Bayesian inference for two-part mixed-effects model using skew distributions, with application to longitudinal semicontinuous alcohol data.

PubMed

Xing, Dongyuan; Huang, Yangxin; Chen, Henian; Zhu, Yiliang; Dagne, Getachew A; Baldwin, Julie

2017-08-01

Semicontinuous data featured with an excessive proportion of zeros and right-skewed continuous positive values arise frequently in practice. One example would be the substance abuse/dependence symptoms data for which a substantial proportion of subjects investigated may report zero. Two-part mixed-effects models have been developed to analyze repeated measures of semicontinuous data from longitudinal studies. In this paper, we propose a flexible two-part mixed-effects model with skew distributions for correlated semicontinuous alcohol data under the framework of a Bayesian approach. The proposed model specification consists of two mixed-effects models linked by the correlated random effects: (i) a model on the occurrence of positive values using a generalized logistic mixed-effects model (Part I); and (ii) a model on the intensity of positive values using a linear mixed-effects model where the model errors follow skew distributions including skew- t and skew-normal distributions (Part II). The proposed method is illustrated with an alcohol abuse/dependence symptoms data from a longitudinal observational study, and the analytic results are reported by comparing potential models under different random-effects structures. Simulation studies are conducted to assess the performance of the proposed models and method.

TORO II simulations of induction heating in ferromagnetic materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adkins, D.R.; Gartling, D.K.; Kelley, J.B.

TORO II is a finite element computer program that is used in the simulation of electric and magnetic fields. This code, which was developed at Sandia National Laboratories, has been coupled with a finite element thermal code, COYOTE II, to predict temperature profiles in inductively heated parts. The development of an effective technique to account for the nonlinear behavior of the magnetic permeability in ferromagnetic parts is one of the more difficult aspects of solving induction heating problems. In the TORO II code, nonlinear, spatially varying magnetic permeability is approximated by an effective permeability on an element-by-element basis that effectivelymore » provides the same energy deposition that is produced when the true permeability is used. This approximation has been found to give an accurate estimate of the volumetric heating distribution in the part, and predicted temperature distributions have been experimentally verified using a medium carbon steel and a 10kW industrial induction heating unit. Work on the model was funded through a Cooperative Research and Development Agreement (CRADA) between the Department of Energy and General Motors` Delphi Saginaw Steering Systems.« less

40 CFR 72.73 - State issuance of Phase II permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.73 State issuance of Phase II permits... permit program under part 70 of this chapter and that has a State Acid Rain program accepted by the Administrator under § 72.71 shall be responsible for administering and enforcing Acid Rain permits effective in...

40 CFR 72.73 - State issuance of Phase II permits.

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.73 State issuance of Phase II permits... permit program under part 70 of this chapter and that has a State Acid Rain program accepted by the Administrator under § 72.71 shall be responsible for administering and enforcing Acid Rain permits effective in...

40 CFR 72.73 - State issuance of Phase II permits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.73 State issuance of Phase II permits... permit program under part 70 of this chapter and that has a State Acid Rain program accepted by the Administrator under § 72.71 shall be responsible for administering and enforcing Acid Rain permits effective in...

40 CFR 72.73 - State issuance of Phase II permits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.73 State issuance of Phase II permits... permit program under part 70 of this chapter and that has a State Acid Rain program accepted by the Administrator under § 72.71 shall be responsible for administering and enforcing Acid Rain permits effective in...

40 CFR 72.73 - State issuance of Phase II permits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) PERMITS REGULATION Acid Rain Phase II Implementation § 72.73 State issuance of Phase II permits... permit program under part 70 of this chapter and that has a State Acid Rain program accepted by the Administrator under § 72.71 shall be responsible for administering and enforcing Acid Rain permits effective in...

Phosphate effects on copper(II) and lead(II) sorption to ferrihydrite

NASA Astrophysics Data System (ADS)

Tiberg, Charlotta; Sjöstedt, Carin; Persson, Ingmar; Gustafsson, Jon Petter

2013-11-01

Transport of lead(II) and copper(II) ions in soil is affected by the soil phosphorus status. Part of the explanation may be that phosphate increases the adsorption of copper(II) and lead(II) to iron (hydr)oxides in soil, but the details of these interactions are poorly known. Knowledge about such mechanisms is important, for example, in risk assessments of contaminated sites and development of remediation methods. We used a combination of batch experiments, extended X-ray absorption fine structure (EXAFS) spectroscopy and surface complexation modeling with the three-plane CD-MUSIC model to study the effect of phosphate on sorption of copper(II) and lead(II) to ferrihydrite. The aim was to identify the surface complexes formed and to derive constants for the surface complexation reactions. In the batch experiments phosphate greatly enhanced the adsorption of copper(II) and lead(II) to ferrihydrite at pH < 6. The largest effects were seen for lead(II).

Water Pollution: Part I, Municipal Wastewaters; Part II, Industrial Wastewaters.

ERIC Educational Resources Information Center

Fowler, K. E. M.

This publication is an annotated bibliography of municipal and industrial wastewater literature. This publication consists of two parts plus appendices. Part one is entitled Municipal Wastewaters and includes publications in such areas as health effects of polluted waters, federal policy and legislation, biology and chemistry of polluted water,…

Mammalian Toxicity of Munition Compounds. Phase II. Effects of Multiple Doses. Part III. 2,6-Dinitrotoluene

DTIC Science & Technology

1976-07-01

Histopathology , Statistical Analysis, and Normal Values ..... ...... ........... 131 I Ii A.mmALIAN TOXICITY OF MUNITION COMPOUNDS PHASE II: Effects of...chemistry tests and histopathology , and the normal values are given in Appendix I. The concentrations of Ca 2+, Mg2 +, Na+ and K+ in serum were determined...mice fed 2,6-DNT included focal epicarditis or myocarditis, focal cystitis, chronic murine pneumonia or bronchopneumonia, metritis and focal myositis

Effect of basic fibroblast growth factor and transforming growth factor β1 on the healing of reconstructed dura by carbon dioxide laser soldering in minipigs.

PubMed

Zhong, Hong-liang; Wang, Zhen-min; Yang, Zhi-jun; Zhao, Fu; Wang, Bo; Wang, Zhong-cheng; Liu, Pi-nan

2012-02-01

Carbon dioxide (CO2) laser soldering is an alternative technique for tissue bonding. Basic fibroblast growth factor (bFGF) and transforming growth factor β(1) (TGFβ(1)) are two key factors for wound healing. This study was performed to demonstrate the efficacy of CO2 laser soldering for dural reconstruction and the effect of bFGF and TGFβ(1) on healing. In Part I, 10 minipigs were randomized into two equal groups. Dural defects were reconstructed by conventional fibrin glue bonding (group I(a)) or CO2 laser soldering (group I(b)). The reconstructed dura was subjected to burst pressure (BP) measurement and immunohistochemical staining after 1 week. In Part II, 36 minipigs were randomized into three equal groups. Dural reconstruction was achieved by CO2 laser soldering. Exogenous bFGF (group II(b)) or TGFβ(1) (group II(c)) was administered while group II(a) served as a control group. The specimens were subjected to BP measurement after 1, 2, 3, and 4 weeks, respectively. In Part I, the dura specimens displayed positive staining of only bFGF in group I(a) and of both bFGF and TGFβ(1) in group I(b). Group I(b) showed higher BP than group I(a) ((98.00 ± 21.41) mmHg vs. (70.80 ± 15.09) mmHg, respectively; P < 0.05). In Part II, BP of group II(c) was significantly higher than that of group II(a) (P < 0.01). The BP of group II(a) trended toward stabilization after 3 weeks of growth, while that of groups II(b) and II(c) trended toward stabilization after 2 weeks of growth. CO2 laser soldering is a reliable technique for dural reconstruction. The superior healing of dural reconstruction by CO2 laser soldering may be related to higher expression of bFGF and TGFβ(1), and CO2 lasers may stimulate their secretion. Exogenous bFGF or TGFβ(1) may improve healing by shortening the wound healing time, and exogenous TGFβ(1) may improve the tensile strength.

Modifying the electronic and optical properties of carbon nanotubes

NASA Astrophysics Data System (ADS)

Kinder, Jesse M.

The intrinsic electronic and optical properties of carbon nanotubes make them promising candidates for circuit elements and LEDs in nanoscale devices. However, applied fields and interactions with the environment can modify these intrinsic properties. This dissertation is a theoretical study of perturbations to an ideal carbon nanotube. It illustrates how transport and optical properties of carbon nanotubes can be adversely affected or intentionally modified by the local environment. The dissertation is divided into three parts. Part I analyzes the effect of a transverse electric field on the single-electron energy spectrum of semiconducting carbon nanotubes. Part II analyzes the effect of the local environment on selection rules and decay pathways relevant to dark excitons. Part III is a series of 26 appendices. Two different models for a transverse electric field are introduced in Part I. The first is a uniform field perpendicular to the nanotube axis. This model suggests the field has little effect on the band gap until it exceeds a critical value that can be tuned with strain or a magnetic field. The second model is a transverse field localized to a small region along the nanotube axis. The field creates a pair of exponentially localized bound states but has no effect on the band gap for particle transport. Part II explores the physics of dark excitons in carbon nanotubes. Two model calculations illustrate the effect of the local environment on allowed optical transitions and nonradiative recombination pathways. The first model illustrates the role of inversion symmetry in the optical spectrum. Broken inversion symmetry may explain low-lying peaks in the exciton spectrum of boron nitride nanotubes and localized photoemission around impurities and interfaces in carbon nanotubes. The second model in Part II suggests that free charge carriers can mediate an efficient nonradiative decay process for dark excitons in carbon nanotubes. The appendices in Part III provide background material and details of calculations relevant to the main text. These appendices may be useful to researchers new to the study of carbon nanotubes.

Effects of designed learning strategies to enhance biology students' understanding of the nature of science

NASA Astrophysics Data System (ADS)

Reeves, Carolyn T.

This research attempted to test the effectiveness of strategies designed for teaching the nature of science to Biology I students and to examine the effects of frequency of use of the strategies. Some strategies were designed to identify misconceptions about the nature of science; others were designed to correct misconceptions or provide correct concepts about the nature of science. This research commenced during the 3rd week of the 2001--2002 school year after obtaining IRB approval and permissions from school officials. The study ended after the 15th week. All participating students were given a pretest and a posttest of the Nature of Scientific Knowledge Scale Enhanced (NSKSE) test. Part I, 48 items, consisted of the NSKS test by Rubba & Anderson (1978). Part II, 10 items, consisted of a test constructed by the researcher. Part I contained questions about 6 tenets of the nature of science. Part II contained questions about how science works. The strategies were tested in two Biology I experimental classes, n = 41, and compared with two Biology I control classes, n = 34, by means of an analysis of covariance with the pretest scores used as the covariate. The overall mean posttest scores of the experimental and the control group were not found to be significantly different on either Part I, F(1,72) = 1.059, p = .307, or Part II, F(1,72) = 3.136, p = .081, of the test instrument. The number of times a strategy was used in each experimental classroom was determined. It was found that strategies were used almost twice as often in one classroom than in the other. A second set of ANCOVA analyses compared mean scores between Experimental Class A, Experimental Class B, and the control group. There was no significant difference between the groups on Part I, F(2,71) = .921, p = .403, but the difference between groups on Part II, F(2,71) = 5.769, p = .005, was significant. A post hoc Scheffe analysis showed that the class using strategies most often differed significantly with the control group, p = .009, but the other class did not, p = .929. This study suggests that frequent use of the designed strategies was effective in helping Biology I students understand some aspects of the nature of science. It also suggests that minimal use of the strategies was not effective.

Bullying in Elementary School: An American Perspective

ERIC Educational Resources Information Center

Conn, Kathleen

2013-01-01

Bullying in elementary schools is a recognized and widespread occurrence that threatens to rob children of their childhood. Part I of this commentary describes existing scientifically-based research on the nature, extent and effects of the phenomenon on children in United States schools. Part II analyzes the effectiveness of bullying prevention…

ANALYSIS OF OPTICAL Fe II EMISSION IN A SAMPLE OF ACTIVE GALACTIC NUCLEUS SPECTRA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kovacevic, Jelena; Popovic, Luka C.; Dimitrijevic, Milan S., E-mail: jkovacevic@aob.bg.ac.r

We present a study of optical Fe II emission in 302 active galactic nuclei (AGNs) selected from the Sloan Digital Sky Survey. We group the strongest Fe II multiplets into three groups according to the lower term of the transition (b{sup 4} F, a{sup 6} S, and a{sup 4} G terms). These approximately correspond to the blue, central, and red parts, respectively, of the 'iron shelf' around H{beta}. We calculate an Fe II template that takes into account transitions into these three terms and an additional group of lines, based on a reconstruction of the spectrum of I Zw 1.more » This Fe II template gives a more precise fit of the Fe II lines in broad-line AGNs than other templates. We extract Fe II, H{alpha}, H{beta}, [O III], and [N II] emission parameters and investigate correlations between them. We find that Fe II lines probably originate in an intermediate line region. We note that the blue, red, and central parts of the iron shelf have different relative intensities in different objects. Their ratios depend on continuum luminosity, FWHM H{beta}, the velocity shift of Fe II, and the H{alpha}/H{beta} flux ratio. We examine the dependence of the well-known anti-correlation between the equivalent widths of Fe II and [O III] on continuum luminosity. We find that there is a Baldwin effect for [O III] but an inverse Baldwin effect for the Fe II emission. The [O III]/Fe II ratio thus decreases with L {sub {lambda}5100}. Since the ratio is a major component of the Boroson and Green Eigenvector 1 (EV1), this implies a connection between the Baldwin effect and EV1 and could be connected with AGN evolution. We find that spectra are different for H{beta} FWHMs greater and less than {approx}3000 km s{sup -1}, and that there are different correlation coefficients between the parameters.« less

30 CFR 950.20 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... regulations including 40 CFR part 1500 et seq. (6) The Endangered Species Act, 16 U.S.C. 1531 et seq., and... accordance with the Act. Article II: Effective Date 3. This Agreement shall take effect following signing by... otherwise stated in this Agreement, the Act, 30 CFR part 745, or other applicable laws or regulations...

30 CFR 950.20 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... regulations including 40 CFR part 1500 et seq. (6) The Endangered Species Act, 16 U.S.C. 1531 et seq., and... accordance with the Act. Article II: Effective Date 3. This Agreement shall take effect following signing by... otherwise stated in this Agreement, the Act, 30 CFR part 745, or other applicable laws or regulations...

30 CFR 950.20 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... regulations including 40 CFR part 1500 et seq. (6) The Endangered Species Act, 16 U.S.C. 1531 et seq., and... accordance with the Act. Article II: Effective Date 3. This Agreement shall take effect following signing by... otherwise stated in this Agreement, the Act, 30 CFR part 745, or other applicable laws or regulations...

30 CFR 950.20 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... regulations including 40 CFR part 1500 et seq. (6) The Endangered Species Act, 16 U.S.C. 1531 et seq., and... accordance with the Act. Article II: Effective Date 3. This Agreement shall take effect following signing by... otherwise stated in this Agreement, the Act, 30 CFR part 745, or other applicable laws or regulations...

30 CFR 950.20 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... regulations including 40 CFR part 1500 et seq. (6) The Endangered Species Act, 16 U.S.C. 1531 et seq., and... accordance with the Act. Article II: Effective Date 3. This Agreement shall take effect following signing by... otherwise stated in this Agreement, the Act, 30 CFR part 745, or other applicable laws or regulations...

Documentation of programs that compute 1) static tilts for a spatially variable slip distribution, and 2) quasi-static tilts produced by an expanding dislocation loop with a spatially variable slip distribution

USGS Publications Warehouse

McHugh, Stuart

1976-01-01

The material in this report is concerned with the effects of a vertically oriented rectangular dislocation loop on the tilts observed at the free surface of an elastic half-space. Part I examines the effect of a spatially variable static strike-slip distribution across the slip surface. The tilt components as a function of distance parallel, or perpendicular, to the strike of the slip surface are displayed for different slip-versus-distance profiles. Part II examines the effect of spatially and temporally variable slip distributions across the dislocation loop on the quasi-static tilts at the free surface of an elastic half space. The model discussed in part II may be used to generate theoretical tilt versus time curves produced by creep events.

Hierarchical competition models with the Allee effect II: the case of immigration.

PubMed

Assas, Laila; Dennis, Brian; Elaydi, Saber; Kwessi, Eddy; Livadiotis, George

2015-01-01

This is part II of an earlier paper that dealt with hierarchical models with the Allee effect but with no immigration. In this paper, we greatly simplify the proofs in part I and provide a proof of the global dynamics of the non-hyperbolic cases that were previously conjectured. Then, we show how immigration to one of the species or to both would, drastically, change the dynamics of the system. It is shown that if the level of immigration to one or to both species is above a specified level, then there will be no extinction region where both species go to extinction.

Strategies for making oral presentations about clinical issues: Part I. At the workplace.

PubMed

Brown, Janet M; Schmidt, Nola A

2009-04-01

This column offers strategies that clinicians can use to make effective oral presentations at work. Part II, which will be published next month, will offer strategies for making oral presentations at professional conferences.

40 CFR 52.2465 - Original identification of plan section.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 2FSD, and pre-dryer 3FSD from Part IV, Rule EX-4, Section 4.41(i) until December 15, 1981, submitted on...) Appendix K (7) Appendix N (8) Appendix P (9) Appendix R I., II.B., II.D., II.E., II.F., II.G., II.H., II.I...) Amendments to Part I, Subpart 1.01 (Certain Terms Defined) and to Part IV, Section 4.52 (former Section 4.705...

Adolescent Health. Volume II: Background and the Effectiveness of Selected Prevention and Treatment Services [and] Indexes to Volumes I, II, and III.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Office of Technology Assessment.

This document, the second of three volumes in the U.S. Congress Office of Technology Assessment's "Adolescent Health" series, provides background information on aspects of adolescents' lives and examines the effectiveness of prevention and treatment interventions. Chapter 1, an introduction to this two-part document, provides a summary of the…

Clothing resultant thermal insulation determined on a movable thermal manikin. Part II: effects of wind and body movement on local insulation

NASA Astrophysics Data System (ADS)

Lu, Yehu; Wang, Faming; Wan, Xianfu; Song, Guowen; Zhang, Chengjiao; Shi, Wen

2015-10-01

Part II of this two-part series study was focused on examining the effects of wind and body movement on local clothing thermal insulation. Seventeen clothing ensembles with different layers (i.e., 1, 2, or 3 layers) were selected for this study. Local thermal insulation with different air velocities (0.15, 1.55, and 4.0 m/s) and walking speeds (0, 0.75, and 1.17 m/s) were investigated on a thermal manikin. Empirical equations for estimating local resultant clothing insulation as a function of local insulation, air velocity, and walking speed were developed. The results showed that the effects of wind and body movement on local resultant thermal resistance are complex and differ distinctively among different body parts. In general, the reductions of local insulation with wind at the chest, abdomen, and pelvis were greater than those at the lower leg and back, and the changes at the body extremity such as the forearm, thigh, and lower leg were higher than such immobile body parts as the chest and back. In addition, the wind effect interacted with the walking effect. This study may have important applications in human local thermal comfort modeling and functional clothing design.

Clothing resultant thermal insulation determined on a movable thermal manikin. Part II: effects of wind and body movement on local insulation.

PubMed

Lu, Yehu; Wang, Faming; Wan, Xianfu; Song, Guowen; Zhang, Chengjiao; Shi, Wen

2015-10-01

Part II of this two-part series study was focused on examining the effects of wind and body movement on local clothing thermal insulation. Seventeen clothing ensembles with different layers (i.e., 1, 2, or 3 layers) were selected for this study. Local thermal insulation with different air velocities (0.15, 1.55, and 4.0 m/s) and walking speeds (0, 0.75, and 1.17 m/s) were investigated on a thermal manikin. Empirical equations for estimating local resultant clothing insulation as a function of local insulation, air velocity, and walking speed were developed. The results showed that the effects of wind and body movement on local resultant thermal resistance are complex and differ distinctively among different body parts. In general, the reductions of local insulation with wind at the chest, abdomen, and pelvis were greater than those at the lower leg and back, and the changes at the body extremity such as the forearm, thigh, and lower leg were higher than such immobile body parts as the chest and back. In addition, the wind effect interacted with the walking effect. This study may have important applications in human local thermal comfort modeling and functional clothing design.

Opportunities for Success: Cost-Effective Programs for Children, Update, 1990. Report together with Additional Minority Views and Dissenting Views of the Select Committee on Children, Youth, and Families, One Hundred First Congress, Second Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

This report on effective programs for children updates the 1988 report by providing new and stronger documentation of the programs' benefits and cost effectiveness. Eight programs and types of programs are discussed in Part I and four program areas that warrant attention are discussed in Part II. Part I reports on: (1) the Special Supplemental…

Issues in the assessment of personality disorder and substance abuse using the Millon Clinical Multiaxial Inventory (MCMI-II).

PubMed

Flynn, P M; McCann, J T; Fairbank, J A

1995-05-01

Substance abuse treatment clients often present other severe mental health problems that affect treatment outcomes. Hence, screening and assessment for psychological distress and personality disorder are an important part of effective treatment, discharge, and aftercare planning. The Millon Clinical Multiaxial Inventory-II (MCMI-II) frequently is used for this purpose. In this paper, several issues of concern to MCMI-II users are addressed. These include the extent to which MCMI-II scales correspond to DSM-III-R disorders; overdiagnosis of disorders using the MCMI-II; accuracy of MCMI-II diagnostic cut-off scores; and the clinical utility of MCMI-II diagnostic algorithms. Approaches to addressing these issues are offered.

19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

10 CFR Appendix II to Part 504 - Fuel Price Computation

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and parameters...

40 CFR Appendix II to Part 1048 - Large Spark-ignition (SI) Composite Transient Cycle

Code of Federal Regulations, 2010 CFR

2010-07-01

... Transient Cycle II Appendix II to Part 1048 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY.... 1048, App. II Appendix II to Part 1048—Large Spark-ignition (SI) Composite Transient Cycle The following table shows the transient duty-cycle for engines that are not constant-speed engines, as described...

75 FR 55269 - Minimum Internal Control Standards for Class II Gaming

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... DEPARTMENT OF THE INTERIOR National Indian Gaming Commission 25 CFR Parts 542 and 543 RIN 3141-AA-37 Minimum Internal Control Standards for Class II Gaming AGENCY: National Indian Gaming Commission. ACTION: Delay of effective date of final rule; request for comments. SUMMARY: The National Indian Gaming...

40 CFR Appendix II to Part 261 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false [Reserved] II Appendix II to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Appendix II to Part 261 [Reserved] ...

A randomized, clinical trial to assess the relative efficacy and tolerability of two doses of etoricoxib versus naproxen in patients with ankylosing spondylitis.

PubMed

Balazcs, Eva; Sieper, Joachim; Bickham, Kara; Mehta, Anish; Frontera, Nancy; Stryszak, Paul; Popmihajlov, Zoran; Peloso, Paul M

2016-10-13

This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS). This was a 2-part, double-blind, active comparator-controlled non-inferiority study in subjects ≥18 years of age with AS. In Part I, subjects were randomized to naproxen 1000 mg; etoricoxib 60 mg, and 90 mg. In Part II, naproxen and etoricoxib 90 mg subjects continued on the same treatment; subjects on etoricoxib 60 mg either continued on 60 mg or escalated to 90 mg. Part I (6 weeks) assessed the efficacy of A) etoricoxib 60 mg vs. naproxen and B) 90 mg vs. naproxen according to the time-weighted average change from baseline in Spinal Pain Intensity (SPI; 0-100 mm VAS) (primary endpoint). The non-inferiority margin was set at 8 mm for SPI. In Part II (20 weeks) we evaluated the potential benefit of increasing from 60 to 90 mg (predefined minimum clinically important difference = 6 mm in SPI) for inadequate responders (<50 % improvement from baseline in SPI) on etoricoxib 60 mg in Part I. In total, 1015 subjects were randomized to receive etoricoxib 60 mg (N = 702), etoricoxib 90 mg (N = 156), and naproxen 1000 mg (N = 157); 70.9 % were male and the mean age was 45.2 years. There were 919 subjects who completed Part I and all continued to Part II. In Part I, SPI change was non-inferior for both etoricoxib doses vs. naproxen. In both Part I and II, the incidence of adverse events (AEs), drug-related AEs, and serious adverse events (SAEs) were similar between the 3 treatment groups. Both doses of etoricoxib were non-inferior to naproxen. All treatments were well tolerated. Etoricoxib 60 and 90 mg effectively control pain in patients with AS, with 60 mg once daily as the lowest effective dose for most patients. Clinical Trials Registry # NCT01208207 . Registered on 22 September 2010.

40 CFR Appendix II to Part 600 - Sample Fuel Economy Calculations

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Sample Fuel Economy Calculations II Appendix II to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. II Appendix II to Part 600—Sample Fuel Economy Calculations (...

10 CFR Appendix II to Part 504 - Fuel Price Computation

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... (APXi). If an alternate fuel other than coal is proposed the source or the derivation of the index must...

Professional Growth & Support Spending Calculator

ERIC Educational Resources Information Center

Education Resource Strategies, 2013

2013-01-01

This "Professional Growth & Support Spending Calculator" helps school systems quantify all current spending aimed at improving teaching effectiveness. Part I provides worksheets to analyze total investment. Part II provides a system for evaluating investments based on purpose, target group, and delivery. In this Spending Calculator…

10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

That Delicate Balance II: Our Bill of Rights. Instructor's Guide.

ERIC Educational Resources Information Center

Kaplan, Howard, Ed.

This instructor's guide assists secondary social studies educators in making effective use of the five-part video series, "That Delicate Balance II: Our Bill of Rights." In the tradition of "The Constitution: That Delicate Balance," the series introduces students to the Bill of Rights and the controversies that have arisen over…

Effects of Newcastle disease virus vaccine antibodies on the shedding and transmission of challenge viruses

USDA-ARS?s Scientific Manuscript database

Different genotypes of avian paramyxovirus serotype-1 virus (APMV-1) circulate in many parts of the world. Traditionally, Newcastle disease virus (NDV) is recognized as having two major divisions represented by class I and class II, with class II being further divided into eighteen genotypes. Alth...

Effects of Newcastle disease virus vaccine antibodies on the shedding and transmission of challenge viruses

USDA-ARS?s Scientific Manuscript database

Different genotypes of avian paramyxovirus serotype-1 virus (APMV-1) circulate in many parts of the world. Traditionally, Newcastle disease virus (NDV) is recognized as having two major divisions represented by class I and class II, with class II being further divided into sixteen genotypes. Althoug...

Conduct a Cost Effectiveness Study of Postgraduate Medical Education Programs. Part I, Part II (Appendixes). Final Report.

ERIC Educational Resources Information Center

Manning, Phillip R.; And Others

To gather data on the effects of different modes of instruction on physician achievement in plotting mean P, O, RS, and T receptiors in electrocardiography, researchers chose a random sample of physicians who had taken a correspondence course on electrocardiography during the previous 5 years from the University of Southern California School of…

Quantitative impact of aerosols on numerical weather prediction. Part II: Impacts to IR radiance assimilation

NASA Astrophysics Data System (ADS)

Marquis, J. W.; Campbell, J. R.; Oyola, M. I.; Ruston, B. C.; Zhang, J.

2017-12-01

This is part II of a two-part series examining the impacts of aerosol particles on weather forecasts. In this study, the aerosol indirect effects on weather forecasts are explored by examining the temperature and moisture analysis associated with assimilating dust contaminated hyperspectral infrared radiances. The dust induced temperature and moisture biases are quantified for different aerosol vertical distribution and loading scenarios. The overall impacts of dust contamination on temperature and moisture forecasts are quantified over the west coast of Africa, with the assistance of aerosol retrievals from AERONET, MPL, and CALIOP. At last, methods for improving hyperspectral infrared data assimilation in dust contaminated regions are proposed.

Experimental Demonstration of Frequency Regulation by Commercial Buildings – Part II: Results and Performance Evaluation

DOE PAGES

Vrettos, Evangelos; Kara, Emre Can; MacDonald, Jason; ...

2016-11-15

This paper is the second part of a two-part series presenting the results from an experimental demonstration of frequency regulation in a commercial building test facility. We developed relevant building models and designed a hierarchical controller for reserve scheduling, building climate control and frequency regulation in Part I. In Part II, we introduce the communication architecture and experiment settings, and present extensive experimental results under frequency regulation. More specifically, we compute the day-ahead reserve capacity of the test facility under different assumptions and conditions. Furthermore, we demonstrate the ability of model predictive control to satisfy comfort constraints under frequency regulation,more » and show that fan speed control can track the fast-moving RegD signal of the Pennsylvania, Jersey, and Maryland Power Market (PJM) very accurately. In addition, we discuss potential effects of frequency regulation on building operation (e.g., increase in energy consumption, oscillations in supply air temperature, and effect on chiller cycling), and provide suggestions for real-world implementation projects. Our results show that hierarchical control is appropriate for frequency regulation from commercial buildings.« less

Biomechanics of the Sensor–Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and Foreign Body Response—Part II: Examples and Application

PubMed Central

Helton, Kristen L; Ratner, Buddy D; Wisniewski, Natalie A

2011-01-01

This article is the second part of a two-part review in which we explore the biomechanics of the sensor–tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I, featured in this issue of Journal of Diabetes Science and Technology, describes a theoretical framework of how biomechanical factors such as motion and pressure (typically micromotion and micropressure) affect tissue physiology around a sensor and in turn, impact sensor performance. Here in Part II, a literature review is presented that summarizes examples of motion or pressure affecting sensor performance. Data are presented that show how both acute and chronic forces can impact continuous glucose monitor signals. Also presented are potential strategies for countering the ill effects of motion and pressure on glucose sensors. Improved engineering and optimized chemical biocompatibility have advanced sensor design and function, but we believe that mechanical biocompatibility, a rarely considered factor, must also be optimized in order to achieve an accurate, long-term, implantable sensor. PMID:21722579

Part II: The Effects of Aromatherapy and Guided Imagery for the Symptom Management of Anxiety, Pain, and Insomnia in Critically Ill Patients: An Integrative Review of Current Literature.

PubMed

Meghani, Naheed; Tracy, Mary Fran; Hadidi, Niloufar Niakosari; Lindquist, Ruth

This review is part II of a 2-part series that presents evidence on the effectiveness of aromatherapy and guided imagery for the symptom management of anxiety, pain, and insomnia in adult critically ill patients. Evidence from this review supports the use of aromatherapy for management of pain, insomnia, and anxiety in critically ill patients. Evidence also supports the use of guided imagery for managing these symptoms in critical care; however, the evidence is sparse, mixed, and weak. More studies with larger samples and stronger designs are needed to further establish efficacy of guided imagery for the management of anxiety, pain, and insomnia of critically ill patients; to accomplish this, standardized evidence-based intervention protocols to ensure comparability and to establish optimal effectiveness are needed. Discussion and recommendations related to the use of these therapies in practice and needs for future research in these areas were generated.

The Role of miR-330-3p/PKC-α Signaling Pathway in Low-Dose Endothelial-Monocyte Activating Polypeptide-II Increasing the Permeability of Blood-Tumor Barrier

PubMed Central

Liu, Jiahui; Liu, Libo; Chao, Shuo; Liu, Yunhui; Liu, Xiaobai; Zheng, Jian; Chen, Jiajia; Gong, Wei; Teng, Hao; Li, Zhen; Wang, Ping; Xue, Yixue

2017-01-01

This study was performed to determine whether EMAP II increases the permeability of the blood-tumor barrier (BTB) by affecting the expression of miR-330-3p as well as its possible mechanisms. We determined the over-expression of miR-330-3p in glioma microvascular endothelial cells (GECs) by Real-time PCR. Endothelial monocyte-activating polypeptide-II (EMAP-II) significantly decreased the expression of miR-330-3p in GECs. Pre-miR-330-3p markedly decreased the permeability of BTB and increased the expression of tight junction (TJ) related proteins ZO-1, occludin and claudin-5, however, anti-miR-330-3p had the opposite effects. Anti-miR-330-3p could enhance the effect of EMAP-II on increasing the permeability of BTB, however, pre-miR-330-3p partly reversed the effect of EMAP-II on that. Similarly, anti-miR-330-3p improved the effects of EMAP-II on increasing the expression levels of PKC-α and p-PKC-α in GECs and pre-miR-330-3p partly reversed the effects. MiR-330-3p could target bind to the 3′UTR of PKC-α. The results of in vivo experiments were similar to those of in vitro experiments. These suggested that EMAP-II could increase the permeability of BTB through inhibiting miR-330-3p which target negative regulation of PKC-α. Pre-miR-330-3p and PKC-α inhibitor decreased the BTB permeability and up-regulated the expression levels of ZO-1, occludin and claudin-5 while anti-miR-330-3p and PKC-α activator brought the reverse effects. Compared with EMAP-II, anti-miR-330-3p and PKC-α activator alone, the combination of the three combinations significantly increased the BTB permeability. EMAP-II combined with anti-miR-330-3p and PKCα activator could enhance the DOX’s effects on inhibiting the cell viabilities and increasing the apoptosis of U87 glioma cells. Our studies suggest that low-dose EMAP-II up-regulates the expression of PKC-α and increases the activity of PKC-α by inhibiting the expression of miR-330-3p, reduces the expression of ZO-1, occludin and claudin-5, and thereby increasing the permeability of BTB. The results can provide a new strategy for the comprehensive treatment of glioma. PMID:29311822

40 CFR 92.1103 - Prohibited acts.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., the sale, the offering for sale, the introduction into commerce, the delivery for introduction into... regulations found in this part. (Introduction into commerce includes placement of a new locomotive or new... effect) under regulations found in this part prior to its introduction into commerce. (ii) In the case of...

A proteomic approach to identifying new drug targets (potentiating topoisomerase II poisons).

PubMed

Jenkins, J R

2008-10-01

Topoisomerase II poisons are an established part of best clinical practice for the treatment of a number of solid tumours and haematological malignancies. However, toxicity and resistance to chemotherapeutic drugs often complicate the treatment. Furthermore, topoisomerase II poisons can also induce sister chromatid exchange, chromosomal recombination and chromosome aberrations and are associated with a significant risk of secondary leukaemia. It would therefore be of great clinical benefit if the efficacy of topoisomerase II inhibitors could be enhanced without the increased toxic side effects. It is proposed that clinical agents targeting topoisomerase II can be enhanced by inhibiting proteins that modulate topoisomerase II. The aim is to identify proteins, that by the nature of their interaction with topoisomerase II, represent putative drug targets.

An Advanced Programming Technique for a Cost-Effective Hardware-Independent Realization of Naval Software Systems. Final Technical Report, Part II.

ERIC Educational Resources Information Center

Computer Symbolic, Inc., Washington, DC.

A pseudo assembly language, PAL, was developed and specified for use as the lowest level in a general, multilevel programing system for the realization of cost-effective, hardware-independent Naval software. The language was developed as part of the system called FIRMS (Fast Iterative Recursive Macro System) and is sufficiently general to allow…

76 FR 1213 - Core Principles and Other Requirements for Swap Execution Facilities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-07

... Part II Commodity Futures Trading Commission 17 CFR Part 37 Core Principles and Other Requirements... RIN Number 3038-AD18 Core Principles and Other Requirements for Swap Execution Facilities AGENCY... Compliance With the Core Principles III. Effective Date and Transition Period IV. Related Matters A...

Mexico: The Socio-Economic and Cultural Environment for Health.

ERIC Educational Resources Information Center

Stambler, Moses

Numerous factors influencing health status and health care in Mexico are reviewed in this paper. Part I covers socioeconomic influences including agricultural and land tenure patterns, oil production, population growth rate, and the extent of poverty. Part II discusses the political environment, emphasizing the effects of politics on strategies…

40 CFR Appendixes I-Ii to Part 268 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

40 CFR Appendixes I-Ii to Part 268 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

40 CFR Appendixes I-Ii to Part 268 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

40 CFR Appendixes I-Ii to Part 268 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

40 CFR Appendixes I-Ii to Part 268 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

Toxic effect of metal cation binary mixtures to the seaweed Gracilaria domingensis (Gracilariales, Rhodophyta).

PubMed

Mendes, Luiz Fernando; Stevani, Cassius Vinicius; Zambotti-Villela, Leonardo; Yokoya, Nair Sumie; Colepicolo, Pio

2014-01-01

The macroalga Gracilaria domingensis is an important resource for the food, pharmaceutical, cosmetic, and biotechnology industries. G. domingensis is at a part of the food web foundation, providing nutrients and microelements to upper levels. As seaweed storage metals in the vacuoles, they are considered the main vectors to magnify these toxic elements. This work describes the evaluation of the toxicity of binary mixtures of available metal cations based on the growth rates of G. domingensis over a 48-h exposure. The interactive effects of each binary mixture were determined using a toxic unit (TU) concept that was the sum of the relative contribution of each toxicant and calculated using the ratio between the toxicant concentration and its endpoint. Mixtures of Cd(II)/Cu(II) and Zn(II)/Ca(II) demonstrated to be additive; Cu(II)/Zn(II), Cu(II)/Mg(II), Cu(II)/Ca(II), Zn(II)/Mg(II), and Ca(II)/Mg(II) mixtures were synergistic, and all interactions studied with Cd(II) were antagonistic. Hypotheses that explain the toxicity of binary mixtures at the molecular level are also suggested. These results represent the first effort to characterize the combined effect of available metal cations, based on the TU concept on seaweed in a total controlled medium. The results presented here are invaluable to the understanding of seaweed metal cation toxicity in the marine environment, the mechanism of toxicity action and how the tolerance of the organism.

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent

PubMed Central

Semprun-Prieto, Laura C.; Sukhanov, Sergiy; Yoshida, Tadashi; Rezk, Bashir M.; Gonzalez-Villalobos, Romer A.; Vaughn, Charlotte; Tabony, A. Michael; Delafontaine, Patrice

2011-01-01

Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47phox−/− mice with vehicle or Ang II for 7 days. Superoxide production was increased 2.4 fold in the skeletal muscle of Ang II infused mice, and this increase was prevented in p47phox−/− mice. Apocynin treatment prevented Ang II-induced superoxide production in skeletal muscle, consistent with Ang II increasing NADPH oxidase derived ROS. Ang II induced loss of body and skeletal muscle weight in C57BL/6J mice, whereas the reduction was significantly attenuated in p47phox−/− animals. The reduction of skeletal muscle weight caused by Ang II was associated with an increase of proteasome activity, and this increase was completely prevented in the skeletal muscle of p47phox−/− mice. In conclusion, Ang II-induced skeletal muscle wasting is in part dependent on NADPH oxidase derived ROS. PMID:21570954

An Analysis of a Finite Element Method for Convection-Diffusion Problems. Part II. A Posteriori Error Estimates and Adaptivity.

DTIC Science & Technology

1983-03-01

AN ANALYSIS OF A FINITE ELEMENT METHOD FOR CONVECTION- DIFFUSION PROBLEMS PART II: A POSTERIORI ERROR ESTIMATES AND ADAPTIVITY by W. G. Szymczak Y 6a...PERIOD COVERED AN ANALYSIS OF A FINITE ELEMENT METHOD FOR final life of the contract CONVECTION- DIFFUSION PROBLEM S. Part II: A POSTERIORI ERROR ...Element Method for Convection- Diffusion Problems. Part II: A Posteriori Error Estimates and Adaptivity W. G. Szvmczak and I. Babu~ka# Laboratory for

How overdrying wood reduces its bonding to phenol-formaldehyde adhesives : a critical review of the literature. Part II, Chemical reactions

Treesearch

Alfred W. Christiansen

1991-01-01

Literature dealing with the effect of excessive drying (overdrying) on wood surface inactivation to bonding is reviewed in two parts and critically evaluated, primarily for phenolic adhesives. Part 1 of the review, published earlier, covers physical mechanisms that could contribute to surface inactivation. The principal physical mechanism is the migration to the...

Aggressive behaviour in children and adolescents. Part I: A review of the effects of child and family characteristics.

PubMed

Fernald, L C; Ani, C; Gardner, J M

1997-12-01

Interpersonal violence is a major public health concern throughout the West Indies, particularly in Jamaica. Many factors contribute to a youth's violent or aggressive behaviour, ranging from individual temperament, to family structure, to large sociocultural influences. In Part I, we review the incidence and severity of violence, and discuss the effects of individual characteristics, and of family structure and discipline. In Part II, the reported effects of school structure, peer relationships and interaction, corporal punishment and the media on violent behaviour in children and adolescents are reviewed, and potential policy implications are discussed.

Driving Forces in Physical, Biological and Socio-economic Phenomena

NASA Astrophysics Data System (ADS)

Roehner, Bertrand M.

2007-05-01

Preface; Part I. Bridging the Gap between Physics and the Social Sciences: 1. Probing bonds; 2. The battle against noise in physics; 3. The battle against noise in the social sciences; 4. Equilibrium and metastable states; 5. Are the data reliable?; Part II. Macro Interactions: Societies and States: 6. Shaping the zeitgeist; 7. Bonds of vassalage; 8. The absentee ownership syndrome; Part III. Micro Interactions: A Network View of Suicide: 9. Effects of male-female imbalance; 10. Effect of weakened marital bonds on suicide; 11. Effect of social isolation on suicide; 12. Apoptosis; 13. Perspectives; References; Index.

Driving Forces in Physical, Biological and Socio-economic Phenomena

NASA Astrophysics Data System (ADS)

Roehner, Bertrand M.

2012-10-01

Preface; Part I. Bridging the Gap between Physics and the Social Sciences: 1. Probing bonds; 2. The battle against noise in physics; 3. The battle against noise in the social sciences; 4. Equilibrium and metastable states; 5. Are the data reliable?; Part II. Macro Interactions: Societies and States: 6. Shaping the zeitgeist; 7. Bonds of vassalage; 8. The absentee ownership syndrome; Part III. Micro Interactions: A Network View of Suicide: 9. Effects of male-female imbalance; 10. Effect of weakened marital bonds on suicide; 11. Effect of social isolation on suicide; 12. Apoptosis; 13. Perspectives; References; Index.

A Survey of Optometry Graduates to Determine Practice Patterns: Part II: Licensure and Practice Establishment Experiences.

ERIC Educational Resources Information Center

Bleimann, Robert L.; Smith, Lee W.

1985-01-01

A summary of Part II of a two-volume study of optometry graduates conducted by the Association of Schools and Colleges of Optometry is presented. Part II includes the analysis of the graduates' licensure and practice establishment experiences. (MLW)

Fertilizing Douglas-fir forests.

Treesearch

Richard E. Miller; Roger D. Right

1979-01-01

This report supplements a slide-tape presentation of the same title. Part I of the report describes the current practice of nitrogen fertilization of Douglas-fir forests in western Washington and Oregon and the effects of this fertilization on tree growth and water quality. Part II discusses factors that affect costs and revenues from investments in forest...

31 CFR 210.3 - Governing law.

Code of Federal Regulations, 2011 CFR

2011-07-01

... CLEARING HOUSE § 210.3 Governing law. (a) Federal law. The rights and obligations of the United States and... rule changes with an effective date on or before September 21, 2007, as published in Parts II, III, and... publishing an amendment to this part in the Federal Register. An amendment to the ACH Rules that is accepted...

Technology Teaching or Mediated Learning, Part II, 1990s: Literacy Linkages and Intervention Contexts.

ERIC Educational Resources Information Center

Coufal, Kathy L.

2002-01-01

Themes during the 1990s included the bootstrapping effects between oral and literate language, importance of supporting emergent literacy, parallels between oral language impairment and academic failure, and challenges in facilitating language learning. This article addresses questions posed in Part I related to use of computer technology for…

Instructional climates in preschool children who are at-risk. Part II: perceived physical competence.

PubMed

Robinson, Leah E; Rudisill, Mary E; Goodway, Jacqueline D

2009-09-01

In Part II of this study, we examined the effect of two 9-week instructional climates (low-autonomy [LA] and mastery motivational climate [MMC]) on perceived physical competence (PPC) in preschoolers (N = 117). Participants were randomly assigned to an LA, MMC, or comparison group. PPC was assessed by a pretest, posttest, and retention test with the Pictorial Scale of Perceived Competence and Social Acceptance. A significant Treatment x Time interaction (p < .001) was present, supporting that MMC participants reported significantly higher PPC scores over time, while no positive changes were present in LA and comparison participants. The results show that an MMC leads to psychological benefits related to achievement motivation. These findings should encourage early childhood educators to consider the effect of instructional climates on children's self-perception.

Intestinal hormones and growth factors: Effects on the small intestine

PubMed Central

Drozdowski, Laurie; Thomson, Alan BR

2009-01-01

There are various hormones and growth factors which may modify the intestinal absorption of nutrients, and which might thereby be useful in a therapeutic setting, such as in persons with short bowel syndrome. In partI, we focus first on insulin-like growth factors, epidermal and transferring growth factors, thyroid hormones and glucocorticosteroids. Part II will detail the effects of glucagon-like peptide (GLP)-2 on intestinal absorption and adaptation, and the potential for an additive effect of GLP2 plus steroids. PMID:19152442

International stem cell tourism and the need for effective regulation. Part II: Developing sound oversight measures and effective patient support.

PubMed

Cohen, Cynthia B; Cohen, Peter J

2010-09-01

Part I of this article, published in the March 2010 issue of the Kennedy Institute of Ethics Journal, traces and addresses the provision of unproven stem cell treatments in Russia and India, examines the concept of innovative treatment, and concludes that stronger regulations are needed to protect the health and informed choices of patients. The current paper, Part II, proposes that the regulatory frameworks for the development of safe and efficacious treatments in effect in the United States and the United Kingdom provide examples of strong oversight measures from which countries seeking to obtain international credibility for their biotechnological competence could draw when developing regulations for stem cell treatments. Major sources of information available to persons who consider receiving such unproven treatments are explored in order to understand and address their concerns. The paper concludes with proposed measures to inform those considering the pursuit of unproven stem cell treatments abroad more accurately about their efficacy and safety and provide them with improved medical and social support in their home countries.

Low- and high-spin iron (II) complexes studied by effective crystal field method combined with molecular mechanics.

PubMed

Darkhovskii, M B; Pletnev, I V; Tchougréeff, A L

2003-11-15

A computational method targeted to Werner-type complexes is developed on the basis of quantum mechanical effective Hamiltonian crystal field (EHCF) methodology (previously proposed for describing electronic structure of transition metal complexes) combined with the Gillespie-Kepert version of molecular mechanics (MM). It is a special version of the hybrid quantum/MM approach. The MM part is responsible for representing the whole molecule, including ligand atoms and metal ion coordination sphere, but leaving out the effects of the d-shell. The quantum mechanical EHCF part is limited to the metal ion d-shell. The method reproduces with reasonable accuracy geometry and spin states of the Fe(II) complexes with monodentate and polydentate aromatic ligands with nitrogen donor atoms. In this setting a single set of MM parameters set is shown to be sufficient for handling all spin states of the complexes under consideration. Copyright 2003 Wiley Periodicals, Inc.

Behind the scene with the fathead team: Part II. In-lab flow through exposures and “omics” to complement effects based monitoring in the Duluth-Superior Harbor.

EPA Science Inventory

As part of a research team focused on aquatic toxicity testing using fathead minnows as a model species, this presentation is the second of a three-part series, giving an overview of the types of field and laboratory studies as well as sample processing our team conducts at the U...

Market-Based Coordination of Thermostatically Controlled Loads—Part II: Unknown Parameters and Case Studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Sen; Zhang, Wei; Lian, Jianming

This two-part paper considers the coordination of a population of Thermostatically Controlled Loads (TCLs) with unknown parameters to achieve group objectives. The problem involves designing the bidding and market clearing strategy to motivate self-interested users to realize efficient energy allocation subject to a peak power constraint. The companion paper (Part I) formulates the problem and proposes a load coordination framework using the mechanism design approach. To address the unknown parameters, Part II of this paper presents a joint state and parameter estimation framework based on the expectation maximization algorithm. The overall framework is then validated using real-world weather data andmore » price data, and is compared with other approaches in terms of aggregated power response. Simulation results indicate that our coordination framework can effectively improve the efficiency of the power grid operations and reduce power congestion at key times.« less

Family Finance Education; An Interdisciplinary Approach. Volume II.

ERIC Educational Resources Information Center

Gibbs, Mary S., Ed.; And Others, Eds.

Volume II of a two-part series related to family finance education provides materials for study and discussion in the 1968 workshop. In Part I, members of the advisory council present their viewpoints concerning an interdisciplinary approach to education in family finance. Part II presents basic and current information related to principal areas…

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation.

PubMed

Martinez, Marilyn N; Gehring, Ronette; Mochel, Jonathan P; Pade, Devendra; Pelligand, Ludovic

2018-05-28

During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1-day session on the influence of population variability on dose-exposure-response relationships. In Part I, we highlighted some of the sources of population variability. Part II provides a summary of discussions on modelling and simulation tools that utilize existing pharmacokinetic data, can integrate drug physicochemical characteristics with species physiological characteristics and dosing information or that combine observed with predicted and in vitro information to explore and describe sources of variability that may influence the safe and effective use of veterinary pharmaceuticals. © 2018 John Wiley & Sons Ltd. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Medical Devices; Hematology and Pathology Devices; Classification of the Whole Slide Imaging System. Final order.

PubMed

2018-01-02

The Food and Drug Administration (FDA or we) is classifying the whole slide imaging system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the whole slide imaging system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

Medical Devices; Clinical Chemistry and Clinical Toxicology Devices; Classification of the Organophosphate Test System. Final order.

PubMed

2017-10-18

The Food and Drug Administration (FDA or we) is classifying the organophosphate test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the organophosphate test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

Medical Devices; Hematology and Pathology Devices; Classification of a Cervical Intraepithelial Neoplasia Test System. Final order.

PubMed

2018-01-03

The Food and Drug Administration (FDA or we) is classifying the cervical intraepithelial neoplasia (CIN) test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the CIN test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

How to unlock the benefits of MRP (materiel requirements planning) II and Just-in-Time.

PubMed

Jacobi, M A

1994-05-01

Manufacturing companies need to use the best and most applicable parts of MRP II and JIT to run their businesses effectively. MRP II provides the methodology to plan and control the total resources of the company and focuses on the processes that add value to their customers' products. It is the cornerstone of total quality management, as it reduces the variability and costly activities in the communication and subsequent execution of the required steps from customer order to shipment. JIT focuses on simplifying the total business operation and execution of business processes. MRP II and JIT are the foundations for successful manufacturing businesses.

Chemiluminescence accompanied by the reaction of acridinium ester and manganese (II).

PubMed

Ren, Lingling; Cui, Hua

2014-11-01

An acridinium ester (AE) alkaline solution can react with Mn(II) to generate a strong chemiluminescence (CL) centered at 435 nm. The effects of reaction conditions such as pH and Mn(II) concentration on CL intensity were examined. In order to explore the CL mechanism, the effect of oxygen on the CL reaction was examined and an X-ray photoelectron spectroscopy study of the reaction precipitate was carried out. The results indicated that oxygen participated in the CL reaction and Mn(IV) was the primary product in the system. A possible mechanism was proposed that involved two pathways: (1) dissolved oxygen was reduced to reactive oxygen radicals by Mn(II), these reactive intermediates then reacted with AE to produce excited state acridone; (2) Mn(II) could reduce AE to partly reduced AE, which then reacted with oxygen to form excited state acridone. The reactions of other metal ions with AE were also tested, and only Mn(II) was shown to trigger strong CL emission of AE, which indicated that the system had good selectivity for Mn(II). Copyright © 2014 John Wiley & Sons, Ltd.

Texas Two-Year College Funding: Issues for the 1990's.

ERIC Educational Resources Information Center

Cloud, Robert C.

An overview is provided of trends and issues in the financial support of Texas's community colleges. Part I provides introductory comments on the functions, enrollments, and costs of the state's public community college system. Part II reviews nationwide trends in the state and local support of two-year colleges, effects of declining revenues,…

Automatic Dictionary Construction; Part II of Scientific Report No. ISR-18, Information Storage and Retrieval...

ERIC Educational Resources Information Center

Cornell Univ., Ithaca, NY. Dept. of Computer Science.

Part Two of the eighteenth report on Salton's Magical Automatic Retriever of Texts (SMART) project is composed of three papers: The first: "The Effect of Common Words and Synonyms on Retrieval Performance" by D. Bergmark discloses that removal of common words from the query and document vectors significantly increases precision and that…

The health effects of depleted uranium munitions: a summary.

PubMed

2002-06-01

There has been a substantial amount of public discussion on the health effects of the use of depleted uranium (DU) munitions. In response to this concern the Royal Society set up an independent, expert working group to investigate the health effects of DU munitions. The Royal Society has now produced two reports, and this summary covering the key conclusions and recommendations from both reports. The part I report considered the increased risks of radiation-induced cancer from exposures to DU on the battlefield. Part II dealt with the risks from the chemical toxicity of uranium, non-malignant radiation effects from DU intakes, the long-term environmental consequences of the deployment of DU munitions and responses to part I including issues arising at a public meeting to discuss the part I report.

10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false NRC and EPA Requirements for Preclosure Repository... SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and EPA Requirements for Preclosure Repository Performance Under proposed 40 CFR part 191, subpart A...

The effects of fluoride concentration and the level of cariogenic challenge on caries development in desalivated rats.

PubMed

Tabchoury, C M; Holt, T; Pearson, S K; Bowen, W H

1998-12-01

Dental caries is an infectious and transmissible disease that continues to affect the majority of people. The presence of carbohydrate, mainly sucrose in the diet, is an important factor in its occurrence. The amount of fluoride required for optimal protective effect where there is a high caries challenge is unclear. Differences in the intensity of cariogenic challenge, for whatever reason, may play a part in determining fluctuations in the effectiveness of fluoride. The purpose of this study was to evaluate the effect of different concentrations of fluoride on the development of caries and explore the cariostatic effect of fluoride under various levels of cariogenic challenge. The study comprises two experiments. In experiment I, 60 desalivated Sprague Dawley rats infected with Streptococcus sobrinus were offered the following to drink for 21 days: group (1), sterile distilled water (SDW); (2) 10 parts/10(6) F SDW; (3) 20 parts/10(6) F SDW; (4) 30 parts/10(6) F SDW; (5) 40 parts/10(6) F SDW. In experiment II, eight groups of 9 rats were placed in a König Höfer programmed feeder and were exposed to different levels of cariogenic challenge through varying frequency of eating and offered water containing 10 parts/10(6) F. In experiment I, exposure to 20, 30 and 40 parts/10(6) F reduced caries development significantly: fluoride, at 10 parts/10(6), reduced the severity of the carious lesions. In this model of severe cariogenic challenge, the results suggest that elevated concentrations of fluoride might be effective in patients at high caries risk. In experiment II, fluoride reduced the incidence and severity of smooth-surface caries in all groups. The protective effect of fluoride decreased as the number of exposures to sugar increased. It is concluded that the effectiveness of fluoride is influenced by the level of cariogenic challenge and that consideration should be given to adjusting the level of fluoride exposure based on perceived caries risk, and that there is a maximum therapeutic effect of fluoride beyond which no additional protection can be expected.

A Dynamic Model of the Initial Spares Support List Development Process

DTIC Science & Technology

1979-06-01

S117Z1NOTE NREI -NOT READI END ITERS IIT7INOTE GPEI -QUANTITY OF PARTS M. END ITER 11775NOTE FUSERF -PARTS USE RATE FACTOR U8WOTE OP U -OTHER PARTS USE...FAILURES ’I 1675R PtJER.L=(NREI.K) (QPEI) (PUSERF.K)+OPUR II7HNOTE PUSER -PARTS USE RATE II7t5NOTE NREI -NOT READY END ITEMS II756NOTE GPEI -QUANTITY

46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

Code of Federal Regulations, 2013 CFR

2013-10-01

.../cm2. ......do kPa 1×10 3 N/m 2. Temperature Degree Celsius °C 5/9 (°F-32). Viscosity milli-Pascal... 46 Shipping 5 2013-10-01 2013-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153... common metric Force Newton N 0.225 lbs. Length Meter m 39.37 in. Centimeter cm .3937 in. Pressure Pascal...

46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

Code of Federal Regulations, 2012 CFR

2012-10-01

.../cm2. ......do kPa 1×10 3 N/m 2. Temperature Degree Celsius °C 5/9 (°F-32). Viscosity milli-Pascal... 46 Shipping 5 2012-10-01 2012-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153... common metric Force Newton N 0.225 lbs. Length Meter m 39.37 in. Centimeter cm .3937 in. Pressure Pascal...

46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

Code of Federal Regulations, 2014 CFR

2014-10-01

.../cm2. ......do kPa 1×10 3 N/m 2. Temperature Degree Celsius °C 5/9 (°F-32). Viscosity milli-Pascal... 46 Shipping 5 2014-10-01 2014-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153... common metric Force Newton N 0.225 lbs. Length Meter m 39.37 in. Centimeter cm .3937 in. Pressure Pascal...

A Visit to Eynsham County Primary School (Part II)

ERIC Educational Resources Information Center

Madera, Kathryn

1974-01-01

An evaluation of the Eynsham County Primary School, uses the seven criteria suggested by the Spodek early childhood education analysis framework: assumptions, goals, curriculum, method, style, organization, and effectiveness. (CS)

Locomotor activity and tissue levels following acute administration of lambda- and gamma-cyhalothrin in rats

EPA Science Inventory

Pyrethroids produce neurotoxicity that depends, in part, on the chemical structure. Common behavioral effects include locomotor activity changes and specific toxic syndromes (types I and II). In general these neurobehavioral effects correlate well with peak internal dose metric...

Report submitted to the trail smelter arbitral tribunal. Part I. Operational features of trail smelter. Part II. Meteorological investigations in Columbia River Valley near trail, by E. Wendell Hewson, Consulting Meteorologist to trail smelter, and Gerald C. Gill, Meteorological Service of Canada. Part III. Provisional regulations adopted during trail period and their effectiveness. Appendix. Final regime prescribed by tribunal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dean, R.S.; Swain, R.E.

1944-01-01

The toxic effects of SO/sub 2/ emitted by a metals smelter at Trail, British Columbia, on vegetation in parts of Washington State during 1900 to 1938, compensation paid, the effectiveness of remedial measures, and studies on the influence of meteorological conditions on atmospheric diffusion processes in the region are reviewed. The findings of an Arbitral Tribunal set up by the USA and Canadian governments in 1935 are reported. (CH)

Final Report for Dynamic Models for Causal Analysis of Panel Data. Models for Change in Quantitative Variables, Part I Deterministic Models. Part II, Chapter 3.

ERIC Educational Resources Information Center

Hannan, Michael T.

This document is part of a series of chapters described in SO 011 759. Addressing the question of effective models to measure change and the change process, the author suggests that linear structural equation systems may be viewed as steady state outcomes of continuous-change models and have rich sociological grounding. Two interpretations of the…

Part I: Virtual Laboratory versus Traditional Laboratory: Which Is More Effective for Teaching Electrochemistry? Part II: The Green Synthesis of Aurones Using a Deep Eutectic Solvent

ERIC Educational Resources Information Center

Hawkins, Ian C.

2013-01-01

The role of the teaching laboratory in science education has been debated over the last century. The goals and purposes of the laboratory are still debated and while most science educators consider laboratory a vital part of the education process, they differ widely on the purposes for laboratory and what methods should be used to teach…

78 FR 9057 - Medicare Program; Request for Information on the Use of Clinical Quality Measures (CQMs) Reported...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

... Part II: Lifelong Learning and Self-Assessment Part III: Cognitive Expertise Part IV: Practice...: Licensure and Professional Standing Part II: Lifelong Learning and Self-Assessment Part III: Cognitive...\\ The MOC assesses physicians' commitment to lifelong learning according to the following six core...

40 CFR Appendix II to Part 86 - Temperature Schedules

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

40 CFR Appendix II to Part 86 - Temperature Schedules

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

40 CFR Appendix II to Part 86 - Temperature Schedules

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

40 CFR Appendix II to Part 86 - Temperature Schedules

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

A Multilevel Analysis of Phase II of the Louisiana School Effectiveness Study.

ERIC Educational Resources Information Center

Kennedy, Eugene; And Others

This paper presents findings of a study that used conventional modeling strategies (student- and school-level) and a new multilevel modeling strategy, Hierarchical Linear Modeling, to investigate school effects on student-achievement outcomes for data collected as part of Phase 2 of the Louisiana School Effectiveness Study. The purpose was to…

42 CFR 412.308 - Determining and updating the Federal rate.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., changes in the case mix index, the effect of changes to DRG classification and relative weights, and... increase attributable to changes in case mix. (ii) Effective FY 1996. Effective FY 1996, the standard... under the Federal rate for outlier cases under subpart F of this part, determined as a proportion of...

Teacher Effectiveness Research. Part II: Special Topics. Bibliographies in Education No. 78.

ERIC Educational Resources Information Center

Gilliss, Geraldine; Moll, Marita

This 723-item bibliography lists materials on teacher effectiveness research published from 1978 to early 1984. Reference to some earlier works of significance is also included. Teacher effectiveness research is here defined to include principally studies conducted in the presage-context-process-product tradition in an attempt to determine…

17 CFR 405.2 - Reports to be made by registered government securities brokers and dealers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... government securities broker or dealer shall file Part I of Form BD-Y2K (§ 249.618 of this title) prepared as..., shall file Part II of Form BD-Y2K (§ 249.618 of this title). Part II of Form BD-Y2K shall address each... registered government securities broker or dealer that was not required to file Part II of Form BD-Y2K under...

Basic Services for Children: A Continuing Search for Learning Priorities. A Dossier for Initiating a Dialogue--Part II, 1978. Experiments and Innovations in Education No. 37.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

Both parts I and II of the dossier are collections of selected activities directed toward the deprived young in a developing world. This book, part II, departs from its predecessor in that it takes a more global view of education services to both children and adults in developing countries. Part A discusses the philosophy and scope of the dossier.…

Investigation of sorption/desorption equilibria of heavy metal ions on/from quartz using rhamnolipid biosurfactant.

PubMed

Aşçi, Yeliz; Nurbaş, Macid; Sağ Açikel, Yeşim

2010-01-01

In the present study, the sorption characteristics of Cd(II) and Zn(II) ions on quartz, a representative soil-component, and the desorption of these metal ions from quartz using rhamnolipid biosurfactant were investigated. In the first part of the studies, the effects of initial metal ion concentration and pH on sorption of Cd(II) and Zn(II) ions by a fixed amount of quartz (1.5g) were studied in laboratory batch mode. The equilibrium sorption capacity for Cd(II) and Zn(II) ions was measured and the best correlation between experimental and model predicted equilibrium uptake was obtained using the Freundlich model. Although investigations on the desorption of heavy metal ions from the main soil-components are crucial to better understand the mobility and bioavailability of metals in the environment, studies on the description of desorption equilibrium were performed rarely. In the second part, the desorption of Cd(II) and Zn(II) from quartz using rhamnolipid biosurfactant was investigated as a function of pH, rhamnolipid concentration, and the amounts of sorbed Cd(II) and Zn(II) ions by quartz. The Freundlich model was also well fitted to the obtained desorption isotherms. Several indexes were calculated based on the differences of the quantity of Cd-Zn sorbed and desorbed. A desorption hysteresis (irreversibility) index based on the Freundlich exponent, concentration-dependent metal distribution coefficients, and the irreversibility index based on the metal distribution coefficient were used to quantify hysteretic behavior observed in the systems. 2009 Elsevier Ltd. All rights reserved.

40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

Aspects of Protein, Chemistry, Part II: Oxygen-Binding Proteins

ERIC Educational Resources Information Center

Nixon, J. E.

1977-01-01

Compares differences in function and behavior of two oxygen-binding proteins, myoglobin found in muscle and hemoglobin found in blood. Describes the mechanism of oxygen-binding and allosteric effect in hemoglobin; also describes the effect of pH on the affinity of hemoglobin for oxygen. (CS)

Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: importance of zinc ions.

PubMed

Brun, Nadja Rebecca; Lenz, Markus; Wehrli, Bernhard; Fent, Karl

2014-04-01

The increasing use of zinc oxide nanoparticles (nZnO) and their associated environmental occurrence make it necessary to assess their potential effects on aquatic organisms. Upon water contact, nZnO dissolve partially to zinc (Zn(II)). To date it is not yet completely understood, whether effects of nZnO are solely or partly due to dissolved Zn(II). Here we compare potential effects of 0.2, 1 and 5mg/L nZnO and corresponding concentrations of released Zn(II) by water soluble ZnCl2 to two development stages of zebrafish, embryos and eleuthero-embryos, by analysing expressional changes by RT-qPCR. Another objective was to assess uptake and tissue distribution of Zn(II). Laser ablation-ICP-MS analysis demonstrated that uptake and tissue distribution of Zn(II) were identical for nZnO and ZnCl2 in eleuthero-embryos. Zn(II) was found particularly in the retina/pigment layer of eyes and brain. Both nZnO and dissolved Zn(II) derived from ZnCl2 had similar inhibiting effects on hatching, and they induced similar expressional changes of target genes. At 72hours post fertilization (hpf), both nZnO and Zn(II) delayed hatching at all doses, and inhibited hatching at 1 and 5 mg/L at 96 hpf. Both nZnO and Zn(II) lead to induction of metallothionein (mt2) in both embryos and eleuthero-embryos at all concentrations. Transcripts of oxidative stress related genes cat and Cu/Zn sod were also altered. Moreover, we show for the first time that nZnO exposure results in transcriptional changes of pro-inflammatory cytokines IL-1β and TNFα. Overall, transcriptional alterations were higher in embryos than eleuthero-embryos. The similarities of the effects lead to the conclusion that effects of nZnO are mainly related to the release of Zn(II). Copyright © 2014 Elsevier B.V. All rights reserved.

Introduction A l'Etude de la Médecine Expérimentale--surgical revolution part II.

PubMed

Toledo-Pereyra, Luis H

2009-01-01

The book that Claude Bernard (1813-1878) published in 1865, the Introduction à l'Etude de la Médecine Expérimentale, fostered a revolution that we believe influenced the practice of surgery when the discipline became a scientific enterprise. In Part I, we set the stage by presenting the life and accomplishments of Bernard, by reviewing his science, and introducing his experimental medicine work. In this issue in Part II, we further analyze his book and determine the "why" of a genuine surgical revolution. What were the factors that generated this revolution, and how a new generation of surgeons learned to become better researchers, and thus better surgeons, were the main objectives of this work. Science, research, and surgery became highly intertwined and the surgeon pursued these fields of knowledge more effectively.

Current Issues in Maternal and Paternal Deprivation. Unit for Child Studies Selected Papers Number 6.

ERIC Educational Resources Information Center

Phillips, Shelley

An overview of some major current issues in maternal and paternal deprivation is presented. Parts I and II focus on (1) single parents and issues in paternal deprivation and (2) sex stereotyping and issues in maternal deprivation, respectively. More particularly, Part I discusses the effects of divorce and death on children and the problem of…

40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Laboratory Testing II.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld engines with the following steady-state duty cycle: G3 mode No. Engine speed a Torque(percent) b Weighting...

AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

ScienceCinema

None

2017-12-09

Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

Transformation of Unsaturated Fatty Acids/Esters to Corresponding Keto Fatty Acids/Esters by Aerobic Oxidation with Pd(II)/Lewis Acid Catalyst.

PubMed

Senan, Ahmed M; Zhang, Sicheng; Zeng, Miao; Chen, Zhuqi; Yin, Guochuan

2017-08-16

Utilization of renewable biomass to partly replace the fossil resources in industrial applications has attracted attention due to the limited fossil feedstock with the increased environmental concerns. This work introduced a modified Wacker-type oxidation for transformation of unsaturated fatty acids/esters to the corresponding keto fatty acids/esters, in which Cu 2+ cation was replaced with common nonredox metal ions, that is, a novel Pd(II)/Lewis acid (LA) catalyst. It was found that adding nonredox metal ions can effectively promote Pd(II)-catalyzed oxidation of unsaturated fatty acids/esters to the corresponding keto fatty acids/esters, even much better than Cu 2+ , and the promotional effect is highly dependent on the Lewis acidity of added nonredox metal ions. The improved catalytic efficiency is attributed to the formation of heterobimetallic Pd(II)/LA species, and the oxidation mechanism of this Pd(II)/LA catalyst is also briefly discussed.

Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinga, K.R.

Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base.

12 CFR 711.4 - Interlocking relationships permitted by statute.

Code of Federal Regulations, 2013 CFR

2013-01-01

... U.S.C. 611 et seq., respectively) (Edge Corporations and Agreement Corporations); (c) A credit union... anticompetitive effect in financial services in any part of the United States; (ii) The service would lead to...

12 CFR 711.4 - Interlocking relationships permitted by statute.

Code of Federal Regulations, 2010 CFR

2010-01-01

... U.S.C. 611 et seq., respectively) (Edge Corporations and Agreement Corporations); (c) A credit union... anticompetitive effect in financial services in any part of the United States; (ii) The service would lead to...

12 CFR 711.4 - Interlocking relationships permitted by statute.

Code of Federal Regulations, 2014 CFR

2014-01-01

... U.S.C. 611 et seq., respectively) (Edge Corporations and Agreement Corporations); (c) A credit union... anticompetitive effect in financial services in any part of the United States; (ii) The service would lead to...

12 CFR 711.4 - Interlocking relationships permitted by statute.

Code of Federal Regulations, 2011 CFR

2011-01-01

... U.S.C. 611 et seq., respectively) (Edge Corporations and Agreement Corporations); (c) A credit union... anticompetitive effect in financial services in any part of the United States; (ii) The service would lead to...

12 CFR 711.4 - Interlocking relationships permitted by statute.

Code of Federal Regulations, 2012 CFR

2012-01-01

... U.S.C. 611 et seq., respectively) (Edge Corporations and Agreement Corporations); (c) A credit union... anticompetitive effect in financial services in any part of the United States; (ii) The service would lead to...

Medical Devices; Hematology and Pathology Devices; Classification of the Flow Cytometric Test System for Hematopoietic Neoplasms. Final order.

PubMed

2017-12-27

The Food and Drug Administration (FDA or we) is classifying the flow cytometric test system for hematopoietic neoplasms into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the flow cytometric test system for hematopoietic neoplasms' classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries.

PubMed

Fransen, Paul; Van Hove, Cor E; Leloup, Arthur J A; Schrijvers, Dorien M; De Meyer, Guido R Y; De Keulenaer, Gilles W

2016-02-01

Arterial hypertension (AHT) affects the voltage dependency of L-type Ca(2+) channels in cardiomyocytes. We analyzed the effect of angiotensin II (AngII)-induced AHT on L-type Ca(2+) channel-mediated isometric contractions in conduit arteries. AHT was induced in C57Bl6 mice with AngII-filled osmotic mini-pumps (4 weeks). Normotensive mice treated with saline-filled osmotic mini-pumps were used for comparison. Voltage-dependent contractions mediated by L-type Ca(2+) channels were studied in vaso-reactive studies in vitro in isolated aortic and femoral arteries by using extracellular K(+) concentration-response (KDR) experiments. In aortic segments, AngII-induced AHT significantly sensitized isometric contractions induced by elevated extracellular K(+) and depolarization. This sensitization was partly prevented by normalizing blood pressure with hydralazine, suggesting that it was caused by AHT rather than by direct AngII effects on aortic smooth muscle cells. The EC50 for extracellular K(+) obtained in vitro correlated significantly with the rise in arterial blood pressure induced by AngII in vivo. The AHT-induced sensitization persisted when aortic segments were exposed to levcromakalim or to inhibitors of basal nitric oxide release. Consistent with these observations, AngII-treatment also sensitized the vaso-relaxing effects of the L-type Ca(2+) channel blocker diltiazem during K(+)-induced contractions. Unlike aorta, AngII-treatment desensitized the isometric contractions to depolarization in femoral arteries pointing to vascular bed specific responses of arteries to hypertension. AHT affects the voltage-dependent L-type Ca(2+) channel-mediated contraction of conduit arteries. This effect may contribute to the decreased vascular compliance in AHT and explain the efficacy of Ca(2+) channel blockers to reduce vascular stiffness and central blood pressure in AHT.

78 FR 24392 - Agency Information Collection Activities; Comment Request; Evaluation and Accountability Report...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... effectiveness of Title II, Part D formula and competitive grant-funded projects, activities and strategies in... and strategies that effectively infuse technology with curriculum and instruction, show evidence of positive impacts for student learning, and can be widely replicated by other State educational agencies and...

The Conveyor Belt Curriculum? Poetry Teaching in the Secondary School: Part II.

ERIC Educational Resources Information Center

Benton, Peter

2000-01-01

Focuses on the effects of the British National Curriculum and the SATs on teaching and changes in how poetry is examined. States that some teachers view these changes as having a detrimental effect on student poetry experiences, while others see a positive advantage in the changes. (CMK)

Fourth - generation languages. Volume 2. Representative 4GLs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, J.

1986-01-01

The chapters in Part II each describe one representative product marketed by a vendor other than IBM. (Volume III of this work covers IBM languages.) The chapters in Part II cover the following 4GLs: ADS/ONLINE, APPLICATION FACTORY, DATATRIEVE, FOCUS, IDEAL, INTELLECT, MANTIS, MIMER, NATURAL, NOMAD2, RAMIS II, SYSTEM W, and USE-IT. The Perspective section of Part II presents a general overview of the product and describes its role in the marketplace. The Tutorial section describes how a user employs the language in application development.

Innovative grinding wheel design for cost-effective machining of advanced ceramics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Licht, R.H.; Kuo, P.; Liu, S.

2000-05-01

This Final Report covers the Phase II Innovative Grinding Wheel (IGW) program in which Norton Company successfully developed a novel grinding wheel for cost-effective cylindrical grinding of advanced ceramics. In 1995, Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics using small prototype wheels. The Phase II program was initiated to scale-up the new superabrasive wheel specification to larger diameters, 305-mm to 406-mm, required for most production grinding of cylindrical ceramic parts, and to perform in-house and independent validation grinding tests.

Low Friction Hull Coatings for Icebreakers. Phase II, Parts I and II. Laboratory and Field Tests

DTIC Science & Technology

1976-02-01

is a hybrid of the above systems . It contains no solvent, can cure at room temperature, is flexible and exhibits good wear characteristics. This...31 Figure I-12 Schematic of Humidity Control System Figure I-13 Effect of Velocity on the Friction Coefficient of...Application of a Conventional Epoxy System and a Vinyl Antifoul Photographs of the USCG Cutter Mackinaw during and after Application of Polyurethane Coating

The effect of losartan and carvedilol on vasopressor responses to adrenergic agonists and angiotensin II in the systemic circulation of Sprague Dawley rats.

PubMed

Abdulla, M H; Sattar, M A; Abdullah, N A; Khan, M A H; Anand Swarup, K R L; Johns, E J

2011-01-01

1 Interaction between renin-angiotensin (RAS) and sympathetic nervous systems (SNS) was investigated by examining the effect of cumulative blockade of angiotensin II (Ang II) and adrenergic receptors in normal Sprague Dawley rats. 2 Rats were treated with losartan (10 mg/kg), carvedilol (5 mg/kg), or losartan plus carvedilol (10+5 mg/kg) orally for 7 days. On day 8, the animals were anaesthetized with pentobarbitone and prepared for systemic haemodynamic study. Dose-response relationships for the elevation of mean arterial pressure or change in heart rate (HR) in response to intravenous injections of noradrenaline (NA), phenylephrine (PE), methoxamine (ME) and Ang II were determined. 3 Losartan or the combination of losartan with carvedilol blunted vasopressor responses to ME and Ang II. Dose-response relationships for agonist action on HR were significantly inhibited by all treatments except for the combination of losartan and carvedilol on the decrease in HR induced by PE. Carvedilol decreased vasopressor responses to NA, PE and Ang II, and HR responses to NA, ME and Ang II. Combination treatment produced similar effects to losartan on the vasopressor and HR responses but had a greater effect on vasopressor responses to ME and Ang II, and on HR responses to NA and Ang II than carvedilol alone. 4 It is concluded that peripheral vasoconstriction induced by Ang II is partly mediated by adrenergic action and that the vasopressor responses to adrenergic agonists depend on an intact RAS. These observations suggest an interactive relationship between RAS and SNS in determining systemic haemodynamic responses in 'normal' rats. © 2010 Blackwell Publishing Ltd.

40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Steady-State Duty Cycles II Appendix..., App. II Appendix II to Part 1042—Steady-State Duty Cycles (a) The following duty cycles apply as specified in § 1042.505(b)(1): (1) The following duty cycle applies for discrete-mode testing: E3 mode No...

40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

Code of Federal Regulations, 2013 CFR

2013-07-01

... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

Code of Federal Regulations, 2012 CFR

2012-07-01

... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

Code of Federal Regulations, 2014 CFR

2014-07-01

... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a b c Grams/liter coating (minus water and...

40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

Code of Federal Regulations, 2010 CFR

2010-07-01

... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

Code of Federal Regulations, 2011 CFR

2011-07-01

... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

12 CFR 163.22 - Merger, consolidation, purchase or sale of assets, or assumption of liabilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... part of the United States; or (ii) The effect of the transaction on any section of the country may be... of trade, unless the OCC finds that the anticompetitive effects of the proposed transaction are clearly outweighed in the public interest by the probable effect of the transaction in meeting the...

12 CFR 163.22 - Merger, consolidation, purchase or sale of assets, or assumption of liabilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... part of the United States; or (ii) The effect of the transaction on any section of the country may be... of trade, unless the OCC finds that the anticompetitive effects of the proposed transaction are clearly outweighed in the public interest by the probable effect of the transaction in meeting the...

12 CFR 163.22 - Merger, consolidation, purchase or sale of assets, or assumption of liabilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... part of the United States; or (ii) The effect of the transaction on any section of the country may be... of trade, unless the OCC finds that the anticompetitive effects of the proposed transaction are clearly outweighed in the public interest by the probable effect of the transaction in meeting the...

31 CFR Appendix II to Part 13 - Form of Bill for Reimbursement

Code of Federal Regulations, 2010 CFR

2010-07-01

... title) of ______ (Country) to participate in the work of ______ (International Organization) or occurring at the _______ (Permanent or observer mission) to ______ (International organization) during the.... II Appendix II to Part 13—Form of Bill for Reimbursement I hereby request that ______ (Governmental...

On understanding the very different science premises meaningful to CAM versus orthodox medicine: Part II--applications of Part I fundamentals to five different space-time examples.

PubMed

Tiller, William A

2010-04-01

In Part I of this pair of articles, the fundamental experimental observations and theoretical perspectives were provided for one to understand the key differences between our normal, uncoupled state of physical reality and the human consciousness-induced coupled state of physical reality. Here in Part II, the thermodynamics of complementary and alternative medicine, which deals with the partially coupled state of physical reality, is explored via the use of five different foci of relevance to today's science and medicine: (1) homeopathy; (2) the placebo effect; (3) long-range, room temperature, macroscopic size-scale, information entanglement; (4) an explanation for dark matter/energy plus human levitation possibility; and (5) electrodermal diagnostic devices. The purpose of this pair of articles is to clearly differentiate the use and limitations of uncoupled state physics in both nature and today's orthodox medicine from coupled state physics in tomorrow's complementary and alternative medicine.

An environment-dependent semi-empirical tight binding model suitable for electron transport in bulk metals, metal alloys, metallic interfaces, and metallic nanostructures. II. Application—Effect of quantum confinement and homogeneous strain on Cu conductance

NASA Astrophysics Data System (ADS)

Hegde, Ganesh; Povolotskyi, Michael; Kubis, Tillmann; Charles, James; Klimeck, Gerhard

2014-03-01

The Semi-Empirical tight binding model developed in Part I Hegde et al. [J. Appl. Phys. 115, 123703 (2014)] is applied to metal transport problems of current relevance in Part II. A systematic study of the effect of quantum confinement, transport orientation, and homogeneous strain on electronic transport properties of Cu is carried out. It is found that quantum confinement from bulk to nanowire boundary conditions leads to significant anisotropy in conductance of Cu along different transport orientations. Compressive homogeneous strain is found to reduce resistivity by increasing the density of conducting modes in Cu. The [110] transport orientation in Cu nanowires is found to be the most favorable for mitigating conductivity degradation since it shows least reduction in conductance with confinement and responds most favorably to compressive strain.

Nonperturbative vacuum polarization effects in two-dimensional supercritical Dirac-Coulomb system I. Vacuum charge density

NASA Astrophysics Data System (ADS)

Davydov, A.; Sveshnikov, K.; Voronina, Yu.

2018-01-01

Based on the original combination of analytical methods, computer algebra tools and numerical calculations, proposed recently in Refs. 1-3, the nonperturbative vacuum polarization effects in the 2+1D supercritical Dirac-Coulomb system with Z > Zcr,1 are explored. Both the vacuum charge density ρV P(r→) and vacuum energy ℰV P are considered. The main result of the work is that in the overcritical region ℰV P turns out to be a rapidly decreasing function ˜-ηeffZ3/R with ηeff > 0 and R being the size of the external Coulomb source. Due to a lot of details of calculation the whole work is divided into two parts I and II. In the present part I, we consider the evaluation and behavior of the vacuum density ρV P, which further is used in part II for evaluation of the vacuum energy, with emphasis on the renormalization, convergence of the partial expansion for ρV P and behavior of the integral induced charge QV P in the overcritical region.

Minority Recruiting in The New York City Police Department: Part I. The Attraction of Candidates, Part II. The Retention of Candidates.

ERIC Educational Resources Information Center

Hunt, Isaac C., Jr.; Cohen, Bernard

In an effort to increase the proportion of minority group members on the New York City police force, this study was commissioned: (1) to learn the reasons for present difficulties in minority recruitment, (2) to analyze the effectiveness of current recruiting strategies and programs, and (3) to develop new approaches aimed at improving minority…

Radio Frequency Identification (RFID) Based Corrosion Monitoring Sensors. Part 2: Application and Testing of the Coating Materials

DTIC Science & Technology

2014-12-22

Radio frequency identification ( RFID ) based corrosion monitoring sensors: Part II Application and testing of the coating materials Youliang He1...email: yohe@nrcan.gc.ca Keywords: Corrosion monitoring; Wireless sensor; RFID ; Electromagnetic interference; Coating. Abstract Cost-effective...Radio Frequency Identification ( RFID ) transponders (tags) were investigated for wireless corrosion monitoring by applying a metal-filled conductive

A Study of Mandarin Loanwords: Lexical Stratification, Adaptation and Factors

ERIC Educational Resources Information Center

Kim, Tae Eun

2012-01-01

This dissertation is about Chinese loanwords. It is mainly divided into two parts. Part I is a general discussion about loanwords in Chinese; Chapter I and II belong to the first part. Part II is a discussion about the analyses of Mandarin loanwords originating from English. Chapter III, IV, and V are all related to the second part. Chapter VI is…

Network Centric Operations (NCO) Case Study. The British Approach to Low-Intensity Operations: Part 2

DTIC Science & Technology

2007-02-12

Imperial War Museum Sound Archive, Accession No. 16397 (6 January 1996 ) 46 Jackson, p .45 47 Nagl, p .66-7 48 Stubbs, p .71 49 Nagl, p .93 Part II 16...Coogan, The Troubles, (London: Arrow, 1996 ), p .145 Part II 61 of 246 but there really appeared to be nothing in between to provide workable...Psychological Ops Capability Since 1945’, British Army Review, December 1996 , p .5 Part II 62 of 246 weakness caused by the lack of both numbers and

Adhesive Bonding Experiments for Titanium 6 Aluminum 4 Vanadium (Ti6Al4V). Part I. Anodization Treatments.

DTIC Science & Technology

1979-12-01

Identification of Surface Treat- 4 ments of Ti 6-4 II Effect of Increasing Oxide Porosity on H20 Contact Angle on Titanium 6 Aluminum 4 Vanadium 26 viii SECTIONI...and a high SIMS yield. The lithium does not appear in the oxide formed on titanium by this mixture. Similarly porosity may be induced by anodization at...Porous Oxide (B). 25 TABLE II EFFECT OF INCREASING OXIDE POROSITY ON H2 0 CONTACT ANGLE ON TITANIUM 6 ALUMINUM 4 VANADIUM - I H 2 0Sample Electrolyte

20 CFR 408.101 - What is this part about?

Code of Federal Regulations, 2011 CFR

2011-04-01

....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

20 CFR 408.101 - What is this part about?

Code of Federal Regulations, 2014 CFR

2014-04-01

....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

20 CFR 408.101 - What is this part about?

Code of Federal Regulations, 2013 CFR

2013-04-01

....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

20 CFR 408.101 - What is this part about?

Code of Federal Regulations, 2012 CFR

2012-04-01

....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

Weld pool development during GTA and laser beam welding of Type 304 stainless steel; Part II-experimental correlation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zacharia, T.; David, S.A.; Vitek, J.M.

1989-12-01

In part I of the paper, the results of the heat flow and the fluid flow analysis were presented. Here, in Part II of the paper, predictions of the computational model are verified by comparing the numerically predicted and experimentally observed fusion zone size and shape. Stationary gas tungsten arc and laser beam welds were made on Type 304 stainless steel for different times to provide a variety of solidification conditions such as cooling rate and temperature gradient. Calculated temperatures and cooling rates are correlated with the experimentally observed fusion zone structure. In addition, the effect of sulfur on GTAmore » weld penetration was quantitatively evaluated by considering two heats of 304 stainless steel containing 90 and 240 ppm sulfur. Sulfur, as expected, increased the depth/width ratio by altering the surface tension gradient driven flow in the weld pool.« less

Nonperturbative vacuum polarization effects in two-dimensional supercritical Dirac-Coulomb system II. Vacuum energy

NASA Astrophysics Data System (ADS)

Davydov, A.; Sveshnikov, K.; Voronina, Yu.

2018-01-01

Nonperturbative vacuum polarization effects are explored for a supercritical Dirac-Coulomb system with Z > Zcr,1 in 2+1D, based on the original combination of analytical methods, computer algebra and numerical calculations, proposed recently in Refs. 1-3. Both the vacuum charge density ρV P(r→) and vacuum energy ℰV P are considered. Due to a lot of details of calculation the whole work is divided into two parts I and II. Taking account of results, obtained in the part I4 for ρV P, in the present part II, the evaluation of the vacuum energy ℰV P is investigated with emphasis on the renormalization and convergence of the partial expansion for ℰV P. It is shown that the renormalization via fermionic loop turns out to be the universal tool, which removes the divergence of the theory both in the purely perturbative and essentially nonperturbative regimes of the vacuum polarization. The main result of calculation is that for a wide range of the system parameters in the overcritical region ℰV P turns out to be a rapidly decreasing function ˜-ηeffZ3/R with ηeff > 0 and R being the size of the external Coulomb source. To the end the similarity in calculations of ℰV P in 2+1 and 3+1D is discussed, and qualitative arguments are presented in favor of the possibility for complete screening of the classical electrostatic energy of the Coulomb source by the vacuum polarization effects for Z ≫ Zcr,1 in 3+1D.

12 CFR Appendix II to Part 27 - Information for Government Monitoring Purposes

Code of Federal Regulations, 2010 CFR

2010-01-01

... II Appendix II to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY... Monitoring Purposes The following language is approved by the Comptroller of the Currency and will satisfy... used separately. This information may also be provided orally by the applicant. The following...

40 CFR Appendix II to Part 86 - Temperature Schedules

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Temperature Schedules II Appendix II... to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

A DOS Primer for Librarians: Part II.

ERIC Educational Resources Information Center

Beecher, Henry

1990-01-01

Provides an introduction to DOS commands and strategies for the effective organization and use of hard disks. Functions discussed include the creation of directories and subdirectories, enhanced copying, the assignment of disk drives, and backing up the hard disk. (CLB)

25 CFR 547.1 - What is the purpose of this part?

Code of Federal Regulations, 2011 CFR

2011-04-01

... STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.1 What is the purpose of this part... other technologic aids in connection with the play of Class II games. This part establishes the minimum...

25 CFR 547.1 - What is the purpose of this part?

Code of Federal Regulations, 2010 CFR

2010-04-01

... STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.1 What is the purpose of this part... other technologic aids in connection with the play of Class II games. This part establishes the minimum...

25 CFR 547.1 - What is the purpose of this part?

Code of Federal Regulations, 2012 CFR

2012-04-01

... STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.1 What is the purpose of this part... other technologic aids in connection with the play of Class II games. This part establishes the minimum...

THE ONSET OF ELECTRICAL BREAKDOWN IN DUST LAYERS: II. EFFECTIVE DIELECTRIC CONSTANT AND LOCAL FIELD ENHANCEMENT

EPA Science Inventory

Part 1 of the work has shown that electrical breakdown in dust layers obeys Paschen's Law, but occurs at applied field values which appear too small to initiate the breakdown. In this paper the authors show how an effective dielectric constant characterizing the dust layer can be...

Reducing the Deficit: Spending and Revenue Options. A Report to the Senate and House Committees on the Budget - Part II

DTIC Science & Technology

1989-02-01

tax law usually take effect at the beginning of a calendar year. The excise and energy tax options, however, are assumed to take effect on October 1...this volume would take effect on October 1, 1989, the revenue options generally have an effective date of January 1, 1990, because changes in income

Guidelines for implementing automation in a hospital laboratory setting--part II.

PubMed

Rodriques, Sarina

2007-03-28

Laboratories entering into a discussion regarding automation of their facility have a number of key issues that need to be considered right away. What is the financial impact going to be? How do we know which processes we should automate and which ones we shouldn't? Which vendor is going to best align with the goals of our organization? Developing a thorough and robust plan at the start of the automation process is vital to the overall success of the project. It requires dedicated staff members who are willing to do the research, crunch the numbers, and present the data effectively. In Part II of this manuscript, issues such as cost analyses, business plans, and purchasing decisions are each covered thoroughly.

Medical Devices; General Hospital and Personal Use Devices; Classification of the Image Processing Device for Estimation of External Blood Loss. Final order.

PubMed

2017-12-20

The Food and Drug Administration (FDA or we) is classifying the image processing device for estimation of external blood loss into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the image processing device for estimation of external blood loss' classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

Quantum Social Science

NASA Astrophysics Data System (ADS)

Haven, Emmanuel; Khrennikov, Andrei

2013-01-01

Preface; Part I. Physics Concepts in Social Science? A Discussion: 1. Classical, statistical and quantum mechanics: all in one; 2. Econophysics: statistical physics and social science; 3. Quantum social science: a non-mathematical motivation; Part II. Mathematics and Physics Preliminaries: 4. Vector calculus and other mathematical preliminaries; 5. Basic elements of quantum mechanics; 6. Basic elements of Bohmian mechanics; Part III. Quantum Probabilistic Effects in Psychology: Basic Questions and Answers: 7. A brief overview; 8. Interference effects in psychology - an introduction; 9. A quantum-like model of decision making; Part IV. Other Quantum Probabilistic Effects in Economics, Finance and Brain Sciences: 10. Financial/economic theory in crisis; 11. Bohmian mechanics in finance and economics; 12. The Bohm-Vigier Model and path simulation; 13. Other applications to economic/financial theory; 14. The neurophysiological sources of quantum-like processing in the brain; Conclusion; Glossary; Index.

Some biodiversity points and suggestions for the Myanmar Protected Area System

Treesearch

Daniel H. Henning

2007-01-01

This paper is divided into a brief background section followed by Part I: Biodiversity Points, and Part II: Suggestions that are needed for the ecological integrity of actual and potential protected areas in Myanmar. Part I consists of general and Myanmar Biodiversity Considerations, and Part II consists of the following suggestions: (l) international financial and...

Planning and conducting meetings effectively, part I: planning a meeting.

PubMed

Harolds, Jay

2011-12-01

Meetings are held by leaders for many purposes, including conveying information, raising morale, asking for opinions, brain storming, making people part of the problem-solving process, building trust, getting to a consensus, and making decisions. However, many meetings waste time, some undermine the leader's power, and some decrease morale. Part I of this series of articles gives some tips on basic planning for decision-making meetings. Part II of this series of articles analyzes selected components of decision-making meetings. Part III of this series will be on how the chairperson keeps decision-making meetings on track to make them efficient and productive.

STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis.

PubMed

Chen, Lei; Zhao, Lin; Samanta, Anweshan; Mahmoudi, Seyed Morteza; Buehler, Tanner; Cantilena, Amy; Vincent, Robert J; Girgis, Magdy; Breeden, Joshua; Asante, Samuel; Xuan, Yu-Ting; Dawn, Buddhadeb

2017-01-01

Signal transducers and activators of transcription 3 (STAT3) is known to participate in various cardiovascular signal transduction pathways, including those responsible for cardiac hypertrophy and cytoprotection. However, the role of STAT3 signaling in cardiomyocyte autophagy remains unclear. We tested the hypothesis that Angiotensin II (Ang II)-induced cardiomyocyte hypertrophy is effected, at least in part, through STAT3-mediated inhibition of cellular autophagy. In H9c2 cells, Ang II treatment resulted in STAT3 activation and cellular hypertrophy in a dose-dependent manner. Ang II enhanced autophagy, albeit without impacting AMPKα/mTOR signaling or cellular ADP/ATP ratio. Pharmacologic inhibition of STAT3 with WP1066 suppressed Ang II-induced myocyte hypertrophy and mRNA expression of hypertrophy-related genes ANP and β-MHC. These molecular events were recapitulated in cells with STAT3 knockdown. Genetic or pharmacologic inhibition of STAT3 significantly increased myocyte ADP/ATP ratio and enhanced autophagy through AMPKα/mTOR signaling. Pharmacologic activation and inhibition of AMPKα attenuated and exaggerated, respectively, the effects of Ang II on ANP and β-MHC gene expression, while concomitant inhibition of STAT3 accentuated the inhibition of hypertrophy. Together, these data indicate that novel nongenomic effects of STAT3 influence myocyte energy status and modulate AMPKα/mTOR signaling and autophagy to balance the transcriptional hypertrophic response to Ang II stimulation. These findings may have significant relevance for various cardiovascular pathological processes mediated by Ang II signaling.

STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis

PubMed Central

Samanta, Anweshan; Mahmoudi, Seyed Morteza; Buehler, Tanner; Cantilena, Amy; Vincent, Robert J.; Girgis, Magdy; Breeden, Joshua; Asante, Samuel; Xuan, Yu-Ting

2017-01-01

Signal transducers and activators of transcription 3 (STAT3) is known to participate in various cardiovascular signal transduction pathways, including those responsible for cardiac hypertrophy and cytoprotection. However, the role of STAT3 signaling in cardiomyocyte autophagy remains unclear. We tested the hypothesis that Angiotensin II (Ang II)-induced cardiomyocyte hypertrophy is effected, at least in part, through STAT3-mediated inhibition of cellular autophagy. In H9c2 cells, Ang II treatment resulted in STAT3 activation and cellular hypertrophy in a dose-dependent manner. Ang II enhanced autophagy, albeit without impacting AMPKα/mTOR signaling or cellular ADP/ATP ratio. Pharmacologic inhibition of STAT3 with WP1066 suppressed Ang II-induced myocyte hypertrophy and mRNA expression of hypertrophy-related genes ANP and β-MHC. These molecular events were recapitulated in cells with STAT3 knockdown. Genetic or pharmacologic inhibition of STAT3 significantly increased myocyte ADP/ATP ratio and enhanced autophagy through AMPKα/mTOR signaling. Pharmacologic activation and inhibition of AMPKα attenuated and exaggerated, respectively, the effects of Ang II on ANP and β-MHC gene expression, while concomitant inhibition of STAT3 accentuated the inhibition of hypertrophy. Together, these data indicate that novel nongenomic effects of STAT3 influence myocyte energy status and modulate AMPKα/mTOR signaling and autophagy to balance the transcriptional hypertrophic response to Ang II stimulation. These findings may have significant relevance for various cardiovascular pathological processes mediated by Ang II signaling. PMID:28686615

40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

Music in the exercise domain: a review and synthesis (Part II)

PubMed Central

Karageorghis, Costas I.; Priest, David-Lee

2011-01-01

Since a 1997 review by Karageorghis and Terry, which highlighted the state of knowledge and methodological weaknesses, the number of studies investigating musical reactivity in relation to exercise has swelled considerably. In this two-part review paper, the development of conceptual approaches and mechanisms underlying the effects of music are explicated (Part I), followed by a critical review and synthesis of empirical work (spread over Parts I and II). Pre-task music has been shown to optimise arousal, facilitate task-relevant imagery and improve performance in simple motoric tasks. During repetitive, endurance-type activities, self-selected, motivational and stimulative music has been shown to enhance affect, reduce ratings of perceived exertion, improve energy efficiency and lead to increased work output. There is evidence to suggest that carefully selected music can promote ergogenic and psychological benefits during high-intensity exercise, although it appears to be ineffective in reducing perceptions of exertion beyond the anaerobic threshold. The effects of music appear to be at their most potent when it is used to accompany self-paced exercise or in externally valid conditions. When selected according to its motivational qualities, the positive impact of music on both psychological state and performance is magnified. Guidelines are provided for future research and exercise practitioners. PMID:22577473

Dissecting Diversity Part II

ERIC Educational Resources Information Center

Matthews, Frank

2005-01-01

This article presents "Dissecting Diversity, Part II," the conclusion of a wide-ranging two-part roundtable discussion on diversity in higher education. The participants were as follows: Lezli Baskerville, J.D., President and CEO of the National Association for Equal Opportunity (NAFEO); Dr. Gerald E. Gipp, Executive Director of the…

Recent Economic Perspectives on Political Economy, Part II*

PubMed Central

Dewan, Torun; Shepsle, Kenneth A.

2013-01-01

In recent years some of the best theoretical work on the political economy of political institutions and processes has begun surfacing outside the political science mainstream in high quality economics journals. This two-part paper surveys these contributions from a recent five-year period. In Part I, the focus is on elections, voting and information aggregation, followed by treatments of parties, candidates, and coalitions. In Part II, papers on economic performance and redistribution, constitutional design, and incentives, institutions, and the quality of political elites are discussed. Part II concludes with a discussion of the methodological bases common to economics and political science, the way economists have used political science research, and some new themes and arbitrage opportunities. PMID:23606754

Use of bovine catalase and manganese dioxide for elimination of hydrogen peroxide from partly oxidized aqueous solutions of aromatic molecules - Unexpected complications

NASA Astrophysics Data System (ADS)

Kovács, Krisztina; Sági, Gyuri; Takács, Erzsébet; Wojnárovits, László

2017-10-01

Being a toxic substance, hydrogen peroxide (H2O2) formed during application of advanced oxidation processes disturbs the biological assessment of the treated solutions. Therefore, its removal is necessary when the concentration exceeds the critical level relevant to the biological tests. In this study, H2O2 removal was tested using catalase enzyme or MnO2 as catalysts and the concentration changes were measured by the Cu(II)/phenanthroline method. MnO2 and Cu(II) were found to react not only with H2O2 but also with the partly oxidized intermediates formed in the hydroxyl radical induced degradation of aromatic antibiotic and pesticide compounds. Catalase proved to be a milder oxidant, it did not show significant effects on the composition of organic molecules. The Cu(II)/phenanthroline method gives the correct H2O2 concentration only in the absence of easily oxidizable compounds, e.g. certain phenol type molecules.

Simulation results of corkscrew motion in DARHT-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, K. D.; Ekdahl, C. A.; Chen, Y. J.

2003-01-01

DARHT-II, the second axis of the Dual-Axis Radiographic Hydrodynamics Test Facility, is being commissioned. DARHT-II is a linear induction accelerator producing 2-microsecond electron beam pulses at 20 MeV and 2 kA. These 2-microsecond pulses will be chopped into four short pulses to produce time resolved x-ray images. Radiographic application requires the DARHT-II beam to have excellent beam quality, and it is important to study various beam effects that may cause quality degradation of a DARHT-II beam. One of the beam dynamic effects under study is 'corkscrew' motion. For corkscrew motion, the beam centroid is deflected off axis due to misalignmentsmore » of the solenoid magnets. The deflection depends on the beam energy variation, which is expected to vary by {+-}0.5% during the 'flat-top' part of a beam pulse. Such chromatic aberration will result in broadening of beam spot size. In this paper, we will report simulation results of our study of corkscrew motion in DARHT-II. Sensitivities of beam spot size to various accelerator parameters and the strategy for minimizing corkscrew motion will be described. Measured magnet misalignment is used in the simulation.« less

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in large animals with or without FDA IND status.

PubMed

Singh, Vijay K; Garcia, Melissa; Seed, Thomas M

2017-09-01

The threat of a radiological/nuclear event is a critical concern for all government agencies involved in national security and public health preparedness. Countermeasures that are safe, easily administered, and effective at diminishing or eliminating adverse health effects to individuals and the overall public health impact of radiation exposure are urgently needed. Radiation countermeasures included in this three-part series have been classified under various subheadings based specifically on their developmental stages for United States Food and Drug Administration (FDA) approval. We have included FDA-approved agents for acute radiation syndrome (ARS) in part I. This is part II in which we have reviewed FDA-approved agents for limited indications, internalized radionuclides, emesis, late effects, radiomitigators available in the strategic national stockpile (SNS), agents with FDA investigational new drug (IND) status, and those with NHP efficacy data without FDA IND. Agents discussed in part III are those agents that have been peer reviewed, published, and have demonstrated significant survival benefits in animal models of ARS. Agents investigated in in vitro models only or studied in animal models without peer-reviewed publications have not been included. The dearth of FDA-approved radiation countermeasures has prompted intensified research for a new generation of radiation countermeasures. A number of promising radiation countermeasures are currently moving forward with continued support and effort by both governmental agencies and by publicly and privately held pharmaceutical companies. There is a limited number of countermeasures which are progressing well following the Animal Rule and may get approved in the near future, thus serving to close the gap of this critically important, unmet radiobiomedical need.

40 CFR Appendix B to Subpart II of... - Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density B Appendix B to Subpart II of Part 63 Protection of... Shipbuilding and Ship Repair (Surface Coating) Pt. 63, Subpt. II, App. B Appendix B to Subpart II of Part 63...

40 CFR Appendix B to Subpart II to... - Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density B Appendix B to Subpart II to Part 63 Protection of... Shipbuilding and Ship Repair (Surface Coating) Pt. 63, Subpt. II, App. B Appendix B to Subpart II to Part 63...

Medical Devices; Gastroenterology-Urology Devices; Classification of the Metallic Biliary Stent System for Benign Strictures. Final order.

PubMed

2016-07-13

The Food and Drug Administration (FDA) is classifying the metallic biliary stent system for benign strictures into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the metallic biliary stent system for benign strictures' classification. The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device.

Mammalian Toxicity of Munitions Compounds Phase III: Effects of Life-Time Exposure Part II: Trinitroglycerin

DTIC Science & Technology

1978-11-01

injuries due to fighting, which may be treated by isolation, clean- ing the wounds, and antibiotic therapy, systemic and local . ii B. Basic ProtocolI 1...column contained 100 ml of 5% sodium hydroxide. Rats were given feed and water ad libitum. At the end of 24 hr, the rats were anesthetized with ether...Furthermore, their fur was usually a dirty tan color. There were no obviously localized stainings, but the rough, matted appearance showed that this was

Unlearning Established Organizational Routines--Part II

ERIC Educational Resources Information Center

Fiol, C. Marlena; O'Connor, Edward J.

2017-01-01

Purpose: The purpose of Part II of this two-part paper is to uncover important differences in the nature of the three unlearning subprocesses, which call for different leadership interventions to motivate people to move through them. Design/methodology/approach: The paper draws on research in behavioral medicine and psychology to demonstrate that…

Epigenetics: Behavioral Influences on Gene Function, Part II--Molecular Mechanisms

ERIC Educational Resources Information Center

Ogren, Marilee P.; Lombroso, Paul J.

2008-01-01

A study presented on the effect of parenting on stress response and other behaviors show that animals exposed to a high degree of nurturing show a blunted response to stress. Molecular mechanisms responsible for these differences in the adult offspring as well as the molecular mechanisms by which epigenetic effects are propagated from one…

14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

Code of Federal Regulations, 2010 CFR

2010-01-01

... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

Code of Federal Regulations, 2013 CFR

2013-01-01

... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

Code of Federal Regulations, 2012 CFR

2012-01-01

... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

Code of Federal Regulations, 2014 CFR

2014-01-01

... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

Code of Federal Regulations, 2011 CFR

2011-01-01

... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

40 CFR Appendix B to Subpart A of... - Class II Controlled Substances a

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Class II Controlled Substances a B Appendix B to Subpart A of Part 82 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED..., Subpt. A, App. B Appendix B to Subpart A of Part 82—Class II Controlled Substances a Controlled...

40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Propulsion Marine... Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The following duty cycle applies for discrete-mode testing: E4 Mode No. Enginespeed 1 Torque(percent) 2...

40 CFR Appendix II to Part 1039 - Steady-State Duty Cycles

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Steady-State Duty Cycles II Appendix... Appendix II to Part 1039—Steady-State Duty Cycles (a) The following duty cycles apply for constant-speed engines: (1) The following duty cycle applies for discrete-mode testing: D2 mode number Engine speed...

Antinociceptive activity of Riparin II from Aniba riparia: Further elucidation of the possible mechanisms.

PubMed

Rodrigues de Carvalho, Alyne Mara; Vasconcelos, Leonardo Freire; Moura Rocha, Nayrton Flávio; Vasconcelos Rios, Emiliano Ricardo; Dias, Marília Leite; Maria de França Fonteles, Marta; Gaspar, Danielle Macêdo; Barbosa Filho, José Maria; Chavez Gutierrez, Stanley Juan; Florenço de Sousa, Francisca Cléa

2018-05-01

Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-α and IL-1β production and its histamine antagonism. The objective of this study was to evaluate the role of RipII in the pain process and the possible antinociceptive mechanisms involved, using classic models of nociception. Male Swiss mice were used in the assays. Determinate the acute toxicity according to the OECD 425 test guideline. The models used were the acetic acid-, formalin-, hot plate and glutamate-induced nociception. For evaluation of antinociceptive effect, the involvement of TRPV1, TRPA1, TRPM8, ASICS, Bradykinin, PKC and PKA were performed using the paw licking using agonists. The acute toxicity study did not detect any clinical signs or changes in behavior or mortality. RipII, administered orally (25 and 50 mg/kg) caused a reduction of nociception induced by acetic acid, formalin (on the second phase) and glutamate. In the investigation of antinociceptive mechanism, we used capsaicin (2.2 μg/paw), cinnamaldehyde (10 nmol/paw), menthol (1.2 μmol/paw), ASICS (2% acetic acid, pH 1.98) and bradykinin (10 μg/paw). The results showed that TRPV1, TRPA1, TRPM8, ASICS and bradykinin play a role in the antinociceptive effect of RipII. The results also showed that PKA is involved too. These data demonstrate that RipII has a low or not toxicity and produced an important antinociceptive effect through mechanisms that probably involve an interaction, at least in part, TRPV1, TRPA1, TRPM8, ASICS, bradykinin and PKA participate in the RipII's antinociceptive effect. Copyright © 2018 Elsevier B.V. All rights reserved.

The Effects of World War II on Economic and Health Outcomes across Europe.

PubMed

Kesternich, Iris; Siflinger, Bettina; Smith, James P; Winter, Joachim K

2014-03-01

We investigate long-run effects of World War II on socio-economic status and health of older individuals in Europe. We analyze data from SHARELIFE, a retrospective survey conducted as part of SHARE in Europe in 2009. SHARELIFE provides detailed data on events in childhood during and after the war for over 20,000 individuals in 13 European countries. We construct several measures of war exposure-experience of dispossession, persecution, combat in local areas, and hunger periods. Exposure to war and more importantly to individual-level shocks caused by the war significantly predicts economic and health outcomes at older ages.

The Effects of World War II on Economic and Health Outcomes across Europe

PubMed Central

Kesternich, Iris; Siflinger, Bettina; Smith, James P.; Winter, Joachim K.

2013-01-01

We investigate long-run effects of World War II on socio-economic status and health of older individuals in Europe. We analyze data from SHARELIFE, a retrospective survey conducted as part of SHARE in Europe in 2009. SHARELIFE provides detailed data on events in childhood during and after the war for over 20,000 individuals in 13 European countries. We construct several measures of war exposure—experience of dispossession, persecution, combat in local areas, and hunger periods. Exposure to war and more importantly to individual-level shocks caused by the war significantly predicts economic and health outcomes at older ages. PMID:24850973

Coordinator(a) de Servicios Clinicos. Parte I (Unidad I-IV). Parte II (Unidad V-VI). Guia. Documento de Trabajo (Clinical Services Coordinator. Part I. Units I-IV. Part II. Units V-VI. Guide. Working Document).

ERIC Educational Resources Information Center

Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

This guide is intended for instructing secondary students in the occupation of clinical services coordinator in a hospital. The first part contains four units on the following subjects: the occupation of clinical services coordinator; interpersonal relationships; ethical/legal aspects; and communications (telephone, intercom, and others). For each…

EFFECT OF INSTILLED COMBUSTION-DERIVED ENVIRONMENTAL PARTICLES IN SPONTANEOUSLY HYPERTENSIVE RATS. PART II: PULMONARY RESPONSES

EPA Science Inventory

Abstract
A consistent association between exposure to high concentrations of ambient particulate matter (PM) and excess cardiopulmonary-related morbidity and mortality has been observed in numerous epidemiological studies, across many different geographical locations. To elic...

Study of the Effect of Free-Stream Turbulence upon Disturbances in the Pre-Transitional Laminar Boundary Layer. Part I. Laminar Boundary Layer Distortion by Surface Roughness; Effect upon Stability. Part II.

DTIC Science & Technology

1982-04-01

Boundary Layer Near a Plate." NACA Rept. 562, 1936. 5) A. A. Hall and G. S. Hislop , "Experiments on the Transition of the Laminar Boundary Layer on a...Cylinder." Proc. 5th Inter. Congr. Appl. Math, 1938. 7) G. S. Hislop , "The Transition of a Laminar Boundary Layer in a Wind Tunnel." Ph.D. Thesis...Small Vertical Cylinder Attached to a Flat Plate", h Fa- Elul"s, Vol. 23, Part 1, pp. 221-223, Jan. 1980 . 9. A. Von Doenhoff and E. A. Horton, "A Low

Computer-Assisted Instruction in the Context of the Advanced Instructional System. Part II. Materials Development Procedures and System Evaluation.

DTIC Science & Technology

1980-03-01

authoring system which would provide a basis for the cost effective production of computer-assisted irstruction (CAI) materials, It addresses the definition...RESULTS- - ------------------- 58 CAI Materials Development Times - - - 5J CAI Module Instructional Effectiveness -------- -- 59 First-Pass Module...CONCLUSIONS AND RECOMMENDATIONS ------ --- -- -- 70 Effectiveness of the Authoring System and Suggestions for Further Development - ----- --- -- --- 70

Two-dimensional finite element heat transfer model of softwood. Part II, Macrostructural effects

Treesearch

Hongmei Gu; John F. Hunt

2006-01-01

A two-dimensional finite element model was used to study the effects of structural features on transient heat transfer in softwood lumber with various orientations. Transient core temperature was modeled for lumber samples “cut” from various locations within a simulated log. The effects of ring orientation, earlywood to latewood (E/L) ratio, and ring density were...

Working draft of the FDA GMP final rule (Part II).

PubMed

Donawa, M E

1995-11-01

Part I of this two-part series provided information on the proposed design control provisions of the US Food and Drug Administration's (FDA) working draft of the final rule for new good manufacturing practice regulations for medical devices. The final rule could be published in April or May 1996. It would be in force 180 days after the date of publication. Design control requirements may become effective some months later. This article describes recommended modifications of three provisions that have been intensely discussed during recent FDA-sponsored public meetings.

Child impulsiveness-inattention, early peer experiences, and the development of early onset conduct problems.

PubMed

Snyder, James; Prichard, Joy; Schrepferman, Lynn; Patrick, M Renee; Stoolmiller, Mike

2004-12-01

The conjoint influence of child impulsiveness-inattention (I/I) and peer relationships on growth trajectories of conduct problems was assessed in a community sample of 267 boys and girls. I/I reliably predicted teacher- and parent-reported conduct problems at kindergarten entry and growth in those problems over the next 2 years for boys and girls. The relation of boys' I/I to conduct problems was mediated, in part, by peer rejection and involvement in coercive exchanges with peers. The relation of girls' I/I to conduct problems was less clearly mediated by peer processes, but peer difficulties had additive effects. The impact of peer relationships on trajectories of conduct problems was apparent to parents as well as to teachers. Although I/I increments risk for early and persisting conduct problems in concert with poor peer relationships, it does so in complex and gender-specific ways.

Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow.

PubMed

Bateman, Marjorie E; Strong, Amy L; Hunter, Ryan S; Bratton, Melyssa R; Komati, Rajesh; Sridhar, Jayalakshmi; Riley, Kevin E; Wang, Guangdi; Hayes, Daniel J; Boue, Stephen M; Burow, Matthew E; Bunnell, Bruce A

2017-04-15

While current therapies for osteoporosis focus on reducing bone resorption, the development of therapies to regenerate bone may also be beneficial. Promising anabolic therapy candidates include phytoestrogens, such as daidzein, which effectively induce osteogenesis of adipose-derived stromal cells (ASCs) and bone marrow stromal cells (BMSCs). To investigate the effects of glyceollins, structural derivatives of daidzein, on osteogenesis of ASCs and BMSCs. Herein, the osteoinductive effects of glyceollin I and glyceollin II were assessed and compared to estradiol in ASCs and BMSCs. The mechanism by which glyceollin II induces osteogenesis was further examined. The ability of glyceollins to promote osteogenesis of ASCs and BMSCs was evaluated in adherent and scaffold cultures. Relative deposition of calcium was analyzed using Alizarin Red staining, Bichinchoninic acid Protein Assay, and Alamar Blue Assay. To further explore the mechanism by which glyceollin II exerts its osteoinductive effects, docking studies of glyceollin II, RNA isolation, cDNA synthesis, and quantitative RT-PCR (qPCR) were performed. In adherent cultures, ASCs and BMSCs treated with estradiol, glyceollin I, or glyceollin II demonstrated increased calcium deposition relative to vehicle-treated cells. During evaluation on PLGA scaffolds seeded with ASCs and BMSCs, glyceollin II was the most efficacious in inducing ASC and BMSC osteogenesis compared to estradiol and glyceollin I. Dose-response analysis in ASCs and BMSCs revealed that glyceollin II has the highest potency at 10nM in adherent cultures and 1µM in tissue scaffold cultures. At all doses, osteoinductive effects were attenuated by fulvestrant, suggesting that glyceollin II acts at least in part through estrogen receptor-mediated pathways to induce osteogenesis. Analysis of gene expression demonstrated that, similar to estradiol, glyceollin II induces upregulation of genes involved in osteogenic differentiation. The ability of glyceollin II to induce osteogenic differentiation in ASCs and BMSCs indicates that glyceollins hold the potential for the development of pharmacological interventions to improve clinical outcomes of patients with osteoporosis. Copyright © 2017 Elsevier GmbH. All rights reserved.

Multi-Component Diffusion with Application To Computational Aerothermodynamics

NASA Technical Reports Server (NTRS)

Sutton, Kenneth; Gnoffo, Peter A.

1998-01-01

The accuracy and complexity of solving multicomponent gaseous diffusion using the detailed multicomponent equations, the Stefan-Maxwell equations, and two commonly used approximate equations have been examined in a two part study. Part I examined the equations in a basic study with specified inputs in which the results are applicable for many applications. Part II addressed the application of the equations in the Langley Aerothermodynamic Upwind Relaxation Algorithm (LAURA) computational code for high-speed entries in Earth's atmosphere. The results showed that the presented iterative scheme for solving the Stefan-Maxwell equations is an accurate and effective method as compared with solutions of the detailed equations. In general, good accuracy with the approximate equations cannot be guaranteed for a species or all species in a multi-component mixture. 'Corrected' forms of the approximate equations that ensured the diffusion mass fluxes sum to zero, as required, were more accurate than the uncorrected forms. Good accuracy, as compared with the Stefan- Maxwell results, were obtained with the 'corrected' approximate equations in defining the heating rates for the three Earth entries considered in Part II.

Education as Experimentation: A Planned Variation Model. Volume IV-B: Effects of Follow Through Models. Volume IV-C: Appendices, Part I and Part II.

ERIC Educational Resources Information Center

Bock, Geoffrey; And Others

This segment of the national evaluation study of the Follow Through Planned Variation Model describes each of the 17 models represented in the study and reports the results of analyses of 4 years of student performance data for each model. First a purely descriptive synthesis of findings is presented for each model, with interpretation of the data…

Medical Devices; Immunology and Microbiology Devices; Classification of the Device To Detect and Identify Microbial Pathogen Nucleic Acids in Cerebrospinal Fluid. Final order.

PubMed

2017-10-20

The Food and Drug Administration (FDA or we) is classifying the device to detect and identify microbial pathogen nucleic acids in cerebrospinal fluid into class II (special controls). The special controls that will apply to the device type are identified in this order and will be part of the codified language for the device to detect and identify microbial pathogen nucleic acids in cerebrospinal fluid’s classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

Evaluation of estimated energy conservation measure costs and benefits in the residential multifamily sector

NASA Astrophysics Data System (ADS)

1982-09-01

Supporting data for a policy review to determine how the multifamily buildings subsector is responding to market signals was sought. What role, if any, the federal government should play in encouraging conservation in multifamily buildings is discussed. The policy review seeks to develop an understanding of the current level of and trends in energy conservation activity in multifamily housing. The availability of the required data is determined and information in a form which facilitates its use by policy analysts is compiled. The results are presented in four parts. Part I provides an overview. Part II presents, in tabular form, the cost of selected retrofit items and the resulting energy and cost savings. As an aid to understanding the data in Part II, the salient assumptions underlying the data are also included in this part. Part III describes how the data in Part II were developed.

40 CFR Table II-1 to Subpart II of... - Emission Factors

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table II-1...

40 CFR Table II-1 to Subpart II of... - Emission Factors

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table II-1...

Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats.

PubMed

Sato, Akira; Yokoyama, Izumi; Ebina, Keiichi

2015-11-01

Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in many inflammatory diseases. In this study, we investigated the effects of Ang peptides (AngII, AngIII, and AngIV) on PAF-induced inflammatory activity. In experiments using a rat hind-paw oedema model, AngII markedly and dose-dependently attenuated the paw oedema induced by PAF. The inhibitory effects of AngIII and AngIV on PAF-induced paw oedema were lower than that of AngII. Two Ang receptors, the AT1 and AT2 receptors, did not affect the AngII-mediated attenuation of PAF-induced paw oedema. Moreover, intrinsic tyrosine fluorescence studies demonstrated that AngII, AngIII, and AngIV interact with PAF, and that their affinities were closely correlated with their inhibitory effects on PAF-induced rat paw oedema. Also, AngII interacted with metabolite/precursor of PAF (lyso-PAF), and an oxidized phospholipid, 1-palmitoyl-2-(5'-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC), which bears a marked structural resemblance to PAF. Furthermore, POVPC dose-dependently inhibited AngII-mediated attenuation of PAF-induced paw oedema. These results suggest that Ang peptides can attenuate PAF-induced inflammatory activity through binding to PAF and lyso-PAF in rats. Therefore, Ang peptides may be closely involved in the regulation of many inflammatory diseases caused by PAF. Copyright © 2015 Elsevier Inc. All rights reserved.

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Part D plan in writing 90 days before the intended date of the termination. (ii) The Part D plan... sponsor; (B) The Part D plan sponsor experiences financial difficulties so severe that its ability to make...)(4) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

5 CFR 330.602 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... equivalent) or below who: (i) Received a reduction in force (RIF) separation notice under part 351 of this... positions; and (ii) Received a RIF separation notice under part 351 of this chapter or a notice of proposed...); or (ii) Received a RIF notice of separation under part 351 of this chapter or a notice of proposed...

5 CFR 330.602 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... equivalent) or below who: (i) Received a reduction in force (RIF) separation notice under part 351 of this... positions; and (ii) Received a RIF separation notice under part 351 of this chapter or a notice of proposed...); or (ii) Received a RIF notice of separation under part 351 of this chapter or a notice of proposed...

5 CFR 330.602 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... equivalent) or below who: (i) Received a reduction in force (RIF) separation notice under part 351 of this... positions; and (ii) Received a RIF separation notice under part 351 of this chapter or a notice of proposed...); or (ii) Received a RIF notice of separation under part 351 of this chapter or a notice of proposed...

Market Analysis and Consumer Impacts Source Document. Part II. Review of Motor Vehicle Market and Consumer Expenditures on Motor Vehicle Transportation

DOT National Transportation Integrated Search

1980-12-01

This source document on motor vehicle market analysis and consumer impacts consists of three parts. Part II consists of studies and review on: motor vehicle sales trends; motor vehicle fleet life and fleet composition; car buying patterns of the busi...

Calculus of Elementary Functions, Part II. Teacher's Commentary. Revised Edition.

ERIC Educational Resources Information Center

Herriot, Sarah T.; And Others

This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This teacher's guide is for Part II of the course. It is designed to follow Part I of the text. The guide contains background information, suggested instructional…

Calculus of Elementary Functions, Part II. Student Text. Revised Edition.

ERIC Educational Resources Information Center

Herriot, Sarah T.; And Others

This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This text, Part II, contains material designed to follow Part I. Chapters included in this text are: (6) Derivatives of Exponential and Related Functions; (7) Area and…

The year 2012 in the European Heart Journal-Cardiovascular Imaging. Part II.

PubMed

Plein, Sven; Knuuti, Juhani; Edvardsen, Thor; Saraste, Antti; Piérard, Luc A; Maurer, Gerald; Lancellotti, Patrizio

2013-07-01

The part II of the best of the European Heart Journal - Cardiovascular Imaging in 2012 specifically focuses on studies of valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases.

Remote monitoring of fatigue-sensitive details on bridges : [part I and II].

DOT National Transportation Integrated Search

2015-03-01

Fatigue is one of the most critical problems for steel bridges as well as for any steel structures that needs : to be considered during design and operation. The objectives of this study are to explore monitoring : technologies, and to develop effect...

Reproduction in the space environment: Part II. Concerns for human reproduction

NASA Technical Reports Server (NTRS)

Jennings, R. T.; Santy, P. A.

1990-01-01

Long-duration space flight and eventual colonization of our solar system will require successful control of reproductive function and a thorough understanding of factors unique to space flight and their impact on gynecologic and obstetric parameters. Part II of this paper examines the specific environmental factors associated with space flight and the implications for human reproduction. Space environmental hazards discussed include radiation, alteration in atmospheric pressure and breathing gas partial pressures, prolonged toxicological exposure, and microgravity. The effects of countermeasures necessary to reduce cardiovascular deconditioning, calcium loss, muscle wasting, and neurovestibular problems are also considered. In addition, the impact of microgravity on male fertility and gamete quality is explored. Due to current constraints, human pregnancy is now contraindicated for space flight. However, a program to explore effective countermeasures to current constraints and develop the required health care delivery capability for extended-duration space flight is suggested. A program of Earth- and space-based research to provide further answers to reproductive questions is suggested.

Methods of Responsibly Managing End-of-Life Foams and Plastics Containing Flame Retardants: Part II.

PubMed

Lucas, Donald; Petty, Sara M; Keen, Olya; Luedeka, Bob; Schlummer, Martin; Weber, Roland; Yazdani, Ramin; Riise, Brian; Rhodes, James; Nightingale, Dave; Diamond, Miriam L; Vijgen, John; Lindeman, Avery; Blum, Arlene; Koshland, Catherine P

2018-06-01

This is Part II of a review covering the wide range of issues associated with all aspects of the use and responsible disposal of foam and plastic wastes containing toxic or potentially toxic flame retardants. We identify basic and applied research needs in the areas of responsible collection, pretreatment, processing, and management of these wastes. In Part II, we explore alternative technologies for the management of halogenated flame retardant (HFR) containing wastes, including chemical, mechanical, and thermal processes for recycling, treatment, and disposal.

Caring communications: how technology enhances interpersonal relations, Part II.

PubMed

Simpson, Roy L

2008-01-01

Part I of this 2-part series about technology's role in interpersonal communications examined how humans interact; proposed a caring theory of communication, collaboration, and conflict resolution; and delineated ways that technology--in general--supports this carative model of interpersonal relations. Part II will examine the barriers to adoption of carative technologies, describe the core capabilities required to overcome them, and discuss specific technologies that can support carative interpersonal relationships.

Joint stability characteristics of the ankle complex in female athletes with histories of lateral ankle sprain, part II: clinical experience using arthrometric measurement.

PubMed

Kovaleski, John E; Heitman, Robert J; Gurchiek, Larry R; Hollis, J M; Liu, Wei; Pearsall, Albert W

2014-01-01

This is part II of a 2-part series discussing stability characteristics of the ankle complex. In part I, we used a cadaver model to examine the effects of sectioning the lateral ankle ligaments on anterior and inversion motion and stiffness of the ankle complex. In part II, we wanted to build on and apply these findings to the clinical assessment of ankle-complex motion and stiffness in a group of athletes with a history of unilateral ankle sprain. To examine ankle-complex motion and stiffness in a group of athletes with reported history of lateral ankle sprain. Cross-sectional study. University research laboratory. Twenty-five female college athletes (age = 19.4 ± 1.4 years, height = 170.2 ± 7.4 cm, mass = 67.3 ± 10.0 kg) with histories of unilateral ankle sprain. All ankles underwent loading with an ankle arthrometer. Ankles were tested bilaterally. The dependent variables were anterior displacement, anterior end-range stiffness, inversion rotation, and inversion end-range stiffness. Anterior displacement of the ankle complex did not differ between the uninjured and sprained ankles (P = .37), whereas ankle-complex rotation was greater for the sprained ankles (P = .03). The sprained ankles had less anterior and inversion end-range stiffness than the uninjured ankles (P < .01). Changes in ankle-complex laxity and end-range stiffness were detected in ankles with histories of sprain. These results indicate the presence of altered mechanical characteristics in the soft tissues of the sprained ankles.

Hospital reimbursement incentives: is there a more effective option?--Part II.

PubMed

Weil, Thomas P

2013-01-01

As discussed in Part I of this article, hospital executives in Canada, Germany, and the United States manage their facilities' resources to maximize the incentives inherent in their respective reimbursement system and thereby increase their bottom line. It was also discussed that an additional supply of available hospitals, physicians, and other services will generate increased utilization. Part II discusses how the Patient Protection and Affordable Care Act of 2010 will eventually fail since it neither controls prices nor utilization (e.g., imaging, procedures, ambulatory surgery, discretionary spending). This article concludes with the discussion of the German multipayer approach with universal access and global budgets that might well be a model for U.S. healthcare in the future. Although the German healthcare system has a number of shortfalls, its paradigm could offer the most appropriate compromise when selecting the economic incentives to reduce the percentage of the U.S. gross domestic product expenditure for healthcare from 17.4% to roughly 12.0%.

REPORT OF THE EFFECTIVENESS OF PROJECT HEAD START, LUBBOCK, TEXAS. PARTS I, II, AND APPENDICES.

ERIC Educational Resources Information Center

CARTWRIGHT, WALTER J.; STEGLICH, W.G.

WITH THE COMPLETION OF THE FIRST GRADE BY THE FIRST HEAD START CLASS IN LUBBOCK, TEXAS, THIS STUDY WAS UNDERTAKEN TO PRESENT DATA ON THE EFFECTIVENESS OF THE HEAD START PROGRAM IN IMPROVING DISADVANTAGED CHILDREN'S CHANCES FOR SCHOOL SUCCESS. TWO HUNDRED AND NINETY-FIVE URBAN AREA HEAD START CHILDREN FROM NEGRO, ANGLO-AMERICAN, AND…

Kick, Glide, Pole! Cross-Country Skiing Fun (Part II)

ERIC Educational Resources Information Center

Duoos, Bridget A.

2012-01-01

Part I of Kick, Glide, Pole! Cross-Country Skiing Fun, which was published in last issue, discussed how to select cross-country ski equipment, dress for the activity and the biomechanics of the diagonal stride. Part II focuses on teaching the diagonal stride technique and begins with a progression of indoor activities. Incorporating this fun,…

An Occupation and Participation Approach to Reading Intervention (OPARI) Part II: Pilot Clinical Application

ERIC Educational Resources Information Center

Grajo, Lenin C.; Candler, Catherine

2016-01-01

The Occupation and Participation Approach to Reading Intervention (OPARI) is an intervention approach for children with reading difficulties that emphasizes reading as an important occupation of children. Part I presented the theoretical basis of the OPARI. Part II describes a pilot clinical application of the OPARI. Guided by Schkade and…

Workshop on effects management on forest soil carbon: A report. Held in Fort Collins, Colorado on December 5-7, 1994. Forest Service general technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frey, S.D.

1996-03-01

The Health Effects Institute`s (HEI) Diesel Working Group recently completed an evaluation of the carcinogenic risks associated with exposure to diesel engine emission. Part I of this report, `Critical Issues In Assessing the Carcinogenicity of Diesel Exhaust: A Synthesis of Current Knowledge,` by Kathleen M. Nauss and the HEI Diesel Working Group presents the consensus views of the Group. Part II contains four background papers that address emissions and exposure issues and five papers that consider biological responses.

Copper and the oxidation of hemoglobin: a comparison of horse and human hemoglobins.

PubMed

Rifkind, J M; Lauer, L D; Chiang, S C; Li, N C

1976-11-30

Oxidation studies of hemoglobin by Cu(II) indicate that for horse hemoglobin, up to a Cu(II)/heme molar ratio of 0.5, all of the Cu(II) added is used to rapidly oxidize the heme. On the other hand, most of the Cu(II) added to human hemoglobin at low Cu(II)/heme molar ratios is unable to oxidize the heme. Only at Cu(II)/heme molar ratios greater than 0.5 does the amount of oxidation per added Cu(II) approach that of horse hemoglobin. At the same time, binding studies indicate that human hemoglobin has an additional binding site involving one copper for every two hemes, which has a higher copper affinity than the single horse hemoglobin binding site. The Cu(II) oxidation of human hemoglobin is explained utilizing this additional binding site by a mechanism where a transfer of electrons cannot occur between the heme and the Cu(II) bound to the high affinity human binding site. The electron transfer must involve the Cu(II) bound to the lower affinity human hemoglobin binding site, which is similar to the only horse hemoglobin site. The involvement of beta-2 histidine in the binding of this additional copper is indicated by a comparison of the amino acid sequences of various hemoglobins which possess the additional site, with the amino acid sequences of hemoglobins which do not possess the additional site. Zn(II), Hg(II), and N-ethylmaleimide (NEM) are found to decrease the Cu(II) oxidation of hemoglobin. The sulfhydryl reagents, Hg(II) and NEM, produce a very dramatic decrease in the rate of oxidation, which can only be explained by an effect on the rate for the actual transfer of electrons between the Cu(II) and the Fe(II). The effect of Zn(II) is much smaller and can, for the most part, be explained by the increased oxygen affinity, which affects the ligand dissociation process that must precede the electron transfer process.

42 CFR 423.120 - Access to covered Part D drugs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... pharmacists. (ii) Includes at least one practicing physician and at least one practicing pharmacist who are... manufacturers. (iii) Includes at least one practicing physician and one practicing pharmacist who are experts...)), authorized prescribers, network pharmacies, and pharmacists prior to the date such change becomes effective...

Who Should Get in? Part II.

ERIC Educational Resources Information Center

Jencks, Christopher

2001-01-01

Reviews eight books on immigration, examining the effect of the widening wage gap between immigrant and native workers and discussing why some might want to limit the total number of immigrants. Books describe second generation immigrants; Latinos' experiences; immigration policy and the economy; black identities; immigration's economic,…

HISTORY OF EMPLOYMENT AND MANPOWER POLICY IN THE UNITED STATES. PARTS I AND II, DEPRESSION EXPERIENCE, PROPOSALS, AND PROGRAMS. SELECTED READINGS IN EMPLOYMENT AND MANPOWER, VOLUME 5.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

THE SELECTED READINGS WERE COMPILED TO PROVIDE SUBCOMMITTEE MEMBERS WITH A BROAD BACKGROUND OF DEVELOPMENTS LEADING TO THE EMPLOYMENT ACT OF 1946 AND WITH APPRAISALS OF ITS ADEQUACY AND EFFECTIVENESS. MATERIAL IN THIS VOLUME SPANS THE LATE 1920'S AND THE GREAT DEPRESSION. PARTS III AND IV (VT 004 820) CONTINUE THE HISTORICAL BACKGROUND AND REVIEW.…

Characterization of low-temperature properties of plant-produced rap mixtures in the Northeast

NASA Astrophysics Data System (ADS)

Medeiros, Marcelo S., Junior

The dissertation outlined herein results from a Federal Highway Administration sponsored project intended to investigate the impacts of high percentages of RAP material in the performance of pavements under cold climate conditions. It is comprised of two main sections that were incorporated into the body of this dissertation as Part I and Part II. In Part I a reduced testing framework for analysis of HMA mixes was proposed to replace the IDT creep compliance and strength testing by dynamic modulus and fatigue tests performed on an AMPT device. A continuum damage model that incorporates the nonlinear constitutive behavior of the HMA mixtures was also successfully implemented and validated. Mixtures with varying percentages of reclaimed material (RAP) ranging from 0 to 40% were used in this research effort in order to verify the applicability of the proposed methodology to RAP mixtures. Part II is concerned with evaluating the effects of various binder grades on the properties of plant-produced mixtures with various percentages of RAP. The effects of RAP on mechanical and rheological properties of mixtures and extracted binders were studied in order to identify some of the deficiencies in the current production methodologies. The results of this dissertation will help practitioners to identify optimal RAP usage from a material property perspective. It also establishes some guidelines and best practices for the use of higher RAP percentages in HMA.

Corporate liability: security and violence--Part II.

PubMed

Fiesta, J

1996-04-01

A hospital can be held liable for injuries resulting from failure to provide adequate, reasonable security Part II of "corporate Liability: Security and Violence" addresses negligent hiring and supervision practices, injury and domestic violence in the workplace and communication procedures.

The Many Faces of Part-List Cuing—Evidence for the Interplay Between Detrimental and Beneficial Mechanisms

PubMed Central

Lehmer, Eva-Maria; Bäuml, Karl-Heinz T.

2018-01-01

If participants study a list of items and, at test, receive a random selection of the studied items as retrieval cues, then such cuing often impairs recall of the remaining items. This effect, referred to as part-list cuing impairment, is a well-established finding in memory research that, over the years, has been attributed to quite different cognitive mechanisms. Here, we provide a review of more recent developments in research on part-list cuing. These developments (i) suggest a new view on part-list cuing impairment and a critical role of encoding for the effect, (ii) identify conditions in which part-list cuing impairment can turn into part-list cuing facilitation, and (iii) relate research on part-list cuing to a phenomenon from social memory, known as collaborative inhibition. The recent developments also include a new multi-mechanisms account, which attributes the effects of cuing to the interplay between detrimental mechanisms—like blocking, inhibition, or strategy disruption—and beneficial mechanisms—like context reactivation. The account provides a useful theoretical framework to describe both older and newer findings. It may guide future work on part-list cuing and may also motivate new research on collaborative inhibition. PMID:29867667

Medical Devices; General Hospital and Personal Use Devices; Classification of the Ultraviolet Radiation Chamber Disinfection Device. Final order.

PubMed

2015-11-20

The Food and Drug Administration (FDA or the Agency) is classifying the ultraviolet (UV) radiation chamber disinfection device into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the UV radiation chamber disinfection device classification. The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device.

Medical Devices; Immunology and Microbiology Devices; Classification of the Assayed Quality Control Material for Clinical Microbiology Assays. Final order.

PubMed

2017-07-27

The Food and Drug Administration (FDA, Agency, or we) is classifying the assayed quality control material for clinical microbiology assays into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the assayed quality control material for clinical microbiology assays' classification. The Agency is classifying the device into class II (special controls) to provide a reasonable assurance of safety and effectiveness of the device.

Mammalian Toxicity of Munitions Compounds. Phase II. Effects of Multiple Doses Part II. 2,4-Dinitrotoluene

DTIC Science & Technology

1978-11-01

middle, or high levels of 2,4-DNT in the feed averaged 34, 93, or 266 mg/kg/day, respectively. The female rats consumed an average of 38, 108, or 145 mg...intake of males fed the low, middle or high levels of 2,4-DNT in the feed averaged 47, 137, or 413 mg/kg/day, respectively. The female mice consumed an...Experimental Procedures All dogs were observed daily for behavioral changes and toxic signs. Body weights of all dogs were recorded weekly. Blood

Sporting Goods. Part I: Hunting and Fishing Equipment and Part II: Athletic, Marine, and Camping Equipment. A Distributive Education Manual.

ERIC Educational Resources Information Center

Day, Bill D., Comp.

These manuals were prepared to introduce students to the fundamentals of hunting and fishing (Part I) and sports requiring athletic, marine and camping equipment (Part II). The sports salesman is in the position of offering a service to the customer, and he can best do so by understanding the sports and the variety of products which may be sold to…

Interactive Macroeconomics

NASA Astrophysics Data System (ADS)

Di Guilmi, Corrado; Gallegati, Mauro; Landini, Simone

2017-04-01

Preface; List of tables; List of figures, 1. Introduction; Part I. Methodological Notes and Tools: 2. The state space notion; 3. The master equation; Part II. Applications to HIA Based Models: 4. Financial fragility and macroeconomic dynamics I: heterogeneity and interaction; 5. Financial fragility and macroeconomic Dynamics II: learning; Part III. Conclusions: 6. Conclusive remarks; Part IV. Appendices and Complements: Appendix A: Complements to Chapter 3; Appendix B: Solving the ME to solve the ABM; Appendix C: Specifying transition rates; Index.

Design of two-dimensional channels with prescribed velocity distributions along the channel walls

NASA Technical Reports Server (NTRS)

Stanitz, John D

1953-01-01

A general method of design is developed for two-dimensional unbranched channels with prescribed velocities as a function of arc length along the channel walls. The method is developed for both compressible and incompressible, irrotational, nonviscous flow and applies to the design of elbows, diffusers, nozzles, and so forth. In part I solutions are obtained by relaxation methods; in part II solutions are obtained by a Green's function. Five numerical examples are given in part I including three elbow designs with the same prescribed velocity as a function of arc length along the channel walls but with incompressible, linearized compressible, and compressible flow. One numerical example is presented in part II for an accelerating elbow with linearized compressible flow, and the time required for the solution by a Green's function in part II was considerably less than the time required for the same solution by relaxation methods in part I.

Inhibitory Effects of Low Decibel Infrasound on the Cardiac Fibroblasts and the Involved Mechanism

PubMed Central

Jin, Wei; Deng, Qin-Qin; Chen, Bao-Ying; Lu, Zhen-Xing; Li, Qing; Zhao, Hai-Kang; Chang, Pan; Yu, Jun; Pei, Zhao-Hui

2017-01-01

Introduction: Infrasound is a mechanical vibration wave with frequency between 0.0001 and 20 Hz. It has been established that infrasound of 120 dB or stronger is dangerous to humans. However, the biological effects of low decibel infrasound are largely unknown. The purpose of this study was to investigate the effects of low decibel infrasound on the cardiac fibroblasts. Materials and Methods: The cardiac fibroblasts were isolated and cultured from Sprague–Dawley rats. The cultured cells were assigned into the following four groups: control group, angiotensin II (Ang II) group, infrasound group, and Ang II+infrasound group. The cell proliferation and collagen synthesis rates were evaluated by means of [3H]-thymidine and [3H]-proline incorporation, respectively. The levels of TGF-β were determined by enzyme-linked immunosorbent assay. Moreover, RNAi approaches were used for the analysis of the biological functions of miR-29a, and the phosphorylation status of Smad3 was detected using western blotting analysis. Results: The results showed that low decibel infrasound significantly alleviated Ang II-induced enhancement of cell proliferation and collagen synthesis. Discussion: Compared with the control, Ang II markedly decreased the expression of miR-29a levels and increased the secretion of TGF-β and phosphorylation of Smad3, which was partly reversed by the treatment with low decibel infrasound. Importantly, knockdown of miR-29a diminished the effects of infrasound on the cardiac fibroblasts. In conclusion, low decibel infrasound inhibits Ang II-stimulated cardiac fibroblasts via miR-29a targeting TGF-β/Smad3 signaling. PMID:28615545

Inhibitory effects of low decibel infrasound on the cardiac fibroblasts and the involved mechanism.

PubMed

Jin, Wei; Deng, Qin-Qin; Chen, Bao-Ying; Lu, Zhen-Xing; Li, Qing; Zhao, Hai-Kang; Chang, Pan; Yu, Jun; Pei, Zhao-Hui

2017-01-01

Infrasound is a mechanical vibration wave with frequency between 0.0001 and 20 Hz. It has been established that infrasound of 120 dB or stronger is dangerous to humans. However, the biological effects of low decibel infrasound are largely unknown. The purpose of this study was to investigate the effects of low decibel infrasound on the cardiac fibroblasts. The cardiac fibroblasts were isolated and cultured from Sprague-Dawley rats. The cultured cells were assigned into the following four groups: control group, angiotensin II (Ang II) group, infrasound group, and Ang II+infrasound group. The cell proliferation and collagen synthesis rates were evaluated by means of [3H]-thymidine and [3H]-proline incorporation, respectively. The levels of TGF-β were determined by enzyme-linked immunosorbent assay. Moreover, RNAi approaches were used for the analysis of the biological functions of miR-29a, and the phosphorylation status of Smad3 was detected using western blotting analysis. The results showed that low decibel infrasound significantly alleviated Ang II-induced enhancement of cell proliferation and collagen synthesis. Compared with the control, Ang II markedly decreased the expression of miR-29a levels and increased the secretion of TGF-β and phosphorylation of Smad3, which was partly reversed by the treatment with low decibel infrasound. Importantly, knockdown of miR-29a diminished the effects of infrasound on the cardiac fibroblasts. In conclusion, low decibel infrasound inhibits Ang II-stimulated cardiac fibroblasts via miR-29a targeting TGF-β/Smad3 signaling.

Angiotensin II attenuates NMDA receptor-mediated neuronal cell death and prevents the associated reduction in Bcl-2 expression.

PubMed

Schelman, William R; Andres, Robert; Ferguson, Paul; Orr, Brent; Kang, Evan; Weyhenmeyer, James A

2004-09-10

While angiotensin II (Ang II) plays a major role in the regulation of blood pressure, fluid homeostasis and neuroendocrine function, recent studies have also implicated the peptide hormone in cell growth, differentiation and apoptosis. In support of this, we have previously demonstrated that Ang II attenuates N-methyl-D-aspartate (NMDA) receptor signaling [Molec. Brain Res. 48 (1997) 197]. To further examine the modulatory role of Ang II on NMDA receptor function, we investigated the effect of angiotensin receptor (AT) activation on NMDA-mediated cell death and the accompanying decrease in Bcl-2 expression. The viability of differentiated N1E-115 and NG108-15 neuronal cell lines was reduced following exposure to NMDA in a dose-dependent manner. MTT analysis (mitochondrial integrity) revealed a decrease in cell survival of 49.4+/-12.3% in NG108 cells and 79.9+/-6.8% in N1E cells following treatment with 10 mM NMDA for 20 h. Cytotoxicity in N1E cells was inhibited by the noncompetitive NMDA receptor antagonist, MK-801. Further, NMDA receptor-mediated cell death in NG108 cells was attenuated by treatment with Ang II. The Ang II effect was inhibited by both AT1 and AT2 receptor antagonists, losartan and PD123319, respectively, suggesting that both receptor subtypes may play a role in the survival effect of Ang II. Since it has been shown that activation of NMDA receptors alters the expression of Bcl-2 family proteins, Western blot analysis was performed in N1E cells to determine whether Ang II alters the NMDA-induced changes in Bcl-2 expression. A concentration-dependent decrease of intracellular Bcl-2 protein levels was observed following treatment with NMDA, and this reduction was inhibited by MK801. Addition of Ang II suppressed the NMDA receptor-mediated reduction in Bcl-2. The Ang II effect on NMDA-mediated changes in Bcl-2 levels was blocked by PD123319, but was not significantly changed by losartan, suggesting AT2 receptor specificity. Taken together, these results suggest that Ang II attenuates NMDA receptor-mediated neurotoxicity and that this effect may be due, in part, to an alteration in Bcl-2 expression.

40 CFR Appendix II to Part 257 - Appendix II to Part 257

Code of Federal Regulations, 2014 CFR

2014-07-01

... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

40 CFR Appendix II to Part 257 - Appendix II to Part 257

Code of Federal Regulations, 2010 CFR

2010-07-01

... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

40 CFR Appendix II to Part 257 - Appendix II to Part 257

Code of Federal Regulations, 2011 CFR

2011-07-01

... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

40 CFR Appendix II to Part 257 - Appendix II to Part 257

Code of Federal Regulations, 2012 CFR

2012-07-01

... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

40 CFR Appendix II to Part 257 - Appendix II to Part 257

Code of Federal Regulations, 2013 CFR

2013-07-01

... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

Higher Education in Poland Part II: Rules of Admissions, Student Activities, and Curriculums. Bulletin, 1964, No. 22. OE-14099

ERIC Educational Resources Information Center

Rosen, Seymour M.; Apanasewicz, Nellie

1964-01-01

The previously published "Higher Education in Poland, Part I: Organization and Administration," and the present volume constitute an Office of Education study on the Polish system of higher learning. Part II explains the functioning of Polish institutions under control of the Ministry of Higher Education and other ministries, and…

The Mental Health Recovery Movement and Family Therapy, Part II: A Collaborative, Appreciative Approach for Supporting Mental Health Recovery

ERIC Educational Resources Information Center

Gehart, Diane R.

2012-01-01

A continuation of Part I, which introduced mental health recovery concepts to family therapists, Part II of this article outlines a collaborative, appreciative approach for working in recovery-oriented contexts. This approach draws primarily upon postmodern therapies, which have numerous social justice and strength-based practices that are easily…

Institutional Self-Analysis and Long-Range Planning in a Small Liberal Arts College. Part II-- Study Procedure.

ERIC Educational Resources Information Center

Frame, Stanley M.

In the Spring of 1969, Bethany Nazarene College started an intensive self evaluation effort, called the Ten-Year Advance Study. Part I of the report, the Study Design, was published in October 1969. This study, Part II, relates the study activities, the methodology, and sources consulted. The effort involved over 120 administrators, faculty,…

Learning To Read with Private Pete & Sailor Sam in World War II.

ERIC Educational Resources Information Center

Sticht, Thomas G.

Since thousands of the men who entered military service during World War II were illiterate, the Army developed an "Army Reader," a four-part series featuring Private Pete, that led learners through literacy levels 1-4. Part 1 introduced Private Pete and talked about the things the men experienced when they entered the Army. Part 2…

Effects of using two- versus three-dimensional computational modeling of fluidized beds Part I, hydrodynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Nan; Battaglia, Francine; Pannala, Sreekanth

2008-01-01

Simulations of fluidized beds are performed to study and determine the effect on the use of coordinate systems and geometrical configurations to model fluidized bed reactors. Computational fluid dynamics is employed for an Eulerian-Eulerian model, which represents each phase as an interspersed continuum. The transport equation for granular temperature is solved and a hyperbolic tangent function is used to provide a smooth transition between the plastic and viscous regimes for the solid phase. The aim of the present work is to show the range of validity for employing simulations based on a 2D Cartesian coordinate system to approximate both cylindricalmore » and rectangular fluidized beds. Three different fluidization regimes, bubbling, slugging and turbulent regimes, are investigated and the results of 2D and 3D simulations are presented for both cylindrical and rectangular domains. The results demonstrate that a 2D Cartesian system can be used to successfully simulate and predict a bubbling regime. However, caution must be exercised when using 2D Cartesian coordinates for other fluidized regimes. A budget analysis that explains all the differences in detail is presented in Part II [N. Xie, F. Battaglia, S. Pannala, Effects of Using Two-Versus Three-Dimensional Computational Modeling of Fluidized Beds: Part II, budget analysis, 182 (1) (2007) 14] to complement the hydrodynamic theory of this paper.« less

An exploratory study of live vs. web-based delivery of a phlebotomy program.

PubMed

Fydryszewski, Nadine A; Scanlan, Craig; Guiles, H Jesse; Tucker, Ann

2010-01-01

Changes in student population and increased Web-based education offerings provided the impetus to assess pedagogy, cognitive outcomes and perceptions of course quality. This study explored cognitive outcomes and students' perception of course quality related to the Seven Principles for Good Practice in Undergraduate Education between live classroom delivery, compared to a Web-based delivery of a phlebotomy program. Quasi-experimental; students self-selected to enroll in live or Web-based program. For cognitive outcomes, no significant difference was found between the groups. Student perception of course quality differed only for Principle One (student-instructor contact). Students in the live classroom rated Principle One higher for the Part I course compared to the Web-based group. For the Part II course, there was no significant difference in perception of course quality related to any of the Seven Principles. The more constructivist pedagogy in the Part II course did not improve cognitive outcomes however, it may have contributed to knowledge retention. The live group rated Principle One in the Part II course evaluation relatively the same as they did for the Part I course evaluation. However, the Web-based group rated Principle One considerable higher for the Part II course than for Part I course. Future studies with a larger sample could explore improved course quality assessment instruments.

Change in equilibrium position of misfit dislocations at the GaN/sapphire interface by Si-ion implantation into sapphire. II. Electron energy loss spectroscopic study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Sung Bo, E-mail: bolee@snu.ac.kr; Han, Heung Nam, E-mail: hnhan@snu.ac.kr; Kim, Young-Min

In Part I, we have shown that the addition of Si into sapphire by ion implantationmakes the sapphire substrate elastically softer than for the undoped sapphire. The more compliant layer of the Si-implanted sapphire substrate can absorb the misfit stress at the GaN/sapphire interface, which produces a lower threading-dislocation density in the GaN overlayer. Here in Part II, based on experimental results by electron energy loss spectroscopy and a first-principle molecular orbital calculation in the literature, we suggest that the softening effect of Si results from a reduction of ionic bonding strength in sapphire (α-Al{sub 2}O{sub 3}) with the substitutionmore » of Si for Al.« less

Third-space fluid shift in elderly patients undergoing gastrointestinal surgery: Part II: nursing assessment.

PubMed

Wotton, Karen; Redden, Maurine

2002-08-01

Third-space fluid shift is the mobilisation of body fluid to a non-contributory space rendering it unavailable to the circulatory system. It is a recurrent clinical phenomenon requiring swift identification to minimise deleterious effects. Nurses experience difficulties however in its early identification, diagnosis and subsequent treatment because of the lack of consensual and consistent information regarding third-spacing. This article, part II, building on the previous article, explores the clinical validly and reliability of signs and symptoms of both phases of third-space fluid shift. In addition it reinforces the use multiple patient assessment cues if nurses are to differentiate between, and accurately respond to, the various causes of both hypovolaemia and hypervolaemia. It assists nurses to increase their knowledge and uderstanding of third-space fluid shift in patients undergoing gastrointestinal surgery.

Licensing in an international triopoly

NASA Astrophysics Data System (ADS)

Ferreira, Fernanda A.; Ferreira, Flávio

2011-12-01

We study the effects of entry of two foreign firms on domestic welfare in the presence of licensing, when the incumbent is technologically superior to the entrants. We consider two different situations: (i) the cost-reducing innovation is licensed to both entrants; (ii) the cost-reducing innovation is licensed to just one of the entrants. We analyse three kind of license: (lump-sum) fixed-fee; (per-unit) royalty; and two-part tariff, that is a combination of a fixed-fee and a royalty. We prove that a two part tariff is never an optimal licensing scheme for the incumbent. Moreover, (i) when the technology is licensed to the two entrants, the optimal contract consists of a licensing with only output royalty; and (ii) when the technology is licensed to just one of the entrants, the optimal contract consists of a licensing with only a fixed-fee.

Polarized Light Scanning Cryomacroscopy, Part II: Thermal Modeling and Analysis of Experimental Observations

PubMed Central

Feig, Justin S.G.; Solanki, Prem K.; Eisenberg, David P.; Rabin, Yoed

2016-01-01

This study aims at developing thermal analysis tools and explaining experimental observations made by means of polarized-light cryomacroscopy (Part I). Thermal modeling is based on finite elements analysis (FEA), where two model parameters are extracted from thermal measurements: (i) the overall heat transfer coefficient between the cuvette and the cooling chamber, and (ii) the effective thermal conductivity within the cryoprotective agent (CPA) at the upper part of the cryogenic temperature range. The effective thermal conductivity takes into account enhanced heat transfer due to convection currents within the CPA, creating the so-called Bénard cells. Comparison of experimental results with simulation data indicates that the uncertainty in simulations due to the propagation of uncertainty in measured physical properties exceeds the uncertainty in experimental measurements, which validates the modeling approach. It is shown in this study that while a cavity may form in the upper-center portion of the vitrified CPA, it has very little effect on estimating the temperature distribution within the domain. This cavity is driven by thermal contraction of the CPA, with the upper-center of the domain transitioning to glass last. Finally, it is demonstrated in this study that additional stresses may develop within the glass transition temperature range due to nonlinear behavior of the thermal expansion coefficient. This effect is reported here for the first time in the context of cryobiology, using the capabilities of polarized-light cryomacroscopy. PMID:27343139

Polarized light scanning cryomacroscopy, part II: Thermal modeling and analysis of experimental observations.

PubMed

Feig, Justin S G; Solanki, Prem K; Eisenberg, David P; Rabin, Yoed

2016-10-01

This study aims at developing thermal analysis tools and explaining experimental observations made by means of polarized-light cryomacroscopy (Part I). Thermal modeling is based on finite elements analysis (FEA), where two model parameters are extracted from thermal measurements: (i) the overall heat transfer coefficient between the cuvette and the cooling chamber, and (ii) the effective thermal conductivity within the cryoprotective agent (CPA) at the upper part of the cryogenic temperature range. The effective thermal conductivity takes into account enhanced heat transfer due to convection currents within the CPA, creating the so-called Bénard cells. Comparison of experimental results with simulation data indicates that the uncertainty in simulations due to the propagation of uncertainty in measured physical properties exceeds the uncertainty in experimental measurements, which validates the modeling approach. It is shown in this study that while a cavity may form in the upper-center portion of the vitrified CPA, it has very little effect on estimating the temperature distribution within the domain. This cavity is driven by thermal contraction of the CPA, with the upper-center of the domain transitioning to glass last. Finally, it is demonstrated in this study that additional stresses may develop within the glass transition temperature range due to nonlinear behavior of the thermal expansion coefficient. This effect is reported here for the first time in the context of cryobiology, using the capabilities of polarized-light cryomacroscopy. Copyright © 2016. Published by Elsevier Inc.

30 CFR 914.30 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2014 CFR

2014-07-01

....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

30 CFR 914.30 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2011 CFR

2011-07-01

....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

30 CFR 914.30 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2012 CFR

2012-07-01

....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

30 CFR 914.30 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2013 CFR

2013-07-01

....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

30 CFR 914.30 - State-Federal Cooperative Agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole - Part II: zebrafish

EPA Science Inventory

Disruption of the thyroid hormone (TH) system is increasingly being recognized as an important mode of action that can lead to ecologically relevant adverse outcomes, especially during embryonic development. The present study was designed to further characterize the effects of di...

42 CFR 423.120 - Access to covered Part D drugs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... pharmacists. (ii) Includes at least one practicing physician and at least one practicing pharmacist who are... manufacturers. (iii) Includes at least one practicing physician and one practicing pharmacist who are experts... pharmacists prior to the date such change becomes effective, and must either— (A) Provide direct written...

42 CFR 423.120 - Access to covered Part D drugs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... pharmacists. (ii) Includes at least one practicing physician and at least one practicing pharmacist who are... manufacturers. (iii) Includes at least one practicing physician and one practicing pharmacist who are experts... pharmacists prior to the date such change becomes effective, and must either— (A) Provide direct written...

Issue Management by School Superintendents: Final Report. Part II.

ERIC Educational Resources Information Center

Huff, Anne S.; Pondy, Louis R.

Four papers generated by a broader study of issues management in three suburban Chicago school districts are collected here. "Achieving Routine" focuses on the effective routinization of organizational change, in this case a curriculum decision, through the use of administrative mechanisms and the conceptual linkage of the new to…

Skewed steel bridges, part ii : cross-frame and connection design to ensure brace effectiveness : technical summary.

DOT National Transportation Integrated Search

2017-08-01

Skewed bridges in Kansas are often designed such that the cross-frames are carried parallel to the skew angle up to 40, while many other states place cross-frames perpendicular to the girder for skew angles greater than 20. Skewed-parallel cross-...

Skewed steel bridges, part ii : cross-frame and connection design to ensure brace effectiveness : final report.

DOT National Transportation Integrated Search

2017-08-01

Skewed bridges in Kansas are often designed such that the cross-frames are carried parallel to the skew angle up to 40, while many other states place cross-frames perpendicular to the girder for skew angles greater than 20. Skewed-parallel cross-...

LIMITATIONS ON THE USES OF MULTIMEDIA EXPOSURE MEASUREMENTS FOR MULTIPATHWAY EXPOSURE ASSESSMENT - PART II: EFFECTS OF MISSING DATA AND IMPRECISION

EPA Science Inventory

Multimedia data from two probability-based exposure studies were investigated in terms of how missing data and measurement-error imprecision affected estimation of population parameters and associations. Missing data resulted mainly from individuals' refusing to participate in c...

ENVIRONMENTAL EFFECTS OF WESTERN COAL COMBUSTION. PART II. THE AQUATIC MACROINVERTEBRATES OF ROSEBUD CREEK, MONTANA

EPA Science Inventory

The aquatic macroinvertebrates of Rosebud Creek, Montana, were sampled between February 1976 and March 1977 to provide data on their abundance, distribution, and diversity. The sampling program was initiated during the first year of operation of the coal-fired power plants locate...

Compaction of asphaltic concrete pavement with high intensity pneumatic roller : part II : densification due to traffic.

DOT National Transportation Integrated Search

1965-10-01

In the early of 1961 a research project was undertaken by the Louisiana Department of Highways in cooperation with the Bureau of Public Roads to study the effect of high intensity pneumatic rollers on the density of asphaltic concrete pavement using ...

The Disembodied Librarian in the Digital Age, Part II.

ERIC Educational Resources Information Center

Martell, Charles

2000-01-01

Discusses how four historical discontinuities (time and space, mind and body, real and virtual, and humans and technology) relate to new ways of being and thinking about the future of librarians and libraries. Topics include computers and books; entertainment industry growth; information uses; global economy effects; and future library…

The Development of Concepts of Handicap in Adolescence: A Cross Cultural Study, Part II.

ERIC Educational Resources Information Center

Obani, Tim; Doherty, Jim

1986-01-01

Presents the results of a study of English and Nigerian adolescents' conceptions of the causes, effects, rehabilitation, and interaction of handicaps. Cognitive maturity (related to age) proved to be the greatest factor influencing accuracy of perception. Samples of questions and anecdotes are included. (JDH)

12 CFR Appendix A to Part 1720 - Policy Guidance; Minimum Safety and Soundness Requirements

Code of Federal Regulations, 2014 CFR

2014-01-01

... maintains an effective risk management framework, including review of such framework to monitor its... credit quality. II. Balance sheet growth and management. III. Market risk. IV. Information technology. V..., measurement, monitoring, and management of market risk. The Enterprise should: i. Establish and implement...

12 CFR Appendix A to Part 1720 - Policy Guidance; Minimum Safety and Soundness Requirements

Code of Federal Regulations, 2012 CFR

2012-01-01

... maintains an effective risk management framework, including review of such framework to monitor its... credit quality. II. Balance sheet growth and management. III. Market risk. IV. Information technology. V..., measurement, monitoring, and management of market risk. The Enterprise should: i. Establish and implement...

12 CFR Appendix A to Part 1720 - Policy Guidance; Minimum Safety and Soundness Requirements

Code of Federal Regulations, 2013 CFR

2013-01-01

... maintains an effective risk management framework, including review of such framework to monitor its... credit quality. II. Balance sheet growth and management. III. Market risk. IV. Information technology. V..., measurement, monitoring, and management of market risk. The Enterprise should: i. Establish and implement...

Reexamination of color vision standards, part II. a computational method to assess the effect of color deficiencies in using ATC displays : final report.

DOT National Transportation Integrated Search

2006-03-01

The previous study showed that many colors were used in air traffic control displays. We also found that colors were used mainly for three purposes: capturing controllers immediate attention, identifying targets, and segmenting information. This r...

Phosphorylation of rat kidney Na-K pump at Ser938 is required for rapid angiotensin II-dependent stimulation of activity and trafficking in proximal tubule cells

PubMed Central

Massey, Katherine J.; Li, Quanwen; Rossi, Noreen F.; Keezer, Susan M.; Mattingly, Raymond R.

2015-01-01

How angiotensin (ANG) II acutely stimulates the Na-K pump in proximal tubules is only partially understood, limiting insight into how ANG II increases blood pressure. First, we tested whether ANG II increases the number of pumps in plasma membranes of native rat proximal tubules under conditions of rapid activation. We found that exposure to 100 pM ANG II for 2 min, which was previously shown to increase affinity of the Na-K pump for Na and stimulate activity threefold, increased the amount of the Na-K pump in plasma membranes of native tubules by 33%. Second, we tested whether previously observed increases in phosphorylation of the Na-K pump at Ser938 were part of the stimulatory mechanism. These experiments were carried out in opossum kidney cells, cultured proximal tubules stably coexpressing the ANG type 1 (AT1) receptor, and either wild-type or a S938A mutant of rat kidney Na-K pump under conditions found by others to stimulate activity. We found that 10 min of incubation in 10 pM ANG II stimulated activity of wild-type pumps from 2.3 to 3.5 nmol K·mg protein−1·min−1 and increased the amount of the pump in the plasma membrane by 80% but had no effect on cells expressing the S938A mutant. We conclude that acute stimulation of Na-K pump activity in native rat proximal tubules includes increased trafficking to the plasma membrane and that phosphorylation at Ser938 is part of the mechanism by which ANG II directly stimulates activity and trafficking of the rat kidney Na-K pump in opossum kidney cells. PMID:26582472

The effect of monthly 50,000 IU or 100,000 IU vitamin D supplements on vitamin D status in premenopausal Middle Eastern women living in Auckland.

PubMed

Mazahery, H; Stonehouse, W; von Hurst, P R

2015-03-01

Middle Eastern female immigrants are at an increased risk of vitamin D deficiency and their response to prescribed vitamin D dosages may not be adequate and affected by other factors. The objectives were to determine vitamin D deficiency and its determinants in Middle Eastern women living in Auckland, New Zealand (Part-I), and to determine serum 25-hydroxyvitamin D (serum-25(OH)D) response to two prescribed vitamin D dosages (Part-II) in this population. Women aged ⩾20 (n=43) participated in a cross-sectional pilot study during winter (Part-I). In Part-II, women aged 20-50 years (n=62) participated in a randomised, double-blind placebo-controlled trial consuming monthly either 50,000, 100,000 IU vitamin D3 or placebo for 6 months (winter to summer). All women in Part-I and 60% women in Part-II had serum-25(OH)D<50 nmol/l. Serum-25(OH)D was higher in prescribed vitamin D users than nonusers (P=0.001) and in Iranians than Arab women (P=0.001; Part-I). Mean (s.d.) serum-25(OH)D increased in all groups (time effect, P<0.001) and differed between groups (time × dosage interaction, P<0.001; 50,000 IU: from 44.0±16.0 to 70.0±15.0 nmol/l; 100,000 IU: 48.0±11.0 to 82.0±17.0 nmol/l; placebo: 45.0±18.0 to 54.0±18.0 nmol/l). Only 32% and 67% achieved serum-25(OH)D⩾75 nmol/l with 50,000 and 100,000 IU/month, respectively. Predictors of 6-month change in serum-25(OH)D were dose (B-coefficient±s.e.; 14.1±2.4, P<0.001), baseline serum-25(OH)D (-0.6±0.1, P<0.001) and body fat percentage (-0.7±0.3, P=0.01). Vitamin D deficiency/insufficiency is highly prevalent in this population. Monthly 100,000 IU vitamin D for 6 months is more effective than 50,000 IU in achieving serum-25(OH)D ⩾75 nmol/l; however, a third of women still did not achieve these levels.

Matematicas Para El Primer Ciclo Secundario, Volumen II (Parte 2). Traduccion Preliminar de la Edicion en Ingles Revisada. (Mathematics for Junior High School, Volume II, Part 2. Preliminary Translation of the Revised English Edition).

ERIC Educational Resources Information Center

Anderson, R. D.; And Others

This is part two of a two-part SMSG mathematics text for junior high school students. Key ideas emphasized are structure of arithmetic from an algebraic viewpoint, the real number system as a progressing development, and metric and non-metric relations in geometry. Chapter topics include real numbers, similar triangles, variation, polyhedrons,…

10 CFR Appendix B to Subpart A of... - Environmental Effect of Renewing the Operating License of a Nuclear Power Plant

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Environmental Effect of Renewing the Operating License of a Nuclear Power Plant B Appendix B to Subpart A of Part 51 Energy NUCLEAR REGULATORY COMMISSION... near these plants could be of moderate significance in some situations. See § 51.53(c)(3)(ii)(A...

Effects of Enhanced Laboratory Instructional Technique on Senior Secondary Students' Attitude toward Chemistry in Oyo Township, Oyo State, Nigeria

ERIC Educational Resources Information Center

Adesoji, Francis Adewumi; Raimi, Sikiru Morakinyo

2004-01-01

The study examined the effect of supplementing laboratory instruction with problem solving strategy and or practical skills teaching on students' attitude toward chemistry. A total of 286 senior secondary class II students (145 males and 141 females) drawn from four local government areas in Oyo township in Oyo state, Nigeria, took part in the…

Post-fire mulching for runoff and erosion mitigation; Part II: Effectiveness in reducing runoff and sediment yields from small catchments

Treesearch

Peter R. Robichaud; Joseph W. Wagenbrenner; Sarah A. Lewis; Louise E. Ashmun; Robert E. Brown; Peter M. Wohlgemuth

2013-01-01

Agricultural straw, hydromulch, and wood shred or wood strand mulches increasingly are being used as post-fire hillslope treatments, but the differences in effectiveness among these mulch treatments are not fully understood. Following the 2002 Hayman fire in central Colorado and the 2003 Cedar fire in southern California, matched catchments were monitored for five to...

Proceedings of the ARPA/AFML Review of Progress in Quantitative Nondestructive Evaluation (NDE)

DTIC Science & Technology

1977-09-01

degradation mechanisms. TABLE II. Experimental Methods for Study of Kolsture Effects Part 1: Malattira Dairadatlon Motatura taka up Intarlaalaat ahaar...1) To determine the effects of moisture de- gradation on the mechanical properties of a gra- phlte-epoxy composite under study for use on B-l. 2...a larger degree of reversibility in moisture damage effects . These are early results; further study of these Interesting results are required

Actualizing system benefits--Part II.

PubMed

Zinn, T K; DiGiulio, L W

1988-05-01

Do benefits impact the psychology of the information system buying decision? Is system success tied to achieving "promoted" benefits? Part II of this series reveals responses from a survey of some 3,000 executives about the importance of qualitative and quantitative benefits in the "buying process."

Part 1: Vadose-zone column studies of toluene (enhanced bioremediation) in a shallow unconfined aquifer

USGS Publications Warehouse

Tindall, J.A.; Friedel, M.J.; Szmajter, R.J.; Cuffin, S.M.

2005-01-01

The objectives of the laboratory study described in this paper were (1) to determine the effectiveness of four nutrient solutions and a control in stimulating the microbial degradation of toluene in the unsaturated zone as an alternative to bioremediation methodologies such as air sparging, in situ vitrification, or others (Part I), and (2) to compare the effectiveness of the addition of the most effective nutrient solution from Part I (modified Hoagland type, nitrate-rich) and hydrogen peroxide (H2O2) on microbial degradation of toluene for repeated, simulated spills in the unsaturated zone (Part II). For Part 1, fifteen columns (30-cm diameter by 150-cm height), packed with air-dried, 0.25-mm, medium-fine sand, were prepared to simulate shallow unconfined aquifer conditions. Toluene (10 mL) was added to the surface of each column, and soil solution and soil gas samples were collected from the columns every third day for 21 days. On day 21, a second application of toluene (10 mL) was made, and the experiment was run for another 21 days. Solution 4 was the most effective for microbial degradation in Part I. For Part II, three columns were designated nutrient-rich 3-day toluene columns and received toluene injections every 3 days; three columns were designated as nutrient-rich 7-day columns and received toluene injections every 7 days; and two columns were used as controls to which no nutrient was added. As measured by CO2 respiration, the initial benefits for aerobic organisms from the O2 enhancement were sustained by the bacteria for only a short period of time (about 8 days). Degradation benefits from the nutrient solution were sustained throughout the experiment. The O2 and nutrient-enhanced columns degraded significantly more toluene than the control columns when simulating repeated spills onto the unsaturated zone, and demonstrated a potentially effective in situ bioremediation technology when used immediately or within days after a spill. The combined usage of H 2O2 and nitrate-rich nutrients served to effectively maximize natural aerobic and anaerobic metabolic processes that biodegrade hydrocarbons in petroleum-contaminated media. Applications of this technology in the field may offer economical advantages to other, more intrusive abatement technologies. ?? Springer 2005.

Verbal and Visual Memory Impairments in Bipolar I and II Disorder.

PubMed

Ha, Tae Hyon; Kim, Ji Sun; Chang, Jae Seung; Oh, Sung Hee; Her, Ju Young; Cho, Hyun Sang; Park, Tae Sung; Shin, Soon Young; Ha, Kyooseob

2012-12-01

To compare verbal and visual memory performances between patients with bipolar I disorder (BD I) and patients with bipolar II disorder (BD II) and to determine whether memory deficits were mediated by impaired organizational strategies. Performances on the Korean-California Verbal Learning Test (K-CVLT) and the Rey-Osterrieth Complex Figure Test (ROCF) in 37 patients with BD I, 46 patients with BD II and 42 healthy subjects were compared. Mediating effects of impaired organization strategies on poor delayed recall was tested by comparing direct and mediated models using multiple regression analysis. Both patients groups recalled fewer words and figure components and showed lower Semantic Clustering compared to controls. Verbal memory impairment was partly mediated by difficulties in Semantic Clustering in both subtypes, whereas the mediating effect of Organization deficit on the visual memory impairment was present only in BD I. In all mediated models, group differences in delayed recall remained significant. Our findings suggest that memory impairment may be one of the fundamental cognitive deficits in bipolar disorders and that executive dysfunctions can exert an additional influence on memory impairments.

VenUS IV (Venous leg Ulcer Study IV) - compression hosiery compared with compression bandaging in the treatment of venous leg ulcers: a randomised controlled trial, mixed-treatment comparison and decision-analytic model.

PubMed

Ashby, Rebecca L; Gabe, Rhian; Ali, Shehzad; Saramago, Pedro; Chuang, Ling-Hsiang; Adderley, Una; Bland, J Martin; Cullum, Nicky A; Dumville, Jo C; Iglesias, Cynthia P; Kang'ombe, Arthur R; Soares, Marta O; Stubbs, Nikki C; Torgerson, David J

2014-09-01

Compression is an effective and recommended treatment for venous leg ulcers. Although the four-layer bandage (4LB) is regarded as the gold standard compression system, it is recognised that the amount of compression delivered might be compromised by poor application technique. Also the bulky nature of the bandages might reduce ankle or leg mobility and make the wearing of shoes difficult. Two-layer compression hosiery systems are now available for the treatment of venous leg ulcers. Two-layer hosiery (HH) may be advantageous, as it has reduced bulk, which might enhance ankle or leg mobility and patient adherence. Some patients can also remove and reapply two-layer hosiery, which may encourage self-management and could reduce costs. However, little robust evidence exists about the effectiveness of two-layer hosiery for ulcer healing and no previous trials have compared two-layer hosiery delivering 'high' compression with the 4LB. Part I To compare the clinical effectiveness and cost-effectiveness of HH and 4LB in terms of time to complete healing of venous leg ulcers. Part II To synthesise the relative effectiveness evidence (for ulcer healing) of high-compression treatments for venous leg ulcers using a mixed-treatment comparison (MTC). Part III To construct a decision-analytic model to assess the cost-effectiveness of high-compression treatments for venous leg ulcers. Part I A multicentred, pragmatic, two-arm, parallel, open randomised controlled trial (RCT) with an economic evaluation. Part II MTC using all relevant RCT data - including Venous leg Ulcer Study IV (VenUS IV). Part III A decision-analytic Markov model. Part I Community nurse teams or services, general practitioner practices, leg ulcer clinics, tissue viability clinics or services and wound clinics within England and Northern Ireland. Part I Patients aged ≥ 18 years with a venous leg ulcer, who were willing and able to tolerate high compression. Part I Participants in the intervention group received HH. The control group received the 4LB, which was applied according to standard practice. Both treatments are designed to deliver 40 mmHg of compression at the ankle. Part II and III All relevant high-compression treatments including HH, the 4LB and the two-layer bandage (2LB). Part I The primary outcome measure was time to healing of the reference ulcer (blinded assessment). Part II Time to ulcer healing. Part III Quality-adjusted life-years (QALYs) and costs. Part I A total of 457 participants were recruited. There was no evidence of a difference in time to healing of the reference ulcer between groups in an adjusted analysis [hazard ratio (HR) 0.99, 95% confidence interval (CI) 0.79 to 1.25; p = 0.96]. Time to ulcer recurrence was significantly shorter in the 4LB group (HR = 0.56, 95% CI 0.33 to 0.94; p = 0.026). In terms of cost-effectiveness, using QALYs as the measure of benefit, HH had a > 95% probability of being the most cost-effective treatment based on the within-trial analysis. Part II The MTC suggests that the 2LB has the highest probability of ulcer healing compared with other high-compression treatments. However, this evidence is categorised as low to very low quality. Part III Results suggested that the 2LB had the highest probability of being the most cost-effective high-compression treatment for venous leg ulcers. Trial data from VenUS IV found no evidence of a difference in venous ulcer healing between HH and the 4LB. HH may reduce ulcer recurrence rates compared with the 4LB and be a cost-effective treatment. When all available high-compression treatments were considered, the 2LB had the highest probability of being clinically effective and cost-effective. However, the underpinning evidence was sparse and more research is needed. Further research should thus focus on establishing, in a high-quality trial, the effectiveness of this compression system in particular. Current Controlled Trials ISRCTN49373072. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 18, No. 57. See the NIHR Journals Library website for further project information.

An Interactive Activation Model of the Effect of Context in Perception. Part 2

DTIC Science & Technology

1980-07-15

nonword strings are often seen with letters transposed if the transposition will produce legal strings (Estes, 1975a; c.f. experiment by Stevens reported...Activation Model Rumelhart & McClelland Part II 90 References Anderson, J. A. Neural models with cognitive implications. In D. LaBerge & S. J. Samuels...Washington, DC 20372 Coe391 Dr. Gory PoockNavy Personnel R&D Center Operations Research Department LT Steven D. Harris. MSC, USN San Diego, CA 92152 Code

Modeling Impact-induced Failure of Polysilicon MEMS: A Multi-scale Approach.

PubMed

Mariani, Stefano; Ghisi, Aldo; Corigliano, Alberto; Zerbini, Sarah

2009-01-01

Failure of packaged polysilicon micro-electro-mechanical systems (MEMS) subjected to impacts involves phenomena occurring at several length-scales. In this paper we present a multi-scale finite element approach to properly allow for: (i) the propagation of stress waves inside the package; (ii) the dynamics of the whole MEMS; (iii) the spreading of micro-cracking in the failing part(s) of the sensor. Through Monte Carlo simulations, some effects of polysilicon micro-structure on the failure mode are elucidated.

Revised Olweus Bully/Victim Questionnaire: evaluation in visually impaired.

PubMed

Gothwal, Vijaya K; Sumalini, Rebecca; Irfan, Shaik Mohammad; Giridhar, Avula; Bharani, Seelam

2013-08-01

To explore the psychometric properties of the revised Olweus Bully/Victim Questionnaire (OBVQ) in children with visual impairment (VI) using Rasch analysis. One hundred fifty Indian children with VI between 8 and 16 years (mean age, 11.6 years; 69% male; mean acuity in the better eye of 0.80 logMAR [Snellen, 20/126]) were administered the revised OBVQ. The 40-item revised OBVQ was developed to assess victimization (i.e., being bullied) and bullying (bullying others) in normally sighted schoolchildren. Only 16 items are used for Rasch analysis and are divided into two parts: I (victimization, eight items) and II (bullying others, eight items). Separate Rasch analysis was conducted for both parts, and the psychometric properties investigated included behavior of rating scale, extent to which the items measured a single construct (unidimensionality by fit statistics and principal component analysis [PCA] of residuals); ability to discriminate among participants' victimization and bullying behaviors (measurement precision as assessed by person separation reliability [PSR] minimum recommended value, 0.80); and targeting of items to participants' victimization and bullying. Response categories were misused for both parts I and II, which required repair before further analysis. Measurement precision was inadequate for both parts (PSR, 0.64 for part I and 0.19 for part II), indicating poor discriminatory ability. All items fit the Rasch model well in part I, indicating unidimensionality that was further confirmed using PCA of residuals. However, an item misfit in part II that required deletion following which the remaining items fit and PCA of residuals also supported unidimensionality. Targeting was -0.58 logits for part I, indicating that the items were matched well with the participants' victimization. By comparison, targeting was suboptimal for part II (-1.97 logits). In its current state, the revised OBVQ is not a valid psychometric instrument to assess victimization and bullying among children with VI.

AUTOMOTIVE DIESEL MAINTENANCE L. UNIT XII, PART I--MAINTAINING THE FUEL SYSTEM (PART II), CUMMINS DIESEL ENGINE, PART II--UNIT INSTALLATION (ENGINE).

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF THE DIESEL ENGINE FUEL SYSTEM AND THE PROCEDURES FOR DIESEL ENGINE INSTALLATION. TOPICS ARE FUEL FLOW CHARACTERISTICS, PTG FUEL PUMP, PREPARATION FOR INSTALLATION, AND INSTALLING ENGINE. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL BRANCH…

Literacy and Deaf Students in Taiwan: Issues, Practices and Directions for Future Research--Part II

ERIC Educational Resources Information Center

Liu, Hsiu Tan; Andrews, Jean F.; Liu, Chun Jung

2014-01-01

In Part I, we underscore the issues surrounding young deaf and hard of hearing (DHH) learners of literacy in Taiwan who use sign to support their learning of Chinese literacy. We also described the linguistic features of Chinese writing and the visual codes used by DHH children. In Part II, we describe the reading and writing practices used with…

48 CFR 3415.406-3 - Part II-Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Part II-Contract clauses. 3415.406-3 Section 3415.406-3 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and...

Joint Stability Characteristics of the Ankle Complex in Female Athletes With Histories of Lateral Ankle Sprain, Part II: Clinical Experience Using Arthrometric Measurement

PubMed Central

Kovaleski, John E.; Heitman, Robert J.; Gurchiek, Larry R.; Hollis, J. M.; Liu, Wei; IV, Albert W. Pearsall

2014-01-01

Context: This is part II of a 2-part series discussing stability characteristics of the ankle complex. In part I, we used a cadaver model to examine the effects of sectioning the lateral ankle ligaments on anterior and inversion motion and stiffness of the ankle complex. In part II, we wanted to build on and apply these findings to the clinical assessment of ankle-complex motion and stiffness in a group of athletes with a history of unilateral ankle sprain. Objective: To examine ankle-complex motion and stiffness in a group of athletes with reported history of lateral ankle sprain. Design: Cross-sectional study. Setting: University research laboratory. Patients or Other Participants: Twenty-five female college athletes (age = 19.4 ± 1.4 years, height = 170.2 ± 7.4 cm, mass = 67.3 ± 10.0 kg) with histories of unilateral ankle sprain. Intervention(s): All ankles underwent loading with an ankle arthrometer. Ankles were tested bilaterally. Main Outcome Measure(s): The dependent variables were anterior displacement, anterior end-range stiffness, inversion rotation, and inversion end-range stiffness. Results: Anterior displacement of the ankle complex did not differ between the uninjured and sprained ankles (P = .37), whereas ankle-complex rotation was greater for the sprained ankles (P = .03). The sprained ankles had less anterior and inversion end-range stiffness than the uninjured ankles (P < .01). Conclusions: Changes in ankle-complex laxity and end-range stiffness were detected in ankles with histories of sprain. These results indicate the presence of altered mechanical characteristics in the soft tissues of the sprained ankles. PMID:24568223

Extending the collisional fluid equations into the long mean-free-path regime in toroidal plasmas. IV. Banana regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaing, K. C.

In Part I [Phys. Fluids B 2, 1190 (1990)] and Part II [Phys. Plasmas 12, 082508 (2005)], it was emphasized that the equilibrium plasma viscous forces when applied for the magnetohydrodynamic (MHD) modes are only rigorously valid at the mode rational surface where m-nq=0. Here, m is the poloidal mode number, n is the toroidal mode number, and q is the safety factor. This important fact has been demonstrated explicitly by calculating the viscous forces in the plateau regime in Parts I and II. Here, the effective viscous forces in the banana regime are calculated for MHD modes by solvingmore » the linear drift kinetic equation that is driven by the plasma flows first derived in Part I. At the mode rational surface, the equilibrium plasma viscous forces are reproduced. However, it is found that away from the mode rational surface, the viscous forces for MHD modes decrease, a behavior similar to that observed in the viscous forces for the plateau regime. The proper form of the momentum equation that is appropriate for the modeling of the MHD modes is also discussed.« less

Active Control of Low-Speed Fan Tonal Noise Using Actuators Mounted in Stator Vanes: Part III Results

NASA Technical Reports Server (NTRS)

Sutliff, Daniel L.; Remington, Paul J.; Walker, Bruce E.

2003-01-01

A test program to demonstrate simplification of Active Noise Control (ANC) systems relative to standard techniques was performed on the NASA Glenn Active Noise Control Fan from May through September 2001. The target mode was the m = 2 circumferential mode generated by the rotor-stator interaction at 2BPF. Seven radials (combined inlet and exhaust) were present at this condition. Several different error-sensing strategies were implemented. Integration of the error-sensors with passive treatment was investigated. These were: (i) an in-duct linear axial array, (ii) an induct steering array, (iii) a pylon-mounted array, and (iv) a near-field boom array. The effect of incorporating passive treatment was investigated as well as reducing the actuator count. These simplified systems were compared to a fully ANC specified system. Modal data acquired using the Rotating Rake are presented for a range of corrected fan rpm. Simplified control has been demonstrated to be possible but requires a well-known and dominant mode signature. The documented results here in are part III of a three-part series of reports with the same base title. Part I and II document the control system and error-sensing design and implementation.

Matematicas Para El Primer Ciclo Secundario, Volumen II (Parte 1). Traduccion Preliminar de la Edicion en Ingles Revisada. (Mathematics for Junior High School, Volume II, Part 1. Preliminary Translation of the Revised English Edition).

ERIC Educational Resources Information Center

Anderson, R. D.; And Others

This is part one of a two-part SMSG mathematics text for junior high school students. Key ideas emphasized are structure of arithmetic from an algebraic viewpoint, the real number system as a progressing development, and metric and non-metric relations in geometry. Chapter topics include number line and coordinates, equations, scientific notation,…

Part I: Steady States in Two-Species Particle Aggregation. Part II: Sparse Representations for Multiscale PDE

DTIC Science & Technology

2015-03-01

University of California Los Angeles Part I: Steady States in Two-Species Particle Aggregation Part II: Sparse Representations for Multiscale PDE A ...Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a ...penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE MAR 2015

[Individual Types Reactivity of EEG Oscillations in Effective Heart Rhythm Biofeedback Parameters in Adolescents and Young People in the North].

PubMed

Krivonogova, E V; Poskotinova, L V; Demin, D B

2015-01-01

A single session of heart rate variability (HRV) biofeedback in apparently healthy young people and adolescents aged 14-17 years in order to increase vagal effects on heart rhythm and also electroencephalograms were carried out. Different variants of EEG spectral power during the successful HRV biofeedback session were identified. In the case of I variant of EEG activity the increase of power spectrum of alpha-, betal-, theta-components takes place in all parts of the brain. In the case of II variant of EEG activity the reduction of power spectrum of alpha-, betal-, theta-activity in all parts of the brain was observed. I and II variants of EEG activity cause more intensive regime of cortical-subcortical interactions. During the III variant of EEG activity the successful biofeedback is accompanied by increase of alpha activity in the central, front and anteriofrontal brain parts and so indicates the formation of thalamocortical relations of neural network in order to optimize the vegetal regulation of heart function. There was an increase in alpha- and beta1-activity in the parietal, central, frontal and temporal brain parts during the IV variant of EEG activity and so that it provides the relief of neural networks communication for information processing. As a result of V variance of EEG activity there was the increase of power spectrum of theta activity in the central and frontal parts of both cerebral hemispheres, so it was associated with the cortical-hippocampal interactions to achieve a successful biofeedback.

Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model

PubMed Central

Seremwe, Mutsa; Schnellmann, Rick G.

2015-01-01

Aldosterone is a steroid hormone important in the regulation of blood pressure. Aberrant production of aldosterone results in the development and progression of diseases including hypertension and congestive heart failure; therefore, a complete understanding of aldosterone production is important for developing more effective treatments. Angiotensin II (AngII) regulates steroidogenesis, in part through its ability to increase intracellular calcium levels. Calcium can activate calpains, proteases classified as typical or atypical based on the presence or absence of penta-EF-hands, which are involved in various cellular responses. We hypothesized that calpain, in particular calpain-10, is activated by AngII in adrenal glomerulosa cells and underlies aldosterone production. Our studies showed that pan-calpain inhibitors reduced AngII-induced aldosterone production in 2 adrenal glomerulosa cell models, primary bovine zona glomerulosa and human adrenocortical carcinoma (HAC15) cells, as well as CYP11B2 expression in the HAC15 cells. Although AngII induced calpain activation in these cells, typical calpain inhibitors had no effect on AngII-elicited aldosterone production, suggesting a lack of involvement of classical calpains in this process. However, an inhibitor of the atypical calpain, calpain-10, decreased AngII-induced aldosterone production. Consistent with this result, small interfering RNA (siRNA)-mediated knockdown of calpain-10 inhibited aldosterone production and CYP11B2 expression, whereas adenovirus-mediated overexpression of calpain-10 resulted in increased AngII-induced aldosterone production. Our results indicate that AngII-induced activation of calpain-10 in glomerulosa cells underlies aldosterone production and identify calpain-10 or its downstream pathways as potential targets for the development of drug therapies for the treatment of hypertension. PMID:25836666

Nonlinear effects in a plain journal bearing. I - Analytical study. II - Results

NASA Technical Reports Server (NTRS)

Choy, F. K.; Braun, M. J.; Hu, Y.

1991-01-01

In the first part of this work, a numerical model is presented which couples the variable-property Reynolds equation with a rotor-dynamics model for the calculation of a plain journal bearing's nonlinear characteristics when working with a cryogenic fluid, LOX. The effects of load on the linear/nonlinear plain journal bearing characteristics are analyzed and presented in a parametric form. The second part of this work presents numerical results obtained for specific parametric-study input variables (lubricant inlet temperature, external load, angular rotational speed, and axial misalignment). Attention is given to the interrelations between pressure profiles and bearing linear and nonlinear characteristics.

Electromagnetic pulse (EMP), Part II: Field-expedient ways to minimize its effects on field medical treatment facilities.

PubMed

Vandre, R H; Klebers, J; Tesche, F M; Blanchard, J P

1993-05-01

Part I of this paper showed that a field commander can expect approximately 65% of his unprotected electronic medical equipment to be damaged by the electromagnetic pulse (EMP) from a single nuclear detonation as far as 2200 km away. Using computer modeling, field-expedient ways to minimize the effects of EMP were studied. The results were: (1) keep wiring near the ground, (2) keep wiring short, (3) unplug unused equipment, (4) run power cabling and tents in a magnetic north-south direction (avoid running power cabling in the east-west direction), and (5) place sensitive equipment in International Organization for Standardization shelters.

Multi-year application of WRF-CAM5 over East Asia-Part II: Interannual variability, trend analysis, and aerosol indirect effects

NASA Astrophysics Data System (ADS)

Zhang, Yang; Wang, Kai; He, Jian

2017-09-01

Following a comprehensive evaluation of WRF-CAM5 in Part I, Part II describes analyses of interannual variability, multi-year variation trends, and the direct, indirect, and total effects of anthropogenic aerosols. The interannual variations of chemical column and surface concentrations, and ozone (O3)/particulate matter (PM) indicators are strongly correlated to anthropogenic emission changes. Despite model biases, the model captures well the observed interannual variations of temperature at 2-m, cloud fraction, shortwave cloud forcing, downwelling shortwave radiation, cloud droplet number concentration, column O3, and column formaldehyde (HCHO) for the whole domain. While the model reproduces the volatile organic compound (VOC)-limited regimes of O3 chemistry at sites in Hong Kong, Taiwan, Japan, South Korea, and from the Acid Deposition Monitoring Network in East Asia (EANET) and the degree of sulfate neutralization at the EANET sites, it has limited capability in capturing the interannual variations of the ratio of O3 and nitrogen dioxide (O3/NO2) and PM chemical regime indicators, due to uncertainties in the emissions of precursors for O3 and secondary PM, the model assumption for ammonium bisulfate (NH4HSO4) as well as lack of gas/particle partitioning of total ammonia and total nitrate. While the variation trends in multi-year periods in aerosol optical depth and column concentrations of carbon monoxide, sulfur dioxide, and NO2 are mainly caused by anthropogenic emissions, those of major meteorological and cloud variables partly reflect feedbacks of chemistry to meteorological variables. The impacts of anthropogenic aerosol indirect effects either dominate or play an important role in the aerosol total effects for most cloud and chemical predictions, whereas anthropogenic aerosol direct effects influence most meteorological and radiation variables. The direct, indirect, and total effects of anthropogenic aerosols exhibit a strong interannual variability in 2001, 2006, and 2011.

Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.

PubMed

Li, Jin-Lian; Fujiyama, Fumino; Kaneko, Takeshi; Mizuno, Noboru

2003-03-10

We examined immunohistochemically whether the vesicular glutamate transporters (VGluTs), VGluT1 and VGluT2, might be expressed in synaptic terminals of nociceptive primary afferent fibers within laminae I and II of the medullary and spinal dorsal horns of the rat. VGluT1 immunoreactivity (IR) was intense in the inner part of lamina II but weak in lamina I and the outer part of lamina II. VGluT2-IR was most intense in lamina I and the outer part of lamina II. Expression of VGluTs in synaptic terminals was confirmed by dual immunofluorescence histochemistry for VGluTs and synaptophysin. Expression of VGluTs in axon terminals of primary afferent fibers terminating in laminae I and II was also confirmed immunohistochemically after unilateral dorsal rhizotomy. The dual immunofluorescence histochemistry indicated expression of VGluTs in substance P (SP)-containing axon terminals in lamina I and the outer part of lamina II. Electron microscopy confirmed the coexpression of VGluTs and SP in axon terminals within laminae I and II; VGluTs was associated with round synaptic vesicles at the asymmetric synapses. It was further observed that isolectin IB4, a marker for unmyelinated axons, often bound with VGluT2-immunopositive structures but rarely with VGluT1-immunopositive structures in lamina II. Thus, the results indicated in laminae I and II of the medullary and spinal dorsal horns that both VGluT1 and VGluT2 were expressed in axon terminals of primary afferent fibers, including SP-containing nociceptive fibers and that VGluT in unmyelinated primary afferent fibers terminating in lamina II was primarily VGluT2. Copyright 2003 Wiley-Liss, Inc.

Evaluation of a single cell and candidate materials with high water content hydrogen in a generic solid oxide fuel cell stack test fixture, Part II: materials and interface characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chou, Y. S.; Stevenson, Jeffry W.; Choi, Jung-Pyung

2013-01-01

A generic solid oxide fuel cell (SOFC) test fixture was developed to evaluate candidate materials under realistic conditions. A commerical 50 mm x 50 mm NiO-YSZ anode supported thin YSZ electrolyte cell with lanthanum strontium manganite (LSM) cathode was tested to evaluate the stability of candidate materials. The cell was tested in two stages at 800oC: stage I of low (~3% H2O) humidity and stage II of high (~30% H2O) humidity hydrogen fuel at constant voltage or constant current mode. Part I of the work was published earlier with information of the generic test fixture design, materials, cell performance, andmore » optical post-mortem analysis. In part II, detailed microstructure and interfacial characterizations are reported regarding the SOFC candidate materials: (Mn,Co)-spinel conductive coating, alumina coating for sealing area, ferritic stainless steel interconnect, refractory sealing glass, and their interactions with each other. Overall, the (Mn,Co)-spinel coating was very effective in minimizing Cr migration. No Cr was identified in the cathode after 1720h at 800oC. Aluminization of metallic interconnect also proved to be chemically compatible with alkaline-earth silicate sealing glass. The details of interfacial reaction and microstructure development are discussed.« less

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit G: Resources for Managerial Assistance. Research and Development Series No. 194 B-7.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is establishing business. Unit G focuses on obtaining managerial…

Final Report for Dynamic Models for Causal Analysis of Panel Data. Models for Change in Quantitative Variables, Part II Scholastic Models. Part II, Chapter 4.

ERIC Educational Resources Information Center

Hannan, Michael T.

This document is part of a series of chapters described in SO 011 759. Stochastic models for the sociological analysis of change and the change process in quantitative variables are presented. The author lays groundwork for the statistical treatment of simple stochastic differential equations (SDEs) and discusses some of the continuities of…

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit A: Developing the Business Plan. Research and Development Series No. 194 B-1.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is establishing a business. Unit A focuses on developing a business…

U.S. Coast Guard 1994 Oil Pollution Research Grants Publications - Part II.

DTIC Science & Technology

1996-09-01

preparations. However, toxicity testing in various salinities may be of future interest in a number of cases. We have no direct data on the effect of different...of oil toxicity. Factors such as temperature (Korn et al. 1979), salinity (Linden et al. 1979), pH and route of exposure (Lee et al. 1976) may effect ...Evidence of altered metabolic pathways provides information concerning enzyme systems sensitive to oil-dispersant expostre. Any factors effecting these

EFFECTS OF BIOSOLIDS APPLICATION ON EROSION CONTROL AND ECOSYSTEM RECOVERY FOLLOWING THE BUFFALO CREEK FIRE - PART II

EPA Science Inventory

Nutrient (i.e. nitrogen) contamination of surface waters constitutes one of the most pervasive problems facing wastewater treatment works across the country. Nitrogen discharge to surface water occurs mostly in the form of ammonia which is identified as the most toxic nitrogen sp...

Use of Genomic Data in Risk Assessment Caes Study: II. Evaluation of the Dibutyl Phthalate Toxicogenomic Dataset

EPA Science Inventory

An evaluation of the toxicogenomic data set for dibutyl phthalate (DBP) and male reproductive developmental effects was performed as part of a larger case study to test an approach for incorporating genomic data in risk assessment. The DBP toxicogenomic data set is composed of ni...

42 CFR 417.802 - Allowable costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... procedures under which the members of the group accept effective incentives, such as risk-sharing, designed... physicians and other suppliers in the same or a similar locality. (ii)(A) If a physician group to whom the... group may not exceed the reasonable charges for those services, as defined in subpart E of part 405 of...

30 CFR 913.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

30 CFR 913.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

30 CFR 913.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

30 CFR 913.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

30 CFR 913.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

30 CFR 906.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Endangered Species Act, 16 U.S.C. 1531 et seq., and implementing regulations including 50 CFR part 402. 5..., in accordance with the Act and the Program. Article II: Effective Date 3. After being signed by the... except as otherwise stated in this Agreement, the Act, 30 CFR 745.13, or other applicable laws. Orders...

30 CFR 906.30 - State-Federal cooperative agreement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Endangered Species Act, 16 U.S.C. 1531 et seq., and implementing regulations including 50 CFR part 402. 5..., in accordance with the Act and the Program. Article II: Effective Date 3. After being signed by the... except as otherwise stated in this Agreement, the Act, 30 CFR 745.13, or other applicable laws. Orders...

Hypertension in Children and Adolescents. Part II: Pharmacologic Control--What Works and Why.

ERIC Educational Resources Information Center

Daniels, Stephen R.; Loggie, Jennifer M. H.

1992-01-01

In discussing pharmacologic control of hypertension in children and adolescents who participate in sports, the second of two articles emphasizes drugs with few side effects and that usually do not alter heart rate (e.g., long-lasting angiotensin-converting enzyme inhibitors or calcium channel blockers). Such drugs allow continued sports…

30 CFR 75.1103-5 - Automatic fire warning devices; actions and response.

Code of Federal Regulations, 2010 CFR

2010-07-01

... level reaches 10 parts per million above the established ambient level at any sensor location, automatic fire sensor and warning device systems shall provide an effective warning signal at the following... endangered and (ii) A map or schematic that shows the locations of sensors, and the intended air flow...

19 CFR 10.191 - General.

Code of Federal Regulations, 2011 CFR

2011-04-01

... articles for purposes of the CBI on January 1, 1994, as the CBI was in effect on that date. (ii) Footwear... analog, if such watches or watch parts contain any material which is the product of any country with... two or more beneficiary countries and to all materials incorporated in an article which have been...

19 CFR 10.191 - General.

Code of Federal Regulations, 2012 CFR

2012-04-01

... articles for purposes of the CBI on January 1, 1994, as the CBI was in effect on that date. (ii) Footwear... analog, if such watches or watch parts contain any material which is the product of any country with... two or more beneficiary countries and to all materials incorporated in an article which have been...

19 CFR 10.191 - General.

Code of Federal Regulations, 2013 CFR

2013-04-01

... articles for purposes of the CBI on January 1, 1994, as the CBI was in effect on that date. (ii) Footwear... analog, if such watches or watch parts contain any material which is the product of any country with... two or more beneficiary countries and to all materials incorporated in an article which have been...

19 CFR 10.191 - General.

Code of Federal Regulations, 2014 CFR

2014-04-01

... articles for purposes of the CBI on January 1, 1994, as the CBI was in effect on that date. (ii) Footwear... analog, if such watches or watch parts contain any material which is the product of any country with... two or more beneficiary countries and to all materials incorporated in an article which have been...

34 CFR 668.82 - Standard of conduct.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Upon learning of a conviction, plea, or administrative or judicial determination described in paragraph.... 12549 (3 CFR, 1986 Comp., p. 189) or the FAR, 48 CFR part 9, subpart 9.4; and (ii) Upon learning of the... period of 60 days, beginning on the effective date specified in the notice by the Secretary under 2 CFR...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2014 CFR

2014-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2012 CFR

2012-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2011 CFR

2011-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

21 CFR 1271.10 - Are my HCT/P's regulated solely under section 361 of the PHS Act and the regulations in this part...

Code of Federal Regulations, 2013 CFR

2013-04-01

... primary function; or (ii) The HCT/P has a systemic effect or is dependent upon the metabolic activity of living cells for its primary function, and: (a) Is for autologous use; (b) Is for allogeneic use in a...

Health effects of acute exposure to air polllution. Part II: Healthy subjects exposed to cencentrated ambient particles

EPA Science Inventory

The purpose of this study was to assess the impact of short-term exposure to concentrated ambient particles (CAPs*) on lung function and on inflammatory parameters in blood and airways of healthy human subjects. Particles were concentrated from the ambient air in Chapel Hill, Nor...

Stability and control of flexible satellites. II - Control

NASA Technical Reports Server (NTRS)

Huang, T. C.; Das, A.

1980-01-01

It is demonstrated that by monitoring the deformations of the flexible elements of a satellite, the effectiveness of the satellite control system can be increased considerably. A simple model of a flexible satellite was analyzed in the first part of this work. The same model is used here for digital computer simulations.

Metabolism: Part II. The Tricarboxylic Acid (TCA), Citric Acid, or Krebs Cycle.

ERIC Educational Resources Information Center

Bodner, George M.

1986-01-01

Differentiates the tricarboxylic acid (TCA) cycle (or Krebs cycle) from glycolysis, and describes the bridge between the two as being the conversion of pyruvate into acetyl coenzyme A. Discusses the eight steps in the TCA cycle, the results of isotopic labeling experiments, and the net effects of the TCA cycle. (TW)

Technology transfer package on seismic base isolation - Volume II

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-02-14

This Technology Transfer Package provides some detailed information for the U.S. Department of Energy (DOE) and its contractors about seismic base isolation. Intended users of this three-volume package are DOE Design and Safety Engineers as well as DOE Facility Managers who are responsible for reducing the effects of natural phenomena hazards (NPH), specifically earthquakes, on their facilities. The package was developed as part of DOE's efforts to study and implement techniques for protecting lives and property from the effects of natural phenomena and to support the International Decade for Natural Disaster Reduction. Volume II contains the proceedings for the Shortmore » Course on Seismic Base Isolation held in Berkeley, California, August 10-14, 1992.« less

The people side of MRP (materiel requirements planning).

PubMed

Lunn, T

1994-05-01

A montage of ideas and concepts have been successfully used to train and motivate people to use MRP II systems more effectively. This is important today because many companies are striving to achieve World Class Manufacturing status. Closed loop Materiel Requirements Planning (MRP) systems are an integral part of the process of continuous improvement. Successfully using a formal management planning system, such as MRP II, is a fundamental stepping stone on the path toward World Class Excellence. Included in this article are techniques that companies use to reduce lead time, simplify bills of materiel, and improve schedule adherence. These and other steps all depend on the people who use the system. The focus will be on how companies use the MRP tool more effectively.

Controlling Salmonella infection in weanling pigs through water delivery of direct-fed microbials or organic acids: Part II. Effects on intestinal histology and active nutrient transport

USDA-ARS?s Scientific Manuscript database

The objective of this study was to evaluate the effects of water-delivered direct-fed microbials (DFM) or organic acids on intestinal morphology and active nutrient absorption in weanling pigs following deliberate Salmonella infection. Pigs (n = 88) were weaned at 19 ± 2 d of age and assigned to one...

The Effects of Timed and Untimed Testing Conditions on the Reading Comprehension Performance of Adults with Reading Disabilities. Special Issue on Reading Comprehension ? Part II

ERIC Educational Resources Information Center

Lesaux, Nonie K.; Pearson, M. Rufina; Siegel, Linda S.

2006-01-01

This study examined the effects of extra time on the reading comprehension performance of a heterogeneous group of adults with reading disabilities. Sixty-four adults participated. A clinic that assesses learning disabilities identified 22 as reading disabled, and 42 as normal readers. The 64 adults took a reading comprehension test under both…

The effect of selective photosuppression of sensitized pathogenic microflora: Part II. Experimental validation on animals

NASA Astrophysics Data System (ADS)

Masychev, Viktor I.; Risovannaya, Olga N.

2005-03-01

Results of in vivo experiments have shown the maximum effectiveness of combined use of photo sensitizer 0,1% gel Radachlorine simultaneously with continuous and super pulse low energy irradiation of the diode laser with energy density 400 J/cm2, and power 1W. Given parameters have lead to complete elimination of Streptococcus pyogenes from inflammation foci in oral cavity of experimental animals.

Structures and Properties of Polyurethanes. Part II,

DTIC Science & Technology

1979-03-23

effect was observed for polymethyl methacrylate (222, 2721. The polyol, which contain fluorine , decrease adhesion, in spite DOC = 79011112 PAGE S4% of...small differences in the hardness of films on the basis of the fluorine -bearing polyol and generally accepted polyol. Is investigated the etfect ot...polyurethane, to rigid surface. DOC 79011112 P A * S The effect of the solvent, utilized for obtaining the varnish , on adhesion is investigated in

The mental health sector and the social sciences in post- World War II USA. Part 2: The impact of federal research funding and the drugs revolution.

PubMed

Scull, Andrew

2011-09-01

The second of two linked papers examining the interactions of psychiatry and the social sciences since World War II examines the role of NIMH on these disciplines. It analyses the effects of the prominence and the decline of psychoanalysis, and the impact of the psychotropic drugs revolution and the associated rise of biological psychiatry on relations between psychiatry and clinical psychology; and it explores the changing relationships between psychiatry and sociology, from collaboration to conflict to mutual disdain.

Medical Devices; Immunology and Microbiology Devices; Classification of the Device To Detect and Measure Non-Microbial Analyte(s) in Human Clinical Specimens To Aid in Assessment of Patients With Suspected Sepsis. Final order.

PubMed

2017-10-24

The Food and Drug Administration (FDA or we) is classifying the device to detect and measure non-microbial analyte(s) in human clinical specimens to aid in assessment of patients with suspected sepsis into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the device to detect and measure non-microbial analyte(s) in human clinical specimens to aid in assessment of patients with suspected sepsis's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

Formation of tyrosine radicals in photosystem II under far-red illumination.

PubMed

Ahmadova, Nigar; Mamedov, Fikret

2018-04-01

Photosystem II (PS II) contains two redox-active tyrosine residues on the donor side at symmetrical positions to the primary donor, P 680 . Tyr Z , part of the water-oxidizing complex, is a preferential fast electron donor while Tyr D is a slow auxiliary donor to P 680 + . We used PS II membranes from spinach which were depleted of the water oxidation complex (Mn-depleted PS II) to study electron donation from both tyrosines by time-resolved EPR spectroscopy under visible and far-red continuous light and laser flash illumination. Our results show that under both illumination regimes, oxidation of Tyr D occurs via equilibrium with Tyr Z • at pH 4.7 and 6.3. At pH 8.5 direct Tyr D oxidation by P 680 + occurs in the majority of the PS II centers. Under continuous far-red light illumination these reactions were less effective but still possible. Different photochemical steps were considered to explain the far-red light-induced electron donation from tyrosines and localization of the primary electron hole (P 680 + ) on the Chl D1 in Mn-depleted PS II after the far-red light-induced charge separation at room temperature is suggested.

40 CFR 52.1078 - Extensions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... second generation On-board Diagnostics (OBD-II) equipped motor vehicles as part of its inspection and...-II checks (for 1996-and-newer OBD-II equipped vehicles) as an element of the Commonwealth's I/M...

Student Performance on the NBME Part II Subtest and Subject Examination in Obstetrics-Gynecology.

ERIC Educational Resources Information Center

Metheny, William P.; Holzman, Gerald B.

1988-01-01

Comparison of the scores of 342 third-year medical students on the National Board of Medical Examiners subject examination and the Part II subtest on obstetrics-gynecology found significantly better performance on the former, suggesting a need to interpret the scores differently. (Author/MSE)

Analysis of Vietnamization: Summary and Evaluation

DTIC Science & Technology

1973-11-01

Ellsberg, Daniel . Some Lessons from Failure in Vietnam, P-4036. Santa Monica: The RAND Corp., July 1969. Fulbright, J. William (ed.). The Vietnam...34 Chira and North Vietnam: Two Revolutionary Paths, " Part I, Current Scene, Vol. IX, No. II (Nov 7, 1971), Part II, Current Scene. Vol. IX, No. IZ (Doc 7

Neural representation of objects in space: a dual coding account.

PubMed Central

Humphreys, G W

1998-01-01

I present evidence on the nature of object coding in the brain and discuss the implications of this coding for models of visual selective attention. Neuropsychological studies of task-based constraints on: (i) visual neglect; and (ii) reading and counting, reveal the existence of parallel forms of spatial representation for objects: within-object representations, where elements are coded as parts of objects, and between-object representations, where elements are coded as independent objects. Aside from these spatial codes for objects, however, the coding of visual space is limited. We are extremely poor at remembering small spatial displacements across eye movements, indicating (at best) impoverished coding of spatial position per se. Also, effects of element separation on spatial extinction can be eliminated by filling the space with an occluding object, indicating that spatial effects on visual selection are moderated by object coding. Overall, there are separate limits on visual processing reflecting: (i) the competition to code parts within objects; (ii) the small number of independent objects that can be coded in parallel; and (iii) task-based selection of whether within- or between-object codes determine behaviour. Between-object coding may be linked to the dorsal visual system while parallel coding of parts within objects takes place in the ventral system, although there may additionally be some dorsal involvement either when attention must be shifted within objects or when explicit spatial coding of parts is necessary for object identification. PMID:9770227

Safety and Efficacy of Rotigotine for Treating Parkinson's Disease: A Meta-Analysis of Randomised Controlled Trials.

PubMed

Chen, Fei; Jin, Lingjing; Nie, Zhiyu

2017-01-01

We aimed to comprehensively analyse the safety and efficiency of rotigotine for treating Parkinson's disease (PD). We conducted systematic literature searches of Cochrane library, PubMed and Embase databases up to April 2016, with 'Rotigotine', 'Parkinson Disease ' and 'Parkinson's disease' as key searching terms. Outcomes, including Unified Parkinson's Disease Rating Scale (UPDRS) Part III and Part II scores, 'off' time, adverse events (AEs), serious AEs and discontinuation because of AEs, were compared between rotigotine and placebo groups under a fixed or random effect model. For dichotomous and continuous data, risk ratio (RR) and weighted mean difference with their corresponding 95% confidence intervals (95% CIs) were taken as the effect sizes to calculate merged results. Twelve eligible studies were included. For patients with early or advanced PD, rotigotine could significantly improve UPDRS Part III and Part II scores (p < 0.001) and it had significantly higher incidence of AEs than the placebo (p < 0.001). Regarding discontinuation because of AEs, rotigotine showed a significant advantage over placebo in patients with early PD, whereas the overall result demonstrated no statistically significant difference between the groups. Rotigotine can improve daily living and motor ability of patients with PD, although it has higher incidence of AEs. Rotigotine might be more appropriate for patients with advanced PD than for those with early PD. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells.

PubMed

Guo, Deng-Fu; Tardif, Valerie; Ghelima, Karin; Chan, John S D; Ingelfinger, Julie R; Chen, XiangMei; Chenier, Isabelle

2004-05-14

Angiotensin II stimulates cellular hypertrophy in cultured vascular smooth muscle and renal proximal tubular cells. This effect is believed to be one of earliest morphological changes of heart and renal failure. However, the precise molecular mechanism involved in angiotensin II-induced hypertrophy is poorly understood. In the present study we report the isolation of a novel angiotensin II type 1 receptor-associated protein. It encodes a 531-amino acid protein. Its mRNA is detected in all human tissues examined but highly expressed in the human kidney, pancreas, heart, and human embryonic kidney cells as well as rat vascular smooth muscle and renal proximal tubular cells. Protein synthesis and relative cell size analyzed by flow cytometry studies indicate that overexpression of the novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. In contrast, the hypertrophic effects was reversed in renal proximal tubular cell lines expressing the novel gene in the antisense orientation and its dominant negative mutant, which lacks the last 101 amino acids in its carboxyl-terminal tail. The hypertrophic effects are at least in part mediated via protein kinase B activation or cyclin-dependent kinase inhibitor, p27(kip1) protein expression level in vascular smooth muscle, and renal proximal tubular cells. Moreover, angiotensin II could not stimulate cellular hypertrophy in renal proximal tubular cells expressing the novel gene in the antisense orientation and its mutant. These findings may provide new molecular mechanisms to understand hypertrophic agents such as angiotensin II-induced cellular hypertrophy.

Short-term effects of air pollution on respiratory morbidity at Rio de Janeiro--Part II: health assessment.

PubMed

Sousa, S I V; Pires, J C M; Martins, E M; Fortes, J D N; Alvim-Ferraz, M C M; Martins, F G

2012-08-01

The effects of air pollution on health have been studied worldwide. Given that air pollution triggers oxidative stress and inflammation, it is plausible that high levels of air pollutants cause higher number of hospitalisations. This study aimed to assess the impact of air pollution on the emergency hospitalisation for respiratory disease in Rio de Janeiro, Brazil. The study was divided in two parts: Part I specifically addressing the air pollution assessment and Part II addressing the health assessment. Accordingly, this Part II aimed to estimate the association between the concentrations of PM₁₀, SO₂ and CO observed in Rio de Janeiro and the number of emergency hospitalisations at a central hospital due to respiratory diseases. The pollutant concentrations were measured at two different sites in Rio de Janeiro, but the excess relative risks were calculated based on the concentrations observed at one of the sites, where limits were generally exceeded more frequently, between September 2000 and December 2005. A time series analysis was performed using the number of hospitalisations, divided in three categories (children until 1 year old, children aged between 1 and 5 years old and elderly with 65 years old or more) as independent variable, the concentrations of pollutants as dependent variables and temperature, relative humidity, long term trend, and seasonality as confounders. Data were analysed using generalised additive models with smoothing for some of the dependent variables. Results showed an excess risk of hospitalisation for respiratory disease higher than 2% per 10 μg m⁻³ increase in PM₁₀ concentrations for children under 5 years old, of 2% per 10 μg m⁻³ increase in SO₂ for elderly above 65 years old and around 0.1% per 10 μg m⁻³ increase in CO for children under 1 year and elderly. Other studies have found associations that are in agreement with the results achieved in this study. The study suggests that the ambient levels of air pollutants experienced in Rio de Janeiro between 2000 and 2005 were linked to the number of hospitalisations for respiratory diseases among children and elderly. Copyright © 2012 Elsevier Ltd. All rights reserved.

Equal channel angular extrusion for bulk processing of Fe–Co–2V soft magnetic alloys, part II: Texture analysis and magnetic properties

DOE PAGES

Kustas, Andrew B.; Michael, Joseph R.; Susan, Don F.; ...

2018-06-04

In Part I, equal channel angular extrusion (ECAE) was demonstrated as a novel, simple-shear deformation process for producing bulk forms of the low ductility Fe–Co–2V (Hiperco 50A®) soft ferromagnetic alloy with refined grain sizes. Microstructures and mechanical properties were discussed. In this Part II contribution, the crystallographic textures and quasi-static magnetic properties of ECAE-processed Hiperco were characterized. The textures were of a simple-shear character defined by partial {110} and <111> fibers inclined relative to the extrusion direction, in agreement with the expectations for simple-shear deformation textures of BCC metals. These textures were observed throughout all processing conditions and only slightlymore » reduced in intensity by subsequent recrystallization heat treatments. Characterization of the magnetic properties revealed a lower coercivity and higher permeability for ECAE-processed Hiperco specimens relative to the conventionally processed and annealed Hiperco bar. In conclusion, the effects of the resultant microstructure and texture on the coercivity and permeability magnetic properties are discussed.« less

Equal channel angular extrusion for bulk processing of Fe–Co–2V soft magnetic alloys, part II: Texture analysis and magnetic properties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kustas, Andrew B.; Michael, Joseph R.; Susan, Don F.

In Part I, equal channel angular extrusion (ECAE) was demonstrated as a novel, simple-shear deformation process for producing bulk forms of the low ductility Fe–Co–2V (Hiperco 50A®) soft ferromagnetic alloy with refined grain sizes. Microstructures and mechanical properties were discussed. In this Part II contribution, the crystallographic textures and quasi-static magnetic properties of ECAE-processed Hiperco were characterized. The textures were of a simple-shear character defined by partial {110} and <111> fibers inclined relative to the extrusion direction, in agreement with the expectations for simple-shear deformation textures of BCC metals. These textures were observed throughout all processing conditions and only slightlymore » reduced in intensity by subsequent recrystallization heat treatments. Characterization of the magnetic properties revealed a lower coercivity and higher permeability for ECAE-processed Hiperco specimens relative to the conventionally processed and annealed Hiperco bar. In conclusion, the effects of the resultant microstructure and texture on the coercivity and permeability magnetic properties are discussed.« less

Periodontal soft tissue root coverage procedures: a systematic review from the AAP Regeneration Workshop.

PubMed

Chambrone, Leandro; Tatakis, Dimitris N

2015-02-01

This paper aims to create a "bridge" between research and practice by developing a practical, extensive, and clinically relevant study that translates evidence-based findings on soft tissue root coverage (RC) of recession-type defects to daily clinical practice. This review is prepared in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement based on the proposed focused questions. A literature search with no restrictions regarding status or the language of publication was performed for MEDLINE and EMBASE databases up to and including June 2013. Systematic reviews (SRs), randomized clinical trials, controlled clinical trials, case series, and case reports evaluating recession areas that were treated by means of RC procedures were considered eligible for inclusion through the three parts of the study (part I, an overview of the base of SRs; part II, an alternative random-effects meta-analyses on mean percentage of RC and sites exhibiting complete RC; and part III, an SR of non-randomized trials exploring other conditions not extensively evaluated by previous SRs). Data on Class I, II, III, and IV recessions, type of histologic attachment achieved with treatment, recipient- and donor-site anatomic characteristics, smoking-related outcomes, root surface conditions, tooth type and location, long-term effectiveness outcomes, unusual conditions that may be reported during conventional daily practice, and patient-centered outcomes were assessed as well. Of the 2,456 potentially eligible trials, 234 were included. Data on Class I, II, III, and IV gingival recessions, histologic attachment achieved after treatment, recipient- and donor-site anatomic characteristics, smoking-related outcomes, root surface conditions/biomodification, tooth type and location, long-term effectiveness outcomes and unusual conditions that may be reported during conventional daily practice, and patient-centered outcomes (i.e., esthetic, visual analog scale, complications, hypersensitivity, patients perceptions) were assessed. Subepithelial connective tissue (CT)-based procedures and coronally advanced flap plus acellular dermal matrix grafts, enamel matrix derivative, or collagen matrix led to the best improvements of recession depth, clinical attachment level (CAL) gain, and keratinized tissue (KT). Some conditions, such as smoking and use of magnification, may affect RC outcomes. All RC procedures can provide significant reduction in recession depth and CAL gain for Miller Class I and II recession-type defects. Subepithelial CT graft-based procedures provided the best outcomes for clinical practice because of their superior percentages of mean and complete RC, as well as significant increase of KT.

Colloidal systems and interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ross, S.; Morrison, E.D.

1988-01-01

This book is an excellent, four-part introductory text and sourcebook for those who want to acquire a quick background in , or brush up on, the physical properties and behavior of colloidal dispersions and interfaces. Part I covers properties of particles and techniques for determining particle size and surface area. Part II concentrates on the properties of interfaces, with brief subsections on insoluble monolayers, surface active solutes in aqueous and non-aqueous media, and the thermodynamics of adsorption at interfaces. Part III considers attractive and repulsive interactions, colloid stability (DLVO theory), and kinetics of coagulation. Part IV applies these concepts tomore » emulsions, foams, and suspensions. The sections on colloid rheology, interfacial tensions, Marangoni effects, and calculation of Hamaker constants are particularly good, as are Part IV and the numerous examples of practical applications used throughout the book to illustrate the concepts.« less

Impact of a commercial glyphosate formulation on adsorption of Cd(II) and Pb(II) ions on paddy soil.

PubMed

Divisekara, T; Navaratne, A N; Abeysekara, A S K

2018-05-01

Use of glyphosate as a weedicide on rice cultivation has been a controversial issue in Sri Lanka, due to the hypothesis that the metal complexes of commercial glyphosate is one of the causative factors of Chronic Kidney Disease of unknown aetiology (CKDu) prevalent in some parts of Sri Lanka. The effect of commercial glyphosate on the adsorption and desorption of Cd(II) and Pb(II) ions on selective paddy soil studied using batch experiments, over a wide concentration range, indicates that the Langmuir adsorption isotherm model is obeyed at low initial metal ion concentrations while the Freundlich adsorption isotherm model obeys at high metal ion concentrations in the presence and absence of glyphosate. For all cases, adsorption of both Cd(II) and Pb(II) ions obeys pseudo second order kinetics, suggesting that initial adsorption is a chemisorption process. In the presence of glyphosate formulation, the extent of adsorption of Cd(II) and Pb(II) ions on soil is decreased, while their desorption is increased at high concentrations of glyphosate. Low concentrations of glyphosate formulation do not significantly affect the desorption of metal ions from soil. Reduction of adsorption leads to enhance the concentration of Cd(II) and Pb(II) ions in the aqueous phase when in contact with soil. Copyright © 2018 Elsevier Ltd. All rights reserved.

Department of Defense Index of Specifications and Standards. Part 1. Alphabetical Listing

DTIC Science & Technology

1989-07-01

the Basic DODISS Part II. PART II, Numerical Listing reflects all active documents in document number sequence within document type. The alphabetic...NPFC 106) 5801 Tabor Avenue P ’ - elphia, PA 19120 "The use Index is mandatory on all military activities . This mandatory provision i as thiat the...Class, is also available as follows: Military Activities : Commanding Officer Naval Publications and Forms Center (ATTN: NPODS) 5801 Tabor Avenue

Nursing Care of Patients Undergoing Chemotherapy Desensitization: Part II.

PubMed

Jakel, Patricia; Carsten, Cynthia; Carino, Arvie; Braskett, Melinda

2016-04-01

Chemotherapy desensitization protocols are safe, but labor-intensive, processes that allow patients with cancer to receive medications even if they initially experienced severe hypersensitivity reactions. Part I of this column discussed the pathophysiology of hypersensitivity reactions and described the development of desensitization protocols in oncology settings. Part II incorporates the experiences of an academic medical center and provides a practical guide for the nursing care of patients undergoing chemotherapy desensitization.
.

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit E: Choosing the Type of Ownership. Research and Development Series No. 194 B-5.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is establishing a business. Unit E focuses on the three major types of…

Bases of Classification of Geometric Concepts Used by Children of Varying Characteristics. Report from the Project on Situational Variables and Efficiency of Concept Learning. Part II.

ERIC Educational Resources Information Center

Wiviott, Suzanne Pasch

This document, Part II of a two-part study, is the summary chapter of a report which sought to ascertain the relationship of grade level, achievement level, sex, and method of presentation to the various bases by which children classify geometric concepts. Two tasks, administered consecutively to 96 subjects in grades five, eight, and eleven,…

Starting a hospital-based home health agency: Part II--Key success factors.

PubMed

Montgomery, P

1993-09-01

In Part II of a three-part series, the financial, technological and legislative issues of a hospital-based home health-agency are discussed. Beginning a home healthcare service requires intensive research to answer key environmental and operational questions--need, competition, financial projections, initial start-up costs and the impact of delayed depreciation. Assessments involving technology, staffing, legislative and regulatory issues can help project service volume, productivity and cost-control.

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit F: How to Finance the Business. Research and Development Series No. 194 B-6.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is establishing a business. Unit F focuses on financing the business. It…

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit B: Where to Locate the Business. Research and Development Series No. 194 B-2.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is on establishing a business. Unit B focuses on choosing a business…

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit D: Government Regulations and Small Businesses. Research and Development Series No. 194 B-4.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is establishing a business. Unit D focuses on business regulations at…

PACE. A Program for Acquiring Competence in Entrepreneurship. Part II: Becoming an Entrepreneur. Unit C: Legal Issues and Small Business. Research and Development Series No. 194 B-3.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This three-part curriculum for entrepreneurship education is primarily for postsecondary level, including four-year colleges and adult education, but it can be adapted for special groups or vocational teacher education. The emphasis of the seven instructional units in Part II is establishing a business. Unit C focuses on legal issues that affect…

Tagmatization in Stomatopoda - reconsidering functional units of modern-day mantis shrimps (Verunipeltata, Hoplocarida) and implications for the interpretation of fossils.

PubMed

Haug, Carolin; Sallam, Wafaa S; Maas, Andreas; Waloszek, Dieter; Kutschera, Verena; Haug, Joachim T

2012-11-14

We describe the tagmatization pattern of the anterior region of the extant stomatopod Erugosquilla massavensis. For documentation we used the autofluorescence capacities of the specimens, resulting in a significant contrast between sclerotized and membranous areas. The anterior body region of E. massavensis can be grouped into three tagmata. Tagma I, the sensorial unit, comprises the segments of the eyes, antennules and antennae. This unit is set-off anteriorly from the posterior head region. Ventrally this unit surrounds a large medial sclerite, interpreted as the anterior part of the hypostome. Dorsally the antennular and antennal segments each bear a well-developed tergite. The dorsal shield is part of tagma II, most of the ventral part of which is occupied in the midline by the large, partly sclerotized posterior part of a complex combining hypostome and labrum. Tagma II includes three more segments behind the labrum, the mandibular, maxillulary and maxillary segments. Tagma III includes the maxillipedal segments, bearing five pairs of sub-chelate appendages. The dorsal sclerite of the first of these tagma-III segments, the segment of the first maxillipeds, is not included in the shield, so this segment is not part of tagma II as generally thought. The second and third segments of tagma III form a unit dorsally and ventrally. The tergites of the segments of tagma III become progressively larger from the anterior to the posterior, possibly resulting from a paedomorphic effect during evolution, which caused this reversed enlargement. The described pattern of tagmosis differs from current textbook knowledge. Therefore, our re-description of the anterior body area of stomatopods is of considerable impact for understanding the head evolution of Stomatopoda. Likewise, it has a bearing upon any comparisons with fossil stomatopods, as mainly sclerotized areas are fossilized, and, on a wider scale, upon larger-scale comparisons with other malacostracans and eucrustaceans in general.

Functional role of inorganic trace elements in angiogenesis-Part II: Cr, Si, Zn, Cu, and S.

PubMed

Saghiri, Mohammad Ali; Asatourian, Armen; Orangi, Jafar; Sorenson, Christine M; Sheibani, Nader

2015-10-01

Trace elements play critical roles in angiogenesis events. The effects of nitrogen, iron, selenium, phosphorus, gold, and calcium were discussed in part I. In part II, we evaluated the effect of chromium, silicon, zinc, copper, and sulfur on different aspects of angiogenesis, with critical roles in healing and regeneration processes, and undeniable roles in tumor growth and cancer therapy. This review is the second of series that serves as an overview of the role of inorganic elements in regulation of angiogenesis and vascular function. The methods of exposure, structure, mechanism, and potential activity of these trace elements are briefly discussed. An electronic search was performed on the role of these trace elements in angiogenesis from January 2005 to April 2014. The recent aspects of the relationship between five different trace elements and their role in regulation of angiogenesis, and homeostasis of pro- and anti-angiogenic factors were assessed. Many studies have investigated the effects and importance of these elements in angiogenesis events. Both stimulatory and inhibitory effects on angiogenesis are observed for the evaluated elements. Chromium can promote angiogenesis in pathological manners. Silicon as silica nanoparticles is anti-angiogenic, while in calcium silicate extracts and bioactive silicate glasses promote angiogenesis. Zinc is an anti-angiogenic agent acting on important genes and growth factors. Copper and sulfur compositions have pro-angiogenic functions by activating pro-angiogenic growth factors and promoting endothelial cells migration, growth, and tube formation. Thus, utilization of these elements may provide a unique opportunity to modulate angiogenesis under various setting. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

ANG II is required for optimal overload-induced skeletal muscle hypertrophy

NASA Technical Reports Server (NTRS)

Gordon, S. E.; Davis, B. S.; Carlson, C. J.; Booth, F. W.

2001-01-01

ANG II mediates the hypertrophic response of overloaded cardiac muscle, likely via the ANG II type 1 (AT(1)) receptor. To examine the potential role of ANG II in overload-induced skeletal muscle hypertrophy, plantaris and/or soleus muscle overload was produced in female Sprague-Dawley rats (225-250 g) by the bilateral surgical ablation of either the synergistic gastrocnemius muscle (experiment 1) or both the gastrocnemius and plantaris muscles (experiment 2). In experiment 1 (n = 10/group), inhibiting endogenous ANG II production by oral administration of an angiotensin-converting enzyme (ACE) inhibitor during a 28-day overloading protocol attenuated plantaris and soleus muscle hypertrophy by 57 and 96%, respectively (as measured by total muscle protein content). ACE inhibition had no effect on nonoverloaded (sham-operated) muscles. With the use of new animals (experiment 2; n = 8/group), locally perfusing overloaded soleus muscles with exogenous ANG II (via osmotic pump) rescued the lost hypertrophic response in ACE-inhibited animals by 71%. Furthermore, orally administering an AT(1) receptor antagonist instead of an ACE inhibitor produced a 48% attenuation of overload-induced hypertrophy that could not be rescued by ANG II perfusion. Thus ANG II may be necessary for optimal overload-induced skeletal muscle hypertrophy, acting at least in part via an AT(1) receptor-dependent pathway.

Single Event Effects Test Results for the Actel ProASIC Plus and Altera Stratix-II Field Programmable Gate Arrays

NASA Technical Reports Server (NTRS)

Allen, Gregory R.; Swift, Gary M.

2006-01-01

This work describes radiation testing of Actel's ProASIC Plus and Altera's Stratix-II FPGAs. The Actel Device Under Test (DUT) was a ProASIC Plus APA300-PQ208 nonvolatile, field reprogrammable device which is based on a 0.22micron flash-based LVCMOS technology. Limited investigation has taken place into flash based FPGA technologies, therefore this test served as a preliminary reference point for various SEE behaviors. The Altera DUT was a Stratix-II EP2S60F1020C4. Single Event Upset (SEU) and Single Event Latchup (SEL) were the focus of these studies. For the Actel, a latchup test was done at an effective LET of 75.0 MeV-sq cm/mg at room temperature, and no latchup was detected when irradiated to a total fluence of 1 x 10(exp 7) particles/sq cm. The Altera part was shown to latchup at room temperature.

Can nerve regeneration on an artificial nerve conduit be enhanced by ethanol-induced cervical sympathetic ganglion block?

PubMed Central

Sunada, Katsuhisa; Shigeno, Keiji; Nakada, Akira; Honda, Michitaka; Nakamura, Tatsuo

2017-01-01

This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments—in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; part II involved evaluation of the effect of CSGB by ethanol injection on inferior alveolar nerve (IAN) repair using polyglycolic acid-collagen tubes. In part I, seven Beagles were administered left CSGB by injection of 99.5% ethanol under direct visualization by means of thoracotomy, and changes in oral mucosal blood flow in the mental region and nasal skin temperature were evaluated. The increase in blood flow on the left side lasted for 7 weeks, while the increase in average skin temperature lasted 10 weeks on the left side and 3 weeks on the right. In part II, fourteen Beagles were each implanted with a polyglycolic acid-collagen tube across a 10-mm gap in the left IAN. A week after surgery, seven of these dogs were administered CSGB by injection of ethanol. Electrophysiological findings at 3 months after surgery revealed significantly higher sensory nerve conduction velocity and recovery index (ratio of left and right IAN peak amplitudes) after nerve regeneration in the reconstruction+CSGB group than in the reconstruction-only group. Myelinated axons in the reconstruction+CSGB group were greater in diameter than those in the reconstruction-only group. Administration of CSGB with ethanol resulted in improved nerve regeneration in some IAN defects. However, CSGB has several physiological effects, one of which could possibly be the long-term increase in adjacent blood flow. PMID:29220373

Dynamical response of the Galileo Galilei on the ground rotor to test the equivalence principle: Theory, simulation, and experiment. I. The normal modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Comandi, G.L.; Chiofalo, M.L.; Toncelli, R.

Recent theoretical work suggests that violation of the equivalence principle might be revealed in a measurement of the fractional differential acceleration {eta} between two test bodies-of different compositions, falling in the gravitational field of a source mass--if the measurement is made to the level of {eta}{approx_equal}10{sup -13} or better. This being within the reach of ground based experiments gives them a new impetus. However, while slowly rotating torsion balances in ground laboratories are close to reaching this level, only an experiment performed in a low orbit around the Earth is likely to provide a much better accuracy. We report onmore » the progress made with the 'Galileo Galilei on the ground' (GGG) experiment, which aims to compete with torsion balances using an instrument design also capable of being converted into a much higher sensitivity space test. In the present and following articles (Part I and Part II), we demonstrate that the dynamical response of the GGG differential accelerometer set into supercritical rotation-in particular, its normal modes (Part I) and rejection of common mode effects (Part II)-can be predicted by means of a simple but effective model that embodies all the relevant physics. Analytical solutions are obtained under special limits, which provide the theoretical understanding. A simulation environment is set up, obtaining a quantitative agreement with the available experimental data on the frequencies of the normal modes and on the whirling behavior. This is a needed and reliable tool for controlling and separating perturbative effects from the expected signal, as well as for planning the optimization of the apparatus.« less

Typewriting Syllabus: Part II: Modules. 1976 Revision.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of Occupational and Career Curriculum Development.

The document is the second of a two-part set on typewriting and focuses on the nine modules of instruction. The nine modules are: (1) keyboard mastery and skill development, (2) basic typewriting competencies, (2a) personal use typewriting, (3) introduction to office typewriting I, (4) introduction to office typewriting II, (5) intermediate office…

An analysis of the lumber planning process: Part II

Treesearch

Peter Koch

1956-01-01

This study is part II of an investigation pertaining to the peripheral-milling process of planing lumber. Some relationships were determined between cutterhead horsepower and various combinations of specimen, cutterhead, and feed factors. Power demand curves were interpreted through comparison with simultaneously taken one micro-second photos of the forming chips....

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2013 CFR

2013-10-01

... plan in writing 90 days before the intended date of the termination. (ii) The Part D plan sponsor... sponsor; (B) The Part D plan sponsor experiences financial difficulties so severe that its ability to make...)(4) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

77 FR 60743 - Proposed Collection; Comment Request for Schedule F, Part II and III (Form 1040)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

... Farming. DATES: Written comments should be received on or before December 3, 2012 to be assured of... Loss From Farming. OMB Number: 1545-1976. Form Number: Schedule F, Part II and III (Form 1040... collection. Affected Public: Businesses and other for-profit organizations, Farming. Estimated Number of...

Retrofit of waste-to-energy facilities equipped with electrostatic precipitators. Volume II: Field and laboratory reports, Part 2 of 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rigo, H.G.; Chandler, A.J.

Volume II (part 2 of 2) of ''Retrofit of Waste-to-energy Facilities Equipped with Electrostatic Precipitators'' contains the field and laboratory reports, including: (1) field reports, (2) analytic laboratory reports, (3) chain of custody forms, and (4) TCLP laboratory reports.

Retrofit of waste-to-energy facilities equipped with electrostatic precipitators. Volume II: Field and Laboratory Reports, Part 1 of 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rigo, H.G.; Chandler, A.J.

1996-04-01

Volume II (part 1 of 2) of ''Retrofit of Waste-to-energy Facilities Equipped with Electrostatic Precipitators'' contains the documentation and raw data, including: (1) field reports, (2) analytic laboratory reports, (3) chain of custody forms, and (4) TCLP laboratory reports.

7 CFR 1962.49 - Civil and criminal cases.

Code of Federal Regulations, 2012 CFR

2012-01-01

... action necessary to report the information required by Part II of Form FmHA or its successor agency under... involved, would be adversely affected if suit were not filed; and (ii) Collection of a substantial part of... accordance with paragraph (c)(3) of this section. (1) County Office actions. Forms FmHA or its successor...

Effect of Service Environment on Composite Materials

DTIC Science & Technology

1980-08-01

AGARC -CP-288 . z AGARD Conference Procee•dings No.288 Effect of Service Environment on Composite Materials M1TflIBInj4 STATE 9s~k 7- II LLU...ORGANISATION DU TRAITE DE L’ATLANTI )UE NOR3) AGARD Conference Proceedings 1, o.288 EFFECT OF SERVICE ENVIRONM ENT ONj I COMPOSITE MATERIALS --- I... composites soumis aux divers types d’agressions que l’on recouvre aujourd’hui du vocable d’...environnement". On doit admettre que cette revue 6tait part

A phase I/II clinical trial for the hybrid of intracavitary and interstitial brachytherapy for locally advanced cervical cancer.

PubMed

Murakami, Naoya; Kato, Shingo; Nakano, Takashi; Uno, Takashi; Yamanaka, Takeharu; Sakurai, Hideyuki; Yoshimura, Ryoichi; Hiratsuka, Junichi; Kuroda, Yuki; Yoshio, Kotaro; Itami, Jun

2016-08-17

This paper describes about a study protocol of phase I/II multicenter prospective clinical trial evaluating the feasibility and efficacy of the hybrid of intracavitary and interstitial brachytherapy (HBT) for locally advanced uterine cervical cancer patients. Patients with histologically confirmed FIGO stage IB2, IIA2, IIB, and IIIB uterine cervical carcinoma width of which is larger than 5 cm assessed by MRI will be entered to this clinical trial. Protocol therapy is 30-30.6 Gy in 15-17 fractions of whole pelvic radiotherapy concurrent with weekly CDDP (40 mg/m(2)), followed by 24 Gy in 4 fractions of HBT and central shield EBRT up to 50-50.4 Gy in 25-28 fractions. Tumor width is assessed again within one week before the first HBT and if the tumor width is larger than 4 cm, patients proceed to the secondary registration. In phase I section, feasibility of this will be investigated. If less than 10 % out of 20 patients experienced greater than grade 3 acute non-hematologic adverse effects, the study proceeds to phase II part. In phase II part a total of 55 patients will be accrued and the efficacy of the HBT will be investigated comparing with historical control data. If the lower margin of 90 % confidence interval of the 2-year pelvic progression-free survival of the HBT trial is higher than 64 %, the HBT is considered to be more effective than conventional ICBT. The aim of this study is to demonstrate the feasibility and efficacy of the HBT for locally advanced cervical cancer. This trial will clarify the indication, feasibility, and efficacy of this new technique. UMIN000019081 ; Registration date: 2015/9/30.

Effect of N-acetylcysteine on the accuracy of the prothrombin time assay of plasma coagulation factor II+VII+X activity in subjects infused with the drug. Influence of time and temperature.

PubMed

Thorsen, Sixtus; Teisner, Ane; Jensen, Søren Astrup; Philips, Malou; Dalhoff, Kim; Bendtsen, Flemming

2009-01-01

The prothrombin time (PT) assay of factor II+VII+X activity is an important predictor of liver damage in paracetamol poisoned patients. It complicates interpretation of results that the antidote, acetylcysteine (NAC) depresses this activity. The aim was to investigate if NAC influences the accuracy of the plasma PT assay. The accuracy of Nycotest PT was studied using plasma added NAC in vitro and plasma from subjects infused with NAC. The latter results were compared with those obtained by analysis of PT by CoaguChek S. Therapeutic NAC concentrations added to plasma in vitro decreased factor II+VII+X activity at 37 degrees C in a time-dependent manner. This effect was quenched at temperatures <24 degrees C. Activity lost at 37 degrees C could partly be recovered by subsequent incubation at 5 or 20 degrees C. Incubation at 37 degrees C prior to assay led to a significant additional depression of factor II+VII+X activity in plasma from subjects infused with NAC during the first 3h of infusion indicating that it contained reactive NAC. The risk that this NAC interfered with the accuracy of the PT assay was considered minimal with samples stored below 24 degrees C. This was supported by similarity of results obtained by analysis of appropriately stored plasma and simultaneously drawn blood by CoaguChek S. Residual reactive NAC does not interfere with the accuracy of the PT assay of plasma stored below 24 degrees C, but NAC-induced loss in activity at 37 degrees C may be partly recovered during subsequent storage below 24 degrees C.

Feedback Flow Control for a Pitching Turret (Part II) (POSTPRINT)

DTIC Science & Technology

2010-01-01

FL, 2007. 2S. Gordeyev , T. E. Hayden, and E. J. Jumper , “Aero-Optical and Flow Measurements Over a Flat-Windowed Turret,” AIAA Journal, Vol. 45, No...public release; distribution unlimited. 13. SUPPLEMENTARY NOTES Conference presentation published in the Proceedings of the 48th AIAA Aerospace...Compressible effects are not present at this speed, but systems for controlling velocity fluctuations in incompressible flows will be effective in controlling

Faigue Avoidance Scheduling Tool (FAST) Phase II SBIR Final Report, Part 1

DTIC Science & Technology

2006-05-01

treatment . This lead us to modify the SAFTE model such that it could predict the slow recovery effects uncovered in the SDR Study. The SAFTE model was...features making the model more accessible and useful to users. The transmeridian phase shift algorithm was added to accommodate aircrews crossing ...sleep treatment . This lead us to modify the SAFTE model such that it could predict the slow recovery effects uncovered in the

BCS and generalized BCS superconductivity in relativistic quantum field theory. II. Numerical calculations

NASA Astrophysics Data System (ADS)

Ohsaku, Tadafumi

2002-08-01

We solve numerically various types of the gap equations developed in the relativistic BCS and generalized BCS framework, presented in part I of this paper. We apply the method for not only the usual solid metal but also other physical systems by using homogeneous fermion gas approximation. We examine the relativistic effects on the thermal properties and the Meissner effect of the BCS and generalized BCS superconductivity of various cases.

Grid Resolution Effects on LES of a Piloted Methane-Air Flame

DTIC Science & Technology

2009-05-20

respectively. In the LES momen- tum equation , Eq.(3), the Smagorinsky model is used to obtain the deviatoric part of the unclosed SGS stress τi j... accurately predicted from integra- tion of their LES evolution equations ; and (ii), the flamelet parametrization should adequately approximate the... effect of the complex small-scale turbulence/chemistry interactions is modeled in an affordable way by a combustion model. A question of how a particular

Nuclear Weapon Effect Research at PSR (Pacific-Sierra Research Corporation) - 1983. Symptomatology of Acute Radiation Effects in Humans after Exposure to Doses of 75 to 4500 Rads (cGy) Free-in-Air

DTIC Science & Technology

1984-08-31

subsequently published as DNA-TR-81-237 and Chap. II of PSR Report 1241 ). George H. Anno, Acute Radiation Response in lirwans: InJormaZ Conrients by...Radiation Accidents: Medical Aspects of Neutron and Gcama-Ray Exposures, Oak Ridge National Laboratory, Oak Ridge, Tennessee, Report ORNL -2748, Part B

The PIP-II Conceptual Design Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ball, M.; Burov, A.; Chase, B.

2017-03-01

The Proton Improvement Plan-II (PIP-II) encompasses a set of upgrades and improvements to the Fermilab accelerator complex aimed at supporting a world-leading neutrino program over the next several decades. PIP-II is an integral part of the strategic plan for U.S. High Energy Physics as described in the Particle Physics Project Prioritization Panel (P5) report of May 2014 and formalized through the Mission Need Statement approved in November 2015. As an immediate goal, PIP-II is focused on upgrades to the Fermilab accelerator complex capable of providing proton beam power in excess of 1 MW on target at the initiation of themore » Long Baseline Neutrino Facility/Deep Underground Neutrino Experiment (LBNF/DUNE) program, currently anticipated for the mid- 2020s. PIP-II is a part of a longer-term goal of establishing a high-intensity proton facility that is unique within the world, ultimately leading to multi-MW capabilities at Fermilab....« less

Cave Buttes Dam Master Plan, Phoenix, Arizona and Vicinity (Including New River).

DTIC Science & Technology

1982-03-01

Mar. 1975 Arizona, Hydrology, Part 1 3 New River and Phoenix City Streams, Mar. 1976 July 1977 Arizona, Design Memorandum No. 3, (SPD App) General ...with Maricopa County, Arizona CEQ) 3 New River and Phoenix City Streams, Arizona, Design Memorandum No. 3, General Design Memorandum--Phase II, Project...Hydrology Part 2 3 New River and Phoenix City Streams, Arizona, Design Memorandum No. 3, General Design Memorandum--Phase II, Project Design Part 3

Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Receptor Antagonist

PubMed Central

Khan, Nemat; Muralidharan, Arjun; Smith, Maree T.

2017-01-01

Recent preclinical and proof-of-concept clinical studies have shown promising analgesic efficacy of selective small molecule angiotensin II type 2 (AT2) receptor antagonists in the alleviation of peripheral neuropathic pain. However, their cellular and molecular mechanism of action requires further investigation. To address this issue, groups of adult male Sprague–Dawley rats with fully developed unilateral hindpaw hypersensitivity, following chronic constriction injury (CCI) of the sciatic nerve, received a single intraperitoneal bolus dose of the small molecule AT2 receptor antagonist, EMA300 (10 mg kg-1), or vehicle. At the time of peak EMA300-mediated analgesia (∼1 h post-dosing), groups of CCI-rats administered either EMA300 or vehicle were euthanized. A separate group of rats that underwent sham surgery were also included. The lumbar (L4–L6) dorsal root ganglia (DRGs) were obtained from all experimental cohorts and processed for immunohistochemistry and western blot studies. In vehicle treated CCI-rats, there was a significant increase in the expression levels of angiotensin II (Ang II), but not the AT2 receptor, in the ipsilateral lumbar DRGs. The elevated levels of Ang II in the ipsilateral lumbar DRGs of CCI-rats were at least in part contributed by CD3+ T-cells, satellite glial cells (SGCs) and subsets of neurons. Our findings suggest that the analgesic effect of EMA300 in CCI-rats involves multimodal actions that appear to be mediated at least in part by a significant reduction in the otherwise increased expression levels of Ang II as well as the number of Ang II-expressing CD3+ T-cells in the ipsilateral lumbar DRGs of CCI-rats. Additionally, the acute anti-allodynic effects of EMA300 in CCI-rats were accompanied by rescue of the otherwise decreased expression of mature nerve growth factor (NGF) in the ipsilateral lumbar DRGs of CCI-rats. In contrast, the increased expression levels of TrkA and glial fibrillary acidic protein in the ipsilateral lumbar DRGs of vehicle-treated CCI-rats were not attenuated by a single bolus dose of EMA300. Consistent with our previous findings, there was also a significant decrease in the augmented levels of the downstream mediators of Ang II/AT2 receptor signaling, i.e., phosphorylated-p38 mitogen-activated protein kinase (MAPK) and phosphorylated-p44/p42 MAPK, in the ipsilateral lumbar DRGs. PMID:29200998

Recent Developments in Gravity-Wave Effects in Climate Models and the Global Distribution of Gravity-Wave Momentum Flux from Observations and Models

DTIC Science & Technology

2010-07-01

by changes in wind and stability to a vertical wavelength lying outside the observable range. Gravity-wave parametrizations also represent intermit ...tropopause variability. J. Atmos. Sci. 65: 1817–1837. Salby ML. 1982. Sampling theory for asynoptic satellite observations. Part II: Fast Fourier synoptic

Attentional Preference and Experience: II. An Exploratory Longitudinal Study of the Effects of Visual Familiarity and Responsiveness.

ERIC Educational Resources Information Center

Uzgiris, Ina C.; Hunt, J. McV.

The human infant is now considered capable of active informational interaction with the environment. This study tested certain hypotheses concerning the nature of that interaction. These hypotheses, developed partly from Piaget's work, are (1) that repeated visual encounters with a stimulus pattern leads first to attentional preference for that…

Why is Organizing Human Resource Development so Problematic? Perspectives from the Learning-Network Theory (Part II)

ERIC Educational Resources Information Center

Poell, Rob F.; Van Der Krogt, Ferd

2017-01-01

Purpose: Human resource development (HRD) is an important field within management. Developing employees is often regarded as an instrument to improve the internal labor market and support organizational change. Organizing HRD to these ends, however, is frequently a problematic affair, in terms of training effectiveness, participant motivation and…

An Evaluation of Results and Effectiveness of Job Banks: Volume I, Parts I and II.

ERIC Educational Resources Information Center

Ultrasystems, Inc., Irvine, CA.

In order to assist the Manpower Administration of the U. S. Department of Labor in the planning, development, and expansion of over a hundred computerized "job banks," located in nearly every State, field interviews were conducted with job applicants, employers, Employment Service staff, and community agencies to evaluate the current…

77 FR 43905 - Endangered and Threatened Wildlife and Plants; Endangered Status for the Diamond Darter and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... (9 mi) of Blue Creek was affected by the fish kill (McCoy 2010, p. 1). The effects of the fish kill... Vol. 77 Thursday, No. 144 July 26, 2012 Part II Department of the Interior Fish and Wildlife... / Thursday, July 26, 2012 / Proposed Rules#0;#0; [[Page 43906

75 FR 47269 - Pilot Program for Waiver of Patent Owner's Statement in Ex Parte Reexamination Proceedings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-05

... expected to form a portion of the data used in the decision making processes in phases II and III. Dated... likely to improve efficiency. Such changes may include internal procedural changes, rule making that... notice will take effect on August 5, 2010. FOR FURTHER INFORMATION CONTACT: Robert A. Clarke, Kenneth M...

12 CFR 571.27 - Renewal of opt-out.

Code of Federal Regulations, 2010 CFR

2010-01-01

... period. Each opt-out renewal must be effective for a period of at least five years as provided in § 571... (ii) As part of a joint renewal notice from two or more members of an affiliated group of companies... provided by multiple companies with the ABC name or multiple companies in the ABC group or family of...

As the World Turns: The Shifting Developmental Issues Facing Today's College Man, Part II.

ERIC Educational Resources Information Center

Franklin, E. Bernard

1997-01-01

Discusses issues facing black male college students, and ways colleges and universities can support their growth more effectively. Identifies and explores students' unmet needs: to feel loved, feel accepted, feel competent, have power, resolve pain and anger from lack of appropriate male guidance, find meaning and purpose in life's struggles, and…

JPRS Report, East Europe

DTIC Science & Technology

1987-11-24

of the assortment of manufactured parts for partial and complete frames, as well as abutments , support walls, and bridgehead construction...Uniform Series II Generation based on anticipated spans; and • Increased effectiveness of prefabrication for steel and masonry bridge construction...support structures and abutments . Parallel to and on an equal par with standard primary construction trades already cited, the scientific-technical

Building Effective Partnerships: A Win-Win Approach. Module II. Job Match: Together for Good Business.

ERIC Educational Resources Information Center

Banzhaf, Katie; And Others

Intended for use with personnel in business, industry, and human service agencies, the training module is part of a kit designed to demonstrate how individuals with disabilities and older persons can be assimilated successfully into the labor force. This module explains partnerships between businesses and human service agencies. It emphasizes the…

25 CFR 547.3 - What are the definitions for this part?

Code of Federal Regulations, 2011 CFR

2011-04-01

... TECHNICAL STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.3 What are the... Commission. Class II game. The same as “class II gaming” in 25 U.S.C. 2703(7)(A). Class II gaming system. All..., that function together to aid the play of one or more Class II games, including accounting functions...

25 CFR 547.3 - What are the definitions for this part?

Code of Federal Regulations, 2012 CFR

2012-04-01

... TECHNICAL STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.3 What are the... Commission. Class II game. The same as “class II gaming” in 25 U.S.C. 2703(7)(A). Class II gaming system. All..., that function together to aid the play of one or more Class II games, including accounting functions...

25 CFR 547.3 - What are the definitions for this part?

Code of Federal Regulations, 2010 CFR

2010-04-01

... TECHNICAL STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.3 What are the... Commission. Class II game. The same as “class II gaming” in 25 U.S.C. 2703(7)(A). Class II gaming system. All..., that function together to aid the play of one or more Class II games, including accounting functions...

The effect of resveratrol on angiotensin II levels and the rate of transcription of its receptors in the rat cardiac hypertrophy model.

PubMed

Dorri Mashhadi, Fahimeh; Zavvar Reza, Javad; Jamhiri, Mohabbat; Hafizi, Zeinab; Zare Mehrjardi, Fatemeh; Safari, Fatemeh

2017-03-01

This study investigated the effect of resveratrol on serum and cardiac levels of angiotensin II and transcription of its main receptors following pressure overload induced-hypertrophy. Rats were divided into untreated (Hyp) and resveratrol treated hypertrophied groups (H + R). Intact animals served as the control (Ctl). Cardiac hypertrophy was induced by abdominal aortic banding. Blood pressure (BP) was recorded via left carotid artery cannula. Fibrosis was confirmed by Masson trichrome staining. Angiotensin II level was measured using an ELIZA test. Gene expression was assessed by a real time PCR (RT-PCR) technique. We observed that in the H + R group BP and heart weight/body weight were decreased significantly (p < 0.001, p < 0.05, respectively vs Hyp). The cardiac levels of angiotensin II and AT1a mRNA were increased in the Hyp group (p < 0.01 vs Ctl). In the H + R group the AT1a mRNA level was decreased significantly (p < 0.05 vs Hyp). It could be concluded that resveratrol protects the heart against hypertrophy progression in part by affecting cardiac AT1a transcription.

[The influence of C-taurine antioxidant complex on biochemical blood parameters in the process of treatment of patients with diabetes mellitus of type II with nonproliferative diabetic retinopathy].

PubMed

Lekishvili, S E

2014-02-01

The purpose of this investigation is to study the effect of C- taurine complex of antioxidants on blood biochemical parameters in the process of treatment of patients with diabetes mellitus of type II with NPDR. 68 patients (136 eyes) were enrolled in the study. The monitoring of the patient lasted for 3 months. The character of changes of the basic visual functions has been examined. The patients were divided into 2 groups (main and control). Treatment of patients with main group conducted antioxidant complex Taurine + Vitamin C for 42 days. namely. Thus, we have revealed antioxidant activity of the combination of taurine and vitamin C with positive effect on the indexes of carbohydrate, lipid metabolism and hepatoprotective characteristics in patients with diabetes mellitus type II with NPDR. Taking into consideration the peculiarities of correlation relationships between functional, clinical and biochemical parameters and the results of experimental studies on animal it is acceptable to use Taurine complex + Vitamin C as part of conservative treatment of patients with diabetes mellitus type II with NPDR.

A tensor analysis to evaluate the effect of high-pull headgear on Class II malocclusions.

PubMed

Ngan, P; Scheick, J; Florman, M

1993-03-01

The inaccuracies inherent in cephalometric analysis of treatment effects are well known. The objective of this article is to present a more reliable research tool in the analysis of cephalometric data. Bookstein introduced a dilation function by means of a homogeneous deformation tensor as a method of describing changes in cephalometric data. His article gave an analytic description of the deformation tensor that permits the rapid and highly accurate calculation of it on a desktop computer. The first part of this article describes the underlying ideas and mathematics. The second part uses the tensor analysis to analyze the cephalometric results of a group of patients treated with high-pull activator (HPA) to demonstrate the application of this research tool. Eight patients with Class II skeletal open bite malocclusions in the mixed dentition were treated with HPA. A control sample consisting of eight untreated children with Class II who were obtained from The Ohio State University Growth Study was used as a comparison group. Lateral cephalograms taken before and at the completion of treatment were traced, digitized, and analyzed with the conventional method and tensor analysis. The results showed that HPA had little or no effect on maxillary skeletal structures. However, reduction in growth rate was found with the skeletal triangle S-N-A, indicating a posterior tipping and torquing of the maxillary incisors. The treatment also induced additional deformation on the mandible in a downward and slightly forward direction. Together with the results from the conventional cephalometric analysis, HPA seemed to provide the vertical and rotational control of the maxilla during orthopedic Class II treatment by inhibiting the downward and forward eruptive path of the upper posterior teeth. The newly designed computer software permits rapid analysis of cephalometric data with the tensor analysis on a desktop computer. This tool may be useful in analyzing growth changes for research data.

Roles of p62 in BDNF-dependent autophagy suppression and neuroprotection against mitochondrial dysfunction in rat cortical neurons.

PubMed

Wu, Chia-Lin; Chen, Chien-Hui; Hwang, Chi-Shin; Chen, Shang-Der; Hwang, Wei-Chao; Yang, Ding-I

2017-03-01

Previously, we have reported that pre-conditioning of primary rat cortical neurons with brain-derived neurotrophic factor (BDNF) may exert neuroprotective effects against 3-nitropropionic acid (3-NP), a mitochondrial complex II inhibitor. However, the underlying mechanisms, especially potential involvements of autophagy, remain elusive. In this work, we tested the hypothesis that BDNF may suppress 3-NP-induced autophagy to exert its neuroprotective effects by inducing the expression of p62/sequestosome-1 in primary cortical neurons. We found that 3-NP increased total level of microtubule-associated protein 1A/1B-light chain (LC)-3 as well as the LC3-II/LC3-I ratio, an index of autophagy, in primary cortical neurons. BDNF decreased LC3-II/LC3-I ratio and time-dependently induced expression of p62. Knockdown of p62 by siRNA restored LC3-II/LC3-I ratio and increased total LC3 levels associated with BDNF exposure; p62 knockdown also abolished BDNF-dependent neuroprotection against 3-NP. Upstream of p62, we found that BDNF triggered phosphorylation of mammalian target of rapamycin (mTOR) and its downstream mediator p70S6K; importantly, the mTOR inhibitor rapamycin reduced both BDNF-dependent p62 induction as well as 3-NP resistance. BDNF is known to induce c-Jun in cortical neurons. We found that c-Jun knockdown in part attenuated BDNF-mediated p62 induction, whereas p62 knockdown had no significant effects on c-Jun expression. In addition to suppressing p62 induction, rapamycin also partially suppressed BDNF-induced c-Jun expression, but c-Jun knockdown failed to affect mTOR activation. Together, our results suggested that BDNF inhibits 3-NP-induced autophagy via, at least in part, mTOR/c-Jun-dependent induction of p62 expression, together contributing to neuroprotection against mitochondrial inhibition. © 2016 International Society for Neurochemistry.

A novel model of magnetorheological damper with hysteresis division

NASA Astrophysics Data System (ADS)

Yu, Jianqiang; Dong, Xiaomin; Zhang, Zonglun

2017-10-01

Due to the complex nonlinearity of magnetorheological (MR) behavior, the modeling of MR dampers is a challenge. A simple and effective model of MR damper remains a work in progress. A novel model of MR damper is proposed with force-velocity hysteresis division method in this study. A typical hysteresis loop of MR damper can be simply divided into two novel curves with the division idea. One is the backbone curve and the other is the branch curve. The exponential-family functions which capturing the characteristics of the two curves can simplify the model and improve the identification efficiency. To illustrate and validate the novel phenomenological model with hysteresis division idea, a dual-end MR damper is designed and tested. Based on the experimental data, the characteristics of the novel curves are investigated. To simplify the parameters identification and obtain the reversibility, the maximum force part, the non-dimensional backbone part and the non-dimensional branch part are derived from the two curves. The maximum force part and the non-dimensional part are in multiplication type add-rule. The maximum force part is dependent on the current and maximum velocity. The non-dominated sorting genetic algorithm II (NSGA II) based on the design of experiments (DOE) is employed to identify the parameters of the normalized shape functions. Comparative analysis is conducted based on the identification results. The analysis shows that the novel model with few identification parameters has higher accuracy and better predictive ability.

Hemodynamic actions and mechanisms of systemically administered α-MSH analogs in mice.

PubMed

Rinne, Petteri; Tikka, Sanna; Mäkelä, Satu; Streng, Tomi; Savontaus, Eriika

2012-11-01

α-Melanocyte-stimulating hormone (α-MSH) regulates important physiological functions including energy homeostasis and inflammation. Potent analogs of α-MSH, [Nle(4), D-Phe(7)]-α-MSH (NDP-α-MSH) and melanotan-II (MT-II), are widely used in pharmacological studies, but the hemodynamic effects associated with their systemic administration have not been thoroughly examined. Therefore, we investigated the hemodynamic actions of these compounds in anesthetized and conscious C57Bl/6N mice using peripheral routes of administration. NDP-α-MSH and MT-II induced mild changes in blood pressure and heart rate in anesthetized mice compared to the effects observed in conscious mice, suggesting that anesthesia distorts the hemodynamic actions of α-MSH analogs. In conscious mice, NDP-α-MSH and MT-II increased blood pressure and heart rate in a dose-dependent manner, but the tachycardic effect was more prominent than the pressor effect. Pretreatment with the melanocortin (MC) 3/4 receptor antagonist SHU9119 abolished these hemodynamic effects. Furthermore, the blockade of β(1)-adrenoceptors with metoprolol prevented the pressor effect and partly the tachycardic action of α-MSH analogs, while the ganglionic blocker hexamethonium abrogated completely the difference in heart rate between vehicle and α-MSH treatments. These findings suggest that the pressor effect is primarily caused by augmentation of cardiac sympathetic activity, but the tachycardic effect seems to involve withdrawal of vagal tone in addition to sympathetic activation. In conclusion, the present results indicate that systemic administration of α-MSH analogs elevates blood pressure and heart rate via activation of MC(3/4) receptor pathways. These effects and the consequent increase in cardiac workload should be taken into account when using α-MSH analogs via peripheral routes of administration. Copyright © 2012 Elsevier Inc. All rights reserved.

Antigenicity of mesenchymal stem cells in an inflamed joint environment.

PubMed

Hill, Jacqueline A; Cassano, Jennifer M; Goodale, Margaret B; Fortier, Lisa A

2017-07-01

OBJECTIVE To determine whether major histocompatability complex (MHC) class II expression in equine mesenchymal stem cells (MSCs) changes with exposure to a proinflammatory environment reflective of an inflamed joint. SAMPLE Cryopreserved bone marrow-derived MSCs from 12 horses and cartilage and synovium samples from 1 horse euthanized for reasons other than lameness. PROCEDURES In part 1 of a 3-part study, the suitability of a quantitative reverse transcriptase PCR (qRT-PCR) assay for measurement of MHC class II expression in MSCs following stimulation with interferon (IFN)-γ was assessed. In part 2, synoviocyte-cartilage cocultures were or were not stimulated with interleukin (IL)-1β (10 ng/mL) to generate conditioned media that did and did not (control) mimic an inflamed joint environment. In part 3, a qRT-PCR assay was used to measure MSC MHC class II expression after 96 hours of incubation with 1 of 6 treatments (control-conditioned medium, IL-1β-conditioned medium, and MSC medium alone [untreated control] or with IL-1β [10 ng/mL], tumor necrosis factor-α [10 ng/mL], or IFN-γ [100 ng/mL]). RESULTS The qRT-PCR assay accurately measured MHC class II expression. Compared with MHC class II expression for MSCs exposed to the untreated control medium, that for MSCs exposed to IL-1β was decreased, whereas that for MSCs exposed to IFN-γ was increased. Neither the control-conditioned nor tumor necrosis factor-α medium altered MHC class II expression. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that MSC exposure to proinflammatory cytokine IL-1β decreased MHC class II expression and antigenicity. Treatment of inflamed joints with allogeneic MSCs might not be contraindicated, but further investigation is warranted.

40 CFR 63.163 - Standards: Pumps in light liquid service.

Code of Federal Regulations, 2013 CFR

2013-07-01

... later than 1 year after the compliance date; and (C) Phase III, beginning no later than 21/2 years after... requirements; and (B) Beginning no later than 1 year after initial start-up, comply with the Phase III... parts per million or greater. (ii) For Phase II, an instrument reading of 5,000 parts per million or...

40 CFR 63.163 - Standards: Pumps in light liquid service.

Code of Federal Regulations, 2012 CFR

2012-07-01

... later than 1 year after the compliance date; and (C) Phase III, beginning no later than 21/2 years after... requirements; and (B) Beginning no later than 1 year after initial start-up, comply with the Phase III... parts per million or greater. (ii) For Phase II, an instrument reading of 5,000 parts per million or...

40 CFR 63.163 - Standards: Pumps in light liquid service.

Code of Federal Regulations, 2014 CFR

2014-07-01

... later than 1 year after the compliance date; and (C) Phase III, beginning no later than 21/2 years after... requirements; and (B) Beginning no later than 1 year after initial start-up, comply with the Phase III... parts per million or greater. (ii) For Phase II, an instrument reading of 5,000 parts per million or...

Biology--Chemistry--Physics, Students' Guide, A Three-Year Sequence, Parts I and II.

ERIC Educational Resources Information Center

Scott, Arthur; And Others

Parts I and II of the students' guide to the three-year integrated biology, chemistry, and physics course being prepared by the Portland Project Committee are contained in this guide. A committee reviewed and selected material developed by the national course improvement groups--Physical Science Study Committee, Chemical Bond Approach, Chemical…

A Survey of Telecommunications Technology. Part II. President's Task Force on Communications Policy. Staff Paper One, Part II.

ERIC Educational Resources Information Center

Rostow, Eugene V.

The document contains the final four appendices to a staff paper submitted to the President's Task Force on Communications Policy. "The Digital Loop" describes changes in urban telecommunications which are predicted for 1970-80, considering three possible systems: paired wires with single analog signals (present telephones), coaxial…

42 CFR 498.3 - Scope and applicability.

Code of Federal Regulations, 2012 CFR

2012-10-01

... PROGRAM AND FOR DETERMINATIONS THAT AFFECT THE PARTICIPATION OF ICFs/IID AND CERTAIN NFs IN THE MEDICAID..., subpart D—for nursing facilities (NFs). (ii) Part 488, subpart E (§ 488.330(e))—for SNFs and NFs. (ii) Part 488, subpart E (§ 488.330(e)) and subpart F (§ 488.446)—for SNFs and NFs and their administrators...

42 CFR 498.3 - Scope and applicability.

Code of Federal Regulations, 2011 CFR

2011-10-01

... PROGRAM AND FOR DETERMINATIONS THAT AFFECT THE PARTICIPATION OF ICFs/MR AND CERTAIN NFs IN THE MEDICAID..., subpart D—for nursing facilities (NFs). (ii) Part 488, subpart E (§ 488.330(e))—for SNFs and NFs. (ii) Part 488, subpart E (§ 488.330(e)) and subpart F (§ 488.446)—for SNFs and NFs and their administrators...

An Interview with Ira Shor--Part II.

ERIC Educational Resources Information Center

Tinberg, Howard

1999-01-01

Presents Part II of an interview with Ira Shor reflecting on the state of community colleges since the 1960s. Discusses how the most important thing to teach is critical inquiry and critical literacy, to study something in a methodical way and to communicate knowledge gained with articulate depth to a real audience. Outlines 13 goals for schooling…

Implementation of Head Start Planned Variation: 1970-1971. Part II.

ERIC Educational Resources Information Center

Lukas, Carol Van Deusen; Wohlleb, Cynthia

This volume of appendices is Part II of a study of program implementation in 12 models of Head Start Planned Variation. It presents details of the data analysis, copies of data collection instruments, and additional analyses and statistics. The appendices are: (A) Analysis of Variance Designs, (B) Copies of Instruments, (C) Additional Analyses,…

75 FR 75624 - Cost of Living Adjustment to Satellite Carrier Compulsory License Royalty Rates

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-06

... ROYALTY FEES FOR SECONDARY TRANSMISSIONS BY SATELLITE CARRIERS 0 1. The authority citation for part 386... revising paragraphs (b)(1)(ii) and (b)(2)(ii) as follows: Sec. 386.2 Royalty fee for secondary transmission... LIBRARY OF CONGRESS Copyright Royalty Board 37 CFR Part 386 [Docket No. 2010-10 CRB Satellite COLA...

Counselor's Handbook: I, Counselor's Interviewing Guides in Individual Appraisal; II, Counselee Appraisal Patterns Related to Fields of Work.

ERIC Educational Resources Information Center

Bureau of Employment Security (DOL), Washington, DC.

Part I includes guides for appraising individual characteristics such as interests, temperament, educational development, and aptitudes, to help the counselee learn about himself. Part II includes guidelines for appraising individual characteristics as they relate to the 18 fields of work (occupational clusters) which help the counselee learn…

40 CFR Appendix II to Part 1039 - Steady-State Duty Cycles

Code of Federal Regulations, 2011 CFR

2011-07-01

... Appendix II to Part 1039—Steady-State Duty Cycles (a) The following duty cycles apply for constant-speed engines: (1) The following duty cycle applies for discrete-mode testing: D2 mode number Engine speed...(seconds) Engine speed Torque(percent) 1, 2 1a Steady-state 53 Engine governed 100. 1b Transition 20 Engine...

Influence of work clothing on physiological responses and performance during treadmill exercise and the Wildland Firefighter Pack Test.

PubMed

Phillips, Devin B; Ehnes, Cameron M; Welch, Bradley G; Lee, Lauren N; Simin, Irina; Petersen, Stewart R

2018-04-01

This study investigated physiological responses and performance during three separate exercise challenges (Parts I, II, and III) with wildland firefighting work clothing ensemble (boots and coveralls) and a 20.4 kg backpack in four conditions: U-EX (no pack, exercise clothing); L-EX (pack, exercise clothing); U-W (no pack, work clothing); and, L-W (pack and work clothing). Part I consisted of randomly-ordered graded exercise tests, on separate days, in U-EX, L-EX and L-W conditions. Part II consisted of randomly-ordered bouts of sub-maximal treadmill exercise in the four conditions. In Part III, subjects completed, in random-order on separate days, 4.83 km Pack Tests in L-EX or L-W conditions. In Part I, peak oxygen uptake was reduced (p < .05) in L-W. In Part II, mass-specific oxygen uptake was significantly higher in both work clothing conditions. In Part III, Pack Test time was slower (p < .05) in L-W. These results demonstrate the negative impact of work clothing and load carriage on physiological responses to exercise and performance. Copyright © 2017 Elsevier Ltd. All rights reserved.

45 CFR Appendix A to Part 13 - Appendix A to Part 13

Code of Federal Regulations, 2011 CFR

2011-10-01

...-3(h)(2)(B)(ii); 1395l(q)(2)(B)(i); 1395m(a)(11)(A), (c)(4)(C); 1395w-2(b)(2)(A); 1395w-4(g)(1), (g)(3)(B), (g)(4)(B)(ii); 1395nn(g)(5); 1395ss(a)(2), (p)(8), (p)(9)(C), (q)(5)(C), (r)(6)(A), (s)(3...-7a(c)(2); 1320b-10(c); 1395i-3(b)(3)(B)(ii), (g)(2)(A)(i); 1395l (h)(5)(D), (i)(6); 1395m(a)(11)(A...

Time frequency analysis of olfactory induced EEG-power change.

PubMed

Schriever, Valentin Alexander; Han, Pengfei; Weise, Stefanie; Hösel, Franziska; Pellegrino, Robert; Hummel, Thomas

2017-01-01

The objective of the present study was to investigate the usefulness of time-frequency analysis (TFA) of olfactory-induced EEG change with a low-cost, portable olfactometer in the clinical investigation of smell function. A total of 78 volunteers participated. The study was composed of three parts where olfactory stimuli were presented using a custom-built olfactometer. Part I was designed to optimize the stimulus as well as the recording conditions. In part II EEG-power changes after olfactory/trigeminal stimulation were compared between healthy participants and patients with olfactory impairment. In Part III the test-retest reliability of the method was evaluated in healthy subjects. Part I indicated that the most effective paradigm for stimulus presentation was cued stimulus, with an interstimulus interval of 18-20s at a stimulus duration of 1000ms with each stimulus quality presented 60 times in blocks of 20 stimuli each. In Part II we found that central processing of olfactory stimuli analyzed by TFA differed significantly between healthy controls and patients even when controlling for age. It was possible to reliably distinguish patients with olfactory impairment from healthy individuals at a high degree of accuracy (healthy controls vs anosmic patients: sensitivity 75%; specificity 89%). In addition we could show a good test-retest reliability of TFA of chemosensory induced EEG-power changes in Part III. Central processing of olfactory stimuli analyzed by TFA reliably distinguishes patients with olfactory impairment from healthy individuals at a high degree of accuracy. Importantly this can be achieved with a simple olfactometer.

Globalization in the pharmaceutical industry, Part II.

PubMed

Casadio Tarabusi, C; Vickery, G

1998-01-01

This is the second of a two-part report on the pharmaceutical industry. Part II begins with a discussion of foreign direct investment and inter-firm networks, which covers international mergers, acquisitions, and minority participation; market shares of foreign-controlled firms; international collaboration agreements (with a special note on agreements in biotechnology); and licensing agreements. The final section of the report covers governmental policies on health and safety regulation, price regulation, industry and technology, trade, foreign investment, protection of intellectual property, and competition.

Guidance, Navigation and Control Digital Emulation Technology Laboratory. Volume 1. Part 2. Task 1: Digital Emulation Technology Laboratory

DTIC Science & Technology

1991-09-27

AD-A241 692 II I] II I11 ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATOIRY REPORT NO. AR-0142-91-001 September 27, 1991... DIGITAL EMULATION TECHNOLOGY LABORATORY Contract No. DASG60-89-C-0142 Sponsored By The United States Army ? trategic Defense Command COMPUTER...ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATORY September 27, 1991 Authors Thomas R. Collins and Stephen R. Wachtel

Northeast Artificial Intelligence Consortium Annual Report 1987. Volume 2, Part B. Discussing, Using, and Recognizing Plans

DTIC Science & Technology

1989-03-01

1978. Williams. B.C. Qualitative Analysis of MOS Circuits. Artificial Inteligence . 1984. 24.. Wilson. K. From Association to Structure. Amsterdam:North...D-A208 378 RADC-TR-88-324, Vol II (of nine), Part B Interim Report March 1969 4. NORTHEAST ARTIFICIAL INTELLIGENCE CONSORTIUM ANNUAL REPORT 1987...II (of nine), Part B 6a. NAME OF PERFORMING ORGANIZATION 6b. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION Northeast Artificial (ff ’aolicbl

Data Analysis Techniques for Physical Scientists

NASA Astrophysics Data System (ADS)

Pruneau, Claude A.

2017-10-01

Preface; How to read this book; 1. The scientific method; Part I. Foundation in Probability and Statistics: 2. Probability; 3. Probability models; 4. Classical inference I: estimators; 5. Classical inference II: optimization; 6. Classical inference III: confidence intervals and statistical tests; 7. Bayesian inference; Part II. Measurement Techniques: 8. Basic measurements; 9. Event reconstruction; 10. Correlation functions; 11. The multiple facets of correlation functions; 12. Data correction methods; Part III. Simulation Techniques: 13. Monte Carlo methods; 14. Collision and detector modeling; List of references; Index.

Pharmacokinetic interaction of fimasartan, a new angiotensin II receptor antagonist, with amlodipine in healthy volunteers.

PubMed

Yi, SoJeong; Kim, Tae-Eun; Yoon, Seo Hyun; Cho, Joo-Youn; Shin, Sang-Goo; Jang, In-Jin; Yu, Kyung-Sang

2011-06-01

Fimasartan (BR-A-657) is a new angiotensin II receptor antagonist used as antihypertensive agent. The objective of this study was to investigate the effect of the coadministration of fimasartan and amlodipine on the steady-state pharmacokinetics of each drug. This study comprised 2 separate parts, A and B; each was a multiple-dose, open-label, 2-period crossover study in healthy male volunteers. In part A, 20 subjects were administered 120 mg of fimasartan alone in period I and fimasartan with 10 mg of amlodipine in period II. In part B, 14 subjects were administered amlodipine alone, followed by coadministration with fimasartan. Blood samples for pharmacokinetics were collected up to 24 hours after the last dosing. The pharmacokinetics of the coadministration of fimasartan and amlodipine were compared with that of each drug alone. The geometric mean ratio and 90% confidence intervals for C(max,ss) and area under the plasma concentration-time curve (AUC)(τ,ss) of fimasartan (with/without amlodipine) were 1.096 (0.746-1.610) and 1.163 (1.001-1.351), respectively. The geometric mean ratios (90% confidence interval) for C(max,ss) and AUC(τ,ss) of amlodipine (with/without fimasartan) after coadministration with fimasartan were 1.037 (0.969-1.110) and 0.975 (0.920-1.033), respectively. Coadministration of fimasartan and amlodipine did not result in clinically relevant changes in the systemic exposure of fimasartan or amlodipine.

Cancer Chemotherapy: Past, Present, and Future—Part I

PubMed Central

Wright, Jane C.

1984-01-01

Cancer is of major concern today because of its high mortality. It is estimated that 66 million people in this country will eventually develop cancer; 1983 estimates were 855,000 new cases and 440,000 deaths from cancer. Because of limitations of surgery and radiation therapy in effecting a cure for cancer, chemotherapy has become increasingly important. The developments in the chemical control of cancer in man are encouraging. This two-part paper covers the historical milestones in the development of the chemical and hormonal control of cancer, present successes with the use of polychemotherapy, and the hopeful trends in research. Part II will be published in a future issue of this journal. PMID:6381742

A randomized, multicenter, phase II/III study to determine the optimal dose and to evaluate the efficacy and safety of pegteograstim (GCPGC) on chemotherapy-induced neutropenia compared to pegfilgrastim in breast cancer patients: KCSG PC10-09.

PubMed

Lee, Ki Hyeong; Kim, Ji-Yeon; Lee, Moon Hee; Han, Hye Sook; Lim, Joo Han; Park, Keon Uk; Park, In Hae; Cho, Eun Kyung; Yoon, So Young; Kim, Jee Hyun; Choi, In Sil; Park, Jae Hoo; Choi, Young Jin; Kim, Hee-Jun; Jung, Kyung Hae; Kim, Si-Young; Oh, Do-Youn; Im, Seock-Ah

2016-04-01

Pegylated granulocyte-colony-stimulating factor (G-CSF) is frequently used to prevent febrile neutropenia (FN) in patients undergoing chemotherapy with a high risk of myelosuppression. This phase II/III study was conducted to determine the adequate dose of pegteograstim, a new formulation of pegylated G-CSF, and to evaluate the efficacy and safety of pegteograstim compared to pegfilgrastim. In the phase II part, 60 breast cancer patients who were undergoing DA (docetaxel and doxorubicin) or TAC (docetaxel, doxorubicin, and cyclophosphamide) chemotherapy were randomly selected to receive a single subcutaneous injection of 3.6 or 6.0 mg pegteograstim on day 2 of each chemotherapy cycle. The phase III part was seamlessly started to compare the dose of pegteograstim at selected in phase II with 6.0 mg pegfilgrastim in 117 breast cancer patients. The primary endpoint of both the phase II and III parts was the duration of grade 4 neutropenia in the chemotherapy cycle 1. The mean duration of grade 4 neutropenia for the 3.6 mg pegteograstim (n = 33) was similar to that for the 6.0 mg pegteograstim (n = 26) (1.97 ± 1.79 days vs. 1.54 ± 0.95 days, p = 0.33). The 6.0 mg pegteograstim was selected to be compared with the 6.0 mg pegfilgrastim in the phase III part. In the phase III part, the primary analysis revealed that the efficacy of pegteograstim (n = 56) was non-inferior to that of pegfilgrastim (n = 59) [duration of grade 4 neutropenia, 1.64 ± 1.18 days vs. 1.80 ± 1.05 days; difference, -0.15 ± 1.11 (p = 0.36, 97.5 % confidence intervals = 0.57 and 0.26)]. The time to the absolute neutrophil count (ANC) recovery of pegteograstim (≥2000/μL) was significantly shorter than that of pegfilgrastim (8.85 ± 1.45 days vs. 9.83 ± 1.20 days, p < 0.0001). Other secondary endpoints showed no significant difference between the two groups. The safety profiles of the two groups did not differ significantly. Pegteograstim was shown to be as effective as pegfilgrastim in the reduction of chemotherapy-induced neutropenia in the breast cancer patients who were undergoing chemotherapy with a high risk of myelosuppression.

Management strategies to effect change in intensive care units: lessons from the world of business. Part II. Quality-improvement strategies.

PubMed

Gershengorn, Hayley B; Kocher, Robert; Factor, Phillip

2014-03-01

The success of quality-improvement projects relies heavily on both project design and the metrics chosen to assess change. In Part II of this three-part American Thoracic Society Seminars series, we begin by describing methods for determining which data to collect, tools for data presentation, and strategies for data dissemination. As Avedis Donabedian detailed a half century ago, defining metrics in healthcare can be challenging; algorithmic determination of the best type of metric (outcome, process, or structure) can help intensive care unit (ICU) managers begin this process. Choosing appropriate graphical data displays (e.g., run charts) can prompt discussions about and promote quality improvement. Similarly, dashboards/scorecards are useful in presenting performance improvement data either publicly or privately in a visually appealing manner. To have compelling data to show, ICU managers must plan quality-improvement projects well. The second portion of this review details four quality-improvement tools-checklists, Six Sigma methodology, lean thinking, and Kaizen. Checklists have become commonplace in many ICUs to improve care quality; thinking about how to maximize their effectiveness is now of prime importance. Six Sigma methodology, lean thinking, and Kaizen are techniques that use multidisciplinary teams to organize thinking about process improvement, formalize change strategies, actualize initiatives, and measure progress. None originated within healthcare, but each has been used in the hospital environment with success. To conclude this part of the series, we demonstrate how to use these tools through an example of improving the timely administration of antibiotics to patients with sepsis.

Effects of activated ACM on expression of signal transducers in cerebral cortical neurons of rats.

PubMed

Wang, Xiaojing; Li, Zhengli; Zhu, Changgeng; Li, Zhongyu

2007-06-01

To explore the roles of astrocytes in the epileptogenesis, astrocytes and neurons were isolated, purified and cultured in vitro from cerebral cortex of rats. The astrocytes were activated by ciliary neurotrophic factor (CNTF) and astrocytic conditioned medium (ACM) was collected to treat neurons for 4, 8 and 12 h. By using Western blot, the expression of calmodulin dependent protein kinase II (CaMK II), inducible nitric oxide synthase (iNOS) and adenylate cyclase (AC) was detected in neurons. The results showed that the expression of CaMK II, iNOS and AC was increased significantly in the neurons treated with ACM from 4 h to 12 h (P<0.05), and that of iNOS and AC peaked at 8 h and 12 h respectively. It was suggested that there might be some epileptogenic factors in the ACM and such signal pathways as NOS-NO-cGMP, Ca2+/CaM-CaMK II and AC-cAMP-PKA might take part in the signal transduction of epileptogenesis.

EFFECT OF AT1 RECEPTOR BLOCKADE ON INTERMITTENT HYPOXIA-INDUCED ENDOTHELIAL DYSFUNCTION

PubMed Central

Marcus, Noah J.; Philippi, Nathan R.; Bird, Cynthia E.; Li, Yu-Long; Schultz, Harold D.; Morgan, Barbara J.

2012-01-01

Chronic intermittent hypoxia (CIH) raises arterial pressure, impairs vasodilator responsiveness, and increases circulating angiotensin II (Ang II); however, the role of Ang II in CIH-induced vascular dysfunction is unknown. Rats were exposed to CIH or room air (NORM), and a subset of these animals was treated with losartan (Los) during the exposure period. After 28 days, vasodilatory responses to acetylcholine or nitroprusside were measured in isolated gracilis arteries. Superoxide levels and Ang II receptor protein expression were measured in saphenous arteries. After 28 days, arterial pressure was increased and acetylcholine-induced vasodilation was blunted in CIH vs. NORM, and this was prevented by Los. Responses to nitroprusside and superoxide levels did not differ between CIH and NORM. Expression of AT2R was decreased and the AT1R:AT2R ratio was increased in CIH vs. NORM, but this was unaffected by Los. These results indicate that the blood pressure elevation and endothelial dysfunction associated with CIH is dependent, at least in part, on RAS signaling. PMID:22728949

Recent Economic Perspectives on Political Economy, Part I*

PubMed Central

Dewan, Torun; Shepsle, Kenneth A.

2013-01-01

In recent years some of the best theoretical work on the political economy of political institutions and processes has begun surfacing outside the political science mainstream in high quality economics journals. This two-part paper surveys these contributions from a recent five-year period. In Part I, the focus is on elections, voting and information aggregation, followed by treatments of parties, candidates, and coalitions. In Part II, papers on economic performance and redistribution, constitutional design, and incentives, institutions, and the quality of political elites are discussed. Part II concludes with a discussion of the methodological bases common to economics and political science, the way economists have used political science research, and some new themes and arbitrage opportunities. PMID:23990686

The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part I: A summary of the current state for clinicians.

PubMed

de Leon, Jose

2015-01-01

The literature on inducers in epilepsy and bipolar disorder is seriously contaminated by false negative findings. This is part i of a comprehensive review on antiepileptic drug (AED) inducers using both mechanistic pharmacological and evidence-based medicine to provide practical recommendations to neurologists and psychiatrists concerning how to control for them. Carbamazepine, phenobarbital and phenytoin, are clinically relevant AED inducers; correction factors were calculated for studied induced drugs. These correction factors are rough simplifications for orienting clinicians, since there is great variability in the population regarding inductive effects. As new information is published, the correction factors may need to be modified. Some of the correction factors are so high that the drugs (e.g., bupropion, quetiapine or lurasidone) should not co-prescribed with potent inducers. Clobazam, eslicarbazepine, felbamate, lamotrigine, oxcarbazepine, rufinamide, topiramate, vigabatrin and valproic acid are grouped as mild inducers which may (i)be inducers only in high doses; (ii)frequently combine with inhibitory properties; and (iii)take months to reach maximum effects or de-induction, definitively longer than the potent inducers. Potent inducers, definitively, and mild inducers, possibly, have relevant effects in the endogenous metabolism of (i)sexual hormones, (ii) vitamin D, (iii)thyroid hormones, (iv)lipid metabolism, and (v)folic acid. Copyright © 2014 SEP y SEPB. Published by Elsevier España. All rights reserved.

Desertification in the south Junggar Basin, 2000-2009: Part II. Model development and trend analysis

NASA Astrophysics Data System (ADS)

Jiang, Miao; Lin, Yi

2018-07-01

The substantial objective of desertification monitoring is to derive its development trend, which facilitates pre-making policies to handle its potential influences. Aiming at this extreme goal, previous studies have proposed a large number of remote sensing (RS) based methods to retrieve multifold indicators, as reviewed in Part I. However, most of these indicators individually capable of characterizing a single aspect of land attributes, e.g., albedo quantifying land surface reflectivity, cannot show a full picture of desertification processes; few comprehensive RS-based models have either been published. To fill this gap, this Part II was dedicated to developing a RS information model for comprehensively characterizing the desertification and deriving its trend, based on the indicators retrieved in Part I in the same case of the south Junggar Basin, China in the last decade (2000-2009). The proposed model was designed to have three dominant component modules, i.e., the vegetation-relevant sub-model, the soil-relevant sub-model, and the water-relevant sub-model, which synthesize all of the retrieved indicators to integrally reflect the processes of desertification; based on the model-output indices, the desertification trends were derived using the least absolute deviation fitting algorithm. Tests indicated that the proposed model did work and the study area showed different development tendencies for different desertification levels. Overall, this Part II established a new comprehensive RS information model for desertification risk assessment and its trend deriving, and the whole study comprising Part I and Part II advanced a relatively standard framework for RS-based desertification monitoring.

Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats.

PubMed

Vanourková, Z; Kramer, H J; Husková, Z; Cervenka, L; Vanecková, I

2010-01-01

The relationship between angiotensin II (ANG II) and endothelin-1 (ET-1) is known to be complex; both peptides can initiate and potentiate the gene expression of each other. This pilot study investigated the effects of the AT(1) receptor blocker losartan or the direct renin inhibitor aliskiren on mean arterial pressure (MAP) and albuminuria and the renal ANG II and ET-1 levels. 3-month-old male Ren-2 transgenic rats (TGR) were treated either with losartan (5 mg kg(-1) day(-1)) or aliskiren (10 mg kg(-1) day(-1)) for 10 weeks. At the end of the experiment, rats were decapitated and cortical and papillary parts of kidneys were separated. Plasma and tissue ANG II levels were measured by RIA and tissue ET-1 concentrations by ELISA. In all four groups of animals ET-1 levels were lowest in renal cortex and more than 100-fold higher in the papilla. Cortical and papillary ET-1 concentrations in untreated TGR significantly exceeded those of control HanSD rats and were significantly depressed by both drugs. In both strains, papillary ANG II concentrations were moderately but significantly higher than cortical ANG II, TGR exhibited higher ANG II levels both in cortex and papilla as compared to control HanSD rats. Aliskiren and losartan at the doses used depressed similarly the levels of ANG II in cortex and papilla and reduced ET-1 significantly in the renal cortex and papilla below control levels in HanSD rats. Albuminuria, which was more than twice as high in TGR as in HanSD rats, was normalized with aliskiren and reduced by 28% with losartan, although MAP was reduced to a similar degree by both drugs. Despite similar reductions of MAP and renal ET-1 and ANG II levels aliskiren appears to be more effective than losartan, at the doses used, in reducing albuminuria in heterozygous hypertensive Ren-2 rats.

A Study of the Type II-Plateau Supernova SN 2014cx

NASA Astrophysics Data System (ADS)

Flatland, Kelsi; Leonard, Douglas Christopher; Williams, George Grant; Smith, Paul S.; Bilinski, Christopher; Dessart, Luc; Gonzalez, Luis; Hoffman, Jennifer L.; Huk, Leah; Milne, Peter; Smith, Nathan

2015-08-01

The type II-plateau (II-P) class of supernova is the most commonly observed type of core-collapse event, and yet the basic characteristics of this class are still being defined (e.g. Pejcha & Prieto 2015). Here we add to the growing sample of type II-P events with well-sampled data from observations of SN 2014cx. SN 2014cx was independently discovered on September 2, 2014 UT by Nakano et al. (2014; CBET 3963) and Holoien et al. (2014; ATEL 6436) in the nearby (d ~ 20.7 Mpc, Tully 1988) SBd galaxy NGC 337. It was classified as a young Type II supernova through spectra taken within a day of discovery at both optical (Nakano et al. 2014) and near-infrared (Morrell et al. 2014; ATEL 6442) wavelengths. Later (Andrews et al. 2015; ATEL 7084), it was photometrically determined to be specifically a type II-P supernova, indicating the core-collapse event of a progenitor that had a large hydrogen envelope (Pejcha & Prieto 2015). We initiated a photometric and spectropolarimetric campaign to follow SN 2014cx; over a five month period following the supernova's discovery, we obtained optical images using the 1-meter telescope at Mount Laguna Observatory as part of the MOunt LAguna SUpernova Survey (MOLASUS), and spectra as part of the SuperNova SpectroPOLarimetry project (SNSPOL). Here we present the initial analysis of the photometry and spectroscopy obtained as part of this campaign. We acknowledge support from NSF grants AST-1009571 and AST-1210311, under which part of this research was carried out.

A Study of the Type II-Plateau Supernova SN 2014cx

NASA Astrophysics Data System (ADS)

Flatland, Kelsi; Leonard, Douglas C.; Williams, Grant; Smith, Paul S.; Bilinski, Christopher; Gonzalez, Luis; Hoffman, Jennifer L.; Huk, Leah N.; Milne, Peter; Smith, Nathan; Supernova Spectropolarimetry Project

2016-06-01

The type II-plateau (II-P) class of supernova is the most commonly observed type of core-collapse event, and yet the basic characteristics of this class are still being defined (e.g. Pejcha & Prieto 2015). Here we add to the growing sample of type II-P events with well-sampled data from observations of SN 2014cx. SN 2014cx was independently discovered on September 2, 2014 UT by Nakano et al. (2014; CBET 3963) and Holoien et al. (2014; ATEL 6436) in the nearby (d ~ 20.7 Mpc, Tully 1988) SBd galaxy NGC 337. It was classified as a young Type II supernova through spectra taken within a day of discovery at both optical (Nakano et al. 2014) and near-infrared (Morrell et al. 2014; ATEL 6442) wavelengths. Later (Andrews et al. 2015; ATEL 7084), it was photometrically determined to be specifically a type II-P supernova, indicating the core-collapse event of a progenitor that had a large hydrogen envelope (Pejcha & Prieto 2015). We initiated a photometric and spectropolarimetric campaign to follow SN 2014cx; over a five month period following the supernova's discovery, we obtained optical images using the 1-meter telescope at Mount Laguna Observatory as part of the MOunt LAguna SUpernova Survey (MOLASUS), and spectra as part of the SuperNova SpectroPOLarimetry project (SNSPOL). Here we present the analysis of the photometry and spectroscopy obtained as part of this campaign. We acknowledge support from NSF grants AST-1009571 and AST-1210311, under which part of this research was carried out.

Confirmatory Factor Analysis of the Beck Depression Inventory-II in Bariatric Surgery Candidates

ERIC Educational Resources Information Center

Hall, Brian J.; Hood, Megan M.; Nackers, Lisa M.; Azarbad, Leila; Ivan, Iulia; Corsica, Joyce

2013-01-01

Screening for depression is an integral part of psychological evaluations conducted prior to bariatric surgery. The Beck Depression Inventory-II (BDI-II) is the most commonly used measure of depression in these treatment evaluations. The reliability and validity of the BDI-II has not yet been evaluated within bariatric surgery-seeking samples,…

Title II, Part A: Don't Scrap It, Don't Dilute It, Fix It

ERIC Educational Resources Information Center

Coggshall, Jane G.

2015-01-01

The Issue: Washington is taking a close look at Title II, Part A (Title IIA) of the Elementary and Secondary Education Act (ESEA) as Congress debates reauthorization. The program sends roughly $2.5 billion a year to all states and nearly all districts to "(1) increase student academic achievement through strategies such as improving teacher…

Authority, Rules, and Aggression. A Cross-National Study of Children's Judgments of the Justice of Aggressive Confrontations. Part II. Final Report.

ERIC Educational Resources Information Center

Minturn, Leigh; And Others

This document is Part II of an extensive cross-cultural project which investigated the socialization patterns of children into the compliance systems of society, and focuses upon aggressive behavior and compliant relationships, particularly in the school. Students were selected from comparable grade levels in six countries - Denmark, Greece,…

29 CFR 782.1 - Statutory provisions considered.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 1935, (part II of the Interstate Commerce Act, 49 Stat. 546, as amended; 49 U.S.C. 304, as amended by Pub. L. 89-670, section 8e which substituted “Secretary of Transportation” for “Interstate Commerce... solely by virtue of section 204(a)(3a) of part II of the Interstate Commerce Act. (Pub. L. 939, 84th Cong...

40 CFR Table 4 to Subpart Bbbb of... - Model Rule-Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a

Code of Federal Regulations, 2011 CFR

2011-07-01

... Existing Small Municipal Waste Combustion Unit a 4 Table 4 to Subpart BBBB of Part 60 Protection of... NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Small Municipal Waste Combustion... Part 60—Model Rule—Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a For...

40 CFR Table 4 to Subpart Bbbb of... - Model Rule-Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a

Code of Federal Regulations, 2014 CFR

2014-07-01

... Existing Small Municipal Waste Combustion Unit a 4 Table 4 to Subpart BBBB of Part 60 Protection of... NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Small Municipal Waste Combustion... Part 60—Model Rule—Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a For...

40 CFR Table 4 to Subpart Bbbb of... - Model Rule-Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a

Code of Federal Regulations, 2010 CFR

2010-07-01

... Existing Small Municipal Waste Combustion Unit a 4 Table 4 to Subpart BBBB of Part 60 Protection of... NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Small Municipal Waste Combustion... Part 60—Model Rule—Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a For...

40 CFR Table 4 to Subpart Bbbb of... - Model Rule-Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a

Code of Federal Regulations, 2012 CFR

2012-07-01

... Existing Small Municipal Waste Combustion Unit a 4 Table 4 to Subpart BBBB of Part 60 Protection of... NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Small Municipal Waste Combustion... Part 60—Model Rule—Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a For...

40 CFR Table 4 to Subpart Bbbb of... - Model Rule-Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a

Code of Federal Regulations, 2013 CFR

2013-07-01

... Existing Small Municipal Waste Combustion Unit a 4 Table 4 to Subpart BBBB of Part 60 Protection of... NEW STATIONARY SOURCES Emission Guidelines and Compliance Times for Small Municipal Waste Combustion... Part 60—Model Rule—Class II Emission Limits for Existing Small Municipal Waste Combustion Unit a For...

Effect of Melanotan-II on Brain Fos Immunoreactivity and Oxytocin Neuronal Activity and Secretion in Rats.

PubMed

Paiva, L; Sabatier, N; Leng, G; Ludwig, M

2017-02-01

Melanocortins stimulate the central oxytocin systems that are involved in regulating social behaviours. Alterations in central oxytocin have been linked to neurological disorders such as autism, and melanocortins have been proposed for therapeutic treatment. In the present study, we investigated how systemic administration of melanotan-II (MT-II), a melanocortin agonist, affects oxytocin neuronal activity and secretion in rats. The results obtained show that i.v., but not intranasal, administration of MT-II markedly induced Fos expression in magnocellular neurones of the supraoptic (SON) and paraventricular nuclei (PVN) of the hypothalamus, and this response was attenuated by prior i.c.v. administration of the melanocortin antagonist, SHU-9119. Electrophysiological recordings from identified magnocellular neurones of the SON showed that i.v. administration of MT-II increased the firing rate in oxytocin neurones but did not trigger somatodendritic oxytocin release within the SON as measured by microdialysis. Our data suggest that, after i.v., but not intranasal, administration of MT-II, the activity of magnocellular neurones of the SON is increased. Because previous studies showed that SON oxytocin neurones are inhibited in response to direct application of melanocortin agonists, the actions of i.v. MT-II are likely to be mediated at least partly indirectly, possibly by activation of inputs from the caudal brainstem, where MT-II also increased Fos expression. © 2016 British Society for Neuroendocrinology.

BEETLE II: Deep Natural Language Understanding and Automatic Feedback Generation for Intelligent Tutoring in Basic Electricity and Electronics

ERIC Educational Resources Information Center

Dzikovska, Myroslava; Steinhauser, Natalie; Farrow, Elaine; Moore, Johanna; Campbell, Gwendolyn

2014-01-01

Within STEM domains, physics is considered to be one of the most difficult topics to master, in part because many of the underlying principles are counter-intuitive. Effective teaching methods rely on engaging the student in active experimentation and encouraging deep reasoning, often through the use of self-explanation. Supporting such…

County Agents for Children. Final Report. Part II. Helping Children Effectively. A Guide to Volunteers.

ERIC Educational Resources Information Center

George Peabody Coll. for Teachers, Nashville, TN. John F. Kennedy Center for Research on Education and Human Development.

Based on the experiences of a child advocacy project in Tennessee entitled County Agents for Children, the booklet presents a guide to help identify the needs of specific children, and to assist child advocate volunteers and other community personnel in meeting these needs. The focus is on children whose learning speed or physical development is…

Absence of Intervention Training Programs: Effects Upon the Severely and Profoundly Retarded, Part I: Selected Cases of Emotional and Behavioral Disturbances.

ERIC Educational Resources Information Center

Balthazar, Earl E.; And Others

Fifteen institutionalized profoundly retarded Ss, median age 7 years, who received no intervention training program, were assessed on the Balthazar Scales of Adaptive Behavior (BSAB), Sections I and II to determine whether social coping behavior would improve spontaneous maturation during a 6-month period. The Ss were recommended by nursing…

An ecological model of the habitat mosaic in estuarine nursery areas: Part II – Projecting effects of sea level rise on fish production

EPA Science Inventory

Understanding the response of fish populations to habitat change mediated by sea level rise (SLR) is a key component of ecosystem-based management. Yet, no direct link has been established between habitat change due to SLR and fish population production. Here we take a coupled ...

Part II: Multisystemic Therapy--Addressing Racial Disparity and Its Effectiveness with Families from Diverse Racial and Ethnic Backgrounds

ERIC Educational Resources Information Center

Painter, Kirstin; Scannapieco, Maria

2009-01-01

Disparities in health and mental health care delivered to racial and ethnic minorities became a focus of national policy following reports of the Institute of Medicine (IOM, 2002) and the Surgeon General (USDHHS, 2001). The Surgeon General (USDHHS, 2001) reported racial and ethnic minorities experience disparities in availability and quality of…

Can Animations Effectively Substitute for Traditional Teaching Methods? Part II: Potential for Differentiated Learning

ERIC Educational Resources Information Center

Gregorius, Roberto Ma.; Santos, Rhodora; Dano, Judith B.; Gutierrez, Jose J.

2010-01-01

Animations were prepared using Adobe Flash MX and tested on elementary (3rd-5th grade) and secondary chemistry students. A pre- and post-test study was used to compare the learning gains of students who received the animations with those who received textbook reading time and discussion in class. The control and experimental groups were further…

Behavior Intervention Teams: Examining Interventions with Community College Students Threatening Self-Harm

ERIC Educational Resources Information Center

Kramer-Jefferson, Kathryn R.

2017-01-01

Effective in 2011, The Department of Justice implemented a change to the direct threat standard, which is part of Title II of the Americans with Disabilities Act. This change removed the threat of harm to self from the direct threat standard and potentially limits the actions that colleges can take when working with and responding to students who…

20 CFR 408.950 - Will we accept a compromise settlement of an overpayment debt or suspend or terminate collection...

Code of Federal Regulations, 2010 CFR

2010-04-01

...' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Underpayments... (31 CFR 900.3 and parts 902 and 903). (c) Effect of compromise, suspension or termination. When we... accordance with provisions of the Social Security Act, other laws, and the standards set forth in 31 CFR...

Role of Assessment Tests in the Stability of Intelligence Scoring of Pre-School Children with Uneven/Delayed Cognitive Profile

ERIC Educational Resources Information Center

Yang, P.; Jong, Y-J.; Hsu, H-Y.; Lung, F-W.

2011-01-01

Background: As part of an ongoing clinical service programme for pre-school children with developmental delay in an Asian developing country, we analysed the effect of three assessment tests, that is, Bayley Scale of Infant Development-II, Leiter International Performance Scale-Revised and Wechsler Preschool and Primary Scale of…

Biogeochemical Cycles for Combining Chemical Knowledge and ESD Issues in Greek Secondary Schools Part II: Assessing the Impact of the Intervention

ERIC Educational Resources Information Center

Koutalidi, Sophia; Psallidas, Vassilis; Scoullos, Michael

2016-01-01

In searching for effective ways to combine science/chemical education with EE/ESD, new didactic materials were designed and produced focussing on biogeochemical cycles and their connection to sustainable development. The materials were experimentally applied in 16 Greek schools under the newly introduced compulsory "school project" which…

12 CFR 211.10 - Permissible activities abroad.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the BHC Act (12 U.S.C. 1843(a)(2)(A), (c)(1)(C)); (7) Holding the premises of a branch of an Edge or..., member bank, and Edge or agreement corporation qualify as well-capitalized and well-managed. (ii) Limits... activities prior to March 27, 1991, and subject to the limitations in effect at that time (See 12 CFR part...

12 CFR 211.10 - Permissible activities abroad.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the BHC Act (12 U.S.C. 1843(a)(2)(A), (c)(1)(C)); (7) Holding the premises of a branch of an Edge or..., member bank, and Edge or agreement corporation qualify as well-capitalized and well-managed. (ii) Limits... activities prior to March 27, 1991, and subject to the limitations in effect at that time (See 12 CFR part...

12 CFR 211.10 - Permissible activities abroad.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the BHC Act (12 U.S.C. 1843(a)(2)(A), (c)(1)(C)); (7) Holding the premises of a branch of an Edge or..., member bank, and Edge or agreement corporation qualify as well-capitalized and well-managed. (ii) Limits... activities prior to March 27, 1991, and subject to the limitations in effect at that time (See 12 CFR part...

Do Babies Matter (Part II)? Closing the Baby Gap

ERIC Educational Resources Information Center

Mason, Mary Ann; Goulden, Marc

2004-01-01

Even though women make up nearly half of the PhD population, they are not advancing at the same rate as men to the upper ranks of the professoriate; many are dropping out of the race. Our first "Do Babies Matter?" article, published in the November-December 2002 issue of Academe, examined the effect of family formation on academic careers. It was…

Maternal insulin-like growth factor-II promotes placental functional development via the type 2 IGF receptor in the guinea pig.

PubMed

Sferruzzi-Perri, A N; Owens, J A; Standen, P; Roberts, C T

2008-04-01

In guinea pigs, maternal insulin-like growth factor (IGF) infusion in early-pregnancy enhances placental transport near-term, increasing fetal growth and survival. The effects of IGF-II, but not IGF-I, appear due to enhanced placental labyrinthine (exchange) development. To determine if the type-2 IGF receptor (IGF2R) mediates these distinct actions of exogenous IGF-II in the mother, we compared the impact of IGF-II with an IGF-II analogue, Leu(27)-IGF-II, which only binds the IGF2R. IGF-II, Leu(27)-IGF-II (1mg/kg per day.sc) or vehicle were infused from days 20-38 of pregnancy (term = 67 days) and placental structure and uptake and transfer of [(3)H]-methyl-D-glucose (MG) and [(14)C]-amino-isobutyric acid (AIB) and fetal growth and plasma metabolites, were measured on day 62. Both IGF-II and Leu(27)-IGF-II increased the volume of placental labyrinth, trophoblast and maternal blood space within the labyrinth and total surface area of trophoblast for exchange, compared to vehicle. Leu(27)-IGF-II also reduced the barrier to diffusion (trophoblast thickness) compared to vehicle and IGF-II. Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. In addition, Leu(27)-IGF-II increased fetal weight compared to vehicle. In conclusion, maternal treatment with IGF-II or Leu(27)-IGF-II in early gestation, induce similar placental and fetal outcomes near term. This suggests that maternal IGF-II in early gestation acts in part via the IGF2R to persistently enhance placental functional development and nutrient delivery and promote fetal growth.

Development and implementation of online National Board Dental Examination Review Courses.

PubMed

Gadbury-Amyot, Cynthia C; Austin, Kylie Siruta; Overman, Pamela R

2013-12-01

Failure on the National Board Dental Examination (NBDE) Parts I and II has troubling consequences for dental students, faculty members, and school administrators. Since the NBDE is a high-stakes exam for all involved, it is important to determine effective strategies to help students prepare. The purpose of this article is to describe the development and implementation of online NBDE Parts I and II Review Courses by the faculty and administration at the University of Missouri-Kansas City School of Dentistry. The courses are taught by faculty members who are content experts. By utilizing distance technology, students in any geographic location can review the material at the time, place, and pace that are most convenient. Early outcomes show that 592 students from thirty-two states have participated in the courses since they were first offered in 2010-11. In post-course evaluations, students report that participation in the courses encouraged them to spend more time preparing for the exam and that the associated PowerPoint slides/handouts provided structure for their review. The literature suggests that multiple modalities are most effective in preparing for the NBDE. These online review courses can serve as a beneficial component of a student's preparation regimen.

Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats.

PubMed

Wang, Kai-Lee; Huang, Wen-Ching; Chou, Jou-Chun; Weng, Ting-Chun; Hu, Sindy; Lieu, Fu-Kong; Lai, Wei-Ho; Idova, Galina; Wang, Paulus S; Wang, Shyi-Wu

2016-07-01

A positive correlation between smoking and hypertension has been well established. Acrolein is a major toxic volatile compound found in cigarette smoke. Human exposure to low levels of acrolein is unavoidable due to its production in daily activities, such as smoke from industrial, hot oil cooking vapors, and exhaust fumes from vehicles. The toxicity and the action mechanism of acrolein to induce apoptosis have been extensively studied, but the effects of acrolein on hypertension are still unknown. The present study aimed to examine the effects of acrolein on aldosterone release both in vivo and in vitro. Male rats were divided into three groups, and intraperitoneally injected with normal saline, or acrolein (2mg/kg) for 1 (group A-1) or 3 (group A-3) days, respectively. After sacrificing, rat blood samples were obtained to measure plasma aldosterone and angiotensin II (Ang II) levels. Zona glomerulosa (ZG) cells were prepared from rat adrenal cortex, and were incubated with or without stimulants. We found that the serum aldosterone was increased by 1.2-fold (p<0.05) in A-3 group as compared to control group. Basal aldosterone release from ZG cells in A-3 group was also increased significantly. Moreover, acrolein enhanced the stimulatory effects of Ang II and 8-bromo-cyclic AMP on aldosterone secretion from ZG cells prepared in both A-1 and A-3 groups. Furthermore, the enzyme activity of P450scc, the rate-limiting step of aldosterone synthesis, was elevated after acrolein injection. Plasma level of Ang II was increased in both A-1 and A-3 groups. These results suggested that acrolein exposure increased aldosterone production, at least in part, through elevating the level of plasma Ang II and stimulating steroidogenesis pathways. Copyright © 2016 Elsevier Inc. All rights reserved.