticide Factsheets

    This page contains the EPA-developed Healthy Indoor Environment Protocols for Home Energy Upgrades, a PDF guide that provides a set of best practices for improving indoor air quality in conjunction with energy upgrade work in homes.

  13. Publications - PDF 98-37D | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in - Read me Keywords Coastal and River; Coastal and River Hazards; Construction Materials; Decorative Stone

  14. Stem Cell Treatments: What to Ask

    MedlinePlus

    ... many haven’t? Have your findings been published? Patient rights What are my rights as a participant—for ... any new information that might come up, my right to withdraw from the treatment ... Patient Handbook (PDF) Download a guide to help you ...

  15. Simplified generation of biomedical 3D surface model data for embedding into 3D portable document format (PDF) files for publication and education.

    PubMed

    Newe, Axel; Ganslandt, Thomas

    2013-01-01

    The usefulness of the 3D Portable Document Format (PDF) for clinical, educational, and research purposes has recently been shown. However, the lack of a simple tool for converting biomedical data into the model data in the necessary Universal 3D (U3D) file format is a drawback for the broad acceptance of this new technology. A new module for the image processing and rapid prototyping framework MeVisLab does not only provide a platform-independent possibility to create surface meshes out of biomedical/DICOM and other data and to export them into U3D--it also lets the user add meta data to these meshes to predefine colors and names that can be processed by a PDF authoring software while generating 3D PDF files. Furthermore, the source code of the respective module is available and well documented so that it can easily be modified for own purposes.

  16. ES4 Terra+Aqua Ed4

    Atmospheric Science Data Center

    2018-06-26

    ... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES4 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications.  SCAR-B Block:  ...

  17. ES4 Aqua-Xtrk Ed4

    Atmospheric Science Data Center

    2018-06-27

    ... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES4 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications.  SCAR-B Block:  ...

  18. ES4 Terra-Xtrk Ed4

    Atmospheric Science Data Center

    2018-06-27

    ... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES4 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications.  SCAR-B Block:  ...

  19. ES9 Terra-Xtrk Ed4

    Atmospheric Science Data Center

    2018-06-27

    ... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES9 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications. SCAR-B Block:  ...

  20. ES9 Aqua-Xtrk Ed4

    Atmospheric Science Data Center

    2018-06-27

    ... Detailed CERES ERBElike Level 3 (ES-4/ES-9) Product Information Collection Guide:  ES9 CG R1V1  (PDF) Data ... Edition2 for TRMM; and Edition1 for NPP) are approved for science publications. SCAR-B Block:  ...

  1. Phase processing for quantitative susceptibility mapping of regions with large susceptibility and lack of signal.

    PubMed

    Fortier, Véronique; Levesque, Ives R

    2018-06-01

    Phase processing impacts the accuracy of quantitative susceptibility mapping (QSM). Techniques for phase unwrapping and background removal have been proposed and demonstrated mostly in brain. In this work, phase processing was evaluated in the context of large susceptibility variations (Δχ) and negligible signal, in particular for susceptibility estimation using the iterative phase replacement (IPR) algorithm. Continuous Laplacian, region-growing, and quality-guided unwrapping were evaluated. For background removal, Laplacian boundary value (LBV), projection onto dipole fields (PDF), sophisticated harmonic artifact reduction for phase data (SHARP), variable-kernel sophisticated harmonic artifact reduction for phase data (V-SHARP), regularization enabled sophisticated harmonic artifact reduction for phase data (RESHARP), and 3D quadratic polynomial field removal were studied. Each algorithm was quantitatively evaluated in simulation and qualitatively in vivo. Additionally, IPR-QSM maps were produced to evaluate the impact of phase processing on the susceptibility in the context of large Δχ with negligible signal. Quality-guided unwrapping was the most accurate technique, whereas continuous Laplacian performed poorly in this context. All background removal algorithms tested resulted in important phase inaccuracies, suggesting that techniques used for brain do not translate well to situations where large Δχ and no or low signal are expected. LBV produced the smallest errors, followed closely by PDF. Results suggest that quality-guided unwrapping should be preferred, with PDF or LBV for background removal, for QSM in regions with large Δχ and negligible signal. This reduces the susceptibility inaccuracy introduced by phase processing. Accurate background removal remains an open question. Magn Reson Med 79:3103-3113, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  2. Making change easy: A peer-to-peer guide on transitioning to new hand hygiene products.

    PubMed

    Amirov, Chingiz M; Candon, Heather L; Jacob, Latha

    2017-01-01

    This report summarizes our experiences planning and implementing the transition to a new commercial line of hand hygiene products and their dispensing systems in a large academic health care facility in Toronto, Canada. Our lessons learned are organized into a practical guide made available in 2 different formats: this article and an illustrated peer-to-peer guide (http://www.baycrest.org/wp-content/uploads/HCE-PROG-HH_HighQuality.pdf). Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  3. Magnetic discontinuities in magnetohydrodynamic turbulence and in the solar wind.

    PubMed

    Zhdankin, Vladimir; Boldyrev, Stanislav; Mason, Joanne; Perez, Jean Carlos

    2012-04-27

    Recent measurements of solar wind turbulence report the presence of intermittent, exponentially distributed angular discontinuities in the magnetic field. In this Letter, we study whether such discontinuities can be produced by magnetohydrodynamic (MHD) turbulence. We detect the discontinuities by measuring the fluctuations of the magnetic field direction, Δθ, across fixed spatial increments Δx in direct numerical simulations of MHD turbulence with an imposed uniform guide field B(0). A large region of the probability density function (pdf) for Δθ is found to follow an exponential decay, proportional to exp(-Δθ/θ(*)), with characteristic angle θ(*)≈(14°)(b(rms)/B(0))(0.65) for a broad range of guide-field strengths. We find that discontinuities observed in the solar wind can be reproduced by MHD turbulence with reasonable ratios of b(rms)/B(0). We also observe an excess of small angular discontinuities when Δx becomes small, possibly indicating an increasing statistical significance of dissipation-scale structures. The structure of the pdf in this case closely resembles the two-population pdf seen in the solar wind. We thus propose that strong discontinuities are associated with inertial-range MHD turbulence, while weak discontinuities emerge from dissipation-range turbulence. In addition, we find that the structure functions of the magnetic field direction exhibit anomalous scaling exponents, which indicates the existence of intermittent structures.

  4. Constraints on the Profiles of Total Water PDF in AGCMs from AIRS and a High-Resolution Model

    NASA Technical Reports Server (NTRS)

    Molod, Andrea

    2012-01-01

    Atmospheric general circulation model (AGCM) cloud parameterizations generally include an assumption about the subgrid-scale probability distribution function (PDF) of total water and its vertical profile. In the present study, the Atmospheric Infrared Sounder (AIRS) monthly-mean cloud amount and relative humidity fields are used to compute a proxy for the second moment of an AGCM total water PDF called the RH01 diagnostic, which is the AIRS mean relative humidity for cloud fractions of 0.1 or less. The dependence of the second moment on horizontal grid resolution is analyzed using results from a high-resolution global model simulation.The AIRS-derived RH01 diagnostic is generally larger near the surface than aloft, indicating a narrower PDF near the surface, and varies with the type of underlying surface. High-resolution model results show that the vertical structure of profiles of the AGCM PDF second moment is unchanged as the grid resolution changes from 200 to 100 to 50 km, and that the second-moment profiles shift toward higher values with decreasing grid spacing.Several Goddard Earth Observing System, version 5 (GEOS-5), AGCM simulations were performed with several choices for the profile of the PDF second moment. The resulting cloud and relative humidity fields were shown to be quite sensitive to the prescribed profile, and the use of a profile based on the AIRS-derived proxy results in improvements relative to observational estimates. The AIRS-guided total water PDF profiles, including their dependence on underlying surface type and on horizontal resolution, have been implemented in the version of the GEOS-5 AGCM used for publicly released simulations.

  5. U.S. ENVIRONMENTAL PROTECTION AGENCY'S ECOLOGICAL RESEARCH STRATEGY

    EPA Science Inventory

    EPA's Office of Research and Development (ORD) has recently released a research strategy to guide its program to improve ecosystem risk assessment and risk management, which is one of the Agency's higheset priority search areas (http://www.epa.gov/ORD/WebPubs/fmal/eco.pdf). It is...

  6. 76 FR 29227 - Funding Down Slate; Indian Education Professional Development Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... this document is the document published in the Federal Register. Free Internet access to the official... free, at 1-800-877-8339. Individuals with disabilities can obtain this document in an accessible format... (PDF). To use PDF you must have Adobe Acrobat Reader, which is available free at the site. You may also...

  7. Pharmacogenomics Fact Sheet

    MedlinePlus

    ... News & Meetings Science Education About NIGMS NIGMS Home > Science Education > Pharmacogenomics Pharmacogenomics Tagline (Optional) Middle/Main Content Area PDF Version (376 KB) Other Fact Sheets What is pharmacogenomics? Pharmacogenomics (sometimes called pharmacogenetics) ...

  8. Designing for Education: Compendium of Exemplary Educational Facilities 2011

    ERIC Educational Resources Information Center

    OECD Publishing (NJ3), 2011

    2011-01-01

    "Designing for Education: Compendium of Exemplary Educational Facilities 2011" showcases over 60 recently built or refurbished educational facilities from 28 countries. Collectively, these projects demonstrate state-of-the-art design in this field and each one is lavishly illustrated with colour photos, plans and descriptions. [A free PDF is…

  9. Trauma Fact Sheet

    MedlinePlus

    ... News & Meetings Science Education About NIGMS NIGMS Home > Science Education > Physical Trauma Physical Trauma Tagline (Optional) Middle/Main Content Area PDF Version (420 KB) Other Fact Sheets What is physical trauma? Physical trauma is ...

  10. Assisted Vaginal Delivery

    MedlinePlus

    ... Patient Education FAQs Assisted Vaginal Delivery Patient Education Pamphlets - Spanish Assisted Vaginal Delivery FAQ192, February 2016 PDF ... on Patient Safety For Patients Patient FAQs Spanish Pamphlets Teen Health About ACOG About Us Leadership & Governance ...

  11. Sepsis Fact Sheet

    MedlinePlus

    ... News & Meetings Science Education About NIGMS NIGMS Home > Science Education > Sepsis Sepsis Tagline (Optional) Middle/Main Content Area PDF Version (392 KB) En español Other Fact Sheets What is sepsis? Sepsis is a serious ...

  12. Anesthesia Fact Sheet

    MedlinePlus

    ... News & Meetings Science Education About NIGMS NIGMS Home > Science Education > Anesthesia Anesthesia Tagline (Optional) Middle/Main Content Area En español PDF Version (464 KB) Other Fact Sheets What is anesthesia? Anesthesia is a medical ...

  13. Public Scoping Meeting Materials

    Science.gov Websites

    project and web site. your e-mail address Sign Me Up Search: OK Button DUF6 Guide DU Uses DUF6 Management , presentations, and other information from the Conversion EIS Public Scoping Meetings. The following materials ) Management Program 5.97 MB details DUF6 Fact Sheets PDF Icon Overview of Depleted Uranium Hexafluoride

  14. ISCCP-D2like-GEO Ed3A

    Atmospheric Science Data Center

    2018-05-16

    ISCCP-D2like-GEO Ed3A Project Title:  CERES Discipline:  ... Order Data Guide Documents:  GEO Description/Abstract Detailed CERES ISCCP-D2like Product ... Data Products Catalog:  DPC_ISCCP-D2like-GEO_R5V3  (PDF) Readme Files:  Readme GEO R5-987 ...

  15. EBooks as PDF Files, in EPub Format or as Interactive IBooks? Digital Books in Physics Lessons of Secondary Education

    ERIC Educational Resources Information Center

    Lohr, Manfred

    2014-01-01

    This paper outlines the different capabilities of ebooks in the pdf, epub and ibook format in science teaching evaluated at the BG/BRG Schwechat. Over the recent years the school equipped with 100 personal computers and 28 iPads has become one of the leading e-learning schools in Austria. iPads show their advantages in the context of blended…

  16. 75 FR 61138 - Committee on Measures of Student Success

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... Education Statistics, Institute of Education Sciences, Department of Education. ACTION: Notice of an open... following site: http://www.ed.gov/news/fed-register/index.html . To use PDF you must have Adobe Acrobat..., Institute of Education Sciences. [FR Doc. 2010-24782 Filed 10-1-10; 8:45 am] BILLING CODE 4000-01-P ...

  17. 76 FR 2674 - Committee on Measures of Student Success

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Education Statistics, Institute of Education Sciences, Department of Education. ACTION: Notice of an open... following site: http://www.ed.gov/news/fed-register/index.html . To use PDF you must have Adobe Acrobat..., Institute of Education Sciences. [FR Doc. 2011-800 Filed 1-13-11; 8:45 am] BILLING CODE 4000-01-P ...

  18. Guides, Tools, and Clearinghouses: A Presentation of Resources for Scientists Involved in Education and Public Outreach

    NASA Astrophysics Data System (ADS)

    Grier, Jennifer A.; Buxner, Sanlyn; Meinke, Bonnie; Gross, Nick; Woroner, Morgan

    2014-11-01

    The NASA Science Mission Directorate (SMD) Education Forums help scientists with their engagement in education and public outreach (E/PO) activities. The Forums provide professional development, resources, as well as opportunities to interact with the larger E/PO community. We have conducted both interviews and surveys of space scientists regarding their needs and attitudes about E/PO. The most recent of these was a series of semi-structured interviews with two-dozen DPS members, which allowed the Forums to identify those areas where new or additional resources and support are needed for scientists regarding their E/PO involvement. This poster will present key resources that scientists can use to learn more about the nature of E/PO, how to become involved, how to leverage their efforts, how to find effective and vetted demonstrations and activities, and where to go to make the most impact. The first two of an upcoming series of one-page guides includes “The Quick Introduction to Education and Public Outreach” as well as “Making the Most of Your E/PO Time - Increasing your Efficiency and Impact.” http://smdepo.org/post/7202. The Planetary Science Education and Public Outreach Resource Sampler offers a list of activities specifically selected for quick access and ease of use. These resources are organized by major science questions, and then by topics such as “Impacts in the Solar System,” “Windy Worlds,” and “Scale in the Solar System.” http://smdepo.org/data/uploads/PS_EPO_Resources_2.pdf Wavelength is a repository of resources for learning at all levels, from outreach programs and after school to formal K-college. All activities held within Wavelength have passed the NASA SMD peer-review for products, ensuring that each has sound content both in science and education. http://nasawavelength.org. The poster will also present the SMD Speaker’s Bureau, Community Workspace, and resources developed by partners, such as the AAS Ambassador Program’s MOOSE, Menu of Outreach Opportunities for Science Education http://aas.org/outreach/moose-menu-outreach-opportunities-science-education.

  19. Citizen Airman Magazine > Home

    Science.gov Websites

    Past Issues Social Media Twitter Logo Youth aviation event sparks new energy - https://t.co/TJG3nKAs4D ! Just getting things setup! Facebook 76 Like Us Twitter 278 Follow Us YouTube Blog RSS Air Force Social Media Guide (PDF) USAF Social Media Sites About AFRC AFR Mission Briefing Mission Briefing AFR Snapshot

  20. Business Continuity Management Plan

    DTIC Science & Technology

    2014-12-01

    organization ( Shaw , 2004). Navy Supply Systems Command (NAVSUP) does not have a framework that can help develop a business continuity management (BCM...cites two case studies that demonstrate how an organization mitigated issues during catastrophic events that led to disruptions to their business ...www.uschamber.com/sites/default/files/legacy/ issues /defense/files/guideli nesbc.pdf Comprehensive Emergency Management Associates. (2006). Business continuity

  1. Letter to the Editor

    NASA Astrophysics Data System (ADS)

    2000-01-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Looking back on Physics Peter Gill Lecturer in Education, School of Education, King's College London, Franklin-Wilkins Building, Waterloo Road, London SE1 8WA

  2. Ideas and Inspirations: Good News about Diabetes Prevention and Management in Indian Country

    MedlinePlus

    ... Combined Councils Patient Education Primary Care Provider Risk Management Veteran Resources Community Health Behavioral Health Environmental Health ... Tools Diabetes Education Lesson Plan Outlines Integrating Case Management Into Your Practice [PDF – 290 KB] Integrating DSMES ...

  3. 36 CFR 1233.16 - How does an agency transfer records to the National Personnel Records Center (NPRC)?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-1800, Web site http://www.opm.gov/feddata/recguide2008.pdf, for the OPM publication “The Guide to... Records Center (NPRC), St. Louis, MO” section of the NARA Federal Records Centers Program Web site (http... assistance consult the NPRC Web site (http://www.archives.gov/facilities/mo/st7_louis.html). ...

  4. Gum Disease - Multiple Languages

    MedlinePlus

    ... Русский) Somali (Af-Soomaali ) Spanish (español) Ukrainian (українська ) Vietnamese (Tiếng Việt) HealthReach resources will open in a ... Gingivitis - українська (Ukrainian) Bilingual PDF Health Information Translations Vietnamese (Tiếng Việt) Expand Section Gum Disease: A Guide ...

  5. Home of the 151st Air Refueling Wing

    Science.gov Websites

    Air Force aerial porters RSS More Social Media Facebook Logo Congratulations to Hailee and Danny social media sites! But in doing so, let's practice good Social Med... https://t.co/NcqQji3diJ Facebook Flickr Air Force Social Media Guide (PDF) USAF Social Media Sites SAPR Sexual Assault Prevention and

  6. 36 CFR § 1233.16 - How does an agency transfer records to the National Personnel Records Center (NPRC)?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-1800, Web site http://www.opm.gov/feddata/recguide2008.pdf, for the OPM publication “The Guide to... Records Center (NPRC), St. Louis, MO” section of the NARA Federal Records Centers Program Web site (http... assistance consult the NPRC Web site (http://www.archives.gov/facilities/mo/st_louis.html). ...

  7. 36 CFR 1233.16 - How does an agency transfer records to the National Personnel Records Center (NPRC)?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-1800, Web site http://www.opm.gov/feddata/recguide2008.pdf, for the OPM publication “The Guide to... Records Center (NPRC), St. Louis, MO” section of the NARA Federal Records Centers Program Web site (http... assistance consult the NPRC Web site (http://www.archives.gov/facilities/mo/st_louis.html). ...

  8. Great Lakes Literacy Principles

    NASA Astrophysics Data System (ADS)

    Fortner, Rosanne W.; Manzo, Lyndsey

    2011-03-01

    Lakes Superior, Huron, Michigan, Ontario, and Erie together form North America's Great Lakes, a region that contains 20% of the world's fresh surface water and is home to roughly one quarter of the U.S. population (Figure 1). Supporting a $4 billion sport fishing industry, plus $16 billion annually in boating, 1.5 million U.S. jobs, and $62 billion in annual wages directly, the Great Lakes form the backbone of a regional economy that is vital to the United States as a whole (see http://www.miseagrant.umich.edu/downloads/economy/11-708-Great-Lakes-Jobs.pdf). Yet the grandeur and importance of this freshwater resource are little understood, not only by people in the rest of the country but also by many in the region itself. To help address this lack of knowledge, the Centers for Ocean Sciences Education Excellence (COSEE) Great Lakes, supported by the U.S. National Science Foundation and the National Oceanic and Atmospheric Administration, developed literacy principles for the Great Lakes to serve as a guide for education of students and the public. These “Great Lakes Literacy Principles” represent an understanding of the Great Lakes' influences on society and society's influences on the Great Lakes.

  9. Terrorism 101 - Knowledge about the What and Why of Terrorism as a State and Local Law Enforcement Competency

    DTIC Science & Technology

    2008-09-01

    Zimbardo, “How Social Science can Reduce Terrorism,” The Chronicle of Higher Education (2004), http://www.socialpsychology.org/ pdf /chronicle04. pdf ...the children of Satan ; believers must prepare for the second coming of Yahweh by taking action “Religious” is one of five “motivations...Christian Identity Groups – Christian Bible is used to justify reasons behind beliefs • U.S. Constitution is extension of Bible • Philosophy is based

  10. Environmental Acoustic Considerations for Passive Detection of Maritime Targets by Hydrophones in a Deep Ocean Trench

    DTIC Science & Technology

    2010-06-01

    Science and Technology. Available: http://cmst.curtin.edu.au/local/docs/ products / actup_v2_2l_installation_user_guide.pdf (accessed 2 June 2010...noisecurve112(:,6)); %% Intergrating Noise Level Trench A n2=0; Itot=0; phi_t=atan(D1/L1); m=1; while (phi(m,1)>phi_t) m=m+1; end

  11. Subcutaneous (SQ) injections

    MedlinePlus

    ... education/pepubs/subq.pdf . Accessed January 2, 2018. Smith SF, Duell DJ, Martin BC, Gonzalez L, Aebersold M. Medication administration. In: Smith SF, Duell DJ, Martin BC, Gonzalez L, Aebersold ...

  12. What about Breastfeeding?

    MedlinePlus

    ... Fundraising Ideas Vehicle Donation Volunteer Efforts What about Breastfeeding? skip to submenu What We Do Cleft & Craniofacial Educational Materials What about Breastfeeding? To download the PDF version of this factsheet, ...

  13. DiTour

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pelaia, II, Thomas A.

    2014-06-05

    it is common for facilities to have a lobby with a display loop while also requiring an option for guided tours. Existing solutions have required expensive hardware and awkward software. Our solution is relative low cost as it runs on an iPad connected to an external monitor, and our software provides an intuitive touch interface. The media files are downloaded from a web server onto the device allowing a mobile option (e.g. displays at conferences). Media may include arbitrary sequences of images, movies or PDF documents. Tour guides can select different tracks of slides to display and the presentation willmore » return to the default loop after a timeout.« less

  14. Smart Location Database - Service

    EPA Pesticide Factsheets

    The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block group in the United States. Future updates to the SLD will include additional attributes which summarize the relative location efficiency of a block group when compared to other block groups within the same metropolitan region. EPA also plans to periodically update attributes and add new attributes to reflect latest available data. A log of SLD updates is included in the SLD User Guide. See the user guide for a full description of data sources, data currency, and known limitations: https://edg.epa.gov/data/Public/OP/SLD/SLD_userguide.pdf

  15. Smart Location Database - Download

    EPA Pesticide Factsheets

    The Smart Location Database (SLD) summarizes over 80 demographic, built environment, transit service, and destination accessibility attributes for every census block group in the United States. Future updates to the SLD will include additional attributes which summarize the relative location efficiency of a block group when compared to other block groups within the same metropolitan region. EPA also plans to periodically update attributes and add new attributes to reflect latest available data. A log of SLD updates is included in the SLD User Guide. See the user guide for a full description of data sources, data currency, and known limitations: https://edg.epa.gov/data/Public/OP/SLD/SLD_userguide.pdf

  16. Books and Other Resources for Education about the August 21, 2017, Solar Eclipse

    NASA Astrophysics Data System (ADS)

    Pasachoff, Jay M.; Fraknoi, Andrew; Kentrianakis, Michael

    2017-06-01

    As part of our work to reach and educate the 300+ million Americans of all ages about observing the August 21 solar eclipse, especially by being outdoors in the path of totality but also for those who will see only partial phases, we have compiled annotated lists of books, pamphlets, travel guides, websites, and other information useful for teachers, students, and the general public and made them available on the web, at conferences, and through webinars. Our list includes new eclipse books by David Barron, Anthony Aveni, Frank Close, Tyler Nordgren, John Dvorak, Michael Bakich, and others. We list websites accessible to the general public including those of the International Astronomical Union Working Group on Eclipses (http://eclipses.info, which has links to all the sites listed below); the AAS Eclipse 2017 Task Force (http://eclipse2017.aas.org); NASA Heliophysics (http://eclipse.nasa.gov); Fred Espenak (the updated successor to his authoritative "NASA website": http://EclipseWise.com); Michael Zeiler (http://GreatAmericanEclipse.com); Xavier Jubier (http://xjubier.free.fr/en/site_pages/solar_eclipses/); Jay Anderson (meteorology: http://eclipsophile.com); NASA's Eyes (http://eyes.nasa.gov/eyes-on-eclipse.html and its related app); the Astronomical Society of the Pacific (http://www.astrosociety.org/eclipse); Dan McGlaun (http://eclipse2017.org/); Bill Kramer (http://eclipse-chasers.com). Specialized guides include Dennis Schatz and Andrew Fraknoi's Solar Science for teachers (from the National Science Teachers Association:http://www.nsta.org/publications/press/extras/files/solarscience/SolarScienceInsert.pdf), and a printing with expanded eclipse coverage of Jay Pasachoff's, Peterson Field Guide to the Stars and Planets (14th printing of the fourth edition, 2016: http://solarcorona.com).A version of our joint list is to be published in the July issue of the American Journal of Physics as a Resource Letter on Eclipses, adding to JMP's 2010, "Resource Letter SP-1 on Solar Physics," AJP, 78, September, 890-901.

  17. A Sampling-Based Bayesian Approach for Cooperative Multiagent Online Search With Resource Constraints.

    PubMed

    Xiao, Hu; Cui, Rongxin; Xu, Demin

    2018-06-01

    This paper presents a cooperative multiagent search algorithm to solve the problem of searching for a target on a 2-D plane under multiple constraints. A Bayesian framework is used to update the local probability density functions (PDFs) of the target when the agents obtain observation information. To obtain the global PDF used for decision making, a sampling-based logarithmic opinion pool algorithm is proposed to fuse the local PDFs, and a particle sampling approach is used to represent the continuous PDF. Then the Gaussian mixture model (GMM) is applied to reconstitute the global PDF from the particles, and a weighted expectation maximization algorithm is presented to estimate the parameters of the GMM. Furthermore, we propose an optimization objective which aims to guide agents to find the target with less resource consumptions, and to keep the resource consumption of each agent balanced simultaneously. To this end, a utility function-based optimization problem is put forward, and it is solved by a gradient-based approach. Several contrastive simulations demonstrate that compared with other existing approaches, the proposed one uses less overall resources and shows a better performance of balancing the resource consumption.

  18. Accessible and informative sectioned images, color-coded images, and surface models of the ear.

    PubMed

    Park, Hyo Seok; Chung, Min Suk; Shin, Dong Sun; Jung, Yong Wook; Park, Jin Seo

    2013-08-01

    In our previous research, we created state-of-the-art sectioned images, color-coded images, and surface models of the human ear. Our ear data would be more beneficial and informative if they were more easily accessible. Therefore, the purpose of this study was to distribute the browsing software and the PDF file in which ear images are to be readily obtainable and freely explored. Another goal was to inform other researchers of our methods for establishing the browsing software and the PDF file. To achieve this, sectioned images and color-coded images of ear were prepared (voxel size 0.1 mm). In the color-coded images, structures related to hearing, equilibrium, and structures originated from the first and second pharyngeal arches were segmented supplementarily. The sectioned and color-coded images of right ear were added to the browsing software, which displayed the images serially along with structure names. The surface models were reconstructed to be combined into the PDF file where they could be freely manipulated. Using the browsing software and PDF file, sectional and three-dimensional shapes of ear structures could be comprehended in detail. Furthermore, using the PDF file, clinical knowledge could be identified through virtual otoscopy. Therefore, the presented educational tools will be helpful to medical students and otologists by improving their knowledge of ear anatomy. The browsing software and PDF file can be downloaded without charge and registration at our homepage (http://anatomy.dongguk.ac.kr/ear/). Copyright © 2013 Wiley Periodicals, Inc.

  19. Maxwell Air Force Base

    Science.gov Websites

    Social Media Guide (PDF) USAF Social Media Sites 42nd Medical Group 42nd Medical Group Voting Assistance : Open 24 hours a day, seven days a week. - Kelly St. Gate: Open Mon-Fri, 6:00 a.m. - 6 p.m., closed weekends, holidays and AETC down days. - Day St. Gate: Open Mon-Fri, 6:00 a.m. - 2:00 p.m. inbound traffic

  20. Postpartum Depression

    MedlinePlus

    ... Education & Events Advocacy For Patients About ACOG Postpartum Depression Home For Patients Search FAQs Postpartum Depression Page ... Postpartum Depression FAQ091, December 2013 PDF Format Postpartum Depression Labor, Delivery, and Postpartum Care What are the ...

  1. Getting a Job: Educators' Guides and Supporting Documents

    ERIC Educational Resources Information Center

    PEPNet 2, 2013

    2013-01-01

    This paper presents a collection of videos that provide ideas on getting jobs for educators. Contents include: (1) Educator's Guide: Introduction to the Video Series; (2) Educator's Guide: Your Journey; (3) Educator's Guide: Your Rights and Responsibilities; (4) Educator's Guide: Introduction to Vocational Rehabilitation; (5) Educator's Guide:…

  2. The Advanced Security Operations Corporation Special Weapons and Tactics Initiative: A Business Plan

    DTIC Science & Technology

    2004-12-01

    5 Kotler , Philip . (2003). A Framework for Marketing Management (2nd ed.). New Jersey: Pearson Education. 8 teams in Los...www.ojp.usdoj.gov/odp/docs/fy04hsgp_appkit.pdf 5. Kotler , Philip . (2003). A Framework for Marketing Management (2nd ed.). New Jersey: Pearson Education. 6

  3. There is a strong need for a single unified textbook even though education in disaster mitigation covers many fields

    NASA Astrophysics Data System (ADS)

    Sugimoto, M.; Song, Y.

    2015-12-01

    Areas of scientific specialties have been segmentalized nowadays. Each natural hazard are researched by scientific researchers. A huge variety of textbooks on one or few natural hazard are published by a single researcher in the world. There are possibilities are several natural disaster in one place. People have to learn from each hazard. However such disaster textbook is not unified education publish. Education in disaster mitigation covers many fields. There is a strong need for a single unified textbook. When I teach disaster education to children in kindergartens and schools, I understand students are confused by each different direction in such textbooks. "Doctor, which is right when a earthquake happens, cover my head or go out of a building? " I would like to discuss what the most valuable disaster textbook is as my following disatser handbook with audiences. This is publisehd for developping countries. You can freely download UNESCO disaster handbook following URL:http://www.icharm.pwri.go.jp/publication/pdf/handbook_on_local_disaster_management_experiences.pdf

  4. One Family's Struggles with Rotavirus

    MedlinePlus Videos and Cool Tools

    ... kids estate planning find a doctor find health information helpful articles antibiotics colds fevers injection tips sports ... Transcripts Full-length transcript PDF Important disclaimer : The information on pkids.org is for educational purposes only ...

  5. One Family's Struggle with Chickenpox

    MedlinePlus Videos and Cool Tools

    ... kids estate planning find a doctor find health information helpful articles antibiotics colds fevers injection tips sports ... Transcripts Full-length transcript PDF Important disclaimer : The information on pkids.org is for educational purposes only ...

  6. One Family's Struggles with Pertussis (Whooping Cough)

    MedlinePlus Videos and Cool Tools

    ... kids estate planning find a doctor find health information helpful articles antibiotics colds fevers injection tips sports ... Transcripts Full-length transcript PDF Important disclaimer : The information on pkids.org is for educational purposes only ...

  7. One Family's Struggles with Hepatitis B

    MedlinePlus Videos and Cool Tools

    ... kids estate planning find a doctor find health information helpful articles antibiotics colds fevers injection tips sports ... Transcripts Full-length transcript PDF Important disclaimer : The information on pkids.org is for educational purposes only ...

  8. One Family's Struggles with HPV (Human Papillomavirus)

    MedlinePlus Videos and Cool Tools

    ... kids estate planning find a doctor find health information helpful articles antibiotics colds fevers injection tips sports ... Transcripts Full-length transcript PDF Important disclaimer : The information on pkids.org is for educational purposes only ...

  9. Germs and Hygiene: MedlinePlus Health Topic

    MedlinePlus

    ... Foundation for Medical Education and Research) Also in Spanish Hygiene Fast Facts: Information on Water-Related Hygiene ( ... for Disease Control and Prevention) - PDF Also in Spanish Prevention and Risk Factors Eight Ways to Guard ...

  10. Briefing on New Zealand Canterbury Earthquake

    Science.gov Websites

    products laboratories publications nisee b.i.p. members education FAQs links events Calendar of PEER and Inc. Performance of Unreinforced Masonry and Selected Modern Buildings and Port Facilities (pdf file

  11. Fact Sheets

    MedlinePlus

    ... PDF Cytomegalovirus (CMV) PDF | Espanol PDF Escherichia coli (E. coli) PDF | Espanol PDF Fifth Disease (parvovirus B19) PDF | Espanol PDF Hepatitis A and the Vaccine PDF | Espanol PDF HPV Vaccine PDF | ... | Espanol PDF E-cigarettes (Vaping) PDF | Espanol PDF Heroin PDF | Espanol ...

  12. Potential Implications of Changes in ChalleNGe Admission Criteria: A Literature Review

    DTIC Science & Technology

    2015-04-01

    experiment, Steele, Spencer , and Aronson (2002) administered a 25- minute section of the math GRE [58]. Some women were given a “stereotype-threat...final.pdf. [31] Uguroglu, Margaret E., and Herbert J. Walberg. 1979. “Motivation and Achievement: A Quantitative Synthesis.” American Educational...Analysis of Educational Productivity.” Education Economics 7 (3): 199-208. [58] Steele, Claude M., Steven J. Spencer , and Joshua Aronson. 2002

  13. The TeleEducation NB Programme Development Fund Report, 1993-1998.

    ERIC Educational Resources Information Center

    McGreal, Rory

    The Programme Development Fund (PDF) was created to fund the design of distance education courses and programs in New Brunswick. Of the 132 projects funded, 23 were awarded to the private sector, 31 to community colleges, 62 to universities, 12 to non-profit organizations, and 4 to secondary schools. In addition to newly created jobs and the…

  14. Working during cancer treatment

    MedlinePlus

    ... cancer treatment. www.cancer.gov/publications/patient-education/life-after-treatment.pdf . Updated May 2014. Accessed October 12, 2016. Review Date 8/15/2016 Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review ...

  15. Physical Activity | NIH MedlinePlus the Magazine

    MedlinePlus

    ... pdf Child Nutrition: https://medlineplus.gov/childnutrition.html Secrets to Making School Lunches Kids Won't Want ... gov/health/educational/wecan/news-events/matte14.htm Secrets to Making Healthy and Fun School Lunches: http:// ...

  16. Vaginal Bleeding: MedlinePlus Health Topic

    MedlinePlus

    ... Bleeding (American Academy of Family Physicians) Also in Spanish Abnormal Uterine Bleeding (Beyond the Basics) (UpToDate) Abnormal ... College of Obstetricians and Gynecologists) - PDF Also in Spanish Vaginal Bleeding (Mayo Foundation for Medical Education and ...

  17. Do Interactive Globes and Games Help Students Learn Planetary Science?

    NASA Astrophysics Data System (ADS)

    Coba, Filis; Burgin, Stephen; De Paor, Declan; Georgen, Jennifer

    2016-01-01

    The popularity of animations and interactive visualizations in undergraduate science education might lead one to assume that these teaching aids enhance student learning. We tested this assumption for the case of the Google Earth virtual globe with a comparison of control and treatment student groups in a general education class of over 370 students at a large public university. Earth and Planetary Science course content was developed in two formats: using Keyhole Markup Language (KML) to create interactive tours in Google Earth (the treatment group) and Portable Document Format (PDF) for on-screen reading (the control group). The PDF documents contained identical text and images to the placemark balloons or "tour stops" in the Google Earth version. Some significant differences were noted between the two groups based on the immediate post-questionnaire with the KML students out-performing the PDF students, but not on the delayed measure. In a separate but related project, we undertake preliminary investigations into methods of teaching basic concepts in planetary mantle convection using numerical simulations. The goal of this project is to develop an interface with a two-dimensional finite element model that will allow students to vary parameters such as the temperatures assigned to the boundaries of the model domain, to help them actively explore important variables that control convection.

  18. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    2018 [PDF] October 2017 [PDF] July 2017 [PDF] April 2017 [PDF] January 2017 [PDF] October 2016 [PDF ] July 2016 [PDF] April 2016 [PDF] January 2016 [PDF] October 2015 [PDF] March 2015 [PDF] December 2014 [PDF] April 2014 [PDF] February 2014 [PDF] September 2013 [PDF] March 2013 [PDF] October, 2012 [PDF

  19. WEBTAS Software Life Cycle Development

    DTIC Science & Technology

    2006-09-01

    may be published in both html and pdf formats via menu selection. Adobe® FrameMaker ® 7.1 and Quadralay Corporation WebWorks® Professional 2003...X X WebTAS 2.5.3 ISAM X X WebTAS 2.5.3 Domain Editor Guide X X 13 The backbone of the ISS publishing environment consists of Adobe® FrameMaker ...and WebWorks® Publisher Professional 2003. FrameMaker ® provides an enterprise-class authoring and publishing solution that combines the

  20. Automotive Research Center

    Science.gov Websites

    | photos Web page Web page 2016 PDF | photos Web page Web page 2015 PDF | photos | video Web page Web page 2014 PDF | photos | videos Web page Web page 2013 PDF | photos Web page Web page 2012 PDF | photos Web page Web page 2011 PDF | photos PDF Web page 2010 PDF PDF PDF 2009 PDF PDF PDF 2008 PDF PDF PDF 2007

  1. ACHP | Case Digest - Protecting Historic Properties: Section 106 in Action

    Science.gov Websites

    Digest index. Previous issues: Summer 2012 (PDF) Spring 2012 (PDF) Winter 2012 (PDF) Fall 2011 (PDF ) Summer 2011 (PDF) Spring 2011 (PDF) Winter 2011 (PDF) Fall 2010 (PDF) Summer 2010 (PDF) Winter 2010 (PDF ) Fall 2009 (PDF) Summer 2009 (PDF) Spring 2009 (PDF) Winter 2009 (PDF) Fall 2008 (PDF) Summer 2008 (PDF

  2. The United States Army Operating Concept, 2016-2028

    DTIC Science & Technology

    2010-08-19

    NationalDefenseStrategy.pdf Biddle , T. D. (2010, April). Educating Senior Military Officers: Observations from the Carlisle Parapet. [Unpublished...node/4077 National Intelligence Council Global Trends 2025: A Transformed World. (2008, November). Retrieved from http://www.dni.gov/ nic ...author. 118 Dr. Tami Davis Biddle , “Educating Senior Military Officers: Observations from the Carlisle Parapet,” US Army War College, Carlisle

  3. Barrier Methods of Birth Control: Spermicide, Condom, Sponge, Diaphragm, and Cervical Cap

    MedlinePlus

    ... Education & Events Advocacy For Patients About ACOG Barrier Methods of Birth Control: Spermicide, Condom, Sponge, Diaphragm, and ... Cervical Cap FAQ022, March 2018 PDF Format Barrier Methods of Birth Control: Spermicide, Condom, Sponge, Diaphragm, and ...

  4. Alaska's State Forests

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  5. Simulation Modeling and Analysis of Device-Aware Network Architectures

    DTIC Science & Technology

    2004-12-01

    However, a potential issue lies in the location of the intermediate proxy with respect to the content servers; if the proxy is far away from the...to 11 guide the adaptation of content presented to that device [CC/PP, 2004]. The strength of CC/PP lies in its flexibility. CC/PP is based on RDF...from: http://ieeexplore.ieee.org/iel4/98/15881/00736473.pdf. Accessed October 2004. [Hu and Bagga, 2004] Jianying Hu and Amit Bagga, “Categorizing

  6. User’s Guide for SHIPINT - A Computer Program to Compute Two Ship Interaction in Waves

    DTIC Science & Technology

    1996-08-01

    P500693.PDF [Page: 1 of 84] Image Cover Sheet CLASSIFICATION SYSTEM NUMBER 500693 UNCLASSIFIED I llllll 111111111111111111111111111111111 TITLE...Halifax, Nova Scotia, Canada B3J 2X4 1 ---------· CONTRACTOR REPORT I I I I I iii;,"’: · 1 Defence Research Establishment Atlantic Canada...SUMMARY 1 Introduction 2 Coordinate Systems and Two Ship Motions 3 Flow Chart 4 Input Data File Description 4.1 shipint.in ........ . 4.2 paneLa.in

  7. Alaska Timber Jobs Task Force

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  8. Leukemia - B-Cell Prolymphocytic Leukemia and Hairy Cell Leukemia

    MedlinePlus

    ... a 1-page fact sheet that offers an introduction to CLL. This fact sheet is available as a PDF, so it is easy to print out. Cancer.Net Patient Education Video: View a short video led by an ASCO expert in leukemia ...

  9. Division of Forestry Fire and Aviation Program

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  10. Tanana Valley State Forest Citizens' Advisory Committee

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  11. Protecting America Through Better Civic Education

    DTIC Science & Technology

    2013-09-01

    27 Audiologist 3.99 Elementary—Pre-Kindergarten 2.74 Physical Therapist 3.91 Art/Visual Education 2.74 Languages—Spanish 3.88 Elementary...2009-recruitment-and-radicalization.pdf. 2 Wayne Drash, Boni Masu, and Tom Watkins, 2013, Boston Suspects: Immigrant Dream to American Nightmare, CNN...on our soil. Immigration issues within the U.S, especially at the southern border, must be considered. As we admit more immigrants into the country

  12. This is Your Life: A Career and Education Planning Guide: Educator's Companion

    ERIC Educational Resources Information Center

    Alberta Advanced Education and Technology, 2009

    2009-01-01

    This guide was developed to fill a need identified by high school educators and Alberta Advanced Education and Technology staff. The Guide introduces students to the principles of career and education planning and various authorized Alberta resources by helping students work through the planning process. The student guide is a series of modules…

  13. VizieR Online Data Catalog: FARGO_THORIN 1.0 hydrodynamic code (Chrenko+, 2017)

    NASA Astrophysics Data System (ADS)

    Chrenko, O.; Broz, M.; Lambrechts, M.

    2017-07-01

    This archive contains the source files, documentation and example simulation setups of the FARGO_THORIN 1.0 hydrodynamic code. The program was introduced, described and used for simulations in the paper. It is built on top of the FARGO code (Masset, 2000A&AS..141..165M, Baruteau & Masset, 2008ApJ...672.1054B) and it is also interfaced with the REBOUND integrator package (Rein & Liu, 2012A&A...537A.128R). THORIN stands for Two-fluid HydrOdynamics, the Rebound integrator Interface and Non-isothermal gas physics. The program is designed for self-consistent investigations of protoplanetary systems consisting of a gas disk, a disk of small solid particles (pebbles) and embedded protoplanets. Code features: I) Non-isothermal gas disk with implicit numerical solution of the energy equation. The implemented energy source terms are: Compressional heating, viscous heating, stellar irradiation, vertical escape of radiation, radiative diffusion in the midplane and radiative feedback to accretion heating of protoplanets. II) Planets evolved in 3D, with close encounters allowed. The orbits are integrated using the IAS15 integrator (Rein & Spiegel, 2015MNRAS.446.1424R). The code detects the collisions among planets and resolve them as mergers. III) Refined treatment of the planet-disk gravitational interaction. The code uses a vertical averaging of the gravitational potential, as outlined in Muller & Kley (2012A&A...539A..18M). IV) Pebble disk represented by an Eulerian, presureless and inviscid fluid. The pebble dynamics is affected by the Epstein gas drag and optionally by the diffusive effects. We also implemented the drag back-reaction term into the Navier-Stokes equation for the gas. Archive summary: ------------------------------------------------------------------------- directory/file Explanation ------------------------------------------------------------------------- /in_relax Contains setup of the first example simulation /in_wplanet Contains setup of the second example simulation /srcmain Contains the source files of FARGOTHORIN /src_reb Contains the source files of the REBOUND integrator package to be linked with THORIN GUNGPL3 GNU General Public License, version 3 LICENSE License agreement README Simple user's guide UserGuide.pdf Extended user's guide refman.pdf Programer's guide ----------------------------------------------------------------------------- (1 data file).

  14. Employment Opportunities

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  15. Forest Stewardship Committee

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  16. Robust plan optimization for electromagnetic transponder guided hypo-fractionated prostate treatment using volumetric modulated arc therapy

    NASA Astrophysics Data System (ADS)

    Zhang, Pengpeng; Hunt, Margie; Happersett, Laura; Yang, Jie; Zelefsky, Michael; Mageras, Gig

    2013-11-01

    To develop an optimization algorithm for volumetric modulated arc therapy which incorporates an electromagnetic tracking (EMT) guided gating strategy and is robust to residual intra-fractional motion uncertainties. In a computer simulation, intra-fractional motion traces from prior treatments with EMT were converted to a probability distribution function (PDF), truncated using a patient specific action volume that encloses allowed deviations from the planned position, and renormalized to yield a new PDF with EMT-gated interventions. In lieu of a conventional planning target volume (PTV), multiple instances of clinical target volume (CTV) and organs at risk (OARs) were replicated and displaced to extreme positions inside the action volume representing possible delivery scenarios. When optimizing the volumetric modulated arc therapy plan, doses to the CTV and OARs were calculated as a sum of doses to the replicas weighted by the PDF to account for motion. A treatment plan meeting the clinical constraints was produced and compared to the counterpart conventional margin (PTV) plan. EMT traces from a separate testing database served to simulate motion during gated delivery. Dosimetric end points extracted from dose accumulations for each motion trace were utilized to evaluate potential clinical benefit. Five prostate cases from a hypofractionated protocol (42.5 Gy in 5 fractions) were retrospectively investigated. The patient specific gating window resulted in tight anterior and inferior action levels (∼1 mm) to protect rectal wall and bladder wall, and resulted in an average of four beam interruptions per fraction in the simulation. The robust-optimized plans achieved the same average CTV D95 coverage of 40.5 Gy as the PTV-optimized plans, but with reduced patient-averaged rectum wall D1cc by 2.2 Gy (range 0.7 to 4.7 Gy) and bladder wall mean dose by 2.9 Gy (range 2.0 to 3.4 Gy). Integration of an intra-fractional motion management strategy into the robust optimization process is feasible and may yield improved OAR sparing compared to the standard margin approach.

  17. Robust plan optimization for electromagnetic transponder guided hypo-fractionated prostate treatment using volumetric modulated arc therapy.

    PubMed

    Zhang, Pengpeng; Hunt, Margie; Happersett, Laura; Yang, Jie; Zelefsky, Michael; Mageras, Gig

    2013-11-07

    To develop an optimization algorithm for volumetric modulated arc therapy which incorporates an electromagnetic tracking (EMT) guided gating strategy and is robust to residual intra-fractional motion uncertainties. In a computer simulation, intra-fractional motion traces from prior treatments with EMT were converted to a probability distribution function (PDF), truncated using a patient specific action volume that encloses allowed deviations from the planned position, and renormalized to yield a new PDF with EMT-gated interventions. In lieu of a conventional planning target volume (PTV), multiple instances of clinical target volume (CTV) and organs at risk (OARs) were replicated and displaced to extreme positions inside the action volume representing possible delivery scenarios. When optimizing the volumetric modulated arc therapy plan, doses to the CTV and OARs were calculated as a sum of doses to the replicas weighted by the PDF to account for motion. A treatment plan meeting the clinical constraints was produced and compared to the counterpart conventional margin (PTV) plan. EMT traces from a separate testing database served to simulate motion during gated delivery. Dosimetric end points extracted from dose accumulations for each motion trace were utilized to evaluate potential clinical benefit. Five prostate cases from a hypofractionated protocol (42.5 Gy in 5 fractions) were retrospectively investigated. The patient specific gating window resulted in tight anterior and inferior action levels (~1 mm) to protect rectal wall and bladder wall, and resulted in an average of four beam interruptions per fraction in the simulation. The robust-optimized plans achieved the same average CTV D95 coverage of 40.5 Gy as the PTV-optimized plans, but with reduced patient-averaged rectum wall D1cc by 2.2 Gy (range 0.7 to 4.7 Gy) and bladder wall mean dose by 2.9 Gy (range 2.0 to 3.4 Gy). Integration of an intra-fractional motion management strategy into the robust optimization process is feasible and may yield improved OAR sparing compared to the standard margin approach.

  18. canvasDesigner: A versatile interactive high-resolution scientific multi-panel visualization toolkit.

    PubMed

    Zhang, Baohong; Zhao, Shanrong; Neuhaus, Isaac

    2018-05-03

    We present a bioinformatics and systems biology visualization toolkit harmonizing real time interactive exploring and analyzing of big data, full-fledged customizing of look-n-feel, and producing multi-panel publication-ready figures in PDF format simultaneously. Source code and detailed user guides are available at http://canvasxpress.org, https://baohongz.github.io/canvasDesigner, and https://baohongz.github.io/canvasDesigner/demo_video.html. isaac.neuhaus@bms.com, baohong.zhang@pfizer.com, shanrong.zhao@pfizer.com. Supplementary materials are available at https://goo.gl/1uQygs.

  19. Second Line of Defense: Electronic Maintenance Reports, Local Maintenance Provider User Guide, Rev. 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leigh, Richard J.

    2012-09-01

    The Electronic Maintenance Report forms allow Local Maintenance Providers (LMP) and other program staff to enter maintenance information into a simple and secure system. This document describes the features and information required to complete the Maintenance Report forms. It is expected that all Corrective Maintenance Reports from LMPs will be submitted electronically into the SLD Portal. As an exception (e.g., when access to the SLD Portal is unavailable), Maintenance Reports can be submitted via a secure Adobe PDF form available through the Sustainability Manager assigned to each country.

  20. A Guide to Directors of Homeland Security, Emergency Management, and Military Departments in the States and Territories of the United States

    DTIC Science & Technology

    2007-12-01

    www3.state.id.us/idstat/ TOC /46010KTOC.html (Title 46—Militia and Military Affairs, chapter 10—State Disaster Preparedness Act). Adjutant General...officer in the national guard of Idaho and has attained the rank of colonel or above. Source: http://www3.state.id.us/idstat/ TOC /46001KTOC.html (Title 46...http://www.fortaleza.gobierno.pr/admin_fortaleza/ sistema /ordens/0028.pdf. Adjutant General Director: Colonel David Carrion Baralt Functions

  1. Review of Particle Physics

    NASA Astrophysics Data System (ADS)

    Patrignani, C.; Particle Data Group

    2016-10-01

    The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group (http://pdg.lbl.gov). The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. Contents Abstract, Contributors, Highlights and Table of ContentsAcrobat PDF (150 KB) IntroductionAcrobat PDF (456 KB) Particle Physics Summary Tables Gauge and Higgs bosonsAcrobat PDF (155 KB) LeptonsAcrobat PDF (134 KB) QuarksAcrobat PDF (84 KB) MesonsAcrobat PDF (871 KB) BaryonsAcrobat PDF (300 KB) Searches (Supersymmetry, Compositeness, etc.)Acrobat PDF (91 KB) Tests of conservation lawsAcrobat PDF (330 KB) Reviews, Tables, and Plots Detailed contents for this sectionAcrobat PDF (37 KB) Constants, Units, Atomic and Nuclear PropertiesAcrobat PDF (278 KB) Standard Model and Related TopicsAcrobat PDF (7.3 MB) Astrophysics and CosmologyAcrobat PDF (2.7 MB) Experimental Methods and CollidersAcrobat PDF (3.8 MB) Mathematical Tools or Statistics, Monte Carlo, Group Theory Acrobat PDF (1.3 MB) Kinematics, Cross-Section Formulae, and PlotsAcrobat PDF (3.9 MB) Particle Listings Illustrative key and abbreviationsAcrobat PDF (235 KB) Gauge and Higgs bosonsAcrobat PDF (2 MB) LeptonsAcrobat PDF (1.5 MB) QuarksAcrobat PDF (1.2 MB) Mesons: Light unflavored and strangeAcrobat PDF (4 MB) Mesons: Charmed and bottomAcrobat PDF (7.4 MB) Mesons: OtherAcrobat PDF (3.1 MB) BaryonsAcrobat PDF (3.97 MB) Miscellaneous searchesAcrobat PDF (2.4 MB) IndexAcrobat PDF (160 KB)

  2. Space-Based Astronomy: An Educator Guide with Activities for Science, Mathematics, and Technology Education.

    ERIC Educational Resources Information Center

    Vogt, Gregory L.

    This educator's guide features activities for science, mathematics, and technology education. The activities in this curriculum guide were developed based on the hands-on approach. The guide starts with introductory information and is followed by five units: (1) "The Atmospheric Filter"; (2) "The Electromagnetic Spectrum"; (3)…

  3. Special Education/Traffic Safety Education. Curriculum Guide.

    ERIC Educational Resources Information Center

    McBrayer, Clyde; Tidwell, Fred

    The curriculum guide for special education students is intended to serve as a supplement to the Washington 1980 State Traffice Safety Education Curriculum Guide. The guide is also correlated with two popular traffic safety texts. Each of the 21 modules contains a goal statement, a list of vocabulary words that might be difficult, a check sheet…

  4. An Analysis of Navy Managed Child Development Centers

    DTIC Science & Technology

    2015-06-01

    education system. The statistics gathered look at ethnicity/ sex /socio-economic background as well as results from various science, math, and language...Department. Retrieved from http://files.eric.ed.gov/fulltext/ED386297.pdf Laughlin, L. (2013). Who’s minding the kids ? Childcare arrangements: Spring 2011

  5. Alaska Community Forest Council

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  6. Firewood on Alaska State Lands

    Science.gov Websites

    Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure (PDF) Fire Management Plans Fire Assignments Annual Fire Statistics Fire Terms Glossary Incident Business Management Grants Become an Alaska Firewise Community Community Wildland Fire Protection Plans

  7. Blueprint for prescriber continuing education program.

    PubMed

    2012-06-01

    On October 25, 2011, the Center for Drug Evaluation and Research (CDER) of the Food and Drug Administration (FDA) posted online this Blueprint for Prescriber Continuing Education, labeled "final," relating to extended-release and long-acting opioids. The pending FDA Risk Evaluation Management Strategy (REMS) requires prescriber education. This document provides guidance to sponsors of these dosage forms in developing the prescvriber education component of their REMS. This report was posted online by the federal agency on October 25, 2011 at: http://www.fda.gov/downloads/drugs/drugsafety/informationbydrugclass/ucm277916.pdf. It is in the public domain.

  8. A Teacher's Guide to Resource - Use Outdoor Education Center.

    ERIC Educational Resources Information Center

    Taylor County Board of Public Instruction, Perry, FL.

    Included in this guide are ideas on evaluation and conduct of outdoor education classes and unit guides and lesson plans. An interdisciplinary approach is emphasized and the unit guides and lesson plans present activities related to science, mathematics, social studies, art, and music relevant to outdoor education in general. Unit guides for soil,…

  9. NASA Aeroelasticity Handbook Volume 2: Design Guides Part 2

    NASA Technical Reports Server (NTRS)

    Ramsey, John K. (Editor)

    2006-01-01

    The NASA Aeroelasticity Handbook comprises a database (in three formats) of NACA and NASA aeroelasticity flutter data through 1998 and a collection of aeroelasticity design guides. The Microsoft Access format provides the capability to search for specific data, retrieve it, and present it in a tabular or graphical form unique to the application. The full-text NACA and NASA documents from which the data originated are provided in portable document format (PDF), and these are hyperlinked to their respective data records. This provides full access to all available information from the data source. Two other electronic formats, one delimited by commas and the other by spaces, are provided for use with other software capable of reading text files. To the best of the author s knowledge, this database represents the most extensive collection of NACA and NASA flutter data in electronic form compiled to date by NASA. Volume 2 of the handbook contains a convenient collection of aeroelastic design guides covering fixed wings, turbomachinery, propellers and rotors, panels, and model scaling. This handbook provides an interactive database and design guides for use in the preliminary aeroelastic design of aerospace systems and can also be used in validating or calibrating flutter-prediction software.

  10. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Kindergarten.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This guide is first of a series of curriculum guides dealing with nutrition education in grades K-6. The curriculum guide was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting…

  11. 78 FR 16456 - Service Obligations for Connect America Phase II and Determining Who Is an Unsubsidized Competitor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... account potential activities relating to education, health, employment, e-commerce, and civic engagement... methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the instructions for submitting... native format (e.g., .doc, .xml, .ppt, searchable .pdf). Participants in this proceeding should...

  12. Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior.

    PubMed

    Seluzicki, Adam; Flourakis, Matthieu; Kula-Eversole, Elzbieta; Zhang, Luoying; Kilman, Valerie; Allada, Ravi

    2014-03-01

    Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+) and PDF(-) circadian pacemaker neurons and controlling pacemaker neuron output. Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA) in PDF(-) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor mutants. PKA subunit transcripts are also under clock control in non-PDF DN1p neurons. To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per⁰¹ mutants. PDF neuron rescue induced high amplitude rhythms in the clock component TIMELESS (TIM) in per-less DN1p neurons. Complete loss of PDF or PKA inhibition also results in reduced TIM levels in non-PDF neurons of per⁰¹ flies. To address how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarizes and increases firing rates of DN1p neurons. Surprisingly, these effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence of PKA inhibition. We have provided evidence for a signaling mechanism (PKA) and a molecular target (TIM) by which PDF resets and synchronizes clocks and demonstrates an acute direct excitatory effect of PDF on target neurons to control neuronal output. The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light, and neural network signaling. Moreover, these data reveal a bifurcation of PKA-dependent clock effects and PKA-independent output effects. Taken together, our results provide a molecular and cellular basis for the dual functions of PDF in clock resetting and pacemaker output.

  13. Dual PDF Signaling Pathways Reset Clocks Via TIMELESS and Acutely Excite Target Neurons to Control Circadian Behavior

    PubMed Central

    Seluzicki, Adam; Flourakis, Matthieu; Kula-Eversole, Elzbieta; Zhang, Luoying; Kilman, Valerie; Allada, Ravi

    2014-01-01

    Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+) and PDF(−) circadian pacemaker neurons and controlling pacemaker neuron output. Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA) in PDF(−) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor mutants. PKA subunit transcripts are also under clock control in non-PDF DN1p neurons. To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per01 mutants. PDF neuron rescue induced high amplitude rhythms in the clock component TIMELESS (TIM) in per-less DN1p neurons. Complete loss of PDF or PKA inhibition also results in reduced TIM levels in non-PDF neurons of per01 flies. To address how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarizes and increases firing rates of DN1p neurons. Surprisingly, these effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence of PKA inhibition. We have provided evidence for a signaling mechanism (PKA) and a molecular target (TIM) by which PDF resets and synchronizes clocks and demonstrates an acute direct excitatory effect of PDF on target neurons to control neuronal output. The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light, and neural network signaling. Moreover, these data reveal a bifurcation of PKA-dependent clock effects and PKA-independent output effects. Taken together, our results provide a molecular and cellular basis for the dual functions of PDF in clock resetting and pacemaker output. PMID:24643294

  14. 6th NCEP/NWS Ensemble User Workshop

    Science.gov Websites

    5th Ensemble Users Workshop pdf<> Discussion Hogsett/Bright pdf Session 2: NCEP Centers Review Chair: Jun Du Israel Jirak NCEP SPC's Review pdf David Bright NCEP AWC's Review pdf Wallace Hogsett NCEP WPC's Review pdf Joseph Sienkiewicz NCEP OPC's Review pdf Dave Unger NCEP CPC's Review pdf<>

  15. Defense.gov - Special Report: VOTE

    Science.gov Websites

    Voting Action Plan (pdf) 2013 USMC Voting Action Plan (pdf) 2013 Army Voting Action Plan (pdf) Air Force Voting Plan 2012-13 (pdf) Army Voting Action Plan 2012 (pdf) Marine Corps Voting Action Plan 2012 (pdf ) Navy Voting Action Plan (pdf) Overseas Vote Foundation Project Vote Smart Preparing for the 2012

  16. PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.

    PubMed

    Meelkop, Ellen; Temmerman, Liesbet; Janssen, Tom; Suetens, Nick; Beets, Isabel; Van Rompay, Liesbeth; Shanmugam, Nilesh; Husson, Steven J; Schoofs, Liliane

    2012-09-25

    In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying. We demonstrate that the pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant and that pdf-1 and pdf-2 behave antagonistically. All three PDF receptor splice variants are involved in the regulation of locomotor behavior. Cell specific rescue experiments show that this pdf mediated behavior is regulated by neurons rather than body wall muscles. We also show that egg-laying patterns of pdf-1 and pdf-2 mutants are affected, but not those of pdfr-1 mutants, pointing to a novel role for the PDF-system in the regulation of egg-laying. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. Individualized Education Program (IEP) Planning Guide for Special Education Students Entering High School Vocational Education Programs.

    ERIC Educational Resources Information Center

    Burrell, Lewis P.

    This guide is designed to assist school program planners who are working with mainstreamed special education students in vocational education programs. The guide, covering grades 11 and 12, contains vocational program goals, objectives, and evaluation measures for 30 secondary vocational education programs in 15 curriculum areas, as well as for…

  18. Sensitivity to Pigment-Dispersing Factor (PDF) Is Cell-Type Specific among PDF-Expressing Circadian Clock Neurons in the Madeira Cockroach.

    PubMed

    Gestrich, Julia; Giese, Maria; Shen, Wen; Zhang, Yi; Voss, Alexandra; Popov, Cyril; Stengl, Monika; Wei, HongYing

    2018-02-01

    Transplantation studies have pinpointed the circadian clock of the Madeira cockroach to the accessory medulla (AME) of the brain's optic lobes. The AME is innervated by approximately 240 adjacent neuropeptidergic neurons, including 12 pigment-dispersing factor (PDF)-expressing neurons anterior to the AME (aPDFMEs). Four of the aPDFMEs project contralaterally, controlling locomotor activity rhythms of the night-active cockroach. The present in vitro Ca 2+ imaging analysis focuses on contralaterally projecting AME neurons and their responses to PDF, GABA, and acetylcholine (ACh). First, rhodamine-dextran backfills from the contralateral optic stalk identified contralaterally projecting AME neurons, which were then dispersed in primary cell cultures. After characterization of PDF, GABA, and ACh responses, PDF immunocytochemistry identified ipsilaterally and contralaterally projecting PDFMEs. All PDF-sensitive clock neurons, PDF-immunoreactive clock neurons, and the majority of ipsilaterally and contralaterally projecting cells were excited by ACh. GABA inhibited all PDF-expressing clock neurons, and about half of other ipsilaterally projecting and most contralaterally projecting clock neurons. For the first time, we identified PDF autoreceptors in PDF-secreting cockroach circadian pacemakers. The medium-sized aPDFMEs and all other contralaterally projecting PDF-sensitive clock cells were inhibited by PDF. The ipsilaterally remaining small PDF-sensitive clock cells were activated by PDF. Only the largest aPDFME did not express PDF autoreceptors. We hypothesize that opposing PDF signaling generates 2 different ensembles of clock cells with antiphasic activity, regulating and maintaining a constant phase relationship between rest and activity cycles of the night-active cockroach.

  19. 32 CFR 108.2 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

  20. 32 CFR 108.2 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

  1. 32 CFR 108.2 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Internet at http://www.dtic.mil/whs/directives/corres/pdf/300005p.pdf. 2 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/220502p.pdf. 3 Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/231008p.pdf. ...

  2. Health Care and Education Reconciliation Act of 2010

    THOMAS, 111th Congress

    Rep. Spratt, John M., Jr. [D-SC-5

    2010-03-17

    03/30/2010 Became Public Law No: 111-152. (TXT | PDF) (All Actions) Notes: The bill makes a number of health-related financing and revenue changes to the Patient Protection and Affordable Care Act enacted by H.R.3590 and modifies higher education assistance provisions. Read together, H.R.3590 and the health care-related provisions of this bill are commonly... Tracker: This bill has the status Became LawHere are the steps for Status of Legislation:

  3. Grade Four, Environmental Education Guide.

    ERIC Educational Resources Information Center

    Project I-C-E, Green Bay, WI.

    This fourth grade environmental education guide is one of a series of guides, K-12, which were developed by teachers to help introduce environmental education into the total curriculum. The guides are supplementary in design; it is the teacher's decision when the concepts, objectives, activities, and resources may best be integrated into the…

  4. Grade One, Environmental Education Guide.

    ERIC Educational Resources Information Center

    Project I-C-E, Green Bay, WI.

    This first grade environmental education guide is one of a series of guides, K-12, which were developed by teachers to help introduce environmental education into the total curriculum. The guides are supplementary in design; it is the teacher's decision when the concepts, objectives, activities, and resources may best be integrated into the…

  5. Grade Three, Environmental Education Guide.

    ERIC Educational Resources Information Center

    Project I-C-E, Green Bay, WI.

    This third grade environmental education guide is one of a series of guides, K-12, that were developed by teachers to help introduce environmental education into the total curriculum. The guides are supplementary in design; it is the teacher's decision when the concepts, objectives, activities, and resources may best be integrated into the…

  6. 78 FR 76154 - Allocations, Waivers, and Alternative Requirements for Grantees Receiving Community Development...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ...://www.gpo.gov/fdsys/pkg/FR-2013-03-05/pdf/2013-05170.pdf http://www.gpo.gov/fdsys/pkg/FR-2013-04-19/pdf/2013-09228.pdf http://www.gpo.gov/fdsys/pkg/FR-2013-08-02/pdf/2013-18643.pdf . For grantees receiving...

  7. Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way.

    PubMed

    Wülbeck, Corinna; Grieshaber, Eva; Helfrich-Förster, Charlotte

    2009-10-01

    The neuropeptide pigment-dispersing factor (PDF) plays an essential role in the circadian clock of the fruit fly Drosophila melanogaster, but many details of PDF signaling in the clock network are still unknown. We tried to interfere with PDF signaling by blocking the GTPase Shibire in PDF neurons. Shibire is an ortholog of the mammalian Dynamins and is essential for endocytosis of clathrin-coated vesicles at the plasma membrane. Such endocytosis is used for neurotransmitter reuptake by presynaptic neurons, which is a prerequisite of synaptic vesicle recycling, and receptor-mediated endocytosis in the postsynaptic neuron, which leads to signal termination. By blocking Shibire function via overexpression of a dominant negative mutant form of Shibire in PDF neurons, we slowed down the behavioral rhythm by 3 h. This effect was absent in PDF receptor null mutants, indicating that we interfered with PDF receptor-mediated endocytosis. Because we obtained similar behavioral phenotypes by increasing the PDF level in regions close to PDF neurons, we conclude that blocking Shibire did prolong PDF signaling in the neurons that respond to PDF. Obviously, terminating the PDF signaling via receptor-mediated endocytosis is a crucial step in determining the period of behavioral rhythms.

  8. Resource Guide to Competency-Based Vocational Education: Distributive Education.

    ERIC Educational Resources Information Center

    Foster, Phillip R., Comp.

    This resource guide for classroom teachers contains annotations of resources representing recent instructional development in competency-based education for distributive education. It is also intended to assist curriculum specialists, administrators, and supervisors in development of performance-based instructional programs. The guide is divided…

  9. 32 CFR 117.55 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...))” (available at http://www.dtic.mil/whs/directives/corres/pdf/514301p.pdf) and DoD Instruction 5220.22, “National Industrial Security Program” (see http://www.dtic.mil/whs/directives/corres/pdf/522022p.pdf): (1...://www.dtic.mil/whs/directives/corres/pdf/522022p.pdf). (1) Make FOCI determinations on a case-by-case...

  10. 32 CFR 108.4 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Copies available on the Internet at http://www.dtic.mil/whs/directives/corres/pdf/100013p.pdf. (2) Non... Internet at http://www.dtic.mil/whs/directives/corres/pdf/605501p.pdf. (3) Any health care services...://www.dtic.mil/whs/directives/corres/pdf/302041p.pdf. (h) Emergency Health Care. The Secretaries of the...

  11. Signaling of Pigment-Dispersing Factor (PDF) in the Madeira Cockroach Rhyparobia maderae

    PubMed Central

    Funk, Nico W.; Giese, Maria; Baz, El-Sayed; Stengl, Monika

    2014-01-01

    The insect neuropeptide pigment-dispersing factor (PDF) is a functional ortholog of vasoactive intestinal polypeptide, the coupling factor of the mammalian circadian pacemaker. Despite of PDF's importance for synchronized circadian locomotor activity rhythms its signaling is not well understood. We studied PDF signaling in primary cell cultures of the accessory medulla, the circadian pacemaker of the Madeira cockroach. In Ca2+ imaging studies four types of PDF-responses were distinguished. In regularly bursting type 1 pacemakers PDF application resulted in dose-dependent long-lasting increases in Ca2+ baseline concentration and frequency of oscillating Ca2+ transients. Adenylyl cyclase antagonists prevented PDF-responses in type 1 cells, indicating that PDF signaled via elevation of intracellular cAMP levels. In contrast, in type 2 pacemakers PDF transiently raised intracellular Ca2+ levels even after blocking adenylyl cyclase activity. In patch clamp experiments the previously characterized types 1–4 could not be identified. Instead, PDF-responses were categorized according to ion channels affected. Application of PDF inhibited outward potassium or inward sodium currents, sometimes in the same neuron. In a comparison of Ca2+ imaging and patch clamp experiments we hypothesized that in type 1 cells PDF-dependent rises in cAMP concentrations block primarily outward K+ currents. Possibly, this PDF-dependent depolarization underlies PDF-dependent phase advances of pacemakers. Finally, we propose that PDF-dependent concomitant modulation of K+ and Na+ channels in coupled pacemakers causes ultradian membrane potential oscillations as prerequisite to efficient synchronization via resonance. PMID:25269074

  12. Aztec Ruins National Monument. Teacher's Guide, Grades 4-7.

    ERIC Educational Resources Information Center

    Nichols, Theresa, Comp.

    This teacher's guide is for educators in classrooms, outdoor education, youth groups, scouting, and after-school programs to teach about the Aztec Ruins National Monument (New Mexico). The teaching materials in the guide support the New Mexico educational standards in science, social studies, language arts, mathematics, and art. Since the guide's…

  13. A Revised Guide for Improving Teacher Education in Human Rights.

    ERIC Educational Resources Information Center

    Phi Delta Kappa, Bloomington, IN. Commission of Education, Human Rights, and Responsibilities.

    This document serves as a guide for teacher education institutions and programs designed to prepare educators for meeting their responsibilities in the area of human rights and human relations. This second edition of the guide represents a substantial modification of the original guide, and includes many activities, experiences, and suggestions…

  14. A Curriculum Guide for Energy Education - Vocational Home Economics Education. A Guide for Planning Performance-Based Energy Education in Home Economics Education Programs.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia. Home Economics Education Section.

    This guide serves as a resource for performance-based learning experiences designed to assist secondary school home economics students in developing competencies essential for effective energy use and management. A rationale for performance-based vocational education; definitions/explanations of the terms…

  15. Mobile technologies in medical education: AMEE Guide No. 105.

    PubMed

    Masters, Ken; Ellaway, Rachel H; Topps, David; Archibald, Douglas; Hogue, Rebecca J

    2016-06-01

    Mobile technologies (including handheld and wearable devices) have the potential to enhance learning activities from basic medical undergraduate education through residency and beyond. In order to use these technologies successfully, medical educators need to be aware of the underpinning socio-theoretical concepts that influence their usage, the pre-clinical and clinical educational environment in which the educational activities occur, and the practical possibilities and limitations of their usage. This Guide builds upon the previous AMEE Guide to e-Learning in medical education by providing medical teachers with conceptual frameworks and practical examples of using mobile technologies in medical education. The goal is to help medical teachers to use these concepts and technologies at all levels of medical education to improve the education of medical and healthcare personnel, and ultimately contribute to improved patient healthcare. This Guide begins by reviewing some of the technological changes that have occurred in recent years, and then examines the theoretical basis (both social and educational) for understanding mobile technology usage. From there, the Guide progresses through a hierarchy of institutional, teacher and learner needs, identifying issues, problems and solutions for the effective use of mobile technology in medical education. This Guide ends with a brief look to the future.

  16. An Integrated Nonlinear Analysis library - (INA) for solar system plasma turbulence

    NASA Astrophysics Data System (ADS)

    Munteanu, Costel; Kovacs, Peter; Echim, Marius; Koppan, Andras

    2014-05-01

    We present an integrated software library dedicated to the analysis of time series recorded in space and adapted to investigate turbulence, intermittency and multifractals. The library is written in MATLAB and provides a graphical user interface (GUI) customized for the analysis of space physics data available online like: Coordinated Data Analysis Web (CDAWeb), Automated Multi Dataset Analysis system (AMDA), Planetary Science Archive (PSA), World Data Center Kyoto (WDC), Ulysses Final Archive (UFA) and Cluster Active Archive (CAA). Three main modules are already implemented in INA : the Power Spectral Density (PSD) Analysis, the Wavelet and Intemittency Analysis and the Probability Density Functions (PDF) analysis.The layered structure of the software allows the user to easily switch between different modules/methods while retaining the same time interval for the analysis. The wavelet analysis module includes algorithms to compute and analyse the PSD, the Scalogram, the Local Intermittency Measure (LIM) or the Flatness parameter. The PDF analysis module includes algorithms for computing the PDFs for a range of scales and parameters fully customizable by the user; it also computes the Flatness parameter and enables fast comparison with standard PDF profiles like, for instance, the Gaussian PDF. The library has been already tested on Cluster and Venus Express data and we will show relevant examples. Research supported by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 313038/STORM, and a grant of the Romanian Ministry of National Education, CNCS UEFISCDI, project number PN-II-ID PCE-2012-4-0418.

  17. The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.

    PubMed

    Lear, Bridget C; Zhang, Luoying; Allada, Ravi

    2009-07-01

    Discrete clusters of circadian clock neurons temporally organize daily behaviors such as sleep and wake. In Drosophila, a network of just 150 neurons drives two peaks of timed activity in the morning and evening. A subset of these neurons expresses the neuropeptide pigment dispersing factor (PDF), which is important for promoting morning behavior as well as maintaining robust free-running rhythmicity in constant conditions. Yet, how PDF acts on downstream circuits to mediate rhythmic behavior is unknown. Using circuit-directed rescue of PDF receptor mutants, we show that PDF targeting of just approximately 30 non-PDF evening circadian neurons is sufficient to drive morning behavior. This function is not accompanied by large changes in core molecular oscillators in light-dark, indicating that PDF RECEPTOR likely regulates the output of these cells under these conditions. We find that PDF also acts on this focused set of non-PDF neurons to regulate both evening activity phase and period length, consistent with modest resetting effects on core oscillators. PDF likely acts on more distributed pacemaker neuron targets, including the PDF neurons themselves, to regulate rhythmic strength. Here we reveal defining features of the circuit-diagram for PDF peptide function in circadian behavior, revealing the direct neuronal targets of PDF as well as its behavioral functions at those sites. These studies define a key direct output circuit sufficient for multiple PDF dependent behaviors.

  18. Demographic Trends, Policy Influences, and Economic Effects in China and India Through 2025

    DTIC Science & Technology

    2011-04-01

    see Bardhan (2003). 42 over four children per woman. These northern states are poor and have weak infrastructure, educational systems, and...www.hsph.harvard.edu/pgda/WorkingPapers/2010/PGDA_WP_53.pdf Bardhan , Pranab, “Crouching Tiger, Lumbering Elephant: A China-India Comparison,” in Kaushik

  19. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1997-07-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Joining capacitors R Bridges King Edward's School, Birmingham B15 2UA, UK Enjoying Physics John Bausor 5 Longcrofte Road, Edgware, Middlesex HA8 6RR, UK The disadvantages of success M L Cooper Newham College of Further Education, London

  20. Smart Grid Educational Series | Energy Systems Integration Facility | NREL

    Science.gov Websites

    generation through transmission, all the way to the distribution infrastructure. Download presentation | Text on key takeaways from breakout group discussions. Learn more about the workshop. Text Version Text presentation PDF | Text Version Using MultiSpeak Data Model Standard & Essence Anomaly Detection for ICS

  1. Healthy Water Healthy People Water Quality Educators Guide

    ERIC Educational Resources Information Center

    Project WET Foundation, 2003

    2003-01-01

    This 200-page activity guide for educators of students in grades six through university level raises the awareness and understanding of water quality issues and their relationship to personal, public and environmental health. "Healthy Water Healthy People Water Quality Educators Guide" will help educators address science standards through 25…

  2. Outline Guide to Educational Reform Initiatives. ERS Research Digest.

    ERIC Educational Resources Information Center

    Educational Research Service, Arlington, VA.

    Many educational reform initiatives are being tried in an effort to restructure the American school system. This guide compares major educational reform efforts by goal, vision, teaching and learning, and system components. The first section of the guide covers major systemic educational reform initiatives, including Accelerated Schools Project,…

  3. Recipe for a Small Workshop: A Population Education Leader's Guide.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    A variety of resources, learning activities, and instructional materials make up this population education resource kit. Four major components comprise the kit. The first section is a leader's guide for the organization of an educational workshop about population education. Designed for teachers and community people, the workshop guide presents…

  4. Generation of TNFalpha and interleukin-6 by peritoneal macrophages after overnight dwells with bicarbonate- or lactate-buffered dialysis fluid.

    PubMed

    Liberek, Tomasz; Lichodziejewska-Niemierko, Monika; Knopinska-Posluszny, Wanda; Schaub, Thomas P; Kirchgessner, Judith; Passlick-Deetjen, Jutta; Rutkowski, Boleslaw

    2002-01-01

    In order to evaluate the biocompatibility profile of a newly designed peritoneal dialysis fluid (PDF), we evaluated peritoneal leukocyte (PMphi) cytokine release following overnight in vivo dwells using standard, lactate-buffered, single-chamber bag PDF (Lac-PDF) and purely bicarbonate-buffered, double-chamber bag PDF containing 34 (Bic-PDF) or 39 (Bic Hi-PDF) mmol/L bicarbonate. A randomized, open, crossover clinical trial with single weekly test dwells was performed in stable, long-term continuous ambulatory PD patients (n = 8). During 8-hour overnight dwells, PMphi were exposed to different PDF containing 1.5% glucose. After drainage, peritoneal cells were isolated and incubated with RPMI 1640 medium for 2 or 3 hours, with and without stimulation by lipopolysaccharide (LPS). Ex vivo release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 was measured by specific ELISA technique. After pre-exposure to Lac-PDF, PMphi generated 242 +/- 279 pg TNFalpha/10(6) cells and 157 +/- 105 pg IL-6/10(6) cells. When pre-exposed to Bic-PDF and Bic Hi-PDF, TNFa and IL-6 production of PMphi was not significantly different from Lac-PDF. After LPS stimulation (100 ng/mL), PMD secretion of TNFalpha and IL-6 pre-exposed to three PDF revealed no significant differences between groups: TNFalpha was 2,864 +/- 1,216, 2,910 +/- 1,202, and 3,291 +/- 558 pg/10(6) cells after overnight dwells with Lac-PDF, Bic-PDF, and Bic Hi-PDF, respectively. Comparably, LPS-stimulated (100 pg/ mL) PMphi showed IL-6 secretion of 891 +/- 335, 1,380 +/- 1,149, and 1,442 +/- 966 pg/10(6) cells for Lac-PDF, Bic-PDF, and Bic Hi-PDF. After long-term overnight dwells, initial pH, the different buffers, and varying glucose degradation product levels of PDF do not strongly affect PMphi function with respect to cytokine release. The lack of significant differences between fluids may result from the complete dialysate equilibration achieved during the overnight intraperitoneal dwell.

  5. Prevalence and associated variables of postdialysis fatigue: results of a prospective multicenter study.

    PubMed

    Bossola, Maurizio; Marzetti, Emanuele; Di Stasio, Enrico; Monteburini, Tania; Cenerelli, Stefano; Mazzoli, Katia; Parodi, Emanuele; Sirolli, Vittorio; Santarelli, Stefano; Ippoliti, Fabio; Nebiolo, Pier Eugenio; Bonomini, Mario; Melatti, Roberta; Vulpio, Carlo

    2017-04-17

    Little is known about postdialysis fatigue (PDF), a debilitating symptom of hemodialysis patients. In 5 hemodialysis units of northern-centre Italy, patients were regarded to suffer from PDF if they spontaneously offered this complaint when asked the open-ended question: Do you feel better or worse after dialysis? If worse, please specify in which way. A complaint of fatigue would be probed further with questions directed at its duration, frequency and intensity, allowing creation of a fatigue index of severity (one third of the sum of these three parameters, each rated from 1 to 5). Patients were stratified into three groups according the severity of PDF: 1) score = 0; 2) score = 1-3; 3) score > 3. We studied 271 patients: 164 had PDF and 107 had not. PDF patients had significantly longer time of recovery after dialysis (TIRD). TIRD was significantly associated with PDF duration, intensity, and frequency. Patients with PDF were older and had a lower ADL score. At multivariate analysis, PDF was significantly associated with TIRD. In multivariate model that did not include TIRD, PDF was independently associated with age and ADL. Sixty patients had moderate PDF and 104 severe PDF. In patients with severe PDF, age and dialytic age were higher, ADL and IADL scores were lower, TIRD was longer and the ultrafiltration rate was lower. At multivariate analysis, PDF severity was independently associated with TIRD. In the model without TIRD, PDF severity was associated with ADL only. PDF is frequent and associated with age and ADL. Dialytic variables seem unrelated to PDF. This article is protected by copyright. All rights reserved.

  6. The Circadian Neuropeptide PDF Signals Preferentially through a Specific Adenylate Cyclase Isoform AC3 in M Pacemakers of Drosophila

    PubMed Central

    Duvall, Laura B.; Taghert, Paul H.

    2012-01-01

    The neuropeptide Pigment Dispersing Factor (PDF) is essential for normal circadian function in Drosophila. It synchronizes the phases of M pacemakers, while in E pacemakers it decelerates their cycling and supports their amplitude. The PDF receptor (PDF-R) is present in both M and subsets of E cells. Activation of PDF-R stimulates cAMP increases in vitro and in M cells in vivo. The present study asks: What is the identity of downstream signaling components that are associated with PDF receptor in specific circadian pacemaker neurons? Using live imaging of intact fly brains and transgenic RNAi, we show that adenylate cyclase AC3 underlies PDF signaling in M cells. Genetic disruptions of AC3 specifically disrupt PDF responses: they do not affect other Gs-coupled GPCR signaling in M cells, they can be rescued, and they do not represent developmental alterations. Knockdown of the Drosophila AKAP-like scaffolding protein Nervy also reduces PDF responses. Flies with AC3 alterations show behavioral syndromes consistent with known roles of M pacemakers as mediated by PDF. Surprisingly, disruption of AC3 does not alter PDF responses in E cells—the PDF-R(+) LNd. Within M pacemakers, PDF-R couples preferentially to a single AC, but PDF-R association with a different AC(s) is needed to explain PDF signaling in the E pacemakers. Thus critical pathways of circadian synchronization are mediated by highly specific second messenger components. These findings support a hypothesis that PDF signaling components within target cells are sequestered into “circadian signalosomes,” whose compositions differ between E and M pacemaker cell types. PMID:22679392

  7. The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila.

    PubMed

    Duvall, Laura B; Taghert, Paul H

    2012-01-01

    The neuropeptide Pigment Dispersing Factor (PDF) is essential for normal circadian function in Drosophila. It synchronizes the phases of M pacemakers, while in E pacemakers it decelerates their cycling and supports their amplitude. The PDF receptor (PDF-R) is present in both M and subsets of E cells. Activation of PDF-R stimulates cAMP increases in vitro and in M cells in vivo. The present study asks: What is the identity of downstream signaling components that are associated with PDF receptor in specific circadian pacemaker neurons? Using live imaging of intact fly brains and transgenic RNAi, we show that adenylate cyclase AC3 underlies PDF signaling in M cells. Genetic disruptions of AC3 specifically disrupt PDF responses: they do not affect other Gs-coupled GPCR signaling in M cells, they can be rescued, and they do not represent developmental alterations. Knockdown of the Drosophila AKAP-like scaffolding protein Nervy also reduces PDF responses. Flies with AC3 alterations show behavioral syndromes consistent with known roles of M pacemakers as mediated by PDF. Surprisingly, disruption of AC3 does not alter PDF responses in E cells--the PDF-R(+) LNd. Within M pacemakers, PDF-R couples preferentially to a single AC, but PDF-R association with a different AC(s) is needed to explain PDF signaling in the E pacemakers. Thus critical pathways of circadian synchronization are mediated by highly specific second messenger components. These findings support a hypothesis that PDF signaling components within target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M pacemaker cell types.

  8. A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.

    PubMed

    Lear, Bridget C; Merrill, C Elaine; Lin, Jui-Ming; Schroeder, Analyne; Zhang, Luoying; Allada, Ravi

    2005-10-20

    The neuropeptide Pigment-Dispersing Factor (PDF) plays a critical role in mediating circadian control of behavior in Drosophila. Here we identify mutants (groom-of-PDF; gop) that display phase-advanced evening activity and poor free-running rhythmicity, phenocopying pdf mutants. In gop mutants, a spontaneous retrotransposon disrupts a coding exon of a G protein-coupled receptor, CG13758. Disruption of the receptor is accompanied by phase-advanced oscillations of the core clock protein PERIOD. Moreover, effects on circadian timing induced by perturbation of PDF neurons require gop. Yet PDF oscillations themselves remain robust in gop mutants, suggesting that GOP acts downstream of PDF. gop is expressed most strongly in the dorsal brain in regions that lie in proximity to PDF-containing nerve terminals. Taken together, these studies implicate GOP as a PDF receptor in Drosophila.

  9. Fallon, Nevada FORGE Well 21-31 Wireline Logs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blankenship, Doug

    Included are the following wireline logs from the Fallon FORGE Well 21-31. Ormat_Forge 21-31_8.5 inch section: FMI data in PDF and DLIS formats; MSCT data in PDF format; Pressure and Temperature data in PDF, LAS, and DLIS formats; Sonic Scanner data in PDF, DLIS, and LAS formats (LAS format contains Stoneley Slowness, Shear Slowness, and Compressional Slowness logs); Triple Combo in PDF, DLIS, and LAS formats; and USIT data in DLIS and PDF formats. Ormat_Forge_21-31_12.25 inch section: Resistivity data in PDF and LAS formats; Sonic Scanner data in PDF, DLIS, and LAS formats (LAS format contains Stoneley Slowness, Shear Slowness,more » and Compressional Slowness logs); Triple Combo in PDF and LAS formats; and Caliper data in PDF format (DLIS format for caliper data is included in the Sonic Scanner DLIS).« less

  10. What Happens If They Say No? Preserving Access to Critical Commercial Space Capabilities during Future Crises

    DTIC Science & Technology

    2014-12-01

    SatelliteShortagesMayChokeOffMilitaryDroneExpansion.aspx; G. Ryan Faith and Mariel John , “Space Report 2011” in Authoritative Guide to Global Space Activity,” ed. Micah Walter-Range (Colorado Springs...Werner, “Cover Story”; John Walcott, “Chinese Espionage Campaign Targets U.S. Space Technology,” Bloomberg, 18 April 2012, http://www.bloomberg.com...frus1969-76v25.pdf; Walter J. Boyne , The Two O’Clock War: The 1973 Yom Kippur Conflict and the Airlift That Saved Israel, 1st ed. (New York: Thomas

  11. FAA Offers Free Guide on Elementary Aviation Education.

    ERIC Educational Resources Information Center

    Journal of Aerospace Education, 1978

    1978-01-01

    Describes a teaching guide in aviation education for grades 2 through 6. The guide contains activities designed to enrich an existing science curriculum. An address for ordering the guide is included. (MA)

  12. Individualized Study Guide on Apiculture: Instructor's Guide. Curriculum Materials for Agricultural Education.

    ERIC Educational Resources Information Center

    Housmam, John L.; And Others

    The instructor's guide is coordinated for use with the student guide. The guide includes suggestions for teacher preparation, equipment and supply needs, suggested references, available audiovisual materials, open-ended questions for classroom discussion, educational opportunities for students, and a form for student evaluation of the study guide.…

  13. Signaling of pigment-dispersing factor (PDF) in the Madeira cockroach Rhyparobia maderae.

    PubMed

    Wei, Hongying; Yasar, Hanzey; Funk, Nico W; Giese, Maria; Baz, El-Sayed; Stengl, Monika

    2014-01-01

    The insect neuropeptide pigment-dispersing factor (PDF) is a functional ortholog of vasoactive intestinal polypeptide, the coupling factor of the mammalian circadian pacemaker. Despite of PDF's importance for synchronized circadian locomotor activity rhythms its signaling is not well understood. We studied PDF signaling in primary cell cultures of the accessory medulla, the circadian pacemaker of the Madeira cockroach. In Ca²⁺ imaging studies four types of PDF-responses were distinguished. In regularly bursting type 1 pacemakers PDF application resulted in dose-dependent long-lasting increases in Ca²⁺ baseline concentration and frequency of oscillating Ca²⁺ transients. Adenylyl cyclase antagonists prevented PDF-responses in type 1 cells, indicating that PDF signaled via elevation of intracellular cAMP levels. In contrast, in type 2 pacemakers PDF transiently raised intracellular Ca²⁺ levels even after blocking adenylyl cyclase activity. In patch clamp experiments the previously characterized types 1-4 could not be identified. Instead, PDF-responses were categorized according to ion channels affected. Application of PDF inhibited outward potassium or inward sodium currents, sometimes in the same neuron. In a comparison of Ca²⁺ imaging and patch clamp experiments we hypothesized that in type 1 cells PDF-dependent rises in cAMP concentrations block primarily outward K⁺ currents. Possibly, this PDF-dependent depolarization underlies PDF-dependent phase advances of pacemakers. Finally, we propose that PDF-dependent concomitant modulation of K⁺ and Na⁺ channels in coupled pacemakers causes ultradian membrane potential oscillations as prerequisite to efficient synchronization via resonance.

  14. Industrial Arts Resource Supplement to the Consumer Education Curriculum Guide for Ohio.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

    The consumer education guide for industrial arts teachers was developed by a group of experienced teachers using the Consumer Education Curriculum Guide for Ohio, Grades K-12 as a reference. The guide is organized in six sections, each dealing with one of the following basic concepts: (1) the economic system, (2) income procurement, (3) consumer…

  15. Five Steps for Structuring Data-Informed Conversations and Action in Education. REL 2013-001

    ERIC Educational Resources Information Center

    Kekahio, Wendy; Baker, Myriam

    2013-01-01

    Using data strategically to guide decisions and actions can have a positive effect on education practices and processes. This facilitation guide shows education data teams how to move beyond simply reporting data to applying data to direct strategic action. Using guiding questions, suggested activities, and activity forms, this guide provides…

  16. A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF.

    PubMed

    Sheng, Ke; Cai, Jing; Brookeman, James; Molloy, Janelle; Christopher, John; Read, Paul

    2006-09-01

    Lung tumor motion trajectories measured by four-dimensional CT or dynamic MRI can be converted to a probability density function (PDF), which describes the probability of the tumor at a certain position, for PDF based treatment planning. Using this method in simulated sequential tomotherapy, we study the dose reduction of normal tissues and more important, the effect of PDF reproducibility on the accuracy of dosimetry. For these purposes, realistic PDFs were obtained from two dynamic MRI scans of a healthy volunteer within a 2 week interval. The first PDF was accumulated from a 300 s scan and the second PDF was calculated from variable scan times from 5 s (one breathing cycle) to 300 s. Optimized beam fluences based on the second PDF were delivered to the hypothetical gross target volume (GTV) of a lung phantom that moved following the first PDF The reproducibility between two PDFs varied from low (78%) to high (94.8%) when the second scan time increased from 5 s to 300 s. When a highly reproducible PDF was used in optimization, the dose coverage of GTV was maintained; phantom lung receiving 10%-20% prescription dose was reduced by 40%-50% and the mean phantom lung dose was reduced by 9.6%. However, optimization based on PDF with low reproducibility resulted in a 50% underdosed GTV. The dosimetric error increased nearly exponentially as the PDF error increased. Therefore, although the dose of the tumor surrounding tissue can be theoretically reduced by PDF based treatment planning, the reliability and applicability of this method highly depend on if a reproducible PDF exists and is measurable. By correlating the dosimetric error and PDF error together, a useful guideline for PDF data acquisition and patient qualification for PDF based planning can be derived.

  17. A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sheng, Ke; Cai Jing; Brookeman, James

    2006-09-15

    Lung tumor motion trajectories measured by four-dimensional CT or dynamic MRI can be converted to a probability density function (PDF), which describes the probability of the tumor at a certain position, for PDF based treatment planning. Using this method in simulated sequential tomotherapy, we study the dose reduction of normal tissues and more important, the effect of PDF reproducibility on the accuracy of dosimetry. For these purposes, realistic PDFs were obtained from two dynamic MRI scans of a healthy volunteer within a 2 week interval. The first PDF was accumulated from a 300 s scan and the second PDF wasmore » calculated from variable scan times from 5 s (one breathing cycle) to 300 s. Optimized beam fluences based on the second PDF were delivered to the hypothetical gross target volume (GTV) of a lung phantom that moved following the first PDF. The reproducibility between two PDFs varied from low (78%) to high (94.8%) when the second scan time increased from 5 s to 300 s. When a highly reproducible PDF was used in optimization, the dose coverage of GTV was maintained; phantom lung receiving 10%-20% prescription dose was reduced by 40%-50% and the mean phantom lung dose was reduced by 9.6%. However, optimization based on PDF with low reproducibility resulted in a 50% underdosed GTV. The dosimetric error increased nearly exponentially as the PDF error increased. Therefore, although the dose of the tumor surrounding tissue can be theoretically reduced by PDF based treatment planning, the reliability and applicability of this method highly depend on if a reproducible PDF exists and is measurable. By correlating the dosimetric error and PDF error together, a useful guideline for PDF data acquisition and patient qualification for PDF based planning can be derived.« less

  18. Education Office Application Design and Development

    NASA Technical Reports Server (NTRS)

    Johnson, Jamie E.

    2013-01-01

    The content of this project focuses on designing and implementing a new prototype website for the Kennedy Intern Tracking System (KITS). The goal of the new website is to allow the user to search for interns based on several different categories and fields. In hence, making it easier to find a count of interns matching a set of criteria. The KSC office of education is the primary users of KITS, their job is to recruit interns year-round. As a secondary goal, each user will be able to generate a report of their searches onto a portable document format (PDF) me. The results of each search will be set to a limited amount per page. This site will be used for Kennedy Space Center internal purposes only. After the implementations are done, a visual walk through using screen shots will be used to guide the users through all of the different scenarios that are likely to occur when the users are navigating through the site. In addition, a demo of the site will be presented to the KSC Office of Education. JavaScript and JQuery are the languages that will focus on the functionality of the implementation. Hyper Text Markup Language will be used to form the foundation for the body structure of the website. Ruby will be the programming language used to elevate the prototype to a dynamic website and enable the programmer to finish with in an efficient time frame. Cascading Style Sheet will be the language used for the design and styling purposes. Rails is the framework that the new website will be built upon. By default, the database will be managed by Sequel Lite (SQLite). All users will need to be granted special privileges in order to use the site.

  19. Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila.

    PubMed

    Talsma, Aaron D; Christov, Christo P; Terriente-Felix, Ana; Linneweber, Gerit A; Perea, Daniel; Wayland, Matthew; Shafer, Orie T; Miguel-Aliaga, Irene

    2012-07-24

    The role of the central neuropeptide pigment-dispersing factor (PDF) in circadian timekeeping in Drosophila is remarkably similar to that of vasoactive intestinal peptide (VIP) in mammals. Like VIP, PDF is expressed outside the circadian network by neurons innervating the gut, but the function and mode of action of this PDF have not been characterized. Here we investigate the visceral roles of PDF by adapting cellular and physiological methods to the study of visceral responses to PDF signaling in wild-type and mutant genetic backgrounds. We find that intestinal PDF acts at a distance on the renal system, where it regulates ureter contractions. We show that PdfR, PDF's established receptor, is expressed by the muscles of the excretory system, and present evidence that PdfR-induced cAMP increases underlie the myotropic effects of PDF. These findings extend the similarities between PDF and VIP beyond their shared central role as circadian regulators, and uncover an unexpected endocrine mode of myotropic action for an intestinal neuropeptide on the renal system.

  20. Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila

    PubMed Central

    Talsma, Aaron D.; Christov, Christo P.; Terriente-Felix, Ana; Linneweber, Gerit A.; Perea, Daniel; Wayland, Matthew; Shafer, Orie T.; Miguel-Aliaga, Irene

    2012-01-01

    The role of the central neuropeptide pigment-dispersing factor (PDF) in circadian timekeeping in Drosophila is remarkably similar to that of vasoactive intestinal peptide (VIP) in mammals. Like VIP, PDF is expressed outside the circadian network by neurons innervating the gut, but the function and mode of action of this PDF have not been characterized. Here we investigate the visceral roles of PDF by adapting cellular and physiological methods to the study of visceral responses to PDF signaling in wild-type and mutant genetic backgrounds. We find that intestinal PDF acts at a distance on the renal system, where it regulates ureter contractions. We show that PdfR, PDF's established receptor, is expressed by the muscles of the excretory system, and present evidence that PdfR-induced cAMP increases underlie the myotropic effects of PDF. These findings extend the similarities between PDF and VIP beyond their shared central role as circadian regulators, and uncover an unexpected endocrine mode of myotropic action for an intestinal neuropeptide on the renal system. PMID:22778427

  1. Vocational Safety Guide to Generalized Safety Provisions as They Apply to: Agricultural Education, Business and Office Education, Health Occupations Education, Home Economics Education, Industrial Arts Education, Marketing and Distributive Education, Trade and Technical Education.

    ERIC Educational Resources Information Center

    Dyrenfurth, Michael J.; Linhardt, Richard E.

    This vocational safety guide is designed to help Missouri school practitioners at all levels in providing for the safe instruction and work associated with practical arts and vocational and technical subjects. Covered in the individual sections of the guide are the following topics: Missouri legislation and regulations pertaining to school safety;…

  2. Aeronautics: An Educator's Guide with Activities in Science, Mathematics, and Technology Education.

    ERIC Educational Resources Information Center

    Anderson, Charles; Biggs, Pat; Brown, Deborah; Culivan, Steve; Ellis, Sue; Gerard, James; Hardwick, Ellen; Poff, Norm; Rosenberg, Carla; Shearer, Deborah; Tripp, Octavia; Ernst, Ron

    This educator's guide explains basic aeronautical concepts and provides a background in the history of aviation within the context of flight environment (atmosphere, airports, and navigation). The activities in this guide are designed to be uncomplicated and fun. They were developed by NASA Aerospace Education Services Program specialists who have…

  3. Entrepreneurship Education Instructor's Manual. Competency-Based Education.

    ERIC Educational Resources Information Center

    Miller, Sandra W.; Williams, Jamie C.

    This guide is intended for use in teaching a course in entrepreneurship that is geared toward high school seniors. Specifically, the materials included in the guide have been designed to be incorporated into business and office education and marketing education courses. The guide consists of a list of the tasks necessary for a person to be…

  4. Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons.

    PubMed

    Tomchik, Seth M; Davis, Ronald L

    2008-04-24

    In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression.

  5. Kentucky Consumer & Homemaking Education. Management-Consumer Education. Curriculum Guide, Semester Course.

    ERIC Educational Resources Information Center

    Waldrop, Suzanne H.

    Intended for use by teachers at the high school level, this curriculum guide, which is one in a series of guides for consumer and homemaking education in Kentucky, outlines a semester special interest course in home management. The two units, comprehensive I and II, which are prerequisites for this course are found in a separate guide (CE 017…

  6. Envisioning Arts Assessment: A Process Guide for Assessing Arts Education in School Districts and States.

    ERIC Educational Resources Information Center

    Pistone, Nancy

    This handbook is a guide to help educators and administrators with the decisions they face in the design of an arts assessment. The guide is divided into two broad parts: Part 1: "Background for Thoughtful Arts Education Assessment"; and Part 2: "Assessment Design in Action." The guide includes: (1) a brief background on the…

  7. Parenthood Education: A Curriculum Guide.

    ERIC Educational Resources Information Center

    Northern Illinois Univ., De Kalb. Dept. of Home Economics.

    This home economics education curriculum guide provides the teacher-developer with learner competencies for a parenthood education program. The guide is designed in the form of competency statements, criteria for the competency, and enabling activities. Chapter 1, parental relationships, contains competencies concerning preparation for parenthood,…

  8. Marketing Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Michigan State Univ., East Lansing. Coll. of Agriculture and Natural Resources Education Inst.

    This curriculum guide is intended to provide a common core of competencies from which to design an effective secondary marketing education program. Introductory materials include a definition of marketing education, objectives, outline of instructional content, and questions and answers regarding the curriculum guide. These practical materials are…

  9. Recent progress in the joint velocity-scalar PDF method

    NASA Technical Reports Server (NTRS)

    Anand, M. S.

    1995-01-01

    This viewgraph presentation discusses joint velocity-scalar PDF method; turbulent combustion modeling issues for gas turbine combustors; PDF calculations for a recirculating flow; stochastic dissipation model; joint PDF calculations for swirling flows; spray calculations; reduced kinetics/manifold methods; parallel processing; and joint PDF focus areas.

  10. K-12 Energy Education Program: A Conceptual Guide To K-12 Energy Education in Wisconsin.

    ERIC Educational Resources Information Center

    Wisconsin Univ., Stevens Point. Energy Center of Wisconsin.

    In addition to presenting concepts that can help students understand and make decisions about energy issues, this guide provides guidance for teachers to incorporate energy education into their curricula. The guide is divided into two major sections: (1) the Energy Education Conceptual Framework and (2) the Suggested Scope and Sequence. The…

  11. Evaluating Environmental Education in Schools. A Practical Guide for Teachers. Environmental Education Series 12.

    ERIC Educational Resources Information Center

    Bennett, Dean B.

    A general approach to environmental education evaluation and practical knowledge about the area of educational evaluation are offered in this teacher's guide. An introductory section explains both the use of the guide and use of a four step evaluation process. Practical aspects of evaluation are highlighted in six chapters through specific…

  12. Guided Educational Tourism as Informal Physical Geography Education on St. Helena Island, Michigan

    ERIC Educational Resources Information Center

    Lane, Joseph M.; Stoltman, Joseph P.

    2017-01-01

    Guided educational tours are a major activity within informal education. This article examines the potential for tour guides of a largely historical tour of St. Helena Island, Michigan, to include physical geography within the tour. Using field data and interview methods, the researchers identified the physical features of the island that could be…

  13. Kentucky Consumer & Homemaking Education. Management-Consumer Education. Curriculum Guide, Comprehensive Courses.

    ERIC Educational Resources Information Center

    Waldrop, Suzanne H.

    Intended for use by teachers on the junior high and high school levels, this curriculum guide, which is one in a series of guides for consumer and homemaking education in Kentucky, outlines three courses in the area of management-consumer education. The junior high unit acquaints the student with the concepts of decision making and assessing…

  14. A Guide to Outdoor Education Resources and Programs for the Handicapped. Outdoor Education for the Handicapped.

    ERIC Educational Resources Information Center

    Kentucky Univ., Lexington.

    The resource guide is designed to assist educators, park resource persons, and parents of disabled children in locating and identifying sources of information for developing, implementing, and evaluating outdoor education programs for all disabled children and youth. The guide has two main parts. The first part contains an annotated bibliography…

  15. Disaster Preparation and Recovery - Multiple Languages

    MedlinePlus

    ... Telephone Alerts - العربية (Arabic) PDF Healthy Roads Media Tornadoes - English PDF Tornadoes - العربية (Arabic) PDF Healthy Roads Media Volunteers Needed - ... Telephone Alerts - bosanski (Bosnian) MP4 Healthy Roads Media Tornadoes - English PDF Tornadoes - bosanski (Bosnian) PDF Tornadoes - English ...

  16. Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila.

    PubMed

    Isaac, R Elwyn; Johnson, Erik C; Audsley, Neil; Shirras, Alan D

    2007-12-01

    Recent studies have firmly established pigment dispersing factor (PDF), a C-terminally amidated octodecapeptide, as a key neurotransmitter regulating rhythmic circadian locomotory behaviours in adult Drosophila melanogaster. The mechanisms by which PDF functions as a circadian peptide transmitter are not fully understood, however; in particular, nothing is known about the role of extracellular peptidases in terminating PDF signalling at synapses. In this study we show that PDF is susceptible to hydrolysis by neprilysin, an endopeptidase that is enriched in synaptic membranes of mammals and insects. Neprilysin cleaves PDF at the internal Ser7-Leu8 peptide bond to generate PDF1-7 and PDF8-18. Neither of these fragments were able to increase intracellular cAMP levels in HEK293 cells cotransfected with the Drosophila PDF receptor cDNA and a firefly luciferase reporter gene, confirming that such cleavage results in PDF inactivation. The Ser7-Leu8 peptide bond was also the principal cleavage site when PDF was incubated with membranes prepared from heads of adult Drosophila. This endopeptidase activity was inhibited by the neprilysin inhibitors phosphoramidon (IC(50,) 0.15 micromol l(-1)) and thiorphan (IC(50,) 1.2 micromol l(-1)). We propose that cleavage by a member of the Drosophila neprilysin family of endopeptidases is the most likely mechanism for inactivating synaptic PDF and that neprilysin might have an important role in regulating PDF signals within circadian neural circuits.

  17. Persistent Deterioration of Functioning (PDF) and change in well-being in older persons.

    PubMed

    Jonker, Angèle A; Comijs, Hannie C; Knipscheer, Kees C; Deeg, Dorly J

    2008-10-01

    It is often assumed that aging is accompanied by diverse and constant functional and cognitive decline, and it is therefore surprising that the well-being of older persons does not appear to decline in the same way. This study investigates longitudinally whether well-being in older persons changes due to Persistent Deterioration of Functioning (PDF). Data were collected in the context of the Longitudinal Aging Study Amsterdam (LASA). Conditions of PDF are persistent decline in cognitive functioning, physical functioning and increase in chronic diseases. Measurements of well-being included life satisfaction, positive affect, and valuation of life. T-tests were used to analyse mean difference scores for well-being, and univariate and multivariate regression analyses were performed to examine changes in three well-being outcomes in relation to PDF. Cross-sectional analyses showed significant differences and associations between the two PDF subgroups and non- PDF for well-being at T3. In longitudinal analyses, we found significant decreases in and associations with wellbeing over time in respondents fulfilling one PDF condition (mild PDF). For respondents fulfilling two or more PDF conditions (severe PDF), longitudinally no significant associations were found. Cognitive aspects of well-being (life satisfaction and valuation of life) and the affective element (positive affect) of well-being appear to be influenced negatively by mild PDF, whereas well-being does not seem to be diminished in persons with more severe PDF. This may be due to the ability to accept finally the inevitable situation of severe PDF.

  18. Kinetic and dynamic probability-density-function descriptions of disperse turbulent two-phase flows

    NASA Astrophysics Data System (ADS)

    Minier, Jean-Pierre; Profeta, Christophe

    2015-11-01

    This article analyzes the status of two classical one-particle probability density function (PDF) descriptions of the dynamics of discrete particles dispersed in turbulent flows. The first PDF formulation considers only the process made up by particle position and velocity Zp=(xp,Up) and is represented by its PDF p (t ;yp,Vp) which is the solution of a kinetic PDF equation obtained through a flux closure based on the Furutsu-Novikov theorem. The second PDF formulation includes fluid variables into the particle state vector, for example, the fluid velocity seen by particles Zp=(xp,Up,Us) , and, consequently, handles an extended PDF p (t ;yp,Vp,Vs) which is the solution of a dynamic PDF equation. For high-Reynolds-number fluid flows, a typical formulation of the latter category relies on a Langevin model for the trajectories of the fluid seen or, conversely, on a Fokker-Planck equation for the extended PDF. In the present work, a new derivation of the kinetic PDF equation is worked out and new physical expressions of the dispersion tensors entering the kinetic PDF equation are obtained by starting from the extended PDF and integrating over the fluid seen. This demonstrates that, under the same assumption of a Gaussian colored noise and irrespective of the specific stochastic model chosen for the fluid seen, the kinetic PDF description is the marginal of a dynamic PDF one. However, a detailed analysis reveals that kinetic PDF models of particle dynamics in turbulent flows described by statistical correlations constitute incomplete stand-alone PDF descriptions and, moreover, that present kinetic-PDF equations are mathematically ill posed. This is shown to be the consequence of the non-Markovian characteristic of the stochastic process retained to describe the system and the use of an external colored noise. Furthermore, developments bring out that well-posed PDF descriptions are essentially due to a proper choice of the variables selected to describe physical systems and guidelines are formulated to emphasize the key role played by the notion of slow and fast variables.

  19. 76 FR 5363 - Intent To Compromise Claim Against the State of Oklahoma Department of Education

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... must have Adobe Acrobat Reader, which is available free at this site. Note: The official version of this document is the document published in the Federal Register. Free Internet access to the official... Document Format (PDF) on the Internet at the following site: http://frwebgate.access.gpo.gov/cgi-bin...

  20. 75 FR 3212 - Office of Elementary and Secondary Education; College Assistance Migrant Program (CAMP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... Federal Register. Free Internet access to the official edition of the Federal Register and the Code of... (FRS), toll free, at 1-800-877-8339. Accessible Format: Individuals with disabilities can obtain this... published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  1. 75 FR 3216 - Office of Elementary and Secondary Education; High School Equivalency Program (HEP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... Federal Register. Free Internet access to the official edition of the Federal Register and the Code of... (FRS), toll free, at 1-800-877-8339. Accessible Format: Individuals with disabilities can obtain this... published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  2. Analysing Culture and Interculture in Saudi EFL Textbooks: A Corpus Linguistic Approach

    ERIC Educational Resources Information Center

    Almujaiwel, Sultan

    2018-01-01

    This paper combines corpus processing tools to investigate the cultural elements of Saudi education of English as a foreign language (EFL). The latest Saudi EFL textbooks (2016 onwards) are available in researchable PDF formats. This helps process them through corpus search software tools. The method adopted is based on analysing 20 cultural…

  3. Training Manual: NSDC's Standards for Staff Development [CD-ROM

    ERIC Educational Resources Information Center

    Roy, Patricia

    2006-01-01

    This 60-page guidebook presents a plan for a one-day workshop to introduce NSDC's standards to educators. The sessions are designed to encourage participant involvement to develop greater understanding of the standards. The slide presentation plus materials needed to conduct activities are included as PDF files on a CD-ROM. This guidebook may be…

  4. 77 FR 16542 - President's Advisory Commission on Educational Excellence for Hispanics

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ...: Tuesday, April 3, 2012. Time: 9 a.m.-5 p.m. Pacific Daylight Time. ADDRESSES: Loker Student Union Ballroom, California State University, Dominguez Hills, 1000 E. Victoria St., Carson, CA 90747, Tel: 310-243- 3303. FOR... use PDF, you must have Adobe Acrobat Reader, which is available free at this site. For questions about...

  5. 75 FR 38510 - Office of Special Education and Rehabilitative Services; Personnel Development to Improve...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and.... Electronic Access to This Document: You can view this document, as well as all other documents of this Department published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet...

  6. The Ocean Literacy Campaign

    NASA Astrophysics Data System (ADS)

    Schoedinger, S. E.; Strang, C.

    2008-12-01

    "Ocean Literacy is an understanding of the ocean's influence on you and your influence on the ocean." This simple statement captures the spirit of a conceptual framework supporting ocean literacy (COSEE et al., 2005). The framework comprises 7 essential principles and 44 fundamental concepts an ocean literate person would know (COSEE et al., 2005). The framework is the result of an extensive grassroots effort to reach consensus on (1) a definition for ocean literacy and (2) an articulation of the most important concepts to be understood by ocean-literate citizen (Cava et al., 2005). In the process of reaching consensus on these "big ideas" about the ocean, what began as a series of workshops has emerged as a campaign "owned" by an ever-expanding community of individuals, organizations and networks involved in developing and promoting the framework. The Ocean Literacy Framework has provided a common language for scientists and educators working together and serves as key guidance for the ocean science education efforts. This presentation will focus on the impact this Ocean Literacy Campaign has had to date as well as efforts underway to provide additional tools to enable educators and educational policy makers to further integrate teaching and learning about the ocean and our coasts into formal K-12 education and informal education. COSEE, National Geographic Society, NOAA, College of Exploration (2005). Ocean Literacy: The Essential Principles of Ocean Sciences Grades K-12, a jointly published brochure, URL: http://www.coexploration.org/oceanliteracy/documents/OceanLitChart.pdf Cava, F., S. Schoedinger , C. Strang, and P. Tuddenham (2005). Science Content and Standards for Ocean Literacy: A Report on Ocean Literacy, URL: http://www.coexploration.org/oceanliteracy/documents/OLit2004-05_Final_Report.pdf.

  7. Business Education Resource Guide. Bulletin No. 8322.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison. Bureau for Vocational Education.

    This guide lists a wide variety of business education resources of interest to business teachers (especially in Wisconsin). The guide is organized in 18 sections that cover the following topics: acronyms and definitions; audiovisual suppliers; bulletin boards and games; publishers for employability skills; educational institutions; facilities…

  8. Virginia Curriculum Management Guide.

    ERIC Educational Resources Information Center

    Virginia Commonwealth Univ., Richmond. School of Education.

    This document is a competency-based curriculum guide for use in marketing/distributive education programs in Virginia high schools. Following a section on the Virginia standards for competency-based education, the guide provides descriptions for all courses in the Virginia curriculum in the marketing/distributive education program. For each…

  9. Confirmatory factor analysis of teaching and learning guiding principles instrument among teacher educators in higher education institutions

    NASA Astrophysics Data System (ADS)

    Masuwai, Azwani; Tajudin, Nor'ain Mohd; Saad, Noor Shah

    2017-05-01

    The purpose of this study is to develop and establish the validity and reliability of an instrument to generate teaching and learning guiding principles using Teaching and Learning Guiding Principles Instrument (TLGPI). Participants consisted of 171 Malaysian teacher educators. It is an essential instrument to reflect in generating the teaching and learning guiding principles in higher education level in Malaysia. Confirmatory Factor Analysis has validated all 19 items of TLGPI whereby all items indicated high reliability and internal consistency. A Confirmatory Factor Analysis also confirmed that a single factor model was used to generate teaching and learning guiding principles.

  10. Articulation in Business Education for Secondary and Postsecondary Levels. Accounting Articulation Guide.

    ERIC Educational Resources Information Center

    Formby, Ronnie J.

    Focusing on courses in accounting, this guide is one of a set of four articulation guides designed for articulating between secondary and postsecondary business education courses. (The other three guides focus on courses in typewriting, shorthand, and office procedures.) Each guide presents a general course description, outlines of the major units…

  11. Conditional probability distribution function of "energy transfer rate" (PDF(ɛ|PVI)) as compared with its counterpart of temperature (PDF(T|PVI)) at the same condition of fluctuation

    NASA Astrophysics Data System (ADS)

    He, Jiansen; Wang, Yin; Pei, Zhongtian; Zhang, Lei; Tu, Chuanyi

    2017-04-01

    Energy transfer rate of turbulence is not uniform everywhere but suggested to follow a certain distribution, e.g., lognormal distribution (Kolmogorov 1962). The inhomogeneous transfer rate leads to emergence of intermittency, which may be identified with some parameter, e.g., normalized partial variance increments (PVI) (Greco et al., 2009). Large PVI of magnetic field fluctuations are found to have a temperature distribution with the median and mean values higher than that for small PVI level (Osman et al., 2012). However, there is a large proportion of overlap between temperature distributions associated with the smaller and larger PVIs. So it is recognized that only PVI cannot fully determine the temperature, since the one-to-one mapping relationship does not exist. One may be curious about the reason responsible for the considerable overlap of conditional temperature distribution for different levels of PVI. Usually the hotter plasma with higher temperature is speculated to be heated more with more dissipation of turbulence energy corresponding to more energy cascading rate, if the temperature fluctuation of the eigen wave mode is not taken into account. To explore the statistical relationship between turbulence cascading and plasma thermal state, we aim to study and reveal, for the first time, the conditional probability function of "energy transfer rate" under different levels of PVI condition (PDF(ɛ|PVI)), and compare it with the conditional probability function of temperature. The conditional probability distribution function, PDF(ɛ|PVI), is derived from PDF(PVI|ɛ)·PDF(ɛ)/PDF(PVI) according to the Bayesian theorem. PDF(PVI) can be obtained directly from the data. PDF(ɛ) is derived from the conjugate-gradient inversion of PDF(PVI) by assuming reasonably that PDF(δB|σ) is a Gaussian distribution, where PVI=|δB|/ σ and σ ( ɛι)1/3. PDF(ɛ) can also be acquired from fitting PDF(δB) with an integral function ∫PDF(δB|σ)PDF(σ)d σ. As a result, PDF(ɛ|PVI) is found to shift to higher median value of ɛ with increasing PVI but with a significant overlap of PDFs for different PVIs. Therefore, PDF(ɛ|PVI) is similar to PDF(T|PVI) in the sense of slow migration along with increasing PVI. The detailed comparison between these two conditional PDFs are also performed.

  12. China in Mexico: More Opportunity than Risk

    DTIC Science & Technology

    2011-10-17

    FDI Quality, and Plant Mortality,” World Development 37, 6 (2011): 1069- 1082 , http://ea.panam.edu/cbes/pdf/WorkingPaper1- 06.pdf. 26 Ayala, “The...1069- 1082 , http://ea.panam.edu/cbes/pdf/WorkingPaper1- 06.pdf. 9 What the study did identify were policies pursuing “proximity dependent...Mortality.” World Development 37, 6, (2011): 1069- 1082 . http://ea.panam.edu/cbes/pdf/WorkingPaper1-06.pdf. 19 Sauvant, Karl P., and Ken Davies

  13. Pigment-dispersing factor (PDF) has different effects on Drosophila's circadian clocks in the accessory medulla and in the dorsal brain.

    PubMed

    Wülbeck, Corinna; Grieshaber, Eva; Helfrich-Förster, Charlotte

    2008-10-01

    The neuropeptide pigment-dispersing factor (PDF) is a key transmitter in the circadian clock of Drosophila melanogaster. Here we studied the rhythmic behavior of neural mutants with modified arborizations of the large PDF neurons. In sine oculis(1) (so(1)) mutants we found a higher density of PDF fibers in the fly's pacemaker center, the accessory medulla. These flies exhibited a significantly longer period (24.6 h) than control flies. When PDF levels were elevated to very high levels in the dorsal brain as true for so(mda) mutants and small optic lobes;so(1) double mutants (sol(1);so( 1)), a short-period component split off the long period in behavioral rhythmicity. The short period became shorter the higher the amount of PDF in this brain region and reached a value of approximately 21 h. The period alterations were clearly dependent on PDF, because so(1);Pdf 01 and so(mda);Pdf 01 double mutants showed a single free-running component with a period similar to Pdf 01 mutants (approximately 22.5 h) and significantly longer than the short period of so(mda) mutants. These observations indicate that PDF feeds back on the clock neurons and changes their period. Obviously, PDF lengthens the period of some clock neurons and shortens that of others.

  14. Health Information in Hindi (हिन्दी)

    MedlinePlus

    ... हिन्दी (Hindi) Bilingual PDF Health Information Translations Power Outages - English PDF Power Outages - हिन्दी (Hindi) Bilingual PDF Health Information ... हिन्दी (Hindi) Bilingual PDF Health Information Translations Nuclear Scans Bone Scan - English PDF Bone Scan - हि ...

  15. The in vitro toxicity of peritoneal dialysis fluid.

    PubMed

    Manuprasert, Wasin; Kanchanabuch, Sirigul; Eiam-Ong, Somchai; Kanjanabuch, Talerngsak

    2011-09-01

    To investigate the toxicity of peritoneal dialysis fluid (PDF) components on peritoneal changes in primary human mesothelial cell. To investigate the mechanism of changes, primary human peritoneal mesothelial cells (HPMCs) were isolated from human omental tissue and were exposed for 15 hours with the various concentrations of conventional PDF and various PDF components. The mesothelial injury was determined by calculating a ratio of supernatant and total intracellular LDH while mesothelial apoptosis was assessed and counted by positive TUNEL staining and flow cytometry, respectively. PDF caused mesothelial detachment, de-differentiation, cell injuries, and apoptosis and this depended on the concentrations of PDF. The acidic condition and high glucose concentration likely played a major role in the HPMC injuries and detachment while individual PDF component could not yield mesothelial apoptosis as severe as the whole PDF effects. Thus, the additive effects of PDF composition, instead of the effect of each component, contributed to dialysis-related HPMC damages. PDF showed concentration dependent fashion-induced HPMC injury, dedifferentiation, and apoptosis. All of the abnormalities occurred by the additive effects of PDF components.

  16. Graphic Communications. Career Education Guide.

    ERIC Educational Resources Information Center

    Dependents Schools (DOD), Washington, DC. European Area.

    The curriculum guide is designed to provide students with realistic training in graphic communications theory and practice within the secondary educational framework and to prepare them for entry into an occupation or continuing postsecondary education. The program modules outlined in the guide have been grouped into four areas: printing,…

  17. Studying Educational Effectiveness in Rural Settings: A Guide for Researchers

    ERIC Educational Resources Information Center

    Sheridan, Susan; Dynarski, Mark; Bovaird, James

    2017-01-01

    This guide provides experienced education researchers with suggestions for conducting high-quality effectiveness studies to overcome research challenges common to rural settings. The guide addresses four factors that researchers must consider when conducting educational effectiveness research in rural settings: (1) study design, (2) recruitment of…

  18. A Facilitator's Guide for the Online Course: What Education Leaders Should Know about Virtual Education

    ERIC Educational Resources Information Center

    Rukobo, Emily Zyko; Penfold, Angela; Adler, C. Ralph; Larson, Heidi; Peterson, Kirsten

    2012-01-01

    This Facilitator's Guide is based on What Education Leaders Should Know about Virtual Education, an online course designed by the Center on Instruction and the New England Comprehensive Center. The Facilitator's Guide demonstrates step-by-step how to build the course on a learning management system (LMS) and provides instructions on all phases of…

  19. JSA guideline for the management of malignant hyperthermia crisis 2016.

    PubMed

    2017-04-01

    Malignant hyperthermia (MH) can be fatal if the crisis is not appropriately treated. It is an inherited disease usually triggered by the administration of volatile inhalational anesthetics and/or succinylcholine, a muscle relaxant. In a patient with suspected MH, the mechanism of calcium release from storage in the sarcoplasmic reticulum in the skeletal muscle is abnormally accelerated. Unexplained hypercarbia representing >55 mmHg of end-tidal carbon dioxide, tachycardia, and muscle rigidity (including masseter muscle rigidity) are early signs of the initiation of MH, because the metabolism is accelerated. The body temperature can rise by >0.5 °C/15 min and may reach ≥40 °C. Respiratory and metabolic acidosis, arrhythmia, cola-colored urine, increased levels of serum potassium, and tented T-waves on electrocardiogram are common and can lead to cardiac arrest. MH should be treated by discontinuation of the triggering agents, administration of intravenous dantrolene (initially 1 mg/kg), and reduction of the body temperature. Early diagnosis and sufficient dantrolene with body temperature reduction are essential to relieve the patient's MH crisis. This guideline in Japanese translation has been posted on the website: http://www.anesth.or.jp/guide/pdf/guideline_akuseikounetsu.pdf .

  20. SU-F-T-94: Plan2pdf - a Software Tool for Automatic Plan Report for Philips Pinnacle TPS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, C

    Purpose: To implement an automatic electronic PDF plan reporting tool for Philips Pinnacle treatment planning system (TPS) Methods: An electronic treatment plan reporting software is developed by us to enable fully automatic PDF report from Pinnacle TPS to external EMR programs such as MOSAIQ. The tool is named “plan2pdf”. plan2pdf is implemented using Pinnacle scripts, Java and UNIX shell scripts, without any external program needed. plan2pdf supports full auto-mode and manual mode reporting. In full auto-mode, with a single mouse click, plan2pdf will generate a detailed Pinnacle plan report in PDF format, which includes customizable cover page, Pinnacle plan summary,more » orthogonal views through each plan POI and maximum dose point, DRR for each beam, serial transverse views captured throughout the dose grid at a user specified interval, DVH and scorecard windows. The final PDF report is also automatically bookmarked for each section above for convenient plan review. The final PDF report can either be saved on a user specified folder on Pinnacle, or it can be automatically exported to an EMR import folder via a user configured FTP service. In manual capture mode, plan2pdf allows users to capture any Pinnacle plan by full screen, individual window or rectangular ROI drawn on screen. Furthermore, to avoid possible patients’ plan mix-up during auto-mode reporting, a user conflict check feature is included in plan2pdf: it prompts user to wait if another patient is being exported by plan2pdf by another user. Results: plan2pdf is tested extensively and successfully at our institution consists of 5 centers, 15 dosimetrists and 10 physicists, running Pinnacle version 9.10 on Enterprise servers. Conclusion: plan2pdf provides a highly efficient, user friendly and clinical proven platform for all Philips Pinnacle users, to generate a detailed plan report in PDF format for external EMR systems.« less

  1. Scalar Dissipation Modeling for Passive and Active Scalars: a priori Study Using Direct Numerical Simulation

    NASA Technical Reports Server (NTRS)

    Selle, L. C.; Bellan, Josette

    2006-01-01

    Transitional databases from Direct Numerical Simulation (DNS) of three-dimensional mixing layers for single-phase flows and two-phase flows with evaporation are analyzed and used to examine the typical hypothesis that the scalar dissipation Probability Distribution Function (PDF) may be modeled as a Gaussian. The databases encompass a single-component fuel and four multicomponent fuels, two initial Reynolds numbers (Re), two mass loadings for two-phase flows and two free-stream gas temperatures. Using the DNS calculated moments of the scalar-dissipation PDF, it is shown, consistent with existing experimental information on single-phase flows, that the Gaussian is a modest approximation of the DNS-extracted PDF, particularly poor in the range of the high scalar-dissipation values, which are significant for turbulent reaction rate modeling in non-premixed flows using flamelet models. With the same DNS calculated moments of the scalar-dissipation PDF and making a change of variables, a model of this PDF is proposed in the form of the (beta)-PDF which is shown to approximate much better the DNS-extracted PDF, particularly in the regime of the high scalar-dissipation values. Several types of statistical measures are calculated over the ensemble of the fourteen databases. For each statistical measure, the proposed (beta)-PDF model is shown to be much superior to the Gaussian in approximating the DNS-extracted PDF. Additionally, the agreement between the DNS-extracted PDF and the (beta)-PDF even improves when the comparison is performed for higher initial Re layers, whereas the comparison with the Gaussian is independent of the initial Re values. For two-phase flows, the comparison between the DNS-extracted PDF and the (beta)-PDF also improves with increasing free-stream gas temperature and mass loading. The higher fidelity approximation of the DNS-extracted PDF by the (beta)-PDF with increasing Re, gas temperature and mass loading bodes well for turbulent reaction rate modeling.

  2. Military Review: The Professional Journal of the U.S. Army, Volume 90, Number 1, January-February 2000

    DTIC Science & Technology

    2000-02-01

    Bulletin 100-99-5/6 Now available in Adobe Acrobat ( pdf ) format CONTENTS Editorial PDF 2 Korean Conflict: A 50-Year Perspective 3 Task Force Smith...Revisited PDF by Lieutenant Colonel Joseph G.D. Babb, US Army, Retired 14 Harnessing Thunderbolts PDF by Major Kelly C. Jordan, US Army 20 North Korea...and the Bomb PDF by Stanley Weintraub 28 Busting Through PDF by Colonel John F. Antal, US Army 40 Planning for Major Theater Wars: Examining the

  3. Idaho Driver Education Instructional Guide. Revised.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise.

    This driver education instructional safety guide is organized in three sections: Driver Education; Motorcycle Education; and Driver Education for the Handicapped. The driver education section contains 10 units dealing with the following topics: parent orientation; student orientation; basic control skills; driver performance; driving regulations;…

  4. Home Economics Education Career Path Guide and Model Curriculum Standards.

    ERIC Educational Resources Information Center

    California State Univ., Northridge.

    This curriculum guide developed in California and organized in 10 chapters, provides a home economics education career path guide and model curriculum standards for high school home economics programs. The first chapter contains information on the following: home economics education in California, home economics careers for the future, home…

  5. Occupational Education for Students with Special Needs: Mechanical Assembly.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on mechanical assembly is one of a series of seventeen specialized curriculum guides for occupational education for the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach…

  6. Occupational Education for Students with Special Needs: Electronic Assembly.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on electronic assembly is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach…

  7. Occupational Education for Students with Special Needs: Graphics.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on graphics is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach job-required…

  8. Career Education Community Resource Guide.

    ERIC Educational Resources Information Center

    D'Lugin, Victor; And Others

    This guide, developed by the State Project to Implement Career Education (SPICE) in New York, is intended to serve as a model to assist teachers, guidance counselors, administrators, and project staff in using business and community resources in career education programs. The first section of the guide contains information on ways of updating and…

  9. Occupational Education for Students with Special Needs: Packaging.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on packaging is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach job-required…

  10. A Resource Guide for Information/Library Education in Developing Countries.

    ERIC Educational Resources Information Center

    Zahari, Noor Liza Ahmad

    This annotated guide to resources on library and information science education in developing countries includes materials on library schools, training and education of library staff, and the progress of libraries in specific countries. Materials in the guide were selected from the indexes of Library Literature, Library and Information Science…

  11. The Invasive Plant Species Education Guide

    ERIC Educational Resources Information Center

    Mason, Kevin; James, Krista; Carlson, Kitrina; D'Angelo, Jean

    2010-01-01

    To help high school students gain a solid understanding of invasive plant species, university faculty and students from the University of Wisconsin-Stout (UW-Stout) and a local high school teacher worked together to develop the Invasive Plant Species (IPS) Education Guide. The IPS Education Guide includes nine lessons that give students an…

  12. Community Development Guide. "A Guide for Restructuring Community Development in Agricultural Education."

    ERIC Educational Resources Information Center

    Wagley, Leon A.; And Others

    Information designed to acquaint teachers, teacher educators, and state supervisors of agricultural education with the concepts, roles, and procedures for developing a community development curriculum is presented in this guide. The first section is concerned with suggestions for restructuring materials relevant to teaching community development…

  13. Occupational Education for Students with Special Needs: Automotive Maintenance.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on automotive maintenance is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach…

  14. Educational Research in China: Guiding Principles and Major Tasks.

    ERIC Educational Resources Information Center

    Wu, Wei

    This account of efforts to reconstruct educational research in China, guided by Marxist principles and reflective of a national policy of building a "socialist spiritual civilization," presents the major requirements of that endeavor. Educational sciences are to be guided by four understandings: correct theories; realistic policies;…

  15. Health Education Curriculum Guide, Grades 1-12.

    ERIC Educational Resources Information Center

    Massachusetts State Dept. of Education, Boston. Bureau of Elementary and Secondary Education.

    This health education curriculum guide has been developed to assist local school districts develop stronger, more effective, school health programs. The guide is organized into four broad areas of health education: physical health, mental and social health, consumer and environmental health, and safe living. Each of these areas is divided into…

  16. MADE 1. Marketing and Distributive Education Competency Based Curriculum Guide.

    ERIC Educational Resources Information Center

    New Jersey State Dept. of Education, Trenton. Div. of Vocational Education.

    This curriculum guide is one in a series of three competency-based instructional materials dealing with marketing and distributive education (MADE). Covered in the individual sections of the guide are the following topics: job orientation (cooperative education work agreements, personal appearance, career opportunities, job applications, job…

  17. South Carolina Guide for Consumer Education I & II.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia. Office of Occupational Education.

    This guide is designed to provide job-relevant tasks, performance objectives, performance guides, resources, teaching activities, and instructional resources for teaching consumer education I and II in South Carolina. It may be used with any teaching method selected by the instructor. Consumer Education I contains four units: demonstrate…

  18. Occupational Education for Students with Special Needs: Floriculture.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on floriculture is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach job-required…

  19. Occupational Education for Students with Special Needs: Building Maintenance.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on building maintenance is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach…

  20. Articulation in Business Education for Secondary and Postsecondary Levels. Office Procedures Articulation Guide.

    ERIC Educational Resources Information Center

    Formby, Ronnie J.

    Focusing on courses in office procedures, this guide is one of a set of four articulation guides designed for articulating between secondary and postsecondary business education courses. (The other three guides focus on courses in typewriting, accounting, and shorthand.) Each guide presents a general course description, outlines of the major units…

  1. Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation.

    PubMed

    Klose, Markus; Duvall, Laura; Li, Weihua; Liang, Xitong; Ren, Chi; Steinbach, Joe Henry; Taghert, Paul H

    2016-05-18

    The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness and does not require endogenous ligand (PDF) signaling or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness reflects the properties of the pacemaker cell type, not the receptor. Dopamine responsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large LNv. The activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms. Additionally, cell-autonomous PDF signaling reversed the circadian behavioral effects of lowered RalA activity. Thus, RalA activity confers high PDF responsiveness, providing a daily gate around the dawn hours to promote functional PDF signaling. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging.

    PubMed

    Shafer, Orie T; Kim, Dong Jo; Dunbar-Yaffe, Richard; Nikolaev, Viacheslav O; Lohse, Martin J; Taghert, Paul H

    2008-04-24

    The neuropeptide PDF is released by sixteen clock neurons in Drosophila and helps maintain circadian activity rhythms by coordinating a network of approximately 150 neuronal clocks. Whether PDF acts directly on elements of this neural network remains unknown. We address this question by adapting Epac1-camps, a genetically encoded cAMP FRET sensor, for use in the living brain. We find that a subset of the PDF-expressing neurons respond to PDF with long-lasting cAMP increases and confirm that such responses require the PDF receptor. In contrast, an unrelated Drosophila neuropeptide, DH31, stimulates large cAMP increases in all PDF-expressing clock neurons. Thus, the network of approximately 150 clock neurons displays widespread, though not uniform, PDF receptivity. This work introduces a sensitive means of measuring cAMP changes in a living brain with subcellular resolution. Specifically, it experimentally confirms the longstanding hypothesis that PDF is a direct modulator of most neurons in the Drosophila clock network.

  3. Functional PDF Signaling in the Drosophila Circadian Neural Circuit is Gated by Ral A-Dependent Modulation

    PubMed Central

    Liang, Xitong; Ren, Chi; Steinbach, Joe Henry; Taghert, Paul H.

    2016-01-01

    The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness, does not require endogenous ligand (PDF) signaling, or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness reflects the properties of the pacemaker cell type, not the receptor. Dopamine responsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large LNv. The activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms. Additional, cell autonomous PDF signaling reversed the circadian behavioral effects of lowered RalA activity. Thus RalA activity confers high PDF responsiveness, providing a daily gate around the dawn hours to promote functional PDF signaling. PMID:27161526

  4. Overexpression of peptide deformylase in breast, colon, and lung cancers.

    PubMed

    Randhawa, Harsharan; Chikara, Shireen; Gehring, Drew; Yildirim, Tuba; Menon, Jyotsana; Reindl, Katie M

    2013-07-01

    Human mitochondrial peptide deformylase (PDF) has been proposed as a novel cancer therapeutic target. However, very little is known about its expression and regulation in human tissues. The purpose of this study was to characterize the expression pattern of PDF in cancerous tissues and to identify mechanisms that regulate its expression. The mRNA expression levels of PDF and methionine aminopeptidase 1D (MAP1D), an enzyme involved in a related pathway with PDF, were determined using tissue panels containing cDNA from patients with various types of cancer (breast, colon, kidney, liver, lung, ovarian, prostate, or thyroid) and human cell lines. Protein levels of PDF were also determined in 2 colon cancer patients via western blotting. Colon cancer cells were treated with inhibitors of ERK, Akt, and mTOR signaling pathways and the resulting effects on PDF and MAP1D mRNA levels were determined by qPCR for colon and lung cancer cell lines. Finally, the effects of a PDF inhibitor, actinonin, on the proliferation of breast, colon, and prostate cell lines were determined using the CyQUANT assay. PDF and MAP1D mRNA levels were elevated in cancer cell lines compared to non-cancer lines. PDF mRNA levels were significantly increased in breast, colon, and lung cancer samples while MAP1D mRNA levels were increased in just colon cancers. The expression of PDF and MAP1D varied with stage in these cancers. Further, PDF protein expression was elevated in colon cancer tissue samples. Inhibition of the MEK/ERK, but not PI3K or mTOR, pathway reduced the expression of PDF and MAP1D in both colon and lung cancer cell lines. Further, inhibition of PDF with actinonin resulted in greater reduction of breast, colon, and prostate cancer cell proliferation than non-cancer cell lines. This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers, and the first evidence that the MEK/ERK pathway plays a role in regulating the expression of PDF and MAP1D. The over-expression of PDF in several cancers and the inhibition of cancer cell growth by a PDF inhibitor suggest this enzyme may act as an oncogene to promote cancer cell proliferation.

  5. Overexpression of peptide deformylase in breast, colon, and lung cancers

    PubMed Central

    2013-01-01

    Background Human mitochondrial peptide deformylase (PDF) has been proposed as a novel cancer therapeutic target. However, very little is known about its expression and regulation in human tissues. The purpose of this study was to characterize the expression pattern of PDF in cancerous tissues and to identify mechanisms that regulate its expression. Methods The mRNA expression levels of PDF and methionine aminopeptidase 1D (MAP1D), an enzyme involved in a related pathway with PDF, were determined using tissue panels containing cDNA from patients with various types of cancer (breast, colon, kidney, liver, lung, ovarian, prostate, or thyroid) and human cell lines. Protein levels of PDF were also determined in 2 colon cancer patients via western blotting. Colon cancer cells were treated with inhibitors of ERK, Akt, and mTOR signaling pathways and the resulting effects on PDF and MAP1D mRNA levels were determined by qPCR for colon and lung cancer cell lines. Finally, the effects of a PDF inhibitor, actinonin, on the proliferation of breast, colon, and prostate cell lines were determined using the CyQUANT assay. Results PDF and MAP1D mRNA levels were elevated in cancer cell lines compared to non-cancer lines. PDF mRNA levels were significantly increased in breast, colon, and lung cancer samples while MAP1D mRNA levels were increased in just colon cancers. The expression of PDF and MAP1D varied with stage in these cancers. Further, PDF protein expression was elevated in colon cancer tissue samples. Inhibition of the MEK/ERK, but not PI3K or mTOR, pathway reduced the expression of PDF and MAP1D in both colon and lung cancer cell lines. Further, inhibition of PDF with actinonin resulted in greater reduction of breast, colon, and prostate cancer cell proliferation than non-cancer cell lines. Conclusions This is the first report showing that PDF is over-expressed in breast, colon, and lung cancers, and the first evidence that the MEK/ERK pathway plays a role in regulating the expression of PDF and MAP1D. The over-expression of PDF in several cancers and the inhibition of cancer cell growth by a PDF inhibitor suggest this enzyme may act as an oncogene to promote cancer cell proliferation. PMID:23815882

  6. Cooperative Marketing and Distributive Education I and II (Junior and Senior High School Students). Vocational Education Teacher-Coordinators Curriculum Guide. Bulletin 1702.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Div. of Vocational Education.

    Developed by experienced vocational teacher-coordinators and teacher-educators, this guide is intended to be used as a resource by cooperative distributive education and marketing teachers in Louisiana junior and senior high schools. The guide contains suggested curriculum for both beginning and advanced courses. Course I consists of 19 units in…

  7. Health Information in Somali (Af-Soomaali )

    MedlinePlus

    ... Af-Soomaali (Somali) Bilingual PDF Health Information Translations Pendulum Exercises for Shoulder - Af-Soomaali (Somali) Bilingual PDF ... Af-Soomaali (Somali) Bilingual PDF Health Information Translations Pendulum Exercises for Shoulder - Af-Soomaali (Somali) Bilingual PDF ...

  8. Alzheimer's Caregivers: MedlinePlus Health Topic

    MedlinePlus

    ... in Older Adults (National Institute on Aging) - PDF Wandering and Alzheimer's Disease (National Institute on Aging) - PDF ... in Older Adults (National Institute on Aging) - PDF Wandering and Alzheimer's Disease (National Institute on Aging) - PDF ...

  9. Comparative analysis of Pdf-mediated circadian behaviors between Drosophila melanogaster and D. virilis.

    PubMed

    Bahn, Jae Hoon; Lee, Gyunghee; Park, Jae H

    2009-03-01

    A group of small ventrolateral neurons (s-LN(v)'s) are the principal pacemaker for circadian locomotor rhythmicity of Drosophila melanogaster, and the pigment-dispersing factor (Pdf) neuropeptide plays an essential role as a clock messenger within these neurons. In our comparative studies on Pdf-associated circadian rhythms, we found that daily locomotor activity patterns of D. virilis were significantly different from those of D. melanogaster. Activities of D. virilis adults were mainly restricted to the photophase under light:dark cycles and subsequently became arrhythmic or weakly rhythmic in constant conditions. Such activity patterns resemble those of Pdf(01) mutant of D. melanogaster. Intriguingly, endogenous D. virilis Pdf (DvPdf) expression was not detected in the s-LN(v)-like neurons in the adult brains, implying that the Pdf(01)-like behavioral phenotypes of D. virilis are attributed in part to the lack of DvPdf in the s-LN(v)-like neurons. Heterologous transgenic analysis showed that cis-regulatory elements of the DvPdf transgene are capable of directing their expression in all endogenous Pdf neurons including s-LN(v)'s, as well as in non-Pdf clock neurons (LN(d)'s and fifth s-LN(v)) in a D. melanogaster host. Together these findings suggest a significant difference in the regulatory mechanisms of Pdf transcription between the two species and such a difference is causally associated with species-specific establishment of daily locomotor activity patterns.

  10. HSP induction in mesothelial cells by peritoneal dialysis fluid depends on biocompatibility test system.

    PubMed

    Bender, Thorsten O; Kratochwill, Klaus; Böhm, Michael; Jörres, Achim; Aufricht, Christoph

    2011-05-01

    We have previously shown that exposure of mesothelial cells (MC) to peritoneal dialysis fluids (PDF) not only caused toxic injury, but also induced cytoprotective heat shock proteins (HSP). This study was performed in order to compare HSP expression in MC upon PDF exposure in three currently used biocompatibility test systems. Omentum-derived human peritoneal MC underwent 3 modalities of exposure to heat- or filter-sterilized PDF: (A) pure PDF for 60 minutes followed by a recovery-period in pure culture medium for 24 hours; (B) 1:1 mixture of PDF and culture medium for 24 hours or (C) pure PDF for 60 minutes followed by a recovery-period in a 1:1 mixture of PDF and culture medium for 24 hours. Biocompatibility was assessed by LDH-release into the supernatant and HSP-72 expression in MC lysates. Short-term exposure of MC to pure PDF (Modality A) resulted in concordant LDH release and upregulation of HSP-72, regardless of heat or filter sterilization. In contrast, both test systems that exposed MC to heat-sterilized PDF during the recovery period (Modalities B and C) resulted in severe cellular lethality but low HSP-72 expression. This study clearly shows that HSP expression in MC upon PDF exposure depends on the biocompatibility test system. The presence of heat-sterilized PDF during recovery resulted in significant downregulation of Hsp-72 despite severe cell injury. Therefore, Hsp-72 expression reflects adequate cellular stress responses rather than PDF cytotoxicity.

  11. Space Science for Middle School Teachers: Integrating CINDI E/PO into a Long-Term Professional Development Program

    NASA Astrophysics Data System (ADS)

    Urquhart, M. L.; Hairston, M. R.

    2005-12-01

    Education and Public Outreach (E/PO) targeting pre-college education can be focused on teachers or students, but is ultimately only effective if it impacts classrooms. A challenge in the teacher workshop model is tracking the impact we have actually made. Teachers may be excited by our offerings, and rate workshops highly, but is our E/PO actually making a difference with pre-college students? In June 2005 we ran our second four-day teacher workshop for the joint NASA/U.S. Air Force sponsored ionospheric instrument package, the Coupled Ion Neutral Dynamics Investigation (CINDI) with a new twist. We experimented with the integration of our workshop into a long-term professional development program for 6th and 7th grade teachers at UT Dallas. Immediate direct benefits to the CINDI E/PO program included knowledge of teacher backgrounds prior to the workshop, a narrow target grade level range, and the elimination of the need for separate recruiting efforts. More importantly, by working within a year-long program supported by a Teacher Quality Grant we have been able to better assess teacher learning and the impact our outreach efforts is having on the middle school students of participants. The 20-contact hours our workshop contributed to the Teacher Quality Summer Institute were specifically designed to meet Texas standards for middle school science, and made connections between space weather, Earth systems, basic physics, technology, and communications. Participants were able to interact with members of the science team in formal settings and over casual lunches. We will present our motivations for this experiment, participant feedback, and lessons learned. In addition, we will give an update on our CINDI Educator Guide, and the newly completed Cindi in Space comic book. For the latest on CINDI E/PO, curriculum materials, and the comic book in pdf format, go to http://cindispace.utdallas.edu/education/.

  12. Comprehensive Guide for Middle School Programs. Instructor's Guide.

    ERIC Educational Resources Information Center

    Hansen, Joan

    This instructor's guide contains materials for use in teaching a middle school exploratory home economics course. Addressed in the individual units of the guide are the following topics: nutrition education and food management, parenting education, resource management, clothing management, and personal management. Each section contains a unit…

  13. Supernova Cosmology Project

    Science.gov Websites

    universe. PDF Top panel only of previous Hubble diagram Figure 6 PDF Figure 8 Confidence regions for Omega_Mass vs Omega_Lambda PDF Figure 8 with results from CMB and galaxy cluster data added. PDF Figure 12 Joint measurements of Omega_Mass and w assuming a flat universe and w constant in time. PDF These slides

  14. 78 FR 27431 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on April 19, 2013, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... project remains open, and 3D PDF intends to file additional written notifications disclosing all changes...

  15. 78 FR 72713 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on October 31, 2013, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... remains open, and 3D PDF intends to file additional written notifications disclosing all changes in...

  16. 32 CFR 105.1 - Purpose

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...,” December 16, 2011, can be found at http://www.sapr.mil/media/pdf/policy/DTM-11-063.pdf and DTM 11-062... Report on Care for Victims of Sexual Assault,” April 2004, can be found at http://www.sapr.mil/media/pdf.../media/pdf/policy/DTM-11-063.pdf; (14) DTM 11-062, “Document Retention in Cases of Restricted and...

  17. 32 CFR 105.1 - Purpose

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...,” December 16, 2011, can be found at http://www.sapr.mil/media/pdf/policy/DTM-11-063.pdf and DTM 11-062... Report on Care for Victims of Sexual Assault,” April 2004, can be found at http://www.sapr.mil/media/pdf.../media/pdf/policy/DTM-11-063.pdf; (14) DTM 11-062, “Document Retention in Cases of Restricted and...

  18. Daily rhythms in locomotor circuits in Drosophila involve PDF

    PubMed Central

    Pírez, Nicolás; Christmann, Bethany L.

    2013-01-01

    The neuropeptide pigment-dispersing factor (PDF) has been studied extensively in Drosophila, and its role in circadian time-keeping has been firmly established. The role of PDF outside of the clock circuit, however, is poorly understood. A recent study suggested that PDF may act on the ellipsoid body (EB) to link the clock and sleep/activity circuits. We performed whole brain optical imaging with the fluorescence resonance energy transfer (FRET)-based cAMP sensor Epac1-camps expressed under control of the pdfR promoter to address how the clock and sleep deprivation affect the physiology of these cells. Basal cAMP levels in EB were regulated both by PDF and synaptic inputs that are controlled by the circadian clock. Acute application of PDF to the brain caused a significant, and PDF-receptor-dependent, increase in cAMP in EB cells. Application of TTX to block circuit-mediated effects of PDF increased the morning response but not the response at night, implying the existence of a temporally regulated, PDF-stimulated input that blocks cAMP generation. ACh produced both direct (TTX-insensitive) and indirect (TTX-sensitive) increases in cAMP during the day but was totally TTX-insensitive at night, indicating that ACh-stimulated inputs to the EB are suppressed at night. Sleep deprivation did not affect the cAMP responses of these cells to either PDF or ACh. These results suggest a novel role for PDF as a modulator of activity outside of the clock circuit. By elucidating the mechanisms by which the neuropeptide PDF act on its target cells, our work contributes to our understating of how the central clock coordinates activity and sleep. PMID:23678016

  19. PDF and cAMP enhance PER stability in Drosophila clock neurons

    PubMed Central

    Li, Yue; Guo, Fang; Shen, James; Rosbash, Michael

    2014-01-01

    The neuropeptide PDF is important for Drosophila circadian rhythms: pdf01 (pdf-null) animals are mostly arrhythmic or short period in constant darkness and have an advanced activity peak in light–dark conditions. PDF contributes to the amplitude, synchrony, as well as the pace of circadian rhythms within clock neurons. PDF is known to increase cAMP levels in PDR receptor (PDFR)-containing neurons. However, there is no known connection of PDF or of cAMP with the Drosophila molecular clockworks. We discovered that the mutant period gene perS ameliorates the phenotypes of pdf-null flies. The period protein (PER) is a well-studied repressor of clock gene transcription, and the perS protein (PERS) has a markedly short half-life. The result therefore suggests that the PDF-mediated increase in cAMP might lengthen circadian period by directly enhancing PER stability. Indeed, increasing cAMP levels and cAMP-mediated protein kinase A (PKA) activity stabilizes PER, in S2 tissue culture cells and in fly circadian neurons. Adding PDF to fly brains in vitro has a similar effect. Consistent with these relationships, a light pulse causes more prominent PER degradation in pdf01 circadian neurons than in wild-type neurons. The results indicate that PDF contributes to clock neuron synchrony by increasing cAMP and PKA, which enhance PER stability and decrease clock speed in intrinsically fast-paced PDFR-containing clock neurons. We further suggest that the more rapid degradation of PERS bypasses PKA regulation and makes the pace of clock neurons more uniform, allowing them to avoid much of the asynchrony caused by the absence of PDF. PMID:24707054

  20. Daily rhythms in locomotor circuits in Drosophila involve PDF.

    PubMed

    Pírez, Nicolás; Christmann, Bethany L; Griffith, Leslie C

    2013-08-01

    The neuropeptide pigment-dispersing factor (PDF) has been studied extensively in Drosophila, and its role in circadian time-keeping has been firmly established. The role of PDF outside of the clock circuit, however, is poorly understood. A recent study suggested that PDF may act on the ellipsoid body (EB) to link the clock and sleep/activity circuits. We performed whole brain optical imaging with the fluorescence resonance energy transfer (FRET)-based cAMP sensor Epac1-camps expressed under control of the pdfR promoter to address how the clock and sleep deprivation affect the physiology of these cells. Basal cAMP levels in EB were regulated both by PDF and synaptic inputs that are controlled by the circadian clock. Acute application of PDF to the brain caused a significant, and PDF-receptor-dependent, increase in cAMP in EB cells. Application of TTX to block circuit-mediated effects of PDF increased the morning response but not the response at night, implying the existence of a temporally regulated, PDF-stimulated input that blocks cAMP generation. ACh produced both direct (TTX-insensitive) and indirect (TTX-sensitive) increases in cAMP during the day but was totally TTX-insensitive at night, indicating that ACh-stimulated inputs to the EB are suppressed at night. Sleep deprivation did not affect the cAMP responses of these cells to either PDF or ACh. These results suggest a novel role for PDF as a modulator of activity outside of the clock circuit. By elucidating the mechanisms by which the neuropeptide PDF act on its target cells, our work contributes to our understating of how the central clock coordinates activity and sleep.

  1. PDF and cAMP enhance PER stability in Drosophila clock neurons.

    PubMed

    Li, Yue; Guo, Fang; Shen, James; Rosbash, Michael

    2014-04-01

    The neuropeptide PDF is important for Drosophila circadian rhythms: pdf(01) (pdf-null) animals are mostly arrhythmic or short period in constant darkness and have an advanced activity peak in light-dark conditions. PDF contributes to the amplitude, synchrony, as well as the pace of circadian rhythms within clock neurons. PDF is known to increase cAMP levels in PDR receptor (PDFR)-containing neurons. However, there is no known connection of PDF or of cAMP with the Drosophila molecular clockworks. We discovered that the mutant period gene per(S) ameliorates the phenotypes of pdf-null flies. The period protein (PER) is a well-studied repressor of clock gene transcription, and the per(S) protein (PERS) has a markedly short half-life. The result therefore suggests that the PDF-mediated increase in cAMP might lengthen circadian period by directly enhancing PER stability. Indeed, increasing cAMP levels and cAMP-mediated protein kinase A (PKA) activity stabilizes PER, in S2 tissue culture cells and in fly circadian neurons. Adding PDF to fly brains in vitro has a similar effect. Consistent with these relationships, a light pulse causes more prominent PER degradation in pdf(01) circadian neurons than in wild-type neurons. The results indicate that PDF contributes to clock neuron synchrony by increasing cAMP and PKA, which enhance PER stability and decrease clock speed in intrinsically fast-paced PDFR-containing clock neurons. We further suggest that the more rapid degradation of PERS bypasses PKA regulation and makes the pace of clock neurons more uniform, allowing them to avoid much of the asynchrony caused by the absence of PDF.

  2. Shoulder Injuries and Disorders - Multiple Languages

    MedlinePlus

    ... Af-Soomaali (Somali) Bilingual PDF Health Information Translations Pendulum Exercises for Shoulder - Af-Soomaali (Somali) Bilingual PDF ... Exercises - español (Spanish) Bilingual PDF Health Information Translations Pendulum Exercises for Shoulder - English PDF Pendulum Exercises for ...

  3. Factsheets - Division of Mining, Land, and Water

    Science.gov Websites

    Recreational Mining Area PDF Commercial Recreation Day Use Registration PDF Commercial Recreation Facility Programs PDF Off-Road Travel On The North Slope On State Land PDF Permits for Commercial Recreation

  4. Using Perilog to Explore "Decision Making at NASA"

    NASA Technical Reports Server (NTRS)

    McGreevy, Michael W.

    2005-01-01

    Perilog, a context intensive text mining system, is used as a discovery tool to explore topics and concerns in "Decision Making at NASA," chapter 6 of the Columbia Accident Investigation Board (CAIB) Report, Volume I. Two examples illustrate how Perilog can be used to discover highly significant safety-related information in the text without prior knowledge of the contents of the document. A third example illustrates how "if-then" statements found by Perilog can be used in logical analysis of decision making. In addition, in order to serve as a guide for future work, the technical details of preparing a PDF document for input to Perilog are included in an appendix.

  5. Children with Severe Cerebral Palsy: An Educational Guide. Guides for Special Education No. 7.

    ERIC Educational Resources Information Center

    Rye, Henning, Ed.; Skjorten, Miriam Donath, Ed.

    The guide, intended to help teachers, parents, and community workers throughout the world develop educational services for children with severe cerebral palsy, is published in English, French, Spanish, Arabic, and Chinese. The 11 practitioner-contributed chapters stress specific intervention techniques based on the practitioners' own experiences…

  6. Distributive Education Resource Supplement to the Consumer Education Curriculum Guide for Ohio.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

    The activities contained in the guide are designed to supplement the distributive education curriculum with information that will prepare the student to become a more informed, skillful employee and help the marketing career oriented student better visualize his customer's buying problems. Four overall objectives are stated. The guide is organized…

  7. Advertising Services. A Suggested Curriculum Guide. Marketing and Distributive Education.

    ERIC Educational Resources Information Center

    Illinois State Univ., Normal. Dept. of Business Education.

    This publication is a curriculum guide designed to assist local educators in planning and implementing instructional programs for Office of Education Code 04.01, Advertising Services, a subcluster within the marketing and distribution cluster. The curricular guide is divided into two major sections. The first section contains information for the…

  8. Occupational Education for Students with Special Needs: Plastics Manufacturing and Assembling.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on plastics manufacturing and assembling is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed…

  9. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Grade 3.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This curriculum guide for nutrition education grade 3, was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting dental health through nutrition; models for diet selection;…

  10. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Grade 1.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This curriculum guide for nutrition education grade 1, was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting dental health through nutrition; models for diet selection;…

  11. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Grade 2.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This curriculum guide for nutrition education grade 2, was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting dental health through nutrition; models for diet selection;…

  12. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Grade 4.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This curriculum guide for nutrition education grade 4, was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting dental health through nutrition; models for diet selection;…

  13. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Grade 6.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This curriculum guide for nutrition education grade 6, was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting dental health through nutrition; models for diet selection;…

  14. Making Nutrition Education Count: A Guide for Nutrition Education K-6. Grade 5.

    ERIC Educational Resources Information Center

    Kratky, Patricia; Haigh, Lois

    This curriculum guide for nutrition education grade 5, was designed to incorporate knowledge of thirteen concepts into the child's decision-making processes as a food consumer. These concepts, as covered by the guide, are: affecting bodily well-being through nutrition; affecting dental health through nutrition; models for diet selection;…

  15. Early Years Education Resource Guide. Early Education Support Series.

    ERIC Educational Resources Information Center

    Dunlop, Aline-Wendy, Comp.

    The aim of this resource guide is to provide practitioners in preschool settings with information to help them plan, implement, augment with resources, and review practice based on the "Curriculum Framework for Children in Their Pre-School Year" issued by the Scottish Office Education and Industry Department. The guide presents a…

  16. Back to School: A Guide to Continuing Your Education after Prison

    ERIC Educational Resources Information Center

    Crayton, Anna; Lindahl, Nicole

    2015-01-01

    This guide is designed to help readers take the first steps towards continuing their education, whether that means learning English, working towards a High School Equivalency (HSE), learning an occupation, or building on college credits already earned. This guide walks readers through the process of setting educational goals and getting organized;…

  17. Methods of Teaching Vocational Education. 199-605. Two Credits. Student Study Guide.

    ERIC Educational Resources Information Center

    Wisconsin Univ.-Stout, Menomonie. Dept. of Industrial and Marketing Education.

    This self-paced study guide is designed to meet certification requirements for new Wisconsin teachers in the Wisconsin Vocational, Technical, and Adult Education system. The format is individualized and competency based. The guide must be used with the Performance-Based Teacher Education Modules published by the American Association for Vocational…

  18. Applying Outcome Measurements: A Guide to Educational Outcome Measurements and Their Uses. Seminar No. 5.

    ERIC Educational Resources Information Center

    Glaser, Ezra

    This guide is essentially designed as a teaching aid for those who would inform planners, officials of educational ministries, school administrators, principals, and teachers about educational outcome measurements. In outline and graphic form, the guide presents topics for discussion in a seminar dealing with the application of outcome…

  19. Improving Mathematical Problem Solving in Grades 4 through 8. IES Practice Guide. NCEE 2012-4055

    ERIC Educational Resources Information Center

    Woodward, John; Beckmann, Sybilla; Driscoll, Mark; Franke, Megan; Herzig, Patricia; Jitendra, Asha; Koedinger, Kenneth R.; Ogbuehi, Philip

    2012-01-01

    The Institute of Education Sciences (IES) publishes practice guides in education to bring the best available evidence and expertise to bear on current challenges in education. Authors of practice guides combine their expertise with the findings of rigorous research, when available, to develop specific recommendations for addressing these…

  20. Occupational Education for Students with Special Needs: Building Trades.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on building trades is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach job-required…

  1. Curriculum Guide for the Education of Gifted High School Students.

    ERIC Educational Resources Information Center

    Curry, James; Samara, John

    This guide, based on the Texas Education Agency's "essential elements," presents a model for providing differentiated instruction for gifted high school students in any area of content and within any educational setting. The guide provides strategies for changing the following dimensions of the curriculum: (1) content or subject matter,…

  2. Occupational Education for Students with Special Needs: Personal Services, Housekeeping Oriented.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum guide on housekeeping oriented personal services is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to…

  3. Career Education Resource Guide for Physics. (Tentative.)

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge.

    The career education resource guide integrates learning activities in basic physics with an exploration of careers in physics or related fields. The guide is keyed to the physics textbooks and laboratory manuals adopted by the Louisiana State Department of Education in 1973. The field of physics is divided into six subject areas: (1) the…

  4. Occupational Education for Students with Special Needs: Office Services.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on office services is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach job-required…

  5. Teens as Parents of Babies and Toddlers: A Resource Guide for Educators. Revised Edition.

    ERIC Educational Resources Information Center

    Birckmayer, Jennifer; Mabb, Katherine; Westendorf, Bonnie-Jo; Wilson, Jerridith

    Providing effective parent education for teen parents can be a challenge for educators. This guide for cooperative extension facilitators provides workshop outlines for teen parents regarding their social world, infant and toddler development, and health and safety. The guide's introduction discusses the challenges of parenting, the Eriksonian…

  6. Occupational Education for Students with Special Needs: Food Services.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on food services is one of a series of seventeen specialized curriculum guides for occupational education of the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to teach job-required…

  7. Occupational Education for Students with Special Needs: Personal Services, Health Oriented.

    ERIC Educational Resources Information Center

    Nassau County Board of Cooperative Educational Services, Westbury, NY.

    This curriculum resource guide on health oriented personal services is one of a series of seventeen specialized curriculum guides for occupational education for the marginal, handicapped, or special needs occupational education student. The guide begins with six behavior clusters that contain a series of forty-two instructional topics designed to…

  8. Exploration Guides as a Strategy to Improve the Effectiveness of Educational Software in Chemistry

    ERIC Educational Resources Information Center

    Paiva, Joao Carlos; da Costa, Luiza Alves

    2010-01-01

    Guiding students while they explore educational software is important in order to convey the pedagogical pragmatism that many programs seem to lack. This article points out some characteristics that we believe educational software exploration guides must contain for students to benefit from using these programs. The supporting information includes…

  9. English Learners (ELs) Who Are Native Hawaiian or Other Pacific Islander (NHPI). Fast Facts

    ERIC Educational Resources Information Center

    Office of English Language Acquisition, US Department of Education, 2015

    2015-01-01

    The Office of English Language Acquisition (OELA) has synthesized key data on English learners (ELs) into two-page PDF sheets, by topic, with graphics, plus key contacts. The topics for this report on English Learners (ELs) who are Native Hawaiian or Other Pacific Islander (NHPI) include: (1) Local Education Agencies (LEAs) With the Largest Number…

  10. Smithsonian Education - Families - Activity Sheets

    Science.gov Websites

    United States and design your own flag to represent you! Download and print The True Story of the Star ? See lunch boxes from the Smithsonian and design your own! Download and print It's Pop Culture, Kid Be President (PDF). The True Story of the Star-Spangled Banner The True Story of the Star-Spangled

  11. Nurses Christian Fellowship International: Partners in Care.

    PubMed

    White, Barbara

    2013-01-01

    The Nurses Christian Fellowship International Quadrennial Conference was held November 5-10, 2012, in Santiago, Chile. The theme, "Partners in Care: Unity in diversity through Christ" brought together nurses from all over the world for Bible teaching, education, networking, and fellowship. Plenary and session abstracts are available as supplemental digital content through the HTML and PDF versions of this article at journalofchristiannursing.com.

  12. 75 FR 13735 - Fund for the Improvement of Postsecondary Education (FIPSE)-Special Focus Competition: Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and.... Electronic Access to This Document: You can view this document, as well as all other documents of this... Internet at the following site: http://www.ed.gov/news/fedregister . To use PDF you must have Adobe Acrobat...

  13. Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI.

    PubMed

    Cai, Jing; Read, Paul W; Altes, Talissa A; Molloy, Janelle A; Brookeman, James R; Sheng, Ke

    2007-01-21

    Treatment planning based on probability distribution function (PDF) of patient geometries has been shown a potential off-line strategy to incorporate organ motion, but the application of such approach highly depends upon the reproducibility of the PDF. In this paper, we investigated the dependences of the PDF reproducibility on the imaging acquisition parameters, specifically the scan time and the frame rate. Three healthy subjects underwent a continuous 5 min magnetic resonance (MR) scan in the sagittal plane with a frame rate of approximately 10 f s-1, and the experiments were repeated with an interval of 2 to 3 weeks. A total of nine pulmonary vessels from different lung regions (upper, middle and lower) were tracked and the dependences of their displacement PDF reproducibility were evaluated as a function of scan time and frame rate. As results, the PDF reproducibility error decreased with prolonged scans and appeared to approach equilibrium state in subjects 2 and 3 within the 5 min scan. The PDF accuracy increased in the power function with the increase of frame rate; however, the PDF reproducibility showed less sensitivity to frame rate presumably due to the randomness of breathing which dominates the effects. As the key component of the PDF-based treatment planning, the reproducibility of the PDF affects the dosimetric accuracy substantially. This study provides a reference for acquiring MR-based PDF of structures in the lung.

  14. Curriculum Guide for Drafting Communication in Technology Education.

    ERIC Educational Resources Information Center

    Connecticut Industrial Technology Association.

    Consistent with the principles of the Connecticut Common Core of Learning, this competency-based curriculum guide for drafting provides a reference guide for educators to research and prepare for teaching the field of drafting communications. The guide contains 44 units in three levels. The introductory level covers the following topics:…

  15. Biology, Environmental Education Guide.

    ERIC Educational Resources Information Center

    Project I-C-E, Green Bay, WI.

    This biology guide, for use at the secondary level, is one of a series of guides, K-12, which were developed by teachers to help introduce environmental education into the total curriculum. The guides are supplementary in design, containing a series of episodes (minilessons) that emphasize experimentation and discussion relating to environmental…

  16. Curriculum Guide for Electronics in Technology Education.

    ERIC Educational Resources Information Center

    Connecticut Industrial Technology Association.

    Consistent with the principles of the Connecticut Common Core of Learning, this competency-based curriculum guide for electronics provides a reference guide for educators to research and prepare for teaching the field of electronics. The guide contains 22 units that cover the following topics: theory of matter; safety; direct current; magnetism;…

  17. 32 CFR 65.5 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .../corres/pdf/133605p.pdf) and DoD Instruction 7730.54 (available at http://www.dtic.mil/whs/directives/corres/pdf/773054p.pdf) and listed in table 1 of appendix A to this part, when specified. A Military...

  18. Phase III Archives | NOAA Gulf Spill Restoration

    Science.gov Websites

    III Early Restoration Plan and Draft Early Restoration PEIS Executive Summary (pdf, 3.4 MB) Project Summary Table (pdf, 80 KB) Public Repositories (pdf, 113 KB) Press Release (pdf, 501 KB) Press Release

  19. 32 CFR 158.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... guidance in DoD Directive 3020.49 (see http://www.dtic.mil/whs/directives/corres/pdf/302049p.pdf) and the authority in DOD Directive 5134.01 (see http://www.dtic.mil/whs/directives/corres/pdf/513401p.pdf). ...

  20. 32 CFR 158.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... guidance in DoD Directive 3020.49 (see http://www.dtic.mil/whs/directives/corres/pdf/302049p.pdf) and the authority in DOD Directive 5134.01 (see http://www.dtic.mil/whs/directives/corres/pdf/513401p.pdf). ...

  1. 32 CFR 158.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... guidance in DoD Directive 3020.49 (see http://www.dtic.mil/whs/directives/corres/pdf/302049p.pdf) and the authority in DOD Directive 5134.01 (see http://www.dtic.mil/whs/directives/corres/pdf/513401p.pdf). ...

  2. PDF approach for compressible turbulent reacting flows

    NASA Technical Reports Server (NTRS)

    Hsu, A. T.; Tsai, Y.-L. P.; Raju, M. S.

    1993-01-01

    The objective of the present work is to develop a probability density function (pdf) turbulence model for compressible reacting flows for use with a CFD flow solver. The probability density function of the species mass fraction and enthalpy are obtained by solving a pdf evolution equation using a Monte Carlo scheme. The pdf solution procedure is coupled with a compressible CFD flow solver which provides the velocity and pressure fields. A modeled pdf equation for compressible flows, capable of capturing shock waves and suitable to the present coupling scheme, is proposed and tested. Convergence of the combined finite-volume Monte Carlo solution procedure is discussed, and an averaging procedure is developed to provide smooth Monte-Carlo solutions to ensure convergence. Two supersonic diffusion flames are studied using the proposed pdf model and the results are compared with experimental data; marked improvements over CFD solutions without pdf are observed. Preliminary applications of pdf to 3D flows are also reported.

  3. 77 FR 38831 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on June 4, 2012, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... research project. Membership in this group research project remains open, and 3D PDF intends to file...

  4. Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C.

    PubMed

    Alexander, Bobby; Fishman, Andrew I; Eshghi, Majid; Choudhury, Muhammad; Konno, Sensuke

    2013-09-01

    Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available, the unsatisfactory outcomes demand establishing more effective interventions. D-fraction (PDF), a bioactive proteoglucan of Maitake mushroom, demonstrates anticancer and immunomodulatory activities, which are also shown to be potentiated by vitamin C (VC). We thus hypothesized that a combination of PDF and VC (PDF + VC) could be an alternative approach to more effectively inhibit the growth of RCC. We examined the dose-dependent effects of PDF + VC on RCC cell viability and also performed biochemical assays to explore the growth regulatory mechanism. Human RCC, ACHN cell line, was employed and exposed to varying concentrations of PDF or VC and their combinations. Cell viability at specified times was determined by MTT assay. Lipid peroxidation assay, cell cycle analysis, and Western blot analysis were also performed. PDF or VC alone led to the significant reduction in cell viability at 72 hours with PDF >500 µg/mL and VC ≥300 µM. When various combinations of PDF and VC were tested, the combination of the ineffective concentrations of PDF (300 µg/mL) and VC (200 µM) resulted in ~90% cell death in 24 hours. Lipid peroxidation assay then indicated significantly (~2.5 fold) elevated oxidative stress with this PDF + VC. Cell cycle analysis also indicated a G1 cell cycle arrest following a 6-hour PDF + VC treatment. Western blots further revealed a downregulation of Bcl2, an upregulation of Bax, and proteolytic activation of PARP (poly[ADP-ribose] polymerase) in PDF + VC-treated cells, indicating induction of apoptosis. The present study demonstrates that the combination of PDF and VC can become highly cytotoxic, inducing severe cell death in ACHN cells. This cytotoxic mechanism appears to be primarily attributed to oxidative stress, accompanied by a G1 cell cycle arrest. Such cell death induced by PDF + VC could be more likely linked to apoptosis, as indicated by the modulation of apoptosis regulators (Bcl2, Bax, and PARP). Therefore, as PDF and VC may work synergistically to induce apoptotic cell death, they may have clinical implications in an alternative, improved therapeutic modality for advanced RCC.

  5. Conservational PDF Equations of Turbulence

    NASA Technical Reports Server (NTRS)

    Shih, Tsan-Hsing; Liu, Nan-Suey

    2010-01-01

    Recently we have revisited the traditional probability density function (PDF) equations for the velocity and species in turbulent incompressible flows. They are all unclosed due to the appearance of various conditional means which are modeled empirically. However, we have observed that it is possible to establish a closed velocity PDF equation and a closed joint velocity and species PDF equation through conditions derived from the integral form of the Navier-Stokes equations. Although, in theory, the resulted PDF equations are neither general nor unique, they nevertheless lead to the exact transport equations for the first moment as well as all higher order moments. We refer these PDF equations as the conservational PDF equations. This observation is worth further exploration for its validity and CFD application

  6. Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.

    PubMed

    Depetris-Chauvin, Ana; Fernández-Gamba, Agata; Gorostiza, E Axel; Herrero, Anastasia; Castaño, Eduardo M; Ceriani, M Fernanda

    2014-10-01

    In the Drosophila brain, the neuropeptide PIGMENT DISPERSING FACTOR (PDF) is expressed in the small and large Lateral ventral neurons (LNvs) and regulates circadian locomotor behavior. Interestingly, PDF immunoreactivity at the dorsal terminals changes across the day as synaptic contacts do as a result of a remarkable remodeling of sLNv projections. Despite the relevance of this phenomenon to circuit plasticity and behavior, the underlying mechanisms remain poorly understood. In this work we provide evidence that PDF along with matrix metalloproteinases (Mmp1 and 2) are key in the control of circadian structural remodeling. Adult-specific downregulation of PDF levels per se hampers circadian axonal remodeling, as it does altering Mmp1 or Mmp2 levels within PDF neurons post-developmentally. However, only Mmp1 affects PDF immunoreactivity at the dorsal terminals and exerts a clear effect on overt behavior. In vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that Mmp1 could directly terminate its biological activity. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  7. Mmp1 Processing of the PDF Neuropeptide Regulates Circadian Structural Plasticity of Pacemaker Neurons

    PubMed Central

    Depetris-Chauvin, Ana; Fernández-Gamba, Ágata; Gorostiza, E. Axel; Herrero, Anastasia; Castaño, Eduardo M.; Ceriani, M. Fernanda

    2014-01-01

    In the Drosophila brain, the neuropeptide PIGMENT DISPERSING FACTOR (PDF) is expressed in the small and large Lateral ventral neurons (LNvs) and regulates circadian locomotor behavior. Interestingly, PDF immunoreactivity at the dorsal terminals changes across the day as synaptic contacts do as a result of a remarkable remodeling of sLNv projections. Despite the relevance of this phenomenon to circuit plasticity and behavior, the underlying mechanisms remain poorly understood. In this work we provide evidence that PDF along with matrix metalloproteinases (Mmp1 and 2) are key in the control of circadian structural remodeling. Adult-specific downregulation of PDF levels per se hampers circadian axonal remodeling, as it does altering Mmp1 or Mmp2 levels within PDF neurons post-developmentally. However, only Mmp1 affects PDF immunoreactivity at the dorsal terminals and exerts a clear effect on overt behavior. In vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that Mmp1 could directly terminate its biological activity. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior. PMID:25356918

  8. Deep PDF parsing to extract features for detecting embedded malware.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Munson, Miles Arthur; Cross, Jesse S.

    2011-09-01

    The number of PDF files with embedded malicious code has risen significantly in the past few years. This is due to the portability of the file format, the ways Adobe Reader recovers from corrupt PDF files, the addition of many multimedia and scripting extensions to the file format, and many format properties the malware author may use to disguise the presence of malware. Current research focuses on executable, MS Office, and HTML formats. In this paper, several features and properties of PDF Files are identified. Features are extracted using an instrumented open source PDF viewer. The feature descriptions of benignmore » and malicious PDFs can be used to construct a machine learning model for detecting possible malware in future PDF files. The detection rate of PDF malware by current antivirus software is very low. A PDF file is easy to edit and manipulate because it is a text format, providing a low barrier to malware authors. Analyzing PDF files for malware is nonetheless difficult because of (a) the complexity of the formatting language, (b) the parsing idiosyncrasies in Adobe Reader, and (c) undocumented correction techniques employed in Adobe Reader. In May 2011, Esparza demonstrated that PDF malware could be hidden from 42 of 43 antivirus packages by combining multiple obfuscation techniques [4]. One reason current antivirus software fails is the ease of varying byte sequences in PDF malware, thereby rendering conventional signature-based virus detection useless. The compression and encryption functions produce sequences of bytes that are each functions of multiple input bytes. As a result, padding the malware payload with some whitespace before compression/encryption can change many of the bytes in the final payload. In this study we analyzed a corpus of 2591 benign and 87 malicious PDF files. While this corpus is admittedly small, it allowed us to test a system for collecting indicators of embedded PDF malware. We will call these indicators features throughout the rest of this report. The features are extracted using an instrumented PDF viewer, and are the inputs to a prediction model that scores the likelihood of a PDF file containing malware. The prediction model is constructed from a sample of labeled data by a machine learning algorithm (specifically, decision tree ensemble learning). Preliminary experiments show that the model is able to detect half of the PDF malware in the corpus with zero false alarms. We conclude the report with suggestions for extending this work to detect a greater variety of PDF malware.« less

  9. Distance Education Techniques to Assist Skills of Tourist Guides

    ERIC Educational Resources Information Center

    Sahin, Yasar Guneri; Balta, Sabah

    2007-01-01

    This study is a presentation of the usage of distance education technologies in a bid to support face to face education of tourist guide candidates during the training tour. The laws require tourist guide candidates to successfully complete their internship tour and get a certificate. Since the time in this internship period is limited and there…

  10. Washington State Guide to Planning, Implementing and Improving Work-based Learning. A Guide for Educators at All Levels.

    ERIC Educational Resources Information Center

    Highline Community Coll., Des Moines, WA.

    This guide, which is intended primarily for school and college personnel interested in initiating or improving work-based learning, examines the development and implementation of work-based education programs in Washington. The following topics are discussed: the rationale for work-based learning (legislative and educational change information,…

  11. Workshop on Survey Methods in Education Research: Facilitator's Guide and Resources. REL 2017-214

    ERIC Educational Resources Information Center

    Walston, Jill; Redford, Jeremy; Bhatt, Monica P.

    2017-01-01

    This Workshop on Survey Methods in Education Research tool consists of a facilitator guide and workshop handouts. The toolkit is intended for use by state or district education leaders and others who want to conduct training on developing and administering surveys. The facilitator guide provides materials related to various phases of the survey…

  12. Real Estate Education: A Curriculum Guide for a Two-year Post Secondary Program.

    ERIC Educational Resources Information Center

    Overton, R. Jean

    This curriculum guide was designed to assist in the development of associate degree programs and/or options for real estate education in North Carolina community colleges. The real estate education program prescribed by this guide spans six academic quarters. The 28 courses listed cover such subject areas as real estate fundamentals, human…

  13. Generating Outcome Measurements: Achievement and Attitudes. A Guide to Educational Outcome Measurements and Their Uses. Seminar No. 3.

    ERIC Educational Resources Information Center

    Mushkin, Selma J.; Billings, Bradley B.

    This guide is essentially designed as a teaching aid for those who would inform planners, officials of educational ministries, school administrators, principals, and teachers about educational outcome measurements. In outline and graphic form, the guide presents topics for discussion in a seminar dealing with how to obtain information on…

  14. Feedback Consequences and Steps Toward Implementation: A Guide to Educational Outcome Measurements and Their Uses. Seminar No. 6.

    ERIC Educational Resources Information Center

    Mushkin, Selma J.; Billings, Bradley B.

    This guide is essentially designed as a teaching aid for those who would inform planners, officials of educational ministries, school administrators, principals, and teachers about educational outcome measurements. In outline and graphic form, the guide presents topics for discussion in a seminar dealing with feedback consequences and steps toward…

  15. Generating Outcome Measurements: Economic and Societal. A Guide to Educational Outcomes Measurements and Their Uses. Seminar No. 4.

    ERIC Educational Resources Information Center

    Mushkin, Selma J.; Billings, Bradley B.

    This guide is essentially designed as a teaching aid for those who would inform planners, officials of educational ministires, school administrators, principals, and teachers about educational outcome measurements. In outline and graphic form, the guide presents topics for discussion in a seminar dealing with generating outcome measurements:…

  16. Life Journey through Autism: An Educator's Guide to Asperger Syndrome

    ERIC Educational Resources Information Center

    Myles, Brenda Smith; Hagen, Kristen; Holverstott, Jeanne; Hubbard, Anastasia; Adreon, Diane; Trautman, Melissa

    2005-01-01

    The purpose of this guide is to help educators understand and be able to respond effectively to the needs of children with Asperger Syndrome in an inclusive classroom setting. This guide is meant to orient educators to the challenges and skills of students with Asperger Syndrome and outline strategies that can be easily implemented to meet their…

  17. Peace and World Order Education: A Study Guide/Mini Course.

    ERIC Educational Resources Information Center

    Institute for World Order, New York, NY.

    This study guide may be used as a reader for exploratory discussions among college students and educators interested in peace, world order, and global change studies. The essays and reprints of journal articles in the guide are general introductions to the issues covered by world order education. The first article, "World Resources and the…

  18. Drug Education Curriculum, Junior High. Health Education: Substance Abuse Prevention. Revised 1982.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Health and Drug Education and Services.

    This junior high school level curriculum guide on drug education is a revision of a 1981 guide. It is one of nine sequential guides for elementary and secondary teachers and administrators designed to prevent drug misuse and abuse through combined cognitive and affective development. The affective model upon which this curriculum is based has…

  19. Teaching Elementary School Students to Be Effective Writers: Instructional Tips Based on the Educator's Practice Guide

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2017

    2017-01-01

    Instructional tips help educators carry out recommendations contained in IES Educator's Practice Guides. The tips, based on a practice guide authored by Steve Graham, Alisha Bollinger, Carol Booth Olson, Catherine D'Aoust, Charles MacArthur, Deborah McCutchen, and Natalie Olinghouse, translate these recommendations into actionable approaches that…

  20. Physical Education Curriculum Guide. Second and Third Grades. 1977-78.

    ERIC Educational Resources Information Center

    Saul, Fran C.; Paris, Jalie

    This physical education curriculum guide was developed for use in grade 2 and grade 3 in the Duval County Public Schools, Jacksonville, Florida. A short discussion of administrative policies is followed by a suggested yearly program and a listing of essential skills. The greater part of the guide is devoted to sections on (1) movement education;…

  1. Web Standard: PDF - When to Use, Document Metadata, PDF Sections

    EPA Pesticide Factsheets

    PDF files provide some benefits when used appropriately. PDF files should not be used for short documents ( 5 pages) unless retaining the format for printing is important. PDFs should have internal file metadata and meet section 508 standards.

  2. Whittier Tunnel, Transportation & Public Facilities, State of Alaska

    Science.gov Websites

    ONLINE (or choose to download in Adobe PDF or Excel format) Summer May 1 - Sept 30 PDF document | Excel document Winter Oct 1 - Apr 30 PDF document | Excel document Current Regulations: PDF document | Word

  3. Floods - Multiple Languages

    MedlinePlus

    ... Arabic (العربية) Expand Section Floods and Flash Flooding - English PDF Floods and Flash Flooding - العربية (Arabic) PDF ... Bosnian (bosanski) Expand Section Floods and Flash Flooding - English PDF Floods and Flash Flooding - bosanski (Bosnian) PDF ...

  4. ISER - Electric Disturbance Events (OE-417)

    Science.gov Websites

    Training. (PDF 1.1 MB) (DOC 1 MB) OE-417 Form and Instructions Survey Form (PDF 136 KB) ( DOC 104 KB) Form Instructions (PDF 383 KB) (DOC 104 KB) Annual Summaries Current Year Summary (PDF 71 KB) (XLS 43 KB) Archives -417 Survey Form E-Filing System Training. (PDF 1.1 MB) (DOC 1 MB) OE-417 FORM AND INSTRUCTIONS Survey

  5. Relationship between Two Types of Coil Packing Densities Relative to Aneurysm Size.

    PubMed

    Park, Keun Young; Kim, Byung Moon; Ihm, Eun Hyun; Baek, Jang Hyun; Kim, Dong Joon; Kim, Dong Ik; Huh, Seung Kon; Lee, Jae Whan

    2015-01-01

    Coil packing density (PD) can be calculated via a formula (PDF ) or software (PDS ). Two types of PD can be different from each other for same aneurysm. This study aimed to evaluate the interobserver agreement and relationships between the 2 types of PD relative to aneurysm size. Consecutive 420 saccular aneurysms were treated with coiling. PD (PDF , [coil volume]/[volume calculated by formula] and PDS, [coil volume]/[volume measured by software]) was calculated and prospectively recorded. Interobserver agreement was evaluated between PDF and PDS . Additionally, the relationships between PDF and PDS relative to aneurysm size were subsequently analyzed. Interobserver agreement for PDF and PDS was excellent (Intraclass correlation coefficient, PDF ; 0.967 and PDS ; 0.998). The ratio of PDF and PDS was greater for smaller aneurysms and converged toward 1.0 as the maximum dimension (DM ) of aneurysm increased. Compared with PDS , PDF was overestimated by a mean of 28% for DM < 5 mm, by 17% for 5 mm ≤ DM < 10 mm, and by 9% for DM ≥ 10 mm (P < 0.01). Interobserver agreement for PDF and PDS was excellent. However, PDF was overestimated in smaller aneurysms and converged to PDS as aneurysm size increased. Copyright © 2014 by the American Society of Neuroimaging.

  6. A compression algorithm for the combination of PDF sets.

    PubMed

    Carrazza, Stefano; Latorre, José I; Rojo, Juan; Watt, Graeme

    The current PDF4LHC recommendation to estimate uncertainties due to parton distribution functions (PDFs) in theoretical predictions for LHC processes involves the combination of separate predictions computed using PDF sets from different groups, each of which comprises a relatively large number of either Hessian eigenvectors or Monte Carlo (MC) replicas. While many fixed-order and parton shower programs allow the evaluation of PDF uncertainties for a single PDF set at no additional CPU cost, this feature is not universal, and, moreover, the a posteriori combination of the predictions using at least three different PDF sets is still required. In this work, we present a strategy for the statistical combination of individual PDF sets, based on the MC representation of Hessian sets, followed by a compression algorithm for the reduction of the number of MC replicas. We illustrate our strategy with the combination and compression of the recent NNPDF3.0, CT14 and MMHT14 NNLO PDF sets. The resulting compressed Monte Carlo PDF sets are validated at the level of parton luminosities and LHC inclusive cross sections and differential distributions. We determine that around 100 replicas provide an adequate representation of the probability distribution for the original combined PDF set, suitable for general applications to LHC phenomenology.

  7. Delivering Hubble Discoveries to the Classroom

    NASA Astrophysics Data System (ADS)

    Eisenhamer, B.; Villard, R.; Weaver, D.; Cordes, K.; Knisely, L.

    2013-04-01

    Today's classrooms are significantly influenced by current news events, delivered instantly into the classroom via the Internet. Educators are challenged daily to transform these events into student learning opportunities. In the case of space science, current news events may be the only chance for educators and students to explore the marvels of the Universe. Inspired by these circumstances, the education and news teams developed the Star Witness News science content reading series. These online news stories (also available in downloadable PDF format) mirror the content of Hubble press releases and are designed for upper elementary and middle school level readers to enjoy. Educators can use Star Witness News stories to reinforce students' reading skills while exposing students to the latest Hubble discoveries.

  8. Competency Based Curriculum Guide for Practical Nursing Education in Virginia. Final Report.

    ERIC Educational Resources Information Center

    Old Dominion Univ., Norfolk, VA. Dept. of Industrial Arts Education.

    This final report contains a three-page narrative and extensive appendixes, including correspondence, surveys, field test evaluation and guide, and the Competency-Based Curriculum Guide for Practical Nursing Education in Virginia developed by the project. The over 200-page curriculum guide presents a suggested master curriculum for a twelve or…

  9. Home Economics 7-12, Environmental Education Guide.

    ERIC Educational Resources Information Center

    Project I-C-E, Green Bay, WI.

    This home economics guide, for use at the secondary level, is one of a series of guides, K-12, that were developed by teachers to help introduce environmental education into the total curriculum. The guides are supplementary in design, containing a series of episodes that develop a sense of family and personal responsibility toward the environment…

  10. Curriculum Guide for Maximizing Student Potential in Required Subject Areas.

    ERIC Educational Resources Information Center

    Richert, E. Susanne

    This curriculum guide is intended to assist educators to maximize the performance of gifted students and others in required subject areas and is keyed to initiatives of the Kansas State Board of Education (KSBE). Part 1, the introduction, describes the guide's development, states the guide's purpose, specifies the students to be served, and…

  11. Working with the Pregnant Teenager: A Guide for Nutrition Educators. Program Aid Number 1303.

    ERIC Educational Resources Information Center

    Food and Nutrition Service (USDA), Washington, DC.

    This guide is designed primarily for nutritionists and other health providers who work with pregnant adolescents, aged 17 or younger. The guide lists psychosocial, educational, and health implications of early pregnancy, and discusses the nutritional risks and requirements of pregnant teenagers. The guide then identifies counseling and educational…

  12. Law 20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of law. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials include a…

  13. Marketing 20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of marketing. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials include a…

  14. Apparel. Vocational Home Economics Education.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This curriculum guide for apparel is one of a number of guides developed for use in vocational home economics education in Texas. Introductory materials address use of the guide and list the essential elements upon which the content is based. The guide is divided into six units: individual and family apparel decisions, apparel management,…

  15. Shorthand 20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of shorthand. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials include a…

  16. Basic Business 20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of basic business. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials…

  17. Office Procedures 20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of office procedures. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials…

  18. Future Aspiring Aviators, Primary: An Aviation Curriculum Guide K-3

    DOT National Transportation Integrated Search

    1995-01-01

    Prepared ca. 1995. The Federal Aviation Administration is pleased to present the Aviation Education Teacher's Guide Series. The series includes four publications specifically designed as resources to those interested in aviation education. The guides...

  19. Health Education for Special Children: Intermediate EMR.

    ERIC Educational Resources Information Center

    Brodie, Patrick; And Others

    Intended for teachers and administrators in special education, the curriculum guide offers information on planning a health education program for educable mentally retarded children in intermediate grades. Sections preceding the actual guide include information on specific goals of and elements necessary for a successful health education program,…

  20. Health Education for Special Children: Primary EMR.

    ERIC Educational Resources Information Center

    Allen, Linda; And Others

    Intended for teachers and administrators in special education, the curriculum guide offers information on planning a health education program for primary level educable mentally retarded students. Sections preceding the actual guide include information on specific goals of and elements necessary for a successful health education program, the…

  1. A Guide To Aviation Education Resources.

    ERIC Educational Resources Information Center

    National Coalition for Aviation Education, Washington, DC.

    This guide to aviation education resources was compiled by the National Coalition for Aviation Education (NCAE) which represents government, industry, and labor. NCAE's mission is to: (1) promote aviation education activities and resources; (2) increase public understanding of the importance of aviation; and (3) support educational initiatives at…

  2. Fire Safety - Multiple Languages

    MedlinePlus

    ... Arabic (العربية) Expand Section Fire Safety at Home - English PDF Fire Safety at Home - العربية (Arabic) PDF ... Bosnian (bosanski) Expand Section Fire Safety at Home - English PDF Fire Safety at Home - bosanski (Bosnian) PDF ...

  3. A Comprehensive Restoration Plan for the Gulf of Mexico | NOAA Gulf Spill

    Science.gov Websites

    Consequences and Compliance with Other Laws (pdf, 12 MB) Chapter 7: Governance (pdf, 7.42 MB) Chapter 7 : Governance (pdf, 7.42 MB) (Vietnamese translation) Chapter 8: Trustee Responses to Public Comments (pdf, 537

  4. An Administrator's Guide to Online Education. The USDLA Book Series on Distance Learning

    ERIC Educational Resources Information Center

    Shelton, Kaye, Ed.; Saltsman, George, Ed.

    2005-01-01

    An Administrator's Guide to Online Education is an essential resource for the higher education administrator. Unlike most books regarding online education, this book is not about teaching; it is about effectively administrating an online education program. Grounded in existing distance education theory, and drawing from best practices, current…

  5. Handbook of Procedural Guidelines for Implementation of Special Education Curriculum: Critical Skills/Community-Based and Special Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Riverside County Office of Education, CA. Div. of Special Schools and Services.

    The special education procedural handbook and the special education curriculum guide provide guidelines for teachers and other school personnel. The procedural handbook covers the following areas: individual education program process (IEP) and program placement, individual education program team, administrative placements, parent interviews,…

  6. E AND M CIRCADIAN PACEMAKER NEURONS USE DIFFERENT PDF RECEPTOR SIGNALOSOME COMPONENTS IN DROSOPHILA

    PubMed Central

    Duvall, Laura B.

    2014-01-01

    We used real-time imaging to detect cAMP levels in neurons of intact fly brains to study mechanisms of circadian pacemaker synchronization by the neuropeptide PDF in Drosophila. PDF receptor (PDF-R) is expressed by both M (sLNv) and E (LNd) pacemaker sub-classes and is coupled to Gsα in both cases. We previously reported that PDF-R in M pacemakers elevates cAMP levels by activating the ortholog of mammalian Adenylate Cyclase 3 (AC3), but that AC3 disruptions had no effect on E pacemaker sensitivity to PDF. Here we show that PDF-R in E pacemakers activates a different AC isoform, AC78C, an ortholog of mammalian AC8. Knockdown of AC78C by transgenic RNAi substantially reduces, but does not completely abrogate, PDF responses in these E pacemakers. The knockdown effect is intact when restricted to mature stages, suggesting a physiological and not a development role for AC78C in E pacemakers. The AC78C phenotype is rescued by over-expression of AC78C, but not by over-expression of the rutabaga AC. AC78C over-expression does not disrupt PDF responses in these E pacemakers, and neither AC78C knockdown nor its over-expression disrupted locomotor rhythms. Finally, knockdown of two AKAPs, nervy and AKAP 200 partially reduces LNd PDF responses. These findings begin to identify the components of E pacemaker PDF-R signalosomes and indicate they are distinct from PDF-R signalosomes in M pacemakers: we propose they contain AC78C and at least one other AC. PMID:23929551

  7. E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila.

    PubMed

    Duvall, Laura B; Taghert, Paul H

    2013-08-01

    We used real-time imaging to detect cAMP levels in neurons of intact fly brains to study the mechanisms of circadian pacemaker synchronization by the neuropeptide pigment dispersing factor (PDF) in Drosophila. PDF receptor (PDF-R) is expressed by both M (sLNv) and E (LNd) pacemaker subclasses and is coupled to G(sα) in both cases. We previously reported that PDF-R in M pacemakers elevates cAMP levels by activating the ortholog of mammalian adenylate cyclase 3 (AC3) but that AC3 disruptions had no effect on E pacemaker sensitivity to PDF. Here, we show that PDF-R in E pacemakers activates a different AC isoform, AC78C, an ortholog of mammalian AC8. Knockdown of AC78C by transgenic RNAi substantially reduces, but does not completely abrogate, PDF responses in these E pacemakers. The knockdown effect is intact when restricted to mature stages, suggesting a physiological and not a development role for AC78C in E pacemakers. The AC78C phenotype is rescued by the overexpression of AC78C but not by overexpression of the rutabaga AC. AC78C overexpression does not disrupt PDF responses in these E pacemakers, and neither AC78C knockdown nor its overexpression disrupted locomotor rhythms. Finally, knockdown of 2 AKAPs, nervy and AKAP200, partially reduces LNd PDF responses. These findings begin to identify the components of E pacemaker PDF-R signalosomes and indicate that they are distinct from PDF-R signalosomes in M pacemakers: we propose they contain AC78C and at least 1 other AC.

  8. 32 CFR 159.6 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...://www.dtic.mil/whs/directives/corres/pdf/520008r.pdf. 10 Available athttp://www.dtic.mil/whs/directives... hostile acts or demonstrated hostile intent. 11 Available athttp://www.dtic.mil/whs/directives/corres/pdf/110022p.pdf. (D) Documentation of individual training covering weapons familiarization and qualification...

  9. Creating Customizable Subject Guides at Your Library to Support Online, Distance and Traditional Education: Comparing Three Self-Developed and One Commercial Online Subject Guide

    ERIC Educational Resources Information Center

    Robinson, Julie; Kim, Don

    2010-01-01

    This article compares three self-developed subject guides and one commercial online subject guide (LibGuides) to provide information to other institutions which have a plan or are in the process of developing a plan to implement similar services to support online, distance and traditional education. This is a comparison of the current subject…

  10. Evaluating Preparation Programs for School Leaders and Teachers in Specialty Areas.

    ERIC Educational Resources Information Center

    Berney, Mary F., Ed.; Ayers, Jerry B., Ed.

    This book is a guide to evaluating the educational programs for preparation of school administrators, school counselors and psychologists, school library media specialists, vocational education teachers, special education teachers, health and physical education teachers, and music and visual arts education teachers. It is a practical guide to the…

  11. Flying Ace Activities: Aviation Curriculum Guide for Middle Grade Levels 4-6

    DOT National Transportation Integrated Search

    1995-01-01

    Prepared ca. 1995. The Federal Aviation Administration is pleased to present the Aviation Education Teacher's Guide Series. The series includes four publications specifically designed as resources to those interested in aviation education. The guides...

  12. Volunteeer's Reference Guide.

    ERIC Educational Resources Information Center

    Armstrong, Julie; And Others

    For Postpartum Education for Parents (PEP) volunteers, this reference guide provides background information about the common concerns of parents. Extensively reviewed for accuracy and content by pediatricians, psychologists, obstetricians, nurses, and childbirth educators, the guide contains a summary discussion of the postpartum infant and…

  13. A Curriculum Guide for Primary and Intermediate Special Education in the Opelika City Schools. Revised Edition.

    ERIC Educational Resources Information Center

    Opelika City Schools, AL.

    Presented is a curriculum guide for primary and intermediate special education in the areas of communication skills, arithmetic, science, and physical education. The guide, prepared by the Opelika (Alabama) schools, is said to be based on assumptions such as the values of structured individualized learning, use of materials which do not require…

  14. Industrial Enterprise Handbook. The Wisconsin Guide to Local Curriculum Improvement in Industrial Education, K-12.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison. Div. of Instructional Services.

    This handbook is designed to aid industrial educators in developing a private enterprise component in their programs in order to help students learn how business and industry work. It is a guide to implementing The Wisconsin Guide to Local Curriculum Improvement in Industrial Education, K-12. The book contains the following three sections: (1)…

  15. Environmental Education Guide, Volume 3: An Environmental/Energy Education Primer for Grades Seven through Nine, 1981-84.

    ERIC Educational Resources Information Center

    Sly, Carolie; Rose, Larry

    As one of four volumes in a K-12 series, this teaching guide contains classroom and outdoor activities pertaining to the environment and energy for seventh through ninth grades. The guide was developed based upon the understanding that environmental education can serve as an instructional umbrella covering many topics (conservation, marine…

  16. Environmental Education Guide, Volume 2: An Environmental/Energy Education Primer for Grades Four through Six, 1981-1984.

    ERIC Educational Resources Information Center

    Sly, Carolie; Rose, Larry

    As one of four volumes in a K-12 series, this teaching guide contains classroom and outdoor activities pertaining to the environment and energy for fourth through sixth grades. The guide was developed based upon the understanding that environmental education can serve as an instructional umbrella covering many topics (conservation, marine…

  17. Environmental Education Guide, Volume 4: An Environmental/Energy Education Primer for Grades Ten through Twelve, 1981-1984.

    ERIC Educational Resources Information Center

    Sly, Carolie; Rose, Larry

    As one of four volumes in a K-12 series, this teaching guide contains classroom and outdoor activities pertaining to the environment and energy for tenth through twelfth grades. The guide was developed based upon the understanding that environmental education can serve as an instructional umbrella covering many topics (conservation, marine…

  18. Environmental Education Guide, Volume 1: An Environmental/Energy Education Primer for Kindergarten through Grade Three, 1981-1984.

    ERIC Educational Resources Information Center

    Sly, Carolie; Rose, Larry

    As one of four volumes in a K-12 series, this teaching guide contains classroom and outdoor activities pertaining to the environment and energy for kindergarten through third grades. The guide was developed based upon the understanding that environmental education can serve as an instructional umbrella covering many topics (conservation, marine…

  19. Programming Equity into Computer Education: Today's Guide to the Schools of the Future. A PEER Computer Equity Action Kit.

    ERIC Educational Resources Information Center

    Martin-McCormick, Lynda; And Others

    An advocacy packet on educational equity in computer education consists of five separate materials. A booklet entitled "Today's Guide to the Schools of the Future" contains four sections. The first section, a computer equity assessment guide, includes interview questions about school policies and allocation of resources, student and teacher…

  20. Influences on the Use of the "Fishing: Get in the Habitat! MinnAqua Leader's Guide" and Implications for Curriculum Dissemination

    ERIC Educational Resources Information Center

    Athman Ernst, Julie

    2010-01-01

    The "Fishing: Get in the Habitat! MinnAqua Leader's Guide" is a curriculum created by the Minnesota Department of Natural Resources for educators working primarily with children in grades three through five in formal and nonformal education settings. Like many agency-developed supplemental educational resources, the Leader's Guide is…

  1. Voter Education Manual for Secondary Schools and a Teacher's Guide to Student Handouts in the Voter Education Manual.

    ERIC Educational Resources Information Center

    Balasco, Alfred P.; And Others

    This classroom guide instructs secondary school students about the registration process, the voting process, and the importance of the American electoral system. The goal is to encourage students to participate in the electoral process. Although the guide focuses most heavily on the specifics of voter education in Rhode Island, it is also…

  2. A Strategy Guide for Schools and School Systems in Education for Peace and Justice.

    ERIC Educational Resources Information Center

    McGinnis, James B.

    This is a revision and update of an earlier curriculum guide designed to meet the needs of educators in implementing education for peace and justice (EPJ) in both public and religious school systems. The guide is divided into four parts, with an introductory essay presenting the goals for an EPJ program. Goals of the program include: developing…

  3. Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing Institutional Programs.

    ERIC Educational Resources Information Center

    National Academy of Sciences - National Research Council, Washington, DC. Inst. of Lab. Animal Resources.

    The Committee on Education Programs in Laboratory Animal Science (EPLAS) has prepared this guide to aid institutions in implementing an education and training program that will meet the expectations of the Public Health Service (PHS). This guide was designed to fulfill several purposes. First, it is intended to assist institutional officials and…

  4. L'alphabetisation et les femmes francophones: Guide a l'intention des formatrices (Literacy Education and Francophone Women: Guide for Teachers).

    ERIC Educational Resources Information Center

    Brown, Johanne, Ed.; And Others

    This guide, written in French and designed for literacy teachers, offers suggestions for providing appropriate literacy education for Canadian francophone women. It recommends an approach that is based on learner needs, is holistic, and focuses on the student as the principal agent of her own education. A discussion of instructional management…

  5. Education: Guide to European Organizations and Programmes. A Guide to European Organizations Involved in Education, including Individual Programmes and Projects.

    ERIC Educational Resources Information Center

    Hayes, Heledd

    This report presents a guide to European organizations involved in education, including individual programs and projects. Entries are brief as they are intended as simple outlines of the organizations or programs, but full addresses and telephone numbers are provided. Divided into four categories, the organizations listed are as follows: (1)…

  6. Recent advances in PDF modeling of turbulent reacting flows

    NASA Technical Reports Server (NTRS)

    Leonard, Andrew D.; Dai, F.

    1995-01-01

    This viewgraph presentation concludes that a Monte Carlo probability density function (PDF) solution successfully couples with an existing finite volume code; PDF solution method applied to turbulent reacting flows shows good agreement with data; and PDF methods must be run on parallel machines for practical use.

  7. Fatigue - Multiple Languages

    MedlinePlus

    ... a new window. Arabic (العربية) Expand Section Fatigue - English PDF Fatigue - العربية (Arabic) PDF American Cancer Society ... Chinese, Traditional (Cantonese dialect) (繁體中文) Expand Section Fatigue - English PDF Fatigue - 繁體中文 (Chinese, Traditional (Cantonese dialect)) PDF ...

  8. The ABCs of PDFs.

    ERIC Educational Resources Information Center

    Adler, Steve

    2000-01-01

    Explains the use of Adobe Acrobat's Portable Document Format (PDF) for school Web sites and Intranets. Explains the PDF workflow; components for Web-based PDF delivery, including the Web server, preparing content of the PDF files, and the browser; incorporating PDFs into the Web site; incorporating multimedia; and software. (LRW)

  9. Accounting 10-20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of accounting. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials include a…

  10. Advanced Food Science and Nutrition. Vocational Home Economics Education.

    ERIC Educational Resources Information Center

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This curriculum guide for advanced food science and nutrition is one of a number of guides developed for use in vocational home economics education in Texas. Introductory materials address use of the guide and list the essential elements upon which the content is based. The guide is divided into five units: the significance of nutrition, food…

  11. Exploratory Coordinated Career Education. Arkansas Public School Course Content Guide.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    This course content guide was developed in accordance with the Standards for Accreditation of Public Schools adopted by the Arkansas State Board of Education. The guide is offered as a framework upon which a curriculum can be built. Within the subject area and at each grade level, the content guide identifies skills at three instructional levels:…

  12. Junior High Business Education. Arkansas Public School Course Content Guide.

    ERIC Educational Resources Information Center

    Arkansas State Dept. of Education, Little Rock.

    This course content guide was developed in accordance with the Standards for Accreditation of Public Schools adopted by the Arkansas State Board of Education. The guide is offered as a framework upon which a curriculum can be built. Within the subject area and at each grade level, the content guide identifies skills at three instructional levels:…

  13. Computer Processing 10-20-30. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Curriculum Branch.

    This curriculum guide is one of nine such guides developed for an Alberta high school business education program. Its content covers the main subject area or strand of computer processing. Subject to the constraints outlined in the guide, the modules are to be formatted into three- or four-credit courses within each strand. Introductory materials…

  14. Parent and Student Guide to High School Superintendent Suspension Hearings.

    ERIC Educational Resources Information Center

    Advocates for Children of New York, Inc., Long Island City.

    This guide has been written to help parents represent their children at New York City Board of Education hearings. The guide explains the rights of parents and children and explains the steps a parent should take in representing the child. It only applies to regular education high school suspensions. Sections of the guide explain: (1) reasons a…

  15. Using the Food Guide Pyramid: A Resource for Nutrition Educators.

    ERIC Educational Resources Information Center

    Shaw, Anne; Fulton, Lois; Davis, Carole; Hogbin, Myrtle

    This booklet provides information to assist nutrition educators in helping their audiences use the Food Guide Pyramid to plan and prepare foods for a healthy diet. It reviews the objectives set in developing the Food Guide Pyramid and illustrates their impact on the application of the Food Guide Pyramid to planning menus. In particular, the…

  16. Virtual and Printed 3D Models for Teaching Crystal Symmetry and Point Groups

    ERIC Educational Resources Information Center

    Casas, Lluís; Estop, Euge`nia

    2015-01-01

    Both, virtual and printed 3D crystal models can help students and teachers deal with chemical education topics such as symmetry and point groups. In the present paper, two freely downloadable tools (interactive PDF files and a mobile app) are presented as examples of the application of 3D design to study point-symmetry. The use of 3D printing to…

  17. Numerical solutions of the complete Navier-Stokes equations

    NASA Technical Reports Server (NTRS)

    Hassan, H. A.

    1993-01-01

    The objective of this study is to compare the use of assumed pdf (probability density function) approaches for modeling supersonic turbulent reacting flowfields with the more elaborate approach where the pdf evolution equation is solved. Assumed pdf approaches for averaging the chemical source terms require modest increases in CPU time typically of the order of 20 percent above treating the source terms as 'laminar.' However, it is difficult to assume a form for these pdf's a priori that correctly mimics the behavior of the actual pdf governing the flow. Solving the evolution equation for the pdf is a theoretically sound approach, but because of the large dimensionality of this function, its solution requires a Monte Carlo method which is computationally expensive and slow to coverage. Preliminary results show both pdf approaches to yield similar solutions for the mean flow variables.

  18. Blocking synaptic transmission with tetanus toxin light chain reveals modes of neurotransmission in the PDF-positive circadian clock neurons of Drosophila melanogaster.

    PubMed

    Umezaki, Yujiro; Yasuyama, Kouji; Nakagoshi, Hideki; Tomioka, Kenji

    2011-09-01

    Circadian locomotor rhythms of Drosophila melanogaster are controlled by a neuronal circuit composed of approximately 150 clock neurons that are roughly classified into seven groups. In the circuit, a group of neurons expressing pigment-dispersing factor (PDF) play an important role in organizing the pacemaking system. Recent studies imply that unknown chemical neurotransmitter(s) (UNT) other than PDF is also expressed in the PDF-positive neurons. To explore its role in the circadian pacemaker, we examined the circadian locomotor rhythms of pdf-Gal4/UAS-TNT transgenic flies in which chemical synaptic transmission in PDF-positive neurons was blocked by expressed tetanus toxin light chain (TNT). In constant darkness (DD), the flies showed a free-running rhythm, which was similar to that of wild-type flies but significantly different from pdf null mutants. Under constant light conditions (LL), however, they often showed complex rhythms with a short period and a long period component. The UNT is thus likely involved in the synaptic transmission in the clock network and its release caused by LL leads to arrhythmicity. Immunocytochemistry revealed that LL induced phase separation in TIMELESS (TIM) cycling among some of the PDF-positive and PDF-negative clock neurons in the transgenic flies. These results suggest that both PDF and UNT play important roles in the Drosophila circadian clock, and activation of PDF pathway alone by LL leads to the complex locomotor rhythm through desynchronized oscillation among some of the clock neurons. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. IceCube

    Science.gov Websites

    . PDF file High pT muons in Cosmic-Ray Air Showers with IceCube. PDF file IceCube Performance with Artificial Light Sources: the road to a Cascade Analyses + Energy scale calibration for EHE. PDF file , 2006. PDF file Thorsten Stetzelberger "IceCube DAQ Design & Performance" Nov 2005 PPT

  20. Statistical Analysis of PDF's for Na Released by Photons from Solid Surfaces

    NASA Astrophysics Data System (ADS)

    Gamborino, D.; Wurz, P.

    2018-05-01

    We analyse the adequacy of three model speed PDF's previously used to describe the desorption of Na from a solid surface either by ESD or PSD. We found that the Maxwell PDF is too wide compared to measurements and non-thermal PDF's are better suited.

  1. Publications | Transportation Research | NREL

    Science.gov Websites

    Overview Thumbnail image of publication cover Sustainable TransportationPDF This overview fact sheet image of publication cover Alternative Fuels Data CenterPDF Thumbnail image of publication cover Clean CitiesPDF Thumbnail image of publication cover Fleet ToolsPDF Thumbnail image of publication cover Fuels

  2. Computer Education and Training Reference Guide.

    ERIC Educational Resources Information Center

    Edumatics Corp., Oceanport, NJ.

    Intended for use by educators, educational administrators, and directors of training within industry, this guide lists commercially available products and services in the field of computers and education. It contains descriptive information wherever possible and comparison charts designed to enable the prospective user to make a preliminary…

  3. PDF for Healthcare and Child Health Data Forms.

    PubMed

    Zuckerman, Alan E; Schneider, Joseph H; Miller, Ken

    2008-11-06

    PDF-H is a new best practices standard that uses XFA forms and embedded JavaScript to combine PDF forms with XML data. Preliminary experience with AAP child health forms shows that the combination of PDF with XML is a more effective method to visualize familiar data on paper and the web than the traditional use of XML and XSLT. Both PDF-H and HL7 Clinical Document Architecture can co-exist using the same data for different display formats.

  4. Honorable Intentions: A Parent's Guide to Educational Planning for Children with Emotional or Behavioral Disorders.

    ERIC Educational Resources Information Center

    Jordan, Dixie

    This guide to help parents work in collaboration with the school team to enhance the education of their children with emotional or behavioral disorders considers special education and related services, special education evaluation, the individualized education program (IEP), school rules and policies, day treatment, residential placement,…

  5. Cracks in the Education Pipeline: A Business Leader's Guide to Higher Education Reform

    ERIC Educational Resources Information Center

    Committee for Economic Development, 2005

    2005-01-01

    This guide provides business leaders with a starting point for establishing a dialogue on higher education reform. Business leaders have a vested interest in ensuring that our institutions of higher education remain accessible, accountable, and affordable, because higher education provides the skilled workforce that businesses increasingly need.…

  6. Institute on Career Education for the Handicapped. Instructor's Manual [and] Participant's Guide. Project RETOOL.

    ERIC Educational Resources Information Center

    Schwartz, Stuart E., Ed.

    The instructor's manual and participant's guide are designed for the Project RETOOL Institute on Career Education for the Handicapped, a program of continuing education models for teacher educators in regular and special education. The instructor's manual provides guidelines for replicating the Project RETOOL Institute. Sections on career…

  7. Harnessing Facebook for Student Engagement in Accounting Education: Guiding Principles for Accounting Students and Educators

    ERIC Educational Resources Information Center

    Stone, Gerard; Fiedler, Brenton Andrew; Kandunias, Chris

    2014-01-01

    This paper proposes principles to guide accounting students' and accounting educators' use of Facebook as an educational resource to engage students with their learning. A body of cross-disciplinary research has investigated potential applications of Facebook to invigorate student engagement. Generic guidelines for educators who are contemplating…

  8. Home Economics for Families with Limited Income Resource Supplement to the Consumer Education Curriculum Guide for Ohio.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

    Designed as a supplement to the section on the socio-economically disadvantaged in the Consumer Education Curriculum Guide for Ohio, K-12, the guide contains consumer education learning activities for use with persons of limited income. It is organized in six sections, each dealing with one of the following basic concepts: (1) the economic system,…

  9. Liability and Safety in Physical Education and Sport: A Practitioner's Guide to the Legal Aspects of Teaching and Coaching in Elementary and Secondary Schools.

    ERIC Educational Resources Information Center

    Hart, James E.; Ritson, Robert J.

    Physical education and athletic staffs have numerous opportunities to become entangled in legal disputes. The information in this guide offers guidance for safer athletic programs and management of risk while reinforcing sound educational practice. The guide provides an overview of tort liability and negligence theory, followed by a discussion of…

  10. Questions, Instructions, and Modes of Listening in the Joint Production of Guided Action: A Study of Student-Teacher Collaboration in Handicraft Education

    ERIC Educational Resources Information Center

    Ekstrom, Anna; Lindwall, Oskar; Saljo, Roger

    2009-01-01

    This article concerns a central issue in education as an institutional activity: instructions and their role in guiding student activities and understanding. In the study, we investigate the tensions between specifics and generalities in the joint production of guided action. This issue is explored in the context of handicraft education--or more…

  11. An Invaluable Resource for Supporting Transgender, Transsexual, and Gender-Nonconforming Students in School Communities: A Review of "Supporting Transgender and Transsexual Students in K-12 Schools"

    ERIC Educational Resources Information Center

    Martino, Wayne

    2013-01-01

    This essay provides a review of a resource guide written by Kristopher Wells, Gayle Roberts, and Carol Allan (2012) titled "Supporting Transgender and Transsexual Students in K-12 Schools: A Guide for Educators". The guide is an invaluable resource for educators in schools and teacher education programs.

  12. Creating Career Cluster Programs: A Guide for Oregon High Schools.

    ERIC Educational Resources Information Center

    Oregon State Dept. of Education, Salem. Career and Vocational Education Section.

    The guide was intended to provide the information needed to implement or improve an 11th and 12th grade career education cluster program. The authors suggest that the guide will be most useful in schools where a long-range plan for career education has been prepared and adopted by the local board of education, and where it has been decided to…

  13. Teaching Elementary School Students to Be Effective Writers. Summary of Evidence for Instructional Tips Based on the Educator's Practice Guide

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2017

    2017-01-01

    Instructional tips help educators carry out recommendations contained in IES Educator's Practice Guides. This summary of evidence describes the research evidence that supports the use of the instructional tips in classrooms, and is based on a practice guide authored by Steve Graham, Alisha Bollinger, Carol Booth Olson, Catherine D'Aoust, Charles…

  14. Virginia State Adult Basic Education Administrative Guide for Local Programs and Projects under the Adult Education Act, P.L. 91-230 and Amendments.

    ERIC Educational Resources Information Center

    Virginia State Dept. of Education, Richmond. Adult Education Service.

    This administrative guide was developed to provide local school divisions and other agencies operating federally funded Adult Basic Education (ABE) programs in Virginia with the purpose, requirements, and procedures for conducting these programs. The guide is divided into eleven sections. The introduction covers the purpose and scope of ABE…

  15. The 1993-94 Educational Software Preview Guide.

    ERIC Educational Resources Information Center

    Best, Anita, Ed.; Mathis, Judi, Ed.

    This guide lists favorably reviewed, commercially available, microcomputer software for instructional use in preschool through grade 12. The guide is organized by the following curriculum areas: art; business education; computers; health; instructional tools, including authoring systems, computer assisted drafting (CAD), classroom management,…

  16. Pdf - Transport equations for chemically reacting flows

    NASA Technical Reports Server (NTRS)

    Kollmann, W.

    1989-01-01

    The closure problem for the transport equations for pdf and the characteristic functions of turbulent, chemically reacting flows is addressed. The properties of the linear and closed equations for the characteristic functional for Eulerian and Lagrangian variables are established, and the closure problem for the finite-dimensional case is discussed for pdf and characteristic functions. It is shown that the closure for the scalar dissipation term in the pdf equation developed by Dopazo (1979) and Kollmann et al. (1982) results in a single integral, in contrast to the pdf, where double integration is required. Some recent results using pdf methods obtained for turbulent flows with combustion, including effects of chemical nonequilibrium, are discussed.

  17. [Practical experience about the compatibility of PDF converter in ECG information system].

    PubMed

    Yang, Gang; Lu, Weishi; Zhou, Jiacheng

    2009-11-01

    To find a way to view ECG from different manufacturers in electrocardiogram information system. Different format ECG data were transmitted to ECG center by different ways. Corresponding analysis software was used to make the diagnosis reports in the center. Then we use PDF convert to change all ECG reports into PDF format. The electrocardiogram information system manage these PDF format ECG data for clinic user. The ECG reports form several major ECG manufacturers were transformed to PDF format successfully. In the electrocardiogram information system it is freely to view the ECG figure. PDF format ECG report is a practicable way to solve the compatibility problem in electrocardiogram information system.

  18. Development of a Curriculum Guide for Consumer Education in Vocational Home Economics Classes.

    ERIC Educational Resources Information Center

    Robinson, Nancie Smith

    This curriculum guide was developed to improve the present level of living among families in West Virginia. It was intended that vocational home economics teachers combine the objectives of the guide with their own class objectives, or in the absence of consumer education in the curriculum, use the guide for the initiation of a new program or unit…

  19. The Global Energy Situation on Earth, Student Guide. Computer Technology Program Environmental Education Units.

    ERIC Educational Resources Information Center

    Northwest Regional Educational Lab., Portland, OR.

    This is the student guide in a set of five computer-oriented environmental/energy education units. Contents of this guide are: (1) Introduction to the unit; (2) The "EARTH" program; (3) Exercises; and (4) Sources of information on the energy crisis. This guide supplements a simulation which allows students to analyze different aspects of…

  20. Recreacion/Transporte. Libro del Profesor (Recreation/Transportation. Teacher's Guide). B3. CHOICE (Challenging Options in Career Education).

    ERIC Educational Resources Information Center

    Mid-Hudson Migrant Education Center, New Paltz, NY.

    Written in Spanish, this guide for the grade 2 career education unit for migrant children focuses on the fields of recreation and transportation. Like the English version, the guide covers 11 jobs--travel agent, tour guide, camp counselor, coach, usher, school bus driver, airplane pilot, trucker, mover, railroad conductor, and astronaut. Student…

  1. Kentucky Consumer & Homemaking Education. Food & Nutrition Curriculum Guide, Semester Course.

    ERIC Educational Resources Information Center

    Blankenship, Karen; And Others

    Intended for use by teachers at the high school level, this curriculum guide, which is one in a series of guides for consumer and homemaking education in Kentucky, outlines a semester special interest course in food management. The two units, comprehensive I and II, which are prerequisites for this course are found in a separate guide (CE 017…

  2. The California State Environmental Education Guide. A Curriculum Guide for Kindergarten through Sixth Grade.

    ERIC Educational Resources Information Center

    Sly, Carolie; And Others

    The purpose of this guide is to provide teachers and other educators with classroom lessons and instructional techniques that build a fundamental understanding of the environment. The guide is aimed at grades kindergarten through sixth and consists of eight instructional units and six action projects. Each unit is organized around a theme and the…

  3. Foundational Skills to Support Reading for Understanding in Kindergarten through 3rd Grade. Educator's Practice Guide. NCEE 2016-4008

    ERIC Educational Resources Information Center

    Foorman, Barbara; Beyler, Nicholas; Borradaile, Kelley; Coyne, Michael; Denton, Carolyn A.; Dimino, Joseph; Furgeson, Joshua; Hayes, Lynda; Henke, Juliette; Justice, Laura; Keating, Betsy; Lewis, Warnick; Sattar, Samina; Streke, Andrei; Wagner, Richard; Wissel, Sarah

    2016-01-01

    The goal of this practice guide is to offer educators specific, evidence-based recommendations for teaching foundational reading skills to students in kindergarten through 3rd grade. This guide is a companion to the existing practice guide, "Improving Reading Comprehension in Kindergarten Through 3rd Grade", and as a set, these guides…

  4. Profit--The Key. Principles of the American Free Enterprise System for Distributive Education Students. Instructor's Guide.

    ERIC Educational Resources Information Center

    Hook, Sallie A.; And Others

    In this distributive education unit teacher's guide on the free enterprise system, principles of the American economic system are introduced as they relate to marketing and distribution. (The study guide is available as CE 020 458.) The guide preview sheet includes a list of audiovisual equipment necessary, duration of the unit (sixteen to…

  5. People, Animals and the Environment: An Educational Simulation Game. Teacher's Guide and Student Guide.

    ERIC Educational Resources Information Center

    American Animal Welfare Foundation, St. Paul, MN.

    This document consists of a teacher guide and a student guide to an educational simulation game that provides students with an opportunity to examine the relationship between humans and animals, and to explore the roles that animals play in daily life. The teaching technique employed is a student-centered process in which students work…

  6. Teachers' Guide for Aviation Education. For Use in Grades Two Through Six. Communication Arts, Science, Social Studies, Health, Career Education.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    This teacher's guide provides elementary teachers (grades 2-6) with supplementary learning activities centered around the subject of aviation, which may be used to enrich their regular programs. The guide is divided into the following five subject areas: communication arts, science, social studies, health, and careers in aviation. The guides vary…

  7. Algeria: A Study of the Educational System of Algeria and a Guide to the Academic Placement of Students in Educational Institutions of the United States.

    ERIC Educational Resources Information Center

    Mize, David W.

    Written as a guide to be used in the admission and placement of Algerian students in U.S. institutions of higher education, this study discusses the educational system of Algeria. The organization of Algerian education is summarized. Information is provided on preschool and primary education, middle school education, secondary education,…

  8. A time dependent mixing model to close PDF equations for transport in heterogeneous aquifers

    NASA Astrophysics Data System (ADS)

    Schüler, L.; Suciu, N.; Knabner, P.; Attinger, S.

    2016-10-01

    Probability density function (PDF) methods are a promising alternative to predicting the transport of solutes in groundwater under uncertainty. They make it possible to derive the evolution equations of the mean concentration and the concentration variance, used in moment methods. The mixing model, describing the transport of the PDF in concentration space, is essential for both methods. Finding a satisfactory mixing model is still an open question and due to the rather elaborate PDF methods, a difficult undertaking. Both the PDF equation and the concentration variance equation depend on the same mixing model. This connection is used to find and test an improved mixing model for the much easier to handle concentration variance. Subsequently, this mixing model is transferred to the PDF equation and tested. The newly proposed mixing model yields significantly improved results for both variance modelling and PDF modelling.

  9. Tooth Decay - Multiple Languages

    MedlinePlus

    ... Cantonese dialect)) PDF California Dental Association Early Childhood Caries - English PDF Early Childhood Caries - 繁體中文 (Chinese, Traditional (Cantonese dialect)) PDF California Dental ...

  10. Office of the Under Secretary of Defense (Comptroller)

    Science.gov Websites

    Estimates for FY 2019 (Green Book) PDF icon Excel icon (Zip File) Operations and Maintenance Overview Operation and Maintenance Overview PDF icon Budget Documents Military Personnel Programs (M-1) PDF icon Excel icon - Budget Appendix Display (M-1) Excel icon Operation and Maintenance Programs (O-1) PDF icon

  11. Publications - PDF 96-18 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 96-18 Publication Details Title: Major and trace element analyses of Cretaceous plutonic Bibliographic Reference Newberry, R.J., 1996, Major and trace element analyses of Cretaceous plutonic rocks in pdf1996_018.pdf (571.0 K) Keywords Geochemistry; Geology; Igneous Rocks; Major Oxides; Plutonic Rocks

  12. 32 CFR 117.53 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...,” (available at http://www.dtic.mil/whs/directives/corres/pdf/520507p.pdf). Classified contract. As defined in... Military and Associated Terms” (available at http://www.dtic.mil/doctrine/new_pubs/jp1_02.pdf). Company. As..., “Joint Communication System” (available at http://www.dtic.mil/doctrine/new_pubs/jp6_0.pdf). Contractor...

  13. Compressible cavitation with stochastic field method

    NASA Astrophysics Data System (ADS)

    Class, Andreas; Dumond, Julien

    2012-11-01

    Non-linear phenomena can often be well described using probability density functions (pdf) and pdf transport models. Traditionally the simulation of pdf transport requires Monte-Carlo codes based on Lagrange particles or prescribed pdf assumptions including binning techniques. Recently, in the field of combustion, a novel formulation called the stochastic field method solving pdf transport based on Euler fields has been proposed which eliminates the necessity to mix Euler and Lagrange techniques or prescribed pdf assumptions. In the present work, part of the PhD Design and analysis of a Passive Outflow Reducer relying on cavitation, a first application of the stochastic field method to multi-phase flow and in particular to cavitating flow is presented. The application considered is a nozzle subjected to high velocity flow so that sheet cavitation is observed near the nozzle surface in the divergent section. It is demonstrated that the stochastic field formulation captures the wide range of pdf shapes present at different locations. The method is compatible with finite-volume codes where all existing physical models available for Lagrange techniques, presumed pdf or binning methods can be easily extended to the stochastic field formulation.

  14. Guidelines for Planning Industrial Education Facilities and Equipment.

    ERIC Educational Resources Information Center

    Stallsmith, Douglas D.

    This guide presents alternatives, resources, and specifications for industrial education teachers to use in preparing a facilities proposal to present to administrators, boards of education, the community, and architects. Developed to reflect the objectives of industrial education as outlined in the "Wisconsin Guide to Local Curriculum…

  15. Guide to Microcomputer Courseware for Bilingual Education. Revised and Expanded.

    ERIC Educational Resources Information Center

    Sauve, Deborah, Comp.

    The guide to courseware for computer-assisted instruction and computer-managed instruction in bilingual education, English as a second language, and second language instruction contains entries from the National Clearinghouse for Bilingual Education's database and selected courseware for the related areas of special education, vocational…

  16. Pigment-Dispersing Factor-expressing neurons convey circadian information in the honey bee brain

    PubMed Central

    Beer, Katharina; Kolbe, Esther; Kahana, Noa B.; Yayon, Nadav; Weiss, Ron; Menegazzi, Pamela; Bloch, Guy

    2018-01-01

    Pigment-Dispersing Factor (PDF) is an important neuropeptide in the brain circadian network of Drosophila and other insects, but its role in bees in which the circadian clock influences complex behaviour is not well understood. We combined high-resolution neuroanatomical characterizations, quantification of PDF levels over the day and brain injections of synthetic PDF peptide to study the role of PDF in the honey bee Apis mellifera. We show that PDF co-localizes with the clock protein Period (PER) in a cluster of laterally located neurons and that the widespread arborizations of these PER/PDF neurons are in close vicinity to other PER-positive cells (neurons and glia). PDF-immunostaining intensity oscillates in a diurnal and circadian manner with possible influences for age or worker task on synchrony of oscillations in different brain areas. Finally, PDF injection into the area between optic lobes and the central brain at the end of the subjective day produced a consistent trend of phase-delayed circadian rhythms in locomotor activity. Altogether, these results are consistent with the hypothesis that PDF is a neuromodulator that conveys circadian information from pacemaker cells to brain centres involved in diverse functions including locomotion, time memory and sun-compass orientation. PMID:29321240

  17. Buffer-dependent regulation of aquaporin-1 expression and function in human peritoneal mesothelial cells.

    PubMed

    Zhai, Yihui; Bloch, Jacek; Hömme, Meike; Schaefer, Julia; Hackert, Thilo; Philippin, Bärbel; Schwenger, Vedat; Schaefer, Franz; Schmitt, Claus P

    2012-07-01

    Biocompatible peritoneal dialysis fluids (PDF) are buffered with lactate and/or bicarbonate. We hypothesized that the reduced toxicity of the biocompatible solutions might unmask specific effects of the buffer type on mesothelial cell functions. Human peritoneal mesothelial cells (HPMC) were incubated with bicarbonate (B-)PDF or lactate-buffered (L-)PDF followed by messenger RNA (mRNA) and protein analysis. Gene silencing was achieved using small interfering RNA (siRNA), functional studies using Transwell culture systems, and monolayer wound-healing assays. Incubation with B-PDF increased HPMC migration in the Transwell and monolayer wound-healing assay to 245 ± 99 and 137 ± 11% compared with L-PDF. Gene silencing showed this effect to be entirely dependent on the expression of aquaporin-1 (AQP-1) and independent of AQP-3. Exposure of HPMC to B-PDF increased AQP-1 mRNA and protein abundance to 209  ± 80 and 197  ±  60% of medium control; the effect was pH dependent. L-PDF reduced AQP-1 mRNA. Addition of bicarbonate to L-PDF increased AQP-1 abundance by threefold; mRNA half-life remained unchanged. Immunocytochemistry confirmed opposite changes of AQP-1 cell-membrane abundance with B-PDF and L-PDF. Peritoneal mesothelial AQP-1 abundance and migration capacity is regulated by pH and buffer agents used in PD solutions. In vivo studies are required to delineate the impact with respect to long-term peritoneal membrane integrity and function.

  18. A circadian neuropeptide PDF in the honeybee, Apis mellifera: cDNA cloning and expression of mRNA.

    PubMed

    Sumiyoshi, Miho; Sato, Seiji; Takeda, Yukimasa; Sumida, Kazunori; Koga, Keita; Itoh, Tsunao; Nakagawa, Hiroyuki; Shimohigashi, Yasuyuki; Shimohigashi, Miki

    2011-12-01

    Pigment-dispersing factor (PDF) is a pacemaker hormone regulating the locomotor rhythm in insects. In the present study, we cloned the cDNAs encoding the Apis PDF precursor protein, and found that there are at least seven different pdf mRNAs yielded by an alternative splicing site and five alternative polyadenylation sites in the 5'UTR and 3'UTR regions. The amino acid sequence of Apis PDF peptide has a characteristic novel amino acid residue, aspargine (Asn), at position 17. Quantitative real-time PCR of total and 5'UTR insertion-type pdf mRNAs revealed, for the first time, that the expression levels change in a circadian manner with a distinct trough at the beginning of night in LD conditions, and at the subjective night under DD conditions. In contrast, the expression level of 5'UTR deletion-type pdf mRNAs was about half of that of the insertion type, and the expression profile failed to show a circadian rhythm. As the expression profile of the total pdf mRNA exhibited a circadian rhythm, transcription regulated at the promoter region was supposed to be controlled by some of the clock components. Whole mount in situ hybridization revealed that 14 lateral neurons at the frontal margin of the optic lobe express these mRNA isoforms. PDF expressing cells examined with a newly produced antibody raised against Apis PDF were also found to have a dense supply of axon terminals in the optic lobes and the central brain.

  19. Peptide Deformylase Inhibitors as Potent Antimycobacterial Agents▿ †

    PubMed Central

    Teo, Jeanette W. P.; Thayalan, Pamela; Beer, David; Yap, Amelia S. L.; Nanjundappa, Mahesh; Ngew, Xinyi; Duraiswamy, Jeyaraj; Liung, Sarah; Dartois, Veronique; Schreiber, Mark; Hasan, Samiul ; Cynamon, Michael; Ryder, Neil S.; Yang, Xia; Weidmann, Beat; Bracken, Kathryn ; Dick, Thomas; Mukherjee, Kakoli

    2006-01-01

    Peptide deformylase (PDF) catalyzes the hydrolytic removal of the N-terminal formyl group from nascent proteins. This is an essential step in bacterial protein synthesis, making PDF an attractive target for antibacterial drug development. Essentiality of the def gene, encoding PDF from Mycobacterium tuberculosis, was demonstrated through genetic knockout experiments with Mycobacterium bovis BCG. PDF from M. tuberculosis strain H37Rv was cloned, expressed, and purified as an N-terminal histidine-tagged recombinant protein in Escherichia coli. A novel class of PDF inhibitors (PDF-I), the N-alkyl urea hydroxamic acids, were synthesized and evaluated for their activities against the M. tuberculosis PDF enzyme as well as their antimycobacterial effects. Several compounds from the new class had 50% inhibitory concentration (IC50) values of <100 nM. Some of the PDF-I displayed antibacterial activity against M. tuberculosis, including MDR strains with MIC90 values of <1 μM. Pharmacokinetic studies of potential leads showed that the compounds were orally bioavailable. Spontaneous resistance towards these inhibitors arose at a frequency of ≤5 × 10−7 in M. bovis BCG. DNA sequence analysis of several spontaneous PDF-I-resistant mutants revealed that half of the mutants had acquired point mutations in their formyl methyltransferase gene (fmt), which formylated Met-tRNA. The results from this study validate M. tuberculosis PDF as a drug target and suggest that this class of compounds have the potential to be developed as novel antimycobacterial agents. PMID:16966397

  20. Effects of a new bicarbonate/lactate-buffered neutral peritoneal dialysis fluid for peritoneal failure in patients undergoing peritoneal dialysis.

    PubMed

    Hoshino, Taro; Ishii, Hiroki; Kitano, Taisuke; Shindo, Mitsutoshi; Miyazawa, Haruhisa; Yamada, Hodaka; Ito, Kiyonori; Ueda, Yuichiro; Kaku, Yoshio; Hirai, Keiji; Mori, Honami; Ookawara, Susumu; Tabei, Kaoru; Morishita, Yoshiyuki

    2016-02-01

    The highly concentrated lactate in peritoneal dialysis fluid (PDF) has been considered to contribute to peritoneal failure in patients undergoing PD. A new PDF containing a lower lactate concentration, physiological bicarbonate concentration, and neutral pH (bicarbonate/lactate-buffered neutral PDF) was recently developed. We compared the clinical effects of this bicarbonate/lactate-buffered neutral PDF and a lactate-buffered neutral PDF. Patients undergoing PD were changed from a lactate-buffered neutral PDF to a bicarbonate/lactate-buffered neutral PDF. We then investigated the changes in peritoneal functions as estimated by a peritoneal equilibration test (PET) and the following surrogate markers of peritoneal membrane failure in the drained dialysate: fibrin degradation products (FDP), vascular endothelial growth factor (VEGF), cancer antigen 125 (CA125), interleukin-6 (IL-6), and transforming growth factor beta 1 (TGF-β1). Fourteen patients undergoing PD were enrolled. The PET results were not different before and after use of the bicarbonate/lactate-buffered neutral PDF. The FDP concentration significantly decreased from 15.60 ± 13.90 to 6.04 ± 3.49 μg/mL (p = 0.02) and the VEGF concentration significantly decreased from 37.83 ± 15.82 to 27.70 ± 3.80 pg/mL (p = 0.02), while the CA125 and IL-6 concentrations remained unchanged before and after use of the bicarbonate/lactate-buffered neutral PDF. TGF-β1 was not detected in most patients. The bicarbonate/lactate-buffered neutral PDF decreased the FDP and VEGF concentrations in the drained dialysate. These results suggest that the decreased lactate level achieved by administration of bicarbonate with a neutral pH in PDF may contribute to decreased peritoneal membrane failure in patients undergoing PD.

  1. Alanyl-glutamine dipeptide restores the cytoprotective stress proteome of mesothelial cells exposed to peritoneal dialysis fluids.

    PubMed

    Kratochwill, Klaus; Boehm, Michael; Herzog, Rebecca; Lichtenauer, Anton Michael; Salzer, Elisabeth; Lechner, Michael; Kuster, Lilian; Bergmeister, Konstantin; Rizzi, Andreas; Mayer, Bernd; Aufricht, Christoph

    2012-03-01

    Exposure of mesothelial cells to peritoneal dialysis fluids (PDF) results in cytoprotective cellular stress responses (CSR) that counteract PDF-induced damage. In this study, we tested the hypothesis that the CSR may be inadequate in relevant models of peritoneal dialysis (PD) due to insufficient levels of glutamine, resulting in increased vulnerability against PDF cytotoxicity. We particularly investigated the role of alanyl-glutamine (Ala-Gln) dipeptide on the cytoprotective PDF stress proteome. Adequacy of CSR was investigated in two human in vitro models (immortalized cell line MeT-5A and mesothelial cells derived from peritoneal effluent of uraemic patients) following exposure to heat-sterilized glucose-based PDF (PD4-Dianeal, Baxter) diluted with medium and, in a comparative proteomics approach, at different levels of glutamine ranging from depletion (0 mM) via physiological (0.7 mM) to pharmacological levels (8 mM administered as Ala-Gln). Despite severe cellular injury, expression of cytoprotective proteins was dampened upon PDF exposure at physiological glutamine levels, indicating an inadequate CSR. Depletion of glutamine aggravated cell injury and further reduced the CSR, whereas addition of Ala-Gln at pharmacological level restored an adequate CSR, decreasing cellular damage in both PDF exposure systems. Ala-Gln specifically stimulated chaperoning activity, and cytoprotective processes were markedly enhanced in the PDF stress proteome. Taken together, this study demonstrates an inadequate CSR of mesothelial cells following PDF exposure associated with low and physiological levels of glutamine, indicating a new and potentially relevant pathomechanism. Supplementation of PDF with pharmacological doses of Ala-Gln restored the cytoprotective stress proteome, resulting in improved resistance of mesothelial cells to exposure to PDF. Future work will study the clinical relevance of CSR-mediated cytoprotection.

  2. Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: immunocytochemical evidence from specific monoclonal antibodies.

    PubMed

    Honda, Takeshi; Matsushima, Ayami; Sumida, Kazunori; Chuman, Yoshiro; Sakaguchi, Kazuyasu; Onoue, Hitoshi; Meinertzhagen, Ian A; Shimohigashi, Yasuyuki; Shimohigashi, Miki

    2006-11-20

    Pigment-dispersing factor (PDF) is an 18-mer peptide that acts as a principal neurotransmitter of the insect circadian clock. Our previous study, utilizing anti-Uca beta-PDH polyclonal antibody (pAb) to immunolabel the optic lobe of the cricket Gryllus bimaculatus, suggested the existence of an alternative PDF-like peptide in the outer cells of the first neuropile, or lamina (La), which were much less immunoreactive than the inner cells of the second neuropile, the medulla (Me). To obtain structural information about such a PDF-like peptide, we prepared 10 anti-Gryllus PDF monoclonal (mAb) and pAb antibodies and analyzed their detailed epitope specificities. The PDFMe and PDFLa inner cells and their axonal projections were clearly immunoreactive to all these antibodies, revealing the widespread immunocytochemical organization of the PDF system in the optic lobe, as seen previously with anti-Uca beta-PDH pAb and anti-Gryllus PDF mAb, the epitope structures of which were also clarified in this study. The lamina outer cells, which we found lacked a target pdf mRNA, displayed specific immunoreactivities, indicating that the cells contain a distinct PDF-like peptide possessing both N- and C-terminal structures. These cells were not immunolabeled by some other monoclonal antibodies, however, implying that the PDFLa outer cells have a PDF isoform peptide devoid of Asn at positions 6 and 16. This isoform was also identified in a varicose arborization in the lamina. These results suggest not only the structure of the peptide, but also the possibility of additional functions of this novel PDF isoform.

  3. Application and Evaluation of Interactive 3D PDF for Presenting and Sharing Planning Results for Liver Surgery in Clinical Routine

    PubMed Central

    Newe, Axel; Becker, Linda; Schenk, Andrea

    2014-01-01

    Background & Objectives The Portable Document Format (PDF) is the de-facto standard for the exchange of electronic documents. It is platform-independent, suitable for the exchange of medical data, and allows for the embedding of three-dimensional (3D) surface mesh models. In this article, we present the first clinical routine application of interactive 3D surface mesh models which have been integrated into PDF files for the presentation and the exchange of Computer Assisted Surgery Planning (CASP) results in liver surgery. We aimed to prove the feasibility of applying 3D PDF in medical reporting and investigated the user experience with this new technology. Methods We developed an interactive 3D PDF report document format and implemented a software tool to create these reports automatically. After more than 1000 liver CASP cases that have been reported in clinical routine using our 3D PDF report, an international user survey was carried out online to evaluate the user experience. Results Our solution enables the user to interactively explore the anatomical configuration and to have different analyses and various resection proposals displayed within a 3D PDF document covering only a single page that acts more like a software application than like a typical PDF file (“PDF App”). The new 3D PDF report offers many advantages over the previous solutions. According to the results of the online survey, the users have assessed the pragmatic quality (functionality, usability, perspicuity, efficiency) as well as the hedonic quality (attractiveness, novelty) very positively. Conclusion The usage of 3D PDF for reporting and sharing CASP results is feasible and well accepted by the target audience. Using interactive PDF with embedded 3D models is an enabler for presenting and exchanging complex medical information in an easy and platform-independent way. Medical staff as well as patients can benefit from the possibilities provided by 3D PDF. Our results open the door for a wider use of this new technology, since the basic idea can and should be applied for many medical disciplines and use cases. PMID:25551375

  4. Application and evaluation of interactive 3D PDF for presenting and sharing planning results for liver surgery in clinical routine.

    PubMed

    Newe, Axel; Becker, Linda; Schenk, Andrea

    2014-01-01

    The Portable Document Format (PDF) is the de-facto standard for the exchange of electronic documents. It is platform-independent, suitable for the exchange of medical data, and allows for the embedding of three-dimensional (3D) surface mesh models. In this article, we present the first clinical routine application of interactive 3D surface mesh models which have been integrated into PDF files for the presentation and the exchange of Computer Assisted Surgery Planning (CASP) results in liver surgery. We aimed to prove the feasibility of applying 3D PDF in medical reporting and investigated the user experience with this new technology. We developed an interactive 3D PDF report document format and implemented a software tool to create these reports automatically. After more than 1000 liver CASP cases that have been reported in clinical routine using our 3D PDF report, an international user survey was carried out online to evaluate the user experience. Our solution enables the user to interactively explore the anatomical configuration and to have different analyses and various resection proposals displayed within a 3D PDF document covering only a single page that acts more like a software application than like a typical PDF file ("PDF App"). The new 3D PDF report offers many advantages over the previous solutions. According to the results of the online survey, the users have assessed the pragmatic quality (functionality, usability, perspicuity, efficiency) as well as the hedonic quality (attractiveness, novelty) very positively. The usage of 3D PDF for reporting and sharing CASP results is feasible and well accepted by the target audience. Using interactive PDF with embedded 3D models is an enabler for presenting and exchanging complex medical information in an easy and platform-independent way. Medical staff as well as patients can benefit from the possibilities provided by 3D PDF. Our results open the door for a wider use of this new technology, since the basic idea can and should be applied for many medical disciplines and use cases.

  5. Idaho Driver Education Administrative Guide.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise.

    This guide provides information for school administrators and directors of commercial driver training schools about conducting driver education courses in Idaho. The first part of the guide, which applies to both public schools and commercial schools, covers the following areas: administration, sample letters and forms, instructional time…

  6. Resource Guide to Competency-Based Vocational Education: Health Occupations.

    ERIC Educational Resources Information Center

    Foster, Phillip R., Comp.

    This resource guide for classroom teachers contains annotations of resources representing recent instructional development in competency-based education for health occupations. It is also intended to assist curriculum specialists, administrators, and supervisors in development of performance-based instructional programs. The guide is divided into…

  7. VizieR Online Data Catalog: Example of FERRE code spectra (Aguado+, 2017)

    NASA Astrophysics Data System (ADS)

    Aguado, D. S.; Gonzalez Hernandez, J. I.; Allende Prieto, C.; Rebolo, R.

    2017-05-01

    FERRE matches physical models to observed data. It was created to deal with the common problem of having numerical models that are costly to evaluate, and need to be used to interpret large data sets. ferre.pdf file contains the FERRE uses's guide. The code can be obtained from http://hebe.as.utexas.edu/ferre Example : f_crump3h.dat is a tool usable with FERRE with the parameters shown in its header: Resolving Power:10.000 3600 <= λ <= 9000Å, -6 <= [Fe/H] <=-2, -1 <= [C/Fe] <= 5, 4750 <= Tefff <= 7000, 1.0 <= logg <= 5.0, It is the grid used for the paper. (2 data files).

  8. Teaching diversity to medical undergraduates: Curriculum development, delivery and assessment. AMEE GUIDE No. 103.

    PubMed

    Dogra, Nisha; Bhatti, Farah; Ertubey, Candan; Kelly, Moira; Rowlands, Angela; Singh, Davinder; Turner, Margot

    2016-01-01

    The aim of this Guide is to support teacher with the responsibility of designing, delivering and/or assessing diversity education. Although, the focus is on medical education, the guidance is relevant to all healthcare professionals. The Guide begins by providing an overview of the definitions used and the principles that underpin the teaching of diversity as advocated by Diversity and Medicine in Health (DIMAH). Following an outline of these principles we highlight the difference between equality and diversity education. The Guide then covers diversity education throughout the educational process from the philosophical stance of educators and how this influences the approaches used through to curriculum development, delivery and assessment. Appendices contain practical examples from across the UK, covering lesson plans and specific exercises to deliver teaching. Although, diversity education remains variable and fragmented there is now some momentum to ensure that the principles of good educational practice are applied to diversity education. The nature of this topic means that there are a range of different professions and medical disciplines involved which leads to a great necessity for greater collaboration and sharing of effective practice.

  9. The Ways of the Watersheds: An Educator's Guide to the Environmental and Cultural Dynamics of New York City's Water Supplies.

    ERIC Educational Resources Information Center

    Haskin, Kathleen M.

    A watershed is an area of land where water is drained ultimately to a particular watercourse or body of water. This curriculum guide acts as a comprehensive resource for educators at all levels to explore the many facets of watersheds for New York City. The guide investigates all the dynamics of watershed education, exploring the environmental and…

  10. A Quick and Handy Guide to Educational Mentoring. A Product of a 310 Special Demonstration Training Project 1982-83, "Training Mentors as Educational Counselors of Adult Learners."

    ERIC Educational Resources Information Center

    Singer, Elizabeth

    Developed in two training sessions involving key personnel from business, industry, and community agencies who counsel employees or clients about career changes, this handbook is intended to help persons who are responsible for guiding adults through educational or career changes. The guide is organized into 11 sections. Topics covered by these…

  11. Energy Use and the Environment. Concepts & Activities for the Classroom: Mathematics Module. Environmental Education Supplementary Instructional Guide.

    ERIC Educational Resources Information Center

    Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

    As part of a comprehensive, interdisciplinary environmental education program for elementary and secondary education in Hawaii, this teaching guide provides a variety of energy education activities for secondary school mathematics. An extensive introduction outlines the total program and how it fits into the general education program and explains…

  12. Honorable Intentions: A Parent's Guide to Educational Planning for Children with Emotional or Behavioral Disorders. Second Edition.

    ERIC Educational Resources Information Center

    Jordan, Dixie; Goldberg, Paula

    This guide to help parents work in collaboration with the school team to enhance the education of their children with emotional or behavioral disorders considers special education and related services, special education evaluation, the Individualized Education Program (IEP), school rules and policies, day treatment, residential placement,…

  13. Children and Chess: A Guide for Educators

    ERIC Educational Resources Information Center

    Root, Alexey

    2006-01-01

    "Children and Chess: A Guide for Educators" is the first book to show the connection between accepted educational theories and chess. The relationship of chess to academic and humanistic educational goals is convincingly illustrated as curriculum and psychological theories from John D. McNeil, Mihaly Csikszentmihalyi, and Howard Gardner are…

  14. Educational Specifications: Linking Design of School Facilities to Educational Program.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Div. of School Facilities Planning.

    The California Department of Education, directed to formalize regulations governing standards for new school design and construction, has prepared a guide to help school districts develop specifications based on the architectural principle that form follows function. This guide discusses the meaning of educational specifications and their…

  15. Resources on Civic Education for Democracy: International Perspectives. Yearbook No. 2.

    ERIC Educational Resources Information Center

    Pinhey, Laura A., Ed.; Boyer, Candace L., Ed.

    This resource guide is intended to facilitate cooperation and exchange of knowledge among civic educators around the world. The guide is divided into six parts. Part 1 consists of three civic education papers: "Education and Democratic Citizenship: Where We Stand" (Albert Shanker); "Civil Society and Democracy Reconsidered"…

  16. Higher Education Finance Manual: Volume 2. Data Users' Guide.

    ERIC Educational Resources Information Center

    Collier, Douglas J.; Allen, Richard H.

    The second volume of the revised "Higher Education Finance Manual" (HEFM), this data users' guide is oriented to the nonaccountant and describes the kinds of information about postsecondary education that can be derived from institutional financial data. Contents include: a description of fund accounting for higher education, a…

  17. Professional Development Guide for Educators. The Multicultural Resource Series, Volume 1.

    ERIC Educational Resources Information Center

    Gorski, Paul, Ed.; Shin, Gene-Tey, Ed.; Green, Martha, Ed.

    This guide presents a collection of personal essays written by educators who describe how multicultural education has transformed their teaching. It also includes resources such as multicultural organizations, publications, videos, and Web sites. Chapter 1, "Multicultural Education: Voices and Visions," includes "Ethiopia at the Bar…

  18. Legal Secretarial Supplement to the California Business Education Program Guide.

    ERIC Educational Resources Information Center

    Holst, Alice L.; And Others

    This supplement to the California Business Education Program Guide for Office and Distributive Occupations is designed to assist office education teachers of secondary, postsecondary, and adult students to update their business education curricula in light of new technology and increasing demand for skilled office workers. Focusing on the legal…

  19. Curriculum Guide for Health Occupations Education. Revised and Expanded.

    ERIC Educational Resources Information Center

    Oyler, Charles; Swinney, Peggy

    Designed to emphasize the acquisition of job skills, job-practical knowledge, job-theoretical knowledge, and associative needs, this curriculum guide for health occupations education utilizes principles of competency-based education and is reflective of a training model approach to health occupations education. The first of three major parts…

  20. Guide for Teaching Physical Education, Grades 7-12.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    GRADES OR AGES: Grades 7-12. SUBJECT MATTER: Physical education, including team sports, stunts, tumbling and gymnastics, track and field, swimming, individual and dual sports, physical education for the handicapped, outdoor education, and rhythmic activities. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into 16 chapters, each of…

  1. Scout and Guides, Key Users of Astronomy & Planetary Sciences Outreach that Support Education

    NASA Astrophysics Data System (ADS)

    Brumfitt, A.; Thompson, L.

    Few people outside of the Scouting and Guide movement would appreciate that these world wide organisations have an active youth membership of over 40 million children and young adults. These two organisations rely on external specialist expert knowledge for the effective delivery of their education and award schemes. The high membership and established program delivery pathways make these organisations excellent vehicles for outreach programs. In particular Scouts and Guides are able to introduce astronomy and planetary sciences into their informal education programs at a timing that best suits the child and not one constrained by the schedule of formal education. It is the global voluntary nature of membership of these organisations that make them extremely effective learning vehicles. The members both youth and leader are highly motivated. These two organisations have a structured education program for youth members based on both individual pursuits or targets and group projects. The organisations has as part of their infra structure benchmarks for the measure of excellence in achievement and education at all levels. Scouts and Guides are a way of encompassing knowledge and lighting candles for life long learning. Scouts and guides address all year groups of formal education from primary through to tertiary levels, from cubs and brownies through various levels to Rovers and Rangers. Space is seen as relevant to Scouting and Guides, the Guide movement UK has recently adopted a "Go for it" challenge award for youth members to investigate space science. Similar awards exist in the Scouting movement in Europe, USA and Australia. The ready adoption of Space science fits well with scouting principles as Space is perceived as the "New Frontier of Discovery". In October 2007, Scouts and Guides from Europe will gather at Tidbinbilla deep space Tracking Station, Australia for the first Scout and Guide International Space Camp. The model used for this camp was based on a pilot camp in Australia of 1200 participants which used the Tracking Station, Astronomy Groups and the Mt Stromlo Observatory and its astronomers, Science Centres and Universities as key tools in the program design and delivery. The enormous sizes and the excellent formalised organisational structure of Scouts and Guides makes these organisations excellent vehicles for the development of space education programs that can be then transferred to traditional formal education organisations such as schools. This paper discusses mechanisms for effective engagement by astronomy planetaria science groups through Scouts and guides to kids.

  2. Learning From Our Past: How a Vietnam-Era Pacification Program Can Help Us Win in Afghanistan

    DTIC Science & Technology

    2009-09-01

    Economies, March 26, 2004), http://www.uib.es/depart/deaweb/ smed /pdf/collier.pdf (accessed August 25, 2009). 34 Nicole J. Ball, “Strengthening Democratic...Challenge Paper. Centre for the Study of African Economies, March 26, 2004, http://www.uib.es/depart/deaweb/ smed /pdf/collier.pdf (accessed August 25, 2009

  3. An easy and effective approach to manage radiologic portable document format (PDF) files using iTunes.

    PubMed

    Qian, Li Jun; Zhou, Mi; Xu, Jian Rong

    2008-07-01

    The objective of this article is to explain an easy and effective approach for managing radiologic files in portable document format (PDF) using iTunes. PDF files are widely used as a standard file format for electronic publications as well as for medical online documents. Unfortunately, there is a lack of powerful software to manage numerous PDF documents. In this article, we explain how to use the hidden function of iTunes (Apple Computer) to manage PDF documents as easily as managing music files.

  4. Teaching medical students ultrasound-guided vascular access - which learning method is best?

    PubMed

    Lian, Alwin; Rippey, James C R; Carr, Peter J

    2017-05-15

    Ultrasound is recommended to guide insertion of peripheral intravenous vascular cannulae (PIVC) where difficulty is experienced. Ultrasound machines are now common-place and junior doctors are often expected to be able to use them. The educational standards for this skill are highly varied, ranging from no education, to self-guided internet-based education, to formal, face-to-face traditional education. In an attempt to decide which educational technique our institution should introduce, a small pilot trial comparing educational techniques was designed. Thirty medical students were enrolled and allocated to one of three groups. PIVC placing ability was then observed, tested and graded on vascular access phantoms. The formal, face-to-face traditional education was rated best by the students, and had the highest success rate in PIVC placement, the improvement statistically significant compared to no education (p = 0.01) and trending towards significance when compared to self-directed internet-based education (p<0.06). The group receiving traditional face-to-face teaching on ultrasound-guided vascular access, performed significantly better than those not receiving education. As the number of ultrasound machines in clinical areas increases, it is important that education programs to support their safe and appropriate use are developed.

  5. Guide to the Evaluation of Educational Experiences in the Armed Services. The 1978 Guide. 1: Air Force.

    ERIC Educational Resources Information Center

    American Council on Education, Washington, DC. Office on Educational Credit.

    Postsecondary educational credit recommendations for formal courses offered by the Air Force and the Department of Defense are provided in this first of a three-volume guide. (Other volumes cover courses offered by the Army and by the Coast Guard, Marine Corps, and Navy. See note.) Following brief sections on use of the guide, the formal course…

  6. Federal Aviation Administration Aviation Education Teacher's Guide, [Grades] 4-6.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    This guide is one in a series of four resource guides specifically designed for those interested in aviation education. Activities and lessons that can be used in a variety of content areas and grade levels are featured. Grades 4-6 are the focus of this guide, which is organized under the broad topics of properties of air, lighter than air flight,…

  7. On Being a Master Planner - A Step by Step Guide. From a Nationwide Study of Environmental Education Planning.

    ERIC Educational Resources Information Center

    Rocchio, Richard; Lee, Eve

    This guide demonstrates a new way of utilizing the planning process within a social movement context in view of developing a state master plan for environmental education. In addition the book serves as a guide to realistic planning, including models, definitions, and examples. The guide contains five parts: Part One - The background, Part Two -…

  8. Professional Learning Communities Facilitator's Guide for the What Works Clearinghouse Practice Guide: Foundational Skills to Support Reading for Understanding in Kindergarten through 3rd Grade. REL 2016-277

    ERIC Educational Resources Information Center

    Kosanovich, Marcia; Foorman, Barbara

    2016-01-01

    The Regional Educational Laboratory (REL) Southeast developed a Professional Learning Community (PLC) Facilitators Guide to support educators in the implementation of recommendations from the What Works Clearinghouse's. The practice guide focuses on the foundational reading skills that enable students to read words, relate those words to their…

  9. Telecommunication Networks. Tech Use Guide: Using Computer Technology.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Center for Special Education Technology.

    One of nine brief guides for special educators on using computer technology, this guide focuses on utilizing the telecommunications capabilities of computers. Network capabilities including electronic mail, bulletin boards, and access to distant databases are briefly explained. Networks useful to the educator, general commercial systems, and local…

  10. Curriculum Guide for Marketing.

    ERIC Educational Resources Information Center

    Oregon State Board of Education, Salem. Div. of Community Colleges and Career Education.

    Oregon is embarking on a new approach to secondary education, and this marketing curriculum guide was prepared to assist curriculum specialists in developing high school, entry-level employment programs. Developed in consultation with representatives of industry and education, the guide makes extensive use of the cluster concept, manpower data,…

  11. Personal Finance Education Guide.

    ERIC Educational Resources Information Center

    Oregon State Board of Education, Salem.

    The guide was developed to aid teachers in planning and developing programs in personal finance education which will prepare students to function as intelligent consumers. Three case studies illustrating common consumer problems are followed by the body of the guide, focusing on five major topics and incorporating economic, social, and physical…

  12. Aviation & Space Education: A Teacher's Resource Guide.

    ERIC Educational Resources Information Center

    Texas State Dept. of Aviation, Austin.

    This resource guide contains information on curriculum guides, resources for teachers, computer software and computer related programs, audio/visual presentations, model aircraft and demonstration aids, training seminars and career education, and an aerospace bibliography for primary grades. Each entry includes all or some of the following items:…

  13. Educational Resource Guide for Adapted Physical Education.

    ERIC Educational Resources Information Center

    Ciccaglione, Sue; Magliaro, Susan

    The guide is intended to provide information to adapted physical education instructors. An initial section introduces characteristics of the following handicapping conditions: autism, diabetes, emotional disturbance, learning disabilities, mental retardation, musculoskeletal disorders, neuromuscular disorders, seizure and convulsive disorders, and…

  14. Pain Relievers - Multiple Languages

    MedlinePlus

    ... español (Spanish) Bilingual PDF Health Information Translations Fentanyl - Opioid addiction, part 6 - English PDF Fentanyl - Opioid addiction, part 6 - español (Spanish) PDF Fentanyl - Opioid addiction, ...

  15. FAA Air Transportation Modernization and Safety Improvement Act

    THOMAS, 111th Congress

    Rep. Rangel, Charles B. [D-NY-15

    2009-03-18

    08/10/2010 Became Public Law No: 111-226. (TXT | PDF) (All Actions) Notes: As enacted, the bill funds education jobs and Medicaid, but in a previous version funded aviation programs. The title shown at the top of the page is that of the last version of the bill that contained a title. Tracker: This bill has the status Became LawHere are the steps for Status of Legislation:

  16. The Infusion of Language, Regional, and Cultural Content into Military Education: Status Report

    DTIC Science & Technology

    2011-01-01

    outreach (to, for example, partner militaries) with typically only limited U.S. Government representation. Findings Throughout DoD, tremendous effort...U.S. Government Printing Office, Washington, 1989 http://www.au.af.mil/au/awc/awcgate/congress/skelton1989/skelton.pdf 4 29 January 2010 TASK ORDER...are: Application of combat power (military art and science), Culture and foreign language, an understanding of Governance , an understanding of

  17. Una Guia para Los Padres sobre La Educacion Especial: El Derecho de Su Hijo(a) a Adquirir una Educacion en el Estado de Nueva York (A Parent's Guide to Special Education: Your Child's Right to an Education in New York State).

    ERIC Educational Resources Information Center

    New York State Education Dept. Albany. Office for the Education of Children with Handicapping Conditions.

    This guide provides information to help parents of special needs children in New York become active partners in the planning and implementation of special education programs. The first part of the guide provides in-depth information related to the special education process in New York State public schools. A historical view of children's rights to…

  18. Border Environmental Education Resource Guide: Southern New Mexico, South Texas, Northern Chihuahua, Northern Coahuila, Northern Nuevo Leon, Northern Tamaulipas = Guia de Recursos de Educacion Ambiental en la Frontera: Sur de Nuevo Mexico, Sur de Texas, Norte de Chihuahua, Norte de Coahuila, Norte de Nuevo Leon, Norte de Tamaulipas.

    ERIC Educational Resources Information Center

    Meissner, David, Comp.

    This guide provides educators and residents of the border with useful information about environmental education program offerings along the eastern half of the United States-Mexico border. The programs listed in the guide represent a broad range of educational efforts focused on understanding the environment and solving environmental problems in…

  19. Development of the "Recovery from Eating Disorders for Life" Food Guide (REAL Food Guide) - a food pyramid for adults with an eating disorder.

    PubMed

    Hart, Susan; Marnane, Claire; McMaster, Caitlin; Thomas, Angela

    2018-01-01

    There is limited evidence to inform nutrition and dietetic interventions for individuals with eating disorders even though it is recommended as an essential part of multidisciplinary management. There is minimal guidance, an absence of standardised nutrition educational material, and no research on how best to educate patients on healthy eating and how to achieve nutrition adequacy. Therefore the REAL Food Guide was developed. The REAL Food Guide is a pyramid with four layers and key nutrition messages beside each layer that was conceived to address gaps in nutrition education and intervention for individuals with eating disorders. Written and verbal consumer feedback was obtained from consumers receiving treatment regarding the acceptability and usefulness of the REAL Food Guide. A unique database was developed to reflect the types of foods and realistic portion sizes that patients are likely to select. This database was used for nutrition modelling to assess the nutrition adequacy of three meal patterns (meat containing, vegetarian and semi-vegan) for both weight maintenance and weight regain. Each meal pattern was compared to the Nutrient Reference Values for Australia and New Zealand. Nutritional analysis demonstrated nutritional adequacy of meal patterns for energy, macronutrients and most micronutrients when the recommended number of serves from the REAL Food Guide were assessed. All meal patterns were adequate in micronutrients except for the semi-vegan meal pattern that was inadequate in vitamin D. Feedback from individuals with eating disorders demonstrates the nutrition education tool was acceptable to them as they felt it was more helpful for their recovery than general nutrition guidelines. The REAL Food Guide is a comprehensive and user-friendly guide that clinicians can use to educate patients about components of a balanced and healthy diet. The guide can educate all eating disorder clinicians, including those who are new to the field, about the basics of nutrition. Clinicians using the guide can be confident that, if followed, patient's energy and nutritional requirements will be met and important nutrition education messages are reinforced, that are tailored to the beliefs and concerns of individuals with eating disorders.

  20. Impacts of icodextrin on integrin-mediated wound healing of peritoneal mesothelial cells.

    PubMed

    Matsumoto, Mika; Tamura, Masahito; Miyamoto, Tetsu; Furuno, Yumi; Kabashima, Narutoshi; Serino, Ryota; Shibata, Tatsuya; Kanegae, Kaori; Takeuchi, Masaaki; Abe, Haruhiko; Okazaki, Masahiro; Otsuji, Yutaka

    2012-06-14

    Exposure to glucose and its metabolites in peritoneal dialysis fluid (PDF) results in structural alterations of the peritoneal membrane. Icodextrin-containing PDF eliminates glucose and reduces deterioration of peritoneal membrane function, but direct effects of icodextrin molecules on peritoneal mesothelial cells have yet to be elucidated. We compared the impacts of icodextrin itself with those of glucose under PDF-free conditions on wound healing processes of injured mesothelial cell monolayers, focusing on integrin-mediated cell adhesion mechanisms. Regeneration processes of the peritoneal mesothelial cell monolayer were investigated employing an in vitro wound healing assay of cultured rat peritoneal mesothelial cells treated with icodextrin powder- or glucose-dissolved culture medium without PDF, as well as icodextrin- or glucose-containing PDF. The effects of icodextrin on integrin-mediated cell adhesions were examined by immunocytochemistry and Western blotting against focal adhesion kinase (FAK). Cell migration over fibronectin was inhibited in conventional glucose-containing PDF, while icodextrin-containing PDF exerted no significant inhibitory effects. Culture medium containing 1.5% glucose without PDF also inhibited wound healing of mesothelial cells, while 7.5% icodextrin-dissolved culture medium without PDF had no inhibitory effects. Glucose suppressed cell motility by inhibiting tyrosine phosphorylation of FAK, formation of focal adhesions, and cell spreading, while icodextrin had no effects on any of these mesothelial cell functions. Our results demonstrate icodextrin to have no adverse effects on wound healing processes of peritoneal mesothelial cells. Preservation of integrin-mediated cell adhesion might be one of the molecular mechanisms accounting for the superior biocompatibility of icodextrin-containing PDF. Copyright © 2012 Elsevier Inc. All rights reserved.

  1. Oscillating PDF in termini of circadian pacemaker neurons and synchronous molecular clocks in downstream neurons are not sufficient for sustenance of activity rhythms in constant darkness.

    PubMed

    Prakash, Pavitra; Nambiar, Aishwarya; Sheeba, Vasu

    2017-01-01

    In Drosophila, neuropeptide Pigment Dispersing Factor (PDF) is expressed in small and large ventral Lateral Neurons (sLNv and lLNv), among which sLNv are critical for activity rhythms in constant darkness. Studies show that this is mediated by rhythmic accumulation and likely secretion of PDF from sLNv dorsal projections, which in turn synchronises molecular oscillations in downstream circadian neurons. Using targeted expression of a neurodegenerative protein Huntingtin in LNv, we evoke a selective loss of neuropeptide PDF and clock protein PERIOD from sLNv soma. However, PDF is not lost from sLNv dorsal projections and lLNv. These flies are behaviourally arrhythmic in constant darkness despite persistence of PDF oscillations in sLNv dorsal projections and synchronous PERIOD oscillations in downstream circadian neurons. We find that PDF oscillations in sLNv dorsal projections are not sufficient for sustenance of activity rhythms in constant darkness and this is suggestive of an additional component that is possibly dependent on sLNv molecular clock and PDF in sLNv soma. Additionally, despite loss of PERIOD in sLNv, their activity rhythms entrain to light/dark cycles indicating that sLNv molecular clocks are not necessary for entrainment. Under constant light, these flies lack PDF from both soma and dorsal projections of sLNv, and when subjected to light/dark cycles, show morning and evening anticipation and accurately phased morning and evening peaks. Thus, under light/dark cycles, PDF in sLNv is not necessary for morning anticipation.

  2. Oscillating PDF in termini of circadian pacemaker neurons and synchronous molecular clocks in downstream neurons are not sufficient for sustenance of activity rhythms in constant darkness

    PubMed Central

    Prakash, Pavitra; Nambiar, Aishwarya; Sheeba, Vasu

    2017-01-01

    In Drosophila, neuropeptide Pigment Dispersing Factor (PDF) is expressed in small and large ventral Lateral Neurons (sLNv and lLNv), among which sLNv are critical for activity rhythms in constant darkness. Studies show that this is mediated by rhythmic accumulation and likely secretion of PDF from sLNv dorsal projections, which in turn synchronises molecular oscillations in downstream circadian neurons. Using targeted expression of a neurodegenerative protein Huntingtin in LNv, we evoke a selective loss of neuropeptide PDF and clock protein PERIOD from sLNv soma. However, PDF is not lost from sLNv dorsal projections and lLNv. These flies are behaviourally arrhythmic in constant darkness despite persistence of PDF oscillations in sLNv dorsal projections and synchronous PERIOD oscillations in downstream circadian neurons. We find that PDF oscillations in sLNv dorsal projections are not sufficient for sustenance of activity rhythms in constant darkness and this is suggestive of an additional component that is possibly dependent on sLNv molecular clock and PDF in sLNv soma. Additionally, despite loss of PERIOD in sLNv, their activity rhythms entrain to light/dark cycles indicating that sLNv molecular clocks are not necessary for entrainment. Under constant light, these flies lack PDF from both soma and dorsal projections of sLNv, and when subjected to light/dark cycles, show morning and evening anticipation and accurately phased morning and evening peaks. Thus, under light/dark cycles, PDF in sLNv is not necessary for morning anticipation. PMID:28558035

  3. PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function.

    PubMed

    Kula, Elzbieta; Levitan, Edwin S; Pyza, Elzbieta; Rosbash, Michael

    2006-04-01

    In Drosophila, the neuropeptide pigment-dispersing factor (PDF) is a likely circadian molecule, secreted by central pacemaker neurons (LNvs). PDF is expressed in both small and large LNvs (sLNvs and lLNvs), and there are striking circadian oscillations of PDF staining intensity in the small cell termini, which require a functional molecular clock. This cycling may be relevant to the proposed role of PDF as a synchronizer of the clock system or as an output signal connecting pacemaker cells to locomotor activity centers. In this study, the authors use a generic neuropeptide fusion protein (atrial natriuretic factor-green fluorescent protein [ANF-GFP]) and show that it can be expressed in the same neurons as PDF itself. Yet, ANF-GFP as well as PDF itself does not manifest any cyclical accumulation in sLNv termini in adult transgenic flies. Surprisingly, the absence of detectable PDF cycling is not accompanied by any detectable behavioral pheno-type, since these transgenic flies have normal morning and evening anticipation in a light-dark cycle (LD) and are fully rhythmic in constant darkness (DD). The molecular clock is also not compromised. The results suggest that robust PDF cycling in sLNv termini plays no more than a minor role in the Drosophila circadian system and is apparently not even necessary for clock output function.

  4. Marketing Internships: A Planning and Implementation Guide.

    ERIC Educational Resources Information Center

    Faught, Suzanne G.

    This planning and implementation guide is designed to assist marketing educators and others supportive of marketing education. It begins with definitions of vocabulary of related terminology and descriptions of the four models of internships presented in the guide: full-year, rotation-type format; 1-semester, rotation-type format; full-year format…

  5. MADE 2. Marketing and Distributive Education Competency Based Curriculum Guide.

    ERIC Educational Resources Information Center

    New Jersey State Dept. of Education, Trenton. Div. of Vocational Education.

    This curriculum guide is one in a series of three competency-based instructional materials dealing with marketing and distributive education (MADE). Covered in the individual sections of the guide are the following topics: job orientation (personal appearance, job opportunities, job interviews, basic skills, training plans, legal requirements, and…

  6. STDs & HIV: A Guide for Today's Teens. 2nd Edition. Instructor's Guide.

    ERIC Educational Resources Information Center

    Yarber, William L.

    This curriculum represents the current approach to prevention education about sexually transmitted diseases (STD) for students in grades 7-12, combining health messages about STD, including HIV/AIDS, into one curriculum. The instructor's guide discusses adolescents' need for STD/HIV prevention education; presents information about the…

  7. The Drug Question: The Constitution and Public Policy. Teacher's Guide.

    ERIC Educational Resources Information Center

    Constitutional Rights Foundation, Los Angeles, CA.

    This teacher's guide complements the student text's presentation of lesson plans on the subject of illegal drug use. The booklet begins with an explanation of the benefits of law-related education (LRE) for democratic education. The guide then outlines suggestions for handling controversy; directing discussion; organizing cooperative and small…

  8. Career Education Instructional Guide.

    ERIC Educational Resources Information Center

    State Univ. of New York, Oswego. Coll. at Oswego. Dept. of Industrial Arts and Technology.

    The guide is designed primarily for industrial arts teachers at the middle school level who wish to integrate career education into their curricula. The lessons and activities attempt to establish a balance among career information, technical information, and hands-on experience. The guide contains six lesson plans which cover the topics: the…

  9. Curriculum Guide for Agriculture.

    ERIC Educational Resources Information Center

    Oregon State Board of Education, Salem. Div. of Community Colleges and Career Education.

    Developed through a cooperative effort by industry and education, this curriculum guide outlines the basic knowledge and skills necessary for entry-level competencies in the broad field of agriculture, or for entrance into a post-high school program. This guide is one of several developed for Oregon's new approach to secondary education called…

  10. Nebraska Secondary Bicycle Program Guide.

    ERIC Educational Resources Information Center

    Tichenor, Fred E.

    Provided is a secondary education bicycle program guide designed for use in a general bicycle awareness course or as part of a driver education course. Chapter 1 of the guide contains the course objectives (psychomotor, cognitive, and affective) and a course outline organized into eight lessons. Each lesson lists lesson objectives, student…

  11. Aerospace Science Education, A Curriculum Guide.

    ERIC Educational Resources Information Center

    Hilburn, Paul

    This curriculum guide was developed by the Alaska State Department of Education for the purpose of aiding elementary and secondary school teachers in incorporating elements of aerospace science in the classroom. The section of the guide designed for elementary school teachers includes chapters under the headings: Aircraft, Airports, Weather,…

  12. Fashion Merchandising. Marketing and Distributive Education.

    ERIC Educational Resources Information Center

    Robertson, Horace C.; And Others

    This curriculum guide was developed to be used as a resource guide to assist marketing and distributive education teachers in planning and teaching a course in fashion merchandising. First, an introductory section is devoted to the management of the fashion merchandising curriculum, including information on the guide's background, units of…

  13. Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Bush, Nancy; And Others

    This curriculum guide recommends the essential content for high school programs in business education in South Carolina. It contains course outlines which are based on competencies needed in the labor market and/or for personal business management. The guide contains 20 course descriptions which are arranged in alphabetical order. Each course is…

  14. California Outdoor School Curriculum Guide.

    ERIC Educational Resources Information Center

    Stoner, Darleen K.; And Others

    This curriculum guide seeks to contribute vision to the values and goals of outdoor education and to show their relevance to all curricular areas. Direction is provided for developing and implementing a dynamic curriculum in outdoor education. The guide is divided into three sections. Section I addresses the informational needs of administrators…

  15. Education & Recycling: Educator's Waste Management Resource and Activity Guide 1994.

    ERIC Educational Resources Information Center

    California State Dept. of Conservation. Sacramento. Div. of Recycling.

    This activity guide for grades K-12 reinforces the concepts of recycling, reducing, and reusing through a series of youth-oriented activities. The guide incorporates a video-based activity, multiple session classroom activities, and activities requiring group participation and student conducted research. Constructivist learning theory was…

  16. Graphic Design: A Career Guide and Education Directory.

    ERIC Educational Resources Information Center

    Poggenpohl, Sharon Helmer, Ed.

    This guide aims to help students make informed decisions about careers in graphic design. The guide defines the purpose and practice of the graphic design field and identifies the strong link between effective educational programs and effective professional practices. Suggestions are given for evaluating schools and potential employers. Comments…

  17. Economic Literacy: An Instructional Guide for Vocational Education.

    ERIC Educational Resources Information Center

    Blackman, Linda L.; And Others

    This instructor's guide consists of materials for use in helping vocational education students acquire basic economic literacy. Addressed in the individual units of the guide are the following topics: worker productivity, the free enterprise system, components of the economy, the consumer as a decision maker, small business functions, economic…

  18. Marketing and Distributive Education. Wholesaling Curriculum Guide.

    ERIC Educational Resources Information Center

    Northern Illinois Univ., DeKalb. Dept. of Business Education and Administration Services.

    This document is one of four curriculum guides designed to provide the curriculum coordinator with a basis for planning a comprehensive program in the field of marketing as well as to provide marketing and distributive education teachers with maximum flexibility. Introductory information provides directions for using the guide and information on…

  19. Marketing and Distributive Education. Food Marketing Curriculum Guide

    ERIC Educational Resources Information Center

    Northern Illinois Univ., DeKalb. Dept. of Business Education and Administration Services.

    This document is one of four curriculum guides designed to provide the curriculum coordinator with a basis for planning a comprehensive program in the field of marketing as well as to provide marketing and distributive education teachers with maximum flexibility. Introductory information provides directions for using the guide and information on…

  20. Industrial Marketing. Marketing and Distributive Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Moore, James R.; And Others

    This guide is designed to provide the curriculum coordinator with a basis for planning a comprehensive program in the field of marketing as well as to provide marketing and distributive education teacher/coordinators with maximum flexibility in planning an industrial marketing curriculum. The guide was constructed by identifying the competencies…

  1. Marketing Services: Insurance. Marketing and Distributive Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Luft, Roger L.; And Others

    This guide is designed to provide the curriculum coordinator with a basis for planning a comprehensive program in the field of marketing as well as to provide marketing and distributive education teacher/coordinators with maximum flexibility in planning an insurance marketing curriculum. The guide was constructed by identifying the competencies…

  2. Driver and Traffic Safety Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Massachusetts State Dept. of Education, Boston. Bureau of Elementary and Secondary Education.

    Materials contained in this Massachusetts curriculum guide are based on concepts and procedures developed by the Highway Users Federation for Safety and Mobility. The guide examines the philosophy of driver education, discusses such legal aspects as certification of students and teachers, presents a comprehensive classroom and behind-the-wheel…

  3. VET Providers Planning to Deliver Degrees: Good Practice Guide

    ERIC Educational Resources Information Center

    National Centre for Vocational Education Research (NCVER), 2015

    2015-01-01

    This good practice guide is intended to assist public and private registered training organisations (RTOs) planning to commence higher education (HE) delivery. The guide is based on research undertaken by Victor Callan and Kaye Bowman, who completed case studies with six providers currently delivering higher education qualifications in addition to…

  4. Service Occupations Cluster Brief. [Vocational Education in Oregon.

    ERIC Educational Resources Information Center

    Brock, Howard

    This guide sets forth minimum approval criteria for service occupations cluster programs in Oregon. The information in the guide is intended for use by district-level curriculum planners, teachers, regional coordinators, or state education department staff involved with new program development or revisions of existing programs. The guide outlines…

  5. Kansas Business Education Curriculum Guide.

    ERIC Educational Resources Information Center

    Groneman, Nancy; Owen, Susan

    This curriculum guide was developed to help business education teachers in Kansas improve and update their curricula to meet the needs of the present and future electronic office. The guide is based upon the premise that computer and keyboarding skills will be needed by all students and that communication skills and knowledge of word…

  6. Curriculum Guide in Sex Education for the TMR.

    ERIC Educational Resources Information Center

    Steward, Kathy L.

    Presented is a sex education curriculum guide for teachers of trainable retarded students ages 12 to 21 years. The guide is divided into six units: body parts, gender identification, and restroom signs; living things; reproduction; growth; adolescence, menstruation, and street language; and maturity (including sexual feelings and birth control).…

  7. Marketing Education Program Management Guide.

    ERIC Educational Resources Information Center

    Blair, Betty; And Others

    This guide was designed for use by marketing education teacher-coordinators and administrators in implementing marketing education programs. The document includes the following: an overall picture of administrative responsibilities related to high quality programs, guidelines and forms needed to deliver effective instruction, resources and…

  8. 77 FR 71831 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on November 8, 2012, pursuant to.... (``the Act''), 3D Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with the... remains open, and 3D PDF intends to file additional written notifications disclosing all changes in...

  9. 77 FR 56861 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3d PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Production Act of 1993--3d PDF Consortium, Inc. Notice is hereby given that, on August 20, 2012, pursuant to.... (``the Act''), 3D Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with the... remains open, and 3D PDF intends to file additional written notifications disclosing all changes in...

  10. The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in Drosophila.

    PubMed

    Zhang, Luoying; Lear, Bridget C; Seluzicki, Adam; Allada, Ravi

    2009-12-15

    Circadian clocks in the brain are organized as coupled oscillators that integrate seasonal cues such as light and temperature to time daily behaviors. In Drosophila, the PIGMENT DISPERSING FACTOR (PDF) neuropeptide-expressing morning (M) and non-PDF evening (E) cells are coupled cell groups important for morning and evening behavior, respectively. Depending on day length, either M cells (short days) or E cells (long days) dictate both the morning and the evening phase, a phenomenon that we term network hierarchy. To examine the role of PDF in light-dark conditions, we examined flies lacking both the PDF receptor (PDFR) and the circadian photoreceptor CRYPTOCHROME (CRY). We found that subsets of E cells exhibit molecular oscillations antiphase to those of wild-type flies, single cry mutants, or single Pdfr mutants, demonstrating a potent role for PDF in light-mediated entrainment, specifically in the absence of CRY. Moreover, we find that the evening behavioral phase is more strongly reset by PDF(+) M cells in the absence of CRY. On the basis of our findings, we propose that CRY can gate PDF signaling to determine behavioral phase and network hierarchy.

  11. Structures of E. coli peptide deformylase bound to formate: insight into the preference for Fe2+ over Zn2+ as the active site metal.

    PubMed

    Jain, Rinku; Hao, Bing; Liu, Ren-Peng; Chan, Michael K

    2005-04-06

    E. coli peptide deformylase (PDF) catalyzes the deformylation of nascent polypeptides generated during protein synthesis. While PDF was originally thought to be a zinc enzyme, subsequent studies revealed that the active site metal is iron. In an attempt to understand this unusual metal preference, high-resolution structures of Fe-, Co-, and Zn-PDF were determined in complex with its deformylation product, formate. In all three structures, the formate ion binds the metal and forms hydrogen-bonding interactions with the backbone nitrogen of Leu91, the amide side chain of Gln50, and the carboxylate side chain of Glu133. One key difference, however, is how the formate binds the metal. In Fe-PDF and Co-PDF, formate binds in a bidentate fashion, while in Zn-PDF, it binds in a monodentate fashion. Importantly, these structural results provide the first clues into the origins of PDF's metal-dependent activity differences. On the basis of these structures, we propose that the basis for the higher activity of Fe-PDF stems from the better ability of iron to bind and activate the tetrahedral transition state required for cleavage of the N-terminal formyl group.

  12. The promoter of a plant defensin gene directs specific expression in nematode-induced syncytia in Arabidopsis roots.

    PubMed

    Siddique, Shahid; Wieczorek, Krzysztof; Szakasits, Dagmar; Kreil, David P; Bohlmann, Holger

    2011-10-01

    The beet cyst nematode Heterodera schachtii induces a feeding site, called syncytium, in roots of host plants. In Arabidopsis, one of the genes whose expression is strongly induced in these structures is Pdf2.1 which codes for an antimicrobial plant defensin. Arabidopsis has 13 plant defensin genes. Besides Pdf2.1, the Pdf2.2 and Pdf2.3 genes were strongly expressed in syncytia and therefore the expression of all three Pdf genes was studied in detail. The promoter of the Pdf2.1 gene turned out to be an interesting candidate to drive a syncytium-specific expression of foreign genes as RT-PCR showed that apart from the feeding site it was only expressed in siliques (seeds). The Pdf2.2 and Pdf2.3 genes were in addition expressed in seedlings, roots, leaves, stems, and flowers. These results were supported by the analysis of promoter::GUS lines. After infection with H. schachtii all GUS lines showed a strong staining in syncytia at 5 and 15 dpi. This expression pattern was confirmed by in situ RT-PCR. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  13. A Guide to Effective Accountability Reporting: Designing Public Reports that Effectively Communicate Accountability, Assessment and Other Quantitative Education Indicators in an Easily Understood Format.

    ERIC Educational Resources Information Center

    Fast, Ellen Forte

    This guide was developed to serve as a resource for the staffs of state education agencies and local education agencies who are responsible for producing state, district, or school report cards of the type required under many state or district accountability systems as well as under the No Child Left Behind Act (NCLB). The guide is not intended to…

  14. Managing a Job, a Family, and Studies. A Guide for Educational Institutions and the Workplace = Coordonner emploi, famille, et etudes. Un guide destine' aux institutions d'enseignement et au milieu du travail.

    ERIC Educational Resources Information Center

    Home, Alice; And Others

    This guide, which presents the findings of a 1994 survey of nearly 500 Canadian women who fulfill family and work responsibilities while studying in social work, nursing, and adult education programs, is designed to help employers, educators, advisors, and administrators deal with the increased numbers of female students attempting to balance…

  15. Stochastic-field cavitation model

    NASA Astrophysics Data System (ADS)

    Dumond, J.; Magagnato, F.; Class, A.

    2013-07-01

    Nonlinear phenomena can often be well described using probability density functions (pdf) and pdf transport models. Traditionally, the simulation of pdf transport requires Monte-Carlo codes based on Lagrangian "particles" or prescribed pdf assumptions including binning techniques. Recently, in the field of combustion, a novel formulation called the stochastic-field method solving pdf transport based on Eulerian fields has been proposed which eliminates the necessity to mix Eulerian and Lagrangian techniques or prescribed pdf assumptions. In the present work, for the first time the stochastic-field method is applied to multi-phase flow and, in particular, to cavitating flow. To validate the proposed stochastic-field cavitation model, two applications are considered. First, sheet cavitation is simulated in a Venturi-type nozzle. The second application is an innovative fluidic diode which exhibits coolant flashing. Agreement with experimental results is obtained for both applications with a fixed set of model constants. The stochastic-field cavitation model captures the wide range of pdf shapes present at different locations.

  16. A cavitation model based on Eulerian stochastic fields

    NASA Astrophysics Data System (ADS)

    Magagnato, F.; Dumond, J.

    2013-12-01

    Non-linear phenomena can often be described using probability density functions (pdf) and pdf transport models. Traditionally the simulation of pdf transport requires Monte-Carlo codes based on Lagrangian "particles" or prescribed pdf assumptions including binning techniques. Recently, in the field of combustion, a novel formulation called the stochastic-field method solving pdf transport based on Eulerian fields has been proposed which eliminates the necessity to mix Eulerian and Lagrangian techniques or prescribed pdf assumptions. In the present work, for the first time the stochastic-field method is applied to multi-phase flow and in particular to cavitating flow. To validate the proposed stochastic-field cavitation model, two applications are considered. Firstly, sheet cavitation is simulated in a Venturi-type nozzle. The second application is an innovative fluidic diode which exhibits coolant flashing. Agreement with experimental results is obtained for both applications with a fixed set of model constants. The stochastic-field cavitation model captures the wide range of pdf shapes present at different locations.

  17. Constraints on the gluon PDF from top quark pair production at hadron colliders

    NASA Astrophysics Data System (ADS)

    Czakon, Michal; Mangano, Michelangelo L.; Mitov, Alexander; Rojo, Juan

    2013-07-01

    Using the recently derived NNLO cross sections [1], we provide NNLO+NNLL theoretical predictions for top quark pair production based on all the available NNLO PDF sets, and compare them with the most precise LHC and Tevatron data. In this comparison we study in detail the PDF uncertainty and the scale, m t and α s dependence of the theoretical predictions for each PDF set. Next, we observe that top quark pair production provides a powerful direct constraint on the gluon PDF at large x, and include Tevatron and LHC top pair data consistently into a global NNLO PDF fit. We then explore the phenomenological consequences of the reduced gluon PDF uncertainties, by showing how they can improve predictions for Beyond the Standard Model processes at the LHC. Finally, we update to full NNLO+NNLL the theoretical predictions for the ratio of top quark cross sections between different LHC center of mass energies, as well as the cross sections for hypothetical heavy fourth-generation quark production at the LHC.

  18. Stochastic-field cavitation model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dumond, J., E-mail: julien.dumond@areva.com; AREVA GmbH, Erlangen, Paul-Gossen-Strasse 100, D-91052 Erlangen; Magagnato, F.

    2013-07-15

    Nonlinear phenomena can often be well described using probability density functions (pdf) and pdf transport models. Traditionally, the simulation of pdf transport requires Monte-Carlo codes based on Lagrangian “particles” or prescribed pdf assumptions including binning techniques. Recently, in the field of combustion, a novel formulation called the stochastic-field method solving pdf transport based on Eulerian fields has been proposed which eliminates the necessity to mix Eulerian and Lagrangian techniques or prescribed pdf assumptions. In the present work, for the first time the stochastic-field method is applied to multi-phase flow and, in particular, to cavitating flow. To validate the proposed stochastic-fieldmore » cavitation model, two applications are considered. First, sheet cavitation is simulated in a Venturi-type nozzle. The second application is an innovative fluidic diode which exhibits coolant flashing. Agreement with experimental results is obtained for both applications with a fixed set of model constants. The stochastic-field cavitation model captures the wide range of pdf shapes present at different locations.« less

  19. The PDF4LHC report on PDFs and LHC data: Results from Run I and preparation for Run II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rojo, Juan; Accardi, Alberto; Ball, Richard D.

    2015-09-16

    The accurate determination of Parton Distribution Functions (PDFs) of the proton is an essential ingredient of the Large Hadron Collider (LHC) program. PDF uncertainties impact a wide range of processes, from Higgs boson characterization and precision Standard Model measurements to New Physics searches. A major recent development in modern PDF analyses has been to exploit the wealth of new information contained in precision measurements from the LHC Run I, as well as progress in tools and methods to include these data in PDF fits. In this report we summarize the information that PDF-sensitive measurements at the LHC have provided somore » far, and review the prospects for further constraining PDFs with data from the recently started Run II. As a result, this document aims to provide useful input to the LHC collaborations to prioritize their PDF-sensitive measurements at Run II, as well as a comprehensive reference for the PDF-fitting collaborations.« less

  20. Texas Adult Education: Soaring Into the 21st Century. An Adult Education Administrator's Guide for Continuous Improvement and Evaluation.

    ERIC Educational Resources Information Center

    Gall, Dan; Payne, Emily Miller; Burger, Phil; Curtis, Evelyn; Douglas, James; Kean, Nona; Parker, Ursula; Perez, Juan; Rosenberg, Sheila; Saucedo-Schwarz, Myrna; Franklin, Effie; Reed, Joseph

    This guide is designed as an aid for the adult education administrator in the pursuit of continuous excellence and quality improvement in adult education programs in Texas. The Acknowledgments section provides an introduction, background, history, and overview of the adult education National Reporting System (NRS); overview of the NRS measures and…

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