Science.gov

Sample records for effective resistance metric

  1. Resisting anchoring effects: The roles of metric and mapping knowledge.

    PubMed

    Smith, Andrew R; Windschitl, Paul D

    2015-10-01

    The biasing influence of anchors on numerical estimates is well established, but the relationship between knowledge level and the susceptibility to anchoring effects is less clear. In two studies, we addressed the potential mitigating effects of having knowledge in a domain on vulnerability to anchoring effects in that domain. Of critical interest was a distinction between two forms of knowledge-metric and mapping knowledge. In Study 1, participants who had studied question-relevant information-that is, high-knowledge participants-were less influenced by anchors than were participants who had studied irrelevant information. The results from knowledge measures suggested that the reduction in anchoring was tied to increases in metric rather than mapping knowledge. In Study 2, participants studied information specifically designed to influence different types of knowledge. As we predicted, increases in metric knowledge-and not mapping knowledge-led to reduced anchoring effects. Implications for debiasing anchoring effects are discussed.

  2. Inspecting baby Skyrmions with effective metrics

    NASA Astrophysics Data System (ADS)

    Gibbons, G. W.; Goulart, E.

    2014-05-01

    In the present paper we investigate the causal structure of the baby Skyrme model using appropriate geometrical tools. We discuss several features of excitations propagating on top of background solutions and show that the evolution of high frequency waves is governed by a curved effective geometry. Examples are given for which the effective metric describes the interaction between waves and solitonic solutions such as kinks, antikinks, and hedgehogs. In particular, it is shown how violent processes involving the collisions of solitons and antisolitons may induce metrics which are not globally hyperbolic. We argue that it might be illuminating to calculate the effective metric as a diagnostic test for pathological regimes in numerical simulations.

  3. An Attentional Effect of Musical Metrical Structure

    PubMed Central

    Katz, Jonah; Chemla, Emmanuel; Pallier, Christophe

    2015-01-01

    Theories of metrical structure postulate the existence of several degrees of beat strength. While previous work has clearly established that humans are sensitive to the distinction between strong beats and weak ones, there is little evidence for a more fine grained distinction between intermediate levels. Here, we present experimental data showing that attention can be allocated to an intermediate level of beat strength. Comparing the effects of short exposures to 6/8 and 3/4 metrical structures on a tone detection task, we observe that subjects respond differently to beats of intermediate strength than to weak beats. PMID:26600180

  4. Quantum Hall Effect and Quillen Metric

    NASA Astrophysics Data System (ADS)

    Klevtsov, Semyon; Ma, Xiaonan; Marinescu, George; Wiegmann, Paul

    2017-02-01

    We study the generating functional, the adiabatic curvature and the adiabatic phase for the integer quantum Hall effect (QHE) on a compact Riemann surface. For the generating functional we derive its asymptotic expansion for the large flux of the magnetic field, i.e., for the large degree k of the positive Hermitian line bundle L k . The expansion consists of the anomalous and exact terms. The anomalous terms are the leading terms of the expansion. This part is responsible for the quantization of the adiabatic transport coefficients in QHE. We then identify the non-local (anomalous) part of the expansion with the Quillen metric on the determinant line bundle, and the subleading exact part with the asymptotics of the regularized spectral determinant of the Laplacian for the line bundle L k , at large k. Finally, we show how the generating functional of the integer QHE is related to the gauge and gravitational (2+1)d Chern-Simons functionals. We observe the relation between the Bismut-Gillet-Soulé curvature formula for the Quillen metric and the adiabatic curvature for the electromagnetic and geometric adiabatic transport of the integer Quantum Hall state. We then obtain the geometric part of the adiabatic phase in QHE, given by the Chern-Simons functional.

  5. Comparative study of line roughness metrics of chemically amplified and inorganic resists for EUV

    NASA Astrophysics Data System (ADS)

    Fallica, Roberto; Buitrago, Elizabeth; Ekinci, Yasin

    2016-03-01

    We present a comprehensive study of the roughness metrics of different resists. Dense line/space (L/S) images of polymethyl methacrylate (PMMA), hydrogen silsesquioxane (HSQ), different chemically amplified resists (CARs), and metal oxide based resists have been patterned by extreme ultraviolet interference lithography (EUV-IL). The three line width roughness metrics: r.m.s. value σLWR, correlation length ξ and roughness exponent α, were measured by metrological analysis of top down SEM images and compared for the different resists imaged here. It was found, that all metrics are required to fully describe the roughness of each resist. Our measurements indicate that few of the state-of-the- art resists tested here can meet the International Technology Roadmap for Semiconductors (ITRS) requirements for σLWR. The correlation length ξ has been found to be considerably higher in polymer-based materials in comparison to non-polymers. The roughness exponent α, interpreted using the concept of fractal geometry, is mainly affected by acid diffusion in CARs where it produces line edges with a higher complexity than in non-CAR resists. These results indicate that different resists platforms show very different LWR resist metrics and roughness is not only manifested in the σLWR but in all parameters. Therefore, all roughness metrics should be taken into account in the performance comparison of the resist, since they can have a substantial impact on the device performance.

  6. Comparative study of line roughness metrics of chemically amplified and inorganic resists for extreme ultraviolet

    NASA Astrophysics Data System (ADS)

    Fallica, Roberto; Buitrago, Elizabeth; Ekinci, Yasin

    2016-07-01

    We present a comprehensive comparative study of the roughness metrics of different resists. Dense line/space of polymethyl methacrylate, hydrogen silsesquioxane, a metal oxide-based resist, and different chemically amplified resists (CARs) have been patterned by extreme ultraviolet interference lithography. All three line width roughness (LWR) metrics: the root-mean-square (r.m.s.) roughness value σLWR, the correlation length ξ, and the roughness exponent α, were extracted by metrological analysis of top-down SEM images. We found that all metrics are required to fully describe the overall roughness of each resist. Our measurements indicate that in fact, a few of the state-of-the-art resists tested here can meet the International Technology Roadmap for Semiconductors requirements for σLWR. The correlation length ξ was also found to be considerably higher in polymer-based materials in comparison to nonpolymers. Finally, the roughness exponent α, interpreted using the concept of fractal geometry, was found to be mainly affected by acid diffusion in CARs, where it produces line edges with a higher complexity than in non-CAR resists. These results indicate that the different resists platforms show very different LWR metrics and roughness is not manifested only in the σLWR but in all parameters. Therefore, all roughness metrics should be taken into account when comparing the performance among different resists since they ultimately have a substantial impact on device performance.

  7. Coverage Metrics for Requirements-Based Testing: Evaluation of Effectiveness

    NASA Technical Reports Server (NTRS)

    Staats, Matt; Whalen, Michael W.; Heindahl, Mats P. E.; Rajan, Ajitha

    2010-01-01

    In black-box testing, the tester creates a set of tests to exercise a system under test without regard to the internal structure of the system. Generally, no objective metric is used to measure the adequacy of black-box tests. In recent work, we have proposed three requirements coverage metrics, allowing testers to objectively measure the adequacy of a black-box test suite with respect to a set of requirements formalized as Linear Temporal Logic (LTL) properties. In this report, we evaluate the effectiveness of these coverage metrics with respect to fault finding. Specifically, we conduct an empirical study to investigate two questions: (1) do test suites satisfying a requirements coverage metric provide better fault finding than randomly generated test suites of approximately the same size?, and (2) do test suites satisfying a more rigorous requirements coverage metric provide better fault finding than test suites satisfying a less rigorous requirements coverage metric? Our results indicate (1) only one coverage metric proposed -- Unique First Cause (UFC) coverage -- is sufficiently rigorous to ensure test suites satisfying the metric outperform randomly generated test suites of similar size and (2) that test suites satisfying more rigorous coverage metrics provide better fault finding than test suites satisfying less rigorous coverage metrics.

  8. Effective coverage: a metric for monitoring Universal Health Coverage.

    PubMed

    Ng, Marie; Fullman, Nancy; Dieleman, Joseph L; Flaxman, Abraham D; Murray, Christopher J L; Lim, Stephen S

    2014-09-01

    A major challenge in monitoring universal health coverage (UHC) is identifying an indicator that can adequately capture the multiple components underlying the UHC initiative. Effective coverage, which unites individual and intervention characteristics into a single metric, offers a direct and flexible means to measure health system performance at different levels. We view effective coverage as a relevant and actionable metric for tracking progress towards achieving UHC. In this paper, we review the concept of effective coverage and delineate the three components of the metric - need, use, and quality - using several examples. Further, we explain how the metric can be used for monitoring interventions at both local and global levels. We also discuss the ways that current health information systems can support generating estimates of effective coverage. We conclude by recognizing some of the challenges associated with producing estimates of effective coverage. Despite these challenges, effective coverage is a powerful metric that can provide a more nuanced understanding of whether, and how well, a health system is delivering services to its populations.

  9. Defining Attributes and Metrics of Effective Research Mentoring Relationships.

    PubMed

    Pfund, Christine; Byars-Winston, Angela; Branchaw, Janet; Hurtado, Sylvia; Eagan, Kevin

    2016-09-01

    Despite evidence of mentoring's importance in training researchers, studies to date have not yet determined which mentoring relationships have the most impact and what specific factors in those mentoring relationships contribute to key outcomes, such as the commitment to and persistence in research career paths for emerging researchers from diverse populations. Efforts to broaden participation and persistence in biomedical research careers require an understanding of why and how mentoring relationships work and their impact, not only to research training but also to promoting career advancement. This paper proposes core attributes of effective mentoring relationships, as supported by the literature and suggested by theoretical models of academic persistence. In addition, both existing and developing metrics for measuring the effectiveness of these attributes within mentoring relationships across diverse groups are presented, as well as preliminary data on these metrics from the authors' work.

  10. Effects of subsampling of passive acoustic recordings on acoustic metrics.

    PubMed

    Thomisch, Karolin; Boebel, Olaf; Zitterbart, Daniel P; Samaran, Flore; Van Parijs, Sofie; Van Opzeeland, Ilse

    2015-07-01

    Passive acoustic monitoring is an important tool in marine mammal studies. However, logistics and finances frequently constrain the number and servicing schedules of acoustic recorders, requiring a trade-off between deployment periods and sampling continuity, i.e., the implementation of a subsampling scheme. Optimizing such schemes to each project's specific research questions is desirable. This study investigates the impact of subsampling on the accuracy of two common metrics, acoustic presence and call rate, for different vocalization patterns (regimes) of baleen whales: (1) variable vocal activity, (2) vocalizations organized in song bouts, and (3) vocal activity with diel patterns. To this end, above metrics are compared for continuous and subsampled data subject to different sampling strategies, covering duty cycles between 50% and 2%. The results show that a reduction of the duty cycle impacts negatively on the accuracy of both acoustic presence and call rate estimates. For a given duty cycle, frequent short listening periods improve accuracy of daily acoustic presence estimates over few long listening periods. Overall, subsampling effects are most pronounced for low and/or temporally clustered vocal activity. These findings illustrate the importance of informed decisions when applying subsampling strategies to passive acoustic recordings or analyses for a given target species.

  11. The effect of measurement error on surveillance metrics

    SciTech Connect

    Weaver, Brian Phillip; Hamada, Michael S.

    2012-04-24

    The purpose of this manuscript is to describe different simulation studies that CCS-6 has performed for the purpose of understanding the effects of measurement error on the surveillance metrics. We assume that the measured items come from a larger population of items. We denote the random variable associate with an item's value of an attribute of interest as X and that X {approx} N({mu}, {sigma}{sup 2}). This distribution represents the variability in the population of interest and we wish to make inference on the parameters {mu} and {sigma} or on some function of these parameters. When an item X is selected from the larger population, a measurement is made on some attribute of it. This measurement is made with error and the true value of X is not observed. The rest of this section presents simulation results for different measurement cases encountered.

  12. Effects of quantum fluctuations of metric on the universe

    NASA Astrophysics Data System (ADS)

    Yang, Rongjia

    2016-09-01

    We consider a model of modified gravity from the nonperturbative quantization of a metric. We obtain the modified gravitational field equations and the modified conservational equations. We apply it to the FLRW spacetime and find that due to the quantum fluctuations a bounce universe can be obtained and a decelerated expansion can also possibly be obtained in a dark energy dominated epoch. We also discuss the effects of quantum fluctuations on inflation parameters (such as slow-roll parameters, spectral index, and the spectrum of the primordial curvature perturbation) and find values of parameters in the comparing the predictions of inflation can also work to drive the current epoch of acceleration. We obtain the constraints on the parameter of the theory from the observation of the big bang nucleosynthesis.

  13. Effecting IT infrastructure culture change: management by processes and metrics

    NASA Technical Reports Server (NTRS)

    Miller, R. L.

    2001-01-01

    This talk describes the processes and metrics used by Jet Propulsion Laboratory to bring about the required IT infrastructure culture change to update and certify, as Y2K compliant, thousands of computers and millions of lines of code.

  14. Network Metamodeling: Effect of Correlation Metric Choice on Phylogenomic and Transcriptomic Network Topology.

    PubMed

    Weighill, Deborah A; Jacobson, Daniel

    2017-01-10

    We explore the use of a network meta-modeling approach to compare the effects of similarity metrics used to construct biological networks on the topology of the resulting networks. This work reviews various similarity metrics for the construction of networks and various topology measures for the characterization of resulting network topology, demonstrating the use of these metrics in the construction and comparison of phylogenomic and transcriptomic networks.

  15. Network Metamodeling: The Effect of Correlation Metric Choice on Phylogenomic and Transcriptomic Network Topology

    SciTech Connect

    Weighill, Deborah A; Jacobson, Daniel A

    2017-01-01

    We explore the use of a network meta-modeling approach to compare the effects of similarity metrics used to construct biological networks on the topology of the resulting networks. This work reviews various similarity metrics for the construction of networks and various topology measures for the characterization of resulting network topology, demonstrating the use of these metrics in the construction and comparison of phylogenomic and transcriptomic networks.

  16. Development of Metrics to Evaluate Effectiveness of Emergency Response Operations

    DTIC Science & Technology

    2005-06-01

    00-00-2005 4. TITLE AND SUBTITLE Development of Metrics to Evaluate Efectiveness of Emergency Response Operations 5a. CONTRACT NUMBER 5b. GRANT...population and/or property. Furthermore, the disaster will be characterized as being large enough that the resources the community has to mitigate the...disaster are stretched beyond the limits of their capacity. Such events that a community can readily cope with, such as small fires, individual

  17. Helical Emg Effective Resistance

    NASA Astrophysics Data System (ADS)

    Chernyshev, V. K.; Zharinov, E. I.; Busin, V. N.; Grinevich, B. E.; Sokolova, O. V.; Smirnova, G. N.; Klimushkin, K. N.

    2004-11-01

    The efficiency of explosive-magnetic system operation depends on the magnetic flux losses produced under circuit deformation. Losses primarily arise from circuit ohmic resistance and flux pocketing due to the disturbed continuity of helix wires deformation. This is because of technological faults in fabrication and potential electric breakdowns resulting from the voltage overload in the generator circuit. Since it is rather difficult to identify each type of loss mentioned, all soles are expressed as the effective resistance of the circuit, Reff. The EMG-160 multi-sectional helical generator with a 760 mm long helix having an inner diameter of 160 mm is considered as an example. EMG-160 initial conductance was 34 μH and the final inductance was 25 nH. The effective resistance of the circuit was calculated for this experiment. The method of determining the effective resistance allows estimation of EMG efficiency at all stages of generator operation.

  18. Think Metric

    USGS Publications Warehouse

    ,

    1978-01-01

    The International System of Units, as the metric system is officially called, provides for a single "language" to describe weights and measures over the world. We in the United States together with the people of Brunei, Burma, and Yemen are the only ones who have not put this convenient system into effect. In the passage of the Metric Conversion Act of 1975, Congress determined that we also will adopt it, but the transition will be voluntary.

  19. Using community-level metrics to monitor the effects of marine protected areas on biodiversity.

    PubMed

    Soykan, Candan U; Lewison, Rebecca L

    2015-06-01

    Marine protected areas (MPAs) are used to protect species, communities, and their associated habitats, among other goals. Measuring MPA efficacy can be challenging, however, particularly when considering responses at the community level. We gathered 36 abundance and 14 biomass data sets on fish assemblages and used meta-analysis to evaluate the ability of 22 distinct community diversity metrics to detect differences in community structure between MPAs and nearby control sites. We also considered the effects of 6 covariates-MPA size and age, MPA size and age interaction, latitude, total species richness, and level of protection-on each metric. Some common metrics, such as species richness and Shannon diversity, did not differ consistently between MPA and control sites, whereas other metrics, such as total abundance and biomass, were consistently different across studies. Metric responses derived from the biomass data sets were more consistent than those based on the abundance data sets, suggesting that community-level biomass differs more predictably than abundance between MPA and control sites. Covariate analyses indicated that level of protection, latitude, MPA size, and the interaction between MPA size and age affect metric performance. These results highlight a handful of metrics, several of which are little known, that could be used to meet the increasing demand for community-level indicators of MPA effectiveness.

  20. [Applicability of traditional landscape metrics in evaluating urban heat island effect].

    PubMed

    Chen, Ai-Lian; Sun, Ran-Hao; Chen, Li-Ding

    2012-08-01

    By using 24 landscape metrics, this paper evaluated the urban heat island effect in parts of Beijing downtown area. QuickBird (QB) images were used to extract the landscape type information, and the thermal bands from Landsat Enhanced Thematic Mapper Plus (ETM+) images were used to extract the land surface temperature (LST) in four seasons of the same year. The 24 landscape pattern metrics were calculated at landscape and class levels in a fixed window with 120 mx 120 m in size, with the applicability of these traditional landscape metrics in evaluating the urban heat island effect examined. Among the 24 landscape metrics, only the percentage composition of landscape (PLAND), patch density (PD), largest patch index (LPI), coefficient of Euclidean nearest-neighbor distance variance (ENN_CV), and landscape division index (DIVISION) at landscape level were significantly correlated with the LST in March, May, and November, and the PLAND, LPI, DIVISION, percentage of like adjacencies, and interspersion and juxtaposition index at class level showed significant correlations with the LST in March, May, July, and December, especially in July. Some metrics such as PD, edge density, clumpiness index, patch cohesion index, effective mesh size, splitting index, aggregation index, and normalized landscape shape index showed varying correlations with the LST at different class levels. The traditional landscape metrics could not be appropriate in evaluating the effects of river on LST, while some of the metrics could be useful in characterizing urban LST and analyzing the urban heat island effect, but screening and examining should be made on the metrics.

  1. Effect of quality metric monitoring and colonoscopy performance

    PubMed Central

    Razzak, Anthony; Smith, Dineen; Zahid, Maliha; Papachristou, Georgios; Khalid, Asif

    2016-01-01

    Background and aims: Adenoma detection rate (ADR) and cecal withdrawal time (CWT) have been identified as measures of colonoscopy quality. This study evaluates the impact of monitoring these measures on provider performance. Methods: Six blinded gastroenterologists practicing at a Veterans Affairs Medical Center were prospectively monitored over 9 months. Data for screening, adenoma surveillance, and fecal occult blood test positive (FOBT +) indicated colonoscopies were obtained, including exam preparation quality, cecal intubation rate, CWT, ADR, adenomas per colonoscopy (APC), and adverse events. Metrics were continuously monitored after a period of informed CWT monitoring and informed CWT + ADR monitoring. The primary outcome was impact on ADR and APC. Results: A total of 1671 colonoscopies were performed during the study period with 540 before informed monitoring, 528 during informed CWT monitoring, and 603 during informed CWT + ADR monitoring. No statistically significant impact on ADR was noted across each study phase. Multivariate regression revealed a trend towards fewer adenomas removed during the CWT monitoring phase (OR = 0.79; 95 %CI 0.62 – 1.02, P = 0.065) and a trend towards more adenomas removed during the CWT + ADR monitoring phase when compared to baseline (OR = 1.26; 95 %CI 0.99 – 1.61, P = 0.062). Indication for examination and provider were significant predictors for higher APC. Provider-specific data demonstrated a direct relationship between high ADR performers and increased CWT. Conclusions: Monitoring quality metrics did not significantly alter colonoscopy performance across a small heterogeneous group of providers. Non-significant trends towards higher APC were noted with CWT + ADR monitoring. Providers with a longer CWT had a higher ADR. Further studies are needed to determine the impact of monitoring on colonoscopy performance. PMID:27747273

  2. Navy Needs to Establish Effective Metrics to Achieve Desired Outcomes for SPY1 Radar Sustainment (Redacted)

    DTIC Science & Technology

    2016-08-01

    incorporated into the follow-on PBL contracts and the fleet’s SPY-1 radar sustainment needs are met without a formal agreement binding ATAC to deliver...Phased Array Radar (SPY-1 radar) performance-based logistics contracts appropriately incentivized the support contractors. This audit is the second in...metrics into the performance-based logistics contracts used to sustain SPY-1 radars. Specifically, the metrics did not effectively incentivize

  3. On the Doppler effect for light from orbiting sources in Kerr-type metrics

    NASA Astrophysics Data System (ADS)

    Cisneros, S.; Goedecke, G.; Beetle, C.; Engelhardt, M.

    2015-04-01

    A formula is derived for the combined motional and gravitational Doppler effect in general stationary axisymmetric metrics for a photon emitted parallel or antiparallel to the assumed circular orbital motion of its source. The same formula is derived by both the eikonal approximation and Killing vector approaches to elucidate connections between observational astronomy and modern relativity. The formula yields expected results in the limits of a moving or stationary source in the exterior Kerr and Schwarzschild metrics and is useful for broad range astrophysical analyses.

  4. Development of Performance and Effectiveness Metrics For Mechanical Diagnostic Technologies

    DTIC Science & Technology

    2001-04-05

    this need , a virtual test bench is under development by the Navy for assessing the performance and effectiveness of machinery diagnostic systems. The...benefits of mechanical machinery diagnostic technologies does not currently exist. In response to this need , a virtual test bench is 375 under...thermocouples, acoustic emission sensors, and oil debris sensors. Tests are run at various load and speed profiles while 381 logging measurement signals for

  5. Metrics to describe the effects of landscape pattern on hydrology in a lotic peatland

    NASA Astrophysics Data System (ADS)

    Yuan, J.; Cohen, M. J.; Kaplan, D. A.; Acharya, S.; Larsen, L.; Nungesser, M.

    2013-12-01

    Strong reciprocal interactions exist between landscape patterns and ecological processes. Hydrology is the dominant abiotic driver of ecological processes in wetlands, particularly flowing wetlands, but is both the control on and controlled by the geometry of vegetation patterning. Landscape metrics are widely used to quantitatively link pattern and process. Our goal here was to use several candidate spatial pattern metrics to predict the effects of wetland vegetation pattern on hydrologic regime, specifically hydroperiod, in the ridge-slough patterned landscape of the Everglades. The metrics focus on the capacity for longitudinally connected flow, and thus the ability of this low-gradient patterned landscape to route water from upstream. We first explored flow friction cost (FFC), a weighted spatial distance procedure wherein ridges have a high flow cost than sloughs by virtue of their elevation and vegetation structure, to evaluate water movement through different landscape configurations. We also investigated existing published flow metrics, specifically the Directional Connectivity Index (DCI) and Landscape Discharge Competence (LDC), that seek to quantify connectivity, one of the sentinel targets of ecological restoration. Hydroperiod was estimated using a numerical hydrologic model (SWIFT 2D) in real and synthetic landscapes with varying vegetation properties ( patch anisotropy, ridge density). Synthetic landscapes were constrained by the geostatistical properties of the best conserved patterned, and contained five anisotropy levels and seven ridge density levels. These were used to construct the relationship between landscape metrics and hydroperiod. Then, using historical images from 1940 to 2004, we applied the metrics toback-cast hydroperiod. Current vegetation maps were used to test scale dependency for each metric. Our results suggest that both FFC and DCI are good predictors of hydroperiod under free flowing conditions, and that they can be used

  6. Effectively identifying user profiles in network and host metrics

    NASA Astrophysics Data System (ADS)

    Murphy, John P.; Berk, Vincent H.; Gregorio-de Souza, Ian

    2010-04-01

    This work presents a collection of methods that is used to effectively identify users of computers systems based on their particular usage of the software and the network. Not only are we able to identify individual computer users by their behavioral patterns, we are also able to detect significant deviations in their typical computer usage over time, or compared to a group of their peers. For instance, most people have a small, and relatively unique selection of regularly visited websites, certain email services, daily work hours, and typical preferred applications for mandated tasks. We argue that these habitual patterns are sufficiently specific to identify fully anonymized network users. We demonstrate that with only a modest data collection capability, profiles of individual computer users can be constructed so as to uniquely identify a profiled user from among their peers. As time progresses and habits or circumstances change, the methods presented update each profile so that changes in user behavior can be reliably detected over both abrupt and gradual time frames, without losing the ability to identify the profiled user. The primary benefit of our methodology allows one to efficiently detect deviant behaviors, such as subverted user accounts, or organizational policy violations. Thanks to the relative robustness, these techniques can be used in scenarios with very diverse data collection capabilities, and data privacy requirements. In addition to behavioral change detection, the generated profiles can also be compared against pre-defined examples of known adversarial patterns.

  7. Effect of respiratory and cardiac gating on the major diffusion-imaging metrics.

    PubMed

    Hamaguchi, Hiroyuki; Tha, Khin Khin; Sugimori, Hiroyuki; Nakanishi, Mitsuhiro; Nakagawa, Shin; Fujiwara, Taro; Yoshida, Hirokazu; Takamori, Sayaka; Shirato, Hiroki

    2016-08-01

    The effect of respiratory gating on the major diffusion-imaging metrics and that of cardiac gating on mean kurtosis (MK) are not known. For evaluation of whether the major diffusion-imaging metrics-MK, fractional anisotropy (FA), and mean diffusivity (MD) of the brain-varied between gated and non-gated acquisitions, respiratory-gated, cardiac-gated, and non-gated diffusion-imaging of the brain were performed in 10 healthy volunteers. MK, FA, and MD maps were constructed for all acquisitions, and the histograms were constructed. The normalized peak height and location of the histograms were compared among the acquisitions by use of Friedman and post hoc Wilcoxon tests. The effect of the repetition time (TR) on the diffusion-imaging metrics was also tested, and we corrected for its variation among acquisitions, if necessary. The results showed a shift in the peak location of the MK and MD histograms to the right with an increase in TR (p ≤ 0.01). The corrected peak location of the MK histograms, the normalized peak height of the FA histograms, the normalized peak height and the corrected peak location of the MD histograms varied significantly between the gated and non-gated acquisitions (p < 0.05). These results imply an influence of respiration and cardiac pulsation on the major diffusion-imaging metrics. The gating conditions must be kept identical if reproducible results are to be achieved.

  8. Effective resist profile control

    NASA Astrophysics Data System (ADS)

    Liu, Chen-Yu; Wang, Chien-Wei; Huang, Chun-Ching; Chang, Ching-Yu; Ku, Yao-Ching

    2014-03-01

    To meet Moore's law, resist resolution improvement has become more and more important. However, it is difficult to improve resist resolution and keep vertical sidewall profile. For example, a high contrast hole resist may cause trench scum, due to very T-top profile. This paper reports several concepts for resist profile tuning without losing performance for lithographic factor , including mask error enhancement factor (MEEF), depth of focus (DOF), and critical dimension uniformity (CDU). To quantitative analysis the resist profile improvement, we define a new factor, Scum fail ratio (F/R%) for new techniques evaluation. The new techniques, including floatable additive, floatable PAG, and new monomer, are discussed. From X-SEM and CD-SEM data, former three concepts could improve resist sidewall profile quantitatively evaluated by Scum fail F/R% and keep lithographic factors. In addition, another key factor, resist residue defect, is also discussed. The high contrast resist with higher receding contact angle (RCA) easily generates more residue defect after development. With the new monomer composition, RCA of Resist E is decreased from 54 to 48 degree after development. Therefore, the residue defect is improved one order.

  9. The Use of Performance Metrics for the Assessment of Safeguards Effectiveness at the State Level

    SciTech Connect

    Bachner K. M.; George Anzelon, Lawrence Livermore National Laboratory, Livermore, CA Yana Feldman, Lawrence Livermore National Laboratory, Livermore, CA Mark Goodman,Department of State, Washington, DC Dunbar Lockwood, National Nuclear Security Administration, Washington, DC Jonathan B. Sanborn, JBS Consulting, LLC, Arlington, VA.

    2016-07-24

    In the ongoing evolution of International Atomic Energy Agency (IAEA) safeguards at the state level, many safeguards implementation principles have been emphasized: effectiveness, efficiency, non-discrimination, transparency, focus on sensitive materials, centrality of material accountancy for detecting diversion, independence, objectivity, and grounding in technical considerations, among others. These principles are subject to differing interpretations and prioritizations and sometimes conflict. This paper is an attempt to develop metrics and address some of the potential tradeoffs inherent in choices about how various safeguards policy principles are implemented. The paper carefully defines effective safeguards, including in the context of safeguards approaches that take account of the range of state-specific factors described by the IAEA Secretariat and taken note of by the Board in September 2014, and (2) makes use of performance metrics to help document, and to make transparent, how safeguards implementation would meet such effectiveness requirements.

  10. Mediterranean dryland Mosaic: The effect of scale on core area metrics

    NASA Astrophysics Data System (ADS)

    Alhamad, Mohammad Noor; Alrababah, Mohammad

    2014-05-01

    Quantifying landscape spatial pattern is essential to understanding the relationship between landscape structure and ecological functions and process. Many landscape metrics have been developed to quantify spatial heterogeneity. Landscape metrics have been employed to measure the impact of humans on landscapes. We examined the response of four core areas metrics to a large range of grain sizes in Mediterranean dryland landscapes. The investigated metrics were (1) mean core area (CORE-MN), (2) area weighted mean core area (CORE-AM) , (3) total core area (TCA) and (4) core area percentage of landscape (CPLAND) within six land use types (urban, agriculture, olive orchids, forestry, shrubland and rangeland). Agriculture areas showed the highest value for minimum TCA (2779.4 ha) within the tested grain sizes, followed by rangeland (1778.3 ha) and Forest (1488.5 ha). On the other hand, shrubland showed the lowest TCA (8.0 ha). The minimum CPLAND values were ranged from 0.002 for shrubland to 0.682 for agriculture land use. The maximum CORE-MN among the tested land use type at all levels of grain sizes was exhibited by agriculture land use type (519.759 ha). The core area metrics showed three types of behavior in response to changing grain size in all landuse types. CORE-MN showed predictable relationship, best explained by non-linear responses to changing grain size (R2=0.99). Both TCA and CPLAND exhibited domain of scale effect in response to changing grain size. The threshold behavior for TCA and CPLAND was at the 4 x 4 grain size (about 1.3 ha). However, CORE-AM exhibited erratic behavior. The unique domain of scale-like behavior may be attributed to the unique characteristics of dryland Mediterranean landscapes; where both natural processes and ancient human activities play a great role in shaping the apparent pattern of the landscape

  11. Effects of certain key metrics of hydroentanglement system on properties of nonwoven fabrics made with commercially cleaned greige cotton

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Research was conducted to determine the effects of certain key process metrics of a commercial-grade hydroentanglement system on properties of the nonwoven fabrics made with cleaned Upland greige cotton lint. The metrics studied, among others, were the hydroentangling water pressure, the strip orif...

  12. Color Metric.

    ERIC Educational Resources Information Center

    Illinois State Office of Education, Springfield.

    This booklet was designed to convey metric information in pictoral form. The use of pictures in the coloring book enables the more mature person to grasp the metric message instantly, whereas the younger person, while coloring the picture, will be exposed to the metric information long enough to make the proper associations. Sheets of the booklet…

  13. Effects of metric change on safety in the workplace for selected occupations

    NASA Astrophysics Data System (ADS)

    Lefande, J. M.; Pokorney, J. L.

    1982-04-01

    The study assesses the potential safety issues of metric conversion in the workplace. A purposive sample of 35 occupations based on injury and illnesses indexes were assessed. After an analysis of workforce population, hazard analysis and measurement sensitivity of the occupations, jobs were analyzed to identify potential safety hazards by industrial hygienists, safety engineers and academia. The study's major findings were as follows: No metric hazard experience was identified. An increased exposure might occur when particular jobs and their job tasks are going the transition from customary measurement to metric measurement. Well planned metric change programs reduce hazard potential. Metric safety issues are unresolved in the aviation industry.

  14. Assessing the Effects of Data Compression in Simulations Using Physically Motivated Metrics

    DOE PAGES

    Laney, Daniel; Langer, Steven; Weber, Christopher; ...

    2014-01-01

    This paper examines whether lossy compression can be used effectively in physics simulations as a possible strategy to combat the expected data-movement bottleneck in future high performance computing architectures. We show that, for the codes and simulations we tested, compression levels of 3–5X can be applied without causing significant changes to important physical quantities. Rather than applying signal processing error metrics, we utilize physics-based metrics appropriate for each code to assess the impact of compression. We evaluate three different simulation codes: a Lagrangian shock-hydrodynamics code, an Eulerian higher-order hydrodynamics turbulence modeling code, and an Eulerian coupled laser-plasma interaction code. Wemore » compress relevant quantities after each time-step to approximate the effects of tightly coupled compression and study the compression rates to estimate memory and disk-bandwidth reduction. We find that the error characteristics of compression algorithms must be carefully considered in the context of the underlying physics being modeled.« less

  15. Comparing Single Case Design Overlap-Based Effect Size Metrics From Studies Examining Speech Generating Device Interventions

    PubMed Central

    Chen, Mo; Hyppa-Martin, Jolene K.; Reichle, Joe E.; Symons, Frank J.

    2017-01-01

    Meaningfully synthesizing single case experimental data from intervention studies comprised of individuals with low incidence conditions and generating effect size estimates remains challenging. Seven effect size metrics were compared for single case design (SCD) data focused on teaching speech generating device use to individuals with intellectual and developmental disabilities (IDD) with moderate to profound levels of impairment. The effect size metrics included percent of data points exceeding the median (PEM), percent of nonoverlapping data (PND), improvement rate difference (IRD), percent of all nonoverlapping data (PAND), Phi, nonoverlap of all pairs (NAP), and Taunovlap. Results showed that among the seven effect size metrics, PAND, Phi, IRD, and PND were more effective in quantifying intervention effects for the data sample (N = 285 phase or condition contrasts). Results are discussed with respect to issues concerning extracting and calculating effect sizes, visual analysis, and SCD intervention research in IDD. PMID:27119210

  16. Forensic Metrics

    ERIC Educational Resources Information Center

    Bort, Nancy

    2005-01-01

    One of the most important review topics the author teaches in middle school is the use of metric measurement for problem solving and inquiry. For many years, she had students measuring various objects around the room using the tools of metric measurement. She dutifully taught hypothesizing, data collecting, and drawing conclusions. It was…

  17. Mastering Metrics

    ERIC Educational Resources Information Center

    Parrot, Annette M.

    2005-01-01

    By the time students reach a middle school science course, they are expected to make measurements using the metric system. However, most are not practiced in its use, as their experience in metrics is often limited to one unit they were taught in elementary school. This lack of knowledge is not wholly the fault of formal education. Although the…

  18. Topics in Metric Approximation

    NASA Astrophysics Data System (ADS)

    Leeb, William Edward

    This thesis develops effective approximations of certain metrics that occur frequently in pure and applied mathematics. We show that distances that often arise in applications, such as the Earth Mover's Distance between two probability measures, can be approximated by easily computed formulas for a wide variety of ground distances. We develop simple and easily computed characterizations both of norms measuring a function's regularity -- such as the Lipschitz norm -- and of their duals. We are particularly concerned with the tensor product of metric spaces, where the natural notion of regularity is not the Lipschitz condition but the mixed Lipschitz condition. A theme that runs throughout this thesis is that snowflake metrics (metrics raised to a power less than 1) are often better-behaved than ordinary metrics. For example, we show that snowflake metrics on finite spaces can be approximated by the average of tree metrics with a distortion bounded by intrinsic geometric characteristics of the space and not the number of points. Many of the metrics for which we characterize the Lipschitz space and its dual are snowflake metrics. We also present applications of the characterization of certain regularity norms to the problem of recovering a matrix that has been corrupted by noise. We are able to achieve an optimal rate of recovery for certain families of matrices by exploiting the relationship between mixed-variable regularity conditions and the decay of a function's coefficients in a certain orthonormal basis.

  19. Spectrum splitting metrics and effect of filter characteristics on photovoltaic system performance.

    PubMed

    Russo, Juan M; Zhang, Deming; Gordon, Michael; Vorndran, Shelby; Wu, Yuechen; Kostuk, Raymond K

    2014-03-10

    During the past few years there has been a significant interest in spectrum splitting systems to increase the overall efficiency of photovoltaic solar energy systems. However, methods for comparing the performance of spectrum splitting systems and the effects of optical spectral filter design on system performance are not well developed. This paper addresses these two areas. The system conversion efficiency is examined in detail and the role of optical spectral filters with respect to the efficiency is developed. A new metric termed the Improvement over Best Bandgap is defined which expresses the efficiency gain of the spectrum splitting system with respect to a similar system that contains the highest constituent single bandgap photovoltaic cell. This parameter indicates the benefit of using the more complex spectrum splitting system with respect to a single bandgap photovoltaic system. Metrics are also provided to assess the performance of experimental spectral filters in different spectrum splitting configurations. The paper concludes by using the methodology to evaluate spectrum splitting systems with different filter configurations and indicates the overall efficiency improvement that is possible with ideal and experimental designs.

  20. Detecting the effects of cascade hydropower reservoirs on eco-flow metrics

    NASA Astrophysics Data System (ADS)

    Zhao, T.; Zhao, J.

    2012-12-01

    Over evolutionary time, the natural hydrological events of floods and droughts have become an integral component of riverine ecosystems. However, human activities, particularly reservoir operations, can greatly alter the natural flow regime and pose great impacts on riverine ecosystems. This study analyses the effects of cascade hydropower reservoir operation on eco-flow metrics based on inflow and release data of reservoirs in southwest China, with a focus on the Xiaowan reservoir (upper reservoir with multi-annual storage capacity) and the Jinghong reservoir (lower reservoir with weekly storage capacity). For the upper Xiaowan Reservoir, the analysis results show that the eco-surplus and eco-deficit (Vogel, et al, 2007; Gao, et al., 2009 ) can capture its impacts of hydropower operation on eco-flow metrics very well. However, comparative analysis of the lower Jinghong reservoir based on daily and hourly data shows that eco-surplus and eco-deficit measured with flow duration curve of daily and hourly flow data are not sensitive indices, which is attributed to the small regulating capacity of the Jinghong reservoir. It is shown that the negative impacts of hydropower operation of the Jinghong reservoir can be characterized by the changing rate of flow. These results indicate that eco-surplus and eco-deficit are good representative indices for evaluating seasonal reservoir operation, but more attention should be paid to the changing rate of flow for short term hydropower reservoir operation. This study implies that coordination of cascade reservoirs can be an effective way to mitigate the negative impacts of hydropower operation on ecosystem.

  1. Comparing Single Case Design Overlap-Based Effect Size Metrics from Studies Examining Speech Generating Device Interventions

    ERIC Educational Resources Information Center

    Chen, Mo; Hyppa-Martin, Jolene K.; Reichle, Joe E.; Symons, Frank J.

    2016-01-01

    Meaningfully synthesizing single case experimental data from intervention studies comprised of individuals with low incidence conditions and generating effect size estimates remains challenging. Seven effect size metrics were compared for single case design (SCD) data focused on teaching speech generating device use to individuals with…

  2. Evaluating Texture Compression Masking Effects Using Objective Image Quality Assessment Metrics.

    PubMed

    Griffin, Wesley; Olano, Marc

    2015-08-01

    Texture compression is widely used in real-time rendering to reduce storage and bandwidth requirements. Recent research in compression algorithms has explored both reduced fixed bit rate and variable bit rate algorithms. The results are evaluated at the individual texture level using mean square error, peak signal-to-noise ratio, or visual image inspection. We argue this is the wrong evaluation approach. Compression artifacts in individual textures are likely visually masked in final rendered images and this masking is not accounted for when evaluating individual textures. This masking comes from both geometric mapping of textures onto models and the effects of combining different textures on the same model such as diffuse, gloss, and bump maps. We evaluate final rendered images using rigorous perceptual error metrics. Our method samples the space of viewpoints in a scene, renders the scene from each viewpoint using variations of compressed textures, and then compares each to a ground truth using uncompressed textures from the same viewpoint. We show that masking has a significant effect on final rendered image quality, masking effects and perceptual sensitivity to masking varies by the type of texture, graphics hardware compression algorithms are too conservative, and reduced bit rates are possible while maintaining final rendered image quality.

  3. Cyber threat metrics.

    SciTech Connect

    Frye, Jason Neal; Veitch, Cynthia K.; Mateski, Mark Elliot; Michalski, John T.; Harris, James Mark; Trevino, Cassandra M.; Maruoka, Scott

    2012-03-01

    Threats are generally much easier to list than to describe, and much easier to describe than to measure. As a result, many organizations list threats. Fewer describe them in useful terms, and still fewer measure them in meaningful ways. This is particularly true in the dynamic and nebulous domain of cyber threats - a domain that tends to resist easy measurement and, in some cases, appears to defy any measurement. We believe the problem is tractable. In this report we describe threat metrics and models for characterizing threats consistently and unambiguously. The purpose of this report is to support the Operational Threat Assessment (OTA) phase of risk and vulnerability assessment. To this end, we focus on the task of characterizing cyber threats using consistent threat metrics and models. In particular, we address threat metrics and models for describing malicious cyber threats to US FCEB agencies and systems.

  4. What is "fallback"?: metrics needed to assess telemetry tag effects on anadromous fish behavior

    USGS Publications Warehouse

    Frank, Holly J.; Mather, Martha E.; Smith, Joseph M.; Muth, Robert M.; Finn, John T.; McCormick, Stephen D.

    2009-01-01

    Telemetry has allowed researchers to document the upstream migrations of anadromous fish in freshwater. In many anadromous alosine telemetry studies, researchers use downstream movements (“fallback”) as a behavioral field bioassay for adverse tag effects. However, these downstream movements have not been uniformly reported or interpreted. We quantified movement trajectories of radio-tagged anadromous alewives (Alosa pseudoharengus) in the Ipswich River, Massachusetts (USA) and tested blood chemistry of tagged and untagged fish held 24 h. A diverse repertoire of movements was observed, which could be quantified using (a) direction of initial movements, (b) timing, and (c) characteristics of bouts of coupled upstream and downstream movements (e.g., direction, distance, duration, and speed). Because downstream movements of individual fish were almost always made in combination with upstream movements, these should be examined together. Several of the movement patterns described here could fall under the traditional definition of “fallback” but were not necessarily aberrant. Because superficially similar movements could have quite different interpretations, post-tagging trajectories need more precise definitions. The set of metrics we propose here will help quantify tag effects in the field, and provide the basis for a conceptual framework that helps define the complicated behaviors seen in telemetry studies on alewives and other fish in the field.

  5. Metric qualities of the cognitive behavioral assessment for outcome evaluation to estimate psychological treatment effects

    PubMed Central

    Bertolotti, Giorgio; Michielin, Paolo; Vidotto, Giulio; Sanavio, Ezio; Bottesi, Gioia; Bettinardi, Ornella; Zotti, Anna Maria

    2015-01-01

    Background Cognitive behavioral assessment for outcome evaluation was developed to evaluate psychological treatment interventions, especially for counseling and psychotherapy. It is made up of 80 items and five scales: anxiety, well-being, perception of positive change, depression, and psychological distress. The aim of the study was to present the metric qualities and to show validity and reliability of the five constructs of the questionnaire both in nonclinical and clinical subjects. Methods Four steps were completed to assess reliability and factor structure: criterion-related and concurrent validity, responsiveness, and convergent–divergent validity. A nonclinical group of 269 subjects was enrolled, as was a clinical group comprising 168 adults undergoing psychotherapy and psychological counseling provided by the Italian public health service. Results Cronbach’s alphas were between 0.80 and 0.91 for the clinical sample and between 0.74 and 0.91 in the nonclinical one. We observed an excellent structural validity for the five interrelated dimensions. The clinical group showed higher scores in the anxiety, depression, and psychological distress scales, as well as lower scores in well-being and perception of positive change scales than those observed in the nonclinical group. Responsiveness was large for the anxiety, well-being, and depression scales; the psychological distress and perception of positive change scales showed a moderate effect. Conclusion The questionnaire showed excellent psychometric properties, thus demonstrating that the questionnaire is a good evaluative instrument, with which to assess pre- and post-treatment outcomes. PMID:26442466

  6. Effects of noise suppression on intelligibility. II: An attempt to validate physical metrics.

    PubMed

    Hilkhuysen, Gaston; Gaubitch, Nikolay; Brookes, Mike; Huckvale, Mark

    2014-01-01

    Using the data presented in the accompanying paper [Hilkhuysen et al., J. Acoust. Soc. Am. 131, 531-539 (2012)], the ability of six metrics to predict intelligibility of speech in noise before and after noise suppression was studied. The metrics considered were the Speech Intelligibility Index (SII), the fractional Articulation Index (fAI), the coherence intelligibility index based on the mid-levels in speech (CSIImid), an extension of the Normalized Coherence Metric (NCM+), a part of the speech-based envelope power model (pre-sEPSM), and the Short Term Objective Intelligibility measure (STOI). Three of the measures, SII, CSIImid, and NCM+, overpredicted intelligibility after noise reduction, whereas fAI underpredicted these intelligibilities. The pre-sEPSM metric worked well for speech in babble but failed with car noise. STOI gave the best predictions, but overall the size of intelligibility prediction errors were greater than the change in intelligibility caused by noise suppression. Suggestions for improvements of the metrics are discussed.

  7. Fault Management Metrics

    NASA Technical Reports Server (NTRS)

    Johnson, Stephen B.; Ghoshal, Sudipto; Haste, Deepak; Moore, Craig

    2017-01-01

    This paper describes the theory and considerations in the application of metrics to measure the effectiveness of fault management. Fault management refers here to the operational aspect of system health management, and as such is considered as a meta-control loop that operates to preserve or maximize the system's ability to achieve its goals in the face of current or prospective failure. As a suite of control loops, the metrics to estimate and measure the effectiveness of fault management are similar to those of classical control loops in being divided into two major classes: state estimation, and state control. State estimation metrics can be classified into lower-level subdivisions for detection coverage, detection effectiveness, fault isolation and fault identification (diagnostics), and failure prognosis. State control metrics can be classified into response determination effectiveness and response effectiveness. These metrics are applied to each and every fault management control loop in the system, for each failure to which they apply, and probabilistically summed to determine the effectiveness of these fault management control loops to preserve the relevant system goals that they are intended to protect.

  8. Effects of Common Data Errors in Electronic Health Records on Emergency Department Operational Performance Metrics: A Monte Carlo Simulation

    PubMed Central

    Ward, Michael J.; Self, Wesley H.; Froehle, Craig M.

    2015-01-01

    Objectives To estimate how data errors in electronic health records (EHR) can affect the accuracy of common emergency department (ED) operational performance metrics. Methods Using a 3-month, 7,348-visit dataset of electronic timestamps from a suburban academic ED as a baseline, Monte Carlo simulation was used to introduce four types of data errors (substitution, missing, random, and systematic bias) at three frequency levels (2%, 4%, and 7%). Three commonly used ED operational metrics (arrival to clinician evaluation, disposition decision to exit for admitted patients, and ED length of stay for admitted patients) were calculated and the proportion of ED visits that achieved each performance goal was determined. Results Even small data errors have measurable effects on a clinical organization's ability to accurately determine whether it is meeting its operational performance goals. Systematic substitution errors, increased frequency of errors, and the use of shorter-duration metrics resulted in a lower proportion of ED visits reported as meeting the associated performance objectives. However, the presence of other error types mitigated somewhat the effect of the systematic substitution error. Longer time-duration metrics were found to be less sensitive to data errors than shorter time-duration metrics. Conclusions Infrequent and small-magnitude data errors in EHR timestamps can compromise a clinical organization's ability to determine accurately if it is meeting performance goals. By understanding the types and frequencies of data errors in an organization's EHR, organizational leaders can use data-management best practices to better measure true performance and enhance operational decision-making. PMID:26291051

  9. Using Growth Models to Monitor School Performance: Comparing the Effect of the Metric and the Assessment

    ERIC Educational Resources Information Center

    Goldschmidt, Pete; Choi, Kilchan; Martinez, Felipe; Novak, John

    2010-01-01

    This paper investigates whether inferences about school performance based on longitudinal models are consistent when different assessments and metrics are used as the basis for analysis. Using norm-referenced (NRT) and standards-based (SBT) assessment results from panel data of a large heterogeneous school district, we examine inferences based on…

  10. The effect of climate–carbon cycle feedbacks on emission metrics

    NASA Astrophysics Data System (ADS)

    Sterner, Erik O.; Johansson, Daniel J. A.

    2017-03-01

    The Climate–Carbon cycle Feedback (CCF) affects emission metric values. In the Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change metric values for Global Warming Potentials (GWP) and Global Temperature Potentials (GTP) are reported both with and without CCF for non-CO2 climate forcers, while CCF is always included for CO2. The estimation of CCF for non-CO2 climate forcers in AR5 is based on a linear feedback analysis. This study compares that approach with an explicit approach that uses a temperature dependent carbon cycle model. The key difference in the CCF results for non-CO2 climate forcers is that, with the approach used in AR5, a fraction of the CO2 signal induced by non-CO2 forcers will persist in the atmosphere basically forever, while, with the approach based on an explicit carbon cycle model, the atmospheric CO2 signal induced by non-CO2 forcers eventually vanishes. The differences in metric values between the two model approaches are within ±10% for all well-mixed greenhouse gases when the time horizon is limited to 100 yr or less, for both GWP and GTP. However, for long time horizons, such as 500 yr, metric values are substantially lower with the explicit CCF model than with the linear feedback approach, up to 30% lower for GWP and up to 90% lower for GTP.

  11. Effects of Stream and Elevation Resolution on Riparian Metrics and Restoration Identification

    EPA Science Inventory

    Even though riparian areas attenuate nutrients and sediments from agricultural runoff at the field scale, best management practices and locations for restoring riparian areas should be determined at watershed scales. Riparian metrics (e.g., percent forest within 100m of stream)...

  12. Effective detective quantum efficiency for two mammography systems: Measurement and comparison against established metrics

    SciTech Connect

    Salvagnini, Elena; Bosmans, Hilde; Marshall, Nicholas W.; Struelens, Lara

    2013-10-15

    Purpose: The aim of this paper was to illustrate the value of the new metric effective detective quantum efficiency (eDQE) in relation to more established measures in the optimization process of two digital mammography systems. The following metrics were included for comparison against eDQE: detective quantum efficiency (DQE) of the detector, signal difference to noise ratio (SdNR), and detectability index (d′) calculated using a standard nonprewhitened observer with eye filter.Methods: The two systems investigated were the Siemens MAMMOMAT Inspiration and the Hologic Selenia Dimensions. The presampling modulation transfer function (MTF) required for the eDQE was measured using two geometries: a geometry containing scattered radiation and a low scatter geometry. The eDQE, SdNR, and d′ were measured for poly(methyl methacrylate) (PMMA) thicknesses of 20, 40, 60, and 70 mm, with and without the antiscatter grid and for a selection of clinically relevant target/filter (T/F) combinations. Figures of merit (FOMs) were then formed from SdNR and d′ using the mean glandular dose as the factor to express detriment. Detector DQE was measured at energies covering the range of typical clinically used spectra.Results: The MTF measured in the presence of scattered radiation showed a large drop at low spatial frequency compared to the low scatter method and led to a corresponding reduction in eDQE. The eDQE for the Siemens system at 1 mm{sup −1} ranged between 0.15 and 0.27, depending on T/F and grid setting. For the Hologic system, eDQE at 1 mm{sup −1} varied from 0.15 to 0.32, again depending on T/F and grid setting. The eDQE results for both systems showed that the grid increased the system efficiency for PMMA thicknesses of 40 mm and above but showed only small sensitivity to T/F setting. While results of the SdNR and d′ based FOMs confirmed the eDQE grid position results, they were also more specific in terms of T/F selection. For the Siemens system at 20 mm PMMA

  13. Characterizing Social Media Metrics of Scholarly Papers: The Effect of Document Properties and Collaboration Patterns

    PubMed Central

    Haustein, Stefanie; Costas, Rodrigo; Larivière, Vincent

    2015-01-01

    A number of new metrics based on social media platforms—grouped under the term “altmetrics”—have recently been introduced as potential indicators of research impact. Despite their current popularity, there is a lack of information regarding the determinants of these metrics. Using publication and citation data from 1.3 million papers published in 2012 and covered in Thomson Reuters’ Web of Science as well as social media counts from Altmetric.com, this paper analyses the main patterns of five social media metrics as a function of document characteristics (i.e., discipline, document type, title length, number of pages and references) and collaborative practices and compares them to patterns known for citations. Results show that the presence of papers on social media is low, with 21.5% of papers receiving at least one tweet, 4.7% being shared on Facebook, 1.9% mentioned on blogs, 0.8% found on Google+ and 0.7% discussed in mainstream media. By contrast, 66.8% of papers have received at least one citation. Our findings show that both citations and social media metrics increase with the extent of collaboration and the length of the references list. On the other hand, while editorials and news items are seldom cited, it is these types of document that are the most popular on Twitter. Similarly, while longer papers typically attract more citations, an opposite trend is seen on social media platforms. Finally, contrary to what is observed for citations, it is papers in the Social Sciences and humanities that are the most often found on social media platforms. On the whole, these findings suggest that factors driving social media and citations are different. Therefore, social media metrics cannot actually be seen as alternatives to citations; at most, they may function as complements to other type of indicators. PMID:25780916

  14. Characterizing social media metrics of scholarly papers: the effect of document properties and collaboration patterns.

    PubMed

    Haustein, Stefanie; Costas, Rodrigo; Larivière, Vincent

    2015-01-01

    A number of new metrics based on social media platforms--grouped under the term "altmetrics"--have recently been introduced as potential indicators of research impact. Despite their current popularity, there is a lack of information regarding the determinants of these metrics. Using publication and citation data from 1.3 million papers published in 2012 and covered in Thomson Reuters' Web of Science as well as social media counts from Altmetric.com, this paper analyses the main patterns of five social media metrics as a function of document characteristics (i.e., discipline, document type, title length, number of pages and references) and collaborative practices and compares them to patterns known for citations. Results show that the presence of papers on social media is low, with 21.5% of papers receiving at least one tweet, 4.7% being shared on Facebook, 1.9% mentioned on blogs, 0.8% found on Google+ and 0.7% discussed in mainstream media. By contrast, 66.8% of papers have received at least one citation. Our findings show that both citations and social media metrics increase with the extent of collaboration and the length of the references list. On the other hand, while editorials and news items are seldom cited, it is these types of document that are the most popular on Twitter. Similarly, while longer papers typically attract more citations, an opposite trend is seen on social media platforms. Finally, contrary to what is observed for citations, it is papers in the Social Sciences and humanities that are the most often found on social media platforms. On the whole, these findings suggest that factors driving social media and citations are different. Therefore, social media metrics cannot actually be seen as alternatives to citations; at most, they may function as complements to other type of indicators.

  15. Distinguishing the effects of habitat degradation and pesticide stress on benthic invertebrates using stressor-specific metrics.

    PubMed

    von der Ohe, Peter Carsten; Goedkoop, Willem

    2013-02-01

    Hydromorphological degradation is a well known stressor for running waters, while the effects of elevated levels of pesticides are widely ignored. Hence, distinguishing between the effects of these two stressors is an urgent task for water managers that aim at appropriate remediation measures. We used a large monitoring data set on benthic invertebrates, habitat descriptors, and physico-chemical variables to develop the SPEAR[%](habitat) metric that indicates the effects of in-stream habitat degradation. SPEAR[%](habitat) correlated significantly with the habitat degradation score (HDS; based on substratum and vegetation coverage), while it did not respond to any physico-chemical variables (r(2)=0.20). This relationship improved for streams with low modeled pesticide inputs (r(2)=0.33), and improved even further for a subset of streams dominated by soft-bottom substrata, i.e. for similar stream-types (r(2)=0.65). These relationships were confirmed for an independent dataset that was not used in the derivation of the HDS (r(2)=0.57 and r(2)=0.65, respectively). These findings show that the SPEAR[%](habitat) had a high degree of specificity for the effects of habitat degradation. Conversely, neither the commonly used EPT and ASPT metrics, nor the German Fauna Index or SPEAR[%](pesticides) showed significant relationships with HDS. These metrics instead correlated significantly with the run-off potential (RP), a proxy of pesticide contamination of streams. Similarly, RP was also the most important explanatory variable for SPEAR[%](pesticides), followed by alkalinity and the number of forested upstream stretches (r(2)=0.61). The latter are expected to alleviate pesticide effects, as indicated by higher SPEAR[%](pesticides) values. These findings show that an integrated analysis of the two stressor-specific SPEAR-metrics in combination with the metrics of general ecological degradation can help water managers to distinguish between the effects of habitat degradation and

  16. The International Safeguards Technology Base: How is the Patient Doing? An Exploration of Effective Metrics

    SciTech Connect

    Schanfein, Mark J; Gouveia, Fernando S

    2010-07-01

    The term “Technology Base” is commonly used but what does it mean? Is there a common understanding of the components that comprise a technology base? Does a formal process exist to assess the health of a given technology base? These are important questions the relevance of which is even more pressing given the USDOE/NNSA initiatives to strengthen the safeguards technology base through investments in research & development and human capital development. Accordingly, the authors will establish a high-level framework to define and understand what comprises a technology base. Potential goal-driven metrics to assess the health of a technology base will also be explored, such as linear demographics and resource availability, in the hope that they can be used to better understand and improve the health of the U.S. safeguards technology base. Finally, through the identification of such metrics, the authors will offer suggestions and highlight choices for addressing potential shortfalls.

  17. Exposure: A New Decision Metric for Selecting Effective Sets of Security Upgrades

    DTIC Science & Technology

    2015-01-01

    consequently, several hundred conditional risk estimates. This paper introduces a decision metric, exposure, which allows the analyst to aggregate...associated graphics throughout this paper are drawn from Michael Keleher, Steven Walser, and Samuel Himel, The Common Risk Model for Dams Support System...A Prototype Analyst Tool (Alexandria, VA: Institute for Defense Analyses, IDA Paper P-5220, to be published). Values in the table are rounded

  18. Wave function of the Universe, preferred reference frame effects and metric signature transition

    NASA Astrophysics Data System (ADS)

    Ghaffarnejad, Hossein

    2015-09-01

    Gravitational model of non-minimally coupled Brans Dicke (BD) scalar field 0 with dynamical unit time-like four vector field is used to study flat Robertson Walker (RW) cosmology in the presence of variable cosmological parameter V (ϕ) = Λϕ. Aim of the paper is to seek cosmological models which exhibit metric signature transition. The problem is studied in both classical and quantum cosmological approach with large values of BD parameter ω >> 1. Scale factor of RW metric is obtained as which describes nonsingular inflationary universe in Lorentzian signature sector. Euclidean signature sector of our solution describes a re-collapsing universe and is obtained from analytic continuation of the Lorentzian sector by exchanging . Dynamical vector field together with the BD scalar field are treated as fluid with time dependent barotropic index. They have regular (dark) matter dominance in the Euclidean (Lorentzian) sector. We solved Wheeler De Witt (WD) quantum wave equation of the cosmological system. Assuming a discrete non-zero ADM mass we obtained solutions of the WD equation as simple harmonic quantum Oscillator eigen functionals described by Hermite polynomials. Absolute values of these eigen functionals have nonzero values on the hypersurface in which metric field has signature degeneracy. Our eigen functionals describe nonzero probability of the space time with Lorentzian (Euclidean) signature for . Maximal probability corresponds to the ground state j = 0.

  19. Handbook of aircraft noise metrics

    NASA Technical Reports Server (NTRS)

    Bennett, R. L.; Pearsons, K. S.

    1981-01-01

    Information is presented on 22 noise metrics that are associated with the measurement and prediction of the effects of aircraft noise. Some of the instantaneous frequency weighted sound level measures, such as A-weighted sound level, are used to provide multiple assessment of the aircraft noise level. Other multiple event metrics, such as day-night average sound level, were designed to relate sound levels measured over a period of time to subjective responses in an effort to determine compatible land uses and aid in community planning. The various measures are divided into: (1) instantaneous sound level metrics; (2) duration corrected single event metrics; (3) multiple event metrics; and (4) speech communication metrics. The scope of each measure is examined in terms of its: definition, purpose, background, relationship to other measures, calculation method, example, equipment, references, and standards.

  20. The anxiolytic effects of resistance exercise

    PubMed Central

    Strickland, Justin C.; Smith, Mark A.

    2014-01-01

    Numerous studies have revealed the beneficial effects of regular exercise across a variety of mental health measures. Although a great deal of attention has been paid to the role of aerobic exercise, less is known about the role of resistance exercise (i.e., strength training) in mental health outcomes. Resistance exercise includes a broad group of procedures that evoke repeated muscle action against resistances above those encountered in daily life. A growing body of literature has identified anxiolytic effects of resistance exercise in human populations after both single-bout sessions and long-term training. This research has shown that resistance training at a low-to-moderate intensity (<70% 1 repetition maximum) produces the most reliable and robust decreases in anxiety. Importantly, anxiolytic effects have been observed across a diverse range of populations and dependent measures. These findings provide support for the use of resistance exercise in the clinical management of anxiety. PMID:25071694

  1. Probing the post-newtonian physics of semi-conservative metric theories through secular tidal effects in satellite gradiometry missions

    NASA Astrophysics Data System (ADS)

    Qiang, Li-E.; Xu, Peng

    2016-04-01

    The existence of relativistic secular tidal effects along orbit motions will largely improve the measurement accuracies of relativistic gravitational gradients with orbiting gradiometers. With the continuous advances in technologies related to gradiometry and the improvements in their resolutions, it is feasible for future satellite gradiometry missions to carry out precision relativistic experiments and impose constraints on modern theories of gravity. In this work, we study the theoretical principles of measuring directly the secular post-Newtonian (PN) tidal effects in semi-conservative metric theories with satellite gradiometry missions. The isolations of the related PN parameters in the readouts of an orbiting three-axis gradiometer is discussed.

  2. Prediction of junior faculty success in biomedical research: comparison of metrics and effects of mentoring programs.

    PubMed

    von Bartheld, Christopher S; Houmanfar, Ramona; Candido, Amber

    2015-01-01

    Measuring and predicting the success of junior faculty is of considerable interest to faculty, academic institutions, funding agencies and faculty development and mentoring programs. Various metrics have been proposed to evaluate and predict research success and impact, such as the h-index, and modifications of this index, but they have not been evaluated and validated side-by-side in a rigorous empirical study. Our study provides a retrospective analysis of how well bibliographic metrics and formulas (numbers of total, first- and co-authored papers in the PubMed database, numbers of papers in high-impact journals) would have predicted the success of biomedical investigators (n = 40) affiliated with the University of Nevada, Reno, prior to, and after completion of significant mentoring and research support (through funded Centers of Biomedical Research Excellence, COBREs), or lack thereof (unfunded COBREs), in 2000-2014. The h-index and similar indices had little prognostic value. Publishing as mid- or even first author in only one high-impact journal was poorly correlated with future success. Remarkably, junior investigators with >6 first-author papers within 10 years were significantly (p < 0.0001) more likely (93%) to succeed than those with ≤6 first-author papers (4%), regardless of the journal's impact factor. The benefit of COBRE-support increased the success rate of junior faculty approximately 3-fold, from 15% to 47%. Our work defines a previously neglected set of metrics that predicted the success of junior faculty with high fidelity-thus defining the pool of faculty that will benefit the most from faculty development programs such as COBREs.

  3. The metric system: An introduction

    SciTech Connect

    Lumley, S.M.

    1995-05-01

    On July 13, 1992, Deputy Director Duane Sewell restated the Laboratory`s policy on conversion to the metric system which was established in 1974. Sewell`s memo announced the Laboratory`s intention to continue metric conversion on a reasonable and cost effective basis. Copies of the 1974 and 1992 Administrative Memos are contained in the Appendix. There are three primary reasons behind the Laboratory`s conversion to the metric system. First, Public Law 100-418, passed in 1988, states that by the end of fiscal year 1992 the Federal Government must begin using metric units in grants, procurements, and other business transactions. Second, on July 25, 1991, President George Bush signed Executive Order 12770 which urged Federal agencies to expedite conversion to metric units. Third, the contract between the University of California and the Department of Energy calls for the Laboratory to convert to the metric system. Thus, conversion to the metric system is a legal requirement and a contractual mandate with the University of California. Public Law 100-418 and Executive Order 12770 are discussed in more detail later in this section, but first they examine the reasons behind the nation`s conversion to the metric system. The second part of this report is on applying the metric system.

  4. The effects of immediate achievement and retention of middle school students involved in a metric unit designed to promote the development of estimating skills

    NASA Astrophysics Data System (ADS)

    Jones, Michael L.; Rowsey, Robert E.

    1990-12-01

    Three hundred nintey-seven seventh-grade students were studied to determine the effect on immediate achievement and retention of a unit designed to promote the development of estimating skills involved in metric measurement. The study involved five teachers with a total of 15 average- or advanced-level classes divided into the reference and treatment groups. A five-day metric unit was designed so that both groups received exactly the same instruction in metric length, mass, and capacity with the exception of the treatment group's participation in activities relating to the development of estimation skills. Data collected from the Metric Application Instrument and analyzed with analysis of covariance indicated that students in the experimental group did retain significantly more of their improved metric application skills than the students in the reference group. The analysis of the main effects of race, sex, and ability indicated that white students achieved significantly more than black students and that males achieved significantly more than females. Analysis of significant race/ability and sex/race interactions indicated that (a) white students in the advanced group attained significantly greater achievement in metric application skills than black students of equal status and (b) white males significantly retained their metric applications achievement when compared to black males or black or white females.

  5. Conversion to the Metric System

    ERIC Educational Resources Information Center

    Crunkilton, John C.; Lee, Jasper S.

    1974-01-01

    The authors discuss background information about the metric system and explore the effect of metrication of agriculture in areas such as equipment calibration, chemical measurement, and marketing of agricultural products. Suggestions are given for possible leadership roles and approaches that agricultural education might take in converting to the…

  6. Quality metrics for product defectiveness at KCD

    SciTech Connect

    Grice, J.V.

    1993-07-01

    Metrics are discussed for measuring and tracking product defectiveness at AlliedSignal Inc., Kansas City Division (KCD). Three new metrics, the metric (percent defective) that preceded the new metrics, and several alternatives are described. The new metrics, Percent Parts Accepted, Percent Parts Accepted Trouble Free, and Defects Per Million Observations, (denoted by PPA, PATF, and DPMO, respectively) were implemented for KCD-manufactured product and purchased material in November 1992. These metrics replace the percent defective metric that had been used for several years. The PPA and PATF metrics primarily measure quality performance while DPMO measures the effects of continuous improvement activities. The new metrics measure product quality in terms of product defectiveness observed only during the inspection process. The metrics were originally developed for purchased product and were adapted to manufactured product to provide a consistent set of metrics plant- wide. The new metrics provide a meaningful tool to measure the quantity of product defectiveness in terms of the customer`s requirements and expectations for quality. Many valid metrics are available and all will have deficiencies. These three metrics are among the least sensitive to problems and are easily understood. They will serve as good management tools for KCD in the foreseeable future until new flexible data systems and reporting procedures can be implemented that can provide more detailed and accurate metric computations.

  7. Clinical metric and medication persistency effects: evidence from a Medicaid care management program.

    PubMed

    Berg, Gregory D; Leary, Fredric; Medina, Wendie; Donnelly, Shawn; Warnick, Kathleen

    2015-02-01

    The objective was to estimate clinical metric and medication persistency impacts of a care management program. The data sources were Medicaid administrative claims for a sample population of 32,334 noninstitutionalized Medicaid-only aged, blind, or disabled patients with diagnosed conditions of asthma, coronary artery disease, chronic obstructive pulmonary disease, diabetes, or heart failure between 2005 and 2009. Multivariate regression analysis was used to test the hypothesis that exposure to a care management intervention increased the likelihood of having the appropriate medication or procedures performed, as well as increased medication persistency. Statistically significant clinical metric improvements occurred in each of the 5 conditions studied. Increased medication persistency was found for beta-blocker medication for members with coronary artery disease, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker and diuretic medications for members with heart failure, bronchodilator and corticosteroid medications for members with chronic obstructive pulmonary disease, and aspirin/antiplatelet medications for members with diabetes. This study demonstrates that a care management program increases the likelihood of having an appropriate medication dispensed and/or an appropriate clinical test performed, as well as increased likelihood of medication persistency, in people with chronic conditions.

  8. NASA metrication activities

    NASA Technical Reports Server (NTRS)

    Vlannes, P. N.

    1978-01-01

    NASA's organization and policy for metrification, history from 1964, NASA participation in Federal agency activities, interaction with nongovernmental metrication organizations, and the proposed metrication assessment study are reviewed.

  9. Software Quality Assurance Metrics

    NASA Technical Reports Server (NTRS)

    McRae, Kalindra A.

    2004-01-01

    Software Quality Assurance (SQA) is a planned and systematic set of activities that ensures conformance of software life cycle processes and products conform to requirements, standards and procedures. In software development, software quality means meeting requirements and a degree of excellence and refinement of a project or product. Software Quality is a set of attributes of a software product by which its quality is described and evaluated. The set of attributes includes functionality, reliability, usability, efficiency, maintainability, and portability. Software Metrics help us understand the technical process that is used to develop a product. The process is measured to improve it and the product is measured to increase quality throughout the life cycle of software. Software Metrics are measurements of the quality of software. Software is measured to indicate the quality of the product, to assess the productivity of the people who produce the product, to assess the benefits derived from new software engineering methods and tools, to form a baseline for estimation, and to help justify requests for new tools or additional training. Any part of the software development can be measured. If Software Metrics are implemented in software development, it can save time, money, and allow the organization to identify the caused of defects which have the greatest effect on software development. The summer of 2004, I worked with Cynthia Calhoun and Frank Robinson in the Software Assurance/Risk Management department. My task was to research and collect, compile, and analyze SQA Metrics that have been used in other projects that are not currently being used by the SA team and report them to the Software Assurance team to see if any metrics can be implemented in their software assurance life cycle process.

  10. A Dynamic Testing Complexity Metric

    NASA Technical Reports Server (NTRS)

    Voas, Jeffrey

    1991-01-01

    This paper introduces a dynamic metric that is based on the estimated ability of a program to withstand the effects of injected "semantic mutants" during execution by computing the same function as if the semantic mutants had not been injected. Semantic mutants include: (1) syntactic mutants injected into an executing program and (2) randomly selected values injected into an executing program's internal states. The metric is a function of a program, the method used for injecting these two types of mutants, and the program's input distribution; this metric is found through dynamic executions of the program. A program's ability to withstand the effects of injected semantic mutants by computing the same function when executed is then used as a tool for predicting the difficulty that will be incurred during random testing to reveal the existence of faults, i.e., the metric suggests the likelihood that a program will expose the existence of faults during random testing assuming faults were to exist. If the metric is applied to a module rather than to a program, the metric can be used to guide the allocation of testing resources among a program's modules. In this manner the metric acts as a white-box testing tool for determining where to concentrate testing resources. Index Terms: Revealing ability, random testing, input distribution, program, fault, failure.

  11. Effectiveness of vegetation-based biodiversity offset metrics as surrogates for ants.

    PubMed

    Hanford, Jayne K; Crowther, Mathew S; Hochuli, Dieter F

    2017-02-01

    Biodiversity offset schemes are globally popular policy tools for balancing the competing demands of conservation and development. Trading currencies for losses and gains in biodiversity value at development and credit sites are usually based on several vegetation attributes combined to yield a simple score (multimetric), but the score is rarely validated prior to implementation. Inaccurate biodiversity trading currencies are likely to accelerate global biodiversity loss through unrepresentative trades of losses and gains. We tested a model vegetation multimetric (i.e., vegetation structural and compositional attributes) typical of offset trading currencies to determine whether it represented measurable components of compositional and functional biodiversity. Study sites were located in remnant patches of a critically endangered ecological community in western Sydney, Australia, an area representative of global conflicts between conservation and expanding urban development. We sampled ant fauna composition with pitfall traps and enumerated removal by ants of native plant seeds from artificial seed containers (seed depots). Ants are an excellent model taxon because they are strongly associated with habitat complexity, respond rapidly to environmental change, and are functionally important at many trophic levels. The vegetation multimetric did not predict differences in ant community composition or seed removal, despite underlying assumptions that biodiversity trading currencies used in offset schemes represent all components of a site's biodiversity value. This suggests that vegetation multimetrics are inadequate surrogates for total biodiversity value. These findings highlight the urgent need to refine existing offsetting multimetrics to ensure they meet underlying assumptions of surrogacy. Despite the best intentions, offset schemes will never achieve their goal of no net loss of biodiversity values if trades are based on metrics unrepresentative of total

  12. Effect of fensuccinal on experimental insulin resistance.

    PubMed

    Gorbenko, N I; Poltorak, V V; Gladkikh, A I; Ivanova, O V

    2000-07-01

    The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably due to its antioxidant properties.

  13. Aquatic Acoustic Metrics Interface

    SciTech Connect

    2012-12-18

    Fishes and marine mammals may suffer a range of potential effects from exposure to intense underwater sound generated by anthropogenic activities such as pile driving, shipping, sonars, and underwater blasting. Several underwater sound recording (USR) devices have been built to acquire samples of the underwater sound generated by anthropogenic activities. Software becomes indispensable for processing and analyzing the audio files recorded by these USRs. The new Aquatic Acoustic Metrics Interface Utility Software (AAMI) is specifically designed for analysis of underwater sound recordings to provide data in metrics that facilitate evaluation of the potential impacts of the sound on aquatic animals. In addition to the basic functions, such as loading and editing audio files recorded by USRs and batch processing of sound files, the software utilizes recording system calibration data to compute important parameters in physical units. The software also facilitates comparison of the noise sound sample metrics with biological measures such as audiograms of the sensitivity of aquatic animals to the sound, integrating various components into a single analytical frame.

  14. NASA metric transition plan

    NASA Technical Reports Server (NTRS)

    1992-01-01

    NASA science publications have used the metric system of measurement since 1970. Although NASA has maintained a metric use policy since 1979, practical constraints have restricted actual use of metric units. In 1988, an amendment to the Metric Conversion Act of 1975 required the Federal Government to adopt the metric system except where impractical. In response to Public Law 100-418 and Executive Order 12770, NASA revised its metric use policy and developed this Metric Transition Plan. NASA's goal is to use the metric system for program development and functional support activities to the greatest practical extent by the end of 1995. The introduction of the metric system into new flight programs will determine the pace of the metric transition. Transition of institutional capabilities and support functions will be phased to enable use of the metric system in flight program development and operations. Externally oriented elements of this plan will introduce and actively support use of the metric system in education, public information, and small business programs. The plan also establishes a procedure for evaluating and approving waivers and exceptions to the required use of the metric system for new programs. Coordination with other Federal agencies and departments (through the Interagency Council on Metric Policy) and industry (directly and through professional societies and interest groups) will identify sources of external support and minimize duplication of effort.

  15. More Than Numbers: Effects of Social Media Virality Metrics on Intention to Help Unknown Others in the Context of Bone Marrow Donation.

    PubMed

    Lee-Won, Roselyn J; Abo, Melissa M; Na, Kilhoe; White, Tiffany N

    2016-06-01

    A bone marrow transplant is often the only key to recovery and survival for patients suffering from blood cancers. Social media platforms have allowed nonprofit organizations as well as family members and friends of patients in need of a matching donor to make their solicitation messages go viral and reach out to the broadest possible audience to increase the likelihood of finding a matching donor. Noting that social media audiences are exposed not only to the content of a social media message but also to the metrics representing the virality of the message (i.e., how many times the content has been shared), we conducted an online experiment to investigate the effects of virality metrics on perceived social norms and behavioral intention to join a bone marrow registry. In doing so, we considered the potential moderating role of perceived threat posed by blood cancers. The experiment was conducted with 152 participants who met the general eligibility guidelines set by the National Marrow Donor Program (NMDP). The results of the experiment showed that exposure to high virality metrics led to greater perceived injunctive norms. The results also revealed that the effect of virality metrics on perceived injunctive norms was significant among those perceiving low levels of blood cancer threat. Furthermore, the results demonstrated that high virality metrics led to greater intention to join a bone marrow registry through perceived injunctive norms only when perceived threat of blood cancers was low. Theoretical and practical implications of these findings are discussed.

  16. Multi-site Study of Diffusion Metric Variability: Characterizing the Effects of Site, Vendor, Field Strength, and Echo Time using the Histogram Distance

    PubMed Central

    Helmer, K. G.; Chou, M-C.; Preciado, R. I.; Gimi, B.; Rollins, N. K.; Song, A.; Turner, J.; Mori, S.

    2016-01-01

    MRI-based multi-site trials now routinely include some form of diffusion-weighted imaging (DWI) in their protocol. These studies can include data originating from scanners built by different vendors, each with their own set of unique protocol restrictions, including restrictions on the number of available gradient directions, whether an externally-generated list of gradient directions can be used, and restrictions on the echo time (TE). One challenge of multi-site studies is to create a common imaging protocol that will result in a reliable and accurate set of diffusion metrics. The present study describes the effect of site, scanner vendor, field strength, and TE on two common metrics: the first moment of the diffusion tensor field (mean diffusivity, MD), and the fractional anisotropy (FA). We have shown in earlier work that ROI metrics and the mean of MD and FA histograms are not sufficiently sensitive for use in site characterization. Here we use the distance between whole brain histograms of FA and MD to investigate within- and between-site effects. We concluded that the variability of DTI metrics due to site, vendor, field strength, and echo time could influence the results in multi-center trials and that histogram distance is sensitive metrics for each of these variables. PMID:27350723

  17. FY 2011 4th Quarter Metric: Estimate of Future Aerosol Direct and Indirect Effects

    SciTech Connect

    Koch, D

    2011-09-21

    The global and annual mean aerosol direct and indirect effects, relative to 1850 conditions, estimated from CESM simulations are 0.02 W m-2 and -0.39 W m-2, respectively, for emissions in year 2100 under the IPCC RCP8.5 scenario. The indirect effect is much smaller than that for 2000 emissions because of much smaller SO2 emissions in 2100; the direct effects are small due to compensation between warming by black carbon and cooling by sulfate.

  18. How Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?

    PubMed Central

    Kay, Katherine

    2015-01-01

    Artemisinin-based combination therapies (ACTs) are currently the first-line drugs for treating uncomplicated falciparum malaria, the most deadly of the human malarias. Malaria parasite clearance rates estimated from patients' blood following ACT treatment have been widely adopted as a measure of drug effectiveness and as surveillance tools for detecting the presence of potential artemisinin resistance. This metric has not been investigated in detail, nor have its properties or potential shortcomings been identified. Herein, the pharmacology of drug treatment, parasite biology, and human immunity are combined to investigate the dynamics of parasite clearance following ACT. This approach parsimoniously recovers the principal clinical features and dynamics of clearance. Human immunity is the primary determinant of clearance rates, unless or until artemisinin killing has fallen to near-ineffective levels. Clearance rates are therefore highly insensitive metrics for surveillance that may lead to overconfidence, as even quite substantial reductions in drug sensitivity may not be detected as lower clearance rates. Equally serious is the use of clearance rates to quantify the impact of ACT regimen changes, as this strategy will plausibly miss even very substantial increases in drug effectiveness. In particular, the malaria community may be missing the opportunity to dramatically increase ACT effectiveness through regimen changes, particularly through a switch to twice-daily regimens and/or increases in artemisinin dosing levels. The malaria community therefore appears overreliant on a single metric of drug effectiveness, the parasite clearance rate, that has significant and serious shortcomings. PMID:26239987

  19. Effecting Change in a Resistant Organization.

    ERIC Educational Resources Information Center

    Caldwell, Patricia F.; Gould, Edward

    In an effort to overcome organizational resistance to change, Victor Valley College, in Victorville, California, has utilized a seven-part strategy to enable leaders to empower others and effect change. Step 1 requires the development of a visionary plan, so that changes have a meaningful context. Step 2 calls for an assessment of the campus…

  20. Effective flow resistivity of highway pavements.

    PubMed

    Rochat, Judith L; Read, David R

    2013-12-01

    In the case of highway traffic noise, propagating sound is influenced by the ground over which it travels, whether it is the pavement itself or the ground between the highway and nearby communities. Properly accounting for ground type in modeling can increase accuracy in noise impact determinations and noise abatement design. Pavement-specific effective flow resistivity values are being investigated for inclusion in the Federal Highway Administration Traffic Noise Model, which uses these values in the sound propagation algorithms and currently applies a single effective flow resistivity value to all pavement. Pavement-specific effective flow resistivity values were obtained by applying a modified version of the American National Standards Institute S1.18 standard. The data analysis process was tailored to allow for increased sensitivity and extraction of effective flow resistivity values for a broad range of pavements (sound absorptive to reflective). For porous pavements (sound absorptive), it was determined that examination of the measured data can reveal influence from an underlying structure. Use of such techniques can aid in the design of quieter pavements.

  1. Moving to Metric.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh.

    This booklet, designed to help the consumer prepare for the change to the metric system, discusses the following related topics: simplicity and universality of the metric system, weather, shopping, textiles, cooking, and driving. (MP)

  2. Substrate effect in chemically amplified resist

    NASA Astrophysics Data System (ADS)

    Mori, Shigeyasu; Watanabe, Takeo; Adachi, Kouichirou; Fukushima, Takashi; Uda, Keichiro; Sato, Yuichi

    1996-06-01

    SiN substrate effect in chemically amplified (CA) resist has been investigated by surface analysis and evaluating the pattern profile of CA negative tone resist. Fine profile can be replicated on SiN substrate treated with oxygen plasma optimized condition. Undercut profile can be affected by adsorbed materials on SiN substrate from thermal desorption spectroscopy (TDS) analysis results. From the results of electron spectroscopy for chemical analysis (ESCA), it is found that Si-N bonding is replaced to Si-O bonding while SiN substrate is treated with oxygen plasma. Relations between footing length and oxygen plasma treatment condition suggest that undercut profile due to the concentration of nitrogen on the surface of SiN substrate. At the interface between the SiN substrate and the CA resist, the SiN substrate works as base existing water, and quenches photo-generated-acids. The mechanism of substrate effect of SiN is clarified. Reducing the SiN-substrate effect by treating the surface with oxygen plasma, fine resist pattern without undercut and footing is formed on SiN substrate.

  3. Metrics in Career Education.

    ERIC Educational Resources Information Center

    Lindbeck, John R.

    The United States is rapidly becoming a metric nation. Industry, education, business, and government are all studying the issue of metrication to learn how they can prepare for it. The book is designed to help teachers and students in career education programs learn something about metrics. Presented in an easily understood manner, the textbook's…

  4. Metrication for the Manager.

    ERIC Educational Resources Information Center

    Benedict, John T.

    The scope of this book covers metrication management. It was created to fill the middle management need for condensed, authoritative information about the metrication process and was conceived as a working tool and a prime reference source. Written from a management point of view, it touches on virtually all aspects of metrication and highlights…

  5. Phylogenetic metrics of community similarity.

    PubMed

    Ives, Anthony R; Helmus, Matthew R

    2010-11-01

    We derive a new metric of community similarity that takes into account the phylogenetic relatedness among species. This metric, phylogenetic community dissimilarity (PCD), can be partitioned into two components, a nonphylogenetic component that reflects shared species between communities (analogous to Sørensen' s similarity metric) and a phylogenetic component that reflects the evolutionary relationships among nonshared species. Therefore, even if a species is not shared between two communities, it will increase the similarity of the two communities if it is phylogenetically related to species in the other community. We illustrate PCD with data on fish and aquatic macrophyte communities from 59 temperate lakes. Dissimilarity between fish communities associated with environmental differences between lakes often has a phylogenetic component, whereas this is not the case for macrophyte communities. With simulations, we then compare PCD with two other metrics of phylogenetic community similarity, II(ST) and UniFrac. Of the three metrics, PCD was best at identifying environmental drivers of community dissimilarity, showing lower variability and greater statistical power. Thus, PCD is a statistically powerful metric that separates the effects of environmental drivers on compositional versus phylogenetic components of community structure.

  6. Using Social Network Metrics to Assess the Effectiveness of Broad Based Admission Practices

    ERIC Educational Resources Information Center

    Dawson, Shane; Macfadyen, Leah; Lockyer, Lori; Mazzochi-Jones, David

    2011-01-01

    Notions of what it is to be knowledgeable and skilled in one's profession have evolved in recent decades. For instance, medical practitioners are expected to think critically and creatively, communicate effectively, and to be a professional and community leader. While these attributes have always been well regarded, it is only relatively recently…

  7. Chronic effects of temperature on mortality in the Southeastern USA using satellite-based exposure metrics

    PubMed Central

    Shi, Liuhua; Liu, Pengfei; Wang, Yan; Zanobetti, Antonella; Kosheleva, Anna; Koutrakis, Petros; Schwartz, Joel

    2016-01-01

    Climate change may affect human health, particularly for elderly individuals who are vulnerable to temperature changes. While many studies have investigated the acute effects of heat, only a few have dealt with the chronic ones. We have examined the effects of seasonal temperatures on survival of the elderly in the Southeastern USA, where a large fraction of subpopulation resides. We found that both seasonal mean temperature and its standard deviation (SD) affected long-term survival among the 13 million Medicare beneficiaries (aged 65+) in this region during 2000–2013. A 1 °C increase in summer mean temperature corresponded to an increase of 2.5% in death rate. Whereas, 1 °C increase in winter mean temperature was associated with a decrease of 1.5%. Increases in seasonal temperature SD also influence mortality. We decomposed seasonal mean temperature and its temperature SD into long-term geographic contrasts between ZIP codes and annual anomalies within ZIP code. Effect modifications by different subgroups were also examined to find out whether certain individuals are more vulnerable. Our findings will be critical to future efforts assessing health risks related to the future climate change. PMID:27436237

  8. Chronic effects of temperature on mortality in the Southeastern USA using satellite-based exposure metrics

    NASA Astrophysics Data System (ADS)

    Shi, Liuhua; Liu, Pengfei; Wang, Yan; Zanobetti, Antonella; Kosheleva, Anna; Koutrakis, Petros; Schwartz, Joel

    2016-07-01

    Climate change may affect human health, particularly for elderly individuals who are vulnerable to temperature changes. While many studies have investigated the acute effects of heat, only a few have dealt with the chronic ones. We have examined the effects of seasonal temperatures on survival of the elderly in the Southeastern USA, where a large fraction of subpopulation resides. We found that both seasonal mean temperature and its standard deviation (SD) affected long-term survival among the 13 million Medicare beneficiaries (aged 65+) in this region during 2000–2013. A 1 °C increase in summer mean temperature corresponded to an increase of 2.5% in death rate. Whereas, 1 °C increase in winter mean temperature was associated with a decrease of 1.5%. Increases in seasonal temperature SD also influence mortality. We decomposed seasonal mean temperature and its temperature SD into long-term geographic contrasts between ZIP codes and annual anomalies within ZIP code. Effect modifications by different subgroups were also examined to find out whether certain individuals are more vulnerable. Our findings will be critical to future efforts assessing health risks related to the future climate change.

  9. Assessing treatment effects in clinical trials with the discan metric of the Sheehan Disability Scale.

    PubMed

    Sheehan, Kathy Harnett; Sheehan, David V

    2008-03-01

    The Sheehan Disability Scale (SDS) is a patient-rated, discretized analog measure of functional disability in work, social, and family life. Its increasing use in clinical trials in psychiatry suggests a need to assess its responsiveness and interpretability. In this paper we identify and review studies in which the SDS was used as a treatment outcome measure. Our objectives are (i) to evaluate the sensitivity of the SDS to treatment effects and (ii) to examine potential thresholds or cutoff scores for remission and response. Studies for the review were retrieved from the National Library of Medicine's PubMed database (1966 to 21 March 2007) and other sources. All studies had to use the SDS, be double-blind, controlled or large open-label trials in English. Studies assessing nonpharmacological treatments, long-term trials (>12 weeks), small n trials (less than 20 patients per treatment arm) and trials for conditions other than one of the anxiety disorders, depression, or premenstrual dysphoric disorder were excluded. Extracted data included the diagnostic target of treatment, n, study design, and method of analysis. Initial, endpoint and/or mean change scores were extracted from tables, text, or extrapolated from figures. In all, 37 studies meeting the inclusion criteria were retrieved and reviewed. All of the studies treated the SDS as a numeric scale and analyzed mean change or endpoint differences with parametric statistics. Three provided additional outcome data using nonparametric response or remission criteria. Overall, the SDS performed well in discriminating between active and inactive treatments. The results indicate that the SDS is sensitive to treatment effects. To establish reliable and valid cutoff scores for remission and response, there is a need to supplement parametric analyses using mean change and endpoint differences with nonparametric analyses showing the percentage meeting specified response and remission criteria. In addition, the percentages

  10. Multiple metrics of diversity have different effects on temperate forest functioning over succession.

    PubMed

    Yuan, Zuoqiang; Wang, Shaopeng; Gazol, Antonio; Mellard, Jarad; Lin, Fei; Ye, Ji; Hao, Zhanqing; Wang, Xugao; Loreau, Michel

    2016-12-01

    Biodiversity can be measured by taxonomic, phylogenetic, and functional diversity. How ecosystem functioning depends on these measures of diversity can vary from site to site and depends on successional stage. Here, we measured taxonomic, phylogenetic, and functional diversity, and examined their relationship with biomass in two successional stages of the broad-leaved Korean pine forest in northeastern China. Functional diversity was calculated from six plant traits, and aboveground biomass (AGB) and coarse woody productivity (CWP) were estimated using data from three forest censuses (10 years) in two large fully mapped forest plots (25 and 5 ha). 11 of the 12 regressions between biomass variables (AGB and CWP) and indices of diversity showed significant positive relationships, especially those with phylogenetic diversity. The mean tree diversity-biomass regressions increased from 0.11 in secondary forest to 0.31 in old-growth forest, implying a stronger biodiversity effect in more mature forest. Multi-model selection results showed that models including species richness, phylogenetic diversity, and single functional traits explained more variation in forest biomass than other candidate models. The models with a single functional trait, i.e., leaf area in secondary forest and wood density in mature forest, provided better explanations for forest biomass than models that combined all six functional traits. This finding may reflect different strategies in growth and resource acquisition in secondary and old-growth forests.

  11. Using Fish Population Metrics to Compare the Effects of Artificial Reef Density

    PubMed Central

    2015-01-01

    Artificial reefs continue to be added as habitat throughout the world, yet questions remain about how reef design affects fish diversity and abundance. In the present study, the effects of reef density were assessed for fish communities and sizes of economically valuable Lutjanus campechanus 13 km off Port Mansfield, Texas, at a reef composed of more than 4000 concrete culverts. The study spanned from May to June in 2013 and 2014, and sites sampled included natural reefs, bare areas, and varying culvert patch density categories, ranging from 1–190 culverts. Abundances of adults and species evenness of juvenile populations differed between the years. Fish communities did not significantly differ among density categories; however, highest species richness and total abundances were observed at intermediate culvert densities and at natural reefs. Whereas the abundance of L. campechanus did not differ among density categories, mean total lengths of L. campechanus were greatest at the lower density. Our findings suggest that reefs should be deployed with intermediate patch density of 71–120 culverts in a 30-m radius to yield the highest fish abundances. PMID:26422472

  12. Multi-site study of diffusion metric variability: effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses

    NASA Astrophysics Data System (ADS)

    Helmer, K. G.; Chou, M.-C.; Preciado, R. I.; Gimi, B.; Rollins, N. K.; Song, A.; Turner, J.; Mori, S.

    2016-03-01

    It is now common for magnetic-resonance-imaging (MRI) based multi-site trials to include diffusion-weighted imaging (DWI) as part of the protocol. It is also common for these sites to possess MR scanners of different manufacturers, different software and hardware, and different software licenses. These differences mean that scanners may not be able to acquire data with the same number of gradient amplitude values and number of available gradient directions. Variability can also occur in achievable b-values and minimum echo times. The challenge of a multi-site study then, is to create a common protocol by understanding and then minimizing the effects of scanner variability and identifying reliable and accurate diffusion metrics. This study describes the effect of site, scanner vendor, field strength, and TE on two diffusion metrics: the first moment of the diffusion tensor field (mean diffusivity, MD), and the fractional anisotropy (FA) using two common analyses (region-of-interest and mean-bin value of whole brain histograms). The goal of the study was to identify sources of variability in diffusion-sensitized imaging and their influence on commonly reported metrics. The results demonstrate that the site, vendor, field strength, and echo time all contribute to variability in FA and MD, though to different extent. We conclude that characterization of the variability of DTI metrics due to site, vendor, field strength, and echo time is a worthwhile step in the construction of multi-center trials.

  13. Multi-site study of diffusion metric variability: effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses

    PubMed Central

    Helmer, K. G.; Chou, M-C.; Preciado, R. I.; Gimi, B.; Rollins, N. K.; Song, A.; Turner, J.; Mori, S.

    2016-01-01

    It is now common for magnetic-resonance-imaging (MRI) based multi-site trials to include diffusion-weighted imaging (DWI) as part of the protocol. It is also common for these sites to possess MR scanners of different manufacturers, different software and hardware, and different software licenses. These differences mean that scanners may not be able to acquire data with the same number of gradient amplitude values and number of available gradient directions. Variability can also occur in achievable b-values and minimum echo times. The challenge of a multi-site study then, is to create a common protocol by understanding and then minimizing the effects of scanner variability and identifying reliable and accurate diffusion metrics. This study describes the effect of site, scanner vendor, field strength, and TE on two diffusion metrics: the first moment of the diffusion tensor field (mean diffusivity, MD), and the fractional anisotropy (FA) using two common analyses (region-of-interest and mean-bin value of whole brain histograms). The goal of the study was to identify sources of variability in diffusion-sensitized imaging and their influence on commonly reported metrics. The results demonstrate that the site, vendor, field strength, and echo time all contribute to variability in FA and MD, though to different extent. We conclude that characterization of the variability of DTI metrics due to site, vendor, field strength, and echo time is a worthwhile step in the construction of multi-center trials. PMID:27330240

  14. Menopause: highlighting the effects of resistance training.

    PubMed

    Leite, R D; Prestes, J; Pereira, G B; Shiguemoto, G E; Perez, S E A

    2010-11-01

    The increase in lifespan and in the proportion of elderly women has increased the focus on menopause induced physiological alterations. These modifications are associated with the elevated risk of several pathologies such as cardiovascular disease, diabetes, obesity, hypertension, dyslipidemia, non-alcoholic fat liver disease, among others. Because of estrogen levels decline, many tissue and organs (muscular, bone, adipose tissue and liver) are affected. Additionally, body composition suffers important modifications. In this sense, there is a growing body of concern in understanding the physiological mechanisms involved and establishing strategies to prevent and reverse the effects of menopause. The hormone reposition therapy, diet and physical exercise have been recommended. Among the diverse exercise modalities, resistance training is not commonly used as a therapeutic intervention in the treatment of menopause. Thus, the aim of this review was to analyze the physiological alterations on several organs and systems induced by menopause and ovariectomy (experimental model to reproduce menopause), as well as, to study the effects of resistance training in preventing and reverting these modifications. In conclusion, resistance training promotes beneficial effects on several organs and systems, mainly, on muscular, bone and adipose tissue, allowing for a better quality of life in this population.

  15. Algebraic mesh quality metrics

    SciTech Connect

    KNUPP,PATRICK

    2000-04-24

    Quality metrics for structured and unstructured mesh generation are placed within an algebraic framework to form a mathematical theory of mesh quality metrics. The theory, based on the Jacobian and related matrices, provides a means of constructing, classifying, and evaluating mesh quality metrics. The Jacobian matrix is factored into geometrically meaningful parts. A nodally-invariant Jacobian matrix can be defined for simplicial elements using a weight matrix derived from the Jacobian matrix of an ideal reference element. Scale and orientation-invariant algebraic mesh quality metrics are defined. the singular value decomposition is used to study relationships between metrics. Equivalence of the element condition number and mean ratio metrics is proved. Condition number is shown to measure the distance of an element to the set of degenerate elements. Algebraic measures for skew, length ratio, shape, volume, and orientation are defined abstractly, with specific examples given. Combined metrics for shape and volume, shape-volume-orientation are algebraically defined and examples of such metrics are given. Algebraic mesh quality metrics are extended to non-simplical elements. A series of numerical tests verify the theoretical properties of the metrics defined.

  16. A neural net-based approach to software metrics

    NASA Technical Reports Server (NTRS)

    Boetticher, G.; Srinivas, Kankanahalli; Eichmann, David A.

    1992-01-01

    Software metrics provide an effective method for characterizing software. Metrics have traditionally been composed through the definition of an equation. This approach is limited by the fact that all the interrelationships among all the parameters be fully understood. This paper explores an alternative, neural network approach to modeling metrics. Experiments performed on two widely accepted metrics, McCabe and Halstead, indicate that the approach is sound, thus serving as the groundwork for further exploration into the analysis and design of software metrics.

  17. Effect of nonsymmetrical flow resistance upon orifice impedance resistance

    NASA Technical Reports Server (NTRS)

    Posey, J. W.; Compton, K. J.

    1974-01-01

    A nonreactive orifice in an infinite baffle is analyzed. The pressure difference delta across the orifice varies sinusoidally with amplitude 1.0 and average value -P. The orifice resistance, delta p is discontinuous at zero velocity and exhibits the constant values R sub + and R sub - for u 0 and u 0, respectively. The resultant velocity has power in all harmonics of the excitation frequency. A quasi-linear resistance is defined and found to be relatively insensitive to the presence or absence of a resonant backing cavity; however, it does vary from 1.33 R sub + to 0.67 R sub + for a resistance ratio R sub +/R sub - between 0.5 and 2.0.

  18. A Sensor-Independent Gust Hazard Metric

    NASA Technical Reports Server (NTRS)

    Stewart, Eric C.

    2001-01-01

    A procedure for calculating an intuitive hazard metric for gust effects on airplanes is described. The hazard metric is for use by pilots and is intended to replace subjective pilot reports (PIREPs) of the turbulence level. The hazard metric is composed of three numbers: the first describes the average airplane response to the turbulence, the second describes the positive peak airplane response to the gusts, and the third describes the negative peak airplane response to the gusts. The hazard metric is derived from any time history of vertical gust measurements and is thus independent of the sensor making the gust measurements. The metric is demonstrated for one simulated airplane encountering different types of gusts including those derived from flight data recorder measurements of actual accidents. The simulated airplane responses to the gusts compare favorably with the hazard metric.

  19. Independent Metrics for Protein Backbone and Side-Chain Flexibility: Time Scales and Effects of Ligand Binding.

    PubMed

    Fuchs, Julian E; Waldner, Birgit J; Huber, Roland G; von Grafenstein, Susanne; Kramer, Christian; Liedl, Klaus R

    2015-03-10

    Conformational dynamics are central for understanding biomolecular structure and function, since biological macromolecules are inherently flexible at room temperature and in solution. Computational methods are nowadays capable of providing valuable information on the conformational ensembles of biomolecules. However, analysis tools and intuitive metrics that capture dynamic information from in silico generated structural ensembles are limited. In standard work-flows, flexibility in a conformational ensemble is represented through residue-wise root-mean-square fluctuations or B-factors following a global alignment. Consequently, these approaches relying on global alignments discard valuable information on local dynamics. Results inherently depend on global flexibility, residue size, and connectivity. In this study we present a novel approach for capturing positional fluctuations based on multiple local alignments instead of one single global alignment. The method captures local dynamics within a structural ensemble independent of residue type by splitting individual local and global degrees of freedom of protein backbone and side-chains. Dependence on residue type and size in the side-chains is removed via normalization with the B-factors of the isolated residue. As a test case, we demonstrate its application to a molecular dynamics simulation of bovine pancreatic trypsin inhibitor (BPTI) on the millisecond time scale. This allows for illustrating different time scales of backbone and side-chain flexibility. Additionally, we demonstrate the effects of ligand binding on side-chain flexibility of three serine proteases. We expect our new methodology for quantifying local flexibility to be helpful in unraveling local changes in biomolecular dynamics.

  20. Leading Gainful Employment Metric Reporting

    ERIC Educational Resources Information Center

    Powers, Kristina; MacPherson, Derek

    2016-01-01

    This chapter will address the importance of intercampus involvement in reporting of gainful employment student-level data that will be used in the calculation of gainful employment metrics by the U.S. Department of Education. The authors will discuss why building relationships within the institution is critical for effective gainful employment…

  1. Powerful Metrics: Strategic and Transformative

    ERIC Educational Resources Information Center

    Butterfield, Barbara

    2006-01-01

    To be a valuable partner at the strategic level, human resources can and should contribute to both institutional effectiveness measurement and workforce metrics. In this article, the author examines how to link HR initiatives with key institutional strategies, clarifies essential HR responsibilities for workforce results, explores return on human…

  2. Assessment of a prognostic model, PSA metrics and toxicities in metastatic castrate resistant prostate cancer using data from Project Data Sphere (PDS)

    PubMed Central

    Hamilton, Robert J.; Abdallah, Kald; Pintilie, Melania; Joshua, Anthony M.

    2017-01-01

    Background Prognostic models in metastatic castrate resistant prostate cancer (mCRPC) may have clinical utility. Using data from PDS, we aimed to 1) validate a contemporary prognostic model (Templeton et al., 2014) 2) evaluate prognostic impact of concomitant medications and PSA decrease 3) evaluate factors associated with docetaxel toxicity. Methods We accessed data on 2,449 mCRPC patients in PDS. The existing model was validated with a continuous risk score, time-dependent receiver operating characteristic (ROC) curves, and corresponding time-dependent Area under the Curve (tAUC). The prognostic effects of concomitant medications and PSA response were assessed by Cox proportional hazards models. One year tAUC was calculated for multivariable prognostic model optimized to our data. Conditional logistic regression models were used to assess associations with grade 3/4 adverse events (G3/4 AE) at baseline and after cycle 1 of treatment. Results Despite limitations of the PDS data set, the existing model was validated; one year AUC, was 0.68 (95% CI 95% CI, .66 to .71) to 0.78 (95%CI, .74 to .81) depending on the subset of datasets used. A new model was constructed with an AUC of .74 (.72 to .77). Concomitant medications low molecular weight heparin and warfarin were associated with poorer survival, Metformin and Cox2 inhibitors were associated with better outcome. PSA response was associated with survival, the effect of which was greatest early in follow-up. Age was associated with baseline risk of G3/4 AE. The odds of experiencing G3/4 AE later on in treatment were significantly greater for subjects who experienced a G3/4 AE in their first cycle (OR 3.53, 95% CI 2.53–4.91, p < .0001). Conclusion Despite heterogeneous data collection protocols, PDS provides access to large datasets for novel outcomes analysis. In this paper, we demonstrate its utility for validating existing models and novel model generation including the utility of concomitant medications in

  3. Metrics for Cosmetology.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of cosmetology students, this instructional package on cosmetology is part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational terminology, measurement terms, and tools currently in use. Each of the…

  4. Surveillance Metrics Sensitivity Study

    SciTech Connect

    Bierbaum, R; Hamada, M; Robertson, A

    2011-11-01

    In September of 2009, a Tri-Lab team was formed to develop a set of metrics relating to the NNSA nuclear weapon surveillance program. The purpose of the metrics was to develop a more quantitative and/or qualitative metric(s) describing the results of realized or non-realized surveillance activities on our confidence in reporting reliability and assessing the stockpile. As a part of this effort, a statistical sub-team investigated various techniques and developed a complementary set of statistical metrics that could serve as a foundation for characterizing aspects of meeting the surveillance program objectives. The metrics are a combination of tolerance limit calculations and power calculations, intending to answer level-of-confidence type questions with respect to the ability to detect certain undesirable behaviors (catastrophic defects, margin insufficiency defects, and deviations from a model). Note that the metrics are not intended to gauge product performance but instead the adequacy of surveillance. This report gives a short description of four metrics types that were explored and the results of a sensitivity study conducted to investigate their behavior for various inputs. The results of the sensitivity study can be used to set the risk parameters that specify the level of stockpile problem that the surveillance program should be addressing.

  5. Surveillance metrics sensitivity study.

    SciTech Connect

    Hamada, Michael S.; Bierbaum, Rene Lynn; Robertson, Alix A.

    2011-09-01

    In September of 2009, a Tri-Lab team was formed to develop a set of metrics relating to the NNSA nuclear weapon surveillance program. The purpose of the metrics was to develop a more quantitative and/or qualitative metric(s) describing the results of realized or non-realized surveillance activities on our confidence in reporting reliability and assessing the stockpile. As a part of this effort, a statistical sub-team investigated various techniques and developed a complementary set of statistical metrics that could serve as a foundation for characterizing aspects of meeting the surveillance program objectives. The metrics are a combination of tolerance limit calculations and power calculations, intending to answer level-of-confidence type questions with respect to the ability to detect certain undesirable behaviors (catastrophic defects, margin insufficiency defects, and deviations from a model). Note that the metrics are not intended to gauge product performance but instead the adequacy of surveillance. This report gives a short description of four metrics types that were explored and the results of a sensitivity study conducted to investigate their behavior for various inputs. The results of the sensitivity study can be used to set the risk parameters that specify the level of stockpile problem that the surveillance program should be addressing.

  6. Metrics for Food Distribution.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of students interested in food distribution, this instructional package is one of five for the marketing and distribution cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational…

  7. Metrics for Transportation.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of students interested in transportation, this instructional package is one of five for the marketing and distribution cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational terminology,…

  8. Metrics for Blueprint Reading.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of blueprint reading students, this instructional package is one of eight for the manufacturing occupations cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational terminology, measurement…

  9. Arbitrary Metrics in Psychology

    ERIC Educational Resources Information Center

    Blanton, Hart; Jaccard, James

    2006-01-01

    Many psychological tests have arbitrary metrics but are appropriate for testing psychological theories. Metric arbitrariness is a concern, however, when researchers wish to draw inferences about the true, absolute standing of a group or individual on the latent psychological dimension being measured. The authors illustrate this in the context of 2…

  10. A Measured Metric Statement.

    ERIC Educational Resources Information Center

    Gaughan, Edward D.; Wisner, Robert J.

    1981-01-01

    A middle-road approach towards adopting the instruction of the metric system is presented. The realities of our cultural, economic, and political processes are taken into account and a 100 percent metric curriculum is viewed as unrealistic and anachronistic. (MP)

  11. Metrics for Fire Service.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of students interested in fire science education, this instructional package is one of two for the public service occupations cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational…

  12. Pyrethroid resistance in Phytoseiulus macropilis (Acari: Phytoseiidae): cross-resistance, stability and effect of synergists.

    PubMed

    Queiroz, Maria Cristina Vitelli; Sato, Mario Eidi

    2016-01-01

    Phytoseiulus macropilis Banks (Acari: Phytoseiidae) is an effective predator of Tetranychus urticae Koch (Acari: Tetranychidae). The objectives of this research were to study the stability of fenpropathrin resistance and the cross-resistance relationships with different pyrethroids, and also to evaluate the effect of synergists [piperonyl butoxide (PBO), diethyl maleate (DEM) and S,S,S-tributyl phosphorotrithioate (DEF)] on fenpropathrin resistant and susceptible strains of this predaceous mite. The stability of fenpropathrin resistance was studied under laboratory conditions, using P. macropilis populations with initial frequencies of 75 and 50% of resistant mites. The percentages of fenpropathrin resistant mites were evaluated monthly for a period of up to 12 months. A trend toward decreased resistance frequencies was observed only during the first 3-4 months. After this initial decrease, the fenpropathrin resistance was shown to be stable, maintaining constant resistance frequencies (around 30%) until the end of the evaluation period. Toxicity tests carried out using fenpropathrin resistant and susceptible strains of P. macropilis indicated strong positive cross-resistance between fenpropathrin and the pyrethroids bifenthrin and deltamethrin. Bioassays with the synergists DEM, DEF and PBO were also performed. The maximum synergism ratio (SR = LC50 without synergist/LC50 with synergist) detected for the three evaluated synergists (PBO, DEM, DEF) was 5.86 (for DEF), indicating low influence of enzyme detoxification processes in fenpropathrin resistance.

  13. SU-E-I-28: Introduction and Investigation of Effective Diameter Ratios as a New Patient Size Metric for Use in CT

    SciTech Connect

    Lamoureux, R; Sinclair, L; Mench, A; Lipnharski, I; Carranza, C; Bidari, S; Cormack, B; Rill, L; Arreola, M

    2015-06-15

    Purpose: To introduce and investigate effective diameter ratios as a new patient metric for use in computed tomography protocol selection as a supplement to patient-specific size parameter data. Methods: The metrics of outer effective diameter and inner effective diameter were measured for 7 post-mortem subjects scanned with a standardized chest/abdomen/pelvis (CAP) protocol on a 320-slice MDCT scanner. The outer effective diameter was calculated by obtaining the anterior/posterior and lateral dimensions of the imaged anatomy at the middle of the scan range using Effective Diameter= SQRT(AP height*Lat Width). The inner effective diameter was calculated with the same equation using the AP and Lat dimensions of the anatomy excluding the adipose tissue. The ratio of outer to inner effective diameter was calculated for each subject. A relationship to BMI, weight, and CTDI conversion coefficients was investigated. Results: For the largest subject with BMI of 43.85 kg/m2 and weight of 255 lbs the diameter ratio was calculated as 1.33. For the second largest subject with BMI of 33.5 kg/m2 and weight of 192.4 lbs the diameter ratio was measured as 1.43, indicating a larger percentage of adipose tissue in the second largest subject’s anatomical composition. For the smallest subject at BMI of 17.4 kg/m2 and weight of 86 lbs a similar tissue composition was indicated as a subject with BMI of 24.2 kg/m2 and weight of 136 lbs as they had the same diameter ratios of 1.11. Conclusion: The diameter ratio proves to contain information about anatomical composition that the BMI and weight alone do not. The utility of this metric is still being examined but could prove useful for determining MDCT techniques and for giving a more in depth detail of the composition of a patient’s body habitus.

  14. Effectiveness of amiodarone in resistant arrhythmias1

    PubMed Central

    Hollman, Arthur; Holt, Phyllis M

    1980-01-01

    Amiodarone is used in the treatment of previously drug-resistant supraventricular and ventricular arrhythmias. We report our experience with amiodarone in 8 patients. Five patients had paroxysmal atrial flutter, one had paroxysmal atrial fibrillation, one had supraventricular tachycardia, and one ventricular tachycardia. Considerable improvement, both objectively and subjectively, was observed in all patients. Side effects were as follows: all patients had corneal microdeposits, one developed left bundle branch block which resolved on stopping amiodarone, and one reported constipation and abdominal pains. Six patients have been treated for 10–28 months; 3 developed tolerance at 4–14 months after the introduction of amiodarone therapy, but symptoms improved with increased dosage. It is important to watch for the development of tolerance to this drug. PMID:7452643

  15. A metric for success

    NASA Astrophysics Data System (ADS)

    Carver, Gary P.

    1994-05-01

    The federal agencies are working with industry to ease adoption of the metric system. The goal is to help U.S. industry compete more successfully in the global marketplace, increase exports, and create new jobs. The strategy is to use federal procurement, financial assistance, and other business-related activities to encourage voluntary conversion. Based upon the positive experiences of firms and industries that have converted, federal agencies have concluded that metric use will yield long-term benefits that are beyond any one-time costs or inconveniences. It may be time for additional steps to move the Nation out of its dual-system comfort zone and continue to progress toward metrication. This report includes 'Metric Highlights in U.S. History'.

  16. An Arithmetic Metric

    ERIC Educational Resources Information Center

    Dominici, Diego

    2011-01-01

    This work introduces a distance between natural numbers not based on their position on the real line but on their arithmetic properties. We prove some metric properties of this distance and consider a possible extension.

  17. Sustainability Indicators and Metrics

    EPA Science Inventory

    Sustainability is about preserving human existence. Indicators and metrics are absolutely necessary to provide at least a semi-quantitative assessment of progress towards or away from sustainability. Otherwise, it becomes impossible to objectively assess whether progress is bei...

  18. The effect of vacuum annealing on corrosion resistance of titanium

    SciTech Connect

    Chikanov, V.N.; Peshkov, V.V.; Kireev, L.S.

    1994-09-01

    The effect of annealing on the corrosion resistance of OT4-1 sheet titanium in 25% HCl under various air pressures and self-evacuating conditions has been investigated. From the kinetic corrosion curves it follows that the least corrosion resistance of titanium is observed after vacuum annealing. Even low residual air pressure in a chamber improves corrosion resistance. The corrosion resistance of titanium decreases with vacuum-annealing time.

  19. Enterprise Sustainment Metrics

    DTIC Science & Technology

    The Air Force sustainment enterprise does not have metrics that . . . adequately measure key sustainment parameters, according to the 2011 National...Research Council of the National Academies study, Examination of the U.S. Air Force’s Aircraft Sustainment Needs in the Future and Its Strategy to Meet...standardized and do not contribute to the overall assessment of the sustainment enterprise. This paper explores the development of a single metric

  20. Guidelines for metrication at Lawrence Berkeley Laboratory

    SciTech Connect

    Not Available

    1993-07-01

    This document provides a set of guidelines for the metric transition process already under way at Lawrence Berkeley Laboratory. LBL has embarked upon this course in response to Section 5164 of the Trade and Competitiveness Act of 1988, Executive Order 12770 of 1991, and DOE Order 5900.2. The core provision of DOE Order 5900.2 is Section 7b, which states: {open_quotes}Metric usage shall be required except to the extent that such use is impractical, or is likely to cause significant inefficiencies to, or loss of markets by United States firms, or an inability of the Department to fulfill its responsibilities under the laws of the Federal Government and the United States.{close_quotes} LBL`s metrication policy is meant to comply with this requirement by aggressively fostering metrication. The purpose of these guidelines is to optimize the coherence and the cost-effectiveness of the metrication process.

  1. Thermoelectric Seebeck effect in oxide-based resistive switching memory.

    PubMed

    Wang, Ming; Bi, Chong; Li, Ling; Long, Shibing; Liu, Qi; Lv, Hangbing; Lu, Nianduan; Sun, Pengxiao; Liu, Ming

    2014-08-20

    Reversible resistive switching induced by an electric field in oxide-based resistive switching memory shows a promising application in future information storage and processing. It is believed that there are some local conductive filaments formed and ruptured in the resistive switching process. However, as a fundamental question, how electron transports in the formed conductive filament is still under debate due to the difficulty to directly characterize its physical and electrical properties. Here we investigate the intrinsic electronic transport mechanism in such conductive filament by measuring thermoelectric Seebeck effects. We show that the small-polaron hopping model can well describe the electronic transport process for all resistance states, although the corresponding temperature-dependent resistance behaviours are contrary. Moreover, at low resistance states, we observe a clear semiconductor-metal transition around 150 K. These results provide insight in understanding resistive switching process and establish a basic framework for modelling resistive switching behaviour.

  2. Thermoelectric Seebeck effect in oxide-based resistive switching memory

    PubMed Central

    Wang, Ming; Bi, Chong; Li, Ling; Long, Shibing; Liu, Qi; Lv, Hangbing; Lu, Nianduan; Sun, Pengxiao; Liu, Ming

    2014-01-01

    Reversible resistive switching induced by an electric field in oxide-based resistive switching memory shows a promising application in future information storage and processing. It is believed that there are some local conductive filaments formed and ruptured in the resistive switching process. However, as a fundamental question, how electron transports in the formed conductive filament is still under debate due to the difficulty to directly characterize its physical and electrical properties. Here we investigate the intrinsic electronic transport mechanism in such conductive filament by measuring thermoelectric Seebeck effects. We show that the small-polaron hopping model can well describe the electronic transport process for all resistance states, although the corresponding temperature-dependent resistance behaviours are contrary. Moreover, at low resistance states, we observe a clear semiconductor–metal transition around 150 K. These results provide insight in understanding resistive switching process and establish a basic framework for modelling resistive switching behaviour. PMID:25141267

  3. Marketing metrics for medical practices.

    PubMed

    Zahaluk, David; Baum, Neil

    2012-01-01

    There's a saying by John Wanamaker who pontificated, "Half the money I spend on advertising is wasted; the trouble is, I don't know which half". Today you have opportunities to determine which parts of your marketing efforts are effective and what is wasted. However, you have to measure your marketing results. This article will discuss marketing metrics and how to use them to get the best bang for your marketing buck.

  4. Application of bilateral filtration with weight coefficients for similarity metric calculation in optical flow computation algorithm

    NASA Astrophysics Data System (ADS)

    Panin, S. V.; Titkov, V. V.; Lyubutin, P. S.; Chemezov, V. O.; Eremin, A. V.

    2016-11-01

    Application of weight coefficients of the bilateral filter used to determine weighted similarity metrics of image ranges in optical flow computation algorithm that employs 3-dimension recursive search (3DRS) was investigated. By testing the algorithm applying images taken from the public test database Middlebury benchmark, the effectiveness of this weighted similarity metrics for solving the image processing problem was demonstrated. The necessity of matching the equation parameter values when calculating the weight coefficients aimed at taking into account image texture features was proved for reaching the higher noise resistance under the vector field construction. The adaptation technique which allows excluding manual determination of parameter values was proposed and its efficiency was demonstrated.

  5. Effects of atmospheric moisture on rock resistivity.

    NASA Technical Reports Server (NTRS)

    Alvarez, R.

    1973-01-01

    This study examines the changes in resistivity of rock samples as induced by atmospheric moisture. Experiments were performed on samples of hematitic sandstone, pyrite, and galena. The sandstone underwent a change in resistivity of four orders of magnitude when it was measured in a vacuum of 500 ntorr and in air of 37% relative humidity. Pyrite and galena showed no variations in resistivity when they were measured under the same conditions. These results, plus others obtained elsewhere, indicate that rocks of the resistive type are affected in their electrical properties by atmospheric moisture, whereas rocks of the conductive type are not. The experimental evidence obtained is difficult to reconcile with a model of aqueous electrolytic conduction on the sample surface. It is instead suggested that adsorbed water molecules alter the surface resistivity in a manner similar to that observed in semiconductors and insulators.

  6. U.S. Metric Study Interim Report: The Consumer.

    ERIC Educational Resources Information Center

    National Bureau of Standards (DOC), Washington, DC.

    This is the seventh in a series of reports from the U. S. Metric Study, conducted by the National Bureau of Standards, focusing on the effects of increasing metric usage on the consumer American. Information on three areas--the level of knowledge of the American about the metric system, problems which would be encountered with a national policy of…

  7. A two dimensional analysis of sheet resistance and contact resistance effects in solar cells

    NASA Technical Reports Server (NTRS)

    Fang, C. R.; Hauser, J. R.

    1978-01-01

    A computer model is developed to study the two-dimensional nature of the sheet resistance and contact resistance effects in solar cells. A major result is the demonstration that the distributed nature of the semiconductor sheet resistance causes the terminal dark I-V characteristics to exhibit an exp(qV/2kT) type dependence even when the one-dimensional characteristics of the cell exhibit an exp(qV/kT) type voltage dependence. The analytical model which is developed provides an easy method for estimating the sheet resistance of a solar cell from the terminal I-V data.

  8. Successful Experiences in Teaching Metric.

    ERIC Educational Resources Information Center

    Odom, Jeffrey V., Ed.

    In this publication are presentations on specific experiences in teaching metrics, made at a National Bureau of Standards conference. Ideas of value to teachers and administrators are described in reports on: SI units of measure; principles and practices of teaching metric; metric and the school librarian; teaching metric through television and…

  9. Effect of ampicillin, streptomycin, penicillin and tetracycline on metal resistant and non-resistant Staphylococcus aureus.

    PubMed

    Chudobova, Dagmar; Dostalova, Simona; Blazkova, Iva; Michalek, Petr; Ruttkay-Nedecky, Branislav; Sklenar, Matej; Nejdl, Lukas; Kudr, Jiri; Gumulec, Jaromir; Tmejova, Katerina; Konecna, Marie; Vaculovicova, Marketa; Hynek, David; Masarik, Michal; Kynicky, Jindrich; Kizek, Rene; Adam, Vojtech

    2014-03-19

    There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects of antibiotics on Staphylococcus aureus non-resistant strain and strains resistant to cadmium or lead ions. Metal resistant strains were created by the gradual addition of 2 mM solution of metal ions (cadmium or lead) to the S. aureus culture. An increasing antimicrobial effect of ampicillin, streptomycin, penicillin and tetracycline (0, 10, 25, 50, 75, 150, 225 and 300 µM) on the resistant strains was observed using a method of growth curves. A significant growth inhibition (compared to control) of cadmium resistant cells was observed in the presence of all the four different antibiotics. On the other hand, the addition of streptomycin and ampicillin did not inhibit the growth of lead resistant strain. Other antibiotics were still toxic to the bacterial cells. Significant differences in the morphology of cell walls were indicated by changes in the cell shape. Our data show that the presence of metal ions in the urban environment may contribute to the development of bacterial strain resistance to other substances including antibiotics, which would have an impact on public health.

  10. Effect of Ampicillin, Streptomycin, Penicillin and Tetracycline on Metal Resistant and Non-Resistant Staphylococcus aureus

    PubMed Central

    Chudobova, Dagmar; Dostalova, Simona; Blazkova, Iva; Michalek, Petr; Ruttkay-Nedecky, Branislav; Sklenar, Matej; Nejdl, Lukas; Kudr, Jiri; Gumulec, Jaromir; Tmejova, Katerina; Konecna, Marie; Vaculovicova, Marketa; Hynek, David; Masarik, Michal; Kynicky, Jindrich; Kizek, Rene; Adam, Vojtech

    2014-01-01

    There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects of antibiotics on Staphylococcus aureus non-resistant strain and strains resistant to cadmium or lead ions. Metal resistant strains were created by the gradual addition of 2 mM solution of metal ions (cadmium or lead) to the S. aureus culture. An increasing antimicrobial effect of ampicillin, streptomycin, penicillin and tetracycline (0, 10, 25, 50, 75, 150, 225 and 300 µM) on the resistant strains was observed using a method of growth curves. A significant growth inhibition (compared to control) of cadmium resistant cells was observed in the presence of all the four different antibiotics. On the other hand, the addition of streptomycin and ampicillin did not inhibit the growth of lead resistant strain. Other antibiotics were still toxic to the bacterial cells. Significant differences in the morphology of cell walls were indicated by changes in the cell shape. Our data show that the presence of metal ions in the urban environment may contribute to the development of bacterial strain resistance to other substances including antibiotics, which would have an impact on public health. PMID:24651395

  11. Effects of cost metric on cost-effectiveness of protected-area network design in urban landscapes.

    PubMed

    Burkhalter, J C; Lockwood, J L; Maslo, B; Fenn, K H; Leu, K

    2016-04-01

    A common goal in conservation planning is to acquire areas that are critical to realizing biodiversity goals in the most cost-effective manner. The way monetary acquisition costs are represented in such planning is an understudied but vital component to realizing cost efficiencies. We sought to design a protected-area network within a forested urban region that would protect 17 birds of conservation concern. We compared the total costs and spatial structure of the optimal protected-area networks produced using three acquisition-cost surrogates (area, agricultural land value, and tax-assessed land value). Using the tax-assessed land values there was a 73% and 78% cost savings relative to networks derived using area or agricultural land value, respectively. This cost reduction was due to the considerable heterogeneity in acquisition costs revealed in tax-assessed land values, especially for small land parcels, and the corresponding ability of the optimization algorithm to identify lower-cost parcels for inclusion that had equal value to our target species. Tax-assessed land values also reflected the strong spatial differences in acquisition costs (US$0.33/m(2)-$55/m(2)) and thus allowed the algorithm to avoid inclusion of high-cost parcels when possible. Our results add to a nascent but growing literature that suggests conservation planners must consider the cost surrogate they use when designing protected-area networks. We suggest that choosing cost surrogates that capture spatial- and size-dependent heterogeneity in acquisition costs may be relevant to establishing protected areas in urbanizing ecosystems.

  12. Characterization of the fetal diaphragmatic magnetomyogram and the effect of breathing movements on cardiac metrics of rate and variability.

    PubMed

    Gustafson, Kathleen M; Allen, John J B; Yeh, Hung-Wen; May, Linda E

    2011-07-01

    Breathing movements are one of the earliest fetal motor behaviors to emerge and are a hallmark of fetal well-being. Fetal respiratory sinus arrhythmia (RSA) has been documented but efforts to quantify the influence of breathing on heart rate (HR) and heart rate variability (HRV) are difficult due to the episodic nature of fetal breathing activity. We used a dedicated fetal biomagnetometer to acquire the magnetocardiogram (MCG) between 36 and 38 weeks gestational age (GA). We identified and characterized a waveform observed in the raw data and independent component decomposition that we attribute to fetal diaphragmatic movements during breathing episodes. RSA and increased high frequency power in a time-frequency analysis of the IBI time-series was observed during fetal breathing periods. Using the diaphragmatic magnetomyogram (dMMG) as a marker, we compared time and frequency domain metrics of heart rate and heart rate variability between breathing and non-breathing epochs. Fetal breathing activity resulted in significantly lower HR, increased high frequency power, greater sympathovagal balance, increased short-term HRV and greater parasympathetic input relative to non-breathing episodes confirming the specificity of fetal breathing movements on parasympathetic cardiac influence. No significant differences between breathing and non-breathing epochs were found in two metrics reflecting total HRV or very low, low and intermediate frequency bands. Using the fetal dMMG as a marker, biomagnetometry can help to elucidate the electrophysiologic mechanisms associated with diaphragmatic motor function and may be used to study the longitudinal development of human fetal cardiac autonomic control and breathing activity.

  13. Characterization of the Fetal Diaphragmatic Magnetomyogram and the Effect of Breathing Movements on Cardiac Metrics of Rate and Variability

    PubMed Central

    Gustafson, Kathleen M.; Allen, John J. B.; Yeh, Hung-wen; May, Linda E.

    2011-01-01

    Breathing movements are one of the earliest fetal motor behaviors to emerge andare ahallmark of fetal well-being. Fetal respiratory sinus arrhythmia (RSA) has been documented but efforts to quantify the influence of breathing on heart rate (HR) and heart rate variability (HRV) are difficult due to the episodic nature of fetal breathing activity. We used a dedicated fetal biomagnetometer to acquire the magnetocardiogram (MCG) between 36-38 weeks gestational age (GA). We identified and characterized a waveform observed in the raw data and independent component decomposition that we attribute to fetal diaphragmatic movements during breathing episodes. RSA and increased high frequency power in a time-frequency analysis of the IBI time-series was observed during fetal breathing periods. Using the diaphragmatic magnetomyogram (dMMG) as a marker, we compared time and frequency domain metrics of heartrate and heart rate variability between breathing and non-breathing epochs. Fetal breathing activity resulted in significantly lower HR, increased high frequency power, greater sympathovagal balance, increased short-term HRV andgreater parasympathetic input relative to non-breathing episodesconfirming the specificity of fetal breathing movements on parasympathetic cardiac influence. No significant differences between breathing and non-breathing epochs were found in two metrics reflecting total HRVor very low, low and intermediate frequency bands. Using the fetal dMMG as a marker, biomagnetometry can help to elucidate the electrophysiologic mechanisms associated with diaphragmatic motor function and may be used to study the longitudinal development of human fetal cardiac autonomic control and breathing activity. PMID:21497027

  14. Overlay quality metric

    NASA Astrophysics Data System (ADS)

    Cohen, Guy; Amit, Eran; Klein, Dana; Kandel, Daniel; Levinski, Vladimir B.

    2012-03-01

    As overlay budget continues to shrink, an improved analysis of the different contributors to this budget is needed. A major contributor that has never been quantified is the accuracy of the measurements. KLA-Tencor developed a quality metric, that calculates and attaches an accuracy value to each OVL target. This operation is performed on the fly during measurement and can be applied without affecting MAM time or throughput. Using a linearity array we demonstrate that the quality metric identifies targets deviating from the intended OVL value, with no false alarms.

  15. Feasibility of a cost-effective, video analysis software-based mobility protocol for objective spine kinematics and gait metrics: a proof of concept study.

    PubMed

    Paul, Justin C; Petrizzo, Anthony; Rizzo, John-Ross; Bianco, Kristina; Maier, Stephen; Errico, Thomas J; Lafage, Virginie

    2015-03-01

    The purpose of this study was to investigate the potential of a high-throughput, easily implemented, cost-effective, video analysis software-based mobility protocol to quantify spine kinematics. This prospective cohort study of clinical biomechanics implemented 2-dimensional (2D) image processing at a tertiary-care academic institution. Ten healthy, able-bodied volunteers were recruited for 2D videography of gait and functional motion. The reliability of a 2D video analysis software program for gait and range of motion metrics was evaluated over 2 independent experimental sessions, assessing for inter-trial, inter-session, and inter-rater reliability. Healthy volunteers were evaluated for simple forward and side bending, rotation, treadmill stride length, and more complex seated-to-standing tasks. Based on established intraclass correlation coefficients, results indicated that reliability was considered good to excellent for simple forward and side bending, rotation, stride length, and more complex sit-to-standing tasks. In conclusion, a cost-effective, 2D, video analysis software-based mobility protocol represents a feasible and clinically useful approach for objective spine kinematics and gait metrics. As the complication rate of operative management in the setting of spinal deformity is weighed against functional performance and quality of life measures, an objective analysis tool in combination with an appropriate protocol will aid in clinical assessments and lead to an increased evidence base for management options and decision algorithms.

  16. Feasibility of a Cost-Effective, Video Analysis Software–Based Mobility Protocol for Objective Spine Kinematics and Gait Metrics: A Proof of Concept Study

    PubMed Central

    Paul, Justin C.; Petrizzo, Anthony; Rizzo, John-Ross; Bianco, Kristina; Maier, Stephen; Errico, Thomas J.; Lafage, Virginie

    2015-01-01

    The purpose of this study was to investigate the potential of a high-throughput, easily implemented, cost-effective, video analysis software–based mobility protocol to quantify spine kinematics. This prospective cohort study of clinical biomechanics implemented 2-dimensional (2D) image processing at a tertiary-care academic institution. Ten healthy, able-bodied volunteers were recruited for 2D videography of gait and functional motion. The reliability of a 2D video analysis software program for gait and range of motion metrics was evaluated over 2 independent experimental sessions, assessing for inter-trial, inter-session, and inter-rater reliability. Healthy volunteers were evaluated for simple forward and side bending, rotation, treadmill stride length, and more complex seated-to-standing tasks. Based on established intraclass correlation coefficients, results indicated that reliability was considered good to excellent for simple forward and side bending, rotation, stride length, and more complex sit-to-standing tasks. In conclusion, a cost-effective, 2D, video analysis software–based mobility protocol represents a feasible and clinically useful approach for objective spine kinematics and gait metrics. As the complication rate of operative management in the setting of spinal deformity is weighed against functional performance and quality of life measures, an objective analysis tool in combination with an appropriate protocol will aid in clinical assessments and lead to an increased evidence base for management options and decision algorithms. PMID:25543099

  17. Effect of Tulathromycin on Colonization Resistance, Antimicrobial Resistance, and Virulence of Human Gut Microbiota in Chemostats

    PubMed Central

    Hao, Haihong; Zhou, Shengxi; Cheng, Guyue; Dai, Menghong; Wang, Xu; Liu, Zhenli; Wang, Yulian; Yuan, Zonghui

    2016-01-01

    To evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1, 10, and 100 μg/mL) was added into Chemostats. Before and after drug exposure, we monitored (1) population, SCFA products, antimicrobial resistance, and colonization resistance of gut microbiota, and (2) the antimicrobial resistance genes, transferability, virulent genes, pathogenicity of Enterococus faecalis. Results showed that low level of tulathromycin did not exhibit microbiological hazard on resistance selection and colonization resistance. However, high level of tulathromycin (10 and 100 μg/mL) may disturb colonization resistance of human gut microbiota and select antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried resistant gene of ermB, transferable element of Tn1545 and three virulence genes (esp, cylA, and ace). One of them (E. faecalis 143) was confirmed to have higher horizontal transfer risk and higher pathogenicity. The calculated no observable adverse effect concentration (NOAEC) and microbiological acceptable daily intake (mADI) in our study was 1 μg/mL and 14.66 μg/kg.bw/day, respectively. PMID:27092131

  18. Unraveling the effect of resist composition on EUV optics contamination

    NASA Astrophysics Data System (ADS)

    Pollentier, I.; Neira, I.; Goethals, A.-M.; Gronheid, R.; Tarutani, S.; Tamaoki, H.; Tsubaki, H.; Takahashi, T.

    2011-04-01

    EUV lithography is the most promising new technology for the next node of semiconductor devices. Unfortunately, the high energy photons are likely to generate more contamination than observed with ArF or KrF light which can reduce the transmission of the EUV optics. Resist outgassing is considered to be an important contamination source, however, not enough is known about the way a resist composition influences the contamination growth rate, while this information is crucial to guide the development of EUV resists. To reduce the knowledge gap, FUJIFILM and imec started a joint effort aimed at systematically exploring the contribution of the different resist components and at understanding the effect of chemical modifications of the different components on the contamination tendency of resists. The project focuses on (1) the identification and quantification of the outgassing components from resist by RGA measurements, (2) on the quantification of the resist related contamination rate by witness sample (WS) testing, and (3) on the correlation between these two results knowing the details of the resist chemistry. To explore the effect of the resist composition upon contamination growth, the following approach was followed. The focus was put on chemically amplified resists (CAR), since this chemistry is mostly used in EUV lithography. Both PAG blended as well as PAG bound systems were explored, and the following resist components are individually varied: polymer matrix, blocking groups, PAG type and concentration. In this way the total contamination of a resist can be divided into the separate contributions of the different resist components upon the contamination growth rate, which is a huge step forward in the understanding of optics contamination due to resist.

  19. Radiation Effects of Commercial Resistive Random Access Memories

    NASA Technical Reports Server (NTRS)

    Chen, Dakai; LaBel, Kenneth A.; Berg, Melanie; Wilcox, Edward; Kim, Hak; Phan, Anthony; Figueiredo, Marco; Buchner, Stephen; Khachatrian, Ani; Roche, Nicolas

    2014-01-01

    We present results for the single-event effect response of commercial production-level resistive random access memories. We found that the resistive memory arrays are immune to heavy ion-induced upsets. However, the devices were susceptible to single-event functional interrupts, due to upsets from the control circuits. The intrinsic radiation tolerant nature of resistive memory makes the technology an attractive consideration for future space applications.

  20. Metrics of Scholarly Impact

    ERIC Educational Resources Information Center

    Cacioppo, John T.; Cacioppo, Stephanie

    2012-01-01

    Ruscio and colleagues (Ruscio, Seaman, D'Oriano, Stremlo, & Mahalchik, this issue) provide a thoughtful empirical analysis of 22 different measures of individual scholarly impact. The simplest metric is number of publications, which Simonton (1997) found to be a reasonable predictor of career trajectories. Although the assessment of the scholarly…

  1. Metrics and Sports.

    ERIC Educational Resources Information Center

    National Collegiate Athletic Association, Shawnee Mission, KS.

    Designed as a guide to aid the National Collegiate Athletic Association membership and others who must relate measurement of distances, weights, and volumes to athletic activity, this document presents diagrams of performance areas with measurements delineated in both imperial and metric terms. Illustrations are given for baseball, basketball,…

  2. Software Quality Metrics

    DTIC Science & Technology

    1991-07-01

    March 1979, pp. 121-128. Gorla, Narasimhaiah, Alan C. Benander, and Barbara A. Benander, "Debugging Effort Estimation Using Software Metrics", IEEE...Society, IEEE Guide for the Use of IEEE Standard Dictionary of Measures to Produce Reliable Software, IEEE Std 982.2-1988, June 1989. Jones, Capers

  3. Metrical Phonology and SLA.

    ERIC Educational Resources Information Center

    Tice, Bradley S.

    Metrical phonology, a linguistic process of phonological stress assessment and diagrammatic simplification of sentence and word stress, is discussed as it is found in the English language with the intention that it may be used in second language instruction. Stress is defined by its physical and acoustical correlates, and the principles of…

  4. Latitudinal variation of the effect of aviation NOx emissions on atmospheric ozone and methane and related climate metrics

    NASA Astrophysics Data System (ADS)

    Köhler, M. O.; Rädel, G.; Shine, K. P.; Rogers, H. L.; Pyle, J. A.

    2013-01-01

    We evaluate the response to regional and latitudinal changes in aircraft NOx emissions using several climate metrics (radiative forcing (RF), Global Warming Potential (GWP), Global Temperature change Potential (GTP)). Global chemistry transport model integrations were performed with sustained perturbations in regional aircraft and aircraft-like NOx emissions. The RF due to the resulting ozone and methane changes is then calculated. We investigate the impact of emission changes for specific geographical regions (approximating to USA, Europe, India and China) and cruise altitude emission changes in discrete latitude bands covering both hemispheres. We find that lower latitude emission changes (per Tg N) cause ozone and methane RFs that are about a factor of 6 larger than those from higher latitude emission changes. The net RF is positive for all experiments. The meridional extent of the RF is larger for low latitude emissions. GWPs for all emission changes are positive, with tropical emissions having the largest values; the sign of the GTP depends on the choice of time horizon.

  5. The nature of spacetime in bigravity: Two metrics or none?

    NASA Astrophysics Data System (ADS)

    Akrami, Yashar; Koivisto, Tomi S.; Solomon, Adam R.

    2015-01-01

    The possibility of matter coupling to two metrics at once is considered. This appears natural in the most general ghost-free, bimetric theory of gravity, where it unlocks an additional symmetry with respect to the exchange of the metrics. This double coupling, however, raises the problem of identifying the observables of the theory. It is shown that if the two metrics couple minimally to matter, then there is no physical metric to which all matter would universally couple, and that moreover such an effective metric generically does not exist even for an individual matter species. By studying point particle dynamics, a resolution is suggested in the context of Finsler geometry.

  6. Effects of Transgenic Glyphosate-Resistant Crops on Water Quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Glyphosate (N-[phosphonomethyl] glycine) is a highly effective, non-selective herbicide. Herbicide-resistant crop (HRC) has been the most successful trait used in transgenic crops throughout the world. Transgenic glyphosate-resistant crops (GRCs) have been commercialized and grown extensively in the...

  7. Do metrical accents create illusory phenomenal accents?

    PubMed

    Repp, Bruno H

    2010-07-01

    In music that is perceived as metrically structured, events coinciding with the main beat are called metrically accented. Are these accents purely cognitive, or do they perhaps represent illusory increases in perceived loudness or duration, caused by heightened attention to main beats? In four separate tasks, musicians tried to detect a small actual increase or decrease in the loudness or duration of a single note in melodies comprising 12 notes. Musical notation prescribed a meter (6/8) implying a main beat coinciding with every third note. Effects of metrical accentuation on detection performance were found in all four tasks. However, they reflected primarily an increase in sensitivity to physical changes in main beat positions, likely to be due to enhanced attention. There was no evidence of biases indicating illusory phenomenal accents in those positions. By contrast, and independent of metrical structure, pitch accents due to pitch contour pivots were often mistaken for increases in loudness.

  8. Peltier-Effect-Induced Correction to Ohmic Resistance

    NASA Astrophysics Data System (ADS)

    Cheremisin, M. V.

    2001-02-01

    The standard ohmic measurements by means of two extra leads contain an additional thermal correction to resistance. The current results in heating(cooling) at first(second) sample contact due to Peltier effect. The contacts temperatures are different. The measured voltage is the sum of the ohmic voltage swing and Peltier effect induced thermopower which is linear on current. As a result, the thermal correction to resistance measured exists at $I\\to 0$. The correction should be in comparison with ohmic resistance. Above some critical frequency dependent on thermal inertial effects the thermal correction disappears.

  9. Hybrid metric-Palatini stars

    NASA Astrophysics Data System (ADS)

    Danilǎ, Bogdan; Harko, Tiberiu; Lobo, Francisco S. N.; Mak, M. K.

    2017-02-01

    We consider the internal structure and the physical properties of specific classes of neutron, quark and Bose-Einstein condensate stars in the recently proposed hybrid metric-Palatini gravity theory, which is a combination of the metric and Palatini f (R ) formalisms. It turns out that the theory is very successful in accounting for the observed phenomenology, since it unifies local constraints at the Solar System level and the late-time cosmic acceleration, even if the scalar field is very light. In this paper, we derive the equilibrium equations for a spherically symmetric configuration (mass continuity and Tolman-Oppenheimer-Volkoff) in the framework of the scalar-tensor representation of the hybrid metric-Palatini theory, and we investigate their solutions numerically for different equations of state of neutron and quark matter, by adopting for the scalar field potential a Higgs-type form. It turns out that the scalar-tensor definition of the potential can be represented as an Clairaut differential equation, and provides an explicit form for f (R ) given by f (R )˜R +Λeff, where Λeff is an effective cosmological constant. Furthermore, stellar models, described by the stiff fluid, radiation-like, bag model and the Bose-Einstein condensate equations of state are explicitly constructed in both general relativity and hybrid metric-Palatini gravity, thus allowing an in-depth comparison between the predictions of these two gravitational theories. As a general result it turns out that for all the considered equations of state, hybrid gravity stars are more massive than their general relativistic counterparts. Furthermore, two classes of stellar models corresponding to two particular choices of the functional form of the scalar field (constant value, and logarithmic form, respectively) are also investigated. Interestingly enough, in the case of a constant scalar field the equation of state of the matter takes the form of the bag model equation of state describing

  10. Prediction of Flow and Solute Transport in Fractured Media: Comparison of Metrics to Describe Effects of Rough Surfaces

    NASA Astrophysics Data System (ADS)

    Slottke, D.; Ketcham, R. A.; Sharp, J. M.

    2008-05-01

    Fractures dominate fluid flow and transport of solutes when they are open and connected. The prediction of flow through fractured media has implications for development of water resources, petroleum reservoir exploitation, contamination and remediation assessment, and site evaluation for waste repositories. Assessing the impact of surface roughness on fluid flow and solute transport through fractured media from samples on the order of 100 cm2 assumes the existence of a relationship between fracture morphology and discharge that is scale invariant or at least smoothly transformable. Although some studies assume that the length scale at which surface roughness significantly contributes to the discharge through a fracture falls within the size of a typical hand sample, there is a dearth of empirical data supporting an extension of the relationships found at small scales to larger samples. Furthermore, an appropriate metric to describe a fracture volume accurately must be chosen. We compile data from physical flow tests and numerical modeling of two discrete natural fractures of different scales in rhyolitc tuff. The University of Texas HRXCT facility provided computed tomography representations of the fractures that allow analysis of surface roughness and aperture statistics at 0.25mm grid resolution, which form the basis for transmissivity field inputs to numerical models. We show that although a small (10cm2) representative surface can describe roughness, aperture fields are not so well behaved. We compare physical flow test results, modeled flow, and analytical solutions of the cubic law using various methods of assigning a meaningful aperture to illustrate the challenges of accurate modeling of fracture flow without a priori flow information. While a geometric mean aperture of the entire aperture field closely approximates the hydraulic aperture, an arbitrary profile mean aperture has little utility for predictive purposes.

  11. Quality Metrics in Endoscopy

    PubMed Central

    Gurudu, Suryakanth R.

    2013-01-01

    Endoscopy has evolved in the past 4 decades to become an important tool in the diagnosis and management of many digestive diseases. Greater focus on endoscopic quality has highlighted the need to ensure competency among endoscopists. A joint task force of the American College of Gastroenterology and the American Society for Gastrointestinal Endoscopy has proposed several quality metrics to establish competence and help define areas of continuous quality improvement. These metrics represent quality in endoscopy pertinent to pre-, intra-, and postprocedural periods. Quality in endoscopy is a dynamic and multidimensional process that requires continuous monitoring of several indicators and benchmarking with local and national standards. Institutions and practices should have a process in place for credentialing endoscopists and for the assessment of competence regarding individual endoscopic procedures. PMID:24711767

  12. Metrics for Energy Resilience

    SciTech Connect

    Paul E. Roege; Zachary A. Collier; James Mancillas; John A. McDonagh; Igor Linkov

    2014-09-01

    Energy lies at the backbone of any advanced society and constitutes an essential prerequisite for economic growth, social order and national defense. However there is an Achilles heel to today?s energy and technology relationship; namely a precarious intimacy between energy and the fiscal, social, and technical systems it supports. Recently, widespread and persistent disruptions in energy systems have highlighted the extent of this dependence and the vulnerability of increasingly optimized systems to changing conditions. Resilience is an emerging concept that offers to reconcile considerations of performance under dynamic environments and across multiple time frames by supplementing traditionally static system performance measures to consider behaviors under changing conditions and complex interactions among physical, information and human domains. This paper identifies metrics useful to implement guidance for energy-related planning, design, investment, and operation. Recommendations are presented using a matrix format to provide a structured and comprehensive framework of metrics relevant to a system?s energy resilience. The study synthesizes previously proposed metrics and emergent resilience literature to provide a multi-dimensional model intended for use by leaders and practitioners as they transform our energy posture from one of stasis and reaction to one that is proactive and which fosters sustainable growth.

  13. Effects of experimentally-enhanced precipitation and nitrogen on resistance, recovery and resilience of a semi-arid grassland after drought.

    PubMed

    Xu, Zhuwen; Ren, Haiyan; Cai, Jiangping; Wang, Ruzhen; Li, Mai-He; Wan, Shiqiang; Han, Xingguo; Lewis, Bernard J; Jiang, Yong

    2014-12-01

    Resistance, recovery and resilience are three important properties of ecological stability, but they have rarely been studied in semi-arid grasslands under global change. We analyzed data from a field experiment conducted in a native grassland in northern China to explore the effects of experimentally enhanced precipitation and N deposition on both absolute and relative measures of community resistance, recovery and resilience--calculated in terms of community cover--after a natural drought. For both absolute and relative measures, communities with precipitation enhancement showed higher resistance and lower recovery, but no change in resilience compared to communities with ambient precipitation in the semi-arid grassland. The manipulated increase in N deposition had little effect on these community stability metrics except for decreased community resistance. The response patterns of these stability metrics to alterations in precipitation and N are generally consistent at community, functional group and species levels. Contrary to our expectations, structural equation modeling revealed that water-driven community resistance and recovery result mainly from changes in community species asynchrony rather than species diversity in the semi-arid grassland. These findings suggest that changes in precipitation regimes may have significant impacts on the response of water-limited ecosystems to drought stress under global change scenarios.

  14. Metric Education Plan for Virginia.

    ERIC Educational Resources Information Center

    Virginia State Dept. of Education, Richmond. Div. of Secondary Education.

    This comprehensive document is the result of statewide planning for the implementation of metric education in Virginia schools. An introduction discusses the rationale, needs, and continuing objectives for metric education. An organizational structure for metric education in Virginia is outlined. Guidelines for administrative planning are…

  15. Metrication in a global environment

    NASA Technical Reports Server (NTRS)

    Aberg, J.

    1994-01-01

    A brief history about the development of the metric system of measurement is given. The need for the U.S. to implement the 'SI' metric system in the international markets, especially in the aerospace and general trade, is discussed. Development of metric implementation and experiences locally, nationally, and internationally are included.

  16. Some References on Metric Information.

    ERIC Educational Resources Information Center

    National Bureau of Standards (DOC), Washington, DC.

    This resource work lists metric information published by the U.S. Government and the American National Standards Institute. Also organizations marketing metric materials for education are given. A short table of conversions is included as is a listing of basic metric facts for everyday living. (LS)

  17. Metric Education for Adult Learners.

    ERIC Educational Resources Information Center

    Goetsch, David L.

    1978-01-01

    The metric education program developed at Okaloosa-Walton Junior College, Niceville, Florida, for students and the community in general consists of three components: a metric measurement course; multimedia labor for independent study; and metric signs located throughout the campus. Instructional approaches for adult students are noted. (MF)

  18. Metrics for Offline Evaluation of Prognostic Performance

    NASA Technical Reports Server (NTRS)

    Saxena, Abhinav; Celaya, Jose; Saha, Bhaskar; Saha, Sankalita; Goebel, Kai

    2010-01-01

    Prognostic performance evaluation has gained significant attention in the past few years. Currently, prognostics concepts lack standard definitions and suffer from ambiguous and inconsistent interpretations. This lack of standards is in part due to the varied end-user requirements for different applications, time scales, available information, domain dynamics, etc. to name a few. The research community has used a variety of metrics largely based on convenience and their respective requirements. Very little attention has been focused on establishing a standardized approach to compare different efforts. This paper presents several new evaluation metrics tailored for prognostics that were recently introduced and were shown to effectively evaluate various algorithms as compared to other conventional metrics. Specifically, this paper presents a detailed discussion on how these metrics should be interpreted and used. These metrics have the capability of incorporating probabilistic uncertainty estimates from prognostic algorithms. In addition to quantitative assessment they also offer a comprehensive visual perspective that can be used in designing the prognostic system. Several methods are suggested to customize these metrics for different applications. Guidelines are provided to help choose one method over another based on distribution characteristics. Various issues faced by prognostics and its performance evaluation are discussed followed by a formal notational framework to help standardize subsequent developments.

  19. Evaluating Algorithm Performance Metrics Tailored for Prognostics

    NASA Technical Reports Server (NTRS)

    Saxena, Abhinav; Celaya, Jose; Saha, Bhaskar; Saha, Sankalita; Goebel, Kai

    2009-01-01

    Prognostics has taken a center stage in Condition Based Maintenance (CBM) where it is desired to estimate Remaining Useful Life (RUL) of the system so that remedial measures may be taken in advance to avoid catastrophic events or unwanted downtimes. Validation of such predictions is an important but difficult proposition and a lack of appropriate evaluation methods renders prognostics meaningless. Evaluation methods currently used in the research community are not standardized and in many cases do not sufficiently assess key performance aspects expected out of a prognostics algorithm. In this paper we introduce several new evaluation metrics tailored for prognostics and show that they can effectively evaluate various algorithms as compared to other conventional metrics. Specifically four algorithms namely; Relevance Vector Machine (RVM), Gaussian Process Regression (GPR), Artificial Neural Network (ANN), and Polynomial Regression (PR) are compared. These algorithms vary in complexity and their ability to manage uncertainty around predicted estimates. Results show that the new metrics rank these algorithms in different manner and depending on the requirements and constraints suitable metrics may be chosen. Beyond these results, these metrics offer ideas about how metrics suitable to prognostics may be designed so that the evaluation procedure can be standardized. 1

  20. On Applying the Prognostic Performance Metrics

    NASA Technical Reports Server (NTRS)

    Saxena, Abhinav; Celaya, Jose; Saha, Bhaskar; Saha, Sankalita; Goebel, Kai

    2009-01-01

    Prognostics performance evaluation has gained significant attention in the past few years. As prognostics technology matures and more sophisticated methods for prognostic uncertainty management are developed, a standardized methodology for performance evaluation becomes extremely important to guide improvement efforts in a constructive manner. This paper is in continuation of previous efforts where several new evaluation metrics tailored for prognostics were introduced and were shown to effectively evaluate various algorithms as compared to other conventional metrics. Specifically, this paper presents a detailed discussion on how these metrics should be interpreted and used. Several shortcomings identified, while applying these metrics to a variety of real applications, are also summarized along with discussions that attempt to alleviate these problems. Further, these metrics have been enhanced to include the capability of incorporating probability distribution information from prognostic algorithms as opposed to evaluation based on point estimates only. Several methods have been suggested and guidelines have been provided to help choose one method over another based on probability distribution characteristics. These approaches also offer a convenient and intuitive visualization of algorithm performance with respect to some of these new metrics like prognostic horizon and alpha-lambda performance, and also quantify the corresponding performance while incorporating the uncertainty information.

  1. Effect of prolonged hypokinesia on resistance of resistive vessels in rats

    NASA Technical Reports Server (NTRS)

    Saltykova, V. A.

    1982-01-01

    Under the effect of prolonged hypokinesia, the perfusion pressure in resistive vessels, measured under conditions of deep anesthesia and complete denervation, increased by approximately the same degree as arterial pressure in non-anesthetized animals. The increase in arterial, perfusion pressure and the resistance of resistive vessels in animals subjected to prolonged hypokinesia was accompanied by an increase in adrenoreactivity. During prolonged hypokinesia, partial obliteration of the vascular bed of the skeletal muscles plays a significant role in the observed increase in resistance of vessels of the extremities. The increase in adrenoreactivity of the vessels during hypokinesia may be realized as a partial case of an increase in the adrenoreactivity of structures whose innervation is disturbed.

  2. Implicit Contractive Mappings in Modular Metric and Fuzzy Metric Spaces

    PubMed Central

    Hussain, N.; Salimi, P.

    2014-01-01

    The notion of modular metric spaces being a natural generalization of classical modulars over linear spaces like Lebesgue, Orlicz, Musielak-Orlicz, Lorentz, Orlicz-Lorentz, and Calderon-Lozanovskii spaces was recently introduced. In this paper we investigate the existence of fixed points of generalized α-admissible modular contractive mappings in modular metric spaces. As applications, we derive some new fixed point theorems in partially ordered modular metric spaces, Suzuki type fixed point theorems in modular metric spaces and new fixed point theorems for integral contractions. In last section, we develop an important relation between fuzzy metric and modular metric and deduce certain new fixed point results in triangular fuzzy metric spaces. Moreover, some examples are provided here to illustrate the usability of the obtained results. PMID:25003157

  3. [Effect of Three Typical Disinfection Byproducts on Bacterial Antibiotic Resistance].

    PubMed

    Lü, Lu; Zhang, Meng-lu; Wang, Chun-ming; Lin, Hui-rong; Yu, Xin

    2015-07-01

    The effect of typical disinfection byproducts (DBPs) on bacterial antibiotic resistance was investigated in this study. chlorodibromomethane (CDBM), iodoacetic acid (IAA) and chloral hydrate (CH) were selected, which belong to trihalomethanes (THMs), haloacetic acids (HAAs) and aldehydes, respectively. After exposure to the selected DBPs, the resistance change of the tested strains to antibiotics was determined. As a result, all of the three DBPs induced Pseudomonas aeruginosa PAO1 to gain increased resistance to the five antibiotics tested, and the DBPs ranked as IAA > CH > CDBM according to their enhancement effects. Multidrug resistance could also be enhanced by treatment with IAA. The same result was observed in Escherichia coli K12, suggesting that the effect of DBPs on antibiotic resistance was a common phenomenon. The mechanism was probably that DBPs stimulated oxidative stress, which induced mutagenesis. And the antibiotic resistance mutation frequency could be increased along with mutagenesis. This study revealed that the acquisition of bacterial antibiotic resistance might be related to DBPs in drinking water systems. Besides the genotoxicological risks, the epidemiological risks of DBPs should not be overlooked.

  4. Metric Measures and the Consumer. Reprint from FDA CONSUMER, Dec. 1975-Jan. 1976.

    ERIC Educational Resources Information Center

    Food and Drug Administration (DHEW), Washington, DC.

    Advantages of the metric system for the consumer are discussed. Basic metric units are described, then methods of comparison shopping when items are marked in metric units are explained. The effect of the change to the metric system on packaging and labelling requirements is discussed. (DT)

  5. Random Kähler metrics

    NASA Astrophysics Data System (ADS)

    Ferrari, Frank; Klevtsov, Semyon; Zelditch, Steve

    2013-04-01

    The purpose of this article is to propose a new method to define and calculate path integrals over metrics on a Kähler manifold. The main idea is to use finite dimensional spaces of Bergman metrics, as an approximation to the full space of Kähler metrics. We use the theory of large deviations to decide when a sequence of probability measures on the spaces of Bergman metrics tends to a limit measure on the space of all Kähler metrics. Several examples are considered.

  6. Effect of heat leaks in platinum resistance thermometry.

    PubMed

    Goldratt, E; Yeshurun, Y; Greenfield, A J

    1980-03-01

    The effect of heat leaks in platinum resistance thermometry is analyzed. An experimental method is proposed for estimating the magnitude of this effect. Results are reported for the measurement of the temperature of a hot, solid body under different heat-leak configurations. Design criteria for thermometers are presented which minimize the effect of such heat leaks.

  7. Effect of heat leaks in platinum resistance thermometry

    NASA Astrophysics Data System (ADS)

    Goldratt, E.; Yeshurun, Y.; Greenfield, A. J.

    1980-03-01

    The effect of heat leaks in platinum resistance thermometry is analyzed. An experimental method is proposed for estimating the magnitude of this effect. Results are reported for the measurement of the temperature of a hot, solid body under different heat-leak configurations. Design criteria for thermometers are presented which minimize the effect of such heat leaks.

  8. Optical metrics and projective equivalence

    SciTech Connect

    Casey, Stephen; Dunajski, Maciej; Gibbons, Gary; Warnick, Claude

    2011-04-15

    Trajectories of light rays in a static spacetime are described by unparametrized geodesics of the Riemannian optical metric associated with the Lorentzian spacetime metric. We investigate the uniqueness of this structure and demonstrate that two different observers, moving relative to one another, who both see the Universe as static may determine the geometry of the light rays differently. More specifically, we classify Lorentzian metrics admitting more than one hyper-surface orthogonal timelike Killing vector and analyze the projective equivalence of the resulting optical metrics. These metrics are shown to be projectively equivalent up to diffeomorphism if the static Killing vectors generate a group SL(2,R), but not projectively equivalent in general. We also consider the cosmological C metrics in Einstein-Maxwell theory and demonstrate that optical metrics corresponding to different values of the cosmological constant are projectively equivalent.

  9. Effect of mechanical surface and heat treatments on erosion resistance

    NASA Technical Reports Server (NTRS)

    Salik, J.; Buckley, D. H.

    1980-01-01

    The effects of mechanical surface treatments as well as heat treatments on the erosion resistance of 6061 aluminum alloy and 1045 steel were studied. Mechanical surface treatments were found to have little or no effect on the erosion resistance. This is due to the formation by particle impact of a work hardened surface layer regardless of the initial surface condition. The erosion resistance of Al single crystals is found to be independent of orientation. This is due to destruction of the surface microstructure and formation of a polycrystalline surface layer by the impact of erodant particles as observed by X-ray diffraction. While upon solution treatment of annealed 6061 aluminum the increase in hardness is accompanied by an increase in erosion resistance, precipitation treatment which causes a further increase in hardness results in slightly lower erosion resistance. Using two types of erodant particles, glass beads and crushed glass, the erosion rate is found to be strongly dependent on erodant particle shape, being an order of magnitude higher for erosion with crushed glass as compared to glass beads. While for erosion with glass beads heat treatment of 1045 steel had a profound effect on its erosion resistance, little or no such effect was observed for erosion with crushed glass.

  10. Effect of curative parathyroidectomy on insulin resistance

    PubMed Central

    Putnam, Rachel; Dhibar, Deba Prasad; Varshney, Shweta; Behera, Arunanshu; Mittal, B. R.; Bhansali, Anil; Rao, Sudhaker D.; Bhadada, Sanjay Kumar

    2016-01-01

    Background: Primary hyperparathyroidism (PHPT) is characterized by inappropriately elevated serum parathyroid hormone (PTH) level despite elevated serum calcium. Insulin resistant is the basic pathophysiology, behind the higher prevalence of diabetes mellitus in patients with PHPT. However, the improvement in insulin resistance (IR) after curative parathyroidectomy (CPTX) has not been established yet, as the study results are conflicting. Materials and Methods: In this prospective interventional study, ten patients with mild PHPT (Group 1) and another ten patients with moderate to severe PHPT (Group 2) were undergone CPTX. The IR was assessed by homeostasis model assessment-IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), and fasting serum insulin (FSI), before and 3 months after CPTX. Results: There was no significant change of FPG and FSI, before and after CPTX in Group 1 (P = 0.179 and P = 0.104) and Group 2 (P = 0.376 and P = 0.488). Before surgery, HOMA-IR was higher, and QUICKI was significantly lower, in both Group 1 (P = 0.058 and P = 0.009) and Group 2 (P = 0.023 and P = 0.005) as compared to published normal reference mean, with no significant difference between the groups. Three months after surgery HOMA-IR increased further and QUICKI remained unchanged as compared to baseline, in both Group 1 (P = 0.072 and 0.082) and Group 2 (P = 0.54 and 0.56), but statistically insignificant. Conclusion: IR remained unchanged after CPTX in mild as well as moderate to severe PHPT. Asymptomatic PHPT with abnormal IR should not be used as criteria for parathyroidectomy. PMID:27867880

  11. Validating Software Metrics

    DTIC Science & Technology

    1990-09-30

    validation test: Spearman Rank Correlation and Wald - Wolfowitz Runs Test (test for randomness) (5,8]. For example, if a complexity metric is claimed to be... error count (E). Validity Criteria Select values of V, B, A, and P. The values of V, B, A, and P, used in the example are .7, .7, 20%, and 80...Procedures with no errors Average rank of first group = 85.2419 based on 31 values . Average rank of second group = 45.5 based on 81 values . Large sample test

  12. SI (Metric) handbook

    NASA Astrophysics Data System (ADS)

    Artusa, Elisa A.

    1994-03-01

    This guide provides information for an understanding of SI units, symbols, and prefixes; style and usage in documentation in both the US and in the international business community; conversion techniques; limits, fits, and tolerance data; and drawing and technical writing guidelines. Also provided is information of SI usage for specialized applications like data processing and computer programming, science, engineering, and construction. Related information in the appendixes include legislative documents, historical and biographical data, a list of metric documentation, rules for determining significant digits and rounding, conversion factors, shorthand notation, and a unit index.

  13. SI (Metric) handbook

    NASA Technical Reports Server (NTRS)

    Artusa, Elisa A.

    1994-01-01

    This guide provides information for an understanding of SI units, symbols, and prefixes; style and usage in documentation in both the US and in the international business community; conversion techniques; limits, fits, and tolerance data; and drawing and technical writing guidelines. Also provided is information of SI usage for specialized applications like data processing and computer programming, science, engineering, and construction. Related information in the appendixes include legislative documents, historical and biographical data, a list of metric documentation, rules for determining significant digits and rounding, conversion factors, shorthand notation, and a unit index.

  14. Comparing Resource Adequacy Metrics

    SciTech Connect

    Ibanez, Eduardo; Milligan, Michael

    2014-11-13

    As the penetration of variable generation (wind and solar) increases around the world, there is an accompanying growing interest and importance in accurately assessing the contribution that these resources can make toward planning reserve. This contribution, also known as the capacity credit or capacity value of the resource, is best quantified by using a probabilistic measure of overall resource adequacy. In recognizing the variable nature of these renewable resources, there has been interest in exploring the use of reliability metrics other than loss of load expectation. In this paper, we undertake some comparisons using data from the Western Electricity Coordinating Council in the western United States.

  15. Sustainable chemistry metrics.

    PubMed

    Calvo-Flores, Francisco García

    2009-01-01

    Green chemistry has developed mathematical parameters to describe the sustainability of chemical reactions and processes, in order to quantify their environmental impact. These parameters are related to mass and energy magnitudes, and enable analyses and numerical diagnoses of chemical reactions. The environmental impact factor (E factor), atom economy, and reaction mass efficiency have been the most influential metrics, and they are interconnected by mathematical equations. The ecodesign concept must also be considered for complex industrial syntheses, as a part of the sustainability of manufacturing processes. The aim of this Concept article is to identify the main parameters for evaluating undesirable environmental consequences.

  16. Effect of the eccentricity of normal resistivity borehole tools on the current field and resistivity measurement

    NASA Astrophysics Data System (ADS)

    Galsa, Attila; Herein, Mátyás; Drahos, Dezső; Herein, András

    2016-11-01

    Three-dimensional finite element numerical model calculations have been carried out to investigate the quantitative effect of the eccentric position of a normal resistivity borehole probe used in practice. Detailed calculations were done between the point-wise analytical solution and numerical solution to verify the results obtained from the finite element method for a normal probe with finite-length cylindrical electrodes. In the borehole the pattern of the current flowing out from current electrode A is efficiently influenced by the eccentricity. For high-resistivity rock the current density is decreased, while for low-resistivity rock it is increased toward the wall side. On the other hand, the eccentricity does not affect considerably the apparent resistivity calculated from electrode potentials. In most geological situations the deviation is less than 2%. However, in infrequent cases when the true resistivity of the rock is extremely low and/or the distance between the potential and current electrodes is very small the effect of the eccentricity can exceed even 10%.

  17. Early Warning Look Ahead Metrics: The Percent Milestone Backlog Metric

    NASA Technical Reports Server (NTRS)

    Shinn, Stephen A.; Anderson, Timothy P.

    2017-01-01

    All complex development projects experience delays and corresponding backlogs of their project control milestones during their acquisition lifecycles. NASA Goddard Space Flight Center (GSFC) Flight Projects Directorate (FPD) teamed with The Aerospace Corporation (Aerospace) to develop a collection of Early Warning Look Ahead metrics that would provide GSFC leadership with some independent indication of the programmatic health of GSFC flight projects. As part of the collection of Early Warning Look Ahead metrics, the Percent Milestone Backlog metric is particularly revealing, and has utility as a stand-alone execution performance monitoring tool. This paper describes the purpose, development methodology, and utility of the Percent Milestone Backlog metric. The other four Early Warning Look Ahead metrics are also briefly discussed. Finally, an example of the use of the Percent Milestone Backlog metric in providing actionable insight is described, along with examples of its potential use in other commodities.

  18. Relating reconnection rate, exhaust structure and effective resistivity

    NASA Astrophysics Data System (ADS)

    Singh, Nagendra

    2014-03-01

    The magnetic reconnection structure consists of a central diffusion region (CDR) and a cone or wedge shaped reconnection exhaust containing accelerated plasma flows and electromagnetic fluctuations. We predict here the relationship among the exhaust half-cone angle (θe), the half width (w) of the CDR, the outflow velocity Vo, and the effective resistivity (ηeff), which includes the effects of all the nonideal terms in the generalized Ohm's law. The effective resistivity is defined as the ratio of reconnection electric field Erec to the current density Jy at the X point and it essentially represents the loss of momentum from the current-carrying plasma particles due to scattering by waves, their inertia or outflux from the CDR. The relation is checked against relevant results previously reported from laboratory experiments, space observations, and simulations, showing excellent agreement. The relation can be used for estimating the ad-hoc effective resistivity often used in magnetohydrodynamic modeling of reconnection.

  19. Oral antibiotics are effective for highly resistant hip arthroplasty infections.

    PubMed

    Cordero-Ampuero, José; Esteban, Jaime; García-Cimbrelo, Eduardo

    2009-09-01

    Infected arthroplasties reportedly have a lower eradication rate when caused by highly resistant and/or polymicrobial isolates and in these patients most authors recommend intravenous antibiotics. We asked whether two-stage revision with interim oral antibiotics could eradicate these infections. We prospectively followed 36 patients (mean age, 71.8 years) with late hip arthroplasty infections. Combinations of oral antibiotics were prescribed according to cultures, biofilm, and intracellular effectiveness. The minimum followup was 1 year (mean, 4.4 years; range, 1-12 years). We presumed eradication in the absence of clinical, serologic, and radiographic signs of infection. Infection was eradicated in all 13 patients with highly resistant bacteria who completed a two-stage protocol (10 with methicillin-resistant Staphylococci) and in eight of 11 patients treated with only the first stage (and six of nine with methicillin-resistant Staphylococci). Infection was eradicated in six of six patients with polymicrobial isolates (of sensitive and/or resistant bacteria) who completed a two-stage protocol and in five of seven with polymicrobial isolates treated with only the first surgery. The Harris hip score averaged 88.1 (range, 70-98) in patients who underwent reimplantation and 56.8 (range, 32-76) in patients who underwent resection arthroplasty. Long cycles of combined oral antibiotics plus a two-stage surgical exchange appear a promising alternative for infections by highly resistant bacteria, methicillin-resistant Staphylococci, and polymicrobial infections.

  20. Short Lived Climate Pollutants cause a Long Lived Effect on Sea-level Rise: Analyzing climate metrics for sea-level rise

    NASA Astrophysics Data System (ADS)

    Sterner, E.; Johansson, D. J.

    2013-12-01

    Climate change depends on the increase of several different atmospheric pollutants. While long term global warming will be determined mainly by carbon dioxide, warming in the next few decades will depend to a large extent on short lived climate pollutants (SLCP). Reducing emissions of SLCPs could contribute to lower the global mean surface temperature by 0.5 °C already by 2050 (Shindell et al. 2012). Furthermore, the warming effect of one of the most potent SLCPs, black carbon (BC), may have been underestimated in the past. Bond et al. (2013) presents a new best estimate of the total BC radiative forcing (RF) of 1.1 W/m2 (90 % uncertainty bounds of 0.17 to 2.1 W/m2) since the beginning of the industrial era. BC is however never emitted alone and cooling aerosols from the same sources offset a majority of this RF. In the wake of calls for mitigation of SLCPs it is important to study other aspects of the climate effect of SLCPs. One key impact of climate change is sea-level rise (SLR). In a recent study, the effect of SLCP mitigation scenarios on SLR is examined. Hu et al (2013) find a substantial effect on SLR from mitigating SLCPs sharply, reducing SLR by 22-42% by 2100. We choose a different approach focusing on emission pulses and analyse a metric based on sea level rise so as to further enlighten the SLR consequences of SLCPs. We want in particular to understand the time dynamics of SLR impacts caused by SLCPs compared to other greenhouse gases. The most commonly used physical based metrics are GWP and GTP. We propose and evaluate an additional metric: The global sea-level rise potential (GSP). The GSP is defined as the sea level rise after a time horizon caused by an emissions pulse of a forcer to the sea level rise after a time horizon caused by an emissions pulse of a CO2. GSP is evaluated and compared to GWP and GTP using a set of climate forcers chosen to cover the whole scale of atmospheric perturbation life times (BC, CH4, N2O, CO2 and SF6). The study

  1. Effects of Raltegravir or Elvitegravir Resistance Signature Mutations on the Barrier to Dolutegravir Resistance In Vitro

    PubMed Central

    Seki, Takahiro; Suyama-Kagitani, Akemi; Kawauchi-Miki, Shinobu; Miki, Shigeru; Wakasa-Morimoto, Chiaki; Akihisa, Erika; Nakahara, Koichiro; Kobayashi, Masanori; Underwood, Mark R.; Sato, Akihiko; Fujiwara, Tamio

    2015-01-01

    The recently approved HIV-1 integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) (S/GSK1349572) has overall advantageous activity when tested in vitro against HIV-1 with raltegravir (RAL) and elvitegravir (EVG) resistance signature mutations. We conducted an in vitro resistance selection study using wild-type HIV-1 and mutants with the E92Q, Y143C, Y143R, Q148H, Q148K, Q148R, and N155H substitutions to assess the DTG in vitro barrier to resistance. No viral replication was observed at concentrations of ≥32 nM DTG, whereas viral replication was observed at 160 nM RAL or EVG in the mutants. In the Q148H, Q148K, or Q148R mutants, G140S/Q148H, E138K/Q148K, E138K/Q148R, and G140S/Q148R secondary mutations were identified with each INSTI and showed high resistance to RAL or EVG but limited resistance to DTG. E138K and G140S, as secondary substitutions to Q148H, Q148K, or Q148R, were associated with partial recovery in viral infectivity and/or INSTI resistance. In the E92Q, Y143C, Y143R, and N155H mutants, no secondary substitutions were associated with DTG. These in vitro results suggest that DTG has a high barrier to the development of resistance in the presence of RAL or EVG signature mutations other than Q148. One explanation for this high barrier to resistance is that no additional secondary substitution of E92Q, Y143C, Y143R, or N155H simultaneously increased the fold change in 50% effective concentration (EC50) to DTG and infectivity. Although increased DTG resistance via the Q148 pathway and secondary substitutions occurs at low concentrations, a higher starting concentration may reduce or eliminate the development of DTG resistance in this pathway in vitro. PMID:25691633

  2. Predicting the acute behavioral effects in rats inhaling toluene (or up to 24 hrs: Inhaled vs. internal dose metrics.

    EPA Science Inventory

    The acute toxicity oftoluene, a model volatile organic compound (VOC), depends on the concentration (C) and duration (t) ofexposure, and guidelines for acute exposures have traditionally used ext relationships to extrapolate protective and/or effective concentrations across durat...

  3. Effect Sizes for Growth-Modeling Analysis for Controlled Clinical Trials in the Same Metric as for Classical Analysis

    PubMed Central

    Feingold, Alan

    2009-01-01

    The use of growth-modeling analysis (GMA)--including Hierarchical Linear Models, Latent Growth Models, and General Estimating Equations--to evaluate interventions in psychology, psychiatry, and prevention science has grown rapidly over the last decade. However, an effect size associated with the difference between the trajectories of the intervention and control groups that captures the treatment effect is rarely reported. This article first reviews two classes of formulas for effect sizes associated with classical repeated-measures designs that use the standard deviation of either change scores or raw scores for the denominator. It then broadens the scope to subsume GMA, and demonstrates that the independent groups, within-subjects, pretest-posttest control-group, and GMA designs all estimate the same effect size when the standard deviation of raw scores is uniformly used. Finally, it is shown that the correct effect size for treatment efficacy in GMA--the difference between the estimated means of the two groups at end of study (determined from the coefficient for the slope difference and length of study) divided by the baseline standard deviation--is not reported in clinical trials. PMID:19271847

  4. Origins of effective resistivity in collisionless magnetic reconnection

    NASA Astrophysics Data System (ADS)

    Singh, Nagendra

    2014-07-01

    The mechanisms that provide effective resistivity for supporting collisonless magnetic reconnection have remained unsettled despite numerous studies. Some of these studies demonstrated that the electron pressure nongyrotropy generates the resistivity (ηnpg) in the electron diffusion region (EDR). We derive an analytical relation for the effective resistivity (ηkin) by momentum balance in a control volume in the EDR. Both ηnpg and ηkin mutually compare well and they also compare well with the resistivity required to support reconnection electric field Erec in multi-dimensional particle-in-cell simulations as well as in satellite observations when reconnection occurs in an EDR. But they are about an order of magnitude or so smaller than that required when the reconnection occurred in a much wider reconnecting current sheet (RCS) of half width (w) of the order of the ion skin depth (di), observed in the Earth magnetosphere. The chaos-induced resistivity reported in the literature is found to be even more deficient. We find that for reconnection in RCS with w ˜ di, anomalous diffusion, such as the universal Bhom diffusion and/or that arising from kinetic Alfven waves, could fairly well account for the required resistivity.

  5. Origins of effective resistivity in collisionless magnetic reconnection

    SciTech Connect

    Singh, Nagendra

    2014-07-15

    The mechanisms that provide effective resistivity for supporting collisonless magnetic reconnection have remained unsettled despite numerous studies. Some of these studies demonstrated that the electron pressure nongyrotropy generates the resistivity (η{sub npg}) in the electron diffusion region (EDR). We derive an analytical relation for the effective resistivity (η{sub kin}) by momentum balance in a control volume in the EDR. Both η{sub npg} and η{sub kin} mutually compare well and they also compare well with the resistivity required to support reconnection electric field E{sub rec} in multi-dimensional particle-in-cell simulations as well as in satellite observations when reconnection occurs in an EDR. But they are about an order of magnitude or so smaller than that required when the reconnection occurred in a much wider reconnecting current sheet (RCS) of half width (w) of the order of the ion skin depth (d{sub i}), observed in the Earth magnetosphere. The chaos-induced resistivity reported in the literature is found to be even more deficient. We find that for reconnection in RCS with w ∼ d{sub i}, anomalous diffusion, such as the universal Bhom diffusion and/or that arising from kinetic Alfven waves, could fairly well account for the required resistivity.

  6. The Warburg effect and drug resistance

    PubMed Central

    Mohd Omar, Mohd Feroz; Soong, Richie

    2016-01-01

      The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently, studies have begun to reveal how the Warburg effect could influence drug efficacy and how our understanding of tumour energetics could be exploited to improve drug development. In particular, evidence is emerging demonstrating how better modelling of the tumour metabolic microenvironment could lead to a better prediction of drug efficacy and the identification of new combination strategies. This review will provide details of the current understanding of the complex interplay between glucose metabolism and pharmacology and discuss opportunities for utilizing the Warburg effect in future drug development. PMID:26750865

  7. Effect Sizes for Growth-Modeling Analysis for Controlled Clinical Trials in the Same Metric as for Classical Analysis

    ERIC Educational Resources Information Center

    Feingold, Alan

    2009-01-01

    The use of growth-modeling analysis (GMA)--including hierarchical linear models, latent growth models, and general estimating equations--to evaluate interventions in psychology, psychiatry, and prevention science has grown rapidly over the last decade. However, an effect size associated with the difference between the trajectories of the…

  8. PREDICTING THE ACUTE BEHAVIORAL EFFECTS OF TOLUENE INHALED FOR 24 HRS IN RATS: DOSE METRICS, METABOLISM AND BEHAVIORAL TOLERANCE

    EPA Science Inventory

    Purpose: Recent research on the acute effects of volatile organic compounds (VOCs) suggests that extrapolation from short (~ 1 h) to long durations (up to 4 h) is improved by using estimates of brain toluene concentration ( Br[ToI)] instead of cumulative inhaled dose (C x t) as a...

  9. Vestibular influence on auditory metrical interpretation.

    PubMed

    Phillips-Silver, Jessica; Trainor, Laurel J

    2008-06-01

    When we move to music we feel the beat, and this feeling can shape the sound we hear. Previous studies have shown that when people listen to a metrically ambiguous rhythm pattern, moving the body on a certain beat--adults, by actively bouncing themselves in synchrony with the experimenter, and babies, by being bounced passively in the experimenter's arms--can bias their auditory metrical representation so that they interpret the pattern in a corresponding metrical form [Phillips-Silver, J., & Trainor, L. J. (2005). Feeling the beat: Movement influences infant rhythm perception. Science, 308, 1430; Phillips-Silver, J., & Trainor, L. J. (2007). Hearing what the body feels: Auditory encoding of rhythmic movement. Cognition, 105, 533-546]. The present studies show that in adults, as well as in infants, metrical encoding of rhythm can be biased by passive motion. Furthermore, because movement of the head alone affected auditory encoding whereas movement of the legs alone did not, we propose that vestibular input may play a key role in the effect of movement on auditory rhythm processing. We discuss possible cortical and subcortical sites for the integration of auditory and vestibular inputs that may underlie the interaction between movement and auditory metrical rhythm perception.

  10. Cleanroom Energy Efficiency: Metrics and Benchmarks

    SciTech Connect

    International SEMATECH Manufacturing Initiative; Mathew, Paul A.; Tschudi, William; Sartor, Dale; Beasley, James

    2010-07-07

    Cleanrooms are among the most energy-intensive types of facilities. This is primarily due to the cleanliness requirements that result in high airflow rates and system static pressures, as well as process requirements that result in high cooling loads. Various studies have shown that there is a wide range of cleanroom energy efficiencies and that facility managers may not be aware of how energy efficient their cleanroom facility can be relative to other cleanroom facilities with the same cleanliness requirements. Metrics and benchmarks are an effective way to compare one facility to another and to track the performance of a given facility over time. This article presents the key metrics and benchmarks that facility managers can use to assess, track, and manage their cleanroom energy efficiency or to set energy efficiency targets for new construction. These include system-level metrics such as air change rates, air handling W/cfm, and filter pressure drops. Operational data are presented from over 20 different cleanrooms that were benchmarked with these metrics and that are part of the cleanroom benchmark dataset maintained by Lawrence Berkeley National Laboratory (LBNL). Overall production efficiency metrics for cleanrooms in 28 semiconductor manufacturing facilities in the United States and recorded in the Fabs21 database are also presented.

  11. Effects of sleeve gastrectomy on insulin resistance

    PubMed Central

    CĂTOI, ADRIANA FLORINELA; PÂRVU, ALINA; MIRONIUC, AUREL; GALEA, ROMEO FLORIN; MUREŞAN, ADRIANA; BIDIAN, CRISTINA; POP, IOANA

    2016-01-01

    Background and aim Obesity is a major risk factor for the onset of insulin resistance (IR), hyperinsulinemia and type 2 diabetes mellitus (T2DM) Evidence data has proven that beyond important weight loss bariatric surgery especially Roux-en-Y gastric bypass (RYGB) and bilio-pancreatic diversion (BPD) leads to significant early reduction of insulinemia and of IR calculated through the homeostatic model assessment (HOMA-IR), independently of fat mass decrease. Sleeve gastrectomy (SG) is now used as a sole weight loss operation with good results. Therefore, the aim of the present study was to investigate the early changes of fasting blood glucose, insulin and HOMA-IR in a group of morbidly obese (MO) patients i.e. at 7, 30 and 90 days after SG. Methods The study included 20 MO patients (7 male and 13 female) submitted to SG. Anthropometrical (weight, body mass index –BMI, percent excess BMI loss -%EBMIL) and biochemical (plasma glucose, insulin and calculated HOMA-IR ) evaluation were performed before and at 7, 30 and 90 days after SG. In addition, a second group of 10 normal weight healthy subjects with a BMI ranging form 19 kg/m2 to 23.14 kg/m2, matched for age and gender was investigated. Results Plasma glucose (p=0.018), insulin (p=0.004) and HOMA-IR (p=0.006) values were statistically different between the studied groups. After surgery, at every follow-up point, there were statistically different weight and BMI mean values relative to the operation day (p<0.003). BMI, decreased at 7 days (estimated reduction=2.79; 95% CI:[2.12;3.45]), at 30 days (estimated reduction=5.65; 95% CI:[3.57;7.73]) and at 90 days (estimated reduction=10.88; 95% CI:[7.35;14.41]) respectively after SG. We noted a tendency toward statistical significant change of mean insulin values at 7 days after surgery (corrected p=0.075), no statistical change at 30 days (corrected p=0.327) and a significant change at 90 days (corrected p=0.027) after SG as compared to baseline. There was a

  12. Tissue concentrations as the dose metric to assess potential toxic effects of metals in field-collected fish: Copper and cadmium.

    PubMed

    Meador, James P

    2015-06-01

    The present study examined the available literature linking whole-body tissue concentrations with toxic effects in fish species for copper and cadmium. The variability in effect concentration for both copper and cadmium among species occurred within an order of magnitude for all responses, whereas the range for lethal toxicity based on water exposure spanned approximately 4 to 5 orders of magnitude. Fish tissue concentrations causing adverse effects were just above background concentrations, occurring between 1 μg/g and 10 μg/g for copper and 0.1 μg/g to 4 μg/g for cadmium. The results also show that salmonids are especially sensitive to cadmium, which appears to be a function of chemical potency. No studies were found that indicated adverse effects without increases in whole-body concentration of these metals. This narrow range for dose-response implies that a toxicological spillover point occurs when the detoxification capacity of various tissues within the animal are exceeded, and this likely occurs at a similar whole-body concentration for all naïvely exposed fish species. Elevated whole-body concentrations in fish from the field may be indicative of possible acclimation to metals that may or may not result in effects for target species. Acclimation concentrations may be useful in that they signal excessive metal concentrations in water, sediment, or prey species for a given site and indicate likely toxic effects for species unable to acclimate to excess metal exposure. Using tissue residues as the dose metric for these metals provides another line of evidence for assessing impaired ecosystems and greater confidence that hazard concentrations are protective for all fish species.

  13. Landscape pattern metrics and regional assessment

    USGS Publications Warehouse

    O'Neill, R. V.; Riitters, K.H.; Wickham, J.D.; Jones, K.B.

    1999-01-01

    The combination of remote imagery data, geographic information systems software, and landscape ecology theory provides a unique basis for monitoring and assessing large-scale ecological systems. The unique feature of the work has been the need to develop and interpret quantitative measures of spatial pattern-the landscape indices. This article reviews what is known about the statistical properties of these pattern metrics and suggests some additional metrics based on island biogeography, percolation theory, hierarchy theory, and economic geography. Assessment applications of this approach have required interpreting the pattern metrics in terms of specific environmental endpoints, such as wildlife and water quality, and research into how to represent synergystic effects of many overlapping sources of stress.

  14. How inaccurate is weight as a metric for patient size? Comparing patient weight to effective diameter for size-specific dose estimation

    NASA Astrophysics Data System (ADS)

    Cook, Tessa S.; Chadalavada, Seetharam C.; Boonn, William W.

    2013-03-01

    One of the biggest challenges in dose monitoring is customization of CT dose estimates to the patient. Patient size remains a highly significant variable. One metric that has previously been used for patient size is patient weight, though this is often criticized as inaccurate. In this work, we compare patients' weight to their effective diameters obtained from a CT scan of the chest or the abdomen. CT exams of the chest (N=163) and abdomen/pelvis (N=168) performed on adult patients in July 2012 were randomly selected for analysis. The effective diameter of the patient for each exam was determined using the central slice of the scan region for each exam using eXposure™ (Radimetrics, Inc., Toronto, Canada). In some cases, the same patient had both a chest and abdominopelvic CT, so effective diameters from both regions were analyzed. In this small sample size, there appears to be a linear relationship between patient weight and effective diameter when measured in the mid-chest and mid-abdomen of adult patients. However, for each weight, patient effective diameter can vary by 5 cm from the regression line in both the chest and the abdomen. A 5-cm difference corresponds to a difference of approximately 0.2 in the chest and 0.3 in the abdomen/pelvis for the correction factors recommended for size-specific dose estimation by the AAPM. This preliminary data suggests that weight-based CT protocoling may in fact be appropriate for some adults. However, more work is needed to identify those patients in whom weight-based protocoling is not appropriate.

  15. Implementing the Metric System in Agricultural Occupations. Metric Implementation Guide.

    ERIC Educational Resources Information Center

    Gilmore, Hal M.; And Others

    Addressed to the agricultural education teacher, this guide is intended to provide appropriate information, viewpoints, and attitudes regarding the metric system and to make suggestions regarding presentation of the material in the classroom. An introductory section on teaching suggestions emphasizes the need for a "think metric" approach made up…

  16. Implementing the Metric System in Health Occupations. Metric Implementation Guide.

    ERIC Educational Resources Information Center

    Banks, Wilson P.; And Others

    Addressed to the health occupations education teacher, this guide is intended to provide appropriate information, viewpoints, and attitudes regarding the metric system and to make suggestions regarding presentation of the material in the classroom. An introductory section on teaching suggestions emphasizes the need for a "think metric" approach…

  17. Implementing the Metric System in Business Occupations. Metric Implementation Guide.

    ERIC Educational Resources Information Center

    Retzer, Kenneth A.; And Others

    Addressed to the business education teacher, this guide is intended to provide appropriate information, viewpoints, and attitudes regarding the metric system and to make suggestions regarding presentation of the material in the classroom. An introductory section on teaching suggestions emphasizes the need for a "think metric" approach made up of…

  18. Implementing the Metric System in Industrial Occupations. Metric Implementation Guide.

    ERIC Educational Resources Information Center

    Retzer, Kenneth A.

    Addressed to the industrial education teacher, this guide is intended to provide appropriate information, viewpoints, and attitudes regarding the metric system and to make suggestions regarding presentation of the material in the classroom. An introductory section on teaching suggestions emphasizes the need for a "think metric" approach made up of…

  19. Software metrics: Software quality metrics for distributed systems. [reliability engineering

    NASA Technical Reports Server (NTRS)

    Post, J. V.

    1981-01-01

    Software quality metrics was extended to cover distributed computer systems. Emphasis is placed on studying embedded computer systems and on viewing them within a system life cycle. The hierarchy of quality factors, criteria, and metrics was maintained. New software quality factors were added, including survivability, expandability, and evolvability.

  20. Resistance training is medicine: effects of strength training on health.

    PubMed

    Westcott, Wayne L

    2012-01-01

    Inactive adults experience a 3% to 8% loss of muscle mass per decade, accompanied by resting metabolic rate reduction and fat accumulation. Ten weeks of resistance training may increase lean weight by 1.4 kg, increase resting metabolic rate by 7%, and reduce fat weight by 1.8 kg. Benefits of resistance training include improved physical performance, movement control, walking speed, functional independence, cognitive abilities, and self-esteem. Resistance training may assist prevention and management of type 2 diabetes by decreasing visceral fat, reducing HbA1c, increasing the density of glucose transporter type 4, and improving insulin sensitivity. Resistance training may enhance cardiovascular health, by reducing resting blood pressure, decreasing low-density lipoprotein cholesterol and triglycerides, and increasing high-density lipoprotein cholesterol. Resistance training may promote bone development, with studies showing 1% to 3% increase in bone mineral density. Resistance training may be effective for reducing low back pain and easing discomfort associated with arthritis and fibromyalgia and has been shown to reverse specific aging factors in skeletal muscle.

  1. [Reversing effects of emodin on multidrug resistance in resistant HL-60/ADR cells].

    PubMed

    Chen, Ying-Yu; Li, Jing; Hu, Jian-Da; Zheng, Jing; Zheng, Zhi-Hong; Zhu, Liang-Fang; Chen, Xin-Ji; Lin, Zhen-Xing

    2013-12-01

    This study was aimed to investigate the reversing effects of emodin on multidrug resistance (MDR) in resistant HL-60/ADR cells, and to explore the underlying mechanisms. The MTT assay was used to assess the chemoresistance of HL-60/ADR cells to emodin and 8 chemotherapeutic agents commonly used in clinic. The reversal effects of emodin on MDR of HL-60/ADR cells were also evaluated by MTT method. DNA ploidy analysis and DNA Ladder assay were used to detect apoptosis-induced effects on HL-60/ADR cells via the adriamycin (ADR) and emodin combination. The expression changes of the drug resistance-associated genes and proteins were detected by RT-PCR and Western Blot respectively. The intracellular accumulation and subcellular distribution of ADR and DNR were measured by flow cytometry and confocal laser scanning microscopy. The results showed that emodin inhibited HL-60/ADR cell proliferation with an average IC50 value of 24.09 ± 1.72 µmol/L, which was similar to that of the parental HL-60 cells (average IC50 = 23.18 ± 0.87 µmol/L). HL-60/ADR cells were resistant to a variety of chemotherapeutic agents, such as ADR, DNR, VP16, VCR,Ara-C, HHT, MTZ and THP. The reversal multiple were between 1.58 and 4.12 after the treatment with low concentration of emodin combined with the above mentioned different agents. The combination of ADR with emodin showed the best reversal effects, and the typical hypodiploid peak (apoptotic peak) and DNA ladder could be detected after the co-treatment.In addition, emodin down-regulated the mRNA and protein expression levels of MRP1, TOPOIIβ, GST π and BCL-2. Furthermore, the addition of emodin enhanced ADR and DNR intracellular accumulation and subcellular distribution in HL-60/ADR cells in dose-dependent manner. It is concluded that the emodin shows reversing effects on the multidrug resistant HL-60/ADR cells, possibly via decreasing the expression levels of drug resistance-associated genes, increasing the intracellular accumulation of

  2. Measurable Control System Security through Ideal Driven Technical Metrics

    SciTech Connect

    Miles McQueen; Wayne Boyer; Sean McBride; Marie Farrar; Zachary Tudor

    2008-01-01

    The Department of Homeland Security National Cyber Security Division supported development of a small set of security ideals as a framework to establish measurable control systems security. Based on these ideals, a draft set of proposed technical metrics was developed to allow control systems owner-operators to track improvements or degradations in their individual control systems security posture. The technical metrics development effort included review and evaluation of over thirty metrics-related documents. On the bases of complexity, ambiguity, or misleading and distorting effects the metrics identified during the reviews were determined to be weaker than necessary to aid defense against the myriad threats posed by cyber-terrorism to human safety, as well as to economic prosperity. Using the results of our metrics review and the set of security ideals as a starting point for metrics development, we identified thirteen potential technical metrics - with at least one metric supporting each ideal. Two case study applications of the ideals and thirteen metrics to control systems were then performed to establish potential difficulties in applying both the ideals and the metrics. The case studies resulted in no changes to the ideals, and only a few deletions and refinements to the thirteen potential metrics. This led to a final proposed set of ten core technical metrics. To further validate the security ideals, the modifications made to the original thirteen potential metrics, and the final proposed set of ten core metrics, seven separate control systems security assessments performed over the past three years were reviewed for findings and recommended mitigations. These findings and mitigations were then mapped to the security ideals and metrics to assess gaps in their coverage. The mappings indicated that there are no gaps in the security ideals and that the ten core technical metrics provide significant coverage of standard security issues with 87% coverage. Based

  3. Effects of the Ebbinghaus illusion on different behaviors: one- and two-handed grasping; one- and two-handed manual estimation; metric and comparative judgment.

    PubMed

    Vishton, Peter M; Fabre, Edward

    2003-01-01

    Many studies have suggested that visually-guided action is largely immune to the effects of several pictorial illusions that strongly influence perceptual judgments. The judgments in these experiments, however, have usually involved comparisons of multiple elements within a display, whereas the visually-guided actions have typically involved a pincer grip directed to only one display element. The three experiments presented here assess the influence of this confound on the perception versus action illusion dissociation. In general, the studies suggest (a) that the confound affects perceptual judgment but not grasping or manual estimation, and (b) that difficult visuomotor tasks are more affected by the Ebbinghaus illusion than easier tasks. In Experiment 1, participants reached for or made judgments about plastic disks placed in the center of the Ebbinghaus illusion display. Some participants reached for or made judgments about only the disk on the right, whereas others reached for or judged both disks simultaneously. A large effect of the illusion was found for grasping and comparative judgment, but not for manual estimation or metric judgment. In Experiment 2, the disks were elevated slightly to make gripping the targets easier, and the effects of the illusion on grasping were greatly reduced. For Experiment 3, participants performed the manual estimation task while the hands were placed in view, on the surface of the table, and the effects of the illusion were significantly increased. Taken together, the experiments indicate that task difficulty and hand visibility affect whether a task will be influenced by pictorial illusions or not. One- and two-handed grasping seem to be affected approximately equally.

  4. Environmental Decision Support with Consistent Metrics

    EPA Science Inventory

    One of the most effective ways to pursue environmental progress is through the use of consistent metrics within a decision making framework. The US Environmental Protection Agency’s Sustainable Technology Division has developed TRACI, the Tool for the Reduction and Assessment of...

  5. Resistance to genetic insect control: Modelling the effects of space.

    PubMed

    Watkinson-Powell, Benjamin; Alphey, Nina

    2017-01-21

    Genetic insect control, such as self-limiting RIDL(2) (Release of Insects Carrying a Dominant Lethal) technology, is a development of the sterile insect technique which is proposed to suppress wild populations of a number of major agricultural and public health insect pests. This is achieved by mass rearing and releasing male insects that are homozygous for a repressible dominant lethal genetic construct, which causes death in progeny when inherited. The released genetically engineered ('GE') insects compete for mates with wild individuals, resulting in population suppression. A previous study modelled the evolution of a hypothetical resistance to the lethal construct using a frequency-dependent population genetic and population dynamic approach. This found that proliferation of resistance is possible but can be diluted by the introgression of susceptible alleles from the released homozygous-susceptible GE males. We develop this approach within a spatial context by modelling the spread of a lethal construct and resistance trait, and the effect on population control, in a two deme metapopulation, with GE release in one deme. Results show that spatial effects can drive an increased or decreased evolution of resistance in both the target and non-target demes, depending on the effectiveness and associated costs of the resistant trait, and on the rate of dispersal. A recurrent theme is the potential for the non-target deme to act as a source of resistant or susceptible alleles for the target deme through dispersal. This can in turn have a major impact on the effectiveness of insect population control.

  6. Resistive Memory for Harsh Electronics: Immunity to Surface Effect and High Corrosion Resistance via Surface Modification

    PubMed Central

    Huang, Teng-Han; Yang, Po-Kang; Lien, Der-Hsien; Kang, Chen-Fang; Tsai, Meng-Lin; Chueh, Yu-Lun; He, Jr-Hau

    2014-01-01

    The tolerance/resistance of the electronic devices to extremely harsh environments is of supreme interest. Surface effects and chemical corrosion adversely affect stability and operation uniformity of metal oxide resistive memories. To achieve the surrounding-independent behavior, the surface modification is introduced into the ZnO memristors via incorporating fluorine to replace the oxygen sites. F-Zn bonds is formed to prevent oxygen chemisorption and ZnO dissolution upon corrosive atmospheric exposure, which effectively improves switching characteristics against harmful surroundings. In addition, the fluorine doping stabilizes the cycling endurance and narrows the distribution of switching parameters. The outcomes provide valuable insights for future nonvolatile memory developments in harsh electronics. PMID:24638086

  7. Simulating the Effect of Spectroscopic MRI as a Metric for Radiation Therapy Planning in Patients with Glioblastoma

    PubMed Central

    Cordova, J. Scott; Kandula, Shravan; Gurbani, Saumya; Zhong, Jim; Tejani, Mital; Kayode, Oluwatosin; Patel, Kirtesh; Prabhu, Roshan; Schreibmann, Eduard; Crocker, Ian; Holder, Chad A.; Shim, Hyunsuk; Shu, Hui-Kuo

    2017-01-01

    Due to glioblastoma’s infiltrative nature, an optimal radiation therapy (RT) plan requires targeting infiltration not identified by anatomical magnetic resonance imaging (MRI). Here, high-resolution, whole-brain spectroscopic MRI (sMRI) is used to describe tumor infiltration alongside anatomical MRI and simulate the degree to which it modifies RT target planning. In 11 patients with glioblastoma, data from preRT sMRI scans were processed to give high-resolution, whole-brain metabolite maps normalized by contralateral white matter. Maps depicting choline to N-Acetylaspartate (Cho/NAA) ratios were registered to contrast-enhanced T1-weighted RT planning MRI for each patient. Volumes depicting metabolic abnormalities (1.5−, 1.75−, and 2.0-fold increases in Cho/NAA ratios) were compared with conventional target volumes and contrast-enhancing tumor at recurrence. sMRI-modified RT plans were generated to evaluate target volume coverage and organ-at-risk dose constraints. Conventional clinical target volumes and Cho/NAA abnormalities identified significantly different regions of microscopic infiltration with substantial Cho/NAA abnormalities falling outside of the conventional 60 Gy isodose line (41.1, 22.2, and 12.7 cm3, respectively). Clinical target volumes using Cho/NAA thresholds exhibited significantly higher coverage of contrast enhancement at recurrence on average (92.4%, 90.5%, and 88.6%, respectively) than conventional plans (82.5%). sMRI-based plans targeting tumor infiltration met planning objectives in all cases with no significant change in target coverage. In 2 cases, the sMRI-modified plan exhibited better coverage of contrast-enhancing tumor at recurrence than the original plan. Integration of the high-resolution, whole-brain sMRI into RT planning is feasible, resulting in RT target volumes that can effectively target tumor infiltration while adhering to conventional constraints. PMID:28105468

  8. Metric Supplement to Technical Drawing.

    ERIC Educational Resources Information Center

    Henschel, Mark

    This manual is intended for use in training persons whose vocations involve technical drawing to use the metric system of measurement. It could be used in a short course designed for that purpose or for individual study. The manual begins with a brief discussion of the rationale for conversion to the metric system. It then provides a…

  9. How to Teach Metric Now.

    ERIC Educational Resources Information Center

    Worcester Public Schools, MA.

    This curriculum guide for grades K-6 was prepared to assist teachers and students in learning about the metric system. An introductory section presents a brief history of the metric system and the rationale for introducing it into the schools. Instructional objectives and suggested learning activities are presented for each grade level. The…

  10. Metric Activities, Grades K-6.

    ERIC Educational Resources Information Center

    Draper, Bob, Comp.

    This pamphlet presents worksheets for use in fifteen activities or groups of activities designed for teaching the metric system to children in grades K through 6. The approach taken in several of the activities is one of conversion between metric and English units. The majority of the activities concern length, area, volume, and capacity. A…

  11. Metrication: A Guide for Consumers.

    ERIC Educational Resources Information Center

    Consumer and Corporate Affairs Dept., Ottawa (Ontario).

    The widespread use of the metric system by most of the major industrial powers of the world has prompted the Canadian government to investigate and consider use of the system. This booklet was developed to aid the consuming public in Canada in gaining some knowledge of metrication and how its application would affect their present economy.…

  12. Metrics for Soft Goods Merchandising.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of students interested in soft goods merchandising, this instructional package is one of five for the marketing and distribution cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational…

  13. Metrics for Hard Goods Merchandising.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of students interested in hard goods merchandising, this instructional package is one of five for the marketing and distribution cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational…

  14. What About Metric? Revised Edition.

    ERIC Educational Resources Information Center

    Barbrow, Louis E.

    Described are the advantages of using the metric system over the English system. The most common units of both systems are listed and compared. Pictures are used to exhibit use of the metric system in connection with giving prices or sizes of common items. Several examples provide computations of area, total weight of several objects, and volume;…

  15. Multimetric indices: How many metrics?

    EPA Science Inventory

    Multimetric indices (MMI’s) often include 5 to 15 metrics, each representing a different attribute of assemblage condition, such as species diversity, tolerant taxa, and nonnative taxa. Is there an optimal number of metrics for MMIs? To explore this question, I created 1000 9-met...

  16. Metrical Phonology: German Sound System.

    ERIC Educational Resources Information Center

    Tice, Bradley S.

    Metrical phonology, a linguistic process of phonological stress assessment and diagrammatic simplification of sentence and word stress, is discussed as it is found in the English and German languages. The objective is to promote use of metrical phonology as a tool for enhancing instruction in stress patterns in words and sentences, particularly in…

  17. Effectiveness of Electroconvulsive Therapy Augmentation on Clozapine-Resistant Schizophrenia

    PubMed Central

    Kim, Hye Sung; Kim, Se Hyun; Lee, Nam Young; Youn, Tak; Lee, Jeoung Hyuk; Chung, Seunghyun; Kim, Yong Sik

    2017-01-01

    Objective This retrospective case series study of the effectiveness of electroconvulsive therapy (ECT) augmentation on clozapine-resistant schizophrenia was conducted by EMR review. Methods Clozapine-resistance was defined as persistent psychotic symptoms despite at least 12 weeks of clozapine administration with blood levels over 350 ng/mL in order to rule out pseudo-resistance. Seven in-patients who were taking clozapine and treated with ECT were selected. We analyzed the psychopathology and subscales changed by ECT. Results The average number of ECT sessions was 13.4 (±4.6). Total Positive and Negative Syndrome Scale (PANSS) score was significantly reduced by 17.9 (±12.8) points (p=0.0384) on average, which represented a reduction of 25.5% (±14.3). 71.4% (5/7) of patients were identified as clinical remission, with at least a 20% reduction in PANSS score. PANSS reduction was associated with number of ECT sessions, stimulus level in the final session, and blood clozapine levels before ECT. However, the negative subscale on the PANSS were not reduced by ECT in any patient. We did not observe any persistent adverse cognitive effects. Conclusion This study supports that ECT augmentation on clozapine-resistant schizophrenia reveals clinically effective and safe. Further research should be done involving a larger number of patients to investigate the effectiveness of clozapine/ECT combination therapy. PMID:28096876

  18. Metrication report to the Congress

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The major NASA metrication activity of 1988 concerned the Space Station. Although the metric system was the baseline measurement system for preliminary design studies, solicitations for final design and development of the Space Station Freedom requested use of the inch-pound system because of concerns with cost impact and potential safety hazards. Under that policy, however use of the metric system would be permitted through waivers where its use was appropriate. Late in 1987, several Department of Defense decisions were made to increase commitment to the metric system, thereby broadening the potential base of metric involvement in the U.S. industry. A re-evaluation of Space Station Freedom units of measure policy was, therefore, initiated in January 1988.

  19. Enhanced oxidation resistance of active nanostructures via dynamic size effect

    NASA Astrophysics Data System (ADS)

    Liu, Yun; Yang, Fan; Zhang, Yi; Xiao, Jianping; Yu, Liang; Liu, Qingfei; Ning, Yanxiao; Zhou, Zhiwen; Chen, Hao; Huang, Wugen; Liu, Ping; Bao, Xinhe

    2017-02-01

    A major challenge limiting the practical applications of nanomaterials is that the activities of nanostructures (NSs) increase with reduced size, often sacrificing their stability in the chemical environment. Under oxidative conditions, NSs with smaller sizes and higher defect densities are commonly expected to oxidize more easily, since high-concentration defects can facilitate oxidation by enhancing the reactivity with O2 and providing a fast channel for oxygen incorporation. Here, using FeO NSs as an example, we show to the contrary, that reducing the size of active NSs can drastically increase their oxidation resistance. A maximum oxidation resistance is found for FeO NSs with dimensions below 3.2 nm. Rather than being determined by the structure or electronic properties of active sites, the enhanced oxidation resistance originates from the size-dependent structural dynamics of FeO NSs in O2. We find this dynamic size effect to govern the chemical properties of active NSs.

  20. Effect of Photoperiod On Permethrin Resistance In Aedes aegypti.

    PubMed

    Villanueva, O Karina; Ponce, Gustavo; Lopez, Beatriz; Gutierrez, Selene M; Rodriguez, Iram P; Reyes, Guadalupe; Saavedra, Karla J; Black, William C; Garcia, Julian; Beaty, Barry; Eisen, Lars; Flores, Adriana E

    2016-12-01

    Living organisms have been exposed to light-dark cycles that allowed them to adapt to different ecological niches. Circadian cycles affect hormone release, metabolism, and response to xenobiotic compounds. Current studies have shown that insect susceptibility to toxic agents depends on circadian cycles, mainly because the biochemical processes involved in detoxification and responses to oxidative stress are modulated by this process. The goal of this study was to determine the effect of photoperiod on resistance to permethrin in Aedes aegypti . Collections of Ae. aegypti from 4 locations in Yucatan, southern Mexico, were subjected to 2 different photoperiod schemes: dark (0 h light:24 h dark) and natural photoperiod (12 h light:12 h dark). The comparison of both photoperiods was evaluated with respect to permethrin resistance using bottle bioassays and by monitoring the possible mechanism related such as enzymatic activity and by the frequency of 2 knockdown resistance mutations in the voltage-dependent sodium channel gene (V1016I and F1534C). The susceptible strain was used as a reference. The mosquitoes in dark photoperiod showed a reduction in resistance to the pyrethroid. The α-esterases and glutathione S-transferase enzymatic activities showed lower levels in the dark photoperiod, and the frequencies of V1016I knockdown resistance mutation showed significant difference between photoperiod schemes.

  1. Effects of sol aging on resistive switching behaviors of HfOx resistive memories

    NASA Astrophysics Data System (ADS)

    Hsu, Chih-Chieh; Sun, Jhen-Kai; Tsao, Che-Chang; Chen, Yu-Ting

    2017-03-01

    This work investigates effects of long-term sol-aging time on sol-gel HfOx resistive random access memories (RRAMs). A nontoxic solvent of ethanol is used to replace toxic 2-methoxyethanol, which is usually used in sol-gel processes. The top electrodes are fabricated by pressing indium balls onto the HfOx surface rather than by using conventional sputtering or evaporation processes. The maximum process temperature is limited to be 100 ℃. Therefore, influences of plasma and high temperature on HfOx film can be avoided. Under this circumstance, effects of sol aging time on the HfOx films can be more clearly studied. The current conduction mechanisms in low and high electric regions of the HfOx RRAM are found to be dominated by Ohmic conduction and trap-filled space charge limited conduction (TF-SCLC), respectively. When the sol aging time increases, the resistive switching characteristic of the HfOx layer becomes unstable and the transition voltage from Ohmic conduction to TF-SCLC is also increased. This suggests that an exceedingly long aging time will give a HfOx film with more defect states. The XPS results are consistent with FTIR analysis and they can further explain the unstable HfOx resistive switching characteristic induced by sol aging.

  2. The effective resistance between twisted superconducting filaments in tapes

    NASA Astrophysics Data System (ADS)

    Takács, S.; Iwakuma, M.; Funaki, K.

    2001-05-01

    We consider two mechanisms, which influence the effective resistance between crossing strands on flat cables or filaments in twisted tapes. The one-layer classical Rutherford-type cable and the tapes with twisted BSCCO filaments in silver matrix are taken as analogous cases. The amount of the matrix between strands or filaments increases the effective conductance compared with the direct current paths (determined by the touching area of the filaments). The increase factor is about two and can easily be suppressed by other effects, like the contact resistance between the superconductor and the matrix. The second mechanism is due to the existence of induced voltage between any points of crossing filaments. This leads to an additional effective conductance, proportional to the square of the total number of filaments. Both effects are not very important for isotropic superconductors, but due to the strong anisotropy of critical parameters they can dominate for high temperature superconductors. The first one may partially compensate the influence of the usually weaker critical current density perpendicular to the tape. The contribution due to the second effect can explain the higher resistivity of the matrix in BSCCO tapes compared with pure silver. It seems that to obtain low AC coupling losses in BSCCO tapes, structures with small filament number are required.

  3. Edge effect on resistance scaling rules in graphene nanostructures.

    PubMed

    Xu, Guangyu; Torres, Carlos M; Tang, Jianshi; Bai, Jingwei; Song, Emil B; Huang, Yu; Duan, Xiangfeng; Zhang, Yuegang; Wang, Kang L

    2011-03-09

    We report an experimental investigation of the edge effect on the room-temperature transport in graphene nanoribbon and graphene sheet (both single-layer and bilayer). By measuring the resistance scaling behaviors at both low- and high-carrier densities, we show that the transport of single-layer nanoribbons lies in a strong localization regime, which can be attributed to an edge effect. We find that this edge effect can be weakened by enlarging the width, decreasing the carrier densities, or adding an extra layer. From graphene nanoribbon to graphene sheet, the data show a dimensional crossover of the transport regimes possibly due to the drastic change of the edge effect.

  4. Variable metric conjugate gradient methods

    SciTech Connect

    Barth, T.; Manteuffel, T.

    1994-07-01

    1.1 Motivation. In this paper we present a framework that includes many well known iterative methods for the solution of nonsymmetric linear systems of equations, Ax = b. Section 2 begins with a brief review of the conjugate gradient method. Next, we describe a broader class of methods, known as projection methods, to which the conjugate gradient (CG) method and most conjugate gradient-like methods belong. The concept of a method having either a fixed or a variable metric is introduced. Methods that have a metric are referred to as either fixed or variable metric methods. Some relationships between projection methods and fixed (variable) metric methods are discussed. The main emphasis of the remainder of this paper is on variable metric methods. In Section 3 we show how the biconjugate gradient (BCG), and the quasi-minimal residual (QMR) methods fit into this framework as variable metric methods. By modifying the underlying Lanczos biorthogonalization process used in the implementation of BCG and QMR, we obtain other variable metric methods. These, we refer to as generalizations of BCG and QMR.

  5. Effect of ambient on the resistance fluctuations of graphene

    NASA Astrophysics Data System (ADS)

    Amin, Kazi Rafsanjani; Bid, Aveek

    2015-05-01

    In this letter, we present the results of systematic experimental investigations of the effect of different chemical environments on the low frequency resistance fluctuations of single layer graphene field effect transistors. The shape of the power spectral density of noise was found to be determined by the energetics of the adsorption-desorption of molecules from the graphene surface making it the dominant source of noise in these devices. We also demonstrate a method of quantitatively determining the adsorption energies of chemicals on graphene surface based on noise measurements. We find that the magnitude of noise is extremely sensitive to the nature and amount of the chemical species present. We propose that a chemical sensor based on the measurement of low frequency resistance fluctuations of single layer graphene field effect transistor devices will have extremely high sensitivity, very high specificity, high fidelity, and fast response times.

  6. GPS Metric Tracking Unit

    NASA Technical Reports Server (NTRS)

    2008-01-01

    As Global Positioning Satellite (GPS) applications become more prevalent for land- and air-based vehicles, GPS applications for space vehicles will also increase. The Applied Technology Directorate of Kennedy Space Center (KSC) has developed a lightweight, low-cost GPS Metric Tracking Unit (GMTU), the first of two steps in developing a lightweight, low-cost Space-Based Tracking and Command Subsystem (STACS) designed to meet Range Safety's link margin and latency requirements for vehicle command and telemetry data. The goals of STACS are to improve Range Safety operations and expand tracking capabilities for space vehicles. STACS will track the vehicle, receive commands, and send telemetry data through the space-based asset, which will dramatically reduce dependence on ground-based assets. The other step was the Low-Cost Tracking and Data Relay Satellite System (TDRSS) Transceiver (LCT2), developed by the Wallops Flight Facility (WFF), which allows the vehicle to communicate with a geosynchronous relay satellite. Although the GMTU and LCT2 were independently implemented and tested, the design collaboration of KSC and WFF engineers allowed GMTU and LCT2 to be integrated into one enclosure, leading to the final STACS. In operation, GMTU needs only a radio frequency (RF) input from a GPS antenna and outputs position and velocity data to the vehicle through a serial or pulse code modulation (PCM) interface. GMTU includes one commercial GPS receiver board and a custom board, the Command and Telemetry Processor (CTP) developed by KSC. The CTP design is based on a field-programmable gate array (FPGA) with embedded processors to support GPS functions.

  7. Double metric, generalized metric, and α' -deformed double field theory

    NASA Astrophysics Data System (ADS)

    Hohm, Olaf; Zwiebach, Barton

    2016-03-01

    We relate the unconstrained "double metric" of the "α' -geometry" formulation of double field theory to the constrained generalized metric encoding the spacetime metric and b -field. This is achieved by integrating out auxiliary field components of the double metric in an iterative procedure that induces an infinite number of higher-derivative corrections. As an application, we prove that, to first order in α' and to all orders in fields, the deformed gauge transformations are Green-Schwarz-deformed diffeomorphisms. We also prove that to first order in α' the spacetime action encodes precisely the Green-Schwarz deformation with Chern-Simons forms based on the torsionless gravitational connection. This seems to be in tension with suggestions in the literature that T-duality requires a torsionful connection, but we explain that these assertions are ambiguous since actions that use different connections are related by field redefinitions.

  8. In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures.

    PubMed

    Broeders, Jessica J W; Blaauboer, Bas J; Hermens, Joop L M

    2013-04-01

    The extrapolation of in vitro to in vivo toxicity data is a challenge. Differences in sensitivity between cell systems may be due to intrinsic properties of the cell but also because of differences in exposure. In this study, the cytotoxicity and biokinetics of the antipsychotic chlorpromazine (CPZ) were studied in in vitro assays using different cell types and exposure conditions. Different dose metrics were assessed to express the sensitivity to CPZ. The biokinetics of CPZ were measured in cell cultures of Balb/c 3T3, Caco-2 and HepaRG cells. Cytotoxicity was measured by Alamar Blue and expressed using different dose metrics, including the nominal, measured total and measured free CPZ medium concentrations. CPZ was taken up by the cells; the highest amounts in the cell compartments were found in the Caco-2 and HepaRG cells. CPZ was highly protein-bound in the Caco-2 cell medium containing 10% fetal bovine serum, resulting in lower bioavailable exposure concentrations. Moreover, also uptake into the cells strongly influenced the concentration in the medium. The Balb/c 3T3 cells were the most sensitive to the toxic effect of CPZ. The use of different dose metrics influenced the cytotoxicity results found in the three cell types. The data show that in comparing the sensitivity of the tested cell systems, the freely dissolved concentration is a more appropriate dose metric than total concentration in the medium. The ranking in sensitivity of the three cell types for CPZ was dependent on the dose metric used.

  9. Daylight metrics and energy savings

    SciTech Connect

    Mardaljevic, John; Heschong, Lisa; Lee, Eleanor

    2009-12-31

    The drive towards sustainable, low-energy buildings has increased the need for simple, yet accurate methods to evaluate whether a daylit building meets minimum standards for energy and human comfort performance. Current metrics do not account for the temporal and spatial aspects of daylight, nor of occupants comfort or interventions. This paper reviews the historical basis of current compliance methods for achieving daylit buildings, proposes a technical basis for development of better metrics, and provides two case study examples to stimulate dialogue on how metrics can be applied in a practical, real-world context.

  10. Truss Performance and Packaging Metrics

    NASA Technical Reports Server (NTRS)

    Mikulas, Martin M.; Collins, Timothy J.; Doggett, William; Dorsey, John; Watson, Judith

    2006-01-01

    In the present paper a set of performance metrics are derived from first principals to assess the efficiency of competing space truss structural concepts in terms of mass, stiffness, and strength, for designs that are constrained by packaging. The use of these performance metrics provides unique insight into the primary drivers for lowering structural mass and packaging volume as well as enabling quantitative concept performance evaluation and comparison. To demonstrate the use of these performance metrics, data for existing structural concepts are plotted and discussed. Structural performance data is presented for various mechanical deployable concepts, for erectable structures, and for rigidizable structures.

  11. A multi-metric assessment of environmental contaminant exposure and effects in an urbanized reach of the Charles River near Watertown, Massachusetts

    USGS Publications Warehouse

    Smith, Stephen B.; Anderson, Patrick J.; Baumann, Paul C.; DeWeese, Lawrence R.; Goodbred, Steven L.; Coyle, James J.; Smith, David S.

    2012-01-01

    The Charles River Project provided an opportunity to simultaneously deploy a combination of biomonitoring techniques routinely used by the U.S. Geological Survey National Water Quality Assessment Program, the Biomonitoring of Environmental Status and Trends Project, and the Contaminant Biology Program at an urban site suspected to be contaminated with polycyclic aromatic hydrocarbons. In addition to these standardized methods, additional techniques were used to further elucidate contaminant exposure and potential impacts of exposure on biota. The purpose of the study was to generate a comprehensive, multi-metric data set to support assessment of contaminant exposure and effects at the site. Furthermore, the data set could be assessed to determine the relative performance of the standardized method suites typically used by the National Water Quality Assessment Program and the Biomonitoring of Environmental Status and Trends Project, as well as the additional biomonitoring methods used in the study to demonstrate ecological effects of contaminant exposure. The Contaminant Effects Workgroup, an advisory committee of the U.S. Geological Survey/Contaminant Biology Program, identified polycyclic aromatic hydrocarbons as the contaminant class of greatest concern in urban streams of all sizes. The reach of the Charles River near Watertown, Massachusetts, was selected as the site for this study based on the suspected presence of polycyclic aromatic hydrocarbon contamination and the presence of common carp (Cyprinus carpio), largemouth bass (Micropterus salmoides), and white sucker (Catostomus commersoni). All of these fish have extensive contaminant-exposure profiles related to polycyclic aromatic hydrocarbons and other environmental contaminants. This project represented a collaboration of universities, Department of the Interior bureaus including multiple components of the USGS (Biological Resources Discipline and Water Resources Discipline Science Centers, the

  12. The LSST metrics analysis framework (MAF)

    NASA Astrophysics Data System (ADS)

    Jones, R. L.; Yoachim, Peter; Chandrasekharan, Srinivasan; Connolly, Andrew J.; Cook, Kem H.; Ivezic, Željko; Krughoff, K. S.; Petry, Catherine; Ridgway, Stephen T.

    2014-07-01

    We describe the Metrics Analysis Framework (MAF), an open-source python framework developed to provide a user-friendly, customizable, easily-extensible set of tools for analyzing data sets. MAF is part of the Large Synoptic Survey Telescope (LSST) Simulations effort. Its initial goal is to provide a tool to evaluate LSST Operations Simulation (OpSim) simulated surveys to help understand the effects of telescope scheduling on survey performance, however MAF can be applied to a much wider range of datasets. The building blocks of the framework are Metrics (algorithms to analyze a given quantity of data), Slicers (subdividing the overall data set into smaller data slices as relevant for each Metric), and Database classes (to access the dataset and read data into memory). We describe how these building blocks work together, and provide an example of using MAF to evaluate different dithering strategies. We also outline how users can write their own custom Metrics and use these within the framework.

  13. Standardised metrics for global surgical surveillance.

    PubMed

    Weiser, Thomas G; Makary, Martin A; Haynes, Alex B; Dziekan, Gerald; Berry, William R; Gawande, Atul A

    2009-09-26

    Public health surveillance relies on standardised metrics to evaluate disease burden and health system performance. Such metrics have not been developed for surgical services despite increasing volume, substantial cost, and high rates of death and disability associated with surgery. The Safe Surgery Saves Lives initiative of WHO's Patient Safety Programme has developed standardised public health metrics for surgical care that are applicable worldwide. We assembled an international panel of experts to develop and define metrics for measuring the magnitude and effect of surgical care in a population, while taking into account economic feasibility and practicability. This panel recommended six measures for assessing surgical services at a national level: number of operating rooms, number of operations, number of accredited surgeons, number of accredited anaesthesia professionals, day-of-surgery death ratio, and postoperative in-hospital death ratio. We assessed the feasibility of gathering such statistics at eight diverse hospitals in eight countries and incorporated them into the WHO Guidelines for Safe Surgery, in which methods for data collection, analysis, and reporting are outlined.

  14. Vehicle Integrated Prognostic Reasoner (VIPR) Metric Report

    NASA Technical Reports Server (NTRS)

    Cornhill, Dennis; Bharadwaj, Raj; Mylaraswamy, Dinkar

    2013-01-01

    This document outlines a set of metrics for evaluating the diagnostic and prognostic schemes developed for the Vehicle Integrated Prognostic Reasoner (VIPR), a system-level reasoner that encompasses the multiple levels of large, complex systems such as those for aircraft and spacecraft. VIPR health managers are organized hierarchically and operate together to derive diagnostic and prognostic inferences from symptoms and conditions reported by a set of diagnostic and prognostic monitors. For layered reasoners such as VIPR, the overall performance cannot be evaluated by metrics solely directed toward timely detection and accuracy of estimation of the faults in individual components. Among other factors, overall vehicle reasoner performance is governed by the effectiveness of the communication schemes between monitors and reasoners in the architecture, and the ability to propagate and fuse relevant information to make accurate, consistent, and timely predictions at different levels of the reasoner hierarchy. We outline an extended set of diagnostic and prognostics metrics that can be broadly categorized as evaluation measures for diagnostic coverage, prognostic coverage, accuracy of inferences, latency in making inferences, computational cost, and sensitivity to different fault and degradation conditions. We report metrics from Monte Carlo experiments using two variations of an aircraft reference model that supported both flat and hierarchical reasoning.

  15. Reuse metrics and measurement: A framework

    NASA Technical Reports Server (NTRS)

    Reifer, Donald J.

    1990-01-01

    The lessons learned and experience gleaned are described by those who have started to implement the reuse metrics and measurement framework used in controlling the development of common avionics and software for its affiliated aircraft programs. The framework was developed to permit the measurement of the long term cost/benefits resulting from the creation and use of Reusable Software Objects (RSOs). The framework also monitors the efficiency and effectiveness of the Software Reuse Library (SRL). The metrics and measurement framework is defined which was established to allow some determinations and findings to be made relative to software reuse. Seven criteria are discussed which were used to guide the establishment of the proposed reuse framework. Object recapture and creation metrics are explained along with their normalized use in effort, productivity, and quality determination. A single and multiple reuse instance version of a popular cost model is presented which uses these metrics and the measurement scheme proposed to predict the software effort and duration under various reuse assumptions. Studies in using this model to predict actuals taken from the RCI data base of over 1000 completed projects is discussed.

  16. Relating reconnection rate, exhaust structure and effective resistivity

    SciTech Connect

    Singh, Nagendra

    2014-03-15

    The magnetic reconnection structure consists of a central diffusion region (CDR) and a cone or wedge shaped reconnection exhaust containing accelerated plasma flows and electromagnetic fluctuations. We predict here the relationship among the exhaust half-cone angle (θ{sub e}), the half width (w) of the CDR, the outflow velocity V{sub o}, and the effective resistivity (η{sub eff}), which includes the effects of all the nonideal terms in the generalized Ohm's law. The effective resistivity is defined as the ratio of reconnection electric field E{sub rec} to the current density J{sub y} at the X point and it essentially represents the loss of momentum from the current-carrying plasma particles due to scattering by waves, their inertia or outflux from the CDR. The relation is checked against relevant results previously reported from laboratory experiments, space observations, and simulations, showing excellent agreement. The relation can be used for estimating the ad-hoc effective resistivity often used in magnetohydrodynamic modeling of reconnection.

  17. Fast plasma heating by anomalous and inertial resistivity effects

    NASA Technical Reports Server (NTRS)

    Duijveman, A.; Hoyng, P.; Ionson, J. A.

    1981-01-01

    Fast plasma heating by anomalous and inertial resistivity effects is described. A small fraction of the plasma contains strong currents that run parallel to the magnetic field and are driven by an exponentiating electric field. The anomalous character of the current dissipation is caused by the excitation of electrostatic ion cyclotron and/or ion acoustic waves. The role of resistivity due to geometrical effects is considered. Through the use of a marginal stability analysis, equations for the average electron and ion temperatures are derived and numerically solved. The evolution of the plasma is described as a path in the drift velocity diagram, in which the drift velocity is plotted as a function of the electron to ion temperature ratio.

  18. Using TRACI for Sustainability Metrics

    EPA Science Inventory

    TRACI, the Tool for the Reduction and Assessment of Chemical and other environmental Impacts, has been developed for sustainability metrics, life cycle impact assessment, and product and process design impact assessment for developing increasingly sustainable products, processes,...

  19. Let's Make Metric Ice Cream

    ERIC Educational Resources Information Center

    Zimmerman, Marianna

    1975-01-01

    Describes a classroom activity which involved sixth grade students in a learning situation including making ice cream, safety procedures in a science laboratory, calibrating a thermometer, using metric units of volume and mass. (EB)

  20. The effect of preexercise carbohydrate status on resistance exercise performance.

    PubMed

    Mitchell, J B; DiLauro, P C; Pizza, F X; Cavender, D L

    1997-09-01

    The purpose of this study was to determine the effect of a high vs. a low preexercise carbohydrate (CHO) diet on performance during multiple sets of resistance exercise. Eleven resistance-trained males performed cycle ergometry to deplete quadriceps muscle glycogen stores, followed by 48 hr of a high (HICHO) or a low (LOCHO) CHO diet. Subjects then performed five sets each of squats, leg presses, and knee extensions (resistance = 15 RM) to failure. Blood samples were taken before and during exercise for determination of glucose and lactate (LA). No differences in performance (repetitions x weight lifted) were observed (HICHO = 15,975 +/- 1,381 and LOCHO = 15,723 +/- 1,231 kg). Blood glucose was significantly higher after exercise for HICHO compared to LOCHO (HICHO = 4.8 +/- 0.2 vs. LOCHO = 3.9 +/- 0.2 mmol.L-1). No differences in LA accumulation were observed. The data indicated that preexercise CHO status did not affect resistance exercise performance. Further, the differences in blood glucose and the similarity in LA responses suggest that glycolysis was maintained in the LOCHO condition, and there may have been an increased reliance on blood glucose when preexercise CHO status was low.

  1. [Effect of transgenic insect-resistant rice on biodiversity].

    PubMed

    Zhang, Lei; Zhu, Zhen

    2011-05-01

    Rice is the most important food crops in maintaining food security in China. The loss of China's annual rice production caused by pests is over ten million tons. Present studies showed that the transgenic insect-resistant rice can substantially reduce the application amount of chemical pesticides. In the case of no pesticide use, the pest density in transgenic rice field is significantly lower than that in non-transgenic field, and the neutral insects and natural enemies of pests increased significantly, indicating that the ecological environment and biodiversity toward the positive direction. The gene flow frequency from transgenic rice is dramatically reduced with the distance increases, reaching less than 0.01% at the distance of 6.2 m. Application of transgenic insect-resistant rice in China has an important significance for ensuring food security, maintaining sustainable agricultural development, and protecting the ecological environment and biodiversity. This review summarized the research progress in transgenic insect-resistant rice and its effect on biodiversity. The research directions and development trends of crop pest controlling in future are discussed. These help to promote better use of transgenic insect-resistant rice.

  2. Resistance blow-up effect in micro-circuit engineering

    NASA Astrophysics Data System (ADS)

    Tan, Michael L. P.; Saxena, Tanuj; Arora, Vijay K.

    2010-12-01

    The nonlinearity in the I- V characteristics of a scaled-down micro/nano-scale resistive channel is shown to elevate the DC and signal resistance as current approaches its saturation value. The deviation from traditional circuit engineering takes place when the applied voltage is increased beyond the critical voltage V c = ( V t/ ℓ) L, where V t is the thermal voltage, ℓ is the ohmic mean free path, and L is the length of the conducting channel. This resistance blow-up is more pronounced for a smaller-length resistor in a micro-circuit of two resistors with same ohmic value. The power consumed P = VI not only is lower but also is a linear function of voltage V as compared to the quadratic rise with V in the ohmic regime. The resistance blow-up effect also gives enhanced RC time constant for transients when a digital signal switches from low to high or vice versa. These results are of immense value to circuit designers and those doing device characterization to extract parasitic and transport parameters.

  3. A universal metric for ferroic energy materials.

    PubMed

    Brück, Ekkes; Yibole, Hargen; Zhang, Lian

    2016-08-13

    After almost 20 years of intensive research on magnetocaloric effects near room temperature, magnetic refrigeration with first-order magnetocaloric materials has come close to real-life applications. Many materials have been discussed as potential candidates to be used in multicaloric devices. However, phase transitions in ferroic materials are often hysteretic and a metric is needed to estimate the detrimental effects of this hysteresis. We propose the coefficient of refrigerant performance, which compares the net work in a reversible cycle with the positive work on the refrigerant, as a universal metric for ferroic materials. Here, we concentrate on examples from magnetocaloric materials and only consider one barocaloric experiment. This is mainly due to lack of data on electrocaloric materials. It appears that adjusting the field-induced transitions and the hysteresis effects can minimize the losses in first-order materials.This article is part of the themed issue 'Taking the temperature of phase transitions in cool materials'.

  4. A universal metric for ferroic energy materials

    PubMed Central

    Yibole, Hargen; Zhang, Lian

    2016-01-01

    After almost 20 years of intensive research on magnetocaloric effects near room temperature, magnetic refrigeration with first-order magnetocaloric materials has come close to real-life applications. Many materials have been discussed as potential candidates to be used in multicaloric devices. However, phase transitions in ferroic materials are often hysteretic and a metric is needed to estimate the detrimental effects of this hysteresis. We propose the coefficient of refrigerant performance, which compares the net work in a reversible cycle with the positive work on the refrigerant, as a universal metric for ferroic materials. Here, we concentrate on examples from magnetocaloric materials and only consider one barocaloric experiment. This is mainly due to lack of data on electrocaloric materials. It appears that adjusting the field-induced transitions and the hysteresis effects can minimize the losses in first-order materials. This article is part of the themed issue ‘Taking the temperature of phase transitions in cool materials’. PMID:27402924

  5. Metric Selection for Ecosystem Restoration

    DTIC Science & Technology

    2013-06-01

    Conceptual modeling can be used in a situation where there is little funding for monitoring and evaluation planning, and when planning needs to be done...ecosystem restoration monitoring and evaluation programs, compile a list of these previous metrics, and assess and narrow them down based on...and understanding of the system will likely correlate with the benefits gained from monitoring and evaluation . A more appropriate, robust metric

  6. Validity of ligand efficiency metrics.

    PubMed

    Murray, Christopher W; Erlanson, Daniel A; Hopkins, Andrew L; Keserü, György M; Leeson, Paul D; Rees, David C; Reynolds, Charles H; Richmond, Nicola J

    2014-06-12

    A recent viewpoint article (Improving the plausibility of success with inefficient metrics. ACS Med. Chem. Lett. 2014, 5, 2-5) argued that the standard definition of ligand efficiency (LE) is mathematically invalid. In this viewpoint, we address this criticism and show categorically that the definition of LE is mathematically valid. LE and other metrics such as lipophilic ligand efficiency (LLE) can be useful during the multiparameter optimization challenge faced by medicinal chemists.

  7. Coverage Metrics for Model Checking

    NASA Technical Reports Server (NTRS)

    Penix, John; Visser, Willem; Norvig, Peter (Technical Monitor)

    2001-01-01

    When using model checking to verify programs in practice, it is not usually possible to achieve complete coverage of the system. In this position paper we describe ongoing research within the Automated Software Engineering group at NASA Ames on the use of test coverage metrics to measure partial coverage and provide heuristic guidance for program model checking. We are specifically interested in applying and developing coverage metrics for concurrent programs that might be used to support certification of next generation avionics software.

  8. Degraded visual environment image/video quality metrics

    NASA Astrophysics Data System (ADS)

    Baumgartner, Dustin D.; Brown, Jeremy B.; Jacobs, Eddie L.; Schachter, Bruce J.

    2014-06-01

    A number of image quality metrics (IQMs) and video quality metrics (VQMs) have been proposed in the literature for evaluating techniques and systems for mitigating degraded visual environments. Some require both pristine and corrupted imagery. Others require patterned target boards in the scene. None of these metrics relates well to the task of landing a helicopter in conditions such as a brownout dust cloud. We have developed and used a variety of IQMs and VQMs related to the pilot's ability to detect hazards in the scene and to maintain situational awareness. Some of these metrics can be made agnostic to sensor type. Not only are the metrics suitable for evaluating algorithm and sensor variation, they are also suitable for choosing the most cost effective solution to improve operating conditions in degraded visual environments.

  9. Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy

    PubMed Central

    Lee, Jinsoo; Son, Kwanghyun; Hwang, Gwiseo

    2016-01-01

    Objective. Herbal medicine has been widely used to treat drug resistant epilepsy. Shihogyejitang (SGT) has been commonly used to treat epilepsy. We investigated the effect and safety of SGT in children with drug resistant epilepsy. Design. We reviewed medical records of 54 patients with epilepsy, who failed to respond to at least two antiepileptic drugs and have been treated with SGT between April 2006 and June 2014 at the Department of Pediatric Neurology, I-Tomato Hospital, Korea. Effect was measured by the response rate, seizure-free rate, and retention rate at six months. We also checked adverse events, change in antiepileptic drugs use, and the variables related to the outcome. Results. Intent-to-treat analysis showed that, after six months, 44.4% showed a >50% seizure reduction, 24.1% including seizure-free, respectively, and 53.7% remained on SGT. Two adverse events were reported, mild skin rash and fever. Focal seizure type presented significantly more positive responses when compared with other seizure types at six months (p = 0.0284, Fisher's exact test). Conclusion. SGT is an effective treatment with excellent tolerability for drug resistant epilepsy patients. Our data provide evidence that SGT may be used as alternative treatment option when antiepileptic drug does not work in epilepsy children. PMID:27047568

  10. Finite element analysis of the effect of electrode resistivity on resistivity measurement in a diamond anvil cell

    NASA Astrophysics Data System (ADS)

    Huang, Xiaowei; Gao, Chunxiao; Zhang, Dongmei; Li, Ming; He, Chunyuan; Hao, Aimin; Yu, Cuiling; Sang, Chong; Liu, Cailong; Wang, Yue; Guan, Rui; Li, Dongmei; Zou, Guangtian; Ma, Yanzhang

    2007-05-01

    The effect of electrode resistivity on the in situ resistivity measurement in a diamond anvil cell was studied using finite element analysis. The theoretical analysis reveals that the origin of significant error for a thin sample is mainly caused by the resistivity difference between the electrodes and the sample. The authors found that reducing such resistivity differences can improve the accuracy. The result shows that the van der Pauw method [L. J. van der Pauw, Philips Tech. Rev. 20, 220 (1958)] can provide more accurate results for thin samples compared with the four-point probe method. This approach provides means to simulate actual experiments and to eliminate the measurement error.

  11. Scale-dependent effects of land cover on water physico-chemistry and diatom-based metrics in a major river system, the Adour-Garonne basin (South Western France).

    PubMed

    Tudesque, Loïc; Tisseuil, Clément; Lek, Sovan

    2014-01-01

    The scale dependence of ecological phenomena remains a central issue in ecology. Particularly in aquatic ecology, the consideration of the accurate spatial scale in assessing the effects of landscape factors on stream condition is critical. In this context, our study aimed at assessing the relationships between multi-spatial scale land cover patterns and a variety of water quality and diatom metrics measured at the stream reach level. This investigation was conducted in a major European river system, the Adour-Garonne river basin, characterized by a wide range of ecological conditions. Redundancy analysis (RDA) and variance partitioning techniques were used to disentangle the different relationships between land cover, water-chemistry and diatom metrics. Our results revealed a top-down "cascade effect" indirectly linking diatom metrics to land cover patterns through water physico-chemistry, which occurred at the largest spatial scales. In general, the strength of the relationships between land cover, physico-chemistry, and diatoms was shown to increase with the spatial scale, from the local to the basin scale, emphasizing the importance of continuous processes of accumulation throughout the river gradient. Unexpectedly, we established that the influence of land cover on the diatom metric was of primary importance both at the basin and local scale, as a result of discontinuous but not necessarily antagonist processes. The most detailed spatial grain of the Corine land cover classification appeared as the most relevant spatial grain to relate land cover to water chemistry and diatoms. Our findings provide suitable information to improve the implementation of effective diatom-based monitoring programs, especially within the scope of the European Water Framework Directive.

  12. Shaping Effects on Resistive-Plasma Resistive-Wall Mode Stability in a Tokamak

    NASA Astrophysics Data System (ADS)

    Rhodes, Dov; Cole, A. J.; Navratil, G. A.; Levesque, J. P.; Mauel, M. E.; Brennan, D. P.; Finn, J. M.; Fitzpatrick, R.

    2016-10-01

    A sharp-boundary MHD model is used to explore the effects of toroidal curvature and cross-sectional shaping on resistive-plasma resistive-wall modes in a tokamak. Building on the work of Fitzpatrick, we investigate mode stability with fixed toroidal number n =1 and a broad spectrum of poloidal m-numbers, given varying aspect-ratio, elongation, triangularity and up-down asymmetry. The speed and versatility of the sharp-boundary model facilitate exploration of a large parameter space, revealing qualitative trends to be further investigated by larger codes. In addition, the study addresses the effect of geometric mode-coupling on higher beta stability limits associated with an ideal-plasma or ideal-wall. These beta limits were used by Brennan and Finn to identify plasma response domains for feedback control. Present results show how geometric mode-coupling affects the stability limits and plasma response domains. The results are explained by an analytic reduced-MHD model with two coupled modes having different m-numbers. The next phase of this work will explore feedback control in different tokamak geometries. Supported by U.S. DOE Grant DE-FG02-86ER53222.

  13. Repeated bout effect is absent in resistance trained men

    PubMed Central

    Falvo, Michael J.; Schilling, Brian K.; Bloomer, Richard J.; Smith, Webb A.

    2009-01-01

    A prior bout of exercise is well known to confer protection from subsequent eccentric bouts (i.e. repeated bout effect; RBE), which may be fostered through neural adaptations, specifically a shift in the frequency content of the surface electromyogram (EMG). It is currently not clear whether chronically resistance trained men are capable of a RBE driven by neural adaptations. Eleven resistance trained men (23.5 ± 3.4 yrs) performed 100 eccentric actions of the barbell bench press exercise, followed by an equivalent bout 14 days later. Indirect markers of muscle damage (i.e. force production, soreness) along with surface EMG were measured before and through 48 h of recovery. Median frequency and maximal isometric force demonstrated time main effects (p > 0.05), but no RBE. A prior bout of eccentric exercise does not confer a RBE for indirect markers of muscle injury or elicit changes in the frequency content of the EMG signal in resistance trained men. PMID:19059793

  14. Edge effect in ohmic contacts on high-resistivity semiconductors

    NASA Astrophysics Data System (ADS)

    Ruzin, Arie

    2016-01-01

    Current increase due to edge effect in ohmic contacts was calculated by finite-element software in three-dimensional devices. The emphasis in this study is on semi-intrinsic (SI) and compensated high resistivity semiconductors. It was found that the enhanced electric field around the contact edges may cause about twofold increase in the total contact current. For contact radii larger than the device thickness and nano scale contacts the impact is considerably reduced. In nanoscale contacts the edge effect does not control the electric field under the entire contact, but rather decreases. The introduction of velocity saturation model has a limited impact, and only in compensated semiconductors.

  15. Metric conversion: Future progress depends upon private sector and public support. Report to Congressional requesters

    NASA Astrophysics Data System (ADS)

    1994-01-01

    In reviewing federal metric conversion (metrication) activities, the General Accounting Office (GAO) evaluated federal agency activities in (1) establishing metric guidelines and preparing reports on the transition, (2) using the metric system in procurements, (3) using the metric system in grants and other business activities, and (4) dealing with private sector and public attitudes toward conversion. Since 1990, federal preparations for metric conversion have advanced dramatically, with more than 30 agencies having developed some combination of guidelines, transition plans, and progress reports that indicate a substantially greater commitment to metrication. However, they are still facing serious difficulties in putting their plans into practice. These difficulties include a procurement environment in which most products are nonmetric and in which federal agencies represent too small a share of the total market to stimulate private sector conversion. Mixed progress has been made toward metric conversion in the areas of federal grants and other business activities. Grants for research require the use of the metric system, but such a commitment has not been made for grants in other areas, such as housing and education. Agencies that undertake other business-related activities, such as federal programs involving farmers or highway signs, are concerned about private sector and public resistance to conversion. Now that most agencies have made significant progress in preparing for metric conversion, a broader national dialogue between the government, the private sector, and the public is needed to discuss the next steps in decision-making about metric conversion.

  16. Perpetuating Effects of Androgen Deficiency on Insulin-resistance

    PubMed Central

    Cameron, Judy L.; Jain, Ruhee; Rais, Maham; White, Ashley E.; Beer, Tomasz M.; Kievit, Paul; Winters-Stone, Kerri; Messaoudi, Ilhem; Varlamov, Oleg

    2016-01-01

    Background/Objectives Androgen deprivation therapy (ADT) is commonly used for treatment of prostate cancer, but is associated with side effects such as sarcopenia and insulin resistance. The role of lifestyle factors such as diet and exercise on insulin sensitivity and body composition in testosterone-deficient males is poorly understood. The aim of the present study was to examine the relationships between androgen status, diet, and insulin sensitivity. Subjects/Methods Middle-aged (11–12-yo) intact and orchidectomized male rhesus macaques were maintained for two months on a standard chow diet, and then exposed for six months to a Western-style, high-fat/calorie-dense diet (WSD) followed by four months of caloric restriction (CR). Body composition, insulin sensitivity, physical activity, serum cytokine levels, and adipose biopsies were evaluated before and after each dietary intervention. Results Both intact and orchidectomized animals gained similar proportions of body fat, developed visceral and subcutaneous adipocyte hypertrophy, and became insulin resistant in response to the WSD. CR reduced body fat in both groups, but reversed insulin resistance only in intact animals. Orchidectomized animals displayed progressive sarcopenia, which persisted after the switch to CR. Androgen deficiency was associated with increased levels of interleukin-6 and macrophage-derived chemokine (CCL22), both of which were elevated during CR. Physical activity levels showed a negative correlation with body fat and insulin sensitivity. Conclusion Androgen deficiency exacerbated the negative metabolic side effects of the WSD, such that CR alone was not sufficient to improve altered insulin sensitivity, suggesting that ADT patients will require additional interventions to reverse insulin resistance and sarcopenia. PMID:27534842

  17. The correlation of metrics in complex networks with applications in functional brain networks

    NASA Astrophysics Data System (ADS)

    Li, C.; Wang, H.; de Haan, W.; Stam, C. J.; Van Mieghem, P.

    2011-11-01

    An increasing number of network metrics have been applied in network analysis. If metric relations were known better, we could more effectively characterize networks by a small set of metrics to discover the association between network properties/metrics and network functioning. In this paper, we investigate the linear correlation coefficients between widely studied network metrics in three network models (Bárabasi-Albert graphs, Erdös-Rényi random graphs and Watts-Strogatz small-world graphs) as well as in functional brain networks of healthy subjects. The metric correlations, which we have observed and theoretically explained, motivate us to propose a small representative set of metrics by including only one metric from each subset of mutually strongly dependent metrics. The following contributions are considered important. (a) A network with a given degree distribution can indeed be characterized by a small representative set of metrics. (b) Unweighted networks, which are obtained from weighted functional brain networks with a fixed threshold, and Erdös-Rényi random graphs follow a similar degree distribution. Moreover, their metric correlations and the resultant representative metrics are similar as well. This verifies the influence of degree distribution on metric correlations. (c) Most metric correlations can be explained analytically. (d) Interestingly, the most studied metrics so far, the average shortest path length and the clustering coefficient, are strongly correlated and, thus, redundant. Whereas spectral metrics, though only studied recently in the context of complex networks, seem to be essential in network characterizations. This representative set of metrics tends to both sufficiently and effectively characterize networks with a given degree distribution. In the study of a specific network, however, we have to at least consider the representative set so that important network properties will not be neglected.

  18. Agile Metrics: Progress Monitoring of Agile Contractors

    DTIC Science & Technology

    2014-01-01

    can be tailored to leverage the iterative nature of Agile meth- ods. Using optional contract funding lines or indefinite delivery indefinite quantity... naturally created during the execution of the Agile implementation. In the following paragraphs, we identify issues to consider in building an Agile...employing Agile methods [Hartman 2006]. Be prepared to mine and effectively use the metrics data that naturally occur in typical Ag- ile teams. In

  19. To Resist or Not to Resist? The Effect of Context and Crime Characteristics on Sex Offenders' Reaction to Victim Resistance

    ERIC Educational Resources Information Center

    Balemba, Samantha; Beauregard, Eric; Mieczkowski, Tom

    2012-01-01

    Circumstances under which a sexual assault takes place and how these circumstances affect offenders' reactions to victim resistance are not well understood. Previous studies have not thoroughly examined the interactions that take place between situational factors and resistance. Using a combination of logistic regression and Chi-square Automatic…

  20. Non-metric chaotic inflation

    SciTech Connect

    Enqvist, Kari; Koivisto, Tomi; Rigopoulos, Gerasimos E-mail: T.S.Koivisto@astro.uio.no

    2012-05-01

    We consider inflation within the context of what is arguably the simplest non-metric extension of Einstein gravity. There non-metricity is described by a single graviscalar field with a non-minimal kinetic coupling to the inflaton field Ψ, parameterized by a single parameter γ. There is a simple equivalent description in terms of a massless field and an inflaton with a modified potential. We discuss the implications of non-metricity for chaotic inflation and find that it significantly alters the inflaton dynamics for field values Ψ∼>M{sub P}/γ, dramatically changing the qualitative behaviour in this regime. In the equivalent single-field description this is described as a cuspy potential that forms of barrier beyond which the inflation becomes a ghost field. This imposes an upper bound on the possible number of e-folds. For the simplest chaotic inflation models, the spectral index and the tensor-to-scalar ratio receive small corrections dependent on the non-metricity parameter. We also argue that significant post-inflationary non-metricity may be generated.

  1. Metrics for Occupations. Information Series No. 118.

    ERIC Educational Resources Information Center

    Peterson, John C.

    The metric system is discussed in this information analysis paper with regard to its history, a rationale for the United States' adoption of the metric system, a brief overview of the basic units of the metric system, examples of how the metric system will be used in different occupations, and recommendations for research and development. The…

  2. Effect of cements on fracture resistance of monolithic zirconia crowns

    PubMed Central

    Nakamura, Keisuke; Mouhat, Mathieu; Nergård, John Magnus; Lægreid, Solveig Jenssen; Kanno, Taro; Milleding, Percy; Örtengren, Ulf

    2016-01-01

    Abstract Objectives The present study investigated the effect of cements on fracture resistance of monolithic zirconia crowns in relation to their compressive strength. Materials and methods Four different cements were tested: zinc phosphate cement (ZPC), glass-ionomer cement (GIC), self-adhesive resin-based cement (SRC) and resin-based cement (RC). RC was used in both dual cure mode (RC-D) and chemical cure mode (RC-C). First, the compressive strength of each cement was tested according to a standard (ISO 9917-1:2004). Second, load-to-failure test was performed to analyze the crown fracture resistance. CAD/CAM-produced monolithic zirconia crowns with a minimal thickness of 0.5 mm were prepared and cemented to dies with each cement. The crown–die samples were loaded until fracture. Results The compressive strength of SRC, RC-D and RC-C was significantly higher than those of ZPC and GIC (p < 0.05). However, there was no significant difference in the fracture load of the crown between the groups. Conclusion The values achieved in the load-to-failure test suggest that monolithic zirconia crowns with a minimal thickness of 0.5 mm may have good resistance against fracture regardless of types of cements. PMID:27335900

  3. Enhanced oxidation resistance of active nanostructures via dynamic size effect

    PubMed Central

    Liu, Yun; Yang, Fan; Zhang, Yi; Xiao, Jianping; Yu, Liang; Liu, Qingfei; Ning, Yanxiao; Zhou, Zhiwen; Chen, Hao; Huang, Wugen; Liu, Ping; Bao, Xinhe

    2017-01-01

    A major challenge limiting the practical applications of nanomaterials is that the activities of nanostructures (NSs) increase with reduced size, often sacrificing their stability in the chemical environment. Under oxidative conditions, NSs with smaller sizes and higher defect densities are commonly expected to oxidize more easily, since high-concentration defects can facilitate oxidation by enhancing the reactivity with O2 and providing a fast channel for oxygen incorporation. Here, using FeO NSs as an example, we show to the contrary, that reducing the size of active NSs can drastically increase their oxidation resistance. A maximum oxidation resistance is found for FeO NSs with dimensions below 3.2 nm. Rather than being determined by the structure or electronic properties of active sites, the enhanced oxidation resistance originates from the size-dependent structural dynamics of FeO NSs in O2. We find this dynamic size effect to govern the chemical properties of active NSs. PMID:28223687

  4. Synergistic effects of resistance training and protein intake: practical aspects.

    PubMed

    Guimarães-Ferreira, Lucas; Cholewa, Jason Michael; Naimo, Marshall Alan; Zhi, X I A; Magagnin, Daiane; de Sá, Rafaele Bis Dal Ponte; Streck, Emilio Luiz; Teixeira, Tamiris da Silva; Zanchi, Nelo Eidy

    2014-10-01

    Resistance training is a potent stimulus to increase skeletal muscle mass. The muscle protein accretion process depends on a robust synergistic action between protein intake and overload. The intake of protein after resistance training increases plasma amino acids, which results in the activation of signaling molecules leading to increased muscle protein synthesis (MPS) and muscle hypertrophy. Although both essential and non-essential amino acids are necessary for hypertrophy, the intake of free L-leucine or high-leucine whole proteins has been specifically shown to increase the initiation of translation that is essential for elevated MPS. The literature supports the use of protein intake following resistance-training sessions to enhance MPS; however, less understood are the effects of different protein sources and timing protocols on MPS. The sum of the adaptions from each individual training session is essential to muscle hypertrophy, and thus highlights the importance of an optimal supplementation protocol. The aim of this review is to present recent findings reported in the literature and to discuss the practical application of these results. In that light, new speculations and questions will arise that may direct future investigations. The information and recommendations generated in this review should be of benefit to clinical dietitians as well as those engaged in sports.

  5. Resistance to change and the law of effect

    PubMed Central

    Harper, David N.; McLean, Anthony P.

    1992-01-01

    Three experiments using multiple schedules of reinforcement explored the implications of resistance-to-change findings for the response-reinforcer relation described by the law of effect, using both steady-state responding and responding recorded in the first few sessions of conditions. In Experiment 1, when response-independent reinforcement was increased during a third component, response rate in Components 1 and 2 decreased. This response-rate reduction was proportionately greater in a component in which reinforcer magnitude was small (2-s access to wheat) than in the component in which it was large (6-s access to wheat). However, when reinforcer rates in the two components were varied together in Experiments 2 and 3, response-rate change was the same regardless of the magnitude of reinforcers used in the two components, so that sensitivity of response rates to reinforcer rates (Experiment 2) and of response-rate ratios to reinforcer-rate ratios (Experiment 3) was unaffected by the magnitude of the reinforcers. Therefore, the principles determining resistance to change, described by behavioral momentum theory, seem not to apply when the source of behavior change is the variation of reinforcement contingencies that maintain the behavior. The use of extinction as a manipulation to study resistance to change is questioned. PMID:16812656

  6. A parallel variable metric optimization algorithm

    NASA Technical Reports Server (NTRS)

    Straeter, T. A.

    1973-01-01

    An algorithm, designed to exploit the parallel computing or vector streaming (pipeline) capabilities of computers is presented. When p is the degree of parallelism, then one cycle of the parallel variable metric algorithm is defined as follows: first, the function and its gradient are computed in parallel at p different values of the independent variable; then the metric is modified by p rank-one corrections; and finally, a single univariant minimization is carried out in the Newton-like direction. Several properties of this algorithm are established. The convergence of the iterates to the solution is proved for a quadratic functional on a real separable Hilbert space. For a finite-dimensional space the convergence is in one cycle when p equals the dimension of the space. Results of numerical experiments indicate that the new algorithm will exploit parallel or pipeline computing capabilities to effect faster convergence than serial techniques.

  7. Obtaining the metric of our Universe

    NASA Astrophysics Data System (ADS)

    Jacobs, Mark W.; Linder, Eric V.; Wagoner, Robert V.

    1992-05-01

    We formulate a method for solving the gravitational field equations for perturbations to a Friedmann-Robertson-Walker metric, which does not depend on any kind of averaging procedure or make any a priori assumptions about the magnitude of fluctuations in the matter variables. We present a Green's function for obtaining the effective potential which characterizes the metric perturbations directly from the (possibly large) density fluctuations, and describe the application to astrophysical observations, for example, the angular-diameter distance-versus-redshift relation. The results do not assume a particular model for the formation of structure in the matter distribution, and are valid everywhere in our Universe outside of strong-field regions (e.g., black holes).

  8. On the Kähler metrics over Symd(X)

    NASA Astrophysics Data System (ADS)

    Aryasomayajula, Anilatmaja; Biswas, Indranil; Morye, Archana S.; Sengupta, Tathagata

    2016-12-01

    Let X be a compact connected Riemann surface of genus g, with g ≥ 2. For each d < η(X) , where η(X) is the gonality of X, the symmetric product Symd(X) embeds into Picd(X) by sending an effective divisor of degree d to the corresponding holomorphic line bundle. Therefore, the restriction of the flat Kähler metric on Picd(X) is a Kähler metric on Symd(X) . We investigate this Kähler metric on Symd(X) . In particular, we estimate it is Bergman kernel. We also prove that any holomorphic automorphism of Symd(X) is an isometry.

  9. Boundary effects on the magnetohydrodynamic stability of a resistive plasma

    NASA Astrophysics Data System (ADS)

    Velli, M.; Hood, A. W.; Einaudi, G.

    1990-02-01

    A general method for studying the resistive MHD stability of plasma configurations where boundary effects are of crucial importance and can be expressed as additional constraints on a periodic system is presented and applied to the case of line-tied cylindrically symmetric coronal loops. The eigenvalue equations obtained are a generalization of the Freidberg and Hewett equations, to which they reduce when the loop length is made infinite. An application to tearing modes is described which shows that in a finite geometry, tearing takes place at the center of the configuration, corresponding to the vertex of coronal loops. Applications to other configurations of astrophysical interest are described.

  10. The Effect of Resistance on Rocket Injector Acoustics

    NASA Technical Reports Server (NTRS)

    Morgan, C. J.

    2015-01-01

    Combustion instability, where unsteady heat release couples with acoustic modes, has long been an area of concern in liquid rocket engines. Accurate modeling of the acoustic normal modes of the combustion chamber is important to understanding and preventing combustion instability. This study evaluates the effect of injector resistance on the mode shapes and complex eigen-frequencies of an injector/combustion chamber system by defining a high Mach-flow form of the convective wave equation (see Eq. 1) in COMSOL Multiphysics' Coefficient Form PDE Mathematics Module.

  11. Kerr-Schild–Kundt metrics are universal

    NASA Astrophysics Data System (ADS)

    Gürses, Metin; Çağrı Şişman, Tahsin; Tekin, Bayram

    2017-04-01

    We define (non-Einsteinian) universal metrics as the metrics that solve the source-free covariant field equations of generic gravity theories. Here, extending the rather scarce family of universal metrics known in the literature, we show that the Kerr-Schild–Kundt class of metrics are universal. Besides being interesting on their own, these metrics can provide consistent backgrounds for quantum field theory at extremely high energies.

  12. Effect of movement velocity during resistance training on neuromuscular performance.

    PubMed

    Pareja-Blanco, F; Rodríguez-Rosell, D; Sánchez-Medina, L; Gorostiaga, E M; González-Badillo, J J

    2014-10-01

    This study aimed to compare the effect on neuromuscular performance of 2 isoinertial resistance training programs that differed only in actual repetition velocity: maximal intended (MaxV) vs. half-maximal (HalfV) concentric velocity. 21 resistance-trained young men were randomly assigned to a MaxV (n=10) or HalfV (n=11) group and trained for 6 weeks using the full squat exercise. A complementary study (n=8) described the acute metabolic and mechanical response to the protocols used. MaxV training resulted in a likely more beneficial effect than HalfV on squat performance: maximum strength (ES: 0.94 vs. 0.54), velocity developed against all (ES: 1.76 vs. 0.88), light (ES: 1.76 vs. 0.75) and heavy (ES: 2.03 vs. 1.64) loads common to pre- and post-tests, and CMJ height (ES: 0.63 vs. 0.15). The effect on 20-m sprint was unclear, however. Both groups attained the greatest improvements in squat performance at their training velocities. Movement velocity seemed to be of greater importance than time under tension for inducing strength adaptations. Slightly higher metabolic stress (blood lactate and ammonia) and CMJ height loss were found for MaxV vs. HalfV, while metabolite levels were low to moderate for both conditions. MaxV may provide a superior stimulus for inducing adaptations directed towards improving athletic performance.

  13. Reliability of in-stream retention metrics

    NASA Astrophysics Data System (ADS)

    Savickis, Jevgenijs; Zaramella, Mattia; Marion, Andrea

    2016-04-01

    The temporary solute retention within transient storage zones (TSZs) has been shown to have a large effect on the transport of solute. This retention can significantly increase the overall in-stream residence time and as consequence increase the contact time of solute with aquatic interfaces (biota, sediment) and living species. An important question that arises is whether the currently available metrics adequately represent retention mechanism. This work attempts to investigate the reliability of two existing measures, the hydrological retention factor (Rh) and the fraction of median travel time due to transient storage zone (Fmed200). For this purpose, five conservative tracer tests were conducted in four European streams with distinct morphological, sediment composition, vegetation and hydraulic characteristics. The obtained breakthrough curves (BTCs) were used to derive storage zone parameters (storage zone area, storage zone exchange coefficient and mean residence time), which then were used for comparison and in the metric expressions. The storage zone parameters were computed using a single TSZ model OTIS-P and a multiple TSZ model STIR. The STIR model was applied to BTCs as an additional tool to separate TSZs into short timescale (ST) and long timescale (LT). The study results reveal correlation between Fmed200 and LT residence time T2 values, where the streams with the lowest Fmed200 (0.01-0.96) have the smallest long timescale storage zones T2 values, ranging from 912 s to 1402 s. The findings also demonstrate an influence of discharge rate on both retention metrics. The greatest Fmed200 (6.19) and Rh (0.938) values are calculated for the streams with low discharge rates (0.08-0.10 m3s-1) and a relatively high ST storage zone residence times T1 (159 s to 351 s). Results show that the Fmed200 and Rh metrics are strongly affected by the short timescale transient storage zones, whereas the LT storage zones (hyporheic) effects are not taken into account.

  14. Thermodynamic Metrics and Optimal Paths

    SciTech Connect

    Sivak, David; Crooks, Gavin

    2012-05-08

    A fundamental problem in modern thermodynamics is how a molecular-scale machine performs useful work, while operating away from thermal equilibrium without excessive dissipation. To this end, we derive a friction tensor that induces a Riemannian manifold on the space of thermodynamic states. Within the linear-response regime, this metric structure controls the dissipation of finite-time transformations, and bestows optimal protocols with many useful properties. We discuss the connection to the existing thermodynamic length formalism, and demonstrate the utility of this metric by solving for optimal control parameter protocols in a simple nonequilibrium model.

  15. The flexibility of optical metrics

    NASA Astrophysics Data System (ADS)

    Bittencourt, Eduardo; Pereira, Jonas P.; Smolyaninov, Igor I.; Smolyaninova, Vera N.

    2016-08-01

    We firstly revisit the importance, naturalness and limitations of the so-called optical metrics for describing the propagation of light rays in the limit of geometric optics. We then exemplify their flexibility and nontriviality in some nonlinear material media and in the context of nonlinear theories of the electromagnetism, both in the presence of curved backgrounds, where optical metrics could be flat and inaccessible regions for the propagation of photons could be conceived, respectively. Finally, we underline and discuss the relevance and potential applications of our analyses in a broad sense, ranging from material media to compact astrophysical systems.

  16. Separable metrics and radiating stars

    NASA Astrophysics Data System (ADS)

    Abebe, G. Z.; Maharaj, S. D.

    2017-01-01

    We study the junction condition relating the pressure to heat flux at the boundary of an accelerating and expanding spherically symmetric radiating star. We transform the junction condition to an ordinary differential equation by making a separability assumption on the metric functions in the space-time variables. The condition of separability on the metric functions yields several new exact solutions. A class of shear-free models is found which contains a linear equation of state and generalizes a previously obtained model. Four new shearing models are obtained; all the gravitational potentials can be written explicitly. A brief physical analysis indicates that the matter variables are well behaved.

  17. Economic Metrics for Commercial Reusable Space Transportation Systems

    NASA Technical Reports Server (NTRS)

    Shaw, Eric J.; Hamaker, Joseph (Technical Monitor)

    2000-01-01

    The success of any effort depends upon the effective initial definition of its purpose, in terms of the needs to be satisfied and the goals to be fulfilled. If the desired product is "A System" that is well-characterized, these high-level need and goal statements can be transformed into system requirements by traditional systems engineering techniques. The satisfaction of well-designed requirements can be tracked by fairly straightforward cost, schedule, and technical performance metrics. Unfortunately, some types of efforts, including those that NASA terms "Programs," tend to resist application of traditional systems engineering practices. In the NASA hierarchy of efforts, a "Program" is often an ongoing effort with broad, high-level goals and objectives. A NASA "project" is a finite effort, in terms of budget and schedule, that usually produces or involves one System. Programs usually contain more than one project and thus more than one System. Special care must be taken in the formulation of NASA Programs and their projects, to ensure that lower-level project requirements are traceable to top-level Program goals, feasible with the given cost and schedule constraints, and measurable against top-level goals. NASA Programs and projects are tasked to identify the advancement of technology as an explicit goal, which introduces more complicating factors. The justification for funding of technology development may be based on the technology's applicability to more than one System, Systems outside that Program or even external to NASA. Application of systems engineering to broad-based technology development, leading to effective measurement of the benefits, can be valid, but it requires that potential beneficiary Systems be organized into a hierarchical structure, creating a "system of Systems." In addition, these Systems evolve with the successful application of the technology, which creates the necessity for evolution of the benefit metrics to reflect the changing

  18. The effect of electrical conductivity on pore resistance and electroporation

    NASA Astrophysics Data System (ADS)

    Li, Jianbo; Lin, Hao

    2008-11-01

    Electroporation is an elegant means to gain access to the cytoplasm, and to deliver molecules into the cell while simultaneously maintaining viability and functionality. In this technique, an applied electric pulse transiently permeabilizes the cell membrane, through which biologically active agents such as DNA, RNA, and amino acids can enter the cell, and perform tasks such as gene and cancer therapy. Despite wide applications, current electroporation technologies fall short of desired efficiency and reliability, in part due to the lack of fundamental understanding and quantitative modeling tools. This work focuses on the modeling of cell membrane conductance due to the formation of aqueous conducting pores. An analytical expression is developed to determine effective pore resistance as a function of the membrane thickness, pore size, and intracellular and extracellular conductivities. The availability of this expression avoids empirical or ad hoc specification of the conductivity of the pore-filling solution which was adopted in previous works. Such pore resistance model is then incorporated into a whole-cell electroporation simulation to investigate the effect of conductivity ratio on membrane permeabilization. The results reveal that the degree of permeabilization strongly depends on the specific values of the extracellular and intracellular conductivities.

  19. Bergman kernel, balanced metrics and black holes

    NASA Astrophysics Data System (ADS)

    Klevtsov, Semyon

    In this thesis we explore the connections between the Kahler geometry and Landau levels on compact manifolds. We rederive the expansion of the Bergman kernel on Kahler manifolds developed by Tian, Yau, Zelditch, Lu and Catlin, using path integral and perturbation theory. The physics interpretation of this result is as an expansion of the projector of wavefunctions on the lowest Landau level, in the special case that the magnetic field is proportional to the Kahler form. This is a geometric expansion, somewhat similar to the DeWitt-Seeley-Gilkey short time expansion for the heat kernel, but in this case describing the long time limit, without depending on supersymmetry. We also generalize this expansion to supersymmetric quantum mechanics and more general magnetic fields, and explore its applications. These include the quantum Hall effect in curved space, the balanced metrics and Kahler gravity. In particular, we conjecture that for a probe in a BPS black hole in type II strings compactified on Calabi-Yau manifolds, the moduli space metric is the balanced metric.

  20. Effect of Coffee and Caffeine Ingestion on Resistance Exercise Performance.

    PubMed

    Richardson, Darren L; Clarke, Neil D

    2016-10-01

    Richardson, DL and Clarke, ND. Effect of coffee and caffeine ingestion on resistance exercise performance. J Strength Cond Res 30(10): 2892-2900, 2016-The aim of the present study was to determine the effect of ingesting caffeine dose-matched anhydrous caffeine, coffee, or decaffeinated coffee plus anhydrous caffeine during resistance exercise on performance. Nine resistance-trained men (mean ± SD: age, 24 ± 2 years; weight, 84 ± 8 kg; height, 180 ± 8 cm) completed a squat and bench press exercise protocol at 60% 1 repetition maximum until failure on 5 occasions consuming 0.15 g·kg caffeinated coffee (COF), 0.15 g·kg decaffeinated coffee (DEC), 0.15 g·kg decaffeinated coffee plus 5 mg·kg anhydrous caffeine (D + C), 5 mg·kg anhydrous caffeine (CAF), or a placebo (PLA). Felt arousal and rating of perceived exertion (RPE) were used to assess perceptual variables and heart rate (HR) to assess physiological responses between trials. There were significant differences in total weight lifted for the squat between conditions (p < 0.01; (Equation is included in full-text article.)= 0.54) with a greater amount lifted during D + C compared with DEC (p < 0.01), CAF (p ≤ 0.05), and PLA (p ≤ 0.05) conditions. Total weight lifted during the COF condition was significantly greater than that lifted under PLA (p < 0.01), although not significantly greater than the amount of weight lifted during the DEC condition (p = 0.082). No significant differences were observed in total weight lifted in the bench press protocol between conditions (p = 0.186; (Equation is included in full-text article.)= 0.17). Significant differences in HR (p < 0.01; (Equation is included in full-text article.)= 0.39) but not RPE (squat: p = 0.690; (Equation is included in full-text article.)= 0.07; bench press: p = 0.165; (Equation is included in full-text article.)= 0.18) and felt arousal (p = 0.056; (Equation is included in full-text article.)= 0.24) were observed between conditions. Coffee and

  1. New metrics for blog mining

    NASA Astrophysics Data System (ADS)

    Ulicny, Brian; Baclawski, Ken; Magnus, Amy

    2007-04-01

    Blogs represent an important new arena for knowledge discovery in open source intelligence gathering. Bloggers are a vast network of human (and sometimes non-human) information sources monitoring important local and global events, and other blogs, for items of interest upon which they comment. Increasingly, issues erupt from the blog world and into the real world. In order to monitor blogging about important events, we must develop models and metrics that represent blogs correctly. The structure of blogs requires new techniques for evaluating such metrics as the relevance, specificity, credibility and timeliness of blog entries. Techniques that have been developed for standard information retrieval purposes (e.g. Google's PageRank) are suboptimal when applied to blogs because of their high degree of exophoricity, quotation, brevity, and rapidity of update. In this paper, we offer new metrics related for blog entry relevance, specificity, timeliness and credibility that we are implementing in a blog search and analysis tool for international blogs. This tools utilizes new blog-specific metrics and techniques for extracting the necessary information from blog entries automatically, using some shallow natural language processing techniques supported by background knowledge captured in domain-specific ontologies.

  2. Metrication and the Technical Teacher

    ERIC Educational Resources Information Center

    Irving, Michael

    1975-01-01

    The conclusion of the two-part feature on the S1 metric (International System of Units) reviews the basics and some of the rules technical teachers need to know in order to prepare their students for the changing world. (Author)

  3. Metrics in Education - Resource Materials.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Div. of Curriculum Development.

    This publication contains materials suitable for reproduction as transparencies or as classroom handouts. These metric materials may be used in a variety of occupational and practical arts courses. The format of the materials is in large print, some with humorous drawing; details of drawings and charts are easy to read. Introductory pages deal…

  4. Metric-Free Distributional Comparisons.

    ERIC Educational Resources Information Center

    Haertel, Edward H.; And Others

    Two methods are presented for comparing distributions, such as achievement test score distributions, for distinctly different groups of persons in such a way that the comparison will not be influenced by the particular metric of the test being used. Both methods use percentile scores. One method, attributed to Flanagan, fits a straight line to the…

  5. Guidelines for Teaching Metric Concepts.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison.

    The primary purpose of these guidelines is to provide teachers and other decision-makers with a suggested framework within which sound planning for metric education can be done. Student behavioral objectives are listed by topic. Each objective is coded to indicate grade level, topic, and objective number. A chart is provided to show a kindergarten…

  6. Improving an Imperfect Metric System

    ERIC Educational Resources Information Center

    Frasier, E. Lewis

    1974-01-01

    Suggests some improvements and additional units necessary for the International Metric System to expand its use to all measureable entities and defined quantities, especially in the measurement of time and angles. Included are tables of proposed unit systems in contrast with the presently available systems. (CC)

  7. Metric Measurement: Grades K-8.

    ERIC Educational Resources Information Center

    Instructional Objectives Exchange, Los Angeles, CA.

    This collection is comprised of 63 objectives and corresponding sample test items for evaluation of students in grades K-8. Correct answers or criteria for judging the adequacy of student responses are provided. Major categories in the collection are: (1) preparing to use the metric system--decimal and fractional notation; (2) measurement--length,…

  8. Psychotropic placebos create resistance to the misinformation effect.

    PubMed

    Clifasefi, Seema L; Garry, Maryanne; Harper, David N; Sharman, Stefanie J; Sutherland, Rachel

    2007-02-01

    Can a placebo for a psychotropic drug help participants resist the misinformation effect? To answer this question, we gave participants a mixture of baking soda and water and told half of them that the mixture was a cognition-enhancing drug called R273 and told the other half that it was an inactive version of the drug. Shortly thereafter, all participants took part in a three-stage misinformation experiment. Compared with participants who were told that they had taken the placebo, the participants who were told that they had taken the drug reported improved cognitive abilities and were less susceptible to the misinformation effect. We provide source-monitoring and mindfulness accounts of our findings.

  9. Semantic Metrics for Analysis of Software

    NASA Technical Reports Server (NTRS)

    Etzkorn, Letha H.; Cox, Glenn W.; Farrington, Phil; Utley, Dawn R.; Ghalston, Sampson; Stein, Cara

    2005-01-01

    A recently conceived suite of object-oriented software metrics focus is on semantic aspects of software, in contradistinction to traditional software metrics, which focus on syntactic aspects of software. Semantic metrics represent a more human-oriented view of software than do syntactic metrics. The semantic metrics of a given computer program are calculated by use of the output of a knowledge-based analysis of the program, and are substantially more representative of software quality and more readily comprehensible from a human perspective than are the syntactic metrics.

  10. The drug resistance strategies intervention: program effects on substance use.

    PubMed

    Hecht, Michael L; Graham, John W; Elek, Elvira

    2006-01-01

    This study evaluates the Drug Resistance Strategies (DRS) project, a culturally grounded, communication-based substance use prevention program implemented in 35 middle schools in Phoenix, Arizona. The intervention consisted of 10 lessons taught by the classroom teacher that imparted the knowledge, motivation, and skills needed to resist drug offers. The evaluation used growth modeling to analyze significant differences in average postintervention substance use (alcohol, cigarettes, and marijuana) and growth of use over the course of the study. The study involved 6,298 seventh graders (65% Mexican/Mexican American) who responded to at least 1 of 4 questionnaires (1 pretest and 3 follow-up measures). When compared to a control group, the DRS intervention appeared to significantly limit the increase in the number of students reporting recent substance use, especially alcohol and marijuana use. The multicultural version of the curriculum proved most broadly effective, followed by the version targeting Mexican American youth. The development of a culturally grounded prevention curriculum for Mexican American youth expands the population being served by interventions. Moreover, the success of the multicultural curriculum version, which has the broadest application, provides particular promise, and the article demonstrates how a growth modeling approach can be used to evaluate a communication-based intervention by analyzing changes over time rather than differences between the pretest and posttest scores.

  11. Resistivity and thickness effects in dendritic web silicon solar cells

    NASA Technical Reports Server (NTRS)

    Meier, D. L.; Hwang, J. M.; Greggi, J.; Campbell, R. B.

    1987-01-01

    The decrease of minority carrier lifetime as resistivity decreases in dendritic-web silicon solar cells is addressed. This variation is shown to be consistent with the presence of defect levels in the bandgap which arise from extended defects in the web material. The extended defects are oxide precipitates (SiOx) and the dislocation cores they decorate. Sensitivity to this background distribution of defect levels increases with doping because the Fermi level moves closer to the majority carrier band edge. For high-resistivity dendritic-web silicon, which has a low concentration of these extended defects, cell efficiencies as high as 16.6 percent (4 sq cm, 40 ohm-cm boron-doped base, AM1.5 global, 100 mW/sq cm, 25 C JPL LAPSS1 measurement) and a corresponding electron lifetime of 38 microsec have been obtained. Thickness effects occur in bifacial cell designs and in designs which use light trapping. In some cases, the dislocation/precipitate defect can be passivated through the full thickness of web cells by hydrogen ion implantation.

  12. The Effects of Manual Resistance Training on Fitness in Adolescents

    PubMed Central

    Dorgo, Sandor; King, George A.; Candelaria, Norma; Bader, Julia O.; Brickey, Gregory D.; Adams, Carolyn E.

    2010-01-01

    Manual Resistance Training (MRT), an alternative to traditional resistance training, requires minimal equipment and may be effective when applied in school-based physical education (PE) classes. The purpose of this study was to document the physical changes in adolescents (N = 222) using MRT in school-based PE settings. Six fitness tests from the Fitnessgram assessment tool were selected to assess students' cardiovascular and muscular fitness and skin-fold tests were used to assess body composition. One Control and two Experimental Groups were defined. The Control group of students (N = 129) attended regular PE classes. One Experimental group (N = 63) attended PE that was complemented by the MRT system. A second Experiment group (N = 30) attended PE complemented by MRT and cardiovascular endurance training. Using the selected Fitnessgram tests post-test measurements were done after 9 and 18 weeks of PE. At baseline, there were no significant differences between the three groups for most measures. Compared to baseline, experimental groups improved significantly in all six fitness measures and showed more improvements than the Control group in most fitness measures both at 9 and 18 weeks. None of the groups showed significant improvement in body composition. The results documented that an MRT complemented PE program was effective in improving adolescents' muscular fitness. An 18-week combined MRT and cardiovascular endurance training program effectively improved cardiovascular and muscular fitness but was ineffective in improving adolescent body composition. An MRT based exercise session requires minimal equipment and set-up, and can be performed in a short period of time, therefore it is suitable for application in regular PE settings. PMID:19826296

  13. Effects of cementation surface modifications on fracture resistance of zirconia

    PubMed Central

    Srikanth, Ramanathan; Kosmac, Tomaz; Bona, Alvaro Della; Yin, Ling; Zhang, Yu

    2015-01-01

    Objectives To examine the effects of glass infiltration (GI) and alumina coating (AC) on the indentation flexural load and four-point bending strength of monolithic zirconia. Methods Plate-shaped (12 mm × 12 mm × 1.0 mm or 1.5 mm or 2.0 mm) and bar-shaped (4 mm × 3 mm × 25 mm) monolithic zirconia specimens were fabricated. In addition to monolithic zirconia (group Z), zirconia monoliths were glass-infiltrated or alumina-coated on their tensile surfaces to form groups ZGI and ZAC, respectively. They were also glass-infiltrated on their upper surfaces, and glass-infiltrated or alumina-coated on their lower (tensile) surfaces to make groups ZGI2 and ZAC2, respectively. For comparison, porcelain-veneered zirconia (group PVZ) and monolithic lithium disilicate glass-ceramic (group LiDi) specimens were also fabricated. The plate-shaped specimens were cemented onto a restorative composite base for Hertzian indentation using a tungsten carbide spherical indenter with a radius of 3.2 mm. Critical loads for indentation flexural fracture at the zirconia cementation surface were measured. Strengths of bar-shaped specimens were evaluated in four-point bending. Results Glass infiltration on zirconia tensile surfaces increased indentation flexural loads by 32% in Hertzian contact and flexural strength by 24% in four-point bending. Alumina coating showed no significant effect on resistance to flexural damage of zirconia. Monolithic zirconia outperformed porcelain-veneered zirconia and monolithic lithium disilicate glass-ceramics in terms of both indentation flexural load and flexural strength. Significance While both alumina coating and glass infiltration can be used to effectively modify the cementation surface of zirconia, glass infiltration can further increase the flexural fracture resistance of zirconia. PMID:25687628

  14. Conformal Gravity and the Alcubierre Warp Drive Metric

    NASA Astrophysics Data System (ADS)

    Varieschi, Gabriele; Burstein, Zily

    2013-04-01

    We present an analysis of the classic Alcubierre metric based on conformal gravity, rather than standard general relativity. The main characteristics of the resulting warp drive remain the same as in the original study by Alcubierre, namely that effective super-luminal motion is a viable outcome of the metric. We show that for particular choices of the shaping function, the Alcubierre metric in the context of conformal gravity does not violate the weak energy condition, as was the case of the original solution. In particular, the resulting warp drive does not require the use of exotic matter. Therefore, if conformal gravity is a correct extension of general relativity, super-luminal motion via an Alcubierre metric might be a realistic solution, thus allowing faster-than-light interstellar travel.

  15. Non-metric variation of the infracranial skeleton.

    PubMed Central

    Finnegan, M

    1978-01-01

    196 skeletons of known age, sex and rac from the Terry Collection were studied in order to document 30 non-metric infracranial traits. Each trait had the ability to be expressed bilaterally, although significant side dimorphism was not observed. Sex differences were statistically significant for some of the traits within a racial group, but these differences were not as pronounced as the differences generated by non-metric cranial traits in the same populations, and were not effective in all racial groups. In general, these infracranial traits show some age dependency when correlation statistics are used, but this dependency is lost when the more robust chi 2 statistic is used. These data suggest that infracranial non-metric traits may be superior to cranial non-metric traits for population comparisons. Infracranial traits may be more durable than cranial traits having regard to the nature of most archaeological material. PMID:632214

  16. Effect of Lipid Materials on Heat Resistance of Bacterial Spores

    PubMed Central

    Molin, N.; Snygg, B. G.

    1967-01-01

    The apparent heat resistance of spores of Bacillus megaterium, B. subtilis, B. cereus, B. stearothermophilus, and Clostridium botulinum type E in lipids was investigated and compared with the resistance of the spores in phosphate buffer solution. The most pronounced increase in heat resistance was noted for B. subtilis and C. botulinum type E, the increase varying with the type of lipid used. A high water content of the lipids used as heating menstruum lowered the heat resistance of the spores. Possible explanations for the high heat resistance of spores in lipids are discussed. PMID:16349757

  17. [The effect of antibacterial substances on spread resistance of bacteria].

    PubMed

    Chojecka, Agnieszka; Jakimiak, Bozenna; Röhm-Rodowald, Ewa; Podgórska, Marta

    2010-01-01

    The evaluation of influence biocides on phenomenon of spread resistance bacteria is wide discussed particularly in the medical area. Current issue is examinated mechanisms of spread bacterial resistance in the areas using antibiotics and disinfectants and in natural environment. Selection of resistance bacteria is connected with using biocides against the rules in medical care and disinfection. Biocides using in static concentrations do not act as bacteriocidal substances and contribute to survival rate of resistance bacteria. Disinfectants use correctly to the areas and in right using concentrations prevent spread of resistance bacteria.

  18. Effects of pharmacological agents on subcortical resistance shifts

    NASA Technical Reports Server (NTRS)

    Klivington, K. A.

    1975-01-01

    Microliter quantities of tetrodotoxin, tetraethylammonium chloride, and picrotoxin injected into the inferior colliculus and superior olive of unanesthetized cats differentially affect the amplitude and waveform of click-evoked potentials and evoked resistance shifts. Tetrodotoxin simultaneously reduces the negative phase of the evoked potential and eliminates the evoked resistance shift. Tetraethylammonium enhances the negative evoked potential component, presumably of postsynaptic origin, without significantly altering evoked resistance shift amplitude. Picrotoxin also enhances the negative evoked potential wave but increases evoked resistance shift amplitude. These findings implicate events associated with postsynaptic membrane depolarization in the production of the evoked resistance shift.

  19. Resistance of platelet proteins to effects of ionizing radiation

    SciTech Connect

    Prodouz, K.N.; Habraken, J.W.; Moroff, G. )

    1990-12-01

    Gamma irradiation of blood components prevents lymphocyte-induced graft-versus-host disease after transfusion in immunocompromised individuals. In this report we demonstrate the resistance of blood platelet proteins to gamma radiation-induced protein cleavage and aggregate formation when platelet concentrates were treated with a dose of 5000 rad. Results of one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis of total platelet protein and cytoskeletal protein preparations indicate that platelet proteins are neither cleaved nor cross-linked under these conditions of irradiation. These results support those of a previous study that documented the lack of any adverse effect of 5000 rad gamma radiation on in vitro platelet properties.

  20. The effect of different resistivity models on magnetotail dynamics

    NASA Technical Reports Server (NTRS)

    Lyon, J. G.; Fedder, J. A.; Huba, J. D.

    1986-01-01

    Two-dimensional, time-dependent MHD simulations of the interaction between the solar wind and the earth's magnetosphere have been performed to study magnetotail dynamics with varying forms of anomalous resistivity. In general, the resulting models conform to the neutral line model proposed for substorms with near-earth x points and high-speed tailward flows occurring in the magnetotail. However, in the case where Joule heating is included in the physical description of the system, the near-earth x point never moves far down tail, and high-speed tailward flows never stop. Only in the case where there is no Joule heating does the x point move down tail. Simultaneously, the high-speed tailward flows cease. These results indicate that the mechanism of energy dissipation can have an important effect on reconnection processes and the global magnetospheric dynamics.

  1. Testing the Effectiveness of Intervention Programs on Children's Compliance-Resisting Behaviors.

    ERIC Educational Resources Information Center

    McQuillen, Jeffrey S.; And Others

    A study examined the effectiveness of a resistance-based prevention program to increase subjects' ability to comprehend and apply resistance skills. Subjects were 30 participants in kindergarten through third grade. Fifteen subjects received resistance-based prevention training from the We Help Ourselves (WHO) program. The remaining 15 subjects…

  2. Disentangling the roles of diversity resistance and priority effects in community assembly.

    PubMed

    Viana, Duarte S; Cid, Bertha; Figuerola, Jordi; Santamaría, Luis

    2016-11-01

    The assembly of many biological communities is constrained by the resistance exerted by resident species to immigration (biotic resistance). Two important mechanisms contribute to the generation of biotic resistance: diversity resistance and priority effects. These mechanisms have been explored through theoretical models and laboratory experiments, but the importance of their interplay in the assembly of natural communities remains untested. We used a mesocosm experiment with communities of aquatic plants and zooplankton assembled from natural propagule banks to test whether and how diversity resistance, mediated by the diversity of the resident community, and priority effects, mediated by the timing of immigrants' arrival, affect the establishment of immigrant species and community diversity. In plant communities, immigration success decreased with increasing resident-species richness (diversity resistance) and arrival time (priority effects). Further, diversity resistance was stronger in communities colonized later in the season, indicating that these mechanisms interacted to reinforce biotic resistance. This interaction ultimately determined species richness and beta-diversity in plant communities. For zooplankton, in contrast, neither the diversity of resident communities nor the time of arrival affected the establishment of immigrant species. In these communities, beta-diversity was explained by species sorting, namely biotic effects mediated by plant assemblages. Our results show that the progressive buildup of communities generates an interaction between diversity resistance and priority effects that eventually determines community diversity, unless species sorting mediated by environmental filtering supersedes the effect of biotic resistance. Therefore, disentangling the mechanisms underlying biotic resistance contributes to understand how species diversity is ultimately determined.

  3. Persuasive communication: A theoretical model for changing the attitude of preservice elementary teachers toward metric conversion

    NASA Astrophysics Data System (ADS)

    Shrigley, Robert L.

    This study was based on Hovland's four-part statement, Who says what to whom with what effect, the rationale for persuasive communication, a theoretical model for modifying attitudes. Part I was a survey of 139 perservice elementary teachers from which were generated the more credible characteristics of metric instructors, a central element in the who component of Hovland's model. They were: (1) background in mathematics and science, (2) fluency in metrics, (3) capability of thinking metrically, (4) a record of excellent teaching, (5) previous teaching of metric measurement to children, (6) responsibility for teaching metric content in methods courses and (7) an open enthusiasm for metric conversion. Part II was a survey of 45 mathematics educators where belief statements were synthesized for the what component of Hovland's model. It found that math educators support metric measurement because: (1) it is consistent with our monetary system; (2) the conversion of units is easier into metric than English; (3) it is easier to teach and easier to learn than English measurement; there is less need for common fractions; (4) most nations use metric measurement; scientists have used it for decades; (5) American industry has begun to use it; (6) metric measurement will facilitate world trade and communication; and (7) American children will need it as adults; educational agencies are mandating it. With the who and what of Hovland's four-part statement defined, educational researchers now have baseline data to use in testing experimentally the effect of persuasive communication on the attitude of preservice teachers toward metrication.

  4. Evaluating the relationship between biotic and sediment metrics using mesocosms and field studies.

    PubMed

    Conroy, E; Turner, J N; Rymszewicz, A; Bruen, M; O'Sullivan, J J; Lawler, D M; Lally, H; Kelly-Quinn, M

    2016-10-15

    An ongoing research challenge is the detection of biological responses to elevated sediment and the identification of sediment-specific bioassessment metrics to evaluate these biological responses. Laboratory mesocosms and field observations in rivers in Ireland were used to evaluate the relationship between a range of biological and sediment metrics and to assess which biological metrics were best at discerning the effects of excess sediment on macroinvertebrates. Results from the mesocosm study indicated a marked decrease in the abundance of sensitive taxa with increasing sediment surface cover. % EPT (Ephemeroptera, Plecoptera, Trichoptera) and % E abundances exhibited the strongest negative correlation with sediment surface cover in the mesocosm study. The field study revealed that % EPT abundance was most closely correlated with % sediment surface cover, explaining 13% of the variance in the biological metric. Both studies revealed weaker relationships with a number of other taxonomy-based metrics including total taxon abundance, total taxon richness and moderate relationships with the Proportion of Sediment-sensitive Invertebrates metric (PSI). All trait-based metrics were poorly correlated with sediment surface cover in the field study. In terms of sediment metrics, % surface cover was more closely related to biological metrics than either re-suspendable sediment or turbidity. These results indicate that % sediment surface cover and % EPT abundance may be useful metrics for assessing the effect of excessive sediment on macroinvertebrates. However, EPT metrics may not be specific to sediment impact and therefore when applied to rivers with multiple pressures should be combined with observations on sediment cover.

  5. Metrics for Labeled Markov Systems

    NASA Technical Reports Server (NTRS)

    Desharnais, Josee; Jagadeesan, Radha; Gupta, Vineet; Panangaden, Prakash

    1999-01-01

    Partial Labeled Markov Chains are simultaneously generalizations of process algebra and of traditional Markov chains. They provide a foundation for interacting discrete probabilistic systems, the interaction being synchronization on labels as in process algebra. Existing notions of process equivalence are too sensitive to the exact probabilities of various transitions. This paper addresses contextual reasoning principles for reasoning about more robust notions of "approximate" equivalence between concurrent interacting probabilistic systems. The present results indicate that:We develop a family of metrics between partial labeled Markov chains to formalize the notion of distance between processes. We show that processes at distance zero are bisimilar. We describe a decision procedure to compute the distance between two processes. We show that reasoning about approximate equivalence can be done compositionally by showing that process combinators do not increase distance. We introduce an asymptotic metric to capture asymptotic properties of Markov chains; and show that parallel composition does not increase asymptotic distance.

  6. Fuzzy polynucleotide spaces and metrics.

    PubMed

    Nieto, Juan J; Torres, A; Georgiou, D N; Karakasidis, T E

    2006-04-01

    The study of genetic sequences is of great importance in biology and medicine. Mathematics is playing an important role in the study of genetic sequences and, generally, in bioinformatics. In this paper, we extend the work concerning the Fuzzy Polynucleotide Space (FPS) introduced in Torres, A., Nieto, J.J., 2003. The fuzzy polynucleotide Space: Basic properties. Bioinformatics 19(5); 587-592 and Nieto, J.J., Torres, A., Vazquez-Trasande, M.M. 2003. A metric space to study differences between polynucleotides. Appl. Math. Lett. 27:1289-1294: by studying distances between nucleotides and some complete genomes using several metrics. We also present new results concerning the notions of similarity, difference and equality between polynucleotides. The results are encouraging since they demonstrate how the notions of distance and similarity between polynucleotides in the FPS can be employed in the analysis of genetic material.

  7. Object-oriented productivity metrics

    NASA Technical Reports Server (NTRS)

    Connell, John L.; Eller, Nancy

    1992-01-01

    Software productivity metrics are useful for sizing and costing proposed software and for measuring development productivity. Estimating and measuring source lines of code (SLOC) has proven to be a bad idea because it encourages writing more lines of code and using lower level languages. Function Point Analysis is an improved software metric system, but it is not compatible with newer rapid prototyping and object-oriented approaches to software development. A process is presented here for counting object-oriented effort points, based on a preliminary object-oriented analysis. It is proposed that this approach is compatible with object-oriented analysis, design, programming, and rapid prototyping. Statistics gathered on actual projects are presented to validate the approach.

  8. Measuring Sustainability: Deriving Metrics From Objectives (Presentation)

    EPA Science Inventory

    The definition of 'sustain', to keep in existence, provides some insight into the metrics that are required to measure sustainability and adequately respond to assure sustainability. Keeping something in existence implies temporal and spatial contexts and requires metrics that g...

  9. Sustainability Metrics: The San Luis Basin Project

    EPA Science Inventory

    Sustainability is about promoting humanly desirable dynamic regimes of the environment. Metrics: ecological footprint, net regional product, exergy, emergy, and Fisher Information. Adaptive management: (1) metrics assess problem, (2) specific problem identified, and (3) managemen...

  10. Effects of halides on plasmid-mediated silver resistance in Escherichia coli.

    PubMed

    Gupta, A; Maynes, M; Silver, S

    1998-12-01

    Silver resistance of sensitive Escherichia coli J53 and resistance plasmid-containing J53(pMG101) was affected by halides in the growth medium. The effects of halides on Ag+ resistance were measured with AgNO3 and silver sulfadiazine, both on agar and in liquid. Low concentrations of chloride made the differences in MICs between sensitive and resistant strains larger. High concentrations of halides increased the sensitivities of both strains to Ag+.

  11. Effects of Halides on Plasmid-Mediated Silver Resistance in Escherichia coli

    PubMed Central

    Gupta, Amit; Maynes, Maria; Silver, Simon

    1998-01-01

    Silver resistance of sensitive Escherichia coli J53 and resistance plasmid-containing J53(pMG101) was affected by halides in the growth medium. The effects of halides on Ag+ resistance were measured with AgNO3 and silver sulfadiazine, both on agar and in liquid. Low concentrations of chloride made the differences in MICs between sensitive and resistant strains larger. High concentrations of halides increased the sensitivities of both strains to Ag+. PMID:9835606

  12. Science and Technology Transition Metrics

    DTIC Science & Technology

    2004-03-01

    for Research", Science, Volume 277, 1 August 1997. Kostoff, R. N., "The Use and Misuse of Citation Analysis in Research Evaluation", Scientometrics ...The Metrics of Science and Technology”. Scientometrics . 50:2. 353-361. February 2001. Kostoff, R. N., and Schaller, R. R. "Science and...37. 604-606. September 2001. Kostoff, R. N. “Citation Analysis for Research Performer Quality”. Scientometrics . 53:1. 49-71. 2002. VII

  13. Multi-Metric Sustainability Analysis

    SciTech Connect

    Cowlin, Shannon; Heimiller, Donna; Macknick, Jordan; Mann, Margaret; Pless, Jacquelyn; Munoz, David

    2014-12-01

    A readily accessible framework that allows for evaluating impacts and comparing tradeoffs among factors in energy policy, expansion planning, and investment decision making is lacking. Recognizing this, the Joint Institute for Strategic Energy Analysis (JISEA) funded an exploration of multi-metric sustainability analysis (MMSA) to provide energy decision makers with a means to make more comprehensive comparisons of energy technologies. The resulting MMSA tool lets decision makers simultaneously compare technologies and potential deployment locations.

  14. Visual metrics: discriminative power through flexibility.

    PubMed

    Janssen, T J; Blommaert, F J

    2000-01-01

    An important stage in visual processing is the quantification of optical attributes of the outside world. We argue that the metrics used for this quantification are flexible, and that this flexibility is exploited to optimise the discriminative power of the metrics. We derive mathematical expressions for such optimal metrics and show that they exhibit properties resembling well-known visual phenomena. To conclude, we discuss some of the implications of flexible metrics for visual identification.

  15. Co-delivery of multiple drug resistance inhibitors by polymer/inorganic hybrid nanoparticles to effectively reverse cancer drug resistance.

    PubMed

    Wu, Cong; Gong, Meng-Qing; Liu, Bo-Ya; Zhuo, Ren-Xi; Cheng, Si-Xue

    2017-01-01

    To effectively reverse multiple drug resistance (MDR) in tumor treatments, a functional nano-sized drug delivery system with active targeting function and pH sensitivity was prepared for the co-delivery of multiple drug resistance inhibitors. Buthionine sulfoximine (BSO) to inhibit GSH synthesis and celecoxib (CXB) to down-regulate P-gp expression were co-loaded in polymer/inorganic hybrid nanoparticles to form buthionine sulfoximine/celecoxib@biotin-heparin/heparin/calcium carbonate/calcium phosphate nanoparticles (BSO/CXB@BNP). To investigate the reversal of MDR, the drug resistant cells (MCF-7/ADR) were pretreated by the dual-inhibitor loaded nanoparticles (BSO/CXB@BNP) followed by the treatment of doxorubicin (DOX) loaded nanoparticles (DOX@BNP). The dual-inhibitor loaded nanoparticles (BSO/CXB@BNP) exhibited greatly enhanced efficiency in down-regulation of GSH and P-gp since BSO and CXB had combined effects on the reduction of GSH and P-gp in drug resistant tumor cells. As a result, BSO/CXB@BNP exhibited a significantly improved capability in reversal of MDR compared with mono-inhibitor loaded nanoparticles (CXB@BNP and BSO@BNP). As compared with free drug resistance inhibitors, delivery of drug resistance inhibitors by functional nanocarriers could obviously improve the therapeutic efficiency due to enhanced cellular uptake and increased intracellular drug accumulation. The study on immunostimulatory effects of different treatments showed that BSO/CXB@BNP treatment resulted in the lowest concentration of interleukin 10, a cytokine related to tumor development. These results suggest the nanoparticulate drug delivery platform developed in this study has promising applications in multiple drug delivery to overcome drug resistance in tumor treatments.

  16. Kinetic and resistive effects on interchange instabilities for a cylindrical model spheromak

    SciTech Connect

    Hammett, G.W.; Tang, W.M.

    1983-04-01

    The stabilizing influence of diamagnetic drift effects on ideal and resistive interchange modes is investigated. A resistive-ballooning-mode equation is derived using a kinetic theory approach and is applied to a cylindrical model spheromak equilibrium. It is found that these kinetic effects can significantly improve the ..beta.. limits for collisionless interchange stability. For the resistive modes, the diamagnetic drift terms lead to growth rates which scale linearly with resistivity and are considerably reduced in magnitude. However, the resistive interchange growth rates estimated for near-term spheromak parameters remain significant.

  17. Lensing in the McVittie metric

    NASA Astrophysics Data System (ADS)

    Piattella, Oliver F.

    2016-01-01

    We investigate the effect of the cosmological expansion on the bending of light due to an isolated pointlike mass. We adopt the McVittie metric as the model for the geometry of the lens. Assuming a constant Hubble factor, we find an analytic expression involving the bending angle, which turns out to be increased by a contribution 1 +zL, where zL is the redshift of the lens. Employing the lens equation in the thin lens approximation, we find that for Einstein ring systems, the lens mass estimation gains a correction (1 +zS)/(1 +zL) with respect to the one based on the usual formula.

  18. Kinetic effects of energetic particles on resistive MHD stability.

    PubMed

    Takahashi, R; Brennan, D P; Kim, C C

    2009-04-03

    We show that the kinetic effects of energetic particles can play a crucial role in the stability of the m/n=2/1 tearing mode in tokamaks (e.g., JET, JT-60U, and DIII-D), where the fraction of energetic particle beta(frac) is high. Using model equilibria based on DIII-D experimental reconstructions, the nonideal MHD linear stability of cases unstable to the 2/1 mode is investigated including a deltaf particle-in-cell model for the energetic particles coupled to the nonlinear 3D resistive MHD code NIMROD [C. C. Kim et al., Phys. Plasmas 15, 072507 (2008)10.1063/1.2949704]. It is observed that energetic particles have significant damping and stabilizing effects at experimentally relevant beta, beta(frac), and S, and excite a real frequency of the 2/1 mode. Extrapolation of the results is discussed for implications to JET and ITER, where the effects are projected to be significant.

  19. Application of resistivity monitoring to evaluate cement grouting effect in earth filled dam

    SciTech Connect

    Kim, Jin-Mo; Yoon, Wang-Jung

    2015-03-10

    In this paper, we applied electrical resistivity monitoring method to evaluate the cement grouting effect. There are a lot of ways to evaluate cement grouting effect. In order to do this evaluation in a great safety, high efficiency, and lower cost, resistivity monitoring is found to be the most appropriate technique. In this paper we have selected a dam site from Korea to acquire resistivity monitoring data and compare the results of inversion to estimate the cement grouting effect.

  20. Metrics for Evaluation of Student Models

    ERIC Educational Resources Information Center

    Pelanek, Radek

    2015-01-01

    Researchers use many different metrics for evaluation of performance of student models. The aim of this paper is to provide an overview of commonly used metrics, to discuss properties, advantages, and disadvantages of different metrics, to summarize current practice in educational data mining, and to provide guidance for evaluation of student…

  1. Quasi-Einstein metrics on hypersurface families

    NASA Astrophysics Data System (ADS)

    Hall, Stuart James

    2013-02-01

    We construct quasi-Einstein metrics on some hypersurface families. The hypersurfaces are circle bundles over the product of Fano, Kähler-Einstein manifolds. The quasi-Einstein metrics are related to various gradient Kähler-Ricci solitons constructed by Dancer and Wang and some Hermitian, non-Kähler, Einstein metrics constructed by Wang and Wang on the same manifolds.

  2. Measures of agreement between computation and experiment:validation metrics.

    SciTech Connect

    Barone, Matthew Franklin; Oberkampf, William Louis

    2005-08-01

    With the increasing role of computational modeling in engineering design, performance estimation, and safety assessment, improved methods are needed for comparing computational results and experimental measurements. Traditional methods of graphically comparing computational and experimental results, though valuable, are essentially qualitative. Computable measures are needed that can quantitatively compare computational and experimental results over a range of input, or control, variables and sharpen assessment of computational accuracy. This type of measure has been recently referred to as a validation metric. We discuss various features that we believe should be incorporated in a validation metric and also features that should be excluded. We develop a new validation metric that is based on the statistical concept of confidence intervals. Using this fundamental concept, we construct two specific metrics: one that requires interpolation of experimental data and one that requires regression (curve fitting) of experimental data. We apply the metrics to three example problems: thermal decomposition of a polyurethane foam, a turbulent buoyant plume of helium, and compressibility effects on the growth rate of a turbulent free-shear layer. We discuss how the present metrics are easily interpretable for assessing computational model accuracy, as well as the impact of experimental measurement uncertainty on the accuracy assessment.

  3. Adaptive Distance Metric Learning for Diffusion Tensor Image Segmentation

    PubMed Central

    Kong, Youyong; Wang, Defeng; Shi, Lin; Hui, Steve C. N.; Chu, Winnie C. W.

    2014-01-01

    High quality segmentation of diffusion tensor images (DTI) is of key interest in biomedical research and clinical application. In previous studies, most efforts have been made to construct predefined metrics for different DTI segmentation tasks. These methods require adequate prior knowledge and tuning parameters. To overcome these disadvantages, we proposed to automatically learn an adaptive distance metric by a graph based semi-supervised learning model for DTI segmentation. An original discriminative distance vector was first formulated by combining both geometry and orientation distances derived from diffusion tensors. The kernel metric over the original distance and labels of all voxels were then simultaneously optimized in a graph based semi-supervised learning approach. Finally, the optimization task was efficiently solved with an iterative gradient descent method to achieve the optimal solution. With our approach, an adaptive distance metric could be available for each specific segmentation task. Experiments on synthetic and real brain DTI datasets were performed to demonstrate the effectiveness and robustness of the proposed distance metric learning approach. The performance of our approach was compared with three classical metrics in the graph based semi-supervised learning framework. PMID:24651858

  4. Effect of resistance training on muscle use during exercise

    NASA Technical Reports Server (NTRS)

    Ploutz, Lori L.; Tesch, Per A.; Biro, Ronald L.; Dudley, Gary A.

    1994-01-01

    This study examined the effect of resistance training on exercise-induced contrast shift in magnetic resonance (MR) images. It was hypothesized that a given load could be lifted after training with less muscle showing contrast shift, thereby suggesting less muscle was used to perform the exercise. Nine males trained the left quadriceps femoris (QF) muscle 2 days/wk for 9 wk using 3-6 sets of 12 knee extensions each day. The right QF served as a control. Exercise-induced contrast shifts in MR images evoked by each of three bouts of exercise (5 sets of 10 knee extensions with a load equal to 50, 75, and 100% of the maximum pretraining load that could be lifted for 5 sets of 10 repetitions) were quantified pre- and posttraining. MR image contrast shift was quantified by determining QF cross-sectional area (CSA) showing increased spin-spin relaxation time. One repetition maximum increased 14% in the left trained QF and 7% in the right untrained QF. Left QF CSA increased 5%, with no change in right QSF CSA. Left QF CSA showing contrast shift was less after each bout of the exercise test posttraining. This was also true, to a lesser extent, for the right QF at the higher two loads. The results suggest that short-term resistance training reduces MR image contrast shift evoked by a given effort, thereby reflecting the use of less muscle to lift the load. Because this response was evident in both trained and contralateral untrained muscle, neural factors are suggested to be responsible. The consequence of this adaptation could be to increase 'stress' per unit area of active muscle during the course of training and thereby evoke hypertrophy.

  5. Resistance training vs. static stretching: effects on flexibility and strength.

    PubMed

    Morton, Sam K; Whitehead, James R; Brinkert, Ronald H; Caine, Dennis J

    2011-12-01

    Morton, SK, Whitehead, JR, Brinkert, RH, and Caine, DJ. Resistance training vs. static stretching: Effects on flexibility and strength. J Strength Cond Res 25(12): 3391-3398, 2011-The purpose of this study was to determine how full-range resistance training (RT) affected flexibility and strength compared to static stretching (SS) of the same muscle-joint complexes in untrained adults. Volunteers (n = 25) were randomized to an RT or SS training group. A group of inactive volunteers (n = 12) served as a convenience control group (CON). After pretesting hamstring extension, hip flexion and extension, shoulder extension flexibility, and peak torque of quadriceps and hamstring muscles, subjects completed 5-week SS or RT treatments in which the aim was to stretch or to strength train the same muscle-joint complexes over similar movements and ranges. Posttests of flexibility and strength were then conducted. There was no difference in hamstring flexibility, hip flexion, and hip extension improvement between RT and SS, but both were superior to CON values. There were no differences between groups on shoulder extension flexibility. The RT group was superior to the CON in knee extension peak torque, but there were no differences between groups on knee flexion peak torque. The results of this preliminary study suggest that carefully constructed full-range RT regimens can improve flexibility as well as the typical SS regimens employed in conditioning programs. Because of the potential practical significance of these results to strength and conditioning programs, further studies using true experimental designs, larger sample sizes, and longer training durations should be conducted with the aim of confirming or disproving these results.

  6. The Effective Resistance of the -Cycle Graph with Four Nearest Neighbors

    NASA Astrophysics Data System (ADS)

    Chair, Noureddine

    2014-02-01

    The exact expression for the effective resistance between any two vertices of the -cycle graph with four nearest neighbors , is given. It turns out that this expression is written in terms of the effective resistance of the -cycle graph , the square of the Fibonacci numbers, and the bisected Fibonacci numbers. As a consequence closed form formulas for the total effective resistance, the first passage time, and the mean first passage time for the simple random walk on the the -cycle graph with four nearest neighbors are obtained. Finally, a closed form formula for the effective resistance of with all first neighbors removed is obtained.

  7. Effective dominance of resistance of Spodoptera frugiperda to Bt maize and cotton varieties: implications for resistance management

    NASA Astrophysics Data System (ADS)

    Horikoshi, Renato J.; Bernardi, Daniel; Bernardi, Oderlei; Malaquias, José B.; Okuma, Daniela M.; Miraldo, Leonardo L.; Amaral, Fernando S. De A. E.; Omoto, Celso

    2016-10-01

    The resistance of fall armyworm (FAW), Spodoptera frugiperda, has been characterized to some Cry and Vip3A proteins of Bacillus thuringiensis (Bt) expressed in transgenic maize in Brazil. Here we evaluated the effective dominance of resistance based on the survival of neonates from selected Bt-resistant, heterozygous, and susceptible (Sus) strains of FAW on different Bt maize and cotton varieties. High survival of strains resistant to the Cry1F (HX-R), Cry1A.105/Cry2Ab (VT-R) and Cry1A.105/Cry2Ab/Cry1F (PW-R) proteins was detected on Herculex, YieldGard VT PRO and PowerCore maize. Our Vip3A-resistant strain (Vip-R) exhibited high survival on Herculex, Agrisure Viptera and Agrisure Viptera 3 maize. However, the heterozygous from HX-R × Sus, VT-R × Sus, PW-R × Sus and Vip-R × Sus had complete mortality on YieldGard VT PRO, PowerCore, Agrisure Viptera, and Agrisure Viptera 3, whereas the HX-R × Sus and Vip-R × Sus strains survived on Herculex maize. On Bt cotton, the HX-R, VT-R and PW-R strains exhibited high survival on Bollgard II. All resistant strains survived on WideStrike, but only PW-R and Vip-R × Sus survived on TwinLink. Our study provides useful data to aid in the understanding of the effectiveness of the refuge strategy for Insect Resistance Management of Bt plants.

  8. Effective dominance of resistance of Spodoptera frugiperda to Bt maize and cotton varieties: implications for resistance management.

    PubMed

    Horikoshi, Renato J; Bernardi, Daniel; Bernardi, Oderlei; Malaquias, José B; Okuma, Daniela M; Miraldo, Leonardo L; Amaral, Fernando S de A E; Omoto, Celso

    2016-10-10

    The resistance of fall armyworm (FAW), Spodoptera frugiperda, has been characterized to some Cry and Vip3A proteins of Bacillus thuringiensis (Bt) expressed in transgenic maize in Brazil. Here we evaluated the effective dominance of resistance based on the survival of neonates from selected Bt-resistant, heterozygous, and susceptible (Sus) strains of FAW on different Bt maize and cotton varieties. High survival of strains resistant to the Cry1F (HX-R), Cry1A.105/Cry2Ab (VT-R) and Cry1A.105/Cry2Ab/Cry1F (PW-R) proteins was detected on Herculex, YieldGard VT PRO and PowerCore maize. Our Vip3A-resistant strain (Vip-R) exhibited high survival on Herculex, Agrisure Viptera and Agrisure Viptera 3 maize. However, the heterozygous from HX-R × Sus, VT-R × Sus, PW-R × Sus and Vip-R × Sus had complete mortality on YieldGard VT PRO, PowerCore, Agrisure Viptera, and Agrisure Viptera 3, whereas the HX-R × Sus and Vip-R × Sus strains survived on Herculex maize. On Bt cotton, the HX-R, VT-R and PW-R strains exhibited high survival on Bollgard II. All resistant strains survived on WideStrike, but only PW-R and Vip-R × Sus survived on TwinLink. Our study provides useful data to aid in the understanding of the effectiveness of the refuge strategy for Insect Resistance Management of Bt plants.

  9. Effective dominance of resistance of Spodoptera frugiperda to Bt maize and cotton varieties: implications for resistance management

    PubMed Central

    Horikoshi, Renato J.; Bernardi, Daniel; Bernardi, Oderlei; Malaquias, José B.; Okuma, Daniela M.; Miraldo, Leonardo L.; Amaral, Fernando S. de A. e; Omoto, Celso

    2016-01-01

    The resistance of fall armyworm (FAW), Spodoptera frugiperda, has been characterized to some Cry and Vip3A proteins of Bacillus thuringiensis (Bt) expressed in transgenic maize in Brazil. Here we evaluated the effective dominance of resistance based on the survival of neonates from selected Bt-resistant, heterozygous, and susceptible (Sus) strains of FAW on different Bt maize and cotton varieties. High survival of strains resistant to the Cry1F (HX-R), Cry1A.105/Cry2Ab (VT-R) and Cry1A.105/Cry2Ab/Cry1F (PW-R) proteins was detected on Herculex, YieldGard VT PRO and PowerCore maize. Our Vip3A-resistant strain (Vip-R) exhibited high survival on Herculex, Agrisure Viptera and Agrisure Viptera 3 maize. However, the heterozygous from HX-R × Sus, VT-R × Sus, PW-R × Sus and Vip-R × Sus had complete mortality on YieldGard VT PRO, PowerCore, Agrisure Viptera, and Agrisure Viptera 3, whereas the HX-R × Sus and Vip-R × Sus strains survived on Herculex maize. On Bt cotton, the HX-R, VT-R and PW-R strains exhibited high survival on Bollgard II. All resistant strains survived on WideStrike, but only PW-R and Vip-R × Sus survived on TwinLink. Our study provides useful data to aid in the understanding of the effectiveness of the refuge strategy for Insect Resistance Management of Bt plants. PMID:27721425

  10. Evaluation of the relationship of corneal biomechanical metrics with physical intraocular pressure and central corneal thickness in ex vivo rabbit eye globes.

    PubMed

    Bao, FangJun; Deng, ManLi; Wang, QinMei; Huang, JinHai; Yang, Jing; Whitford, Charles; Geraghty, Brendan; Yu, Ayong; Elsheikh, Ahmed

    2015-08-01

    The relationship of corneal biomechanical metrics provided by the Ocular Response Analyzer (ORA) and Corvis ST (CVS) with physical intraocular pressure (IOPp) and central corneal thickness (CCT) was evaluated. Thirty fresh enucleated eyes of 30 rabbits were used in ex vivo whole globe inflation experiments. IOPp was measured with a pressure transducer and increased from 7.5 to 37.5 mmHg in steps of 7.5 mmHg while biomechanical data was acquired using the ORA and CVS. At least 3 examinations were performed at each pressure level, where CCT and twelve biomechanical metrics were recorded and analyzed as a function of IOPp. The biomechanical metrics included corneal hysteresis (CH) and corneal resistance factor (CRF), obtained by the ORA. They also included the applanation times (A1T, A2T), lengths (A1L, A2L) and velocities (A1V, A2V), in addition to the highest concavity time (HCT), peak distance (PD), radius (HR) and deformation amplitude (DA), obtained by the CVS. The variation of CCT and the twelve biomechanical metrics for the 30 rabbit eyes tested across the 5 pressure stages considered (inter-pressure differences) were statistically significant (P = 0.00). IOPp was highly to moderately correlated with most biomechanical metrics, especially CRF, A1T, A1V, A2V, PD and DA, while the relationships with CH, A2T, A1L and HCT were poor. IOP has important influences on most corneal biomechanical metrics provided by CVS and ORA. Two biomechanical metrics A1V and HR were influenced by CCT after correcting for the effect of IOP in most pressure stages, while the correlation with others were weak. Comparisons of research groups based on ORA and CVS with different IOPs and CCTs may lead to possible misinterpretations if both or one of which are not considered in the analysis.

  11. Effect of aerosol propellants and surfactants on airway resistance

    PubMed Central

    Sterling, G. M.; Batten, J. C.

    1969-01-01

    The effects on the airways of inhalation of the vehicles used in two commercial pressurized bronchodilator aerosols were studied in 20 normal and seven asthmatic subjects. Changes in bronchial calibre due to bronchoconstriction were measured as changes in airway resistance using a constant volume whole body plethysmograph, and results were expressed as changes in the ratio Airway conductance/Thoracic gas volume (=specific airway conductance). The aerosols caused very slight bronchoconstriction in the normal subjects, with a mean decrease of 5·3% in specific airway conductance after inhalation of a spray containing sorbitol trioleate as a surface tension lowering agent, and of 9·7% after inhalation of a spray containing lecithin. This effect was prevented by prior inhalation of atropine methonitrate, and its mechanism was therefore probably a vagally mediated reflex. The bronchoconstriction was also reversed by the addition of isoprenaline to the aerosol. The asthmatic subjects showed larger mean reductions in specific airway conductance of 13% and 21% after sorbitol and lecithin respectively: the response was again prevented by atropine. We conclude that, although the aerosol vehicles cause slight bronchoconstriction, this is unlikely to be a clinical danger since it is insufficient to cause symptoms of wheezing, and is less than that caused by inhalation of a single cigarette. Moreover, the constriction is regularly converted to dilatation in both normal and asthmatic subjects by the addition of atropine or isoprenaline to the aerosol. PMID:5821624

  12. EFFECTS OF RESISTIVITY ON MAGNETIZED CORE-COLLAPSE SUPERNOVAE

    SciTech Connect

    Sawai, H.; Suzuki, H.; Yamada, S.; Kotake, K.

    2013-02-10

    We studied the role of turbulent resistivity in the core-collapse of a strongly magnetized massive star, carrying out two-dimensional resistive-MHD simulations. Three cases with different initial strengths of magnetic field and rotation are investigated: (1) a strongly magnetized rotating core, (2) a moderately magnetized rotating core, and (3) a very strongly magnetized non-rotating core. In each case, one ideal-MHD model and two resistive-MHD models are computed. As a result of these computations, each model shows an eruption of matter assisted by magnetic acceleration (and also by centrifugal acceleration in the rotating cases). We found that resistivity attenuates the explosion in cases 1 and 2, while it enhances the explosion in case 3. We also found that in the rotating cases, the main mechanisms for the amplification of a magnetic field in the post-bounce phase are an outward advection of the magnetic field and a twisting of poloidal magnetic field lines by differential rotation, which are somewhat dampened down with the presence of resistivity. Although magnetorotational instability seems to occur in the rotating models, it plays only a minor role in magnetic field amplification. Another impact of resistivity is that on the aspect ratio. In the rotating cases, a large aspect ratio of the ejected matter, >2.5, attained in an ideal-MHD model is reduced to some extent in a resistive model. These results indicate that resistivity possibly plays an important role in the dynamics of strongly magnetized supernovae.

  13. Soil spatial heterogeneity effect on soil electrical resistivity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Electrical resistivity (ER) is growing in popularity due to its ease of use and because of its non-invasive techniques, which are used to reveal and map soil heterogeneity. The objective of this work was to evaluate how differing soil properties affect the electric resistivity and to observe these e...

  14. Transverse Effect due to Short-range Resistive Wall Wakefield

    SciTech Connect

    Juhao Wu; Alex Chao; Jean Delayen

    2007-06-18

    For accelerator designs with ultra short electron beams, beam dynamics study has to invoke the short-range wakefields. In this paper, we first obtain the short-range dipole mode resistive wall wakefield. Analytical approach is then developed to study the single bunch transverse beam dynamics due to this short-range resistive wall wake. The results are applied to the LCLS undulator.

  15. Transverse Effect Due to Short Range Resistive Wall Wakefield

    SciTech Connect

    Delayen, J.R.; Chao, Alexander Wu; Wu, J.; /SLAC

    2008-01-08

    For accelerator designs with ultra short electron beams, beam dynamics study has to invoke the short-range wakefields. In this paper, we first obtain the short-range dipole mode resistive wall wakefield. Analytical approach is then developed to study the single bunch transverse beam dynamics due to this short-range resistive wall wake. The results are applied to the LCLS undulator.

  16. Effects of temperature and antibiotics on persistence of antibiotic-resistant bacteria and antibiotic resistance genes in poultry litter

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The effect of low, residual concentrations of antibiotics in manure and other environmental matrices is not well understood. It has been hypothesized that antibiotic concentrations below clinical MIC (minimal inhibitory concentrations) are still capable of selecting for resistance. The objective of ...

  17. A new distribution metric for image segmentation

    NASA Astrophysics Data System (ADS)

    Sandhu, Romeil; Georgiou, Tryphon; Tannenbaum, Allen

    2008-03-01

    In this paper, we present a new distribution metric for image segmentation that arises as a result in prediction theory. Forming a natural geodesic, our metric quantifies "distance" for two density functionals as the standard deviation of the difference between logarithms of those distributions. Using level set methods, we incorporate an energy model based on the metric into the Geometric Active Contour framework. Moreover, we briefly provide a theoretical comparison between the popular Fisher Information metric, from which the Bhattacharyya distance originates, with the newly proposed similarity metric. In doing so, we demonstrate that segmentation results are directly impacted by the type of metric used. Specifically, we qualitatively compare the Bhattacharyya distance and our algorithm on the Kaposi Sarcoma, a pathology that infects the skin. We also demonstrate the algorithm on several challenging medical images, which further ensure the viability of the metric in the context of image segmentation.

  18. Texture metric that predicts target detection performance

    NASA Astrophysics Data System (ADS)

    Culpepper, Joanne B.

    2015-12-01

    Two texture metrics based on gray level co-occurrence error (GLCE) are used to predict probability of detection and mean search time. The two texture metrics are local clutter metrics and are based on the statistics of GLCE probability distributions. The degree of correlation between various clutter metrics and the target detection performance of the nine military vehicles in complex natural scenes found in the Search_2 dataset are presented. Comparison is also made between four other common clutter metrics found in the literature: root sum of squares, Doyle, statistical variance, and target structure similarity. The experimental results show that the GLCE energy metric is a better predictor of target detection performance when searching for targets in natural scenes than the other clutter metrics studied.

  19. Human Performance Optimization Metrics: Consensus Findings, Gaps, and Recommendations for Future Research.

    PubMed

    Nindl, Bradley C; Jaffin, Dianna P; Dretsch, Michael N; Cheuvront, Samuel N; Wesensten, Nancy J; Kent, Michael L; Grunberg, Neil E; Pierce, Joseph R; Barry, Erin S; Scott, Jonathan M; Young, Andrew J; OʼConnor, Francis G; Deuster, Patricia A

    2015-11-01

    Human performance optimization (HPO) is defined as "the process of applying knowledge, skills and emerging technologies to improve and preserve the capabilities of military members, and organizations to execute essential tasks." The lack of consensus for operationally relevant and standardized metrics that meet joint military requirements has been identified as the single most important gap for research and application of HPO. In 2013, the Consortium for Health and Military Performance hosted a meeting to develop a toolkit of standardized HPO metrics for use in military and civilian research, and potentially for field applications by commanders, units, and organizations. Performance was considered from a holistic perspective as being influenced by various behaviors and barriers. To accomplish the goal of developing a standardized toolkit, key metrics were identified and evaluated across a spectrum of domains that contribute to HPO: physical performance, nutritional status, psychological status, cognitive performance, environmental challenges, sleep, and pain. These domains were chosen based on relevant data with regard to performance enhancers and degraders. The specific objectives at this meeting were to (a) identify and evaluate current metrics for assessing human performance within selected domains; (b) prioritize metrics within each domain to establish a human performance assessment toolkit; and (c) identify scientific gaps and the needed research to more effectively assess human performance across domains. This article provides of a summary of 150 total HPO metrics across multiple domains that can be used as a starting point-the beginning of an HPO toolkit: physical fitness (29 metrics), nutrition (24 metrics), psychological status (36 metrics), cognitive performance (35 metrics), environment (12 metrics), sleep (9 metrics), and pain (5 metrics). These metrics can be particularly valuable as the military emphasizes a renewed interest in Human Dimension efforts

  20. Effects of Oxidation on Oxidation-Resistant Graphite

    SciTech Connect

    Windes, William; Smith, Rebecca; Carroll, Mark

    2015-05-01

    The Advanced Reactor Technology (ART) Graphite Research and Development Program is investigating doped nuclear graphite grades that exhibit oxidation resistance through the formation of protective oxides on the surface of the graphite material. In the unlikely event of an oxygen ingress accident, graphite components within the VHTR core region are anticipated to oxidize so long as the oxygen continues to enter the hot core region and the core temperatures remain above 400°C. For the most serious air-ingress accident which persists over several hours or days the continued oxidation can result in significant structural damage to the core. Reducing the oxidation rate of the graphite core material during any air-ingress accident would mitigate the structural effects and keep the core intact. Previous air oxidation testing of nuclear-grade graphite doped with varying levels of boron-carbide (B4C) at a nominal 739°C was conducted for a limited number of doped specimens demonstrating a dramatic reduction in oxidation rate for the boronated graphite grade. This report summarizes the conclusions from this small scoping study by determining the effects of oxidation on the mechanical strength resulting from oxidation of boronated and unboronated graphite to a 10% mass loss level. While the B4C additive did reduce mechanical strength loss during oxidation, adding B4C dopants to a level of 3.5% or more reduced the as-fabricated compressive strength nearly 50%. This effectively minimized any benefits realized from the protective film formed on the boronated grades. Future work to infuse different graphite grades with silicon- and boron-doped material as a post-machining conditioning step for nuclear components is discussed as a potential solution for these challenges in this report.

  1. Hypoglycemic effects and mechanisms of electroacupuncture on insulin resistance.

    PubMed

    Yin, Jieyun; Kuang, Jian; Chandalia, Manisha; Tuvdendorj, Demidmaa; Tumurbaatar, Batbayar; Abate, Nicola; Chen, Jiande D Z

    2014-08-01

    The aim of this study was to investigate effects and mechanisms of electroacupuncture (EA) on blood glucose and insulin sensitivity in mice fed a high-fat diet. Both wild-type (WT) and adipose ectonucleotide pyrophosphate phosphodiesterase (ENPP1) transgenic (TG) mice were fed a high-fat diet for 12 wk; for each mouse, an intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT) were performed with or without EA at abdomen or auricular areas. A high-fat diet-induced insulin resistance in both WT and TG mice. In the WT mice, EA at 3 Hz and 15 Hz, but not at 1 Hz or 100 Hz, via CV4+CV12 significantly reduced postprandial glucose levels; EA at 3 Hz was most potent. The glucose level was reduced by 61.7% at 60 min and 74.5% at 120 min with EA at 3 Hz (all P < 0.001 vs. control). Similar hypoglycemic effect was noted in the TG mice. On the contrary, EA at auricular points increased postprandial glucose level (P < 0.03). 4). EA at 3 Hz via CV4+CV12 significantly enhanced the decrease of blood glucose after insulin injection, suggesting improvement of insulin sensitivity. Plasma free fatty acid was significantly suppressed by 42.5% at 15 min and 50.8% at 30 min with EA (P < 0.01) in both WT and TG mice. EA improves glucose tolerance in both WT and TG mice fed a high-fat diet, and the effect is associated with stimulation parameters and acupoints and is probably attributed to the reduction of free fatty acid.

  2. Fanpage metrics analysis. "Study on content engagement"

    NASA Astrophysics Data System (ADS)

    Rahman, Zoha; Suberamanian, Kumaran; Zanuddin, Hasmah Binti; Moghavvemi, Sedigheh; Nasir, Mohd Hairul Nizam Bin Md

    2016-08-01

    Social Media is now determined as an excellent communicative tool to connect directly with consumers. One of the most significant ways to connect with the consumers through these Social Networking Sites (SNS) is to create a facebook fanpage with brand contents and to place different posts periodically on these fanpages. In measuring social networking sites' effectiveness, corporate houses are now analyzing metrics in terms of calculating engagement rate, number of comments/share and likings in fanpages. So now, it is very important for the marketers to know the effectiveness of different contents or posts of fanpages in order to increase the fan responsiveness and engagement rate in the fan pages. In the study the authors have analyzed total 1834 brand posts from 17 international brands of Electronics companies. Data of 9 months (From December 2014 to August 2015) have been collected for analyses, which were available online in the Brand' fan pages. An econometrics analysis is conducted using Eviews 9, to determine the impact of different contents on fanpage engagement. The study picked the four most frequently posted content to determine their impact on PTA (people Talking About) metrics and Fanpage engagement activities.

  3. Predicting date rape perceptions: the effects of gender, gender role attitudes, and victim resistance.

    PubMed

    Black, Katherine A; McCloskey, Kathy A

    2013-08-01

    The effects of participant gender and victim resistance on date rape perceptions have been inconsistent. Participant gender role attitudes may contribute to these inconsistencies. We found women with traditional gender role attitudes were least likely to agree that the perpetrator was guilty of rape. Participants were less convinced of the perpetrator's guilt when the victim resisted verbally than when she resisted verbally and physically, and participants with traditional gender role attitudes were less convinced of the negative impact on the victim when she resisted verbally than when she resisted verbally and physically. Perhaps previous inconsistencies resulted from varying proportions of men and women with traditional versus liberal gender role attitudes in the samples.

  4. Deep Nonlinear Metric Learning for 3-D Shape Retrieval.

    PubMed

    Xie, Jin; Dai, Guoxian; Zhu, Fan; Shao, Ling; Fang, Yi

    2016-12-28

    Effective 3-D shape retrieval is an important problem in 3-D shape analysis. Recently, feature learning-based shape retrieval methods have been widely studied, where the distance metrics between 3-D shape descriptors are usually hand-crafted. In this paper, motivated by the fact that deep neural network has the good ability to model nonlinearity, we propose to learn an effective nonlinear distance metric between 3-D shape descriptors for retrieval. First, the locality-constrained linear coding method is employed to encode each vertex on the shape and the encoding coefficient histogram is formed as the global 3-D shape descriptor to represent the shape. Then, a novel deep metric network is proposed to learn a nonlinear transformation to map the 3-D shape descriptors to a nonlinear feature space. The proposed deep metric network minimizes a discriminative loss function that can enforce the similarity between a pair of samples from the same class to be small and the similarity between a pair of samples from different classes to be large. Finally, the distance between the outputs of the metric network is used as the similarity for shape retrieval. The proposed method is evaluated on the McGill, SHREC'10 ShapeGoogle, and SHREC'14 Human shape datasets. Experimental results on the three datasets validate the effectiveness of the proposed method.

  5. Metric Ranking of Invariant Networks with Belief Propagation

    SciTech Connect

    Tao, Changxia; Ge, Yong; Song, Qinbao; Ge, Yuan; Omitaomu, Olufemi A

    2014-01-01

    The management of large-scale distributed information systems relies on the effective use and modeling of monitoring data collected at various points in the distributed information systems. A promising approach is to discover invariant relationships among the monitoring data and generate invariant networks, where a node is a monitoring data source (metric) and a link indicates an invariant relationship between two monitoring data. Such an invariant network representation can help system experts to localize and diagnose the system faults by examining those broken invariant relationships and their related metrics, because system faults usually propagate among the monitoring data and eventually lead to some broken invariant relationships. However, at one time, there are usually a lot of broken links (invariant relationships) within an invariant network. Without proper guidance, it is difficult for system experts to manually inspect this large number of broken links. Thus, a critical challenge is how to effectively and efficiently rank metrics (nodes) of invariant networks according to the anomaly levels of metrics. The ranked list of metrics will provide system experts with useful guidance for them to localize and diagnose the system faults. To this end, we propose to model the nodes and the broken links as a Markov Random Field (MRF), and develop an iteration algorithm to infer the anomaly of each node based on belief propagation (BP). Finally, we validate the proposed algorithm on both realworld and synthetic data sets to illustrate its effectiveness.

  6. Product Operations Status Summary Metrics

    NASA Technical Reports Server (NTRS)

    Takagi, Atsuya; Toole, Nicholas

    2010-01-01

    The Product Operations Status Summary Metrics (POSSUM) computer program provides a readable view into the state of the Phoenix Operations Product Generation Subsystem (OPGS) data pipeline. POSSUM provides a user interface that can search the data store, collect product metadata, and display the results in an easily-readable layout. It was designed with flexibility in mind for support in future missions. Flexibility over various data store hierarchies is provided through the disk-searching facilities of Marsviewer. This is a proven program that has been in operational use since the first day of the Phoenix mission.

  7. Comparing Resource Adequacy Metrics: Preprint

    SciTech Connect

    Ibanez, E.; Milligan, M.

    2014-09-01

    As the penetration of variable generation (wind and solar) increases around the world, there is an accompanying growing interest and importance in accurately assessing the contribution that these resources can make toward planning reserve. This contribution, also known as the capacity credit or capacity value of the resource, is best quantified by using a probabilistic measure of overall resource adequacy. In recognizing the variable nature of these renewable resources, there has been interest in exploring the use of reliability metrics other than loss of load expectation. In this paper, we undertake some comparisons using data from the Western Electricity Coordinating Council in the western United States.

  8. Effects of antibiotic resistance alleles on bacterial evolutionary responses to viral parasites.

    PubMed

    Arias-Sánchez, Flor I; Hall, Alex R

    2016-05-01

    Antibiotic resistance has wide-ranging effects on bacterial phenotypes and evolution. However, the influence of antibiotic resistance on bacterial responses to parasitic viruses remains unclear, despite the ubiquity of such viruses in nature and current interest in therapeutic applications. We experimentally investigated this by exposing various Escherichia coli genotypes, including eight antibiotic-resistant genotypes and a mutator, to different viruses (lytic bacteriophages). Across 960 populations, we measured changes in population density and sensitivity to viruses, and tested whether variation among bacterial genotypes was explained by their relative growth in the absence of parasites, or mutation rate towards phage resistance measured by fluctuation tests for each phage. We found that antibiotic resistance had relatively weak effects on adaptation to phages, although some antibiotic-resistance alleles impeded the evolution of resistance to phages via growth costs. By contrast, a mutator allele, often found in antibiotic-resistant lineages in pathogenic populations, had a relatively large positive effect on phage-resistance evolution and population density under parasitism. This suggests costs of antibiotic resistance may modify the outcome of phage therapy against pathogenic populations previously exposed to antibiotics, but the effects of any co-occurring mutator alleles are likely to be stronger.

  9. Resistive Switching and Memory effects in Silicon Oxide Based Nanostructures

    NASA Astrophysics Data System (ADS)

    Yao, Jun

    Silicon oxide (SiOx 1 < x ≦2) has long been used and considered as a passive and insulating component in the construction of electronic devices. In contrast, here the active role of SiOx in constructing a type of resistive switching memory is studied. From electrode-independent electrical behaviors to the visualization of the conducting filament inside the SiOx matrix, the intrinsic switching picture in SiOx is gradually revealed. The thesis starts with the introduction of some similar phenomenological switching behaviors in different electronic structures (Chapter 1), and then generalizes the electrode-material-independent electrical behaviors on SiOx substrates, providing indirect evidence to the intrinsic SiOx switching (Chapter 2). From planar nanogap systems to vertical sandwiched structures, Chapter 3 further discusses the switching behaviors and properties in SiOx. By localization of the switching site, the conducting filament in SiOx is visualized under transmission electron microscope using both static and in situ imaging methods (Chapter 4). With the intrinsic conduction and switching in SiO x largely revealed, Chapter 5 discusses its impact and implications to the molecular electronics and nanoelectronics where SiOx is constantly used. As comparison, another type of memory effect in semiconductors (carbon nanotubes) based on charge trapping at the semiconductor/SiO x interface is discussed (Chapter 6).

  10. Effects of bacteriocins on methicillin-resistant Staphylococcus aureus biofilm.

    PubMed

    Okuda, Ken-ichi; Zendo, Takeshi; Sugimoto, Shinya; Iwase, Tadayuki; Tajima, Akiko; Yamada, Satomi; Sonomoto, Kenji; Mizunoe, Yoshimitsu

    2013-11-01

    Control of biofilms formed by microbial pathogens is an important subject for medical researchers, since the development of biofilms on foreign-body surfaces often causes biofilm-associated infections in patients with indwelling medical devices. The present study examined the effects of different kinds of bacteriocins, which are ribosomally synthesized antimicrobial peptides produced by certain bacteria, on biofilms formed by a clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA). The activities and modes of action of three bacteriocins with different structures (nisin A, lacticin Q, and nukacin ISK-1) were evaluated. Vancomycin, a glycopeptide antibiotic used in the treatment of MRSA infections, showed bactericidal activity against planktonic cells but not against biofilm cells. Among the tested bacteriocins, nisin A showed the highest bactericidal activity against both planktonic cells and biofilm cells. Lacticin Q also showed bactericidal activity against both planktonic cells and biofilm cells, but its activity against biofilm cells was significantly lower than that of nisin A. Nukacin ISK-1 showed bacteriostatic activity against planktonic cells and did not show bactericidal activity against biofilm cells. Mode-of-action studies indicated that pore formation leading to ATP efflux is important for the bactericidal activity against biofilm cells. Our results suggest that bacteriocins that form stable pores on biofilm cells are highly potent for the treatment of MRSA biofilm infections.

  11. Effectiveness of Genes for Hessian Fly (Diptera: Cecidomyiidae) Resistance in the Southeastern United States.

    PubMed

    Shukle, Richard H; Cambron, Sue E; Moniem, Hossam Abdel; Schemerhorn, Brandon J; Redding, Julie; David Buntin, G; Flanders, Kathy L; Reisig, Dominic D; Mohammadi, Mohsen

    2016-02-01

    The Hessian fly, Mayetiola destructor (Say) (Diptera: Cecidomyiidae), is the most important insect pest of wheat (Triticum aestivum L. subsp. aestivum) in the southeastern United States, and the deployment of genetically resistant wheat is the most effective control. However, the use of resistant wheat results in the selection of pest genotypes that can overcome formerly resistant wheat. We have evaluated the effectiveness of 16 resistance genes for protection of wheat from Hessian fly infestation in the southeastern United States. Results documented that while 10 of the genes evaluated could provide protection of wheat, the most highly effective genes were H12, H18, H24, H25, H26, and H33. However, H12 and H18 have been reported to be only partially effective in field evaluations, and H24, H25, and H26 may be associated with undesirable effects on agronomic traits when introgressed into elite wheat lines. Thus, the most promising new gene for Hessian fly resistance appears to be H33. These results indicate that identified highly effective resistance in wheat to the Hessian fly is a limited resource and emphasize the need to identify novel sources of resistance. Also, we recommend that the deployment of resistance in gene pyramids and the development of novel strategies for engineered resistance be considered.

  12. Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria

    PubMed Central

    Wu, Xiaozhe; Li, Zhan; Li, Xiaolu; Tian, Yaomei; Fan, Yingzi; Yu, Chaoheng; Zhou, Bailing; Liu, Yi; Xiang, Rong; Yang, Li

    2017-01-01

    Antibiotic-resistant bacteria present a great threat to public health. In this study, the synergistic effects of antimicrobial peptides (AMPs) and antibiotics on several multidrug-resistant bacterial strains were studied, and their synergistic effects on azithromycin (AZT)-resistance genes were analyzed to determine the relationships between antimicrobial resistance and these synergistic effects. A checkerboard method was used to evaluate the synergistic effects of AMPs (DP7 and CLS001) and several antibiotics (gentamicin, vancomycin [VAN], AZT, and amoxicillin) on clinical bacterial strains (Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli). The AZT-resistance genes (ermA, ermB, ermC, mefA, and msrA) were identified in the resistant strains using quantitative polymerase chain reaction. For all the clinical isolates tested that were resistant to different antibiotics, DP7 had high antimicrobial activity (≤32 mg/L). When DP7 was combined with VAN or AZT, the effect was most frequently synergistic. When we studied the resistance genes of the AZT-resistant isolates, the synergistic effect of DP7–AZT occurred most frequently in highly resistant strains or strains carrying more than two AZT-resistance genes. A transmission electron microscopic analysis of the S. aureus strain synergistically affected by DP7–AZT showed no noteworthy morphological changes, suggesting that a molecular-level mechanism plays an important role in the synergistic action of DP7–AZT. AMP DP7 plus the antibiotic AZT or VAN is more effective, especially against highly antibiotic-resistant strains. PMID:28356719

  13. Circumferential or sectored beam arrangements for stereotactic body radiation therapy (SBRT) of primary lung tumors: Effect on target and normal-structure dose-volume metrics

    SciTech Connect

    Rosenberg, Mara W.; Kato, Catherine M.; Carson, Kelly M.P.; Matsunaga, Nathan M.; Arao, Robert F.; Doss, Emily J.; McCracken, Charles L.; Meng, Lu Z.; Chen, Yiyi; Laub, Wolfram U.; Fuss, Martin; Tanyi, James A.

    2013-01-01

    To compare 2 beam arrangements, sectored (beam entry over ipsilateral hemithorax) vs circumferential (beam entry over both ipsilateral and contralateral lungs), for static-gantry intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques with respect to target and organs-at-risk (OAR) dose-volume metrics, as well as treatment delivery efficiency. Data from 60 consecutive patients treated using stereotactic body radiation therapy (SBRT) for primary non–small-cell lung cancer (NSCLC) formed the basis of this study. Four treatment plans were generated per data set: IMRT/VMAT plans using sectored (-s) and circumferential (-c) configurations. The prescribed dose (PD) was 60 Gy in 5 fractions to 95% of the planning target volume (PTV) (maximum PTV dose ∼ 150% PD) for a 6-MV photon beam. Plan conformality, R{sub 50} (ratio of volume circumscribed by the 50% isodose line and the PTV), and D{sub 2} {sub cm} (D{sub max} at a distance ≥2 cm beyond the PTV) were evaluated. For lungs, mean doses (mean lung dose [MLD]) and percent V{sub 30}/V{sub 20}/V{sub 10}/V{sub 5} Gy were assessed. Spinal cord and esophagus D{sub max} and D{sub 5}/D{sub 50} were computed. Chest wall (CW) D{sub max} and absolute V{sub 30}/V{sub 20}/V{sub 10}/V{sub 5} {sub Gy} were reported. Sectored SBRT planning resulted in significant decrease in contralateral MLD and V{sub 10}/V{sub 5} {sub Gy}, as well as contralateral CW D{sub max} and V{sub 10}/V{sub 5} {sub Gy} (all p < 0.001). Nominal reductions of D{sub max} and D{sub 5}/D{sub 50} for the spinal cord with sectored planning did not reach statistical significance for static-gantry IMRT, although VMAT metrics did show a statistically significant decrease (all p < 0.001). The respective measures for esophageal doses were significantly lower with sectored planning (p < 0.001). Despite comparable dose conformality, irrespective of planning configuration, R{sub 50} significantly improved with IMRT

  14. Banana Resistant Starch and Its Effects on Constipation Model Mice

    PubMed Central

    Wang, Juan; Huang, Ji Hong; Cheng, Yan Feng

    2014-01-01

    Abstract Banana resistant starch (BRS) was extracted to investigate the structural properties of BRS, its effects on the gastrointestinal transit, and dejecta of normal and experimentally constipated mice. The mouse constipation model was induced by diphenoxylate administration. The BRS administered mice were divided into three groups and gavaged with 1.0, 2.0, or 4.0 g/kg body weight BRS per day. The small intestinal movement, time of the first black dejecta, dejecta granules, weight and their moisture content, body weight, and food intake of mice were studied. Results showed that the BRS particles were oval and spindly and some light cracks and pits were in the surface. The degree of crystallinity of BRS was 23.13%; the main diffraction peaks were at 2θ 15.14, 17.38, 20.08, and 22.51. The degree of polymerization of BRS was 81.16 and the number-average molecular weight was 13147.92 Da, as determined by the reducing terminal method. In animal experiments, BRS at the dose of 4.0 g/kg body weight per day was able to increase the gastrointestinal propulsive rate, and BRS at the doses of 2.0 and 4.0 g/kg body weight per day was found to shorten the start time of defecation by observing the first black dejecta exhaust. However, there were no influences of BRS on the dejecta moisture content, the dejecta granules and their weight, body weight, or daily food intake in mice. BRS was effective in accelerating the movement of the small intestine and in shortening the start time of defecation, but did not impact body weight and food intake. Therefore, BRS had the potential to be useful for improving intestinal motility during constipation. PMID:25046686

  15. Hypotensive effects of resistance exercises with blood flow restriction.

    PubMed

    Neto, Gabriel R; Sousa, Maria S C; Costa, Pablo B; Salles, Belmiro F; Novaes, Giovanni S; Novaes, Jefferson S

    2015-04-01

    The effects of low-intensity resistance exercise (RE) combined with blood flow restriction (BFR) on blood pressure (BP) are an important factor to be considered because of the acute responses imposed by training. The aim of this study was to compare the hypotensive effect of RE performed with and without BFR in normotensive young subjects. After 1 repetition maximum (1RM) tests, 24 men (21.79 ± 3.21 years; 1.72 ± 0.06 m; 69.49 ± 9.80 kg) performed the following 4 experimental protocols in a randomized order: (a) high-intensity RE at 80% of 1RM (HI), (b) low-intensity RE at 20% of 1RM (LI), (c) low-intensity RE at 20% of 1RM combined with partial BFR (LI + BFR), and (d) control. Analysis of systolic blood pressure (SBP) and diastolic blood pressure (DBP) was conducted over a 60-minute period. The 3 RE protocols resulted in hypotensive SBP (HI = -3.8%, LI = -3.3%, LI + BFR = -5.5%) responses during the 60 minutes (p ≤ 0.05). The LI + BFR protocol promoted hypotensive (-11.5%) responses in DBP during the 60 minutes (p ≤ 0.05), and both the HI and LI + BFR protocols resulted in mean blood pressure (MBP) hypotension between 30 (-7.0%, -7.7%) and 60 minutes (-3.6%, -8.8%), respectively. In conclusion, postexercise hypotension may occur after all 3 exercise protocols with greater reductions in SBP after HI and LI + BFR, in DBP after LI + BFR, and in MBP after HI and LI + BFR protocols.

  16. Banana resistant starch and its effects on constipation model mice.

    PubMed

    Wang, Juan; Huang, Ji Hong; Cheng, Yan Feng; Yang, Gong Ming

    2014-08-01

    Banana resistant starch (BRS) was extracted to investigate the structural properties of BRS, its effects on the gastrointestinal transit, and dejecta of normal and experimentally constipated mice. The mouse constipation model was induced by diphenoxylate administration. The BRS administered mice were divided into three groups and gavaged with 1.0, 2.0, or 4.0 g/kg body weight BRS per day. The small intestinal movement, time of the first black dejecta, dejecta granules, weight and their moisture content, body weight, and food intake of mice were studied. Results showed that the BRS particles were oval and spindly and some light cracks and pits were in the surface. The degree of crystallinity of BRS was 23.13%; the main diffraction peaks were at 2(θ) 15.14, 17.38, 20.08, and 22.51. The degree of polymerization of BRS was 81.16 and the number-average molecular weight was 13147.92 Da, as determined by the reducing terminal method. In animal experiments, BRS at the dose of 4.0 g/kg body weight per day was able to increase the gastrointestinal propulsive rate, and BRS at the doses of 2.0 and 4.0 g/kg body weight per day was found to shorten the start time of defecation by observing the first black dejecta exhaust. However, there were no influences of BRS on the dejecta moisture content, the dejecta granules and their weight, body weight, or daily food intake in mice. BRS was effective in accelerating the movement of the small intestine and in shortening the start time of defecation, but did not impact body weight and food intake. Therefore, BRS had the potential to be useful for improving intestinal motility during constipation.

  17. The effects of immunity and resistance on the development of AIDS

    NASA Astrophysics Data System (ADS)

    Abell, Martha; Braselton, James; Braselton, Lorraine

    2007-09-01

    We incorporate basic genetics into an AIDS model. We illustrate that if a homozygote is immune to the disease or is resistant to the effects of the disease, the corresponding allele goes to fixation. On the other hand, if the heterozygote is immune to the disease or is resistant to the effects of the disease, polymorphism usually occurs.

  18. A family of heavenly metrics

    NASA Astrophysics Data System (ADS)

    Nutku, Y.; Sheftel, M. B.

    2014-02-01

    This is a corrected and essentially extended version of the unpublished manuscript by Y Nutku and M Sheftel which contains new results. It is proposed to be published in honour of Y Nutku’s memory. All corrections and new results in sections 1, 2 and 4 are due to M Sheftel. We present new anti-self-dual exact solutions of the Einstein field equations with Euclidean and neutral (ultra-hyperbolic) signatures that admit only one rotational Killing vector. Such solutions of the Einstein field equations are determined by non-invariant solutions of Boyer-Finley (BF) equation. For the case of Euclidean signature such a solution of the BF equation was first constructed by Calderbank and Tod. Two years later, Martina, Sheftel and Winternitz applied the method of group foliation to the BF equation and reproduced the Calderbank-Tod solution together with new solutions for the neutral signature. In the case of Euclidean signature we obtain new metrics which asymptotically locally look like a flat space and have a non-removable singular point at the origin. In the case of ultra-hyperbolic signature there exist three inequivalent forms of metric. Only one of these can be obtained by analytic continuation from the Calderbank-Tod solution whereas the other two are new.

  19. Elliptic constructions of hyperkahler metrics

    NASA Astrophysics Data System (ADS)

    Ionas, Radu Aurelian

    In this dissertation we develop a twistor-theoretic method of constructing hyperkahler metrics from holomorphic functions and elliptic curves. We obtain, among other things, new results concerning the Atiyah-Hitchin manifold, asymptotically locally Euclidean spaces of type Dn and certain Swann bundles. For example, in the Atiyah-Hitchin case we derive in an explicit holomorphic coordinate basis closed-form formulas for the metric, the holomorphic symplectic form and all three Kahler potentials. The equation describing an asymptotically locally Euclidean space of type Dn is found to admit an algebraic formulation in terms of the group law on a Weierstrass cubic. This curve has the structure of a Cayley cubic for a pencil generated by two transversal plane conics, that is, it takes the form Y2 = det( A+XB ), where A and B are the defining 3 x 3 matrices of the conics. In this light, the equation can be interpreted as the closure condition for an elliptic billiard trajectory tangent to the conic B and bouncing into various conics of the pencil determined by the positions of the monopoles.

  20. Determining GPS average performance metrics

    NASA Technical Reports Server (NTRS)

    Moore, G. V.

    1995-01-01

    Analytic and semi-analytic methods are used to show that users of the GPS constellation can expect performance variations based on their location. Specifically, performance is shown to be a function of both altitude and latitude. These results stem from the fact that the GPS constellation is itself non-uniform. For example, GPS satellites are over four times as likely to be directly over Tierra del Fuego than over Hawaii or Singapore. Inevitable performance variations due to user location occur for ground, sea, air and space GPS users. These performance variations can be studied in an average relative sense. A semi-analytic tool which symmetrically allocates GPS satellite latitude belt dwell times among longitude points is used to compute average performance metrics. These metrics include average number of GPS vehicles visible, relative average accuracies in the radial, intrack and crosstrack (or radial, north/south, east/west) directions, and relative average PDOP or GDOP. The tool can be quickly changed to incorporate various user antenna obscuration models and various GPS constellation designs. Among other applications, tool results can be used in studies to: predict locations and geometries of best/worst case performance, design GPS constellations, determine optimal user antenna location and understand performance trends among various users.

  1. Metrics for building performance assurance

    SciTech Connect

    Koles, G.; Hitchcock, R.; Sherman, M.

    1996-07-01

    This report documents part of the work performed in phase I of a Laboratory Directors Research and Development (LDRD) funded project entitled Building Performance Assurances (BPA). The focus of the BPA effort is to transform the way buildings are built and operated in order to improve building performance by facilitating or providing tools, infrastructure, and information. The efforts described herein focus on the development of metrics with which to evaluate building performance and for which information and optimization tools need to be developed. The classes of building performance metrics reviewed are (1) Building Services (2) First Costs, (3) Operating Costs, (4) Maintenance Costs, and (5) Energy and Environmental Factors. The first category defines the direct benefits associated with buildings; the next three are different kinds of costs associated with providing those benefits; the last category includes concerns that are broader than direct costs and benefits to the building owner and building occupants. The level of detail of the various issues reflect the current state of knowledge in those scientific areas and the ability of the to determine that state of knowledge, rather than directly reflecting the importance of these issues; it intentionally does not specifically focus on energy issues. The report describes work in progress and is intended as a resource and can be used to indicate the areas needing more investigation. Other reports on BPA activities are also available.

  2. Mesoscale spatial variability of selected aquatic invertebrate community metrics from a minimally impaired stream segment

    USGS Publications Warehouse

    Gebler, J.B.

    2004-01-01

    The related topics of spatial variability of aquatic invertebrate community metrics, implications of spatial patterns of metric values to distributions of aquatic invertebrate communities, and ramifications of natural variability to the detection of human perturbations were investigated. Four metrics commonly used for stream assessment were computed for 9 stream reaches within a fairly homogeneous, minimally impaired stream segment of the San Pedro River, Arizona. Metric variability was assessed for differing sampling scenarios using simple permutation procedures. Spatial patterns of metric values suggest that aquatic invertebrate communities are patchily distributed on subsegment and segment scales, which causes metric variability. Wide ranges of metric values resulted in wide ranges of metric coefficients of variation (CVs) and minimum detectable differences (MDDs), and both CVs and MDDs often increased as sample size (number of reaches) increased, suggesting that any particular set of sampling reaches could yield misleading estimates of population parameters and effects that can be detected. Mean metric variabilities were substantial, with the result that only fairly large differences in metrics would be declared significant at ?? = 0.05 and ?? = 0.20. The number of reaches required to obtain MDDs of 10% and 20% varied with significance level and power, and differed for different metrics, but were generally large, ranging into tens and hundreds of reaches. Study results suggest that metric values from one or a small number of stream reach(es) may not be adequate to represent a stream segment, depending on effect sizes of interest, and that larger sample sizes are necessary to obtain reasonable estimates of metrics and sample statistics. For bioassessment to progress, spatial variability may need to be investigated in many systems and should be considered when designing studies and interpreting data.

  3. A high-throughput contact-hole resolution metric for photoresists:Full-process sensitivity study

    SciTech Connect

    Anderson, Christopher N.; Naulleau, Patrick P.

    2008-01-22

    The ability to accurately quantify the intrinsic resolution of chemically amplified photoresists is critical for the optimization of resists for extreme ultraviolet (EUV) Iithography. We have recently reported on two resolution metrics that have been shown to extract resolution numbers consistent with direct observation. In this paper we examine the previously reported contact-hole resolution metric and explore the sensitivity of the metric to potential error sources associated with the experimental side of the resolution extraction process. For EUV exposures at the SEMATECH Berkeley microfield exposure tool, we report a full-process error-bar in extracted resolution of 1.75 nm RMS and verify this result experimentally.

  4. An overview of climate change metrics, latest developments and links with air quality (Invited)

    NASA Astrophysics Data System (ADS)

    Forster, P.

    2013-12-01

    Greenhouse gas (GHG) metrics underpin most climate policies by allowing emissions of different GHGs and other forcing agents to be expressed in a common unit. They have potentially benefited climate policy by allowing substitution among different gases ( a so called 'basket approach'). The choice of metric and especially its time horizon depend on the policy context and there is no perfect metric as no single metric can capture all the nuances of the climate and/or air quality effects policy makers maybe interested in addressing. This is especially true when considering regional effects. We will discuss case studies for aviation emissions and black carbon emissions to test specific situations where pragmatic metric choice can guide sensible policy decisions. We give several examples of clear win-win situations for both air quality and climate, where decisions would be relatively insensitive to metric choice.

  5. The Equivalence of Precession Phenomena in Metric Theories of Gravity

    NASA Technical Reports Server (NTRS)

    Krisher, Timothy P.

    1996-01-01

    The requirement of general covariance imparts to metric theories of gravity, such as general relativity, important structural features. A precise mathematical form results, ensuring that computation of observable physical effects in the theory gives the same answers independently of the chosen system of coordinates. This coordinate independence property, in turn, can lead to an equivalence of apparently different physical effects.

  6. Mechanisms for Breast Cancer Cell Resistance to Doxorubicin and Solutions to Resistance and Side Effects

    DTIC Science & Technology

    2001-10-01

    alkylation and crosslinking of DNA as important toxic events triggering cell death. The long term goals of the proposed research are to establish the...mechanism for the crosslinking , to produce new mechanism-based anthracycline derivatives which will be active against resistant breast cancer, and to...of epidoxorubicin- alkylated DNA shows the epidoxorubicin virtually crosslinking the DNA at NGC sites. 2) Flow cytometry measurements show drug

  7. Light-Induced Resistance Effect Observed in Nano Au Films Covered Two-Dimensional Colloidal Crystals.

    PubMed

    Liu, Shuai; Huang, Meizhen; Yao, Yanjie; Wang, Hui; Jin, Kui-juan; Zhan, Peng; Wang, Zhenlin

    2015-09-09

    Tailoring resistance response using periodic nanostructures is one of the key issues in the current research. Two-dimensional colloidal crystals (CCs) structure is one of popular periodic nanospheres' structures and most of reports are focused on anomalous transmission of light or biomedical applications. In this work, a light-induced resistance effect is observed on silicon-based Au films covered CCs, featuring a remarkable resistance change as much as 56% and resistance switching characteristic. The diffusion and recombination of photocarriers is the crucial factor for this effect. This finding will expand photoelectricity functionality and be useful for future development of CC-based photoelectric devices.

  8. Jacobi-Maupertuis-Eisenhart metric and geodesic flows

    NASA Astrophysics Data System (ADS)

    Chanda, Sumanto; Gibbons, G. W.; Guha, Partha

    2017-03-01

    The Jacobi metric derived from the line element by one of the authors is shown to reduce to the standard formulation in the non-relativistic approximation. We obtain the Jacobi metric for various stationary metrics. Finally, the Jacobi-Maupertuis metric is formulated for time-dependent metrics by including the Eisenhart-Duval lift, known as the Jacobi-Eisenhart metric.

  9. 48 CFR 611.002-70 - Metric system implementation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... item is designated, produced and described in inch-pound values with soft metric values also shown for... of measurement sensitive processes and systems to the metric system. Soft metric means the result of... possible. Alternatives to hard metric are soft, dual and hybrid metric terms. The Metric Handbook...

  10. Personality Factors and Resistance to the Effects of Frustrations on Creative Problem-Solving Performance

    ERIC Educational Resources Information Center

    Hinton, Bernard L.

    1971-01-01

    Shows the relationship between certain personality variables and resistance to the effects of frustration on creativity, and shows the combined effects of personality and emotional stress on creative productivity. (Author)

  11. Environmental variation alters the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosa.

    PubMed

    Gifford, Danna R; Moss, Ethan; MacLean, R Craig

    2016-03-01

    The fitness effects of antibiotic resistance mutations in antibiotic-free conditions play a key role in determining the long-term maintenance of resistance. Although resistance is usually associated with a cost, the impact of environmental variation on the cost of resistance is poorly understood. Here, we test the impact of heterogeneity in temperature and resource availability on the fitness effects of antibiotic resistance using strains of the pathogenic bacterium Pseudomonas aeruginosa carrying clinically important rifampicin resistance mutations. Although the rank order of fitness was generally maintained across environments, fitness effects relative to the wild type differed significantly. Changes in temperature had a profound impact on the fitness effects of resistance, whereas changes in carbon substrate had only a weak impact. This suggests that environmental heterogeneity may influence whether the costs of resistance are likely to be ameliorated by second-site compensatory mutations or by reversion to wild-type rpoB. Our results highlight the need to consider environmental heterogeneity and genotype-by-environment interactions for fitness in models of resistance evolution.

  12. The effects of myxobolus cerebralis on the physiological performance of whirling disease resistant and susceptible strains of rainbow trout

    USGS Publications Warehouse

    Fetherman, E.R.; Myrick, Christopher A.; Winkelman, D.L.; Schisler, G.J.

    2011-01-01

    The development of rainbow trout Oncorhynchus mykiss strains that are resistant to whirling disease has shown promise as amanagement tool for populationsin areas where Myxobolus cerebralisis present. However, the physiological effects of the disease on characteristics necessary for fish survival in natural river conditions have not been tested in many of these strains. Five rainbow trout strains were evaluated for their swimming ability and growth characteristics in relation to M. cerebralis exposure: the resistant German rainbow trout (GR) strain (Hofer strain), the susceptible Colorado River rainbow trout (CRR) strain, and three intermediate (hybrid) strains (F1 = GR ?? CRR; F2 = F1 ?? F1; B2 = backcross of F1 ?? CRR). Three broad response patterns among strain and exposure were evident in our study. First, exposure metrics, growth performance, and swimming ability differed among strains. Second, exposure to the parasite did not necessarily produce differences in growth or swimming ability. Exposure to M. cerebralis did not affect batch weight for any strain, and critical swimming velocity did not differ between exposed and unexposed families. Third, although exposure did not necessarily affect growth or swimming ability, individuals that exhibited clinical deformities did show reduced growth and swimming performance; fish with clinical deformities were significantly smaller and had lower critical swimming velocities than exposed fish without clinical deformities. Research and management have focused on GR ?? CRR hybrid strains; however, given the performance of the GR strain in our study, it should not be discounted as a potential broodstock. Additional field trials comparing the GR and F1 strains should be conducted before wholesale adoption of the GR strain to reestablish rainbow trout populations in Colorado. ?? American Fisheries Society 2011.

  13. Effects of interadsorbate interactions on surface resistivity: oxygen on sulfur-predosed Cu(100).

    PubMed

    Liu, Chang; Tobin, R G

    2008-06-28

    Measurements of surface resistivity as a function of coverage for oxygen adsorbed on sulfur-predosed Cu(100) films reveal two types of interactions between sulfur and oxygen: S-O repulsion and short-range suppression of the surface resistivity change induced by oxygen adsorption. The repulsive interaction causes oxygen atoms to first occupy adsorption sites far from the sulfur atoms, beyond second-nearest-neighbor sites, where the oxygen-induced surface resistivity is unaffected by sulfur. As a result the low-coverage variation of surface resistivity with oxygen coverage is indistinguishable from the linear dependence observed for oxygen on clean Cu(100). As the oxygen coverage increases, oxygen begins to occupy sites close to sulfur. At the nearest-neighbor sites, the resistivity change due to added oxygen is completely suppressed, and the sample resistance levels off, remaining unchanged even as oxygen continues to adsorb. This resistivity suppression may involve both a reduction of oxygen's direct effect on the resistivity and an oxygen-induced reduction in the resistivity due to the already adsorbed sulfur. With increasing sulfur precoverage both the maximum resistivity change and the oxygen coverage at which the leveling occurs decrease, because the number of sites unaffected by sulfur is reduced. Both the sulfur-oxygen repulsion and the resistivity suppression presumably arise from a through-metal coupling involving adsorbate-induced modifications of the local electronic structure.

  14. Two-Basket Approach and Emission Metrics

    NASA Astrophysics Data System (ADS)

    Tanaka, K.; Schmale, J.; von Schneidemesser, E.

    2013-12-01

    Cutting the emissions of Short-Lived Climate-Forcing Air Pollutants (SLCPs) gains increasing global attention as a mitigation policy option because of direct benefits for climate and co-benefits such as improvements in air quality. Including SLCPs as target components to abate within a single basket (e.g. the Kyoto Protocol) would, however, face issues with regard to: i) additional assumptions that are required to compare SLCP emissions and CO2 emissions within a basket in terms of climatic effects, especially because of the difference in lifetimes, ii) the accountability of non-climatic effects in the emission trading between SLCPs and CO2. The idea of a two-basket approach was originally proposed as a climatic analogue to the Montreal Protocol dealing with ozone depleting substances (Jackson 2009; Daniel et al. 2012; Smith et al. 2013). In a two-basket approach, emissions are allowed to be traded within a basket but not across the baskets. While this approach potentially ensures scientifically supported emission trading (e.g. (Smith et al. 2013)), this approach leaves open the important issue of how to determine the relative weight between two baskets. Determining the weight cannot be answered by science alone, as the question involves a value judgment as stressed in metric studies (e.g. (Tanaka et al. 2010; Tanaka et al. 2013)). We discuss emission metrics in the context of a two-basket approach and present policy implications of such an approach. In a two-basket approach, the weight between two baskets needs to be determined a priori or exogenously. Here, an opportunity arises to present synergetic policy options targeted at mitigating climate change and air pollution simultaneously. In other words, this could be a strategy to encourage policymakers to consider cross-cutting issues. Under a two-basket climate policy, policymakers would be exposed to questions such as: - What type of damages caused by climate change does one choose to avoid? - To what extent

  15. Cyclic resistive switching effect in plasma electrolytically oxidized mesoporous Pt/TiO2 structures

    NASA Astrophysics Data System (ADS)

    Fullam, S.; Ray, N. J.; Karpov, E. G.

    2015-06-01

    Understanding the resistive switching phenomenon in metal oxide semiconductors is necessary in producing reliable resistive random access memory and other variable resistance devices. An alternative technique for fabricating resistive switching elements is presented. Using plasma electrolytic oxidation, 10-11 μ m thick oxide layers were galvanostatically grown on Ti substrates in a 3 M H2SO4 electrolyte. Analysis of the TiO2 layer by SEM, AFM, and XRD found the mesoporous titania surface to have a high ratio of rutile to anatase phases. The samples demonstrated pinched I-V hysteresis attributed to the resistive switching effect, when subjected to cyclic loading (±2.5, 1.6, 0.7 V; 23-736 μ Hz) at room temperature. Ratio with magnitude of 6 is reported for the resistance switching effect during 1.6 V 368 μ Hz loads.

  16. Rainbow metric from quantum gravity: Anisotropic cosmology

    NASA Astrophysics Data System (ADS)

    Assanioussi, Mehdi; Dapor, Andrea

    2017-03-01

    In this paper we present a construction of effective cosmological models which describe the propagation of a massive quantum scalar field on a quantum anisotropic cosmological spacetime. Each obtained effective model is represented by a rainbow metric in which particles of distinct momenta propagate on different classical geometries. Our analysis shows that upon certain assumptions and conditions on the parameters determining such anisotropic models, we surprisingly obtain a unique deformation parameter β in the modified dispersion relation of the modes, hence, inducing an isotropic deformation despite the general starting considerations. We then ensure the recovery of the dispersion relation realized in the isotropic case, studied in [M. Assanioussi, A. Dapor, and J. Lewandowski, Phys. Lett. B 751, 302 (2015), 10.1016/j.physletb.2015.10.043], when some proper symmetry constraints are imposed, and we estimate the value of the deformation parameter for this case in loop quantum cosmology context.

  17. Fractional coverage metrics based on ecological home range for calculation of the effective peak capacity in comprehensive two-dimensional separations.

    PubMed

    Rutan, Sarah C; Davis, Joe M; Carr, Peter W

    2012-09-14

    Optimization of comprehensive two-dimensional separations frequently relies on the assessment of the peak capacity of the system. A correction is required for the fact that many pairs of separation systems are to some degree correlated, and consequently the entire separation space is not chemically accessible to solutes. This correction is essentially a measure of the fraction of separation space area where the solutes may elute. No agreement exists in the literature as to the best form of the spatial coverage factor. In this work, we distinguish between spatial coverage factors that measure the maximum occupiable space, which is characteristic of the separation dimensionality, and the space actually occupied by a particular sample, which is characteristic of the sample dimensionality. It is argued that the former, which we call f(coverage), is important to calculating the peak capacity. We propose five criteria for a good f(coverage) metric and use them to evaluate various area determination methods that are used to measure animal home ranges in ecology. We consider minimum convex hulls, convex hull peels, α-hulls, three variations of local hull methods, and a kernel method and compare the results to the intuitively satisfying but subjective Stoll-Gilar method. The most promising methods are evaluated using two experimental LC×LC data sets, one with fixed separation chemistry but variable gradient times, and a second with variable first dimension column chemistry. For the 12 separations in the first data set, in which f(coverage) is expected to be constant, the minimum convex hull is the most precise method (f(coverage)=0.68±0.04) that gives similar results to the Stoll-Gilar method (f(coverage)=0.67±0.06). The minimum convex hull is proposed as the best method for calculating f(coverage), because it has no adjustable parameters, can be scaled to different retention time normalizations, is easily calculated using available software, and represents the expected

  18. Fighter agility metrics, research, and test

    NASA Technical Reports Server (NTRS)

    Liefer, Randall K.; Valasek, John; Eggold, David P.

    1990-01-01

    Proposed new metrics to assess fighter aircraft agility are collected and analyzed. A framework for classification of these new agility metrics is developed and applied. A completed set of transient agility metrics is evaluated with a high fidelity, nonlinear F-18 simulation provided by the NASA Dryden Flight Research Center. Test techniques and data reduction methods are proposed. A method of providing cuing information to the pilot during flight test is discussed. The sensitivity of longitudinal and lateral agility metrics to deviations from the pilot cues is studied in detail. The metrics are shown to be largely insensitive to reasonable deviations from the nominal test pilot commands. Instrumentation required to quantify agility via flight test is also considered. With one exception, each of the proposed new metrics may be measured with instrumentation currently available. Simulation documentation and user instructions are provided in an appendix.

  19. The effectiveness of resisted movement training on sprinting and jumping performance.

    PubMed

    Hrysomallis, Con

    2012-01-01

    Resisted movement training is that in which the sports movement is performed with added resistance. To date, the effectiveness on enhancing sprint speed or vertical jump height had not been reviewed. The objectives of this review were to collate information on resisted training studies for sprinting and vertical jumping, ascertain whether resisted movement training was superior to normal unresisted movement training, and identify areas for future research. The review was based on peer-reviewed journal articles identified from electronic literature searches using MEDLINE and SPORTDiscus data bases from 1970 to 2010. Resisted sprint training was found to increase sprint speed but, in most cases, was no more effective than normal sprint training. There was some evidence that resisted sprint training was superior in increasing speed in the initial acceleration phase of sprinting. Resisted jump training in the form of weighted jump squats was shown to increase vertical jump height, but it was no more effective than plyometric depth jump training. Direct comparisons between resisted jump training and unresisted normal jump training were limited, but loaded eccentric countermovement jump squat training with unloaded concentric phase and eccentric landing was shown to generate superior results for elite jumpers. More prospective studies on resisted sprint training are required along with monitoring both kinematic and kinetic adaptations to fully determine any underlying mechanisms for any improvements in sprint speed. Based on the available data, the benefits and superiority of resisted sprint training have not been fully established. As for resisted jump training, although there are some promising findings, these results need to be duplicated by other researchers before resisted jump training can be claimed to be more effective than other forms of jump training.

  20. Common Metrics for Human-Robot Interaction

    NASA Technical Reports Server (NTRS)

    Steinfeld, Aaron; Lewis, Michael; Fong, Terrence; Scholtz, Jean; Schultz, Alan; Kaber, David; Goodrich, Michael

    2006-01-01

    This paper describes an effort to identify common metrics for task-oriented human-robot interaction (HRI). We begin by discussing the need for a toolkit of HRI metrics. We then describe the framework of our work and identify important biasing factors that must be taken into consideration. Finally, we present suggested common metrics for standardization and a case study. Preparation of a larger, more detailed toolkit is in progress.

  1. Metrics for antibody therapeutics development.

    PubMed

    Reichert, Janice M

    2010-01-01

    A wide variety of full-size monoclonal antibodies (mAbs) and therapeutics derived from alternative antibody formats can be produced through genetic and biological engineering techniques. These molecules are now filling the preclinical and clinical pipelines of every major pharmaceutical company and many biotechnology firms. Metrics for the development of antibody therapeutics, including averages for the number of candidates entering clinical study and development phase lengths for mAbs approved in the United States, were derived from analysis of a dataset of over 600 therapeutic mAbs that entered clinical study sponsored, at least in part, by commercial firms. The results presented provide an overview of the field and context for the evaluation of on-going and prospective mAb development programs. The expansion of therapeutic antibody use through supplemental marketing approvals and the increase in the study of therapeutics derived from alternative antibody formats are discussed.

  2. Effects of ultraviolet light disinfection on tetracycline-resistant bacteria in wastewater effluents.

    PubMed

    Childress, H; Sullivan, B; Kaur, J; Karthikeyan, R

    2014-09-01

    The ubiquitous use of antibiotics has led to an increasing number of antibiotic-resistant bacterial strains, including strains that are multidrug-resistant, pathogenic, or both. There is also evidence to suggest that antibiotic resistance genes (ARGs) spread to the environment, humans, and animals through wastewater effluents. The overall objective of this study was to investigate the effect of ultraviolet (UV) light disinfection on antibiotic-resistant bacteria. Wastewater effluent samples from a wastewater treatment plant (WWTP) in Texas were evaluated for differences in tetracycline-resistant bacteria before and after UV treatment. The effects of photoreactivation or dark repair on the reactivation of bacteria present in WWTP effluent after UV disinfection were also examined. Culture-based methods were used to characterize viable heterotrophic, tetracycline-resistant heterotrophic, Escherichia coli, and tetracycline-resistant E. coli bacteria present before and after UV treatment. UV disinfection was found to be as effective at reducing concentrations of resistant heterotrophs and E. coli, as it was at reducing total bacterial concentrations. The lowest survival ratio following UV disinfection was observed in tetracycline-resistant E. coli showing particular susceptibility to UV treatment. Photoreactivation and dark repair rates were found to be comparable to each other for all bacterial populations.

  3. Effects of resistance training on force steadiness and common drive.

    PubMed

    Beck, Travis W; Defreitas, Jason M; Stock, Matt S; Dillon, Michael A

    2011-02-01

    The purpose of this study was to investigate the influence of an 8-week resistance training program on force steadiness and common drive for the vastus lateralis muscle. Eight untrained men performed a resistance training program. Before the program and at the end of each week, the subjects performed a trapezoid isometric muscle action of the leg extensors, and bipolar surface electromyographic signals were recorded from the vastus lateralis. The signals were decomposed into action potential trains that were cross-correlated to measure common drive. Force steadiness was quantified as the standard deviation of force during the constant-force portion of the trapezoid muscle action. The training program did not consistently affect force steadiness or common drive for any of the subjects. Although future studies are needed with different muscles and training programs, changes in the overall motor control scheme are not likely with resistance training.

  4. Nickel-cadmium Battery Cell Reversal from Resistive Network Effects

    NASA Technical Reports Server (NTRS)

    Zimmerman, A. H.

    1985-01-01

    During the individual cell short-down procedures often used for storing or reconditioning nickel-cadmium (Ni-Cd) batteries, it is possible for significant reversal of the lowest capacity cells to occur. The reversal is caused by the finite resistance of the common current-carrying leads in the resistive network that is generally used during short-down. A model is developed to evaluate the extent of such a reversal in any specific battery, and the model is verified by means of data from the short-down of a f-cell, 3.5-Ah battery. Computer simulations of short-down on a variety of battery configurations indicate the desirability of controlling capacity imbalances arising from cell configuration and battery management, limiting variability in the short-down resistors, minimizing lead resistances, and optimizing lead configurations.

  5. Effect of nonsymmetrical flow resistance upon orifice impedance

    NASA Technical Reports Server (NTRS)

    Posey, J. W.; Compton, K. J.

    1974-01-01

    Previous laboratory work has indicated that an orifice in a thin sheet behaves in a quasisteady manner under acoustical excitation. Also, it has been found that the steady flow resistance of an orifice may be dependent upon the direction of flow, especially in the presence of a crossflow on one side of the hole. An analytical study is presented which assumes a nonreactive orifice in an infinite baffle. The pressure difference across the orifice varies sinusoidally with amplitude 1.0 and average value -P. The orifice resistance is discontinuous at zero velocity and exhibits the constant values when the velocity is nonzero. The resultant velocity has power in all harmonics of the excitation frequency, providing an explanation of the even harmonic excitation observed by other investigators, but not predicted by symmetric nonlinearity. A quasilinear resistance is defined and found to be relatively insensitive to the presence or absence of a resonant backing cavity.

  6. Effects of Resistance to Bt Cotton on Diapause in the Pink Bollworm, Pectinophora gossypiella

    PubMed Central

    Carrière, Yves; Ellers-Kirk, Christa; Biggs, Robert W.; Sims, Maria A.; Dennehy, Timothy J.; Tabashnik, Bruce E.

    2007-01-01

    Fitness costs associated with resistance to Bacillus thuringiensis (Bt) crops are expected to delay the evolution of resistance. In a previous study where pink bollworm, Pectinophora gossypiella (Lepidoptera: Gelechiidae), larvae overwintered in outdoor insectaries, individuals from Bt-resistant strains had lower survival than individuals from Bt-susceptible strains or F1 progeny from crosses between resistant and susceptible adults. To investigate the physiological basis of such recessive cost, diapause duration was experimentally manipulated in the laboratory. Compared to a Bt-susceptible strain and F1 progeny, we hypothesized that Bt-resistant strains could exhibit a lower propensity or intensity of diapause, faster weight loss during overwintering, lower initial weight of diapausing larvae, and reduced longevity of moths emerging from diapause. Results were as expected for initial weight of diapausing larvae and longevity of overwintered male moths or female moths remaining in diapause for a short period. However, a higher diapause induction and intensity and slower weight loss occurred in F1 progeny and Bt-resistant strains than in a Bt-susceptible strain. Moreover, F1 progeny had greater overwintering survival than the Bt-resistant and Bt-susceptible strains, and F1 female moths had the greatest longevity after sustaining long diapausing periods. All of these unexpected results may be explained by pleiotropic effects of resistance to Bt cotton that increased the strength of diapause in the F1 progeny and Bt-resistant strains. Incomplete resistance was reflected in disadvantages suffered by Bt-resistant individuals feeding on a Bt diet instead of a non-Bt diet, including lower diapause propensity, lower diapause intensity and reduced longevity of overwintered male moths. While this study suggests that the evolution of resistance to Bt cotton and feeding on a Bt diet in Bt-resistant individuals have pervasive effects on several traits associated with diapause

  7. Fusion metrics for dynamic situation analysis

    NASA Astrophysics Data System (ADS)

    Blasch, Erik P.; Pribilski, Mike; Daughtery, Bryan; Roscoe, Brian; Gunsett, Josh

    2004-08-01

    To design information fusion systems, it is important to develop metrics as part of a test and evaluation strategy. In many cases, fusion systems are designed to (1) meet a specific set of user information needs (IN), (2) continuously validate information pedigree and updates, and (3) maintain this performance under changing conditions. A fusion system"s performance is evaluated in many ways. However, developing a consistent set of metrics is important for standardization. For example, many track and identification metrics have been proposed for fusion analysis. To evaluate a complete fusion system performance, level 4 sensor management and level 5 user refinement metrics need to be developed simultaneously to determine whether or not the fusion system is meeting information needs. To describe fusion performance, the fusion community needs to agree on a minimum set of metrics for user assessment and algorithm comparison. We suggest that such a minimum set should include feasible metrics of accuracy, confidence, throughput, timeliness, and cost. These metrics can be computed as confidence (probability), accuracy (error), timeliness (delay), throughput (amount) and cost (dollars). In this paper, we explore an aggregate set of metrics for fusion evaluation and demonstrate with information need metrics for dynamic situation analysis.

  8. Semantic Metrics for Object Oriented Design

    NASA Technical Reports Server (NTRS)

    Etzkorn, Lethe

    2003-01-01

    The purpose of this proposal is to research a new suite of object-oriented (OO) software metrics, called semantic metrics, that have the potential to help software engineers identify fragile, low quality code sections much earlier in the development cycle than is possible with traditional OO metrics. With earlier and better Fault detection, software maintenance will be less time consuming and expensive, and software reusability will be improved. Because it is less costly to correct faults found earlier than to correct faults found later in the software lifecycle, the overall cost of software development will be reduced. Semantic metrics can be derived from the knowledge base of a program understanding system. A program understanding system is designed to understand a software module. Once understanding is complete, the knowledge-base contains digested information about the software module. Various semantic metrics can be collected on the knowledge base. This new kind of metric measures domain complexity, or the relationship of the software to its application domain, rather than implementation complexity, which is what traditional software metrics measure. A semantic metric will thus map much more closely to qualities humans are interested in, such as cohesion and maintainability, than is possible using traditional metrics, that are calculated using only syntactic aspects of software.

  9. The Effect of Oxygen on Bile Resistance in Listeria monocytogenes

    PubMed Central

    Wright, Morgan L; Pendarvis, Ken; Nanduri, Bindu; Edelmann, Mariola J; Jenkins, Haley N; Reddy, Joseph S; Wilson, Jessica G; Ding, Xuan; Broadway, Paul R; Ammari, Mais G; Paul, Oindrila; Roberts, Brandy; Donaldson, Janet R

    2016-01-01

    Listeria monocytogenes is a Gram-positive facultative anaerobe that is the causative agent of the disease listeriosis. The infectious ability of this bacterium is dependent upon resistance to stressors encountered within the gastrointestinal tract, including bile. Previous studies have indicated bile salt hydrolase activity increases under anaerobic conditions, suggesting anaerobic conditions influence stress responses. Therefore, the goal of this study was to determine if reduced oxygen availability increased bile resistance of L. monocytogenes. Four strains representing three serovars were evaluated for changes in viability and proteome expression following exposure to bile in aerobic or anaerobic conditions. Viability for F2365 (serovar 4b), EGD-e (serovar 1/2a), and 10403S (serovar 1/2a) increased following exposure to 10% porcine bile under anaerobic conditions (P < 0.05). However, HCC23 (serovar 4a) exhibited no difference (P > 0.05) in bile resistance between aerobic and anaerobic conditions, indicating that oxygen availability does not influence resistance in this strain. The proteomic analysis indicated F2365 and EGD-e had an increased expression of proteins associated with cell envelope and membrane bioenergetics under anaerobic conditions, including thioredoxin-disulfide reductase and cell division proteins. Interestingly, HCC23 had an increase in several dehydrogenases following exposure to bile under aerobic conditions, suggesting that the NADH:NAD+ is altered and may impact bile resistance. Variations were observed in the expression of the cell shape proteins between strains, which corresponded to morphological differences observed by scanning electron microscopy. These data indicate that oxygen availability influences bile resistance. Further research is needed to decipher how these changes in metabolism impact pathogenicity in vivo and also the impact that this has on susceptibility of a host to listeriosis. PMID:27274623

  10. Effect of Trapped Energetic Particles on the Resistive Wall Mode

    SciTech Connect

    Hao, G. Z.; Wang, A. K.; Qiu, X. M.; Liu, Y. Q.

    2011-07-01

    A stability analysis for the resistive wall mode is studied in the presence of trapped energetic particles (EPs). When the EPs' beta exceeds a critical value, a fishbonelike bursting mode (FLM) with an external kink eigenstructure can exist. This offers the first analytic interpretation of the experimental observations [Phys. Rev. Lett. 103, 045001 (2009)]. The mode-particle resonances for the FLM and the q=1 fishbone occur in different regimes of the precession frequency of EPs. In certain ranges of the plasma rotation speed and the EPs' beta, a mode conversion can occur between the resistive wall mode and FLM.

  11. Comparing Prices for Food and Diet Research: The Metric Matters

    PubMed Central

    Jones, N. R. V.; Monsivais, P.

    2016-01-01

    ABSTRACT An important issue in research into access to healthy food is how best to compare the price of foods. The appropriate metric for comparison has been debated at length, with proponents variously stating that food prices should be compared in terms of their energy content, their edible mass, or their typical portion size. In this article we assessed the impact of using different food price metrics on the observed difference in price between food groups and categories of healthiness, using United Kingdom consumer price index data for 148 foods and beverages in 2012. We found that the choice of metric had a marked effect on the findings and conclude that this must be decided in advance to suit the reason for comparing food prices. PMID:27630754

  12. Non-minimal derivative couplings of the composite metric

    SciTech Connect

    Heisenberg, Lavinia

    2015-11-01

    In the context of massive gravity, bi-gravity and multi-gravity non-minimal matter couplings via a specific composite effective metric were investigated recently. Even if these couplings generically reintroduce the Boulware-Deser ghost, this composite metric is unique in the sense that the ghost reemerges only beyond the decoupling limit and the matter quantum loop corrections do not detune the potential interactions. We consider non-minimal derivative couplings of the composite metric to matter fields for a specific subclass of Horndeski scalar-tensor interactions. We first explore these couplings in the mini-superspace and investigate in which scenario the ghost remains absent. We further study these non-minimal derivative couplings in the decoupling-limit of the theory and show that the equation of motion for the helicity-0 mode remains second order in derivatives. Finally, we discuss preliminary implications for cosmology.

  13. Metrics for measuring net-centric data strategy implementation

    NASA Astrophysics Data System (ADS)

    Kroculick, Joseph B.

    2010-04-01

    An enterprise data strategy outlines an organization's vision and objectives for improved collection and use of data. We propose generic metrics and quantifiable measures for each of the DoD Net-Centric Data Strategy (NCDS) data goals. Data strategy metrics can be adapted to the business processes of an enterprise and the needs of stakeholders in leveraging the organization's data assets to provide for more effective decision making. Generic metrics are applied to a specific application where logistics supply and transportation data is integrated across multiple functional groups. A dashboard presents a multidimensional view of the current progress to a state where logistics data shared in a timely and seamless manner among users, applications, and systems.

  14. Eye Tracking Metrics for Workload Estimation in Flight Deck Operation

    NASA Technical Reports Server (NTRS)

    Ellis, Kyle; Schnell, Thomas

    2010-01-01

    Flight decks of the future are being enhanced through improved avionics that adapt to both aircraft and operator state. Eye tracking allows for non-invasive analysis of pilot eye movements, from which a set of metrics can be derived to effectively and reliably characterize workload. This research identifies eye tracking metrics that correlate to aircraft automation conditions, and identifies the correlation of pilot workload to the same automation conditions. Saccade length was used as an indirect index of pilot workload: Pilots in the fully automated condition were observed to have on average, larger saccadic movements in contrast to the guidance and manual flight conditions. The data set itself also provides a general model of human eye movement behavior and so ostensibly visual attention distribution in the cockpit for approach to land tasks with various levels of automation, by means of the same metrics used for workload algorithm development.

  15. Value-based metrics and Internet-based enterprises

    NASA Astrophysics Data System (ADS)

    Gupta, Krishan M.

    2001-10-01

    Within the last few years, a host of value-based metrics like EVA, MVA, TBR, CFORI, and TSR have evolved. This paper attempts to analyze the validity and applicability of EVA and Balanced Scorecard for Internet based organizations. Despite the collapse of the dot-com model, the firms engaged in e- commerce continue to struggle to find new ways to account for customer-base, technology, employees, knowledge, etc, as part of the value of the firm. While some metrics, like the Balance Scorecard are geared towards internal use, others like EVA are for external use. Value-based metrics are used for performing internal audits as well as comparing firms against one another; and can also be effectively utilized by individuals outside the firm looking to determine if the firm is creating value for its stakeholders.

  16. Non-minimal derivative couplings of the composite metric

    SciTech Connect

    Heisenberg, Lavinia

    2015-11-04

    In the context of massive gravity, bi-gravity and multi-gravity non-minimal matter couplings via a specific composite effective metric were investigated recently. Even if these couplings generically reintroduce the Boulware-Deser ghost, this composite metric is unique in the sense that the ghost reemerges only beyond the decoupling limit and the matter quantum loop corrections do not detune the potential interactions. We consider non-minimal derivative couplings of the composite metric to matter fields for a specific subclass of Horndeski scalar-tensor interactions. We first explore these couplings in the mini-superspace and investigate in which scenario the ghost remains absent. We further study these non-minimal derivative couplings in the decoupling-limit of the theory and show that the equation of motion for the helicity-0 mode remains second order in derivatives. Finally, we discuss preliminary implications for cosmology.

  17. Simulating the effects of bake process parameters on resist thermal reflow

    NASA Astrophysics Data System (ADS)

    Lee, Jae-Won; Feng, Zhaohua; Engelstad, Roxann L.; Lovell, Edward G.

    2004-12-01

    Producing smaller feature sizes by extending current and near-term lithographic printing tools is a cost-effective strategy for high-volume production of integrated circuits. The hardbake process, as an annealing step to strengthen resist structures, includes a desirable thermal reflow that can facilitate this objective. Thermal reflow of polymer-based resists is a phase-dependent phenomenon in which a polymeric material with recyclable / reversible thermal characteristics experiences dimensional changes through relaxation during thermal cycling at hardbake. Unlike polymer melts, resist reflow is accompanied by a continuous change in the physical state of the resist over a specific temperature range, so it can be described on the basis of the relaxation modulus-temperature relation. Resist behavior during thermal transitions (e.g., glassy, leathery, rubbery plateau, etc.) can effectively be classified into either solid or viscous, depending on whether the resist material is below or above the characteristic glass transition temperature. In general, resist contact hole size can be significantly reduced by optimizing the principal factors driving resist reflow, i.e., temperature-dependent material properties, bake cycle parameters, contact-hole dimensions, and the type of contact array. Recognizable size reduction of the contact hole appears as the resist passes through the leathery state, and its maximum permanent deformation after thermal cycling completely depends on the resist material used. This research focuses on a bake profile of the resist described by the parameters in typical three-stage proximity contact wafer processing. Simulation programs were developed to characterize the primary thermal properties and process parameters affecting the bake profile, and to identify their relative effects on the resist contact-hole response.

  18. Effects of quinidine and diphenylhydantoin on membrane resistance in smooth muscle.

    PubMed

    Melacini, P; Furlanut, M; Ferrari, M; Dalla Volta, S

    1975-01-01

    The effects of quinidine and diphenylhydantoin on the membrane electrical resistance of guinea-pig taenia coli have been studied by means of the double sucrose gap tachnique. At concentrations ranging from 2 to 7.10-minus 5 quinidine induces an evident dose-related increase of membrane resistance, as indicated by the increase of the electrotonic potential. These effects are unaffected by tetrodotoxin (10(-6)) and in the presence of various changes of ionic environment (replacement of Na by Li, increase of K or Ca or Mg concentrations). Only a concomitant rise of both K and Ca (or Mg) can prevent the effects of quinidine on membrane resistance. The rate of repetitive discharge under sustained electrical depolarization is not affected by quinidine, at concentrations increasing membrane resistance. The experiments with diphenylhydantoin showed that this drug is practically ineffective on membrane resistance, but induces a decrease of the rate of repetitive discharge under sustained depolarization.

  19. Distributed series resistance effects in solar cells: Dark and illuminated cases

    SciTech Connect

    Araujo, G.L.; Cuevas, A.; Ruiz, J.M.

    1984-05-01

    A new approach to calculate the distributed series resistance of a solar cell is presented. Since we include the contribution of the substrate resistance, our approach is more general than previous ones. Analytical solutions for the variation of r /SUB s/ for dark, short and open-circuit operation conditions are given. The authors show that the series resistance depends on flowing current and can be different in the dark and under illumination conditions, due to current crowding effects in the emitter layer. But it is also shown that this crowding can be significantly attenuated by the presence of substrate resistivity.

  20. Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting

    PubMed Central

    Yin, Yanan; Gu, Jie; Wang, Xiaojuan; Song, Wen; Zhang, Kaiyu; Sun, Wei; Zhang, Xin; Zhang, Yajun; Li, Haichao

    2017-01-01

    Copper is one of the most abundant heavy metals present in swine manure. In this study, a laboratory-scale aerobic composting system was amended with Cu at three levels (0, 200, and 2000 mg kg-1, i.e., control, Cu200, and Cu2000 treatments, respectively) to determine its effect on the fate of copper resistance genes [copper resistance genes (CRGs): pcoA, cusA, copA, and tcrB], antibiotic resistance genes [antibiotic resistance genes (ARGs): erm(A) and erm(B)], and intl1. The results showed that the absolute abundances of pcoA, tcrB, erm(A), erm(B), and intl1 were reduced, whereas those of copA and cusA increased after swine manure composting. Redundancy analysis showed that temperature significantly affected the variations in CRGs, ARGs, and intl1. The decreases in CRGs, ARGs, and intI1 were positively correlated with the exchangeable Cu levels. The bacterial community could be grouped according to the composting time under different treatments, where the high concentration of copper had a more persistent effect on the bacterial community. Network analysis determined that the co-occurrence of CRGs, ARGs, and intI1, and the bacterial community were the main contributors to the changes in CRGs, ARG, and intl1. Thus, temperature, copper, and changes in the bacterial community composition had important effects on the variations in CRGs, ARGs, and intl1 during manure composting in the presence of added copper. PMID:28316595

  1. Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting.

    PubMed

    Yin, Yanan; Gu, Jie; Wang, Xiaojuan; Song, Wen; Zhang, Kaiyu; Sun, Wei; Zhang, Xin; Zhang, Yajun; Li, Haichao

    2017-01-01

    Copper is one of the most abundant heavy metals present in swine manure. In this study, a laboratory-scale aerobic composting system was amended with Cu at three levels (0, 200, and 2000 mg kg(-1), i.e., control, Cu200, and Cu2000 treatments, respectively) to determine its effect on the fate of copper resistance genes [copper resistance genes (CRGs): pcoA, cusA, copA, and tcrB], antibiotic resistance genes [antibiotic resistance genes (ARGs): erm(A) and erm(B)], and intl1. The results showed that the absolute abundances of pcoA, tcrB, erm(A), erm(B), and intl1 were reduced, whereas those of copA and cusA increased after swine manure composting. Redundancy analysis showed that temperature significantly affected the variations in CRGs, ARGs, and intl1. The decreases in CRGs, ARGs, and intI1 were positively correlated with the exchangeable Cu levels. The bacterial community could be grouped according to the composting time under different treatments, where the high concentration of copper had a more persistent effect on the bacterial community. Network analysis determined that the co-occurrence of CRGs, ARGs, and intI1, and the bacterial community were the main contributors to the changes in CRGs, ARG, and intl1. Thus, temperature, copper, and changes in the bacterial community composition had important effects on the variations in CRGs, ARGs, and intl1 during manure composting in the presence of added copper.

  2. Effects of three novel resistant black raspberry selections on Amphorophora agathonica feeding behavior and performance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Host plant resistance is a practical and cost-effective approach for growers to manage insect pests. Recently, three new sources of resistance in black raspberry (selections ORUS 3778-1, ORUS 3817-1, and ORUS 4109-1) against the large raspberry aphid, Amphorophora agathonica, were identified. We stu...

  3. Generalized Resistance to the Effects of Psychological Stressors

    ERIC Educational Resources Information Center

    Terris, William; Rahhal, Don K.

    1969-01-01

    Studies the ability of college women to generalize resistance to stress when learning lists of nonsense syllables. Subjects trained under one type of stress learned more easily under a second type of stress than did subjects trained under nonstressful conditions. Table, graph, and bibliography. (RW)

  4. Effects of Behavioral History on Resistance to Change

    ERIC Educational Resources Information Center

    Doughty, Adam H.; Cirino, Sergio; Mayfield, Kristin H.; da Silva, Stephanie P.; Okouchi, Hiroto; Lattal, Kennon A.

    2005-01-01

    Two experiments examined whether differential resistance to change would occur under identical variable-interval schedules as a function of a differential behavioral history. In Experiment 1, each of 3 pigeons first pecked at different rates under a multiple variable-ratio differential-reinforcement-of-low-rate schedule. In a subsequent condition,…

  5. Cost Effective Approaches to Impart Flame Resistance to Cotton Nonwovens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recent changes in the flammability laws require improvements in the flame resistance of cotton-containing consumer goods such as upholstered furniture, mattresses, and pillows. Cotton, synthetic fibers, fabrics, and foam are the basic constituents of these goods, often the first to engulf by a fire....

  6. The Effect of Resistance on Rocket Injector Acoustics

    NASA Technical Reports Server (NTRS)

    Morgan, C. J.

    2015-01-01

    Combustion instability, where unsteady heat release couples with acoustic modes, has long been an area of concern in liquid rocket engines. Accurate modeling of the acoustic normal modes of the combustion chamber is important to understanding and preventing combustion instability. The injector resistance can have a significant influence on the chamber normal mode shape, and hence on the system stability.

  7. Effects of Microneedle Design Parameters on Hydraulic Resistance.

    PubMed

    Hood, R Lyle; Kosoglu, Mehmet A; Parker, Matthew; Rylander, Christopher G

    2011-09-01

    Microneedles have been an expanding medical technology in recent years due to their ability to penetrate tissue and deliver therapy with minimal invasiveness and patient discomfort. Variations in design have allowed for enhanced fluid delivery, biopsy collection, and the measurement of electric potentials. Our novel microneedle design attempts to combine many of these functions into a single length of silica tubing capable of both light and fluid delivery terminating in a sharp tip of less than 100 microns in diameter. This manuscript focuses on the fluid flow aspects of the design, characterizing the contributions to hydraulic resistance from the geometric parameters of the microneedles. Experiments consisted of measuring the volumetric flow rate of de-ionized water at set pressures (ranging from 69-621 kPa) through a relevant range of tubing lengths, needle lengths, and needle tip diameters. Data analysis showed that the silica tubing (~150 micron bore diameter) adhered to within ±5% of the theoretical prediction by Poiseuille's Law describing laminar internal pipe flow at Reynolds numbers less than 700. High hydraulic resistance within the microneedles correlated with decreasing tip diameter. The hydraulic resistance offered by the silica tubing preceding the microneedle taper was approximately 1-2 orders of magnitude less per unit length, but remained the dominating resistance in most experiments as the tubing length was >30 mm. These findings will be incorporated into future design permutations to produce a microneedle capable of both efficient fluid transfer and light delivery.

  8. Effects of halides on plasmid-mediated silver resistance in Escherichia coli

    SciTech Connect

    Gupta, A.; Maynes, M.; Silver, S.

    1998-12-01

    Silver resistance of sensitive Escherichia coli J53 and resistance plasmid-containing J53(pMG101) was affected by halides in the growth medium. The effects of halides on Ag{sup +} resistance were measured with AgNO{sub 3} and silver sulfadiazine, both on agar and in liquid. Low concentrations of chloride made the differences in MICs between sensitive and resistant strains larger. High concentrations of halides increased the sensitivities of both strains to Ag{sup +}. The purpose of this report is to set out easy-to-use conditions for measuring silver sensitivity and resistance in familiar and widely used media, Luria-Bertani (LB) agar and broth, so as to facilitate wider identification of silver resistance in nature.

  9. Metric Learning to Enhance Hyperspectral Image Segmentation

    NASA Technical Reports Server (NTRS)

    Thompson, David R.; Castano, Rebecca; Bue, Brian; Gilmore, Martha S.

    2013-01-01

    Unsupervised hyperspectral image segmentation can reveal spatial trends that show the physical structure of the scene to an analyst. They highlight borders and reveal areas of homogeneity and change. Segmentations are independently helpful for object recognition, and assist with automated production of symbolic maps. Additionally, a good segmentation can dramatically reduce the number of effective spectra in an image, enabling analyses that would otherwise be computationally prohibitive. Specifically, using an over-segmentation of the image instead of individual pixels can reduce noise and potentially improve the results of statistical post-analysis. In this innovation, a metric learning approach is presented to improve the performance of unsupervised hyperspectral image segmentation. The prototype demonstrations attempt a superpixel segmentation in which the image is conservatively over-segmented; that is, the single surface features may be split into multiple segments, but each individual segment, or superpixel, is ensured to have homogenous mineralogy.

  10. Effects of Temperature on Resistance in Phaseolus vulgaris Genotypes and on Development of Meloidogyne Species

    PubMed Central

    Sydenham, G. M.; McSorley, R.; Dunn, R. A.

    1997-01-01

    Phaseolus vulgaris lines with heat-stable resistance to Meloidogyne spp. may be needed to manage root-knot nematodes in tropical regions. Resistance expression before and during the process of nematode penetration and development in resistant genotypes were studied at pre- and postinoculation temperatures of 24 °C and 24 °C, 24 °C and 28 °C, 28 °C and 24 °C, and 28 °C and 28 °C. Resistance was effective at all temperature regimes examined, with fewer nematodes in roots of a resistant line compared with a susceptible line. Preinoculation temperature did not modify resistance expression to later infections by root-knot nematodes. However, postinoculation temperatures affected development of Meloidogyne spp. in both the resistant and susceptible bean lines tested. The more rapid development of nematodes to adults at the higher postinoculation temperature of 28 °C in both bean lines suggests direct temperature effects on nematode development instead of on resistance expression of either of two gene systems. Also, resistance was stable at 30 °C and 32 °C. PMID:19274137

  11. Metrical Segmentation in Dutch: Vowel Quality or Stress?

    ERIC Educational Resources Information Center

    Quene, Hugo; Koster, Mariette L.

    1998-01-01

    Examines metrical segmentation strategy in Dutch. The first experiment shows that stress strongly affects Dutch listeners' ability and speed in spotting Dutch monosyllabic words in disyllabic nonwords. The second experiment finds the same stress effect when only the target words are presented without a subsequent syllable triggering segmentation.…

  12. In Transit...Making the Change to Metrics.

    ERIC Educational Resources Information Center

    Farnsworth, Briant J.; And Others

    1980-01-01

    Granite School District (Utah) developed a systematic, effective, and cost-efficient teacher inservice program which provides a basic understanding of metrics, materials and methods for direct classroom use, and evaluation of the learning process, through the use of self-contained, three-phase modules for home or school use. (Author/SB)

  13. ELECTROFISHING IN BOATABLE RIVERS: DOES SAMPLING DESIGN AFFECT BIOASSESSMENT METRICS?

    EPA Science Inventory

    Data were collected from 60 boatable sites using an electrofishing design that permitted comparisons of the effects of designs and distances on fish assemblage metrics. Sites were classified a priori as Run-of-the-River (ROR) or Restricted Flow (RF). Data representing four diff...

  14. Elementary Metric Curriculum - Project T.I.M.E. (Timely Implementation of Metric Education). Part I.

    ERIC Educational Resources Information Center

    Community School District 18, Brooklyn, NY.

    This is a teacher's manual for an ISS-based elementary school course in the metric system. Behavioral objectives and student activities are included. The topics covered include: (1) linear measurement; (2) metric-decimal relationships; (3) metric conversions; (4) geometry; (5) scale drawings; and (6) capacity. This is the first of a two-part…

  15. Costs of Emission Metrics in the Context of Climate Stabilizations

    NASA Astrophysics Data System (ADS)

    Tanaka, Katsumasa; Johansson, Daniel; O'Neill, Brian; Fuglestvedt, Jan

    2014-05-01

    The United Nations Framework Convention on Climate Change (UNFCCC) calls for stabilization of greenhouse gas (GHG) concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system (Article 2) and stipulates that policies and measures should cover all relevant sources, sinks and reservoirs of greenhouse gases (Article 3.3). An emission metric to evaluate emissions of non-CO2 gases on a common scale of CO2 is critical for climate policymaking and also essential in a single basket approach to GHG emission abatement to achieve climate stabilization (for example, at 2°C warming target as recognized in the Cancún Agreements). While the Global Warming Potential (GWP) is by far the most common metric used in climate policies (e.g. Kyoto Protocol), alternative metrics are proposed to overcome deficiencies in the GWP. Those include the Cost-Effective Temperature Potential (CETP), Forcing Equivalent Index (FEI), Global Cost Potential (GCP), Global Damage Potential (GDP), Global Temperature change Potential (GTP), Mean Global Temperature change Potential (MGTP), Peak Commitment Temperature (PCT), Regional Temperature change Potential (RTP), Sustained Emission Temperature (SET), and TEMperature Proxy index (TEMP). A number of studies provide estimates of such metrics for different gases under a variety of assumptions and approaches. It has been demonstrated that emission metrics take a large range of values when compared in the context of climate stabilization, depending largely on the metric structure and the treatment of the time dimension. On the contrary, the differences in stabilization costs arising from the choice of metrics are shown to be disproportionally small in both cost-effectiveness and cost-benefit frameworks (i.e. a few to several percent higher costs relative to those based on optimal price ratios). However, only a limited set of metrics has been a subject of cost estimation and such calculations

  16. Resistance-resistant antibiotics.

    PubMed

    Oldfield, Eric; Feng, Xinxin

    2014-12-01

    New antibiotics are needed because drug resistance is increasing while the introduction of new antibiotics is decreasing. We discuss here six possible approaches to develop 'resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier to develop than conventional combination therapies with two new drugs. Second, inhibiting multiple targets in the same metabolic pathway is expected to be an effective strategy owing to synergy. Third, discovering multiple-target inhibitors should be possible by using sequential virtual screening. Fourth, repurposing existing drugs can lead to combinations of multitarget therapeutics. Fifth, targets need not be proteins. Sixth, inhibiting virulence factor formation and boosting innate immunity may also lead to decreased susceptibility to resistance. Although it is not possible to eliminate resistance, the approaches reviewed here offer several possibilities for reducing the effects of mutations and, in some cases, suggest that sensitivity to existing antibiotics may be restored in otherwise drug-resistant organisms.

  17. Metrics for Automotive Merchandising, Petroleum Marketing.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of students in automotive merchandising and petroleum marketing classes, this instructional package is one of five for the marketing and distribution cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know…

  18. Metrication and Dimensional Coordination - A Selected Bibliography.

    ERIC Educational Resources Information Center

    Clark, Roy E.; Roat Candace L.

    The United States changeover to the use of the SI (International Metric) measurement language presents the construction industry with the need to review and adapt many product standards and practices for the use of metric measurement units. These adaptations and changes can bring substantial benefits to the industry in the form of permanently…

  19. A Complexity Metric for Automated Separation

    NASA Technical Reports Server (NTRS)

    Aweiss, Arwa

    2009-01-01

    A metric is proposed to characterize airspace complexity with respect to an automated separation assurance function. The Maneuver Option metric is a function of the number of conflict-free trajectory change options the automated separation assurance function is able to identify for each aircraft in the airspace at a given time. By aggregating the metric for all aircraft in a region of airspace, a measure of the instantaneous complexity of the airspace is produced. A six-hour simulation of Fort Worth Center air traffic was conducted to assess the metric. Results showed aircraft were twice as likely to be constrained in the vertical dimension than the horizontal one. By application of this metric, situations found to be most complex were those where level overflights and descending arrivals passed through or merged into an arrival stream. The metric identified high complexity regions that correlate well with current air traffic control operations. The Maneuver Option metric did not correlate with traffic count alone, a result consistent with complexity metrics for human-controlled airspace.

  20. Metrics for Offset Printing Press Operation.

    ERIC Educational Resources Information Center

    Cooper, Gloria S., Ed.; Magisos, Joel H., Ed.

    Designed to meet the job-related metric measurement needs of offset printing press operation students, this instructional package is one of six for the communication media occupations cluster, part of a set of 55 packages for metric instruction in different occupations. The package is intended for students who already know the occupational…

  1. Advanced Life Support System Value Metric

    NASA Technical Reports Server (NTRS)

    Jones, Harry W.; Rasky, Daniel J. (Technical Monitor)

    1999-01-01

    The NASA Advanced Life Support (ALS) Program is required to provide a performance metric to measure its progress in system development. Extensive discussions within the ALS program have led to the following approach. The Equivalent System Mass (ESM) metric has been traditionally used and provides a good summary of the weight, size, and power cost factors of space life support equipment. But ESM assumes that all the systems being traded off exactly meet a fixed performance requirement, so that the value and benefit (readiness, performance, safety, etc.) of all the different systems designs are considered to be exactly equal. This is too simplistic. Actual system design concepts are selected using many cost and benefit factors and the system specification is defined after many trade-offs. The ALS program needs a multi-parameter metric including both the ESM and a System Value Metric (SVM). The SVM would include safety, maintainability, reliability, performance, use of cross cutting technology, and commercialization potential. Another major factor in system selection is technology readiness level (TRL), a familiar metric in ALS. The overall ALS system metric that is suggested is a benefit/cost ratio, SVM/[ESM + function (TRL)], with appropriate weighting and scaling. The total value is given by SVM. Cost is represented by higher ESM and lower TRL. The paper provides a detailed description and example application of a suggested System Value Metric and an overall ALS system metric.

  2. Handbook for Metric Usage (First Edition).

    ERIC Educational Resources Information Center

    American Home Economics Association, Washington, DC.

    Guidelines for changing to the metric system of measurement with regard to all phases of home economics are presented in this handbook. Topics covered include the following: (1) history of the metric system, (2) the International System of Units (SI): derived units of length, mass, time, and electric current; temperature; luminous intensity;…

  3. Particle dynamics in the original Schwarzschild metric

    NASA Astrophysics Data System (ADS)

    Fimin, N. N.; Chechetkin, V. M.

    2016-04-01

    The properties of the original Schwarzschild metric for a point gravitating mass are considered. The laws of motion in the corresponding space-time are established, and the transition from the Schwarzschildmetric to the metric of a "dusty universe" are studied. The dynamics of a system of particles in thr post-Newtonian approximation are analyzed.

  4. Imbedding Locally Euclidean and Conformally Euclidean Metrics

    NASA Astrophysics Data System (ADS)

    Aleksandrov, V. A.

    1992-02-01

    The possibility of imbedding n-dimensional locally Euclidean metrics in the large in Rn is studied by means of the global inverse function theorem in the forms suggested by Hadamard, John, Levy and Plastock. The imbeddability of conformally Euclidean metrics is studied by means of a theorem of Zorich on the removability of an isolated singularity of a locally quasiconformal mapping.

  5. Ranking streamflow model performance based on Information theory metrics

    NASA Astrophysics Data System (ADS)

    Martinez, Gonzalo; Pachepsky, Yakov; Pan, Feng; Wagener, Thorsten; Nicholson, Thomas

    2016-04-01

    The accuracy-based model performance metrics not necessarily reflect the qualitative correspondence between simulated and measured streamflow time series. The objective of this work was to use the information theory-based metrics to see whether they can be used as complementary tool for hydrologic model evaluation and selection. We simulated 10-year streamflow time series in five watersheds located in Texas, North Carolina, Mississippi, and West Virginia. Eight model of different complexity were applied. The information-theory based metrics were obtained after representing the time series as strings of symbols where different symbols corresponded to different quantiles of the probability distribution of streamflow. The symbol alphabet was used. Three metrics were computed for those strings - mean information gain that measures the randomness of the signal, effective measure complexity that characterizes predictability and fluctuation complexity that characterizes the presence of a pattern in the signal. The observed streamflow time series has smaller information content and larger complexity metrics than the precipitation time series. Watersheds served as information filters and and streamflow time series were less random and more complex than the ones of precipitation. This is reflected the fact that the watershed acts as the information filter in the hydrologic conversion process from precipitation to streamflow. The Nash Sutcliffe efficiency metric increased as the complexity of models increased, but in many cases several model had this efficiency values not statistically significant from each other. In such cases, ranking models by the closeness of the information-theory based parameters in simulated and measured streamflow time series can provide an additional criterion for the evaluation of hydrologic model performance.

  6. New Family of Generalized Metrics for Comparative Imaging System Evaluation

    PubMed Central

    Russ, M.; Singh, V.; Loughran, B.; Bednarek, D.R.; Rudin, S.

    2015-01-01

    A family of imaging task-specific metrics designated Relative Object Detectability (ROD) metrics was developed to enable objective, quantitative comparisons of different x-ray systems. Previously, ROD was defined as the integral over spatial frequencies of the Fourier Transform of the object function, weighted by the detector DQE for one detector, divided by the comparable integral for another detector. When effects of scatter and focal spot unsharpness are included, the generalized metric, GDQE, is substituted for the DQE, resulting in the G-ROD metric. The G-ROD was calculated for two different detectors with two focal spot sizes using various-sized simulated objects to quantify the improved performance of new high-resolution CMOS detector systems. When a measured image is used as the object, a Generalized Measured Relative Object Detectability (GM-ROD) value can be generated. A neuro-vascular stent (Wingspan) was imaged with the high-resolution Micro-Angiographic Fluoroscope (MAF) and a standard flat panel detector (FPD) for comparison using the GM-ROD calculation. As the lower integration bound increased from 0 toward the detector Nyquist frequency, increasingly superior performance of the MAF was evidenced. Another new metric, the R-ROD, enables comparing detectors to a reference detector of given imaging ability. R-RODs for the MAF, a new CMOS detector and an FPD will be presented. The ROD family of metrics can provide quantitative more understandable comparisons for different systems where the detector, focal spot, scatter, object, techniques or dose are varied and can be used to optimize system selection for given imaging tasks. PMID:26912942

  7. New family of generalized metrics for comparative imaging system evaluation

    NASA Astrophysics Data System (ADS)

    Russ, M.; Singh, V.; Loughran, B.; Bednarek, D. R.; Rudin, S.

    2015-03-01

    A family of imaging task-specific metrics designated Relative Object Detectability (ROD) metrics was developed to enable objective, quantitative comparisons of different x-ray systems. Previously, ROD was defined as the integral over spatial frequencies of the Fourier Transform of the object function, weighted by the detector DQE for one detector, divided by the comparable integral for another detector. When effects of scatter and focal spot unsharpness are included, the generalized metric, GDQE, is substituted for the DQE, resulting in the G-ROD metric. The G-ROD was calculated for two different detectors with two focal spot sizes using various-sized simulated objects to quantify the improved performance of new high-resolution CMOS detector systems. When a measured image is used as the object, a Generalized Measured Relative Object Detectability (GM-ROD) value can be generated. A neuro-vascular stent (Wingspan) was imaged with the high-resolution Micro-Angiographic Fluoroscope (MAF) and a standard flat panel detector (FPD) for comparison using the GM-ROD calculation. As the lower integration bound increased from 0 toward the detector Nyquist frequency, increasingly superior performance of the MAF was evidenced. Another new metric, the R-ROD, enables comparing detectors to a reference detector of given imaging ability. R-RODs for the MAF, a new CMOS detector and an FPD will be presented. The ROD family of metrics can provide quantitative more understandable comparisons for different systems where the detector, focal spot, scatter, object, techniques or dose are varied and can be used to optimize system selection for given imaging tasks.

  8. Indicators and metrics for the assessment of climate engineering

    NASA Astrophysics Data System (ADS)

    Oschlies, A.; Held, H.; Keller, D.; Keller, K.; Mengis, N.; Quaas, M.; Rickels, W.; Schmidt, H.

    2017-01-01

    Selecting appropriate indicators is essential to aggregate the information provided by climate model outputs into a manageable set of relevant metrics on which assessments of climate engineering (CE) can be based. From all the variables potentially available from climate models, indicators need to be selected that are able to inform scientists and society on the development of the Earth system under CE, as well as on possible impacts and side effects of various ways of deploying CE or not. However, the indicators used so far have been largely identical to those used in climate change assessments and do not visibly reflect the fact that indicators for assessing CE (and thus the metrics composed of these indicators) may be different from those used to assess global warming. Until now, there has been little dedicated effort to identifying specific indicators and metrics for assessing CE. We here propose that such an effort should be facilitated by a more decision-oriented approach and an iterative procedure in close interaction between academia, decision makers, and stakeholders. Specifically, synergies and trade-offs between social objectives reflected by individual indicators, as well as decision-relevant uncertainties should be considered in the development of metrics, so that society can take informed decisions about climate policy measures under the impression of the options available, their likely effects and side effects, and the quality of the underlying knowledge base.

  9. Effects of silicon on plant resistance to environmental stresses: review

    NASA Astrophysics Data System (ADS)

    Balakhnina, T.; Borkowska, A.

    2013-03-01

    The role of exogenous silicon in enhancing plant resistance to various abiotic stressors: salinity, drought, metal toxicities and ultraviolet radiation are presented. The data on possible involvement of silicon in reducing the reactive oxygen species generation, intensity of lipid peroxidation, and in some cases, increasing the activity of enzymes of the reactive oxygen species detoxificators: superoxide dismutase, ascorbate peroxidase, glutathione reductase, guaiacol peroxidase and catalase are analyzed.

  10. Structures to Resist the Effects of Accidental Explosions

    DTIC Science & Technology

    1990-11-01

    construction economy. Construction costs are divided between labor and material costs. Labor cost is further divided into shop and field work, with...field labor being generally the more costly. Labor cost can account for as mush as 70% of the cost of blast resistant reinforced concrete. Proper...1itle reducing the overall construc- tion cost by reducing labor I:nzcnsive a.tiv!ties. In addition, improved constructability greatly -educes tixe

  11. Program for implementing software quality metrics

    SciTech Connect

    Yule, H.P.; Riemer, C.A.

    1992-04-01

    This report describes a program by which the Veterans Benefit Administration (VBA) can implement metrics to measure the performance of automated data systems and demonstrate that they are improving over time. It provides a definition of quality, particularly with regard to software. Requirements for management and staff to achieve a successful metrics program are discussed. It lists the attributes of high-quality software, then describes the metrics or calculations that can be used to measure these attributes in a particular system. Case studies of some successful metrics programs used by business are presented. The report ends with suggestions on which metrics the VBA should use and the order in which they should be implemented.

  12. Smart Grid Status and Metrics Report Appendices

    SciTech Connect

    Balducci, Patrick J.; Antonopoulos, Chrissi A.; Clements, Samuel L.; Gorrissen, Willy J.; Kirkham, Harold; Ruiz, Kathleen A.; Smith, David L.; Weimar, Mark R.; Gardner, Chris; Varney, Jeff

    2014-07-01

    A smart grid uses digital power control and communication technology to improve the reliability, security, flexibility, and efficiency of the electric system, from large generation through the delivery systems to electricity consumers and a growing number of distributed generation and storage resources. To convey progress made in achieving the vision of a smart grid, this report uses a set of six characteristics derived from the National Energy Technology Laboratory Modern Grid Strategy. The Smart Grid Status and Metrics Report defines and examines 21 metrics that collectively provide insight into the grid’s capacity to embody these characteristics. This appendix presents papers covering each of the 21 metrics identified in Section 2.1 of the Smart Grid Status and Metrics Report. These metric papers were prepared in advance of the main body of the report and collectively form its informational backbone.

  13. Automated Neuropsychological Assessment Metrics Version 4 (ANAM4): Select Psychometric Properties and Administration Procedures

    DTIC Science & Technology

    2015-12-01

    Award Number: W81XWH-08-1-0021 TITLE: Automated Neuropsychological Assessment Metrics Version 4 (ANAM4): Select Psychometric Properties and...REPORT DATE December 2015 2. REPORT TYPE Annual 3. DATES COVERED 01 Dec 2014 – 30 Nov 2015 4. TITLE AND SUBTITLE Automated Neuropsychological ... Neuropsychological Assessment Metrics (ANAM) is a computer assisted tool for evaluating neurocognitive performance with demonstrated effectiveness

  14. Effect of resistance training on strength, postural control, and gait velocity among older adults.

    PubMed

    Topp, R; Mikesky, A; Dayhoff, N E; Holt, W

    1996-11-01

    The purpose of this study was to examine the effects of a 14-week resistance training program on the ankle strength, training intensity, postural control, and gait velocity of older adults. Forty-two older adults (mean age = 72), 21 in the resistance and control groups, completed the 14-week project. The resistance training group participated in 14 weeks of resistance training three times per week using elastic bands (Theraband) for resistance. Isokinetic ankle strength, training intensity, postural stability, and gait velocity were measured prior to and following the 14-week intervention. Following the training, the resistance group exhibited improved ankle dorsiflexion, training resistances, and gait velocity, but showed no change in plantar flexion or postural control. The control group also exhibited improvements in dorsiflexion, but these gains were approximately one-half of the gains observed in the resistance training group. Finally, when adjusted for baseline differences, subjects in the resistance training group demonstrated no changes in the dependent measures over the control group.

  15. Effects of sodium chlorate on antibiotic resistance in Escherichia coli O157:H7.

    PubMed

    Callaway, T R; Anderson, R C; Edrington, T S; Bischoff, K M; Genovese, K J; Poole, T L; Byrd, J A; Harvey, R B; Nisbet, D J

    2004-01-01

    The spread of antibiotic resistance from farm animals to human pathogens has become a matter of great public health significance, and methods to reduce foodborne pathogenic bacteria without utilizing traditional antibiotics have been sought. Chlorate kills Escherichia coli O157:H7 in vitro and in vivo and has been proposed as a feed additive to be included in food animal rations immediately prior to slaughter to reduce E. coli O157:H7 populations in the animal gastrointestinal tract. This study was designed to examine the effect that the development of chlorate resistance in E. coli O157:H7 has on resistance to 32 medically important antibiotics. Chlorate resistance numerically increased antibiotic resistance in E. coli O157:H7 strain 6058 and strain 933 to six and four antibiotics, respectively, but chlorate resistance affected resistance to only two antibiotics (cefoxotin and sulfadimethoxine) in both strains examined. Based on the fact that chlorate resistant mutants do not appear to compete well in vivo and based on the results of the current study, it appears unlikely that chlorate treatment will result in a dissemination of antibiotic resistance. However, further research is needed to confirm these results.

  16. Effectiveness of Antipseudomonal Antibiotics and Mechanisms of Multidrug Resistance in Pseudomonas aeruginosa.

    PubMed

    El ZOWALATYl, Mohamed E; Gyetvaii, Bpla

    2016-01-01

    Pseudomonas aeruginosa is a leading human pathogen that causes serious infections at various tissues and organs leading to life threatening health problems and possible deadly outcomes. Resistance patterns vary widely whether it is from hospitals or community acquired infections. Reporting resistance profiles to a certain antibiotics provide valuable information in a given setting, but may be extrapolated outside the sampling location. In the present study, P. aeruginosa isolates were screened to determine their susceptibilities against anti-pseudomonal antimicrobial agents and possible existing mechanisms of resistance were determined. Eighty-six isolates of P. aeruginosa were recovered. Isolates representing different resistance profiles were screened for the existence of three different resistance mechanisms including drug inactivation due to metallo-β-lactamases, drug impermeability by outer membrane proteins and drug efflux. All tested isolates showed uniform susceptibility (100%, n = 86/86) to piperacillin, meropenem, amikacin, and polymyxin B. A single isolate was found to be imipenem resistant (99%, n = 85/86). The possible mechanisms of resistance of P. aeruginosa to imipenem involve active drug efflux pumps, outer membrane impermeability as well as drug inactivating enzymes. These findings demonstrate the fundamental importance of the in vitro susceptibility testing of antibiotics prior to antipseudomonal therapy and highlight the need for a continuous antimicrobial resistance surveillance programs to monitor the changing resistance patterns so that clinicians and health care officials are updated as to the most effective therapeutic agents to combat the serious outcomes of P. aeruginosa infections.

  17. Terrain analysis from visibility metrics

    NASA Astrophysics Data System (ADS)

    Richbourg, Robert F.; Ray, Clark; Campbell, Larry L.

    1995-07-01

    Terrain analysis in support of planned military training or operations in a task which requires considerably training, skill, and experience. Military planners must synthesize knowledge of both their own and their expected adversary's tactics, weapons systems, and probable courses of action to determine key terrain, those portions of the terrain surface which have the most impact on the conduct of tactical operations. Many attributes of the actual terrain influence terrain analyses. These include elevation, intervisibility, vegetation cover, transportation networks, waterways, trafficability, soil types, and others. In some important areas of the world, the large set of attributes that influence terrain analysis is greatly reduced. Desert areas comprise one such areal class. As an example, a high resolution digital elevation model is sufficient to support most terrain analysis efforts for platoon and company operations in the US Marine Corps' dismounted infantry training area at 29 Palms, California. The digital elevation model allows an analysis to characterize each point in the model according to an approximate relative-visibility metric. Determination of key terrain, siting of probable defensive positions, and identification of highly concealed avenues of approach flow from examination of the resulting visibility model. These tactically significant areas can be used to conduct operations planning, perform DEM resolution studies, or help determine selective fidelity parameters for TIN modeling purposes.

  18. Metrics for border management systems.

    SciTech Connect

    Duggan, Ruth Ann

    2009-07-01

    There are as many unique and disparate manifestations of border systems as there are borders to protect. Border Security is a highly complex system analysis problem with global, regional, national, sector, and border element dimensions for land, water, and air domains. The complexity increases with the multiple, and sometimes conflicting, missions for regulating the flow of people and goods across borders, while securing them for national security. These systems include frontier border surveillance, immigration management and customs functions that must operate in a variety of weather, terrain, operational conditions, cultural constraints, and geopolitical contexts. As part of a Laboratory Directed Research and Development Project 08-684 (Year 1), the team developed a reference framework to decompose this complex system into international/regional, national, and border elements levels covering customs, immigration, and border policing functions. This generalized architecture is relevant to both domestic and international borders. As part of year two of this project (09-1204), the team determined relevant relative measures to better understand border management performance. This paper describes those relative metrics and how they can be used to improve border management systems.

  19. Effect of Electromagnetic Treatment on Fatigue Resistance of 2011 Aluminum Alloy

    NASA Astrophysics Data System (ADS)

    Mohin, M. A.; Toofany, H.; Babutskyi, A.; Lewis, A.; Xu, Y. G.

    2016-08-01

    Beneficial effects of the electromagnetic treatment on fatigue resistance were reported on several engineering alloys. These could be linked to the dislocation activity and the rearrangement of the crystal structure of the material under the electromagnetic field (EMF), resulting in delayed crack initiation. This paper presents an experimental study on the effect of pulsed electromagnetic treatment on the fatigue resistance of 2011 aluminum alloy. Circular cantilever specimens with loads at their ends were tested on rotating fatigue machine SM1090. Fatigue lives of treated and untreated specimens were analyzed and compared systematically. It has been found that the effect of the pulsed electromagnetic treatment on the fatigue resistance is dependent on the intensity of the pulsed EMF and the number of the treatment applied. Clear beneficial effect of the pulsed electromagnetic treatment on the fatigue resistance of the aluminum alloys has been observed, demonstrating a potential new technique to industries for fatigue life extension.

  20. Residual stress effects on the impact resistance and strength of fiber composites

    NASA Technical Reports Server (NTRS)

    Chamis, C. C.

    1973-01-01

    Equations have been derived to predict degradation effects of microresidual stresses on impact resistance of unidirectional fiber composites. Equations also predict lamination residual stresses in multilayered angle ply composites.

  1. Stochastic effects in 11 nm imaging of extreme ultraviolet lithography with chemically amplified resists

    NASA Astrophysics Data System (ADS)

    Kozawa, Takahiro; Santillan, Julius Joseph; Itani, Toshiro

    2014-03-01

    The resolution of extreme ultraviolet (EUV) lithography with chemically amplified resist processes has reached 16 nm (half-pitch). The development of chemically amplified resists is ongoing toward the 11 nm node. However, the stochastic effects are increasingly becoming a significant concern with the continuing shrinkage of features. In this study, the fluctuation of protected unit distribution caused by the stochastic effects during image formation was investigated assuming line-and-space patterns with 11 nm half-pitch. Contrary to expectations, the standard deviation of the number of protected units connected to a polymer after postexposure baking (PEB) did not differ from that for 16 nm half-pitch. The standard deviation after PEB increased with the effective reaction radius for deprotection and the initial standard deviation before PEB. Because of the severe requirements for resist processes, the stochastic effects in chemical reactions should be taken into account in the design of next-generation resists.

  2. Predicting the acute behavioral effects in rats inhaling toluene for up to 24 hrs: Inhaled vs, internal dose metrics and tolerance.

    EPA Science Inventory

    The acute toxicity of toluene, a model volatile organic compound (VOC), depends on the concentration (C) and duration (t) of exposure, and guidelines for acute exposures have traditionally used extrelationships to extrapolate protective and/or effective concentrations across dura...

  3. Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells.

    PubMed

    Lavie, Y; Harel-Orbital, T; Gaffield, W; Liscovitch, M

    2001-01-01

    Intrinsic or acquired resistance of tumor cells to multiple cytotoxic drugs (multidrug resistance MDR) is a major cause of failure of cancer chemotherapy. MDR is often caused by elevated expression of drug transporters such as P-glycoprotein (P-gp) or multidrug resistance protein (MRP). A number of compounds, termed chemosensitizers, have little or no cytotoxic action of their own, but inhibit (P-gp) or MRP-mediated drug export and are capable of sensitizing MDR cells to the cytotoxic effects of chemotherapeutic drugs. Here we examined the ability of steroidal alkaloids of plant origin, namely the Veratrum sp. alkaloid cyclopamine and the Lycopersicon sp. alkaloid tomatidine, to act as potent and effective chemosensitizers in multidrug resistant tumor cells. Drug uptake was determined by measuring accumulation of tetramethylrosamine in multidrug resistant NCI AdrR human adenocarcinoma cells. Resistance to adriamycin and vinblastine was determined by utilizing the MTT cell survival assay. Cyclopamine and tomatidine elevate tetramethylrosamine uptake by NCI AdrR cells and sensitize the cells to the cytotoxic action of adriamycin and vinblastine. In both cases these agents are comparable in patency and efficacy to verapamil, a reversal agent commonly used in MDR research. It is concluded that steroidal alkaloids of plant origin act as inhibitors of P-gp-mediated drug transport and multidrug resistance and therefore may serve as chemosensitizers in combination chemotherapy with conventional cytotoxic drugs for treating multidrug resistant cancer.

  4. Demographic effects of deltamethrin resistance in the Chagas disease vector Triatoma infestans.

    PubMed

    Germano, M D; Picollo, M I

    2016-12-01

    Triatoma infestans (Heteroptera: Reduviidae) Klug is the main vector of Chagas disease in Latin America. Resistance to deltamethrin was reported in Argentina and recently associated with reproductive and longevity trade-offs. The objectives of the present study were to describe the demographic consequences of deltamethrin resistance in T. infestans and to establish possible target stages for chemical control in susceptible and resistant colonies. A stage-classified matrix model was constructed based on the average stage length for susceptible, resistant and reciprocal matings' progeny. The differences between colonies were analysed by prospective and retrospective analysis. The life table parameters indicated reduced fecundity, fertility and population growth in resistant insects. The retrospective analysis suggested the latter was associated with lower reproductive output and increased fifth-instar nymph stage length. The prospective analysis suggested that the adult stage should be the main target for insecticide control. Although, fifth-instar nymphs should also be targeted when resistance has been detected. The presented results show demographic effects of deltamethrin resistance in T. infestans. While the older stages could be the main targets for chemical control, this approach is impeded by their higher tolerance to insecticides. It is concluded that the different mode of action insecticides would be more effective than a dose increase for the control of deltamethrin-resistant T. infestans.

  5. Symmetric Kullback-Leibler Metric Based Tracking Behaviors for Bioinspired Robotic Eyes

    PubMed Central

    Liu, Hengli; Luo, Jun; Wu, Peng; Xie, Shaorong; Li, Hengyu

    2015-01-01

    A symmetric Kullback-Leibler metric based tracking system, capable of tracking moving targets, is presented for a bionic spherical parallel mechanism to minimize a tracking error function to simulate smooth pursuit of human eyes. More specifically, we propose a real-time moving target tracking algorithm which utilizes spatial histograms taking into account symmetric Kullback-Leibler metric. In the proposed algorithm, the key spatial histograms are extracted and taken into particle filtering framework. Once the target is identified, an image-based control scheme is implemented to drive bionic spherical parallel mechanism such that the identified target is to be tracked at the center of the captured images. Meanwhile, the robot motion information is fed forward to develop an adaptive smooth tracking controller inspired by the Vestibuloocular Reflex mechanism. The proposed tracking system is designed to make the robot track dynamic objects when the robot travels through transmittable terrains, especially bumpy environment. To perform bumpy-resist capability under the condition of violent attitude variation when the robot works in the bumpy environment mentioned, experimental results demonstrate the effectiveness and robustness of our bioinspired tracking system using bionic spherical parallel mechanism inspired by head-eye coordination. PMID:27019592

  6. Symmetric Kullback-Leibler Metric Based Tracking Behaviors for Bioinspired Robotic Eyes.

    PubMed

    Liu, Hengli; Luo, Jun; Wu, Peng; Xie, Shaorong; Li, Hengyu

    2015-01-01

    A symmetric Kullback-Leibler metric based tracking system, capable of tracking moving targets, is presented for a bionic spherical parallel mechanism to minimize a tracking error function to simulate smooth pursuit of human eyes. More specifically, we propose a real-time moving target tracking algorithm which utilizes spatial histograms taking into account symmetric Kullback-Leibler metric. In the proposed algorithm, the key spatial histograms are extracted and taken into particle filtering framework. Once the target is identified, an image-based control scheme is implemented to drive bionic spherical parallel mechanism such that the identified target is to be tracked at the center of the captured images. Meanwhile, the robot motion information is fed forward to develop an adaptive smooth tracking controller inspired by the Vestibuloocular Reflex mechanism. The proposed tracking system is designed to make the robot track dynamic objects when the robot travels through transmittable terrains, especially bumpy environment. To perform bumpy-resist capability under the condition of violent attitude variation when the robot works in the bumpy environment mentioned, experimental results demonstrate the effectiveness and robustness of our bioinspired tracking system using bionic spherical parallel mechanism inspired by head-eye coordination.

  7. Short-Term Effects of Different Loading Schemes in Fitness-Related Resistance Training.

    PubMed

    Eifler, Christoph

    2016-07-01

    Eifler, C. Short-term effects of different loading schemes in fitness-related resistance training. J Strength Cond Res 30(7): 1880-1889, 2016-The purpose of this investigation was to analyze the short-term effects of different loading schemes in fitness-related resistance training and to identify the most effective loading method for advanced recreational athletes. The investigation was designed as a longitudinal field-test study. Two hundred healthy mature subjects with at least 12 months' experience in resistance training were randomized in 4 samples of 50 subjects each. Gender distribution was homogenous in all samples. Training effects were quantified by 10 repetition maximum (10RM) and 1 repetition maximum (1RM) testing (pre-post-test design). Over a period of 6 weeks, a standardized resistance training protocol with 3 training sessions per week was realized. Testing and training included 8 resistance training exercises in a standardized order. The following loading schemes were randomly matched to each sample: constant load (CL) with constant volume of repetitions, increasing load (IL) with decreasing volume of repetitions, decreasing load (DL) with increasing volume of repetitions, daily changing load (DCL), and volume of repetitions. For all loading schemes, significant strength gains (p < 0.001) could be noted for all resistance training exercises and both dependent variables (10RM, 1RM). In all cases, DCL obtained significantly higher strength gains (p < 0.001) than CL, IL, and DL. There were no significant differences in strength gains between CL, IL, and DL. The present data indicate that resistance training following DCL is more effective for advanced recreational athletes than CL, IL, or DL. Considering that DCL is widely unknown in fitness-related resistance training, the present data indicate, there is potential for improving resistance training in commercial fitness clubs.

  8. Partial rectangular metric spaces and fixed point theorems.

    PubMed

    Shukla, Satish

    2014-01-01

    The purpose of this paper is to introduce the concept of partial rectangular metric spaces as a generalization of rectangular metric and partial metric spaces. Some properties of partial rectangular metric spaces and some fixed point results for quasitype contraction in partial rectangular metric spaces are proved. Some examples are given to illustrate the observed results.

  9. Advanced metrics for network-centric naval operations

    NASA Astrophysics Data System (ADS)

    Perry, Walter L.; Bowden, Fred D. J.

    2003-07-01

    Defense organizations around the world are formulating new visions, strategies, and concepts that utilize emerging information-age technologies. Central among these is network-based operations. Measures and metrics are needed that allow analysts to link the effects of alternative network structures, operating procedures and command and control arrangements to combat outcomes. This paper reports on measures and mathematical metrics that begin to address this problem. Networks are assessed in terms of their complexity, their ability to adapt, and the collaboration opportunity they afford. The metrics measure the contributions of complexity to information flow, and the deleterious effects of information overload and disconfirming reports to overall network performance. In addition, they measure the contributions of collaboration to shared situational awareness in terms of the accuracy and precision of the information produced and the costs associated with an imbalance of the two. We posit a fixed network connecting a Naval Task Force"s various platforms, and assess the ability of this network to support the range of missions required of the task force. The emphasis is not on connectivity, but rather on information flow and how well the network is able to adapt to alternative flow requirements. We assess the impact alternative network structures, operating procedures and command arrangements have on combat outcomes by applying the metrics to a cruise missile defense scenario.

  10. Experimental and numerical study of the effective thermal conductivity of silica nanocomposites with thermal boundary resistance

    SciTech Connect

    Kothari, Rushabh M; Dinwiddie, Ralph Barton; Wang, Hsin

    2013-01-01

    The thermal interface resistance at the macro scale is mainly described by the physical gap between two interfaces and constriction resistance due to this gap. The small gaps between the two material faces makes up the majority of thermal interface resistance at the macro scale. So, most of the studies have been focused on characterizing effect of surface geometry and material properties to thermal interface resistance. This resistance is more widely known as thermal contact resistance, represented with Rc. There are various models to predict thermal contact resistance at macro scale. These models predict thermal resistance Rc for given two materials by utilizing their bulk thermomechanical properties. Although, Rc represents thermal resistance accurately for macro size contacts between two metals, it is not suitable to describe interface resistance of particles in modern TIMs, aka particulate composites. The particles inside recently available TIMs are micron size and with effort to further increase surface area this particle size is approaching nano scale. At this small scale, Rc does not accurately predict thermal interface, as it is very difficult to characterize the surface topography. The thermal discontinuity at perfectly bonded interface of two dissimilar materials is termed as thermal boundary resistance (Rb) or Kapitza resistance. The macroscopic assumptions that thermal discontinuity only exists due to gaps and surface geometry leads to substantial error in determining interface thermal properties at micron and nano scale. The phenomenon of thermal boundary resistance is an inherent material property and arises due to fundamental mechanism of thermal transport. For metal-matrix particulate composites, Rb plays more important role than Rc. The free flowing nature of the polymer would eliminate most of the gaps between the two materials at their interface. This means almost all of the thermal resistance at particle/matrix interface would occur due to Rb

  11. Set Configuration in Resistance Exercise: Muscle Fatigue and Cardiovascular Effects

    PubMed Central

    Río-Rodríguez, Dan; Iglesias-Soler, Eliseo; Fernández del Olmo, Miguel

    2016-01-01

    Purpose Cardiovascular responses of traditional resistance (TS) training have been extensively explored. However, the fatigue mechanisms associated with an intra-set rest configuration (ISR) have not been investigated. This study compares two modalities of set configurations for resistance exercise that equates work to rest ratios and measures the central and peripheral fatigue in combination with cortical, hemodynamic and cardiovascular measures. Methods 11 subjects performed two isometric knee extension training sessions using TS and ISR configurations. Voluntary activation (VA), single twitch amplitude, low frequency fatigue (LFF), Mwave, motor evoked potential (MEP), short intracortical inhibition (SICI), intracortical facilitation (ICF) and heart rate variability were evaluated before and after each training session. During each session beat to beat heart rate, blood pressure and rate pressure product (RPP) were also evaluated. Results After exercise VA decreased significantly for TS but not for ISR (P < 0.001), single twitch amplitude and LFF values were lower for TS than ISR (P < 0.004), and SICI was reduced only for the TS configuration (P = 0.049). During exercise RPP values were significantly higher for the TS than for ISR (P = 0.001). RPP correlated with VA for TS (r = -.85 P < 0.001) suggesting a relationship between central fatigue and cardiovascular stress. Conclusions We conclude that ISR induced lower central and peripheral fatigue as well as lower cardiovascular stress in comparison with TS configuration. Our study suggests that set configuration is a key factor in the regulation of the neuromuscular and cardiovascular responses of resistance training. PMID:26982500

  12. Extrapolating the Acute Behavioral Effects of Toluene from 1-Hour to 24-Hour Exposures in Rats: Roles of Dose Metric, and Metabolic and Behavioral Tolerance.

    EPA Science Inventory

    Recent research on the acute effects of volatile organic compounds (VQCs) suggests that extrapolation from short (~ 1 h) to long durations (up to 4 h) may be improved by using estimates of brain toluene concentration (Br[Tol]) instead of cumulative inhaled dose (C x t) as a metri...

  13. Plant resistance reduces the strength of consumptive and non-consumptive effects of predators on aphids.

    PubMed

    Kersch-Becker, Mônica F; Thaler, Jennifer S

    2015-09-01

    1. The impact of predators on prey has traditionally been attributed to the act of consumption. Prey responses to the presence of the predator (non-consumptive effects), however, can be as important as predation itself. While plant defences are known to influence predator-prey interactions, their relative effects on consumptive vs. non-consumptive effects are not well understood. 2. We evaluated the consequences of plant resistance and predators (Hippodamia convergens) on the mass, number of nymphs, population growth, density and dispersal of aphids (Macrosiphum euphorbiae). We tested for the effects of plant resistance on non-consumptive and consumptive effects of predators on aphid performance and dispersal using a combination of path analysis and experimental manipulation of predation risk. 3. We manipulated plant resistance using genetically modified lines of tomato (Solanum lycopersicum) that vary incrementally in the expression of the jasmonate pathway, which mediates induced resistance to insects and manipulated aphid exposure to lethal and risk predators. Predation risk predators had mandibles impaired to prevent killing. 4. Plant resistance reduced predation rate (consumptive effect) on high resistance plants. As a consequence, predators had no impact on the number of nymphs, aphid density or population growth on high resistance plants, whereas on low resistance plants, predators reduced aphid density by 35% and population growth by 86%. Path analysis and direct manipulation of predation risk showed that predation risk rather than predation rate promoted aphid dispersal and varied with host plant resistance. Aphid dispersal in response to predation risk was greater on low compared to high resistance plants. The predation risk experiment also showed that the number of aphid nymphs increased in the presence of risk predators but did not translate into increased population growth. 5. In conclusion, the consumptive and non-consumptive components of predators

  14. Effect of chlorfenapyr on cypermethrin-resistant Culex pipiens pallens Coq mosquitoes.

    PubMed

    Yuan, J Z; Li, Q F; Huang, J B; Gao, J F

    2015-03-01

    Chlorfenapyr is a promising pyrrole insecticide with a unique mechanism of action that does not confer cross-resistance to neurotoxic insecticides. The effect of chlorfenapyr on pyrethorid-resistant Culex pipiens pallens Coq (Diptera: Culicidae) has not been fully investigated under laboratory conditions. In this study, cypermethrin-resistant C. p. pallens exhibited 376.79-fold and 395.40-fold increase in resistance to cypermethrin compared with susceptible strains after exposure for 24 and 48h, respectively. Larvae and adults were tested for susceptibility using dipping, topical, and impregnated paper methods as recommended by the WHO. No cross-resistance to chlorfenapyr was found. Increased mortality was apparent between 48 and 72h, indicating a slow rate of toxic activity. Synergism experiments with piperonyl butoxide (PBO) showed an antagonistic effect on chlorfenapyr toxicity. Mixtures of chlorfenapyr and cypermethrin could therefore provide additional benefits over either insecticide used alone. Mixtures of 5ng/ml chlorfenapyr and 500ng/ml cypermethrin exhibited a slight synergistic effect on cypermethrin-resistant mosquitoes (3.33, 6.84 and 2.34% after 24, 48 and 72h exposure, respectively. This activity was lost when the chlorfenapyr concentration was increased to 10 or 20ng/ml. Chlorfenapyr showed quite good results for pyrethroid-resistant C. p. pallens, and could improve public health by reducing the occurrence of mosquito bites and subsequently protecting against transmission of lymphatic filariasis and Japanese encephalitis.

  15. An analytical solution for contact resistance of staggered organic field-effect transistors

    NASA Astrophysics Data System (ADS)

    Karimi-Alavijeh, Hamidreza; Katebi-Jahromi, Alireza

    2017-03-01

    We have developed analytical models for bias dependent contact resistance (RC) and output characteristics of staggered organic field-effect transistors (OFETS) based on a bulk resistance-approximated and mobility-modified current-crowding method. Numerical evaluations of RC and its resistive components show that the bias dependency of the bulk resistance is negligible. Consequently, the properties of the active layer interfaces determine RC and its characteristics. Effective parameters include a normally constant charge injection barrier at the organic-metal interface (Eb) and a gate induced surface carrier-concentration (PS0) at the organic-insulator boundary. The energy barrier pertains to the fabrication process, and its related resistance (rc) can be determined as the fitting parameter of the theoretical model. However, PS0 is strongly gate bias dependent and the results of the numerical model indicate that the resulting component (rch) is dominant and has a considerable effect on RC and its characteristics. More importantly, PS0 as the key parameter of the contact resistance is analytically expressible and by using a proposed mobility-modified current-crowding model, the contact resistance can be analytically formulated. Accordingly, the output characteristics of the OFETs in the triode region can be also analytically modeled using the developed relation of RC.

  16. The effect of surface roughness on the resistivity increase in nanometric dimensions

    NASA Astrophysics Data System (ADS)

    Marom, H.; Eizenberg, M.

    2006-06-01

    Materials with nanometric dimensions exhibit higher electrical resistivity due to additional scattering centers for the conduction electrons, mainly from surfaces and grain boundaries. In this study we focus on the effect of surfaces by implementing an experimental technique in which the resistivity of thin films is measured during and after etching them inside a solution. This technique enables to analyze the contribution of surfaces to the resistivity and gives a unique insight as for the effect of surface roughness. It is shown that the scattering of electrons from annealed copper films with smooth enough surfaces is mostly specular and that the resistivity in this case is dominated by the effect of grain boundaries. However, when the roughness of the surface becomes larger than the de Broglie wavelength of the electrons, a substantial increase in resistivity occurs. This roughness-induced resistivity is analyzed and shown to be much larger in certain cases than the resistivity predicted for a flat surface, even when all electron scatterings are assumed to be completely diffused.

  17. Effect of MTA and Portland Cement on Fracture Resistance of Dentin.

    PubMed

    Forghani, Maryam; Bidar, Maryam; Shahrami, Fatemeh; Bagheri, Mahmoud; Mohammadi, Maryam; Attaran Mashhadi, Niloufar

    2013-01-01

    Background and aims. It is important to evaluate the effects of endodontic materials on tooth structures to avoid endodontic treatment failure. The aim of the present study was to investigate the effect of mineral trioxide aggregates (MTA) and Portland cement (PC) on fracture resistance of dentin. Materials and methods. Thirty-six freshly extracted human single-rooted premolar teeth were selected. The crowns were removed and the roots were randomly divided into two experimental groups and one control group. The root samples were longitudinally divided into two halves and a dentin bar (2×2×10 mm) was cut from each root section for short-term (2weeks) and long-term (12 weeks) evaluations. The root sections in the experimental groups were exposed to MTA or PC, while keeping the control group specimens in physiologic saline. The fracture resistance of each specimen was measured using an Instron testing machine. The results were statistically analyzed using ANOVA, a post hoc Tukey test and paired t-test at 5% significance level. Results. The fracture resistance of MTA-treated specimens significantly increased between 2 and 12 weeks (P<0.05). After 12 weeks, MTA-treated specimens had the highest fracture resistance. In the PC group, the fracture resistance of specimens did not change significantly over time (P>0.05). Conclusion. The results showed that MTA increased the fracture resistance of root dentin, while PC had no significant effect on dentin fracture resistance.

  18. Magnetically induced nonvolatile magnetoresistance and resistance memory effect in phase-separated manganite thin films

    NASA Astrophysics Data System (ADS)

    Li, Qian; Cao, Qingqi; Wang, Dunhui; Du, Youwei

    2017-03-01

    We report the observation of magnetically induced resistance memory effect in a typical electronic phase-separated manganite La5/8‑x Pr x Ca3/8MnO3 (x  =  0.3) thin film. In the hysteresis region of metal-to-insulator transition, the resistance exhibits a sharp drop with the application of magnetic field and maintains the low resistance state after the removal of field, showing a nonvolatile magnetoresistance effect. The high resistance state can be recovered until the temperature is warmed. More explicit measurements at the hysteresis region exhibit the non-volatility and irreversibility of magnetoresistance, which can be ascribed to the percolative feature in the electronic phase-separated manganite. The origin and potential applications of these interesting effects are discussed.

  19. Effect of internal resistance of a Helmholtz resonator on acoustic energy reduction in enclosures.

    PubMed

    Yu, Ganghua; Li, Deyu; Cheng, Li

    2008-12-01

    The effect of internal resistance of a Helmholtz resonator on acoustic energy reduction in an enclosure and the multimodal coupling-based Helmholtz resonator design are investigated. Using the analytical solution of a resonator-enclosure interaction model, an energy reduction index is defined in a frequency band to optimize the resonator resistance. The dual process of energy dissipation and radiation of the resonator is quantified. Optimal resistance of the resonator and its physical effect on the resonator-enclosure interaction are numerically evaluated and categorized in terms of frequency bandwidths. Predictions on the resonator performance are confirmed by experiments. Comparisons with existing models based on different optimization criteria are also performed. It is shown that the proposed model serves as an effective design tool to determine the internal resistance of the resonator in order to achieve sound reduction in the frequency band enclosing acoustic resonances.

  20. Multidisciplinary life cycle metrics and tools for green buildings.

    PubMed

    Helgeson, Jennifer F; Lippiatt, Barbara C

    2009-07-01

    Building sector stakeholders need compelling metrics, tools, data, and case studies to support major investments in sustainable technologies. Proponents of green building widely claim that buildings integrating sustainable technologies are cost effective, but often these claims are based on incomplete, anecdotal evidence that is difficult to reproduce and defend. The claims suffer from 2 main weaknesses: 1) buildings on which claims are based are not necessarily "green" in a science-based, life cycle assessment (LCA) sense and 2) measures of cost effectiveness often are not based on standard methods for measuring economic worth. Yet, the building industry demands compelling metrics to justify sustainable building designs. The problem is hard to solve because, until now, neither methods nor robust data supporting defensible business cases were available. The US National Institute of Standards and Technology (NIST) Building and Fire Research Laboratory is beginning to address these needs by developing metrics and tools for assessing the life cycle economic and environmental performance of buildings. Economic performance is measured with the use of standard life cycle costing methods. Environmental performance is measured by LCA methods that assess the "carbon footprint" of buildings, as well as 11 other sustainability metrics, including fossil fuel depletion, smog formation, water use, habitat alteration, indoor air quality, and effects on human health. Carbon efficiency ratios and other eco-efficiency metrics are established to yield science-based measures of the relative worth, or "business cases," for green buildings. Here, the approach is illustrated through a realistic building case study focused on different heating, ventilation, air conditioning technology energy efficiency. Additionally, the evolution of the Building for Environmental and Economic Sustainability multidisciplinary team and future plans in this area are described.

  1. Altmetrics - a complement to conventional metrics.

    PubMed

    Melero, Remedios

    2015-01-01

    Emerging metrics based on article-level does not exclude traditional metrics based on citations to the journal, but complements them. Both can be employed in conjunction to offer a richer picture of an article use from immediate to long terms. Article-level metrics (ALM) is the result of the aggregation of different data sources and the collection of content from multiple social network services. Sources used for the aggregation can be broken down into five categories: usage, captures, mentions, social media and citations. Data sources depend on the tool, but they include classic metrics indicators based on citations, academic social networks (Mendeley, CiteULike, Delicious) and social media (Facebook, Twitter, blogs, or Youtube, among others). Altmetrics is not synonymous with alternative metrics. Altmetrics are normally early available and allow to assess the social impact of scholarly outputs, almost at the real time. This paper overviews briefly the meaning of altmetrics and describes some of the existing tools used to apply this new metrics: Public Library of Science--Article-Level Metrics, Altmetric, Impactstory and Plum.

  2. Fighter agility metrics. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Liefer, Randall K.

    1990-01-01

    Fighter flying qualities and combat capabilities are currently measured and compared in terms relating to vehicle energy, angular rates and sustained acceleration. Criteria based on these measurable quantities have evolved over the past several decades and are routinely used to design aircraft structures, aerodynamics, propulsion and control systems. While these criteria, or metrics, have the advantage of being well understood, easily verified and repeatable during test, they tend to measure the steady state capability of the aircraft and not its ability to transition quickly from one state to another. Proposed new metrics to assess fighter aircraft agility are collected and analyzed. A framework for classification of these new agility metrics is developed and applied. A complete set of transient agility metrics is evaluated with a high fidelity, nonlinear F-18 simulation. Test techniques and data reduction methods are proposed. A method of providing cuing information to the pilot during flight test is discussed. The sensitivity of longitudinal and lateral agility metrics to deviations from the pilot cues is studied in detail. The metrics are shown to be largely insensitive to reasonable deviations from the nominal test pilot commands. Instrumentation required to quantify agility via flight test is also considered. With one exception, each of the proposed new metrics may be measured with instrumentation currently available.

  3. Launch Vehicle Production and Operations Cost Metrics

    NASA Technical Reports Server (NTRS)

    Watson, Michael D.; Neeley, James R.; Blackburn, Ruby F.

    2014-01-01

    Traditionally, launch vehicle cost has been evaluated based on $/Kg to orbit. This metric is calculated based on assumptions not typically met by a specific mission. These assumptions include the specified orbit whether Low Earth Orbit (LEO), Geostationary Earth Orbit (GEO), or both. The metric also assumes the payload utilizes the full lift mass of the launch vehicle, which is rarely true even with secondary payloads.1,2,3 Other approaches for cost metrics have been evaluated including unit cost of the launch vehicle and an approach to consider the full program production and operations costs.4 Unit cost considers the variable cost of the vehicle and the definition of variable costs are discussed. The full program production and operation costs include both the variable costs and the manufacturing base. This metric also distinguishes operations costs from production costs, including pre-flight operational testing. Operations costs also consider the costs of flight operations, including control center operation and maintenance. Each of these 3 cost metrics show different sensitivities to various aspects of launch vehicle cost drivers. The comparison of these metrics provides the strengths and weaknesses of each yielding an assessment useful for cost metric selection for launch vehicle programs.

  4. Advanced Life Support System Value Metric

    NASA Technical Reports Server (NTRS)

    Jones, Harry W.; Arnold, James O. (Technical Monitor)

    1999-01-01

    The NASA Advanced Life Support (ALS) Program is required to provide a performance metric to measure its progress in system development. Extensive discussions within the ALS program have reached a consensus. The Equivalent System Mass (ESM) metric has been traditionally used and provides a good summary of the weight, size, and power cost factors of space life support equipment. But ESM assumes that all the systems being traded off exactly meet a fixed performance requirement, so that the value and benefit (readiness, performance, safety, etc.) of all the different systems designs are exactly equal. This is too simplistic. Actual system design concepts are selected using many cost and benefit factors and the system specification is then set accordingly. The ALS program needs a multi-parameter metric including both the ESM and a System Value Metric (SVM). The SVM would include safety, maintainability, reliability, performance, use of cross cutting technology, and commercialization potential. Another major factor in system selection is technology readiness level (TRL), a familiar metric in ALS. The overall ALS system metric that is suggested is a benefit/cost ratio, [SVM + TRL]/ESM, with appropriate weighting and scaling. The total value is the sum of SVM and TRL. Cost is represented by ESM. The paper provides a detailed description and example application of the suggested System Value Metric.

  5. Altmetrics – a complement to conventional metrics

    PubMed Central

    Melero, Remedios

    2015-01-01

    Emerging metrics based on article-level does not exclude traditional metrics based on citations to the journal, but complements them. Both can be employed in conjunction to offer a richer picture of an article use from immediate to long terms. Article-level metrics (ALM) is the result of the aggregation of different data sources and the collection of content from multiple social network services. Sources used for the aggregation can be broken down into five categories: usage, captures, mentions, social media and citations. Data sources depend on the tool, but they include classic metrics indicators based on citations, academic social networks (Mendeley, CiteULike, Delicious) and social media (Facebook, Twitter, blogs, or Youtube, among others). Altmetrics is not synonymous with alternative metrics. Altmetrics are normally early available and allow to assess the social impact of scholarly outputs, almost at the real time. This paper overviews briefly the meaning of altmetrics and describes some of the existing tools used to apply this new metrics: Public Library of Science - Article-Level Metrics, Altmetric, Impactstory and Plum. PMID:26110028

  6. SAPHIRE 8 Quality Assurance Software Metrics Report

    SciTech Connect

    Kurt G. Vedros

    2011-08-01

    The purpose of this review of software metrics is to examine the quality of the metrics gathered in the 2010 IV&V and to set an outline for results of updated metrics runs to be performed. We find from the review that the maintenance of accepted quality standards presented in the SAPHIRE 8 initial Independent Verification and Validation (IV&V) of April, 2010 is most easily achieved by continuing to utilize the tools used in that effort while adding a metric of bug tracking and resolution. Recommendations from the final IV&V were to continue periodic measurable metrics such as McCabe's complexity measure to ensure quality is maintained. The four software tools used to measure quality in the IV&V were CodeHealer, Coverage Validator, Memory Validator, Performance Validator, and Thread Validator. These are evaluated based on their capabilities. We attempted to run their latest revisions with the newer Delphi 2010 based SAPHIRE 8 code that has been developed and was successful with all of the Validator series of tools on small tests. Another recommendation from the IV&V was to incorporate a bug tracking and resolution metric. To improve our capability of producing this metric, we integrated our current web reporting system with the SpiraTest test management software purchased earlier this year to track requirements traceability.

  7. Resistance training among young athletes: safety, efficacy and injury prevention effects.

    PubMed

    Faigenbaum, A D; Myer, G D

    2010-01-01

    A literature review was employed to evaluate the current epidemiology of injury related to the safety and efficacy of youth resistance training. Several case study reports and retrospective questionnaires regarding resistance exercise and the competitive sports of weightlifting and powerlifting reveal that injuries have occurred in young lifters, although a majority can be classified as accidental. Lack of qualified instruction that underlies poor exercise technique and inappropriate training loads could explain, at least partly, some of the reported injuries. Current research indicates that resistance training can be a safe, effective and worthwhile activity for children and adolescents provided that qualified professionals supervise all training sessions and provide age-appropriate instruction on proper lifting procedures and safe training guidelines. Regular participation in a multifaceted resistance training programme that begins during the preseason and includes instruction on movement biomechanics may reduce the risk of sports-related injuries in young athletes. Strategies for enhancing the safety of youth resistance training are discussed.

  8. Spectral analysis of turbulent effects on resistivity and the tearing instability. [of plasmas

    NASA Technical Reports Server (NTRS)

    Deeds, D.; Van Hoven, G.

    1988-01-01

    A spectral numerical-simulation code and ancillary diagnostics are used here to analyze the behavior of resistive magnetic tearing in the presence of short-wavelength turbulence. It is found that, in general, the anomalous resistivity defined by Biskamp and Welter (1983) due to short-wavelength turbulence tends to return quickly towards zero even when artificially supported away from zero, and that its effect on tearing-mode behavior is not consistent with its interpretation as a resistivity. The behavior reported by Biskamp and Welter and the behavior observed here are analyzed. It is argued that, while not meaningful as a true resistivity, the anomalous resistivity parameter is a useful diagnostic showing the energy balance of the system.

  9. Effects of glucocorticoids in potentiating diuresis in heart failure patients with diuretic resistance.

    PubMed

    Liu, Chao; Liu, Kunshen

    2014-09-01

    Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting decongestion and improvement in renal function in patients with heart failure have failed to show benefit in randomized clinical trials. Glucocorticoids had been used to manage diuretic resistance before the advent of loop diuretics. More recent evidence appears to confirm that glucocorticoids may also help to overcome resistance to loop diuretics. This review tries to summarize the available evidence and potential mechanisms related to glucocorticoid therapy in patients with heart failure and its effect on diuretic resistance.

  10. Substitution for chromium in 304 stainless steel. [effects on oxidation and corrosion resistance

    NASA Technical Reports Server (NTRS)

    Stephens, J. R.; Barrett, C. A.

    1978-01-01

    An investigation was conducted to determine the effects of substituting less strategic elements for Cr on oxidation and corrosion resistance of AISI 304 stainless steel. Cyclic oxidation resistance was evaluated at 870 C. Corrosion resistance was determined by exposure of specimens to a boiling copper-rich solution of copper sulfate and sulfuric acid. Alloy substitutes for Cr included Al, Mn, Mo, Si, Ti, V, Y, and misch metal. A level of about 12% Cr was the minimum amount of Cr required for adequate oxidation and corrosion resistance in the modified composition 304 stainless steels. This represents a Cr saving of 33 percent. Two alloys containing 12% Cr plus 2% Al plus 2% Mo and 12% Cr plus 2.65% Si were identified which exhibited oxidation and corrosion resistance comparable to AISI 304 stainless steel.

  11. The effect of polymer matrix on laser microfabrication of Au nanoparticles dispersed polymer resists

    NASA Astrophysics Data System (ADS)

    Yagyu, Hiromasa; Tabata, Osamu

    2008-12-01

    The effect of polymer matrix on laser processing of Au nanoparticles dispersed polymer resist was reported. Au nanoparticles dispersed polymer is a resist in which Au nanoparticles with average diameter of around 3 nm was dispersed. Since the resist has a strong absorption at the wavelength of around 530 nm, it can be micromachined using focused low power Nd:YVO 4-SHG laser (CW, wavelength of 532 nm). From the evaluation of a dispersibility of Au nanoparticle in the different polymer using X-ray diffraction and visible ray absorbance, it was confirmed that the dispersibility of Au nanoparticle induced by the kind of polymer matrix influenced laser-processed shape. Moreover, from thermal properties and the calculation of temperature rise distribution by laser beam in polymer resist, it was predicted that the processing mechanism for thermoplastic polymer resist was related with melt and grain growth of Au nanoparticle.

  12. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance.

    PubMed

    Rawson, Eric S; Volek, Jeff S

    2003-11-01

    Creatine monohydrate has become the supplement of choice for many athletes striving to improve sports performance. Recent data indicate that athletes may not be using creatine as a sports performance booster per se but instead use creatine chronically as a training aid to augment intense resistance training workouts. Although several studies have evaluated the combined effects of creatine supplementation and resistance training on muscle strength and weightlifting performance, these data have not been analyzed collectively. The purpose of this review is to evaluate the effects of creatine supplementation on muscle strength and weightlifting performance when ingested concomitant with resistance training. The effects of gender, interindividual variability, training status, and possible mechanisms of action are discussed. Of the 22 studies reviewed, the average increase in muscle strength (1, 3, or 10 repetition maximum [RM]) following creatine supplementation plus resistance training was 8% greater than the average increase in muscle strength following placebo ingestion during resistance training (20 vs. 12%). Similarly, the average increase in weightlifting performance (maximal repetitions at a given percent of maximal strength) following creatine supplementation plus resistance training was 14% greater than the average increase in weightlifting performance following placebo ingestion during resistance training (26 vs. 12%). The increase in bench press 1RM ranged from 3 to 45%, and the improvement in weightlifting performance in the bench press ranged from 16 to 43%. Thus there is substantial evidence to indicate that creatine supplementation during resistance training is more effective at increasing muscle strength and weightlifting performance than resistance training alone, although the response is highly variable.

  13. Safety and effectiveness of home intravenous antibiotic therapy for multidrug-resistant bacterial infections.

    PubMed

    Mujal, A; Sola, J; Hernandez, M; Villarino, M-A; Machado, M-L; Baylina, M; Tajan, J; Oristrell, J

    2015-06-01

    Home intravenous antibiotic therapy is an alternative to hospital admission for moderately severe infections. However, few studies have analyzed its safety and effectiveness in the treatment of infections caused by multidrug-resistant bacteria. The purpose of this study is to analyze the safety and effectiveness of home intravenous antibiotic therapy in multidrug-resistant bacterial infections. We analyzed prospectively all patients admitted to our service who underwent home intravenous antibiotic therapy during the period 2008-2012. All the treatments were administered by caretakers or self-administered by patients, through elastomeric infusion devices. Effectiveness was evaluated by analyzing the readmission rate for poor infection control. Safety was evaluated by analyzing adverse events, catheter-related complications, and readmissions not related to poor infection control. There were 433 admissions (in 355 patients) for home intravenous antibiotic therapy during the study period. There were 226 (52.2 %) admissions due to multidrug-resistant bacterial infections and 207 (47.8 %) due to non-multidrug-resistant infections. Hospital readmissions in patients with multidrug-resistant infections were uncommon. Multidrug-resistant enterococcal infections, healthcare-associated infections, and carbapenem therapy were independent variables associated with increased readmissions due to poor infection control. Readmissions not related to poor infection control, adverse events, and catheter-related complications were similar in multidrug-resistant compared to non-multidrug-resistant bacterial infections. Home intravenous therapy, administered by patients or their caretakers using elastomeric infusion pumps, was safe and effective for the treatment of most multidrug-resistant bacterial infections.

  14. Effect of microstructure on air oxidation resistance of nuclear graphite

    SciTech Connect

    Contescu, Cristian I; Guldan, Tyler R; Wang, Peng; Burchell, Timothy D

    2012-01-01

    Oxidation resistance in air of three grades of nuclear graphite with different structures was compared using a standard thermogravimetric method. Differences in the oxidation behavior have been identified with respect to both (i) the rate of oxidation in identical conditions and the derived apparent activation energy and pre-exponential factor and (ii) the penetration depth of the oxidant and the development of the oxidized layer. These differences were ascribed to structural differences between the three graphite grades, in particular the grain size and shape of the graphite filler, and the associated textural properties, such as total BET surface area and porosity distribution in the un-oxidized material. It was also found that the amount of strongly bonded surface oxygen complexes measured by thermodesorption significantly exceeds the amount afforded by the low BET surface area, and therefore low temperature oxygen chemisorption is not a reliable method for determining the amount of surface sites (re)active during air oxidation. The relationship between nuclear graphite microstructure and its oxidation resistance demonstrated in this work underlines the importance of performing comprehensive oxidation characterization studies of the new grades of nuclear graphite considered as candidates for very high temperature gas-cooled reactors.

  15. Effects of mefloquine use on Plasmodium vivax multidrug resistance.

    PubMed

    Khim, Nimol; Andrianaranjaka, Voahangy; Popovici, Jean; Kim, Saorin; Ratsimbasoa, Arsene; Benedet, Christophe; Barnadas, Celine; Durand, Remy; Thellier, Marc; Legrand, Eric; Musset, Lise; Menegon, Michela; Severini, Carlo; Nour, Bakri Y M; Tichit, Magali; Bouchier, Christiane; Mercereau-Puijalon, Odile; Ménard, Didier

    2014-10-01

    Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infection triggered by P. falciparum infections expose non-P. falciparum parasites to mefloquine. To assess the consequences of such unintentional treatments on P. vivax, we studied variations in number of Pvmdr-1 (PlasmoDB accession no. PVX_080100, NCBI reference sequence NC_009915.1) copies worldwide in 607 samples collected in areas with different histories of mefloquine use from residents and from travelers returning to France. Number of Pvmdr-1 copies correlated with drug use history. Treatment against P. falciparum exerts substantial collateral pressure against sympatric P. vivax, jeopardizing future use of mefloquine against P. vivax. A drug policy is needed that takes into consideration all co-endemic species of malaria parasites.

  16. Revision and extension of Eco-LCA metrics for sustainability assessment of the energy and chemical processes.

    PubMed

    Yang, Shiying; Yang, Siyu; Kraslawski, Andrzej; Qian, Yu

    2013-12-17

    Ecologically based life cycle assessment (Eco-LCA) is an appealing approach for the evaluation of resources utilization and environmental impacts of the process industries from an ecological scale. However, the aggregated metrics of Eco-LCA suffer from some drawbacks: the environmental impact metric has limited applicability; the resource utilization metric ignores indirect consumption; the renewability metric fails to address the quantitative distinction of resources availability; the productivity metric seems self-contradictory. In this paper, the existing Eco-LCA metrics are revised and extended for sustainability assessment of the energy and chemical processes. A new Eco-LCA metrics system is proposed, including four independent dimensions: environmental impact, resource utilization, resource availability, and economic effectiveness. An illustrative example of comparing assessment between a gas boiler and a solar boiler process provides insight into the features of the proposed approach.

  17. Mental workload classification using heart rate metrics.

    PubMed

    Henelius, Andreas; Hirvonen, Kati; Holm, Anu; Korpela, Jussi; Muller, Kiti

    2009-01-01

    The ability of different short-term heart rate variability metrics to classify the level of mental workload (MWL) in 140 s segments was studied. Electrocardiographic data and event related potentials (ERPs), calculated from electroencephalographic data, were collected from 13 healthy subjects during the performance of a computerised cognitive multitask test with different task load levels. The amplitude of the P300 component of the ERPs was used as an objective measure of MWL. Receiver operating characteristics analysis (ROC) showed that the time domain metric of average interbeat interval length was the best-performing metric in terms of classification ability.

  18. Applying Sigma Metrics to Reduce Outliers.

    PubMed

    Litten, Joseph

    2017-03-01

    Sigma metrics can be used to predict assay quality, allowing easy comparison of instrument quality and predicting which tests will require minimal quality control (QC) rules to monitor the performance of the method. A Six Sigma QC program can result in fewer controls and fewer QC failures for methods with a sigma metric of 5 or better. The higher the number of methods with a sigma metric of 5 or better, the lower the costs for reagents, supplies, and control material required to monitor the performance of the methods.

  19. Metrics for comparison of crystallographic maps

    SciTech Connect

    Urzhumtsev, Alexandre; Afonine, Pavel V.; Lunin, Vladimir Y.; Terwilliger, Thomas C.; Adams, Paul D.

    2014-10-01

    Numerical comparison of crystallographic contour maps is used extensively in structure solution and model refinement, analysis and validation. However, traditional metrics such as the map correlation coefficient (map CC, real-space CC or RSCC) sometimes contradict the results of visual assessment of the corresponding maps. This article explains such apparent contradictions and suggests new metrics and tools to compare crystallographic contour maps. The key to the new methods is rank scaling of the Fourier syntheses. The new metrics are complementary to the usual map CC and can be more helpful in map comparison, in particular when only some of their aspects, such as regions of high density, are of interest.

  20. Kerr metric in Bondi-Sachs form

    SciTech Connect

    Bishop, Nigel T.; Venter, Liebrecht R.

    2006-04-15

    A metric representing the Kerr geometry has been obtained by Pretorius and Israel. We make coordinate transformations on this metric, to bring it into Bondi-Sachs form. We investigate the behavior of the metric near the axis of symmetry and confirm elementary flatness, and we also confirm that it is asymptotic to the Bondi-Sachs form of the Schwarzschild geometry. The results obtained here are needed so that numerical relativity codes based on the characteristic formalism can be applied to a situation that contains a rotating black hole.

  1. Assessment of proposed fighter agility metrics

    NASA Technical Reports Server (NTRS)

    Liefer, Randall K.; Valasek, John; Eggold, David P.; Downing, David R.

    1990-01-01

    This paper presents the results of an analysis of proposed metrics to assess fighter aircraft agility. A novel framework for classifying these metrics is developed and applied. A set of transient metrics intended to quantify the axial and pitch agility of fighter aircraft is evaluated with a high fidelity, nonlinear F-18 simulation. Test techniques and data reduction method are proposed, and sensitivities to pilot introduced errors during flight testing is investigated. Results indicate that the power onset and power loss parameters are promising candidates for quantifying axial agility, while maximum pitch up and pitch down rates are for quantifying pitch agility.

  2. Area Minimizing Discs in Metric Spaces

    NASA Astrophysics Data System (ADS)

    Lytchak, Alexander; Wenger, Stefan

    2017-03-01

    We solve the classical problem of Plateau in the setting of proper metric spaces. Precisely, we prove that among all disc-type surfaces with prescribed Jordan boundary in a proper metric space there exists an area minimizing disc which moreover has a quasi-conformal parametrization. If the space supports a local quadratic isoperimetric inequality for curves we prove that such a solution is locally Hölder continuous in the interior and continuous up to the boundary. Our results generalize corresponding results of Douglas Radò and Morrey from the setting of Euclidean space and Riemannian manifolds to that of proper metric spaces.

  3. Effect of length of chopped pristine and intercalated graphite fibers on the resistivity of fiber networks

    NASA Technical Reports Server (NTRS)

    Gaier, James R.; Stahl, Mark

    1988-01-01

    Samples of Amoco P-100 fibers were chopped to lengths of 3.14, 2.53, 1.90, 1.27, 0.66 mm, or milled for 2 hours. The two-point resistivity of compacts of these fibers were measured as a function of pressure from 34 kPa to 143 MPa. Samples of each fiber length were intercalated with bromine at room temperature and similarly measured. The low pressure resistivity of the compacts decreased with increasing fiber length. Intercalation lowered the resistivity of each of the chopped length compacts, but raised the resistivity of the milled fiber compacts. Bulk resistivity of all samples decreased with increasing pressure at similar rates. Even though fiber volumes were as low as 5 percent, all measurements exhibited measurable resistivity. A greater change with pressure in the resistance was observed for shorter fibers than for longer, probably an indication of tighter fiber packing. Intercalation appeared to have no effect on the fiber to fiber contact resistance.

  4. Effects of durum wheat background on the expression of hexaploid wheat-derived Fusarium head blight resistance genes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Multiple Fusarium head blight (FHB) resistance sources have been identified in common wheat, but an effective source of resistance to FHB has not found in durum wheat. Here we report preliminary results on the effects of durum background on the expression of hexaploid wheat-derived FHB resistance g...

  5. Turbulence Hazard Metric Based on Peak Accelerations for Jetliner Passengers

    NASA Technical Reports Server (NTRS)

    Stewart, Eric C.

    2005-01-01

    Calculations are made of the approximate hazard due to peak normal accelerations of an airplane flying through a simulated vertical wind field associated with a convective frontal system. The calculations are based on a hazard metric developed from a systematic application of a generic math model to 1-cosine discrete gusts of various amplitudes and gust lengths. The math model simulates the three degree-of- freedom longitudinal rigid body motion to vertical gusts and includes (1) fuselage flexibility, (2) the lag in the downwash from the wing to the tail, (3) gradual lift effects, (4) a simplified autopilot, and (5) motion of an unrestrained passenger in the rear cabin. Airplane and passenger response contours are calculated for a matrix of gust amplitudes and gust lengths. The airplane response contours are used to develop an approximate hazard metric of peak normal accelerations as a function of gust amplitude and gust length. The hazard metric is then applied to a two-dimensional simulated vertical wind field of a convective frontal system. The variations of the hazard metric with gust length and airplane heading are demonstrated.

  6. Problem formulation, metrics, open government, and on-line collaboration

    NASA Astrophysics Data System (ADS)

    Ziegler, C. R.; Schofield, K.; Young, S.; Shaw, D.

    2010-12-01

    Problem formulation leading to effective environmental management, including synthesis and application of science by government agencies, may benefit from collaborative on-line environments. This is illustrated by two interconnected projects: 1) literature-based evidence tools that support causal assessment and problem formulation, and 2) development of output, outcome, and sustainability metrics for tracking environmental conditions. Specifically, peer-production mechanisms allow for global contribution to science-based causal evidence databases, and subsequent crowd-sourced development of causal networks supported by that evidence. In turn, science-based causal networks may inform problem formulation and selection of metrics or indicators to track environmental condition (or problem status). Selecting and developing metrics in a collaborative on-line environment may improve stakeholder buy-in, the explicit relevance of metrics to planning, and the ability to approach problem apportionment or accountability, and to define success or sustainability. Challenges include contribution governance, data-sharing incentives, linking on-line interfaces to data service providers, and the intersection of environmental science and social science. Degree of framework access and confidentiality may vary by group and/or individual, but may ultimately be geared at demonstrating connections between science and decision making and supporting a culture of open government, by fostering transparency, public engagement, and collaboration.

  7. Delayed mortality effects cut the malaria transmission potential of insecticide-resistant mosquitoes

    PubMed Central

    Viana, Mafalda; Hughes, Angela; Matthiopoulos, Jason; Ranson, Hilary; Ferguson, Heather M.

    2016-01-01

    Malaria transmission has been substantially reduced across Africa through the distribution of long-lasting insecticidal nets (LLINs). However, the emergence of insecticide resistance within mosquito vectors risks jeopardizing the future efficacy of this control strategy. The severity of this threat is uncertain because the consequences of resistance for mosquito fitness are poorly understood: while resistant mosquitoes are no longer immediately killed upon contact with LLINs, their transmission potential may be curtailed because of longer-term fitness costs that persist beyond the first 24 h after exposure. Here, we used a Bayesian state-space model to quantify the immediate (within 24 h of exposure) and delayed (>24 h after exposure) impact of insecticides on daily survival and malaria transmission potential of moderately and highly resistant laboratory populations of the major African malaria vector Anopheles gambiae. Contact with LLINs reduced the immediate survival of moderately and highly resistant An. gambiae strains by 60–100% and 3–61%, respectively, and delayed mortality impacts occurring beyond the first 24 h after exposure further reduced their overall life spans by nearly one-half. In total, insecticide exposure was predicted to reduce the lifetime malaria transmission potential of insecticide-resistant vectors by two-thirds, with delayed effects accounting for at least one-half of this reduction. The existence of substantial, previously unreported, delayed mortality effects within highly resistant malaria vectors following exposure to insecticides does not diminish the threat of growing resistance, but posits an explanation for the apparent paradox of continued LLIN effectiveness in the presence of high insecticide resistance. PMID:27402740

  8. Resistivity Lows Near Paeroa Fault (TVZ, NZ) Caused by Topographic Effects

    SciTech Connect

    Risk, G.F.; Bibby, H.M.

    1995-01-01

    Modeling of two-dimensional resistivity structures has been undertaken using a finite elements scheme that allows for accurate matching of the elevation of the ground surface. With this modeling program, interpretations were made of apparent resistivities measured with the multiple-source bipole-dipole array along several lines crossing the northern part of the Paeroa Fault. On a line crossing the Paeroa Scarp near its highest point, where the throw is 425 m, the topographic effect is inferred to cause the apparent resistivities to be lowered by about 40%, which accounts for the measured resistivity anomaly at the fault scarp. At the north-west of the Waikite-Puakohurea thermal region on another line, the topographic effect of a 100 m high ridge on Mt Waikorapa causes the apparent resistivities to be reduced by about 15%. This is insufficient to explain the measured low-resistivity anomaly. Thus, low-resistivity rock is inferred to underlie the site, suggesting that the thermal region extends about 1 km further to the north-westward than previously thought.

  9. Bias voltage induced resistance switching effect in single-molecule magnets’ tunneling junction

    NASA Astrophysics Data System (ADS)

    Zhang, Zhengzhong; Jiang, Liang

    2014-09-01

    An electric-pulse-induced reversible resistance change effect in a molecular magnetic tunneling junction, consisting of a single-molecule magnet (SMM) sandwiched in one nonmagnetic and one ferromagnetic electrode, is theoretically investigated. By applying a time-varying bias voltage, the SMM's spin orientation can be manipulated with large bias voltage pulses. Moreover, the different magnetic configuration at high-resistance/low-resistance states can be ‘read out’ by utilizing relative low bias voltage. This device scheme can be implemented with current technologies (Khajetoorians et al 2013 Science 339 55) and has potential application in molecular spintronics and high-density nonvolatile memory devices.

  10. Effects of air resistance on AT-cut quartz thickness-shear resonators.

    PubMed

    Chen, Yangyang; Wang, Ji; Du, Jianke; Zhang, Weiping; Yang, Jiashi

    2013-02-01

    We study theoretically the effects of air resistance on an AT-cut quartz plate thickness-shear mode resonator. Mindlin's two-dimensional equations for coupled thickness-shear and flexural motions of piezoelectric plates are employed for the crystal resonator. The equations of a Newtonian fluid and the equations of linear acoustics are used for the shear and compressive waves in the air surrounding the resonator, respectively. Solutions for free and electrically forced vibrations are obtained. The impedance of the resonator is calculated. The effects of air resistance are examined. It is found that air viscosity causes a relative frequency shift of the order of ppm. When the material quality factor of quartz Q = 10(5), the air viscosity and compressibility both have significant effects on resonator impedance. For resonators with larger aspect ratios the effects of air resistance are weaker, and the effect of air compressibility is weaker than air viscosity.

  11. On general (α,β)-metrics of Landsberg type

    NASA Astrophysics Data System (ADS)

    Zohrehvand, M.; Maleki, H.

    2016-05-01

    In this paper, we study a class of Finsler metrics, which are defined by a Riemannian metric α and a one-form β. They are called general (α,β)-metrics. We have proven that, every Landsberg general (α,β)-metric is a Berwald metric, under a certain condition. This shows that the hunting for an unicorn, one of the longest standing open problem in Finsler geometry, cannot be successful in the class of general (α,β)-metrics.

  12. [Effects and mechanisms of plant roots on slope reinforcement and soil erosion resistance: a research review].

    PubMed

    Xiong, Yan-Mei; Xia, Han-Ping; Li, Zhi-An; Cai, Xi-An

    2007-04-01

    Plant roots play an important role in resisting the shallow landslip and topsoil erosion of slopes by raising soil shear strength. Among the models in interpreting the mechanisms of slope reinforcement by plant roots, Wu-Waldron model is a widely accepted one. In this model, the reinforced soil strength by plant roots is positively proportional to average root tensile strength and root area ratio, the two most important factors in evaluating slope reinforcement effect of plant roots. It was found that soil erosion resistance increased with the number of plant roots, though no consistent quantitative functional relationship was observed between them. The increase of soil erosion resistance by plant roots was mainly through the actions of fiber roots less than 1 mm in diameter, while fiber roots enhanced the soil stability to resist water dispersion via increasing the number and diameter of soil water-stable aggregates. Fine roots could also improve soil permeability effectively to decrease runoff and weaken soil erosion.

  13. The effect of oxygen vacancy on switching mechanism of ZnO resistive switching memory

    NASA Astrophysics Data System (ADS)

    Hu, Cong; Wang, Qi; Bai, Shuai; Xu, Min; He, Deyan; Lyu, Deyuan; Qi, Jing

    2017-02-01

    Oxygen vacancy (Vo) is believed to control the switching mechanism of metal oxide resistive switching memory. However, an accurate and quantitative theory to prove this point of view remains absent. In this letter, we propose a model combining the Poole-Frenkel effect, space charge limited current, and the modification of Vo density to simulate the current-voltage curves. The calculated results show reasonable agreements with the experimental data, which indicates that resistive switching between high resistance state and low resistance state in the devices of Al/ZnO/p+-Si is led by the density change of Vo. Furthermore, the essence of this leading effect of Vo density is explained by electrons capture and emission via oxygen vacancies. This research demonstrates the significance of Vo in theory and gives an insight into the switching mechanism.

  14. A multi-metric approach to investigate the effects of weather conditions on the demographic of a terrestrial mammal, the european badger (Meles meles).

    PubMed

    Nouvellet, Pierre; Newman, Chris; Buesching, Christina D; Macdonald, David W

    2013-01-01

    Models capturing the full effects of weather conditions on animal populations are scarce. Here we decompose yearly temperature and rainfall into mean trends, yearly amplitude of change and residual variation, using daily records. We establish from multi-model inference procedures, based on 1125 life histories (from 1987 to 2008), that European badger (Meles meles) annual mortality and recruitment rates respond to changes in mean trends and to variability in proximate weather components. Variation in mean rainfall was by far the most influential predictor in our analysis. Juvenile survival and recruitment rates were highest at intermediate levels of mean rainfall, whereas low adult survival rates were associated with only the driest, and not the wettest, years. Both juvenile and adult survival rates also exhibited a range of tolerance for residual standard deviation around daily predicted temperature values, beyond which survival rates declined. Life-history parameters, annual routines and adaptive behavioural responses, which define the badgers' climatic niche, thus appear to be predicated upon a bounded range of climatic conditions, which support optimal survival and recruitment dynamics. That variability in weather conditions is influential, in combination with mean climatic trends, on the vital rates of a generalist, wide ranging and K-selected medium-sized carnivore, has major implications for evolutionary ecology and conservation.

  15. Effect of a Home-Based Virtual Reality Intervention for Children with Cerebral Palsy Using Super Pop VR Evaluation Metrics: A Feasibility Study

    PubMed Central

    Chen, Yuping; Garcia-Vergara, Sergio; Howard, Ayanna M.

    2015-01-01

    Objective. The purpose of this pilot study was to determine whether Super Pop VR, a low-cost virtual reality (VR) system, was a feasible system for documenting improvement in children with cerebral palsy (CP) and whether a home-based VR intervention was effective. Methods. Three children with CP participated in this study and received an 8-week VR intervention (30 minutes × 5 sessions/week) using the commercial EyeToy Play VR system. Reaching kinematics measured by Super Pop VR and two fine motor tools (Bruininks-Oseretsky Test of Motor Proficiency second edition, BOT-2, and Pediatric Motor Activity Log, PMAL) were tested before, mid, and after intervention. Results. All children successfully completed the evaluations using the Super Pop VR system at home where 85% of the reaches collected were used to compute reaching kinematics, which is compatible with literature using expensive motion analysis systems. Only the child with hemiplegic CP and more impaired arm function improved the reaching kinematics and functional use of the affected hand after intervention. Conclusion. Super Pop VR proved to be a feasible evaluation tool in children with CP. PMID:26457202

  16. Clean Cities Annual Metrics Report 2009 (Revised)

    SciTech Connect

    Johnson, C.

    2011-08-01

    Document provides Clean Cities coalition metrics about the use of alternative fuels; the deployment of alternative fuel vehicles, hybrid electric vehicles (HEVs), and idle reduction initiatives; fuel economy activities; and programs to reduce vehicle miles driven.

  17. MPLS/VPN traffic engineering: SLA metrics

    NASA Astrophysics Data System (ADS)

    Cherkaoui, Omar; MacGibbon, Brenda; Blais, Michel; Serhrouchni, Ahmed

    2001-07-01

    Traffic engineering must be concerned with a broad definition of service that includes network availability, reliability and stability, as well as traditional traffic data on loss, throughput, delay and jitter. MPLS and Virtual Private Networks (VPNs) significantly contribute to security and Quality of Service (QoS) within communication networks, but there remains a need for metric measurement and evaluation. The purpose of this paper is to propose a methodology which gives a measure for LSP ( Lfew abel Switching Paths) metrics in VPN MPLS networks. We propose here a statistical method for the evaluation of those metrics. Statistical methodology is very important in this type of study since there is a large amount of data to consider. We use the notions of sample surveys, self-similar processes, linear regression, additive models and bootstrapping. The results obtained allows us to estimate the different metrics for such SLAs.

  18. Meaning Metrics: Measure, Mix, Manipulate, and Mold.

    ERIC Educational Resources Information Center

    Shaw, Jean M.

    1981-01-01

    Many learning activities designed to make metric measurement meaningful to children are described. The manufacture and use of play dough is featured. Several simple recipes for preparing dough are included. (MP)

  19. A metric to search for relevant words

    NASA Astrophysics Data System (ADS)

    Zhou, Hongding; Slater, Gary W.

    2003-11-01

    We propose a new metric to evaluate and rank the relevance of words in a text. The method uses the density fluctuations of a word to compute an index that measures its degree of clustering. Highly significant words tend to form clusters, while common words are essentially uniformly spread in a text. If a word is not rare, the metric is stable when we move any individual occurrence of this word in the text. Furthermore, we prove that the metric always increases when words are moved to form larger clusters, or when several independent documents are merged. Using the Holy Bible as an example, we show that our approach reduces the significance of common words when compared to a recently proposed statistical metric.

  20. Green Power Partnership Program Success Metrics

    EPA Pesticide Factsheets

    The U.S. EPA's Green Power Partnership is a voluntary program designed to reduce the environmental impact of electricity generation by promoting renewable energy. EPA evaluates partnership metrics annually to determine progress toward programmatic goals.