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Sample records for effective warning labels

  1. Enhancing the effectiveness of tobacco package warning labels: a social psychological perspective

    PubMed Central

    Strahan, E; White, K; Fong, G; Fabrigar, L; Zanna, M; Cameron, R

    2002-01-01

    Objective: To outline social psychological principles that could influence the psychosocial and behavioural effects of tobacco warning labels, and to inform the development of more effective tobacco warning labels. Data sources: PsycInfo and Medline literature searches and expert guided selection of principles and theories in social psychology and of tobacco warning labels, including articles, books, and reports. Conclusions: Tobacco warning labels represent a potentially effective method of influencing attitudes and behaviours. This review describes social psychological principles that could be used to guide the creation of more effective warning labels. The potential value of incorporating warning labels into a broader public health education campaign is discussed, and directions for future research are suggested. PMID:12198266

  2. Effectiveness of cigarette warning labels: examining the impact of graphics, message framing, and temporal framing.

    PubMed

    Nan, Xiaoli; Zhao, Xiaoquan; Yang, Bo; Iles, Irina

    2015-01-01

    This study examines the effectiveness of cigarette warning labels, with a specific focus on the impact of graphics, message framing (gain vs. loss), and temporal framing (present-oriented vs. future-oriented) among nonsmokers in the United States. A controlled experiment (N = 253) revealed that graphic warning labels were perceived as more effective, stronger in argument strength, and were generally liked more compared to text-only labels. In addition, loss-framed labels, compared to their gain-framed counterparts, were rated higher in perceived effectiveness, argument strength, and liking. No significant difference was observed between the present- and future-oriented frames on any of the dependent variables. Implications of the findings for antismoking communication efforts are discussed. PMID:24628288

  3. Linguistic and location effects in compliance with pesticide warning labels for amateur and professional users.

    PubMed

    Edworthy, Judy; Hellier, Elizabeth; Morley, Nicola; Grey, Clare; Aldrich, Kirsteen; Lee, Andrew

    2004-01-01

    Three studies explored amateur and professional users' compliance with pesticide warning labels. Professionals were classified as people working in a profession in which the use of pesticides is a necessary part of their job. Amateurs used pesticides only in their leisure time. The first study showed that the wording used affected perception of the appropriateness of hazard statements, one of the most effective variations being the use of the personal pronoun (statements beginning "You should..."). The location of warning information was also found to affect actual compliance: Compliance increased when warning information was presented in the directions for use section. A supplemental directive increased compliance only for professional users. In a final study, "best-case" and "worst-case" linguistic variations were combined with best-case and worst-case locations for safety information. Instruction statements using the personal pronoun and presented in the directions for use section resulted in the highest levels of compliance. The differences in compliance between amateur and professional users are interpreted within the framework of Rasmussen's (1986) distinction among skill-, rule-, and knowledge-based behavior. Actual or potential applications of this research include the design of warning labels and safety information. PMID:15151153

  4. Cigarette Warning Labels as Educational Devices.

    ERIC Educational Resources Information Center

    Newman, Ian M.; And Others

    This paper reports an investigation on the educational impact of warning labels on cigarette packages on adolescents. Subjects were asked to identify the locations of warning labels on cigarette packages and advertising and to restate the warning label. Results indicated that official warnings may be well known in general terms but poorly known in…

  5. The impacts of fear and disgust on the perceived effectiveness of smoking warning labels: a study on Turkish university students.

    PubMed

    Tugrul, Tugba Orten

    2015-03-01

    This study investigated the perceived effectiveness of pictorial warning labels on cigarette packages on Turkish university students. In particular, the impacts of fear and disgust elicited by these labels were examined using the smoking decision process model. A survey was conducted with 344 undergraduate students at a private university in Izmir, the third largest city of Turkey. The findings showed differences in levels of fear and disgust evoked by pictorial warning labels for each stage in the smoking decision process, which in turn led to differences in the perceived effectiveness of the labels. Thus, this study underlines the importance of tailoring antismoking messages according to specific target groups and also suggests considering the smoking-decision-process model as segments and targeting groups in creating effective messages.

  6. 40 CFR 763.95 - Warning labels.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.95 Warning labels. (a) The local education agency shall...: ASBESTOS. HAZARDOUS. DO NOT DISTURB WITHOUT PROPER TRAINING AND EQUIPMENT....

  7. 40 CFR 763.95 - Warning labels.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.95 Warning labels. (a) The local education agency shall...: ASBESTOS. HAZARDOUS. DO NOT DISTURB WITHOUT PROPER TRAINING AND EQUIPMENT....

  8. 40 CFR 763.95 - Warning labels.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.95 Warning labels. (a) The local education agency shall...: ASBESTOS. HAZARDOUS. DO NOT DISTURB WITHOUT PROPER TRAINING AND EQUIPMENT....

  9. 40 CFR 763.95 - Warning labels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.95 Warning labels. (a) The local education agency shall...: ASBESTOS. HAZARDOUS. DO NOT DISTURB WITHOUT PROPER TRAINING AND EQUIPMENT....

  10. Influencing of warning label signal words on perceived hazard level.

    PubMed

    Wogalter, M S; Jarrard, S W; Simpson, S N

    1994-09-01

    This experiment investigated the influence of warnings, signal words, and a signal icon on perceived hazard of consumer products. Under the guise of a marketing research study, 135 people (high school students, college students, and participants from a shopping mall) rated product labels on six dimensions, including how hazardous they perceived the products to be. A total of 16 labels from actual household products were used: 9 carried the experimental conditions, and 7 were filler product labels that never carried a warning. Five conditions presented the signal words NOTE, CAUTION, WARNING, DANGER, and LETHAL together with a brief warning message. In another two conditions, a signal icon (exclamation point surrounded by a triangle) was presented together with the terms DANGER and LETHAL. In the final two conditions, one lacked a signal word but retained the warning message, and the other lacked both the warning message and the signal word. Results showed that the presence of a signal word increased perceived product hazard compared with its absence. Significant differences were noted between extreme terms (e.g., NOTE and DANGER) but not between terms usually recommended in warning design guidelines (e.g., CAUTION and WARNING). The signal icon showed no significant effect on hazard perception. Implications of the results and the value of the methodology for future warnings investigations are discussed. PMID:7989055

  11. 40 CFR 763.95 - Warning labels.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Warning labels. 763.95 Section 763.95 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS... to be ACM located in routine maintenance areas (such as boiler rooms) at each school building....

  12. 21 CFR 501.17 - Animal food labeling warning statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Animal food labeling warning statements. 501.17... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ANIMAL FOOD LABELING General Provisions § 501.17 Animal food labeling warning statements. (a) Self-pressurized containers. (1) The label of a food packaged...

  13. 29 CFR 1915.16 - Warning signs and labels.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Warning signs and labels. 1915.16 Section 1915.16 Labor... Other Dangerous Atmospheres in Shipyard Employment § 1915.16 Warning signs and labels. (a) Employee comprehension of signs and labels. The Employer shall ensure that each sign or label posted to comply with...

  14. 29 CFR 1915.16 - Warning signs and labels.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Warning signs and labels. 1915.16 Section 1915.16 Labor... Other Dangerous Atmospheres in Shipyard Employment § 1915.16 Warning signs and labels. (a) Employee comprehension of signs and labels. The Employer shall ensure that each sign or label posted to comply with...

  15. 29 CFR 1915.16 - Warning signs and labels.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Warning signs and labels. 1915.16 Section 1915.16 Labor... Other Dangerous Atmospheres in Shipyard Employment § 1915.16 Warning signs and labels. (a) Employee comprehension of signs and labels. The Employer shall ensure that each sign or label posted to comply with...

  16. Warning labels formulated as questions positively influence smoking-related risk perception.

    PubMed

    Glock, Sabine; Müller, Barbara C N; Ritter, Simone M

    2013-02-01

    Research on warning labels printed on cigarette packages has shown that fear inducing health warnings might provoke defensive responses. This study investigated whether reformulating statements into questions could avoid defensive reactions. Smokers were presented with either warning labels formulated as questions, textual warning labels, graphic warning labels, or no warning labels. Participants' smoking-related risk perception was higher after exposure to warning labels formulated as questions or no warning labels than after exposure to textual or graphic warning labels. These results indicate that reformulating statements into questions can avoid defensive responses elicited by textual- and graphic warning labels. PMID:22419415

  17. Reactions to FDA-Proposed Graphic Warning Labels Affixed to U.S. Smokers’ Cigarette Packs

    PubMed Central

    Kreuter, Matthew W.; Boyum, Sonia; Thompson, Vetta S.; Caburnay, Charlene A.; Waters, Erika A.; Kaphingst, Kimberly A.; Rath, Suchitra; Fu, Qiang

    2015-01-01

    Introduction: Graphic warning labels have been shown to be more effective than text-only labels in increasing attention and perceived health risks, but most U.S. studies have involved single exposures in laboratory or Internet settings. Methods: We recruited a convenience sample (N = 202) of U.S. adult smokers from population subgroups with higher rates of smoking and smoking-related deaths who had participated in a larger survey about graphic warning labels. Participants were randomized to get 1 of 9 graphic + text labels or a text-only label. Research staff affixed a warning label sticker to participants’ cigarette pack(s) at enrollment. Color graphic labels covered slightly more than the lower half of packs. Black and white labels of current U.S. text-only warnings covered the existing side warning to prompt attention to the label (i.e., attention control). Participants received extra stickers of the same label for subsequent packs, and completed 3 telephone interviews in 1 week. Results: Participants reported low avoidance (<34%) and consistent use of the stickers (91%). Smokers consistently paid more attention to graphic than text-only labels. Only 5 of the 9 graphic warning labels were significantly associated with greater thoughts of health risks. Thinking about quitting and stopping smoking did not differ by label. Qualitative data illustrated differences in the “stickiness,” self-referencing, and counterarguments of graphic warning labels. Conclusions: U.S. smokers’ reactions to graphic warning labels on their own packs were similar to other, more controlled studies. Qualitative findings underscore the need for warning labels that encourage self-referential processing without increasing defensive reactions. PMID:25589676

  18. Effect of the Framework Convention on Tobacco Control and Voluntary Industry Health Warning Labels on Passage of Mandated Cigarette Warning Labels From 1965 to 2012: Transition Probability and Event History Analyses

    PubMed Central

    Sanders-Jackson, Ashley N.; Song, Anna V.; Hiilamo, Heikki

    2013-01-01

    Objectives. We quantified the pattern and passage rate of cigarette package health warning labels (HWLs), including the effect of the Framework Convention on Tobacco Control (FCTC) and HWLs voluntarily implemented by tobacco companies. Methods. We used transition probability matrices to describe the pattern of HWL passage and change rate in 4 periods. We used event history analysis to estimate the effect of the FCTC on adoption and to compare that effect between countries with voluntary and mandatory HWLs. Results. The number of HWLs passed during each period accelerated, from a transition rate among countries that changed from 2.42 per year in 1965–1977 to 6.71 in 1977–1984, 8.42 in 1984–2003, and 22.33 in 2003–2012. The FCTC significantly accelerated passage of FCTC-compliant HWLs for countries with initially mandatory policies with a hazard of 1.27 per year (95% confidence interval = 1.11, 1.45), but only marginally increased the hazard for countries that had an industry voluntary HWL of 1.68 per year (95% confidence interval = 0.95, 2.97). Conclusions. Passage of HWLs is accelerating, and the FCTC is associated with further acceleration. Industry voluntary HWLs slowed mandated HWLs. PMID:24028248

  19. 10 CFR 850.38 - Warning signs and labels.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CONTAMINATED WITH BERYLLIUM DO NOT REMOVE DUST BY BLOWING OR SHAKING CANCER AND LUNG DISEASE HAZARD (c) Warning signs and labels must be in accordance with 29 CFR 1910.1200, Hazard Communication. ... CANCER HAZARD AUTHORIZED PERSONNEL ONLY (b) Warning labels. (1) The responsible employer must...

  20. 10 CFR 850.38 - Warning signs and labels.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CONTAMINATED WITH BERYLLIUM DO NOT REMOVE DUST BY BLOWING OR SHAKING CANCER AND LUNG DISEASE HAZARD (c) Warning signs and labels must be in accordance with 29 CFR 1910.1200, Hazard Communication. ... CANCER HAZARD AUTHORIZED PERSONNEL ONLY (b) Warning labels. (1) The responsible employer must...

  1. 10 CFR 850.38 - Warning signs and labels.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CONTAMINATED WITH BERYLLIUM DO NOT REMOVE DUST BY BLOWING OR SHAKING CANCER AND LUNG DISEASE HAZARD (c) Warning signs and labels must be in accordance with 29 CFR 1910.1200, Hazard Communication. ... CANCER HAZARD AUTHORIZED PERSONNEL ONLY (b) Warning labels. (1) The responsible employer must...

  2. 10 CFR 850.38 - Warning signs and labels.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CONTAMINATED WITH BERYLLIUM DO NOT REMOVE DUST BY BLOWING OR SHAKING CANCER AND LUNG DISEASE HAZARD (c) Warning signs and labels must be in accordance with 29 CFR 1910.1200, Hazard Communication. ... CANCER HAZARD AUTHORIZED PERSONNEL ONLY (b) Warning labels. (1) The responsible employer must...

  3. 10 CFR 850.38 - Warning signs and labels.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CONTAMINATED WITH BERYLLIUM DO NOT REMOVE DUST BY BLOWING OR SHAKING CANCER AND LUNG DISEASE HAZARD (c) Warning signs and labels must be in accordance with 29 CFR 1910.1200, Hazard Communication. ... CANCER HAZARD AUTHORIZED PERSONNEL ONLY (b) Warning labels. (1) The responsible employer must...

  4. Cigarette Warning Label Policy Alternatives and Smoking-Related Health Disparities

    PubMed Central

    Thrasher, James F.; Carpenter, Matthew J.; Andrews, Jeannette O.; Gray, Kevin M.; Alberg, Anthony J.; Navarro, Ashley; Friedman, Daniela B.; Cummings, K. Michael

    2012-01-01

    Background Pictorial health warning labels on cigarette packaging have been proposed for the U.S., but their potential influences among populations that suffer tobacco-related health disparities are unknown. Purpose To evaluate pictorial health warning labels, including moderation of their influences by health literacy and race. Methods From July 2011 to January 2012, field experiments were conducted with 981 adult smokers who were randomized to control (i.e., text-only labels, n=207) and experimental conditions (i.e., pictorial labels, n=774). The experimental condition systematically varied health warning label stimuli by health topic and image type. Linear mixed effects (LME) models estimated the influence of health warning label characteristics and participant characteristics on label ratings. Data were analyzed from January 2012 to April 2012. Results Compared to text-only warning labels, pictorial warning labels were rated as more personally relevant (5.7 vs 6.8, p<0.001) and effective (5.4 vs 6.8, p<0.001), and as more credible, but only among participants with low health literacy (7.6 vs 8.2, p<0.001). Within the experimental condition, pictorial health warning labels with graphic imagery had significantly higher ratings of credibility, personal relevance, and effectiveness than imagery of human suffering and symbolic imagery. Significant interactions indicated that labels with graphic imagery produced minimal differences in ratings across racial groups and levels of health literacy, whereas other imagery produced greater group differences. Conclusions Pictorial health warning labels with graphic images have the most-pronounced short-term impacts on adult smokers, including smokers from groups that have in the past been hard to reach. PMID:23159254

  5. 21 CFR 501.17 - Animal food labeling warning statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part 82. ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Animal food labeling warning statements. 501.17... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ANIMAL FOOD LABELING General Provisions § 501.17...

  6. 21 CFR 501.17 - Animal food labeling warning statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part 82. ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Animal food labeling warning statements. 501.17... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ANIMAL FOOD LABELING General Provisions § 501.17...

  7. 21 CFR 501.17 - Animal food labeling warning statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part 82. ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Animal food labeling warning statements. 501.17... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ANIMAL FOOD LABELING General Provisions § 501.17...

  8. 48 CFR 252.223-7001 - Hazard warning labels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... label the item package (unit container) of any hazardous material to be delivered under this contract in accordance with the Hazard Communication Standard (29 CFR 1910.1200 et seq). The Standard requires that the hazard warning label conform to the requirements of the standard unless the material is otherwise...

  9. 48 CFR 252.223-7001 - Hazard warning labels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... label the item package (unit container) of any hazardous material to be delivered under this contract in accordance with the Hazard Communication Standard (29 CFR 1910.1200 et seq). The Standard requires that the hazard warning label conform to the requirements of the standard unless the material is otherwise...

  10. 48 CFR 252.223-7001 - Hazard warning labels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... label the item package (unit container) of any hazardous material to be delivered under this contract in accordance with the Hazard Communication Standard (29 CFR 1910.1200 et seq). The Standard requires that the hazard warning label conform to the requirements of the standard unless the material is otherwise...

  11. 48 CFR 252.223-7001 - Hazard warning labels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... label the item package (unit container) of any hazardous material to be delivered under this contract in accordance with the Hazard Communication Standard (29 CFR 1910.1200 et seq). The Standard requires that the hazard warning label conform to the requirements of the standard unless the material is otherwise...

  12. Low Literacy Impairs Comprehension of Prescription Drug Warning Labels

    PubMed Central

    Davis, Terry C; Wolf, Michael S; Bass, Pat F; Middlebrooks, Mark; Kennen, Estela; Baker, David W; Bennett, Charles L; Durazo-Arvizu, Ramon; Bocchini, Anna; Savory, Stephanie; Parker, Ruth M

    2006-01-01

    BACKGROUND Adverse events resulting from medication error are a serious concern. Patients' literacy and their ability to understand medication information are increasingly seen as a safety issue. OBJECTIVE To examine whether adult patients receiving primary care services at a public hospital clinic were able to correctly interpret commonly used prescription medication warning labels. DESIGN In-person structured interviews with literacy assessment. SETTING Public hospital, primary care clinic. PARTICIPANTS A total of 251 adult patients waiting for an appointment at the Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S) Primary Care Clinic. MEASUREMENTS Correct interpretation, as determined by expert panel review of patients' verbatim responses, for each of 8 commonly used prescription medication warning labels. RESULTS Approximately one-third of patients (n=74) were reading at or below the 6th-grade level (low literacy). Patient comprehension of warning labels was associated with one's literacy level. Multistep instructions proved difficult for patients across all literacy levels. After controlling for relevant potential confounding variables, patients with low literacy were 3.4 times less likely to interpret prescription medication warning labels correctly (95% confidence interval: 2.3 to 4.9). CONCLUSIONS Patients with low literacy had difficulty understanding prescription medication warning labels. Patients of all literacy levels had better understanding of warning labels that contained single-step versus multiple-step instructions. Warning labels should be developed with consumer participation, especially with lower literate populations, to ensure comprehension of short, concise messages created with familiar words and recognizable icons. PMID:16881945

  13. Adult Smokers’ Reactions to Pictorial Health Warning Labels on Cigarette Packs in Thailand and Moderating Effects of Type of Cigarette Smoked: Findings From the International Tobacco Control Southeast Asia Survey

    PubMed Central

    2013-01-01

    Introduction: In this study, we aimed to examine, in Thailand, the impact on smokers’ reported awareness of and their cognitive and behavioral reactions following the change from text-only to pictorial warnings printed on cigarette packs. We also sought to explore differences by type of cigarette smoked (roll-your-own [RYO] vs. factory-made [FM] cigarettes). Methods: Data came from the International Tobacco Control Southeast Asia Survey, conducted in Thailand and Malaysia, where a representative sample of 2,000 adult smokers from each country were recruited and followed up. We analyzed data from one wave before (Wave 1) and two waves after the implementation of the new pictorial warnings (two sets introduced at Waves 2 and 3, respectively) in Thailand, with Malaysia, having text-only warnings, serving as a control. Results: Following the warning label change in Thailand, smokers’ reported awareness and their cognitive and behavioral reactions increased markedly, with the cognitive and behavioral effects sustained at the next follow-up. By contrast, no significant change was observed in Malaysia over the same period. Compared to smokers who smoke any FM cigarettes, smokers of only RYO cigarettes reported a lower salience but greater cognitive reactions to the new pictorial warnings. Conclusions: The new Thai pictorial health warning labels have led to a greater impact than the text-only warning labels, and refreshing the pictorial images may have helped sustain effects. This finding provides strong support for introducing pictorial warning labels in low- and middle-income countries, where the benefits may be even greater, given the lower literacy rates and generally lower levels of readily available health information on the risks of smoking. PMID:23291637

  14. Emotional reaction facilitates the brain and behavioral impact of graphic cigarette warning labels in smokers

    PubMed Central

    Wang, An-Li; Lowen, Steven B; Romer, Daniel; Giorno, Mario; Langleben, Daniel D

    2015-01-01

    Background Warning labels on cigarette packages are an important venue for information about the hazards of smoking. The 2009 US Family Smoking Prevention and Tobacco Control Act mandated replacing the current text-only labels with graphic warning labels. However, labels proposed by the Food and Drug Administration (FDA) were challenged in court by the tobacco companies, who argued successfully that the proposed labels needlessly encroached on their right to free speech, in part because they included images of high emotional salience that indiscriminately frightened rather than informed consumers. Methods We used functional MRI to examine the effects of graphic warning labels' emotional salience on smokers' brain activity and cognition. Twenty-four smokers viewed a random sequence of blocks of graphic warning labels that have been rated high or low on an ‘emotional reaction’ scale in previous research. Results We found that labels rated high on emotional reaction were better remembered, associated with reduction in the urge to smoke, and produced greater brain response in the amygdala, hippocampi, inferior frontal gyri and the insulae. Conclusions Recognition memory and craving are, respectively, correlates of effectiveness of addiction related public health communications and interventions, and amygdala activation facilitates the encoding of emotional memories. Thus, our results suggest that emotional reaction to graphic warning labels contributes to their public health impact and may be an integral part of the neural mechanisms underlying their effectiveness. Given the urgency of the debate about the constitutional risks and public health benefits of graphic warning labels, these preliminary findings warrant consideration while longitudinal clinical studies are underway PMID:25564288

  15. Examining Interpretations of Graphic Cigarette Warning Labels Among U.S. Youth and Adults.

    PubMed

    McQueen, Amy; Waters, Erika A; Kaphingst, Kimberly A; Caburnay, Charlene A; Sanders Thompson, Vetta L; Boyum, Sonia; Kreuter, Matthew W

    2016-08-01

    Few studies have examined how diverse populations interpret warning labels. This study examined interpretations of 9 graphic cigarette warning labels (image plus text) proposed by the U.S. Food and Drug Administration among a convenience sample of youth (ages 13-17) and adults (18+) across the United States. Participants (N = 1,571) completed a cross-sectional survey. Participants were asked to select 1 of 3 plausible interpretations (1 preferred vs. 2 alternative) created by the research team about the particular consequence of smoking addressed in each warning label. Participants also rated each label for novelty, counterarguing, perceived effectiveness, and harm. Smokers reported their thoughts of quitting, self-efficacy, and motivation to quit. Although at least 70% of the sample chose the preferred interpretation for 7 of 9 labels, only 13% of participants chose all 9 preferred interpretations. The odds of selecting the preferred interpretation were lower among African Americans, among those with less education, and for labels perceived as being more novel. Smokers reported greater counterarguing and less perceived effectiveness and harms than nonsmokers, but results were not consistent across all labels and interpretations. The alternative interpretations of cigarette warning labels were associated with lower perceived effectiveness and lower perceived harms of smoking, both of which are important for motivating quit attempts. PMID:27410753

  16. Interpretations of cigarette advertisement warning labels by Philadelphia Puerto Ricans.

    PubMed

    Morris, Nancy; Gilpin, Dawn R; Lenos, Melissa; Hobbs, Renee

    2011-09-01

    This study examined Philadelphia Puerto Ricans' interpretations of the Surgeon General's warnings that appear on cigarette packaging and in advertisements. In-home family focus groups in which participants were asked to comment on magazine cigarette advertisements showed a great variety of interpretations of the legally mandated warning labels. These findings (a) corroborate and add to research in public health and communications regarding the possibility of wide variations in message interpretations and (b) support the call for public health messages to be carefully tested for effectiveness among different social groups. The article's focus on Puerto Ricans addresses the problem of misleading conclusions that can arise from aggregating all Latino subpopulations into one group. The use of a naturalistic setting to examine interpretations of messages about smoking departs from the experimental methods typically used for such research and provides new evidence that even a seemingly straightforward message can be interpreted in multiple ways. Understanding and addressing differences in message interpretation can guide public health campaigns aimed at reducing health disparities. PMID:21534024

  17. 48 CFR 252.223-7001 - Hazard warning labels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Hazard warning labels. 252.223-7001 Section 252.223-7001 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.223-7001...

  18. 21 CFR 501.17 - Animal food labeling warning statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part 82. ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Animal food labeling warning statements. 501.17 Section 501.17 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN...

  19. 29 CFR 1915.16 - Warning signs and labels.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) OCCUPATIONAL SAFETY AND HEALTH STANDARDS FOR SHIPYARD EMPLOYMENT Confined and Enclosed Spaces and Other Dangerous Atmospheres in Shipyard Employment § 1915.16 Warning signs and labels. (a)...

  20. 29 CFR 1915.16 - Warning signs and labels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) OCCUPATIONAL SAFETY AND HEALTH STANDARDS FOR SHIPYARD EMPLOYMENT Confined and Enclosed Spaces and Other Dangerous Atmospheres in Shipyard Employment § 1915.16 Warning signs and labels. (a)...

  1. Reactions of Nepali Adults to Warning Labels on Cigarette Packages: A Survey with Employee and Medical Students of a Tertiary Care Medical College of Western Region of Nepal

    PubMed Central

    Paudel, Badri; Paudel, Klara; Timilsina, Deepa

    2013-01-01

    Background: For the past 30 years, there have been no changes in the text-only cigarette warning labels in Nepal. During this same time period, other countries placed large graphic warning labels on cigarette packages. The purpose of the current study was primarily to compare the differences in reactions to different types of warning labels on cigarette packages, with a specific focus on whether the new warning label adopted by WHO FCTC was better than the text only label used by Nepal. Material and Methods: This study was conducted in Gandaki Medical College Teaching Hospital (GMCTH) in 2012, in a tertiary care hospital located in the western region of Nepal. Eligible study participants included in this survey were those aged 18 years and over and those who are studying MBBS/Nursing or who were employees of GMCTH. 500 participants finished the survey. Participants were shown nine types of warning labels found on cigarette packages.They comprised one text only warning label used within Nepalese market and eight foreign brand labels. Participants were asked about the impact of the warning labels on: their knowledge of harm from smoking, giving cigarettes as a gift, and quitting smoking. Results: On comparing the Nepalese warning label with other foreign labels with regards to providing knowledge of harm warning, impact of quitting smoking and giving cigarettes as a gift, the overseas labels were found to be more effective. Both smokers and non–smokers thought that warning labels with text plus graphics were substantially more of a deterrent than text-only labels. Conclusion: The findings from this study support previous research that has found that text-plus graphic warning labels were more salient and potentially more effective than text-only labels.Warning labels are one of the component of comprehensive tobacco control and smoking cessation efforts. Stronger warnings on cigarette packages need to be part of a larger Nepalese public health educational efforts

  2. Perceptions of prescription warning labels within an underserved population

    PubMed Central

    Shiyanbola, Olayinka O.; Meyer, Brittney A.; Locke, Michelle R.; Wettergreen, Sara

    Objective To understand how underserved populations attend to prescription warning label (PWL) instructions, examine the importance of PWL instructions to participants and describe the challenges associated with interpreting the information on PWLs. Methods Adults from an underserved population (racial and ethnic minorities, individuals with low income, older adults) who had a history of prescription medication use and were able to understand English took part in semi-structured interviews. Participants were presented with eight different prescription bottles with an attached PWL. Participants were asked, “If this prescription was yours, what information would you need to know about the medicine?” The number of participants who attended to the warning labels was noted. Other questions assessed the importance of PWLs, the challenges with understanding PWLs, and ways a pharmacist could help participant understanding of the PWL. Results There were 103 participants. The mean age was 50.25 years (SD=18.05). Majority attended to the PWL. Participants not currently taking medications and who had limited health literacy were likely to overlook the warning labels. Majority rated the warning instructions to be extremely important (n=86, 83.5 %), wanted the pharmacist to help them understand PWLs by counseling them on the information on the label (n=63, 61.2%), and thought the graphics made the label information easy to understand. Conclusions PWLs are an important method of communicating medication information, as long as they are easily comprehensible to patients. In addition to placing PWLs on prescription bottles, health care providers need to counsel underserved populations on medication warnings, especially individuals with limited health literacy who are not currently using a prescription medication. PMID:24644523

  3. History and evolution of warning labels for automotive friction products.

    PubMed

    Kopelovich, Luda M; Thuett, Kerry A; Chapman, Pamela S; Paustenbach, Dennis J

    2014-04-01

    There have been claims over the years that asbestos-containing product manufacturers did not sufficiently warn end users early enough regarding the potential health hazards associated with their products (1930s-1990s). To address this issue, we compared the content of the warnings associated with asbestos-containing friction products (brakes, clutches, and gaskets) manufactured by the US automotive industries to what was expected by regulatory agencies during the time period in which an understanding of asbestos health hazards was being developed. We ended our evaluation around 1990, since asbestos-containing manufacturer supplied automotive products were functionally removed from commerce by 1985 in the United States. We assessed the warnings issued in users' manuals, technical service bulletins, product packaging materials, and labels placed on products themselves. Based on our evaluation, regulatory agencies had no guidelines regarding specific warning language for finished friction products, particularly when a product contained encapsulated asbestos fibers (i.e., modified by a bonding agent). Even today, federal regulations do not require labeling on encapsulated products when, based on professional judgment or sampling, user exposure is not expected to exceed the OSHA PEL. We concluded that, despite limited regulatory guidance, the US automotive industry provided adequate warnings with regards to its friction products. PMID:24518387

  4. History and evolution of warning labels for automotive friction products.

    PubMed

    Kopelovich, Luda M; Thuett, Kerry A; Chapman, Pamela S; Paustenbach, Dennis J

    2014-04-01

    There have been claims over the years that asbestos-containing product manufacturers did not sufficiently warn end users early enough regarding the potential health hazards associated with their products (1930s-1990s). To address this issue, we compared the content of the warnings associated with asbestos-containing friction products (brakes, clutches, and gaskets) manufactured by the US automotive industries to what was expected by regulatory agencies during the time period in which an understanding of asbestos health hazards was being developed. We ended our evaluation around 1990, since asbestos-containing manufacturer supplied automotive products were functionally removed from commerce by 1985 in the United States. We assessed the warnings issued in users' manuals, technical service bulletins, product packaging materials, and labels placed on products themselves. Based on our evaluation, regulatory agencies had no guidelines regarding specific warning language for finished friction products, particularly when a product contained encapsulated asbestos fibers (i.e., modified by a bonding agent). Even today, federal regulations do not require labeling on encapsulated products when, based on professional judgment or sampling, user exposure is not expected to exceed the OSHA PEL. We concluded that, despite limited regulatory guidance, the US automotive industry provided adequate warnings with regards to its friction products.

  5. Effects of exposure to thin-ideal media images on body dissatisfaction: testing the inclusion of a disclaimer versus warning label.

    PubMed

    Ata, Rheanna N; Thompson, J Kevin; Small, Brent J

    2013-09-01

    The current study was designed to determine whether the inclusion of a disclaimer (i.e., "Retouched photograph aimed at changing a person's physical appearance.") or warning (i.e., "Warning: Trying to look as thin as this model may be dangerous to your health.") added to images of thin/attractive models would affect body dissatisfaction and intent to diet in female undergraduate students (n=342). Participants were randomly assigned to one of four groups: (a) disclaimer, (b) warning, (c) model control, or (d) car control. Results revealed a significant interaction between group and time, whereby only the car control group reported a significant change (i.e., decrease) in body dissatisfaction over time. Groups did not differ on intent to diet measured at post-exposure. The results largely replicate other findings in this area and call into question advocacy efforts to label media images as a strategy to decrease women's identification with the stimuli. PMID:23688859

  6. The evolution of health warning labels on cigarette packs: the role of precedents, and tobacco industry strategies to block diffusion

    PubMed Central

    Hiilamo, Heikki; Crosbie, Eric; Glantz, Stanton A

    2013-01-01

    Objective To analyse the evolution and diffusion of health warnings on cigarette packs around the world, including tobacco industry attempts to block this diffusion. Methods We analysed tobacco industry documents and public sources to construct a database on the global evolution and diffusion of health warning labels from 1966 to 2012, and also analysed industry strategies. Results Health warning labels, especially labels with graphic elements, threaten the tobacco industry because they are a low-cost, effective measure to reduce smoking. Multinational tobacco companies did not object to voluntary innocuous warnings with ambiguous health messages, in part because they saw them as offering protection from lawsuits and local packaging regulations. The companies worked systematically at the international level to block or weaken warnings once stronger more specific warnings began to appear in the 1970s. Since 1985 in Iceland, the tobacco industry has been aware of the effectiveness of graphic health warning labels (GWHL). The industry launched an all-out attack in the early 1990s to prevent GHWLs, and was successful in delaying GHWLs internationally for nearly 10 years. Conclusions Beginning in 2005, as a result of the World Health Organisation Framework Convention on Tobacco Control (FCTC), GHWLs began to spread. Effective implementation of FCTC labelling provisions has stimulated diffusion of strong health warning labels despite industry opposition. PMID:23092884

  7. Graphic Warning Labels Elicit Affective and Thoughtful Responses from Smokers: Results of a Randomized Clinical Trial

    PubMed Central

    Evans, Abigail T.; Peters, Ellen; Strasser, Andrew A.; Emery, Lydia F.; Sheerin, Kaitlin M.; Romer, Daniel

    2015-01-01

    Objective Observational research suggests that placing graphic images on cigarette warning labels can reduce smoking rates, but field studies lack experimental control. Our primary objective was to determine the psychological processes set in motion by naturalistic exposure to graphic vs. text-only warnings in a randomized clinical trial involving exposure to modified cigarette packs over a 4-week period. Theories of graphic-warning impact were tested by examining affect toward smoking, credibility of warning information, risk perceptions, quit intentions, warning label memory, and smoking risk knowledge. Methods Adults who smoked between 5 and 40 cigarettes daily (N = 293; mean age = 33.7), did not have a contra-indicated medical condition, and did not intend to quit were recruited from Philadelphia, PA and Columbus, OH. Smokers were randomly assigned to receive their own brand of cigarettes for four weeks in one of three warning conditions: text only, graphic images plus text, or graphic images with elaborated text. Results Data from 244 participants who completed the trial were analyzed in structural-equation models. The presence of graphic images (compared to text-only) caused more negative affect toward smoking, a process that indirectly influenced risk perceptions and quit intentions (e.g., image->negative affect->risk perception->quit intention). Negative affect from graphic images also enhanced warning credibility including through increased scrutiny of the warnings, a process that also indirectly affected risk perceptions and quit intentions (e.g., image->negative affect->risk scrutiny->warning credibility->risk perception->quit intention). Unexpectedly, elaborated text reduced warning credibility. Finally, graphic warnings increased warning-information recall and indirectly increased smoking-risk knowledge at the end of the trial and one month later. Conclusions In the first naturalistic clinical trial conducted, graphic warning labels are more effective

  8. Appalachian residents' perspectives on new U.S. cigarette warning labels.

    PubMed

    Reiter, Paul L; Broder-Oldach, Benjamin; Wewers, Mary Ellen; Klein, Elizabeth G; Paskett, Electra D; Katz, Mira L

    2012-12-01

    The U.S. Food and Drug Administration revealed new pictorial warning labels in June 2011 for cigarette packages, yet little is known about how these labels are perceived by U.S. residents. We examined the reactions to and attitudes about the new labels among residents of Appalachian Ohio, a region with a high smoking prevalence. We conducted focus groups with Appalachian Ohio residents between July and October 2011. Participants included healthcare providers (n = 30), community leaders (n = 26), parents (n = 28), and young adult men ages 18-26 (n = 18). Most participants supported the addition of the new labels to U.S. cigarette packages, though many were unaware of the labels prior to the focus groups. Participants did not think the labels would be effective in promoting smoking cessation among smokers in their communities, but they were more positive about the potential of the labels to reduce smoking initiation. Participants reported positive feedback about the more graphic labels, particularly those showing a man with a tracheal stoma or a person with severe oral disease. The labels that include a cartoon image of an ill infant and a man who quit smoking received the most negative feedback. Participants generally supported adding pictorial warning labels to U.S. cigarette packages, but only a few of labels received mostly positive feedback. Results offer early insight into how the new labels may be received if they are put into practice. PMID:22527659

  9. FDA cigarette warning labels lower craving and elicit frontoinsular activation in adolescent smokers

    PubMed Central

    Do, Kathy T.

    2015-01-01

    Cigarette smoking is an economically and epidemiologically expensive public health concern. Most adult smokers become addicted during adolescence, rendering it a crucial period for prevention and intervention. Although litigation claims have delayed implementation, graphic warning labels proposed by the U.S. Food and Drug Administration (FDA) may be a promising way to achieve this goal. We aimed to determine the efficacy of the labels in reducing in-scanner craving and to characterize the neurobiological responses in adolescent and adult smokers and non-smokers. While undergoing functional magnetic resonance imaging, thirty-nine 13- to 18-year-old adolescent and forty-one 25- to 30-year-old adult smokers and non-smokers rated their desire to smoke when presented with emotionally graphic warning labels and comparison non-graphic labels. Compared with adult smokers, adolescent smokers exhibited greater craving reduction in response to the warning labels. Although smokers evinced overall blunted recruitment of insula and dorsolateral prefrontal cortex (DLPFC) relative to non-smokers, an effect that was stronger in adolescent smokers, parametrically increasing activation of these regions was associated with greater craving reduction. Functional connectivity analyses suggest that greater DLPFC regulation of limbic regions predicted cigarette craving. These data underscore a prominent role of frontoinsular circuitry in predicting the efficacy of FDA graphic warning labels in craving reduction in adult and adolescent smokers. PMID:25887154

  10. FDA cigarette warning labels lower craving and elicit frontoinsular activation in adolescent smokers.

    PubMed

    Do, Kathy T; Galván, Adriana

    2015-11-01

    Cigarette smoking is an economically and epidemiologically expensive public health concern. Most adult smokers become addicted during adolescence, rendering it a crucial period for prevention and intervention. Although litigation claims have delayed implementation, graphic warning labels proposed by the U.S. Food and Drug Administration (FDA) may be a promising way to achieve this goal. We aimed to determine the efficacy of the labels in reducing in-scanner craving and to characterize the neurobiological responses in adolescent and adult smokers and non-smokers. While undergoing functional magnetic resonance imaging, thirty-nine 13- to 18-year-old adolescent and forty-one 25- to 30-year-old adult smokers and non-smokers rated their desire to smoke when presented with emotionally graphic warning labels and comparison non-graphic labels. Compared with adult smokers, adolescent smokers exhibited greater craving reduction in response to the warning labels. Although smokers evinced overall blunted recruitment of insula and dorsolateral prefrontal cortex (DLPFC) relative to non-smokers, an effect that was stronger in adolescent smokers, parametrically increasing activation of these regions was associated with greater craving reduction. Functional connectivity analyses suggest that greater DLPFC regulation of limbic regions predicted cigarette craving. These data underscore a prominent role of frontoinsular circuitry in predicting the efficacy of FDA graphic warning labels in craving reduction in adult and adolescent smokers.

  11. FDA cigarette warning labels lower craving and elicit frontoinsular activation in adolescent smokers.

    PubMed

    Do, Kathy T; Galván, Adriana

    2015-11-01

    Cigarette smoking is an economically and epidemiologically expensive public health concern. Most adult smokers become addicted during adolescence, rendering it a crucial period for prevention and intervention. Although litigation claims have delayed implementation, graphic warning labels proposed by the U.S. Food and Drug Administration (FDA) may be a promising way to achieve this goal. We aimed to determine the efficacy of the labels in reducing in-scanner craving and to characterize the neurobiological responses in adolescent and adult smokers and non-smokers. While undergoing functional magnetic resonance imaging, thirty-nine 13- to 18-year-old adolescent and forty-one 25- to 30-year-old adult smokers and non-smokers rated their desire to smoke when presented with emotionally graphic warning labels and comparison non-graphic labels. Compared with adult smokers, adolescent smokers exhibited greater craving reduction in response to the warning labels. Although smokers evinced overall blunted recruitment of insula and dorsolateral prefrontal cortex (DLPFC) relative to non-smokers, an effect that was stronger in adolescent smokers, parametrically increasing activation of these regions was associated with greater craving reduction. Functional connectivity analyses suggest that greater DLPFC regulation of limbic regions predicted cigarette craving. These data underscore a prominent role of frontoinsular circuitry in predicting the efficacy of FDA graphic warning labels in craving reduction in adult and adolescent smokers. PMID:25887154

  12. Implementation of effective cigarette health warning labels among low and middle income countries: State capacity, path-dependency and tobacco industry activity

    PubMed Central

    Hiilamo, Heikki; Glantz, Stanton A.

    2014-01-01

    We investigates the effects of ratifying the WHO Framework Convention of Tobacco Control (FTCT), state capacity, path-dependency and tobacco industry activity on the implementation of effective health warning labels (HWL) on cigarette packs among low and middle income countries (LMIC). Using logistic regression in separate analyses for FCTC Article 11 compliant HWLs and graphic HWLs (GHWL), we found that the odds of FCTC compliance increased by a factor of 1.31 for each year after FCTC entered into force in the country (p<0.01). The odds of passing GHWLs increased by a factor of 1.46 (p<0.05) per year after FCTC entered into force. The weaker the capacity of the states were, the less likely they were to have implemented FCTC compliant HWLs (p<0.05). The countries with voluntary HWLs in 1992 were less likely (OR= 0.19, p<0.01) to comply with FCTC 21 years later (in 2013). The FCTC has promoted HWL policies among LMICs. Public health regulations require investments in broader state capacity. As the theory of path-dependency predicts voluntary agreements have long lasting influence on the direction of tobacco control in a country. Adopting voluntary HWL policies reduced likelihood of having FCTC compliant HWLs decades later. The fact that voluntary agreements delayed effective tobacco regulations suggests that policymakers must be careful of accepting industry efforts for voluntary agreements in other areas of public health as well, such as alcohol and junk food. PMID:25462428

  13. Implementation of effective cigarette health warning labels among low and middle income countries: state capacity, path-dependency and tobacco industry activity.

    PubMed

    Hiilamo, Heikki; Glantz, Stanton A

    2015-01-01

    We investigates the effects of ratifying the WHO Framework Convention of Tobacco Control (FTCT), state capacity, path-dependency and tobacco industry activity on the implementation of effective health warning labels (HWL) on cigarette packs among low and middle income countries (LMIC). Using logistic regression in separate analyses for FCTC Article 11 compliant HWLs and graphic HWLs (GHWL), we found that the odds of FCTC compliance increased by a factor of 1.31 for each year after FCTC entered into force in the country (p < 0.01). The odds of passing GHWLs increased by a factor of 1.46 (p < 0.05) per year after FCTC entered into force. The weaker the capacity of the states were, the less likely they were to have implemented FCTC compliant HWLs (p < 0.05). The countries with voluntary HWLs in 1992 were less likely (OR = 0.19, p < 0.01) to comply with FCTC 21 years later (in 2013). The FCTC has promoted HWL policies among LMICs. Public health regulations require investments in broader state capacity. As the theory of path-dependency predicts voluntary agreements have long lasting influence on the direction of tobacco control in a country. Adopting voluntary HWL policies reduced likelihood of having FCTC compliant HWLs decades later. The fact that voluntary agreements delayed effective tobacco regulations suggests that policymakers must be careful of accepting industry efforts for voluntary agreements in other areas of public health as well, such as alcohol and junk food.

  14. Implementation of effective cigarette health warning labels among low and middle income countries: state capacity, path-dependency and tobacco industry activity.

    PubMed

    Hiilamo, Heikki; Glantz, Stanton A

    2015-01-01

    We investigates the effects of ratifying the WHO Framework Convention of Tobacco Control (FTCT), state capacity, path-dependency and tobacco industry activity on the implementation of effective health warning labels (HWL) on cigarette packs among low and middle income countries (LMIC). Using logistic regression in separate analyses for FCTC Article 11 compliant HWLs and graphic HWLs (GHWL), we found that the odds of FCTC compliance increased by a factor of 1.31 for each year after FCTC entered into force in the country (p < 0.01). The odds of passing GHWLs increased by a factor of 1.46 (p < 0.05) per year after FCTC entered into force. The weaker the capacity of the states were, the less likely they were to have implemented FCTC compliant HWLs (p < 0.05). The countries with voluntary HWLs in 1992 were less likely (OR = 0.19, p < 0.01) to comply with FCTC 21 years later (in 2013). The FCTC has promoted HWL policies among LMICs. Public health regulations require investments in broader state capacity. As the theory of path-dependency predicts voluntary agreements have long lasting influence on the direction of tobacco control in a country. Adopting voluntary HWL policies reduced likelihood of having FCTC compliant HWLs decades later. The fact that voluntary agreements delayed effective tobacco regulations suggests that policymakers must be careful of accepting industry efforts for voluntary agreements in other areas of public health as well, such as alcohol and junk food. PMID:25462428

  15. Are heat warning systems effective?

    PubMed Central

    2013-01-01

    Heatwaves are associated with significant health risks particularly among vulnerable groups. To minimize these risks, heat warning systems have been implemented. The question therefore is how effective these systems are in saving lives and reducing heat-related harm. We systematically searched and reviewed 15 studies which examined this. Six studies asserted that fewer people died of excessive heat after the implementation of heat warning systems. Demand for ambulance decreased following the implementation of these systems. One study also estimated the costs of running heat warning systems at US$210,000 compared to the US$468 million benefits of saving 117 lives. The remaining eight studies investigated people’s response to heat warning systems and taking appropriate actions against heat harms. Perceived threat of heat dangers emerged as the main factor related to heeding the warnings and taking proper actions. However, barriers, such as costs of running air-conditioners, were of significant concern, particularly to the poor. The weight of the evidence suggests that heat warning systems are effective in reducing mortality and, potentially, morbidity. However, their effectiveness may be mediated by cognitive, emotive and socio-demographic characteristics. More research is urgently required into the cost-effectiveness of heat warning systems’ measures and improving the utilization of the services. PMID:23561265

  16. The Efficacy of Cigarette Warning Labels on Health Beliefs in the United States and Mexico

    PubMed Central

    MUTTI, SEEMA; HAMMOND, DAVID; REID, JESSICA L.; THRASHER, JAMES F.

    2013-01-01

    Concern over health risks is the most common motivation for quitting smoking. Health warnings on tobacco packages are among the most prominent interventions to convey the health risks of smoking. Face-to-face surveys were conducted in Mexico (n=1,072), and a web-based survey was conducted in the US (n=1,449) to examine the efficacy of health warning labels on health beliefs. Respondents were randomly assigned to view two sets of health warnings (each with one text-only warning and 5–6 pictorial warnings) for two different health effects. Respondents were asked whether they believed smoking caused 12 different health effects. Overall, the findings indicate high levels of health knowledge in both countries for some health effects, although significant knowledge gaps remained; for example: less than half of respondents agreed that smoking causes impotence and less than one third agreed that smoking causes gangrene. Mexican respondents endorsed a greater number of correct beliefs about the health impact of smoking than the US sample. In both countries, viewing related health warning labels increased beliefs about the health risks of smoking, particularly for less well-known health effects, such as gangrene, impotence, and stroke. PMID:23905611

  17. The Effect of Cancer Warning Statements on Alcohol Consumption Intentions

    ERIC Educational Resources Information Center

    Pettigrew, Simone; Jongenelis, Michelle I.; Glance, David; Chikritzhs, Tanya; Pratt, Iain S.; Slevin, Terry; Liang, Wenbin; Wakefield, Melanie

    2016-01-01

    In response to increasing calls to introduce warning labels on alcoholic beverages, this study investigated the potential effectiveness of alcohol warning statements designed to increase awareness of the alcohol-cancer link. A national online survey was administered to a diverse sample of Australian adult drinkers (n = 1,680). Along with…

  18. Can cigarette warnings counterbalance effects of smoking scenes in movies?

    PubMed

    Golmier, Isabelle; Chebat, Jean-Charles; Gélinas-Chebat, Claire

    2007-02-01

    Scenes in movies where smoking occurs have been empirically shown to influence teenagers to smoke cigarettes. The capacity of a Canadian warning label on cigarette packages to decrease the effects of smoking scenes in popular movies has been investigated. A 2 x 3 factorial design was used to test the effects of the same movie scene with or without electronic manipulation of all elements related to smoking, and cigarette pack warnings, i.e., no warning, text-only warning, and text+picture warning. Smoking-related stereotypes and intent to smoke of teenagers were measured. It was found that, in the absence of warning, and in the presence of smoking scenes, teenagers showed positive smoking-related stereotypes. However, these effects were not observed if the teenagers were first exposed to a picture and text warning. Also, smoking-related stereotypes mediated the relationship of the combined presentation of a text and picture warning and a smoking scene on teenagers' intent to smoke. Effectiveness of Canadian warning labels to prevent or to decrease cigarette smoking among teenagers is discussed, and areas of research are proposed. PMID:17450995

  19. 40 CFR 82.112 - Removal of label bearing warning statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Removal of label bearing warning... Substances § 82.112 Removal of label bearing warning statement. (a) Prohibition on removal. Except as... manufacturer of a product that incorporates a product that is accompanied by a label bearing the...

  20. 40 CFR 82.112 - Removal of label bearing warning statement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Removal of label bearing warning... Substances § 82.112 Removal of label bearing warning statement. (a) Prohibition on removal. Except as... manufacturer of a product that incorporates a product that is accompanied by a label bearing the...

  1. 40 CFR 82.112 - Removal of label bearing warning statement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Removal of label bearing warning... Substances § 82.112 Removal of label bearing warning statement. (a) Prohibition on removal. Except as... manufacturer of a product that incorporates a product that is accompanied by a label bearing the...

  2. 40 CFR 82.112 - Removal of label bearing warning statement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Removal of label bearing warning... Substances § 82.112 Removal of label bearing warning statement. (a) Prohibition on removal. Except as... manufacturer of a product that incorporates a product that is accompanied by a label bearing the...

  3. 40 CFR 82.112 - Removal of label bearing warning statement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Removal of label bearing warning... Substances § 82.112 Removal of label bearing warning statement. (a) Prohibition on removal. Except as... manufacturer of a product that incorporates a product that is accompanied by a label bearing the...

  4. 16 CFR 1205.6 - Warning label for reel-type and rotary power mowers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... adjacent supporting structure or assembly, with the warning label shown in Fig. 7. The label shall be at... size relation to each other and to the label as shown in Fig. 7. EC03OC91.016 (b) Rotary mowers. Walk-behind rotary mowers shall have one label as shown in Fig. 7, on the blade housing. The label shall...

  5. 16 CFR 1205.6 - Warning label for reel-type and rotary power mowers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... adjacent supporting structure or assembly, with the warning label shown in Fig. 7. The label shall be at... size relation to each other and to the label as shown in Fig. 7. EC03OC91.016 (b) Rotary mowers. Walk-behind rotary mowers shall have one label as shown in Fig. 7, on the blade housing. The label shall...

  6. Refining Prescription Warning Labels Using Patient Feedback: A Qualitative Study.

    PubMed

    Shiyanbola, Olayinka O; Smith, Paul D; Mansukhani, Sonal Ghura; Huang, Yen-Ming

    2016-01-01

    The complexity of written medication information hinders patients' understanding and leads to patient misuse of prescribed medications. Incorporating patient feedback in designing prescription warning labels (PWLs) is crucial in enhancing patient comprehension of medication warning instructions. This qualitative study explored patient feedback on five newly designed PWLs. In-depth semi-structured face-to-face interviews were conducted with 21 patients, who were 18 years and older, spoke English, and took a prescription medication. These patients were shown different variations of the five most commonly used PWLs-Take with Food, Do not Drink Alcohol, Take with a Full glass of Water, Do not Chew or Break, and Protect from Sunlight. The 60-minute interviews explored feedback on patient comprehension of the PWL instructions and their suggestions for improving the clarity of the PWLs. At the end of the interview, patient self-reported socio-demographic information was collected with a 3-minute survey and a brief health literacy assessment was completed using the Newest Vital Sign. Twenty-one patients completed the interviews. Most patients were female (n = 15, 71.4%) with ages ranging from 23 to 66 years old (mean: 47.6 ± 13.3). The mean health literacy score was 2.4 on a scale of 0-6. Qualitative content analysis based on the text, pictures, and placement of the PWLs on the pill bottle showed preferences for including 'WARNING' on the PWL to create alertness, inclusion of a picture together with the text, yellow color highlighting behind the text, and placement of the PWL on the front of the pill bottle. Although patients had positive opinions of the redesigned PWLs, patients wanted further improvements to the content and design of the PWLs for enhanced clarity and understandability. PMID:27258026

  7. Refining Prescription Warning Labels Using Patient Feedback: A Qualitative Study

    PubMed Central

    Mansukhani, Sonal Ghura; Huang, Yen-Ming

    2016-01-01

    The complexity of written medication information hinders patients’ understanding and leads to patient misuse of prescribed medications. Incorporating patient feedback in designing prescription warning labels (PWLs) is crucial in enhancing patient comprehension of medication warning instructions. This qualitative study explored patient feedback on five newly designed PWLs. In-depth semi-structured face-to-face interviews were conducted with 21 patients, who were 18 years and older, spoke English, and took a prescription medication. These patients were shown different variations of the five most commonly used PWLs-Take with Food, Do not Drink Alcohol, Take with a Full glass of Water, Do not Chew or Break, and Protect from Sunlight. The 60-minute interviews explored feedback on patient comprehension of the PWL instructions and their suggestions for improving the clarity of the PWLs. At the end of the interview, patient self-reported socio-demographic information was collected with a 3-minute survey and a brief health literacy assessment was completed using the Newest Vital Sign. Twenty-one patients completed the interviews. Most patients were female (n = 15, 71.4%) with ages ranging from 23 to 66 years old (mean: 47.6 ± 13.3). The mean health literacy score was 2.4 on a scale of 0–6. Qualitative content analysis based on the text, pictures, and placement of the PWLs on the pill bottle showed preferences for including ‘WARNING’ on the PWL to create alertness, inclusion of a picture together with the text, yellow color highlighting behind the text, and placement of the PWL on the front of the pill bottle. Although patients had positive opinions of the redesigned PWLs, patients wanted further improvements to the content and design of the PWLs for enhanced clarity and understandability. PMID:27258026

  8. Implications of Graphic Cigarette Warning Labels on Smoking Behavior: An International Perspective.

    PubMed

    Jung, Minsoo

    2016-03-01

    Graphic warning labels (GWLs) have been developed as a representative non-price policy to block such marketing. This study investigated the current state and effect of the global introduction of GWLs and examines the future tasks related to GWLs. We systematically reviewed literatures on GWL and a tobacco control strategy in the past fifteen years. The policy of enforcing GWLs has spread globally based on the Framework Convention on Tobacco Control. GWLs are more effective than text warnings and are implemented in over 70 countries. The policy has showed the impact of GWLs as a preventive effect on adolescents' smoking, inducement of smoking cessation, reduction in the amount of tobacco smoked, and reduction in smoking rates. The success of an anti-smoking policy can manifests itself as an effect of individual policies, the rise of tobacco prices, and the introduction of GWLs.

  9. Implications of Graphic Cigarette Warning Labels on Smoking Behavior: An International Perspective

    PubMed Central

    Jung, Minsoo

    2016-01-01

    Graphic warning labels (GWLs) have been developed as a representative non-price policy to block such marketing. This study investigated the current state and effect of the global introduction of GWLs and examines the future tasks related to GWLs. We systematically reviewed literatures on GWL and a tobacco control strategy in the past fifteen years. The policy of enforcing GWLs has spread globally based on the Framework Convention on Tobacco Control. GWLs are more effective than text warnings and are implemented in over 70 countries. The policy has showed the impact of GWLs as a preventive effect on adolescents’ smoking, inducement of smoking cessation, reduction in the amount of tobacco smoked, and reduction in smoking rates. The success of an anti-smoking policy can manifests itself as an effect of individual policies, the rise of tobacco prices, and the introduction of GWLs. PMID:27051645

  10. 40 CFR 82.110 - Form of label bearing warning statement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... matter on the label. The warning statement shall appear in sharp contrast to any background upon which it... contrast are: black letters on a dark blue or dark green background, dark red letters on a light red... warning statement shall be the standard chemical name of the substance as listed in 40 CFR part...

  11. 40 CFR 82.110 - Form of label bearing warning statement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... matter on the label. The warning statement shall appear in sharp contrast to any background upon which it... contrast are: black letters on a dark blue or dark green background, dark red letters on a light red... warning statement shall be the standard chemical name of the substance as listed in 40 CFR part...

  12. 40 CFR 82.110 - Form of label bearing warning statement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... matter on the label. The warning statement shall appear in sharp contrast to any background upon which it... contrast are: black letters on a dark blue or dark green background, dark red letters on a light red... warning statement shall be the standard chemical name of the substance as listed in 40 CFR part...

  13. 40 CFR 82.110 - Form of label bearing warning statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... matter on the label. The warning statement shall appear in sharp contrast to any background upon which it... contrast are: black letters on a dark blue or dark green background, dark red letters on a light red... warning statement shall be the standard chemical name of the substance as listed in 40 CFR part...

  14. 19 CFR 18.4 - Sealing conveyances and compartments; labeling packages; warning cards.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... affecting § 18.4, see the List of CFR Sections Affected, which appears in the Finding Aids section of the... packages; warning cards. 18.4 Section 18.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... Provisions § 18.4 Sealing conveyances and compartments; labeling packages; warning cards. (a)(1)...

  15. 19 CFR 18.4 - Sealing conveyances and compartments; labeling packages; warning cards.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... affecting § 18.4, see the List of CFR Sections Affected, which appears in the Finding Aids section of the... packages; warning cards. 18.4 Section 18.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... Provisions § 18.4 Sealing conveyances and compartments; labeling packages; warning cards. (a)(1)...

  16. 19 CFR 18.4 - Sealing conveyances and compartments; labeling packages; warning cards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... affecting § 18.4, see the List of CFR Sections Affected, which appears in the Finding Aids section of the... packages; warning cards. 18.4 Section 18.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... Provisions § 18.4 Sealing conveyances and compartments; labeling packages; warning cards. (a)(1)...

  17. 19 CFR 18.4 - Sealing conveyances and compartments; labeling packages; warning cards.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... affecting § 18.4, see the List of CFR Sections Affected, which appears in the Finding Aids section of the... packages; warning cards. 18.4 Section 18.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... Provisions § 18.4 Sealing conveyances and compartments; labeling packages; warning cards. (a)(1)...

  18. 16 CFR 1205.6 - Warning label for reel-type and rotary power mowers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SAFETY ACT REGULATIONS SAFETY STANDARD FOR WALK-BEHIND POWER LAWN MOWERS The Standard § 1205.6 Warning label for reel-type and rotary power mowers. (a) General. Walk-behind power lawn mowers shall be...

  19. Teaching Generalized Reading of Product Warning Labels to Young Adults with Autism Using the Constant Time Delay Procedure

    ERIC Educational Resources Information Center

    Dogoe, Maud S.; Banda, Devender R.; Lock, Robin H.; Feinstein, Rita

    2011-01-01

    This study examined the effectiveness of the constant timed delay procedure for teaching two young adults with autism to read, define, and state the contextual meaning of keywords on product warning labels of common household products. Training sessions were conducted in the dyad format using flash cards. Results indicated that both participants…

  20. Speaking out about physical harms from tobacco use: response to graphic warning labels among American Indian/Alaska Native communities

    PubMed Central

    Patterson Silver Wolf, David A; Tovar, Molly; Thompson, Kellie; Ishcomer, Jamie; Kreuter, Matthew W; Caburnay, Charlene; Boyum, Sonia

    2016-01-01

    Objective This study is the first to explore the impact of graphic cigarette labels with physical harm images on members of American Indian/Alaska Native (AI/AN) communities. The aim of this article is to investigate how AI/AN respond to particular graphic warning labels. Methods The parent study recruited smokers, at-risk smokers and non-smokers from three different age groups (youths aged 13–17 years, young adults aged 18–24 years and adults aged 25+ years) and five population subgroups with high smoking prevalence or smoking risk. Using nine graphic labels, this study collected participant data in the field via an iPad-administered survey and card sorting of graphic warning labels. This paper reports on findings for AI/AN participants. Results After viewing graphic warning labels, participants rated their likelihood of talking about smoking risks to friends, parents and siblings higher than their likelihood of talking to teachers and doctors. Further, this study found that certain labels (eg, the label of the toddler in the smoke cloud) made them think about their friends and family who smoke. Conclusions Given the influence of community social networks on health beliefs and attitudes, health communication using graphic warning labels could effect change in the smoking habits of AI/AN community members. Study findings suggest that graphic labels could serve as stimuli for conversations about the risks of smoking among AI/AN community members, and could be an important element of a peer-to-peer smoking cessation effort. PMID:27009143

  1. The effect of cancer warning statements on alcohol consumption intentions.

    PubMed

    Pettigrew, Simone; Jongenelis, Michelle I; Glance, David; Chikritzhs, Tanya; Pratt, Iain S; Slevin, Terry; Liang, Wenbin; Wakefield, Melanie

    2016-02-01

    In response to increasing calls to introduce warning labels on alcoholic beverages, this study investigated the potential effectiveness of alcohol warning statements designed to increase awareness of the alcohol-cancer link. A national online survey was administered to a diverse sample of Australian adult drinkers (n = 1,680). Along with attitudinal, intentions and demographic items, the survey included an online simulation that exposed respondents to one of six cancer warning statements delivered across a range of situational contexts. Half of the statements made general reference to cancer and half mentioned specific forms of cancer. Respondents reported on the believability, convincingness and personal relevance of the warning statements. Pre- and post-exposure data were captured relating to respondents' alcohol consumption intentions. Of the six statements tested, Alcohol increases your risk of bowel cancer produced the highest scores across all outcome measures. All statements produced favorable changes in alcohol consumption intentions, including among high-risk drinkers. There is thus the potential for these and similar statements to be used as a suite of rotating warning messages located on alcoholic beverage labels and applied in various public education contexts. PMID:26787351

  2. Estimating the impact of different cigarette package warning label policies: the auction method.

    PubMed

    Thrasher, James F; Rousu, Matthew C; Anaya-Ocampo, Rafael; Reynales-Shigematsu, Luz Myriam; Arillo-Santillán, Edna; Hernández-Avila, Mauricio

    2007-12-01

    The study estimated the reduction in demand associated with implementing cigarette package warning labels that contain imagery illustrating the consequences of smoking. The experimental auction method was used, wherein adult smokers in Mexico (n=89) placed separate bids on two packs of cigarettes: one with a text-only warning label and the other with a warning label that included text and a graphic image. Differences in the values attributed to each pack were assessed using t-tests and multivariate regression. The pack with the graphic image had a mean attributed value which was 17% lower ($3.21 pesos) than the pack with the text-only warning, and this difference remained statistically significant within subgroups defined by sociodemographics, amount of smoking, number of quit attempts, and levels of perceived smoking risks. In the multivariate model, the difference in attributed values was greater among females than males, but no such differences were found for other sociodemographic or smoking-related variables. The consistently lower value that smokers attributed to cigarette packages with the graphic warning label indicates that these labels are likely to reduce cigarette demand. PMID:17630221

  3. Impact of Tobacco-Related Health Warning Labels across Socioeconomic, Race and Ethnic Groups: Results from a Randomized Web-Based Experiment

    PubMed Central

    Cantrell, Jennifer; Vallone, Donna M.; Thrasher, James F.; Nagler, Rebekah H.; Feirman, Shari P.; Muenz, Larry R.; He, David Y.; Viswanath, Kasisomayajula

    2013-01-01

    Background The U.S. Family Smoking Prevention and Tobacco Control Act of 2009 requires updating of the existing text-only health warning labels on tobacco packaging with nine new warning statements accompanied by pictorial images. Survey and experimental research in the U.S. and other countries supports the effectiveness of pictorial health warning labels compared with text-only warnings for informing smokers about the risks of smoking and encouraging cessation. Yet very little research has examined differences in reactions to warning labels by race/ethnicity, education or income despite evidence that population subgroups may differ in their ability to process health information. The purpose of the present study was to evaluate the potential impact of pictorial warning labels compared with text-only labels among U.S. adult smokers from diverse racial/ethnic and socioeconomic subgroups. Methods/Findings Participants were adult smokers recruited from two online research panels (n = 3,371) into a web-based experimental study to view either the new pictorial warnings or text-only warnings. Participants viewed the labels and reported their reactions. Adjusted regression models demonstrated significantly stronger reactions for the pictorial condition for each outcome salience (b = 0.62, p<.001); perceived impact (b = 0.44, p<.001); credibility (OR = 1.41, 95% CI = 1.22−1.62), and intention to quit (OR = 1.30, 95% CI = 1.10−1.53). No significant results were found for interactions between condition and race/ethnicity, education, or income. The only exception concerned the intention to quit outcome, where the condition-by-education interaction was nearly significant (p = 0.057). Conclusions Findings suggest that the greater impact of the pictorial warning label compared to the text-only warning is consistent across diverse racial/ethnic and socioeconomic populations. Given their great reach, pictorial health warning labels may be one of

  4. Experimental context modulates warning signal effects.

    PubMed

    Machado-Pinheiro, W; Faria, A J P; Gawryszewski, L G; Ribeiro-do-Valle, L E

    2004-07-01

    Previous studies have shown that saccadic eye responses but not manual responses were sensitive to the kind of warning signal used, with visual onsets producing longer saccadic latencies compared to visual offsets. The aim of the present study was to determine the effects of distinct warning signals on manual latencies and to test the premise that the onset interference, in fact, does not occur for manual responses. A second objective was to determine if the magnitude of the warning effects could be modulated by contextual procedures. Three experimental conditions based on the kind of warning signal used (visual onset, visual offset and auditory warning) were run in two different contexts (blocked and non-blocked). Eighteen participants were asked to respond to the imperative stimulus that would occur some milliseconds (0, 250, 500 or 750 ms) after the warning signal. The experiment consisted in three experimental sessions of 240 trials, where all the variables were counterbalanced. The data showed that visual onsets produced longer manual latencies than visual offsets in the non-blocked context (275 vs 261 ms; P < 0.001). This interference was obtained, however, only for short intervals between the warning and the stimulus, and was abolished when the blocked context was used (256 vs 255 ms; P = 0.789). These results are discussed in terms of bottom-up and top-down interactions, mainly those related to the role of attentional processing in cancelling out competitive interactions and suppressive influences of a distractor on the relevant stimulus.

  5. Nutritional information and health warnings on wine labels: Exploring consumer interest and preferences.

    PubMed

    Annunziata, A; Pomarici, E; Vecchio, R; Mariani, A

    2016-11-01

    This paper aims to contribute to the current debate on the inclusion of nutritional information and health warnings on wine labels, exploring consumers' interest and preferences. The results of a survey conducted on a sample of Italian wine consumers (N = 300) show the strong interest of respondents in the inclusion of such information on the label. Conjoint analysis reveals that consumers assign greater utility to health warnings, followed by nutritional information. Cluster analysis shows the existence of three different consumer segments. The first cluster, which included mainly female consumers (over 55) and those with high wine involvement, revealed greater awareness of the links between wine and health and better knowledge of wine nutritional properties, preferring a more detailed nutritional label, such as a panel with GDA%. By contrast, the other two clusters, consisting of individuals who generally find it more difficult to understand nutritional labels, preferred the less detailed label of a glass showing calories. The second and largest cluster comprising mainly younger men (under 44), showed the highest interest in health warnings while the third cluster - with a relatively low level of education - preferred the specification of the number of glasses not to exceed. Our results support the idea that the policy maker should consider introducing a mandatory nutritional label in the easier-to-implement and not-too-costly form of a glass with calories, rotating health warnings and the maximum number of glasses not to exceed.

  6. Does Reactance against Cigarette Warning Labels Matter? Warning Label Responses and Downstream Smoking Cessation amongst Adult Smokers in Australia, Canada, Mexico and the United States

    PubMed Central

    Cho, Yoo Jin; Thrasher, James F.; Swayampakala, Kamala; Yong, Hua-Hie; McKeever, Robert; Hammond, David; Anshari, Dien; Cummings, K. Michael; Borland, Ron

    2016-01-01

    Objective Some researchers have raised concerns that pictorial health warning labels (HWLs) on cigarette packages may lead to message rejection and reduced effectiveness of HWL messages. This study aimed to determine how state reactance (i.e., negative affect due to perceived manipulation) in response to both pictorial and text-only HWLs is associated with other types of HWL responses and with subsequent cessation attempts. Methods Survey data were collected every 4 months between September 2013 and 2014 from online panels of adult smokers in Australia, Canada, Mexico, and the US were analyzed. Participants with at least one wave of follow-up were included in the analysis (n = 4,072 smokers; 7,459 observations). Surveys assessed psychological and behavioral responses to HWLs (i.e., attention to HWLs, cognitive elaboration of risks due to HWLs, avoiding HWLs, and forgoing cigarettes because of HWLs) and cessation attempts. Participants then viewed specific HWLs from their countries and were queried about affective state reactance. Logistic and linear Generalized Estimating Equation (GEE) models regressed each of the psychological and behavioral HWL responses on reactance, while controlling for socio-demographic and smoking-related variables. Logistic GEE models also regressed having attempted to quit by the subsequent survey on reactance, each of the psychological and behavioral HWL responses (analyzed separately), adjustment variables. Data from all countries were initially pooled, with interactions between country and reactance assessed; when interactions were statistically significant, country-stratified models were estimated. Results Interactions between country and reactance were found in all models that regressed psychological and behavioral HWL responses on study variables. In the US, stronger reactance was associated with more frequent reading of HWLs and thinking about health risks. Smokers from all four countries with stronger reactance reported greater

  7. Can pictorial warning labels on cigarette packages address smoking-related health disparities?: Field experiments in Mexico to assess warning label content

    PubMed Central

    Thrasher, James F.; Arillo-Santillán, Edna; Villalobos, Victor; Pérez-Hernández, Rosaura; Hammond, David; Carter, Jarvis; Sebrié, Ernesto; Sansores, Raul; Regalado-Piñeda, Justino

    2012-01-01

    Objective This study aimed to determine the most effective content of pictorial health warning labels (HWLs) and whether educational attainment moderates these effects. Methods Field experiments were conducted with 529 adult smokers and 530 young adults (258 nonsmokers; 271 smokers), wherein participants reported responses to different HWLs printed on cigarette packages. One experiment involved manipulating textual form (testimonial narrative vs didactic) and the other involved manipulating imagery type (diseased organs vs human suffering). Results Tests of mean ratings and rankings indicated that HWLs with didactic textual forms had equivalent or significantly higher credibility, relevance, and impact than HWLs with testimonial forms. Results from mixed-effects models confirmed these results. However, responses differed by participant educational attainment: didactic forms were consistently rated higher than testimonials among participants with higher education, whereas the difference between didactic and testimonial narrative forms was weaker or not statistically significant among participants with lower education. In the second experiment, with textual content held constant, greater credibility, relevance and impact was found for graphic imagery of diseased organs than imagery of human suffering. Conclusions Pictorial HWLs with didactic textual forms appear to work better than with testimonial narratives. Future research should determine which pictorial HWL content has the greatest real-world impact among consumers from disadvantaged groups, including assessment of how HWL content should change to maintain its impact as tobacco control environments strengthen and consumer awareness of smoking-related risks increases. PMID:22350859

  8. Assessing the Consequences of Implementing Graphic Warning Labels on Cigarette Packs for Tobacco-Related Health Disparities

    PubMed Central

    Brennan, Emily; Momjian, Ani; Shapiro-Luft, Dina; Seitz, Holli; Cappella, Joseph N.

    2015-01-01

    Introduction: Population-level communication interventions, such as graphic warning labels (GWLs) on cigarette packs, have the potential to reduce or exacerbate tobacco-related health disparities depending on their effectiveness among disadvantaged sub-populations. This study evaluated the likely impact of nine GWLs proposed by the US Food and Drug Administration on (1) African American and (2) Hispanic smokers, who disproportionately bear the burden of tobacco-related illness, and (3) low education smokers, who have higher smoking rates. Methods: Data were collected online from current smokers randomly assigned to see GWLs (treatment) or the current text-only warning labels (control). Participants were stratified by age (18–25; 26+) in each of four groups: general population (n = 1246), African Americans (n = 1200), Hispanics (n = 1200), and low education (n = 1790). We tested the effectiveness of GWLs compared to text-only warning labels using eight outcomes that are predictive of quitting intentions or behaviors including negative emotion, intentions to hold back from smoking, intentions to engage in avoidance behaviors, and intentions to quit. Results: Across all outcomes, GWLs were significantly more effective than text-only warning labels more often than expected by chance. Results suggested that African Americans, Hispanics and smokers with low education did not differ from the general population of smokers in their reactions to any of the nine individual GWLs. Conclusions: The nine GWLs were similarly effective for disadvantaged sub-populations and the general population of smokers. Implementation of GWLs is therefore unlikely to reduce or exacerbate existing tobacco-related health disparities, but will most likely uniformly increase intentions and behaviors predictive of smoking cessation. PMID:26180214

  9. Children's misunderstandings of hazard warning signs in the new globally harmonized system for classification and labeling.

    PubMed

    Latham, Garry; Long, Tony; Devitt, Patric

    2013-12-01

    Accidental chemical poisoning causes more than 35 000 child deaths every year across the world, and it leads to disease, disability, and suffering for many more children. Children's ignorance of dangers and their failure to interpret hazard warning signs as intended contribute significantly to this problem. A new Globally Harmonized System for Classification and Labeling is being implemented internationally with a view to unifying the current multiple and disparate national systems. This study was designed to establish a productive, effective means of teaching the new GHS warning signs to primary school children (aged 7-11 years). A pre-test, post-test, follow-up test design was employed, with a teaching intervention informed by a Delphi survey of expert opinion. Children from one school formed the experimental group (n = 49) and a second school provided a control group (n = 23). Both groups showed a gain in knowledge from pre-test to post-test, the experimental group with a larger gain but which was not statistically significant. However, longer-term retention of knowledge, as shown by the follow-up test, was statistically significantly greater in the experimental group (p = 0.001). The employment of teaching to match children's preferred learning styles, and the use of active learning were found to be related to improved retention of knowledge. Part of the study involved eliciting children's interpretation of standard hazard warning symbols, and this provoked considerable concern over the potential for dangerous misinterpretation with disastrous consequences. This article focuses on the reasons for such misconception and the action required to address this successfully in testing the intervention. PMID:23964825

  10. 40 CFR 82.110 - Form of label bearing warning statement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... matter on the label. The warning statement shall appear in sharp contrast to any background upon which it... contrast are: black letters on a dark blue or dark green background, dark red letters on a light red background, light red letters on a reflective silver background, and white letters on a light gray or...

  11. Ethical and Practical Considerations in Removing Black Box Warnings from Drug Labels.

    PubMed

    Yeh, James S; Sarpatwari, Ameet; Kesselheim, Aaron S

    2016-08-01

    Boxed warnings-also known as "black box" warnings-can be a powerful tool in communicating drug risks to physicians and patients. The overall number of boxed warnings has grown in recent years as the US Food and Drug Administration (FDA) has approved more drugs on the basis of limited pre-marketing information and as new safety issues for marketed drugs have been identified. Two recent manufacturers' petitions to remove boxed warnings on the drugs rosiglitazone (Avandia) and varenicline (Chantix) have led to divergent FDA decisions and revealed different considerations involved in boxed warning imposition and removal. For ethical and practical reasons, the FDA is justified in applying a higher standard for boxed warning removal than for imposition, as removal of a boxed warning may have unintended effects on physician and patient behavior. However, no guidelines on boxed warning removal currently exist. To promote safe use of approved prescription drugs, the FDA should adopt a uniform and transparent process governing decisions to impose or remove boxed warnings. PMID:27000800

  12. The Unintended Effects of a Boxed Warning

    PubMed Central

    Eisenthal, Andrew

    2009-01-01

    Objective: To demonstrate a real-life correlation that after the US Food and Drug Administration introduced a boxed warning concerning malignancies to the labeling for topical calcineurin inhibitors, reluctance to use topical calcineurin inhibitors has led to their substitution with other therapies that have their own risks. Participants: An anonymous survey of attendees of the 2007 Fall Clinical Dermatology conference in Las Vegas, Nevada, from October 17–19, 2007. More than 95 percent of attendees were dermatologists; a small number of mid-level practitioners attended as well. Of nearly 700 attendees, the first 504 who agreed to complete the survey were included. Results: More than 40 percent of dermatologists surveyed claimed that more than 20 percent of their atopic dermatitis patients are not adequately controlled since the introduction of the boxed warning. Forty-eight percent claim that more than 20 percent of those patients were adequately controlled with topical calcineurin inhibitors as part of their regimens. Eighty percent of dermatologists surveyed agree that more than 10 precent of those patients were adequately controlled with topical calcineurin inhibitors in their regimens. Conclusion: While caution is usually prudent, the introduction of a boxed warning in the case of topical calcineurin inhibitors has led to the use of treatments that often have greater risks than the topical calcineurin inhibitors that they replaced. PMID:20729957

  13. Framing Pictorial Cigarette Warning Labels to Motivate Young Smokers to Quit

    PubMed Central

    Turner, Monique M.; Zhao, Xiaoquan; Evans, W. Douglas; Luta, George; Tercyak, Kenneth P.

    2015-01-01

    Introduction: The Family Smoking Prevention and Tobacco Control Act requires new pictorial warnings for U.S. cigarette packs, but enactment has been delayed by tobacco industry lawsuits. Research can inform implementation of the pictorial warning requirement and identify ways to optimize their public health impact post-implementation. This study investigated the impact of warning label message framing on young smokers’ motivation to quit, examining cessation self-efficacy, and perceived risks as moderators of message framing impact. Methods: Smokers ages 18–30 (n = 740) completed baseline measures and were randomized to view 4 images of cigarette packs with pictorial health warnings featuring gain- or loss-framed messages. Motivation to quit was assessed after participants viewed the pack images. Linear models accounting for repeated measures and adjusting for baseline covariates examined the impact of message framing and interactions with baseline self-efficacy to quit and perceived risks of smoking. Results: Loss-framed warnings prompted significantly greater motivation to quit among smokers with high self-efficacy compared with smokers with low self-efficacy. Among smokers with low self-efficacy, gain-framed messages were superior to loss-framed messages. Gain-framed warnings generated significantly greater motivation to quit among smokers with high perceived risks compared with smokers with low perceived risks. Among smokers with high perceived risks, gain-framed messages were superior to loss-framed messages. Conclusions: A combination of pictorial warnings featuring risk-based (i.e., loss-framed) and efficacy-enhancing (i.e., gain-framed) information may promote better public health outcomes. Research is needed to investigate how strategically framed warning messages impact smokers’ behaviors based on their pre-existing attitudes and beliefs in real-world settings. PMID:25143295

  14. Cancer illustrations and warning labels on cigarette packs: perceptions of teenagers from high socioeconomic status in Lahore.

    PubMed

    Zil-E-Ali, Ahsan; Ahsen, Noor Fatima; Iqbal, Humaira

    2015-06-01

    Smoking is linked with adverse health outcomes and multi-organ diseases with six million deaths every year. The smoking population includes both genders and the habit is seen in minors as well. The cross-sectional study was conducted in Lahore among teenagers belonging to high socioeconomic class. A sample of 191 students was recruited by convenience sampling. The teenagers were questioned on their perceptions relating to prohibition labels, factors that led them to smoke, and ideas to make health warnings more effective. Overall, 66(34.55%) teenagers were smokers, and of them, 50(75.75%) were boys and 16(24.24%) were girls. Besides, 25(37.9%) smokers were of the view that smoking is a bad habit; 40(60.6%) said prohibition labels would not change the mindset of the smoker; 35(53%)believed that a smoker is completely uninfluenced by prohibition labels. Results suggest that the warning labels on cigarette packs should be made more comprehensible and alarming for smokers.

  15. Cancer illustrations and warning labels on cigarette packs: perceptions of teenagers from high socioeconomic status in Lahore.

    PubMed

    Zil-E-Ali, Ahsan; Ahsen, Noor Fatima; Iqbal, Humaira

    2015-06-01

    Smoking is linked with adverse health outcomes and multi-organ diseases with six million deaths every year. The smoking population includes both genders and the habit is seen in minors as well. The cross-sectional study was conducted in Lahore among teenagers belonging to high socioeconomic class. A sample of 191 students was recruited by convenience sampling. The teenagers were questioned on their perceptions relating to prohibition labels, factors that led them to smoke, and ideas to make health warnings more effective. Overall, 66(34.55%) teenagers were smokers, and of them, 50(75.75%) were boys and 16(24.24%) were girls. Besides, 25(37.9%) smokers were of the view that smoking is a bad habit; 40(60.6%) said prohibition labels would not change the mindset of the smoker; 35(53%)believed that a smoker is completely uninfluenced by prohibition labels. Results suggest that the warning labels on cigarette packs should be made more comprehensible and alarming for smokers. PMID:26060175

  16. The Impact of Cigarette Pack Design, Descriptors, and Warning Labels on Risk Perception in the U.S

    PubMed Central

    Bansal-Travers, Maansi; Hammond, David; Smith, Philip; Cummings, K. Michael

    2011-01-01

    Background In the U.S., limited evidence exists on the impact of colors and brand imagery used in cigarette pack design. Purpose This study examined the impact of pack design, product descriptors, and health warnings on risk perception and brand appeal. Methods A cross-sectional mall-intercept study was conducted with 197 adult smokers and 200 nonsmokers in Buffalo, NY from June to July 2009 (data analysis from July 2009 to December 2010). Participants were shown 12 sets of packs randomly; each set varied by a particular design feature (color, descriptor) or warning label style (text vs graphic, size, attribution, message framing). Packs were rated on criteria including risk perceptions, quit motivation, and purchase interest. Results Participants selected larger, pictorial, and loss-framed warning labels as more likely to attract attention, encourage thoughts about health risks, motivate quitting, and most effective. Participants were more likely to select packs with lighter color shading and descriptors such as light, silver, and smooth as delivering less tar, smoother taste, and lower health risk, compared to darker-shaded or full flavor packs. Additionally, participants were more likely to select the branded compared to plain white pack when asked which delivered the most tar, smoothest taste, was more attractive, appealed to youth aged <18 years, and contained cigarettes of better quality. Conclusions The findings support larger, graphic health warnings that convey loss-framed messages as most effective in communicating health risks to U.S. adults. The results also indicate that color and product descriptors are associated with false beliefs about risks. Plain packaging may reduce many of the erroneous misperceptions of risk communicated through pack design features. PMID:21565661

  17. Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues

    PubMed Central

    Wang, An-Li; Romer, Dan; Elman, Igor; Turetsky, Bruce I.; Gur, Ruben C.; Langleben, Daniel D.

    2015-01-01

    There is an ongoing public debate about the new graphic warning labels (GWLs) that the Food and Drug Administration (FDA) proposes to place on cigarette packs. Tobacco companies argued that the strongly emotional images FDA proposed to include in the GWLs encroached on their constitutional rights. The court ruled that FDA did not provide sufficient scientific evidence of compelling public interest in such encroachment. This study’s objectives were to examine the effects of the GWLs on the electrophysiological and behavioral correlates of smoking addiction and to determine whether labels rated higher on the emotional reaction (ER) scale are associated with greater effects. We studied 25 non-treatment-seeking smokers. Event-related potentials (ERPs) were recorded while participants viewed a random sequence of paired images, in which visual smoking (Cues) or non-smoking (non-Cues) images were preceded by GWLs or neutral images. Participants reported their cigarette craving after viewing each pair. Dependent variables were magnitude of P300 ERPs and self-reported cigarette craving in response to Cues. We found that subjective craving response to Cues was significantly reduced by preceding GWLs, whereas the P300 amplitude response to Cues was reduced only by preceding GWLs rated high on the ER scale. In conclusion, our study provides experimental neuroscience evidence that weighs in on the ongoing public and legal debate about how to balance the constitutional and public health aspects of the FDA-proposed GWLs. The high toll of smoking-related illness and death adds urgency to the debate and prompts consideration of our findings while longitudinal studies of GWLs are underway. PMID:24330194

  18. Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues.

    PubMed

    Wang, An-Li; Romer, Dan; Elman, Igor; Turetsky, Bruce I; Gur, Ruben C; Langleben, Daniel D

    2015-03-01

    There is an ongoing public debate about the new graphic warning labels (GWLs) that the Food and Drug Administration (FDA) proposes to place on cigarette packs. Tobacco companies argued that the strongly emotional images FDA proposed to include in the GWLs encroached on their constitutional rights. The court ruled that FDA did not provide sufficient scientific evidence of compelling public interest in such encroachment. This study's objectives were to examine the effects of the GWLs on the electrophysiological and behavioral correlates of smoking addiction and to determine whether labels rated higher on the emotional reaction (ER) scale are associated with greater effects. We studied 25 non-treatment-seeking smokers. Event-related potentials (ERPs) were recorded while participants viewed a random sequence of paired images, in which visual smoking (Cues) or non-smoking (non-Cues) images were preceded by GWLs or neutral images. Participants reported their cigarette craving after viewing each pair. Dependent variables were magnitude of P300 ERPs and self-reported cigarette craving in response to Cues. We found that subjective craving response to Cues was significantly reduced by preceding GWLs, whereas the P300 amplitude response to Cues was reduced only by preceding GWLs rated high on the ER scale. In conclusion, our study provides experimental neuroscience evidence that weighs in on the ongoing public and legal debate about how to balance the constitutional and public health aspects of the FDA-proposed GWLs. The high toll of smoking-related illness and death adds urgency to the debate and prompts consideration of our findings while longitudinal studies of GWLs are underway. PMID:24330194

  19. Neural response to pictorial health warning labels can predict smoking behavioral change

    PubMed Central

    Riddle, Philip J.; Newman-Norlund, Roger D.; Baer, Jessica; Thrasher, James F.

    2016-01-01

    In order to improve our understanding of how pictorial health warning labels (HWLs) influence smoking behavior, we examined whether brain activity helps to explain smoking behavior above and beyond self-reported effectiveness of HWLs. We measured the neural response in the ventromedial prefrontal cortex (vmPFC) and the amygdala while adult smokers viewed HWLs. Two weeks later, participants’ self-reported smoking behavior and biomarkers of smoking behavior were reassessed. We compared multiple models predicting change in self-reported smoking behavior (cigarettes per day [CPD]) and change in a biomarkers of smoke exposure (expired carbon monoxide [CO]). Brain activity in the vmPFC and amygdala not only predicted changes in CO, but also accounted for outcome variance above and beyond self-report data. Neural data were most useful in predicting behavioral change as quantified by the objective biomarker (CO). This pattern of activity was significantly modulated by individuals’ intention to quit. The finding that both cognitive (vmPFC) and affective (amygdala) brain areas contributed to these models supports the idea that smokers respond to HWLs in a cognitive-affective manner. Based on our findings, researchers may wish to consider using neural data from both cognitive and affective networks when attempting to predict behavioral change in certain populations (e.g. cigarette smokers). PMID:27405615

  20. Summaries of Safety Labeling Changes Approved by the FDA: Boxed Warnings Highlights.

    PubMed

    Rose, Brenda

    2016-06-01

    As part of the US Food and Drug Administration's MedWatch program, safety labeling changes are reviewed and compiled monthly for drugs and therapeutic biologics where important changes have been made to the safety information. Boxed warnings (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm075096.pdf) are ordinarily used to highlight either adverse reactions so serious in proportion to the potential benefit from the drug that it is essential that it be considered in assessing the risks and benefits of using the drugs or serious adverse reactions that can be prevented/reduced in frequency or severity by appropriate use of the drug; or FDA approved the drug with restrictions to ensure safe use because FDA concluded that the drug can be safely used only if distribution or use is restricted. There were 4 revised boxed warning from January through March 2016.

  1. Summaries of Safety Labeling Changes Approved by the FDA: Boxed Warnings Highlights.

    PubMed

    Rose, Brenda

    2016-06-01

    As part of the US Food and Drug Administration's MedWatch program, safety labeling changes are reviewed and compiled monthly for drugs and therapeutic biologics where important changes have been made to the safety information. Boxed warnings (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm075096.pdf) are ordinarily used to highlight either adverse reactions so serious in proportion to the potential benefit from the drug that it is essential that it be considered in assessing the risks and benefits of using the drugs or serious adverse reactions that can be prevented/reduced in frequency or severity by appropriate use of the drug; or FDA approved the drug with restrictions to ensure safe use because FDA concluded that the drug can be safely used only if distribution or use is restricted. There were 4 revised boxed warning from January through March 2016. PMID:27354752

  2. Compelled commercial speech: the Food and Drug Administration's effort to smoke out the tobacco industry through graphic warning labels.

    PubMed

    Haynes, Bryan M; Andrews, Anne Hampton; Jacob, C Reade

    2013-01-01

    FDA's proposed graphic warning labels for cigarette packages have been scrutinized for potentially violating the First Amendment's free speech clause. This article addresses the distinction between the commercial speech and compelled speech doctrines and their applicability in analyzing the constitutionality of the labels. The government's position is that the labels evoke an emotional response and educate consumers, while tobacco companies argue that the labels forcibly promote the government's message. Two federal appellate courts, applying different legal standards, have arrived at different conclusions. This article advocates that the Supreme Court, if faced with review of the labels, should apply strict scrutiny and declare the labels unconstitutional. PMID:24552078

  3. Disclaimer labels on fashion magazine advertisements: effects on social comparison and body dissatisfaction.

    PubMed

    Tiggemann, Marika; Slater, Amy; Bury, Belinda; Hawkins, Kimberley; Firth, Bonny

    2013-01-01

    Recent proposals across a number of Western countries have suggested that idealised media images should carry some sort of disclaimer informing readers when these images have been digitally enhanced. The present studies aimed to experimentally investigate the impact on women's body dissatisfaction of the addition of such warning labels to fashion magazine advertisements. Participants were 120 and 114 female undergraduate students in Experiment 1 and Experiment 2 respectively. In both experiments, participants viewed fashion magazine advertisements with either no warning label, a generic warning label, or a specific more detailed warning label. In neither experiment was there a significant effect of type of label. However, state appearance comparison was found to predict change in body dissatisfaction irrespective of condition. Unexpectedly, trait appearance comparison moderated the effect of label on body dissatisfaction, such that for women high on trait appearance comparison, exposure to specific warning labels actually resulted in increased body dissatisfaction. In sum, the present results showed no benefit of warning labels in ameliorating the known negative effect of viewing thin-ideal media images, and even suggested that one form of warning (specific) might be harmful for some individuals. Accordingly, it was concluded that more extensive research is required to guide the most effective use of disclaimer labels. PMID:22947622

  4. Teaching Generalized Reading of Product Warning Labels to Adolescents with Mental Disabilities through the Use of Key Words.

    ERIC Educational Resources Information Center

    Collins, Belva C.; Stinson, Dawn M.

    1995-01-01

    Key words from product warning labels were taught to four adolescents with moderate mental disabilities using flash cards and a progressive time-delay procedure. Although students mastered the words in a relatively short time with minimal errors, generalization probe data with actual products across settings revealed the need for instruction to…

  5. 16 CFR 316.4 - Requirement to place warning labels on commercial electronic mail that contains sexually oriented...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... commercial electronic mail that contains sexually oriented material. 316.4 Section 316.4 Commercial Practices... place warning labels on commercial electronic mail that contains sexually oriented material. (a) Any person who initiates, to a protected computer, the transmission of a commercial electronic mail...

  6. Pictorial Health Warning Label Content and Smokers' Understanding of Smoking-Related Risks--A Cross-Country Comparison

    ERIC Educational Resources Information Center

    Swayampakala, Kamala; Thrasher, James F.; Hammond, David; Yong, Hua-Hie; Bansal-Travers, Maansi; Krugman, Dean; Brown, Abraham; Borland, Ron; Hardin, James

    2015-01-01

    The aim of the present study was to assess smokers' level of agreement with smoking-related risks and toxic tobacco constituents relative to inclusion of these topics on health warning labels (HWLs). 1000 adult smokers were interviewed between 2012 and 2013 from online consumer panels of adult smokers from each of the three countries: Australia…

  7. Novelty effects in a multimodal warning signal.

    PubMed

    Rowe; Guilford

    1999-02-01

    The warning signals of toxic insects are often 'multimodal', combining bright coloration with sounds or odours (or both). Pyrazine (a common insect warning odour) can elicit an intrinsic avoidance in domestic chicks Gallus gallus domesticus, both against novel coloured food, and also against food colours that are specifically associated with aposematism, namely yellow and red. In three experiments, we investigated the role of novelty in this innate bias against yellow coloured food in the presence of pyrazine. Naive chicks were familiarized either to pyrazine odour or to coloured food before being tested for a bias against yellow (warningly coloured) food as opposed to green (nonwarningly coloured) food. In experiment 1, pyrazine novelty was shown to be vital for eliciting a bias against yellow food. However, experiment 2 suggested that colour novelty was not important: chicks familiarized with coloured crumbs still avoided yellow crumbs when pyrazine was presented. In a third experiment that gave chicks an even greater degree of pre-exposure to coloured crumbs, the bias against yellow food eventually waned, although pyrazine continued to elicit an aversion to yellow even after birds had had experience of up to 24 palatable yellow crumbs. Pyrazine novelty has been an important pressure in the evolution of multimodal warning signals, and can continue to promote the avoidance of warningly coloured food, even when it is relatively familiar. The implications for warning signals are discussed. Copyright 1999 The Association for the Study of Animal Behaviour.

  8. Quantitative assessment of the effectiveness of a rockfall warning system

    NASA Astrophysics Data System (ADS)

    Bründl, Michael; Sättele, Martina; Krautblatter, Michael; Straub, Daniel

    2016-04-01

    Rockslides and rockfalls can pose high risk to human settlements and traffic infrastructure. In addition to structural mitigation measures like rockfall nets, warning systems are increasingly installed to reduce rockfall risks. Whereas for structural mitigation measures with reducing effects on the spatial extent a structured evaluation method is existing, no or only few approaches to assess the effectiveness for warning systems are known. Especially for higher magnitude rockfalls structural mitigation measures are not effective, and reliable early warning systems will be essential in future. In response to that, we developed a classification and a framework to assess the reliability and effectiveness of early warning systems (Sättele et al, 2015a; 2016). Here, we demonstrate an application for the rockfall warning system installed in Preonzo prior to a major rockfall in May 2012 (Sättele et al., 2015b). We show that it is necessary to design such a warning system as fail-safe construction, which has to incorporate components with low failure probabilities, high redundancy, low warning thresholds, and additional control systems. With a hypothetical probabilistic analysis, we investigate the effect of the risk attitude of decision makers and of the number of sensors on the probability of detecting an event and on initiating a timely evacuation, as well as on related intervention cost. We conclude that it is possible to quantitatively assess the effectiveness of warning systems, which helps to optimize mitigation strategies against rockfall events. References Sättele, M., Bründl, M., and Straub, D.: Reliability and effectiveness of warning systems for natural hazards: concept and application to debris flow warning, Rel. Eng. Syst. Safety, 142, 192-202, 2015a. Sättele, M., Krautblatter, M., Bründl, M., and Straub, D.: Forecasting rock slope failure: How reliable and effective are warning systems?, Landslides, 605, 1-14, 2015b. Sättele, M., Bründl, M., and

  9. Thermoregulation constrains effective warning signal expression.

    PubMed

    Lindstedt, Carita; Lindström, Leena; Mappes, Johanna

    2009-02-01

    Evolution of conspicuous signals may be constrained if animal coloration has nonsignaling as well as signaling functions. In aposematic wood tiger moth (Parasemia plantaginis) larvae, the size of a warning signal (orange patch on black body) varies phenotypically and genetically. Although a large warning signal is favored as an antipredator defense, we hypothesized that thermoregulation may constrain the signal size in colder habitats. To test this hypothesis, we conducted a factorial rearing experiment with two selection lines for larval coloration (small and large signal) and with two temperature manipulations (high and low temperature environment). Temperature constrained the size and brightness of the warning signal. Larvae with a small signal had an advantage in the colder environment, which was demonstrated by a faster development time and growth rate in the low temperature treatment, compared to larvae with a large signal. Interestingly, the larvae with a small signal were found more often on the plant than the ones with a large signal, suggesting higher basking activity of the melanic (small signal) individuals in the low temperature. We conclude that the expression of aposematic display is not only defined by its efficacy against predators; variation in temperature may constrain evolution of a conspicuous warning signal and maintain variation in it.

  10. Is the Effectiveness of Tobacco Image-Based Warning Labels Likely to Vary by Socio-Demographic Variable? Findings from an Online Survey of 19,000 Members of the UK Public

    ERIC Educational Resources Information Center

    Styles, Maggie; Williams, Brian; Humphris, Gerry

    2013-01-01

    Objective: Smoking continues to be a major global cause of mortality and morbidity. Countries have increasingly adopted the use of images as warnings on cigarette packs. We aimed to investigate the likely differential impact of varied images and messages on sub-groups of the United Kingdom (UK) smoking population. Methods: Forty two images…

  11. The Case for Requiring Graphic Warning Labels on Smokeless Tobacco Product Packages.

    PubMed

    Pakhale, Smita; Samet, Jonathan; Folan, Patricia; Leone, Frank; White, Alexander

    2016-03-01

    On November 10, 2015, the U.S. Food and Drug Administration approved, for the first time, the sale of smokeless tobacco products authorized under the new premarket tobacco application pathway. This Food and Drug Administration regulatory decision draws attention to the growing worldwide use of smokeless tobacco products in general. Use of these tobacco products is particularly popular in low- and middle-income countries of Asia. Due to aggressive and strategic marketing to children, young adults, and current smokers, rates of smokeless tobacco use in men of all ages are on the rise in United States and elsewhere. The tobacco industry also continues to market these products to current cigarette smokers for use in the growing number of "smoke-free environments." Smokeless tobacco products are associated with cancers of the upper aerodigestive tract, particularly the oral cavity, esophagus, and pancreas; cardiovascular diseases; small-for-gestational-age infants; premature births; increased risk of apnea; and stillbirth. There is no convincing evidence regarding the efficacy of smokeless tobacco, including snus, to promote smoking cessation. Rather, studies from Europe and the United States demonstrate that smokeless tobacco use may facilitate regular cigarette smoking by acting as a gateway drug, especially for children. Caution is warranted before proposing smokeless tobacco as a harm-reduction strategy, in part because of the potential for further promoting smokeless tobacco in low- and middle-income countries where use is already widespread. Continued vigilance through comprehensive surveillance is warranted. We strongly recommend the use of graphic warning labels as a "no regrets" strategy for all smokeless tobacco products marketed globally. PMID:26784741

  12. The Case for Requiring Graphic Warning Labels on Smokeless Tobacco Product Packages.

    PubMed

    Pakhale, Smita; Samet, Jonathan; Folan, Patricia; Leone, Frank; White, Alexander

    2016-03-01

    On November 10, 2015, the U.S. Food and Drug Administration approved, for the first time, the sale of smokeless tobacco products authorized under the new premarket tobacco application pathway. This Food and Drug Administration regulatory decision draws attention to the growing worldwide use of smokeless tobacco products in general. Use of these tobacco products is particularly popular in low- and middle-income countries of Asia. Due to aggressive and strategic marketing to children, young adults, and current smokers, rates of smokeless tobacco use in men of all ages are on the rise in United States and elsewhere. The tobacco industry also continues to market these products to current cigarette smokers for use in the growing number of "smoke-free environments." Smokeless tobacco products are associated with cancers of the upper aerodigestive tract, particularly the oral cavity, esophagus, and pancreas; cardiovascular diseases; small-for-gestational-age infants; premature births; increased risk of apnea; and stillbirth. There is no convincing evidence regarding the efficacy of smokeless tobacco, including snus, to promote smoking cessation. Rather, studies from Europe and the United States demonstrate that smokeless tobacco use may facilitate regular cigarette smoking by acting as a gateway drug, especially for children. Caution is warranted before proposing smokeless tobacco as a harm-reduction strategy, in part because of the potential for further promoting smokeless tobacco in low- and middle-income countries where use is already widespread. Continued vigilance through comprehensive surveillance is warranted. We strongly recommend the use of graphic warning labels as a "no regrets" strategy for all smokeless tobacco products marketed globally.

  13. Patterns of combustible tobacco use in U.S. young adults and potential response to graphic cigarette health warning labels.

    PubMed

    Villanti, Andrea C; Pearson, Jennifer L; Cantrell, Jennifer; Vallone, Donna M; Rath, Jessica M

    2015-03-01

    In the evolving landscape of tobacco use, it remains unclear how tobacco control efforts should be designed and promoted for maximum impact. The current study links the identification of latent classes of young adult combustible tobacco users with anticipated responses to graphic health warning labels (HWLs). Data were collected in January 2012 using an online address-based panel as part of the Legacy Young Adult Cohort Study, and analyses were conducted in 2013. Latent class analyses identified five groups of tobacco users in a national sample of 4,236 young adults aged 18-34years: (1) little cigar/cigarillo/bidi (LCC) and hookah users (4%); (2) nonusers, open to smoking (3%); (3) daily smokers who self-identify as "smokers" (11%); (4) nondaily, light smokers who self-identify as "social or occasional smokers" (9%); and (5) nonusers closed to smoking (73%). Of the nonusers closed to smoking, 23% may be better characterized as at risk for tobacco initiation. Results indicate differences in the potential effectiveness of HWLs across classes. Compared to the daily "smokers," LCC and hookah users (RRR=2.35) and nonusers closed to smoking (RRR=2.33) were more than twice as likely to report that new graphic HWLs would make them think about not smoking. This study supports the potential of graphic HWLs to prevent young nonusers from using tobacco products. It suggests that the extension of prominent HWLs to other tobacco products, including LCCs and hookah tobacco, may also serve a prevention function. PMID:25437268

  14. Implementation of graphic health warning labels on tobacco products in India: the interplay between the cigarette and the bidi industries

    PubMed Central

    Sankaran, Sujatha; Hiilamo, Heikki; Glantz, Stanton A

    2014-01-01

    Objectives To understand the competition between and among tobacco companies and health groups that led to graphical health warning labels (GHWL) on all tobacco products in India. Methods Analysis of internal tobacco industry documents in the Legacy Tobacco Document Library, documents obtained through Indias Right to Information ‘ Act, and news reports. Results Implementation of GHWLs in India reflects a complex interplay between the government and the cigarette and bidi industries, who have shared as well as conflicting interests. Joint lobbying by national-level tobacco companies (that are foreign subsidiaries of multinationals) and local producers of other forms of tobacco blocked GHWLs for decades and delayed the implementation of effective GHWLs after they were mandated in 2007. Tobacco control activists used public interest lawsuits and the Right to Information Act to win government implementation of GHWLs on cigarette, bidi and smokeless tobacco packs in May 2009 and rotating GHWLs in December 2011. Conclusions GHWLs in India illustrate how the presence of bidis and cigarettes in the same market creates a complex regulatory environment. The government imposing tobacco control on multinational cigarette companies led to the enforcement of regulation on local forms of tobacco. As other developing countries with high rates of alternate forms of tobacco use establish and enforce GHWL laws, the tobacco control advocacy community can use pressure on the multinational cigarette industry as an indirect tool to force implementation of regulations on other forms of tobacco. PMID:24950697

  15. Paradoxical Effects of Warning in the Production of Children's False Memories

    ERIC Educational Resources Information Center

    Del Prete, Francesco; Mirandola, Chiara; Konishi, Mahiko; Cornoldi, Cesare; Ghetti, Simona

    2014-01-01

    The effects of warning on false recognition and associated subjective experience of false recollection and familiarity were investigated in 7-to 13-year-old children and young adults (N = 259) using the Deese-Roediger-McDermott (DRM) paradigm. Two warning conditions (warning with an example of a critical lure and warning without an example of a…

  16. 21 CFR 101.17 - Food labeling warning, notice, and safe handling statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... children, the elderly, and persons with weakened immune systems. (3) The warning statement required by this...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part...

  17. 21 CFR 101.17 - Food labeling warning, notice, and safe handling statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... children, the elderly, and persons with weakened immune systems. (3) The warning statement required by this...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part...

  18. 21 CFR 101.17 - Food labeling warning, notice, and safe handling statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... children, the elderly, and persons with weakened immune systems. (3) The warning statement required by this...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part...

  19. 21 CFR 101.17 - Food labeling warning, notice, and safe handling statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... children, the elderly, and persons with weakened immune systems. (3) The warning statement required by this...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part...

  20. 21 CFR 101.17 - Food labeling warning, notice, and safe handling statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... children, the elderly, and persons with weakened immune systems. (3) The warning statement required by this...-depleting substance designated by the Environmental Protection Agency (EPA) are set forth in 40 CFR part...

  1. Earthquake Early Warning: User Education and Designing Effective Messages

    NASA Astrophysics Data System (ADS)

    Burkett, E. R.; Sellnow, D. D.; Jones, L.; Sellnow, T. L.

    2014-12-01

    The U.S. Geological Survey (USGS) and partners are transitioning from test-user trials of a demonstration earthquake early warning system (ShakeAlert) to deciding and preparing how to implement the release of earthquake early warning information, alert messages, and products to the public and other stakeholders. An earthquake early warning system uses seismic station networks to rapidly gather information about an occurring earthquake and send notifications to user devices ahead of the arrival of potentially damaging ground shaking at their locations. Earthquake early warning alerts can thereby allow time for actions to protect lives and property before arrival of damaging shaking, if users are properly educated on how to use and react to such notifications. A collaboration team of risk communications researchers and earth scientists is researching the effectiveness of a chosen subset of potential earthquake early warning interface designs and messages, which could be displayed on a device such as a smartphone. Preliminary results indicate, for instance, that users prefer alerts that include 1) a map to relate their location to the earthquake and 2) instructions for what to do in response to the expected level of shaking. A number of important factors must be considered to design a message that will promote appropriate self-protective behavior. While users prefer to see a map, how much information can be processed in limited time? Are graphical representations of wavefronts helpful or confusing? The most important factor to promote a helpful response is the predicted earthquake intensity, or how strong the expected shaking will be at the user's location. Unlike Japanese users of early warning, few Californians are familiar with the earthquake intensity scale, so we are exploring how differentiating instructions between intensity levels (e.g., "Be aware" for lower shaking levels and "Drop, cover, hold on" at high levels) can be paired with self-directed supplemental

  2. Cigarette Graphic Warning Labels and Smoking Prevalence in Canada: A Critical Examination and Reformulation of the FDA Regulatory Impact Analysis

    PubMed Central

    Huang, Jidong; Chaloupka, Frank J.; Fong, Geoffrey T.

    2014-01-01

    Background The estimated effect of cigarette graphic warning labels (GWLs) on smoking rates is a key input to FDA's regulatory impact analysis (RIA), required by law as part of its rulemaking process. However, evidence on the impact of GWLs on smoking prevalence is scarce. Objective The goal of this paper is to critically analyze FDA's approach to estimating the impact of GWLs on smoking rates in its RIA, and to suggest a path forward to estimating the impact of the adoption of GWLs in Canada on Canadian national adult smoking prevalence. Methods A quasi-experimental methodology was employed to examine the impact of adoption of GWLs in Canada in 2000, using the U.S. as a control. Findings We found a statistically significant reduction in smoking rates after the adoption of GWLs in Canada in comparison to the U.S. Our analyses show that implementation of GWLs in Canada reduced smoking rates by 2.87 to 4.68 percentage points, a relative reduction of 12.1 to 19.6% — 33 to 53 times larger than FDA's estimates of a 0.088 percentage point reduction. We also demonstrated that FDA's estimate of the impact was flawed because it is highly sensitive to the changes in variable selection, model specification, and the time period analyzed. Conclusions Adopting GWLs on cigarette packages reduces smoking prevalence. Applying our analysis of the Canadian GWLs, we estimate that if the U.S. had adopted GWLs in 2012, the number of adult smokers in the U.S. would have decreased by 5.3 to 8.6 million in 2013. Our analysis demonstrates that FDA's approach to estimating the impact of GWLs on smoking rates is flawed. Rectifying these problems before this approach becomes the norm is critical for FDA's effective regulation of tobacco products. PMID:24218057

  3. Women’s Perspectives on Smoking and Pregnancy and Graphic Warning Labels

    PubMed Central

    Levis, Denise M.; Stone-Wiggins, Brenda; O’Hegarty, Michelle; Tong, Van T.; Polen, Kara N. D.; Cassell, Cynthia H.; Council, Mary

    2015-01-01

    Objectives To explore women’s knowledge, attitudes, and beliefs about adverse outcomes associated with smoking during pregnancy and which outcomes might motivate cessation; to explore reactions to graphic warnings depicting 2 adverse outcomes. Methods Twelve focus groups were conducted with women of childbearing age who were current smokers. Results Participants had low to moderate awareness of many outcomes and believed it was acceptable to smoke in the first trimester before knowledge of pregnancy. Perceived susceptibility to outcomes was low. Motivators included risk-focused information, especially serious risks to the baby (eg, stillbirth, SIDS). Graphic warnings produced strong reactions, especially the warning with a real photo. Conclusions Despite barriers to reducing rates of smoking during pregnancy, educational information and photos depicting babies’ risks could motivate women to quit. PMID:24933145

  4. Variation in health warning effectiveness on cigarette packs: a need for regulation?

    PubMed Central

    Misak, Monika; Munafò, Marcus R.

    2016-01-01

    The Tobacco Products Directive allows the possibility of strategic placement of health warnings on cigarette packs by manufacturers to reduce overall warning effectiveness. Information regarding health warning effectiveness was assessed in an online survey, and the prevalence of warnings on cigarette packs was assessed in a shop survey. Although we find no evidence of a strong correlation between health warning effectiveness ratings and their frequency on cigarette packs (r = −0.17, P = 0.56), there may be other ways this possibility is exploited. We suggest that this potential loophole is addressed and monitoring of the placement of health warnings on cigarette packs is continued. PMID:27385516

  5. Adolescents' Attention to Traditional and Graphic Tobacco Warning Labels: An Eye-Tracking Approach

    ERIC Educational Resources Information Center

    Peterson, Emily Bylund; Thomsen, Steven; Lindsay, Gordon; John, Kevin

    2010-01-01

    The objective of this study was determine if the inclusion of Canadian-style graphic images would improve the degree to which adolescents attend to, and subsequently are able to recall, novel warning messages in tobacco magazine advertising. Specifically, our goal was to determine if the inclusion of graphic images would 1) increase visual…

  6. Perceptions and Perceived Impact of Graphic Cigarette Health Warning Labels on Smoking Behavior Among U.S. Young Adults

    PubMed Central

    2014-01-01

    Introduction: In 2011, the Food and Drug Administration published a final rule requiring cigarette packages and advertisements to include graphic health warning labels (HWLs) with new warning statements. Implementation of this rule has been stalled by legal challenge. This study assessed correlates of smoking-related intentions related to graphic HWLs among current cigarette smokers and nonsmokers in a national sample of U.S. young adults aged 18–34. Methods: Data were collected from 4,236 participants aged 18–34 using an online panel in January 2012 for the Legacy Young Adult Cohort Study. Analyses were weighted to provide nationally representative estimates. Our main outcome was assessed with a single item: “Do you think that new warning labels with graphic pictures would make you think about not smoking?” Results: Twenty-two percent of the young adults were current cigarette smokers. Fifty-three percent endorsed that new graphic HWLs would make them think about not smoking (40% among current smokers compared with 56% among nonsmokers). Among nonsmokers, those aged 18–24, females, Hispanics, and those who were aware of graphic cigarette HWLs were more likely to report intention to not smoke related to graphic HWLs. Among current smokers, intending to quit within the next 6 months was correlated with intention resulting from graphic HWLs. Hispanic ethnicity and intention to quit within 30 days were strong correlates of intention in light, nondaily, and self-identified social/occasional smokers. Conclusions: This study supports previous findings that graphic HWLs play an important role in preventing smoking, in addition to encouraging cessation in young adults. PMID:24212476

  7. The Use of Vivid Stimuli to Enhance Comprehension of the Content of Product Warning Messages.

    ERIC Educational Resources Information Center

    Kelley, Craig A.; And Others

    1989-01-01

    Two levels of vividness and three levels of motivation were measured in reactions to product label warnings. Vivid product warnings proved to be an effective tool to communicate the hazards associated with product use. (JOW)

  8. When health policy and empirical evidence collide: the case of cigarette package warning labels and economic consumer surplus.

    PubMed

    Song, Anna V; Brown, Paul; Glantz, Stanton A

    2014-02-01

    In its graphic warning label regulations on cigarette packages, the Food and Drug Administration severely discounts the benefits of reduced smoking because of the lost "pleasure" smokers experience when they stop smoking; this is quantified as lost "consumer surplus." Consumer surplus is grounded in rational choice theory. However, empirical evidence from psychological cognitive science and behavioral economics demonstrates that the assumptions of rational choice are inconsistent with complex multidimensional decisions, particularly smoking. Rational choice does not account for the roles of emotions, misperceptions, optimistic bias, regret, and cognitive inefficiency that are germane to smoking, particularly because most smokers begin smoking in their youth. Continued application of a consumer surplus discount will undermine sensible policies to reduce tobacco use and other policies to promote public health. PMID:24328661

  9. When Health Policy and Empirical Evidence Collide: The Case of Cigarette Package Warning Labels and Economic Consumer Surplus

    PubMed Central

    Song, Anna V.; Brown, Paul

    2014-01-01

    In its graphic warning label regulations on cigarette packages, the Food and Drug Administration severely discounts the benefits of reduced smoking because of the lost “pleasure” smokers experience when they stop smoking; this is quantified as lost “consumer surplus.” Consumer surplus is grounded in rational choice theory. However, empirical evidence from psychological cognitive science and behavioral economics demonstrates that the assumptions of rational choice are inconsistent with complex multidimensional decisions, particularly smoking. Rational choice does not account for the roles of emotions, misperceptions, optimistic bias, regret, and cognitive inefficiency that are germane to smoking, particularly because most smokers begin smoking in their youth. Continued application of a consumer surplus discount will undermine sensible policies to reduce tobacco use and other policies to promote public health. PMID:24328661

  10. The Impact of Graphic Cigarette Warning Labels and Smoke-Free Law on Health Awareness and Thoughts of Quitting in Taiwan

    ERIC Educational Resources Information Center

    Chang, Fong-Ching; Chung, Chi-Hui; Yu, Po-Tswen; Chao, Kun-yu

    2011-01-01

    The present study evaluated the impact of Taiwan's graphic cigarette warning labels and smoke-free law on awareness of the health hazards of smoking and thoughts of quitting smoking. National representative samples of 1074 and 1094 people, respectively, were conducted successfully by telephone in July 2008 (pre-law) and March 2009 (post-law).…

  11. The Effect of Sonic Booms on Earthquake Warning Systems

    NASA Technical Reports Server (NTRS)

    Wurman, Gilead; Haering, Edward A, Jr.; Price, Michael J.

    2011-01-01

    Several aerospace companies are designing quiet supersonic business jets for service over the United States. These aircraft have the potential to increase the occurrence of mild sonic booms across the country. This leads to interest among earthquake warning (EQW) developers and the general seismological community in characterizing the effect of sonic booms on seismic sensors in the field, their potential impact on EQW systems, and means of discriminating their signatures from those of earthquakes. The SonicBREWS project (Sonic Boom Resistant Earthquake Warning Systems) is a collaborative effort between Seismic Warning Systems, Inc. (SWS) and NASA Dryden Flight Research Center. This project aims to evaluate the effects of sonic booms on EQW sensors. The study consists of exposing high-sample-rate (1000 sps) triaxial accelerometers to sonic booms with overpressures ranging from 10 to 600 Pa in the free field and the built environment. The accelerometers record the coupling of the sonic boom to the ground and surrounding structures, while microphones record the acoustic wave above ground near the sensor. Sonic booms are broadband signals with more high-frequency content than earthquakes. Even a 1000 sps accelerometer will produce a significantly aliased record. Thus the observed peak ground velocity is strongly dependent on the sampling rate, and increases as the sampling rate is reduced. At 1000 sps we observe ground velocities that exceed those of P-waves from ML 3 earthquakes at local distances, suggesting that sonic booms are not negligible for EQW applications. We present the results of several experiments conducted under SonicBREWS showing the effects of typical-case low amplitude sonic booms and worst-case high amplitude booms. We show the effects of various sensor placements and sensor array geometries. Finally, we suggest possible avenues for discriminating sonic booms from earthquakes for the purposes of EQW.

  12. Off-Label Prescribing, Polypharmacy, and Black-Box Warnings: A Primer for School Psychologists

    ERIC Educational Resources Information Center

    Shahidullah, Jeffrey D.

    2012-01-01

    Psychotropic medications are increasingly used to treat children and adolescents with mental health conditions. Between the years 1994 and 2001, there was a 191.7% increase in number of office visits resulting in a psychotropic medication prescription among children and adolescents. Many drugs are prescribed to children "off-label", whereby they…

  13. Art and the Craft of Avoidance: Toxic Art Supplies Lack Warnings Despite Federal Labeling Law.

    ERIC Educational Resources Information Center

    Sikes, Lucinda

    Despite federal law requiring that art and craft materials be labeled, many products continue to be sold without adequate identification of their contents. This report summarizes the findings of the U.S. Public Interest Research Group (PIRG) which conducted an investigation in June and July 1991 to determine how art and craft manufacturers comply…

  14. Effect of Graphic Cigarette Warnings on Smoking Intentions in Young Adults

    PubMed Central

    Blanton, Hart; Snyder, Leslie B.; Strauts, Erin; Larson, Joy G.

    2014-01-01

    Introduction Graphic warnings (GWs) on cigarette packs are widely used internationally and perhaps will be in the US but their impact is not well understood. This study tested support for competing hypotheses in different subgroups of young adults defined by their history of cigarette smoking and individual difference variables (e.g., psychological reactance). One hypothesis predicted adaptive responding (GWs would lower smoking-related intentions) and another predicted defensive responding (GWs would raise smoking-related intentions). Methods Participants were an online sample of 1,169 Americans ages 18–24, who were randomly assigned either to view nine GWs designed by the FDA or to a no-label control. Both the intention to smoke in the future and the intention to quit smoking (among smokers) were assessed before and after message exposure. Results GWs lowered intention to smoke in the future among those with a moderate lifetime smoking history (between 1 and 100 cigarettes), and they increased intention to quit smoking among those with a heavy lifetime smoking history (more than 100 cigarettes). Both effects were limited to individuals who had smoked in some but not all of the prior 30 days (i.e., occasional smokers). No evidence of defensive “boomerang effects” on intention was observed in any subgroup. Conclusion Graphic warnings can reduce interest in smoking among occasional smokers, a finding that supports the adaptive-change hypothesis. GWs that target occasional smokers might be more effective at reducing cigarette smoking in young adults. PMID:24806481

  15. Pictorial health warning label content and smokers’ understanding of smoking-related risks—a cross-country comparison

    PubMed Central

    Swayampakala, Kamala; Thrasher, James F.; Hammond, David; Yong, Hua-Hie; Bansal-Travers, Maansi; Krugman, Dean; Brown, Abraham; Borland, Ron; Hardin, James

    2015-01-01

    The aim of the present study was to assess smokers’ level of agreement with smoking-related risks and toxic tobacco constituents relative to inclusion of these topics on health warning labels (HWLs). 1000 adult smokers were interviewed between 2012 and 2013 from online consumer panels of adult smokers from each of the three countries: Australia (AU), Canada (CA) and Mexico (MX). Generalized estimating equation models were estimated to compare agreement with smoking-related risks and toxic tobacco constituents. For disease outcomes described on HWLs across all three countries, there were few statistical differences in agreement with health outcomes (e.g. emphysema and heart attack). By contrast, increases in agreement where the HWLs were revised or introduced on HWLs for the first time (e.g. blindness in AU and CA, bladder cancer in CA). Similarly, samples from countries that have specific health content or toxic constituents on HWLs showed higher agreement for that particular disease or toxin than countries without (e.g. higher agreement for gangrene and blindness in AU, higher agreement for bladder cancer and all toxic constituents except nitrosamines and radioactive polonium in CA). Pictorial HWL content is associated with greater awareness of smoking-related risks and toxic tobacco constituents. PMID:24848554

  16. Pictorial health warning label content and smokers' understanding of smoking-related risks-a cross-country comparison.

    PubMed

    Swayampakala, Kamala; Thrasher, James F; Hammond, David; Yong, Hua-Hie; Bansal-Travers, Maansi; Krugman, Dean; Brown, Abraham; Borland, Ron; Hardin, James

    2015-02-01

    The aim of the present study was to assess smokers' level of agreement with smoking-related risks and toxic tobacco constituents relative to inclusion of these topics on health warning labels (HWLs). 1000 adult smokers were interviewed between 2012 and 2013 from online consumer panels of adult smokers from each of the three countries: Australia (AU), Canada (CA) and Mexico (MX). Generalized estimating equation models were estimated to compare agreement with smoking-related risks and toxic tobacco constituents. For disease outcomes described on HWLs across all three countries, there were few statistical differences in agreement with health outcomes (e.g. emphysema and heart attack). By contrast, increases in agreement where the HWLs were revised or introduced on HWLs for the first time (e.g. blindness in AU and CA, bladder cancer in CA). Similarly, samples from countries that have specific health content or toxic constituents on HWLs showed higher agreement for that particular disease or toxin than countries without (e.g. higher agreement for gangrene and blindness in AU, higher agreement for bladder cancer and all toxic constituents except nitrosamines and radioactive polonium in CA). Pictorial HWL content is associated with greater awareness of smoking-related risks and toxic tobacco constituents. PMID:24848554

  17. Promoting cessation resources through cigarette package warning labels: a longitudinal survey with adult smokers in Canada, Australia and Mexico

    PubMed Central

    Thrasher, James F; Osman, Amira; Moodie, Crawford; Hammond, David; Bansal-Travers, Maansi; Cummings, K Michael; Borland, Ron; Yong, Hua-Hie; Hardin, James

    2015-01-01

    Introduction Health warning labels (HWLs) on tobacco packaging can be used to provide smoking cessation information, but the impact of this information is not well understood. Methods Online consumer panels of adult smokers from Canada, Australia and Mexico were surveyed in September 2012, January 2013 and May 2013; replenishment was used to maintain sample sizes of 1000 participants in each country at each wave. Country-stratified logistic Generalised Estimating Equation (GEE) models were estimated to assess correlates of citing HWLs as a source of information on quitlines and cessation websites. GEE models also regressed having called the quitline, and having visited a cessation website, on awareness of these resources because of HWLs. Results At baseline, citing HWLs as a source of information about quitlines was highest in Canada, followed by Australia and Mexico (33%, 19% and 16%, respectively). Significant increases over time were only evident in Australia and Mexico. In all countries, citing HWLs as a source of quitline information was significantly associated with self-report of having called a quitline. At baseline, citing HWLs as a source of information about cessation websites was higher in Canada than in Australia (14% and 6%, respectively; Mexico was excluded because HWLs do not include website information), but no significant changes over time were found for either country. Citing HWLs as a source of information about cessation websites was significantly associated with having visited a website in both Canada and Australia. Conclusions HWLs are an important source of cessation information. PMID:25052860

  18. An evaluation of the FDA's analysis of the costs and benefits of the graphic warning label regulation.

    PubMed

    Chaloupka, Frank J; Warner, Kenneth E; Acemoğlu, Daron; Gruber, Jonathan; Laux, Fritz; Max, Wendy; Newhouse, Joseph; Schelling, Thomas; Sindelar, Jody

    2015-03-01

    The Family Smoking Prevention and Tobacco Control Act of 2009 gave the Food and Drug Administration (FDA) regulatory authority over cigarettes and smokeless tobacco products and authorised it to assert jurisdiction over other tobacco products. As with other Federal agencies, FDA is required to assess the costs and benefits of its significant regulatory actions. To date, FDA has issued economic impact analyses of one proposed and one final rule requiring graphic warning labels (GWLs) on cigarette packaging and, most recently, of a proposed rule that would assert FDA's authority over tobacco products other than cigarettes and smokeless tobacco. Given the controversy over the FDA's approach to assessing net economic benefits in its proposed and final rules on GWLs and the importance of having economic impact analyses prepared in accordance with sound economic analysis, a group of prominent economists met in early 2014 to review that approach and, where indicated, to offer suggestions for an improved analysis. We concluded that the analysis of the impact of GWLs on smoking substantially underestimated the benefits and overestimated the costs, leading the FDA to substantially underestimate the net benefits of the GWLs. We hope that the FDA will find our evaluation useful in subsequent analyses, not only of GWLs but also of other regulations regarding tobacco products. Most of what we discuss applies to all instances of evaluating the costs and benefits of tobacco product regulation and, we believe, should be considered in FDA's future analyses of proposed rules. PMID:25550419

  19. An evaluation of the FDA's analysis of the costs and benefits of the graphic warning label regulation

    PubMed Central

    Chaloupka, Frank J; Warner, Kenneth E; Acemoğlu, Daron; Gruber, Jonathan; Laux, Fritz; Max, Wendy; Newhouse, Joseph; Schelling, Thomas; Sindelar, Jody

    2015-01-01

    The Family Smoking Prevention and Tobacco Control Act of 2009 gave the Food and Drug Administration (FDA) regulatory authority over cigarettes and smokeless tobacco products and authorised it to assert jurisdiction over other tobacco products. As with other Federal agencies, FDA is required to assess the costs and benefits of its significant regulatory actions. To date, FDA has issued economic impact analyses of one proposed and one final rule requiring graphic warning labels (GWLs) on cigarette packaging and, most recently, of a proposed rule that would assert FDA’s authority over tobacco products other than cigarettes and smokeless tobacco. Given the controversy over the FDA's approach to assessing net economic benefits in its proposed and final rules on GWLs and the importance of having economic impact analyses prepared in accordance with sound economic analysis, a group of prominent economists met in early 2014 to review that approach and, where indicated, to offer suggestions for an improved analysis. We concluded that the analysis of the impact of GWLs on smoking substantially underestimated the benefits and overestimated the costs, leading the FDA to substantially underestimate the net benefits of the GWLs. We hope that the FDA will find our evaluation useful in subsequent analyses, not only of GWLs but also of other regulations regarding tobacco products. Most of what we discuss applies to all instances of evaluating the costs and benefits of tobacco product regulation and, we believe, should be considered in FDA's future analyses of proposed rules. PMID:25550419

  20. Assessing the impact of cigarette package health warning labels: a cross-country comparison in Brazil, Uruguay, and Mexico

    PubMed Central

    Thrasher, James F; Villalobos, Victor; Szklo, André; Fong, Geoffrey T; Pérez, Cristina; Sebrié, Ernesto; Sansone, Natalie; Figueiredo, Valeska; Boado, Marcelo; Arillo-Santillán, Edna; Bianco, Eduardo

    2015-01-01

    Objective To assess the impact of different health warning labels (HWL). Material and Methods Data from the International Tobacco Control Survey (ITC Survey) were analyzed from adult smokers in Brazil, Uruguay and Mexico, each of which used a different HWL strategy (pictures of human suffering and diseased organs; abstract pictorial representations of risk; and text-only messages, respectively). Main outcomes were HWL salience and cognitive impact. Results HWLs in Uruguay (which was the only country with a HWL on the front of the package) had higher salience than either Brazilian or Mexican packs. People at higher levels of educational attainment in Mexico were more likely to read the text-only HWLs whereas education was unassociated with salience in Brazil or Uruguay. Brazilian HWLs had greater cognitive impacts than HWLs in either Uruguay or Mexico. HWLs in Uruguay generated lower cognitive impacts than the text-only HWLs in Mexico. In Brazil, cognitive impacts were strongest among smokers with low educational attainment. Conclusions This study suggests that HWLs have the most impact when they are prominent (i.e., front and back of the package) and include emotionally engaging imagery that illustrates negative bodily impacts or human suffering due to smoking. PMID:21243191

  1. A word of warning: Instructions and feedback cannot prevent the revelation effect.

    PubMed

    Aßfalg, André; Nadarevic, Lena

    2015-07-01

    In recognition tests, participants claim that stimuli appear more familiar after an intervening task (e.g., solving an anagram) than without an intervening task-the revelation effect. In Experiment 1, we warned half of the participants about the revelation effect and asked them to prevent any judgment bias. However, compared to a control group without warning instructions, the revelation effect remained unaltered. In Experiment 2, participants who received warning instructions additionally received accuracy feedback for their recognition judgments. We assumed that feedback would aid participants in detecting any judgment bias. Again, warning instructions and feedback failed to reduce the revelation effect. In Experiment 3, participants demonstrated that they understood the warning instructions and generally believed that they were successful in suppressing the revelation effect. Yet, again, a revelation effect occurred. The experiments suggest that the revelation effect is a robust judgment bias that lies outside of the participants' control.

  2. A word of warning: Instructions and feedback cannot prevent the revelation effect.

    PubMed

    Aßfalg, André; Nadarevic, Lena

    2015-07-01

    In recognition tests, participants claim that stimuli appear more familiar after an intervening task (e.g., solving an anagram) than without an intervening task-the revelation effect. In Experiment 1, we warned half of the participants about the revelation effect and asked them to prevent any judgment bias. However, compared to a control group without warning instructions, the revelation effect remained unaltered. In Experiment 2, participants who received warning instructions additionally received accuracy feedback for their recognition judgments. We assumed that feedback would aid participants in detecting any judgment bias. Again, warning instructions and feedback failed to reduce the revelation effect. In Experiment 3, participants demonstrated that they understood the warning instructions and generally believed that they were successful in suppressing the revelation effect. Yet, again, a revelation effect occurred. The experiments suggest that the revelation effect is a robust judgment bias that lies outside of the participants' control. PMID:25881234

  3. Appliance energy labeling takes effect

    SciTech Connect

    Not Available

    1980-06-01

    Consumers buying household appliances will be helped by energy-efficiency labels and minimum efficiency standards required for refrigerators and refrigerator/freezers, freezers, dishwashers, water heaters, clothes washers, room air conditioners, and furnaces. The ENERGYGUIDE labels must be displayed in the store and in catalogs. Two voluntary efficiency programs were combined in the Energy Policy and Conservation Act (EPCA) requiring labels by 1980. Shoppers may compare the efficiencies of appliances and compute the actual cost differential over the lifetime of the equipment. Manufacturers have responded with more-efficient models, but the impact of efficient appliances on energy consumption will be small. A sample label with the required information is illustrated. (DCK)

  4. Examining the conspicuousness and prominence of two required warnings on OTC pain relievers

    PubMed Central

    Bix, Laura; Bello, Nora M.; Auras, Rafael; Ranger, Jon; Lapinski, Maria K.

    2009-01-01

    The labeling of over-the-counter (OTC) drugs is critical to their safe and effective use, and certain warnings are meant to be read at the point of purchase (POP). Examples include (i) warnings that alert consumers to the fact that the package is not child-resistant and (ii) warnings that alert consumers to potential product tampering. U.S. law mandates these warnings be “conspicuous” and “prominent” so that it is likely that consumers will read them before leaving the store. Our objective was to quantify the relative prominence and conspicuousness of these warnings. Sixty-one participants reviewed the packages of 5 commercially available analgesics to evaluate the prominence and conspicuousness of these warnings. Evaluated data included (i) the time spent examining the warnings compared with other areas of the label (using a bright pupil eye tracker), (ii) the ability to recall information from the OTCs viewed, and (iii) the legibility of the warnings relative to other elements of the labels (as measured by ASTM D7298-06). Eye-tracking data indicated that warnings were viewed by fewer participants and for less time than other elements of the packages. Recall and legibility data also indicated that the warning statements compared unfavorably with other elements of the labels tested. Evidence presented in this study suggests that 2 required warnings on 5 different OTCs are not prominent or conspicuous when compared with other elements of tested labels. PMID:19332798

  5. Examining the conspicuousness and prominence of two required warnings on OTC pain relievers.

    PubMed

    Bix, Laura; Bello, Nora M; Auras, Rafael; Ranger, Jon; Lapinski, Maria K

    2009-04-21

    The labeling of over-the-counter (OTC) drugs is critical to their safe and effective use, and certain warnings are meant to be read at the point of purchase (POP). Examples include (i) warnings that alert consumers to the fact that the package is not child-resistant and (ii) warnings that alert consumers to potential product tampering. U.S. law mandates these warnings be "conspicuous" and "prominent" so that it is likely that consumers will read them before leaving the store. Our objective was to quantify the relative prominence and conspicuousness of these warnings. Sixty-one participants reviewed the packages of 5 commercially available analgesics to evaluate the prominence and conspicuousness of these warnings. Evaluated data included (i) the time spent examining the warnings compared with other areas of the label (using a bright pupil eye tracker), (ii) the ability to recall information from the OTCs viewed, and (iii) the legibility of the warnings relative to other elements of the labels (as measured by ASTM D7298-06). Eye-tracking data indicated that warnings were viewed by fewer participants and for less time than other elements of the packages. Recall and legibility data also indicated that the warning statements compared unfavorably with other elements of the labels tested. Evidence presented in this study suggests that 2 required warnings on 5 different OTCs are not prominent or conspicuous when compared with other elements of tested labels.

  6. Response time effects of alerting tone and semantic context for synthesized voice cockpit warnings

    NASA Technical Reports Server (NTRS)

    Simpson, C. A.; Williams, D. H.

    1980-01-01

    Some handbooks and human factors design guides have recommended that a voice warning should be preceded by a tone to attract attention to the warning. As far as can be determined from a search of the literature, no experimental evidence supporting this exists. A fixed-base simulator flown by airline pilots was used to test the hypothesis that the total 'system-time' to respond to a synthesized voice cockpit warning would be longer when the message was preceded by a tone because the voice itself was expected to perform both the alerting and the information transfer functions. The simulation included realistic ATC radio voice communications, synthesized engine noise, cockpit conversation, and realistic flight routes. The effect of a tone before a voice warning was to lengthen response time; that is, responses were slower with an alerting tone. Lengthening the voice warning with another work, however, did not increase response time.

  7. The effect of warnings on false memories in young and older adults.

    PubMed

    McCabe, David P; Smith, Anderson D

    2002-10-01

    In the present experiments, we examined adult age differences in the ability to suppress false memories, using the Deese-Roediger-McDermott (DRM) paradigm (Deese, 1959; Roediger & McDermott, 1995). Participants studied lists of words (e.g., bed, rest, awake, etc.), each related to a nonpresented critical lure word (e.g., sleep). Typically, recognition tests reveal false alarms to critical lures at rates comparable to those for hits for studied words. In two experiments, separate groups of young and older adults were unwarned about the false memory effect, warned before studying the lists, or warned after study and before test. Lists were presented at either a slow rate (4 sec/word) or a faster rate (2 sec/word). Young adults were better able to discriminate between studied words and critical lures when warned about the DRM effect either before study or after study but before retrieval, and their performance improved with a slower presentation rate. Older adults were able to discriminate between studied words and critical lures when given warnings before study, but not when given warnings after study but before retrieval. Performance on a working memory capacity measure predicted false recognition following study and retrieval warnings. The results suggest that effective use of warnings to reduce false memories is contingent on the quality and type of encoded information, as well as on whether that information is accessed at retrieval. Furthermore, discriminating between similar sources of activation is dependent on working memory capacity, which declines with advancing age. PMID:12507371

  8. Psychological effectiveness of carbon labelling

    NASA Astrophysics Data System (ADS)

    Beattie, Geoffrey

    2012-04-01

    Despite the decision by supermarket-giant Tesco to delay its plan to add carbon-footprint information onto all of its 70,000 products, carbon labelling, if carefully designed, could yet change consumer behaviour. However, it requires a new type of thinking about consumers and much additional work.

  9. Exposure to Prescription Drugs Labeled for Risk of Adverse Effects of Suicidal Behavior or Ideation among 100 Air Force Personnel Who Died by Suicide, 2006-2009

    ERIC Educational Resources Information Center

    Lavigne, Jill E.; McCarthy, Michael; Chapman, Richard; Petrilla, Allison; Knox, Kerry L.

    2012-01-01

    Prescription drugs for many indications are labeled with warnings for potential risk of suicidal ideation or behavior. Exposures to prescription drugs labeled for adverse effects of suicidal behavior or ideation among 100 Air Force personnel who died by suicide between 2006 and 2009 are described. Air Force registry data were linked to…

  10. Quantifying the effect of early warning systems for mitigating risks from alpine hazards

    NASA Astrophysics Data System (ADS)

    Straub, Daniel; Sättele, Martina; Bründl, Michael

    2016-04-01

    Early warning systems (EWS) are increasingly applied as flexible and non-intrusive measures for mitigating risks from alpine hazards. They are typically planed and installed in an ad-hoc manner and their effectiveness is not quantified, which is in contrast to structural risk mitigation measures. The effect of an EWS on the risk depends on human decision makers: experts interpret the signals from EWS, authorities decide on intervention measures and the public responds to the warnings. This interaction of the EWS with humans makes the quantification of their effectiveness challenging. Nevertheless, such a quantification is an important step in understanding, improving and justifying the use of EWS. We systematically discuss and demonstrate the factors that influence EWS effectiveness for alpine hazards, and present approaches and tools for analysing them. These include Bayesian network models, which are a powerful tool for an integral probabilistic assessment. The theory is illustrated through applications of warning systems for debris flow and rockfall hazards. References: Sättele M., Bründl M., Straub D. (in print). Quantifying the effectiveness of early warning systems for natural hazards. Natural Hazards and Earth System Sciences. Sättele M., Bründl M., Straub D. (2015). Reliability and Effectiveness of Warning Systems for Natural Hazards: Concepts and Application to Debris Flow Warning. Reliability Engineering & System Safety, 142: 192-202

  11. The effectiveness and limitations of regulatory warnings for the safe prescribing of citalopram

    PubMed Central

    Friesen, Kevin J; Bugden, Shawn C

    2015-01-01

    Background Citalopram is the most commonly prescribed antidepressant in Canada. Concerns have been raised about its cardiac safety, and a dose-dependent prolongation of the QT interval has been documented. Drug interactions involving concomitant use of other medications that prolong the QT interval or increase citalopram levels by interfering with its metabolism increase the cardiac risk. Regulatory bodies (Health Canada and the US Food and Drug Administration) issued warnings and required labeling changes in 2011/2012, suggesting maximum citalopram doses (<40 mg for those <65 years; <20 mg for those ≥65 years) and avoiding drug interactions that increase cardiac risk. The purpose of this study is to assess the impact of these warnings on citalopram prescribing practices. Methods A quasi-experimental interrupted time series analysis was conducted using all citalopram prescribing data from the population of Manitoba, Canada from 1999 to 2014. This allowed for the examination of high-dose prescribing (above regulatory warning levels) and the number of interacting medications per citalopram prescription. Results There was a dramatic decline in the prescribing of high doses in both age groups, with a 64.8% decline in those <65 years and 33.6% in those ≥65 years. Segmented regression models indicated significant breakpoints in the third quarter of 2011 for both age groups (P<0.0001), corresponding to the time the regulatory warnings were issued. There appeared to be no impact of the warnings on the prescribing of interacting medications. The number of interacting medications actually increased in the postwarning period (<65, 0.78–0.81 interactions per citalopram prescription; ≥65, 0.93–0.94, P<0.001). Conclusion Regulatory changes appear to have produced an important reduction in the high-dose prescribing of citalopram. In contrast to this relatively simple dosage change, there was no indication that the more complex issue of resolving drug–drug interactions

  12. Implicit Motivational Impact of Pictorial Health Warning on Cigarette Packs

    PubMed Central

    Volchan, Eliane; David, Isabel A.; Tavares, Gisella; Nascimento, Billy M.; Oliveira, Jose M.; Gleiser, Sonia; Szklo, Andre; Perez, Cristina; Cavalcante, Tania; Pereira, Mirtes G.; Oliveira, Leticia

    2013-01-01

    Objective The use of pictorial warning labels on cigarette packages is one of the provisions included in the first ever global health treaty by the World Health Organization against the tobacco epidemic. There is substantial evidence demonstrating the effectiveness of graphic health warning labels on intention to quit, thoughts about health risks and engaging in cessation behaviors. However, studies that address the implicit emotional drives evoked by such warnings are still underexplored. Here, we provide experimental data for the use of pictorial health warnings as a reliable strategy for tobacco control. Methods Experiment 1 pre-tested nineteen prototypes of pictorial warnings to screen for their emotional impact. Participants (n = 338) were young adults balanced in gender, smoking status and education. Experiment 2 (n = 63) tested pictorial warnings (ten) that were stamped on packs. We employed an innovative set-up to investigate the impact of the warnings on the ordinary attitude of packs’ manipulation, and quantified judgments of warnings’ emotional strength and efficacy against smoking. Findings Experiment 1 revealed that women judged the warning prototypes as more aversive than men, and smokers judged them more aversive than non-smokers. Participants with lower education judged the prototypes more aversive than participants with higher education. Experiment 2 showed that stamped warnings antagonized the appeal of the brands by imposing a cost to manipulate the cigarette packs, especially for smokers. Additionally, participants’ judgments revealed that the more aversive a warning, the more it is perceived as effective against smoking. Conclusions Health warning labels are one of the key components of the integrated approach to control the global tobacco epidemic. The evidence presented in this study adds to the understanding of how implicit responses to pictorial warnings may contribute to behavioral change. PMID:23977223

  13. Abandoning a label doesn’t make it disappear: The perseverance of labeling effects

    PubMed Central

    Foroni, Francesco; Rothbart, Myron

    2012-01-01

    Labels exert strong influence on perception and judgment. The present experiment examines the possibility that such effects may persist even when labels are abandoned. Participants judged the similarity of pairs of silhouette drawings of female body types, ordered on a continuum from very thin to very heavy, under conditions where category labels were, and were not, superimposed on the ordered stimuli. Consistent with earlier research, labels had strong effects on perceived similarity, with silhouettes sharing the same label judged as more similar than those having different labels. Moreover, when the labels were removed and no longer present, the effect of the labels, although diminished, persisted. It did not make any difference whether the labels were simply abandoned or, in addition, had their validity challenged. The results are important for our understanding of categorization and labeling processes. The potential theoretical and practical implications of these results for social processes are discussed. PMID:23105148

  14. Effects of Shared Electronic Health Record Systems on Drug-Drug Interaction and Duplication Warning Detection

    PubMed Central

    Rinner, Christoph; Grossmann, Wilfried; Sauter, Simone Katja; Wolzt, Michael; Gall, Walter

    2015-01-01

    Shared electronic health records (EHRs) systems can offer a complete medication overview of the prescriptions of different health care providers. We use health claims data of more than 1 million Austrians in 2006 and 2007 with 27 million prescriptions to estimate the effect of shared EHR systems on drug-drug interaction (DDI) and duplication warnings detection and prevention. The Austria Codex and the ATC/DDD information were used as a knowledge base to detect possible DDIs. DDIs are categorized as severe, moderate, and minor interactions. In comparison to the current situation where only DDIs between drugs issued by a single health care provider can be checked, the number of warnings increases significantly if all drugs of a patient are checked: severe DDI warnings would be detected for 20% more persons, and the number of severe DDI warnings and duplication warnings would increase by 17%. We show that not only do shared EHR systems help to detect more patients with warnings but DDIs are also detected more frequently. Patient safety can be increased using shared EHR systems. PMID:26682218

  15. Effects of publicity and a warning letter on illegal cigarette sales to minors.

    PubMed

    Chapman, S; King, M; Andrews, B; McKay, E; Markham, P; Woodward, S

    1994-03-01

    The study aimed to assess rates of illegal cigarette sales to children and the impact on these rates of publicity and a warning letter threatening prosecution. Children aged 12 and 13 made two repeat purchasing attempts, three months apart, at 255 randomly selected tobacco retail outlets in Sydney. A randomly selected 50 per cent of retail outlets which sold cigarettes illegally at the first attempt were sent warning letters threatening prosecution. Publicity about the undercover buying operation was organised between the attempts. At the first attempts, 39 per cent of shops sold cigarettes to the children and 32 per cent sold them at the second attempt. Shops which sold on the first occasion and received warning letters reduced selling by 69 per cent compared to the 40 per cent reduction in shops which sold cigarettes on the first attempt and were not sent warning letters, a net reduction of 29 per cent seemingly attributable to the warning letters (95 per cent confidence interval 8 per cent to 50 per cent). It is extremely easy for children as young as 12 to buy cigarettes. The combined effects of publicity about undercover buying operations and warning letters threatening prosecution seem capable of reducing selling by about 29 per cent. Because of inconsistencies in selling or refusals, future attempts to measure selling rates to children should use repeat purchasing attempts and classify outlets as 'selling', 'not selling' or 'sometimes selling'. PMID:8068791

  16. Developing effective warning systems: Ongoing research at Ruapehu volcano, New Zealand

    NASA Astrophysics Data System (ADS)

    Leonard, Graham S.; Johnston, David M.; Paton, Douglas; Christianson, Amy; Becker, Julia; Keys, Harry

    2008-05-01

    PurposeThis paper examines the unique challenges to volcanic risk management associated with having a ski area on an active volcano. Using a series of simulated eruption/lahar events at Ruapehu volcano, New Zealand, as a context, a model of risk management that integrates warning system design and technology, risk perceptions and the human response is explored. Principal resultsDespite increases in the observed audibility and comprehension of the warning message, recall of public education content, and people's awareness of volcanic risk, a persistent minority of the public continued to demonstrate only moderate awareness of the correct actions to take during a warning and failed to respond effectively. A relationship between level of staff competence and correct public response allowed the level of public response to be used to identify residual risk and additional staff training needs. The quality of staff awareness, action and decision-making has emerged as a critical factor, from detailed staff and public interviews and from exercise observations. Staff actions are especially important for mobilising correct public response at Ruapehu ski areas due to the transient nature of the visitor population. Introduction of education material and staff training strategies that included the development of emergency decision-making competencies improved knowledge of correct actions, and increased the proportion of people moving out of harm's way during blind tests. Major conclusionsWarning effectiveness is a function of more than good hazard knowledge and the generation and notification of an early warning message. For warning systems to be effective, these factors must be complemented by accurate knowledge of risk and risk management actions. By combining the Ruapehu findings with those of other warning system studies in New Zealand, and internationally, a practical five-step model for effective early warning systems is discussed. These steps must be based upon sound and

  17. Synthesized speech rate and pitch effects on intelligibility of warning messages for pilots

    NASA Technical Reports Server (NTRS)

    Simpson, C. A.; Marchionda-Frost, K.

    1984-01-01

    In civilian and military operations, a future threat-warning system with a voice display could warn pilots of other traffic, obstacles in the flight path, and/or terrain during low-altitude helicopter flights. The present study was conducted to learn whether speech rate and voice pitch of phoneme-synthesized speech affects pilot accuracy and response time to typical threat-warning messages. Helicopter pilots engaged in an attention-demanding flying task and listened for voice threat warnings presented in a background of simulated helicopter cockpit noise. Performance was measured by flying-task performance, threat-warning intelligibility, and response time. Pilot ratings were elicited for the different voice pitches and speech rates. Significant effects were obtained only for response time and for pilot ratings, both as a function of speech rate. For the few cases when pilots forgot to respond to a voice message, they remembered 90 percent of the messages accurately when queried for their response 8 to 10 sec later.

  18. Assessing effectiveness of various auditory warning signals in maintaining drivers' attention in virtual reality-based driving environments.

    PubMed

    Lin, Chin-Teng; Chiu, Tien-Ting; Huang, Teng-Yi; Chao, Chih-Feng; Liang, Wen-Chieh; Hsu, Shang-Hwa; Ko, Li-Wei

    2009-06-01

    Drivers' fatigue contributes to traffic accidents, so drivers must maintain adequate alertness. The effectiveness of audio alarms in maintaining driving performance and characteristics of alarms was studied in a virtural reality-based driving environment. Response time to the car's drifting was measured under seven conditions: with no warnings and with continuous warning tones (500 Hz, 1750 Hz, and 3000 Hz), and with tone bursts at 500 Hz, 1750 Hz, and 3000 Hz. Analyses showed the audio warning signals significantly improved driving. Further, the tones' spectral characteristics significantly influenced the effectiveness of the warning.

  19. Immediate skin responses to laser and light treatments: Warning endpoints: How to avoid side effects.

    PubMed

    Wanner, Molly; Sakamoto, Fernanda H; Avram, Mathew M; Anderson, R Rox

    2016-05-01

    Lasers are versatile, commonly used treatment tools in dermatology. While it is tempting to follow manufacturer's guidelines or other "recipes" for laser treatment, this approach alone can be a recipe for disaster. Specific and immediate skin responses or endpoints exist and are clinically useful because they correlate with underlying mechanisms that are either desirable (ie, therapeutic), undesirable (ie, warning signs of injury or side effects), or incidental. The observation of clinical endpoints is a safe and reliable guide for appropriate treatment. This article presents the warning endpoints during specific dermatologic laser treatments, and the accompanying article presents the therapeutic endpoints, their underlying mechanisms, and the utility of these endpoints. PMID:27085227

  20. FDA Bolsters Warnings about Class of Antibiotics

    MedlinePlus

    ... 160078.html FDA Bolsters Warnings About Class of Antibiotics Fluoroquinolones such as Cipro, Levaquin should be reserved ... it's strengthening label warnings on a class of antibiotics called fluoroquinolones because the drugs can lead to ...

  1. Effects of culture (China vs. US) and task on perceived hazard: Evidence from product ratings, label ratings, and product to label matching.

    PubMed

    Lesch, Mary F; Rau, Pei-Luen Patrick; Choi, YoonSun

    2016-01-01

    In the current study, 44 Chinese and 40 US college students rated their perceived hazard in response to warning labels and products and attempted to match products with warning labels communicating the same level of hazard. Chinese participants tended to provide lower ratings of hazard in response to labels, but hazard perceived in response to products did not significantly differ as a function of culture. When asked to match a product with a warning label, Chinese participants' hazard perceptions appeared to be better calibrated, than did US participants', across products and labels. The results are interpreted in terms of constructivist theory which suggests that risk perceptions vary depending on the "frame of mind" evoked by the environment/context. Designers of warnings must be sensitive to the fact that product users' cognitive representations develop within a culture and that risk perceptions will vary based on the context in which they are derived. PMID:26360193

  2. Effects of culture (China vs. US) and task on perceived hazard: Evidence from product ratings, label ratings, and product to label matching.

    PubMed

    Lesch, Mary F; Rau, Pei-Luen Patrick; Choi, YoonSun

    2016-01-01

    In the current study, 44 Chinese and 40 US college students rated their perceived hazard in response to warning labels and products and attempted to match products with warning labels communicating the same level of hazard. Chinese participants tended to provide lower ratings of hazard in response to labels, but hazard perceived in response to products did not significantly differ as a function of culture. When asked to match a product with a warning label, Chinese participants' hazard perceptions appeared to be better calibrated, than did US participants', across products and labels. The results are interpreted in terms of constructivist theory which suggests that risk perceptions vary depending on the "frame of mind" evoked by the environment/context. Designers of warnings must be sensitive to the fact that product users' cognitive representations develop within a culture and that risk perceptions will vary based on the context in which they are derived.

  3. Perceived effectiveness of pictorial health warnings among Mexican youth and adults: a population-level intervention to reduce tobacco related inequities

    PubMed Central

    Hammond, David; Thrasher, James; Reid, Jessica L.; Driezen, Pete; Boudreau, Christian; Santillan, Edna Arillo

    2015-01-01

    Purpose Pictorial health warnings on cigarette packages are a prominent and effective means of communicating the risks of smoking; however, there is little research on effective types of message content and socio-demographic effects. This study tested message themes and content of pictorial warnings in Mexico. Methods Face-to-face surveys were conducted with 544 adult smokers and 528 youth in Mexico City. Participants were randomized to view 5–7 warnings for two of 15 different health effects. Warnings for each health effect included a text-only warning and pictorial warnings with various themes: “graphic” health effects, “lived experience”, symbolic images, and testimonials. Results Pictorial health warnings were rated as more effective than text-only warnings. Pictorial warnings featuring “graphic” depictions of disease were significantly more effective than symbolic images or experiences of human suffering. Adding testimonial information to warnings increased perceived effectiveness. Adults who were female, older, had lower education, and intended to quit smoking rated warnings as more effective, although the magnitude of these differences was modest. Few interactions were observed between socio-demographics and message theme. Conclusions Graphic depictions of disease were perceived by youth and adults as the most effective warning theme. Perceptions of warnings were generally similar across socio-demographic groups. PMID:22362058

  4. The Effects of Tobacco-Related Health-Warning Images on Intention to Quit Smoking among Urban Chinese Smokers

    ERIC Educational Resources Information Center

    Wu, Dan; Yang, Tingzhong; Cottrell, Randall R.; Zhou, Huan; Yang, Xiaozhao Y.; Zhang, Yanqin

    2015-01-01

    Objective: The purpose of this study was to explore the effects of different tobacco health-warning images on intention to quit smoking among urban Chinese smokers. The different tobacco health-warning images utilised in this study addressed the five variables of age, gender, cultural-appropriateness, abstractness and explicitness. Design:…

  5. Analysis of US Food and Drug Administration Warning Letters

    PubMed Central

    Salas, Maribel; Martin, Michelle; Pisu, Maria; McCall, Erin; Zuluaga, Alvaro; Glasser, Stephen P.

    2013-01-01

    Background Recent studies have suggested that there has been an increase in the number of ‘warning letters’ issued by the US Food and Drug Administration (FDA) despite the publication of the FDA advertising guidelines. However, limited information is available on the description of warning letters. The objective of this study was to analyse the frequency and content of FDA warning letters in relation to promotional claims and discuss the influence of regulatory and industry constraints on promotion. Methods All warning letters published by the FDA between 5 May 1995 and 11 June 2007 were reviewed. Warning letters related to promotional issues were included and analysed. Information related to the identification number, date of the warning letter, FDA division that issued the letter, drug name, manufacturer, specific warning problem, type of promotional material and requested action was extracted. Two independent investigators reviewed and classified each PDF file, any differences were discussed until a consensus was reached. Results Between May 1995 and June 2007 a total of 8692 warning letters were issued, of which 25% were related to drugs. Of these, 206 warning letters focused on drug promotion and were included in this study: 23% were issued in 2005, 15% in 2004 and 14% in 1998. In total, 47% of the warning letters were issued because of false or misleading unapproved doses and uses, 27% failed to disclose risks, 15% cited misleading promotion, 8% related to misleading labelling and 3% promoted false effectiveness claims. Discussion There is an important variation in the number of warning letters issued in the last decade, probably because of the increasing number of drugs approved by the FDA, drug withdrawal scandals, and the publication of the FDA and the Pharmaceutical Research and Manufacturers of America (PhRMA) guidelines. Conclusion We found that benefit-related claims, such as unapproved uses or doses of drugs, and failure to disclose risks, are the

  6. Tobacco industry argues domestic trademark laws and international treaties preclude cigarette health warning labels, despite consistent legal advice that the argument is invalid

    PubMed Central

    Crosbie, Eric; Glantz, Stanton A

    2013-01-01

    Objectives To analyse the tobacco industry’s use of international trade agreements to oppose policies to strengthen health warning labels (HWLs). Design A review of tobacco industry documents, tobacco control legislation and international treaties. Results During the early 1990s, the tobacco industry became increasingly alarmed about the advancement of HWLs on cigarettes packages. In response, it requested legal opinions from British American Tobacco’s law firms in Australia and England, Britain’s Department of Trade and Industry and the World Intellectual Property Organisation on the legality of restricting and prohibiting the use of their trademarks, as embodied in cigarette packages. The consistent legal advice, privately submitted to the companies, was that international treaties do not shield trademark owners from government limitations (including prohibition) on the use of their trademarks. Despite receiving this legal advice, the companies publicly argued that requiring large HWLs compromised their trademark rights under international treaties. The companies successfully used these arguments as part of their successful effort to deter Canadian and Australian governments from enacting laws requiring the plan packaging of cigarettes, which helped delay large graphic HWLs, including ‘plain’ packaging, for over a decade. Conclusions Governments should not be intimidated by tobacco company threats and unsubstantiated claims, and carefully craft HWL laws to withstand the inevitable tobacco industry lawsuits with the knowledge that the companies’ own lawyers as well as authoritative bodies have told the companies that the rights they claim do not exist. PMID:23179728

  7. 21 CFR 1302.05 - Effective dates of labeling requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Effective dates of labeling requirements. 1302.05 Section 1302.05 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE LABELING AND PACKAGING REQUIREMENTS FOR CONTROLLED SUBSTANCES § 1302.05 Effective dates of labeling requirements....

  8. 21 CFR 1302.05 - Effective dates of labeling requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Effective dates of labeling requirements. 1302.05 Section 1302.05 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE LABELING AND PACKAGING REQUIREMENTS FOR CONTROLLED SUBSTANCES § 1302.05 Effective dates of labeling requirements....

  9. Effects of Funding Policy Changes and Health Warnings on the Use of Erythropoiesis-Stimulating Agents

    PubMed Central

    Weir, Matthew A.; Gomes, Tara; Winquist, Eric; Juurlink, David N.; Cuerden, Meaghan S.; Mamdani, Muhammad

    2012-01-01

    Purpose: To characterize the effects of formulary changes and governmental safety warnings on use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. Patients and Methods: We conducted a cross-sectional time-series analysis using health administrative data from Ontario, Canada. From January 1997 to December 2009 we identified all ESA initiations among patients diagnosed with cancer. We explored the effects of two formulary changes that progressively liberalized coverage for ESAs, first by rescinding the requirement for blood transfusion in 2003 and then by removing all restrictions in 2007. We also explored the effect of US Food and Drug Administration and Health Canada warnings issued in the second quarter of 2007. To assess regional variability in ESA use, we determined prescription rates for each of Ontario's 14 regional cancer centers. Results: After the first formulary change, the ESA initiation rate increased to 1.66 new users per 1,000 patients with cancer, 374% more than predicted (P < .001). After the second formulary change, the initiation rate increased to 3.97 new users per 1,000 patients with cancer, 73% more than predicted (P < .001). After the safety warnings, this rate declined 81% by study end (P < .001). We found significant regional variation in ESA use. Conclusion: Formulary access and safety warnings had significant impacts on the new use of ESA drugs in patients with cancer. This suggests that both are effective means of influencing the use of these drugs. Variable ESA prescription rates across our region may reflect a lack of consensus regarding their utility. PMID:22942813

  10. Memory Saves Lives: Inter-generational Warnings Effectiveness - 13556

    SciTech Connect

    Van Luik, Abraham; Patterson, Russell; Shafer, David; Klein, Thomas

    2013-07-01

    The 2011 Tohoku earthquake and tsunami was a world-class natural disaster. It has been described as the most powerful earthquake ever in Japan, and as one of the most powerful earthquakes ever noted in the world. The toll in terms of human lives lost and property destruction was unimaginable. Even the word 'horrible' is inadequate to describe the suffering and misery that resulted. Nations with nuclear power programs are engaged in, or at least planning to become engaged in, arranging to eventually dispose of their higher-level radioactive waste materials in deep geologic repositories. Geologic repositories are passive safety systems, and if undisturbed isolate these dangerous materials form the biosphere for extremely long times. The key words, however, are 'if undisturbed'. To assure that future generations do not inadvertently drill into repositories, national programs, and the international community (the Records, Knowledge and Memory (RK and M) preservation project of the Nuclear Energy Agency, for example), are proposing to place markers and/or monuments on closed repository sites that say 'do not drill here, and this is why' in various sophisticated ways. Such markers or monuments are attempts at providing passive institutional controls. The effectiveness of messages from past generations to a present generation may give an indication of how effective such passive institutional controls may be. (authors)

  11. The Fetal Alcohol Syndrome Public Awareness Campaign, 1979: Progress Report Concerning the Advance Notice of Proposed Rulemaking on Warning Labels on Containers of Alcoholic Beverages and Addendum.

    ERIC Educational Resources Information Center

    Department of the Treasury, Washington, DC.

    This report provides expert opinion on the problems of fetal alcohol syndrome (FAS) and ways to inform the public of teratogenic risk of alcohol consumption during pregnancy. In the absence of firm evidence that moderate drinking of alcoholic beverages leads to FAS and uncertainty concerning the effectiveness of labeling of alcoholic beverages, a…

  12. Effectiveness of a Forward Collision Warning System in simple and in dual task from an electrophysiological perspective.

    PubMed

    Bueno, Mercedes; Fort, Alexandra; Francois, Mathilde; Ndiaye, Daniel; Deleurence, Philippe; Fabrigoule, Colette

    2013-04-29

    Forward Collision Warning Systems (FCWS) are expected to assist drivers; however, it is not completely clear whether these systems are of benefit to distracted drivers as much as they are to undistracted drivers. This study aims at investigating further the analysis of the effectiveness of a surrogate FCWS according to the attentional state of participants. In this experiment electrophysiological and behavioural data were recording while participants were required to drive in a simple car simulator and to react to the braking of the lead vehicle which could be announced by a warning system. The effectiveness of this warning system was evaluated when drivers were distracted or not by a secondary cognitive task. In a previous study, the warning signal was not completely effective likely due to the presence of another predictor of the forthcoming braking which competes with the warning. By eliminating this secondary predictor in the present study, the results confirmed the negative effect of the secondary task and revealed the expected effectiveness of the warning system at behavioural and electrophysiological levels.

  13. Smokers’ and E-Cigarette Users’ Perceptions about E-Cigarette Warning Statements

    PubMed Central

    Wackowski, Olivia A.; Hammond, David; O’Connor, Richard J.; Strasser, Andrew A.; Delnevo, Cristine D.

    2016-01-01

    Cigarette warning labels are important sources of risk information, but warning research for other tobacco products is limited. This study aimed to gauge perceptions about warnings that may be used for e-cigarettes. We conducted six small focus groups in late 2014/early 2015 with adult current e-cigarette users and cigarette-only smokers. Participants rated and discussed their perceptions of six e-cigarette warning statements, and warnings in two existing Vuse and MarkTen e-cigarette ads. Participants were open to e-cigarette warnings and provided the strongest reactions to statements warning that e-liquid/e-vapor or e-cigarettes can be poisonous, contain toxins, or are “not a safe alternative to smoking”. However, many also noted that these statements were exaggerated, potentially misleading, and could scare smokers away from reducing their harm by switching to e-cigarettes. Opinions on the Food and Drug Administration’s proposed nicotine addiction warning and warnings that e-cigarettes had not been approved for smoking cessation or had unknown health effects were mixed. Participants perceived MarkTen’s advertisement warning to be stronger and more noticeable than Vuse’s. Care should be taken in developing e-cigarette warnings given their relative recentness and potential for harm reduction compared to other tobacco products. Additional research, including with varied audiences, would be instructive. PMID:27376310

  14. Smokers' and E-Cigarette Users' Perceptions about E-Cigarette Warning Statements.

    PubMed

    Wackowski, Olivia A; Hammond, David; O'Connor, Richard J; Strasser, Andrew A; Delnevo, Cristine D

    2016-01-01

    Cigarette warning labels are important sources of risk information, but warning research for other tobacco products is limited. This study aimed to gauge perceptions about warnings that may be used for e-cigarettes. We conducted six small focus groups in late 2014/early 2015 with adult current e-cigarette users and cigarette-only smokers. Participants rated and discussed their perceptions of six e-cigarette warning statements, and warnings in two existing Vuse and MarkTen e-cigarette ads. Participants were open to e-cigarette warnings and provided the strongest reactions to statements warning that e-liquid/e-vapor or e-cigarettes can be poisonous, contain toxins, or are "not a safe alternative to smoking". However, many also noted that these statements were exaggerated, potentially misleading, and could scare smokers away from reducing their harm by switching to e-cigarettes. Opinions on the Food and Drug Administration's proposed nicotine addiction warning and warnings that e-cigarettes had not been approved for smoking cessation or had unknown health effects were mixed. Participants perceived MarkTen's advertisement warning to be stronger and more noticeable than Vuse's. Care should be taken in developing e-cigarette warnings given their relative recentness and potential for harm reduction compared to other tobacco products. Additional research, including with varied audiences, would be instructive. PMID:27376310

  15. 21 CFR 1302.05 - Effective dates of labeling requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PACKAGING REQUIREMENTS FOR CONTROLLED SUBSTANCES § 1302.05 Effective dates of labeling requirements. All... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Effective dates of labeling requirements. 1302.05..., on or before the effective date established in the final order for the transfer or addition....

  16. Smokers' recall of Australian graphic cigarette packet warnings & awareness of associated health effects, 2005-2008

    PubMed Central

    2011-01-01

    Background In 2006, Australia introduced graphic cigarette packet warnings. The new warnings include one of 14 pictures, many depicting tobacco-related pathology. The warnings were introduced in two sets; Set A in March and Set B from November. This study explores their impact on smokers' beliefs about smoking related illnesses. This study also examines the varying impact of different warnings, to see whether warnings with visceral images have greater impact on smokers' beliefs than other images. Methods Representative samples of South Australian smokers were interviewed in four independent cross-sectional omnibus surveys; in 2005 (n = 504), 2006 (n = 525), 2007 (n = 414) and 2008 (n = 464). Results Unprompted recall of new graphic cigarette warnings was high in the months following their introduction, demonstrating that smokers' had been exposed to them. Smokers also demonstrated an increase in awareness about smoking-related diseases specific to the warning messages. Warnings that conveyed new information and had emotive images demonstrated greater impact on recall and smokers' beliefs than more familiar information and less emotive images. Conclusions Overall graphic pack warnings have had the intended impact on smokers. Some have greater impact than others. The implications for policy makers in countries introducing similar warnings are that fresh messaging and visceral images have the greatest impact. PMID:21496314

  17. 21 CFR 740.2 - Conspicuousness of warning statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.2 Conspicuousness of warning... exemption pursuant to paragraph (b) of this section is established. (b) If the label of any cosmetic...

  18. 21 CFR 740.2 - Conspicuousness of warning statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.2 Conspicuousness of warning... exemption pursuant to paragraph (b) of this section is established. (b) If the label of any cosmetic...

  19. 21 CFR 740.2 - Conspicuousness of warning statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.2 Conspicuousness of warning... exemption pursuant to paragraph (b) of this section is established. (b) If the label of any cosmetic...

  20. 21 CFR 740.2 - Conspicuousness of warning statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.2 Conspicuousness of warning... exemption pursuant to paragraph (b) of this section is established. (b) If the label of any cosmetic...

  1. 21 CFR 740.2 - Conspicuousness of warning statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.2 Conspicuousness of warning... exemption pursuant to paragraph (b) of this section is established. (b) If the label of any cosmetic...

  2. Selection of a voice for a speech signal for personalized warnings: the effect of speaker's gender and voice pitch.

    PubMed

    Machado, Sheron; Duarte, Emília; Teles, Júlia; Reis, Lara; Rebelo, Francisco

    2012-01-01

    There is an increasing interest in multimodal technology-based warnings, namely those conveying speech-warning statements. This type of warning may be tailored to the situation as well as to the target user's characteristics. However, more information is needed on how to design these warnings in a way that ensures intelligibility, promotes compliance and reduces the potential for annoyance. In this context, this paper reports an exploratory study whose main purpose was to assist the selection of a synthesized voice for a subsequent compliance study with personalized (i.e., using the person's name) technology-based warnings using Virtual Reality. Participants were requested to listen to speech signals, gathered from a speech synthesizer and post-processed in order to change the pitch perception, and then these were evaluated by fulfilling the MOS-X questionnaire. After that, the participants ranked the voices according to their preference. The effects of the speaker's gender and voice pitch, on both ratings and ranking were assessed. The preference of the male and female listeners for a talker's voice gender was also investigated. The results show that participants mostly prefer as first choice the high-pitched female voice, which also gathered the highest overall score in the MOS-X questionnaire. No significant influence of the participants' gender was found on the assessed measures.

  3. A qualitative exploration of young adult smokers’ responses to novel tobacco warnings

    PubMed Central

    2013-01-01

    Background Despite reduced smoking among adolescents, smoking prevalence peaks among young adults aged 18–30, many of whom believe themselves exempt from the health risks of smoking shown in warning labels. We explored how young adult smokers perceived warnings featuring proximal risks, and whether these encouraged cessation more effectively than traditional health messages. Methods We conducted in-depth interviews with 17 young adult smokers and explored their perceptions of current warnings as well as novel warnings representing short-term health consequences; immediate social risks, and tobacco’s toxicity (denormalizing tobacco as an everyday product). We used a thematic analysis approach to explore how participants rationalized existing warnings and interpreted the novel messages. Results Participants considered the immediate social and physiological benefits they gained from smoking outweighed the distal risks shown in health warnings, which they regarded as improbable and irrelevant. Of the novel warnings, those presenting immediate social risks altered the balance of gains and losses young adults associated with smoking; however, those presenting short-term health risks or depicting tobacco as a toxin were less effective. Conclusions Participants regarded warnings featuring proximal social risks as more salient and they were less likely to rationalise these as irrelevant. Social risk messages merit further investigation to examine their potential as a complement to traditional health warnings. PMID:23800292

  4. The Effects of Truncated Dome Detectable Warnings on Travelers Negotiating Curb Ramps in Wheelchairs

    ERIC Educational Resources Information Center

    Lee, Helen

    2011-01-01

    Truncated domes on curb ramps benefit travelers with visual impairments. However, concerns associated with the safety and negotiability of such detectable warnings for other travelers have resulted in much controversy. The findings of the study presented here indicate that detectable warnings did not adversely affect the negotiability of ramps by…

  5. Systematic Review of the Effect of Pictorial Warnings on Cigarette Packages in Smoking Behavior

    PubMed Central

    Liu, Bojing; Greiner, Felix; Bremberg, Sven; Galanti, Rosaria

    2014-01-01

    We used a structured approach to assess whether active smokers presented with pictorial warnings on cigarette packages (PWCP) had a higher probability of quitting, reducing, and attempting to quit smoking than did unexposed smokers. We identified 21 articles from among nearly 2500 published between 1993 and 2013, prioritizing coverage over relevance or quality because we expected to find only a few studies with behavioral outcomes. We found very large heterogeneity across studies, poor or very poor methodological quality, and generally null or conflicting findings for any explored outcome. The evidence for or against the use of PWCP is insufficient, suggesting that any effect of PWCP on behavior would be modest. Determining the single impact of PWCP on behavior requires studies with strong methodological designs and longer follow-up periods. PMID:25122019

  6. Impact of Waterpipe Tobacco Pack Health Warnings on Waterpipe Smoking Attitudes: A Qualitative Analysis among Regular Users in London

    PubMed Central

    Jawad, Mohammed; Bakir, Ali; Ali, Mohammed; Grant, Aimee

    2015-01-01

    Background. Despite the rise in prevalence of waterpipe tobacco smoking, it has received little legislative enforcement from governing bodies, especially in the area of health warning labels. Methods. Twenty regular waterpipe tobacco smokers from London took part in five focus groups discussing the impact of waterpipe tobacco pack health warnings on their attitudes towards waterpipe smoking. We presented them with existing and mock waterpipe tobacco products, designed to be compliant with current and future UK/EU legislation. Data were analysed using thematic analysis. Results. Participants felt packs were less attractive and health warnings were more impactful as health warnings increased in size and packaging became less branded. However, participants highlighted their lack of exposure to waterpipe tobacco pack health warnings due to the inherent nature of waterpipe smoking, that is, smoking in a café with the apparatus already prepacked by staff. Health warnings at the point of consumption had more reported impact than health warnings at the point of sale. Conclusions. Waterpipe tobacco pack health warnings are likely to be effective if compliant with existing laws and exposed to end-users. Legislations should be reviewed to extend health warning labels to waterpipe accessories, particularly the apparatus, and to waterpipe-serving premises. PMID:26273642

  7. An evaluation of warning habits and beliefs across the adult life span.

    PubMed

    Hancock, H E; Rogers, W A; Fisk, A D

    2001-01-01

    Beliefs about warnings and habits associated with reading them were assessed for 863 individuals of various ages. Information gathered for various common household products included (a) how frequently people attend to warning information, (b) the degree of risk they believe is involved during product usage, and (c) how important they believe warnings are for different product types. Also assessed were perceived helpfulness and comprehension for symbols commonly found on product labels or on signs in the environment. Respondents 55 years and older reported reading product warnings more frequently than did younger adults, although they generally perceived warnings as less important. However, no overall age-related differences were found for perceived level of risk involved in using different product types. Although older adults generally perceived symbols to be very helpful when using a particular product, their comprehension levels were poorer than those of younger adults for half of the symbols. Overall, these data suggest that adults of all ages do read warnings on a variety of product types and that they believe warning information is important. This research illustrates the importance of including older adults in usability studies during the development of warning systems, given age-related effects may be associated with some aspects of the warning processing but not others. PMID:11866191

  8. Effect of different children's menu labeling designs on family purchases.

    PubMed

    Holmes, Ashley S; Serrano, Elena L; Machin, Jane E; Duetsch, Thomas; Davis, George C

    2013-03-01

    The majority of labeling studies at restaurants have focused on adults, not children, and utilized cross-sectional data with one menu labeling design, typically calorie information. The aim of this longitudinal study was to examine the effect of three different menu labeling designs for children's meals on total calories and fat selected by families. Each menu was implemented for 2months. Patrons' purchases were tracked from a control menu (with no nutrition information) through all three theoretically-based designs: calorie and fat information; followed by symbols denoting healthier choices; then nutrition bargain price. All menus were created specifically for the study. They featured six combination meals (pre-determined entrees and side items) and a la carte items (entrees and side items that could be ordered separately). Only combination meals contained labeling. Fixed effects models were estimated to detect changes in sales for each menu labeling design compared to the control. Overall, menu labeling did not result in a positive net effect on total calories or fat purchased by families, but resulted in significant shifts in purchases of combination and a la carte meals and healthy and unhealthy options. The most significant impact was seen for nutrition bargain price labeling, the last design.

  9. 21 CFR 1141.10 - Required warnings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PRODUCTS CIGARETTE PACKAGE AND ADVERTISING WARNINGS; (Eff. 9-22-12) Cigarette Package and Advertising... cigarettes the package of which fails to bear, in accordance with section 4 of the Federal Cigarette Labeling... “Cigarette Required Warnings,” which is incorporated by reference at § 1141.12, and accurately reproduced...

  10. 21 CFR 1141.10 - Required warnings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PRODUCTS CIGARETTE PACKAGE AND ADVERTISING WARNINGS Cigarette Package and Advertising Warnings § 1141.10..., offer to sell, distribute, or import for sale or distribution within the United States any cigarettes the package of which fails to bear, in accordance with section 4 of the Federal Cigarette Labeling...

  11. 21 CFR 1141.10 - Required warnings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PRODUCTS CIGARETTE PACKAGE AND ADVERTISING WARNINGS Cigarette Package and Advertising Warnings § 1141.10..., offer to sell, distribute, or import for sale or distribution within the United States any cigarettes the package of which fails to bear, in accordance with section 4 of the Federal Cigarette Labeling...

  12. Framing unauthorized immigrants: the effects of labels on evaluations.

    PubMed

    Ommundsen, Reidar; Van der Veer, Kees; Larsen, Knud S; Eilertsen, Dag-Erik

    2014-04-01

    In the U.S. media, unauthorized immigrants are often interchangeably referred to as "illegal aliens," "illegal immigrants," and undocumented immigrants." In spite of formal equivalence, these terms carry different connotations, but the effects of these labels on people's attitudes toward immigrants are not well documented. In this replication study, 274 undergraduate students in psychology responded to one of three randomly distributed versions of a 20-item scale measuring attitudes toward unauthorized immigration. The items in the three scale versions varyingly referred to immigrants using the three terms. Results showed differences in attitudes toward unauthorized immigration between all experimental conditions. The label "illegal immigrants" yielded significantly less positive attitudes compared to the label "undocumented immigrants," and respondents exposed to the label "illegal aliens" showed the most positive attitudes. Furthermore, the effects of the experimental conditions were not moderated by the respondents' patriotism, sex, or own immigrant background.

  13. 21 CFR 740.1 - Establishment of warning statements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.1 Establishment of warning statements. (a) The label of a cosmetic product shall bear a warning statement whenever necessary or appropriate to prevent... for a cosmetic. Any such petition shall include an adequate factual basis to support the...

  14. 21 CFR 740.1 - Establishment of warning statements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.1 Establishment of warning statements. (a) The label of a cosmetic product shall bear a warning statement whenever necessary or appropriate to prevent... for a cosmetic. Any such petition shall include an adequate factual basis to support the...

  15. 21 CFR 740.1 - Establishment of warning statements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.1 Establishment of warning statements. (a) The label of a cosmetic product shall bear a warning statement whenever necessary or appropriate to prevent... for a cosmetic. Any such petition shall include an adequate factual basis to support the...

  16. 21 CFR 740.1 - Establishment of warning statements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.1 Establishment of warning statements. (a) The label of a cosmetic product shall bear a warning statement whenever necessary or appropriate to prevent... for a cosmetic. Any such petition shall include an adequate factual basis to support the...

  17. 21 CFR 740.1 - Establishment of warning statements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS General § 740.1 Establishment of warning statements. (a) The label of a cosmetic product shall bear a warning statement whenever necessary or appropriate to prevent... for a cosmetic. Any such petition shall include an adequate factual basis to support the...

  18. A cross-sectional survey investigating the desensitisation of graphic health warning labels and their impact on smokers, non-smokers and patients with COPD in a London cohort

    PubMed Central

    Ratneswaran, Culadeeban; Chisnall, Ben; Drakatos, Panagis; Sivakumar, Sukhanthan; Sivakumar, Bairavie; Barrecheguren, Miriam; Douiri, Abdel; Steier, Joerg

    2014-01-01

    Objectives There is a lack of evidence regarding the effectiveness of graphic health warning labels (GHWL) in different individuals, including patients with chronic obstructive pulmonary disease (COPD). Investigating knowledge and attitudes may allow better implementation of future public health policies. We hypothesised that differences in the impact of GHWL exist between non-smokers, smokers and patients with COPD, with decreased efficacy in those groups who are longer and more frequently exposed to them. Participants and setting 163 participants (54% male, aged 21–80) including 60 non-smokers, 53 smokers and 50 patients with COPD (Gold stage II–IV), attending London respiratory outpatient clinics, participated in case-controlled surveys (50 items). Outcome measures Ten different GHWL were shown and demographics, smoking history, plans to quit, smoking-risk awareness, emotional response, processing and impact of GHWL on behaviour were recorded. Patients were further asked to prioritise the hypothetical treatment or prevention of five specific smoking-related diseases. Results Smokers, in particular those with COPD, were less susceptible to GHWL than non-smokers; 53.4% of all participants expressed fear when looking at GHWL, non-smokers (71.9%) more so than smokers (39.8%, p<0.001). COPD participants were less aware of the consequences than non-COPD participants (p<0.001), including an awareness of lung cancer (p=0.001). Lung cancer (95%), oral cancer (90.2%), heart disease (84.7%) and stroke (71.2%) were correctly associated with smoking, whereas blindness was least associated (23.9%). However, blindness was prioritised over oral cancer, stroke and in patients with COPD also over heart disease when participants were asked about hypothetical treatment or prevention. Conclusions GHWL are most effective in non-smokers and a desensitisation effect was observed in smokers and patients with COPD. As a consequence, a tailored and concerted public health approach to

  19. PILOT RESULTS ON FORWARD COLLISION WARNING SYSTEM EFFECTIVENESS IN OLDER DRIVERS

    PubMed Central

    Lester, Benjamin D.; Sager, Lauren N.; Dawson, Jeffrey; Hacker, Sarah D.; Aksan, Nazan; Rizzo, Matthew; Kitazaki, Satoshi

    2016-01-01

    Summary Advanced Driver Assistance Systems (ADAS) have largely been developed with a “one-size-fits-all” approach. This approach neglects the large inter-individual variability in perceptual and cognitive abilities that affect aging ADAS users. We investigated the effectiveness of a forward collision warning (FCW) with fixed response parameters in young and older drivers with differing levels of cognitive functioning. Drivers responded to a pedestrian stepping into the driver’s path on a simulated urban road. Behavioral metrics included response times (RT) for pedal controls and two indices of risk penetration (e.g., maximum deceleration and minimum time-to-collision (TTC)). Older drivers showed significantly slower responses at several time points compared to younger drivers. The FCW facilitated response times (RTs) for older and younger drivers. However, older drivers still showed smaller safety gains compared to younger drivers at accelerator pedal release and initial brake application when the FCW was active. No significant differences in risk metrics were observed within the condition studied. The results demonstrate older drivers likely differ from younger drivers using a FCW with a fixed parameter set. Finally, we briefly discuss how future research should examine predictive relationships between domains of cognitive functioning and ADAS responses to develop parameter sets to fit the individual. PMID:27135061

  20. Emergency warning systems. Part 2. Warning systems - evaluation guidelines. Final report 1982-1983

    SciTech Connect

    Tanczos, R.C.; Kanen, A.C.

    1983-07-01

    This report is the result of research performed to establish guidelines for warning systems as they are used for natural disasters, nuclear power plant accidents, or nuclear attacks. The warning systems include both fixed and mobile sirens, tone alert radios, telephone systems, power line devices. Communications systems that control these warning systems are discussed. Test results of several warning systems are included along with a discussion of sound propagation, hearing, and other items that concern the effectiveness of warning systems.

  1. [Pictorial health warnings on tobacco products packages as a part of tobacco epidemic control].

    PubMed

    Kaleta, Dorota; Kozieł, Anna; Miśkiewicz, Paulina

    2009-01-01

    The use of tobacco products has been described by the World Health Organization as the risk factor responsible for six out of eight causes of death in the world. Informing about the harm of smoking may be presented in many ways like media campaigns, text warnings, or graphic warnings placed on tobacco products. The aim of this article is to describe the role of graphic warnings placed on tobacco products in light of tobacco control. In this work, the available current data, including researches and reports of WHO, have been used. Graphic warnings may be a very valuable source of knowledge about health consequences of smoking. They are also much more visible, draw attention much better compared with text warnings and more clearly communicate the threats of tobacco use. They also have a stronger impact, are better memorized and better motivate to quit smoking. Pictorial warnings are also approved by the society. Smokers themselves perceive them as more effective than text warnings. Moreover, this kind of labeling makes tobacco products less attractive. The introduction of legal regulations enforcing these types of warnings does not cost anybody but the tobacco companies. This kind of solution helps to gain public acceptance for other methods of tobacco control like totally free tobacco smoke places. PMID:19999044

  2. [Pictorial health warnings on tobacco products packages as a part of tobacco epidemic control].

    PubMed

    Kaleta, Dorota; Kozieł, Anna; Miśkiewicz, Paulina

    2009-01-01

    The use of tobacco products has been described by the World Health Organization as the risk factor responsible for six out of eight causes of death in the world. Informing about the harm of smoking may be presented in many ways like media campaigns, text warnings, or graphic warnings placed on tobacco products. The aim of this article is to describe the role of graphic warnings placed on tobacco products in light of tobacco control. In this work, the available current data, including researches and reports of WHO, have been used. Graphic warnings may be a very valuable source of knowledge about health consequences of smoking. They are also much more visible, draw attention much better compared with text warnings and more clearly communicate the threats of tobacco use. They also have a stronger impact, are better memorized and better motivate to quit smoking. Pictorial warnings are also approved by the society. Smokers themselves perceive them as more effective than text warnings. Moreover, this kind of labeling makes tobacco products less attractive. The introduction of legal regulations enforcing these types of warnings does not cost anybody but the tobacco companies. This kind of solution helps to gain public acceptance for other methods of tobacco control like totally free tobacco smoke places.

  3. Designing informative warning signals: Effects of indicator type, modality, and task demand on recognition speed and accuracy.

    PubMed

    Stevens, Catherine J; Brennan, David; Petocz, Agnes; Howell, Clare

    2009-01-01

    An experiment investigated the assumption that natural indicators which exploit existing learned associations between a signal and an event make more effective warnings than previously unlearned symbolic indicators. Signal modality (visual, auditory) and task demand (low, high) were also manipulated. Warning effectiveness was indexed by accuracy and reaction time (RT) recorded during training and dual task test phases. Thirty-six participants were trained to recognize 4 natural and 4 symbolic indicators, either visual or auditory, paired with critical incidents from an aviation context. As hypothesized, accuracy was greater and RT was faster in response to natural indicators during the training phase. This pattern of responding was upheld in test phase conditions with respect to accuracy but observed in RT only in test phase conditions involving high demand and the auditory modality. Using the experiment as a specific example, we argue for the importance of considering the cognitive contribution of the user (viz., prior learned associations) in the warning design process. Drawing on semiotics and cognitive psychology, we highlight the indexical nature of so-called auditory icons or natural indicators and argue that the cogniser is an indispensable element in the tripartite nature of signification.

  4. The Effectiveness of Reverse Telephon Emergency Warning Systems in the October 2007 San Diego Wildfires

    SciTech Connect

    Sorensen, John H; Sorensen, Barbara Vogt

    2009-01-01

    Late in October, 2007, fast-moving wildfires fueled by extreme Santa Ana winds threatened residents and their properties in San Diego County, California. The impacted area also included the City of San Diego within the County s boundaries. It turns out the San Diego firestorms would be the biggest in the County's history, surpassing the devastating 2003 firestorms in intensity, duration, and impacted populations. Both San Diego County and the City of San Diego have installed telephone reverse call-down emergency warning systems. A telephone survey of 1200 households located in areas identified by emergency officials as the evacuation zones for the 2007 fires was conducted in late March and early April 2008 using a random telephone dialing process to determine if people responded to the reverse telephone warning systems calls. Findings indicate that those who received a reverse emergency warning call were much more likely to evacuate than those who did not receive a call. The telephone calls were also the most likely source of first warning.

  5. Representation, Exemplification, and Risk: Resonance of Tobacco Graphic Health Warnings Across Diverse Populations.

    PubMed

    Bigman, Cabral A; Nagler, Rebekah H; Viswanath, K

    2016-08-01

    As countries implement Article 11 of the World Health Organization (WHO) Framework Convention on Tobacco Control, graphic warning labels that use images of people and their body parts to illustrate the consequences of smoking are being added to cigarette packs. According to exemplification theory, these case examples-exemplars-can shape perceptions about risk and may resonate differently among demographic subpopulations. Drawing on data from eight focus groups (N = 63) with smokers and nonsmokers from vulnerable populations, this qualitative study explores whether people considered exemplars in their reactions to and evaluations of U.S. graphic health warning labels initially proposed by the Food and Drug Administration. Participants made reference to prior and concurrent mass media messages and exemplars during the focus groups and used demographic cues in making sense of the images on the warning labels. Participants were particularly sensitive to age of the exemplars and how it might affect label effectiveness and beliefs about smoking. Race and socioeconomic status also were salient for some participants. We recommend that exemplars and exemplification be considered when selecting and evaluating graphic health warnings for tobacco labels and associated media campaigns. PMID:26757354

  6. Sounding the Alert: Designing an Effective Voice for Earthquake Early Warning

    NASA Astrophysics Data System (ADS)

    Burkett, E. R.; Given, D. D.

    2015-12-01

    The USGS is working with partners to develop the ShakeAlert Earthquake Early Warning (EEW) system (http://pubs.usgs.gov/fs/2014/3083/) to protect life and property along the U.S. West Coast, where the highest national seismic hazard is concentrated. EEW sends an alert that shaking from an earthquake is on its way (in seconds to tens of seconds) to allow recipients or automated systems to take appropriate actions at their location to protect themselves and/or sensitive equipment. ShakeAlert is transitioning toward a production prototype phase in which test users might begin testing applications of the technology. While a subset of uses will be automated (e.g., opening fire house doors), other applications will alert individuals by radio or cellphone notifications and require behavioral decisions to protect themselves (e.g., "Drop, Cover, Hold On"). The project needs to select and move forward with a consistent alert sound to be widely and quickly recognized as an earthquake alert. In this study we combine EEW science and capabilities with an understanding of human behavior from the social and psychological sciences to provide insight toward the design of effective sounds to help best motivate proper action by alert recipients. We present a review of existing research and literature, compiled as considerations and recommendations for alert sound characteristics optimized for EEW. We do not yet address wording of an audible message about the earthquake (e.g., intensity and timing until arrival of shaking or possible actions), although it will be a future component to accompany the sound. We consider pitch(es), loudness, rhythm, tempo, duration, and harmony. Important behavioral responses to sound to take into account include that people respond to discordant sounds with anxiety, can be calmed by harmony and softness, and are innately alerted by loud and abrupt sounds, although levels high enough to be auditory stressors can negatively impact human judgment.

  7. Warning Signs After Birth

    MedlinePlus

    ... Pregnancy > Postpartum care > Warning signs after birth Warning signs after birth E-mail to a friend Please ... infection Postpartum bleeding Postpartum depression (PPD) What warning signs should you look for? Call your provider if ...

  8. Stroke Warning Signs

    MedlinePlus

    ... News Advocate Stroke Warning Signs Quiz Stroke Warning Signs and Symptoms THINK YOU ARE HAVING A STROKE? ... Learn more stroke signs and symptoms >>>> Stroke Warning Signs Hip-Hop F.A.S.T. Video Updated Guidelines ...

  9. Driving-Simulator-Based Test on the Effectiveness of Auditory Red-Light Running Vehicle Warning System Based on Time-To-Collision Sensor

    PubMed Central

    Yan, Xuedong; Xue, Qingwan; Ma, Lu; Xu, Yongcun

    2014-01-01

    The collision avoidance warning system is an emerging technology designed to assist drivers in avoiding red-light running (RLR) collisions at intersections. The aim of this paper is to evaluate the effect of auditory warning information on collision avoidance behaviors in the RLR pre-crash scenarios and further to examine the casual relationships among the relevant factors. A driving-simulator-based experiment was designed and conducted with 50 participants. The data from the experiments were analyzed by approaches of ANOVA and structural equation modeling (SEM). The collisions avoidance related variables were measured in terms of brake reaction time (BRT), maximum deceleration and lane deviation in this study. It was found that the collision avoidance warning system can result in smaller collision rates compared to the without-warning condition and lead to shorter reaction times, larger maximum deceleration and less lane deviation. Furthermore, the SEM analysis illustrate that the audio warning information in fact has both direct and indirect effect on occurrence of collisions, and the indirect effect plays a more important role on collision avoidance than the direct effect. Essentially, the auditory warning information can assist drivers in detecting the RLR vehicles in a timely manner, thus providing drivers more adequate time and space to decelerate to avoid collisions with the conflicting vehicles. PMID:24566631

  10. The effects of motorcycle helmets on hearing and the detection of warning signals

    NASA Astrophysics Data System (ADS)

    Van Moorhem, W. K.; Shepherd, K. P.; Magleby, T. D.; Torian, G. E.

    1981-07-01

    Measurements of the at-ear helmet-generated aerodynamic noise and helmet insertion loss were carried out for the two major types of motorcycle helmets. From these data and existing information on noise generation by flow around a bare head it was found that for quiet motorcycles at typical operating speeds a significant part of the riders at-ear noise is generated by the air flow. An assessment of the possibility of hearing damage was then carried out. It was found that only with extremely high usage would there be a significant risk of hearing damage for either the bare headed or helmeted rider. Helmets did, however, give significant protection. Detection of warning signals was then considered. It was found that under none of the conditions investigated here did the helmet put its wearer at a disadvantage compared with the bare headed rider, and at typical constant speeds the helmet gave a rider an advantage in the detection of warning signals.

  11. Standardised (plain) cigarette packaging increases attention to both text-based and graphical health warnings: experimental evidence

    PubMed Central

    Shankleman, M.; Sykes, C.; Mandeville, K.L.; Di Costa, S.; Yarrow, K.

    2015-01-01

    Objective To investigate whether standardised cigarette packaging increases the time spent looking at health warnings, regardless of the format of those warnings. Study design A factorial (two pack styles x three warning types) within-subject experiment, with participants randomised to different orders of conditions, completed at a university in London, UK. Methods Mock-ups of cigarette packets were presented to participants with their branded portion in either standardised (plain) or manufacturer-designed (branded) format. Health warnings were present on all packets, representing all three types currently in use in the UK: black & white text, colour text, or colour images with accompanying text. Gaze position was recorded using a specialised eye tracker, providing the main outcome measure, which was the mean proportion of a five-second viewing period spent gazing at the warning-label region of the packet. Results An opportunity sample of 30 (six male, mean age = 23) young adults met the following inclusion criteria: 1) not currently a smoker; 2) <100 lifetime cigarettes smoked; 3) gaze position successfully tracked for > 50% viewing time. These participants spent a greater proportion of the available time gazing at the warning-label region when the branded section of the pack was standardised (following current Australian guidelines) rather than containing the manufacturer's preferred design (mean difference in proportions = 0.078, 95% confidence interval 0.049 to 0.106, p < 0.001). There was no evidence that this effect varied based on the type of warning label (black & white text vs. colour text vs. colour image & text; interaction p = 0.295). Conclusions During incidental viewing of cigarette packets, young adult never-smokers are likely to spend more time looking at health warnings if manufacturers are compelled to use standardised packaging, regardless of the warning design. PMID:25542740

  12. The Effects of Band Labels on Evaluators' Judgments of Musical Performance

    ERIC Educational Resources Information Center

    Silvey, Brian A.

    2009-01-01

    This study investigates the effects of band labels on evaluators' judgments of musical performance. High school concert band members (n = 72), wind ensemble members ( n = 77), and band directors (n = 8) were randomly assigned to a band label or no label group. Only the band label group was given evaluation forms that specified the group playing…

  13. Breast cancer in Iran: need for greater women awareness of warning signs and effective screening methods

    PubMed Central

    Montazeri, Ali; Vahdaninia, Mariam; Harirchi, Iraj; Harirchi, Amir Mahmood; Sajadian, Akram; Khaleghi, Fatemeh; Ebrahimi, Mandana; Haghighat, Shahpar; Jarvandi, Soghra

    2008-01-01

    indicated that the women awareness of breast cancer warning signs (painless lump, retraction of nipple, and bloody discharge) and effective screening methods i.e. clinical examination, and mammography were very inadequate. Thus, health education programmes to rectify the lack of women awareness is urgently needed. Indeed the focus of primary health care providers should be to raise awareness about breast care among women and to encourage them to report any unusual changes in their breasts to their family or care physicians. PMID:19099595

  14. Effect of misoprostol and cimetidine on gastric cell labeling index

    SciTech Connect

    Fich, A.; Arber, N.; Sestieri, M.; Zajicek, G.; Rachmilewitz, D.

    1985-07-01

    The effect of misoprostol and cimetidine on gastric cell turnover was studied. Endoscopic biopsy specimens of fundic and antral mucosa were obtained from duodenal ulcer patients before and after 4 wk of therapy with cimetidine 1.2 g/day or misoprostol 800 micrograms/day. Biopsy specimens were incubated with (/sup 3/H)thymidine. Glandular column length and number of labeled cells were determined after autoradiography. There was no significant difference in column length of antral or fundic glands before or after therapy with cimetidine and misoprostol. The number of antral and fundic labeled cells was significantly decreased after misoprostol treatment (3.6 +/- 0.3 and 4.6 +/- 0.4, mean +/- SE), as opposed to their respective number before therapy (6.9 +/- 0.5 and 8.3 +/- 0.8) (p less than 0.01). On the other hand, after treatment with cimetidine, the number of antral and fundic labeled cells was significantly higher (11.8 +/- 0.9 and 7.5 +/- 1.0, respectively) as compared with their number before therapy (5.7 +/- 0.5 and 5.6 +/- 0.6, respectively). The decreased gastric cell turnover induced by misoprostol indicates that the trophic effect of prostanoids on gastric mucosa is not due to an increase in cellular kinetics. The increased gastric cell turnover induced by cimetidine may contribute to its therapeutic effect in peptic ulcer disease.

  15. Airburst warning and response

    NASA Astrophysics Data System (ADS)

    Boslough, Mark

    2014-10-01

    It is virtually certain (probability>99%) that the next destructive NEO event will be an airburst. Planetary defense is usually assumed to have the primary goal of maximizing the number of lives saved, but it can be argued that more emphasis should be placed on maximizing the probability of saving lives. For the latter goal, it is far more effective to create an early warning and civil defense plan than a mitigation plan that involves deflecting a large NEO. Because early warning and civil defense will almost certainly be needed long before the first deflection is ever required, the credibility of the planetary defense community and its recommendations will be put to its first serious test by an airburst. Successful response to an airburst event will make it much more likely that recommendations for mitigation by deflection will be accepted by decision makers and the public. Focusing more attention on the second goal will, as a side effect, benefit the primary goal.

  16. Category label effects on Chinese children's inductive inferences: modulation by perceptual detail and category specificity.

    PubMed

    Long, Changquan; Lu, Xiaoying; Zhang, Li; Li, Hong; Deák, Gedeon O

    2012-02-01

    Inductive generalization of novel properties to same-category or similar-looking objects was studied in Chinese preschool children. The effects of category labels on generalizations were investigated by comparing basic-level labels, superordinate-level labels, and a control phrase applied to three kinds of stimulus materials: colored photographs (Experiment 1), realistic line drawings (Experiment 2), and cartoon-like line drawings (Experiment 3). No significant labeling effects were found for photos and realistic drawings, but there were significant effects for cartoon-like drawings. Children made mostly (>70%) category-based inferences about photographs whether or not labels were provided (Experiment 1). Children showed a bias toward category-based inferences about realistic drawings (Experiment 2) but did so only when labels were provided. Finally, children made mostly appearance-based generalizations for cartoon-like drawings (Experiment 3). However, labels (basic or superordinate level) reduced appearance-based responses. Labeling effects did not depend on having identical labels; however, identical superordinate labels were more effective than different basic-level labels for the least informative stimuli (i.e., cartoons). Thus, labels sometimes confirm the identity of ambiguous items. This evidence of labeling effects in Mandarin-speaking Chinese children extends previous findings beyond English-speaking children and shows that the effects are not narrowly culture and language specific.

  17. 75 FR 9767 - Classification of Benzoyl Peroxide as Safe and Effective and Revision of Labeling to Drug Facts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ..., resorcinol monoacetate, salicylic acid and/or sulfur to meet OTC drug labeling content and format... resorcinol, resorcinol monoacetate, salicylic acid, and/or sulfur subject to 21 CFR part 333 is March 4, 2015..., resorcinol, resorcinol monoacetate, salicylic acid, and/or sulfur be relabeled. We revised the warnings...

  18. A Study on Estimation on Flood Warning Trigger Rainfall in medium and small Stream Affected by Urban Effects

    NASA Astrophysics Data System (ADS)

    Youngseok, Song; Moojong, Park; JungHo, Lee; HeeSup, Lee

    2013-04-01

    As extreme floods occur frequently in recent years due to global climate changes, an in sudden local flooding of great volume and short duration is becoming the significant danger and loss of life and property in the Korean Peninsula as well as most parts of the world. The desire for living without hazardous damages grows these days, the city strategy to make the safer community has become an issue. Previously most of flood prevention efforts have been made for relatively large watersheds near to channel flow. However, as economical development and the expansion of city near medium and small stream, human casualty and property by flood occurs frequently. Therefore, to reduce the damage of human lives and property by flood, we develop an assessment method for flood warning trigger rainfall considering urban effect. Considering complex land use, HEC-HMS is used for rural area and SWMM is adopted for sewer networks runoff. And relationship between runoff and stream water level, HEC-RAS is accompanied with runoff results. Proposed flood warning trigger rainfall assessment method shows good agreement with gauged data and could be used for another case to mitigate damage. Acknowledgement: "This research was supported by a grant [NEMA-NH-2011-45] from the Natural Hazard Mitigation Research Group, National Emergency Management Agency of Korea." Keyword: HEC-HMS, HEC-RAS, critical precipitation, medium and small stream

  19. Warning systems and public warning response

    SciTech Connect

    Sorensen, J.H.

    1993-09-01

    This background paper reviews current knowledge on warning systems and human response to warnings. It expands on an earlier paper prepared for a workshop on the Second Assessment on Natural Hazards, held in Estes Park, Colorado in July 1992. Although it has a North American perspective, many of the lessons learned are universally applicable. The paper addresses warning systems in terms of dissemination and does not cover physical science issues associated with prediction and forecast. Finally, it covers hazards with relatively short lead times -- 48 hours or less. It does not address topics such as long-term forecasts of earthquakes or volcanic eruptions or early famine warning systems.

  20. Embedded Alcohol Messages in Television Series: The Interactive Effect of Warnings and Audience Connectedness on Viewers' Alcohol Beliefs*

    PubMed Central

    RUSSELL, DALE W.; RUSSELL, CRISTEL ANTONIA

    2014-01-01

    Objective This research investigates whether warning viewers about the presence of embedded messages in the content of a television episode affects viewers' drinking beliefs and whether audi ence connectedness moderates the warning's impact. Method Two hun dred fifty college students participated in a laboratory experiment approximating a real-life television viewing experience. They viewed an actual television series episode containing embedded alcohol messages, and their subsequent beliefs about alcohol consequences were measured. Experimental conditions differed based on a 2 (Connectedness Level: low vs high) × 2 (Timing of the Warning: before or after the episode) × 2 (Emphasis of Warning: advertising vs health message) design. Connectedness was measured, and the timing and emphasis of the warnings were manipulated. The design also included a control condition where there was no warning. Results The findings indicate that warning view ers about embedded messages in the content of a program can yield sig nificant differences in viewers' beliefs about alcohol. However, the warning's impact differs depending on the viewers' level of connectedness to the program. In particular, in comparison with the no-warning control condition, the advertising prewarning produced lower positive beliefs about alcohol and its consequences but only for the low-connected viewers. Highly connected viewers were not affected by a warning emphasizing advertising messages embedded in the program, but a warning emphasizing health produced significantly higher negative be liefs about drinking than in the control condition. Conclusions The presence of many positive portrayals of drinking and alcohol product placements in television series has led many to suggest ways to counter their influence. However, advocates of warnings should be conscious of their differential impact on high- and low-connected viewers. PMID:18432390

  1. Desire versus Efficacy in Smokers’ Paradoxical Reactions to Pictorial Health Warnings for Cigarettes

    PubMed Central

    Romer, Daniel; Peters, Ellen; Strasser, Andrew A.; Langleben, Daniel

    2013-01-01

    Pictorial health warnings on cigarette packs create aversive emotional reactions to smoking and induce thoughts about quitting; however, contrary to models of health behavior change, they do not appear to alter intentions to quit smoking. We propose and test a novel model of intention to quit an addictive habit such as smoking (the efficacy-desire model) that can explain this paradoxical effect. At the core of the model is the prediction that self-efficacy and desire to quit an addictive habit are inversely related. We tested the model in an online experiment that randomly exposed smokers (N = 3297) to a cigarette pack with one of three increasing levels of warning intensity. The results supported the model’s prediction that despite the effects of warnings on aversion to smoking, intention to quit smoking is an inverted U-shape function of the smoker’s self-efficacy for quitting. In addition, smokers with greater (lesser) quit efficacy relative to smoking efficacy increase (decrease) intentions to quit. The findings show that previous failures to observe effects of pictorial warning labels on quit intentions can be explained by the contradictory individual differences that warnings produce. Thus, the model explains the paradoxical finding that quit intentions do not change at the population level, even though smokers recognize the implications of warnings. The model suggests that pictorial warnings are effective for smokers with stronger quit-efficacy beliefs and provides guidance for how cigarette warnings and tobacco control strategies can be designed to help smokers quit. PMID:23383006

  2. 40 CFR 82.108 - Placement of warning statement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Placement of warning statement. 82.108 Section 82.108 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE The Labeling of Products Using Ozone-Depleting Substances § 82.108 Placement of warning statement....

  3. Automaticity of basic-level categorization accounts for labeling effects in visual recognition memory.

    PubMed

    Richler, Jennifer J; Gauthier, Isabel; Palmeri, Thomas J

    2011-11-01

    Are there consequences of calling objects by their names? Lupyan (2008) suggested that overtly labeling objects impairs subsequent recognition memory because labeling shifts stored memory representations of objects toward the category prototype (representational shift hypothesis). In Experiment 1, we show that processing objects at the basic category level versus exemplar level in the absence of any overt labeling produces the same qualitative pattern of results. Experiment 2 demonstrates that labeling does not always disrupt memory as predicted by the representational shift hypothesis: Differences in memory following labeling versus preference are more likely an effect of judging preference, not an effect of overt labeling. Labeling does not influence memory by shifting memory representations toward the category prototype. Rather, labeling objects at the basic level produces memory representations that are simply less robust than those produced by other kinds of study tasks.

  4. Looking at the label and beyond: the effects of calorie labels, health consciousness, and demographics on caloric intake in restaurants

    PubMed Central

    2013-01-01

    Background Recent legislation has required calorie labels on restaurant menus as a means of improving Americans’ health. Despite the growing research in this area, no consensus has been reached on the effectiveness of menu labels. This suggests the possibility of heterogeneity in responses to caloric labels across people with different attitudes and demographics. The purpose of this study was to explore the potential relationships between caloric intake and diners’ socio-economic characteristics and attitudes in a restaurant field experiment that systematically varied the caloric information printed on the menus. Methods We conducted a field experiment in a full service restaurant where patrons were randomly assigned to one of three menu treatments which varied the amount of caloric information printed on the menus (none, numeric, or symbolic calorie label). At the conclusion of their meals, diners were asked to complete a brief survey regarding their socio-economic characteristics, attitudes, and meal selections. Using regression analysis, we estimated the number of entrée and extra calories ordered by diners as a function of demographic and attitudinal variables. Additionally, irrespective of the menu treatment to which a subject was assigned, our study identified which types of people are likely to be low-, medium-, and high-calorie diners. Results Results showed that calorie labels have the greatest impact on those who are least health conscious. Additionally, using a symbolic calorie label can further reduce the caloric intake of even the most health conscious patrons. Finally, calorie labels were more likely to influence the selection of the main entrée as opposed to supplemental items such as drinks and desserts. Conclusions If numeric calorie labels are implemented (as currently proposed), they are most likely to influence consumers who are less health conscious – probably one of the key targets of this legislation. Unfortunately, numeric labels did

  5. The Effect of Labeling on Preschool Children's Performance in the Dimensional Change Card Sort Task

    ERIC Educational Resources Information Center

    Muller, Ulrich; Zelazo, Philip D.; Lurye, Leah E.; Liebermann, Dana P.

    2008-01-01

    Previous research suggests that experimenter-induced labeling of test cards improves preschoolers' performance on the Dimensional Change Card Sort Task (DCCS), a measure of flexible rule use. Three experiments attempted to further clarify how labeling aids performance on the DCCS. Experiment 1 examined the nature of the labeling effect but failed…

  6. Category Label Effects on Chinese Children's Inductive Inferences: Modulation by Perceptual Detail and Category Specificity

    ERIC Educational Resources Information Center

    Long, Changquan; Lu, Xiaoying; Zhang, Li; Li, Hong; Deak, Gedeon O.

    2012-01-01

    Inductive generalization of novel properties to same-category or similar-looking objects was studied in Chinese preschool children. The effects of category labels on generalizations were investigated by comparing basic-level labels, superordinate-level labels, and a control phrase applied to three kinds of stimulus materials: colored photographs…

  7. 21 CFR 201.63 - Pregnancy/breast-feeding warning.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., MD 20852. (e) The labeling of orally or rectally administered OTC aspirin and aspirin-containing drug... this section. The warning shall be as follows: “It is especially important not to use” (select...

  8. 21 CFR 201.63 - Pregnancy/breast-feeding warning.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., MD 20852. (e) The labeling of orally or rectally administered OTC aspirin and aspirin-containing drug... this section. The warning shall be as follows: “It is especially important not to use” (select...

  9. 21 CFR 201.63 - Pregnancy/breast-feeding warning.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., MD 20852. (e) The labeling of orally or rectally administered OTC aspirin and aspirin-containing drug... this section. The warning shall be as follows: “It is especially important not to use” (select...

  10. 21 CFR 201.63 - Pregnancy/breast-feeding warning.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., MD 20852. (e) The labeling of orally or rectally administered OTC aspirin and aspirin-containing drug... this section. The warning shall be as follows: “It is especially important not to use” (select...

  11. 21 CFR 201.63 - Pregnancy/breast-feeding warning.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., MD 20852. (e) The labeling of orally or rectally administered OTC aspirin and aspirin-containing drug... this section. The warning shall be as follows: “It is especially important not to use” (select...

  12. Wind gust warning verification

    NASA Astrophysics Data System (ADS)

    Primo, Cristina

    2016-07-01

    Operational meteorological centres around the world increasingly include warnings as one of their regular forecast products. Warnings are issued to warn the public about extreme weather situations that might occur leading to damages and losses. In forecasting these extreme events, meteorological centres help their potential users in preventing the damage or losses they might suffer. However, verifying these warnings requires specific methods. This is due not only to the fact that they happen rarely, but also because a new temporal dimension is added when defining a warning, namely the time window of the forecasted event. This paper analyses the issues that might appear when dealing with warning verification. It also proposes some new verification approaches that can be applied to wind warnings. These new techniques are later applied to a real life example, the verification of wind gust warnings at the German Meteorological Centre ("Deutscher Wetterdienst"). Finally, the results obtained from the latter are discussed.

  13. The effects of radioiodination and fluorescent labelling on albumin

    SciTech Connect

    Crandall, R.E.; Janatova, J.; Andrade, J.D.

    1981-01-01

    The preparation and characterization of fluorescamine -, fluorescein isothiocyanate (FITC) -, and radioiodine-labelled bovine serum albumin is critically evaluated. Electrophoretic mobility and ion-exchange chromatography, together with measures of degree of conjugation and sulfhydryl content, are used to assess the changes due to conjugation. Fluorescamine labelling results in drastic changes in chromatographic behavior and electrophoretic mobility. FITC labelling also results in significant changes in chromatographic and electrophoretic properties. Radioiodination leads to minor changes in chromatographic properties and oxydation of sulfhydryl groups, with little or no change in electrophoretic properties. All three labels have some degree of lability and show increased levels of free label with time, even after extensive initial purification. It is concluded that the two fluorescent labels and possibly the radioiodine labelling method used here are unsuitable for certain studies of BSA, such as its adsorption at solid-liquid interfaces.

  14. Emolabeling effectively reduces the influence of ambiguous labeling on food packages among grocery store shoppers.

    PubMed

    Privitera, Gregory J; Brown, Caitlin J; Gillespie, James J

    2014-12-16

    Despite increased regulations and policy enforcement for nutrition labeling, ambiguous labels on food items can still have deleterious effects on consumer perceptions of health. The present study used a counterbalanced within-subjects design to test if emolabeling - the use of emoticons to convey health information (happy = healthy; sad = not healthy) - will reduce the effects of ambiguous labels on consumer perceptions of the healthfulness of a food item. 85 grocery store shoppers were shown nutrition labels for a low calorie (LC) and a high calorie (HC) food with/without emolabels, and with an ambiguous label that either implied the food was healthy or unhealthy. Results showed that emolabels reduced the effectiveness of ambiguous labels: consumers rated the LC food as healthier and the HC food as less healthy when emolabels were added. The results suggest that, if implemented, this image-based emolabeling system could possibly be an effective buffer against the use of ambiguous labeling by food manufacturers.

  15. Emolabeling effectively reduces the influence of ambiguous labeling on food packages among grocery store shoppers.

    PubMed

    Privitera, Gregory J; Brown, Caitlin J; Gillespie, James J

    2015-01-01

    Despite increased regulations and policy enforcement for nutrition labeling, ambiguous labels on food items can still have deleterious effects on consumer perceptions of health. The present study used a counterbalanced within-subjects design to test if emolabeling - the use of emoticons to convey health information (happy = healthy; sad = not healthy) - will reduce the effects of ambiguous labels on consumer perceptions of the healthfulness of a food item. 85 grocery store shoppers were shown nutrition labels for a low calorie (LC) and a high calorie (HC) food with/without emolabels, and with an ambiguous label that either implied the food was healthy or unhealthy. Results showed that emolabels reduced the effectiveness of ambiguous labels: consumers rated the LC food as healthier and the HC food as less healthy when emolabels were added. The results suggest that, if implemented, this image-based emolabeling system could possibly be an effective buffer against the use of ambiguous labeling by food manufacturers. PMID:25946913

  16. The "SABEIS" Project: Warning systems based on earthquake and tsunamis-induced ionospheric effects.

    NASA Astrophysics Data System (ADS)

    Rodriguez-Bouza, Marta; Sánchez-Dulcet, Francisco; Herraiz, Miguel; Rodríguez-Caderot, Gracia; Altadill, David; Blanch, Estefania; Santoyo, Miguel Angel

    2016-04-01

    The study of a possible lithosphere-atmosphere-ionosphere coupling (LAI) is mainly focused on the analysis and comprehension of atmospheric and ionospheric anomalies caused by extreme lithospheric events. In this context, earthquakes are considered as possible sources of atmosphere-ionosphere anomalies. The goal of the two-year long project SABEIS (Sistemas de Alerta Basados en Efectos de terremotos y tsunamis en la IonoSfera) granted by the Spanish Ministry of Economy and Competitiveness, is to analyze the disturbances caused by earthquakes and tsunamis and their possible contribution to warning systems. These topics are receiving increased attention in the scientific community and their correct understanding can meaningfully contribute to the protection of people and economic assets in areas subject to seismic threat. The project is based on the analysis of Total Electron Content (TEC) obtained from signals of Global Navigation Satellite Systems (GNSS) and anomalies of the ionospheric F2 layer observed in ionograms. This methodology was partially applied in a previous study of the Mw6.1 earthquake in Greece occurred on January 26, 2014. In that case two TEC disturbances were detected the days prior the earthquake. The first one, four days before, was registered by the majority of the stations analyzed over Europe and after studying its temporal variation, was considered unrelated to the earthquake. The second one occurred the day before the earthquake. This anomaly appeared only at stations close to the epicenter and their temporal proximity to the earthquake point to a possible connection with the earthquake preparation process. In the SABEIS project possible anomalies caused by earthquakes in Mexico and Peru with magnitude ranging from 5.5 to 8.2, will be studied. If the results confirm the influence of seismic events on the ionosphere, the possibility of incorporating this type of analysis in a seismic alert network for the Gulf of Cadiz (southern Iberian

  17. Effects of the label "mentally retarded" on causal explanations for success and failure outcomes.

    PubMed

    Severance, L J; Gasstrom, L L

    1977-05-01

    Previous research has been inconclusive in demonstrating the effects of the label "mentally retarded" on the reactions and evaluations of others toward the labeled person. The present study derived predictions from attribution theory regarding the effects of the label on the perceptions of observers. Specifically, we hypothesized that the presence of the label would reduce the likelihood that observers would credit successful task outcomes to the labeled person's ability but enhance the likelihood that observers would credit unsuccessful task outcomes to the labeled person's ability. Such effects were not anticipated in the absence of the label. A factorial design varying Labels (mentally retarded us. no label), Task Outcomes (success v. failure), and Sex of Target Person was employed. Dependent variables measured observers' assessments of the causes of the target person's outcomes. The results strongly confirmed the hypothesis by showing that ability, effort, and task difficulty are all perceived differently for labeled than for nonlabeled target persons. The results were discussed in terms of implications for future research and proper use of the label "mentally retarded."

  18. Effects of labeling on preschoolers' explicit false belief performance: outcomes of cognitive flexibility or inhibitory control?

    PubMed

    Low, Jason; Simpson, Samantha

    2012-01-01

    Executive function mechanisms underpinning language-related effects on theory of mind understanding were examined in a sample of 165 preschoolers. Verbal labels were manipulated to identify relevant perspectives on an explicit false belief task. In Experiment 1 with 4-year-olds (N = 74), false belief reasoning was superior in the fully and protagonist-perspective labeled conditions compared to the child-perspective and nondescript labeling conditions. In Experiment 2 with 3-year-olds (N = 53), labeling the nondominant belief only biased attentional inertia. In Experiment 3 testing generalization in 4-year-olds (N = 38), labeling manipulations translated to improved performance on a second label-free explicit false belief task. These outcomes fit a cognitive flexibility account whereby age changes in the effects of labeling turn on formulating sophisticated conceptual representations.

  19. Reducing online identity disclosure using warnings.

    PubMed

    Carpenter, Sandra; Zhu, Feng; Kolimi, Swapna

    2014-09-01

    In an experimental design, we tested whether written warnings can reduce the amount of identity information exposure online. A psychological attack on information privacy that has been shown to be effective in previous research was launched. This attack took advantage of the fact that people respond to certain types of requests in a relatively automatic, or mindless, fashion. The experiment manipulated the word that was used in the alert header: "warning", "caution", or "hazard". All warnings proved to be effective in reducing disclosure, but "hazard" proved to be most effective. Also warnings were more effective in reducing disclosure of driver's license numbers than email addresses. The discussion (a) provides tentative conclusions why these patterns were obtained, (b) suggests how to design warnings in cyber-environments, and (c) addresses future possibilities for research on this topic. PMID:24161300

  20. Reducing online identity disclosure using warnings.

    PubMed

    Carpenter, Sandra; Zhu, Feng; Kolimi, Swapna

    2014-09-01

    In an experimental design, we tested whether written warnings can reduce the amount of identity information exposure online. A psychological attack on information privacy that has been shown to be effective in previous research was launched. This attack took advantage of the fact that people respond to certain types of requests in a relatively automatic, or mindless, fashion. The experiment manipulated the word that was used in the alert header: "warning", "caution", or "hazard". All warnings proved to be effective in reducing disclosure, but "hazard" proved to be most effective. Also warnings were more effective in reducing disclosure of driver's license numbers than email addresses. The discussion (a) provides tentative conclusions why these patterns were obtained, (b) suggests how to design warnings in cyber-environments, and (c) addresses future possibilities for research on this topic.

  1. Testing warning messages on smokers’ cigarette packages: A standardized protocol

    PubMed Central

    Brewer, Noel T.; Hall, Marissa G.; Lee, Joseph G. L.; Peebles, Kathryn; Noar, Seth M.; Ribisl, Kurt M.

    2015-01-01

    Purpose Lab experiments on cigarette warnings typically use a brief one-time exposure that is not paired with the cigarette packs smokers use every day, leaving open the question of how repeated warning exposure over several weeks may affect smokers. This proof of principle study sought to develop a new protocol for testing cigarette warnings that better reflects real-world exposure by presenting them on cigarette smokers’ own packs. Methods We tested a cigarette pack labeling protocol with 76 US smokers ages 18 and older. We applied graphic warnings to the front and back of smokers’ cigarette packs. Results Most smokers reported that at least 75% of the packs of cigarettes they smoked during the study had our warnings. Nearly all said they would participate in the study again. Using cigarette packs with the study warnings increased quit intentions (p<.05). Conclusion Our findings suggest a feasible pack labeling protocol with six steps: (1) schedule appointments at brief intervals; (2) determine typical cigarette consumption; (3) ask smokers to bring a supply of cigarette packs to study appointments; (4) apply labels to smokers’ cigarette packs; (5) provide participation incentives at the end of appointments; and (6) refer smokers to cessation services at end of the study. When used in randomized controlled trials in settings with real-world message exposure over time, this protocol may help identify the true impact of warnings and thus better inform tobacco product labeling policy. PMID:25564282

  2. Long-Term Effects of Labeling a Rape Experience

    ERIC Educational Resources Information Center

    McMullin, Darcy; White, Jacquelyn W.

    2006-01-01

    Research has found that approximately half of women who report an experience that meets the legal definition of rape do not label it rape. It has been assumed that labeling the experience as rape is necessary and beneficial for recovery; however, conflicting findings have been reported. In the present study, a longitudinal design was utilized to…

  3. 24 CFR 200.1505 - Warning letter.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Multifamily Accelerated Processing (MAP): MAP... letter, which specifies problems or violations identified by HUD, to a MAP lender. (b) Effect of warning letter. The warning letter: (1) Does not suspend a lender's MAP privileges; (2) May impose a higher...

  4. Consumer involvement: effects on information processing from over-the-counter medication labels.

    PubMed

    Sansgiry, S S; Cady, P S; Sansgiry, S

    2001-01-01

    The objective of this study was to evaluate the effects of consumer involvement on information processing from over-the-counter (OTC) medication labels. A sample of 256 students evaluated simulated OTC product labels for two product categories (headache and cold) in random order. Each participant evaluated labels after reading a scenario to simulate high and low involvement respectively. A questionnaire was used to collect data on variables such as label comprehension, attitude-towards-product label, product evaluation, and purchase intention. The results indicate that when consumers are involved in their purchase of OTC medications they are significantly more likely to understand information from the label and evaluate it accordingly. However, involvement does not affect attitude-towards-product label nor does it enhance purchase intention. PMID:11727293

  5. [How would plain packaging and pictorial warning impact on smoking reduction, cessation and initiation?].

    PubMed

    Mannocci, Alice; Colamesta, Vittoria; Mipatrini, Daniele; Boccia, Antonio; Terzano, Claudio; La Torre, Giuseppe

    2013-01-01

    The European Commission has proposed a review of the directive on tobacco products on labeling and packaging of tobacco products by introducing warning text with pictorial warning that occupies 75% of the cigarette packages. The aim of the survey was to assess the impact of plain packaging and pictorial warning in smoking reduction, cessation and initiation among a sample of adult. The cross-sectional study was conducted in Rome between September and November 2012. The questionnaires administered were 227, with a response rate of 82.4%. 35.8% (No. 67) of the respondents considered the image of the gangrene the most effective in communicating smoking-related damages, followed by the image on lung cancer (No. 60; 32.1%). Distinguishing between smokers and non-smokers (both former and never smokers), the picture on lung cancer was the most effective for smokers (No. 22; 38.6%); if cigarette packages have pictorial warnings like the ones shown, more than half (No. 33; 57.9%) of smokers would change brand; 66.7% (No. 38) of them would feel uncomfortable in showing the package. Comparing the 3 packagings, classic packaging, plain packaging with textual warning, and plain packaging with both textual and pictorial warning, the majority of people declared that the third is the most effective in preventing smoking initiation (No. 169; 90.9%), in motivating to quit (No. 158; 84.9%), and in changing smoking habits (No. 149; 80.5%). The survey, although its small sample size and being not representative of all strata of Italian population, shows that the plain packaging with pictorial warning is the most convincing in the three outcomes considered. PMID:24548838

  6. 'Retouch free': The effect of labelling media images as not digitally altered on women's body dissatisfaction.

    PubMed

    Tiggemann, Marika; Slater, Amy; Smyth, Veronica

    2014-01-01

    This study aimed to investigate the effect of 'retouch free' labels on thin ideal fashion images on women's body dissatisfaction. This represents an experimental analogue to current practice by some fashion magazines. Participants were 224 female undergraduates who viewed a set of fashion shoots with either no label, or a label indicating that the image had not been digitally altered. Results indicated that, although body dissatisfaction increased after exposure to the thin ideal images, there was no significant effect of label type on mood or body dissatisfaction. It was concluded that labelling images as digitally unaltered appears neither helpful nor harmful in terms of body dissatisfaction. Nevertheless, more extensive research is required to guide the most effective use of labels.

  7. Multitasking in academia: Effective combinations of research, education and public outreach illustrated by a volcanic ash warning system

    NASA Astrophysics Data System (ADS)

    Bye, B. L.; Plag, H.

    2011-12-01

    Science permeates our society. Its role and its perceived importance evolves with time. Scientists today are highly specialized, yet society demands they master a variety of skills requiring not only a number of different competencies but also a broad mindset. Scientists are subjected to a meritocracy in terms of having to produce scientific papers. Peer-reviewed scientific publications used to be sufficient to meet the various laws and regulations with respect to dissemination of scientific results. This has dramatically changed; both expressed directly through public voices (such as in the climate change discourses), but also by politicians and policy makers. In some countries research funding now comes with specific requirements concerning public outreach that go way beyond peer-reviewed publications and presentation at scientific conferences. Science policies encourage multidisciplinary cooperation and scientific questions themselves often cannot be answered without knowledge and information from several scientific areas. Scientists increasingly need to communicate knowledge and results in more general terms as well as educating future generations. A huge challenge lies in developing the knowledge, human capacity and mindset that will allow an individual academician to contribute to education, communicate across scientific fields and sectors in multidisciplinary cross sectoral cooperations and also reach out to the general public while succeeding within the scientific meritocracy. We demonstrate how research, education and communication within and outside academia can effectively be combined through a presentation of the International Airways Volcano Watch that encompasses an operational volcanic ash warning system for the aviation industry. This presentation will show the role of science throughout the information flow, from basic science to the pilots' decision-making. Furthermore, it will illustrate how one can connect specific scientific topics to societal

  8. Effects of safety warnings on prescription rates of cough and cold medicines in children below 2 years of age

    PubMed Central

    Sen, E Fatma; Verhamme, Katia M C; Felisi, Mariagrazia; 't Jong, Geert W; Giaquinto, Carlo; Picelli, Gino; Ceci, Adriana; Sturkenboom, Miriam C J M

    2011-01-01

    AIM The aim of the study was to assess the influence of national and international warnings on the prescription rates of cough and cold medicines (CCMs) in the youngest children (<2 years) in the Netherlands and Italy. METHODS Analysis of outpatient electronic medical records of children <2 years in Italy and the Netherlands was carried out. Age and country specific prescription prevalence rates were calculated for the period 2005–08. Comparisons of prescription rates in 2005 (pre) and 2008 (post) warnings were done by means of a chi-square test. RESULTS The cohort consisted of 99 176 children <2 years of age. After international warnings, overall prescription rates for CCMs decreased slightly from 83 to 77/1000 person years (P = 0.05) in Italy and increased in the Netherlands from 74 to 92/1000 children per year. Despite the international warnings, prescription rates for nasal sympathomimetics and opium alkaloids increased in the Netherlands (P < 0.01). In Italy a significant decrease in the prescription rates of opium alkaloids and other cough suppressants (P < 0.01) was observed, and also a significant reduction in use of combinations of nasal sympathomimetics. CONCLUSION Despite the international safety warnings and negative benefit-risk profiles, prescription rates of cough and cold medicines remain substantial and were hardly affected by the warnings, especially in the Netherlands where no warning was issued. The hazards of use of these medicines in young children should be explicitly stipulated by the European Medicines Agency and all national agencies, in order to increase awareness amongst physicians and caretakers and reduce heterogeneity across the EU. PMID:21564162

  9. 77 FR 72868 - Compliance Guidance for Small Business Entities on Labeling and Effectiveness Testing; Sunscreen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... (76 FR 35620) regarding labeling and testing requirements for OTC sunscreen drug products. Under the... and Effectiveness Testing; Sunscreen Drug Products for Over-the-Counter Human Use; Notice of... ``Labeling and Effectiveness Testing: Sunscreen Drug Products for Over-the-Counter Human Use; Small...

  10. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    PubMed

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation.

  11. Negative Treatment Effects: Is It Time for a Black Box Warning?

    ERIC Educational Resources Information Center

    Boisvert, Charles M.

    2010-01-01

    Comments on Negative effects from psychological treatments: A perspective by David Barlow. The author addresses negative treatment effects in the psychotherapy field by stating that Barlow provided a historical perspective of clinical psychology's long-standing interest in studying the positive effects of psychotherapy, and he indicated that…

  12. Radioactively contaminated areas: Bioindicator species and biomarkers of effect in an early warning scheme for a preliminary risk assessment.

    PubMed

    Lourenço, Joana; Mendo, Sónia; Pereira, Ruth

    2016-11-01

    Concerns about the impacts on public health and on the natural environment have been raised regarding the full range of operational activities related to uranium mining and the rest of the nuclear fuel cycle (including nuclear accidents), nuclear tests and depleted uranium from military ammunitions. However, the environmental impacts of such activities, as well as their ecotoxicological/toxicological profile, are still poorly studied. Herein, it is discussed if organisms can be used as bioindicators of human health effects, posed by lifetime exposure to radioactively contaminated areas. To do so, information was gathered from several studies performed on vertebrates, invertebrate species and humans, living in these contaminated areas. The retrieved information was compared, to determine which are the most used bioindicators and biomarkers and also the similarities between human and non-human biota responses. The data evaluated are used to support the proposal for an early warning scheme, based on bioindicator species and on the most sensitive and commonly shared biomarkers, to perform a screening evaluation of radioactively contaminated sites. This scheme could be used to support decision-making for a deeper evaluation of risks to human health, making it possible to screen a large number of areas, without disturbing and alarming local populations.

  13. Radioactively contaminated areas: Bioindicator species and biomarkers of effect in an early warning scheme for a preliminary risk assessment.

    PubMed

    Lourenço, Joana; Mendo, Sónia; Pereira, Ruth

    2016-11-01

    Concerns about the impacts on public health and on the natural environment have been raised regarding the full range of operational activities related to uranium mining and the rest of the nuclear fuel cycle (including nuclear accidents), nuclear tests and depleted uranium from military ammunitions. However, the environmental impacts of such activities, as well as their ecotoxicological/toxicological profile, are still poorly studied. Herein, it is discussed if organisms can be used as bioindicators of human health effects, posed by lifetime exposure to radioactively contaminated areas. To do so, information was gathered from several studies performed on vertebrates, invertebrate species and humans, living in these contaminated areas. The retrieved information was compared, to determine which are the most used bioindicators and biomarkers and also the similarities between human and non-human biota responses. The data evaluated are used to support the proposal for an early warning scheme, based on bioindicator species and on the most sensitive and commonly shared biomarkers, to perform a screening evaluation of radioactively contaminated sites. This scheme could be used to support decision-making for a deeper evaluation of risks to human health, making it possible to screen a large number of areas, without disturbing and alarming local populations. PMID:27343869

  14. Mandatory cancer risk warnings on alcoholic beverages: what are the ethical issues?

    PubMed

    Louise, Jennie; Eliott, Jaklin; Olver, Ian; Braunack-Mayer, Annette

    2015-01-01

    The link between alcohol consumption and cancer is well established, but public awareness of the risk remains low. Mandated warning labels have been suggested as a way of ensuring "informed choice" about alcohol consumption. In this article we explore various ethical issues that may arise in connection with cancer warning labels on alcoholic beverages; in particular we highlight the potentially questionable autonomy of alcohol consumption decisions (either with or without labels) and consider the implications if the autonomy of drinking behavior is substantially compromised. Our discussion demonstrates the need for the various ethical issues to be considered and addressed in any decision to mandate cancer warning labels.

  15. Timely Warning Update

    ERIC Educational Resources Information Center

    Stafford, Dolores

    2011-01-01

    A complaint received by the Department of Education alleged that Virginia Tech violated the "timely warning" requirements of the Clery Act on April 16, 2007, by not issuing specific campus-wide alerts once senior officials knew of the immediate threat to health and safety. The complaint also alleged that the University's timely warning policy, as…

  16. Airlock caution and warning system

    NASA Technical Reports Server (NTRS)

    Mayfield, W. J.; Cork, L. Z.; Malchow, R. G.; Hornback, G. L.

    1972-01-01

    Caution and warning system, used to monitor performance and warn of hazards or out-of-limit conditions on space vehicles, may have application to aircraft and railway transit systems. System consists of caution and warning subsystem and emergency subsystem.

  17. Effective isotope labeling of proteins in a mammalian expression system.

    PubMed

    Sastry, Mallika; Bewley, Carole A; Kwong, Peter D

    2015-01-01

    Isotope labeling of biologically interesting proteins is a prerequisite for structural and dynamics studies by NMR spectroscopy. Many of these proteins require mammalian cofactors, chaperons, or posttranslational modifications such as myristoylation, glypiation, disulfide bond formation, or N- or O-linked glycosylation; and mammalian cells have the necessary machinery to produce them in their functional forms. Here, we describe recent advances in mammalian expression, including an efficient adenoviral vector-based system, for the production of isotopically labeled proteins. This system enables expression of mammalian proteins and their complexes, including proteins that require posttranslational modifications. We describe a roadmap to produce isotopically labeled (15)N and (13)C posttranslationally modified proteins, such as the outer domain of HIV-1 gp120, which has four disulfide bonds and 15 potential sites of N-linked glycosylation. These methods should allow NMR spectroscopic analysis of the structure and function of posttranslationally modified and secreted, cytoplasmic, or membrane-bound proteins.

  18. Emphasized warning reduces salt intake: a randomized controlled trial.

    PubMed

    Pinjuh Markota, Nina; Rumboldt, Mirjana; Rumboldt, Zvonko

    2015-03-01

    Excessive salt intake is a major cardiovascular risk factor. At variance to the developed countries, the main source of sodium in transitional and developing countries is salt added while cooking and/or at the table. The objective of this trial was to examine the impact of warning labels placed on home salt containers on daily salt intake.A sample of treated hypertensives (n = 150) was randomized in two subgroups, one receiving just a leaflet about the harmful effects of excessive salt intake (control; n = 74), and the other one receiving in addition warning stickers for household salt containers (intervention; n = 76). Arterial blood pressure (BP) and 24-hour urinary sodium excretion (Na24) were measured in all the subjects at the start of the trial, and 1 month and 2 months later. The average starting Na24 was 207 ± 71 mmol in the control group and 211 ± 85 mmol in the intervention group (P = .745). One month and 2 months later, a significant decrease was observed in the intervention group (to 183 ± 63 mmol and 176 ± 55 mmol; P < .0001), as opposed to the control group (203 ± 60 mmol and 200 ± 58 mmol; P = .1466). Initial BP was 143.7/84.1 mm Hg in the control, and 142.9/84.7 mm Hg in the intervention group (P = .667). One month and 2 months later, a significant drop in BP, by 5.3/2.9 mm Hg, was observed in the intervention group as opposed to the control group (0.4/0.9 mm Hg). Decrease in Na24 positively correlated to BP lowering (r(2) = 0.5989; P < .0001). A significant reduction in 24Na and BP is achieved with warning labels on harmful effects of excessive salt intake. Decreasing daily salt input by 35 mmol may result in an extra BP lowering by some 5-6/2-3 mm Hg.

  19. Effect of preparation procedures on intensity of radioautographic labeling is studied

    NASA Technical Reports Server (NTRS)

    Baserga, R.; Kisieleski, W. E.

    1967-01-01

    Effects of tissue preparation and extractive procedures on the intensity of radioautographic labeling are presented in terms of mean grain count per cell in cells labeled with tritiated precursors of proteins or nucleic acids. This information would be of interest to medical researchers and cytologists.

  20. Effects of Labeling and Teacher Certification Type on Recall and Conflict Resolution

    ERIC Educational Resources Information Center

    Ayers, Jane M.; Krueger, Lacy E.; Jones, Beth A.

    2015-01-01

    Understanding how labels and prior training affect teachers of students with a disability is a step toward creating effective educational environments. Two goals of the present study were to examine how teacher training (special education vs. general education training) and labeling of students (either as having attention deficit hyperactivity…

  1. The Unintended Effects of Interactive Objects and Labels in the Science Museum

    ERIC Educational Resources Information Center

    Atkins, Leslie J.; Velez, Lisanne; Goudy, David; Dunbar, Kevin N.

    2009-01-01

    What effects do different setups of museum exhibits have on visitors' conversations and interactions? The study reported here is an investigation of the role that labels and associated materials play in visitors' conversations and interactions at a heat camera exhibit. After we introduced a label to help visitors explore the insulating properties…

  2. Application of a Tsunami Warning Message Metric to refine NOAA NWS Tsunami Warning Messages

    NASA Astrophysics Data System (ADS)

    Gregg, C. E.; Johnston, D.; Sorensen, J.; Whitmore, P.

    2013-12-01

    In 2010, the U.S. National Weather Service (NWS) funded a three year project to integrate social science into their Tsunami Program. One of three primary requirements of the grant was to make improvements to tsunami warning messages of the NWS' two Tsunami Warning Centers- the West Coast/Alaska Tsunami Warning Center (WCATWC) in Palmer, Alaska and the Pacific Tsunami Warning Center (PTWC) in Ewa Beach, Hawaii. We conducted focus group meetings with a purposive sample of local, state and Federal stakeholders and emergency managers in six states (AK, WA, OR, CA, HI and NC) and two US Territories (US Virgin Islands and American Samoa) to qualitatively asses information needs in tsunami warning messages using WCATWC tsunami messages for the March 2011 Tohoku earthquake and tsunami event. We also reviewed research literature on behavioral response to warnings to develop a tsunami warning message metric that could be used to guide revisions to tsunami warning messages of both warning centers. The message metric is divided into categories of Message Content, Style, Order and Formatting and Receiver Characteristics. A message is evaluated by cross-referencing the message with the operational definitions of metric factors. Findings are then used to guide revisions of the message until the characteristics of each factor are met. Using findings from this project and findings from a parallel NWS Warning Tiger Team study led by T. Nicolini, the WCATWC implemented the first of two phases of revisions to their warning messages in November 2012. A second phase of additional changes, which will fully implement the redesign of messages based on the metric, is in progress. The resulting messages will reflect current state-of-the-art knowledge on warning message effectiveness. Here we present the message metric; evidence-based rational for message factors; and examples of previous, existing and proposed messages.

  3. THE EFFECTS ON DRIVING SPEED OF A HEAD-UP DISPLAY OF ROAD WARNINGS (1).

    PubMed

    Huang, Cheng-Hung; Chao, Chun-Wen

    2015-10-01

    This study investigated the superimposition of the projected markings on the road with head-up display, as well as their effects on the driver's speed. Two experiments were conducted. In Exp. 1, driving operations were simulated with a desktop computer to assess 18 deceleration markings (from the factors position, shape, and color) and determined the factors and levels influencing driving speeds. Based on the results of Exp. 1, six deceleration markings (from the factors shape and color) were selected in the driving simulator for conducting Exp. 2. The results of Exp. 1 showed that markings at the sides were better than the markings in the center. In Exp. 2, there was no significant difference between the effects of the arrangement of markings and the change of shape and color on driving stability. Yellow and white colors had no significant effect on speed; however, bar markings were better than zigzag markings. The results indicated that the projection of markings on a head-up display was helpful for indicating necessary deceleration. PMID:26474437

  4. Effective and site-specific phosphoramidation reaction for universally labeling nucleic acids.

    PubMed

    Su, Yu-Chih; Chen, Hsing-Yin; Ko, Ni Chien; Hwang, Chi-Ching; Wu, Min Hui; Wang, Li-Fang; Wang, Yun-Ming; Chang, Sheng-Nan; Wang, Eng-Chi; Wang, Tzu-Pin

    2014-03-15

    Here we report efficient and selective postsynthesis labeling strategies, based on an advanced phosphoramidation reaction, for nucleic acids of either synthetic or enzyme-catalyzed origin. The reactions provided phosphorimidazolide intermediates of DNA or RNA which, whether reacted in one pot (one-step) or purified (two-step), were directly or indirectly phosphoramidated with label molecules. The acquired fluorophore-labeled nucleic acids, prepared from the phosphoramidation reactions, demonstrated labeling efficacy by their F/N ratio values (number of fluorophores per molecule of nucleic acid) of 0.02-1.2 which are comparable or better than conventional postsynthesis fluorescent labeling methods for DNA and RNA. Yet, PCR and UV melting studies of the one-step phosphoramidation-prepared FITC-labeled DNA indicated that the reaction might facilitate nonspecific hybridization in nucleic acids. Intrinsic hybridization specificity of nucleic acids was, however, conserved in the two-step phosphoramidation reaction. The reaction of site-specific labeling nucleic acids at the 5'-end was supported by fluorescence quenching and UV melting studies of fluorophore-labeled DNA. The two-step phosphoramidation-based, effective, and site-specific labeling method has the potential to expedite critical research including visualization, quantification, structural determination, localization, and distribution of nucleic acids in vivo and in vitro.

  5. Maternal Labeling of Gifted Children: Effects on the Sibling Relationship.

    ERIC Educational Resources Information Center

    Tuttle, Diane Hoekstra; Cornell, Dewey G.

    1993-01-01

    This study examined the impact of maternal labeling of children as gifted on the sibling relationship in 144 pairs of firstborn and secondborn siblings classified as both gifted, firstborn gifted, secondborn gifted, or neither gifted. Five aspects of the sibling relationship were examined: warmth/closeness, status/power, conflict, maternal…

  6. Effects of Labeling and Group Category of Evaluators on Evaluations of Aggression

    PubMed Central

    Teraguchi, Tsukasa; Kugihara, Naoki

    2015-01-01

    This study investigated whether the effect of labeling on people’s evaluation of aggression varies according to the group category of the evaluators (i.e., whether they are ingroup members or third parties). Two labeling strategies—the negative labeling of victims (NL strategy) and the positive labeling of aggressors (PL strategy)–were adopted. We conducted an experiment using the hot sauce paradigm, as a way to assess aggressive intent that includes behavioral measures of evaluations. The results suggested that the NL strategy causes ingroup members to evaluate aggression in a more positive light, while the PL strategy has the same effect but on third parties instead. Thus, labeling strategies may increase the severity of aggressors’ reaction and could also be a factor that can escalate a war or conflict. PMID:26646836

  7. Atmospheric effects on voice command intelligibility from acoustic hail and warning devices.

    PubMed

    Bostron, Jason H; Brungart, Timothy A; Barnard, Andrew R; McDevitt, Timothy E

    2011-04-01

    Voice command sound pressure levels (SPLs) were recorded at distances up to 1500 m. Received SPLs were related to the meteorological condition during sound propagation and compared with the outdoor sound propagation standard ISO 9613-2. Intelligibility of received signals was calculated using ANSI S3.5. Intelligibility results for the present voice command indicate that meteorological condition imposes little to no effect on intelligibility when the signal-to-noise ratio (SNR) is low (<-9 dB) or high (>0 dB). In these two cases the signal is firmly unintelligible or intelligible, respectively. However, at moderate SNRs, variations in received SPL can cause a fully intelligible voice command to become unintelligible, depending on the meteorological condition along the sound propagation path. These changes in voice command intelligibility often occur on time scales as short as minutes during upward refracting conditions, typically found above ground during the day or upwind of a sound source. Reliably predicting the intelligibility of a voice command in a moderate SNR environment can be challenging due to the inherent variability imposed by sound propagation through the atmosphere.

  8. The Effects of Nutrition Knowledge on Food Label Use: A Review of the Literature

    PubMed Central

    Cassady, Diana L.

    2015-01-01

    Nutrition information on food labels is an important source of nutrition information but is typically underutilized by consumers. This review examined whether consumer nutrition knowledge is important for communication of nutrition information through labels on packaged foods. A cognitive processing model posits that consumers with prior knowledge are more likely to use label information effectively, that is, focus on salient information, understand information, and make healthful decisions based on this information. Consistent with this model, the review found that nutrition knowledge provides support for food label use. However, nutrition knowledge measures varied widely in terms of the dimensions they included and the extensiveness of the assessment. Relatively few studies investigated knowledge effects on the use of ingredient lists and claims, compared to nutrition facts labels. We also found an overreliance on convenience samples relying on younger adults, limiting our understanding of how knowledge supports food label use in later life. Future research should 1) investigate which dimensions, or forms, of nutrition knowledge are most critical to food label use and dietary decision making and 2) determine whether increases in nutrition knowledge can promote great use of nutrition information on food labels. PMID:26025086

  9. The effects of nutrition knowledge on food label use. A review of the literature.

    PubMed

    Miller, Lisa M Soederberg; Cassady, Diana L

    2015-09-01

    Nutrition information on food labels is an important source of nutrition information but is typically underutilized by consumers. This review examined whether consumer nutrition knowledge is important for communication of nutrition information through labels on packaged foods. A cognitive processing model posits that consumers with prior knowledge are more likely to use label information effectively, that is, focus on salient information, understand information, and make healthful decisions based on this information. Consistent with this model, the review found that nutrition knowledge provides support for food label use. However, nutrition knowledge measures varied widely in terms of the dimensions they included and the extensiveness of the assessment. Relatively few studies investigated knowledge effects on the use of ingredient lists and claims, compared to nutrition facts labels. We also found an overreliance on convenience samples relying on younger adults, limiting our understanding of how knowledge supports food label use in later life. Future research should 1) investigate which dimensions, or forms, of nutrition knowledge are most critical to food label use and dietary decision making and 2) determine whether increases in nutrition knowledge can promote great use of nutrition information on food labels. PMID:26025086

  10. The effects of nutrition knowledge on food label use. A review of the literature.

    PubMed

    Miller, Lisa M Soederberg; Cassady, Diana L

    2015-09-01

    Nutrition information on food labels is an important source of nutrition information but is typically underutilized by consumers. This review examined whether consumer nutrition knowledge is important for communication of nutrition information through labels on packaged foods. A cognitive processing model posits that consumers with prior knowledge are more likely to use label information effectively, that is, focus on salient information, understand information, and make healthful decisions based on this information. Consistent with this model, the review found that nutrition knowledge provides support for food label use. However, nutrition knowledge measures varied widely in terms of the dimensions they included and the extensiveness of the assessment. Relatively few studies investigated knowledge effects on the use of ingredient lists and claims, compared to nutrition facts labels. We also found an overreliance on convenience samples relying on younger adults, limiting our understanding of how knowledge supports food label use in later life. Future research should 1) investigate which dimensions, or forms, of nutrition knowledge are most critical to food label use and dietary decision making and 2) determine whether increases in nutrition knowledge can promote great use of nutrition information on food labels.

  11. Methods for nanoparticle labeling of ricin and effect on toxicity

    NASA Astrophysics Data System (ADS)

    Wark, Alastair W.; Yu, Jun; Lindsay, Christopher D.; Nativo, Paola; Graham, Duncan

    2009-09-01

    The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular, ricin is considered a significant bioterrorism risk due to its high toxicity combined with its ready availability as a byproduct in castor oil production. Therefore, the development of optical techniques capable of rapid on-site toxin detection with high molecular specificity and sensitivity continues to be of significant importance. Furthermore, understanding of the ricin cell entry and intracellular pathways remains poor due to a lack of suitable bioanalytical techniques. Initial work aimed at simultaneously tackling both these issues is described where different approaches for the nanoparticle labeling of ricin are investigated along with changes in ricin toxicity associated with the labeling process.

  12. Effect of acetaminophen on the leukocyte-labeling efficiency of indium oxine In 111

    SciTech Connect

    Augustine, S.C.; Schmelter, R.F.; Nelson, K.L.; Petersen, R.J.; Qualfe, M.A.

    1983-11-01

    The effect of acetaminophen on the labeling efficiency of leukocytes with indium oxine In 111 was studied. A blood sample was obtained from eight healthy men before and after they received acetaminophen 650 mg every four hours for 24 hours. After dividing the plasma from each sample into three portions, leukocytes were separated and labeled with indium oxine In 111. In an in vitro study, 200 ml of blood was obtained from one of the men, and the plasma was separated into four portions. Acetaminophen in 95% ethanol was added to three of the plasma fractions to produce acetaminophen concentrations of 4, 20, and 100 micrograms/ml; ethanol was added to the fourth fraction as a control. Each plasma fraction was then subdivided into three aliquots, and leukocytes were labeled as in the in vivo study. Mean leukocyte labeling efficiencies in both studies were calculated from the ratios of leukocyte radioactivity to initial radioactivity in the samples, expressed as percentages. Leukocyte labeling efficiencies before acetaminophen administration ranged from 79 to 85%; after administration, labeling efficiencies ranged from 70 to 87%. No significant differences in mean labeling efficiency before and after acetaminophen administration were noted in any of the subjects. Leukocyte labeling efficiencies in all in vitro plasma fractions were reduced, ranging from 54 to 63%, but no significant differences in labeling efficiency between any of the plasma fractions were found. Using the labeling procedures in this study, exposure of leukocytes from healthy men to acetaminophen in vivo or in vitro does not affect labeling efficiency with indium oxine In 111.

  13. The effects of nutrition labeling on consumer food choice: a psychological experiment and computational model.

    PubMed

    Helfer, Peter; Shultz, Thomas R

    2014-12-01

    The widespread availability of calorie-dense food is believed to be a contributing cause of an epidemic of obesity and associated diseases throughout the world. One possible countermeasure is to empower consumers to make healthier food choices with useful nutrition labeling. An important part of this endeavor is to determine the usability of existing and proposed labeling schemes. Here, we report an experiment on how four different labeling schemes affect the speed and nutritional value of food choices. We then apply decision field theory, a leading computational model of human decision making, to simulate the experimental results. The psychology experiment shows that quantitative, single-attribute labeling schemes have greater usability than multiattribute and binary ones, and that they remain effective under moderate time pressure. The computational model simulates these psychological results and provides explanatory insights into them. This work shows how experimental psychology and computational modeling can contribute to the evaluation and improvement of nutrition-labeling schemes. PMID:24913496

  14. Low-SES children's eyewitness memory: the effects of verbal labels and vocabulary skills.

    PubMed

    Chae, Yoojin; Kulkofsky, Sarah; Debaran, Francisco; Wang, Qi; Hart, Sybil L

    2014-01-01

    This study examined the effects of the verbal labels procedure and vocabulary skills on low-socioeconomic status (SES) preschool children's eyewitness memory. Children (N = 176) aged 3-5 years witnessed a conflict event and were then questioned about it in either a standard or a verbal labels interview. Findings revealed that children with higher rather than lower vocabulary skills produced more complete and accurate memories. Children who were given the verbal labels interview recalled more information, which included both correct and incorrect details. Overall, the verbal labels procedure did not improve children's performance on direct questions, but children with low vocabulary skills answered direct questions more accurately if they were given the verbal labels interview than when they were not. Implications of the findings for memory performance of low-SES children are discussed.

  15. Believing is seeing: the effects of racial labels and implicit beliefs on face perception.

    PubMed

    Eberhardt, Jennifer L; Dasgupta, Nilanjana; Banaszynski, Tracy L

    2003-03-01

    Two studies tested whether racial category labels and lay beliefs about human traits have a combined effect on people's perception of, and memory for, racially ambiguous faces. Participants saw a morphed target face accompanied by a racial label (Black or White). Later, they were asked to identify the face from a set of two new morphed faces, one more Black and the other more White than the target. As predicted, entity theorists, who believe traits are immutable, perceived and remembered the target face as consistent with the racial label, whereas incremental theorists, who believe traits are malleable, perceived and remembered the face as inconsistent with the racial label. In Study 2, participants also drew the target face more consistently (entity theorists) or less consistently (incremental theorists) with the racial label. Results of both studies confirm that social variables can affect how physical features are seen and remembered.

  16. The effects of nutrition labeling on consumer food choice: a psychological experiment and computational model.

    PubMed

    Helfer, Peter; Shultz, Thomas R

    2014-12-01

    The widespread availability of calorie-dense food is believed to be a contributing cause of an epidemic of obesity and associated diseases throughout the world. One possible countermeasure is to empower consumers to make healthier food choices with useful nutrition labeling. An important part of this endeavor is to determine the usability of existing and proposed labeling schemes. Here, we report an experiment on how four different labeling schemes affect the speed and nutritional value of food choices. We then apply decision field theory, a leading computational model of human decision making, to simulate the experimental results. The psychology experiment shows that quantitative, single-attribute labeling schemes have greater usability than multiattribute and binary ones, and that they remain effective under moderate time pressure. The computational model simulates these psychological results and provides explanatory insights into them. This work shows how experimental psychology and computational modeling can contribute to the evaluation and improvement of nutrition-labeling schemes.

  17. 19 CFR 122.115 - Labeling of cargo.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.115 Labeling of cargo. A warning label, as required by § 18.4(e) of this chapter, shall be attached to all transit air cargo...

  18. Why People Don't Listen to Warnings: With Discussion of Implications for Futurists.

    ERIC Educational Resources Information Center

    Koster, Fran

    The document reviews recent literature on warning processes, evaluates the effectiveness of warnings in changing public policy and personal behavior, and applies warning literature to specific problem areas. Warning is interpreted to include a statement of the problem and a proposed course of action. The document is presented in six parts. Part…

  19. Social Interactions Sparked by Pictorial Warnings on Cigarette Packs.

    PubMed

    Hall, Marissa G; Peebles, Kathryn; Bach, Laura E; Noar, Seth M; Ribisl, Kurt M; Brewer, Noel T

    2015-10-01

    The Message Impact Framework suggests that social interactions may offer smokers the opportunity to process pictorial warnings on cigarette packs more deeply. We aimed to describe adult smokers' social interactions about pictorial cigarette pack warnings in two longitudinal pilot studies. In Pilot Study 1, 30 smokers used cigarette packs with one of nine pictorial warnings for two weeks. In Pilot Study 2, 46 smokers used cigarette packs with one of five pictorial warnings for four weeks. Nearly all smokers (97%/96% in Pilot Study 1/2) talked about the warnings with other people, with the most common people being friends (67%/87%) and spouses/significant others (34%/42%). Pilot Study 2 found that 26% of smokers talked about the warnings with strangers. Discussions about the health effects of smoking and quitting smoking were more frequent during the first week of exposure to pictorial warnings than in the week prior to beginning the study (both p < 0.05). Pictorial warnings sparked social interactions about the warnings, the health effects of smoking, and quitting smoking, indicating that pictorial warnings may act as a social intervention reaching beyond the individual. Future research should examine social interactions as a potential mediator of the impact of pictorial warnings on smoking behavior. PMID:26506363

  20. Social Interactions Sparked by Pictorial Warnings on Cigarette Packs

    PubMed Central

    Hall, Marissa G.; Peebles, Kathryn; Bach, Laura E.; Noar, Seth M.; Ribisl, Kurt M.; Brewer, Noel T.

    2015-01-01

    The Message Impact Framework suggests that social interactions may offer smokers the opportunity to process pictorial warnings on cigarette packs more deeply. We aimed to describe adult smokers’ social interactions about pictorial cigarette pack warnings in two longitudinal pilot studies. In Pilot Study 1, 30 smokers used cigarette packs with one of nine pictorial warnings for two weeks. In Pilot Study 2, 46 smokers used cigarette packs with one of five pictorial warnings for four weeks. Nearly all smokers (97%/96% in Pilot Study 1/2) talked about the warnings with other people, with the most common people being friends (67%/87%) and spouses/significant others (34%/42%). Pilot Study 2 found that 26% of smokers talked about the warnings with strangers. Discussions about the health effects of smoking and quitting smoking were more frequent during the first week of exposure to pictorial warnings than in the week prior to beginning the study (both p < 0.05). Pictorial warnings sparked social interactions about the warnings, the health effects of smoking, and quitting smoking, indicating that pictorial warnings may act as a social intervention reaching beyond the individual. Future research should examine social interactions as a potential mediator of the impact of pictorial warnings on smoking behavior. PMID:26506363

  1. 30 CFR 47.42 - Label contents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Label contents. 47.42 Section 47.42 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.42 Label contents. When an operator...

  2. 30 CFR 47.42 - Label contents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Label contents. 47.42 Section 47.42 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.42 Label contents. When an operator...

  3. 30 CFR 47.42 - Label contents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Label contents. 47.42 Section 47.42 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.42 Label contents. When an operator...

  4. 30 CFR 47.42 - Label contents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Label contents. 47.42 Section 47.42 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.42 Label contents. When an operator...

  5. 30 CFR 47.42 - Label contents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Label contents. 47.42 Section 47.42 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.42 Label contents. When an operator...

  6. The Effects of Symptom Recognition and Diagnostic Labels on Public Beliefs, Emotional Reactions, and Stigmas Associated with Intellectual Disability

    ERIC Educational Resources Information Center

    Scior, Katrina; Connolly, Theresa; Williams, Janice

    2013-01-01

    Labels are firmly rejected by the disability rights movement, yet the complex effects of labeling on lay beliefs are poorly understood. This study examined the effects of labeling on the general public's reactions to people with intellectual disabilities. A sample of 1,233 adult members of the UK general population were randomly presented with…

  7. A comparison of different informative vibrotactile forward collision warnings: does the warning need to be linked to the collision event?

    PubMed

    Gray, Rob; Ho, Cristy; Spence, Charles

    2014-01-01

    Recent research demonstrates that auditory and vibrotactile forward collision warnings presenting a motion signal (e.g., looming or apparent motion across the body surface) can facilitate speeded braking reaction times (BRTs). The purpose of the present study was to expand on this work by directly comparing warning signals in which the motion conveyed was constant across all collision events with signals in which the speed of motion was dependent on the closing velocity (CV). Two experiments were conducted using a simulated car-following task and BRTs were measured. In Experiment 1, increasing intensity (looming) vibrotactile signals were presented from a single tactor attached to the driver's waist. When the increase in intensity was CV-linked, BRTs were significantly faster as compared to a no-warning condition, however, they were not significantly different from constant intensity and CV-independent looming warnings. In Experiment 2, a vertical array of three tactors was used to create motion either towards (upwards) or away (downwards) from the driver's head. When the warning signal presented upwards motion that was CV-linked, BRTs were significantly faster than all other warning types. Downwards warnings led to a significantly higher number of brake activations in false alarm situations as compared to upwards moving warnings. The effectiveness of dynamic tactile collision warnings would therefore appear to depend on both the link between the warning and collision event and on the directionality of the warning signal.

  8. A Comparison of Different Informative Vibrotactile Forward Collision Warnings: Does the Warning Need to Be Linked to the Collision Event?

    PubMed Central

    Gray, Rob; Ho, Cristy; Spence, Charles

    2014-01-01

    Recent research demonstrates that auditory and vibrotactile forward collision warnings presenting a motion signal (e.g., looming or apparent motion across the body surface) can facilitate speeded braking reaction times (BRTs). The purpose of the present study was to expand on this work by directly comparing warning signals in which the motion conveyed was constant across all collision events with signals in which the speed of motion was dependent on the closing velocity (CV). Two experiments were conducted using a simulated car-following task and BRTs were measured. In Experiment 1, increasing intensity (looming) vibrotactile signals were presented from a single tactor attached to the driver's waist. When the increase in intensity was CV-linked, BRTs were significantly faster as compared to a no-warning condition, however, they were not significantly different from constant intensity and CV-independent looming warnings. In Experiment 2, a vertical array of three tactors was used to create motion either towards (upwards) or away (downwards) from the driver's head. When the warning signal presented upwards motion that was CV-linked, BRTs were significantly faster than all other warning types. Downwards warnings led to a significantly higher number of brake activations in false alarm situations as compared to upwards moving warnings. The effectiveness of dynamic tactile collision warnings would therefore appear to depend on both the link between the warning and collision event and on the directionality of the warning signal. PMID:24475225

  9. Potential Effect of Physical Activity Calorie Equivalent Labeling on Parent Fast Food Decisions

    PubMed Central

    Antonelli, Ray

    2015-01-01

    OBJECTIVES: Menu labels displaying food energy in physical activity calorie equivalents (PACE) is a possible strategy to encourage ordering meals with fewer calories and promoting physical activity. Potential effects of such labeling for children have never been examined. METHODS: We conducted a national survey of 1000 parents randomized to 1 of 4 fast food menus: no labels, calories only, calories plus minutes, or calories plus miles needed to walk to burn the calories. Respondents were asked to imagine they were in a fast food restaurant and place an order for their child. At the survey’s conclusion, all respondents were shown a calorie-only label and both PACE labels and asked to rate the likelihood each label would influence them to encourage their child to exercise. RESULTS: We excluded respondents whose meals totaled 0 calories or >4000 calories, leaving 823 parents in the analysis. The mean age of the child for whom the meal was “ordered” was 9.5 years. Parents whose menus displayed no label ordered an average of 1294 calories, whereas those shown calories only, calories plus minutes, or calories plus miles ordered 1066, 1060, and 1099 calories, respectively (P = .0001). Only 20% of parents reported that calories-only labeling would be “very likely” to prompt them to encourage their children to exercise versus 38% for calories plus minutes (P < .0001) and 37% for calories plus miles (P < .0001). CONCLUSIONS: PACE labeling may influence parents’ decisions on what fast food items to order for their children and encourage them to get their children to exercise. PMID:25624379

  10. Effect of labeling on new vegetable dish acceptance in preadolescent children.

    PubMed

    Morizet, David; Depezay, Laurence; Combris, Pierre; Picard, Delphine; Giboreau, Agnès

    2012-10-01

    The aim of this study was to explore the effectiveness of a food-labeling strategy to introduce new versions of foods to children's diets, in natural lunch settings (school canteens). The proposed food involved two different types of vegetables: carrots (very familiar) and broccoli (less familiar), both being prepared and presented for choice in a 'familiar' (known) versus a 'new' (unknown) version. We assessed whether adding a label (either basic or model-related) to new versions of vegetable dishes would increase the likelihood that 8- to 11-year-old children would select the new dishes rather than the familiar versions. In the first condition (no label/control condition), both the familiar and the new versions of the vegetable dishes were presented with absence of any information. In the second condition (basic label condition), the new dish was presented accompanied by a basic label: "new carrot/broccoli recipe". In the third condition (model-related label condition), the new version of the dish was presented with a model-related label: "new carrot/broccoli recipe, Special Mix for Super Heroes". Results showed that children chose significantly more often the familiar version of the dish when no information was given (control condition). The addition of a descriptive label (whether basic or model-related) led to an increased frequency of choice for the new vegetable dish for carrots only, and not for broccoli. This study suggests that adding a label with the vegetable's name can be used to increase children's willingness to select a new version of a vegetable dish instead of a familiar one, at least when the vegetable is familiar to the children (i.e. carrots). PMID:22664298

  11. Communication of emergency public warnings: A social science perspective and state-of-the-art assessment

    SciTech Connect

    Mileti, D.S. ); Sorensen, J.H. )

    1990-08-01

    More than 200 studies of warning systems and warning response were reviewed for this social science perspective and state-of-the-art assessment of communication of emergency public warnings. The major findings are as follows. First, variations in the nature and content of warnings have a large impact on whether or not the public heeds the warning. Relevant factors include the warning source; warning channel; the consistency, credibility, accuracy, and understandability of the message; and the warning frequency. Second, characteristics of the population receiving the warning affect warning response. These include social characteristics such as gender, ethnicity and age, social setting characteristics such as stage of life or family context, psychological characteristics such as fatalism or risk perception, and knowledge characteristics such as experience or training. Third, many current myths about public response to emergency warning are at odds with knowledge derived from field investigations. Some of these myths include the keep it simple'' notion, the cry wolf'' syndrome, public panic and hysteria, and those concerning public willingness to respond to warnings. Finally, different methods of warning the public are not equally effective at providing an alert and notification in different physical and social settings. Most systems can provide a warning given three or more hours of available warning time. Special systems such as tone-alert radios are needed to provide rapid warning. 235 refs., 8 figs., 2 tabs.

  12. Kinetic isotope effects significantly influence intracellular metabolite 13C labeling patterns and flux determination

    PubMed Central

    Wasylenko, Thomas M.; Stephanopoulos, Gregory

    2014-01-01

    Rigorous mathematical modeling of carbon-labeling experiments allows estimation of fluxes through the pathways of central carbon metabolism, yielding powerful information for basic scientific studies as well as for a wide range of applications. However, the mathematical models that have been developed for flux determination from 13C labeling data have commonly neglected the influence of kinetic isotope effects on the distribution of 13C label in intracellular metabolites, as these effects have often been assumed to be inconsequential. We have used measurements of the 13C isotope effects on the pyruvate dehydrogenase enzyme from the literature to model isotopic fractionation at the pyruvate node and quantify the modeling errors expected to result from the assumption that isotope effects are negligible. We show that under some conditions kinetic isotope effects have a significant impact on the 13C labeling patterns of intracellular metabolites, and the errors associated with neglecting isotope effects in 13C-metabolic flux analysis models can be comparable in size to measurement errors associated with GC–MS. Thus, kinetic isotope effects must be considered in any rigorous assessment of errors in 13C labeling data, goodness-of-fit between model and data, confidence intervals of estimated metabolic fluxes, and statistical significance of differences between estimated metabolic flux distributions. PMID:23828762

  13. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness

    PubMed Central

    2013-01-01

    Out-of-date or incomplete drug product labeling information may increase the risk of otherwise preventable adverse drug events. In recognition of these concerns, the United States Federal Drug Administration (FDA) requires drug product labels to include specific information. Unfortunately, several studies have found that drug product labeling fails to keep current with the scientific literature. We present a novel approach to addressing this issue. The primary goal of this novel approach is to better meet the information needs of persons who consult the drug product label for information on a drug’s efficacy, effectiveness, and safety. Using FDA product label regulations as a guide, the approach links drug claims present in drug information sources available on the Semantic Web with specific product label sections. Here we report on pilot work that establishes the baseline performance characteristics of a proof-of-concept system implementing the novel approach. Claims from three drug information sources were linked to the Clinical Studies, Drug Interactions, and Clinical Pharmacology sections of the labels for drug products that contain one of 29 psychotropic drugs. The resulting Linked Data set maps 409 efficacy/effectiveness study results, 784 drug-drug interactions, and 112 metabolic pathway assertions derived from three clinically-oriented drug information sources (ClinicalTrials.gov, the National Drug File – Reference Terminology, and the Drug Interaction Knowledge Base) to the sections of 1,102 product labels. Proof-of-concept web pages were created for all 1,102 drug product labels that demonstrate one possible approach to presenting information that dynamically enhances drug product labeling. We found that approximately one in five efficacy/effectiveness claims were relevant to the Clinical Studies section of a psychotropic drug product, with most relevant claims providing new information. We also identified several cases where all of the drug

  14. Can words heal? Using affect labeling to reduce the effects of unpleasant cues on symptom reporting

    PubMed Central

    Constantinou, Elena; Van Den Houte, Maaike; Bogaerts, Katleen; Van Diest, Ilse; Van den Bergh, Omer

    2014-01-01

    Processing unpleasant affective cues induces elevated momentary symptom reports, especially in persons with high levels of symptom reporting in daily life. The present study aimed to examine whether applying an emotion regulation strategy, i.e. affect labeling, can inhibit these emotion influences on symptom reporting. Student participants (N = 61) with varying levels of habitual symptom reporting completed six picture viewing trials of homogeneous valence (three pleasant, three unpleasant) under three conditions: merely viewing, emotional labeling, or content (non-emotional) labeling. Affect ratings and symptom reports were collected after each trial. Participants completed a motor inhibition task and self-control questionnaires as indices of their inhibitory capacities. Heart rate variability was also measured. Labeling, either emotional or non-emotional, significantly reduced experienced affect, as well as the elevated symptoms reports observed after unpleasant picture viewing. These labeling effects became more pronounced with increasing levels of habitual symptom reporting, suggesting a moderating role of the latter variable, but did not correlate with any index of general inhibitory capacity. Our findings suggest that using an emotion regulation strategy, such as labeling emotional stimuli, can reverse the effects of unpleasant stimuli on symptom reporting and that such strategies can be especially beneficial for individuals suffering from medically unexplained physical symptoms. PMID:25101048

  15. Evolution of tsunami warning systems and products.

    PubMed

    Bernard, Eddie; Titov, Vasily

    2015-10-28

    Each year, about 60 000 people and $4 billion (US$) in assets are exposed to the global tsunami hazard. Accurate and reliable tsunami warning systems have been shown to provide a significant defence for this flooding hazard. However, the evolution of warning systems has been influenced by two processes: deadly tsunamis and available technology. In this paper, we explore the evolution of science and technology used in tsunami warning systems, the evolution of their products using warning technologies, and offer suggestions for a new generation of warning products, aimed at the flooding nature of the hazard, to reduce future tsunami impacts on society. We conclude that coastal communities would be well served by receiving three standardized, accurate, real-time tsunami warning products, namely (i) tsunami energy estimate, (ii) flooding maps and (iii) tsunami-induced harbour current maps to minimize the impact of tsunamis. Such information would arm communities with vital flooding guidance for evacuations and port operations. The advantage of global standardized flooding products delivered in a common format is efficiency and accuracy, which leads to effectiveness in promoting tsunami resilience at the community level.

  16. Evolution of tsunami warning systems and products.

    PubMed

    Bernard, Eddie; Titov, Vasily

    2015-10-28

    Each year, about 60 000 people and $4 billion (US$) in assets are exposed to the global tsunami hazard. Accurate and reliable tsunami warning systems have been shown to provide a significant defence for this flooding hazard. However, the evolution of warning systems has been influenced by two processes: deadly tsunamis and available technology. In this paper, we explore the evolution of science and technology used in tsunami warning systems, the evolution of their products using warning technologies, and offer suggestions for a new generation of warning products, aimed at the flooding nature of the hazard, to reduce future tsunami impacts on society. We conclude that coastal communities would be well served by receiving three standardized, accurate, real-time tsunami warning products, namely (i) tsunami energy estimate, (ii) flooding maps and (iii) tsunami-induced harbour current maps to minimize the impact of tsunamis. Such information would arm communities with vital flooding guidance for evacuations and port operations. The advantage of global standardized flooding products delivered in a common format is efficiency and accuracy, which leads to effectiveness in promoting tsunami resilience at the community level. PMID:26392620

  17. Evolution of tsunami warning systems and products

    PubMed Central

    Bernard, Eddie; Titov, Vasily

    2015-01-01

    Each year, about 60 000 people and $4 billion (US$) in assets are exposed to the global tsunami hazard. Accurate and reliable tsunami warning systems have been shown to provide a significant defence for this flooding hazard. However, the evolution of warning systems has been influenced by two processes: deadly tsunamis and available technology. In this paper, we explore the evolution of science and technology used in tsunami warning systems, the evolution of their products using warning technologies, and offer suggestions for a new generation of warning products, aimed at the flooding nature of the hazard, to reduce future tsunami impacts on society. We conclude that coastal communities would be well served by receiving three standardized, accurate, real-time tsunami warning products, namely (i) tsunami energy estimate, (ii) flooding maps and (iii) tsunami-induced harbour current maps to minimize the impact of tsunamis. Such information would arm communities with vital flooding guidance for evacuations and port operations. The advantage of global standardized flooding products delivered in a common format is efficiency and accuracy, which leads to effectiveness in promoting tsunami resilience at the community level. PMID:26392620

  18. More effective nutrition label formats are not necessarily preferred.

    PubMed

    Levy, A S; Fein, S B; Schucker, R E

    1992-10-01

    An experimental design was used to compare performance and preference for five nutrition label formats. Four performance measures--accuracy and false-positives in identifying nutrient differences, time required, and correctness in judging which product was more nutritious--were derived from a product-comparison task. A sample of 1,460 food shoppers over 18 years old was recruited by a shopping mall-intercept method. Results of the study demonstrated that preferences and performance do not necessarily agree. The Control format, which had no nutrition profile information, performed the best but was liked the least. The Adjectival format, which provided nutrition profile information in the form of descriptive adjectives, was the most preferred. Results also showed that listing Daily Reference Values or nutrition profile aids increased preference but either did not affect performance or decreased it, depending on the specific aid and performance measure. Formats that some subjects liked for having adequate information others disliked for being hard to use. Formats that some subjects liked for being easy to use others disliked for having inadequate information. Age, education, and race were related to all of the performance measures except judgment of relative nutrition. Only gender was related to preference. Results of the study are useful as guidance for the development of consumer education materials. PMID:1401661

  19. Effect of tumor mass and antigenic nature on the biodistribution of labeled monoclonal antibodies in mice

    SciTech Connect

    Watanabe, Y.; Endo, K.; Koizumi, M.; Kawamura, Y.; Saga, T.; Sakahara, H.; Kuroki, M.; Matsuoka, Y.; Konishi, J.

    1989-06-01

    The effect of tumor mass and antigenic nature on the biodistribution of 111In- and 125I-labeled monoclonal antibodies (MoAbs) was studied using F(ab')2 fragments of three representative anti-tumor MoAbs and SW1116 human colorectal carcinoma grown in nude mice. The 19-9, F33-104 anti-CEA, and 17-1A MoAbs showed specific binding to SW1116 cells. The former two MoAbs recognize circulating CA 19-9 with molecular weights of more than 5,000,000 and CEA of Mr 170,000-180,000, respectively, whereas 17-1A reacts with a nonshedding antigen. Both percentage injected dose per gram tumor and tumor-to-blood ratios were inversely proportional to the tumor mass in nude mice administered 111In- and 125I-labeled 19-9, but liver uptake increased as tumor size increased. Analysis of serum samples and tumor homogenates demonstrated the presence of a high-molecular-weight species, probably due to the antibody binding to CA 19-9. In the case of 111In-labeled anti-CEA MoAb, tumor uptake also decreased and liver uptake increased with tumor size, but this effect was less obvious than that of 19-9. In contrast, tumor and liver uptake of 125I-labeled anti-CEA MoAb, 111In- and 125I-labeled 17-1A and control antibodies were independent of tumor mass. The absolute tumor uptake and tumor-to-blood ratios of all 125I-labeled antibodies were lower than those of the 111In-labeled ones. And the effect of tumor mass was also weaker with 125I-labeled antibodies, probably due to in vivo dehalogenation. These results indicate that the effect of tumor size on the incorporation of labeled MoAb into tumors is dependent on the antigenic nature to be targeted and/or radionuclides used for labeling and that high concentrations of circulating high molecular weight antigens may limit in vivo use of MoAb conjugates.

  20. 30 CFR 47.41 - Requirement for container labels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Requirement for container labels. 47.41 Section... TRAINING HAZARD COMMUNICATION (HazCom) Container Labels and Other Forms of Warning § 47.41 Requirement for container labels. (a) The operator must ensure that each container of a hazardous chemical has a label. If...

  1. Effect of In-Vehicle Audio Warning System on Driver’s Speed Control Performance in Transition Zones from Rural Areas to Urban Areas

    PubMed Central

    Yan, Xuedong; Wang, Jiali; Wu, Jiawei

    2016-01-01

    Speeding is a major contributing factor to traffic crashes and frequently happens in areas where there is a mutation in speed limits, such as the transition zones that connect urban areas from rural areas. The purpose of this study is to investigate the effects of an in-vehicle audio warning system and lit speed limit sign on preventing drivers’ speeding behavior in transition zones. A high-fidelity driving simulator was used to establish a roadway network with the transition zone. A total of 41 participants were recruited for this experiment, and the driving speed performance data were collected from the simulator. The experimental results display that the implementation of the audio warning system could significantly reduce drivers’ operating speed before they entered the urban area, while the lit speed limit sign had a minimal effect on improving the drivers’ speed control performance. Without consideration of different types of speed limit signs, it is found that male drivers generally had a higher operating speed both upstream and in the transition zones and have a larger maximum deceleration for speed reduction than female drivers. Moreover, the drivers who had medium-level driving experience had the higher operating speed and were more likely to have speeding behaviors in the transition zones than those who had low-level and high-level driving experience in the transition zones. PMID:27347990

  2. Effect of Fluorescently Labeling Protein Probes on Kinetics of Protein-Ligand Reactions

    PubMed Central

    Sun, Y.S.; Landry, J.P.; Fei, Y.Y.; Luo, J.T.; Wang, X.B.; Lam, K.S.

    2009-01-01

    We studied the effect of fluorescently labeling proteins on protein-ligand reactions. Un-labeled ligands (streptavidin-binding peptides and rabbit immunoglobulin G (IgG) as antigen targets) are immobilized on epoxy-functionalized glass slides. Unlabeled and Cy3-labeled protein probes from the same batch (streptavidin and goat antibodies) subsequently react with the surface-immobilized targets. By monitoring in situ the surface mass density change using an oblique-incidence reflectivity difference scanning microscope (a label-free detector), we measured kon and koff for streptavidin-peptide reactions and antibody-antigen reaction. We found that (1) equilibrium dissociation constants, defined as KD = koff/kon, for streptavidin-peptide reactions increases by a factor of 3 ~ 4 when the solution-phase streptavidin is labeled with Cy3 dye; and (2) KD for reactions of solution-phase goat anti-rabbit antibodies with rabbit IgG targets also change significantly when the goat antibodies are labeled with Cy3 dye. PMID:18991423

  3. Required warnings for cigarette packages and advertisements. Final rule.

    PubMed

    2011-06-22

    The Food and Drug Administration (FDA) is amending its regulations to add a new requirement for the display of health warnings on cigarette packages and in cigarette advertisements. This rule implements a provision of the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act) that requires FDA to issue regulations requiring color graphics, depicting the negative health consequences of smoking, to accompany the nine new textual warning statements required under the Tobacco Control Act. The Tobacco Control Act amends the Federal Cigarette Labeling and Advertising Act (FCLAA) to require each cigarette package and advertisement to bear one of nine new textual warning statements. This final rule specifies the color graphic images that must accompany each of the nine new textual warning statements. PMID:21696017

  4. DETECTION OR WARNING SYSTEM

    DOEpatents

    Tillman, J E

    1953-10-20

    This patent application describes a sensitive detection or protective system capable of giving an alarm or warning upon the entrance or intrusion of any body into a defined area or zone protected by a radiation field of suitable direction or extent.

  5. GEO Label Web Services for Dynamic and Effective Communication of Geospatial Metadata Quality

    NASA Astrophysics Data System (ADS)

    Lush, Victoria; Nüst, Daniel; Bastin, Lucy; Masó, Joan; Lumsden, Jo

    2014-05-01

    We present demonstrations of the GEO label Web services and their integration into a prototype extension of the GEOSS portal (http://scgeoviqua.sapienzaconsulting.com/web/guest/geo_home), the GMU portal (http://gis.csiss.gmu.edu/GADMFS/) and a GeoNetwork catalog application (http://uncertdata.aston.ac.uk:8080/geonetwork/srv/eng/main.home). The GEO label is designed to communicate, and facilitate interrogation of, geospatial quality information with a view to supporting efficient and effective dataset selection on the basis of quality, trustworthiness and fitness for use. The GEO label which we propose was developed and evaluated according to a user-centred design (UCD) approach in order to maximise the likelihood of user acceptance once deployed. The resulting label is dynamically generated from producer metadata in ISO or FDGC format, and incorporates user feedback on dataset usage, ratings and discovered issues, in order to supply a highly informative summary of metadata completeness and quality. The label was easily incorporated into a community portal as part of the GEO Architecture Implementation Programme (AIP-6) and has been successfully integrated into a prototype extension of the GEOSS portal, as well as the popular metadata catalog and editor, GeoNetwork. The design of the GEO label was based on 4 user studies conducted to: (1) elicit initial user requirements; (2) investigate initial user views on the concept of a GEO label and its potential role; (3) evaluate prototype label visualizations; and (4) evaluate and validate physical GEO label prototypes. The results of these studies indicated that users and producers support the concept of a label with drill-down interrogation facility, combining eight geospatial data informational aspects, namely: producer profile, producer comments, lineage information, standards compliance, quality information, user feedback, expert reviews, and citations information. These are delivered as eight facets of a wheel

  6. Modeling warning times for the Israel's earthquake early warning system

    NASA Astrophysics Data System (ADS)

    Pinsky, Vladimir

    2015-01-01

    In June 2012, the Israeli government approved the offer of the creation of an earthquake early warning system (EEWS) that would provide timely alarms for schools and colleges in Israel. A network configuration was chosen, consisting of a staggered line of ˜100 stations along the main regional faults: the Dead Sea fault and the Carmel fault, and an additional ˜40 stations spread more or less evenly over the country. A hybrid approach to the EEWS alarm was suggested, where a P-wave-based system will be combined with the S-threshold method. The former utilizes first arrivals to several stations closest to the event for prompt location and determination of the earthquake's magnitude from the first 3 s of the waveform data. The latter issues alarms, when the acceleration of the surface movement exceeds a threshold for at least two neighboring stations. The threshold will be chosen to be a peak acceleration level corresponding to a magnitude 5 earthquake at a short distance range (5-10 km). The warning times or lead times, i.e., times between the alarm signal arrival and arrival of the damaging S-waves, are considered for the P, S, and hybrid EEWS methods. For each of the approaches, the P- and the S-wave travel times and the alarm times were calculated using a standard 1D velocity model and some assumptions regarding the EEWS data latencies. Then, a definition of alarm effectiveness was introduced as a measure of the trade-off between the warning time and the shaking intensity. A number of strong earthquake scenarios, together with anticipated shaking intensities at important targets, namely cities with high populations, are considered. The scenarios demonstrated in probabilistic terms how the alarm effectiveness varies depending on the target distance from the epicenter and event magnitude.

  7. Modeling warning times for the Israel's earthquake early warning system

    NASA Astrophysics Data System (ADS)

    Pinsky, Vladimir

    2014-09-01

    In June 2012, the Israeli government approved the offer of the creation of an earthquake early warning system (EEWS) that would provide timely alarms for schools and colleges in Israel. A network configuration was chosen, consisting of a staggered line of ˜100 stations along the main regional faults: the Dead Sea fault and the Carmel fault, and an additional ˜40 stations spread more or less evenly over the country. A hybrid approach to the EEWS alarm was suggested, where a P-wave-based system will be combined with the S-threshold method. The former utilizes first arrivals to several stations closest to the event for prompt location and determination of the earthquake's magnitude from the first 3 s of the waveform data. The latter issues alarms, when the acceleration of the surface movement exceeds a threshold for at least two neighboring stations. The threshold will be chosen to be a peak acceleration level corresponding to a magnitude 5 earthquake at a short distance range (5-10 km). The warning times or lead times, i.e., times between the alarm signal arrival and arrival of the damaging S-waves, are considered for the P, S, and hybrid EEWS methods. For each of the approaches, the P- and the S-wave travel times and the alarm times were calculated using a standard 1D velocity model and some assumptions regarding the EEWS data latencies. Then, a definition of alarm effectiveness was introduced as a measure of the trade-off between the warning time and the shaking intensity. A number of strong earthquake scenarios, together with anticipated shaking intensities at important targets, namely cities with high populations, are considered. The scenarios demonstrated in probabilistic terms how the alarm effectiveness varies depending on the target distance from the epicenter and event magnitude.

  8. Effect of labeling density and time post labeling on quality of antibody-based super resolution microscopy images

    NASA Astrophysics Data System (ADS)

    Bittel, Amy M.; Saldivar, Isaac; Dolman, Nicholas; Nickerson, Andrew K.; Lin, Li-Jung; Nan, Xiaolin; Gibbs, Summer L.

    2015-03-01

    Super resolution microscopy (SRM) has overcome the historic spatial resolution limit of light microscopy, enabling fluorescence visualization of intracellular structures and multi-protein complexes at the nanometer scale. Using single-molecule localization microscopy, the precise location of a stochastically activated population of photoswitchable fluorophores is determined during the collection of many images to form a single image with resolution of ~10-20 nm, an order of magnitude improvement over conventional microscopy. One of the key factors in achieving such resolution with single-molecule SRM is the ability to accurately locate each fluorophore while it emits photons. Image quality is also related to appropriate labeling density of the entity of interest within the sample. While ease of detection improves as entities are labeled with more fluorophores and have increased fluorescence signal, there is potential to reduce localization precision, and hence resolution, with an increased number of fluorophores that are on at the same time in the same relative vicinity. In the current work, fixed microtubules were antibody labeled using secondary antibodies prepared with a range of Alexa Fluor 647 conjugation ratios to compare image quality of microtubules to the fluorophore labeling density. It was found that image quality changed with both the fluorophore labeling density and time between completion of labeling and performance of imaging study, with certain fluorophore to protein ratios giving optimal imaging results.

  9. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must...

  10. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must...

  11. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must...

  12. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must...

  13. 40 CFR 156.66 - Child hazard warning.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Child hazard warning. 156.66 Section... LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Human Hazard and Precautionary Statements § 156.66 Child... Out of Reach of Children.” That statement, or any alternative statement approved by EPA, must...

  14. Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors

    NASA Astrophysics Data System (ADS)

    Star, Alexander; Tu, Eugene; Niemann, Joseph; Gabriel, Jean-Christophe P.; Joiner, C. Steve; Valcke, Christian

    2006-01-01

    We report carbon nanotube network field-effect transistors (NTNFETs) that function as selective detectors of DNA immobilization and hybridization. NTNFETs with immobilized synthetic oligonucleotides have been shown to specifically recognize target DNA sequences, including H63D single-nucleotide polymorphism (SNP) discrimination in the HFE gene, responsible for hereditary hemochromatosis. The electronic responses of NTNFETs upon single-stranded DNA immobilization and subsequent DNA hybridization events were confirmed by using fluorescence-labeled oligonucleotides and then were further explored for label-free DNA detection at picomolar to micromolar concentrations. We have also observed a strong effect of DNA counterions on the electronic response, thus suggesting a charge-based mechanism of DNA detection using NTNFET devices. Implementation of label-free electronic detection assays using NTNFETs constitutes an important step toward low-cost, low-complexity, highly sensitive and accurate molecular diagnostics. hemochromatosis | SNP | biosensor

  15. Communicating risk information and warnings

    USGS Publications Warehouse

    Mileti, D. S.

    1990-01-01

    Major advances have occurred over the last 20 years about how to effectively communicate risk information and warnings to the public. These lessons have been hard won. Knowledge has mounted on the finding from social scientific studies of risk communication failures, successes and those which fell somewhere in between. Moreover, the last 2 decades have borne witness to the brith, cultivation, and blossoming of information sharing between those physical scientists who discover new information about risk and those communcation scientists who trace its diffusion and then measure pbulic reaction. 

  16. Designing interactive consumer products: utility of paper prototypes and effectiveness of enhanced control labelling.

    PubMed

    Sauer, Juergen; Franke, Holger; Ruettinger, Bruno

    2008-01-01

    The studies reported here examined differences in user behaviour when presented with a low-fidelity paper prototype compared to fully operational product, and evaluated the effectiveness of different types of enhanced labelling of controls. In the first study with a paper prototype, 30 users of high-pressure washers were asked to choose the settings of the temperature control for different cleaning objects, comparing standard with information-enriched control labelling. In the second study, 34 users operated a real high-pressure washer with different forms of control labelling. The results of both studies provided evidence for some benefits of an information-enriched control labelling over traditional temperature-centred controls labelling. Furthermore, a comparative analysis of the data of the two studies suggested that low-fidelity paper prototypes may have to be used with caution. Therefore, designers need to be aware that the behavioural effects induced by different design modifications may be overestimated when using paper prototypes. The implications of the findings are discussed within the framework of an enlarged concept of fidelity.

  17. Effects of different discount levels on healthy products coupled with a healthy choice label, special offer label or both: results from a web-based supermarket experiment

    PubMed Central

    2013-01-01

    Background Two strategies commonly recommended to improve population diets include food labels and food taxes/subsidies. The aim of this study was to examine the effects of both strategies separately and in combination. Findings An experiment with a 3x3 factorial design was conducted, including: three levels of price reduction (10%; 25%; and 50%) x three labels (‘special offer’, ‘healthy choice’ and ‘special offer & healthy choice’) on healthy foods defined following the Choices front-of-pack nutrition label. N = 109 participants completed the experiment by conducting a typical weekly shop for their household at a three-dimensional web-based supermarket. Data were analysed using analysis of covariance. Participants receiving a 50% price discount purchased significantly more healthy foods for their household in a typical weekly shop than the 10% discount (+8.7 items; 95%CI = 3.8-13.6) and the 25% discount group (+7.7 items; 95%CI = 2.74 – 12.6). However, the proportion of healthy foods was not significantly higher and the discounts lead to an increased amount of energy purchased. No significant effects of the labels were found. Conclusion This study brings some relevant insights into the effects of price discounts on healthier foods coupled with different labels and shows that price effects over shadowed food labels. However, price discounts seem to have ambiguous effects; they do encourage the purchase of healthy products, but also lead to increased energy purchases. More research is needed to examine how pricing strategies can work in directing consumers towards interchanging unhealthier options for healthier alternatives. PMID:23680347

  18. Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions.

    PubMed

    Sun, Y S; Landry, J P; Fei, Y Y; Zhu, X D; Luo, J T; Wang, X B; Lam, K S

    2008-12-01

    We studied the effect of fluorescently labeling proteins on protein-ligand reactions. Unlabeled ligands (streptavidin-binding peptides and rabbit immunoglobulin G (IgG) as antigen targets) are immobilized on epoxy-functionalized glass slides. Unlabeled and Cy3-labeled protein probes from the same batch (streptavidin and goat antibodies) subsequently react with the surface-immobilized targets. By monitoring in situ the surface mass density change using an oblique-incidence reflectivity difference scanning microscope (a label-free detector), we measured k(on) and k(off) for streptavidin-peptide reactions and antibody-antigen reaction. We found that (1) equilibrium dissociation constants, defined as K(D) = k(off)/k(on), for streptavidin-peptide reactions increases by a factor of 3-4 when the solution-phase streptavidin is labeled with Cy3 dye and (2) K(D) for reactions of solution-phase goat anti-rabbit antibodies with rabbit IgG targets also change significantly when the goat antibodies are labeled with Cy3 dye. PMID:18991423

  19. The effect of fluorescent labeling on α-synuclein fibril morphology.

    PubMed

    Mučibabić, M; Apetri, M M; Canters, G W; Aartsma, T J

    2016-10-01

    The misfolding and aggregation of a small, natively unfolded protein α-synuclein (α-syn) is presumably an important factor in the development of Parkinson's disease. However, the mechanism of α-syn aggregation into amyloid fibrils and their morphology are not well understood. To elucidate the aggregation kinetics and the morphology of aggregates by the use of fluorescent techniques the protein needs to be suitably labeled. In this study, using atomic force microscopy, we demonstrate a significant effect of fluorescent labels on the α-syn fibrillization process. We studied in detail the morphology of α-syn aggregates as a function of the composition of mixtures of labeled and wild type (WT) α-syn in solution using different types of fluorescent dyes. Although the overall charge of the fluorophores we used and their chemical structure varied significantly, the morphology of α-syn fibrils changed in a similar way in all cases. The increase in the fraction of labeled α-syn in solution led to shortening of the fibrils as compared to those from WT-only α-syn, whereas the height of the fibrils remained mainly unaffected. The twisted fibril morphology observed in the WT and A140C α-syn mutant completely disappeared when the A140C α-syn mutant was 100% fluorescently labeled.

  20. Heavy atom labeled nucleotides for measurement of kinetic isotope effects.

    PubMed

    Weissman, Benjamin P; Li, Nan-Sheng; York, Darrin; Harris, Michael; Piccirilli, Joseph A

    2015-11-01

    Experimental analysis of kinetic isotope effects represents an extremely powerful approach for gaining information about the transition state structure of complex reactions not available through other methodologies. The implementation of this approach to the study of nucleic acid chemistry requires the synthesis of nucleobases and nucleotides enriched for heavy isotopes at specific positions. In this review, we highlight current approaches to the synthesis of nucleic acids enriched site specifically for heavy oxygen and nitrogen and their application in heavy atom isotope effect studies. This article is part of a special issue titled: Enzyme Transition States from Theory and Experiment.

  1. Kinetic effects on signal normalization in oligonucleotide microchips with labeled immobilized probes.

    PubMed

    Pan'kov, S V; Chechetkin, V R; Somova, O G; Antonova, O V; Moiseeva, O V; Prokopenko, D V; Yurasov, R A; Gryadunov, D A; Chudinov, A V

    2009-10-01

    Among various factors affecting operation of oligonucleotide microchips, the variations in concentration and in homogeneous distribution of immobilized probes over the cells are one of the most important. The labeling of immobilized probes ensures the complete current monitoring on the probe distribution and is reliable and convenient. Using hydrogel-based oligonucleotide microchips, the applicability of Cy3-labeled immobilized probes for quality control and signal normalization after hybridization with Cy5-labeled target DNA was investigated. This study showed that proper signal normalization should be different in thermodynamic conditions and in transient regime with hybridization far from saturation. This kinetic effect holds for both hydrogel-based and surface oligonucleotide microchips. Besides proving basic features, the technique was assessed on a sampling batch of 50 microchips developed for identifying mutations responsible for rifampicin and isoniazid resistance of Mycobacterium tuberculosis.

  2. The Effects of Verbal Labels and Vocabulary Skill on Memory and Suggestibility

    ERIC Educational Resources Information Center

    Kulkofsky, Sarah

    2010-01-01

    The current study investigated the effectiveness of the verbal labels procedure (D. A. Brown & M. E. Pipe, 2003) to improve preschool children's responses to direct open-ended and misleading questions. Additionally, children's vocabulary skill was considered. Eighty-seven preschool children from diverse backgrounds were interviewed about a unique…

  3. Effects of Labeling on Preschoolers' Explicit False Belief Performance: Outcomes of Cognitive Flexibility or Inhibitory Control?

    ERIC Educational Resources Information Center

    Low, Jason; Simpson, Samantha

    2012-01-01

    Executive function mechanisms underpinning language-related effects on theory of mind understanding were examined in a sample of 165 preschoolers. Verbal labels were manipulated to identify relevant perspectives on an explicit false belief task. In Experiment 1 with 4-year-olds (N = 74), false belief reasoning was superior in the fully and…

  4. The Differential Effects of Labelling: How Do "Dyslexia" and "Reading Difficulties" Affect Teachers' Beliefs

    ERIC Educational Resources Information Center

    Gibbs, Simon; Elliott, Julian

    2015-01-01

    This paper reports a survey of primary school teachers' beliefs about working with poor readers. The primary research question was "does the way difficulties with reading are labelled affect the teachers' beliefs about their ability to intervene effectively?" An opportunity sample of teachers was surveyed using 2 questionnaires. One…

  5. The Effects of Alternative Study Guide Labels on Testing in Developmental Reading

    ERIC Educational Resources Information Center

    Buckley, Shellie Calhoun

    2012-01-01

    Methods and teaching tools have been researched to determine if they prove to be successful in effectively teaching the underprepared. This study was conducted to compare the differences in the utilization of alternative labeling on study guides to determine if the usage affects the outcome on participant's test scores. A quasi-experimental…

  6. 76 FR 30093 - Effectiveness Indications Statements in Veterinary Biologics Labeling; Notice of Public Meeting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... meeting to discuss a draft guideline (concept paper) concerning effectiveness indications statements in veterinary biologics labeling. We are also making the concept paper available for review and comment. DATES... National Centers for Animal Health, 1920 Dayton Avenue, Ames, IA. You may submit comments on the...

  7. Attitudes Toward Retarded Children: Effects of Labeling and Behavioral Aggressiveness. Volume 4, Number 74.

    ERIC Educational Resources Information Center

    Gottlieb, Jay

    Effects of the label "mentally retarded" on attitudes of peers were examined among 48 third grade pupils. Half of the Ss were shown a videotape of an actor displaying acting out behavior, while the remaining Ss were shown a videotape with the same actor engaging in passive behavior. Half of the Ss in each group were told that the actor was a…

  8. Effects of Picture Labeling on Science Text Processing and Learning: Evidence from Eye Movements

    ERIC Educational Resources Information Center

    Mason, Lucia; Pluchino, Patrik; Tornatora, Maria Caterina

    2013-01-01

    This study investigated the effects of reading a science text illustrated by either a labeled or unlabeled picture. Both the online process of reading the text and the offline conceptual learning from the text were examined. Eye-tracking methodology was used to trace text and picture processing through indexes of first- and second-pass reading or…

  9. Longer term impact of cigarette package warnings in Australia compared with the United Kingdom and Canada

    PubMed Central

    Li, Lin; Borland, Ron; Yong, Hua; Cummings, Kenneth M.; Thrasher, James F.; Hitchman, Sara C.; Fong, Geoffrey T.; Hammond, David; Bansal-Travers, Maansi

    2015-01-01

    This study examines the effects of different cigarette package warnings in Australia, Canada and the United Kingdom up to 5 years post-implementation. The data came from the International Tobacco Control Surveys. Measures included salience of warnings, cognitive responses, forgoing cigarettes and avoiding warnings. Although salience of the UK warnings was higher than the Australian and Canadian pictorial warnings, this did not lead to greater levels of cognitive reactions, forgoing or avoiding. There was no difference in ratings between the Australian and UK warnings for cognitive responses and forgoing, but the Canadian warnings were responded to more strongly. Avoidance of the Australian warnings was greater than to UK ones, but less than to the Canadian warnings. The impact of warnings declined over time in all three countries. Declines were comparable between Australia and the United Kingdom on all measures except avoiding, where Australia had a greater rate of decline; and for salience where the decline was slower in Canada. Having two rotating sets of warnings does not appear to reduce wear-out over a single set of warnings. Warning size may be more important than warning type in preventing wear-out, although both probably contribute interactively. PMID:25492056

  10. Cigarette packaging and health warnings: the impact of plain packaging and message framing on young smokers

    PubMed Central

    Mays, Darren; Niaura, Raymond S.; Evans, W. Douglas; Hammond, David; Luta, George; Tercyak, Kenneth P.

    2014-01-01

    Objective This study examined the impact of pictorial cigarette warning labels, warning label message framing, and plain cigarette packaging on young adult smokers’ motivation to quit. Methods Smokers ages 18–30 (n=740) from a consumer research panel were randomized to one of four experimental conditions where they viewed online images of 4 cigarette packs with warnings about lung disease, cancer, stroke/heart disease, and death, respectively. Packs differed across conditions by warning message framing (gain versus loss) and packaging (branded versus plain). Measures captured demographics, smoking behavior, covariates, and motivation to quit in response to cigarette packs. Results Pictorial warnings about lung disease and cancer generated the strongest motivation to quit across conditions. Adjusting for pre-test motivation and covariates, a message framing by packaging interaction revealed gain-framed warnings on plain packs generated greater motivation to quit for lung disease, cancer, and mortality warnings (p < 0.05), compared with loss-framed warnings on plain packs. Conclusions Warnings combining pictorial depictions of smoking-related health risks with text-based messages about how quitting reduces risks may achieve better outcomes among young adults, especially in countries considering or implementing plain packaging regulations. PMID:24420310

  11. Human Response to Emergency Warning

    NASA Astrophysics Data System (ADS)

    Sorensen, J.

    2009-12-01

    Almost every day people evacuate from their homes, businesses or other sites, even ships, in response to actual or predicted threats or hazards. Evacuation is the primary protective action utilized in large-scale emergencies such as hurricanes, floods, tornados, tsunamis, volcanic eruptions, or wildfires. Although often precautionary, protecting human lives by temporally relocating populations before or during times of threat remains a major emergency management strategy. One of the most formidable challenges facing emergency officials is evacuating residents for a fast-moving and largely unpredictable event such as a wildfire or a local tsunami. How to issue effective warnings to those at risk in time for residents to take appropriate action is an on-going problem. To do so, some communities have instituted advanced communications systems that include reverse telephone call-down systems or other alerting systems to notify at-risk residents of imminent threats. This presentation examines the effectiveness of using reverse telephone call-down systems for warning San Diego residents of wildfires in the October of 2007. This is the first systematic study conducted on this topic and is based on interviews with 1200 households in the evacuation areas.

  12. Rock Music Gets a Label.

    ERIC Educational Resources Information Center

    Cutietta, Robert

    1986-01-01

    A group called Parents Music Resource Center (PMRC) has captured the media spotlight with a proposal to have warning labels placed on music albums containing sexually explicit or violent lyrics. Major record companies have agreed to a version of the PMRC's demands for a one-year trial period, beginning in 1986. (RM)

  13. 42 CFR 84.257 - Labeling requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Labeling requirements. (a) A warning shall be placed on the label of each gas mask, chemical-cartridge... performance of any gas mask, chemical-cartridge respirator, or powered air-purifying respirator approved under... this subpart shall be specified as follows: Chemical-cartridge respirator 1 hour. Gas mask 4...

  14. 42 CFR 84.257 - Labeling requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Labeling requirements. (a) A warning shall be placed on the label of each gas mask, chemical-cartridge... performance of any gas mask, chemical-cartridge respirator, or powered air-purifying respirator approved under... this subpart shall be specified as follows: Chemical-cartridge respirator 1 hour. Gas mask 4...

  15. 42 CFR 84.257 - Labeling requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Labeling requirements. (a) A warning shall be placed on the label of each gas mask, chemical-cartridge... performance of any gas mask, chemical-cartridge respirator, or powered air-purifying respirator approved under... this subpart shall be specified as follows: Chemical-cartridge respirator 1 hour. Gas mask 4...

  16. 42 CFR 84.257 - Labeling requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Labeling requirements. (a) A warning shall be placed on the label of each gas mask, chemical-cartridge... performance of any gas mask, chemical-cartridge respirator, or powered air-purifying respirator approved under... this subpart shall be specified as follows: Chemical-cartridge respirator 1 hour. Gas mask 4...

  17. 42 CFR 84.257 - Labeling requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Labeling requirements. (a) A warning shall be placed on the label of each gas mask, chemical-cartridge... performance of any gas mask, chemical-cartridge respirator, or powered air-purifying respirator approved under... this subpart shall be specified as follows: Chemical-cartridge respirator 1 hour. Gas mask 4...

  18. Effect of warning symbols in combination with education on the frequency of erroneously crushing medication in nursing homes: an uncontrolled before and after study

    PubMed Central

    van Welie, Steven; Wijma, Linda; Beerden, Tim; van Doormaal, Jasperien; Taxis, Katja

    2016-01-01

    Objectives Residents of nursing homes often have difficulty swallowing (dysphagia), which complicates the administration of solid oral dosage formulations. Erroneously crushing medication is common, but few interventions have been tested to improve medication safety. Therefore, we evaluated the effect of warning symbols in combination with education on the frequency of erroneously crushing medication in nursing homes. Setting This was a prospective uncontrolled intervention study with a preintervention and postintervention measurement. The study was conducted on 18 wards (total of 200 beds) in 3 nursing homes in the North of the Netherlands. Participants We observed 36 nurses/nursing assistants (92% female; 92% nursing assistants) administering medication to 197 patients (62.9% female; mean age 81.6). Intervention The intervention consisted of a set of warning symbols printed on each patient's unit dose packaging indicating whether or not a medication could be crushed as well as education of ward staff (lectures, newsletter and poster). Primary outcome measure The relative risk (RR) of a crushing error occurring in the postintervention period compared to the preintervention period. A crushing error was defined as the crushing of a medication considered unsuitable to be crushed based on standard reference sources. Data were collected using direct (disguised) observation of nurses during drug administration. Results The crushing error rate decreased from 3.1% (21 wrongly crushed medicines out of 681 administrations) to 0.5% (3/636), RR=0.15 (95% CI 0.05 to 0.51). Likewise, there was a significant reduction using data from patients with swallowing difficulties only, 87.5% (21 errors/24 medications) to 30.0% (3/10) (RR 0.34, 95% CI 0.13 to 0.89). Medications which were erroneously crushed included enteric-coated formulations (eg, omeprazole), medication with regulated release systems (eg, Persantin; dipyridamol) and toxic substances (eg, finasteride). Conclusions

  19. The Global Emergency Observation and Warning System

    NASA Technical Reports Server (NTRS)

    Bukley, Angelia P.; Mulqueen, John A.

    1994-01-01

    Based on an extensive characterization of natural hazards, and an evaluation of their impacts on humanity, a set of functional technical requirements for a global warning and relief system was developed. Since no technological breakthroughs are required to implement a global system capable of performing the functions required to provide sufficient information for prevention, preparedness, warning, and relief from natural disaster effects, a system is proposed which would combine the elements of remote sensing, data processing, information distribution, and communications support on a global scale for disaster mitigation.

  20. Correlation between phosphatidylinositol labeling and contraction in rabbit aorta: effect of alpha-1 adrenergic activation

    SciTech Connect

    Villalobos-Molina, R.; Uc, M.; Hong, E.; Garcia-Sainz, J.A.

    1982-07-01

    Activation of rabbit aortic strips with alpha adrenergic agonists increased the labeling (with (/sup 32/P)Pi) of phosphatidylinositol (PI) and phosphatidic acid and contracted the vascular preparations in dose-related fashion. Epinephrine, norepinephrine and methoxamine produced maximal effects, whereas clonidine behaved as partial agonist and B-HT 933 (2-amino-6-ethyl-4,5,7,8-tetrahydro-6H-oxazole-(5,4-d) azepin dihydrochloride) was almost without activity in the two experimental models used. Phenylephrine was a full agonist in producing contraction, but failed to elicit the maximal increase in PI labeling. The EC50 values to produce contraction of aortic strips were lower for all agonists than those required to increase the incorporation of radioactive phosphate into PI, but there was a good correlation between the two sets of data. The increased PI labeling and contraction of aortic strips induced by epinephrine were antagonized by prazosin and yohimbine in dose-related fashion, but the first alpha blocker was about three orders of magnitude more potent than the second in antagonizing the two effects. The present results indicate that both stimulation of PI labeling and contraction are mediated through activation of alpha-1 adrenoceptors in rabbit aorta.

  1. Directing gaze: the effect of disclaimer labels on women's visual attention to fashion magazine advertisements.

    PubMed

    Bury, Belinda; Tiggemann, Marika; Slater, Amy

    2014-09-01

    In an effort to combat the known negative effects of exposure to unrealistic thin ideal images, there is increasing worldwide pressure on fashion, media and advertising industries to disclose when images have been digitally altered. The current study used eye tracking technology to investigate experimentally how digital alteration disclaimer labels impact women's visual attention to fashion magazine advertisements. Participants were 60 female undergraduate students who viewed four thin ideal advertisements with either no disclaimer, a generic disclaimer, or a specific more detailed disclaimer. It was established that women did attend to the disclaimers. The nature of the disclaimer had no effect on time spent looking at particular body parts, but did affect the direction of gaze following reading of the disclaimer. This latter effect was found to be greater for women high on trait appearance comparison. Further research is paramount in guiding effective policy around the use of disclaimer labels. PMID:24997284

  2. The Collaborative Encoding Deficit is Attenuated with Specific Warnings

    PubMed Central

    Barber, Sarah J.; Rajaram, Suparna; Paneerselvam, Bavani

    2012-01-01

    Individuals learning together do so less effectively than individuals learning alone, an effect known as the collaborative encoding deficit (Barber, Rajaram, & Aron, 2010). In the present studies we examined whether providing participants with a warning about the collaborative encoding deficit would increase their encoding task performance, and reduce subsequent memory deficits. Across two experiments, specific warnings were beneficial for memory. Collaborating participants who were told about the collaborative encoding deficit, and who received suggestions for how to complete the encoding task, had superior memory than participants who received no warning. This benefit was not due to qualitative changes in encoding task performance, was unrelated to the type of collaboration utilized, was absent when a more general warning was utilized, and was unrelated to self-reported task motivation. Rather, specific warnings appear to protect against the collaborative encoding deficit by increasing time spent on, and attention directed to, the encoding task. PMID:23296389

  3. 21 CFR 801.405 - Labeling of articles intended for lay use in the repairing and/or refitting of dentures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... reliners, pads, and cushions; and (3) Includes a conspicuous warning statement to the effect: (i) For... Administration of their concern regarding the safety of denture reliners, repair kits, pads, cushions, and other..., Drug, and Cosmetic Act, unless the labeling: (1)(i) Limits directions for use for denture repair...

  4. 21 CFR 801.405 - Labeling of articles intended for lay use in the repairing and/or refitting of dentures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... reliners, pads, and cushions; and (3) Includes a conspicuous warning statement to the effect: (i) For... Administration of their concern regarding the safety of denture reliners, repair kits, pads, cushions, and other..., Drug, and Cosmetic Act, unless the labeling: (1)(i) Limits directions for use for denture repair...

  5. Brief report: Labelling effects on the perceived deleterious consequences of pop music listening.

    PubMed

    North, Adrian C; Hargreaves, David J

    2005-06-01

    Several correlational studies have supported the claim of conservative protestors that there exists a positive relationship between listening to pop music and adolescent problem behaviours. However, research on the so-called 'prestige effects' has shown that experimental participants' responses to music can be mediated by manipulations of prior information concerning that music. This study investigated whether perceptions of deleterious effects of pop songs on listeners may be attributable to prior labelling of those stimuli as 'problem music'. Eighty undergraduates were played songs that they were told were either suicide-inducing or life-affirming. Subsequent ratings of the songs indicated that those presented as 'suicide-inducing' were perceived as such, whereas presentation of the same songs in a 'life-affirming' frame led to the perception of them as such. These findings indicate that censorship and the subsequent labelling of certain songs as 'problematic' might itself cause these songs to have deleterious effects on listeners.

  6. Brief report: Labelling effects on the perceived deleterious consequences of pop music listening.

    PubMed

    North, Adrian C; Hargreaves, David J

    2005-06-01

    Several correlational studies have supported the claim of conservative protestors that there exists a positive relationship between listening to pop music and adolescent problem behaviours. However, research on the so-called 'prestige effects' has shown that experimental participants' responses to music can be mediated by manipulations of prior information concerning that music. This study investigated whether perceptions of deleterious effects of pop songs on listeners may be attributable to prior labelling of those stimuli as 'problem music'. Eighty undergraduates were played songs that they were told were either suicide-inducing or life-affirming. Subsequent ratings of the songs indicated that those presented as 'suicide-inducing' were perceived as such, whereas presentation of the same songs in a 'life-affirming' frame led to the perception of them as such. These findings indicate that censorship and the subsequent labelling of certain songs as 'problematic' might itself cause these songs to have deleterious effects on listeners. PMID:15925693

  7. Evaluating Warning Sound Urgency with Reaction Times

    ERIC Educational Resources Information Center

    Suied, Clara; Susini, Patrick; McAdams, Stephen

    2008-01-01

    It is well-established that subjective judgments of perceived urgency of alarm sounds can be affected by acoustic parameters. In this study, the authors investigated an objective measurement, the reaction time (RT), to test the effectiveness of temporal parameters of sounds in the context of warning sounds. Three experiments were performed using a…

  8. Crowdsourced earthquake early warning.

    PubMed

    Minson, Sarah E; Brooks, Benjamin A; Glennie, Craig L; Murray, Jessica R; Langbein, John O; Owen, Susan E; Heaton, Thomas H; Iannucci, Robert A; Hauser, Darren L

    2015-04-01

    Earthquake early warning (EEW) can reduce harm to people and infrastructure from earthquakes and tsunamis, but it has not been implemented in most high earthquake-risk regions because of prohibitive cost. Common consumer devices such as smartphones contain low-cost versions of the sensors used in EEW. Although less accurate than scientific-grade instruments, these sensors are globally ubiquitous. Through controlled tests of consumer devices, simulation of an M w (moment magnitude) 7 earthquake on California's Hayward fault, and real data from the M w 9 Tohoku-oki earthquake, we demonstrate that EEW could be achieved via crowdsourcing. PMID:26601167

  9. Crowdsourced earthquake early warning

    PubMed Central

    Minson, Sarah E.; Brooks, Benjamin A.; Glennie, Craig L.; Murray, Jessica R.; Langbein, John O.; Owen, Susan E.; Heaton, Thomas H.; Iannucci, Robert A.; Hauser, Darren L.

    2015-01-01

    Earthquake early warning (EEW) can reduce harm to people and infrastructure from earthquakes and tsunamis, but it has not been implemented in most high earthquake-risk regions because of prohibitive cost. Common consumer devices such as smartphones contain low-cost versions of the sensors used in EEW. Although less accurate than scientific-grade instruments, these sensors are globally ubiquitous. Through controlled tests of consumer devices, simulation of an Mw (moment magnitude) 7 earthquake on California’s Hayward fault, and real data from the Mw 9 Tohoku-oki earthquake, we demonstrate that EEW could be achieved via crowdsourcing. PMID:26601167

  10. Crowdsourced earthquake early warning.

    PubMed

    Minson, Sarah E; Brooks, Benjamin A; Glennie, Craig L; Murray, Jessica R; Langbein, John O; Owen, Susan E; Heaton, Thomas H; Iannucci, Robert A; Hauser, Darren L

    2015-04-01

    Earthquake early warning (EEW) can reduce harm to people and infrastructure from earthquakes and tsunamis, but it has not been implemented in most high earthquake-risk regions because of prohibitive cost. Common consumer devices such as smartphones contain low-cost versions of the sensors used in EEW. Although less accurate than scientific-grade instruments, these sensors are globally ubiquitous. Through controlled tests of consumer devices, simulation of an M w (moment magnitude) 7 earthquake on California's Hayward fault, and real data from the M w 9 Tohoku-oki earthquake, we demonstrate that EEW could be achieved via crowdsourcing.

  11. The effect of drugs on the labeling of blood elements with technetium-99m.

    PubMed

    Braga, A C; Oliveira, M B; Feliciano, G D; Reiniger, I W; Oliveira, J F; Silva, C R; Bernardo-Filho, M

    2000-07-01

    The influence of drugs on the labeling of red blood cells and plasma proteins with 99mTc has been reported. Any drug, which alters the labeling of the tracer, could be expected to modify the disposition of the radiopharmaceuticals. Red blood cells (RBC) labeled with technetium-99m (99mTc) are used for several evaluations in nuclear medicine. We have evaluated the effect of Thuya occidentalis, Peumus boldus and Nicotiana tabacum (tobacco) extracts on the labeling of RBC and plasma and cellular proteins with 99mTc. Blood was incubated with the drugs. Stannous chloride (SnCl2) solutions and 99mTc were added. Plasma (P) and blood cells (BC) were separated. The percentage of radioactivity (%ATI) bound to P and BC was determined. The %ATI on the plasma and cellular proteins was also evaluated by precipitation of P and BC samples with trichloroacetic acid (TCA) and isolation of soluble (SF) and insoluble (IF) fractions. The analysis of the results shows that there is a decrease in %ATI (from 97.64 to 75.89 percent) in BC with Thuya occidentalis extract. The labeling of RBC and plasma proteins can be decreased in presence of tobacco. This can be due either a direct or indirect effect (reactive oxygen species) of tobacco. The analysis of radioactivity in samples of P and BC isolated from samples of whole blood treated with Peumus boldus showed a rapid uptake of the radioactivity by blood cells in the presence of the Peumus boldus, whereas there was a slight decrease in the amount of 99mTc radioactivity in the TCA-insoluble fraction of plasma. This study shows that extracts of some medicinal plants can affect the radiolabeling of red blood cells with 99mTc using an in vitro technique. PMID:10903389

  12. Assessment of a severe-weather warning system and disaster preparedness, Calhoun County, Alabama, 1994.

    PubMed Central

    Liu, S; Quenemoen, L E; Malilay, J; Noji, E; Sinks, T; Mendlein, J

    1996-01-01

    Tornado preparedness warning system effectiveness, and shelter-seeking behavior were examined in two Alabama areas after tornado warnings. In the area without sirens, only 28.9% of 194 respondents heard a tornado warning of these, 73.2% first received the warning from radios or television. In the area with sirens, 88.1% of 193 respondents heard a warning, and 61.8% first received the warning from a siren. Knowledge of warnings, access to shelter, and education were key predictors for seeking shelter. Our findings indicate that installing sirens, providing access to shelter, and teaching appropriate responses to warnings are important elements of an effective disaster prevention system. PMID:8561251

  13. A SDMS Model: Early Warning Coordination Centres

    NASA Astrophysics Data System (ADS)

    Santos-Reyes, Jaime

    2010-05-01

    Following the tsunami disaster in 2004, the General Secretary of the United Nations (UN) Kofi Annan called for a global early warning system for all hazards and for all communities. He also requested the ISDR (International Strategy fort Disaster Reduction) and its UN partners to conduct a global survey of capacities, gaps and opportunities in relation to early warning systems. The produced report, "Global survey of Early Warning Systems", concluded that there are many gaps and shortcomings and that much progress has been made on early warning systems and great capabilities are available around the world. However, it may be argued that an early warning system (EWS) may not be enough to prevent fatalities due to a natural hazard; i.e., it should be seen as part of a ‘wider' or total system. Furthermore, an EWS may work very well when assessed individually but it is not clear whether it will contribute to accomplish the purpose of the ‘total disaster management system'; i.e., to prevent fatalities. For instance, a regional EWS may only work if it is well co-ordinated with the local warning and emergency response systems that ensure that the warning is received, communicated and acted upon by the potentially affected communities. It may be argued that without these local measures being in place, a regional EWS will have little impact in saving lives. Researchers argued that unless people are warned in remote areas, the technology is useless; for instance McGuire [5] argues that: "I have no doubt that the technical element of the warning system will work very well,"…"But there has to be an effective and efficient communications cascade from the warning centre to the fisherman on the beach and his family and the bar owners." Similarly, McFadden [6] states that: "There's no point in spending all the money on a fancy monitoring and a fancy analysis system unless we can make sure the infrastructure for the broadcast system is there,"… "That's going to require a lot

  14. 49 CFR 234.259 - Warning time.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Warning time. 234.259 Section 234.259..., Inspection, and Testing Inspections and Tests § 234.259 Warning time. Each crossing warning system shall be tested for the prescribed warning time at least once every 12 months and when the warning system...

  15. 21 CFR 801.63 - Medical devices; warning statements for devices containing or manufactured with...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Medical devices; warning statements for devices... Section 801.63 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES LABELING Labeling Requirements for Over-the-Counter Devices § 801.63...

  16. 21 CFR 201.315 - Over-the-counter drugs for minor sore throats; suggested warning.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Over-the-counter drugs for minor sore throats... AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.315 Over-the-counter drugs for minor sore throats; suggested warning. The Food...

  17. 21 CFR 201.315 - Over-the-counter drugs for minor sore throats; suggested warning.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Over-the-counter drugs for minor sore throats... AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.315 Over-the-counter drugs for minor sore throats; suggested warning. The Food...

  18. Longer Term Impact of Cigarette Package Warnings in Australia Compared with the United Kingdom and Canada

    ERIC Educational Resources Information Center

    Li, Lin; Borland, Ron; Yong, Hua; Cummings, Kenneth M.; Thrasher, James F.; Hitchman, Sara C.; Fong, Geoffrey T.; Hammond, David; Bansal-Travers, Maansi

    2015-01-01

    This study examines the effects of different cigarette package warnings in Australia, Canada and the United Kingdom up to 5 years post-implementation. The data came from the International Tobacco Control Surveys. Measures included salience of warnings, cognitive responses, forgoing cigarettes and avoiding warnings. Although salience of the UK…

  19. 30 CFR 75.1103-4 - Automatic fire sensor and warning device systems; installation; minimum requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Automatic fire sensor and warning device...-UNDERGROUND COAL MINES Fire Protection § 75.1103-4 Automatic fire sensor and warning device systems; installation; minimum requirements. (a) Effective December 31, 2009, automatic fire sensor and warning...

  20. Effect of antiarrhythmic drugs on In-111-labeled leukocytes: chemotaxis and adherence to nylon wool

    SciTech Connect

    Thakur, M.L.; Walsh, L.J.; Zaret, B.L.; Gottschalk, A.

    1982-02-01

    The influence of lidocaine (L) and procainamide (P) on the chemotactic ability and adherence to nylon wool of In-111-labeled human polymorphonuclear leukocytes (PMNs) was investigated. At the normal therapeutic levels of L (0.022 mM whole blood) or P (0.03 mM whole blood) no change in PMN function was observed. However, at and above five times the aforementioned blood levels of L, significant reduction in the chemotactic ability of PMNs was noted (p less than 0.005). The adverse effects of In-111 radiation appeared insignificant at all L or P concentrations during the 3-hr observation period. The labeled PMNs were resistant to the toxic effects of a higher concentration of P than that of L, and the reduction in PMN chemotaxis and adherence to nylon wool was not apparent until the P concentration reached 1.5 mM.

  1. The Effects of Branching and Deuterium Labeling on Polymer Blend Miscibility

    NASA Astrophysics Data System (ADS)

    Defelice, Jeffrey; Higgins, Julia; Lipson, Jane

    Local structural or chemical changes made to one component of a polymer blend can have a significant impact on miscibility. In this talk we will focus on several blends involving linear and 4-arm star polystyrene (PS), both hydrogenous and deuterated, and poly(vinylmethylether) (PVME). We consider the effect of the structural change on the miscibility of PS/PVME, then turn to the added effect of deuterium labeling, both on this blend and for isotopic PS mixtures. Using our Locally Correlated Lattice (LCL) model we are able to identify trends in the physical properties of pure components, such as: free volume, thermal expansion coefficient, and cohesive energy density. We find that branching and labeling, both independently and cumulatively, affect pure component properties. Our ability to correlate structural and chemical changes with trends in physical properties leads to predictions about the compatibility of pure components, and thus their blend miscibility. The authors gratefully acknowledge support from NSF DMR-1403757 and GAANN.

  2. The effect of food preparation on the bioavailability of carotenoids from carrots using intrinsic labelling.

    PubMed

    Ghavami, Abdollah; Coward, W Andy; Bluck, Les J C

    2012-05-01

    A strategy to reduce the incidence of vitamin A deficiency is to improve precursor bioavailability from meals. Since vitamin A precursors are fat-soluble, we noted that carotenoids are more easily absorbed from food if prepared in such a way that the food matrix containing provitamin A (β-carotene) is sufficiently fat rich. To quantify this effect, we have developed a stable isotope methodology. By regular watering with 2H-labelled water, we were able to produce several kg of intrinsically labelled carrots, with carotenoids labelled to 0.63 % excess 2H. These were divided into 100 g portions and fed to a small group of healthy subjects both raw and stir-fried. To normalise for inter-individual variation in absorption and subsequent metabolism, small quantities of extrinsically 13C-labelled β-carotene and 2H-labelled retinol acetate were also incorporated into the meal. After ingestion of the carrots, blood lipids were monitored for a period of 3 d in order to determine the kinetics of β-carotene and retinol. From kinetic data, it was estimated that the bioavailability of carrot-derived β-carotene compared with pure β-carotene was about 11 % for raw carrots, but 75 % when the carrots were stir-fried. Conversely, there was a slight reduction in the bioconversion to retinol from β-carotene when the latter was derived from the stir-fried meal compared with that from raw carrots. When these two factors are combined, the yield of retinol from the carotene in carrots was found to be enhanced by a factor of 6.5 by stir-frying.

  3. 16 CFR 1213.5 - Marking and labeling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... STANDARD FOR ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.5 Marking and labeling. (a) There shall be a permanent label or marking on each bed stating the name and address (city, state, and zip code) of the... following warning label shall be permanently attached to the inside of an upper bunk bed end structure in...

  4. 27 CFR 20.136 - Labeling regulations of other agencies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... containing strong chemicals should refer to 16 CFR Chapter II for warning label requirements. (c) Federal... regulations to administer the Federal Hazardous Substances Act. The regulations in 16 CFR Chapter II require... Fair Packaging and Labeling Act. The regulations in 16 CFR Chapter I affect packaging and labeling...

  5. Linking the evolution and form of warning coloration in nature

    PubMed Central

    Stevens, Martin; Ruxton, Graeme D.

    2012-01-01

    Many animals are toxic or unpalatable and signal this to predators with warning signals (aposematism). Aposematic appearance has long been a classical system to study predator–prey interactions, communication and signalling, and animal behaviour and learning. The area has received considerable empirical and theoretical investigation. However, most research has centred on understanding the initial evolution of aposematism, despite the fact that these studies often tell us little about the form and diversity of real warning signals in nature. In contrast, less attention has been given to the mechanistic basis of aposematic markings; that is, ‘what makes an effective warning signal?’, and the efficacy of warning signals has been neglected. Furthermore, unlike other areas of adaptive coloration research (such as camouflage and mate choice), studies of warning coloration have often been slow to address predator vision and psychology. Here, we review the current understanding of warning signal form, with an aim to comprehend the diversity of warning signals in nature. We present hypotheses and suggestions for future work regarding our current understanding of several inter-related questions covering the form of warning signals and their relationship with predator vision, learning, and links to broader issues in evolutionary ecology such as mate choice and speciation. PMID:22113031

  6. Linking the evolution and form of warning coloration in nature.

    PubMed

    Stevens, Martin; Ruxton, Graeme D

    2012-02-01

    Many animals are toxic or unpalatable and signal this to predators with warning signals (aposematism). Aposematic appearance has long been a classical system to study predator-prey interactions, communication and signalling, and animal behaviour and learning. The area has received considerable empirical and theoretical investigation. However, most research has centred on understanding the initial evolution of aposematism, despite the fact that these studies often tell us little about the form and diversity of real warning signals in nature. In contrast, less attention has been given to the mechanistic basis of aposematic markings; that is, 'what makes an effective warning signal?', and the efficacy of warning signals has been neglected. Furthermore, unlike other areas of adaptive coloration research (such as camouflage and mate choice), studies of warning coloration have often been slow to address predator vision and psychology. Here, we review the current understanding of warning signal form, with an aim to comprehend the diversity of warning signals in nature. We present hypotheses and suggestions for future work regarding our current understanding of several inter-related questions covering the form of warning signals and their relationship with predator vision, learning, and links to broader issues in evolutionary ecology such as mate choice and speciation.

  7. Pictorial cigarette pack warnings: a meta-analysis of experimental studies

    PubMed Central

    Noar, Seth M; Hall, Marissa G; Francis, Diane B; Ribisl, Kurt M; Pepper, Jessica K; Brewer, Noel T

    2016-01-01

    Objective To inform international research and policy, we conducted a meta-analysis of the experimental literature on pictorial cigarette pack warnings. Data sources We systematically searched 7 computerised databases in April 2013 using several search terms. We also searched reference lists of relevant articles. Study selection We included studies that used an experimental protocol to test cigarette pack warnings and reported data on both pictorial and text-only conditions. 37 studies with data on 48 independent samples (N=33 613) met criteria. Data extraction and synthesis Two independent coders coded all study characteristics. Effect sizes were computed from data extracted from study reports and were combined using random effects meta-analytic procedures. Results Pictorial warnings were more effective than text-only warnings for 12 of 17 effectiveness outcomes (all p<0.05). Relative to text-only warnings, pictorial warnings (1) attracted and held attention better; (2) garnered stronger cognitive and emotional reactions; (3) elicited more negative pack attitudes and negative smoking attitudes and (4) more effectively increased intentions to not start smoking and to quit smoking. Participants also perceived pictorial warnings as being more effective than text-only warnings across all 8 perceived effectiveness outcomes. Conclusions The evidence from this international body of literature supports pictorial cigarette pack warnings as more effective than text-only warnings. Gaps in the literature include a lack of assessment of smoking behaviour and a dearth of theory-based research on how warnings exert their effects. PMID:25948713

  8. Tobacco Health Warning Messages on Plain Cigarette Packs and in Television Campaigns: A Qualitative Study with Australian Socioeconomically Disadvantaged Smokers

    ERIC Educational Resources Information Center

    Guillaumier, Ashleigh; Bonevski, Billie; Paul, Christine

    2015-01-01

    Television advertisements, packaging regulations and health warning labels (HWLs) are designed to communicate anti-smoking messages to large number of smokers. However, only a few studies have examined how high smoking prevalence groups respond to these warnings. This study explored how socioeconomically disadvantaged smokers engage with health…

  9. Comparison of two warning concepts of an intelligent Curve Warning system for motorcyclists in a simulator study.

    PubMed

    Huth, Véronique; Biral, Francesco; Martín, Oscar; Lot, Roberto

    2012-01-01

    Curve crashes are a particular matter of concern regarding motorcycle riding safety. For this reason, an intelligent Curve Warning system has been designed that gives the riders support when negotiating a curve. The system has been tested in a simulator study carried out with 20 test riders. The subjects performed three rides: one without the system (baseline) and two experimental rides using a version of the Curve Warning system, one providing the warnings by a force feedback throttle and one by a haptic glove. The effects of the two system versions were evaluated both in terms of the simulated riding performance and the subjective assessment by the riders. A descriptive analysis of the riders' reactions to the warnings shows that the warnings provided by both system versions provoke an earlier and stronger adaptation of the motorcycle dynamics to the curve than when the riders do not use the system. Riding with the Curve Warning system with the haptic glove furthermore leads to a reduction of critical curve events. The riders' subjective workload level was not affected by the system use, whereas the Curve Warning system with the force feedback throttle required an increased attention. The comparison of the riders' opinions about the system reveals a preference of the Curve Warning system with the haptic glove. The better acceptance of this system version suggests a higher potential in the enhancement of riding safety.

  10. Quantifying Age-Related Differences in Information Processing Behaviors When Viewing Prescription Drug Labels

    PubMed Central

    Sundar, Raghav Prashant; Becker, Mark W.; Bello, Nora M.; Bix, Laura

    2012-01-01

    Adverse drug events (ADEs) are a significant problem in health care. While effective warnings have the potential to reduce the prevalence of ADEs, little is known about how patients access and use prescription labeling. We investigated the effectiveness of prescription warning labels (PWLs, small, colorful stickers applied at the pharmacy) in conveying warning information to two groups of patients (young adults and those 50+). We evaluated the early stages of information processing by tracking eye movements while participants interacted with prescription vials that had PWLs affixed to them. We later tested participants’ recognition memory for the PWLs. During viewing, participants often failed to attend to the PWLs; this effect was more pronounced for older than younger participants. Older participants also performed worse on the subsequent memory test. However, when memory performance was conditionalized on whether or not the participant had fixated the PWL, these age-related differences in memory were no longer significant, suggesting that the difference in memory performance between groups was attributable to differences in attention rather than differences in memory encoding or recall. This is important because older adults are recognized to be at greater risk for ADEs. These data provide a compelling case that understanding consumers’ attentive behavior is crucial to developing an effective labeling standard for prescription drugs. PMID:22719955

  11. The Effect of Peptide Identification Search Algorithms on MS2-Based Label-Free Protein Quantification

    PubMed Central

    Degroeve, Sven; Staes, An; De Bock, Pieter-Jan

    2012-01-01

    Abstract Several approaches exist for the quantification of proteins in complex samples processed by liquid chromatography-mass spectrometry followed by fragmentation analysis (MS2). One of these approaches is label-free MS2-based quantification, which takes advantage of the information computed from MS2 spectrum observations to estimate the abundance of a protein in a sample. As a first step in this approach, fragmentation spectra are typically matched to the peptides that generated them by a search algorithm. Because different search algorithms identify overlapping but non-identical sets of peptides, here we investigate whether these differences in peptide identification have an impact on the quantification of the proteins in the sample. We therefore evaluated the effect of using different search algorithms by examining the reproducibility of protein quantification in technical repeat measurements of the same sample. From our results, it is clear that a search engine effect does exist for MS2-based label-free protein quantification methods. As a general conclusion, it is recommended to address the overall possibility of search engine-induced bias in the protein quantification results of label-free MS2-based methods by performing the analysis with two or more distinct search engines. PMID:22804230

  12. 27 CFR 16.21 - Mandatory label information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS ALCOHOLIC BEVERAGE HEALTH WARNING STATEMENT Health Warning Statement Requirements for Alcoholic Beverages § 16.21 Mandatory label information. There shall be stated on... not drink alcoholic beverages during pregnancy because of the risk of birth defects. (2)...

  13. 27 CFR 16.21 - Mandatory label information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL ALCOHOLIC BEVERAGE HEALTH WARNING STATEMENT Health Warning Statement Requirements for Alcoholic Beverages § 16.21 Mandatory label information. There shall be stated on... not drink alcoholic beverages during pregnancy because of the risk of birth defects. (2)...

  14. 27 CFR 16.21 - Mandatory label information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL ALCOHOLIC BEVERAGE HEALTH WARNING STATEMENT Health Warning Statement Requirements for Alcoholic Beverages § 16.21 Mandatory label information. There shall be stated on... not drink alcoholic beverages during pregnancy because of the risk of birth defects. (2)...

  15. 27 CFR 16.21 - Mandatory label information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS ALCOHOLIC BEVERAGE HEALTH WARNING STATEMENT Health Warning Statement Requirements for Alcoholic Beverages § 16.21 Mandatory label information. There shall be stated on... not drink alcoholic beverages during pregnancy because of the risk of birth defects. (2)...

  16. 27 CFR 16.21 - Mandatory label information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS ALCOHOLIC BEVERAGE HEALTH WARNING STATEMENT Health Warning Statement Requirements for Alcoholic Beverages § 16.21 Mandatory label information. There shall be stated on... not drink alcoholic beverages during pregnancy because of the risk of birth defects. (2)...

  17. Stronger pack warnings predict quitting more than weaker ones: finding from the ITC Malaysia and Thailand surveys

    PubMed Central

    2013-01-01

    Background We examined the impact of cigarette pack warning labels on interest in quitting and subsequent quit attempts among adult smokers in Malaysia and Thailand. Methods Two overlapping cohorts of adults who reported smoking factory- made cigarettes from Malaysia and Thailand were interviewed face-to-face (3189 were surveyed at baseline and 1781 re-contacted at Wave 2; 2361 current smokers were surveyed at Wave 2 and 1586 re-contacted at Wave 3). In Thailand at baseline, large text only warnings were assessed, while at Wave 2 new large graphic warnings were assessed. In Malaysia, during both waves small text only warnings were in effect. Reactions were used to predict interest in quitting, and to predict making quit attempts over the following inter-wave interval. Results Multivariate predictors of “interest in quitting” were comparable across countries, but predictors of quit attempts varied. In both countries, cognitive reactions to warnings (adjusted ORs; 1.57 & 1.69 for Malaysia at wave 1 and wave 2 respectively and 1.29 & 1.19 for Thailand at wave 1 and wave 2 respectively), forgoing a cigarette (except Wave 2 in Malaysia) (adjusted ORs; 1.77 for Malaysia at wave 1 and 1.54 & 2.32 for Thailand at wave 1 and wave 2 respectively), and baseline knowledge (except wave 2 in both countries) (adjusted ORs; 1.71 & 1.51 for Malaysia and Thailand respectively) were positively associated with interest in quitting at that wave. In Thailand only, “cognitive reactions to warnings” (adjusted ORs; 1.12 & 1.23 at wave 1 and wave 2 respectively), “forgoing a cigarette” (adjusted OR = 1.55 at wave 2 only) and “an interest in quitting” (adjusted ORs; 1.61 & 2.85 at wave 1 and wave 2 respectively) were positively associated with quit attempts over the following inter-wave interval. Salience was negatively associated with subsequent quit attempts in both Malaysia and Thailand, but at Wave 2 only (adjusted ORs; 0.89 & 0.88 for Malaysia and Thailand

  18. Car Gestures - Advisory warning using additional steering wheel angles.

    PubMed

    Maag, Christian; Schneider, Norbert; Lübbeke, Thomas; Weisswange, Thomas H; Goerick, Christian

    2015-10-01

    Advisory warning systems (AWS) notify the driver about upcoming hazards. This is in contrast to the majority of currently deployed advanced driver assistance systems (ADAS) that manage emergency situations. The target of this study is to investigate the effectiveness, acceptance, and controllability of a specific kind of AWS that uses the haptic information channel for warning the driver. This could be beneficial, as alternatives for using the visual modality can help to reduce the risk of visual overload. The driving simulator study (N=24) compared an AWS based on additional steering wheel angle control (Car Gestures) with a visual warning presented in a simulated head-up display (HUD). Both types of warning were activated 3.5s before the hazard object was reached. An additional condition of unassisted driving completed the experimental design. The subjects encountered potential hazards in a variety of urban situations (e.g. a pedestrian standing on the curbs). For the investigated situations, subjective ratings show that a majority of drivers prefer visual warnings over haptic information via gestures. An analysis of driving behavior indicates that both warning approaches guide the vehicle away from the potential hazard. Whereas gestures lead to a faster lateral driving reaction (compared to HUD warnings), the visual warnings result in a greater safety benefit (measured by the minimum distance to the hazard object). A controllability study with gestures in the wrong direction (i.e. leading toward the hazard object) shows that drivers are able to cope with wrong haptic warnings and safety is not reduced compared to unassisted driving as well as compared to (correct) haptic gestures and visual warnings.

  19. Tsunami warnings: Understanding in Hawai'i

    USGS Publications Warehouse

    Gregg, Chris E.; Houghton, B.F.; Paton, Douglas; Johnston, David M.; Swanson, D.A.; Yanagi, B.S.

    2007-01-01

    The devastating southeast Asian tsunami of December 26, 2004 has brought home the destructive consequences of coastal hazards in an absence of effective warning systems. Since the 1946 tsunami that destroyed much of Hilo, Hawai'i, a network of pole mounted sirens has been used to provide an early public alert of future tsunamis. However, studies in the 1960s showed that understanding of the meaning of siren soundings was very low and that ambiguity in understanding had contributed to fatalities in the 1960 tsunami that again destroyed much of Hilo. The Hawaiian public has since been exposed to monthly tests of the sirens for more than 25 years and descriptions of the system have been widely published in telephone books for at least 45 years. However, currently there remains some uncertainty in the level of public understanding of the sirens and their implications for behavioral response. Here, we show from recent surveys of Hawai'i residents that awareness of the siren tests and test frequency is high, but these factors do not equate with increased understanding of the meaning of the siren, which remains disturbingly low (13%). Furthermore, the length of time people have lived in Hawai'i is not correlated systematically with understanding of the meaning of the sirens. An additional issue is that warning times for tsunamis gene rated locally in Hawai'i will be of the order of minutes to tens of minutes and limit the immediate utility of the sirens. Natural warning signs of such tsunamis may provide the earliest warning to residents. Analysis of a survey subgroup from Hilo suggests that awareness of natural signs is only moderate, and a majority may expect notification via alerts provided by official sources. We conclude that a major change is needed in tsunami education, even in Hawai'i, to increase public understanding of, and effective response to, both future official alerts and natural warning signs of future tsunamis. ?? Springer 2006.

  20. Rooting out institutional corruption to manage inappropriate off-label drug use.

    PubMed

    Rodwin, Marc A

    2013-01-01

    Prescribing drugs for uses that the FDA has not approved - off-label drug use - can sometimes be justified but is typically not supported by substantial evidence of effectiveness. At the root of inappropriate off-label drug use lie perverse incentives for pharmaceutical firms and flawed oversight of prescribing physicians. Typical reform proposals such as increased sanctions for manufacturers might reduce the incidence of unjustified off-label use, but they do not remove the source of the problem. Public policy should address the cause and control the practice. To manage inappropriate off-label drug use, off-label prescriptions must be tracked in order to monitor the risks and benefits and the manufacturers' conduct. Even more important, reimbursement rules should be changed so that manufacturers cannot profit from off-label sales. When off-label sales pass a critical threshold, manufacturers should also be required to pay for independent testing of the safety and effectiveness of off-label drug uses and for the FDA to review the evidence. Manufacturers should also finance, under FDA supervision, programs designed to warn physicians and the public about the risks of off-label drug use. PMID:24088156

  1. Rooting out institutional corruption to manage inappropriate off-label drug use.

    PubMed

    Rodwin, Marc A

    2013-01-01

    Prescribing drugs for uses that the FDA has not approved - off-label drug use - can sometimes be justified but is typically not supported by substantial evidence of effectiveness. At the root of inappropriate off-label drug use lie perverse incentives for pharmaceutical firms and flawed oversight of prescribing physicians. Typical reform proposals such as increased sanctions for manufacturers might reduce the incidence of unjustified off-label use, but they do not remove the source of the problem. Public policy should address the cause and control the practice. To manage inappropriate off-label drug use, off-label prescriptions must be tracked in order to monitor the risks and benefits and the manufacturers' conduct. Even more important, reimbursement rules should be changed so that manufacturers cannot profit from off-label sales. When off-label sales pass a critical threshold, manufacturers should also be required to pay for independent testing of the safety and effectiveness of off-label drug uses and for the FDA to review the evidence. Manufacturers should also finance, under FDA supervision, programs designed to warn physicians and the public about the risks of off-label drug use.

  2. [WHO Framework Convention on Tobacco Control (FCTC) Article 11: packaging and labelling of tobacco products].

    PubMed

    Bekki, Kanae; Inaba, Yohei; Kunugita, Naoki

    2015-01-01

    The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) requires member countries to implement measures aimed at reducing the demand for tobacco products. FCTC article 11 describes the important forms of health communication and packaging regulations. And this article recommends on large pictorial health warnings and encourages more effective forms of disclosure on constituents and emissions. Furthermore, article 11 recognizes the importance of the package as a promotional vehicle for tobacco companies and requires the removal of potentially misleading packaging information, including the terms "light" and "mild." The Conference of the Parties (COP) adopted guidelines for implementation of article 11 on "Packaging and labelling of Tobacco Products". Some countries, such as Canada, the U.S.A., Australia, EU countries etc. positively promoted tobacco control by implementing countermeasures such as the graphic health warning labels and plain packages. These countermeasures showed the significant effects of decreasing smoking rate and preventing smoking initiation in young people. Furthermore, these warning labels were effective for the literally challenged. However, the Japanese government has not implemented these countermeasures, and only limited texts are shown on Japanese tobacco packaging. Therefore, Japan should emulate approaches taken by other countries, and promote the tobacco control policy in accordance with FCTC. PMID:25744790

  3. [WHO Framework Convention on Tobacco Control (FCTC) Article 11: packaging and labelling of tobacco products].

    PubMed

    Bekki, Kanae; Inaba, Yohei; Kunugita, Naoki

    2015-01-01

    The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) requires member countries to implement measures aimed at reducing the demand for tobacco products. FCTC article 11 describes the important forms of health communication and packaging regulations. And this article recommends on large pictorial health warnings and encourages more effective forms of disclosure on constituents and emissions. Furthermore, article 11 recognizes the importance of the package as a promotional vehicle for tobacco companies and requires the removal of potentially misleading packaging information, including the terms "light" and "mild." The Conference of the Parties (COP) adopted guidelines for implementation of article 11 on "Packaging and labelling of Tobacco Products". Some countries, such as Canada, the U.S.A., Australia, EU countries etc. positively promoted tobacco control by implementing countermeasures such as the graphic health warning labels and plain packages. These countermeasures showed the significant effects of decreasing smoking rate and preventing smoking initiation in young people. Furthermore, these warning labels were effective for the literally challenged. However, the Japanese government has not implemented these countermeasures, and only limited texts are shown on Japanese tobacco packaging. Therefore, Japan should emulate approaches taken by other countries, and promote the tobacco control policy in accordance with FCTC.

  4. Comparative pharmacokinetics of unlabeled and deuterium-labeled terbutaline: demonstration of a small isotope effect

    SciTech Connect

    Borgstroem, L.L.; Lindberg, C.; Joensson, S.S.; Svensson, K.

    1988-11-01

    An equimolar mixture of terbutaline and (/sup 2/H6)terbutaline was given as an oral solution to six healthy volunteers (three men and three women). Frequent blood samples were collected during a 24-h period and the plasma concentrations of unlabeled and deuterium-labeled terbutaline were measured by GC-MS. The overall geometric mean plasma concentration ratio of terbutaline to (/sup 2/H6)terbutaline (isotope ratio) was 1.04 and differed significantly from unity. The difference can be explained by a difference in lipophilicity between the analogues, affecting their absorption. No trend in isotope ratio over the experimental time was observed. For unknown reasons, the isotope ratio was higher for women (1.07) than for men (1.00). Deuterium-labeled terbutaline can be used, intravenously or orally, as an absolute reference in bioavailability studies on terbutaline. If deuterium-labeled terbutaline is given orally in a single-day relative bioavailability study, a correlation should be made for the observed isotope effect.

  5. Tsunami Warning Services for the Caribbean Region

    NASA Astrophysics Data System (ADS)

    Whitmore, P. M.; Ferris, J. C.; Weinstein, S. A.

    2007-05-01

    sensors are installed in the region: two north of PR/VI and one in the central Caribbean Sea. Together, these seismic and sea level data sets provide the TWCs with the necessary data to provide effective tsunami warning products and services for the Caribbean region.

  6. Health Warnings on Alcoholic Beverages: Perceptions of the Health Risks and Intentions towards Alcohol Consumption

    PubMed Central

    Wigg, Sophie; Stafford, Lorenzo D.

    2016-01-01

    Objectives Research has demonstrated that packaging which includes pictorial health warnings are more effective in altering smokers’ perceptions and intentions as well as changing smoking behaviours compared to text-only health warnings. However, very few studies have investigated the effectiveness of health warnings on alcoholic beverages Methods Participants (N = 60) viewed alcoholic beverages presenting one of three health warnings (No health warning, Text-only, Pictorial) and then responded to questions relating to level of fear arousal and their perceptions toward alcohol use. Results We found that pictorial health warnings were associated with significantly higher fear arousal, increased perceptions of the health risks of consuming alcohol as well as greater intentions to reduce and quit alcohol consumption compared to the control. Conclusions These novel findings suggest pictorial health warnings on alcoholic beverages may be an important way of making the public aware of the health risks of alcohol consumption. PMID:27105210

  7. Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice.

    PubMed

    Kovar, Joy L; Xu, Xinshe; Draney, Dan; Cupp, Andrea; Simpson, Melanie A; Olive, D Michael

    2011-09-15

    Bone-specific compounds have been used effectively for the detection of bone mineralization, growth, and morphological changes. These agents typically contain iminodiacetic acid groups that can form complexes with apatite and fluoresce in the visible spectrum. We exploited a subset of these chemical chelators to produce a near-infrared (NIR) optical bone marker for preclinical animal imaging. By conjugating target compounds to IRDye 800CW, we extended the effective fluorescence signal detection to the NIR region without affecting the compound's ability to function as a marker of the mineralization process. Calcein and a tetracycline derivative (BoneTag agent [BT]) bound specifically to differentiated mineralized osteoblast cultures, with the latter exhibiting 6-fold higher signal intensities. Subsequent in vivo testing demonstrated effective skeletal labeling with IRDye 800CW BT. We were able to identify a changing mineralization front in bone sections from (i) normal growing mice injected with IRDye 800CW BT 6weeks prior to the administration of IRDye 680 BT and (ii) an osteoporosis mouse model comparing cortical bone in sham-treated and ovariectomized mice. These results provide evidence that the NIR-labeled BT is effective as a general marker of skeletal features and an indicator of the bone mineralization and remodeling processes. PMID:21645491

  8. Effects of nutrition label format and product assortment on the healthfulness of food choice.

    PubMed

    Aschemann-Witzel, Jessica; Grunert, Klaus G; van Trijp, Hans C M; Bialkova, Svetlana; Raats, Monique M; Hodgkins, Charo; Wasowicz-Kirylo, Grazyna; Koenigstorfer, Joerg

    2013-12-01

    This study aims to find out whether front-of-pack nutrition label formats influence the healthfulness of consumers' food choices and important predictors of healthful choices, depending on the size of the choice set that is made available to consumers. The predictors explored were health motivation and perceived capability of making healthful choices. One thousand German and Polish consumers participated in the study that manipulated the format of nutrition labels. All labels referred to the content of calories and four negative nutrients and were presented on savoury and sweet snacks. The different formats included the percentage of guideline daily amount, colour coding schemes, and text describing low, medium and high content of each nutrient. Participants first chose from a set of 10 products and then from a set of 20 products, which was, on average, more healthful than the first choice set. The results showed that food choices were more healthful in the extended 20-product (vs. 10-product) choice set and that this effect is stronger than a random choice would produce. The formats colour coding and texts, particularly colour coding in Germany, increased the healthfulness of product choices when consumers were asked to choose a healthful product, but not when they were asked to choose according to their preferences. The formats did not influence consumers' motivation to choose healthful foods. Colour coding, however, increased consumers' perceived capability of making healthful choices. While the results revealed no consistent differences in the effects between the formats, they indicate that manipulating choice sets by including healthier options is an effective strategy to increase the healthfulness of food choices. PMID:23891558

  9. Effects of nutrition label format and product assortment on the healthfulness of food choice.

    PubMed

    Aschemann-Witzel, Jessica; Grunert, Klaus G; van Trijp, Hans C M; Bialkova, Svetlana; Raats, Monique M; Hodgkins, Charo; Wasowicz-Kirylo, Grazyna; Koenigstorfer, Joerg

    2013-12-01

    This study aims to find out whether front-of-pack nutrition label formats influence the healthfulness of consumers' food choices and important predictors of healthful choices, depending on the size of the choice set that is made available to consumers. The predictors explored were health motivation and perceived capability of making healthful choices. One thousand German and Polish consumers participated in the study that manipulated the format of nutrition labels. All labels referred to the content of calories and four negative nutrients and were presented on savoury and sweet snacks. The different formats included the percentage of guideline daily amount, colour coding schemes, and text describing low, medium and high content of each nutrient. Participants first chose from a set of 10 products and then from a set of 20 products, which was, on average, more healthful than the first choice set. The results showed that food choices were more healthful in the extended 20-product (vs. 10-product) choice set and that this effect is stronger than a random choice would produce. The formats colour coding and texts, particularly colour coding in Germany, increased the healthfulness of product choices when consumers were asked to choose a healthful product, but not when they were asked to choose according to their preferences. The formats did not influence consumers' motivation to choose healthful foods. Colour coding, however, increased consumers' perceived capability of making healthful choices. While the results revealed no consistent differences in the effects between the formats, they indicate that manipulating choice sets by including healthier options is an effective strategy to increase the healthfulness of food choices.

  10. Designing Fatigue Warning Systems: The perspective of professional drivers.

    PubMed

    Meng, Fanxing; Li, Shuling; Cao, Lingzhi; Peng, Qijia; Li, Musen; Wang, Chunhui; Zhang, Wei

    2016-03-01

    Professional drivers have been characterized as experiencing heavy fatigue resulting from long driving time in their daily work. This study aimed to explore the potential demand of Fatigue Warning Systems (FWSs) among professional drivers as a means of reducing the danger of fatigue driving and to examine their opinions regarding the design of FWSs. Six focus groups with 35 participants and a questionnaire survey with 600 respondents were conducted among Chinese truck and taxi drivers to collect qualitative and quantitative data concerning the current situation of fatigue driving and opinions regarding the design of FWSs. The results revealed that both truck and taxi drivers had a positive attitude toward FWSs, and they hoped this system could not only monitor and warn them regarding their fatigue but also somewhat relieve their fatigue before they could stop and rest. As for warning signals, participants preferred auditory warnings, as opposed to visual, vibrotactile or electric stimuli. Interestingly, it was proposed that verbal warnings involving the information regarding consequences of fatigue driving or the wishes of drivers' family members would be more effective. Additionally, different warning patterns, including graded, single and continuous warnings, were discussed in the focus group. Finally, the participants proposed many other suggestions, as well as their concerns regarding FWSs, which will provide valuable information for companies who wish to develop FWSs for professional drivers. PMID:26482894

  11. Designing Fatigue Warning Systems: The perspective of professional drivers.

    PubMed

    Meng, Fanxing; Li, Shuling; Cao, Lingzhi; Peng, Qijia; Li, Musen; Wang, Chunhui; Zhang, Wei

    2016-03-01

    Professional drivers have been characterized as experiencing heavy fatigue resulting from long driving time in their daily work. This study aimed to explore the potential demand of Fatigue Warning Systems (FWSs) among professional drivers as a means of reducing the danger of fatigue driving and to examine their opinions regarding the design of FWSs. Six focus groups with 35 participants and a questionnaire survey with 600 respondents were conducted among Chinese truck and taxi drivers to collect qualitative and quantitative data concerning the current situation of fatigue driving and opinions regarding the design of FWSs. The results revealed that both truck and taxi drivers had a positive attitude toward FWSs, and they hoped this system could not only monitor and warn them regarding their fatigue but also somewhat relieve their fatigue before they could stop and rest. As for warning signals, participants preferred auditory warnings, as opposed to visual, vibrotactile or electric stimuli. Interestingly, it was proposed that verbal warnings involving the information regarding consequences of fatigue driving or the wishes of drivers' family members would be more effective. Additionally, different warning patterns, including graded, single and continuous warnings, were discussed in the focus group. Finally, the participants proposed many other suggestions, as well as their concerns regarding FWSs, which will provide valuable information for companies who wish to develop FWSs for professional drivers.

  12. Aircraft Cabin Turbulence Warning Experiment

    NASA Technical Reports Server (NTRS)

    Bogue, Rodney K.; Larcher, Kenneth

    2006-01-01

    New turbulence prediction technology offers the potential for advance warning of impending turbulence encounters, thereby allowing necessary cabin preparation time prior to the encounter. The amount of time required for passengers and flight attendants to be securely seated (that is, seated with seat belts fastened) currently is not known. To determine secured seating-based warning times, a consortium of aircraft safety organizations have conducted an experiment involving a series of timed secured seating trials. This demonstrative experiment, conducted on October 1, 2, and 3, 2002, used a full-scale B-747 wide-body aircraft simulator, human passenger subjects, and supporting staff from six airlines. Active line-qualified flight attendants from three airlines participated in the trials. Definitive results have been obtained to provide secured seating-based warning times for the developers of turbulence warning technology

  13. 49 CFR 234.259 - Warning time.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Warning time. 234.259 Section 234.259... time. Each crossing warning system shall be tested for the prescribed warning time at least once every... devices that accurately determine actual warning time may be used in performing such tests....

  14. 49 CFR 234.259 - Warning time.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Warning time. 234.259 Section 234.259... time. Each crossing warning system shall be tested for the prescribed warning time at least once every... devices that accurately determine actual warning time may be used in performing such tests....

  15. Novel optical approaches for label-free quantification of nano-cytotoxic effects

    NASA Astrophysics Data System (ADS)

    Mues, Sarah; Antunovic, Jan; Ketelhut, Steffi; Kemper, Björn; Schnekenburger, Jürgen

    2016-03-01

    Commonly used cytotoxicity assays to determine the formation of reactive oxygen species, cell viability or cell death are often affected by applied nanomaterials, which lead to false-positive or false-negative results. Thus, novel nanomaterial toxicity testing strategies that allow for high nanomaterial doses to determine Low Effect Levels (LOEL) even of low toxic materials are of high interest. We demonstrate novel approaches to quantify cytotoxic effects with new parameter sets such as cellular refractive index, volume, density and dry mass that are obtained by digital holographic microscopy (DHM). Furthermore, we correlate results obtained from spherical (NM 300) and rod shaped (NM 302) silver nanomaterials with established cell viability and cell death assays. Moreover, in a label-free flow cytometry configuration, cell-nanoparticle-interaction-kinetics were determined by side scatter signal analysis. We demonstrate that silver spheres show a higher cytotoxicity than silver rods and found that this effect correlates with a decrease of the intracellular refractive index and a decreased temporal development of dry mass and cell covered surface area indicating reduced cell viability and increased cell death. Results from side scatter analysis suggest a dose-dependent uptake kinetics of both materials that correlates with cytotoxicity data of the established assays. Taken together, our results demonstrate DHM and flow cytometry as promising novel label-free tools for nanomaterial toxicity and cell particle interaction studies.

  16. Estimating the average treatment effects of nutritional label use using subclassification with regression adjustment.

    PubMed

    Lopez, Michael J; Gutman, Roee

    2014-11-28

    Propensity score methods are common for estimating a binary treatment effect when treatment assignment is not randomized. When exposure is measured on an ordinal scale (i.e. low-medium-high), however, propensity score inference requires extensions which have received limited attention. Estimands of possible interest with an ordinal exposure are the average treatment effects between each pair of exposure levels. Using these estimands, it is possible to determine an optimal exposure level. Traditional methods, including dichotomization of the exposure or a series of binary propensity score comparisons across exposure pairs, are generally inadequate for identification of optimal levels. We combine subclassification with regression adjustment to estimate transitive, unbiased average causal effects across an ordered exposure, and apply our method on the 2005-2006 National Health and Nutrition Examination Survey to estimate the effects of nutritional label use on body mass index.

  17. Attention mediates the effect of nutrition label information on consumers' choice. Evidence from a choice experiment involving eye-tracking.

    PubMed

    Bialkova, Svetlana; Grunert, Klaus G; Juhl, Hans Jørn; Wasowicz-Kirylo, Grazyna; Stysko-Kunkowska, Malgorzata; van Trijp, Hans C M

    2014-05-01

    In two eye-tracking studies, we explored whether and how attention to nutrition information mediates consumers' choice. Consumers had to select either the healthiest option or a product of their preference within an assortment. On each product a particular label (Choices logo, monochrome GDA label, or color-coded GDA label) communicated the product's nutrient profile. In study 1, participants had to select from 4 products differentiated, in addition to the nutrition information, by flavor (strawberry, muesli, apple, chocolate; varied within participants) and brand (local vs. global, varied between participants). Study 2 further explored brand effect within-participants, and thus only 2 flavors (strawberry, chocolate) were presented within an assortment. Actual choice made, response time and eye movements were recorded. Respondents fixated longer and more often on products with color-coded GDAs label than on products with monochrome GDAs or Choices logo. A health goal resulted in longer and more frequent fixations in comparison to a preference goal. Products with color-coded and monochrome GDAs had the highest likelihood of being chosen, and this effect was related to the attention-getting property of the label (irrespective of brand and flavor effects). The product fixated most had the highest likelihood of being chosen. These results suggest that attention mediates the effect of nutrition labels on choice.

  18. Attention mediates the effect of nutrition label information on consumers' choice. Evidence from a choice experiment involving eye-tracking.

    PubMed

    Bialkova, Svetlana; Grunert, Klaus G; Juhl, Hans Jørn; Wasowicz-Kirylo, Grazyna; Stysko-Kunkowska, Malgorzata; van Trijp, Hans C M

    2014-05-01

    In two eye-tracking studies, we explored whether and how attention to nutrition information mediates consumers' choice. Consumers had to select either the healthiest option or a product of their preference within an assortment. On each product a particular label (Choices logo, monochrome GDA label, or color-coded GDA label) communicated the product's nutrient profile. In study 1, participants had to select from 4 products differentiated, in addition to the nutrition information, by flavor (strawberry, muesli, apple, chocolate; varied within participants) and brand (local vs. global, varied between participants). Study 2 further explored brand effect within-participants, and thus only 2 flavors (strawberry, chocolate) were presented within an assortment. Actual choice made, response time and eye movements were recorded. Respondents fixated longer and more often on products with color-coded GDAs label than on products with monochrome GDAs or Choices logo. A health goal resulted in longer and more frequent fixations in comparison to a preference goal. Products with color-coded and monochrome GDAs had the highest likelihood of being chosen, and this effect was related to the attention-getting property of the label (irrespective of brand and flavor effects). The product fixated most had the highest likelihood of being chosen. These results suggest that attention mediates the effect of nutrition labels on choice. PMID:24503332

  19. LIVE DEMONSTRATION OF DISTANT EARLY WARNING SYSTEM

    NASA Astrophysics Data System (ADS)

    Hammitzsch, M.; Lendholt, M.; Wächter, J.

    2009-12-01

    The DEWS (Distant Early Warning System) [1] project, funded under the 6th Framework Programme of the European Union, has the objective to create a new generation of interoperable early warning systems based on an open sensor platform. This platform integrates OGC [2] SWE [3] compliant sensor systems for the rapid detection of earthquakes, for the monitoring of sea level, ocean floor events, and ground displacements. Based on the upstream information flow DEWS focuses on the improvement of downstream capacities of warning centres especially by improving information logistics for effective and targeted warning message aggregation for a multilingual environment. Multiple telecommunication channels will be used for the dissemination of warning messages. Wherever possible, existing standards have been integrated. The Command and Control User Interface (CCUI), a rich client application based on Eclipse RCP (Rich Client Platform) [4] and the open source GIS uDig [5], integrates various OGC services. Using WMS (Web Map Service) [6] and WFS (Web Feature Service) [7] spatial data are utilized to depict the situation picture and to integrate a simulation system via WPS (Web Processing Service) [8] to identify affected areas. Warning messages are compiled and transmitted in the OASIS [9] CAP (Common Alerting Protocol) [10] standard together with addressing information defined via EDXL-DE (Emergency Data Exchange Language - Distribution Element) [11]. Internal interfaces are realized with SOAP [12] web services. Based on results of GITEWS [13] - in particular the GITEWS Tsunami Service Bus [14] - the DEWS approach provides an implementation for tsunami early warning systems. The introductory part of the demonstration briefly explains the DEWS project, the CCUI in conjunction with operators’ workflow, the system architecture, details of information logistics and the virtual scenario of live demonstration. The live demonstration exhibits the CCUI on screen and the service

  20. Detect-to-warn scenarios for defense against airborne contaminants

    NASA Astrophysics Data System (ADS)

    Cousins, Daniel; Campbell, Steven D.; Joseph, Rose

    2004-12-01

    Detect-to-warn defense strategies against airborne contamination are based on providing warning to personnel to take temporary protective actions. The effectiveness of such detect-to-warn active strategies is measured by the reduction in contaminant exposure compared to passive exposure. Effectiveness depends on several factors, including the contaminant release and transport properties, the warning sensor performance and the protective actions taken. In this paper we analyze effectiveness for several specific scenarios where certain reasonable protective actions are assumed and sensor performance is varied. One type of scenario analyzed is the protection of outdoor personnel against an upwind instantaneous point release. Meteorological conditions such as wind speed, turbulence level and heat flux, which result in high exposure levels are assumed. Personnel are warned to temporarily use filter masks based on a warning signal from a sensor placed between them and the release point. Another type of scenario is the protection of personnel inside of a building using active ventilation control. The building air handling properties, such as air exchange and recirculation, degree of leakage and filtration and zone volume, are representative of modern office buildings. Different sensor locations and ventilation control strategies are chosen to defend against outside and inside instantaneous point releases. In each scenario, we evaluate the dependence of effectiveness on sensor sensitivity threshold and response time. In addition, we describe desired values of other sensor attributes, such as false positive sensing rate, size, power consumption, maintenance frequency and procurement cost, to support realistic deployment and operations.

  1. Effects of Labeling Thiophilic FRET Dyes on the Stability and Dimerization Process of β-Lactoglobulin

    NASA Astrophysics Data System (ADS)

    Pan, Hai; Xie, Jin-Bing; Cao, Yi; Qin, Meng; Wang, Wei

    2011-11-01

    The stability and dimeric state of β-lactoglobulin (β-lg) can be dramatically affected by labeling the thiophilic agent to Cys121, whereas the underlining mechanism of such an effect is still unclear. We label a fluorescence-resonance-energy-transfer (FRET) pair of donor (1,5-IAEDANS) and acceptor (5-IAF) dyes to Cys121 of β-lg monomers to investigate the effect of bulky thiophilic modification on the structure and stability of β-lg. It is found that the modification dramatically destroys the native structure of β-lg and results in an obvious increase of the α-helical content, coincident with the accumulation of non-native α-helical intermediates during its folding process. Importantly, the dimeric state of β-lg can still be reached whereas its dimerization rate decreases dramatically, allowing us to characterize the dimerization process using the FRET method based on a stopped-flow apparatus. Our results reveal that the dimerization process occurs before the completely folding of individual monomers, providing direct evidence on the cooperativity of folding and binding processes.

  2. Effects of Ferumoxides – Protamine Sulfate Labeling on Immunomodulatory Characteristics of Macrophage-like THP-1 Cells

    PubMed Central

    Janic, Branislava; Iskander, A. S. M.; Rad, Ali M.; Soltanian-Zadeh, Hamid; Arbab, Ali S.

    2008-01-01

    Superparamagnetic Iron Oxide (SPIO) complexed with cationic transfection agent is used to label various mammalian cells. Labeled cells can then be utilized as an in vivo magnetic resonance imaging (MRI) probes. However, certain number of in vivo administered labeled cells may be cleared from tissues by the host's macrophages. For successful translation to routine clinical application of SPIO labeling method it is important that this mode of in vivo clearance of iron does not elicit any diverse immunological effects. The purpose of this study was to demonstrate that SPIO agent ferumoxides-protamine sulfate (FePro) incorporation into macrophages does not alter immunological properties of these cells with regard to differentiation, chemotaxis, and ability to respond to the activation stimuli and to modulate T cell response. We used THP-1 cell line as a model for studying macrophage cell type. THP-1 cells were magnetically labeled with FePro, differentiated with 100 nM of phorbol ester, 12-Myristate-13-acetate (TPA) and stimulated with 100 ng/ml of LPS. The results showed 1) FePro labeling had no effect on the changes in morphology and expression of cell surface proteins associated with TPA induced differentiation; 2) FePro labeled cells responded to LPS with slightly higher levels of NFκB pathway activation, as shown by immunobloting; TNF-α secretion and cell surface expression levels of CD54 and CD83 activation markers, under these conditions, were still comparable to the levels observed in non-labeled cells; 3) FePro labeling exhibited differential, chemokine dependent, effect on THP-1 chemotaxis with a decrease in cell directional migration to MCP-1; 4) FePro labeling did not affect the ability of THP-1 cells to down-regulate T cell expression of CD4 and CD8 and to induce T cell proliferation. Our study demonstrated that intracellular incorporation of FePro complexes does not alter overall immunological properties of THP-1 cells. The described experiments provide

  3. Effect of metabolism on retention of indium-111-labeled monoclonal antibody in liver and blood

    SciTech Connect

    Kinuyfa, S.; Jeong, J.M.; Garmestani, K.

    1994-11-01

    The effect of a chelator structure on the metabolic fate of the {sup 111}In-labeled monoclonal antibody (Mab) T101 was investigated in normal Balb/c mice to assess the importance of this chemical parameter in the reduction of the background radioactivity in blood and liver. Mab T101 was conjugated with either 2-(p-isothiocyanatobenzyl)-6-methyl-diethylaminetriaminepentaacetic acid (DTPA) (1B4M), 2-(p-isothiocyanatobenzyl) cyclohexyl-DTPA (CHX-B) or cyclic DTPA dianhydride (cDTPA) and then radiolabeled with {sup 111}In-labeled T101 conjugates and sacrificed in groups of five up to 5 days postinjection for comparative biodistribution studies and analyses of liver, blood and urine samples for radioindium products. The biodistribution of {sup 111}In-1B4M-T101 and {sup 111}In-CHX-B-T101 were similar to each other but significantly different from that of {sup 111}In-cDTPA-T101, particularly in the blood and liver. Size-exclusion high-performance liquid chromatography indicated that the concentration of the intact {sup 111}In-immunoglobulin (Ig)G in liver decreased with similar rates for the three conjugates. Meanwhile, the concentration of a small DTPA-like metabolite in liver increased to a different peak value (4.6% 1D/g for the cDTPA conjugate and 1.6% lD/g for the 1B4M and CHX-B conjugates) approximately at 24 hr and maintained a steady-state concentration up to 5 days. The thiourea linkage between T101 and the {sup 111}In-labeled chelates and a higher complex stability and higher lipophilicity of {sup 111}In-1B4M and {sup 111}In-CHX-B appear to be responsible for lower liver and higher blood radioactivity for the 1B4M and CHX conjugates. 31 refs., 3 figs., 1 tab.

  4. Satellite Threat Warning and Attack Reporting

    SciTech Connect

    Hilland, D.; Phipps, G.; Jingle, C.; Newton, G.

    1997-12-31

    The Air Force Research Laboratory`s Satellite Threat Warning and Attack Reporting (STW/AR) program will provide technologies for advanced threat warning and reporting of radio frequency (RF) and laser threats. The STW/AR program objectives are: (a) develop cost- effective technologies to detect, identify, locate, characterize, and report attacks or interference against U.S. and Allied satellites. (b) demonstrate innovative, light-weight, low-power, laser and RF sensors. The program focuses on the demonstration of RF and laser sensors. The RF sensor effort includes the investigation of interferometric antenna arrays, multi-arm spiral and butler matrix antennas, wideband receivers, adaptive processors, and improved processing algorithms. The laser sensor effort includes the investigation of alternative detectors, broadband grating and optical designs, active pixel sensing, and improved processing algorithms.

  5. Active biomonitoring in freshwater environments: early warning signals from biomarkers in assessing biological effects of diffuse sources of pollutants

    NASA Astrophysics Data System (ADS)

    Wepener, V.; van Vuren, J. H. J.; Chatiza, F. P.; Mbizi, Z.; Slabbert, L.; Masola, B.

    Effluents are a main source of direct and continuous input of pollutants in aquatic ecosystems. Relating observed effects to specific pollutants or even classes of pollutants remains a very difficult task due to the usually unknown, complex and often highly variable composition of effluents. It is recognized that toxicants interfere with organism integrity at the biochemical level and give rise to effects at the individual level and is manifested in reduced ecologically relevant characteristics such as growth, reproduction and survival, and ultimately at the ecosystem level. By integrating multiple endpoints at different ecologically relevant levels of organization within one test organism, it should be possible to gain understanding in how different levels of organization within this organism respond to toxic exposure and how responses at these different levels are interrelated. This paper presents results from a field study in the Rietvlei Wetland system, Gauteng, South Africa using the freshwater mollusk ( Melanoides tuberculata) and freshwater fish ( Oreochromis mossambicus) as bioindicator organisms. Active biomonitoring (ABM) exposures were conducted where organisms were exposed for 28 days in an effluent dominated river during high flow conditions in April 2003. The river receives effluent from a wastewater treatment plant and an industrial complex, so that up to 75% of the total flow of the river is effluent-based. Effects of field exposure were determined using cellular biomarkers e.g. DNA damage, HSP 70, metallothionein, acetylcholine esterase, lactate dehydrogenase and ethoxyresorufin-o-deethylase activity. The results clearly indicate that although the traditional mortality-based whole effluent toxicity testing did not indicate any toxicity, the in situ exposed organisms were stressed. A multivariate statistical approach was particularly useful for integrating the biomarker responses and highlighting sites at which more detailed analysis of chemical

  6. Experimental evaluation of fog warning system.

    PubMed

    Al-Ghamdi, Ali S

    2007-11-01

    Highway safety is a major concern to the public and to transportation professionals, so the number of crashes caused by poor visibility due to fog form an alarming statistic. Drivers respond to poor visibility conditions in different ways: some slow down; others do not. Many drivers simply follow the taillights of the vehicle ahead. Accordingly, hazardous conditions are created in which speeds are both too high for the prevailing conditions and highly variable. Findings are presented from a study of traffic crashes due to fog in the southern region of Saudi Arabia. The primary objective was to assess the effectiveness of fog detection and warning system on driver behavior regarding speed and headway. This warning system includes visibility sensors that automatically activate a variable message sign that posts an advisory speed when hazardous conditions due to fog occur. The system was installed on a 2 km section of a two-lane, rural highway. A data set of 36,013 observations from both experimental and control sections at two study sites was collected and analyzed. The data included vehicle speed, volume, and classification; time headway, time of day, and visibility distance. Although the warning system was ineffective in reducing speed variability, mean speed throughout the experimental sections was reduced by about 6.5 kph. This reduction indicates that the warning system appeared to have a positive effect on driver behavior in fog even though the observed mean speeds were still higher than the posted advisory speed. From relationships found in the literature between mean driving speed and number of crashes, a speed reduction of only 5 kph would yield a 15% decrease in the number of crashes.

  7. Disentangling the Origin of the Kok Effect Using Position Specific Glucose Labeling in Sunflower Leaves

    NASA Astrophysics Data System (ADS)

    Gauthier, P. P.; Bender, M. L.; Saenz, N.

    2015-12-01

    In plants, leaf mitochondrial respiratory CO2 release is inhibited by light. Bessel Kok first demonstrated this inhibition in 1948. Based on curves of CO2 assimilation vs irradiance, it is understood that respiration is maximal in the dark. It then frequently decreases linearly with irradiance until reaching some value around the compensation point, beyond which it is constant. CO2 released by mitochondrial respiration is the result of decarboxylation through pyruvate dehydrogenase (PDH), the tricarboxylic acid pathway (TCAP) and the oxydative pentose phosphate pathway (OPPP). The overall activity of these three reactions is reduced by light. However, their individual contributions to the Kok effect are unknown. We measured the rate of decarboxylation of glucose, position-specifically labeled with 13C, to evaluate the participation of PDH, TCAP and OPPP in the Kok effect of sunflower. Leaves were fed with labeled glucose through their transpiration stream. The δ13C of the CO2 released by the leaf was then measured as a function of irradiance. The results showed that the inhibition of the decarboxylation of carbon positions 3 and 4 in glucose is at the origin of the Kok effect. These are the positions of carbon atoms decarboxylated by PDH. In addition, the rate of decarboxylation of position 1 was not different in the light and in the dark. Thus OPPP plays no role in the Kok effect in sunflower leaves. This work improves our current understanding of leaf mitochondrial respiratory metabolism in the light. Invoking the Kok effect in plant physiology models should improve our ability to simulate carbon fluxes of terrestrial ecosystems.

  8. Impact of the new Malaysian cigarette pack warnings on smokers' awareness of health risks and interest in quitting smoking.

    PubMed

    Fathelrahman, Ahmed I; Omar, Maizurah; Awang, Rahmat; Cummings, K Michael; Borland, Ron; Bin Mohd Samin, Ahmad Shalihin

    2010-11-01

    The objective of this research was to compare the response of adult smokers in Malaysia to newly proposed pictorial cigarette warnings against the current text-only warnings. The study population included 140 adult male smokers who were enrolled in a randomized trial to view either the new pictorial warnings (intervention) or the old text-only warnings (control). Participants completed pre-exposure and post-exposure questionnaires that assessed their awareness of the health risks of smoking, response to the package warnings, and interest in quitting smoking. Exposure to the pictorial warnings resulted in increased awareness of the risks of smoking, stronger behavioral response to the warnings and increased interest in quitting smoking. The new warnings in Malaysia will increase smokers' knowledge of the adverse health effects of smoking and have a positive effect on interest in quitting.

  9. Epidural steroid warning controversy still dogging FDA.

    PubMed

    Manchikanti, Laxmaiah; Candido, Kenneth D; Singh, Vijay; Gharibo, Christopher G; Boswell, Mark V; Benyamin, Ramsin M; Falco, Frank J E; Grider, Jay S; Diwan, Sudhir; Hirsch, Joshua A

    2014-01-01

    On April 23, 2014, the Food and Drug Administration (FDA) issued a letter of warning that injection of corticosteroids into the epidural space of the spine may result in rare, but serious adverse events, including "loss of vision, stroke, paralysis, and death." The advisory also advocated that patients should discuss the benefits and risks of epidural corticosteroid injections with their health care professionals, along with the benefits and risks associated with other possible treatments. In addition, the FDA stated that the effectiveness and safety of the corticosteroids for epidural use have not been established, and the FDA has not approved corticosteroids for such use. To raise awareness of the risks of epidural corticosteroid injections in the medical community, the FDA's Safe Use Initiative convened a panel of experts including pain management experts to help define the techniques for such injections with the aim of reducing preventable harm. The panel was unable to reach an agreement on 20 proposed items related to technical aspects of performing epidural injections. Subsequently, the FDA issued the above referenced warning and a notice that a panel will be convened in November 2014. This review assesses the inaccuracies of the warning and critically analyzes the available literature. The literature has been assessed in reference to alternate techniques and an understanding of the risk factors when performing transforaminal epidural injections in the cervical, thoracic, and lumbar regions, ultimately resulting in improved safety. The results of this review show the efficacy of epidural injections, with or without steroids, in a multitude of spinal ailments utilizing caudal, cervical, thoracic, and lumbar interlaminar approaches as well as lumbar transforaminal epidural injections . The evidence also shows the superiority of steroids in managing lumbar disc herniation utilizing caudal and lumbar interlaminar approaches without any significant difference as

  10. Potential Effect of Physical Activity Calorie Equivalent (PACE) Labeling on Adult Fast Food Ordering and Exercise

    PubMed Central

    Antonelli, Ray; Viera, Anthony J.

    2015-01-01

    Introduction Numeric calorie content labels show limited efficacy in reducing the number of calories ordered from fast food meals. Physical activity calorie equivalent (PACE) labels are an alternative that may reduce the number of calories ordered in fast food meals while encouraging patrons to exercise. Methods A total of 1000 adults from 47 US states were randomly assigned via internet survey to one of four generic fast food menus: no label, calories only, calories + minutes, or calories + miles necessary to walk to burn off the calories. After completing hypothetical orders participants were asked to rate the likelihood of calorie-only and PACE labels to influence (1) food choice and (2) physical activity. Results Respondents (n = 823) ordered a median of 1580 calories from the no-label menu, 1200 from the calories-only menu, 1140 from the calories + minutes menu, and 1210 from the calories + miles menu (p = 0.0001). 40% of respondents reported that PACE labels were “very likely” to influence food item choice vs. 28% for calorie-only labels (p<0.0001). 64% of participants reported that PACE labels were “somewhat likely” or “very likely” to influence their level of physical activity vs. 49% for calorie-only labels (p<0.0001). Conclusions PACE labels may be helpful in reducing the number of calories ordered in fast food meals and may have the added benefit of encouraging exercise. PMID:26222056

  11. 21 CFR 740.10 - Labeling of cosmetic products for which adequate substantiation of safety has not been obtained.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 7 2014-04-01 2014-04-01 false Labeling of cosmetic products for which adequate..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS Warning Statements § 740.10 Labeling of cosmetic products for which adequate substantiation of safety has not...

  12. 21 CFR 740.10 - Labeling of cosmetic products for which adequate substantiation of safety has not been obtained.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Labeling of cosmetic products for which adequate..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS Warning Statements § 740.10 Labeling of cosmetic products for which adequate substantiation of safety has not...

  13. 21 CFR 740.10 - Labeling of cosmetic products for which adequate substantiation of safety has not been obtained.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 7 2012-04-01 2012-04-01 false Labeling of cosmetic products for which adequate..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS Warning Statements § 740.10 Labeling of cosmetic products for which adequate substantiation of safety has not...

  14. 21 CFR 740.10 - Labeling of cosmetic products for which adequate substantiation of safety has not been obtained.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Labeling of cosmetic products for which adequate..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS Warning Statements § 740.10 Labeling of cosmetic products for which adequate substantiation of safety has not...

  15. 21 CFR 740.10 - Labeling of cosmetic products for which adequate substantiation of safety has not been obtained.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 7 2013-04-01 2013-04-01 false Labeling of cosmetic products for which adequate..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS Warning Statements § 740.10 Labeling of cosmetic products for which adequate substantiation of safety has not...

  16. What's in a Name? Evaluating the Effects of the "Sex Offender" Label on Public Opinions and Beliefs.

    PubMed

    Harris, Andrew J; Socia, Kelly M

    2016-10-01

    Particularly over the past two decades, the terms sex offender and juvenile sex offender (JSO) have attained increasingly common usage in media and public policy discourse. Although often applied as factual descriptors, the labels may evoke strong subconscious associations with a population commonly presumed to be compulsive, at high risk of re-offense, and resistant to rehabilitation. Such associations, in turn, may exert considerable impact on expressions of support for certain policies as well as public beliefs and opinions about adults and youth who have perpetrated sexual offenses. The current study systematically evaluated the impact of the "sex offender" and "JSO" labels through series of items administered to a nationally stratified and matched sample from across the United States. The study employed an experimental design, in which one group of participants (n = 498) ranked their levels of agreement with a series of statements utilizing these labels, and a control group (n = 502) responded to a matched set of statements substituting the labels with more neutral descriptive language. Findings support the hypothesis that use of the "sex offender" label strengthens public support for policies directed at those who have perpetrated sexual crimes, including public Internet disclosure, residency restrictions, and social networking bans. The "JSO" label is demonstrated to produce particularly robust effects, enhancing support for policies that subject youth to public Internet notification and affecting beliefs about youths' propensity to re-offend as adults. Implications for public policy, media communication, and research are explored and discussed.

  17. Effect of the label of oligosaccharide acceptors on the kinetic parameters of nasturtium seed xyloglucan endotransglycosylase (XET).

    PubMed

    Kosík, Ondřej; Garajová, Soňa; Matulová, Mária; Rehulka, Pavel; Stratilová, Eva; Farkaš, Vladimír

    2011-02-01

    Fluorescently labeled derivatives of a xyloglucan (XG) nonasaccharide Glc(4)Xyl(3)Gal(2) (XLLG) were used as glycosyl acceptors in assays of xyloglucan endotransglycosylase (XET) from germinated nasturtium (Tropaeolum majus) seeds. We have investigated how the type of the oligosaccharide label influences the kinetic parameters of the reaction. The fluorescent probes used to label XLLG were anthranilic acid (AA), 8-aminonaphtalene-1,3,6-trisulfonic acid (ANTS), fluorescein isothiocyanate (FITC), and sulforhodamine (SR), respectively. The obtained data were compared with those of the reactions where aldose and/or alditol forms of tritium-labeled xyloglucan-derived nonasaccharide served as the respective acceptors. Modification at C-1 of the reducing-end glucose in XLLG by substitution with the fluorophore markedly affected the kinetic parameters of the reaction. The Michaelis constants K(m) for individual acceptors increased in the order [1-(3)H]XLLGXLLG-SR>XLLG-ANTS>[1-(3)H]XLLGol>[1-(3)H]XLLG>XLLG-AA. Catalytic efficiency (expressed as k(cat)/K(m)) with XLLG labeled with SR or FITC was 15 and 28 times, respectively, higher than with the tritium-labeled natural substrate [1-(3)H]XLLG. Comparison of the kinetic parameters found with acceptors labeled with different types of labels enables to select the most effective substrates for the high-throughput assays of XET.

  18. 49 CFR 172.407 - Label specifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Street, SW., Washington DC 20590-0001. (5) The following color standards in the PANTONE ® formula guide... markings and hazard warning labels and placards: (i) For Red—Use PANTONE ® 186 U (ii) For Orange—Use PANTONE ® 151 U (iii) For Yellow—Use PANTONE ® 109 U (iv) For Green—Use PANTONE ® 335 U (v) For...

  19. 21 CFR 660.45 - Labeling.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.45 Labeling. In... capable of transmitting hepatitis and should be handled accordingly. (d) The package shall include a... test methods, and (3) warnings as to possible hazards, including hepatitis transmitted in handling...

  20. 21 CFR 660.45 - Labeling.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.45 Labeling. In... capable of transmitting hepatitis and should be handled accordingly. (d) The package shall include a... test methods, and (3) warnings as to possible hazards, including hepatitis transmitted in handling...

  1. 21 CFR 660.45 - Labeling.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.45 Labeling. In... capable of transmitting hepatitis and should be handled accordingly. (d) The package shall include a... test methods, and (3) warnings as to possible hazards, including hepatitis transmitted in handling...

  2. 21 CFR 660.45 - Labeling.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.45 Labeling. In... capable of transmitting hepatitis and should be handled accordingly. (d) The package shall include a... test methods, and (3) warnings as to possible hazards, including hepatitis transmitted in handling...

  3. 21 CFR 660.45 - Labeling.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR DIAGNOSTIC SUBSTANCES FOR LABORATORY TESTS Hepatitis B Surface Antigen § 660.45 Labeling. In... capable of transmitting hepatitis and should be handled accordingly. (d) The package shall include a... test methods, and (3) warnings as to possible hazards, including hepatitis transmitted in handling...

  4. Potential Impact of Graphic Health Warnings on Cigarette Packages in Reducing Cigarette Demand and Smoking-Related Deaths in Vietnam.

    PubMed

    Minh, Hoang Van; Chung, Le Hong; Giang, Kim Bao; Duc, Duong Minh; Hinh, Nguyen Duc; Mai, Vu Quynh; Cuong, Nguyen Manh; Manh, Pham Duc; Duc, Ha Anh; Yang, Jui-Chen

    2016-01-01

    Two years after implementation of the graphic health warning intervention in Vietnam, it is very important to evaluate the intervention's potential impact. The objective of this paper was to predict effects of graphic health warnings on cigarette packages, particularly in reducing cigarette demand and smoking-associated deaths in Vietnam. In this study, a discrete choice experiment (DCE) method was used to evaluate the potential impact of graphic tobacco health warnings on smoking demand. To predict the impact of GHWs on reducing premature deaths associated with smoking, we constructed different static models. We adapted the method developed by University of Toronto, Canada and found that GHWs had statistically significant impact on reducing cigarette demand (up to 10.1% through images of lung damage), resulting in an overall decrease of smoking prevalence in Vietnam. We also found that between 428,417- 646,098 premature deaths would be prevented as a result of the GHW intervention. The potential impact of the GHW labels on reducing premature smoking-associated deaths in Vietnam were shown to be stronger among lower socio-economic groups. PMID:27087188

  5. Potential Impact of Graphic Health Warnings on Cigarette Packages in Reducing Cigarette Demand and Smoking-Related Deaths in Vietnam.

    PubMed

    Minh, Hoang Van; Chung, Le Hong; Giang, Kim Bao; Duc, Duong Minh; Hinh, Nguyen Duc; Mai, Vu Quynh; Cuong, Nguyen Manh; Manh, Pham Duc; Duc, Ha Anh; Yang, Jui-Chen

    2016-01-01

    Two years after implementation of the graphic health warning intervention in Vietnam, it is very important to evaluate the intervention's potential impact. The objective of this paper was to predict effects of graphic health warnings on cigarette packages, particularly in reducing cigarette demand and smoking-associated deaths in Vietnam. In this study, a discrete choice experiment (DCE) method was used to evaluate the potential impact of graphic tobacco health warnings on smoking demand. To predict the impact of GHWs on reducing premature deaths associated with smoking, we constructed different static models. We adapted the method developed by University of Toronto, Canada and found that GHWs had statistically significant impact on reducing cigarette demand (up to 10.1% through images of lung damage), resulting in an overall decrease of smoking prevalence in Vietnam. We also found that between 428,417- 646,098 premature deaths would be prevented as a result of the GHW intervention. The potential impact of the GHW labels on reducing premature smoking-associated deaths in Vietnam were shown to be stronger among lower socio-economic groups.

  6. Effect of chronicity of infection on the sensitivity of the In-111-labeled leukocyte scan

    SciTech Connect

    Datz, F.L.; Thorne, D.A.

    1986-10-01

    This study was undertaken to determine the effect of chronicity of infection on the sensitivity of In-111-labeled leukocyte scanning. A total of 332 scans on 290 patients were reviewed retrospectively. The diagnosis of infection was based on culture results and other laboratory data, autopsy findings, radiographic studies, and clinical course. Duration of infection at the time of scanning was determined by the date of onset of fever and symptoms, elevation of white cell count, positive cultures, and abnormal findings on radiographic studies. Sensitivity of leukocyte scanning was 90% for 69 patients who had infections for 0-14 days and 86% for 86 who had infections for 15 days or longer. This difference is not statistically significant.

  7. High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules.

    PubMed

    Sandhu, Adarsh; Kumagai, Yoshimichi; Lapicki, Adam; Sakamoto, Satoshi; Abe, Masanori; Handa, Hiroshi

    2007-04-15

    Detection of magnetically labeled biomolecules using micro-Hall biosensors is a promising method for monitoring biomolecular recognition processes. The measurement efficiency of standard systems is limited by the time taken for magnetic beads to reach the sensing area of the Hall devices. Here, micro-current lines were integrated with Hall effect structures to manipulate the position of magnetic beads via field gradients generated by localized currents flowing in the current lines. Beads were accumulated onto the sensor surface within seconds of passing currents through the current lines. Real-time detection of magnetic beads using current lines integrated with Hall biosensors was achieved. These results are promising in establishing Hall biosensor platforms as efficient and inexpensive means of monitoring biomolecular reactions for medical applications.

  8. Potential effect of physical activity based menu labels on the calorie content of selected fast food meals.

    PubMed

    Dowray, Sunaina; Swartz, Jonas J; Braxton, Danielle; Viera, Anthony J

    2013-03-01

    In this study we examined the effect of physical activity based labels on the calorie content of meals selected from a sample fast food menu. Using a web-based survey, participants were randomly assigned to one of four menus which differed only in their labeling schemes (n=802): (1) a menu with no nutritional information, (2) a menu with calorie information, (3) a menu with calorie information and minutes to walk to burn those calories, or (4) a menu with calorie information and miles to walk to burn those calories. There was a significant difference in the mean number of calories ordered based on menu type (p=0.02), with an average of 1020 calories ordered from a menu with no nutritional information, 927 calories ordered from a menu with only calorie information, 916 calories ordered from a menu with both calorie information and minutes to walk to burn those calories, and 826 calories ordered from the menu with calorie information and the number of miles to walk to burn those calories. The menu with calories and the number of miles to walk to burn those calories appeared the most effective in influencing the selection of lower calorie meals (p=0.0007) when compared to the menu with no nutritional information provided. The majority of participants (82%) reported a preference for physical activity based menu labels over labels with calorie information alone and no nutritional information. Whether these labels are effective in real-life scenarios remains to be tested.

  9. Effect of HSA coated iron oxide labeling on human umbilical cord derived mesenchymal stem cells

    NASA Astrophysics Data System (ADS)

    Sanganeria, Purva; Chandra, Sudeshna; Bahadur, Dhirendra; Khanna, Aparna

    2015-03-01

    Human umbilical cord derived mesenchymal stem cells (hUC-MSCs) are known for self-renewal and differentiation into cells of various lineages like bone, cartilage and fat. They have been used in biomedical applications to treat degenerative disorders. However, to exploit the therapeutic potential of stem cells, there is a requirement of sensitive non-invasive imaging techniques which will offer the ability to track transplanted cells, bio-distribution, proliferation and differentiation. In this study, we have analyzed the efficacy of human serum albumin coated iron oxide nanoparticles (HSA-IONPs) on the differentiation of hUC-MSCs. The colloidal stability of the HSA-IONPs was tested over a long period of time (≥20 months) and the optimized concentration of HSA-IONPs for labeling the stem cells was 60 μg ml-1. Detailed in vitro assays have been performed to ascertain the effect of the nanoparticles (NPs) on stem cells. Lactate dehydrogenase (LDH) assay showed minimum release of LDH depicting the least disruptions in cellular membrane. At the same time, mitochondrial impairment of the cells was also not observed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Flow cytometry analysis revealed lesser generation of reactive oxygen species in HSA-IONPs labeled hUC-MSCs in comparison to bare and commercial IONPs. Transmission electron microscopy showed endocytic engulfment of the NPs by the hUC-MSCs. During the process, the gross morphologies of the actin cytoskeleton were found to be intact as shown by immunofluorescence microscopy. Also, the engulfment of the HSA-IONPs did not show any detrimental effect on the differentiation potential of the stem cells into adipocytes, osteocytes and chondrocytes, thereby confirming that the inherent properties of stem cells were maintained.

  10. Self-labeling and its effects among adolescents diagnosed with mental disorders.

    PubMed

    Moses, Tally

    2009-02-01

    While youths are increasingly diagnosed with serious psychiatric disorders, little is known about how they conceptualize their own problems or the impact of mental illness labels on their psychological well-being. These are matters of great concern because of the potential vulnerability of young people to stigma as well as the fact that fear of labels or anticipation of stigma are common barriers to adolescents' ongoing mental health service utilization. This study uses mixed-method interviews with 54 US adolescents receiving integrated mental health services in a mid-sized mid-Western city to examine: (1) the extent to which they use psychiatric terms to refer to their problems ("self-label"), and (2) the relationships between adolescents' self-labeling and indicators of psychological well-being (self-esteem, mastery, depression and self-stigma). Associations between self-labeling and perceived negative treatment by others (public-stigma), clinical and demographic factors are explored to identify which adolescents are more likely to self-label. Based on Modified Labeling Theory [Link, B., Cullen, F., & Struening, E. (1989). A modified labeling theory approach to mental disorders: An empirical assessment. American Sociological Review, 54(3), 400-423.] and Thoits's [(1985). Self-labeling processes in mental illness: The role of emotional deviance. American Journal of Sociology, 91(2), 221-249.] work on self-labeling, it was expected that many youth would not self-label and that self-labelers would demonstrate poorer psychological well-being. As expected, the findings indicated that only a minority of adolescents 'self-labeled'. Most conceptualized their problems in non-pathological terms or demonstrated uncertainty or confusion about the nature of their problems. Adolescent who self-labeled reported higher ratings on self-stigma and depression, and a trend toward a lower sense of mastery, but there was no association with self-esteem. Certain characteristics and

  11. 77 FR 27591 - Labeling and Effectiveness Testing; Sunscreen Drug Products for Over-the-Counter Human Use; Delay...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... proposed rule (72 FR 49070 at 49073, August 27, 2007) and the 1999 sunscreen final rule (64 FR 27666 at... Federal Register of June 17, 2011 (76 FR 35620). The final rule establishes labeling and effectiveness.... The final rule published at 76 FR 35620 on June 17, 2011, remains effective June 18, 2012....

  12. Speech, "Inner Speech," and the Development of Short-Term Memory: Effects of Picture-Labeling on Recall.

    ERIC Educational Resources Information Center

    Hitch, Graham J.; And Others

    1991-01-01

    Reports on experiments to determine effects of overt speech on children's use of inner speech in short-term memory. Word length and phonemic similarity had greater effects on older children and when pictures were labeled at presentation. Suggests that speaking or listening to speech activates an internal articulatory loop. (Author/GH)

  13. Warning Signs of Vision Problems in Children

    MedlinePlus

    ... Text Size Email Print Share Warning Signs of Vision Problems in Infants & Children Page Content ​Eye exams ... treated successfully. What are warning signs of a vision problem? Babies up to 1 year of age: ...

  14. 49 CFR 193.2917 - Warning signs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES: FEDERAL SAFETY STANDARDS Security § 193.2917 Warning signs. (a) Warning signs must be conspicuously...

  15. Early Warning Implementation Guide: "Using the Massachusetts Early Warning Indicator System (EWIS) and Local Data to Identify, Diagnose, Support, and Monitor Students in Grades 1-12"

    ERIC Educational Resources Information Center

    Massachusetts Department of Elementary and Secondary Education, 2014

    2014-01-01

    The purpose of this guide is to provide information on how to use early warning data, including the Massachusetts Early Warning Indicator System (EWIS), to identify, diagnose, support and monitor students in grades 1-12. It offers educators an overview of EWIS and how to effectively use these data in conjunction with local data by following a…

  16. Effect of lie labelling on children's evaluation of selfish, polite, and altruistic lies.

    PubMed

    Cheung, Him; Chan, Yawen; Tsui, Wan Chi Gigi

    2016-09-01

    This study investigates how 5- and 6-year-olds' evaluations of selfish, polite, and altruistic lies change as a result of whether these false statements are explicitly labelled as lies. We are also interested in how interpretive theory of mind may correlate with such evaluations with and without a lie label. Our results showed that labelling lowered children's evaluations for the polite and altruistic lies, but not for the selfish lies. Interpretive theory of mind correlated positively with the evaluation difference between the polite and altruistic lies and that between the selfish and altruistic lies in the label, but not in the non-label condition. Correlation between the selfish and altruistic lies and that between the polite and altruistic lies were stronger with than without labelling, after controlling for age, and verbal and non-verbal intelligence. We conclude that lie labelling biases children towards more negative evaluations for non-selfish lies and makes them see lies of different motives as more similar. If a lie label is applied, whether lies of different motives are still evaluated differently depends on interpretive theory of mind, which reflects the child's ability to represent and allow different interpretations of an ambiguous reality.

  17. Automaticity of Basic-Level Categorization Accounts for Labeling Effects in Visual Recognition Memory

    ERIC Educational Resources Information Center

    Richler, Jennifer J.; Gauthier, Isabel; Palmeri, Thomas J.

    2011-01-01

    Are there consequences of calling objects by their names? Lupyan (2008) suggested that overtly labeling objects impairs subsequent recognition memory because labeling shifts stored memory representations of objects toward the category prototype (representational shift hypothesis). In Experiment 1, we show that processing objects at the basic…

  18. Women's Relationship to Feminism: Effects of Generation and Feminist Self-Labeling

    ERIC Educational Resources Information Center

    Duncan, Lauren E.

    2010-01-01

    The relative importance to feminism of generation and feminist self-labeling was explored in a sample of 667 women riding buses to a 1992 March on Washington for Reproductive Rights. Specifically, generational (Generation X vs. Baby Boomers) and feminist self-labeling (strong feminists vs. weak feminists vs. nonfeminists) similarities and…

  19. Effect of lie labelling on children's evaluation of selfish, polite, and altruistic lies.

    PubMed

    Cheung, Him; Chan, Yawen; Tsui, Wan Chi Gigi

    2016-09-01

    This study investigates how 5- and 6-year-olds' evaluations of selfish, polite, and altruistic lies change as a result of whether these false statements are explicitly labelled as lies. We are also interested in how interpretive theory of mind may correlate with such evaluations with and without a lie label. Our results showed that labelling lowered children's evaluations for the polite and altruistic lies, but not for the selfish lies. Interpretive theory of mind correlated positively with the evaluation difference between the polite and altruistic lies and that between the selfish and altruistic lies in the label, but not in the non-label condition. Correlation between the selfish and altruistic lies and that between the polite and altruistic lies were stronger with than without labelling, after controlling for age, and verbal and non-verbal intelligence. We conclude that lie labelling biases children towards more negative evaluations for non-selfish lies and makes them see lies of different motives as more similar. If a lie label is applied, whether lies of different motives are still evaluated differently depends on interpretive theory of mind, which reflects the child's ability to represent and allow different interpretations of an ambiguous reality. PMID:26748882

  20. Long-term effect of vital labelling on mixed Schwann cell cultures.

    PubMed

    Mosahebi, A; Woodward, B; Green, C; Martin, R; Terenghi, G

    2000-06-01

    Schwann cell transplantation following neuronal injury could encourage regeneration of spinal cord as well as improving peripheral nerve gap repair. In order to gain a better understanding of the role of transplanted Schwann cells in vivo, it is essential to be able to follow their behaviour after transplantation. Our aim was to evaluate the suitability of two vital fluorescent labels on the proliferation rate and phenotypic stability of Schwann cells, in either pure culture or mixed co-culture. Primary cultures of Schwann cells were obtained from Dark Agouti and Lewis neonatal rats and labelled with H33342 and PKH26, respectively. In mixed cultures, a 50: 50 mixture of Dark Agouti and Lewis Schwann cells was present. Labelled cultured cells were examined at 1, 2 and 4 weeks for viability and phenotypic marker expression of S100, GFAP, p75, MHC I, MHC II and compared with corresponding unlabelled cells. The results showed that although there was no deleterious interaction in the mixed cultures, the viability was reduced by the labelling after 2 weeks. Labelled cells could be distinguished up to 4 weeks, but there was leakage of H33342 label after 2 weeks. Labelled Schwann cells showed reduced expression of phenotypic markers, especially p75 when labelled with H33342. In conclusion, H33342 and PKH26 can be used as fluorescent markers of Schwann cells for short-term studies, for a maximum of 2 weeks, but different markers may be needed for longer experiments.

  1. Effects of Type A Personality and Task Labels (Work vs. Leisure) on Task Preference.

    ERIC Educational Resources Information Center

    Tang, Thomas Li-Ping

    1986-01-01

    Three groups of subjects (Type A, intermediate, and Type B) were presented an identical problem-solving task labeled as work-related or as leisure-oriented and then given free choice of other activities. The subjects' task preference in the free-choice time was examined as a function of Type A personality and task labels. (MT)

  2. Effects of Categorical Labels on Similarity Judgments: A Critical Analysis of Similarity-Based Approaches

    ERIC Educational Resources Information Center

    Noles, Nicholaus S.; Gelman, Susan A.

    2012-01-01

    Our goal in the present study was to evaluate the claim that category labels affect children's judgments of visual similarity. We presented preschool children with discriminable and identical sets of animal pictures and asked them to make perceptual judgments in the presence or absence of labels. Our findings indicate that children who are asked…

  3. Exploring the Role of Social Memory of Floods for Designing Flood Early Warning Operations

    NASA Astrophysics Data System (ADS)

    Girons Lopez, Marc; Di Baldassarre, Giuliano; Grabs, Thomas; Halldin, Sven; Seibert, Jan

    2016-04-01

    Early warning systems are an important tool for natural disaster mitigation practices, especially for flooding events. Warnings rely on near-future forecasts to provide time to take preventive actions before a flood occurs, thus reducing potential losses. However, on top of the technical capacities, successful warnings require an efficient coordination and communication among a range of different actors and stakeholders. The complexity of integrating the technical and social spheres of warning systems has, however, resulted in system designs neglecting a number of important aspects such as social awareness of floods thus leading to suboptimal results. A better understanding of the interactions and feedbacks among the different elements of early warning systems is therefore needed to improve their efficiency and therefore social resilience. When designing an early warning system two important decisions need to be made regarding (i) the hazard magnitude at and from which a warning should be issued and (ii) the degree of confidence required for issuing a warning. The first decision is usually taken based on the social vulnerability and climatic variability while the second one is related to the performance (i.e. accuracy) of the forecasting tools. Consequently, by estimating the vulnerability and the accuracy of the forecasts, these two variables can be optimized to minimize the costs and losses. Important parameters with a strong influence on the efficiency of warning systems such as social awareness are however not considered in their design. In this study we present a theoretical exploration of the impact of social awareness on the design of early warning systems. For this purpose we use a definition of social memory of flood events as a proxy for flood risk awareness and test its effect on the optimization of the warning system design variables. Understanding the impact of social awareness on warning system design is important to make more robust warnings that can

  4. 30 CFR 57.14214 - Train warnings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Train warnings. 57.14214 Section 57.14214... Equipment Safety Practices and Operational Procedures § 57.14214 Train warnings. A warning that is audible above the surrounding noise level shall be sounded— (a) Immediately prior to moving trains; (b)...

  5. 30 CFR 56.14214 - Train warnings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Train warnings. 56.14214 Section 56.14214... Safety Practices and Operational Procedures § 56.14214 Train warnings. A warning that is audible above the surrounding noise level shall be sounded— (a) Immediately prior to moving trains; (b) When...

  6. 30 CFR 57.14208 - Warning devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Warning devices. 57.14208 Section 57.14208... Equipment Safety Practices and Operational Procedures § 57.14208 Warning devices. (a) Visible warning devices shall be used when parked mobile equipment creates a hazard to persons in other mobile...

  7. 30 CFR 56.14208 - Warning devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Warning devices. 56.14208 Section 56.14208 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Safety Practices and Operational Procedures § 56.14208 Warning devices. (a) Visible warning devices...

  8. 46 CFR 154.1830 - Warning sign.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Warning sign. 154.1830 Section 154.1830 Shipping COAST... SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1830 Warning sign. (a) The master... a warning sign: (1) At the gangway facing the shore so that the sign may be seen from the shore;...

  9. 49 CFR 193.2917 - Warning signs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Warning signs. 193.2917 Section 193.2917...: FEDERAL SAFETY STANDARDS Security § 193.2917 Warning signs. (a) Warning signs must be conspicuously placed along each protective enclosure at intervals so that at least one sign is recognizable at night from...

  10. 49 CFR 193.2917 - Warning signs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Warning signs. 193.2917 Section 193.2917...: FEDERAL SAFETY STANDARDS Security § 193.2917 Warning signs. (a) Warning signs must be conspicuously placed along each protective enclosure at intervals so that at least one sign is recognizable at night from...

  11. 46 CFR 154.1830 - Warning sign.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Warning sign. 154.1830 Section 154.1830 Shipping COAST... SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1830 Warning sign. (a) The master... a warning sign: (1) At the gangway facing the shore so that the sign may be seen from the shore;...

  12. 49 CFR 193.2917 - Warning signs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Warning signs. 193.2917 Section 193.2917...: FEDERAL SAFETY STANDARDS Security § 193.2917 Warning signs. (a) Warning signs must be conspicuously placed along each protective enclosure at intervals so that at least one sign is recognizable at night from...

  13. 49 CFR 193.2917 - Warning signs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Warning signs. 193.2917 Section 193.2917...: FEDERAL SAFETY STANDARDS Security § 193.2917 Warning signs. (a) Warning signs must be conspicuously placed along each protective enclosure at intervals so that at least one sign is recognizable at night from...

  14. 16 CFR 307.2 - Required warnings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... THE COMPREHENSIVE SMOKELESS TOBACCO HEALTH EDUCATION ACT OF 1986 Scope § 307.2 Required warnings. The Comprehensive Smokeless Tobacco Health Education Act of 1986 is the law that requires the enactment of these... smokeless tobacco product. The warning statements required by the Act are as follows: WARNING: THIS...

  15. 30 CFR 56.14214 - Train warnings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Safety Practices and Operational Procedures § 56.14214 Train warnings. A warning that is audible above... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Train warnings. 56.14214 Section 56.14214 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  16. 30 CFR 56.14214 - Train warnings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Safety Practices and Operational Procedures § 56.14214 Train warnings. A warning that is audible above... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Train warnings. 56.14214 Section 56.14214 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  17. 30 CFR 57.14214 - Train warnings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Equipment Safety Practices and Operational Procedures § 57.14214 Train warnings. A warning that is audible... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Train warnings. 57.14214 Section 57.14214 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  18. 30 CFR 57.14214 - Train warnings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Equipment Safety Practices and Operational Procedures § 57.14214 Train warnings. A warning that is audible... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Train warnings. 57.14214 Section 57.14214 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  19. 30 CFR 57.14214 - Train warnings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Equipment Safety Practices and Operational Procedures § 57.14214 Train warnings. A warning that is audible... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Train warnings. 57.14214 Section 57.14214 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  20. 30 CFR 56.14214 - Train warnings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Safety Practices and Operational Procedures § 56.14214 Train warnings. A warning that is audible above... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Train warnings. 56.14214 Section 56.14214 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  1. Relative Importance of Different Attributes of Graphic Health Warnings on Tobacco Packages in Viet Nam.

    PubMed

    Giang, Kim Bao; Chung, Le Hong; Minh, Hoang Van; Kien, Vu Duy; Giap, Vu Van; Hinh, Nguyen Duc; Cuong, Nguyen Manh; Manh, Pham Duc; Duc, Ha Anh; Yang, Jui-Chen

    2016-01-01

    Graphic health warnings (GHW) on tobacco packages have proven to be effective in increasing quit attempts among smokers and reducing initial smoking among adolescents. This research aimed to examine the relative importance of different attributes of graphic health warnings on tobacco packages in Viet Nam. A discrete choice experimental (DCE) design was applied with a conditional logit model. In addition, a ranking method was used to list from the least to the most dreadful GHW labels. With the results from DCE model, graphic type was shown to be the most important attribute, followed by cost and coverage area of GHW. The least important attribute was position of the GHW. Among 5 graphic types (internal lung cancer image, external damaged teeth, abstract image, human suffering image and text), the image of lung cancer was found to have the strongest influence on both smokers and non-smokers. With ranking method, the image of throat cancer and heart diseases were considered the most dreadful images. GHWs should be designed with these attributes in mind, to maximise influence on purchase among both smokers and non-smokers. PMID:27087187

  2. Relative Importance of Different Attributes of Graphic Health Warnings on Tobacco Packages in Viet Nam.

    PubMed

    Giang, Kim Bao; Chung, Le Hong; Minh, Hoang Van; Kien, Vu Duy; Giap, Vu Van; Hinh, Nguyen Duc; Cuong, Nguyen Manh; Manh, Pham Duc; Duc, Ha Anh; Yang, Jui-Chen

    2016-01-01

    Graphic health warnings (GHW) on tobacco packages have proven to be effective in increasing quit attempts among smokers and reducing initial smoking among adolescents. This research aimed to examine the relative importance of different attributes of graphic health warnings on tobacco packages in Viet Nam. A discrete choice experimental (DCE) design was applied with a conditional logit model. In addition, a ranking method was used to list from the least to the most dreadful GHW labels. With the results from DCE model, graphic type was shown to be the most important attribute, followed by cost and coverage area of GHW. The least important attribute was position of the GHW. Among 5 graphic types (internal lung cancer image, external damaged teeth, abstract image, human suffering image and text), the image of lung cancer was found to have the strongest influence on both smokers and non-smokers. With ranking method, the image of throat cancer and heart diseases were considered the most dreadful images. GHWs should be designed with these attributes in mind, to maximise influence on purchase among both smokers and non-smokers.

  3. Same faces, different labels: generating the cross-race effect in face memory with social category information.

    PubMed

    Hourihan, Kathleen L; Fraundorf, Scott H; Benjamin, Aaron S

    2013-10-01

    Recognition of own-race faces is superior to recognition of other-race faces. In the present experiments, we explored the role of top-down social information in the encoding and recognition of racially ambiguous faces. Hispanic and African American participants studied and were tested on computer-generated ambiguous-race faces (composed of 50 % Hispanic and 50 % African American features; MacLin & Malpass, Psychology, Public Policy, and Law 7:98-118, 2001). In Experiment 1, the faces were randomly assigned to two study blocks. In each block, a group label was provided that indicated that those faces belonged to African American or to Hispanic individuals. Both participant groups exhibited superior memory for faces studied in the block with their own-race label. In Experiment 2, the faces were studied in a single block with no labels, but tested in two blocks in which labels were provided. Recognition performance was not influenced by the labeled race at test. Taken together, these results confirm the claim that purely top-down information can yield the well-documented cross-race effect in recognition, and additionally they suggest that the bias takes place at encoding rather than testing.

  4. Same Faces, Different Labels: Generating the Cross-Race Effect in Face Memory with Social Category Information

    PubMed Central

    Hourihan, Kathleen L.; Fraundorf, Scott H.; Benjamin, Aaron S.

    2013-01-01

    Recognition of own-race faces is superior to recognition of other-race faces. In the present experiments, we explore the role of top-down social information in the encoding and recognition of racially ambiguous faces. Hispanic and African-American participants studied and were tested on computer-generated, ambiguous-race faces (composed of 50% Hispanic and 50% African-American features; MacLin & Malpass, 2001). In Experiment 1, faces were randomly assigned to two study blocks. In each block, a group label was provided that indicated that those faces belonged to African-American or to Hispanic individuals. Both participant groups exhibited superior memory for faces studied in the block with the own-race label. In Experiment 2, faces were studied in a single block with no labels, but tested in two blocks in which labels were provided. Recognition performance was not influenced by the labeled race at test. Taken together, these results confirm the claim that purely top-down information can yield the well documented cross-race effect in recognition, and additionally suggest that the bias takes place at encoding rather than testing. PMID:23546969

  5. 76 FR 55923 - Draft Guidance for Industry: Submission of Warning Plans for Cigarettes and Smokeless Tobacco...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... Cigarettes and Smokeless Tobacco Products; Availability; Agency Information Collection Activities; Proposed... ``Submission of Warning Plans for Cigarettes and Smokeless Tobacco Products.'' This draft guidance document is... Cigarette Labeling and Advertising Act, as amended by the Family Smoking Prevention and Tobacco Control...

  6. 77 FR 39710 - Draft Guidance for Industry on Organ-Specific Warnings: Internal Analgesic, Antipyretic, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ..., 2006 (71 FR 77314), FDA published a proposed rule on organ-specific warnings and related labeling for OTC IAAA drug products. In the Federal Register of April 29, 2009 (74 FR 19385), FDA published the final rule (2009 final rule). In the Federal Register of November 25, 2009 (74 FR 61512), FDA...

  7. Visual similarity effects on short-term memory for order: the case of verbally labeled pictorial stimuli.

    PubMed

    Poirer, Marie; Saint-Aubin, Jean; Musselwhite, Karen; Mohanadas, Thulasi; Mahammed, Ghuson

    2007-06-01

    Four experiments examined the effect of visual similarity on immediate memory for order. Experiments 1 and 2 used easily nameable line drawings. Following a sequential presentation in either silent or suppression conditions, participants were presented with the drawings in a new, random order and were required to remember their original serial position. In Experiment 3, participants first learned to associate a verbal label with an abstract matrix pattern. Then they completed an immediate memory task in which they had to name the matrices aloud during presentation. At recall, the task required remembering either the order of the matrices or the order of their names. In Experiment 4, participants learned to associate nonword labels with schematic line drawings of faces; the phonemic similarity of the verbal labels was also manipulated. All four experiments indicate that the representations supporting performance comprise both verbal and visual features. The results are consistent with a multiattribute encoding view.

  8. The effect of digital alteration disclaimer labels on social comparison and body image: Instructions and individual differences.

    PubMed

    Bury, Belinda; Tiggemann, Marika; Slater, Amy

    2016-06-01

    The current study aimed to investigate the effect of digital alteration disclaimer labels appended to fashion magazine advertisements, as well as instructional condition, on women's social comparison and body dissatisfaction. Participants were 378 female undergraduate students who viewed 11 thin ideal advertisements with either no disclaimer, a generic disclaimer, or a more detailed specific disclaimer. There were three instructional conditions: neutral, distractor, and social comparison. Disclaimer labels did not affect appearance comparison or body dissatisfaction, but instructional condition did, with the social comparison instructions producing the highest appearance comparison and body dissatisfaction. In addition, there was a three-way interaction with trait appearance comparison, such that women high on trait appearance comparison who saw specifically worded disclaimers in the distractor instructional condition experienced increased body dissatisfaction, whereas women low on this trait experienced decreased body dissatisfaction. It seems that both instructions and individual differences may influence responses to disclaimer labels. PMID:27061258

  9. The effect of the Psychopathy Checklist--Revised in capital cases: mock jurors' responses to the label of psychopathy.

    PubMed

    Cox, Jennifer; DeMatteo, David S; Foster, Elizabeth E

    2010-01-01

    Despite mixed empirical evidence regarding the ability of the Psychopathy Checklist - Revised (PCL-R) to predict violence among incarcerated inmates, it continues to be used to address such questions, even in the context of capital cases. The purpose of this study was to examine if the PCL-R has a prejudicial effect on mock jury members during the sentencing phase of a capital murder trial. Results indicated that participants were more likely to sentence the defendant to death when the defendant exhibited a high likelihood to commit future violence, whether or not the diagnostic label "psychopath" was present. Interestingly, when asked to rate the defendant's likelihood for future violence and murder, the defendant who was a high risk for future violence and not labeled a psychopath received the highest rating. These results suggest an absence of juror bias as it pertains to the label "psychopath" when sentencing a defendant in a capital murder case.

  10. Effect of salt on the structure of middle phase microemulsions using the spin-label technique

    SciTech Connect

    Ramachandran, C.; Vijayan, S.; Shah, D.O.

    1980-06-12

    The middle phases obtained by varying the sodium chloride concentration in surfactant formulations containing 5:3 (wt/wt) TRS 10-410 (a petroleum sulfonate)-isobutyl alcohol and equal volumes of aqueous and oil phases were studied by using spin-labeling techniques. Two different spin-labels, one partially water soluble (5-doxylstearic acid label) and the other water insoluble (3-doxylcholestane label), were used. Extensive measurements of electrical conductivity and phase volumes of the middle phases were also carried out. These physical property results corroborated the spin-label studies in that below 2.0 wt % NaCl the middle phase was essentially a microemulsion of the water external type. Beyond 2.3% NaCl the appearance of a signal component typical of a free label (ketostearic acid) in an oil environment and changes in correlation time characteristics (cholestane label) coupled with physical property data underlined a qualitative change in the microemulsion system. It is believed that these changes are consistent with a transition from a water-external type to an oil-external type microemulsion system. This transition is estimated to be around 2 to 2.3% NaCl. The results are further substantiated by ascorbic acid reduction rate studies. Possible mechanisms of this transition are discussed.

  11. 76 FR 38975 - Labeling and Effectiveness Testing; Sunscreen Drug Products for Over-the-Counter Human Use

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 201 (formerly Docket No. 1978N-0038) RIN 0910-AF43 Labeling and Effectiveness Testing; Sunscreen Drug Products for Over-the-Counter Human...

  12. On the importance of risk knowledge for an end-to-end tsunami early warning system

    NASA Astrophysics Data System (ADS)

    Post, Joachim; Strunz, Günter; Riedlinger, Torsten; Mück, Matthias; Wegscheider, Stephanie; Zosseder, Kai; Steinmetz, Tilmann; Gebert, Niklas; Anwar, Herryal

    2010-05-01

    context has been worked out. The generated results contribute significantly in the fields of (1) warning decision and warning levels, (2) warning dissemination and warning message content, (3) early warning chain planning, (4) increasing response capabilities and protective systems, (5) emergency relief and (6) enhancing communities' awareness and preparedness towards tsunami threats. Additionally examples will be given on the potentials of an operational use of risk information in early warning systems as first experiences exist for the tsunami early warning center in Jakarta, Indonesia. Beside this the importance of linking national level early warning information with tsunami risk information available at the local level (e.g. linking warning message information on expected intensity with respective tsunami hazard zone maps at community level for effective evacuation) will be demonstrated through experiences gained in three pilot areas in Indonesia. The presentation seeks to provide new insights on benefits using risk information in early warning and will provide further evidence that practical use of risk information is an important and indispensable component of end-to-end early warning.

  13. Label Propagation Prediction of Drug-Drug Interactions Based on Clinical Side Effects.

    PubMed

    Zhang, Ping; Wang, Fei; Hu, Jianying; Sorrentino, Robert

    2015-01-01

    Drug-drug interaction (DDI) is an important topic for public health, and thus attracts attention from both academia and industry. Here we hypothesize that clinical side effects (SEs) provide a human phenotypic profile and can be translated into the development of computational models for predicting adverse DDIs. We propose an integrative label propagation framework to predict DDIs by integrating SEs extracted from package inserts of prescription drugs, SEs extracted from FDA Adverse Event Reporting System, and chemical structures from PubChem. Experimental results based on hold-out validation demonstrated the effectiveness of the proposed algorithm. In addition, the new algorithm also ranked drug information sources based on their contributions to the prediction, thus not only confirming that SEs are important features for DDI prediction but also paving the way for building more reliable DDI prediction models by prioritizing multiple data sources. By applying the proposed algorithm to 1,626 small-molecule drugs which have one or more SE profiles, we obtained 145,068 predicted DDIs. The predicted DDIs will help clinicians to avoid hazardous drug interactions in their prescriptions and will aid pharmaceutical companies to design large-scale clinical trial by assessing potentially hazardous drug combinations. All data sets and predicted DDIs are available at http://astro.temple.edu/~tua87106/ddi.html. PMID:26196247

  14. Label Propagation Prediction of Drug-Drug Interactions Based on Clinical Side Effects.

    PubMed

    Zhang, Ping; Wang, Fei; Hu, Jianying; Sorrentino, Robert

    2015-01-01

    Drug-drug interaction (DDI) is an important topic for public health, and thus attracts attention from both academia and industry. Here we hypothesize that clinical side effects (SEs) provide a human phenotypic profile and can be translated into the development of computational models for predicting adverse DDIs. We propose an integrative label propagation framework to predict DDIs by integrating SEs extracted from package inserts of prescription drugs, SEs extracted from FDA Adverse Event Reporting System, and chemical structures from PubChem. Experimental results based on hold-out validation demonstrated the effectiveness of the proposed algorithm. In addition, the new algorithm also ranked drug information sources based on their contributions to the prediction, thus not only confirming that SEs are important features for DDI prediction but also paving the way for building more reliable DDI prediction models by prioritizing multiple data sources. By applying the proposed algorithm to 1,626 small-molecule drugs which have one or more SE profiles, we obtained 145,068 predicted DDIs. The predicted DDIs will help clinicians to avoid hazardous drug interactions in their prescriptions and will aid pharmaceutical companies to design large-scale clinical trial by assessing potentially hazardous drug combinations. All data sets and predicted DDIs are available at http://astro.temple.edu/~tua87106/ddi.html.

  15. Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase†

    PubMed Central

    Luk, Louis Y. P.; Ruiz‐Pernía, J. Javier; Adesina, Aduragbemi S.; Loveridge, E. Joel

    2015-01-01

    Abstract Chemical ligation has been used to alter motions in specific regions of dihydrofolate reductase from E. coli and to investigate the effects of localized motional changes on enzyme catalysis. Two isotopic hybrids were prepared; one with the mobile N‐terminal segment containing heavy isotopes (2H, 13C, 15N) and the remainder of the protein with natural isotopic abundance, and the other one with only the C‐terminal segment isotopically labeled. Kinetic investigations indicated that isotopic substitution of the N‐terminal segment affected only a physical step of catalysis, whereas the enzyme chemistry was affected by protein motions from the C‐terminal segment. QM/MM studies support the idea that dynamic effects on catalysis mostly originate from the C‐terminal segment. The use of isotope hybrids provides insights into the microscopic mechanism of dynamic coupling, which is difficult to obtain with other studies, and helps define the dynamic networks of intramolecular interactions central to enzyme catalysis. PMID:26079622

  16. Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

    PubMed

    Luk, Louis Y P; Ruiz-Pernía, J Javier; Adesina, Aduragbemi S; Loveridge, E Joel; Tuñón, Iñaki; Moliner, Vincent; Allemann, Rudolf K

    2015-07-27

    Chemical ligation has been used to alter motions in specific regions of dihydrofolate reductase from E. coli and to investigate the effects of localized motional changes on enzyme catalysis. Two isotopic hybrids were prepared; one with the mobile N-terminal segment containing heavy isotopes ((2) H, (13) C, (15) N) and the remainder of the protein with natural isotopic abundance, and the other one with only the C-terminal segment isotopically labeled. Kinetic investigations indicated that isotopic substitution of the N-terminal segment affected only a physical step of catalysis, whereas the enzyme chemistry was affected by protein motions from the C-terminal segment. QM/MM studies support the idea that dynamic effects on catalysis mostly originate from the C-terminal segment. The use of isotope hybrids provides insights into the microscopic mechanism of dynamic coupling, which is difficult to obtain with other studies, and helps define the dynamic networks of intramolecular interactions central to enzyme catalysis.

  17. Radar-based rainfall thresholds for debris flow warning: A review of opportunities, effect of estimation uncertainties, and assessment of key challenges

    NASA Astrophysics Data System (ADS)

    Marra, F.; Nikolopoulos, E.; Borga, M.; Creutin, J. D.

    2013-12-01

    The increasing availability of weather radar precipitation products provides new opportunities to improve upon existing methods for debris flow warning. The aim of this work is to examine how different characteristics of precipitation products, derived either from raingauges or from weather radar, may impact on the identification and use of precipitation thresholds that are used for debris flow warning. Precipitation exhibits space and time variability at all scales leading to high uncertainty in raingauge-based rain estimation. One distinct feature of the precipitation estimation problem for raingauge-based threshold relationship identification and use, is that the triggering precipitation to be estimated at the debris flow location exceeds an actual threshold which is likely not to be exceeded at the measuring raingauges. Recent results has shown that these characteristics may lead to biased precipitation threshold identification and low warning efficiency. Weather radar monitoring represent an interesting alternative for precipitation threshold identification, overcoming the sampling problem of point measurements. However, despite long-standing efforts, radar derived estimates are still affected by considerable uncertainties, particularly in the rough topography terrain typical of debris flows. It is therefore important to understand how uncertainties due to either rainfall sampling (typical of raingauges) or to rainfall estimation (typical of weather radar) propagates through the precipitation threshold identification methodology. Results are presented for a set of 10 high intensity debris-flow triggering storms that impacted the Southern Tyrol Region (Eastern Italian Alps) during the last decade. The region is characterized by rough orography, with elevation ranging from 300 to 4000 m asl, and it is monitored by a raingauge network with an average density of 1/70 km2 and a well calibrated and maintained C-band Doppler radar. High quality radar rainfall

  18. Drivers' eye movements as a function of collision avoidance warning conditions in red light running scenarios.

    PubMed

    Zhang, Yuting; Yan, Xuedong; Li, Xiaomeng; Xue, Qingwan

    2016-11-01

    The intersection collision avoidance warning systems (ICAWSs) have substantial potentials in improving driving performance and reducing the number and severity of intersection collisions, through helping drivers timely detect hazardous conflicting vehicles in precrash scenarios. However, the influences of ICAWS on drivers' visual performance have barely been discussed. This study focuses on exploring the patterns in drivers' eye movements as a function of ICAWS's warning conditions in red light running scenarios based on a driving simulation experiment. Two types of speech warning conditions including warning timings (varied form 2.5s to 5.5s) and directional information (with or without) are examined, and the no-warning condition is the baseline. The results revealed that more subjects would be likely to benefit from the ICWAS under the earlier warning timings. The warning condition of 4.5s ahead of a collision had the best effectiveness in terms of visual performances. Under such a warning timing, drivers had shorter fixation duration and higher frequency of searching for the red light running (RLR) vehicles. Compared to the warning condition without directional information, the directional warning information could capture drivers' attention more efficiently, help driver direct fixations toward the RLR vehicles more quickly and lead to more scanning activities. Compared to female drivers, male drivers had more scanning activities when approaching intersections, detected the RLR vehicles more quickly and were more likely to avoid the RLR collisions. Besides, the experiment results indicated that the female drivers were more inclined to trust the warning information and got more benefits from the RLR-ICAWS in terms of the crash risk reduction rate than male drivers. Finally, the conclusions lead the way toward warning condition design recommendations for improving the effectiveness of the RLR-ICAWSs.

  19. Advanced driver assistance systems: Using multimodal redundant warnings to enhance road safety.

    PubMed

    Biondi, Francesco; Strayer, David L; Rossi, Riccardo; Gastaldi, Massimiliano; Mulatti, Claudio

    2017-01-01

    This study investigated whether multimodal redundant warnings presented by advanced assistance systems reduce brake response times. Warnings presented by assistance systems are designed to assist drivers by informing them that evasive driving maneuvers are needed in order to avoid a potential accident. If these warnings are poorly designed, they may distract drivers, slow their responses, and reduce road safety. In two experiments, participants drove a simulated vehicle equipped with a forward collision avoidance system. Auditory, vibrotactile, and multimodal warnings were presented when the time to collision was shorter than five seconds. The effects of these warnings were investigated with participants performing a concurrent cell phone conversation (Exp. 1) or driving in high-density traffic (Exp. 2). Braking times and subjective workload were measured. Multimodal redundant warnings elicited faster braking reaction times. These warnings were found to be effective even when talking on a cell phone (Exp. 1) or driving in dense traffic (Exp. 2). Multimodal warnings produced higher ratings of urgency, but ratings of frustration did not increase compared to other warnings. Findings obtained in these two experiments are important given that faster braking responses may reduce the potential for a collision.

  20. Is More Better? — Night Vision Enhancement System’s Pedestrian Warning Modes and Older Drivers

    PubMed Central

    Brown, Timothy; He, Yefei; Roe, Cheryl; Schnell, Thomas

    2010-01-01

    Pedestrian fatalities as a result of vehicle collisions are much more likely to happen at night than during day time. Poor visibility due to darkness is believed to be one of the causes for the higher vehicle collision rate at night. Existing studies have shown that night vision enhancement systems (NVES) may improve recognition distance, but may increase drivers’ workload. The use of automatic warnings (AW) may help minimize workload, improve performance, and increase safety. In this study, we used a driving simulator to examine performance differences of a NVES with six different configurations of warning cues, including: visual, auditory, tactile, auditory and visual, tactile and visual, and no warning. Older drivers between the ages of 65 and 74 participated in the study. An analysis based on the distance to pedestrian threat at the onset of braking response revealed that tactile and auditory warnings performed the best, while visual warnings performed the worst. When tactile or auditory warnings were presented in combination with visual warning, their effectiveness decreased. This result demonstrated that, contrary to general sense regarding warning systems, multi-modal warnings involving visual cues degraded the effectiveness of NVES for older drivers. PMID:21050616

  1. Advanced driver assistance systems: Using multimodal redundant warnings to enhance road safety.

    PubMed

    Biondi, Francesco; Strayer, David L; Rossi, Riccardo; Gastaldi, Massimiliano; Mulatti, Claudio

    2017-01-01

    This study investigated whether multimodal redundant warnings presented by advanced assistance systems reduce brake response times. Warnings presented by assistance systems are designed to assist drivers by informing them that evasive driving maneuvers are needed in order to avoid a potential accident. If these warnings are poorly designed, they may distract drivers, slow their responses, and reduce road safety. In two experiments, participants drove a simulated vehicle equipped with a forward collision avoidance system. Auditory, vibrotactile, and multimodal warnings were presented when the time to collision was shorter than five seconds. The effects of these warnings were investigated with participants performing a concurrent cell phone conversation (Exp. 1) or driving in high-density traffic (Exp. 2). Braking times and subjective workload were measured. Multimodal redundant warnings elicited faster braking reaction times. These warnings were found to be effective even when talking on a cell phone (Exp. 1) or driving in dense traffic (Exp. 2). Multimodal warnings produced higher ratings of urgency, but ratings of frustration did not increase compared to other warnings. Findings obtained in these two experiments are important given that faster braking responses may reduce the potential for a collision. PMID:27633218

  2. Effectiveness of Front-Of-Pack Nutrition Labels in French Adults: Results from the NutriNet-Santé Cohort Study

    PubMed Central

    Ducrot, Pauline; Méjean, Caroline; Julia, Chantal; Kesse-Guyot, Emmanuelle; Touvier, Mathilde; Fezeu, Léopold; Hercberg, Serge; Péneau, Sandrine

    2015-01-01

    Background To date, no consensus has emerged on the most appropriate front-of-pack (FOP) nutrition label to help consumers in making informed choices. We aimed to compare the effectiveness of the label formats currently in use: nutrient-specific, graded and simple summary systems, in a large sample of adults. Methods The FOP label effectiveness was assessed by measuring the label acceptability and understanding among 13,578 participants of the NutriNet-Santé cohort study, representative of the French adult population. Participants were exposed to five conditions, including four FOP labels: Guideline Daily Amounts (GDA), Multiple Traffic Lights (MTL), 5-Color Nutrition Label (5-CNL), Green Tick (Tick), and a “no label” condition. Acceptability was evaluated by several indicators: attractiveness, liking and perceived cognitive workload. Objective understanding was assessed by the percentage of correct answers when ranking three products according to their nutritional quality. Five different product categories were tested: prepared fish dishes, pizzas, dairy products, breakfast cereals, and appetizers. Differences among the label effectiveness were compared with chi-square tests. Results The 5-CNL was viewed as the easiest label to identify and as the one requiring the lowest amount of effort and time to understand. GDA was considered as the least easy to identify and to understand, despite being the most attractive and liked label. All FOP labels were found to be effective in ranking products according to their nutritional quality compared with the “no label” situation, although they showed differing levels of effectiveness (p<0.0001). Globally, the 5-CNL performed best, followed by MTL, GDA and Tick labels. Conclusions The graded 5-CNL label was considered as easy to identify, simple and rapid to understand; it performed well when comparing the products’ nutritional quality. Therefore, it is likely to present advantages in real shopping situations where

  3. Investigating drug repositioning opportunities in FDA drug labels through topic modeling

    PubMed Central

    2012-01-01

    Background Drug repositioning offers an opportunity to revitalize the slowing drug discovery pipeline by finding new uses for currently existing drugs. Our hypothesis is that drugs sharing similar side effect profiles are likely to be effective for the same disease, and thus repositioning opportunities can be identified by finding drug pairs with similar side effects documented in U.S. Food and Drug Administration (FDA) approved drug labels. The safety information in the drug labels is usually obtained in the clinical trial and augmented with the observations in the post-market use of the drug. Therefore, our drug repositioning approach can take the advantage of more comprehensive safety information comparing with conventional de novo approach. Method A probabilistic topic model was constructed based on the terms in the Medical Dictionary for Regulatory Activities (MedDRA) that appeared in the Boxed Warning, Warnings and Precautions, and Adverse Reactions sections of the labels of 870 drugs. Fifty-two unique topics, each containing a set of terms, were identified by using topic modeling. The resulting probabilistic topic associations were used to measure the distance (similarity) between drugs. The success of the proposed model was evaluated by comparing a drug and its nearest neighbor (i.e., a drug pair) for common indications found in the Indications and Usage Section of the drug labels. Results Given a drug with more than three indications, the model yielded a 75% recall, meaning 75% of drug pairs shared one or more common indications. This is significantly higher than the 22% recall rate achieved by random selection. Additionally, the recall rate grows rapidly as the number of drug indications increases and reaches 84% for drugs with 11 indications. The analysis also demonstrated that 65 drugs with a Boxed Warning, which indicates significant risk of serious and possibly life-threatening adverse effects, might be replaced with safer alternatives that do not

  4. Saturation transfer electron spin resonance of Ca2(+)-ATPase covalently spin-labeled with beta-substituted vinyl ketone- and maleimide-nitroxide derivatives. Effects of segmental motion and labeling levels.

    PubMed Central

    Horváth, L I; Dux, L; Hankovszky, H O; Hideg, K; Marsh, D

    1990-01-01

    The Ca2(+)-ATPase in native sarcoplasmic reticulum membranes was selectively spin-labeled for saturation transfer electron spin resonance (ESR) studies by prelabeling with N-ethylmaleimide and by using low label/protein ratios. Results with the nitroxide derivative of the standard sulphydryl-modifying reagent, maleimide, were compared with a series of six novel nitroxide beta-substituted vinyl aryl ketone derivatives which differed (with two exceptions) in the substituent at the ketone position. The two exceptions had a different electron withdrawing group at the alpha-carbon, to enhance further the electrophilic character of the beta-carbon. Although differing in their reactivity, all the conjugated unsaturated ketone nitroxide derivatives displayed saturation transfer ESR spectra indicative of much slower motion than did the maleimide derivative. The saturation transfer ESR spectra of maleimide-labeled Ca2(+)-ATPase therefore most likely contain substantial contributions from segmental motion of the labeled group. The effects of the level of spin labeling were also investigated. With increasing degree of spin label incorporation, the linewidths of the conventional ESR spectrum progressively increased and the intensity of the saturation transfer spectrum dropped dramatically, as a result of increasing spin-spin interactions. The hyperfine splittings of the conventional spectrum and the outer lineheight ratios of the saturation transfer spectrum remained relatively unchanged. Extrapolation back to zero labeling level yielded comparable values for the effective rotational correlation times deduced from the saturation transfer spectrum intensities and from the lineheight ratios, for the vinyl ketone label. For the maleimide label the extrapolated values from the integral are significantly lower than those from the lineheight ratios, probably because of the segmental motion. Comparison is made of the effective rotational correlation time for the vinyl ketone label

  5. Supplementing Menu Labeling With Calorie Recommendations to Test for Facilitation Effects

    PubMed Central

    Wisdom, Jessica; Wansink, Brian; Loewenstein, George

    2013-01-01

    Objectives. We examined the effect on food purchases of adding recommended calorie intake per day or per meal to the mandated calorie information posted on chain restaurant menus. Methods. Before and after New York City implemented calorie posting on chain restaurant menus in 2008, we provided daily, per-meal, or no calorie recommendations to randomized subsets of adult lunchtime customers (n = 1121) entering 2 McDonald’s restaurants, in Manhattan and Brooklyn, and collected receipts and survey responses as they exited. In linear and logistic regressions, with adjustment for gender, race, age, and day, we tested for simple differences in calories consumed and interactions between variables. Results. Posting calorie benchmarks had no direct impact, nor did it moderate the impact of calorie labels on food purchases. The recommendation appeared to promote a slight increase in calorie intake, attributable to increased purchases of higher-calorie entrées. Conclusions. These results do not support the introduction of calorie recommendations as a means of enhancing the impact of posted calorie information or reducing the contribution of restaurant dining to the obesity epidemic. PMID:23865657

  6. 16 CFR 1205.2 - Effective date.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... STANDARD FOR WALK-BEHIND POWER LAWN MOWERS The Standard § 1205.2 Effective date. This standard applies to all rotary walk behind power lawn mowers manufactured after June 30, 1982, except § 1205.6 Warning labels, applies to rotary and reel-type walk-behind power lawn mowers manufactured after December...

  7. 16 CFR 1205.2 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... STANDARD FOR WALK-BEHIND POWER LAWN MOWERS The Standard § 1205.2 Effective date. This standard applies to all rotary walk behind power lawn mowers manufactured after June 30, 1982, except § 1205.6 Warning labels, applies to rotary and reel-type walk-behind power lawn mowers manufactured after December...

  8. Effects of organizational scheme and labeling on task performance in product-centered and user-centered retail Web sites.

    PubMed

    Resnick, Marc L; Sanchez, Julian

    2004-01-01

    As companies increase the quantity of information they provide through their Web sites, it is critical that content is structured with an appropriate architecture. However, resource constraints often limit the ability of companies to apply all Web design principles completely. This study quantifies the effects of two major information architecture principles in a controlled study that isolates the incremental effects of organizational scheme and labeling on user performance and satisfaction. Sixty participants with a wide range of Internet and on-line shopping experience were recruited to complete a series of shopping tasks on a prototype retail shopping Web site. User-centered labels provided a significant benefit in performance and satisfaction over labels obtained through company-centered methods. User-centered organization did not result in improved performance except when the label quality was poor. Significant interactions suggest specific guidelines for allocating resources in Web site design. Applications of this research include the design of Web sites for any commercial application, particularly E-commerce. PMID:15151158

  9. Regional Warning Center Sweden

    NASA Astrophysics Data System (ADS)

    Lundstedt, Henrik

    RWC-Sweden is operated by the Lund division of the Swedish Institute of Space Physics located at IDEON, a Science Research Technology Park. The Institute of Technology of Lund and Lund University are just adjacent to IDEON. This creates a lot of synergy effects. Copenhagen, with the Danish National Space Center DNSC), and Atmosphere Space Research Division of Danish Meteorological Institute (DMI), is 45 min away via the bridge. The new LOIS Space Centre is located two hours away by car, north of Lund and just outside V¨xj¨. The IRF Lund a o division is aiming at becoming a "Solar and Space Weather Center". We focus on solar magnetic activity, its influence on climate and on space weather effects such the effect of geomagnetically induced currents (GIC). Basic research: A PostDoc position on "Solar Magnetic Activity: Topology and Predictions has recently been created. Research is carried on to improve predictions of solar magnetic activity. Preparations for using upcoming SDO vector magnetic fields are ongoing. Predictions: RWC-Sweden offers real-time forecasts of space weather and space weather effects based on neural networks. We participated in the NASA/NOAA Cycle 24 Prediction Panel. We have also participated in several ESA/EU solar-climate projects New observation facilities: Distributed, wide-area radio facility (LOIS) for solar (and other space physics) observations and a guest prof: Radio facility about 200 km distant, outside V¨xj¨ (Sm˚ a o aland), in Ronneby (Blekinge) and Lund (Sk˚ ane) is planned to be used for tracking of CMEs and basic solar physics studies of the corona. The LOIS station outside V¨xj¨ has a o been up and running for the past three years. Bo Thidé has joined the Lund division e as a guest prof. A new magnetometer at Risinge LOIS station has been installed an calibrated and expected to be operational in March, 2008.

  10. Nutrition Labeling

    NASA Astrophysics Data System (ADS)

    Metzger, Lloyd E.

    Nutrition labeling regulations differ in countries around the world. The focus of this chapter is on nutrition labeling regulations in the USA, as specified by the Food and Drug Administration (FDA) and the Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA). A major reason for analyzing the chemical components of foods in the USA is nutrition labeling regulations. Nutrition label information is not only legally required in many countries, but also is of increasing importance to consumers as they focus more on health and wellness.

  11. 21 CFR 809.10 - Labeling for in vitro diagnostic products.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... contained in 16 CFR part 1500 and any other warnings appropriate to the hazard presented by the product; and... immediate containers too small or otherwise unable to accommodate a label with sufficient space to bear all... established in the regulations contained in 16 CFR part 1500 and any other warnings appropriate to the...

  12. 21 CFR 809.10 - Labeling for in vitro diagnostic products.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... contained in 16 CFR part 1500 and any other warnings appropriate to the hazard presented by the product; and... immediate containers too small or otherwise unable to accommodate a label with sufficient space to bear all... established in the regulations contained in 16 CFR part 1500 and any other warnings appropriate to the...

  13. The Financial Benefit of Early Flood Warnings in Europe

    NASA Astrophysics Data System (ADS)

    Pappenberger, Florian; Cloke, Hannah L.; Wetterhall, Fredrik; Parker, Dennis J.; Richardson, David; Thielen, Jutta

    2015-04-01

    Effective disaster risk management relies on science based solutions to close the gap between prevention and preparedness measures. The outcome of consultations on the UNIDSR post-2015 framework for disaster risk reduction highlight the need for cross-border early warning systems to strengthen the preparedness phases of disaster risk management in order to save people's lives and property and reduce the overall impact of severe events. In particular, continental and global scale flood forecasting systems provide vital information to various decision makers with which early warnings of floods can be made. Here the potential monetary benefits of early flood warnings using the example of the European Flood Awareness System (EFAS) are calculated based on pan-European Flood damage data and calculations of potential flood damage reductions. The benefits are of the order of 400 Euro for every 1 Euro invested. Because of the uncertainties which accompany the calculation, a large sensitivity analysis is performed in order to develop an envelope of possible financial benefits. Current EFAS system skill is compared against perfect forecasts to demonstrate the importance of further improving the skill of the forecasts. Improving the response to warnings is also essential in reaping the benefits of flood early warnings.

  14. Towards a nationwide Early Warning System in Romania

    NASA Astrophysics Data System (ADS)

    Marmureanu, A.; Ionescu, C.; Manea, L.

    2012-04-01

    The need to use early warning methods to reduce natural risks in modern societies is related to their unprecedented dependence upon technology. The strong deep events originating from Vrancea-Romania (Mw =7.5) area and shallow events originating from Banat-Romania or Shabla-Bulgaria areas can generate destructive effects in Romania and neighbor countries, and may seriously affect high risk manmade structures. EWS for deep Vrancea earthquakes uses the time interval (28-32 sec.) between the moment when the earthquake is detected by the local seismic network installed in the epicenter area (Vrancea) and the arrival time of the seismic waves in the protected area (Bucharest) to send earthquake warning to users. For the shallow events several methodologies to rapidly estimate earthquake magnitude are under testing. NIEP developed an early warning system that is able to evaluate rapidly earthquake magnitude after detection in the epicenter. In the last years, NIEP upgraded its seismic network in order to cover better the seismic zones of Romania. The early warning system consists of seismic stations that allow rapid communication of data, several software modules developed at NIEP and a communication network. The system allows estimation of earthquake magnitude and permits to send earthquake alarm very fast to users. The early warning software modules minimize communication latencies present in other communication protocols in order to have a rapid magnitude determination. This software was developed by NIEP and is running in present at our institute in real time.

  15. Conspicuity, memorability, comprehension, and priming in road hazard warning signs.

    PubMed

    Charlton, Samuel G

    2006-05-01

    This study assessed driver reactions to 16 road hazard warning signs of various formats by projecting life-sized video of road scenes to drivers in a driving simulator. A range of measures, including attentional and search conspicuity, implicit and explicit recognition, dynamic and static comprehension, and sign priming were collected. Of the signs tested, road works and school warning signs were most often detected, remembered, and understood. Slippery surface warnings were associated with some of the lowest detection and comprehension rates. The effectiveness of the different formats depended on the type of hazard sign. In the case of road works warnings, a flashing variable message format was only slightly more conspicuous than the large dimension format, equal in comprehensibility, and perhaps somewhat worse in terms of memorability. For the school warnings, however, the flashing variable message format appeared to convey a greater sense of potential hazard, produced superior search conspicuity and priming, and was equal in terms of memorability and comprehensibility. The range of measures worked well as a whole with the two measures of conspicuity and the measure of static comprehension showing the greatest consistency.

  16. An early warning technique.

    PubMed

    MacStravic, R S

    1986-01-01

    During budget preparation, forecasts of inpatient utilization for the coming year play a pivotal role. Use of ancillary services and nursing care is a function of the number of admissions and patient days expected. With DRG payment, the average length of stay has decreased, as has the amount of ancillary service per case. Utilization experience should be reviewed after the budget utilization forecast is made. If it is likely to be lower than the forecast, management should respond as soon as possible. The earlier these responses are made, the more effective they are. PMID:10275078

  17. Licorice abuse: time to send a warning message

    PubMed Central

    Komarova, Irina; El-Ghonemi, Mohamed; Fathy, Ahmed; Rashad, Rania; Abdelmalak, Hany D.; Yerramadha, Muralidhar Reddy; Ali, Yaseen; Helal, Engy; Camporesi, Enrico M.

    2012-01-01

    Licorice extract has always been recognized as a sweetener and a thirst quencher. Its nutritive value is overrated by many who consume significant amounts and are prone to complications. Glycyrrhetic acid, the active metabolite in licorice, inhibits the enzyme 11-ß-hydroxysteroid dehydrogenase enzyme type 2 with a resultant cortisol-induced mineralocorticoid effect and the tendency towards the elevation of sodium and reduction of potassium levels. This aldosterone-like action is the fundamental basis for understanding its health benefits and the wide spectrum of adverse effects. Herein, we present a comprehensive review of licorice along with the reported complications related to excess intake. Despite its apparent use in a few clinical scenarios, the daily consumption of licorice is never justified because its benefits are minor compared to the adverse outcomes of chronic consumption. The review highlights the importance of investigating the dietary habits and herbal remedies which are being used worldwide on cultural and habitual bases rather than reliable scientific evidence. Licorice is a US Food and Drug Administration (FDA) approved food supplement used in many products without precise regulations to prevent toxicity. Increased awareness among the public is required through TV commercials, newspapers, internet sites, magazines and product labels regarding the upper limit of ingestion and health hazards associated with excess intake. We hope that this review will serve as a warning message that should be transmitted from physicians to patients to avoid excessive licorice intake as well as a message to the FDA to start regulating the use of this substance. PMID:23185686

  18. Reducing the negative effects of media exposure on body image: Testing the effectiveness of subvertising and disclaimer labels.

    PubMed

    Frederick, David A; Sandhu, Gaganjyot; Scott, Terri; Akbari, Yasmin

    2016-06-01

    Body image activists have proposed adding disclaimer labels to digitally altered media as a way to promote positive body image. Another approach advocated by activists is to alter advertisements through subvertising (adding social commentary to the image to undermine the message of the advertisement). We examined if body image could be enhanced by attaching Photoshop disclaimers or subvertising to thin-ideal media images of swimsuit models. In Study 1 (N=1268), adult women exposed to disclaimers or subvertising did not report higher body state satisfaction or lower drive for thinness than women exposed to unaltered images. In Study 2 (N=820), adult women who were exposed to disclaimers or subvertising did not report higher state body satisfaction or lower state social appearance comparisons than women exposed to unaltered images or to no images. These results raise questions about the effectiveness of disclaimers and subvertising for promoting body satisfaction. PMID:27085112

  19. Reducing the negative effects of media exposure on body image: Testing the effectiveness of subvertising and disclaimer labels.

    PubMed

    Frederick, David A; Sandhu, Gaganjyot; Scott, Terri; Akbari, Yasmin

    2016-06-01

    Body image activists have proposed adding disclaimer labels to digitally altered media as a way to promote positive body image. Another approach advocated by activists is to alter advertisements through subvertising (adding social commentary to the image to undermine the message of the advertisement). We examined if body image could be enhanced by attaching Photoshop disclaimers or subvertising to thin-ideal media images of swimsuit models. In Study 1 (N=1268), adult women exposed to disclaimers or subvertising did not report higher body state satisfaction or lower drive for thinness than women exposed to unaltered images. In Study 2 (N=820), adult women who were exposed to disclaimers or subvertising did not report higher state body satisfaction or lower state social appearance comparisons than women exposed to unaltered images or to no images. These results raise questions about the effectiveness of disclaimers and subvertising for promoting body satisfaction.

  20. 76 FR 2268 - Viruses, Serums, Toxins, and Analogous Products; Packaging and Labeling

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ... storage temperature recommended in labeling for veterinary biologics; require vaccination and... adequate instructions for the proper use of the product, including vaccination schedules, warnings, and...)(5) to clarify that ``full instructions for the proper use of the product'' refers to...