Spatial pattern formation of coastal vegetation in response to external gradients and positive feedbacks affecting soil porewater salinity: A model study

USGS Publications Warehouse

Jiang, J.; DeAngelis, D.L.; Smith, T. J.; Teh, S.Y.; Koh, H. L.

2012-01-01

Coastal vegetation of South Florida typically comprises salinity-tolerant mangroves bordering salinity-intolerant hardwood hammocks and fresh water marshes. Two primary ecological factors appear to influence the maintenance of mangrove/hammock ecotones against changes that might occur due to disturbances. One of these is a gradient in one or more environmental factors. The other is the action of positive feedback mechanisms, in which each vegetation community influences its local environment to favor itself, reinforcing the boundary between communities. The relative contributions of these two factors, however, can be hard to discern. A spatially explicit individual-based model of vegetation, coupled with a model of soil hydrology and salinity dynamics is presented here to simulate mangrove/hammock ecotones in the coastal margin habitats of South Florida. The model simulation results indicate that an environmental gradient of salinity, caused by tidal flux, is the key factor separating vegetation communities, while positive feedback involving the different interaction of each vegetation type with the vadose zone salinity increases the sharpness of boundaries, and maintains the ecological resilience of mangrove/hammock ecotones against small disturbances. Investigation of effects of precipitation on positive feedback indicates that the dry season, with its low precipitation, is the period of strongest positive feedback. ?? 2011 Springer Science+Business Media B.V. (outside the USA).

The ecology of hydric hammocks: a community profile

USGS Publications Warehouse

Vince, Susan W.; Humphrey, Stephen R.; Simons, Robert W.

1989-01-01

This community profile is one in a series of Fish and Wildlife Service publications compiled to provide a state-of-knowledge synthesis of scientific information and literature on various coastal habitats. The subject of this profile is the hydric hammock, a distinctive type of forested wetland occurring at low elevations along the gulf coast of Florida from Aripeka to St. Marks and at various inland sites in Florida. Relatively little research has been conducted in hydric hammocks, and no thorough effort has been made previously to define this community. Consequently, no consensus has existed about the extent and nature of this community; some published works and active researchers have differed in their judgments about it; and the entity sometimes is ignored and often is lumped with other types of mixed hardwood forests. The purpose of this profile is to establish or clarify an identification and understanding of the hydric-hammock community. Information for the profile was gathered from published and unpublished literature, from persona 1 communication with many technical experts, and from our own fie 1 d experience. The profile includes some new data gathered in the field for the purpose of defining this community. It is hoped that the content and format of the profile will be useful to a broad spectrum of users, including other scientists, students, resource managers and planners, teachers, and interested citizens. The profile includes structural and functional aspects of the community: its physical setting, plant and animal composition and dynamics, interactions of its flora and fauna, and its relationships with other communities.

Partial hammock valve: surgical repair in adulthood.

PubMed

Aramendi, José I; Rodríguez, Miguel A; Voces, Roberto; Pérez, Pedro; Rodrigo, David

2006-09-01

We describe a forme frustrée of hammock valve involving only the posterior mitral leaflet. Three adult patients were referred to surgery with the diagnosis of severe mitral regurgitation due to fibrosis of the posterior mitral leaflet. The final diagnosis was done intraoperatively. In all of them the posterior leaflet was attached to some accessory papillary muscles arranged en palisade, with three to four fused muscle heads producing restrictive leaflet motion in systole. Repair consisted in division of the papillary muscles, patch augmentation, and ring annuloplasty. This previously unreported lesion is congenital but manifests itself in adulthood.

Competition between hardwood hammocks and mangroves

USGS Publications Warehouse

Sternberg, L.D.S.L.; Teh, S.Y.; Ewe, S.M.L.; Miralles-Wilhelm, F.; DeAngelis, D.L.

2007-01-01

The boundaries between mangroves and freshwater hammocks in coastal ecotones of South Florida are sharp. Further, previous studies indicate that there is a discontinuity in plant predawn water potentials, with woody plants either showing predawn water potentials reflecting exposure to saline water or exposure to freshwater. This abrupt concurrent change in community type and plant water status suggests that there might be feedback dynamics between vegetation and salinity. A model examining the salinity of the aerated zone of soil overlying a saline body of water, known as the vadose layer, as a function of precipitation, evaporation and plant water uptake is presented here. The model predicts that mixtures of saline and freshwater vegetative species represent unstable states. Depending on the initial vegetation composition, subsequent vegetative change will lead either to patches of mangrove coverage having a high salinity vadose zone or to freshwater hammock coverage having a low salinity vadose zone. Complete or nearly complete coverage by either freshwater or saltwater vegetation represents two stable steady-state points. This model can explain many of the previous observations of vegetation patterns in coastal South Florida as well as observations on the dynamics of vegetation shifts caused by sea level rise and climate change. ?? 2007 Springer Science+Business Media, LLC.

KENNEDY SPACE CENTER, FLA. - Wildflowers resembling petunias stand out against the deep green of the marsh foliage at KSC, which shares a boundary with the National Merritt Island Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks.

NASA Image and Video Library

2003-07-29

KENNEDY SPACE CENTER, FLA. - Wildflowers resembling petunias stand out against the deep green of the marsh foliage at KSC, which shares a boundary with the National Merritt Island Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks.

Bistability of mangrove forests and competition with freshwater plants

USGS Publications Warehouse

Jiang, Jiang; Fuller, Douglas O; Teh, Su Yean; Zhai, Lu; Koh, Hock Lye; DeAngelis, Donald L.; Sternberg, L.D.S.L.

2015-01-01

Halophytic communities such as mangrove forests and buttonwood hammocks tend to border freshwater plant communities as sharp ecotones. Most studies attribute this purely to underlying physical templates, such as groundwater salinity gradients caused by tidal flux and topography. However, a few recent studies hypothesize that self-reinforcing feedback between vegetation and vadose zone salinity are also involved and create a bistable situation in which either halophytic dominated habitat or freshwater plant communities may dominate as alternative stable states. Here, we revisit the bistability hypothesis and demonstrate the mechanisms that result in bistability. We demonstrate with remote sensing imagery the sharp boundaries between freshwater hardwood hammock communities in southern Florida and halophytic communities such as buttonwood hammocks and mangroves. We further document from the literature how transpiration of mangroves and freshwater plants respond differently to vadose zone salinity, thus altering the salinity through feedback. Using mathematical models, we show how the self-reinforcing feedback, together with physical template, controls the ecotones between halophytic and freshwater communities. Regions of bistability along environmental gradients of salinity have the potential for large-scale vegetation shifts following pulse disturbances such as hurricane tidal surges in Florida, or tsunamis in other regions. The size of the region of bistability can be large for low-lying coastal habitat due to the saline water table, which extends inland due to salinity intrusion. We suggest coupling ecological and hydrologic processes as a framework for future studies.

A simulation model for projecting changes in salinity concentrations and species dominance in the coastal margin habitats of the Everglades

USGS Publications Warehouse

Teh, S.Y.; DeAngelis, D.L.; Sternberg, L.D.S.L.; Miralles-Wilhelm, F. R.; Smith, T.J.; Koh, H. L.

2008-01-01

Sharp boundaries typically separate the salinity tolerant mangroves from the salinity intolerant hardwood hammock species, which occupy the similar geographical areas of southern Florida. Evidence of strong feedback between tree community-type and the salinity of the unsaturated (vadose) zone of the soil suggests that a severe disturbance that significantly tilts the salinity in the vadose zone might cause a shift from one vegetation type to the other. In this study, a model based upon the feedback dynamics between vegetation and salinity of the vadose zone of the soil was used to take account of storm surge events to investigate the mechanisms that by which this large-scale disturbance could affect the spatial pattern of hardwood hammocks and mangroves. Model simulation results indicated that a heavy storm surge that completely saturated the vadose zone at 30 ppt for 1 day could lead to a regime shift in which there is domination by mangroves of areas previously dominated by hardwood hammocks. Lighter storm surges that saturated the vadose zone at less than 7 ppt did not cause vegetation shifts. Investigations of model sensitivity analysis indicated that the thickness of the vadose zone, coupled with precipitation, influenced the residence time of high salinity in the vadose zone and therefore determined the rate of mangrove domination. The model was developed for a southern Florida coastal ecosystem, but its applicability may be much broader. ?? 2008 Elsevier B.V. All rights reserved.

Registration of 'hammock' centipedegrass.

USDA-ARS?s Scientific Manuscript database

‘Hammock’ (Reg. No. ________, PI 652949) centipedegrass [Eremochloa ophiuroides (Munro) Hack] was developed at the Everglades Research and Education Center, IFAS, University of Florida, Belle Glade, FL and initially approved for release in 2006. A plant patent was filed in 2008 with Plant Patent PP...

Community-randomized trial of lambdacyhalothrin-treated hammock nets for malaria control in Yanomami communities in the Amazon region of Venezuela.

PubMed

Magris, M; Rubio-Palis, Y; Alexander, N; Ruiz, B; Galván, N; Frias, D; Blanco, M; Lines, J

2007-03-01

We conducted a community-randomized controlled trial in an area of moderate malaria transmission in the Amazon region, southern Venezuela, home of the Yanomami indigenous ethnic group. The aim was to compare the malaria incidence rate in villages with lambdacyhalothrin-treated hammock nets (ITHN) or with placebo-treated hammock nets (PTHN). In both arms of the study, intensive surveillance for early case detection was maintained and prompt malaria treatment was administered. Baseline data were collected before the intervention and a population of around 924 Yanomami was followed for 2 years. Despite the recent introduction of nets in the Yanomami villages and the adverse natural conditions in the area, the nets were accepted enthusiastically by the study population, used conscientiously and looked after carefully. The malaria incidence rate per thousand person-years at risk was 114.6 in the IHTN group and 186.8 in the PTHN group. The adjusted rate ratios indicated that ITHN prevent 56% [IRR: 0.44, 95% confidence interval (CI): 52-59%] of new malaria cases. ITHN reduced the prevalence of parasitaemia by 83% [relative risks (RR): 0.17, 95% CI: 47-100%], according to a cross-sectional survey carried out during the high transmission season. The prevalence of splenomegaly and anaemia was too low to detect any possible reduction as a result of ITHN. The main conclusion of the present study is that ITHN can reduce malaria incidence in the area and it is the most feasible method for malaria control in a forested area where indigenous villages are scattered over a large territory. This is the first community-level epidemiological trial to show that ITHN are highly effective against malaria transmitted by Anopheles darlingi.

Evaluating nest supplementation as a recovery strategy for the endangered rodents of the Florida Keys

USGS Publications Warehouse

Cove, Michael V.; Simons, Theodore R.; Gardner, Beth; Maurer, Andrew S.; O'Connell, Allan F.

2017-01-01

The Key Largo woodrat (Neotoma floridana smalli) and Key Largo cotton mouse (Peromyscus gossypinus allapaticola) are federally endangered subspecies endemic to the tropical hardwood hammocks of Key Largo, Florida. Woodrats are considered generalists in habitat and diet, yet a steady decline in natural stick nests and capture rates over the past several decades suggests that they are limited by the availability of nesting habitat due to habitat loss and fragmentation. The more specialized Key Largo cotton mouse appears to rely on old growth hammock, a habitat type that is rare following past land clearing. In 2004, the U.S. Fish and Wildlife Service started building supplemental nest structures to restore habitat quality and connectivity for these endangered rodents, but nest use requires evaluation. We used camera traps and occupancy models to evaluate the factors influencing woodrat and cotton mouse use of the supplemental nests. We detected woodrats at 65 and cotton mice at 175 of 284 sampled nest structures, with co-occurrence at 38 nests. Woodrat nest use followed a gradient from low nest use in the north to high nest use in the south, which might relate to the proximity of free-ranging domestic cat (Felis catus) colonies in residential developments. Cotton mouse nest use, however, was related positively to mature hammock and related negatively to disturbed areas (e.g. scarified lands). The two species occurred independently of each other. Stick-stacking behavior was observed at supplemental nests and, although it was correlated with detection of woodrats, it was not a strong predictor of their occurrence. We suggest that nest supplementation can be an important tool for species recovery as habitat quality continues to improve with succession.

30 CFR Appendix to Part 253 - List of U.S. Geological Survey Topographic Maps

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Florida (1:24,000 scale): Allanton; Alligator Bay; Anna Maria; Apalachicola; Aripeka; Bayport; Beacon...; Miramar Beach; Myakka River; Naples North; Naples South; Navarre; New Inlet; Niceville; Nutall Rise... Level; Rock Islands; Royal Palm Hammock; Safety Harbor; Saint Joseph Point; Saint Joseph Spit; Saint...

30 CFR Appendix to Part 253 - List of U.S. Geological Survey Topographic Maps

Code of Federal Regulations, 2011 CFR

2011-07-01

...; Tustin; Venice; Ventura; White Ledge Peak. Florida (1:24,000 scale): Allanton; Alligator Bay; Anna Maria...; Navarre; New Inlet; Niceville; Nutall Rise; Ochopee; Okefenokee Slough; Oldsmar; Orange Beach; Oriole...; Punta Gorda SE; Punta Gorda SW; Red Head; Red Level; Rock Islands; Royal Palm Hammock; Safety Harbor...

Astronaut Anna Fisher demonstrates sleep restraints on shuttle

NASA Technical Reports Server (NTRS)

1984-01-01

Astronaut Anna L. Fisher demonstrates the versatility of shuttle sleep restraints to accommodate the preference of crewmembers as she appears to have configured hers in a horizontal hammock mode. Stowage lockers, one of the middeck walls, another sleep restraint, a jury-rigged foot and hand restraint are among other items in the frame.

Potential Natural Vegetation Group: Palmetto Prairie

Treesearch

Kenneth W. Outcalt

2004-01-01

Palmetto prairie, also called dry prairie, is a mostly treeless grass dominated community that occupies broad flat regions where fire is very frequent because there are no major natural fire barriers. Interspersed throughout the community are areas occupied by wet prairie, ephemeral depression ponds, marshes, flatwoods, and mesic hammocks. Soils are sandy, poorly to...

Anatomical grades of nerve sparing: a risk-stratified approach to neural-hammock sparing during robot-assisted radical prostatectomy (RARP).

PubMed

Tewari, Ashutosh K; Srivastava, Abhishek; Huang, Michael W; Robinson, Brian D; Shevchuk, Maria M; Durand, Matthieu; Sooriakumaran, Prasanna; Grover, Sonal; Yadav, Rajiv; Mishra, Nishant; Mohan, Sanjay; Brooks, Danielle C; Shaikh, Nusrat; Khanna, Abhinav; Leung, Robert

2011-09-01

• To report the potency and oncological outcomes of patients undergoing robot-assisted radical prostatectomy (RARP) using a risk-stratified approach based on layers of periprostatic fascial dissection. • We also describe the surgical technique of complete hammock preservation or nerve sparing grade 1. • This is a retrospective study of 2317 patients who had robotic prostatectomy by a single surgeon at a single institution between January 2005 and June 2010. • Included patients were those with ≥ 1 year of follow-up and who were potent preoperatively, defined as having a sexual health inventory for men (SHIM) questionnaire score of >21; thus, the final number of patients in the study cohort was 1263. • Patients were categorized pre-operatively by a risk-stratified approach into risk grades 1-4, where risk grade 1 patients received nerve-sparing grade 1 or complete hammock preservation and so on for risk grades 2-4, as long as intraoperative findings permitted the planned nerve sparing. • We considered return to sexual function post-operatively by two criteria: i) ability to have successful intercourse (score of ≥ 4 on question 2 of the SHIM) and ii) SHIM >21 or return to baseline sexual function. • There was a significant difference across different NS grades in terms of the percentages of patients who had intercourse and returned to baseline sexual function (P < 0.001), with those that underwent NS grade 1 having the highest rates (90.9% and 81.7%) as compared to NS grades 2 (81.4% and 74.3%), 3 (73.5% and 66.1%), and 4 (62% and 54.5%). • The overall positive surgical margin (PSM) rates for patients with NS grades 1, 2, 3, and 4 were 9.9%, 8.1%, 7.2%, and 8.7%, respectively (P = 0.636). • The extraprostatic extension rates were 11.6%, 14.3%, 29.3%, and 36.2%, respectively (P < 0.001). • Similarly, in patients younger than 60, intercourse and return to baseline sexual function rates were 94.9% and 84.3% for NS grade 1 as compared to 85.5% and 77.2% for NS grades 2, 76.9% and 69% for NS grades 3, and 64.8% and 57.7% for NS Grade 4 (P < 0.001). • The risk-stratified approach and anatomical technique of neural-hammock sparing described in the present manuscript was effective in improving potency outcomes of patients without compromising cancer control. • Patients with greater degrees of NS had higher rates of intercourse and return to baseline sexual function without an increase in PSM rates. © 2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL.

Installation Restoration Program. Preliminary Assessment: 115th Tactical Control Squadron, Hall Air National Guard Station, Alabama Air National Guard, Dothan, Alabama.

DTIC Science & Technology

1991-02-01

Department of Agriculture (USDA): Soil Conservation Service, February 1968). Houston County is characterized by a warm and humid climate that borders...Figur I..,1 PhUTogrpER Map. of theAre 111-2 3. EXPLANATION - Residuum -~ l Citronelle Formation Catahouia Sandstone Paynes Hammock 0 Oligocene

KSC-03PD-2200

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. Wildflowers resembling petunias stand out against the deep green of the marsh foliage at KSC, which shares a boundary with the National Merritt Island Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks.

Vestibular Stimulation and Development of the Small Premature Infant.

ERIC Educational Resources Information Center

Neal, Mary V.

This study was designed to explore the effects of vestibular stimulation on the developmental behavior, respiratory functioning, weight and length gains, and morbidity and mortality rates of premature infants. A total of 20 infants participated in this study in 4 groups of 5 infants each. Group A infants were placed in a motorized hammock within…

KSC-2009-1012

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. -- Morning light sculpts a cactus on the roadside at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jack Pfaller

46 CFR 7.80 - Tybee Island, GA to St. Simons Island, GA.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Tybee Island south of the entrance to Buck Hammock Creek. (b) A line drawn from the southernmost... 46 Shipping 1 2011-10-01 2011-10-01 false Tybee Island, GA to St. Simons Island, GA. 7.80 Section... BOUNDARY LINES Atlantic Coast § 7.80 Tybee Island, GA to St. Simons Island, GA. (a) A line drawn from the...

46 CFR 7.80 - Tybee Island, GA to St. Simons Island, GA.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Tybee Island south of the entrance to Buck Hammock Creek. (b) A line drawn from the southernmost... 46 Shipping 1 2012-10-01 2012-10-01 false Tybee Island, GA to St. Simons Island, GA. 7.80 Section... BOUNDARY LINES Atlantic Coast § 7.80 Tybee Island, GA to St. Simons Island, GA. (a) A line drawn from the...

46 CFR 7.80 - Tybee Island, GA to St. Simons Island, GA.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Tybee Island south of the entrance to Buck Hammock Creek. (b) A line drawn from the southernmost... 46 Shipping 1 2014-10-01 2014-10-01 false Tybee Island, GA to St. Simons Island, GA. 7.80 Section... BOUNDARY LINES Atlantic Coast § 7.80 Tybee Island, GA to St. Simons Island, GA. (a) A line drawn from the...

46 CFR 7.80 - Tybee Island, GA to St. Simons Island, GA.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Tybee Island south of the entrance to Buck Hammock Creek. (b) A line drawn from the southernmost... 46 Shipping 1 2013-10-01 2013-10-01 false Tybee Island, GA to St. Simons Island, GA. 7.80 Section... BOUNDARY LINES Atlantic Coast § 7.80 Tybee Island, GA to St. Simons Island, GA. (a) A line drawn from the...

Effects of land use on surface-water quality in the East Everglades, Dade County, Florida

USGS Publications Warehouse

Waller, Bradley G.

1982-01-01

Water-quality characteristics were determined at five developed areas in the East Everglades, Dade County, Florida, during the 1978 wet season (June through October). These areas are designated as: Coopertown; Chekika Hammock State Park; residential area; rock-plowed tomato field; and Cracker Jack Slough agricultural area. Data from the developed areas were compared with data from four baseline sites in undeveloped areas to determine the effects of land use on the surface-water quality. The rock-plowed tomato field was the only area where surface-water quality was affected. Water quality at this field is affected by agricultural activities and chemical applications as indicated by increased concentrations of orthophosphate, organic nitrogen, organic carbon, copper, manganese, mercury, and potassium. The remaining four areas of land use had water-quality characteristics typical of baseline sites in nearby Northeast Shark River Slough or Taylor Slough. Chemical analyses of soil indicated chlorinated-hydrocarbon insecticide residues at Coopertown and the two agricultural areas, Cracker Jack Slough and the rock-plowed tomato field. Trace elements in concentrations greater than base level occurred at both agricultural areas (manganese), Chekika Hammock State Park (manganese), and at Coopertown (lead and zinc). (USGS)

KSC-08pd4101

NASA Image and Video Library

2008-12-19

CAPE CANAVERAL, Fla. -- Roseate spoonbills and white ibis search the water for food at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Tim Jacobs

KSC-2009-1011

NASA Image and Video Library

2009-01-05

CAPE CANAVERAL, Fla. – Sunrise casts an orange glow over the wooded landscape surrounding NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jack Pfaller

KSC-2009-1009

NASA Image and Video Library

2009-01-05

CAPE CANAVERAL, Fla. -- Fog blankets the woods near a road in the Merritt Island National Wildlife Refuge at NASA's Kennedy Space Center in Florida. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jack Pfaller

Fast Ss-Ilm a Computationally Efficient Algorithm to Discover Socially Important Locations

NASA Astrophysics Data System (ADS)

Dokuz, A. S.; Celik, M.

2017-11-01

Socially important locations are places which are frequently visited by social media users in their social media lifetime. Discovering socially important locations provide several valuable information about user behaviours on social media networking sites. However, discovering socially important locations are challenging due to data volume and dimensions, spatial and temporal calculations, location sparseness in social media datasets, and inefficiency of current algorithms. In the literature, several studies are conducted to discover important locations, however, the proposed approaches do not work in computationally efficient manner. In this study, we propose Fast SS-ILM algorithm by modifying the algorithm of SS-ILM to mine socially important locations efficiently. Experimental results show that proposed Fast SS-ILM algorithm decreases execution time of socially important locations discovery process up to 20 %.

KSC-08pd4103

NASA Image and Video Library

2008-12-19

CAPE CANAVERAL, Fla. -- Great white herons, roseate spoonbills and white ibis search the water for food at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Tim Jacobs

KSC-2009-1010

NASA Image and Video Library

2009-01-05

CAPE CANAVERAL, Fla. – Fog envelops the Cape Canaveral Lighthouse that has graced Cape Canaveral's shore for more than 100 years under the stewardship of the U.S. Air Force. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jack Pfaller

KSC-07pd2534

NASA Image and Video Library

2007-09-23

KENNEDY SPACE CENTER, FLA. -- A moth with unusual markings is captured on the ground at NASA's Kennedy Space Center. Insects are abundant throughout the center as it shares a boundary with the Merritt Island National Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks. Photo credit: NASA/Amanda Diller

KSC-08pd4102

NASA Image and Video Library

2008-12-19

CAPE CANAVERAL, Fla. -- A great white heron joins roseate spoonbills and white ibis searching the water for food at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Tim Jacobs

Optimizing Screening and Risk Assessment for Suicide in the U. S. Military

DTIC Science & Technology

2011-09-01

and OEF ( Kang & Bullman, 2008). Length of tour of duty has also been associated with death by suicide in Vietnam veterans ( Adams , Barton...than were veterans in the other military branches ( Adams et al., 1998). Posttraumatic stress symptoms may also contribute to increased acquired...1995; Levai , Kaplan, Ackerman, & Hammock, 1995; Hiew, 1992). Combat deployment has also been linked to later domestic violence and child

Sensitivity of wetland hydrology to external climate forcing in central Florida

NASA Astrophysics Data System (ADS)

Lammertsma, Emmy I.; Donders, Timme H.; Pearce, Christof; Cremer, Holger; Gaiser, Evelyn E.; Wagner-Cremer, Friederike

2015-11-01

Available proxy records from the Florida peninsula give a varying view on hydrological changes during the late Holocene. Here we evaluate the consistency and sensitivity of local wetland records in relation to hydrological changes over the past 5 ka based on pollen and diatom proxies from peat cores in Highlands Hammock State Park, central Florida. Around 5 cal ka BP, a dynamic floodplain environment is present. Subsequently, a wetland forest establishes, followed by a change to persistent wet conditions between 2.5 and 2.0 ka. Long hydroperiods remain despite gradual succession and basin infilling with maximum wet conditions between 1.3 and 1.0 ka. The wet phase and subsequent strong drying over the last millennium, as indicated by shifts in both pollen and diatom assemblages, can be linked to the early Medieval Warm Period and Little Ice Age, respectively, driven by regionally higher sea-surface temperatures and a temporary northward migration of the Intertropical Convergence Zone. Changes during the 20th century are the result of constructions intended to protect the Highlands Hammock State Park from wildfires. The multiple cores and proxies allow distinguishing local and regional hydrological changes. The peat records reflect relatively subtle climatic changes that are not evident from regional pollen records from lakes.

KSC-08pd3160

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. - A water lily stretches above the water in a canal on NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island Wildlife Nature Refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd3163

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. - A water lily stretches above the water in a canal on NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island Wildlife Nature Refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals. Photo credit: NASA/Dimitri Gerondidakis

KSC-2011-8343

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- A mud hen wades in the shallows of the water's edge at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2012-6253

NASA Image and Video Library

2012-11-15

Roseate spoonbills and other birds gather near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2012-6251

NASA Image and Video Library

2012-11-15

CAPE CANAVERAL, Fla. - Roseate spoonbills and other birds gather near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2012-6256

NASA Image and Video Library

2012-11-15

CAPE CANAVERAL, Fla. - Roseate spoonbills feed in an area near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2012-6252

NASA Image and Video Library

2012-11-15

CAPE CANAVERAL, Fla. - Roseate spoonbills and other birds gather near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2011-8383

NASA Image and Video Library

2011-12-21

CAPE CANAVERAL, Fla. – Northern pintail ducks fill a pond at Black Point Wildlife Drive, part of the Merritt Island National Wildlife Refuge. NASA's Kennedy Space Center shares a boundary with the refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8330

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- An American wigeon cruises through the water in a pond at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8334

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- Male and female northern shovelers swim in a pond at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8340

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a little blue heron wades in the shallows at water's edge. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8331

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- Male and female blue-wing teals walk along the water's edge at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

Factors Associated With Scoliosis in Schoolchildren: a Cross-Sectional Population-Based Study

PubMed Central

Baroni, Marina Pegoraro; Sanchis, Geronimo José Bouzas; de Assis, Sanderson José Costa; dos Santos, Rafael Gomes; Pereira, Silvana Alves; Sousa, Klayton Galante; Lopes, Johnnatas Mikael

2015-01-01

Background The present study aimed to investigate the prevalence of scoliosis and to analyze the factors associated with scoliosis in schoolchildren aged between 7 and 17 years. Methods This is a cross-sectional and quantitative study with stratified random selection of public school students in the city of Santa Cruz, Brazil. The presence of scoliosis was examined, as well as the flexibility of the posterior muscle chain, socioeconomic characteristics, anthropometry, lifestyle habits, sexual maturation, and ergonomics of school furniture. In order to identify factors associated with scoliosis, the variables were divided in biological, socioeconomic, lifestyle, and ergonomic factors, and crude and adjusted prevalence ratios (PRs) were estimated by means of Poisson regression analysis. Results Two hundred and twelve pupils participated in this study (mean age 11.61 years, 58% female). The prevalence of scoliosis was 58.1% (n = 123) and associated with female sex (PR 2.54; 95% CI, 1.33–4.86) and age between 13 and 15 years (PR 5.35; 95% CI, 2.17–13.21). Sleeping in a hammock was inversely associated with scoliosis (PR 0.44; 95% CI, 0.23–0.81). Conclusions Scoliosis seems to be positively associated with female sex and age between 13 and 15 years, whereas the habit of sleeping in a hammock is negatively associated with the onset of scoliosis. PMID:25716134

Mining connected global and local dense subgraphs for bigdata

NASA Astrophysics Data System (ADS)

Wu, Bo; Shen, Haiying

2016-01-01

The problem of discovering connected dense subgraphs of natural graphs is important in data analysis. Discovering dense subgraphs that do not contain denser subgraphs or are not contained in denser subgraphs (called significant dense subgraphs) is also critical for wide-ranging applications. In spite of many works on discovering dense subgraphs, there are no algorithms that can guarantee the connectivity of the returned subgraphs or discover significant dense subgraphs. Hence, in this paper, we define two subgraph discovery problems to discover connected and significant dense subgraphs, propose polynomial-time algorithms and theoretically prove their validity. We also propose an algorithm to further improve the time and space efficiency of our basic algorithm for discovering significant dense subgraphs in big data by taking advantage of the unique features of large natural graphs. In the experiments, we use massive natural graphs to evaluate our algorithms in comparison with previous algorithms. The experimental results show the effectiveness of our algorithms for the two problems and their efficiency. This work is also the first that reveals the physical significance of significant dense subgraphs in natural graphs from different domains.

KSC-2011-8380

NASA Image and Video Library

2011-12-21

CAPE CANAVERAL, Fla. – A glossy ibis searches for food beneath the algae-covered surface of a pond at Black Point Wildlife Drive, part of the Merritt Island National Wildlife Refuge. NASA's Kennedy Space Center shares a boundary with the refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8344

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- Two common gallinules swim through the algae-covered water of a pond at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8342

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- An anhinga stretches its wings out to dry, taking advantage of the Florida sun at NASA's Kennedy Space Center. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2012-6257

NASA Image and Video Library

2012-11-15

CAPE CANAVERAL, Fla. - Roseate spoonbills and other birds leave an area near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2009-2602

NASA Image and Video Library

2009-04-10

CAPE CANAVERAL, Fla. – A thick-bodied alligator moves through shallow water behind the NASA News Center at NASA's Kennedy Space Center in Florida. A protected species, alligators can be spotted in the drainage canals and other waters surrounding Kennedy. The center shares a boundary with the Merritt Island National Wildlife Refuge that includes saltwater estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Ben Smegelsky

KSC-2012-6254

NASA Image and Video Library

2012-11-15

CAPE CANAVERAL, Fla. - A Roseate spoonbill feeds in an area near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2012-6255

NASA Image and Video Library

2012-11-15

CAPE CANAVERAL, Fla. - A Roseate spoonbill and another bird stand in an area near the Central Instrumentation Facility at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Ben Smegelsky

KSC-2009-2864

NASA Image and Video Library

2009-04-20

CAPE CANAVERAL, Fla. –– A great blue heron takes its familiar stance at the edge of the water, watching for fish or frogs, at NASA's Kennedy Space Center in Florida. A frequent sight around Kennedy, this large heron inhabits lakes, ponds, rivers and marshes in a range from Alaska south to Mexico and the West Indies. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. Photo credit: NASA/Dimitri Gerondidakis

State of STEM (SoSTEM) Address

NASA Image and Video Library

2014-01-29

NASA Astronaut Joe Acaba, center, moderates a panel discussion with NASA's 2013 astronaut candidates, from left, Christina M. Hammock, Andrew R. Morgan, Victor J. Glover, Jessica U. Meir, Tyler N. "Nick" Hague, Josh A. Cassada, Anne C. McClain, and, Nicole Aunapu Mann, at the annual White House State of Science, Technology, Engineering, and Math (SoSTEM) address, Wednesday, Jan. 29, 2014, in the South Court Auditorium in the Eisenhower Executive Office Building on the White House complex in Washington. Photo Credit: (NASA/Bill Ingalls)

State of STEM (SoSTEM) Address

NASA Image and Video Library

2014-01-29

A student ask a question to NASA Astronaut Joe Acaba, center, and NASA's 2013 astronaut candidates, from left, Christina M. Hammock, Andrew R. Morgan, Victor J. Glover, Jessica U. Meir, Tyler N. "Nick" Hague, Josh A. Cassada, Anne C. McClain, and, Nicole Aunapu Mann, at the annual White House State of Science, Technology, Engineering, and Math (SoSTEM) address, Wednesday, Jan. 29, 2014, in the South Court Auditorium in the Eisenhower Executive Office Building on the White House complex in Washington. Photo Credit: (NASA/Bill Ingalls)

KSC-2011-8381

NASA Image and Video Library

2011-12-21

CAPE CANAVERAL, Fla. – Several Florida chicken turtles line up to sun themselves atop a concrete structure at Black Point Wildlife Drive, part of the Merritt Island National Wildlife Refuge. NASA's Kennedy Space Center shares a boundary with the refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8384

NASA Image and Video Library

2011-12-21

CAPE CANAVERAL, Fla. – A pair of northern pintail ducks rest on marsh grass in a pond at Black Point Wildlife Drive, part of the Merritt Island National Wildlife Refuge. NASA's Kennedy Space Center shares a boundary with the refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8336

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- A pied-billed grebe creates a small ring of ripples as it swims in a pond at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8335

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a pond hosts a large group of birds including white ibises and bright-pink roseate spoonbills. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8339

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- An American coot stands on a barely submerged branch in a pond at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8333

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- Two blue-wing teals rest in the grass beside one of the many bodies of water at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8341

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- Two white ibises stand in parallel at the edge of a pond at NASA's Kennedy Space Center in Florida. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8338

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- A Florida chicken turtle basks on a sunlit log in one of the many bodies of water at NASA's Kennedy Space Center. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

Men, Salt, Cattle and Battle: The Civil War in Florida (November 1860-July 1865)

DTIC Science & Technology

1992-06-01

M. Yard, captured British schooner Mabel east of Jacksonville, Florida. (CWNC: pg 1-37) 17 U.S.S. Connecticut, Commander Maxwell Woodhull, captured...reported Confederate pickets at Nine-Mile Hammock, on the Orange Springs Road, and at a point four miles from Palatka on the Rice Creek Road; and a...Lieutenant Marshall N. Rice , USA, Thirty-fifth U.S. Colored Troops, USA, en route from Jacksonville to St. Augustine, Florida, captured by three Confederate

KSC-2011-8329

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- A large alligator appears to smile as it rests in marsh grass at NASA's Kennedy Space Center in Florida. Alligators can be spotted in the drainage canals and other waters surrounding Kennedy. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2009-2861

NASA Image and Video Library

2009-04-20

CAPE CANAVERAL, Fla. –– A black-necked stilt searches the shallow water for food at NASA's Kennedy Space Center in Florida. The species inhabits salt marshes and coastal bays in the East, ranging along the Atlantic Coast from Delaware and the Carolinas to northern South America. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Dimitri Gerondidakis

KSC-2009-2599

NASA Image and Video Library

2009-04-10

CAPE CANAVERAL, Fla. – A black-necked stilt skims across the drainage canal behind the NASA News Center at NASA's Kennedy Space Center in Florida. The species inhabits salt marshes and coastal bays in the East, ranging along the Atlantic Coast from Delaware and the Carolinas to northern South America. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Ben Smegelsky

KSC-2009-2862

NASA Image and Video Library

2009-04-20

CAPE CANAVERAL, Fla. –– A black-necked stilt searches the shallow water for food at NASA's Kennedy Space Center in Florida. The species inhabits salt marshes and coastal bays in the East, ranging along the Atlantic Coast from Delaware and the Carolinas to northern South America. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Dimitri Gerondidakis

KSC-2009-2863

NASA Image and Video Library

2009-04-20

CAPE CANAVERAL, Fla. –– A black-necked stilt finds food in the shallow water at NASA's Kennedy Space Center in Florida. The species inhabits salt marshes and coastal bays in the East, ranging along the Atlantic Coast from Delaware and the Carolinas to northern South America. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Dimitri Gerondidakis

KSC-2011-8382

NASA Image and Video Library

2011-12-21

CAPE CANAVERAL, Fla. – Perched on a section of pipe, this snowy egret keeps a wary eye on the photographer on a sunny day at Black Point Wildlife Drive, part of the Merritt Island National Wildlife Refuge. NASA's Kennedy Space Center shares a boundary with the refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8328

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- A large alligator lounges at the water's edge at NASA's Kennedy Space Center in Florida. Alligators can be spotted in the drainage canals and other waters surrounding Kennedy. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2011-8345

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- A brown pelican stands sentinel on a piling in the turn basin at NASA Kennedy Space Center's Launch Complex 39. Launch Pad 39A is visible in the background. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

Efficient discovery of risk patterns in medical data.

PubMed

Li, Jiuyong; Fu, Ada Wai-chee; Fahey, Paul

2009-01-01

This paper studies a problem of efficiently discovering risk patterns in medical data. Risk patterns are defined by a statistical metric, relative risk, which has been widely used in epidemiological research. To avoid fruitless search in the complete exploration of risk patterns, we define optimal risk pattern set to exclude superfluous patterns, i.e. complicated patterns with lower relative risk than their corresponding simpler form patterns. We prove that mining optimal risk pattern sets conforms an anti-monotone property that supports an efficient mining algorithm. We propose an efficient algorithm for mining optimal risk pattern sets based on this property. We also propose a hierarchical structure to present discovered patterns for the easy perusal by domain experts. The proposed approach is compared with two well-known rule discovery methods, decision tree and association rule mining approaches on benchmark data sets and applied to a real world application. The proposed method discovers more and better quality risk patterns than a decision tree approach. The decision tree method is not designed for such applications and is inadequate for pattern exploring. The proposed method does not discover a large number of uninteresting superfluous patterns as an association mining approach does. The proposed method is more efficient than an association rule mining method. A real world case study shows that the method reveals some interesting risk patterns to medical practitioners. The proposed method is an efficient approach to explore risk patterns. It quickly identifies cohorts of patients that are vulnerable to a risk outcome from a large data set. The proposed method is useful for exploratory study on large medical data to generate and refine hypotheses. The method is also useful for designing medical surveillance systems.

Discover CHP

EPA Pesticide Factsheets

Access information about how CHP systems work; their efficiency, environmental, economic, and reliability benefits; the cost and performance characteristics of CHP technologies; and how to calculate CHP efficiency emissions savings.

Efficiency Vermont - Embedding energy efficiency into low-income programs and services

EPA Pesticide Factsheets

Discover the key features, approaches, partners, funding sources, and achievements of the Efficiency Vermont program and how it has been able to reach nearly one-half of the state’s low-income population.

Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists*

PubMed Central

Srivastava, Stuti; Beck, Barbara; Wang, Wei; Czarna, Anna; Holak, Tad A.; Dömling, Alexander

2009-01-01

The protein-protein interaction of p53 and mdm2 is an important anticancer target. The interface, however, is very hydrophobic and naturally results in very hydrophobic antagonists. We used the Orru three component reaction (O-3CR) along with a rapid and efficient, recently discovered amidation reaction to dramatically improve the water solubility of our recently discovered low molecular weight p53/mdm2 antagonists. Arrays of amides were synthesized with improved hydrophilicity and retainment and/or improvement of p53/mdm2 inhibitory activity. PMID:19548636

KSC-2009-2601

NASA Image and Video Library

2009-04-10

CAPE CANAVERAL, Fla. –Black-necked stilts move onto the bank of the Turn Basin behind the NASA News Center at NASA's Kennedy Space Center in Florida. The species inhabits salt marshes and coastal bays in the East, ranging along the Atlantic Coast from Delaware and the Carolinas to northern South America. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Ben Smegelsky

KSC-2014-2527

NASA Image and Video Library

2014-05-08

CAPE CANAVERAL, Fla. -- Snowy egrets hide in the bramble along the water's edge off Schwartz Road at NASA's Kennedy Space Center in Florida. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Daniel Casper

KSC-2014-2525

NASA Image and Video Library

2014-05-08

CAPE CANAVERAL, Fla. -- A tricolored heron walks along the water's edge off Schwartz Road at NASA's Kennedy Space Center in Florida. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Daniel Casper

KSC-08pd4123

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – A roseate spoonbill is feeding on a pond in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. Spoonbills inhabit areas of mangroves such as on the coasts of southern Florida and Texas. These birds feed on shrimp and fish in the shallow water, sweeping their bills from side to side. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4125

NASA Image and Video Library

2008-12-23

CAPE CANAVERAL, Fla. – A yellowleg sandpiper wades in the shallow water of a pond in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. They range through Alaska and Canada, wintering from the southern U.S. to southern South America. They inhabit marshy ponds, lake and river shores and mud flats. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4127

NASA Image and Video Library

2008-12-23

CAPE CANAVERAL, Fla. – A great egret preens its feathers while standing in the shallow water of a pond in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. The breed feeds alone, stalking fish, frogs, snakes and crayfish in shallow water. They inhabit freshwater and salt marshes, marshy ponds and tidal flats. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-2011-8337

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- Several adult and baby wild pigs, in a variety of colors and patterns, graze in a grassy field at NASA's Kennedy Space Center in Florida. The wild pigs have flourished in the environs around Kennedy. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

Dynamic formation and magnetic support of loop or arcade prominences

NASA Technical Reports Server (NTRS)

Vanhoven, Gerard; Mok, Y.; Drake, J. F.

1992-01-01

The results of model dynamic simulations of the formation and support of a narrow prominence at the apex of a coronal magnetic loop or arcade are described. The condensation process proceeds via an initial radiative cooling and pressure drop, and a secondary siphon flow from the dense chromospheric ends. The antibuoyancy effect as the prominence forms causes a bending of a confining magnetic field, which propagates toward the semirigid ends of the magnetic loop. Thus, a wide magnetic 'hammock' or well (of a normal polarity Kippenhahn-Schlueter type) is formed, which supports the prominence at or near the field apex.

Determining the Role of Sediment Deposition and Transport in the Formation and Maintenance of Tree Islands in the Florida Everglades

NASA Astrophysics Data System (ADS)

Mitchell-Bruker, S.; Childers, D.; Ross, M.; Leonard, L.; Solo-Gabriel, H.; Stothoff, S.

2002-05-01

Tree islands are a prominent feature in the Everglades ridge and slough wetlands. These tree islands are believed to be a remnant of the historical pre-drainage flow system. Within Everglades National Park, hardwood hammock and bayhead tree islands commonly form as teardrop-shaped mounds, rising above the sawgrass marsh. These tree islands are usually oriented along the direction of surface water flow, with the highest elevation and widest part of the island at the upstream head. The island narrows as it descends into the marsh at the downstream end, terminating in a tail that sometimes includes a zone of dead or dying sawgrass. The shape and orientation of the tree islands suggests that surface water flow has been instrumental in their formation, however occasional flow measurements indicate that the slow moving water of the Everglades does not provide sufficient energy to transport even moderate amounts of suspended sediment. This low flow velocity, coupled with the extremely low turbidity of the Everglades water suggests that if sediment transport and deposition processes are instrumental in forming tree islands, the process is probably occurring over short distances and long time intervals. It is also possible that concentration and transport of nutrients is an important element in tree island formation. Because the Everglades marsh is a low nutrient environment, processes that create areas of increased phosphorous concentration result in changes in the vegetation. Because many hardwood hammock and bayhead tree islands have heads that are situated on bedrock highs, the higher and drier elevation of the head allows for trees to grow. These trees could concentrate phosphorous either by acting as wildlife attractors, or by acting as \\x8Dphosphorous pumpsŒ, transporting groundwater with high concentrations of phosphorous through the roots to the tree. We are characterizing vegetation, litter fall, sediments, surface water flow, hydrologic gradients and nutrient gradients on tree islands and in the surrounding marsh. These data will be analyzed using statistical and hydrologic models to test the hypothesis that surface water flow is an essential force in forming and maintaining tree islands. A sediment and nutrient transport model is being developed to apply these data to scenarios for flow in a vegetated wetland. By constraining model parameters to the limits supported by these data, the full range of possible flow and transport scenarios can be tested in the model. These model results, along with statistical analysis will be used to support or reject the hypothesis that sediment and nutrient transport are key components in the formation of hardwood hammock and bay head tree islands.

Comparison of Two Methods Used to Model Shape Parameters of Pareto Distributions

USGS Publications Warehouse

Liu, C.; Charpentier, R.R.; Su, J.

2011-01-01

Two methods are compared for estimating the shape parameters of Pareto field-size (or pool-size) distributions for petroleum resource assessment. Both methods assume mature exploration in which most of the larger fields have been discovered. Both methods use the sizes of larger discovered fields to estimate the numbers and sizes of smaller fields: (1) the tail-truncated method uses a plot of field size versus size rank, and (2) the log-geometric method uses data binned in field-size classes and the ratios of adjacent bin counts. Simulation experiments were conducted using discovered oil and gas pool-size distributions from four petroleum systems in Alberta, Canada and using Pareto distributions generated by Monte Carlo simulation. The estimates of the shape parameters of the Pareto distributions, calculated by both the tail-truncated and log-geometric methods, generally stabilize where discovered pool numbers are greater than 100. However, with fewer than 100 discoveries, these estimates can vary greatly with each new discovery. The estimated shape parameters of the tail-truncated method are more stable and larger than those of the log-geometric method where the number of discovered pools is more than 100. Both methods, however, tend to underestimate the shape parameter. Monte Carlo simulation was also used to create sequences of discovered pool sizes by sampling from a Pareto distribution with a discovery process model using a defined exploration efficiency (in order to show how biased the sampling was in favor of larger fields being discovered first). A higher (more biased) exploration efficiency gives better estimates of the Pareto shape parameters. ?? 2011 International Association for Mathematical Geosciences.

Los Alamos Discovers Super Efficient Solar Using Perovskite Crystals

ScienceCinema

Mohite, Aditya; Nie, Wanyi

2018-05-11

State-of-the-art photovoltaics using high-purity, large-area, wafer-scale single-crystalline semiconductors grown by sophisticated, high temperature crystal-growth processes offer promising routes for developing low-cost, solar-based clean global energy solutions for the future. Solar cells composed of the recently discovered material organic-inorganic perovskites offer the efficiency of silicon, yet suffer from a variety of deficiencies limiting the commercial viability of perovskite photovoltaic technology. In research to appear in Science, Los Alamos National Laboratory researchers reveal a new solution-based hot-casting technique that eliminates these limitations, one that allows for the growth of high-quality, large-area, millimeter-scale perovskite crystals and demonstrates that highly efficient and reproducible solar cells with reduced trap assisted recombination can be realized.

Herpetofaunal Community Change in Multiple Habitats after Fifteen Years in a Southwest Florida Preserve, USA

PubMed Central

Cassani, John R.; Croshaw, Dean A.; Bozzo, Joseph; Brooks, Brenda; Everham, Edwin M.; Ceilley, David W.; Hanson, Deborah

2015-01-01

Herpetofaunal declines have been documented globally, and southern Florida, USA, is an especially vulnerable region because of high impacts from hydrological perturbations and nonindigenous species. To assess the extent of recent change in herpetofauna community composition, we established a baseline inventory during 1995-97 at a managed preserve in a habitat rich area of southwest Florida, and repeated our sampling methods fifteen years later (2010-11). Nine drift fence arrays were placed in four habitat types: mesic flatwood, mesic hammock, depression marsh, and wet prairie. Trapping occurred daily for one week during 7-8 sampling runs in each period (57 and 49 total sampling days, respectively). Species richness was maintained in mesic hammock habitats but varied in the others. Catch rates of several native species (Anaxyrus terrestris, Lithobates grylio, Anolis carolinensis, Nerodia fasciata) declined significantly. Other native species (Lithobates sphenocephalus, Siren lacertian, and Notophthalmus viridescens piaropicola) that were abundant in 1995-97 declined by greater than 50%. Catch rate of only two species (the nonindigenous Anolis sagrei and the native Diadophis punctatus) increased significantly. Hierarchical cluster analysis indicated similarity within habitat types but significant dissimilarity between sampling periods, confirming shifts in community composition. Analysis of individual species’ contributions to overall similarity across habitats shows a shift from dominance of native species in the 1990s to increased importance of nonindigenous species in 2010-11. Although natural population fluctuations may have influenced differences between the two sampling periods, our results suggest considerable recent change in the structure and composition of this southwest Florida herpetofaunal community. The causes are unknown, but hydrological shifts and ecological impacts of nonindigenous species may have contributed. PMID:26016475

Hurst exponent and prediction based on weak-form efficient market hypothesis of stock markets

NASA Astrophysics Data System (ADS)

Eom, Cheoljun; Choi, Sunghoon; Oh, Gabjin; Jung, Woo-Sung

2008-07-01

We empirically investigated the relationships between the degree of efficiency and the predictability in financial time-series data. The Hurst exponent was used as the measurement of the degree of efficiency, and the hit rate calculated from the nearest-neighbor prediction method was used for the prediction of the directions of future price changes. We used 60 market indexes of various countries. We empirically discovered that the relationship between the degree of efficiency (the Hurst exponent) and the predictability (the hit rate) is strongly positive. That is, a market index with a higher Hurst exponent tends to have a higher hit rate. These results suggested that the Hurst exponent is useful for predicting future price changes. Furthermore, we also discovered that the Hurst exponent and the hit rate are useful as standards that can distinguish emerging capital markets from mature capital markets.

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. - NASA astronaut candidates Anne McClain, from left, Christina Hammock, Tyler "Nick" Hague and Jessica Meir walk through the transfer aisle of the Vehicle Assembly Building at NASA's Kennedy Space Center during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Lunch at Beach House

NASA Image and Video Library

2014-03-04

CAPE CANAVERAL, Fla. - NASA astronaut candidates, from left, Anne McClain, Christina Hammock and Jessica Meir stand on the beach overlooking the Atlantic Ocean at the Beach House at NASA's Kennedy Space Center. The Beach House is a traditional gathering place for astronauts before they fly into space. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Daniel Casper

ASCANS Class of 2013 Tour CCAFS

NASA Image and Video Library

2014-03-04

CAPE CANAVERAL, Fla. – NASA astronaut candidates Anne McClain, from left counterclockwise, Victor Glover, Jessica Meir, Andrew Morgan, Christina Hammock, Josh Cassada and Nicole Mann visit the Mercury 7 memorial at Cape Canaveral Air Force Station in Florida, adjacent to NASA's Kennedy Space Center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Frankie Martin

ASCANS Class of 2013 Tour CCAFS

NASA Image and Video Library

2014-03-04

CAPE CANAVERAL, Fla. – NASA astronaut candidates Anne McClain, from left, Jessica Meir, Victor Glover, Andrew Morgan, Tyler "Nick" Hague, Josh Cassada, Christina Hammock and Nicole Mann visit the Mercury 7 memorial at Cape Canaveral Air Force Station in Florida, adjacent to NASA's Kennedy Space Center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Frankie Martin

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – NASA astronaut candidates Jessica Meir, Christina Hammock, Anne McClain and Josh Cassada listen to details about Launch Complex 39B at NASA's Kennedy Space Center during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. - NASA astronaut candidates Andrew Morgan, from left Josh Cassada, Tyler "Nick" Hague, Christina Hammock and Victor Glover tour one of the high bays of the Vehicle Assembly Building at NASA's Kennedy Space Center during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-99wl13

NASA Image and Video Library

1999-01-08

KENNEDY SPACE CENTER, FLA. -- Its newly grown, wispy feathers reflecting light like a halo, an unidentified baby bird waits, probably for its next meal, in its stick-assembled nest. The nest is in the Merritt Island National Wildlife Refuge, which shares a boundary with KSC. Hardwood hammocks and pine flatwoods share the 92,000-acre refuge with fresh-water impoundments, salt-water estuaries and brackish marshes. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators

KSC-2009-2600

NASA Image and Video Library

2009-04-10

CAPE CANAVERAL, Fla. –Black-necked stilts look as if they're doing handstands on their mirror images in the shallow water of the Turn Basin behind the NASA News Center at NASA's Kennedy Space Center in Florida. The species inhabits salt marshes and coastal bays in the East, ranging along the Atlantic Coast from Delaware and the Carolinas to northern South America. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Ben Smegelsky

State of STEM (SoSTEM) Address

NASA Image and Video Library

2014-01-29

Dr. John P. Holdren, Assistant to the President for Science and Technology and Director of the White House Office of Science & Technology Policy, center, poses for a group photograph with NASA's 2013 astronaut candidates, from left, Josh A. Cassada, Nicole Aunapu Mann, Jessica U. Meir, Tyler N. "Nick" Hague, Holdren, Victor J. Glover, Christina M. Hammock, Andrew R. Morgan, and, Anne C. McClain at the annual White House State of Science, Technology, Engineering, and Math (SoSTEM) address, Wednesday, Jan. 29, 2014, in the South Court Auditorium in the Eisenhower Executive Office Building on the White House complex in Washington. Photo Credit: (NASA/Bill Ingalls)

KSC-08pd4128

NASA Image and Video Library

2008-12-23

CAPE CANAVERAL, Fla. – Hooded Merganser ducks swim on a pond in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. Their habitat includes wooded ponds, lakes and rivers. They are most often seen along rivers and estuaries during the fall and winter. They feed chiefly on small fish, which they pursue in long, rapid, underwater dives, and also frogs and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4129

NASA Image and Video Library

2008-12-23

CAPE CANAVERAL, Fla. – Hooded Merganser ducks swim on a pond in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. Their habitat includes wooded ponds, lakes and rivers. They are most often seen along rivers and estuaries during the fall and winter. They feed chiefly on small fish, which they pursue in long, rapid, underwater dives, and also frogs and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4121

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – Near NASA's Kennedy Space Center in Florida, a pied-billed Grebe swims on a pond in the Merritt island National Wildlife Refuge. The normal black band on its bill is lacking in winter. The most common grebe in eastern North America, the pied-billed Grebe inhabits marshes and ponds, eating small fish, crustaceans, especially crayfish, and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4122

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – Near NASA's Kennedy Space Center in Florida, a male Northern pintail duck swims on a pond in the Merritt island National Wildlife Refuge. Pintails inhabit marshes, prairie ponds and tundra. Widely distributed across the U.S. and Canada, the breed winters south to Central America and the West Indies. It feeds largely on seeds of aquatic plants but may also take small aquatic animals. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-2011-8332

NASA Image and Video Library

2011-12-19

CAPE CANAVERAL, Fla. -- From its perch atop a mangrove, this great blue heron appears to oversee the activities of the assortment of birds in the surrounding waters at NASA's Kennedy Space Center in Florida. The birds gathered in this particular group include coots, shovelbills and pintails. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann

KSC-2014-2531

NASA Image and Video Library

2014-05-12

CAPE CANAVERAL, Fla. -- A wild turkey tries to blend into the palmetto underbrush near the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Ben Smegelsky

KSC-2014-2530

NASA Image and Video Library

2014-05-12

CAPE CANAVERAL, Fla. -- A wild turkey heads for the safety of the palmetto underbrush near the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Ben Smegelsky

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. - Mary Hanna, crawler-transporter integration manager, discusses the crawler-transporter with astronaut candidates Nicole Mann, Anne McClain, Christina Hammock, Jessica Meir, Andrew Morgan, Josh Cassada, Tyler "Nick" Hague and Victor Glover in the Vehicle Assembly Building at NASA's Kennedy Space Center during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – NASA astronaut candidates Nicole Mann, Victor Glover, Tyler "Nick" Hague, Andrew Morgan, Christina Hammock, Jessica Meir, Josh Cassada and Anne McClain listen to details about Launch Complex 39B at NASA's Kennedy Space Center during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Saturn V & LCC Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – NASA astronaut candidates Andrew Morgan, from left, Nicole Mann, Tyler Nick Hague, Josh Cassada, Anne McClain, Christina Hammock and Victor Glover listen to a discussion about firing rooms inside the Launch Control Center at Kennedy Space Center in Florida during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-08pd3169

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. - On the grounds of Kennedy Space Center, a female Golden-Silk Spider repairs its web. The female can be identified by its brownish-green abdomen with a white spotted irregular pattern. The golden-silk spider repairs the webbing each day, replacing half but never the whole web at one time. Its web may measure two to three feet across. The center shares a boundary with the Merritt Island Wildlife Nature Refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals. Photo credit: NASA/Dimitri Gerondidakis

KSC-2014-2524

NASA Image and Video Library

2014-05-08

CAPE CANAVERAL, Fla. -- An alligator lounges in the water off Schwartz Road at NASA's Kennedy Space Center in Florida. Alligators can be spotted in the drainage canals and other waterways surrounding the space center. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Daniel Casper

KSC-08pd3164

NASA Image and Video Library

2008-10-14

CAPE CANAVERAL, Fla. - On the grounds of Kennedy Space Center, a female Golden-Silk Spider repairs its web. The female can be identified by its brownish-green abdomen with a white spotted irregular pattern. The golden-silk spider repairs the webbing each day, replacing half but never the whole web at one time. Its web may measure two to three feet across. The center shares a boundary with the Merritt Island Wildlife Nature Refuge, consisting of 140,000 acres. The Refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks that provide habitat for more than 1,500 species of plants and animals. Photo credit: NASA/Dimitri Gerondidakis

KSC-2012-4541

NASA Image and Video Library

2012-08-17

CAPE CANAVERAL, Fla. – Two fish swim near the Banana River shoreline at NASA's Kennedy Space Center in Florida. Kennedy is located on Merritt Island, a barrier island, about 34 miles long and varying in width from five to 10 miles. Only 6,000 acres are actually used for operational activities. The Kennedy Space Center is also a National Wildlife Refuge. Consisting of 140,000 acres, the refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods and hardwood hammocks providing habitat for more than 1,500 species of plants and animals. For more information, visit: http://ipv6.nasa.gov/centers/kennedy/shuttleoperations/alligators/kscovrv.html Photo credit: NASA/Ben Smegelsky

KSC-08pd4119

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – Near NASA's Kennedy Space Center in Florida, on a pond in the Merritt island National Wildlife Refuge, a male hooded Merganser duck swims with a female. The Merganser's habitat includes wooded ponds, lakes and rivers. They are most often seen along rivers and estuaries during the fall and winter. They feed chiefly on small fish, which they pursue in long, rapid, underwater dives, and also frogs and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4118

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – Near NASA's Kennedy Space Center in Florida, on a pond in the Merritt island National Wildlife Refuge, a male hooded Merganser duck stretches its wings. The Merganser's habitat includes wooded ponds, lakes and rivers. They are most often seen along rivers and estuaries during the fall and winter. They feed chiefly on small fish, which they pursue in long, rapid, underwater dives, and also frogs and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4126

NASA Image and Video Library

2008-12-23

CAPE CANAVERAL, Fla. – A snowy egret stands in the shallow water of a pond in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. A type of heron, the snowy egret inhabits salt marshes, ponds, rice fields and shallow coastal bays ranging from Maine to southern South America on the east coast. It can also be found in California and Oklahoma to the Gulf of Mexico. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-08pd4117

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – Near NASA's Kennedy Space Center in Florida, on a pond in the Merritt island National Wildlife Refuge, a male hooded Merganser duck swims with two females. Their habitat includes wooded ponds, lakes and rivers. They are most often seen along rivers and estuaries during the fall and winter. They feed chiefly on small fish, which they pursue in long, rapid, underwater dives, and also frogs and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-99wl10

NASA Image and Video Library

1999-01-08

KENNEDY SPACE CENTER, FLA. -- Ducks take flight across the marshes of the Merritt Island National Wildlife Refuge at Kennedy Space Center. The duck at top-center is a pintail, which can be found in marshes, prairie ponds and tundra, and salt marshes in winter. They range from Alaska and Greenland south to Central America and the West Indies. The open waters of the Wildlife Refuge provide wintering areas for 23 species of migratory waterfowl as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds. The refuge comprises 92,000 acres, ranging from fresh-water impoundments, salt-water estuaries and brackish marshes to hardwood hammocks and pine flatwoods

Control of nitromethane photoionization efficiency with shaped femtosecond pulses.

PubMed

Roslund, Jonathan; Shir, Ofer M; Dogariu, Arthur; Miles, Richard; Rabitz, Herschel

2011-04-21

The applicability of adaptive femtosecond pulse shaping is studied for achieving selectivity in the photoionization of low-density polyatomic targets. In particular, optimal dynamic discrimination (ODD) techniques exploit intermediate molecular electronic resonances that allow a significant increase in the photoionization efficiency of nitromethane with shaped near-infrared femtosecond pulses. The intensity bias typical of high-photon number, nonresonant ionization is accounted for by reference to a strictly intensity-dependent process. Closed-loop adaptive learning is then able to discover a pulse form that increases the ionization efficiency of nitromethane by ∼150%. The optimally induced molecular dynamics result from entry into a region of parameter space inaccessible with intensity-only control. Finally, the discovered pulse shape is demonstrated to interact with the molecular system in a coherent fashion as assessed from the asymmetry between the response to the optimal field and its time-reversed counterpart.

Discovering Synergistic Drug Combination from a Computational Perspective.

PubMed

Ding, Pingjian; Luo, Jiawei; Liang, Cheng; Xiao, Qiu; Cao, Buwen; Li, Guanghui

2018-03-30

Synergistic drug combinations play an important role in the treatment of complex diseases. The identification of effective drug combination is vital to further reduce the side effects and improve therapeutic efficiency. In previous years, in vitro method has been the main route to discover synergistic drug combinations. However, many limitations of time and resource consumption lie within the in vitro method. Therefore, with the rapid development of computational models and the explosive growth of large and phenotypic data, computational methods for discovering synergistic drug combinations are an efficient and promising tool and contribute to precision medicine. It is the key of computational methods how to construct the computational model. Different computational strategies generate different performance. In this review, the recent advancements in computational methods for predicting effective drug combination are concluded from multiple aspects. First, various datasets utilized to discover synergistic drug combinations are summarized. Second, we discussed feature-based approaches and partitioned these methods into two classes including feature-based methods in terms of similarity measure, and feature-based methods in terms of machine learning. Third, we discussed network-based approaches for uncovering synergistic drug combinations. Finally, we analyzed and prospected computational methods for predicting effective drug combinations. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Hydrology, Water Quality, and Aquatic Communities of Selected Springs in the St. Johns River Water Management District, Florida

USGS Publications Warehouse

Walsh, Stephen J.; Knowles, Leel; Katz, Brian G.; Strom, Douglas G.

2009-01-01

Hydrologic, physicochemical, and aquatic community data were collected and compiled by the U.S. Geological Survey for selected springs within the St. Johns River Water Management District from January 2004 to October 2007. Nine springs were included in this study: Alexander, Apopka, Bugg, De Leon, Gemini, Green, Rock, Silver Glen, and Wekiwa. Urban lands increased in Alexander, Apopka, De Leon, Gemini, Green, and Wekiwa springsheds between 1973 and 2004, accompanied by a loss of forested and/or agricultural lands in most springsheds. Forested cover increased and open surface waters and wetlands decreased in the Bugg and Rock springsheds. Although rainfall did not change significantly over time in each springshed, spring discharge decreased significantly in De Leon, Fern Hammock, Rock, Silver, and Wekiwa Springs. Nitrate concentrations increased significantly with time in Apopka, Fern Hammock, Gemini Springs run, and Juniper Springs, and decreased significantly in Alexander Spring, Bugg Spring run, Rock Springs, and Wekiwa Springs. Phosphorus increased significantly with time in Juniper Springs and decreased significantly in Apopka, De Leon, Rock, Silver Glen, and Wekiwa Springs. Benthic macroinvertebrate communities ranged from relatively low diversity assemblages (Green Spring) to assemblages with high taxonomic richness, diversity, and dominance (Rock and De Leon Springs). Shannon-Wiener diversity index averages among samples pooled by spring were lowest for Apopka Spring and greatest for Rock, Bugg, and Silver Glen Springs. Mean Stream Condition Index for pooled samples per spring was lowest for De Leon and Gemini Springs and highest for Rock and Wekiwa Springs. Mean percentages of very tolerant taxa were lowest for Alexander Spring and highest for Bugg and Green Springs. Fish community richness was lowest for Green Spring, and greatest for Alexander Spring run and Silver Glen Springs. Forty five fish species representing 35 genera and 23 families were collected or observed from all springs in this study. Samples were dominated by centrarchids, cyprinids, fundulids, atherinopsids, and poeciliids.

Ground penetrating radar imaging of cap rock, caliche and carbonate strata

USGS Publications Warehouse

Kruse, S.E.; Schneider, J.C.; Campagna, D.J.; Inman, J.A.; Hickey, T.D.

2000-01-01

Field experiments show ground penetrating radar (GPR) can be used to image shallow carbonate stratigraphy effectively in a variety of settings. In south Florida, the position and structure of cap rock cover on limestone can be an important control on surface water flow and vegetation, but larger scale outcrops (tens of meters) of cap rock are sparse. GPR mapping through south Florida prairie, cypress swamp and hardwood hammock resolves variations in thickness and structure of cap rock to ~3 m and holds the potential to test theories for cap rock-vegetation relationships. In other settings, carbonate strata are mapped to test models for the formation of local structural anomalies. A test of GPR imaging capabilities on an arid caliche (calcrete) horizon in southeastern Nevada shows depth penetration to ~2 m with resolution of the base of caliche. GPR profiling also succeeds in resolving more deeply buried (~5 m) limestone discontinuity surfaces that record subaerial exposure in south Florida. (C) 2000 Elsevier Science B.V. All rights reserved.Field experiments show ground penetrating radar (GPR) can be used to image shallow carbonate stratigraphy effectively in a variety of settings. In south Florida, the position and structure of cap rock cover on limestone can be an important control on surface water flow and vegetation, but larger scale outcrops (tens of meters) of cap rock are sparse. GPR mapping through south Florida prairie, cypress swamp and hardwood hammock resolves variations in thickness and structure of cap rock to approx. 3 m and holds the potential to test theories for cap rock-vegetation relationships. In other settings, carbonate strata are mapped to test models for the formation of local structural anomalies. A test of GPR imaging capabilities on an arid caliche (calcrete) horizon in southeastern Nevada shows depth penetration to approx. 2 m with resolution of the base of caliche. GPR profiling also succeeds in resolving more deeply buried (approx. 5 m) limestone discontinuity surfaces that record subaerial exposure in south Florida.

Social determinants of long lasting insecticidal hammock use among the Ra-glai ethnic minority in Vietnam: implications for forest malaria control.

PubMed

Grietens, Koen Peeters; Xuan, Xa Nguyen; Ribera, Joan; Duc, Thang Ngo; Bortel, Wim van; Ba, Nhat Truong; Van, Ky Pham; Xuan, Hung Le; D'Alessandro, Umberto; Erhart, Annette

2012-01-01

Long-lasting insecticidal hammocks (LLIHs) are being evaluated as an additional malaria prevention tool in settings where standard control strategies have a limited impact. This is the case among the Ra-glai ethnic minority communities of Ninh Thuan, one of the forested and mountainous provinces of Central Vietnam where malaria morbidity persist due to the sylvatic nature of the main malaria vector An. dirus and the dependence of the population on the forest for subsistence--as is the case for many impoverished ethnic minorities in Southeast Asia. A social science study was carried out ancillary to a community-based cluster randomized trial on the effectiveness of LLIHs to control forest malaria. The social science research strategy consisted of a mixed methods study triangulating qualitative data from focused ethnography and quantitative data collected during a malariometric cross-sectional survey on a random sample of 2,045 study participants. To meet work requirements during the labor intensive malaria transmission and rainy season, Ra-glai slash and burn farmers combine living in government supported villages along the road with a second home at their fields located in the forest. LLIH use was evaluated in both locations. During daytime, LLIH use at village level was reported by 69.3% of all respondents, and in forest fields this was 73.2%. In the evening, 54.1% used the LLIHs in the villages, while at the fields this was 20.7%. At night, LLIH use was minimal, regardless of the location (village 4.4%; forest 6.4%). Despite the free distribution of insecticide-treated nets (ITNs) and LLIHs, around half the local population remains largely unprotected when sleeping in their forest plot huts. In order to tackle forest malaria more effectively, control policies should explicitly target forest fields where ethnic minority farmers are more vulnerable to malaria.

Social Determinants of Long Lasting Insecticidal Hammock-Use Among the Ra-Glai Ethnic Minority in Vietnam: Implications for Forest Malaria Control

PubMed Central

Muela Ribera, Joan; Ngo Duc, Thang; van Bortel, Wim; Truong Ba, Nhat; Van, Ky Pham; Le Xuan, Hung; D'Alessandro, Umberto; Erhart, Annette

2012-01-01

Background Long-lasting insecticidal hammocks (LLIHs) are being evaluated as an additional malaria prevention tool in settings where standard control strategies have a limited impact. This is the case among the Ra-glai ethnic minority communities of Ninh Thuan, one of the forested and mountainous provinces of Central Vietnam where malaria morbidity persist due to the sylvatic nature of the main malaria vector An. dirus and the dependence of the population on the forest for subsistence - as is the case for many impoverished ethnic minorities in Southeast Asia. Methods A social science study was carried out ancillary to a community-based cluster randomized trial on the effectiveness of LLIHs to control forest malaria. The social science research strategy consisted of a mixed methods study triangulating qualitative data from focused ethnography and quantitative data collected during a malariometric cross-sectional survey on a random sample of 2,045 study participants. Results To meet work requirements during the labor intensive malaria transmission and rainy season, Ra-glai slash and burn farmers combine living in government supported villages along the road with a second home at their fields located in the forest. LLIH use was evaluated in both locations. During daytime, LLIH use at village level was reported by 69.3% of all respondents, and in forest fields this was 73.2%. In the evening, 54.1% used the LLIHs in the villages, while at the fields this was 20.7%. At night, LLIH use was minimal, regardless of the location (village 4.4%; forest 6.4%). Discussion Despite the free distribution of insecticide-treated nets (ITNs) and LLIHs, around half the local population remains largely unprotected when sleeping in their forest plot huts. In order to tackle forest malaria more effectively, control policies should explicitly target forest fields where ethnic minority farmers are more vulnerable to malaria. PMID:22253852

Substructure coupling in the frequency domain

NASA Technical Reports Server (NTRS)

1985-01-01

Frequency domain analysis was found to be a suitable method for determining the transient response of systems subjected to a wide variety of loads. However, since a large number of calculations are performed within the discrete frequency loop, the method loses it computational efficiency if the loads must be represented by a large number of discrete frequencies. It was also discovered that substructure coupling in the frequency domain work particularly well for analyzing structural system with a small number of interface and loaded degrees of freedom. It was discovered that substructure coupling in the frequency domain can lead to an efficient method of obtaining natural frequencies of undamped structures. It was also found that the damped natural frequencies of a system may be determined using frequency domain techniques.

ASCANS Class of 2013 Tour the O&C with Cabana

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Operations and Checkout Building of NASA's Kennedy Space Center in Florida, astronaut candidate Christina Hammock listens to a briefing on preparations for the launch the Orion spacecraft on Exploration Flight Test EFT-1. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour CCAFS

NASA Image and Video Library

2014-03-04

CAPE CANAVERAL, Fla. – NASA's latest astronaut class meets with a member of the 45th Space Wing in the Cape Commander's Building at Cape Canaveral Air Force Station in Florida, adjacent to NASA's Kennedy Space Center. The astronaut candidates are, from left, Josh Cassada, Andrew Morgan, Jessica Meir, Anne McClain, Nicole Mann, Christina Hammock, Tylor "Nick" Hague and Victor Glover. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Frankie Martin

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. - NASA astronaut candidates Tyler "Nick" Hague, from left, Andrew Morgan, Jessica Meir, Christina Hammock, Mary Hanna, crawler-transporter integration manager, astronaut candidates Nicole Mann, Anne McClain, Josh Cassada and Victor Glover pose in front of a crawler-transporter inside the Vehicle Assembly Building at NASA's Kennedy Space Center during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-2014-2533

NASA Image and Video Library

2014-05-12

CAPE CANAVERAL, Fla. -- A baby alligator suns himself on the bank of a canal near the north gate on NASA's Kennedy Space Center in Florida. A typical, adult American alligator will reach a weight of 790 pounds and 13 feet in length. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Ben Smegelsky

KSC-2014-2532

NASA Image and Video Library

2014-05-12

CAPE CANAVERAL, Fla. -- A baby alligator takes a dip in a canal near the north gate on NASA's Kennedy Space Center in Florida. A typical, adult American alligator will reach a weight of 790 pounds and 13 feet in length. The center coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The refuge comprises a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks. These habitats provide sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Ben Smegelsky

KSC-2012-2570

NASA Image and Video Library

2012-04-20

CAPE CANAVERAL, Fla. – A bobcat strolls across the causeway between NASA’s Kennedy Space Center and Cape Canaveral Air Force Station in Florida, oblivious to everything but the hunt for its next meal. The cat is seldom observed during the day unless scared from its daytime shelter. It is the last large mammalian predator remaining on the center. Kennedy and the Merritt Island National Wildlife Refuge mutually reside on 140,000 acres on central Florida’s east coast. The area’s coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks provide habitats for more than 1,000 species of plants and animals, including about 331 species of birds. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Jim Grossmann

KSC-2012-1808

NASA Image and Video Library

2012-03-14

CAPE CANAVERAL, Fla. – Gotcha! A raccoon triggers a motion-activated remote camera set up for this purpose at NASA’s Kennedy Space Center in Florida. These nocturnal creatures are abundant in the area and usually do not venture out in the daytime except when breeding or caring for their young. In the background are the lights on Launch Pad 39A. Kennedy and the Merritt Island National Wildlife Refuge mutually reside on 140,000 acres on central Florida’s east coast. The area’s coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks provide habitats for more than 1,500 species of plants and animals, including about 331 species of birds. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Tony Gray

KSC-2014-2679

NASA Image and Video Library

2014-05-23

CAPE CANAVERAL, Fla. -- A bobcat prowls through the grass near the Press Site at NASA's Kennedy Space Center in Florida. The center, the only launch site for crewed missions from U.S. soil, coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The cat is the last large mammalian predator remaining on the center. The refuge provides a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks, and is a sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Kim Shiflett

KSC-2014-2681

NASA Image and Video Library

2014-05-23

CAPE CANAVERAL, Fla. -- A bobcat continues on its way past the Press Site at NASA's Kennedy Space Center in Florida. The center, the only launch site for crewed missions from U.S. soil, coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The cat is the last large mammalian predator remaining on the center. The refuge provides a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks, and is a sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Kim Shiflett

KSC-2014-2680

NASA Image and Video Library

2014-05-23

CAPE CANAVERAL, Fla. -- A bobcat retreats from the limelight near the Press Site at NASA's Kennedy Space Center in Florida. The center, the only launch site for crewed missions from U.S. soil, coexists with the Merritt Island National Wildlife Refuge, which encompasses 140,000 acres. The cat is the last large mammalian predator remaining on the center. The refuge provides a wide variety of habitats, including coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks, and is a sanctuary for more than 1,500 species of plants and animals, including more than 330 species of birds, 31 mammals, 117 fishes, and 65 amphibians and reptiles. For additional information about the refuge, visit http://www.fws.gov/merrittisland. Photo credit: NASA/Kim Shiflett

Posterior shoulder instability managed by arthroscopic acromial pediculated bone-block. Technique.

PubMed

Métais, P; Grimberg, J; Clavert, P; Kouvalchouk, J-F; Sirveaux, F; Nourissat, G; Garret, J; Mansat, P; Godenèche, A

2017-12-01

In posterior shoulder instability (recurrent dislocation, involuntary posterior subluxation or voluntary subluxation that has become involuntary), surgery may be considered in case of failure of functional treatment if there are no psychological contraindications. Acromial bone-block with pediculated deltoid flap, as described by Kouvalchouk, is an alternative to iliac bone-block, enabling triple shoulder locking by the blocking effect, the retention hammock provided by the deltoid flap and posterior capsule repair. Arthroscopy allows shoulder joint exploration and diagnosis of associated lesions, with opening and conservation of the posterior capsule; it greatly facilitates bone-block positioning and capsule reinsertion. The present report describes the procedure in detail. Technical note. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Landsat Application of Remote Sensing to Shoreline-form Analysis. [Cape Hatteras, North Carolina and Assateague Island, Virginia

NASA Technical Reports Server (NTRS)

Dolan, R. (Principal Investigator); Heywood, J. E.

1975-01-01

The author has identified the following significant results. Areas of the coast were selected which have historically shown vulnerability to storm damage. On Assateague Island, there are six such areas: the western tip of Fishing Point; the southern National Park Service parking lot; Smith Hammocks; Fox Hill Level; Little Fox Hill Level; and the northern five kilometers of the island. Comparative analysis of these areas with other data and with large and small scale aerial photographs shows them to be associated with large overwash fans and shoreline cusping. Initial analysis of Landsat imagery and high altitude photography indicates that the areas of high vulnerability are also associated with the angular orientation of the shoreline.

KSC-2012-4540

NASA Image and Video Library

2012-08-17

CAPE CANAVERAL, Fla. – Two manatees swim near the Banana River shoreline a few miles from the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. Kennedy is located on Merritt Island, a barrier island, about 34 miles long and varying in width from five to 10 miles. Only 6,000 acres are actually used for operational activities. The Kennedy Space Center is also a National Wildlife Refuge. Consisting of 140,000 acres, the refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods and hardwood hammocks providing habitat for more than 1,500 species of plants and animals. For more information, visit: http://ipv6.nasa.gov/centers/kennedy/shuttleoperations/alligators/kscovrv.html Photo credit: NASA/Ben Smegelsky

KSC-08pd4120

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – Near NASA's Kennedy Space Center in Florida, on a pond in the Merritt island National Wildlife Refuge, a male hooded Merganser duck swims with a female (right) who is stretching her wings. The Merganser's habitat includes wooded ponds, lakes and rivers. They are most often seen along rivers and estuaries during the fall and winter. They feed chiefly on small fish, which they pursue in long, rapid, underwater dives, and also frogs and aquatic insects. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

Prominence condensation and magnetic levitation in a coronal loop

NASA Technical Reports Server (NTRS)

Van Hoven, G.; Mok, Y.; Drake, J. F.

1992-01-01

The results of a model dynamic simulation of the formation and support of a narrow prominence at the apex of a coronal magnetic loop or arcade are described. The condensation process proceeds via an initial radiative cooling and pressure drop, and a secondary siphon flow from the dense chromospheric ends. The antibuoyancy effect as the prominence forms causes a bending of the confining magnetic field, which propagates toward the semirigid ends of the magnetic loop. Thus, a wide magnetic 'hammock' or well (of the normal-polarity Kippenhahn-Schlueter-type) is formed, which supports the prominence at or near the field apex. The simplicity of this 1.5-dimensional model, with its accompanying diagnostics, elucidates the various contributions to the nonlinear dynamics of prominence condensation and levitation.

KSC-2009-2603

NASA Image and Video Library

2009-04-10

CAPE CANAVERAL, Fla. – A tall Great Blue Heron warily eyes its surroundings while standing in the shallow water behind the NASA News Center at NASA's Kennedy Space Center in Florida. A frequent sight around Kennedy, this large heron inhabits lakes, ponds, rivers and marshes in a range from Alaska south to Mexico and the West Indies. It is frequently found standing at the edge of a pond or pool, watching for fish or frogs, its principal food. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Ben Smegelsky

KSC-2009-2604

NASA Image and Video Library

2009-04-10

CAPE CANAVERAL, Fla. – A Great Blue Heron majestically takes to the air as it leaves the shallow water behind the NASA News Center at NASA's Kennedy Space Center in Florida. A frequent sight around Kennedy, this large heron inhabits lakes, ponds, rivers and marshes in a range from Alaska south to Mexico and the West Indies. It is frequently found standing at the edge of a pond or pool, watching for fish or frogs, its principal food. Kennedy shares a boundary with the Merritt Island National Wildlife Refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Ben Smegelsky

Toward an efficient Photometric Supernova Classifier

NASA Astrophysics Data System (ADS)

McClain, Bradley

2018-01-01

The Sloan Digital Sky Survey Supernova Survey (SDSS) discovered more than 1,000 Type Ia Supernovae, yet less than half of these have spectroscopic measurements. As wide-field imaging telescopes such as The Dark Energy Survey (DES) and the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS) discover more supernovae, the need for accurate and computationally cheap photometric classifiers increases. My goal is to use a photometric classification algorithm based on Sncosmo, a python library for supernova cosmology analysis, to reclassify previously identified Hubble SN and other non-spectroscopically confirmed surveys. My results will be compared to other photometric classifiers such as PSNID and STARDUST. In the near future, I expect to have the algorithm validated with simulated data, optimized for efficiency, and applied with high performance computing to real data.

Applying an efficient K-nearest neighbor search to forest attribute imputation

Treesearch

Andrew O. Finley; Ronald E. McRoberts; Alan R. Ek

2006-01-01

This paper explores the utility of an efficient nearest neighbor (NN) search algorithm for applications in multi-source kNN forest attribute imputation. The search algorithm reduces the number of distance calculations between a given target vector and each reference vector, thereby, decreasing the time needed to discover the NN subset. Results of five trials show gains...

Symmetry compression method for discovering network motifs.

PubMed

Wang, Jianxin; Huang, Yuannan; Wu, Fang-Xiang; Pan, Yi

2012-01-01

Discovering network motifs could provide a significant insight into systems biology. Interestingly, many biological networks have been found to have a high degree of symmetry (automorphism), which is inherent in biological network topologies. The symmetry due to the large number of basic symmetric subgraphs (BSSs) causes a certain redundant calculation in discovering network motifs. Therefore, we compress all basic symmetric subgraphs before extracting compressed subgraphs and propose an efficient decompression algorithm to decompress all compressed subgraphs without loss of any information. In contrast to previous approaches, the novel Symmetry Compression method for Motif Detection, named as SCMD, eliminates most redundant calculations caused by widespread symmetry of biological networks. We use SCMD to improve three notable exact algorithms and two efficient sampling algorithms. Results of all exact algorithms with SCMD are the same as those of the original algorithms, since SCMD is a lossless method. The sampling results show that the use of SCMD almost does not affect the quality of sampling results. For highly symmetric networks, we find that SCMD used in both exact and sampling algorithms can help get a remarkable speedup. Furthermore, SCMD enables us to find larger motifs in biological networks with notable symmetry than previously possible.

ASCANS Class of 2013 Tour the O&C with Cabana

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Operations and Checkout Building of NASA's Kennedy Space Center in Florida, astronaut candidates Tyler Nick Hague, left, Christina Hammock, center, and Victor Glover listen to a briefing on preparations for the launch the Orion spacecraft on Exploration Flight Test EFT-1. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour CCAFS

NASA Image and Video Library

2014-03-04

CAPE CANAVERAL, Fla. – NASA astronaut candidates Tyler "Nick" Hague, from left, Josh Cassada, Anne McClain, Nicole Mann, Christina Hammock, Jessica Meir, Andrew Morgan and Victor Glover visit Launch Complex 5 at Cape Canaveral Air Force Station in Florida, adjacent to NASA's Kennedy Space Center. The launch pad is the place where Mercury astronaut Alan Shepard lifted off on May 5, 1961 to become America's first man in space. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Frankie Martin

KSC-2012-1806

NASA Image and Video Library

2012-03-14

CAPE CANAVERAL, Fla. – Out on a nocturnal stroll, a bobcat triggers a motion-activated remote camera set up for this purpose at NASA’s Kennedy Space Center in Florida. The cat is seldom observed during the day unless scared from its daytime shelter. It is the last large mammalian predator remaining on the center. In the background are the lights on Launch Pad 39A. Kennedy and the Merritt Island National Wildlife Refuge mutually reside on 140,000 acres on central Florida’s east coast. The area’s coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks provide habitats for more than 1,500 species of plants and animals, including about 331 species of birds. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Tony Gray

KSC-2012-1807

NASA Image and Video Library

2012-03-14

CAPE CANAVERAL, Fla. – Gotcha! A bobcat out on a nocturnal stroll triggers a motion-activated remote camera set up for this purpose at NASA’s Kennedy Space Center in Florida. The cat is seldom observed during the day unless scared from its daytime shelter. It is the last large mammalian predator remaining on the center. In the background are the lights on Launch Pad 39A. Kennedy and the Merritt Island National Wildlife Refuge mutually reside on 140,000 acres on central Florida’s east coast. The area’s coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks provide habitats for more than 1,500 species of plants and animals, including about 331 species of birds. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Tony Gray

ASCANS Saturn V & LCC Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – NASA astronaut candidates Andrew Morgan, from left, Nicole Mann, Tyler Nick Hague, Josh Cassada, Anne McClain, Christina Hammock and Victor Glover listen as Steve Cox or Flight Systems and Operations Integration in Kennedy Ground Systems Development and Operations, far right, briefed on firing rooms inside the Launch Control Center at Kennedy Space Center in Florida during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-99pc66

NASA Image and Video Library

1999-01-14

KENNEDY SPACE CENTER, FLA. -- A robin perches on a branch in the Merritt Island National Wildlife Refuge, which shares a boundary with the space center. Robins range throughout North America, from Alaska to Florida. Although considered a harbinger of spring, they do winter in northern states, frequenting cedar bogs and swamps. They also winter in Florida, where they often can be seen in flocks of hundreds near KSC and the wildlife refuge, which comprises 92,000 acres, ranging from hardwood hammocks and pine flatwoods to fresh-water impoundments, salt-water estuaries and brackish marshes. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators

KSC-2012-2571

NASA Image and Video Library

2012-04-20

CAPE CANAVERAL, Fla. – A bobcat on the causeway between NASA’s Kennedy Space Center and Cape Canaveral Air Force Station in Florida pauses to check out the photographer who chanced upon it during the hunt for its next meal. The cat is seldom observed during the day unless scared from its daytime shelter. It is the last large mammalian predator remaining on the center. Kennedy and the Merritt Island National Wildlife Refuge mutually reside on 140,000 acres on central Florida’s east coast. The area’s coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks provide habitats for more than 1,000 species of plants and animals, including about 331 species of birds. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Jim Grossmann

ASCANS Saturn V & LCC Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – NASA astronaut candidates Anne McClain, from left, Andrew Morgan, Nicole Mann, Victor Glover, Christina Hammock and Josh Cassada observe the Apollo 14 command module which carried astronauts Alan Shepard, Stu Roosa and Edgar Mitchell on their lunar landing mission in 1971.The astronauts toured the Apollo Saturn V Center at Kennedy Space Center in Florida during a daylong set of briefings and tours of different facilities at NASA's primary launch center. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-08pd4124

NASA Image and Video Library

2008-12-22

CAPE CANAVERAL, Fla. – A male Anhinga perches in a shrub in the Merritt island National Wildlife Refuge, which borders NASA's Kennedy Space Center in Florida. Anhingas inhabit freshwater ponds and swamps with thick vegetation. They range from the Atlantic and Gulf coasts from North Carolina to Texas, the Mississippi Valley north to Arkansas and Tennessee, and south to southern South America. They are also referred to as snakebirds because their body is submerged when swimming, showing only the head and long, slender neck above water. The center shares a boundary with the refuge that includes salt-water estuaries, brackish marshes, hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. Photo credit: NASA/Jim Grossmann

KSC-2014-2918

NASA Image and Video Library

2014-06-13

CAPE CANAVERAL, Fla. -- A gopher tortoise lumbers down the roadway at NASA's Kennedy Space Center in Florida. Gopher tortoises are dry-land turtles that live in scrub, dry hammock, pine flatwood, coastal grassland and dune habitats. The undeveloped property on Kennedy Space Center is managed by the U.S. Fish and Wildlife Service through the Merritt Island National Wildlife Refuge. Currently, gopher tortoises are protected in some states by federal law under the Endangered Species Act ESA. The refuge provides a habitat for 14 species federally listed as threatened or endangered, including the leatherback, green, Kemps Ridley, loggerhead and Atlantic hawksbill turtles. For information on the refuge, visit http://www.fws.gov/merrittisland/Index.html. For more information on the gopher tortoise, visit http://www.fws.gov/northflorida/GopherTortoise/Gopher_Tortoise_Fact_Sheet.html. Photo credit: NASA/Daniel Casper

Using RSAT oligo-analysis and dyad-analysis tools to discover regulatory signals in nucleic sequences.

PubMed

Defrance, Matthieu; Janky, Rekin's; Sand, Olivier; van Helden, Jacques

2008-01-01

This protocol explains how to discover functional signals in genomic sequences by detecting over- or under-represented oligonucleotides (words) or spaced pairs thereof (dyads) with the Regulatory Sequence Analysis Tools (http://rsat.ulb.ac.be/rsat/). Two typical applications are presented: (i) predicting transcription factor-binding motifs in promoters of coregulated genes and (ii) discovering phylogenetic footprints in promoters of orthologous genes. The steps of this protocol include purging genomic sequences to discard redundant fragments, discovering over-represented patterns and assembling them to obtain degenerate motifs, scanning sequences and drawing feature maps. The main strength of the method is its statistical ground: the binomial significance provides an efficient control on the rate of false positives. In contrast with optimization-based pattern discovery algorithms, the method supports the detection of under- as well as over-represented motifs. Computation times vary from seconds (gene clusters) to minutes (whole genomes). The execution of the whole protocol should take approximately 1 h.

[A novel dipeptidyl peptidase IV inhibitors developed through scaffold hopping and drug splicing strategy].

PubMed

Wang, Shan-Chun; Zeng, Li-Li; Ding, Yu-Yang; Zeng, Shao-Gao; Song, Hong-Rui; Hu, Wen-Hui; Xie, Hui

2014-01-01

Though all the marketed drugs of dipeptidyl peptidase IV inhibitors are structurally different, their inherent correlation is worthy of further investigation. Herein we rapidly discovered a novel DPP-IV inhibitor 8g (IC50 = 4.9 nmol.L-1) which exhibits as good activity and selectivity as the market drugs through scaffold hopping and drug splicing strategies based on alogliptin and linagliptin. This study demonstrated that the employment of classic medicinal chemistry strategy to the marketed drugs with specific target is an efficient approach to discover novel bioactive molecules.

Efficient Craig Interpolation for Linear Diophantine (Dis)Equations and Linear Modular Equations

DTIC Science & Technology

2008-02-01

Craig interpolants has enabled the development of powerful hardware and software model checking techniques. Efficient algorithms are known for computing...interpolants in rational and real linear arithmetic. We focus on subsets of integer linear arithmetic. Our main results are polynomial time algorithms ...congruences), and linear diophantine disequations. We show the utility of the proposed interpolation algorithms for discovering modular/divisibility predicates

Containerization Policy: Considering Increased Load Weight for Certain Circumstances of Freight in Wisconsin

DOT National Transportation Integrated Search

2009-06-01

Many businesses in Wisconsin export their goods throughout the world. An efficient way of doing business internationally is through containerized shipments. This research discovered that Wisconsin's weight laws for transporting international containe...

Containerization policy : considering increased load weight for certain circumstances of freight in Wisconsin.

DOT National Transportation Integrated Search

2009-06-01

Many businesses in Wisconsin export their goods throughout the world. An efficient way of doing business internationally is : through containerized shipments. This research discovered that Wisconsins weight laws for transporting international cont...

[Our experience with mini tapes (TVT Secur and MiniArc) in the surgery for stress urinary incontinence].

PubMed

Jiménez Calvo, J; Hualde Alfaro, A; Raigoso Ortega, O; Cebrian Lostal, J L; Alvarez Bandres, S; Jiménez Parra, J; Montesino Semper, M; Santiago Gonzalez de Garibay, A

2008-01-01

The purpose of this publication is to describe the surgical technique, assess complications and short-term results of TVT secur and MiniArc tapes. From October 2006 to August 2007 it was carried out the surgical correction with TVT Secur,Women's Health & Urology, Ethicon, Johnson & Johnson, placing the tape as a hammock, to 51 patients, 38 of them with pure stress incontinence and 13 with mixed incontinence and with an average age of 57 years. From September 2007 to February 2008 41 patients, 33 of them with pure stress incontinence and 8 with mixed incontinence, with an average of age of 58 years were operated with AMS Miniarc swing system tape, posted on hammock. All procedures were performed with sedoanalgesia and Ambulatory Surgery regime. Patients were monitored in outpatient visits one month, 3 months and one year after surgical procedure. Medical history and questionnaire and ICIQ-SF, to which we added a question to quantify the degree of satisfaction, as well as physical examination, were done. We compared the results of both technical procedures and statistical survey was conducted by Student test. [Analysis with SPSS software (V14.0)]. The median follow-up in TVT secur group was 328 days (range 163-522 days) and 101 days (range 41-209 days) inthe MiniArc group. We only had one (TVT secur group) surgical complication in all the series (92 patients) being a bladder perforation. Taking into account that we read a negative test effort as an objective cure in the TVT secur group, 80.4% patients are cured and 90.2% inthe MiniArc group without significant difference between both groups (p 0095). To assess the subjective healing we utilized the ICIQ-SF test and the satisfaction extra-question and we noted that there is no significant difference between the first and third month controls. (90% of patients satisfied). 80% of patients were completely satisfied in the first year control that was only performed to TVT secur group. These new tapes show fewer complications that the TVT-O and TOT tapes and allow the possibility of placement with local anesthesia but further studies are needed.

Indoor airPLUS Videos, Podcasts, Webinars and Interviews

EPA Pesticide Factsheets

The Webinar presentations will help you discover how Indoor airPLUS homes are designed to improve indoor air quality and increase energy efficiency and learn about the key design and construction features included in Indoor airPLUS homes.

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on tiles being manufactured for the agency's Orion spacecraft. Nicole Mann holds a tile sample as Christina Hammock, left, and Tyler "Nick" Hague look on. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on tiles being manufactured for the agency's Orion spacecraft. Participating in the briefing, from the left, are Andrew Morgan, Victor Glover, Anne McClain, Christina Hammock and Tyler "Nick" Hague. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

Generalized vegetation map of north Merrit Island based on a simplified multispectral analysis

NASA Technical Reports Server (NTRS)

Poonai, P.; Floyd, W. J.; Rahmani, M. A.

1977-01-01

A simplified system for classification of multispectral data was used for making a generalized map of ground features of North Merritt Island. Subclassification of vegetation within broad categories yielded promising results which led to a completely automatic method and to the production of satisfactory detailed maps. Changes in an area north of Happy Hammocks are evidently related to water relations of the soil and are not associated with the last winter freeze-damage which affected mainly the mangrove species, likely to reestablish themselves by natural processes. A supplementary investigation involving reflectance studies in the laboratory has shown that the reflectance by detached citrus leaves, of wavelengths lying between 400 microns and 700 microns, showed some variation over a period of seven days during which the leaves were kept in a laboratory atmosphere.

KSC-2014-2854

NASA Image and Video Library

2014-06-04

CAPE CANAVERAL, Fla. -- A gopher tortoise stops for lunch beside the Launch Pad 39B beach road on NASA's Kennedy Space Center in Florida. Gopher tortoises are dry-land turtles that live in scrub, dry hammock, pine flatwood, coastal grassland and dune habitats. The undeveloped property on Kennedy Space Center is managed by the U.S. Fish and Wildlife Service through the Merritt Island National Wildlife Refuge. Currently, gopher tortoises are protected in some states by federal law under the Endangered Species Act ESA. The refuge provides a habitat for 14 species federally listed as threatened or endangered, including the leatherback, green, Kemps Ridley, loggerhead and Atlantic hawksbill turtles. For information on the refuge, visit http://www.fws.gov/merrittisland/Index.html. For more information on the gopher tortoise, visit http://www.fws.gov/northflorida/GopherTortoise/Gopher_Tortoise_Fact_Sheet.html. Photo credit: NASA/Daniel Casper

KSC-2014-2852

NASA Image and Video Library

2014-06-04

CAPE CANAVERAL, Fla. -- A gopher tortoise ambles along the Launch Pad 39B beach road on NASA's Kennedy Space Center in Florida. Gopher tortoises are dry-land turtles that live in scrub, dry hammock, pine flatwood, coastal grassland and dune habitats. The undeveloped property on Kennedy Space Center is managed by the U.S. Fish and Wildlife Service through the Merritt Island National Wildlife Refuge. Currently, gopher tortoises are protected in some states by federal law under the Endangered Species Act ESA. The refuge provides a habitat for 14 species federally listed as threatened or endangered, including the leatherback, green, Kemps Ridley, loggerhead and Atlantic hawksbill turtles. For information on the refuge, visit http://www.fws.gov/merrittisland/Index.html. For more information on the gopher tortoise, visit http://www.fws.gov/northflorida/GopherTortoise/Gopher_Tortoise_Fact_Sheet.html. Photo credit: NASA/Daniel Casper

Common angle plots as perception-true visualizations of categorical associations.

PubMed

Hofmann, Heike; Vendettuoli, Marie

2013-12-01

Visualizations are great tools of communications-they summarize findings and quickly convey main messages to our audience. As designers of charts we have to make sure that information is shown with a minimum of distortion. We have to also consider illusions and other perceptual limitations of our audience. In this paper we discuss the effect and strength of the line width illusion, a Muller-Lyer type illusion, on designs related to displaying associations between categorical variables. Parallel sets and hammock plots are both affected by line width illusions. We introduce the common-angle plot as an alternative method for displaying categorical data in a manner that minimizes the effect from perceptual illusions. Results from user studies both highlight the need for addressing line-width illusions in displays and provide evidence that common angle charts successfully resolve this issue.

Swarm intelligence in bioinformatics: methods and implementations for discovering patterns of multiple sequences.

PubMed

Cui, Zhihua; Zhang, Yi

2014-02-01

As a promising and innovative research field, bioinformatics has attracted increasing attention recently. Beneath the enormous number of open problems in this field, one fundamental issue is about the accurate and efficient computational methodology that can deal with tremendous amounts of data. In this paper, we survey some applications of swarm intelligence to discover patterns of multiple sequences. To provide a deep insight, ant colony optimization, particle swarm optimization, artificial bee colony and artificial fish swarm algorithm are selected, and their applications to multiple sequence alignment and motif detecting problem are discussed.

Contemporary screening approaches to reaction discovery and development.

PubMed

Collins, Karl D; Gensch, Tobias; Glorius, Frank

2014-10-01

New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical and strategic principles applied. We concentrate on approaches to reaction discovery as opposed to reaction development, though conceptually groundbreaking approaches to identifying efficient catalyst systems are also considered. Finally, we provide a critical overview of the utility and application of the reported methods from the perspective of a synthetic chemist, and consider the future of high-throughput screening in reaction discovery.

A serendipitous all sky survey for bright objects in the outer solar system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, M. E.; Drake, A. J.; Djorgovski, S. G.

2015-02-01

We use seven year's worth of observations from the Catalina Sky Survey and the Siding Spring Survey covering most of the northern and southern hemisphere at galactic latitudes higher than 20° to search for serendipitously imaged moving objects in the outer solar system. These slowly moving objects would appear as stationary transients in these fast cadence asteroids surveys, so we develop methods to discover objects in the outer solar system using individual observations spaced by months, rather than spaced by hours, as is typically done. While we independently discover eight known bright objects in the outer solar system, the faintestmore » having V=19.8±0.1, no new objects are discovered. We find that the survey is nearly 100% efficient at detecting objects beyond 25 AU for V≲19.1 (V≲18.6 in the southern hemisphere) and that the probability that there is one or more remaining outer solar system object of this brightness left to be discovered in the unsurveyed regions of the galactic plane is approximately 32%.« less

Carbon nanotube-supported Au-Pd alloy with cooperative effect of metal nanoparticles and organic ketone/quinone groups as a highly efficient catalyst for aerobic oxidation of amines.

PubMed

Deng, Weiping; Chen, Jiashu; Kang, Jincan; Zhang, Qinghong; Wang, Ye

2016-05-21

Functionalised carbon nanotube (CNT)-supported Au-Pd alloy nanoparticles were highly efficient catalysts for the aerobic oxidation of amines. We achieved the highest turnover frequencies (>1000 h(-1)) for the oxidative homocoupling of benzylamine and the oxidative dehydrogenation of dibenzylamine. We discovered a cooperative effect between Au-Pd nanoparticles and ketone/quinone groups on CNTs.

Nonequilibrium gas absorption in rotating permeable media

NASA Astrophysics Data System (ADS)

Baev, V. K.; Bazhaikin, A. N.

2016-08-01

The absorption of ammonia, sulfur dioxide, and carbon dioxide by water and aqueous solutions in rotating permeable media, a cellular porous disk, and a set of spaced-apart thin disks has been considered. The efficiency of cleaning air to remove these impurities is determined, and their anomalously high solubility (higher than equilibrium value) has been discovered. The results demonstrate the feasibility of designing cheap efficient rotor-type absorbers to clean gases of harmful impurities.

Open chromatin reveals the functional maize genome

USDA-ARS?s Scientific Manuscript database

Every cellular process mediated through nuclear DNA must contend with chromatin. As results from ENCODE show, open chromatin assays can efficiently integrate across diverse regulatory elements, revealing functional non-coding genome. In this study, we use a MNase hypersensitivity assay to discover o...

FNL Scientists Introduce Concept That Could Help the Immune System Respond to Vaccines | FNLCR Staging

Cancer.gov

Scientists have discovered an efficient and straightforward model to manipulate RNA nanoparticles, a new concept that could help trigger desirable activation of the immune system with vaccines and therapies. A multi-institutional team of researchers

An novel frequent probability pattern mining algorithm based on circuit simulation method in uncertain biological networks.

PubMed

He, Jieyue; Wang, Chunyan; Qiu, Kunpu; Zhong, Wei

2014-01-01

Motif mining has always been a hot research topic in bioinformatics. Most of current research on biological networks focuses on exact motif mining. However, due to the inevitable experimental error and noisy data, biological network data represented as the probability model could better reflect the authenticity and biological significance, therefore, it is more biological meaningful to discover probability motif in uncertain biological networks. One of the key steps in probability motif mining is frequent pattern discovery which is usually based on the possible world model having a relatively high computational complexity. In this paper, we present a novel method for detecting frequent probability patterns based on circuit simulation in the uncertain biological networks. First, the partition based efficient search is applied to the non-tree like subgraph mining where the probability of occurrence in random networks is small. Then, an algorithm of probability isomorphic based on circuit simulation is proposed. The probability isomorphic combines the analysis of circuit topology structure with related physical properties of voltage in order to evaluate the probability isomorphism between probability subgraphs. The circuit simulation based probability isomorphic can avoid using traditional possible world model. Finally, based on the algorithm of probability subgraph isomorphism, two-step hierarchical clustering method is used to cluster subgraphs, and discover frequent probability patterns from the clusters. The experiment results on data sets of the Protein-Protein Interaction (PPI) networks and the transcriptional regulatory networks of E. coli and S. cerevisiae show that the proposed method can efficiently discover the frequent probability subgraphs. The discovered subgraphs in our study contain all probability motifs reported in the experiments published in other related papers. The algorithm of probability graph isomorphism evaluation based on circuit simulation method excludes most of subgraphs which are not probability isomorphism and reduces the search space of the probability isomorphism subgraphs using the mismatch values in the node voltage set. It is an innovative way to find the frequent probability patterns, which can be efficiently applied to probability motif discovery problems in the further studies.

An novel frequent probability pattern mining algorithm based on circuit simulation method in uncertain biological networks

PubMed Central

2014-01-01

Background Motif mining has always been a hot research topic in bioinformatics. Most of current research on biological networks focuses on exact motif mining. However, due to the inevitable experimental error and noisy data, biological network data represented as the probability model could better reflect the authenticity and biological significance, therefore, it is more biological meaningful to discover probability motif in uncertain biological networks. One of the key steps in probability motif mining is frequent pattern discovery which is usually based on the possible world model having a relatively high computational complexity. Methods In this paper, we present a novel method for detecting frequent probability patterns based on circuit simulation in the uncertain biological networks. First, the partition based efficient search is applied to the non-tree like subgraph mining where the probability of occurrence in random networks is small. Then, an algorithm of probability isomorphic based on circuit simulation is proposed. The probability isomorphic combines the analysis of circuit topology structure with related physical properties of voltage in order to evaluate the probability isomorphism between probability subgraphs. The circuit simulation based probability isomorphic can avoid using traditional possible world model. Finally, based on the algorithm of probability subgraph isomorphism, two-step hierarchical clustering method is used to cluster subgraphs, and discover frequent probability patterns from the clusters. Results The experiment results on data sets of the Protein-Protein Interaction (PPI) networks and the transcriptional regulatory networks of E. coli and S. cerevisiae show that the proposed method can efficiently discover the frequent probability subgraphs. The discovered subgraphs in our study contain all probability motifs reported in the experiments published in other related papers. Conclusions The algorithm of probability graph isomorphism evaluation based on circuit simulation method excludes most of subgraphs which are not probability isomorphism and reduces the search space of the probability isomorphism subgraphs using the mismatch values in the node voltage set. It is an innovative way to find the frequent probability patterns, which can be efficiently applied to probability motif discovery problems in the further studies. PMID:25350277

[Transmission efficiency analysis of near-field fiber probe using FDTD simulation].

PubMed

Huang, Wei; Dai, Song-Tao; Wang, Huai-Yu; Zhou, Yun-Song

2011-10-01

A fiber probe is the key component of near-field optical technology which is widely used in high resolution imaging, spectroscopy detection and nano processing. How to improve the transmission efficiency of the fiber probe is a very important problem in the application of near-field optical technology. Based on the results of 3D-FDTD computation, the dependence of the transmission efficiency on the cone angle, the aperture diameter, the wavelength and the thickness of metal cladding is revealed. The authors have also made a comparison between naked probe and the probe with metal cladding in terms of transmission efficiency and spatial resolution. In addition, the authors have discovered the fluctuation phenomena of transmission efficiency as the wavelength of incident laser increases.

Palladium-Catalyzed Nitromethylation of Aryl Halides: An Orthogonal Formylation Equivalent

PubMed Central

Walvoord, Ryan R.; Berritt, Simon; Kozlowski, Marisa C.

2012-01-01

An efficient cross-coupling reaction of aryl halides and nitromethane was developed with the use of parallel microscale experimentation. The arylnitromethane products are precursors for numerous useful synthetic products. An efficient method for their direct conversion to the corresponding oximes and aldehydes in a one-pot operation has been discovered. The process exploits inexpensive nitromethane as a carbonyl equivalent, providing a mild and convenient formylation method that is compatible with many functional groups. PMID:22839593

Simplified dichromated gelatin hologram recording process

NASA Technical Reports Server (NTRS)

Georgekutty, Tharayil G.; Liu, Hua-Kuang

1987-01-01

A simplified method for making dichromated gelatin (DCG) holographic optical elements (HOE) has been discovered. The method is much less tedious and it requires a period of processing time comparable with that for processing a silver halide hologram. HOE characteristics including diffraction efficiency (DE), linearity, and spectral sensitivity have been quantitatively investigated. The quality of the holographic grating is very high. Ninety percent or higher diffraction efficiency has been achieved in simple plane gratings made by this process.

What currency do bumble bees maximize?

PubMed

Charlton, Nicholas L; Houston, Alasdair I

2010-08-16

In modelling bumble bee foraging, net rate of energetic intake has been suggested as the appropriate currency. The foraging behaviour of honey bees is better predicted by using efficiency, the ratio of energetic gain to expenditure, as the currency. We re-analyse several studies of bumble bee foraging and show that efficiency is as good a currency as net rate in terms of predicting behaviour. We suggest that future studies of the foraging of bumble bees should be designed to distinguish between net rate and efficiency maximizing behaviour in an attempt to discover which is the more appropriate currency.

What Currency Do Bumble Bees Maximize?

PubMed Central

Charlton, Nicholas L.; Houston, Alasdair I.

2010-01-01

In modelling bumble bee foraging, net rate of energetic intake has been suggested as the appropriate currency. The foraging behaviour of honey bees is better predicted by using efficiency, the ratio of energetic gain to expenditure, as the currency. We re-analyse several studies of bumble bee foraging and show that efficiency is as good a currency as net rate in terms of predicting behaviour. We suggest that future studies of the foraging of bumble bees should be designed to distinguish between net rate and efficiency maximizing behaviour in an attempt to discover which is the more appropriate currency. PMID:20808437

Black Phosphorus Quantum Dots for Hole Extraction of Typical Planar Hybrid Perovskite Solar Cells.

PubMed

Chen, Wei; Li, Kaiwen; Wang, Yao; Feng, Xiyuan; Liao, Zhenwu; Su, Qicong; Lin, Xinnan; He, Zhubing

2017-02-02

Black phosphorus, famous as two-dimensional (2D) materials, shows such excellent properties for optoelectronic devices such as tunable direct band gap, extremely high hole mobility (300-1000 cm 2 /(V s)), and so forth. In this Letter, facile processed black phosphorus quantum dots (BPQDs) were successfully applied to enhance hole extraction at the anode side of the typical p-i-n planar hybrid perovskite solar cells, which remarkably improved the performance of devices with photon conversion efficiency ramping up from 14.10 to 16.69%. Moreover, more detailed investigations by c-AFM, SKPM, SEM, hole-only devices, and photon physics measurements discover further the hole extraction effect and work mechanism of the BPQDs, such as nucleation assistance for the growth of large grain size perovskite crystals, fast hole extraction, more efficient hole transfer, and suppression of energy-loss recombination at the anode interface. This work definitely paves the way for discovering more and more 2D materials with high electronic properties to be used in photovoltaics and optoelectronics.

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on tiles being manufactured for the agency's Orion spacecraft. TPSF manager, Martin Wilson of Jacobs Technology, holds a heated tile sample demonstrating its ability to protect a spacecraft during the heat of reentry. Looking on, from the left, are Christina Hammock, Victor Glover and Nicole Mann. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on tiles being manufactured for the agency's Orion spacecraft. Christina Hammock holds a tool used to mill tiles designed for use on the agency's Orion spacecraft. Also looking on are Jessica Meir, on the left, and Andrew Morgan and Tyler "Nick" Hague on the right. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on tiles being manufactured for the agency's Orion spacecraft. Jessica Meir, right, holds a heated tile sample demonstrating its ability to protect a spacecraft during the heat of reentry. Looking on, are Christina Hammock, left, and Anne McClain. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour the O&C with Cabana

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Operations and Checkout Building of NASA's Kennedy Space Center in Florida, astronaut candidates pose in front of a work stand where the agency's Orion spacecraft is being prepared for Exploration Flight Test EFT-1. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station. From the left are Tyler Nick Hague, Andrew Morgan, Jessica Meir, Christina Hammock, Nicole Mann, Anne McClain, Josh Cassada and Victor Glover. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-99pc64

NASA Image and Video Library

1999-01-14

KENNEDY SPACE CENTER, FLA. -- A sandpiper wades the water in the Merritt Island National Wildlife Refuge, which shares a boundary with the space center. Sandpipers are usually seen foraging on the beach or margins of lakes, ponds, marshes or streams. The open waters of the Wildlife Refuge provide wintering areas for 23 species of migratory waterfowl as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds. The refuge comprises 92,000 acres, ranging from fresh-water impoundments, salt-water estuaries and brackish marshes to hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators

KSC-05PD-1595

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. This gopher tortoise eats its way through the grass alongside Kennedy Parkway at NASA Kennedy Space Center. The sandy soils of Florida are prime habitat for the species, the only one in Florida. Gopher tortoises thrive in many of our ecosystems, pine-oak sandhills, oak hammocks, prairies, flatwoods and coastal dunes. This and other wildlife abound throughout KSC as it shares a boundary with the Merritt Island National Wildlife Refuge, home to some of the nations rarest and most unusual species of wildlife. The wildlife refuge is a habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. In addition, the Refuge supports 19 endangered or threatened wildlife species on Federal or State lists, more than any other single refuge in the U.S. Gopher tortoises are protected by law in Florida and are listed as a Species of Special Concern.

A robin perches on a branch at KSC

NASA Technical Reports Server (NTRS)

1999-01-01

A robin perches on a branch in the Merritt Island National Wildlife Refuge, which shares a boundary with the space center. Robins range throughout North America, from Alaska to Florida. Although considered a harbinger of spring, they do winter in northern states, frequenting cedar bogs and swamps. They also winter in Florida, where they often can be seen in flocks of hundreds near KSC and the wildlife refuge, which comprises 92,000 acres, ranging from hardwood hammocks and pine flatwoods to fresh-water impoundments, salt-water estuaries and brackish marshes. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators.

Ten unique and charismatic new species of Microgastrinae wasps (Hymenoptera, Braconidae) from North America

PubMed Central

Fernandez-Triana, Jose

2018-01-01

Abstract Ten new species within four genera of Microgastrinae parasitoid wasps (Hymenoptera: Braconidae) are described from Canada and United States: Diolcogaster ichiroi, Diolcogaster miamensis, Glyptapanteles pseudotsugae, Microgaster archboldensis, Microgaster syntopic, Microplitis altissimus, Microplitis jorgeluisi, Microplitis juanmanueli, Microplitis julioalbertoi, and Microplitis mariamargaritae. The new taxa are significant because they represent the first North American records of a tropical group (species of the basimacula group in Diolcogaster), exemplify interesting ecological cases (niche-based host selection in Glyptapanteles, syntopic species in Microgaster), and showcase unique morphological features and/or altitudinal records (Microplitis). Most of the new species were collected in protected areas or areas with strong research programs (Archbold Biological Station and hammock forests near Miami, Florida; Great Sand Dunes National Park and Preserve, and Mount Evans Wilderness Area, Colorado; Sapelo Island, Georgia; Tonto National Forest, Arizona), and thus are also of value and interest for conservation and research efforts. PMID:29416399

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on thermal blankets being manufactured for agency spacecraft. Looking at sample thermal blankets are, from the left, Nicole Mann, Andrew Morgan, Christina Hammock, Josh Cassada, Jessica Meir, Tyler ‘Nick’ Hague, and Anne McClain. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

ASCANS Class of 2013 Tour

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. -- In the Thermal Protection System Facility NASA's Kennedy Space Center in Florida, agency astronaut candidates are briefed on thermal blankets being manufactured for agency spacecraft by TPSF manager, Martin Wilson of Jacobs Technology, far left. Participating in the briefing, from the left, are Christina Hammock, Tyler ‘Nick’ Hague, Victor Glover, John Cassada, Jessica Meir, Andrew Morgan and Anne McClain. Plans call for the Lockheed Martin-built Orion to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station on Exploration Flight Test EFT-1 later this year. The astronaut class of 2013 was selected by NASA after an extensive year-and-a-half search. The new group will help the agency push the boundaries of exploration and travel to new destinations in the solar system. To learn more about the astronaut class of 2013, visit: http://www.nasa.gov/astronauts/2013astroclass.html Photo credit: NASA/Kim Shiflett

KSC-2012-4542

NASA Image and Video Library

2012-08-17

CAPE CANAVERAL, Fla. – The solid rocket booster SRB retrieval ships, Liberty Star and Freedom Star, are docked in the Banana River at Cape Canaveral Air Force Station's Hangar A F. The NASA vessels were used during the space shuttle era to retrieve the SRBs following shuttle launches. Kennedy is located on Merritt Island, a barrier island, about 34 miles long and varying in width from five to 10 miles. Only 6,000 acres are actually used for operational activities. The Kennedy Space Center is also a National Wildlife Refuge. Consisting of 140,000 acres, the refuge provides a wide variety of habitats: coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods and hardwood hammocks providing habitat for more than 1,500 species of plants and animals. For more information, visit: http://ipv6.nasa.gov/centers/kennedy/shuttleoperations/alligators/kscovrv.html Photo credit: NASA/Ben Smegelsky

KSC-2014-2853

NASA Image and Video Library

2014-06-04

CAPE CANAVERAL, Fla. -- Slow and steady wins the race for this gopher tortoise, ambling along the Launch Pad 39B beach road on NASA's Kennedy Space Center in Florida. Gopher tortoises are dry-land turtles that live in scrub, dry hammock, pine flatwood, coastal grassland and dune habitats. The undeveloped property on Kennedy Space Center is managed by the U.S. Fish and Wildlife Service through the Merritt Island National Wildlife Refuge. Currently, gopher tortoises are protected in some states by federal law under the Endangered Species Act ESA. The refuge provides a habitat for 14 species federally listed as threatened or endangered, including the leatherback, green, Kemps Ridley, loggerhead and Atlantic hawksbill turtles. For information on the refuge, visit http://www.fws.gov/merrittisland/Index.html. For more information on the gopher tortoise, visit http://www.fws.gov/northflorida/GopherTortoise/Gopher_Tortoise_Fact_Sheet.html. Photo credit: NASA/Daniel Casper

KSC-2012-4861

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2014-2917

NASA Image and Video Library

2014-06-13

CAPE CANAVERAL, Fla. -- This gopher tortoise almost seems to float above the pavement as it hastens along the road at NASA's Kennedy Space Center in Florida. Gopher tortoises are dry-land turtles that live in scrub, dry hammock, pine flatwood, coastal grassland and dune habitats. The undeveloped property on Kennedy Space Center is managed by the U.S. Fish and Wildlife Service through the Merritt Island National Wildlife Refuge. Currently, gopher tortoises are protected in some states by federal law under the Endangered Species Act ESA. The refuge provides a habitat for 14 species federally listed as threatened or endangered, including the leatherback, green, Kemps Ridley, loggerhead and Atlantic hawksbill turtles. For information on the refuge, visit http://www.fws.gov/merrittisland/Index.html. For more information on the gopher tortoise, visit http://www.fws.gov/northflorida/GopherTortoise/Gopher_Tortoise_Fact_Sheet.html. Photo credit: NASA/Daniel Casper

KSC-2012-4863

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4852

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Launch Pad 39A is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-05pd2344

NASA Image and Video Library

2005-10-07

KENNEDY SPACE CENTER, FLA. - A gopher tortoise makes its way down the hill behind the NASA KSC News Center. The sandy soils of Florida are prime habitat for the species, the only one in Florida. Gopher tortoises thrive in many of our ecosystems, pine-oak sandhills, oak hammocks, prairies, flatwoods and coastal dunes. This and other wildlife abound throughout KSC as it shares a boundary with the Merritt Island National Wildlife Refuge, home to some of the nation’s rarest and most unusual species of wildlife. The wildlife refuge is a habitat for more than 310 species of birds, 25 mammals, 117 fishes and 65 amphibians and reptiles. In addition, the Refuge supports 19 endangered or threatened wildlife species on Federal or State lists, more than any other single refuge in the U.S. Gopher tortoises are protected by law in Florida and are listed as a Species of Special Concern.

KSC-2012-4867

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4846

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Launch Pad 39A is seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4857

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Operations Support Building II, or OSBII, is seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4849

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, is seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4848

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, is seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4862

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Launch Complex 39 is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4853

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Launch Pad 39A is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4851

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Launch Pad 39A is seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2014-2851

NASA Image and Video Library

2014-06-04

CAPE CANAVERAL, Fla. -- Why did the gopher tortoise cross the road? To get to the other side of the Launch Pad 39B beach road on NASA's Kennedy Space Center in Florida, of course. Gopher tortoises are dry-land turtles that live in scrub, dry hammock, pine flatwood, coastal grassland and dune habitats. The undeveloped property on Kennedy Space Center is managed by the U.S. Fish and Wildlife Service through the Merritt Island National Wildlife Refuge. Currently, gopher tortoises are protected in some states by federal law under the Endangered Species Act ESA. The refuge provides a habitat for 14 species federally listed as threatened or endangered, including the leatherback, green, Kemps Ridley, loggerhead and Atlantic hawksbill turtles. For information on the refuge, visit http://www.fws.gov/merrittisland/Index.html. For more information on the gopher tortoise, visit http://www.fws.gov/northflorida/GopherTortoise/Gopher_Tortoise_Fact_Sheet.html. Photo credit: NASA/Daniel Casper

Surgical repair of pectus excavatum and carinatum.

PubMed

Robicsek, Francis; Watts, Larry T; Fokin, Alexander A

2009-01-01

The author discusses different forms of pectus deformities and presents appropriate surgical methods he developed for their correction. For pectus excavatum, the surgical technique includes conservative sub-perichondral resection of deformed costal cartilages and detachment of the xiphoid process. A transverse sternotomy is performed at the upper level of the deformed sternum, which is then bent forward. The corrected sternal position is secured by a "hammock" of synthetic mesh, spread behind the sternum, and attached to the respective cartilage remnants. The pectoralis muscles are then united presternally. The initial steps of pectus carinatum correction are similar to that of pectus excavatum. The sternum, however, is not freed of its environment. A length of 3-4 cm is resected from the distal sternum and the xiphoid process is reattached in the proper anatomical direction. Measures to correct different anatomical varieties, such as pouter pigeon breast, asymmetrical pectus excavatum, and carinatum, are discussed individually.

Electronic Portfolios: Blending Technology, Accountability & Assessment

ERIC Educational Resources Information Center

Ahn, June

2004-01-01

Many educators struggle to discover the proper assessment strategies for students. Systemic reform and the standards movement introduce clarity and accountability in assessing students. Though proven to be efficient, standardized assessment such as multiple-choice tests often turn teachers away as they may not align with their classroom practices…

FNL Scientists Introduce Concept That Could Help the Immune System Respond to Vaccines | Frederick National Laboratory for Cancer Research

Cancer.gov

Scientists have discovered an efficient and straightforward model to manipulate RNA nanoparticles, a new concept that could help trigger desirable activation of the immune system with vaccines and therapies. A multi-institutional team of researchers

Flexibility in Problem Solving: The Case of Equation Solving

ERIC Educational Resources Information Center

Star, Jon R.; Rittle-Johnson, Bethany

2008-01-01

A key learning outcome in problem-solving domains is the development of flexible knowledge, where learners know multiple strategies and adaptively choose efficient strategies. Two interventions hypothesized to improve flexibility in problem solving were experimentally evaluated: prompts to discover multiple strategies and direct instruction on…

A novel approach for discovering condition-specific correlations of gene expressions within biological pathways by using cloud computing technology.

PubMed

Chang, Tzu-Hao; Wu, Shih-Lin; Wang, Wei-Jen; Horng, Jorng-Tzong; Chang, Cheng-Wei

2014-01-01

Microarrays are widely used to assess gene expressions. Most microarray studies focus primarily on identifying differential gene expressions between conditions (e.g., cancer versus normal cells), for discovering the major factors that cause diseases. Because previous studies have not identified the correlations of differential gene expression between conditions, crucial but abnormal regulations that cause diseases might have been disregarded. This paper proposes an approach for discovering the condition-specific correlations of gene expressions within biological pathways. Because analyzing gene expression correlations is time consuming, an Apache Hadoop cloud computing platform was implemented. Three microarray data sets of breast cancer were collected from the Gene Expression Omnibus, and pathway information from the Kyoto Encyclopedia of Genes and Genomes was applied for discovering meaningful biological correlations. The results showed that adopting the Hadoop platform considerably decreased the computation time. Several correlations of differential gene expressions were discovered between the relapse and nonrelapse breast cancer samples, and most of them were involved in cancer regulation and cancer-related pathways. The results showed that breast cancer recurrence might be highly associated with the abnormal regulations of these gene pairs, rather than with their individual expression levels. The proposed method was computationally efficient and reliable, and stable results were obtained when different data sets were used. The proposed method is effective in identifying meaningful biological regulation patterns between conditions.

Technical and Tactical Aspects that Differentiate Winning and Losing Performances in Elite Male Karate Fighters.

PubMed

Vidranski, Tihomir; Sertić, Hrvoje; Jukić, Josefina

2015-07-01

The purpose of this research was to identify the fighters' technical and tactical activity indicators in order to determine indicator significance regarding situational efficiency and designation between winning and losing performances in a karate match. We scientifically observed a sample of 274 male contesters of 137 karate matches during the 2008 World Karate Championship in Tokyo. Each individual competitor was observed in maximum of three matches. The matches were recorded using a DVD camera in order to collect data for further analysis, and the sample was further described using 48 technical and tactical indicators of situational efficiency and match outcome variables. The obtained results indicate that a karate match is composed of 91% of non-scoring techniques and 9% of scoring techniques in the total technique frequency. On this basis a significant difference in the situational efficiency between the match winners and the losing contesters has been discovered. Those two groups of fighters exhibit a statistically significant difference (p<0.05) in 11 out of 21 observed variables of situational efficiency in the table of derived situational indicators. A prevalence of non-scoring techniques suggests that energy demand and technical and tactical requirements of a karate match are in the largest extent defined by non-scoring techniques. Therefore, it would be a grave mistake to disregard non-scoring karate techniques in any future situational efficiency studies. It has been discovered that the winners differ from the defeated contesters by a higher level of situational efficiency in their executed techniques, which incorporate versatility, biomechanical and structural complexity, topological diversity and a specific tactical concept of technique use in the attack phase.

[Research on resources chemistry of Chinese medicinal materials and resources recycling utilization ways and goals and tasks].

PubMed

Duan, Jin-ao; Su, Shu-lan; Guo, Sheng; Jiang, Shu; Liu, Pei; Yan, Hui; Qian, Da-wei; Zhu, Hua-xu; Tang, Yu-ping; Wu, Qi-nan

2015-09-01

The objects of research on the resources chemistry of Chinese medicinal materials (RCCMM) are promotion of efficient production, rational utilization and improving quality of CMM and natural products. The development of TCM cause depends on the efficient utilization and sustainable development of CMM, hinges on the technologies and methods for using and discovering medicinal biological resources, stand or fall on the extension of industy chains, detailed utilizaion of resource chemical components by multi-way, multi-level. All of these may help to the recycling utilization and sound development of RCMM. In this article, five respects were discussed to the RCCMM researches and resources recycling utilization ways and goals and tasks. First, based on the principle of resource scarcity, discovering or replacing CMM resources, protecting the rare or endangered species or resources. Second, based on the multifunctionality of CMM, realizing the value-added and value compensation, and promoting the utilization efficiency through systermatic and detailed exploitation and utilization. Third, based on the resource conservation and environment-friendly, reducing raw material consumption, lowering cost, promoting recycling utilization and elevating utilization efficiency. Fourth, based on the stratege of turning harm into good, using the invasive alien biological resources by multi-ways and enriching the medicial resources. Fifth, based on the method of structure modification of chemical components, exploring and enhancing the utility value of resouces chemical substances. These data should provide references and attention for improving the utilization efficiency, promoting the development of recycling economy, and changing the mode of economic growth of agriculture and industry of CMM fundamentally.

Evidence-Based Practice in Psychology among College Counseling Center Clinicians

ERIC Educational Resources Information Center

Cooper, Stewart E.; Benton, Sherry A.; Benton, Stephen L.; Phillips, Julia C.

2008-01-01

This empirically based study sought to discover factors underlying diverse sources of information used to inform therapy practice, perceived salience of sources of evidence for clinical practice, importance of common factors to therapy efficiency, and beliefs about evidence-based practice, particularly in the form of evidence-supported treatments…

Spatiotemporal Data Mining, Analysis, and Visualization of Human Activity Data

ERIC Educational Resources Information Center

Li, Xun

2012-01-01

This dissertation addresses the research challenge of developing efficient new methods for discovering useful patterns and knowledge in large volumes of electronically collected spatiotemporal activity data. I propose to analyze three types of such spatiotemporal activity data in a methodological framework that integrates spatial analysis, data…

Accountability Policies at Schools: A Study of Path Analysis

ERIC Educational Resources Information Center

Erdag, Coskun

2017-01-01

Turkey is now on its way to reforming compulsory education and having a more effective and efficient education system by creating more accountable schools. This research has been designed in a causative pattern to discover the effects of external academic performance pressures on school accountability policies and school accountability responses…

Argonne News Brief: Self-Healing Diamond-Like Carbon Coating Could Revolutionize Lubrication

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Argonne scientists discovered a technique to create a layer of diamond-like carbon on the surfaces between moving parts. This could change the future of lubrication—potentially making engines more efficient, more reliable, and even greener (by reducing heavy metal additives needed in engine oils.)

Cage-Fighting Bees: Can Aggressive Competition Increase Pollination Efficacy for an Oligolectic Native Bee?

USDA-ARS?s Scientific Manuscript database

Pollination efficacy of the oligolectic bee Ptilothrix bombiformis was measured as the number of pollen grains delivered to virgin Hibiscus stigmas. Such specialized bee foragers are often assumed to be highly efficient pollinators. Intriguingly, however, we discovered females fight over host blooms...

Connectionist Learning Procedures.

ERIC Educational Resources Information Center

Hinton, Geoffrey E.

A major goal of research on networks of neuron-like processing units is to discover efficient learning procedures that allow these networks to construct complex internal representations of their environment. The learning procedures must be capable of modifying the connection strengths in such a way that internal units which are not part of the…

Anaerobic thermophilic culture system

DOEpatents

Ljungdahl, Lars G.; Wiegel, Jurgen K. W.

1981-01-01

A mixed culture system of the newly discovered microorganism Thermoanaerobacter ethanolicus ATCC31550 and the microorganism Clostridium thermocellum ATCC31549 is described. In a mixed nutrient culture medium that contains cellulose, these microorganisms have been coupled and cultivated to efficiently ferment cellulose to produce recoverable quantities of ethanol under anaerobic, thermophilic conditions.

Do Local Contributions Affect the Efficacy of Public Primary Schools?

ERIC Educational Resources Information Center

Jimenez, Emmanuel; Paqueo, Vicente

1996-01-01

Uses cost, financial sources, and student achievement data from Philippine primary schools (financed primarily from central sources) to discover if financial decentralization leads to more efficient schools. Schools that rely more heavily on local sources (contributions from local school boards, municipal government, parent-teacher associations,…

An evolutionarily conserved RNase-based mechanism for repression of transcriptional positive autoregulation

PubMed Central

Wurtmann, Elisabeth J.; Ratushny, Alexander V.; Pan, Min; Beer, Karlyn D.; Aitchison, John D.; Baliga, Nitin S.

2014-01-01

Summary It is known that environmental context influences the degree of regulation at the transcriptional and post-transcriptional levels. However, the principles governing the differential usage and interplay of regulation at these two levels are not clear. Here, we show that the integration of transcriptional and post-transcriptional regulatory mechanisms in a characteristic network motif drives efficient environment-dependent state transitions. Through phenotypic screening, systems analysis, and rigorous experimental validation, we discovered an RNase (VNG2099C) in Halobacterium salinarum that is transcriptionally co-regulated with genes of the aerobic physiologic state but acts on transcripts of the anaerobic state. Through modeling and experimentation we show that this arrangement generates an efficient state-transition switch, within which RNase-repression of a transcriptional positive autoregulation (RPAR) loop is critical for shutting down ATP-consuming active potassium uptake to reserve energy required for salinity adaptation under aerobic, high potassium, or dark conditions. Subsequently, we discovered that many Escherichia coli operons with energy-associated functions are also putatively controlled by RPAR indicating that this network motif may have evolved independently in phylogenetically distant organisms. Thus, our data suggest that interplay of transcriptional and post-transcriptional regulation in the RPAR motifis a generalized principle for efficient environment-dependent state transitions across prokaryotes. PMID:24612392

LP-LPA: A link influence-based label propagation algorithm for discovering community structures in networks

NASA Astrophysics Data System (ADS)

Berahmand, Kamal; Bouyer, Asgarali

2018-03-01

Community detection is an essential approach for analyzing the structural and functional properties of complex networks. Although many community detection algorithms have been recently presented, most of them are weak and limited in different ways. Label Propagation Algorithm (LPA) is a well-known and efficient community detection technique which is characterized by the merits of nearly-linear running time and easy implementation. However, LPA has some significant problems such as instability, randomness, and monster community detection. In this paper, an algorithm, namely node’s label influence policy for label propagation algorithm (LP-LPA) was proposed for detecting efficient community structures. LP-LPA measures link strength value for edges and nodes’ label influence value for nodes in a new label propagation strategy with preference on link strength and for initial nodes selection, avoid of random behavior in tiebreak states, and efficient updating order and rule update. These procedures can sort out the randomness issue in an original LPA and stabilize the discovered communities in all runs of the same network. Experiments on synthetic networks and a wide range of real-world social networks indicated that the proposed method achieves significant accuracy and high stability. Indeed, it can obviously solve monster community problem with regard to detecting communities in networks.

Can We Predict Patient Wait Time?

PubMed

Pianykh, Oleg S; Rosenthal, Daniel I

2015-10-01

The importance of patient wait-time management and predictability can hardly be overestimated: For most hospitals, it is the patient queues that drive and define every bit of clinical workflow. The objective of this work was to study the predictability of patient wait time and identify its most influential predictors. To solve this problem, we developed a comprehensive list of 25 wait-related parameters, suggested in earlier work and observed in our own experiments. All parameters were chosen as derivable from a typical Hospital Information System dataset. The parameters were fed into several time-predicting models, and the best parameter subsets, discovered through exhaustive model search, were applied to a large sample of actual patient wait data. We were able to discover the most efficient wait-time prediction factors and models, such as the line-size models introduced in this work. Moreover, these models proved to be equally accurate and computationally efficient. Finally, the selected models were implemented in our patient waiting areas, displaying predicted wait times on the monitors located at the front desks. The limitations of these models are also discussed. Optimal regression models based on wait-line sizes can provide accurate and efficient predictions for patient wait time. Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Efficient discovery of overlapping communities in massive networks

PubMed Central

Gopalan, Prem K.; Blei, David M.

2013-01-01

Detecting overlapping communities is essential to analyzing and exploring natural networks such as social networks, biological networks, and citation networks. However, most existing approaches do not scale to the size of networks that we regularly observe in the real world. In this paper, we develop a scalable approach to community detection that discovers overlapping communities in massive real-world networks. Our approach is based on a Bayesian model of networks that allows nodes to participate in multiple communities, and a corresponding algorithm that naturally interleaves subsampling from the network and updating an estimate of its communities. We demonstrate how we can discover the hidden community structure of several real-world networks, including 3.7 million US patents, 575,000 physics articles from the arXiv preprint server, and 875,000 connected Web pages from the Internet. Furthermore, we demonstrate on large simulated networks that our algorithm accurately discovers the true community structure. This paper opens the door to using sophisticated statistical models to analyze massive networks. PMID:23950224

Screening individual hybridomas by microengraving to discover monoclonal antibodies

PubMed Central

Ogunniyi, Adebola O; Story, Craig M; Papa, Eliseo; Guillen, Eduardo; Love, J Christopher

2014-01-01

The demand for monoclonal antibodies (mAbs) in biomedical research is significant, but the current methodologies used to discover them are both lengthy and costly. Consequently, the diversity of antibodies available for any particular antigen remains limited. Microengraving is a soft lithographic technique that provides a rapid and efficient alternative for discovering new mAbs. This protocol describes how to use microengraving to screen mouse hybridomas to establish new cell lines producing unique mAbs. Single cells from a polyclonal population are isolated into an array of microscale wells (~105 cells per screen). The array is then used to print a protein microarray, where each element contains the antibodies captured from individual wells. The antibodies on the microarray are screened with antigens of interest, and mapped to the corresponding cells, which are then recovered from their microwells by micromanipulation. Screening and retrieval require approximately 1–3 d (9–12 d including the steps for preparing arrays of microwells). PMID:19528952

Powder from cedar heartwood affects oviposition behavior in Coleomegilla maculata: a ladybird native to the Americas

USDA-ARS?s Scientific Manuscript database

Introduction: Coleomegilla maculata is a predatory ladybird inhabiting ecosystems in North, Central, and South America. The aim of our research is to discover efficient, low-cost materials that boost oviposition in mass-reared C. maculata fed non-natural foods. We tested the hypothesis that eastern ...

Administrative Technology and the School Executive: Applying the Systems Approach to Educational Administration.

ERIC Educational Resources Information Center

Knezevich, Stephen J., Ed.

In this era of rapid social change, educational administrators have discovered that new approaches to problem solving and decision making are needed. Systems analysis could afford a promising approach to administrative problems by providing a number of systematic techniques designed to sharpen administrative decision making, enhance efficiency,…

Berkeley Lab - Materials Sciences Division

Science.gov Websites

demonstrated a way to make it work. New Discovery Could Improve Organic Solar Cell Performance MSD's Center for lead to gains in efficiency for organic solar cells Rob Ritchie featured in Nature Communications Discover Material Ideal for Smart Photovoltaic Windows ▲ New Discovery Could Improve Organic Solar Cell

ResStock - Targeting Energy and Cost Savings for U.S. Homes | NREL

Science.gov Websites

ResStock - Targeting Energy and Cost Savings for U.S. Homes Science and Technology Highlights Highlights in Research & Development ResStock - Targeting Energy and Cost Savings for U.S. Homes Key discovered $49 billion in potential annual utility bill savings through cost-effective energy efficiency

Guide to Financing EnergySmart Schools

ERIC Educational Resources Information Center

US Department of Energy, 2010

2010-01-01

By making a commitment to high-performance schools, many school districts are discovering that smart energy choices can have lasting benefits for their students, their communities, and the environment. An energy-efficient school district with 4,000 students could save as much as $160,000 a year in energy costs. Over 10 years, those savings can…

The search for red AGN with 2MASS

NASA Technical Reports Server (NTRS)

Cutri, R. M.; Nelson, B. O.; Kirkpatrick, J. D.; Huchra, J. P.; Smith, P. S.

2001-01-01

We present the results of a simple, highly efficient 2MASS color-based survey that has already discovered 140 previously unknown red AGN and QSOs. These objects are near-infrared-bright and relatively nearby; the media redshift of the sample is z=0.25, and all but two have z<0.7.

A survey of single nucleotide polymorphisms identified from whole-genome sequencing and their functional effect in the porcine genome

USDA-ARS?s Scientific Manuscript database

One of the key aims of livestock genetics and genomics research is to discover the genetic variants underlying economically important traits such as reproductive performance, feed efficiency, disease susceptibility, and product quality. Next generation sequencing has recently emerged as an economica...

Efficiently Exploring Multilevel Data with Recursive Partitioning

ERIC Educational Resources Information Center

Martin, Daniel P.; von Oertzen, Timo; Rimm-Kaufman, Sara E.

2015-01-01

There is an increasing number of datasets with many participants, variables, or both, in education and other fields that often deal with large, multilevel data structures. Once initial confirmatory hypotheses are exhausted, it can be difficult to determine how best to explore the dataset to discover hidden relationships that could help to inform…

Social Network Aided Plagiarism Detection

ERIC Educational Resources Information Center

Zrnec, Aljaž; Lavbic, Dejan

2017-01-01

The prevalence of different kinds of electronic devices and the volume of content on the Web have increased the amount of plagiarism, which is considered an unethical act. If we want to be efficient in the detection and prevention of these acts, we have to improve today's methods of discovering plagiarism. The paper presents a research study where…

Recombinant Newcastle disease virus Anhinga Strain (NDV/Anh-EGFP) for Hepatoma Therapy

USDA-ARS?s Scientific Manuscript database

Hepatocellular carcinoma remains one of the most common malignant tumors in the world. Newcastle disease virus (NDV) has been proved to be an efficient oncolytic agent. NDV tumor killing efficacy is not only depending on the NDV strain but the type of tumor targeted. It is significant to discover mo...

Human vaginal fluid contains exosomes that have an inhibitory effect on an early step of the HIV-1 life cycle.

PubMed

Smith, Johanna A; Daniel, Rene

2016-11-13

Vaginal transmission is crucial to the spread of HIV-1 around the world. It is not yet clear what type (s) of innate defenses against HIV-1 infection are present in the vagina. Here, we aimed to determine whether human vaginal fluid contains exosomes that may possess anti-HIV-1 activity. The exosomal fraction was isolated from samples of vaginal fluids. The presence of exosomes was confirmed by flow cytometry and western blotting. The newly discovered exosomes were tested for their ability to block early steps of HIV-1 infection in vitro using established cell culture systems and real time PCR-based methods. Vaginal fluid contains exosomes expressing CD9, CD63, and CD81 exosomal markers. The exosomal fraction of the fluid-reduced transmission of HIV-1 vectors by 60%, the efficiency of reverse transcription step by 58.4%, and the efficiency of integration by 47%. Exosomes had no effect on the entry of HIV-1 vectors. Human vaginal fluid exosomes are newly discovered female innate defenses that may protect women against HIV-1 infection.

Measures of node centrality in mobile social networks

NASA Astrophysics Data System (ADS)

Gao, Zhenxiang; Shi, Yan; Chen, Shanzhi

2015-02-01

Mobile social networks exploit human mobility and consequent device-to-device contact to opportunistically create data paths over time. While links in mobile social networks are time-varied and strongly impacted by human mobility, discovering influential nodes is one of the important issues for efficient information propagation in mobile social networks. Although traditional centrality definitions give metrics to identify the nodes with central positions in static binary networks, they cannot effectively identify the influential nodes for information propagation in mobile social networks. In this paper, we address the problems of discovering the influential nodes in mobile social networks. We first use the temporal evolution graph model which can more accurately capture the topology dynamics of the mobile social network over time. Based on the model, we explore human social relations and mobility patterns to redefine three common centrality metrics: degree centrality, closeness centrality and betweenness centrality. We then employ empirical traces to evaluate the benefits of the proposed centrality metrics, and discuss the predictability of nodes' global centrality ranking by nodes' local centrality ranking. Results demonstrate the efficiency of the proposed centrality metrics.

SPLASH: structural pattern localization analysis by sequential histograms.

PubMed

Califano, A

2000-04-01

The discovery of sparse amino acid patterns that match repeatedly in a set of protein sequences is an important problem in computational biology. Statistically significant patterns, that is patterns that occur more frequently than expected, may identify regions that have been preserved by evolution and which may therefore play a key functional or structural role. Sparseness can be important because a handful of non-contiguous residues may play a key role, while others, in between, may be changed without significant loss of function or structure. Similar arguments may be applied to conserved DNA patterns. Available sparse pattern discovery algorithms are either inefficient or impose limitations on the type of patterns that can be discovered. This paper introduces a deterministic pattern discovery algorithm, called Splash, which can find sparse amino or nucleic acid patterns matching identically or similarly in a set of protein or DNA sequences. Sparse patterns of any length, up to the size of the input sequence, can be discovered without significant loss in performances. Splash is extremely efficient and embarrassingly parallel by nature. Large databases, such as a complete genome or the non-redundant SWISS-PROT database can be processed in a few hours on a typical workstation. Alternatively, a protein family or superfamily, with low overall homology, can be analyzed to discover common functional or structural signatures. Some examples of biologically interesting motifs discovered by Splash are reported for the histone I and for the G-Protein Coupled Receptor families. Due to its efficiency, Splash can be used to systematically and exhaustively identify conserved regions in protein family sets. These can then be used to build accurate and sensitive PSSM or HMM models for sequence analysis. Splash is available to non-commercial research centers upon request, conditional on the signing of a test field agreement. acal@us.ibm.com, Splash main page http://www.research.ibm.com/splash

Efficient mutation identification in zebrafish by microarray capturing and next generation sequencing.

PubMed

Bontems, Franck; Baerlocher, Loic; Mehenni, Sabrina; Bahechar, Ilham; Farinelli, Laurent; Dosch, Roland

2011-02-18

Fish models like medaka, stickleback or zebrafish provide a valuable resource to study vertebrate genes. However, finding genetic variants e.g. mutations in the genome is still arduous. Here we used a combination of microarray capturing and next generation sequencing to identify the affected gene in the mozartkugelp11cv (mzlp11cv) mutant zebrafish. We discovered a 31-bp deletion in macf1 demonstrating the potential of this technique to efficiently isolate mutations in a vertebrate genome. Copyright © 2011 Elsevier Inc. All rights reserved.

Energy-Efficient Systems Eliminate Icing Danger for UAVs

NASA Technical Reports Server (NTRS)

2010-01-01

Ames Research Center engineer Leonard Haslim invented an anti-icing t echnology called an electroexpulsive separation system, which uses m echanical force to shatter potentially dangerous ice buildup on an ai rcraft surface. Temecula, California-based Ice Management Systems (no w known as IMS-ESS) licensed the technology from Ames and has discov ered a niche market for the lightweight, energy-efficient technology: unmanned aerial vehicles (UAVs). IMS-ESS systems now prevent damagi ng ice accumulation on military UAVs, allowing the vehicles to carry out crucial missions year round.

Secure and Efficient Regression Analysis Using a Hybrid Cryptographic Framework: Development and Evaluation

PubMed Central

Jiang, Xiaoqian; Aziz, Md Momin Al; Wang, Shuang; Mohammed, Noman

2018-01-01

Background Machine learning is an effective data-driven tool that is being widely used to extract valuable patterns and insights from data. Specifically, predictive machine learning models are very important in health care for clinical data analysis. The machine learning algorithms that generate predictive models often require pooling data from different sources to discover statistical patterns or correlations among different attributes of the input data. The primary challenge is to fulfill one major objective: preserving the privacy of individuals while discovering knowledge from data. Objective Our objective was to develop a hybrid cryptographic framework for performing regression analysis over distributed data in a secure and efficient way. Methods Existing secure computation schemes are not suitable for processing the large-scale data that are used in cutting-edge machine learning applications. We designed, developed, and evaluated a hybrid cryptographic framework, which can securely perform regression analysis, a fundamental machine learning algorithm using somewhat homomorphic encryption and a newly introduced secure hardware component of Intel Software Guard Extensions (Intel SGX) to ensure both privacy and efficiency at the same time. Results Experimental results demonstrate that our proposed method provides a better trade-off in terms of security and efficiency than solely secure hardware-based methods. Besides, there is no approximation error. Computed model parameters are exactly similar to plaintext results. Conclusions To the best of our knowledge, this kind of secure computation model using a hybrid cryptographic framework, which leverages both somewhat homomorphic encryption and Intel SGX, is not proposed or evaluated to this date. Our proposed framework ensures data security and computational efficiency at the same time. PMID:29506966

Secure and Efficient Regression Analysis Using a Hybrid Cryptographic Framework: Development and Evaluation.

PubMed

Sadat, Md Nazmus; Jiang, Xiaoqian; Aziz, Md Momin Al; Wang, Shuang; Mohammed, Noman

2018-03-05

Machine learning is an effective data-driven tool that is being widely used to extract valuable patterns and insights from data. Specifically, predictive machine learning models are very important in health care for clinical data analysis. The machine learning algorithms that generate predictive models often require pooling data from different sources to discover statistical patterns or correlations among different attributes of the input data. The primary challenge is to fulfill one major objective: preserving the privacy of individuals while discovering knowledge from data. Our objective was to develop a hybrid cryptographic framework for performing regression analysis over distributed data in a secure and efficient way. Existing secure computation schemes are not suitable for processing the large-scale data that are used in cutting-edge machine learning applications. We designed, developed, and evaluated a hybrid cryptographic framework, which can securely perform regression analysis, a fundamental machine learning algorithm using somewhat homomorphic encryption and a newly introduced secure hardware component of Intel Software Guard Extensions (Intel SGX) to ensure both privacy and efficiency at the same time. Experimental results demonstrate that our proposed method provides a better trade-off in terms of security and efficiency than solely secure hardware-based methods. Besides, there is no approximation error. Computed model parameters are exactly similar to plaintext results. To the best of our knowledge, this kind of secure computation model using a hybrid cryptographic framework, which leverages both somewhat homomorphic encryption and Intel SGX, is not proposed or evaluated to this date. Our proposed framework ensures data security and computational efficiency at the same time. ©Md Nazmus Sadat, Xiaoqian Jiang, Md Momin Al Aziz, Shuang Wang, Noman Mohammed. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 05.03.2018.

Discovery and characterization of a highly efficient enantioselective mandelonitrile hydrolase from Burkholderia cenocepacia J2315 by phylogeny-based enzymatic substrate specificity prediction.

PubMed

Wang, Hualei; Sun, Huihui; Wei, Dongzhi

2013-02-18

A nitrilase-mediated pathway has significant advantages in the production of optically pure (R)-(-)-mandelic acid. However, unwanted byproduct, low enantioselectivity, and specific activity reduce its value in practical applications. An ideal nitrilase that can efficiently hydrolyze mandelonitrile to optically pure (R)-(-)-mandelic acid without the unwanted byproduct is needed. A novel nitrilase (BCJ2315) was discovered from Burkholderia cenocepacia J2315 through phylogeny-based enzymatic substrate specificity prediction (PESSP). This nitrilase is a mandelonitrile hydrolase that could efficiently hydrolyze mandelonitrile to (R)-(-)-mandelic acid, with a high enantiomeric excess of 98.4%. No byproduct was observed in this hydrolysis process. BCJ2315 showed the highest identity of 71% compared with other nitrilases in the amino acid sequence. BCJ2315 possessed the highest activity toward mandelonitrile and took mandelonitrile as the optimal substrate based on the analysis of substrate specificity. The kinetic parameters Vmax, Km, Kcat, and Kcat/Km toward mandelonitrile were 45.4 μmol/min/mg, 0.14 mM, 15.4 s(-1), and 1.1×10(5) M(-1)s(-1), respectively. The recombinant Escherichia coli M15/BCJ2315 had a strong substrate tolerance and could completely hydrolyze mandelonitrile (100 mM) with fewer amounts of wet cells (10 mg/ml) within 1 h. PESSP is an efficient method for discovering an ideal mandelonitrile hydrolase. BCJ2315 has high affinity and catalytic efficiency toward mandelonitrile. This nitrilase has great advantages in the production of optically pure (R)-(-)-mandelic acid because of its high activity and enantioselectivity, strong substrate tolerance, and having no unwanted byproduct. Thus, BCJ2315 has great potential in the practical production of optically pure (R)-(-)-mandelic acid in the industry.

Rapid one-step recombinational cloning

PubMed Central

Fu, Changlin; Wehr, Daniel R.; Edwards, Janice; Hauge, Brian

2008-01-01

As an increasing number of genes and open reading frames of unknown function are discovered, expression of the encoded proteins is critical toward establishing function. Accordingly, there is an increased need for highly efficient, high-fidelity methods for directional cloning. Among the available methods, site-specific recombination-based cloning techniques, which eliminate the use of restriction endonucleases and ligase, have been widely used for high-throughput (HTP) procedures. We have developed a recombination cloning method, which uses truncated recombination sites to clone PCR products directly into destination/expression vectors, thereby bypassing the requirement for first producing an entry clone. Cloning efficiencies in excess of 80% are obtained providing a highly efficient method for directional HTP cloning. PMID:18424799

Discovery of novel bacterial RNA polymerase inhibitors: pharmacophore-based virtual screening and hit optimization.

PubMed

Hinsberger, Stefan; Hüsecken, Kristina; Groh, Matthias; Negri, Matthias; Haupenthal, Jörg; Hartmann, Rolf W

2013-11-14

The bacterial RNA polymerase (RNAP) is a validated target for broad spectrum antibiotics. However, the efficiency of drugs is reduced by resistance. To discover novel RNAP inhibitors, a pharmacophore based on the alignment of described inhibitors was used for virtual screening. In an optimization process of hit compounds, novel derivatives with improved in vitro potency were discovered. Investigations concerning the molecular mechanism of RNAP inhibition reveal that they prevent the protein-protein interaction (PPI) between σ(70) and the RNAP core enzyme. Besides of reducing RNA formation, the inhibitors were shown to interfere with bacterial lipid biosynthesis. The compounds were active against Gram-positive pathogens and revealed significantly lower resistance frequencies compared to clinically used rifampicin.

Entropic anomaly and maximal efficiency of microscopic heat engines.

PubMed

Bo, Stefano; Celani, Antonio

2013-05-01

The efficiency of microscopic heat engines in a thermally heterogenous environment is considered. We show that-as a consequence of the recently discovered entropic anomaly-quasistatic engines, whose efficiency is maximal in a fluid at uniform temperature, have in fact vanishing efficiency in the presence of temperature gradients. For slow cycles the efficiency falls off as the inverse of the period. The maximum efficiency is reached at a finite value of the cycle period that is inversely proportional to the square root of the gradient intensity. The relative loss in maximal efficiency with respect to the thermally homogeneous case grows as the square root of the gradient. As an illustration of these general results, we construct an explicit, analytically solvable example of a Carnot stochastic engine. In this thought experiment, a Brownian particle is confined by a harmonic trap and immersed in a fluid with a linear temperature profile. This example may serve as a template for the design of real experiments in which the effect of the entropic anomaly can be measured.

Visualizing frequent patterns in large multivariate time series

NASA Astrophysics Data System (ADS)

Hao, M.; Marwah, M.; Janetzko, H.; Sharma, R.; Keim, D. A.; Dayal, U.; Patnaik, D.; Ramakrishnan, N.

2011-01-01

The detection of previously unknown, frequently occurring patterns in time series, often called motifs, has been recognized as an important task. However, it is difficult to discover and visualize these motifs as their numbers increase, especially in large multivariate time series. To find frequent motifs, we use several temporal data mining and event encoding techniques to cluster and convert a multivariate time series to a sequence of events. Then we quantify the efficiency of the discovered motifs by linking them with a performance metric. To visualize frequent patterns in a large time series with potentially hundreds of nested motifs on a single display, we introduce three novel visual analytics methods: (1) motif layout, using colored rectangles for visualizing the occurrences and hierarchical relationships of motifs in a multivariate time series, (2) motif distortion, for enlarging or shrinking motifs as appropriate for easy analysis and (3) motif merging, to combine a number of identical adjacent motif instances without cluttering the display. Analysts can interactively optimize the degree of distortion and merging to get the best possible view. A specific motif (e.g., the most efficient or least efficient motif) can be quickly detected from a large time series for further investigation. We have applied these methods to two real-world data sets: data center cooling and oil well production. The results provide important new insights into the recurring patterns.

Supernova Cosmology Project

Science.gov Websites

Supernova Survey: An Intensive HST Survey for z>1 Type Ia Supernovae by Targeting Galaxy Clusters Survey new survey strategy to discover and study high redshift Type Ia supernovae (SNe Ia) using the Hubble improvement in the efficiency of finding SNe compared to an HST field survey and a factor of three improvement

Visualization of Concurrent Program Executions

NASA Technical Reports Server (NTRS)

Artho, Cyrille; Havelund, Klaus; Honiden, Shinichi

2007-01-01

Various program analysis techniques are efficient at discovering failures and properties. However, it is often difficult to evaluate results, such as program traces. This calls for abstraction and visualization tools. We propose an approach based on UML sequence diagrams, addressing shortcomings of such diagrams for concurrency. The resulting visualization is expressive and provides all the necessary information at a glance.

Predictive Cache Modeling and Analysis

DTIC Science & Technology

2011-11-01

metaheuristic /bin-packing algorithm to optimize task placement based on task communication characterization. Our previous work on task allocation showed...Cache Miss Minimization Technology To efficiently explore combinations and discover nearly-optimal task-assignment algorithms , we extended to our...it was possible to use our algorithmic techniques to decrease network bandwidth consumption by ~25%. In this effort, we adapted these existing

Mechanophores for Self-Healing Applications

DTIC Science & Technology

2013-09-09

macroscopic failure. One of the first discovered mechanochemical reactions was the self - healing of vulcanized rubber . Damaging mechanical force...therefore have potential self - healing features. Using the serendipitous case of rubber as a model, mechanophores that produce reactive species under...Mechanophores for Self - Healing Applications Supramolecular polymers held together by hydrogen bonds make efficient self - healing systems. A rubber -like polymer

Implementation and Use of Simulated Students for Test and Validation of New Adaptive Educational Systems: A Practical Insight

ERIC Educational Resources Information Center

Dorça, Fabiano

2015-01-01

Studies attest that learning is facilitated if teaching strategies are in accordance with students learning styles, making learning process more effective and considerably improving students performances. In this context, one major research point--and a challenge--is to efficiently discover students' learning styles. But, the test and validation…

Discover NREL | NREL

Science.gov Websites

to the most energy-efficient data center in the world. Learn more. Our People Our employees embody conscientious people, meet some NRELians. The team of people here are constantly pushing me. They're some of the most intelligent and passionate people I've ever worked with, and they encourage me every day to be my

Development of steel design details and selection criteria for cost effective and innovative steel bridges in Colorado : CDOT study no. 85-00 final report.

DOT National Transportation Integrated Search

2011-07-01

This research focuses on finding a method for creating cost effective and innovative steel bridges in Colorado. The design method that was discovered to create this cost efficiency was designing the beams as simply supported for non-composite dead lo...

Investigating Alternatives to the Fish Early Life-Stage Test: A Strategy for Discovering and Annotating Adverse Outcome Pathways for Early Fish Development

EPA Science Inventory

The fish early life-stage (FELS) test (OECD Test Guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs. As part of an on-going effort to develop efficient and cost-effec...

Solving search problems by strongly simulating quantum circuits

PubMed Central

Johnson, T. H.; Biamonte, J. D.; Clark, S. R.; Jaksch, D.

2013-01-01

Simulating quantum circuits using classical computers lets us analyse the inner workings of quantum algorithms. The most complete type of simulation, strong simulation, is believed to be generally inefficient. Nevertheless, several efficient strong simulation techniques are known for restricted families of quantum circuits and we develop an additional technique in this article. Further, we show that strong simulation algorithms perform another fundamental task: solving search problems. Efficient strong simulation techniques allow solutions to a class of search problems to be counted and found efficiently. This enhances the utility of strong simulation methods, known or yet to be discovered, and extends the class of search problems known to be efficiently simulable. Relating strong simulation to search problems also bounds the computational power of efficiently strongly simulable circuits; if they could solve all problems in P this would imply that all problems in NP and #P could be solved in polynomial time. PMID:23390585

Better cancer biomarker discovery through better study design.

PubMed

Rundle, Andrew; Ahsan, Habibul; Vineis, Paolo

2012-12-01

High-throughput laboratory technologies coupled with sophisticated bioinformatics algorithms have tremendous potential for discovering novel biomarkers, or profiles of biomarkers, that could serve as predictors of disease risk, response to treatment or prognosis. We discuss methodological issues in wedding high-throughput approaches for biomarker discovery with the case-control study designs typically used in biomarker discovery studies, especially focusing on nested case-control designs. We review principles for nested case-control study design in relation to biomarker discovery studies and describe how the efficiency of biomarker discovery can be effected by study design choices. We develop a simulated prostate cancer cohort data set and a series of biomarker discovery case-control studies nested within the cohort to illustrate how study design choices can influence biomarker discovery process. Common elements of nested case-control design, incidence density sampling and matching of controls to cases are not typically factored correctly into biomarker discovery analyses, inducing bias in the discovery process. We illustrate how incidence density sampling and matching of controls to cases reduce the apparent specificity of truly valid biomarkers 'discovered' in a nested case-control study. We also propose and demonstrate a new case-control matching protocol, we call 'antimatching', that improves the efficiency of biomarker discovery studies. For a valid, but as yet undiscovered, biomarker(s) disjunctions between correctly designed epidemiologic studies and the practice of biomarker discovery reduce the likelihood that true biomarker(s) will be discovered and increases the false-positive discovery rate. © 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.

Experimental and simulation studies of neutron-induced single-event burnout in SiC power diodes

NASA Astrophysics Data System (ADS)

Shoji, Tomoyuki; Nishida, Shuichi; Hamada, Kimimori; Tadano, Hiroshi

2014-01-01

Neutron-induced single-event burnouts (SEBs) of silicon carbide (SiC) power diodes have been investigated by white neutron irradiation experiments and transient device simulations. It was confirmed that a rapid increase in lattice temperature leads to formation of crown-shaped aluminum and cracks inside the device owing to expansion stress when the maximum lattice temperature reaches the sublimation temperature. SEB device simulation indicated that the peak lattice temperature is located in the vicinity of the n-/n+ interface and anode contact, and that the positions correspond to a hammock-like electric field distribution caused by the space charge effect. Moreover, the locations of the simulated peak lattice temperature agree closely with the positions of the observed destruction traces. Furthermore, it was theoretically demonstrated that the period of temperature increase of a SiC power device is two orders of magnitude less than that of a Si power device, using a thermal diffusion equation.

A sandpiper wades in the water at KSC

NASA Technical Reports Server (NTRS)

1999-01-01

A sandpiper wades the water in the Merritt Island National Wildlife Refuge, which shares a boundary with the space center. Sandpipers are usually seen foraging on the beach or margins of lakes, ponds, marshes or streams. The open waters of the Wildlife Refuge provide wintering areas for 23 species of migratory waterfowl as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds. The refuge comprises 92,000 acres, ranging from fresh-water impoundments, salt-water estuaries and brackish marshes to hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators.

Flora and threatened and endangered plants of John F. Kennedy Space Center, Florida

NASA Technical Reports Server (NTRS)

Schmalzer, Paul A.; Hinkle, C. Ross

1990-01-01

The vascular flora of the Kennedy Space Center (KSC) area was first studied in the 1970's. Nomenclatural and taxonomic changes as well as additional collections required revision of this list. The revised list includes 1045 taxa of which 850 are native and 195 are introduced. This appears to be a substantial proportion of the regional flora. Forty six taxa are endemic or nearly endemic to Florida, a level of endemism that appears high for the east coast of central Florida. Seventy three taxa (69 native) are listed as threatened, endangered, or of special concern on Federal or state lists. Taxa of special concern occur in all major habitats, but many are restricted to hammocks and hardwood swamps that constitute a minor proportion of the terrestrial vegetation. For some of these taxa, populations on KSC appear to be important for their regional and global survival. The bryophyte flora of the KSC area include 23 mosses and 20 liverworts and hornworts. The lichen flora is currently unknown.

KSC-99pc65

NASA Image and Video Library

1999-01-14

KENNEDY SPACE CENTER, FLA. -- A pintail duck swims calmly in the waters of the Merritt Island National Wildlife Refuge, which shares a boundary with the space center. The pintail can be found in marshes, prairie ponds and tundra, and salt marshes in winter. They range from Alaska and Greenland south to Central America and the West Indies. The open waters of the Wildlife Refuge provide wintering areas for 23 species of migratory waterfowl as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds. The refuge comprises 92,000 acres, ranging from fresh-water impoundments, salt-water estuaries and brackish marshes to hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators

KSC-2012-4870

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Cape Canaveral Air Force Station's Solid Motor Assembly Building, or SMAB, is seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4845

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Aquatic biologists Eric Reyier, left, and Doug Scheidt with Innovative Health Applications, or IHA, prepare for a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4879

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Roy D. Bridges Jr. Bridge connecting NASA Kennedy Space Center's Industrial Area to Cape Canaveral Air Force Station's Industrial Area is seen during a field-guided boat tour. As part of the Kennedy's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of the center and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4878

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A boat dock and the Roy D. Bridges Jr. Bridge connecting NASA Kennedy Space Center's Industrial Area to Cape Canaveral Air Force Station's Industrial Area are seen during a field-guided boat tour. As part of the Kennedy's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of the center and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4858

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Operations Support Building II, or OSBII, left, and the Vehicle Assembly Building, or VAB, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4873

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Cape Canaveral Air Force Station's Solid Motor Assembly Building, or SMAB, and Launch Complex 37 are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4869

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Aquatic biologists Doug Scheidt, left, and Eric Reyier with Innovative Health Applications, or IHA, lead a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4876

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Roy D. Bridges Jr. Bridge connecting NASA Kennedy Space Center's Industrial Area to Cape Canaveral Air Force Station's Industrial Area is seen during a field-guided boat tour. As part of the Kennedy's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of the center and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4871

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A manatee splashes in the Banana River during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. Manatees are one of the many threatened or endangered species that call the refuge home. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4880

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A boat dock and skiff boat are seen near the Roy D. Bridges Jr. Bridge that connects NASA Kennedy Space Center's Industrial Area to Cape Canaveral Air Force Station's Industrial Area following a field-guided boat tour. As part of the Kennedy's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of the center and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4875

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Cape Canaveral Air Force Station's Launch Complex 37 and the Atlas V Operations Center, or ASOC, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4850

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Aquatic biologist Eric Reyier with Innovative Health Applications, or IHA, drives a skiff boat during a field-guided tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. Aquatic biologist Doug Scheidt searches for landmarks and wildlife during the tour. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4866

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The NASA News Center and Operations Support Building II, or OSBII, in Launch Complex 39 are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4877

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Roy D. Bridges Jr. Bridge connecting NASA Kennedy Space Center's Industrial Area to Cape Canaveral Air Force Station's Industrial Area is seen during a field-guided boat tour. As part of the Kennedy's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of the center and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4856

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Launch Pads 39A, right, and 39B, left, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4872

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A manatee swims in the Banana River during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. Manatees are one of the many threatened or endangered species that call the refuge home. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4854

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Cape Canaveral Air Force Station's Space Launch Complex 41 and the Vertical Integration Facility, or VIF, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

ADH1B promotes mesothelial clearance and ovarian cancer infiltration.

PubMed

Gharpure, Kshipra M; Lara, Olivia D; Wen, Yunfei; Pradeep, Sunila; LaFargue, Chris; Ivan, Cristina; Rupaimoole, Rajesha; Hu, Wei; Mangala, Lingegowda S; Wu, Sherry Y; Nagaraja, Archana S; Baggerly, Keith; Sood, Anil K

2018-05-18

Primary debulking surgery followed by adjuvant chemotherapy is the standard treatment for ovarian cancer. Residual disease after primary surgery is associated with poor patient outcome. Previously, we discovered ADH1B to be a molecular biomarker of residual disease. In the current study, we investigated the functional role of ADH1B in promoting ovarian cancer cell invasiveness and contributing to residual disease. We discovered that ADH1B overexpression leads to a more infiltrative cancer cell phenotype, promotes metastasis, increases the adhesion of cancer cells to mesothelial cells, and increases extracellular matrix degradation. Live cell imaging revealed that ADH1B-overexpressing cancer cells efficiently cleared the mesothelial cell layer compared to control cells. Moreover, gene array analysis revealed that ADH1B affects several pathways related to the migration and invasion of cancer cells. We also discovered that hypoxia increases ADH1B expression in ovarian cancer cells. Collectively, these findings indicate that ADH1B plays an important role in the pathways that promote ovarian cancer cell infiltration and may increase the likelihood of residual disease following surgery.

Speed and efficiency limits of multilevel incoherent heat engines.

PubMed

Mukherjee, V; Niedenzu, W; Kofman, A G; Kurizki, G

2016-12-01

We present a comprehensive theory of heat engines (HE) based on a quantum-mechanical "working fluid" (WF) with periodically modulated energy levels. The theory is valid for any periodicity of driving Hamiltonians that commute with themselves at all times and do not induce coherence in the WF. Continuous and stroke cycles arise in opposite limits of this theory, which encompasses hitherto unfamiliar cycle forms, dubbed here hybrid cycles. The theory allows us to discover the speed, power, and efficiency limits attainable by incoherently operating multilevel HE depending on the cycle form and the dynamical regimes.

Quantum Phenomena in High Energy Density Plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murnane, Margaret; Kapteyn, Henry

The possibility of implementing efficient (phase matched) HHG upconversion of deep- UV lasers in multiply-ionized plasmas, with potentially unprecedented conversion efficiency is a fascinating prospect. HHG results from the extreme nonlinear response of matter to intense laser light:high harmonics are radiated as a result of a quantum coherent electron recollision process that occurs during laser field ionization of an atom. Under current support from this grant in work published in Science in 2015, we discovered a new regime of bright HHG in highly-ionized plasmas driven by intense UV lasers, that generates bright harmonics to photon energies >280eV

Distributed Load Shedding over Directed Communication Networks with Time Delays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Tao; Wu, Di

When generation is insufficient to support all loads under emergencies, effective and efficient load shedding needs to be deployed in order to maintain the supply-demand balance. This paper presents a distributed load shedding algorithm, which makes efficient decision based on the discovered global information. In the global information discovery process, each load only communicates with its neighboring load via directed communication links possibly with arbitrarily large but bounded time varying communication delays. We propose a novel distributed information discovery algorithm based on ratio consensus. Simulation results are used to validate the proposed method.

Discovering System Health Anomalies Using Data Mining Techniques

NASA Technical Reports Server (NTRS)

Sriastava, Ashok, N.

2005-01-01

We present a data mining framework for the analysis and discovery of anomalies in high-dimensional time series of sensor measurements that would be found in an Integrated System Health Monitoring system. We specifically treat the problem of discovering anomalous features in the time series that may be indicative of a system anomaly, or in the case of a manned system, an anomaly due to the human. Identification of these anomalies is crucial to building stable, reusable, and cost-efficient systems. The framework consists of an analysis platform and new algorithms that can scale to thousands of sensor streams to discovers temporal anomalies. We discuss the mathematical framework that underlies the system and also describe in detail how this framework is general enough to encompass both discrete and continuous sensor measurements. We also describe a new set of data mining algorithms based on kernel methods and hidden Markov models that allow for the rapid assimilation, analysis, and discovery of system anomalies. We then describe the performance of the system on a real-world problem in the aircraft domain where we analyze the cockpit data from aircraft as well as data from the aircraft propulsion, control, and guidance systems. These data are discrete and continuous sensor measurements and are dealt with seamlessly in order to discover anomalous flights. We conclude with recommendations that describe the tradeoffs in building an integrated scalable platform for robust anomaly detection in ISHM applications.

Discovering graphical Granger causality using the truncating lasso penalty

PubMed Central

Shojaie, Ali; Michailidis, George

2010-01-01

Motivation: Components of biological systems interact with each other in order to carry out vital cell functions. Such information can be used to improve estimation and inference, and to obtain better insights into the underlying cellular mechanisms. Discovering regulatory interactions among genes is therefore an important problem in systems biology. Whole-genome expression data over time provides an opportunity to determine how the expression levels of genes are affected by changes in transcription levels of other genes, and can therefore be used to discover regulatory interactions among genes. Results: In this article, we propose a novel penalization method, called truncating lasso, for estimation of causal relationships from time-course gene expression data. The proposed penalty can correctly determine the order of the underlying time series, and improves the performance of the lasso-type estimators. Moreover, the resulting estimate provides information on the time lag between activation of transcription factors and their effects on regulated genes. We provide an efficient algorithm for estimation of model parameters, and show that the proposed method can consistently discover causal relationships in the large p, small n setting. The performance of the proposed model is evaluated favorably in simulated, as well as real, data examples. Availability: The proposed truncating lasso method is implemented in the R-package ‘grangerTlasso’ and is freely available at http://www.stat.lsa.umich.edu/∼shojaie/ Contact: shojaie@umich.edu PMID:20823316

Discovering How Students Search a University Web Site: A Comparative Usability Case Study for PC and Mobile Devices

ERIC Educational Resources Information Center

Sengel, Erhan

2014-01-01

This study aims to investigate the usability level of web site of a university by observing 10 participants who are required to complete 11 tasks, which have been defined by the researchers before to gather data about effectiveness, efficiency and satisfaction. System Usability Scale was used to collect data about satisfaction. The research…

Feasibility of Rescheduled School Year Plans for Delaware Public Elementary and Secondary Schools.

ERIC Educational Resources Information Center

Delaware State Dept. of Public Instruction, Dover.

A study team for the Delaware Department of Public Instruction sought to discover a rescheduled school year design that could be adopted and used to increase the efficiency of staff and school facilities in Delaware. Through a search of the literature, visits to three school districts, and a conference with a nationally recognized consultant,…

The Effects of University Mergers in China since 1990s: From the Perspective of Knowledge Production

ERIC Educational Resources Information Center

Mao, Ya-qing; Du, Yuan; Liu, Jing-juan

2009-01-01

Purpose: The purpose of this paper is to discover and better understand the efficiency of university mergers from the perspective of knowledge production, with the research capability as the point of contact. Design/methodology/approach: In total, 20 colleges and universities directly under the central ministries that merged in 2000 were taken as…

Group practices explore EDI options.

PubMed

McCormack, J

1999-04-01

Although physician groups have been relatively slow to take advantage of electronic commerce, more are discovering the benefits. Once group practice administrators get beyond their initial trepidation and realize that EDI is efficient, many are pleased with the results. And some are automating other transactions, including verifying patient eligibility for insurance coverage, gaining insurance authorization for referrals to specialists and checking the status of claims.

Magnetic-Flux-Compression Cooling Using Superconductors

NASA Technical Reports Server (NTRS)

Strayer, Donald M.; Israelsson, Ulf E.; Elleman, Daniel D.

1989-01-01

Proposed magnetic-flux-compression refrigeration system produces final-stage temperatures below 4.2 K. More efficient than mechanical and sorption refrigerators at temperatures in this range. Weighs less than comparable liquid-helium-cooled superconducting magnetic refrigeration systems operating below 4.2 K. Magnetic-flux-compression cooling stage combines advantages of newly discovered superconductors with those of cooling by magnetization and demagnetization of paramagnetic salts.

Using web-based technology to deliver scientific knowledge: the Southern Forest Encyclopedia Network.

Treesearch

John M. Pye; H. Michael Rauscher; Deborah K. Kennard; Patricia A. Flebbe; J. Bryan Jordin; William G. Hubbard; Cynthia Fowler; James Ward

2007-01-01

Forest science, like any science, is a continuous process of discovering new knowledge, reevaluating existing knowledge, and revising our theories and management practices in light of these changes. The forest science community has not yet found the solution to the problem of getting continuously changing science efficiently and effectively into the hands of those who...

Insurance and Annuity Plans for College Staffs. Bulletin, 1937, No. 5

ERIC Educational Resources Information Center

Flanagan, Sherman E.

1937-01-01

The efficiency and moral of members of college faculties are dependent in a large measure on an assurance of economic security. In order, that they may render a high standard of service in teaching youth and in discovering knowledge for the benefit of society, protection for them and their families against the risks and anxieties of the future is…

Hunt for improved carbon capture picks up speed

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

A high-throughput metal-organic framework synthesis instrument in action. Berkeley Lab chemist Jeffrey Long's lab will soon host a round-the-clock, robotically choreographed hunt for carbon-hungry materials. The Berkeley Lab chemist leads a diverse team of scientists whose goal is to quickly discover materials that can efficiently strip carbon dioxide from a power plant's exhaust, before it leaves the smokestack and contributes to climate change. They're betting on a recently discovered class of materials called metal-organic frameworks, which boast a record-shattering internal surface area. A sugar cube-sized piece, if unfolded and flattened, would more than blanket a football field. The crystalline materialmore » can also be tweaked to absorb specific molecules. More: http://newscenter.lbl.gov/feature-stories/2010/05/26/carbon-capture-search/« less

A Framework for the Evaluation of Biosecurity, Commercial, Regulatory, and Scientific Impacts of Plant Viruses and Viroids Identified by NGS Technologies

PubMed Central

Massart, Sebastien; Candresse, Thierry; Gil, José; Lacomme, Christophe; Predajna, Lukas; Ravnikar, Maja; Reynard, Jean-Sébastien; Rumbou, Artemis; Saldarelli, Pasquale; Škorić, Dijana; Vainio, Eeva J.; Valkonen, Jari P. T.; Vanderschuren, Hervé; Varveri, Christina; Wetzel, Thierry

2017-01-01

Recent advances in high-throughput sequencing technologies and bioinformatics have generated huge new opportunities for discovering and diagnosing plant viruses and viroids. Plant virology has undoubtedly benefited from these new methodologies, but at the same time, faces now substantial bottlenecks, namely the biological characterization of the newly discovered viruses and the analysis of their impact at the biosecurity, commercial, regulatory, and scientific levels. This paper proposes a scaled and progressive scientific framework for efficient biological characterization and risk assessment when a previously known or a new plant virus is detected by next generation sequencing (NGS) technologies. Four case studies are also presented to illustrate the need for such a framework, and to discuss the scenarios. PMID:28174561

SIX MORE QUASARS AT REDSHIFT 6 DISCOVERED BY THE CANADA-FRANCE HIGH-z QUASAR SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willott, Chris J.; Crampton, David; Hutchings, John B.

2009-03-15

We present imaging and spectroscopic observations for six quasars at z {>=} 5.9 discovered by the Canada-France High-z Quasar Survey (CFHQS). The CFHQS contains subsurveys with a range of flux and area combinations to sample a wide range of quasar luminosities at z {approx} 6. The new quasars have luminosities 10-75 times lower than the most luminous Sloan Digital Sky Survey quasars at this redshift. The least luminous quasar, CFHQS J0216-0455 at z = 6.01, has absolute magnitude M {sub 1450} = -22.21, well below the likely break in the luminosity function. This quasar is not detected in a deepmore » XMM-Newton survey showing that optical selection is still a very efficient tool for finding high-redshift quasars.« less

Interaction mining and skill-dependent recommendations for multi-objective team composition

PubMed Central

Dorn, Christoph; Skopik, Florian; Schall, Daniel; Dustdar, Schahram

2011-01-01

Web-based collaboration and virtual environments supported by various Web 2.0 concepts enable the application of numerous monitoring, mining and analysis tools to study human interactions and team formation processes. The composition of an effective team requires a balance between adequate skill fulfillment and sufficient team connectivity. The underlying interaction structure reflects social behavior and relations of individuals and determines to a large degree how well people can be expected to collaborate. In this paper we address an extended team formation problem that does not only require direct interactions to determine team connectivity but additionally uses implicit recommendations of collaboration partners to support even sparsely connected networks. We provide two heuristics based on Genetic Algorithms and Simulated Annealing for discovering efficient team configurations that yield the best trade-off between skill coverage and team connectivity. Our self-adjusting mechanism aims to discover the best combination of direct interactions and recommendations when deriving connectivity. We evaluate our approach based on multiple configurations of a simulated collaboration network that features close resemblance to real world expert networks. We demonstrate that our algorithm successfully identifies efficient team configurations even when removing up to 40% of experts from various social network configurations. PMID:22298939

Finding the rarest objects in the universe: A new, efficient method for discovering BL Lacertae objects

NASA Technical Reports Server (NTRS)

Stocke, John; Perlman, Eric; Granados, Arno; Schachter, Jonathan; Elvis, Martin; Urry, Meg; Impey, Chris; Smith, Paul

1993-01-01

We present a new, efficient method for discovering new BL Lac Objects based upon the results of the Einstein Extended Medium Sensitivity Survey (EMSS). We have found that all x-ray selected BL Lacs are radio emitters, and further, that in a 'color-color' diagram (radio/optical and optical/x-ray) the BL Lac Objects occupy an area distinct from both radio loud quasars and the radio quiet QSOs and Seyferts which dominate x-ray selected samples. After obtaining radio counterparts via VLA 'snapshot' observations of a large sample of unidentified x-ray sources, the list of candidates is reduced. These candidates then can be confirmed with optical spectroscopy and/or polarimetry. Since greater than 70 percent of these sources are expected to be BL Lacs, the optical observations are very efficient. We have tested this method using unidentified sources found in the Einstein Slew Survey. The 162 Slew Survey x-ray source positions were observed with the VLA in a mixed B/C configuration at 6 cm resulting in 60 detections within 1.5 position error circle radii. These x-ray/optical/radio sources were then plotted, and 40 BL Lac candidates were identified. To date, 10 candidates have been spectroscopically observed resulting in 10 new BL Lac objects! Radio flux, optical magnitude, and polarization statistics (obtained in white light with the Steward Observatory 2.3 m CCD polarimeter) for each are given.

A multiple-dimension liquid chromatography coupled with mass spectrometry data strategy for the rapid discovery and identification of unknown compounds from a Chinese herbal formula (Er-xian decoction).

PubMed

Wang, Caihong; Zhang, Jinlan; Wu, Caisheng; Wang, Zhe

2017-10-06

It is very important to rapidly discover and identify the multiple components of traditional Chinese medicine (TCM) formula. High performance liquid chromatography with high resolution tandem mass spectrometry (HPLC-HRMS/MS) has been widely used to analyze TCM formula and contains multiple-dimension data including retention time (RT), high resolution mass (HRMS), multiple-stage mass spectrometric (MS n ), and isotope intensity distribution (IID) data. So it is very necessary to exploit a useful strategy to utilize multiple-dimension data to rapidly probe structural information and identify chemical compounds. In this study, a new strategy to initiatively use the multiple-dimension LC-MS data has been developed to discover and identify unknown compounds of TCM in many styles. The strategy guarantees the fast discovery of candidate structural information and provides efficient structure clues for identification. The strategy contains four steps in sequence: (1) to discover potential compounds and obtain sub-structure information by the mass spectral tree similarity filter (MTSF) technique, based on HRMS and MS n data; (2) to classify potential compounds into known chemical classes by discriminant analysis (DA) on the basis of RT and HRMS data; (3) to hit the candidate structural information of compounds by intersection sub-structure between MTSF and DA (M,D-INSS); (4) to annotate and confirm candidate structures by IID data. This strategy allowed for the high exclusion efficiency (greater than 41%) of irrelevant ions in er-xian decoction (EXD) while providing accurate structural information of 553 potential compounds and identifying 66 candidates, therefore accelerating and simplifying the discovery and identification of unknown compounds in TCM formula. Copyright © 2017 Elsevier B.V. All rights reserved.

An upgraded bacterial surface display system to express cleavable capsid protein of human noroviruses: A novel system to discover candidate receptors for HuNoV

USDA-ARS?s Scientific Manuscript database

Human noroviruses (HuNoVs) are the dominant cause of food-borne outbreaks of gastroenteritis. However, the fundamental of the research on the viruses were restricted by the current immature system to culture HuNoVs and lacking of efficient small animal models. Previously, we demonstrated that the re...

Evaluation of the Effects of Head Start Experience in the Area of Self-Concept, Social Skills, and Language Skills. Pre-Publication Draft.

ERIC Educational Resources Information Center

McNamara, J. Regis; And Others

About 180 Negro Head Start children in Dade County, Florida, were tested (1) to discover if the county's program contributed significantly to language skills, social skills, and self-concept development and (2) to determine if an efficient instrument could be developed to measure self-concept in the disadvantaged child. Pretests and posttests used…

Changing the Culture of Fuel Efficiency: A Change in Attitude

DTIC Science & Technology

2014-05-09

2011 September). Organizational Culture: Assessment and Transformation. Journal of Change Management, 11(3), 305-328. Bandura , A. (1986). Social ...describes that, “organizational culture is a set of basic assumptions that a group has invented, discovered or developed in learning to cope with its...change. In the first category they found the most influential factors are leadership, attraction-selection-attrition, socialization , reward systems

Polymeric and Molecular Materials for Advanced Organic Electronics

DTIC Science & Technology

2011-07-25

printable variants. All have excellent dielectric and insulating properties, a remarkable ability to minimize trapped charge between thin film transistor... trapped charge density, and hence the corresponding OTFT device performance. Under this program we first discovered that OTFT performance is...deep, high- density charge traps must be overcome for efficient FET operation, it has been postulated that in most OFETs, shallow lower-density (~10

Capturing, Sharing, and Discovering Product Data at a Semantic Level--Moving Forward to the Semantic Web for Advancing the Engineering Product Design Process

ERIC Educational Resources Information Center

Zhu, Lijuan

2011-01-01

Along with the greater productivity that CAD automation provides nowadays, the product data of engineering applications needs to be shared and managed efficiently to gain a competitive edge for the engineering product design. However, exchanging and sharing the heterogeneous product data is still challenging. This dissertation first presents a…

Reliable Early Classification on Multivariate Time Series with Numerical and Categorical Attributes

DTIC Science & Technology

2015-05-22

design a procedure of feature extraction in REACT named MEG (Mining Equivalence classes with shapelet Generators) based on the concept of...Equivalence Classes Mining [12, 15]. MEG can efficiently and effectively generate the discriminative features. In addition, several strategies are proposed...technique of parallel computing [4] to propose a process of pa- rallel MEG for substantially reducing the computational overhead of discovering shapelet

Fast discovery and visualization of conserved regions in DNA sequences using quasi-alignment

PubMed Central

2013-01-01

Background Next Generation Sequencing techniques are producing enormous amounts of biological sequence data and analysis becomes a major computational problem. Currently, most analysis, especially the identification of conserved regions, relies heavily on Multiple Sequence Alignment and its various heuristics such as progressive alignment, whose run time grows with the square of the number and the length of the aligned sequences and requires significant computational resources. In this work, we present a method to efficiently discover regions of high similarity across multiple sequences without performing expensive sequence alignment. The method is based on approximating edit distance between segments of sequences using p-mer frequency counts. Then, efficient high-throughput data stream clustering is used to group highly similar segments into so called quasi-alignments. Quasi-alignments have numerous applications such as identifying species and their taxonomic class from sequences, comparing sequences for similarities, and, as in this paper, discovering conserved regions across related sequences. Results In this paper, we show that quasi-alignments can be used to discover highly similar segments across multiple sequences from related or different genomes efficiently and accurately. Experiments on a large number of unaligned 16S rRNA sequences obtained from the Greengenes database show that the method is able to identify conserved regions which agree with known hypervariable regions in 16S rRNA. Furthermore, the experiments show that the proposed method scales well for large data sets with a run time that grows only linearly with the number and length of sequences, whereas for existing multiple sequence alignment heuristics the run time grows super-linearly. Conclusion Quasi-alignment-based algorithms can detect highly similar regions and conserved areas across multiple sequences. Since the run time is linear and the sequences are converted into a compact clustering model, we are able to identify conserved regions fast or even interactively using a standard PC. Our method has many potential applications such as finding characteristic signature sequences for families of organisms and studying conserved and variable regions in, for example, 16S rRNA. PMID:24564200

Fast discovery and visualization of conserved regions in DNA sequences using quasi-alignment.

PubMed

Nagar, Anurag; Hahsler, Michael

2013-01-01

Next Generation Sequencing techniques are producing enormous amounts of biological sequence data and analysis becomes a major computational problem. Currently, most analysis, especially the identification of conserved regions, relies heavily on Multiple Sequence Alignment and its various heuristics such as progressive alignment, whose run time grows with the square of the number and the length of the aligned sequences and requires significant computational resources. In this work, we present a method to efficiently discover regions of high similarity across multiple sequences without performing expensive sequence alignment. The method is based on approximating edit distance between segments of sequences using p-mer frequency counts. Then, efficient high-throughput data stream clustering is used to group highly similar segments into so called quasi-alignments. Quasi-alignments have numerous applications such as identifying species and their taxonomic class from sequences, comparing sequences for similarities, and, as in this paper, discovering conserved regions across related sequences. In this paper, we show that quasi-alignments can be used to discover highly similar segments across multiple sequences from related or different genomes efficiently and accurately. Experiments on a large number of unaligned 16S rRNA sequences obtained from the Greengenes database show that the method is able to identify conserved regions which agree with known hypervariable regions in 16S rRNA. Furthermore, the experiments show that the proposed method scales well for large data sets with a run time that grows only linearly with the number and length of sequences, whereas for existing multiple sequence alignment heuristics the run time grows super-linearly. Quasi-alignment-based algorithms can detect highly similar regions and conserved areas across multiple sequences. Since the run time is linear and the sequences are converted into a compact clustering model, we are able to identify conserved regions fast or even interactively using a standard PC. Our method has many potential applications such as finding characteristic signature sequences for families of organisms and studying conserved and variable regions in, for example, 16S rRNA.

VISIR: technological infrastructure of an operational service for safe and efficient navigation in the Mediterranean Sea

NASA Astrophysics Data System (ADS)

Mannarini, Gianandrea; Turrisi, Giuseppe; D'Anca, Alessandro; Scalas, Mario; Pinardi, Nadia; Coppini, Giovanni; Palermo, Francesco; Carluccio, Ivano; Scuro, Matteo; Cretì, Sergio; Lecci, Rita; Nassisi, Paola; Tedesco, Luca

2016-08-01

VISIR (discoVerIng Safe and effIcient Routes) is an operational decision support system (DSS) for optimal ship routing designed and implemented in the frame of the TESSA (TEchnology for Situational Sea Awareness) project. The system is aimed to increase safety and efficiency of navigation through the use of forecast environmental fields and route optimization. VISIR can be accessed through a web interface (www.visir-nav.com) and mobile applications for both iOS and Android devices. This paper focuses on the technological infrastructure developed for operating VISIR as a DSS. Its main components are described, the performance of the operational system is assessed through experimental measurements, and a few case studies are presented.

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors

PubMed Central

Frett, Brendan; McConnell, Nick; Smith, Catherine C.; Wang, Yuanxiang; Shah, Neil P.; Li, Hong-yu

2015-01-01

The FLT3 kinase represents an attractive target to effectively treat AML. Unfortunately, no FLT3 targeted therapeutic is currently approved. In line with our continued interests in treating kinase related disease for anti-FLT3 mutant activity, we utilized pioneering synthetic methodology in combination with computer aided drug discovery and identified low molecular weight, highly ligand efficient, FLT3 kinase inhibitors. Compounds were analyzed for biochemical inhibition, their ability to selectively inhibit cell proliferation, for FLT3 mutant activity, and preliminary aqueous solubility. Validated hits were discovered that can serve as starting platforms for lead candidates. PMID:25765758

High Beginning-of-Life Efficiency p/n InP Solar Cells

NASA Technical Reports Server (NTRS)

Hoffman, Richard W., Jr.; Fatemi, Navid S.; Weizer, Victor G.; Jenkins, Phillip P.; Ringel, Steven A.; Scheiman, David A.; Wilt, David M.; Brinker, David J.

2004-01-01

We have achieved a new record efficiency of 17.6%, (AM0) for a p/n InP homo-epitaxy solar cell. In addition, we have eliminated a previously observed photo-degradation of cell performance, which was due to losses in J(sub sc). Cells soaked in AM0 spectrum at one-sun intensity for an hour showed no significant change in cell performance. We have discovered carrier passivation effects when using Zn as the p-type dopant in the OMVPE growth of InP and have found a method to avoid the unexpected effects which result from typical operation of OMVPE cell growth.

Strategy to discover diverse optimal molecules in the small molecule universe.

PubMed

Rupakheti, Chetan; Virshup, Aaron; Yang, Weitao; Beratan, David N

2015-03-23

The small molecule universe (SMU) is defined as a set of over 10(60) synthetically feasible organic molecules with molecular weight less than ∼500 Da. Exhaustive enumerations and evaluation of all SMU molecules for the purpose of discovering favorable structures is impossible. We take a stochastic approach and extend the ACSESS framework ( Virshup et al. J. Am. Chem. Soc. 2013 , 135 , 7296 - 7303 ) to develop diversity oriented molecular libraries that can generate a set of compounds that is representative of the small molecule universe and that also biases the library toward favorable physical property values. We show that the approach is efficient compared to exhaustive enumeration and to existing evolutionary algorithms for generating such libraries by testing in the NKp fitness landscape model and in the fully enumerated GDB-9 chemical universe containing 3 × 10(5) molecules.

Strategy To Discover Diverse Optimal Molecules in the Small Molecule Universe

PubMed Central

2015-01-01

The small molecule universe (SMU) is defined as a set of over 1060 synthetically feasible organic molecules with molecular weight less than ∼500 Da. Exhaustive enumerations and evaluation of all SMU molecules for the purpose of discovering favorable structures is impossible. We take a stochastic approach and extend the ACSESS framework (Virshup et al. J. Am. Chem. Soc.2013, 135, 7296–730323548177) to develop diversity oriented molecular libraries that can generate a set of compounds that is representative of the small molecule universe and that also biases the library toward favorable physical property values. We show that the approach is efficient compared to exhaustive enumeration and to existing evolutionary algorithms for generating such libraries by testing in the NKp fitness landscape model and in the fully enumerated GDB-9 chemical universe containing 3 × 105 molecules. PMID:25594586

Bit-Table Based Biclustering and Frequent Closed Itemset Mining in High-Dimensional Binary Data

PubMed Central

Király, András; Abonyi, János

2014-01-01

During the last decade various algorithms have been developed and proposed for discovering overlapping clusters in high-dimensional data. The two most prominent application fields in this research, proposed independently, are frequent itemset mining (developed for market basket data) and biclustering (applied to gene expression data analysis). The common limitation of both methodologies is the limited applicability for very large binary data sets. In this paper we propose a novel and efficient method to find both frequent closed itemsets and biclusters in high-dimensional binary data. The method is based on simple but very powerful matrix and vector multiplication approaches that ensure that all patterns can be discovered in a fast manner. The proposed algorithm has been implemented in the commonly used MATLAB environment and freely available for researchers. PMID:24616651

Collaborative mining of graph patterns from multiple sources

NASA Astrophysics Data System (ADS)

Levchuk, Georgiy; Colonna-Romanoa, John

2016-05-01

Intelligence analysts require automated tools to mine multi-source data, including answering queries, learning patterns of life, and discovering malicious or anomalous activities. Graph mining algorithms have recently attracted significant attention in intelligence community, because the text-derived knowledge can be efficiently represented as graphs of entities and relationships. However, graph mining models are limited to use-cases involving collocated data, and often make restrictive assumptions about the types of patterns that need to be discovered, the relationships between individual sources, and availability of accurate data segmentation. In this paper we present a model to learn the graph patterns from multiple relational data sources, when each source might have only a fragment (or subgraph) of the knowledge that needs to be discovered, and segmentation of data into training or testing instances is not available. Our model is based on distributed collaborative graph learning, and is effective in situations when the data is kept locally and cannot be moved to a centralized location. Our experiments show that proposed collaborative learning achieves learning quality better than aggregated centralized graph learning, and has learning time comparable to traditional distributed learning in which a knowledge of data segmentation is needed.

Enhanced photocatalytic performance of BiVO4 in aqueous AgNO3 solution under visible light irradiation

NASA Astrophysics Data System (ADS)

Huang, Chien-Kai; Wu, Tsunghsueh; Huang, Chang-Wei; Lai, Chi-Yung; Wu, Mei-Yao; Lin, Yang-Wei

2017-03-01

Monoclinic-phase bismuth vanadate (BiVO4) with a 2.468 eV band gap exhibited enhanced synergic photodegradation activity toward methylene blue (MB) when combined with silver ions (Ag+) in an aqueous solution under visible light irradiation. The mass ratio of AgNO3 to BiVO4 and the calcination temperature were discovered to considerably affect the degradation activity of BiVO4/Ag+. Superior photocatalytic performance was obtained when BiVO4 was mixed with 0.01%(w/v) AgNO3 solution, and complete degradation of MB was achieved after 25 min visible light irradiation, outperforming BiVO4 or AgNO3 solution alone. The enhanced photodegradation was investigated using systematic luminescence measurements, electrochemical impedance spectroscopy, and scavenger addition, after which a photocatalytic mechanism for MB degradation under visible light irradiation was identified that involved oxygen radicals and holes. This study also discovered the two dominating processes involved in enhancing the electron-hole separation efficiency and reducing their recombination rate, namely photoreduction of Ag+ and the formation of a BiVO4/Ag heterojunction. The synergic effect between BiVO4 and Ag+ was discovered to be unique. BiVO4/Ag+ was successfully used to degrade two other dyes and disinfect Escherichia Coli. A unique fluorescent technique using BiVO4 and a R6G solution to detect Ag+ ions in water was discovered.

Foundations of cumulative culture in apes: improved foraging efficiency through relinquishing and combining witnessed behaviours in chimpanzees (Pan troglodytes).

PubMed

Davis, Sarah J; Vale, Gillian L; Schapiro, Steven J; Lambeth, Susan P; Whiten, Andrew

2016-10-24

A vital prerequisite for cumulative culture, a phenomenon often asserted to be unique to humans, is the ability to modify behaviour and flexibly switch to more productive or efficient alternatives. Here, we first established an inefficient solution to a foraging task in five captive chimpanzee groups (N = 19). Three groups subsequently witnessed a conspecific using an alternative, more efficient, solution. When participants could successfully forage with their established behaviours, most individuals did not switch to this more efficient technique; however, when their foraging method became substantially less efficient, nine chimpanzees with socially-acquired information (four of whom witnessed additional human demonstrations) relinquished their old behaviour in favour of the more efficient one. Only a single chimpanzee in control groups, who had not witnessed a knowledgeable model, discovered this. Individuals who switched were later able to combine components of their two learned techniques to produce a more efficient solution than their extensively used, original foraging method. These results suggest that, although chimpanzees show a considerable degree of conservatism, they also have an ability to combine independent behaviours to produce efficient compound action sequences; one of the foundational abilities (or candidate mechanisms) for human cumulative culture.

High fat diet leads to changes in metabolite patterns in pig plasma, fecal, and urine samples detected by a ultra-high performance liquid chromatography tandem with high resolution mass spectrometry metabolomic study

USDA-ARS?s Scientific Manuscript database

Non-targeted metabolite profiling can identify robust biological markers of dietary exposure that can lead to a better understanding of causal interactions between diet and health. In this study, pigs were used as an animal model to develop an efficient procedure to discover metabolites in biolog...

Pharmaceutical marketing in a new age. Effective campaigns still need to focus on what customers want.

PubMed

Rao, Sanjay K

2002-01-01

The pharmaceutical industry has focused heavily on marketers' ability to market new products more efficiently. However, a more streamlined marketing approach can help address customers' needs and ease the pressure on drug companies to discover new drugs with blockbuster appeal. Through discussion and a detailed example, this article describes a stream-lined approach to creating more effective marketing and sales force strategies.

Discovering Social Circles in Ego Networks (Author’s Manuscript)

DTIC Science & Technology

2013-01-10

ego-network. We expect that circles are formed by densely-connected sets of alters ( Newman , 2006). However, different circles overlap heavily, i.e...umbrella of community detection (Lancichinetti and Fortunato, 2009a; Schaeffer, 2007; Leskovec et al., 2010; Porter et al., 2009; Newman , 2004). While...MCMC) sampler ( Newman and Barkema, 1999) which efficiently updates node-community memberships by ‘collapsing’ nodes that have common features and

Reducing the Bottleneck in Discovery of Novel Antibiotics.

PubMed

Jones, Marcus B; Nierman, William C; Shan, Yue; Frank, Bryan C; Spoering, Amy; Ling, Losee; Peoples, Aaron; Zullo, Ashley; Lewis, Kim; Nelson, Karen E

2017-04-01

Most antibiotics were discovered by screening soil actinomycetes, but the efficiency of the discovery platform collapsed in the 1960s. By now, more than 3000 antibiotics have been described and most of the current discovery effort is focused on the rediscovery of known compounds, making the approach impractical. The last marketed broad-spectrum antibiotics discovered were daptomycin, linezolid, and fidaxomicin. The current state of the art in the development of new anti-infectives is a non-existent pipeline in the absence of a discovery platform. This is particularly troubling given the emergence of pan-resistant pathogens. The current practice in dealing with the problem of the background of known compounds is to use chemical dereplication of extracts to assess the relative novelty of a compound it contains. Dereplication typically requires scale-up, extraction, and often fractionation before an accurate mass and structure can be produced by MS analysis in combination with 2D NMR. Here, we describe a transcriptome analysis approach using RNA sequencing (RNASeq) to identify promising novel antimicrobial compounds from microbial extracts. Our pipeline permits identification of antimicrobial compounds that produce distinct transcription profiles using unfractionated cell extracts. This efficient pipeline will eliminate the requirement for purification and structure determination of compounds from extracts and will facilitate high-throughput screen of cell extracts for identification of novel compounds.

TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.

PubMed

Ménager, Mickaël M

2017-06-15

Dendritic cells (DCs) have essential roles in early detection of pathogens and activation of both innate and adaptive immune responses. Whereas human DCs are resistant to productive HIV-1 replication, they have a unique ability to take up virus and transmit it efficiently to T lymphocytes. By doing that, HIV-1 may evade, at least in part, the first line of defense of the immune system, exploiting DCs instead to facilitate rapid infection of a large pool of immune cells. While performing an shRNA screen in human primary monocyte-derived DCs, to gain insights into this cell biological process, we discovered the role played by tetraspanin-7 (TSPAN7). This member of the tetraspanin family appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes. While studying the function of TSPAN7 in the control of actin nucleation, we also discovered the existence in DCs of two opposing forces at the plasma membrane: actin nucleation, a protrusive force which seems to counterbalance actomyosin contraction. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romm, J.J.

Many American companies have found that saving energy and cutting pollution dramatically improves the bottom line. But beyond these gains, businesses that launch energy efficiency programs to save money are often astonished to discover unforeseen benefits: energy efficient lighting, heating, cooling, motors, and industrial processes can increase worker productivity, decrease absenteeism, and improve the quality of work performed. Profits created by the jump in worker productivity can exceed energy savings by a factor of ten. Energy efficiency and pollution prevention represent the next wave in manufacturing, following the quality revolution launched by the Japanese in the 1960s. Unless America leadsmore » the lean and clean revolution, economic health will be undermined as other countries develop clean processes and products and US companies suffer competitively. Also, developing countries will leapfrog their wasteful model and buy products and manufacturing processes from foreign firms already practicing lean and clean.« less

Application of Mössbauer spectroscopy for: (1) characterization of Egyptian Maghara coal; (2) evaluating the efficiency of different methods for coal desulphurization

NASA Astrophysics Data System (ADS)

Eissa, N. A.; Sheta, N. H.; Ahmed, M. A.

1992-04-01

Coal has been recently discovered in Maghara mine at Northern Sinai, Egypt. Coal samples have been collected from different depths and were measured by XRD, XRF, and MS, in order to characterize this type of coal. It has been found that the iron bearing minerals are mainly pyrite and different sulphates depending on the depth of the sample. The second part contains the application of desulphurization techniques to Egyptian coal which are: floatation (one step and two steps) chemical [(HCl+HNO3), and Fe2(SO4)3] and bacterial methods (Chromatium and Chlorobium species). The efficiency of each technique was calculated. A comparative discussion is given of each desulphurization method, from which the bacterial method has proved to be the most efficient one.

Competitive interactions between a native spider (Frontinella communis, Araneae: Linyphiidae) and an invasive spider (Linyphia triangularis, Araneae: Linyphiidae)

USGS Publications Warehouse

Bednarski, Julie V.; Ginsberg, Howard S.; Jakob, Elizabeth M.

2010-01-01

There are numerous reports of spiders that have become established outside of their native ranges, but few studies examine their impact on native spiders. We examined the effect of the European hammock spider Linyphia triangularis (Araneae, Linyphiidae) on the native bowl-and-doily spider Frontinella communis (Araneae, Linyphiidae) in Acadia National Park, Maine, USA. First, we added L. triangularis to established plots of F. communis. Significantly more F. communis abandoned their webs when L. triangularis were added compared to control plots. Second, we tested whether F. communis were deterred from building webs in areas where L. triangularis was established. Significantly fewer F. communis built webs on plots with L. triangularis than on control plots. In both experiments, L. triangularis sometimes took over webs of F. communis or incorporated F. communis webs into their own webs, but F. communisnever took over or incorporated L. triangularis webs. Competition between L. triangularis and F. communis for both webs and web sites may contribute to the decline of F. communis.

A pintail duck swims in the water at KSC

NASA Technical Reports Server (NTRS)

1999-01-01

A pintail duck swims calmly in the waters of the Merritt Island National Wildlife Refuge, which shares a boundary with the space center. The pintail can be found in marshes, prairie ponds and tundra, and salt marshes in winter. They range from Alaska and Greenland south to Central America and the West Indies. The open waters of the Wildlife Refuge provide wintering areas for 23 species of migratory waterfowl as well as a year-round home for great blue herons, great egrets, wood storks, cormorants, brown pelicans and other species of marsh and shore birds. The refuge comprises 92,000 acres, ranging from fresh-water impoundments, salt-water estuaries and brackish marshes to hardwood hammocks and pine flatwoods. The diverse landscape provides habitat for more than 310 species of birds, 25 mammals, 117 fishes, and 65 amphibians and reptiles, including such endangered species as Southern bald eagles, wood storks, Florida scrub jays, Atlantic loggerhead and leatherback turtles, osprey, and nearly 5,000 alligators.

KSC-2012-4868

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Aquatic biologist Eric Reyier with Innovative Health Applications, or IHA, talks about the work that goes into protecting the natural habitat at a launch operations center during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. In the background is Kennedy's Launch Complex 39. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4847

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Cape Canaveral Air Force Station's Solid Motor Assembly and Readiness Facility, or SMARF, Space Launch Complex 40, Space Exploration Technologies, or SpaceX, facility, and Solid Motor Assembly Building, or SMAB, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4874

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Cape Canaveral Air Force Station's Solid Motor Assembly and Readiness Facility, or SMARF, Space Launch Complex 40, and Space Exploration Technologies, or SpaceX, facility, is seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

Database extraction strategies for low-template evidence.

PubMed

Bleka, Øyvind; Dørum, Guro; Haned, Hinda; Gill, Peter

2014-03-01

Often in forensic cases, the profile of at least one of the contributors to a DNA evidence sample is unknown and a database search is needed to discover possible perpetrators. In this article we consider two types of search strategies to extract suspects from a database using methods based on probability arguments. The performance of the proposed match scores is demonstrated by carrying out a study of each match score relative to the level of allele drop-out in the crime sample, simulating low-template DNA. The efficiency was measured by random man simulation and we compared the performance using the SGM Plus kit and the ESX 17 kit for the Norwegian population, demonstrating that the latter has greatly enhanced power to discover perpetrators of crime in large national DNA databases. The code for the database extraction strategies will be prepared for release in the R-package forensim. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Steady and transient regimes in hydropower plants

NASA Astrophysics Data System (ADS)

Gajic, A.

2013-12-01

Hydropower plant that has been in operation for about 30 years has to be reconstructed. They have already installed 12 Kaplan turbines, the largest in the world at that time. The existing CAM relationship was determined based on hydraulic model tests and checked by efficiency on-site tests. It was also tested based on turbine bearing vibrations. In order to discover vibrations and long cracks on stay vanes detailed on-site measurements were performed. Influence of the modification of the trailing edges on the dynamic stresses of the stay vanes is also shown. In order to improve power output transient regimes were analyzed, both experimentally and numerically. Reversible hydropower plant, a pioneer in Europe since it was the first Pump storage power plant constructed with the highest head pump-turbines in the world. Analyses of transient regimes discover some problems with S-shaped characteristics coupled with non-symmetrical penstock.

Evaluating WRF Simulations of Urban Boundary Layer Processes during DISCOVER-AQ

NASA Astrophysics Data System (ADS)

Hegarty, J. D.; Henderson, J.; Lewis, J. R.; McGrath-Spangler, E. L.; Scarino, A. J.; Ferrare, R. A.; DeCola, P.; Welton, E. J.

2015-12-01

The accurate representation of processes in the planetary boundary layer (PBL) in meteorological models is of prime importance to air quality and greenhouse gas simulations as it governs the depth to which surface emissions are vertically mixed and influences the efficiency by which they are transported downwind. In this work we evaluate high resolution (~1 km) WRF simulations of PBL processes in the Washington DC - Baltimore and Houston urban areas during the respective DISCOVER-AQ 2011 and 2013 field campaigns using MPLNET micro-pulse lidar (MPL), mini-MPL, airborne high spectral resolution lidar (HSRL), Doppler wind profiler and CALIPSO satellite measurements along with complimentary surface and aircraft measurements. We will discuss how well WRF simulates the spatiotemporal variability of the PBL height in the urban areas and the development of fine-scale meteorological features such as bay and sea breezes that influence the air quality of the urban areas studied.

Mining and Utilizing Dataset Relevancy from Oceanographic Dataset (MUDROD) Metadata, Usage Metrics, and User Feedback to Improve Data Discovery and Access

NASA Astrophysics Data System (ADS)

Jiang, Y.

2015-12-01

Oceanographic resource discovery is a critical step for developing ocean science applications. With the increasing number of resources available online, many Spatial Data Infrastructure (SDI) components (e.g. catalogues and portals) have been developed to help manage and discover oceanographic resources. However, efficient and accurate resource discovery is still a big challenge because of the lack of data relevancy information. In this article, we propose a search engine framework for mining and utilizing dataset relevancy from oceanographic dataset metadata, usage metrics, and user feedback. The objective is to improve discovery accuracy of oceanographic data and reduce time for scientist to discover, download and reformat data for their projects. Experiments and a search example show that the propose engine helps both scientists and general users search for more accurate results with enhanced performance and user experience through a user-friendly interface.

Gravitational Waves From Ultra Short Period Exoplanets

NASA Astrophysics Data System (ADS)

Cunha, J. V.; Silva, F. E.; Lima, J. A. S.

2018-06-01

In the last two decades, thousands of extrasolar planets were discovered based on different observational techniques, and their number must increase substantially in virtue of the ongoing and near-future approved missions and facilities. It is shown that interesting signatures of binary systems from nearby exoplanets and their parent stars can also be obtained measuring the pattern of gravitational waves that will be made available by the new generation of detectors including the space-based LISA (Laser Interferometer Space Antenna) observatory. As an example, a subset of exoplanets with extremely short periods (less than 80 min) is discussed. All of them have gravitational luminosity, LGW ˜ 1030erg/s, strain h ˜ 10-22, frequencies fgw > 10-4Hz, and, as such, are within the standard sensitivity curve of LISA. Our analysis suggests that the emitted gravitational wave pattern may also provide an efficient tool to discover ultra short period exoplanets.

Discovery of pyridine-based agrochemicals by using Intermediate Derivatization Methods.

PubMed

Guan, Ai-Ying; Liu, Chang-Ling; Sun, Xu-Feng; Xie, Yong; Wang, Ming-An

2016-02-01

Pyridine-based compounds have been playing a crucial role as agrochemicals or pesticides including fungicides, insecticides/acaricides and herbicides, etc. Since most of the agrochemicals listed in the Pesticide Manual were discovered through screening programs that relied on trial-and-error testing and new agrochemical discovery is not benefiting as much from the in silico new chemical compound identification/discovery techniques used in pharmaceutical research, it has become more important to find new methods to enhance the efficiency of discovering novel lead compounds in the agrochemical field to shorten the time of research phases in order to meet changing market requirements. In this review, we selected 18 representative known agrochemicals containing a pyridine moiety and extrapolate their discovery from the perspective of Intermediate Derivatization Methods in the hope that this approach will have greater appeal to researchers engaged in the discovery of agrochemicals and/or pharmaceuticals. Copyright © 2015 Elsevier Ltd. All rights reserved.

Prediction of Low-Thermal-Conductivity Compounds with First-Principles Anharmonic Lattice-Dynamics Calculations and Bayesian Optimization

NASA Astrophysics Data System (ADS)

Seko, Atsuto; Togo, Atsushi; Hayashi, Hiroyuki; Tsuda, Koji; Chaput, Laurent; Tanaka, Isao

2015-11-01

Compounds of low lattice thermal conductivity (LTC) are essential for seeking thermoelectric materials with high conversion efficiency. Some strategies have been used to decrease LTC. However, such trials have yielded successes only within a limited exploration space. Here, we report the virtual screening of a library containing 54 779 compounds. Our strategy is to search the library through Bayesian optimization using for the initial data the LTC obtained from first-principles anharmonic lattice-dynamics calculations for a set of 101 compounds. We discovered 221 materials with very low LTC. Two of them even have an electronic band gap <1 eV , which makes them exceptional candidates for thermoelectric applications. In addition to those newly discovered thermoelectric materials, the present strategy is believed to be powerful for many other applications in which the chemistry of materials is required to be optimized.

A Prerecognition Model for Hot Topic Discovery Based on Microblogging Data

PubMed Central

Zhu, Tongyu

2014-01-01

The microblogging is prevailing since its easy and anonymous information sharing at Internet, which also brings the issue of dispersing negative topics, or even rumors. Many researchers have focused on how to find and trace emerging topics for analysis. When adopting topic detection and tracking techniques to find hot topics with streamed microblogging data, it will meet obstacles like streamed microblogging data clustering, topic hotness definition, and emerging hot topic discovery. This paper schemes a novel prerecognition model for hot topic discovery. In this model, the concepts of the topic life cycle, the hot velocity, and the hot acceleration are promoted to calculate the change of topic hotness, which aims to discover those emerging hot topics before they boost and break out. Our experiments show that this new model would help to discover potential hot topics efficiently and achieve considerable performance. PMID:25254235

A prerecognition model for hot topic discovery based on microblogging data.

PubMed

Zhu, Tongyu; Yu, Jianjun

2014-01-01

The microblogging is prevailing since its easy and anonymous information sharing at Internet, which also brings the issue of dispersing negative topics, or even rumors. Many researchers have focused on how to find and trace emerging topics for analysis. When adopting topic detection and tracking techniques to find hot topics with streamed microblogging data, it will meet obstacles like streamed microblogging data clustering, topic hotness definition, and emerging hot topic discovery. This paper schemes a novel prerecognition model for hot topic discovery. In this model, the concepts of the topic life cycle, the hot velocity, and the hot acceleration are promoted to calculate the change of topic hotness, which aims to discover those emerging hot topics before they boost and break out. Our experiments show that this new model would help to discover potential hot topics efficiently and achieve considerable performance.

Draft genome sequence of a Kluyvera intermedia isolate from a patient with a pancreatic abscess.

PubMed

Thele, Roland; Gumpert, Heidi; Christensen, Louise B; Worning, Peder; Schønning, Kristian; Westh, Henrik; Hansen, Thomas A

2017-09-01

The genus Kluyvera comprises potential pathogens that can cause many infections. This study reports a Kluyvera intermedia strain (FOSA7093) from a pancreatic cyst specimen from a long-term hospitalised patient. Whole-genome sequencing (WGS) of the K. intermedia isolate was performed and the strain was reported as sensitive to Danish-registered antibiotics although it had a fosA-like gene in the genome. There were nine contigs that aligned to a plasmid, and these contigs contained several heavy metal resistance gene homologues. Furthermore, a prophage was discovered in the genome. WGS represents an efficient tool for monitoring Kluyvera spp. and its role as a reservoir of multidrug resistance. Therefore, this susceptible K. intermedia genome has many characteristics that allow comparison of resistant K. intermedia that might be discovered in the future. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

On the use of big-bang method to generate low-energy structures of atomic clusters modeled with pair potentials of different ranges.

PubMed

Marques, J M C; Pais, A A C C; Abreu, P E

2012-02-05

The efficiency of the so-called big-bang method for the optimization of atomic clusters is analysed in detail for Morse pair potentials with different ranges; here, we have used Morse potentials with four different ranges, from long- ρ = 3) to short-ranged ρ = 14) interactions. Specifically, we study the efficacy of the method in discovering low-energy structures, including the putative global minimum, as a function of the potential range and the cluster size. A new global minimum structure for long-ranged ρ = 3) Morse potential at the cluster size of n= 240 is reported. The present results are useful to assess the maximum cluster size for each type of interaction where the global minimum can be discovered with a limited number of big-bang trials. Copyright © 2011 Wiley Periodicals, Inc.

The design and implementation of web mining in web sites security

NASA Astrophysics Data System (ADS)

Li, Jian; Zhang, Guo-Yin; Gu, Guo-Chang; Li, Jian-Li

2003-06-01

The backdoor or information leak of Web servers can be detected by using Web Mining techniques on some abnormal Web log and Web application log data. The security of Web servers can be enhanced and the damage of illegal access can be avoided. Firstly, the system for discovering the patterns of information leakages in CGI scripts from Web log data was proposed. Secondly, those patterns for system administrators to modify their codes and enhance their Web site security were provided. The following aspects were described: one is to combine web application log with web log to extract more information, so web data mining could be used to mine web log for discovering the information that firewall and Information Detection System cannot find. Another approach is to propose an operation module of web site to enhance Web site security. In cluster server session, Density-Based Clustering technique is used to reduce resource cost and obtain better efficiency.

A Hybrid Genetic Programming Algorithm for Automated Design of Dispatching Rules.

PubMed

Nguyen, Su; Mei, Yi; Xue, Bing; Zhang, Mengjie

2018-06-04

Designing effective dispatching rules for production systems is a difficult and timeconsuming task if it is done manually. In the last decade, the growth of computing power, advanced machine learning, and optimisation techniques has made the automated design of dispatching rules possible and automatically discovered rules are competitive or outperform existing rules developed by researchers. Genetic programming is one of the most popular approaches to discovering dispatching rules in the literature, especially for complex production systems. However, the large heuristic search space may restrict genetic programming from finding near optimal dispatching rules. This paper develops a new hybrid genetic programming algorithm for dynamic job shop scheduling based on a new representation, a new local search heuristic, and efficient fitness evaluators. Experiments show that the new method is effective regarding the quality of evolved rules. Moreover, evolved rules are also significantly smaller and contain more relevant attributes.

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.

PubMed

Frett, Brendan; McConnell, Nick; Smith, Catherine C; Wang, Yuanxiang; Shah, Neil P; Li, Hong-yu

2015-04-13

The FLT3 kinase represents an attractive target to effectively treat AML. Unfortunately, no FLT3 targeted therapeutic is currently approved. In line with our continued interests in treating kinase related disease for anti-FLT3 mutant activity, we utilized pioneering synthetic methodology in combination with computer aided drug discovery and identified low molecular weight, highly ligand efficient, FLT3 kinase inhibitors. Compounds were analyzed for biochemical inhibition, their ability to selectively inhibit cell proliferation, for FLT3 mutant activity, and preliminary aqueous solubility. Validated hits were discovered that can serve as starting platforms for lead candidates. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

An Approach to Self-Assembling Swarm Robots Using Multitree Genetic Programming

PubMed Central

An, Jinung

2013-01-01

In recent days, self-assembling swarm robots have been studied by a number of researchers due to their advantages such as high efficiency, stability, and scalability. However, there are still critical issues in applying them to practical problems in the real world. The main objective of this study is to develop a novel self-assembling swarm robot algorithm that overcomes the limitations of existing approaches. To this end, multitree genetic programming is newly designed to efficiently discover a set of patterns necessary to carry out the mission of the self-assembling swarm robots. The obtained patterns are then incorporated into their corresponding robot modules. The computational experiments prove the effectiveness of the proposed approach. PMID:23861655

[Extragenital endometriosis: Parietal, thoracic, diaphragmatic and nervous lesions. CNGOF-HAS Endometriosis Guidelines].

PubMed

Merlot, B; Ploteau, S; Abergel, A; Rubob, C; Hocke, C; Canis, M; Fritel, X; Roman, H; Collinet, P

2018-03-01

According to some studies, extragenital endometriosis represents 5% of the localisations. Its prevalence seems to be underestimated. The extra pelvic localisation can make the diagnosis more difficult. Nevertheless, the recurrent and catamenial symptomatology can evoke this pathology. Surgery seems to be the unique efficient treatment for parietal lesions. Pain linked to nervous lesions (peripheric and sacral roots) seems to be underestimated and difficult to diagnose because of various localisations. Neurolysis seems to have encouraging results. Diaphragmatic lesions are often discovered either incidentally during laparoscopy, or by pulmonary symptomatology as recurrent catamenial pneumothorax or cyclic thoracic pain. Surgical treatment seems as well to be efficient. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

An approach to self-assembling swarm robots using multitree genetic programming.

PubMed

Lee, Jong-Hyun; Ahn, Chang Wook; An, Jinung

2013-01-01

In recent days, self-assembling swarm robots have been studied by a number of researchers due to their advantages such as high efficiency, stability, and scalability. However, there are still critical issues in applying them to practical problems in the real world. The main objective of this study is to develop a novel self-assembling swarm robot algorithm that overcomes the limitations of existing approaches. To this end, multitree genetic programming is newly designed to efficiently discover a set of patterns necessary to carry out the mission of the self-assembling swarm robots. The obtained patterns are then incorporated into their corresponding robot modules. The computational experiments prove the effectiveness of the proposed approach.

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

PubMed

Angeli, A; Peat, T S; Bartolucci, G; Nocentini, A; Supuran, C T; Carta, F

2016-12-28

A mild, efficient and one pot procedure to access benzoxazoles using easily accessible acylselenoureas as starting materials has been discovered. Mechanistic studies revealed a pH dependent intramolecular oxidative deselenization, with ring closure due to an intramolecular nucleophilic attack of a phenoxide ion. All the benzoxazoles herein reported possessed a primary sulfonamide zinc binding group and showed effective inhibitory action on the enzymes, carbonic anhydrases.

Formation of TRAPPIST-1

NASA Astrophysics Data System (ADS)

Ormel, C. W.; Liu, B.; Schoonenberg, D.

2017-09-01

We present a model for the formation of the recently-discovered TRAPPIST-1 planetary system. In our scenario planets form in the interior regions, by accretion of mm to cm-size particles (pebbles) that drifted from the outer disk. This scenario has several advantages: it connects to the observation that disks are made up of pebbles, it is efficient, it explains why the TRAPPIST-1 planets are ˜Earth mass, and it provides a rationale for the system's architecture.

Evaluation of Fuel Cell Operation and Degradation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Mark; Gemmen, Randall; Richards, George

The concepts of area specific resistance (ASR) and degradation are developed for different fuel cell operating modes. The concepts of exergetic efficiency and entropy production were applied to ASR and degradation. It is shown that exergetic efficiency is a time-dependent function useful describing the thermal efficiency of a fuel cell and the change in thermal efficiency of a degrading fuel cell. Entropy production was evaluated for the cases of constant voltage operation and constant current operation of the fuel cell for a fuel cell undergoing ohmic degradation. It was discovered that the Gaussian hypergeometric function describes the cumulative entropy andmore » electrical work produced by fuel cells operating at constant voltage. The Gaussian hypergeometric function is found in many applications in modern physics. This paper builds from and is an extension of several papers recently published by the authors in the Journal of The Electrochemical Society (ECS), ECS Transactions, Journal of Power Sources, and the Journal of Fuel Cell Science and Technology.« less

Selection Metric for Photovoltaic Materials Screening Based on Detailed-Balance Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blank, Beatrix; Kirchartz, Thomas; Lany, Stephan

The success of recently discovered absorber materials for photovoltaic applications has been generating increasing interest in systematic materials screening over the last years. However, the key for a successful materials screening is a suitable selection metric that goes beyond the Shockley-Queisser theory that determines the thermodynamic efficiency limit of an absorber material solely by its band-gap energy. Here, we develop a selection metric to quantify the potential photovoltaic efficiency of a material. Our approach is compatible with detailed balance and applicable in computational and experimental materials screening. We use the complex refractive index to calculate radiative and nonradiative efficiency limitsmore » and the respective optimal thickness in the high mobility limit. We also compare our model to the widely applied selection metric by Yu and Zunger [Phys. Rev. Lett. 108, 068701 (2012)] with respect to their dependence on thickness, internal luminescence quantum efficiency, and refractive index. Finally, the model is applied to complex refractive indices calculated via electronic structure theory.« less

Selection Metric for Photovoltaic Materials Screening Based on Detailed-Balance Analysis

DOE PAGES

Blank, Beatrix; Kirchartz, Thomas; Lany, Stephan; ...

2017-08-31

The success of recently discovered absorber materials for photovoltaic applications has been generating increasing interest in systematic materials screening over the last years. However, the key for a successful materials screening is a suitable selection metric that goes beyond the Shockley-Queisser theory that determines the thermodynamic efficiency limit of an absorber material solely by its band-gap energy. Here, we develop a selection metric to quantify the potential photovoltaic efficiency of a material. Our approach is compatible with detailed balance and applicable in computational and experimental materials screening. We use the complex refractive index to calculate radiative and nonradiative efficiency limitsmore » and the respective optimal thickness in the high mobility limit. We also compare our model to the widely applied selection metric by Yu and Zunger [Phys. Rev. Lett. 108, 068701 (2012)] with respect to their dependence on thickness, internal luminescence quantum efficiency, and refractive index. Finally, the model is applied to complex refractive indices calculated via electronic structure theory.« less

Hydrologic measurements and implications for tree island formation within Everglades National Park

NASA Astrophysics Data System (ADS)

Bazante, Jose; Jacobi, Gary; Solo-Gabriele, Helena M.; Reed, David; Mitchell-Bruker, Sherry; Childers, Daniel L.; Leonard, Lynn; Ross, Michael

2006-10-01

SummaryTree islands in the Shark River Slough of the Everglades National Park (ENP), in the southern state of Florida in the United States, are part of a wetland system of densely vegetated ridges interspersed within relatively open sloughs. Human alteration of this system has had dramatic negative effects on the landscape of the region and restoration efforts will require adjusting the hydrology of the region to assure the preservation of these important ecologic features. The primary objectives of this study were to document the hydrology in the vicinity of tree islands in ENP by measuring velocities in time and space and by characterizing suspended sediments. The results of such measurements were interpreted with respect to factors that may limit tree island growth. The measurements were conducted in the vicinity of three tree islands known as Black Hammock (BH), Gumbo Limbo (GL), and an unnamed island that was named for this study as Satin Leaf (SL). Acoustical Doppler Velocity (ADV) meters were used for measuring the low velocities of the Everglades water flow. Properties of suspended sediments were characterized through measurements of particle size distribution, turbidity, concentration and particle density. Mean velocities observed at each of the tree islands varied from 0.9 to 1.4 cm/s. Slightly higher mean velocities were observed during the wet season (1.2-1.6 cm/s) versus the dry season (0.8-1.3 cm/s). Maximum velocities of more than 4 cm/s were measured in areas of Cladium jamaicense die-off and at the hardwood hammock (head) of the islands. At the island's head, water is channelized around obstructions such as tree trunks in relatively rapid flow, which may limit the lateral extent of tree island growth. Channelization is facilitated by shade from the tree canopy, which limits the growth of underwater vegetation thereby minimizing the resistance to flow and limiting sediment deposition. Suspended sediment concentrations were low (0.5-1.5 mg/L) at all study sites and were primarily of organic origin. The mean particle size of the suspended sediments was 3 μm with a distribution that was exponential. Critical velocities needed to cause re-suspension of these particles were estimated to be above the actual velocities observed. Sediment transport within the water column appears to be at a near steady state during the conditions evaluated with low rates of sediment loss balanced by presumably the release of equivalent quantities of particles of organic origin. Existing hydrologic conditions do not appear to transport sufficient suspended sediments to result in the formation of tree islands. Of interest would be to collect hydrologic and sediment transport data during extreme hydrologic events to determine if enough sediment is transported under these conditions to promote sufficient sediment accumulations.

Clinical research and the development of medical therapeutics.

PubMed

Antman, Elliott M

2014-01-01

Clinical research plays a central role in the development of medical therapeutics, but the current system is estimated to take 10-15 years from initial discovery to regulatory approval, at a cost of approximately US$1 billion. Contrast the paths by which 2 anticoagulant options for atrial fibrillation were discovered and ultimately established as treatment options in clinical medicine. Warfarin was discovered by serendipity and compared with placebo in relatively small trials; this was associated with a low cost of development. The new oral anticoagulants were synthesized to provide highly specific, targeted inhibition of critical steps in the coagulation system. They were compared with warfarin for prevention of stroke and systemic embolic events in large, phase 3 trials; this resulted in very expensive development programs. Neither of these paths is desirable for future development of therapeutics. We need to focus on innovative approaches at the preclinical level (systems approach, greater use of inducible pluripotent stem cells, use of novel bioengineering platforms) and clinical trial level (adaptive design, greater use of new and emerging technology). Focusing on disruptive innovations for development of medical therapeutics has the potential to bring us closer to the goal of precision medicine where safer, more effective treatments are discovered in a more efficient system.

Ffuzz: Towards full system high coverage fuzz testing on binary executables.

PubMed

Zhang, Bin; Ye, Jiaxi; Bi, Xing; Feng, Chao; Tang, Chaojing

2018-01-01

Bugs and vulnerabilities in binary executables threaten cyber security. Current discovery methods, like fuzz testing, symbolic execution and manual analysis, both have advantages and disadvantages when exercising the deeper code area in binary executables to find more bugs. In this paper, we designed and implemented a hybrid automatic bug finding tool-Ffuzz-on top of fuzz testing and selective symbolic execution. It targets full system software stack testing including both the user space and kernel space. Combining these two mainstream techniques enables us to achieve higher coverage and avoid getting stuck both in fuzz testing and symbolic execution. We also proposed two key optimizations to improve the efficiency of full system testing. We evaluated the efficiency and effectiveness of our method on real-world binary software and 844 memory corruption vulnerable programs in the Juliet test suite. The results show that Ffuzz can discover software bugs in the full system software stack effectively and efficiently.

Tracking down quirks at the Large Hadron Collider

NASA Astrophysics Data System (ADS)

Knapen, Simon; Lou, Hou Keong; Papucci, Michele; Setford, Jack

2017-12-01

Nonhelical tracks are the smoking gun signature of charged and/or colored quirks, which are pairs of particles bound by a new, long-range confining force. We propose a method to efficiently search for these nonhelical tracks at the LHC, without the need to fit their trajectories. We show that the hits corresponding to quirky trajectories can be selected efficiently by searching for coplanar hits in the inner layers of the ATLAS and CMS trackers, even in the presence of on average 50 pile-up vertices. We further argue that backgrounds from photon conversions and unassociated pile-up hits can be removed almost entirely, while maintaining a signal reconstruction efficiency as high as ˜70 % . With the 300 fb-1 dataset, this implies a discovery potential for string tension between 100 eV and 30 keV, and colored (electroweak charged) quirks as heavy as 1600 (650) GeV may be discovered.

Ambulatory surgery centers best practices for the 90s.

PubMed

Hoover, J A

1994-05-01

Outpatient surgery will be the driving force in the continued growth of ambulatory care in the 1990s. Providing efficient, high-quality ambulatory surgical services should therefore be a priority among healthcare providers. Arthur Andersen conducted a survey to discover best practices in ambulatory surgical service. General success characteristics of best performers were business-focused relationships with physicians, the use of clinical protocols, patient convenience, cost management, strong leadership, teamwork, streamlined processes and efficient design. Other important factors included scheduling to maximize OR room use; achieving surgical efficiencies through reduced case pack assembly errors and equipment availability; a focus on cost capture rather than charge capture; sound materiel management practices, such as standardization and vendor teaming; and the appropriate use of automated systems. It is important to evaluate whether the best practices are applicable to your environment and what specific changes to your current processes would be necessary to adopt them.

Evaluation and application of summary statistic imputation to discover new height-associated loci.

PubMed

Rüeger, Sina; McDaid, Aaron; Kutalik, Zoltán

2018-05-01

As most of the heritability of complex traits is attributed to common and low frequency genetic variants, imputing them by combining genotyping chips and large sequenced reference panels is the most cost-effective approach to discover the genetic basis of these traits. Association summary statistics from genome-wide meta-analyses are available for hundreds of traits. Updating these to ever-increasing reference panels is very cumbersome as it requires reimputation of the genetic data, rerunning the association scan, and meta-analysing the results. A much more efficient method is to directly impute the summary statistics, termed as summary statistics imputation, which we improved to accommodate variable sample size across SNVs. Its performance relative to genotype imputation and practical utility has not yet been fully investigated. To this end, we compared the two approaches on real (genotyped and imputed) data from 120K samples from the UK Biobank and show that, genotype imputation boasts a 3- to 5-fold lower root-mean-square error, and better distinguishes true associations from null ones: We observed the largest differences in power for variants with low minor allele frequency and low imputation quality. For fixed false positive rates of 0.001, 0.01, 0.05, using summary statistics imputation yielded a decrease in statistical power by 9, 43 and 35%, respectively. To test its capacity to discover novel associations, we applied summary statistics imputation to the GIANT height meta-analysis summary statistics covering HapMap variants, and identified 34 novel loci, 19 of which replicated using data in the UK Biobank. Additionally, we successfully replicated 55 out of the 111 variants published in an exome chip study. Our study demonstrates that summary statistics imputation is a very efficient and cost-effective way to identify and fine-map trait-associated loci. Moreover, the ability to impute summary statistics is important for follow-up analyses, such as Mendelian randomisation or LD-score regression.

Evaluation and application of summary statistic imputation to discover new height-associated loci

PubMed Central

2018-01-01

As most of the heritability of complex traits is attributed to common and low frequency genetic variants, imputing them by combining genotyping chips and large sequenced reference panels is the most cost-effective approach to discover the genetic basis of these traits. Association summary statistics from genome-wide meta-analyses are available for hundreds of traits. Updating these to ever-increasing reference panels is very cumbersome as it requires reimputation of the genetic data, rerunning the association scan, and meta-analysing the results. A much more efficient method is to directly impute the summary statistics, termed as summary statistics imputation, which we improved to accommodate variable sample size across SNVs. Its performance relative to genotype imputation and practical utility has not yet been fully investigated. To this end, we compared the two approaches on real (genotyped and imputed) data from 120K samples from the UK Biobank and show that, genotype imputation boasts a 3- to 5-fold lower root-mean-square error, and better distinguishes true associations from null ones: We observed the largest differences in power for variants with low minor allele frequency and low imputation quality. For fixed false positive rates of 0.001, 0.01, 0.05, using summary statistics imputation yielded a decrease in statistical power by 9, 43 and 35%, respectively. To test its capacity to discover novel associations, we applied summary statistics imputation to the GIANT height meta-analysis summary statistics covering HapMap variants, and identified 34 novel loci, 19 of which replicated using data in the UK Biobank. Additionally, we successfully replicated 55 out of the 111 variants published in an exome chip study. Our study demonstrates that summary statistics imputation is a very efficient and cost-effective way to identify and fine-map trait-associated loci. Moreover, the ability to impute summary statistics is important for follow-up analyses, such as Mendelian randomisation or LD-score regression. PMID:29782485

Job satisfaction or production? How staff and leadership understand operating room efficiency: a qualitative study.

PubMed

Arakelian, E; Gunningberg, L; Larsson, J

2008-11-01

How to increase efficiency in operating departments has been widely studied. However, there is no overall definition of efficiency. Supervisors urging staff to work efficiently may meet strong reactions due to staff believing that demands for efficiency means just stress at work. Differences in how efficiency is understood may constitute an obstacle to supervisors' efforts to promote it. This study aimed to explore how staff and leadership understand operating room efficiency. Twenty-one members of staff and supervisors in an operating department in a Swedish county hospital were interviewed. The analysis was performed with a phenomenographic approach that aims to discover the variations in how a phenomenon is understood by a group of people. Six categories were found in the understanding of operation room efficiency: (A) having the right qualifications; (B) enjoying work; (C) planning and having good control and overview; (D) each professional performing the correct tasks; (E) completing a work assignment; and (F) producing as much as possible per time unit. The most significant finding was that most of the nurses and assistant nurses understood efficiency as individual knowledge and experience emphasizing the importance of the work process, whereas the supervisors and physicians understood efficiency in terms of production per time unit or completing an assignment. The concept 'operating room efficiency' is understood in different ways by leadership and staff members. Supervisors who are aware of this variation will have better prerequisites for defining the concept and for creating a common platform towards becoming efficient.

A proteomics strategy to discover beta-glucosidases from Aspergillus fumigatus with two-dimensional page in-gel activity assay and tandem mass spectrometry.

PubMed

Kim, Kee-Hong; Brown, Kimberly M; Harris, Paul V; Langston, James A; Cherry, Joel R

2007-12-01

Economically competitive production of ethanol from lignocellulosic biomass by enzymatic hydrolysis and fermentation is currently limited, in part, by the relatively high cost and low efficiency of the enzymes required to hydrolyze cellulose to fermentable sugars. Discovery of novel cellulases with greater activity could be a critical step in overcoming this cost barrier. beta-Glucosidase catalyzes the final step in conversion of glucose polymers to glucose. Despite the importance, only a few beta-glucosidases are commercially available, and more efficient ones are clearly needed. We developed a proteomics strategy aiming to discover beta-glucosidases present in the secreted proteome of the cellulose-degrading fungus Aspergillus fumigatus. With the use of partial or complete protein denaturing conditions, the secretory proteome was fractionated in a 2DGE format and beta-glucosidase activity was detected in the gel after infusion with a substrate analogue that fluoresces upon hydrolysis. Fluorescing spots were subjected to tryptic-digestion, and identification as beta-glucosidases was confirmed by tandem mass spectrometry. Two novel beta-glucosidases of A. fumigatus were identified by this in situ activity staining method, and the gene coding for a novel beta-glucosidase ( EAL88289 ) was cloned and heterologously expressed. The expressed beta-glucosidase showed far superior heat stability to the previously characterized beta-glucosidases of Aspergillus niger and Aspergillus oryzae. Improved heat stability is important for development of the next generation of saccharifying enzymes capable of performing fast cellulose hydrolysis reactions at elevated temperatures, thereby lowering the cost of bioethanol production. The in situ activity staining approach described here would be a useful tool for cataloguing and assessing the efficiency of beta-glucosidases in a high throughput fashion.

Efficient Geometric Probabilities of Multi-transiting Systems, Circumbinary Planets, and Exoplanet Mutual Events

NASA Astrophysics Data System (ADS)

Brakensiek, Joshua; Ragozzine, D.

2012-10-01

The transit method for discovering extra-solar planets relies on detecting regular diminutions of light from stars due to the shadows of planets passing in between the star and the observer. NASA's Kepler Mission has successfully discovered thousands of exoplanet candidates using this technique, including hundreds of stars with multiple transiting planets. In order to estimate the frequency of these valuable systems, our research concerns the efficient calculation of geometric probabilities for detecting multiple transiting extrasolar planets around the same parent star. In order to improve on previous studies that used numerical methods (e.g., Ragozzine & Holman 2010, Tremaine & Dong 2011), we have constructed an efficient, analytical algorithm which, given a collection of conjectured exoplanets orbiting a star, computes the probability that any particular group of exoplanets are transiting. The algorithm applies theorems of elementary differential geometry to compute the areas bounded by circular curves on the surface of a sphere (see Ragozzine & Holman 2010). The implemented algorithm is more accurate and orders of magnitude faster than previous algorithms, based on comparison with Monte Carlo simulations. Expanding this work, we have also developed semi-analytical methods for determining the frequency of exoplanet mutual events, i.e., the geometric probability two planets will transit each other (Planet-Planet Occultation) and the probability that this transit occurs simultaneously as they transit their star (Overlapping Double Transits; see Ragozzine & Holman 2010). The latter algorithm can also be applied to calculating the probability of observing transiting circumbinary planets (Doyle et al. 2011, Welsh et al. 2012). All of these algorithms have been coded in C and will be made publicly available. We will present and advertise these codes and illustrate their value for studying exoplanetary systems.

Main-belt comets in the Palomar Transient Factory survey - I. The search for extendedness

NASA Astrophysics Data System (ADS)

Waszczak, A.; Ofek, E. O.; Aharonson, O.; Kulkarni, S. R.; Polishook, D.; Bauer, J. M.; Levitan, D.; Sesar, B.; Laher, R.; Surace, J.; PTF Team

2013-08-01

Cometary activity in main-belt asteroids probes the ice content of these objects and provides clues to the history of volatiles in the inner Solar system. We search the Palomar Transient Factory survey to derive upper limits on the population size of active main-belt comets (MBCs). From data collected from 2009 March through 2012 July, we extracted ˜2 million observations of ˜220 thousand known main-belt objects (40 per cent of the known population, down to ˜1-km diameter) and discovered 626 new objects in multinight linked detections. We formally quantify the `extendedness' of a small-body observation, account for systematic variation in this metric (e.g. due to on-sky motion) and evaluate this method's robustness in identifying cometary activity using observations of 115 comets, including two known candidate MBCs and six newly discovered non-MBCs (two of which were originally designated as asteroids by other surveys). We demonstrate a 66 per cent detection efficiency with respect to the extendedness distribution of the 115 sampled comets, and a 100 per cent detection efficiency with respect to extendedness levels greater than or equal to those we observed in the known candidate MBCs P/2010 R2 (La Sagra) and P/2006 VW139. Using a log-constant prior, we infer 95 per cent confidence upper limits of 33 and 22 active MBCs (per million main-belt asteroids down to ˜1-km diameter), for detection efficiencies of 66 and 100 per cent, respectively. In a follow-up to this morphological search, we will perform a photometric (disc-integrated brightening) search for MBCs.

Dynamic social community detection and its applications.

PubMed

Nguyen, Nam P; Dinh, Thang N; Shen, Yilin; Thai, My T

2014-01-01

Community structure is one of the most commonly observed features of Online Social Networks (OSNs) in reality. The knowledge of this feature is of great advantage: it not only provides helpful insights into developing more efficient social-aware solutions but also promises a wide range of applications enabled by social and mobile networking, such as routing strategies in Mobile Ad Hoc Networks (MANETs) and worm containment in OSNs. Unfortunately, understanding this structure is very challenging, especially in dynamic social networks where social interactions are evolving rapidly. Our work focuses on the following questions: How can we efficiently identify communities in dynamic social networks? How can we adaptively update the network community structure based on its history instead of recomputing from scratch? To this end, we present Quick Community Adaptation (QCA), an adaptive modularity-based framework for not only discovering but also tracing the evolution of network communities in dynamic OSNs. QCA is very fast and efficient in the sense that it adaptively updates and discovers the new community structure based on its history together with the network changes only. This flexible approach makes QCA an ideal framework applicable for analyzing large-scale dynamic social networks due to its lightweight computing-resource requirement. To illustrate the effectiveness of our framework, we extensively test QCA on both synthesized and real-world social networks including Enron, arXiv e-print citation, and Facebook networks. Finally, we demonstrate the applicability of QCA in real applications: (1) A social-aware message forwarding strategy in MANETs, and (2) worm propagation containment in OSNs. Competitive results in comparison with other methods reveal that social-based techniques employing QCA as a community detection core outperform current available methods.

Dynamic Social Community Detection and Its Applications

PubMed Central

Nguyen, Nam P.; Dinh, Thang N.; Shen, Yilin; Thai, My T.

2014-01-01

Community structure is one of the most commonly observed features of Online Social Networks (OSNs) in reality. The knowledge of this feature is of great advantage: it not only provides helpful insights into developing more efficient social-aware solutions but also promises a wide range of applications enabled by social and mobile networking, such as routing strategies in Mobile Ad Hoc Networks (MANETs) and worm containment in OSNs. Unfortunately, understanding this structure is very challenging, especially in dynamic social networks where social interactions are evolving rapidly. Our work focuses on the following questions: How can we efficiently identify communities in dynamic social networks? How can we adaptively update the network community structure based on its history instead of recomputing from scratch? To this end, we present Quick Community Adaptation (QCA), an adaptive modularity-based framework for not only discovering but also tracing the evolution of network communities in dynamic OSNs. QCA is very fast and efficient in the sense that it adaptively updates and discovers the new community structure based on its history together with the network changes only. This flexible approach makes QCA an ideal framework applicable for analyzing large-scale dynamic social networks due to its lightweight computing-resource requirement. To illustrate the effectiveness of our framework, we extensively test QCA on both synthesized and real-world social networks including Enron, arXiv e-print citation, and Facebook networks. Finally, we demonstrate the applicability of QCA in real applications: (1) A social-aware message forwarding strategy in MANETs, and (2) worm propagation containment in OSNs. Competitive results in comparison with other methods reveal that social-based techniques employing QCA as a community detection core outperform current available methods. PMID:24722164

Identification and characterization of a bile salt hydrolase from Lactobacillus salivarius for development of novel alternatives to antibiotic growth promoters.

PubMed

Wang, Zhong; Zeng, Ximin; Mo, Yiming; Smith, Katie; Guo, Yuming; Lin, Jun

2012-12-01

Antibiotic growth promoters (AGPs) have been used as feed additives to improve average body weight gain and feed efficiency in food animals for more than 5 decades. However, there is a worldwide trend to limit AGP use to protect food safety and public health, which raises an urgent need to discover effective alternatives to AGPs. The growth-promoting effect of AGPs has been shown to be highly correlated with the decreased activity of intestinal bile salt hydrolase (BSH), an enzyme that is produced by various gut microflora and involved in host lipid metabolism. Thus, BSH inhibitors are likely promising feed additives to AGPs to improve animal growth performance. In this study, the genome of Lactobacillus salivarius NRRL B-30514, a BSH-producing strain isolated from chicken, was sequenced by a 454 GS FLX sequencer. A BSH gene identified by genome analysis was cloned and expressed in an Escherichia coli expression system for enzymatic analyses. The BSH displayed efficient hydrolysis activity for both glycoconjugated and tauroconjugated bile salts, with slightly higher catalytic efficiencies (k(cat)/K(m)) on glycoconjugated bile salts. The optimal pH and temperature for the BSH activity were 5.5 and 41°C, respectively. Examination of a panel of dietary compounds using the purified BSH identified some potent BSH inhibitors, in which copper and zinc have been recently demonstrated to promote feed digestion and body weight gain in different food animals. In sum, this study identified and characterized a BSH with broad substrate specificity from a chicken L. salivarius strain and established a solid platform for us to discover novel BSH inhibitors, the promising feed additives to replace AGPs for enhancing the productivity and sustainability of food animals.

Discovering Air Force Identity: Airpower and Innovations

DTIC Science & Technology

2012-02-15

those of less imagination and vision who could not pierce the veil of the future and read the things which they saw.”36 The founders of American...professionals who sought to find more effective and more efficient ways and means to meet their country’s defense requirements. They were Airmen who... means and ways to execute the mission. The Airman is an innovator who executes war from above. 1 INTRODUCTION If every Marine is a rifleman, what

A Step into an eco-Compatible Future: Iron- and Cobalt-catalyzed Borrowing Hydrogen Transformation.

PubMed

Quintard, Adrien; Rodriguez, Jean

2016-01-08

Living on borrowed hydrogen: Recent developments in iron- and cobalt-catalyzed borrowing hydrogen have shown that economically reliable catalysts can be used in this type of waste-free reactions. By using well-defined inexpensive catalysts, known reactions can now be run efficiently without the necessary use of noble metals; however, in addition new types of reactivity can also be discovered. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Order priors for Bayesian network discovery with an application to malware phylogeny

DOE PAGES

Oyen, Diane; Anderson, Blake; Sentz, Kari; ...

2017-09-15

Here, Bayesian networks have been used extensively to model and discover dependency relationships among sets of random variables. We learn Bayesian network structure with a combination of human knowledge about the partial ordering of variables and statistical inference of conditional dependencies from observed data. Our approach leverages complementary information from human knowledge and inference from observed data to produce networks that reflect human beliefs about the system as well as to fit the observed data. Applying prior beliefs about partial orderings of variables is an approach distinctly different from existing methods that incorporate prior beliefs about direct dependencies (or edges)more » in a Bayesian network. We provide an efficient implementation of the partial-order prior in a Bayesian structure discovery learning algorithm, as well as an edge prior, showing that both priors meet the local modularity requirement necessary for an efficient Bayesian discovery algorithm. In benchmark studies, the partial-order prior improves the accuracy of Bayesian network structure learning as well as the edge prior, even though order priors are more general. Our primary motivation is in characterizing the evolution of families of malware to aid cyber security analysts. For the problem of malware phylogeny discovery, we find that our algorithm, compared to existing malware phylogeny algorithms, more accurately discovers true dependencies that are missed by other algorithms.« less

Order priors for Bayesian network discovery with an application to malware phylogeny

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oyen, Diane; Anderson, Blake; Sentz, Kari

Here, Bayesian networks have been used extensively to model and discover dependency relationships among sets of random variables. We learn Bayesian network structure with a combination of human knowledge about the partial ordering of variables and statistical inference of conditional dependencies from observed data. Our approach leverages complementary information from human knowledge and inference from observed data to produce networks that reflect human beliefs about the system as well as to fit the observed data. Applying prior beliefs about partial orderings of variables is an approach distinctly different from existing methods that incorporate prior beliefs about direct dependencies (or edges)more » in a Bayesian network. We provide an efficient implementation of the partial-order prior in a Bayesian structure discovery learning algorithm, as well as an edge prior, showing that both priors meet the local modularity requirement necessary for an efficient Bayesian discovery algorithm. In benchmark studies, the partial-order prior improves the accuracy of Bayesian network structure learning as well as the edge prior, even though order priors are more general. Our primary motivation is in characterizing the evolution of families of malware to aid cyber security analysts. For the problem of malware phylogeny discovery, we find that our algorithm, compared to existing malware phylogeny algorithms, more accurately discovers true dependencies that are missed by other algorithms.« less

Developing a Cloud-Based Online Geospatial Information Sharing and Geoprocessing Platform to Facilitate Collaborative Education and Research

NASA Astrophysics Data System (ADS)

Yang, Z. L.; Cao, J.; Hu, K.; Gui, Z. P.; Wu, H. Y.; You, L.

2016-06-01

Efficient online discovering and applying geospatial information resources (GIRs) is critical in Earth Science domain as while for cross-disciplinary applications. However, to achieve it is challenging due to the heterogeneity, complexity and privacy of online GIRs. In this article, GeoSquare, a collaborative online geospatial information sharing and geoprocessing platform, was developed to tackle this problem. Specifically, (1) GIRs registration and multi-view query functions allow users to publish and discover GIRs more effectively. (2) Online geoprocessing and real-time execution status checking help users process data and conduct analysis without pre-installation of cumbersome professional tools on their own machines. (3) A service chain orchestration function enables domain experts to contribute and share their domain knowledge with community members through workflow modeling. (4) User inventory management allows registered users to collect and manage their own GIRs, monitor their execution status, and track their own geoprocessing histories. Besides, to enhance the flexibility and capacity of GeoSquare, distributed storage and cloud computing technologies are employed. To support interactive teaching and training, GeoSquare adopts the rich internet application (RIA) technology to create user-friendly graphical user interface (GUI). Results show that GeoSquare can integrate and foster collaboration between dispersed GIRs, computing resources and people. Subsequently, educators and researchers can share and exchange resources in an efficient and harmonious way.

Genes@Work: an efficient algorithm for pattern discovery and multivariate feature selection in gene expression data.

PubMed

Lepre, Jorge; Rice, J Jeremy; Tu, Yuhai; Stolovitzky, Gustavo

2004-05-01

Despite the growing literature devoted to finding differentially expressed genes in assays probing different tissues types, little attention has been paid to the combinatorial nature of feature selection inherent to large, high-dimensional gene expression datasets. New flexible data analysis approaches capable of searching relevant subgroups of genes and experiments are needed to understand multivariate associations of gene expression patterns with observed phenotypes. We present in detail a deterministic algorithm to discover patterns of multivariate gene associations in gene expression data. The patterns discovered are differential with respect to a control dataset. The algorithm is exhaustive and efficient, reporting all existent patterns that fit a given input parameter set while avoiding enumeration of the entire pattern space. The value of the pattern discovery approach is demonstrated by finding a set of genes that differentiate between two types of lymphoma. Moreover, these genes are found to behave consistently in an independent dataset produced in a different laboratory using different arrays, thus validating the genes selected using our algorithm. We show that the genes deemed significant in terms of their multivariate statistics will be missed using other methods. Our set of pattern discovery algorithms including a user interface is distributed as a package called Genes@Work. This package is freely available to non-commercial users and can be downloaded from our website (http://www.research.ibm.com/FunGen).

Providing Multi-Page Data Extraction Services with XWRAPComposer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Ling; Zhang, Jianjun; Han, Wei

2008-04-30

Dynamic Web data sources – sometimes known collectively as the Deep Web – increase the utility of the Web by providing intuitive access to data repositories anywhere that Web access is available. Deep Web services provide access to real-time information, like entertainment event listings, or present a Web interface to large databases or other data repositories. Recent studies suggest that the size and growth rate of the dynamic Web greatly exceed that of the static Web, yet dynamic content is often ignored by existing search engine indexers owing to the technical challenges that arise when attempting to search the Deepmore » Web. To address these challenges, we present DYNABOT, a service-centric crawler for discovering and clustering Deep Web sources offering dynamic content. DYNABOT has three unique characteristics. First, DYNABOT utilizes a service class model of the Web implemented through the construction of service class descriptions (SCDs). Second, DYNABOT employs a modular, self-tuning system architecture for focused crawling of the Deep Web using service class descriptions. Third, DYNABOT incorporates methods and algorithms for efficient probing of the Deep Web and for discovering and clustering Deep Web sources and services through SCD-based service matching analysis. Our experimental results demonstrate the effectiveness of the service class discovery, probing, and matching algorithms and suggest techniques for efficiently managing service discovery in the face of the immense scale of the Deep Web.« less

Discovery radiomics via evolutionary deep radiomic sequencer discovery for pathologically proven lung cancer detection.

PubMed

Shafiee, Mohammad Javad; Chung, Audrey G; Khalvati, Farzad; Haider, Masoom A; Wong, Alexander

2017-10-01

While lung cancer is the second most diagnosed form of cancer in men and women, a sufficiently early diagnosis can be pivotal in patient survival rates. Imaging-based, or radiomics-driven, detection methods have been developed to aid diagnosticians, but largely rely on hand-crafted features that may not fully encapsulate the differences between cancerous and healthy tissue. Recently, the concept of discovery radiomics was introduced, where custom abstract features are discovered from readily available imaging data. We propose an evolutionary deep radiomic sequencer discovery approach based on evolutionary deep intelligence. Motivated by patient privacy concerns and the idea of operational artificial intelligence, the evolutionary deep radiomic sequencer discovery approach organically evolves increasingly more efficient deep radiomic sequencers that produce significantly more compact yet similarly descriptive radiomic sequences over multiple generations. As a result, this framework improves operational efficiency and enables diagnosis to be run locally at the radiologist's computer while maintaining detection accuracy. We evaluated the evolved deep radiomic sequencer (EDRS) discovered via the proposed evolutionary deep radiomic sequencer discovery framework against state-of-the-art radiomics-driven and discovery radiomics methods using clinical lung CT data with pathologically proven diagnostic data from the LIDC-IDRI dataset. The EDRS shows improved sensitivity (93.42%), specificity (82.39%), and diagnostic accuracy (88.78%) relative to previous radiomics approaches.

The Effect of Community on Distributed Bio-inspired Service Composition

NASA Astrophysics Data System (ADS)

Carroll, Raymond; Balasubramaniam, Sasitharan; Botvich, Dmitri; Donnelly, William

The Future Internet is expected to cater for both a larger number and variety of services, which in turn will make basic tasks such as service lifecycle management increasingly important and difficult. At the same time, the ability for users to efficiently discover and compose these services will become a key factor for service providers to differentiate themselves in a competitive market. In previous work, we examined the effect adding biological mechanisms to services had on service management and discovery. In this paper we examine the effects of community on services, specifically in terms of composing services in a distributed fashion. By introducing aspects of community we aim to demonstrate that services can further improve their sustainability and indeed their efficiency.

Three strategies for conservation

NASA Technical Reports Server (NTRS)

1975-01-01

The three strategies considered as energy conservation oriented were given: national energy conservation, electrification, and diversification. The first one applies to the near term period (now-1985), the second one to the mid term (1985-2000), and the third one to the far term (2000- ). The rest of this section was focussed on the near term period. The following proposed actions were considered: (1) roll back the price of newly discovered oil, (2) force conversion of many power plants from gas and oil to coal, (3) freeze gasoline production for three years at 1972 levels, (4) mandate automobile mileage requirements, (5) require industry to improve energy efficiency, and (6) require manufacture of household appliances with greater efficiency. Each of these six actions was described and discussed in more detail.

Pharmaceutical process chemistry: evolution of a contemporary data-rich laboratory environment.

PubMed

Caron, Stéphane; Thomson, Nicholas M

2015-03-20

Over the past 20 years, the industrial laboratory environment has gone through a major transformation in the industrial process chemistry setting. In order to discover and develop robust and efficient syntheses and processes for a pharmaceutical portfolio with growing synthetic complexity and increased regulatory expectations, the round-bottom flask and other conventional equipment familiar to a traditional organic chemistry laboratory are being replaced. The new process chemistry laboratory fosters multidisciplinary collaborations by providing a suite of tools capable of delivering deeper process understanding through mechanistic insights and detailed kinetics translating to greater predictability at scale. This transformation is essential to the field of organic synthesis in order to promote excellence in quality, safety, speed, and cost efficiency in synthesis.

Knowledge-Based Topic Model for Unsupervised Object Discovery and Localization.

PubMed

Niu, Zhenxing; Hua, Gang; Wang, Le; Gao, Xinbo

Unsupervised object discovery and localization is to discover some dominant object classes and localize all of object instances from a given image collection without any supervision. Previous work has attempted to tackle this problem with vanilla topic models, such as latent Dirichlet allocation (LDA). However, in those methods no prior knowledge for the given image collection is exploited to facilitate object discovery. On the other hand, the topic models used in those methods suffer from the topic coherence issue-some inferred topics do not have clear meaning, which limits the final performance of object discovery. In this paper, prior knowledge in terms of the so-called must-links are exploited from Web images on the Internet. Furthermore, a novel knowledge-based topic model, called LDA with mixture of Dirichlet trees, is proposed to incorporate the must-links into topic modeling for object discovery. In particular, to better deal with the polysemy phenomenon of visual words, the must-link is re-defined as that one must-link only constrains one or some topic(s) instead of all topics, which leads to significantly improved topic coherence. Moreover, the must-links are built and grouped with respect to specific object classes, thus the must-links in our approach are semantic-specific , which allows to more efficiently exploit discriminative prior knowledge from Web images. Extensive experiments validated the efficiency of our proposed approach on several data sets. It is shown that our method significantly improves topic coherence and outperforms the unsupervised methods for object discovery and localization. In addition, compared with discriminative methods, the naturally existing object classes in the given image collection can be subtly discovered, which makes our approach well suited for realistic applications of unsupervised object discovery.Unsupervised object discovery and localization is to discover some dominant object classes and localize all of object instances from a given image collection without any supervision. Previous work has attempted to tackle this problem with vanilla topic models, such as latent Dirichlet allocation (LDA). However, in those methods no prior knowledge for the given image collection is exploited to facilitate object discovery. On the other hand, the topic models used in those methods suffer from the topic coherence issue-some inferred topics do not have clear meaning, which limits the final performance of object discovery. In this paper, prior knowledge in terms of the so-called must-links are exploited from Web images on the Internet. Furthermore, a novel knowledge-based topic model, called LDA with mixture of Dirichlet trees, is proposed to incorporate the must-links into topic modeling for object discovery. In particular, to better deal with the polysemy phenomenon of visual words, the must-link is re-defined as that one must-link only constrains one or some topic(s) instead of all topics, which leads to significantly improved topic coherence. Moreover, the must-links are built and grouped with respect to specific object classes, thus the must-links in our approach are semantic-specific , which allows to more efficiently exploit discriminative prior knowledge from Web images. Extensive experiments validated the efficiency of our proposed approach on several data sets. It is shown that our method significantly improves topic coherence and outperforms the unsupervised methods for object discovery and localization. In addition, compared with discriminative methods, the naturally existing object classes in the given image collection can be subtly discovered, which makes our approach well suited for realistic applications of unsupervised object discovery.

Space-based infrared near-Earth asteroid survey simulation

NASA Astrophysics Data System (ADS)

Tedesco, Edward F.; Muinonen, Karri; Price, Stephan D.

2000-08-01

We demonstrate the efficiency and effectiveness of using a satellite-based sensor with visual and infrared focal plane arrays to search for that subclass of Near-Earth Objects (NEOs) with orbits largely interior to the Earth's orbit. A space-based visual-infrared system could detect approximately 97% of the Atens and 64% of the IEOs (the, as yet hypothetical, objects with orbits entirely Interior to Earth's Orbit) with diameters greater than 1 km in a 5-year mission and obtain orbits, albedos and diameters for all of them; the respective percentages with diameters greater than 500 m are 90% and 60%. Incidental to the search for Atens and IEOs, we found that 70% of all Earth-Crossing Asteroids (ECAs) with diameters greater than 1 km, and 50% of those with diameters greater than 500 m, would also be detected. These are the results of a feasibility study; optimizing the concept presented would result in greater levels of completion. The cost of such a space-based system is estimated to be within a factor of two of the cost of a ground-based system capable of about 21st magnitude, which would provide only orbits and absolute magnitudes and require decades to reach these completeness levels. In addition to obtaining albedos and diameters for the asteroids discovered in the space-based survey, a space-based visual-infrared system would obtain the same information on virtually all NEOs of interest. A combined space-based and ground-based survey would be highly synergistic in that each can concentrate on what it does best and each complements the strengths of the other. The ground-based system would discover the majority of Amors and Apollos and provide long-term follow-up on all the NEOs discovered in both surveys. The space-based system would discover the majority of Atens and IEOs and provide albedos and diameters on all the NEOs discovered in both surveys and most previously discovered NEOs as well. Thus, an integrated ground- and space-based system could accomplish the Spaceguard goal in less time than the ground-based system alone. In addition, the result would be a catalog containing well-determined orbits, diameters, and albedos for the majority of ECAs with diameters greater than 500 m.

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

PubMed

McCoull, William; Addie, Matthew S; Birch, Alan M; Birtles, Susan; Buckett, Linda K; Butlin, Roger J; Bowker, Suzanne S; Boyd, Scott; Chapman, Stephen; Davies, Robert D M; Donald, Craig S; Green, Clive P; Jenner, Chloe; Kemmitt, Paul D; Leach, Andrew G; Moody, Graeme C; Gutierrez, Pablo Morentin; Newcombe, Nicholas J; Nowak, Thorsten; Packer, Martin J; Plowright, Alleyn T; Revill, John; Schofield, Paul; Sheldon, Chris; Stokes, Steve; Turnbull, Andrew V; Wang, Steven J Y; Whalley, David P; Wood, J Matthew

2012-06-15

A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clinical in vivo efficacy that could be rationalised through a PK/PD relationship. Copyright © 2012 Elsevier Ltd. All rights reserved.

A Look Inside Argonne's Center for Nanoscale Materials

ScienceCinema

Divan, Ralu; Rosenthal, Dan; Rose, Volker; Wai Hla

2018-05-23

At a very small, or "nano" scale, materials behave differently. The study of nanomaterials is much more than miniaturization - scientists are discovering how changes in size change a material's properties. From sunscreen to computer memory, the applications of nanoscale materials research are all around us. Researchers at Argonne's Center for Nanoscale Materials are creating new materials, methods and technologies to address some of the world's greatest challenges in energy security, lightweight but durable materials, high-efficiency lighting, information storage, environmental stewardship and advanced medical devices.

Geologic utility of small-scale airphotos

NASA Technical Reports Server (NTRS)

Clark, M. M.

1969-01-01

The geologic value of small scale airphotos is emphasized by describing the application of high altitude oblique and 1:120,000 to 1:145,000 scale vertical airphotos to several geologic problems in California. These examples show that small-scale airphotos can be of use to geologists in the following ways: (1) high altitude, high oblique airphotos show vast areas in one view; and (2) vertical airphotos offer the most efficient method of discovering the major topographic features and structural and lithologic characteristics of terrain.

Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

PubMed Central

2015-01-01

Catalytic conditions for the α-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines. PMID:26584680

Ultrafast time-resolved spectroscopy of lead halide perovskite films

NASA Astrophysics Data System (ADS)

Idowu, Mopelola A.; Yau, Sung H.; Varnavski, Oleg; Goodson, Theodore

2015-09-01

Recently, lead halide perovskites which are organic-inorganic hybrid structures, have been discovered to be highly efficient as light absorbers. Herein, we show the investigation of the excited state dynamics and emission properties of non-stoichiometric precursor formed lead halide perovskites grown by interdiffusion method using steady-state and time-resolved spectroscopic measurements. The influence of the different ratios of the non-stoichiometric precursor solution was examined. The observed photoluminescence properties were correlated with the femtosecond transient absorption measurements.

Protecting Superconducting HTS-Antennas by Meta-Material Cloaks

DTIC Science & Technology

2014-04-30

radiation efficiency for this antenna is 22.3\\%. However, if the normal conducting part is replaced with a superconductor , e.g. YBCO with RS=500µΩ, [8] the...loss resistance can be brought down due to the much lower surface resistance of the superconductor relative to the normal conductor. Chalupka et al...range [12]. In 1987, Wu et al. [13] discovered the HTS compound YBCO that has a TC of ≈ 92K, which was the first superconductor to have a TC greater

N,N-Diethylurea-Catalyzed Amidation between Electron-Defficient Aryl Azides and Phenylacetaldehydes

PubMed Central

Xie, Sheng; Ramström, Olof; Yan, Mingdi

2015-01-01

Urea structures, of which N,N-diethylurea (DEU) proved to be the most efficient, were discovered to catalyze amidation reactions between electron-defficient aryl azides and phenylacetaldehydes. Experimental data support 1,3-dipolar cycloaddition between DEU-activated enols and electrophilic phenyl azides, especially perfluoroaryl azides, followed by rearrangement of the triazoline intermediate. The activation of the aldehyde under near-neutral conditions was of special importance in inhibiting dehydration/aromatization of the triazoline intermediate, thus promoting the rearrangement to form aryl amides. PMID:25616121

Growth in conventional fields in high-cost areas: a case study

USGS Publications Warehouse

Attanasi, E.D.

2000-01-01

Exploration managers commonly base future drilling decisions on past experience in an area. To do this well, they should consider both discovered and undiscovered resources to characterize total future potential. Discovery-size estimates should be adjusted to account for future field growth; otherwise, the relative efficiency of recent exploration will be undervalued. This study models and projects field growth for pre-1997 discoveries in the U.S. Federal Gulf of Mexico (GOM) Outer Continental Shelf (OCS). Projected additions to reserves for these fields from field growth through 2020 are 5.2 billion bbl of oil and 46 Tcfg. Projections include growth associated with sizable new oil discoveries in deepwater areas and initial reserve additions from new subsalt plays discovered through 1996. This article focuses on the U.S. GOM because it has produced longer than other worldwide offshore areas. Its field-growth profile may be prototypical of other offshore provinces such as the North Sea, Scotian Shelf and deepwater Angola, as well as high-cost onshore areas.

BCube: Building a Geoscience Brokering Framework

NASA Astrophysics Data System (ADS)

Jodha Khalsa, Siri; Nativi, Stefano; Duerr, Ruth; Pearlman, Jay

2014-05-01

BCube is addressing the need for effective and efficient multi-disciplinary collaboration and interoperability through the advancement of brokering technologies. As a prototype "building block" for NSF's EarthCube cyberinfrastructure initiative, BCube is demonstrating how a broker can serve as an intermediary between information systems that implement well-defined interfaces, thereby providing a bridge between communities that employ different specifications. Building on the GEOSS Discover and Access Broker (DAB), BCube will develop new modules and services including: • Expanded semantic brokering capabilities • Business Model support for work flows • Automated metadata generation • Automated linking to services discovered via web crawling • Credential passing for seamless access to data • Ranking of search results from brokered catalogs Because facilitating cross-discipline research involves cultural and well as technical challenges, BCube is also addressing the sociological and educational components of infrastructure development. We are working, initially, with four geoscience disciplines: hydrology, oceans, polar and weather, with an emphasis on connecting existing domain infrastructure elements to facilitate cross-domain communications.

Electrocatalytic Alloys for CO2 Reduction.

PubMed

He, Jingfu; Johnson, Noah J J; Huang, Aoxue; Berlinguette, Curtis P

2018-01-10

Electrochemically reducing CO 2 using renewable energy is a contemporary global challenge that will only be met with electrocatalysts capable of efficiently converting CO 2 into fuels and chemicals with high selectivity. Although many different metals and morphologies have been tested for CO 2 electrocatalysis over the last several decades, relatively limited attention has been committed to the study of alloys for this application. Alloying is a promising method to tailor the geometric and electric environments of active sites. The parameter space for discovering new alloys for CO 2 electrocatalysis is particularly large because of the myriad products that can be formed during CO 2 reduction. In this Minireview, mixed-metal electrocatalyst compositions that have been evaluated for CO 2 reduction are summarized. A distillation of the structure-property relationships gleaned from this survey are intended to help in the construction of guidelines for discovering new classes of alloys for the CO 2 reduction reaction. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Discovering Link Communities in Complex Networks by an Integer Programming Model and a Genetic Algorithm

PubMed Central

Li, Zhenping; Zhang, Xiang-Sun; Wang, Rui-Sheng; Liu, Hongwei; Zhang, Shihua

2013-01-01

Identification of communities in complex networks is an important topic and issue in many fields such as sociology, biology, and computer science. Communities are often defined as groups of related nodes or links that correspond to functional subunits in the corresponding complex systems. While most conventional approaches have focused on discovering communities of nodes, some recent studies start partitioning links to find overlapping communities straightforwardly. In this paper, we propose a new quantity function for link community identification in complex networks. Based on this quantity function we formulate the link community partition problem into an integer programming model which allows us to partition a complex network into overlapping communities. We further propose a genetic algorithm for link community detection which can partition a network into overlapping communities without knowing the number of communities. We test our model and algorithm on both artificial networks and real-world networks. The results demonstrate that the model and algorithm are efficient in detecting overlapping community structure in complex networks. PMID:24386268

CRISPR/Cas9 for cancer research and therapy.

PubMed

Zhan, Tianzuo; Rindtorff, Niklas; Betge, Johannes; Ebert, Matthias P; Boutros, Michael

2018-04-16

CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First discovered in bacteria as part of an adaptive immune system, CRISPR/Cas9 and modified versions have found a widespread use to engineer genomes and to activate or to repress the expression of genes. As such, CRISPR/Cas9 promises to accelerate cancer research by providing an efficient technology to dissect mechanisms of tumorigenesis, identify targets for drug development, and possibly arm cells for cell-based therapies. Here, we review current applications of the CRISPR/Cas9 technology for cancer research and therapy. We describe novel Cas9 variants and how they are used in functional genomics to discover novel cancer-specific vulnerabilities. Furthermore, we highlight the impact of CRISPR/Cas9 in generating organoid and mouse models of cancer. Finally, we provide an overview of the first clinical trials that apply CRISPR/Cas9 as a therapeutic approach against cancer. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Design and assessment of engineered CRISPR-Cpf1 and its use for genome editing.

PubMed

Li, Bin; Zeng, Chunxi; Dong, Yizhou

2018-05-01

Cpf1, a CRISPR endonuclease discovered in Prevotella and Francisella 1 bacteria, offers an alternative platform for CRISPR-based genome editing beyond the commonly used CRISPR-Cas9 system originally discovered in Streptococcus pyogenes. This protocol enables the design of engineered CRISPR-Cpf1 components, both CRISPR RNAs (crRNAs) to guide the endonuclease and Cpf1 mRNAs to express the endonuclease protein, and provides experimental procedures for effective genome editing using this system. We also describe quantification of genome-editing activity and off-target effects of the engineered CRISPR-Cpf1 in human cell lines using both T7 endonuclease I (T7E1) assay and targeted deep sequencing. This protocol enables rapid construction and identification of engineered crRNAs and Cpf1 mRNAs to enhance genome-editing efficiency using the CRISPR-Cpf1 system, as well as assessment of target specificity within 2 months. This protocol may also be appropriate for fine-tuning other types of CRISPR systems.

Advanced Cell Classifier: User-Friendly Machine-Learning-Based Software for Discovering Phenotypes in High-Content Imaging Data.

PubMed

Piccinini, Filippo; Balassa, Tamas; Szkalisity, Abel; Molnar, Csaba; Paavolainen, Lassi; Kujala, Kaisa; Buzas, Krisztina; Sarazova, Marie; Pietiainen, Vilja; Kutay, Ulrike; Smith, Kevin; Horvath, Peter

2017-06-28

High-content, imaging-based screens now routinely generate data on a scale that precludes manual verification and interrogation. Software applying machine learning has become an essential tool to automate analysis, but these methods require annotated examples to learn from. Efficiently exploring large datasets to find relevant examples remains a challenging bottleneck. Here, we present Advanced Cell Classifier (ACC), a graphical software package for phenotypic analysis that addresses these difficulties. ACC applies machine-learning and image-analysis methods to high-content data generated by large-scale, cell-based experiments. It features methods to mine microscopic image data, discover new phenotypes, and improve recognition performance. We demonstrate that these features substantially expedite the training process, successfully uncover rare phenotypes, and improve the accuracy of the analysis. ACC is extensively documented, designed to be user-friendly for researchers without machine-learning expertise, and distributed as a free open-source tool at www.cellclassifier.org. Copyright © 2017 Elsevier Inc. All rights reserved.

[Research advances in mechanism of high phosphorus use efficiency of plants].

PubMed

Ma, Xiangqing; Liang, Xia

2004-04-01

Phosphorus deficiency is one of the main factors influencing agricultural and forestry productions. Fertilization and soil improvement are the major measures to meet the demand of phosphorus for crops in traditional agriculture and forestry management. Recently, the plants with high phosphorus use efficiency have been discovered to replace the traditional measures to improve phosphorus use efficiency of crops. This paper reviewed the research advances in the morphological, physiological and genetics mechanisms of plants with high phosphorus use efficiency. There were three mechanisms for the plants with high phosphorus use efficiency to grow under phosphorus stress: (1) under low phosphorus stress, the root morphology would change (root system grew fast, root axes became small, the number and density of lateral root increased) and more photosynthesis products would transport from the crown to the root, (2) under low phosphorus stress, plant root exudation increased, mycorrhizae invaded into root system, the feature of root absorption kinetics changed, and the internal phosphorus cycling of plant reinforced to tolerate phosphorus deficiency, and (3) under long selection stress of low phosphorus, some plants would form the genetic properties of phosphorus nutrition that could exploit the hardly soluble phosphorus in the soil.

Ionization Efficiency of Doubly Charged Ions Formed from Polyprotic Acids in Electrospray Negative Mode

NASA Astrophysics Data System (ADS)

Liigand, Piia; Kaupmees, Karl; Kruve, Anneli

2016-07-01

The ability of polyprotic acids to give doubly charged ions in negative mode electrospray was studied and related to physicochemical properties of the acids via linear discriminant analysis (LDA). It was discovered that the compound has to be strongly acidic (low p K a1 and p K a2) and to have high hydrophobicity (log P ow) to become multiply charged. Ability to give multiply charged ions in ESI/MS cannot be directly predicted from the solution phase acidities. Therefore, for the first time, a quantitative model to predict the charge state of the analyte in ESI/MS is proposed and validated for small anions. Also, a model to predict ionization efficiencies of these analytes was developed. Results indicate that acidity of the analyte, its octanol-water partition coefficient, and charge delocalization are important factors that influence ionization efficiencies as well as charge states of the analytes. The pH of the solvent was also found to be an important factor influencing the ionization efficiency of doubly charged ions.

[Physics of materials and female stress urinary continence: New concepts: I) Elasticity under bladder].

PubMed

Guerquin, B

2015-09-01

Improving the understanding of the adaptation to stress of urinary continence. A transversal analysis between physics of materials and the female anatomy. Laws of physics of the materials and of their viscoelastic behavior are applied to the anatomy of the anterior vaginal wall. The anterior vaginal wall may be divided into two segments of different viscoelastic behavior, the vertical segment below the urethra and the horizontal segment below the bladder. If the urethra gets crushed on the first segment according to the hammock theory, the crushing of the bladder on the second segment is, on the other hand, damped by its important elasticity. The importance of this elasticity evokes an unknown function: damping under the bladder that moderates and delays the increase of intravesical pressure. This damping function below the bladder is increased in the cystocele, which is therefore a continence factor; on the other hand, it is impaired in obesity, which is therefore a factor of SUI. It is necessary to include in the theory of stress continence, the notion of a damping function below the bladder. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

KSC-07pd1855

NASA Image and Video Library

2007-07-11

KENNEDY SPACE CENTER, FLA. -- A gopher tortoise searches for food at the edge of a road near Launch Pad 39A. Their primary food sources are low-growing grasses and herbs, with their favorite foods being gopher apple and saw palmetto berries. They will eat the pads, fruits, and flowers of prickly pear cactus as well. They will occasionally also eat bones from dead animals, presumably to get calcium. The gopher tortoise is a cold-blooded reptile that averages 10 inches in length and 9 pounds in weight. Wild tortoises may live from 40 - 60 years, while tortoises in captivity can live more than 100 years. Their range extends from southeastern Louisiana to southeastern South Carolina and throughout all 67 counties in Florida. The gopher tortoise is federally protected as a threatened species except in Florida, where it is listed as a Species of Special Concern by the Florida Fish and Wildlife Conservation Commission. Lands surrounding the Kennedy Space Center are part of the Merritt Island National Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks. Photo credit: NASA/Ken Thornsley

KSC-07pd1856

NASA Image and Video Library

2007-07-11

KENNEDY SPACE CENTER, FLA. -- A gopher tortoise searches for food at the edge of a road near Launch Pad 39A. Their primary food sources are low-growing grasses and herbs, with their favorite foods being gopher apple and saw palmetto berries. They will eat the pads, fruits, and flowers of prickly pear cactus as well. They will occasionally also eat bones from dead animals, presumably to get calcium. The gopher tortoise is a cold-blooded reptile that averages 10 inches in length and 9 pounds in weight. Wild tortoises may live from 40 - 60 years, while tortoises in captivity can live more than 100 years. Their range extends from southeastern Louisiana to southeastern South Carolina and throughout all 67 counties in Florida. The gopher tortoise is federally protected as a threatened species except in Florida, where it is listed as a Species of Special Concern by the Florida Fish and Wildlife Conservation Commission. Lands surrounding the Kennedy Space Center are part of the Merritt Island National Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks. Photo credit: NASA/Ken Thornsley

KSC-07pd1857

NASA Image and Video Library

2007-07-11

KENNEDY SPACE CENTER, FLA. -- A gopher tortoise searches for food at the edge of a road near Launch Pad 39A. Their primary food sources are low-growing grasses and herbs, with their favorite foods being gopher apple and saw palmetto berries. They will eat the pads, fruits, and flowers of prickly pear cactus as well. They will occasionally also eat bones from dead animals, presumably to get calcium. The gopher tortoise is a cold-blooded reptile that averages 10 inches in length and 9 pounds in weight. Wild tortoises may live from 40 - 60 years, while tortoises in captivity can live more than 100 years. Their range extends from southeastern Louisiana to southeastern South Carolina and throughout all 67 counties in Florida. The gopher tortoise is federally protected as a threatened species except in Florida, where it is listed as a Species of Special Concern by the Florida Fish and Wildlife Conservation Commission. Lands surrounding the Kennedy Space Center are part of the Merritt Island National Wildlife Refuge. Approximately one half of the Refuge's 140,000 acres consists of brackish estuaries and marshes. The remaining lands consist of coastal dunes, scrub oaks, pine forests and flatwoods, and palm and oak hammocks. Photo credit: NASA/Ken Thornsley

Sequential decision making in computational sustainability via adaptive submodularity

USGS Publications Warehouse

Krause, Andreas; Golovin, Daniel; Converse, Sarah J.

2015-01-01

Many problems in computational sustainability require making a sequence of decisions in complex, uncertain environments. Such problems are generally notoriously difficult. In this article, we review the recently discovered notion of adaptive submodularity, an intuitive diminishing returns condition that generalizes the classical notion of submodular set functions to sequential decision problems. Problems exhibiting the adaptive submodularity property can be efficiently and provably near-optimally solved using simple myopic policies. We illustrate this concept in several case studies of interest in computational sustainability: First, we demonstrate how it can be used to efficiently plan for resolving uncertainty in adaptive management scenarios. Secondly, we show how it applies to dynamic conservation planning for protecting endangered species, a case study carried out in collaboration with the US Geological Survey and the US Fish and Wildlife Service.

Physical methods for genetic transformation of fungi and yeast

NASA Astrophysics Data System (ADS)

Rivera, Ana Leonor; Magaña-Ortíz, Denis; Gómez-Lim, Miguel; Fernández, Francisco; Loske, Achim M.

2014-06-01

The production of transgenic fungi is a routine process. Currently, it is possible to insert genes from other fungi, viruses, bacteria and even animals, albeit with low efficiency, into the genomes of a number of fungal species. Genetic transformation requires the penetration of the transgene through the fungal cell wall, a process that can be facilitated by biological or physical methods. Novel methodologies for the efficient introduction of specific genes and stronger promoters are needed to increase production levels. A possible solution to this problem is the recently discovered shock-wave-mediated transformation. The objective of this article is to review the state of the art of the physical methods used for genetic fungi transformation and to describe some of the basic physics and molecular biology behind them.

Specially Treated Aramid Fiber Stabilized Gel-Emulsions: Preparation of Porous Polymeric Monoliths and Highly Efficient Removing of Airborne HCHO.

PubMed

Liu, Jianfei; Chen, Xiangli; Wang, Pei; Fu, Xuwei; Liu, Kaiqiang; Fang, Yu

2017-08-01

Porous polymeric monoliths with densities as low as ≈0.060 g cm -3 are prepared in a gel-emulsion template way, of which the stabilizer employed is a newly discovered acidified aramid fiber that is so efficient that 0.05% (w/v, accounts for continuous phase) is enough to gel the system. The porous monoliths as obtained can be dried at ambient conditions, avoiding energy-consuming processes. Importantly, the monoliths show selective adsorption to HCHO, and the corresponding adsorption capacity (M6) is ≈2700 mg g -1 , the best result that is reported until now. More importantly, the monoliths can be reused after drying. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Flexo-photovoltaic effect

NASA Astrophysics Data System (ADS)

Yang, Ming-Min; Kim, Dong Jik; Alexe, Marin

2018-05-01

It is highly desirable to discover photovoltaic mechanisms that enable enhanced efficiency of solar cells. Here we report that the bulk photovoltaic effect, which is free from the thermodynamic Shockley-Queisser limit but usually manifested only in noncentrosymmetric (piezoelectric or ferroelectric) materials, can be realized in any semiconductor, including silicon, by mediation of flexoelectric effect. We used either an atomic force microscope or a micrometer-scale indentation system to introduce strain gradients, thus creating very large photovoltaic currents from centrosymmetric single crystals of strontium titanate, titanium dioxide, and silicon. This strain gradient–induced bulk photovoltaic effect, which we call the flexo-photovoltaic effect, functions in the absence of a p-n junction. This finding may extend present solar cell technologies by boosting the solar energy conversion efficiency from a wide pool of established semiconductors.

The impact of the weather conditions on the cooling performance of the heat pump driven by an internal natural gas combustion engine

NASA Astrophysics Data System (ADS)

Janovcová, Martina; Jandačka, Jozef; Malcho, Milan

2015-05-01

Market with sources of heat and cold offers unlimited choice of different power these devices, design technology, efficiency and price categories. New progressive technologies are constantly discovering, about which is still little information, which include heat pumps powered by a combustion engine running on natural gas. A few pieces of these installations are in Slovakia, but no studies about their work and effectiveness under real conditions. This article deals with experimental measurements of gas heat pump efficiency in cooling mode. Since the gas heat pump works only in system air - water, air is the primary low - energy source, it is necessary to monitor the impact of the climate conditions for the gas heat pump performance.

Focused Crawling of the Deep Web Using Service Class Descriptions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rocco, D; Liu, L; Critchlow, T

2004-06-21

Dynamic Web data sources--sometimes known collectively as the Deep Web--increase the utility of the Web by providing intuitive access to data repositories anywhere that Web access is available. Deep Web services provide access to real-time information, like entertainment event listings, or present a Web interface to large databases or other data repositories. Recent studies suggest that the size and growth rate of the dynamic Web greatly exceed that of the static Web, yet dynamic content is often ignored by existing search engine indexers owing to the technical challenges that arise when attempting to search the Deep Web. To address thesemore » challenges, we present DynaBot, a service-centric crawler for discovering and clustering Deep Web sources offering dynamic content. DynaBot has three unique characteristics. First, DynaBot utilizes a service class model of the Web implemented through the construction of service class descriptions (SCDs). Second, DynaBot employs a modular, self-tuning system architecture for focused crawling of the DeepWeb using service class descriptions. Third, DynaBot incorporates methods and algorithms for efficient probing of the Deep Web and for discovering and clustering Deep Web sources and services through SCD-based service matching analysis. Our experimental results demonstrate the effectiveness of the service class discovery, probing, and matching algorithms and suggest techniques for efficiently managing service discovery in the face of the immense scale of the Deep Web.« less

Frequency and time domain studies of magneto-transport and charge trapping in amorphous organic semiconductors

NASA Astrophysics Data System (ADS)

Rybicki, James Edward

The focus of this thesis is a recently discovered organic magnetoresistance (OMAR) whose underlying mechanism remains much debated. As an introduction, the field of organic electronic is briefly discussed focusing mainly on organic light emitting diodes, the devices in which OMAR was first discovered. Important findings related to OMAR from prior work are highlighted and several proposed models for the underlying mechanism are discussed. The frequency dependence of OMAR along with capacitance spectroscopy are studied to help distinguish between proposed models. The limit frequency for OMAR devices is obtained. Magnetic field dependent time-of-flight spectroscopy is used to determine whether applied magnetic fields modify the photocarrier generation efficiency in OMAR devices, their mobility, or both. These results are used to compare the bipolaron model and the triplet-polaron scattering mechanism. As it is generally agreed that OMAR is a spintronic effect, the role of spin-orbit coupling in polymers was studied to help understand its importance in the spin-transport of organic semiconductors. The possibility of spin-orbit induced spin precession is examined and a phonon assisted spin-flip process is proposed. We show OMAR may be enhanced by exposure to x-ray radiation. This is shown to be related to the production of traps. The effect on other device characteristics including turn-voltage and quantum efficiency is also examined. The role of trap production in enhancing OMAR is explained using the biopolaron model.

Quality of the log-geometric distribution extrapolation for smaller undiscovered oil and gas pool size

USGS Publications Warehouse

Chenglin, L.; Charpentier, R.R.

2010-01-01

The U.S. Geological Survey procedure for the estimation of the general form of the parent distribution requires that the parameters of the log-geometric distribution be calculated and analyzed for the sensitivity of these parameters to different conditions. In this study, we derive the shape factor of a log-geometric distribution from the ratio of frequencies between adjacent bins. The shape factor has a log straight-line relationship with the ratio of frequencies. Additionally, the calculation equations of a ratio of the mean size to the lower size-class boundary are deduced. For a specific log-geometric distribution, we find that the ratio of the mean size to the lower size-class boundary is the same. We apply our analysis to simulations based on oil and gas pool distributions from four petroleum systems of Alberta, Canada and four generated distributions. Each petroleum system in Alberta has a different shape factor. Generally, the shape factors in the four petroleum systems stabilize with the increase of discovered pool numbers. For a log-geometric distribution, the shape factor becomes stable when discovered pool numbers exceed 50 and the shape factor is influenced by the exploration efficiency when the exploration efficiency is less than 1. The simulation results show that calculated shape factors increase with those of the parent distributions, and undiscovered oil and gas resources estimated through the log-geometric distribution extrapolation are smaller than the actual values. ?? 2010 International Association for Mathematical Geology.

Long-range dismount activity classification: LODAC

NASA Astrophysics Data System (ADS)

Garagic, Denis; Peskoe, Jacob; Liu, Fang; Cuevas, Manuel; Freeman, Andrew M.; Rhodes, Bradley J.

2014-06-01

Continuous classification of dismount types (including gender, age, ethnicity) and their activities (such as walking, running) evolving over space and time is challenging. Limited sensor resolution (often exacerbated as a function of platform standoff distance) and clutter from shadows in dense target environments, unfavorable environmental conditions, and the normal properties of real data all contribute to the challenge. The unique and innovative aspect of our approach is a synthesis of multimodal signal processing with incremental non-parametric, hierarchical Bayesian machine learning methods to create a new kind of target classification architecture. This architecture is designed from the ground up to optimally exploit correlations among the multiple sensing modalities (multimodal data fusion) and rapidly and continuously learns (online self-tuning) patterns of distinct classes of dismounts given little a priori information. This increases classification performance in the presence of challenges posed by anti-access/area denial (A2/AD) sensing. To fuse multimodal features, Long-range Dismount Activity Classification (LODAC) develops a novel statistical information theoretic approach for multimodal data fusion that jointly models multimodal data (i.e., a probabilistic model for cross-modal signal generation) and discovers the critical cross-modal correlations by identifying components (features) with maximal mutual information (MI) which is efficiently estimated using non-parametric entropy models. LODAC develops a generic probabilistic pattern learning and classification framework based on a new class of hierarchical Bayesian learning algorithms for efficiently discovering recurring patterns (classes of dismounts) in multiple simultaneous time series (sensor modalities) at multiple levels of feature granularity.

Metabolomic response of a marine bacterium to 3,6-anhydro-l-galactose, the rare sugar from red macroalgae, as the sole carbon source.

PubMed

Yun, Eun Ju; Yu, Sora; Kim, Sooah; Kim, Kyoung Heon

2018-03-20

Marine red macroalgae have received much attention as sustainable resources for producing bio-based products. Therefore, understanding the metabolic pathways of carbohydrates from red macroalgae, in fermentative microorganisms, is crucial for efficient bioconversion of the carbohydrates into bio-based products. Recently, the novel catabolic pathway of 3,6-anhydro-l-galactose (AHG), the main component of red macroalgae, was discovered in a marine bacterium, Vibrio sp. strain EJY3. However, the global metabolic network in response to AHG remains unclear. Here, the intracellular metabolites of EJY3 grown on AHG, glucose, or galactose were comparatively profiled using gas chromatography/time-of-flight mass spectrometry. The global metabolite profiling results revealed that the metabolic profile for AHG significantly differed from those for other common sugars. Specifically, the metabolic intermediate of the AHG pathway, 3,6-anhydrogalactonate, was detected during growth only in the presence of AHG; thus, the recently discovered key steps in AHG catabolism was found not to occur in the catabolism of other common sugars. Moreover, the levels of metabolic intermediates related to glycerolipid metabolism and valine biosynthesis were higher with AHG than those with other sugars. These comprehensive metabolomic analytical results for AHG in this marine bacterium can be used as the basis for having fermentative microbial strains to engineered to efficiently utilize AHG from macroalgal biomass. Copyright © 2018 Elsevier B.V. All rights reserved.

Ffuzz: Towards full system high coverage fuzz testing on binary executables

PubMed Central

2018-01-01

Bugs and vulnerabilities in binary executables threaten cyber security. Current discovery methods, like fuzz testing, symbolic execution and manual analysis, both have advantages and disadvantages when exercising the deeper code area in binary executables to find more bugs. In this paper, we designed and implemented a hybrid automatic bug finding tool—Ffuzz—on top of fuzz testing and selective symbolic execution. It targets full system software stack testing including both the user space and kernel space. Combining these two mainstream techniques enables us to achieve higher coverage and avoid getting stuck both in fuzz testing and symbolic execution. We also proposed two key optimizations to improve the efficiency of full system testing. We evaluated the efficiency and effectiveness of our method on real-world binary software and 844 memory corruption vulnerable programs in the Juliet test suite. The results show that Ffuzz can discover software bugs in the full system software stack effectively and efficiently. PMID:29791469

Enrichment of serum biomarkers by magnetic metal-organic framework composites.

PubMed

Wei, Ji-Ping; Wang, Heng; Luo, Tao; Zhou, Zhi-Jiang; Huang, Yan-Feng; Qiao, Bin

2017-03-01

Highly efficient extraction of peptides from serum is critical for finding serum biomarkers using mass spectrometry, which still remains a great challenge. Currently, a bottom-up proteomics approach has been applied to discover serum biomarkers. However, the approach was labor intensive, time and cost consuming, and cannot meet the requirements for clinical application. In this work, Fe 3 O 4 /C@MIL-100 composites were synthesized to efficiently capture peptides from microwave-assisted formic acid digests of BSA and human serum prior to MALDI-TOF MS analysis. Fe 3 O 4 /C@MIL-100 composites exhibited size-selective adsorption performance, thus providing a rapid and convenient approach to enrich low-abundance peptides. Notably, the peptides' mass fingerprinting of serum digestions between type 2 diabetes mellitus (T2DM) and healthy persons were distinguishable, which indicated the potential ability of this technique for T2DM diagnosis and rapid biomarker discovery. Graphical Abstract Efficient extraction and identification of serum biomarkers using Fe 3 O 4 /C@MIL-100 composites from acid hydrolysate.

Chromatic effect in a novel THz generation scheme

NASA Astrophysics Data System (ADS)

Li, Bin; Zhang, Wenyan; Liu, Xiaoqing; Deng, Haixiao; Lan, Taihe; Liu, Bo; Liu, Jia; Wang, Xingtao; Zeng, Zhinan; Zhang, Lijian

2017-11-01

Deriving single or few cycle terahertz (THz) pulse by an intense femtosecond laser through cascaded optical rectification is a crucial technique in cutting-edge time-resolved spectroscopy to characterize micro-scale structures and ultrafast dynamics. Due to the broadband nature of the ultrafast driving laser, the chromatic effect limits the THz conversion efficiency in optical rectification crystals, especially for those implementing the pulse-front tilt scheme, e.g. lithium niobate (LN) crystal, has been prevalently used in the past decade. In this research we developed a brand new type of LN crystal utilizing Brewster coupling, and conducted systematically experimental and simulative investigation for the chromatic effect and multi-dimensionally entangled parameters in THz generation, predicting that an extreme conversion efficiency of ˜10% would be potentially achievable at the THz absorption coefficient of ˜0.5 cm-1. Moreover, we first discovered that the chirp of the driving laser plays a decisive role in the pulse-front tilt scheme, and the THz generation efficiency could be enhanced tremendously by applying an appropriate chirp.

Measurement of fast neutron detection efficiency with 6Li and 7Li enriched CLYC scintillators

NASA Astrophysics Data System (ADS)

Mentana, A.; Camera, F.; Giaz, A.; Blasi, N.; Brambilla, S.; Ceruti, S.; Gini, L.; Groppi, F.; Manenti, S.; Million, B.; Riboldi, S.

2016-10-01

The CLYC (Cs2LiYC6:Ce) crystal belongs to the elpasolite scintillator family, discovered about 15 years ago. It is a very interesting material because of its good energy resolution and its capability to identify and measure gamma rays and fast/thermal neutrons. In the present work, the fast neutron detection efficiency for two different CLYC cylindrical samples has been measured. These two crystals, both with dimension (thickness x diameter) 1”×1”, were respectively enriched with more than 99% of 7Li (CLYC-7) and with ∼ 95% of 6Li (CLYC-6). The presence of the 6Li isotope makes the CLYC-6 ideal to detect thermal neutrons. In order to compare the two scintillators, only the detection efficiency for fast neutrons was considered, neglecting the energy region associated to thermal neutrons in both the crystals. The measurement was performed at the L.A.S.A. Laboratory of INFN and University of Milano (Italy), using a 241Am-Be source.

Asymmetry in Signal Oscillations Contributes to Efficiency of Periodic Systems.

PubMed

Bae, Seul-A; Acevedo, Alison; Androulakis, Ioannis P

2016-01-01

Oscillations are an important feature of cellular signaling that result from complex combinations of positive- and negative-feedback loops. The encoding and decoding mechanisms of oscillations based on amplitude and frequency have been extensively discussed in the literature in the context of intercellular and intracellular signaling. However, the fundamental questions of whether and how oscillatory signals offer any competitive advantages-and, if so, what-have not been fully answered. We investigated established oscillatory mechanisms and designed a study to analyze the oscillatory characteristics of signaling molecules and system output in an effort to answer these questions. Two classic oscillators, Goodwin and PER, were selected as the model systems, and corresponding no-feedback models were created for each oscillator to discover the advantage of oscillating signals. Through simulating the original oscillators and the matching no-feedback models, we show that oscillating systems have the capability to achieve better resource-to-output efficiency, and we identify oscillatory characteristics that lead to improved efficiency.

The impact of software quality characteristics on healthcare outcome: a literature review.

PubMed

Aghazadeh, Sakineh; Pirnejad, Habibollah; Moradkhani, Alireza; Aliev, Alvosat

2014-01-01

The aim of this study was to discover the effect of software quality characteristics on healthcare quality and efficiency indicators. Through a systematic literature review, we selected and analyzed 37 original research papers to investigate the impact of the software indicators (coming from the standard ISO 9126 quality characteristics and sub-characteristics) on some of healthcare important outcome indicators and finally ranked these software indicators. The results showed that the software characteristics usability, reliability and efficiency were mostly favored in the studies, indicating their importance. On the other hand, user satisfaction, quality of patient care, clinical workflow efficiency, providers' communication and information exchange, patient satisfaction and care costs were among the healthcare outcome indicators frequently evaluated in relation to the mentioned software characteristics. Regression Logistic Method was the most common assessment methodology, and Confirmatory Factor Analysis and Structural Equation Modeling were performed to test the structural model's fit. The software characteristics were considered to impact the healthcare outcome indicators through other intermediate factors (variables).

Identification of sequence motifs significantly associated with antisense activity.

PubMed

McQuisten, Kyle A; Peek, Andrew S

2007-06-07

Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive model, it is important to know what properties of an oligonucleotide sequence associate significantly with antisense activity. Also, for the model to be efficient we must know what properties do not associate significantly and can be omitted from the model. This paper will discuss the results of a randomization procedure to find motifs that associate significantly with either high or low antisense suppression activity, analysis of their properties, as well as the results of support vector machine modelling using these significant motifs as features. We discovered 155 motifs that associate significantly with high antisense suppression activity and 202 motifs that associate significantly with low suppression activity. The motifs range in length from 2 to 5 bases, contain several motifs that have been previously discovered as associating highly with antisense activity, and have thermodynamic properties consistent with previous work associating thermodynamic properties of sequences with their antisense activity. Statistical analysis revealed no correlation between a motif's position within an antisense sequence and that sequences antisense activity. Also, many significant motifs existed as subwords of other significant motifs. Support vector regression experiments indicated that the feature set of significant motifs increased correlation compared to all possible motifs as well as several subsets of the significant motifs. The thermodynamic properties of the significantly associated motifs support existing data correlating the thermodynamic properties of the antisense oligonucleotide with antisense efficiency, reinforcing our hypothesis that antisense suppression is strongly associated with probe/target thermodynamics, as there are no enzymatic mediators to speed the process along like the RNA Induced Silencing Complex (RISC) in RNAi. The independence of motif position and antisense activity also allows us to bypass consideration of this feature in the modelling process, promoting model efficiency and reducing the chance of overfitting when predicting antisense activity. The increase in SVR correlation with significant features compared to nearest-neighbour features indicates that thermodynamics alone is likely not the only factor in determining antisense efficiency.

Risk Analysis Related to Quality Management Principles

NASA Astrophysics Data System (ADS)

Vykydal, David; Halfarová, Petra; Nenadál, Jaroslav; Plura, Jiří; Hekelová, Edita

2012-12-01

Efficient and effective implementation of quality management principles asks for a responsible approach from top managers' perspectives. A study of the current state of affairs in Czech organizations discovers a lot of shortcomings in this field that can be changed to vary managerial risks. The article identifies and analyses some of them and gives short guidance for appropriate treatment. Text of the article reflects the authors' experience as well as knowledge obtained from the systematic analysis of industrial companies' environments.

Discovery of Planetary Systems With SIM

NASA Technical Reports Server (NTRS)

Marcy, Geoffrey W.; Butler, Paul R.; Frink, Sabine; Fischer, Debra; Oppenheimer, Ben; Monet, David G.; Quirrenbach, Andreas; Scargle, Jeffrey D.

2004-01-01

We are witnessing the birth of a new observational science: the discovery and characterization of extrasolar planetary systems. In the past five years, over 70 extrasolar planets have been discovered by precision Doppler surveys, most by members of this SIM team. We are using the data base of information gleaned from our Doppler survey to choose the best targets for a new SIN planet search. In the same way that our Doppler database now serves SIM, our team will return a reconnaissance database to focus Terrestrial Planet Finder (TPF) into a more productive, efficient mission.

CARIBIAM: constrained Association Rules using Interactive Biological IncrementAl Mining.

PubMed

Rahal, Imad; Rahhal, Riad; Wang, Baoying; Perrizo, William

2008-01-01

This paper analyses annotated genome data by applying a very central data-mining technique known as Association Rule Mining (ARM) with the aim of discovering rules and hypotheses capable of yielding deeper insights into this type of data. In the literature, ARM has been noted for producing an overwhelming number of rules. This work proposes a new technique capable of using domain knowledge in the form of queries in order to efficiently mine only the subset of the associations that are of interest to investigators in an incremental and interactive manner.

Tools for identifying gelator scaffolds and solvents.

PubMed

Zurcher, Danielle M; McNeil, Anne J

2015-03-06

Small molecule gelators are serendipitously discovered more often than they are designed. As a consequence, it has been challenging to develop applications based on the limited set of known materials. This synopsis highlights recent strategies to streamline the process of gelator discovery, with a focus on the role of unidirectional intermolecular interactions and solvation. We present these strategies as a series of tools that can be employed to help identify gelator scaffolds and solvents for gel formation. Overall, we suggest that this guided approach is more efficient than random derivatization and screening.

A Metadata based Knowledge Discovery Methodology for Seeding Translational Research.

PubMed

Kothari, Cartik R; Payne, Philip R O

2015-01-01

In this paper, we present a semantic, metadata based knowledge discovery methodology for identifying teams of researchers from diverse backgrounds who can collaborate on interdisciplinary research projects: projects in areas that have been identified as high-impact areas at The Ohio State University. This methodology involves the semantic annotation of keywords and the postulation of semantic metrics to improve the efficiency of the path exploration algorithm as well as to rank the results. Results indicate that our methodology can discover groups of experts from diverse areas who can collaborate on translational research projects.

Operating systems and network protocols for wireless sensor networks.

PubMed

Dutta, Prabal; Dunkels, Adam

2012-01-13

Sensor network protocols exist to satisfy the communication needs of diverse applications, including data collection, event detection, target tracking and control. Network protocols to enable these services are constrained by the extreme resource scarcity of sensor nodes-including energy, computing, communications and storage-which must be carefully managed and multiplexed by the operating system. These challenges have led to new protocols and operating systems that are efficient in their energy consumption, careful in their computational needs and miserly in their memory footprints, all while discovering neighbours, forming networks, delivering data and correcting failures.

Global copy number profiling of cancer genomes | Office of Cancer Genomics

Cancer.gov

In this article, we introduce a robust and efficient strategy for deriving global and allele-specific copy number alternations (CNA) from cancer whole exome sequencing data based on Log R ratios and B-allele frequencies. Applying the approach to the analysis of over 200 skin cancer samples, we demonstrate its utility for discovering distinct CNA events and for deriving ancillary information such as tumor purity. Availability and implementation: https://github.com/xfwang/CLOSE CONTACT: xuefeng.wang@stonybrook.edu or michael.krauthammer@yale.edu. (Publication Abstract)

LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Gas-dynamic effects in the interaction of a motionless optical pulsating discharge with gas

NASA Astrophysics Data System (ADS)

Tishchenko, V. N.; Grachev, G. N.; Pavlov, A. A.; Smirnov, A. L.; Pavlov, A. A.; Golubev, M. P.

2008-01-01

The effect of energy removal from the combustion zone of a motionless optical pulsating discharge in the horizontal direction along the axis of a repetitively pulsed laser beam producing the discharge is discovered. The directivity diagram of a hot gas flow is formed during the action of hundreds of pulses. The effect is observed for short pulse durations, when the discharge efficiently generates shock waves. For long pulse durations, the heated gas propagates upward, as in a thermal source.

Proton Conductivity in Phosphoric Acid: The Role of Quantum Effects

DOE PAGES

Heres, M.; Wang, Y.; Griffin, P. J.; ...

2016-10-07

Phosphoric acid has one of the highest intrinsic proton conductivities of any known liquids, and the mechanism of this exceptional conductivity remains a puzzle. In our detailed experimental studies we discovered a strong isotope effect in the conductivity of phosphoric acids caused by (i) a strong isotope shift of the glass transition temperature and (ii) a significant reduction of the energy barrier by zero-point quantum fluctuations. Our results suggest that the high conductivity in phosphoric acids is caused by a very efficient proton transfer mechanism, which is strongly assisted by quantum effects.

Toeplitz Inverse Covariance-Based Clustering of Multivariate Time Series Data

PubMed Central

Hallac, David; Vare, Sagar; Boyd, Stephen; Leskovec, Jure

2018-01-01

Subsequence clustering of multivariate time series is a useful tool for discovering repeated patterns in temporal data. Once these patterns have been discovered, seemingly complicated datasets can be interpreted as a temporal sequence of only a small number of states, or clusters. For example, raw sensor data from a fitness-tracking application can be expressed as a timeline of a select few actions (i.e., walking, sitting, running). However, discovering these patterns is challenging because it requires simultaneous segmentation and clustering of the time series. Furthermore, interpreting the resulting clusters is difficult, especially when the data is high-dimensional. Here we propose a new method of model-based clustering, which we call Toeplitz Inverse Covariance-based Clustering (TICC). Each cluster in the TICC method is defined by a correlation network, or Markov random field (MRF), characterizing the interdependencies between different observations in a typical subsequence of that cluster. Based on this graphical representation, TICC simultaneously segments and clusters the time series data. We solve the TICC problem through alternating minimization, using a variation of the expectation maximization (EM) algorithm. We derive closed-form solutions to efficiently solve the two resulting subproblems in a scalable way, through dynamic programming and the alternating direction method of multipliers (ADMM), respectively. We validate our approach by comparing TICC to several state-of-the-art baselines in a series of synthetic experiments, and we then demonstrate on an automobile sensor dataset how TICC can be used to learn interpretable clusters in real-world scenarios. PMID:29770257

TMAP: A NEO follow-up program utilizing undergraduate observers

NASA Astrophysics Data System (ADS)

Ramirez, C.; Deaver, D.; Martinez, R.; Foster, J.; Kuang, L.; Ates, A.; Anderson, M.; Mijac, M.; Gillam, S.; Hicks, M. D.

2000-10-01

In the spring of 2000 we began TMAP (Table Mountain Astrometry Project), a program designed to provide timely astrometric followup of newly discovered near-Earth asteroids. Relying on undergraduate observers from the local California State Universities, we have to date been involved with the over 50 NEO and new comet discoveries. This is a significant fraction of all near-Earth asteroids discovered over the time period. All observations are performed at JPL's Table Mountain Facility near Wrightwood California using the 0.6-meter telescope equipped with a Photometrics LN cooled 1k CCD mounted at the cassegrain focus. With this system we can routinely detect objects to R=20.5. We have typically scheduled two runs per month on weekends bracketing the new moon. The student observers man the telescope are trained to select and obtain R-band images of candidates from the Minor Planet Center's NEO Confirmation Page (http://cfa-www.harvard.edu/cfa/ps/NEO/TheNEOPage.html). The astrometry is then reduced and submitted to the Minor Planet Center the following day. TMAP has proven to be an efficient way both to obtain much needed astrometric measurements of newly discovered small bodies as well as to involve undergraduate researchers in planetary research. The limiting magnitudes provided by the 0.6-meter partially fills the gap between the extremely helpful and dedicated amateur astromitrists and the followup that the NEO detection programs do themselves. This work is supported by NASA.

Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods.

PubMed

Lloyd, Amanda J; Favé, Gaëlle; Beckmann, Manfred; Lin, Wanchang; Tailliart, Kathleen; Xie, Long; Mathers, John C; Draper, John

2011-10-01

The lack of robust biological markers of dietary exposure hinders the quantitative understanding of causal relations between diet and health. We aimed to develop an efficient procedure to discover metabolites in urine that may have future potential as biomarkers of acute exposure to foods of high public health importance. Twenty-four participants were provided with a test breakfast in which the cereal component of a standardized breakfast was replaced by 1 of 4 foods of high public health importance; 1.5-, 3-, and 4.5-h postprandial urine samples were collected. Flow infusion electrospray-ionization mass spectrometry followed by supervised multivariate data analysis was used to discover signals resulting from consumption of each test food. Fasted-state urine samples provided a universal comparator for food biomarker lead discovery in postprandial urine. The filtering of data features associated with consumption of the common components of the standardized breakfast improved discrimination models and readily identified metabolites that showed consumption of specific test foods. A combination of trimethylamine-N-oxide and 1-methylhistidine was associated with salmon consumption. Novel ascorbate derivatives were discovered in urine after consumption of either broccoli or raspberries. Sulphonated caffeic acid and sulphonated methyl-epicatechin concentrations increased dramatically after consumption of raspberries. This biomarker lead discovery strategy can identify urinary metabolites associated with acute exposure to individual foods. Future studies are required to validate the specificity and utility of potential biomarkers in an epidemiologic context.

High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites

PubMed Central

Gilbert, Daniel F.; Islam, Robiul; Lynagh, Timothy; Lynch, Joseph W.; Webb, Timothy I.

2009-01-01

The inhibitory glycine receptor (GlyR) is a member of the Cys-loop receptor family that mediates inhibitory neurotransmission in the central nervous system. These receptors are emerging as potential drug targets for inflammatory pain, immunomodulation, spasticity and epilepsy. Antagonists that specifically inhibit particular GlyR isoforms are also required as pharmacological probes for elucidating the roles of particular GlyR isoforms in health and disease. Although a substantial number of both positive and negative GlyR modulators have been identified, very few of these are specific for the GlyR over other receptor types. Thus, the potential of known compounds as either therapeutic leads or pharmacological probes is limited. It is therefore surprising that there have been few published studies describing attempts to discover novel GlyR isoform-specific modulators. The first aim of this review is to consider various methods for efficiently screening compounds against these receptors. We conclude that an anion sensitive yellow fluorescent protein is optimal for primary screening and that automated electrophysiology of cells stably expressing GlyRs is useful for confirming hits and quantitating the actions of identified compounds. The second aim of this review is to demonstrate how these techniques are used in our laboratory for the purpose of both discovering novel GlyR-active compounds and characterizing their binding sites. We also describe a reliable, cost effective method for transfecting HEK293 cells in single wells of a 384-well plate using nanogram quantities of plasmid DNA. PMID:19949449

Efficient, flexible and mechanically robust perovskite solar cells on inverted nanocone plastic substrates.

PubMed

Tavakoli, Mohammad Mahdi; Lin, Qingfeng; Leung, Siu-Fung; Lui, Ga Ching; Lu, Hao; Li, Liang; Xiang, Bin; Fan, Zhiyong

2016-02-21

Utilization of nanostructures on photovoltaic devices can significantly improve the device energy conversion efficiency by enhancing the device light harvesting capability as well as carrier collection efficiency. However, improvements in device mechanical robustness and reliability, particularly for flexible devices, have rarely been reported with in-depth understanding. In this work, we fabricated efficient, flexible and mechanically robust organometallic perovskite solar cells on plastic substrates with inverted nanocone (i-cone) structures. Compared with the reference cell that was fabricated on a flat substrate, it was shown that the device power conversion efficiency could be improved by 37%, and reached up to 11.29% on i-cone substrates. More interestingly, it was discovered that the performance of an i-cone device remained more than 90% of the initial value even after 200 mechanical bending cycles, which is remarkably better than for the flat reference device, which degraded down to only 60% in the same test. Our experiments, coupled with mechanical simulation, demonstrated that a nanostructured template can greatly help in relaxing stress and strain upon device bending, which suppresses crack nucleation in different layers of a perovskite solar cell. This essentially leads to much improved device reliability and robustness and will have significant impact on practical applications.

Division of methods for counting helminths' eggs and the problem of efficiency of these methods.

PubMed

Jaromin-Gleń, Katarzyna; Kłapeć, Teresa; Łagód, Grzegorz; Karamon, Jacek; Malicki, Jacek; Skowrońska, Agata; Bieganowski, Andrzej

2017-03-21

From the sanitary and epidemiological aspects, information concerning the developmental forms of intestinal parasites, especially the eggs of helminths present in our environment in: water, soil, sandpits, sewage sludge, crops watered with wastewater are very important. The methods described in the relevant literature may be classified in various ways, primarily according to the methodology of the preparation of samples from environmental matrices prepared for analysis, and the sole methods of counting and chambers/instruments used for this purpose. In addition, there is a possibility to perform the classification of the research methods analyzed from the aspect of the method and time of identification of the individuals counted, or the necessity for staining them. Standard methods for identification of helminths' eggs from environmental matrices are usually characterized by low efficiency, i.e. from 30% to approximately 80%. The efficiency of the method applied may be measured in a dual way, either by using the method of internal standard or the 'Split/Spike' method. While measuring simultaneously in an examined object the efficiency of the method and the number of eggs, the 'actual' number of eggs may be calculated by multiplying the obtained value of the discovered eggs of helminths by inverse efficiency.

Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity.

PubMed

Xu, Yun-Yun; Li, Si-Ning; Yu, Gao-Jian; Hu, Qing-Hua; Li, Huan-Qiu

2013-10-01

Two new series of new compounds containing a 6-amino-substituted group or 6-acrylamide-substituted group linked to a 4-anilinoquinazoline nucleus have been discovered as potential EGFR inhibitors. These compounds proved efficient effects on antiproliferative activity and EGFR-TK inhibitory activity. Especially, N(6)-((5-bromothiophen-2-yl)methyl)-N(4)-(3-chlorophenyl)quinazoline-4,6-diamine (5e), showed the most potent inhibitory activity (IC50=3.11μM for Hep G2, IC50=0.82μM for A549). The EGFR molecular docking model suggested that the new compound is nicely bound to the region of EGFR, and cell morphology by Hoechst stain experiment suggested that these compounds efficiently induced apoptosis of A549 cells. Copyright © 2013 Elsevier Ltd. All rights reserved.

76 FR 6927 - Radio Experimentation and Market Trials Under Part 5 of the Commission's Rules and Streamlining...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

...In this document, the Commission seeks to promote innovation and efficiency in spectrum use in the Experimental Radio Service (ERS). For many years, the ERS has provided fertile ground for testing innovative ideas that have led to new services and new devices for all sectors of the economy. The Commission proposes to leverage the power of experimental radio licensing to accelerate the rate at which these ideas transform from prototypes to consumer devices and services. Its goal is to inspire researchers to dream, discover and deliver the innovations that push the boundaries of the broadband ecosystem. The resulting advancements in devices and services available to the American public and greater spectrum efficiency over the long term will promote economic growth, global competitiveness, and a better way of life for all Americans.

Development of Highly Fluorescent Materials Based on Thiophenylimidazole Dyes

NASA Technical Reports Server (NTRS)

Santos, Javier; Bu, Xiu R.; Mintz, Eric A.; Meador, Michael A. (Technical Monitor)

2000-01-01

Organic fluorescent materials are expected to find many potential applications in optical devices and photo-functionalized materials. Although many investigations have been focused on heterocyclic compounds such as coumarins, bipyridines, rhodamines, and pyrrole derivatives, little is known for fluorescent imidazole materials. We discovered that one particular class of imidazole derivatives is highly fluorescent. A series of monomeric and polymeric based fluorescent dyes were prepared containing a thiophene unit at the second position of the imidazole ring. Dependence of fluorescence efficiency on parameters such as solvent polarity and substituent groups has been investigated. It was found that a formyl group at the 2-position of the thiophene ring dramatically enhance fluorescence properties. Ion recognition probes indicated their potential as sensor materials. These fluorophores have flexibility for introduction of versatile substituent groups that could improve the fluorescence efficiency and sensor properties.

The potential risk of communication media in conveying critical information in the aircraft maintenance organisation: a case study

NASA Astrophysics Data System (ADS)

Shukri, S. Ahmad; Millar, R. M.; Gratton, G.; Garner, M.

2016-10-01

In the world of aircraft maintenance organisation, verbal and written communication plays a pivotal role in transferring critical information in relation to aircraft safety and efficiency. The communication media used to convey the critical information between departments at an aircraft maintenance organisation have potential risk in misunderstanding of the information. In this study, technical and non-technical personnel from five different departments at an aircraft maintenance organisation were interviewed on the communication media they normally utilised to communicate six different work procedures that are closely related to aircraft safety and efficiency. This is to discover which communication media pose higher risk in misunderstanding critical information. The findings reveal that written communication pose higher risk of misinterpretation compared with verbal communication when conveying critical information between departments.

[Cleanliness in the operating room].

PubMed

Suzuki, Toshiyasu

2010-05-01

With regard to recent findings in the cleanliness of the operating room, concerning handwashing and performing operations, the traditional method of excessive scrubbing using a brush is not effective, and handwashing using only an alcohol-containing antiseptic hand rub (rubbing method) has become common practice. Use of a brush has already been abolished in some medical institutions. In addition, sterilized water used for handwashing when performing operations has no scientific basis and use of tap water is considered sufficient. Furthermore, the concept of operating room zoning has also undergone a dramatic change. It was discovered that a layout focusing on work efficiency is more desirable than the one that follows an excessively rigid zoning pattern. One-footwear System not requiring change of shoes also has various advantages in improving the efficiency of the operation room, and this is thought to become commonplace in the future.

Privacy Preserving Association Rule Mining Revisited: Privacy Enhancement and Resources Efficiency

NASA Astrophysics Data System (ADS)

Mohaisen, Abedelaziz; Jho, Nam-Su; Hong, Dowon; Nyang, Daehun

Privacy preserving association rule mining algorithms have been designed for discovering the relations between variables in data while maintaining the data privacy. In this article we revise one of the recently introduced schemes for association rule mining using fake transactions (FS). In particular, our analysis shows that the FS scheme has exhaustive storage and high computation requirements for guaranteeing a reasonable level of privacy. We introduce a realistic definition of privacy that benefits from the average case privacy and motivates the study of a weakness in the structure of FS by fake transactions filtering. In order to overcome this problem, we improve the FS scheme by presenting a hybrid scheme that considers both privacy and resources as two concurrent guidelines. Analytical and empirical results show the efficiency and applicability of our proposed scheme.

Identification of bioconversion quantitative trait loci in the interspecific cross Sorghum bicolor × Sorghum propinquum.

PubMed

Vandenbrink, Joshua P; Goff, Valorie; Jin, Huizhe; Kong, Wenqian; Paterson, Andrew H; Feltus, F Alex

2013-09-01

For lignocellulosic bioenergy to be economically viable, genetic improvements must be made in feedstock quality including both biomass total yield and conversion efficiency. Toward this goal, multiple studies have considered candidate genes and discovered quantitative trait loci (QTL) associated with total biomass accumulation and/or grain production in bioenergy grass species including maize and sorghum. However, very little research has been focused on genes associated with increased biomass conversion efficiency. In this study, Trichoderma viride fungal cellulase hydrolysis activity was measured for lignocellulosic biomass (leaf and stem tissue) obtained from individuals in a F5 recombinant inbred Sorghum bicolor × Sorghum propinquum mapping population. A total of 49 QTLs (20 leaf, 29 stem) were associated with enzymatic conversion efficiency. Interestingly, six high-density QTL regions were identified in which four or more QTLs overlapped. In addition to enzymatic conversion efficiency QTLs, two QTLs were identified for biomass crystallinity index, a trait which has been shown to be inversely correlated with conversion efficiency in bioenergy grasses. The identification of these QTLs provides an important step toward identifying specific genes relevant to increasing conversion efficiency of bioenergy feedstocks. DNA markers linked to these QTLs could be useful in marker-assisted breeding programs aimed at increasing overall bioenergy yields concomitant with selection of high total biomass genotypes.

Highly Efficient Interception and Precipitation of Uranium(VI) from Aqueous Solution by Iron-Electrocoagulation Combined with Cooperative Chelation by Organic Ligands.

PubMed

Li, Peng; Zhun, Bao; Wang, Xuegang; Liao, PingPing; Wang, Guanghui; Wang, Lizhang; Guo, Yadan; Zhang, Weimin

2017-12-19

A new strategy combining iron-electrocoagulation and organic ligands (OGLs) cooperative chelation was proposed to screen and precipitate low concentrations (0-18.52 μmol/L) of uranium contaminant in aqueous solution. We hypothesized that OGLs with amino, hydroxyl, and carboxyl groups hydrophobically/hydrophilically would realize precuring of uranyl ion at pH < 3.0, and the following iron-electrocoagulation would achieve faster and more efficient uranium precipitation. Experimentally, the strategy demonstrated highly efficient uranium(VI) precipitation efficiency, especially with hydrophilic macromolecular OGLs. The uranium removal efficiency at optimized experimental condition reached 99.65%. The decrease of zeta potential and the lattice enwrapping between U-OGLs chelates and flocculation precursor were ascribed to the enhanced uranium precipitation activity. Uranium was precipitated as oxides of U(VI) or higher valences that were easily captured in aggregated micelles under low operation current potential. The actual uranium tailing wastewater was treated, and a satisfied uranium removal efficiency of 99.02% was discovered. After elution of the precipitated flocs, a concentrated uranium solution (up to 106.52 μmol/L) with very few other metallic impurities was obtained. Therefore, the proposed strategy could remove uranium and concentrate it concurrently. This work could provide new insights into the purification and recovery of uranium from aqueous solutions in a cost-effective and environmentally friendly process.

Spatial Data Infrastructures (SDIs): Improving the Scientific Environmental Data Management and Visualization with ArcGIS Platform

NASA Astrophysics Data System (ADS)

Shrestha, S. R.; Hogeweg, M.; Rose, B.; Turner, A.

2017-12-01

The requirement for quality, authoritatively sourced data can often be challenging when working with scientific data. In addition, the lack of standard mechanism to discover, access, and use such data can be cumbersome. This results in slow research, poor dissemination and missed opportunities for research to positively impact policy and knowledge. There is widespread recognition that authoritative datasets are maintained by multiple organizations following various standards, and addressing these challenges will involve multiple stakeholders as well. The bottom line is that organizations need a mechanism to efficiently create, share, catalog, and discover data, and the ability to apply these to create an authoritative information products and applications is powerful and provides value. In real-world applications, individual organizations develop, modify, finalize, and support foundational data for distributed users across the system and thus require an efficient method of data management. For this, the SDI (Spatial Data Infrastructure) framework can be applied for GIS users to facilitate efficient and powerful decision making based on strong visualization and analytics. Working with research institutions, governments, and organizations across the world, we have developed a Hub framework for data and analysis sharing that is driven by outcome-centric goals which apply common methodologies and standards. SDI are an operational capability that should be equitably accessible to policy-makers, analysts, departments and public communities. These SDI need to align with operational workflows and support social communications and collaboration. The Hub framework integrates data across agencies, projects and organizations to support interoperability and drive coordination. We will present and share how Esri has been supporting the development of local, state, and national SDIs for many years and show some use cases for applications of planetary SDI. We will also share what makes an SDI successful, how organizations have used the ArcGIS platform to quickly stand up key SDI products and applications, and describe some typical SDI scenarios.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hardin, M; Harrison, A; Lockamy, V

Purpose: Desire to improve efficiency and throughput inspired a review of our physics chart check procedures. Departmental policy mandates plan checks pre-treatment, after first treatment and weekly every 3–5 days. This study examined the effectiveness of the “after first” check with respect to improving patient safety and clinical efficiency. Type and frequency of variations discovered during this redundant secondary review was examined over seven months. Methods: A community spreadsheet was created to record variations in care discovered during chart review following the first fraction of treatment and before the second fraction (each plan reviewed prior to treatment). Entries were recordedmore » from August 2014 through February 2015, amounting to 43 recorded variations out of 906 reviewed charts. The variations were divided into categories and frequencies were assessed month-to-month. Results: Analysis of recorded variations indicates an overall variation rate of 4.7%. The initial rate was 13.5%; months 2–7 average 3.7%. The majority of variations related to discrepancies in documentation at 46.5%, followed by prescription, plan deficiency, and dose tracking related variations at 25.5%, 12.8%, and 12.8%, respectively. Minor variations (negligible consequence on patient treatment) outweighed major variations 3 to 1. Conclusion: This work indicates that this redundant secondary check is effective. The first month spike in rates could be due to the Hawthorne/observer effect, but the consistent 4% variation rate suggests the need for periodical re-training on variations noted as frequent to improve awareness and quality of the initial chart review process, which may lead to improved treatment quality, patient safety and increased clinical efficiency. Utilizing these results, a continuous quality improvement process following Deming’s Plan-Do-Study-Act (PDSA) methodology was generated. The first iteration of this PDSA was adding a specific dose tracking checklist item in the pre-treatment plan check assessment; the ramification of which will be assessed in future data.« less

Energy Efficient Cluster Based Scheduling Scheme for Wireless Sensor Networks

PubMed Central

Srie Vidhya Janani, E.; Ganesh Kumar, P.

2015-01-01

The energy utilization of sensor nodes in large scale wireless sensor network points out the crucial need for scalable and energy efficient clustering protocols. Since sensor nodes usually operate on batteries, the maximum utility of network is greatly dependent on ideal usage of energy leftover in these sensor nodes. In this paper, we propose an Energy Efficient Cluster Based Scheduling Scheme for wireless sensor networks that balances the sensor network lifetime and energy efficiency. In the first phase of our proposed scheme, cluster topology is discovered and cluster head is chosen based on remaining energy level. The cluster head monitors the network energy threshold value to identify the energy drain rate of all its cluster members. In the second phase, scheduling algorithm is presented to allocate time slots to cluster member data packets. Here congestion occurrence is totally avoided. In the third phase, energy consumption model is proposed to maintain maximum residual energy level across the network. Moreover, we also propose a new packet format which is given to all cluster member nodes. The simulation results prove that the proposed scheme greatly contributes to maximum network lifetime, high energy, reduced overhead, and maximum delivery ratio. PMID:26495417

Sequence determinants of improved CRISPR sgRNA design.

PubMed

Xu, Han; Xiao, Tengfei; Chen, Chen-Hao; Li, Wei; Meyer, Clifford A; Wu, Qiu; Wu, Di; Cong, Le; Zhang, Feng; Liu, Jun S; Brown, Myles; Liu, X Shirley

2015-08-01

The CRISPR/Cas9 system has revolutionized mammalian somatic cell genetics. Genome-wide functional screens using CRISPR/Cas9-mediated knockout or dCas9 fusion-mediated inhibition/activation (CRISPRi/a) are powerful techniques for discovering phenotype-associated gene function. We systematically assessed the DNA sequence features that contribute to single guide RNA (sgRNA) efficiency in CRISPR-based screens. Leveraging the information from multiple designs, we derived a new sequence model for predicting sgRNA efficiency in CRISPR/Cas9 knockout experiments. Our model confirmed known features and suggested new features including a preference for cytosine at the cleavage site. The model was experimentally validated for sgRNA-mediated mutation rate and protein knockout efficiency. Tested on independent data sets, the model achieved significant results in both positive and negative selection conditions and outperformed existing models. We also found that the sequence preference for CRISPRi/a is substantially different from that for CRISPR/Cas9 knockout and propose a new model for predicting sgRNA efficiency in CRISPRi/a experiments. These results facilitate the genome-wide design of improved sgRNA for both knockout and CRISPRi/a studies. © 2015 Xu et al.; Published by Cold Spring Harbor Laboratory Press.

Neuropsychiatric SLE: from animal model to human.

PubMed

Pikman, R; Kivity, S; Levy, Y; Arango, M-T; Chapman, J; Yonath, H; Shoenfeld, Y; Gofrit, S G

2017-04-01

Animal models are a key element in disease research and treatment. In the field of neuropsychiatric lupus research, inbred, transgenic and disease-induced mice provide an opportunity to study the pathogenic routes of this multifactorial illness. In addition to achieving a better understanding of the immune mechanisms underlying the disease onset, supplementary metabolic and endocrine influences have been discovered and investigated. The ever-expanding knowledge about the pathologic events that occur at disease inception enables us to explore new drugs and therapeutic approaches further and to test them using the same animal models. Discovery of the molecular targets that constitute the pathogenic basis of the disease along with scientific advancements allow us to target these molecules with monoclonal antibodies and other specific approaches directly. This novel therapy, termed "targeted biological medication" is a promising endeavor towards producing drugs that are more effective and less toxic. Further work to discover additional molecular targets in lupus' pathogenic mechanism and to produce drugs that neutralize their activity is needed to provide patients with safe and efficient methods of controlling and treating the disease.

VLT/X-shooter Spectroscopy of a dusty planetary nebula discovered with Spitzer/IRS

NASA Astrophysics Data System (ADS)

Oliveira, I.; Overzier, R. A.; Pontoppidan, K. M.; van Dishoeck, E. F.; Spezzi, L.

2011-02-01

As part of a mid-infrared spectroscopic survey of young stars with the Spitzer Space Telescope, an unclassified red emission line object was discovered. Based on its high ionization state indicated by the Spitzer spectrum, this object could either be a dusty supernova remnant (SNR) or a planetary nebula (PN). In this research note, the object is classified and the available spectroscopic data are presented to the community for further analysis. UV/optical/NIR spectra were obtained during the science verification run of the VLT/X-shooter. A large number of emission lines are identified allowing the determination of the nature of this object. The presence of strong, narrow (Δv ~8 - 74 km s-1) emission lines, combined with very low line ratios of, e.g., [N ii]/Hα and [S ii]/Hα show that the object is a PN that lies at an undetermined distance behind the Serpens Molecular Cloud. This illustrates the potential of X-shooter as an efficient tool for constraining the nature of faint sources with unknown spectral properties or colors.

High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers

PubMed Central

You, Xinxin; Bian, Chao; Chen, Shixi; Lv, Zhao; Qiu, Limei; Shi, Qiong

2017-01-01

Widespread existence of antimicrobial peptides (AMPs) has been reported in various animals with comprehensive biological activities, which is consistent with the important roles of AMPs as the first line of host defense system. However, no big-data-based analysis on AMPs from any fish species is available. In this study, we identified 507 AMP transcripts on the basis of our previously reported genomes and transcriptomes of two representative amphibious mudskippers, Boleophthalmus pectinirostris (BP) and Periophthalmus magnuspinnatus (PM). The former is predominantly aquatic with less time out of water, while the latter is primarily terrestrial with extended periods of time on land. Within these identified AMPs, 449 sequences are novel; 15 were reported in BP previously; 48 are identically overlapped between BP and PM; 94 were validated by mass spectrometry. Moreover, most AMPs presented differential tissue transcription patterns in the two mudskippers. Interestingly, we discovered two AMPs, hemoglobin β1 and amylin, with high inhibitions on Micrococcus luteus. In conclusion, our high-throughput screening strategy based on genomic and transcriptomic data opens an efficient pathway to discover new antimicrobial peptides for ongoing development of marine drugs. PMID:29165344

Automated Classification of Asteroids into Families at Work

NASA Astrophysics Data System (ADS)

Knežević, Zoran; Milani, Andrea; Cellino, Alberto; Novaković, Bojan; Spoto, Federica; Paolicchi, Paolo

2014-07-01

We have recently proposed a new approach to the asteroid family classification by combining the classical HCM method with an automated procedure to add newly discovered members to existing families. This approach is specifically intended to cope with ever increasing asteroid data sets, and consists of several steps to segment the problem and handle the very large amount of data in an efficient and accurate manner. We briefly present all these steps and show the results from three subsequent updates making use of only the automated step of attributing the newly numbered asteroids to the known families. We describe the changes of the individual families membership, as well as the evolution of the classification due to the newly added intersections between the families, resolved candidate family mergers, and emergence of the new candidates for the mergers. We thus demonstrate how by the new approach the asteroid family classification becomes stable in general terms (converging towards a permanent list of confirmed families), and in the same time evolving in details (to account for the newly discovered asteroids) at each update.

A method for exploring implicit concept relatedness in biomedical knowledge network.

PubMed

Bai, Tian; Gong, Leiguang; Wang, Ye; Wang, Yan; Kulikowski, Casimir A; Huang, Lan

2016-07-19

Biomedical information and knowledge, structural and non-structural, stored in different repositories can be semantically connected to form a hybrid knowledge network. How to compute relatedness between concepts and discover valuable but implicit information or knowledge from it effectively and efficiently is of paramount importance for precision medicine, and a major challenge facing the biomedical research community. In this study, a hybrid biomedical knowledge network is constructed by linking concepts across multiple biomedical ontologies as well as non-structural biomedical knowledge sources. To discover implicit relatedness between concepts in ontologies for which potentially valuable relationships (implicit knowledge) may exist, we developed a Multi-Ontology Relatedness Model (MORM) within the knowledge network, for which a relatedness network (RN) is defined and computed across multiple ontologies using a formal inference mechanism of set-theoretic operations. Semantic constraints are designed and implemented to prune the search space of the relatedness network. Experiments to test examples of several biomedical applications have been carried out, and the evaluation of the results showed an encouraging potential of the proposed approach to biomedical knowledge discovery.

The transparency trap.

PubMed

Bernstein, Ethan

2014-10-01

To promote accountability, productivity, and shared learning, many organizations create open work environments and gather reams of data on how individuals spend their time. A few years ago, HBS professor Ethan Bernstein set out to find empirical evidence that such approaches improve organizational performance. What he discovered is that this kind of transparency often has an unintended consequence: It can leave employees feeling vulnerable and exposed. When that happens, they conceal any conduct that deviates from the norm so that they won't have to explain it. Unrehearsed, experimental behaviors sometimes stop altogether. But Bernstein also discovered organizations that had established zones of privacy within open environments by setting four types of boundaries: around teams, between feedback and evaluation, between decision rights and improvement rights, and around periods of experimentation. Moreover, across several studies, the companies that had done all this were the ones that consistently got the most creative, efficient, and thoughtful work from their employees. Bernstein's conclusion? By balancing transparency and privacy, organizations can capture the benefits of both, and encourage just the right amount of "positive deviance" needed to increase innovation and productivity.

Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect-specific flaviviruses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Firth, Andrew E., E-mail: a.firth@ucc.i; Blitvich, Bradley J., E-mail: blitvich@iastate.ed; Wills, Norma M., E-mail: nwills@genetics.utah.ed

2010-03-30

Flaviviruses have a positive-sense, single-stranded RNA genome of approx11 kb, encoding a large polyprotein that is cleaved to produce approx10 mature proteins. Cell fusing agent virus, Kamiti River virus, Culex flavivirus and several recently discovered flaviviruses have no known vertebrate host and apparently infect only insects. We present compelling bioinformatic evidence for a 253-295 codon overlapping gene (designated fifo) conserved throughout these insect-specific flaviviruses and immunofluorescent detection of its product. Fifo overlaps the NS2A/NS2B coding sequence in the - 1/+ 2 reading frame and is most likely expressed as a trans-frame fusion protein via ribosomal frameshifting at a conserved GGAUUUYmore » slippery heptanucleotide with 3'-adjacent RNA secondary structure (which stimulates efficient frameshifting in vitro). The discovery bears striking parallels to the recently discovered ribosomal frameshifting site in the NS2A coding sequence of the Japanese encephalitis serogroup of flaviviruses and suggests that programmed ribosomal frameshifting may be more widespread in flaviviruses than currently realized.« less

Bio-inspired silicon nanospikes fabricated by metal-assisted chemical etching for antibacterial surfaces

NASA Astrophysics Data System (ADS)

Hu, Huan; Siu, Vince S.; Gifford, Stacey M.; Kim, Sungcheol; Lu, Minhua; Meyer, Pablo; Stolovitzky, Gustavo A.

2017-12-01

The recently discovered bactericidal properties of nanostructures on wings of insects such as cicadas and dragonflies have inspired the development of similar nanostructured surfaces for antibacterial applications. Since most antibacterial applications require nanostructures covering a considerable amount of area, a practical fabrication method needs to be cost-effective and scalable. However, most reported nanofabrication methods require either expensive equipment or a high temperature process, limiting cost efficiency and scalability. Here, we report a simple, fast, low-cost, and scalable antibacterial surface nanofabrication methodology. Our method is based on metal-assisted chemical etching that only requires etching a single crystal silicon substrate in a mixture of silver nitrate and hydrofluoric acid for several minutes. We experimentally studied the effects of etching time on the morphology of the silicon nanospikes and the bactericidal properties of the resulting surface. We discovered that 6 minutes of etching results in a surface containing silicon nanospikes with optimal geometry. The bactericidal properties of the silicon nanospikes were supported by bacterial plating results, fluorescence images, and scanning electron microscopy images.

High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers.

PubMed

Yi, Yunhai; You, Xinxin; Bian, Chao; Chen, Shixi; Lv, Zhao; Qiu, Limei; Shi, Qiong

2017-11-22

Widespread existence of antimicrobial peptides (AMPs) has been reported in various animals with comprehensive biological activities, which is consistent with the important roles of AMPs as the first line of host defense system. However, no big-data-based analysis on AMPs from any fish species is available. In this study, we identified 507 AMP transcripts on the basis of our previously reported genomes and transcriptomes of two representative amphibious mudskippers, Boleophthalmus pectinirostris (BP) and Periophthalmus magnuspinnatus (PM). The former is predominantly aquatic with less time out of water, while the latter is primarily terrestrial with extended periods of time on land. Within these identified AMPs, 449 sequences are novel; 15 were reported in BP previously; 48 are identically overlapped between BP and PM; 94 were validated by mass spectrometry. Moreover, most AMPs presented differential tissue transcription patterns in the two mudskippers. Interestingly, we discovered two AMPs, hemoglobin β1 and amylin, with high inhibitions on Micrococcus luteus . In conclusion, our high-throughput screening strategy based on genomic and transcriptomic data opens an efficient pathway to discover new antimicrobial peptides for ongoing development of marine drugs.

The Infrared-Optical Telescope (IRT) of the Exist Observatory

NASA Technical Reports Server (NTRS)

Kutyrev, Alexander; Bloom, Joshua; Gehrels, Neil; Golisano, Craig; Gong, Quan; Grindlay, Jonathan; Moseley, Samuel; Woodgate, Bruce

2010-01-01

The IRT is a 1.1m visible and infrared passively cooled telescope, which can locate, identify and obtain spectra of GRB afterglows at redshifts up to z 20. It will also acquire optical-IR, imaging and spectroscopy of AGN and transients discovered by the EXIST (The Energetic X-ray Imaging Survey Telescope). The IRT imaging and spectroscopic capabilities cover a broad spectral range from 0.32.2m in four bands. The identical fields of view in the four instrument bands are each split in three subfields: imaging, objective prism slitless for the field and objective prism single object slit low resolution spectroscopy, and high resolution long slit on single object. This allows the instrument, to do simultaneous broadband photometry or spectroscopy of the same object over the full spectral range, thus greatly improving the efficiency of the observatory and its detection limits. A prompt follow up (within three minutes) of the transient discovered by the EXIST makes IRT a unique tool for detection and study of these events, which is particularly valuable at wavelengths unavailable to the ground based observatories.

IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening

PubMed Central

Tidten-Luksch, Naomi; Grimaldi, Raffaella; Torrie, Leah S.; Frearson, Julie A.; Hunter, William N.; Brenk, Ruth

2012-01-01

CDP-ME kinase (IspE) contributes to the non-mevalonate or deoxy-xylulose phosphate (DOXP) pathway for isoprenoid precursor biosynthesis found in many species of bacteria and apicomplexan parasites. IspE has been shown to be essential by genetic methods and since it is absent from humans it constitutes a promising target for antimicrobial drug development. Using in silico screening directed against the substrate binding site and in vitro high-throughput screening directed against both, the substrate and co-factor binding sites, non-substrate-like IspE inhibitors have been discovered and structure-activity relationships were derived. The best inhibitors in each series have high ligand efficiencies and favourable physico-chemical properties rendering them promising starting points for drug discovery. Putative binding modes of the ligands were suggested which are consistent with established structure-activity relationships. The applied screening methods were complementary in discovering hit compounds, and a comparison of both approaches highlights their strengths and weaknesses. It is noteworthy that compounds identified by virtual screening methods provided the controls for the biochemical screens. PMID:22563402

Quantitative Trait Loci (QTL)-Guided Metabolic Engineering of a Complex Trait.

PubMed

Maurer, Matthew J; Sutardja, Lawrence; Pinel, Dominic; Bauer, Stefan; Muehlbauer, Amanda L; Ames, Tyler D; Skerker, Jeffrey M; Arkin, Adam P

2017-03-17

Engineering complex phenotypes for industrial and synthetic biology applications is difficult and often confounds rational design. Bioethanol production from lignocellulosic feedstocks is a complex trait that requires multiple host systems to utilize, detoxify, and metabolize a mixture of sugars and inhibitors present in plant hydrolysates. Here, we demonstrate an integrated approach to discovering and optimizing host factors that impact fitness of Saccharomyces cerevisiae during fermentation of a Miscanthus x giganteus plant hydrolysate. We first used high-resolution Quantitative Trait Loci (QTL) mapping and systematic bulk Reciprocal Hemizygosity Analysis (bRHA) to discover 17 loci that differentiate hydrolysate tolerance between an industrially related (JAY291) and a laboratory (S288C) strain. We then used this data to identify a subset of favorable allelic loci that were most amenable for strain engineering. Guided by this "genetic blueprint", and using a dual-guide Cas9-based method to efficiently perform multikilobase locus replacements, we engineered an S288C-derived strain with superior hydrolysate tolerance than JAY291. Our methods should be generalizable to engineering any complex trait in S. cerevisiae, as well as other organisms.

DISCOVER-AQ

Atmospheric Science Data Center

2017-01-31

... Relevant Documents:  DISCOVER-AQ - Airborne Science Data for Atmospheric Composition DISCOVER-AQ - NASA Earth ... DISCOVER-AQ - Mission Highlight Featured Articles : Articles featuring DISCOVER-AQ data products SCAR-B ...

Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer.

PubMed

Murase, Ryuichi; Kawamura, Rumi; Singer, Eric; Pakdel, Arash; Sarma, Pranamee; Judkins, Jonathon; Elwakeel, Eiman; Dayal, Sonali; Martinez-Martinez, Esther; Amere, Mukkanti; Gujjar, Ramesh; Mahadevan, Anu; Desprez, Pierre-Yves; McAllister, Sean D

2014-10-01

The psychoactive cannabinoid Δ(9) -tetrahydrocannabinol (THC) and the non-psychoactive cannabinoid cannabidiol (CBD) can both reduce cancer progression, each through distinct anti-tumour pathways. Our goal was to discover a compound that could efficiently target both cannabinoid anti-tumour pathways. To measure breast cancer cell proliferation/viability and invasion, MTT and Boyden chamber assays were used. Modulation of reactive oxygen species (ROS) and apoptosis was measured using dichlorodihydrofluorescein and annexin/propidium iodide, respectively, in combination with cell flow cytometry. Changes in protein levels were evaluated using Western analysis. Orthotopic and i.v. mouse models of breast cancer metastasis were used to test the activity of cannabinoids in vivo. CBD reduced breast cancer metastasis in advanced stages of the disease as the direct result of down-regulating the transcriptional regulator Id1. However, this was associated with moderate increases in survival. We therefore screened for analogues that could co-target cannabinoid anti-tumour pathways (CBD- and THC-associated) and discovered the compound O-1663. This analogue inhibited Id1, produced a marked stimulation of ROS, up-regulated autophagy and induced apoptosis. Of all the compounds tested, it was the most potent at inhibiting breast cancer cell proliferation and invasion in culture and metastasis in vivo. O-1663 prolonged survival in advanced stages of breast cancer metastasis. Developing compounds that can simultaneously target multiple cannabinoid anti-tumour pathways efficiently may provide a novel approach for the treatment of patients with metastatic breast cancer. © 2014 The British Pharmacological Society.

Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer

PubMed Central

Murase, Ryuichi; Kawamura, Rumi; Singer, Eric; Pakdel, Arash; Sarma, Pranamee; Judkins, Jonathon; Elwakeel, Eiman; Dayal, Sonali; Martinez-Martinez, Esther; Amere, Mukkanti; Gujjar, Ramesh; Mahadevan, Anu; Desprez, Pierre-Yves; McAllister, Sean D

2014-01-01

Background and Purpose The psychoactive cannabinoid Δ9-tetrahydrocannabinol (THC) and the non-psychoactive cannabinoid cannabidiol (CBD) can both reduce cancer progression, each through distinct anti-tumour pathways. Our goal was to discover a compound that could efficiently target both cannabinoid anti-tumour pathways. Experimental Approach To measure breast cancer cell proliferation/viability and invasion, MTT and Boyden chamber assays were used. Modulation of reactive oxygen species (ROS) and apoptosis was measured using dichlorodihydrofluorescein and annexin/propidium iodide, respectively, in combination with cell flow cytometry. Changes in protein levels were evaluated using Western analysis. Orthotopic and i.v. mouse models of breast cancer metastasis were used to test the activity of cannabinoids in vivo. Key Results CBD reduced breast cancer metastasis in advanced stages of the disease as the direct result of down-regulating the transcriptional regulator Id1. However, this was associated with moderate increases in survival. We therefore screened for analogues that could co-target cannabinoid anti-tumour pathways (CBD- and THC-associated) and discovered the compound O-1663. This analogue inhibited Id1, produced a marked stimulation of ROS, up-regulated autophagy and induced apoptosis. Of all the compounds tested, it was the most potent at inhibiting breast cancer cell proliferation and invasion in culture and metastasis in vivo. Conclusions and Implications O-1663 prolonged survival in advanced stages of breast cancer metastasis. Developing compounds that can simultaneously target multiple cannabinoid anti-tumour pathways efficiently may provide a novel approach for the treatment of patients with metastatic breast cancer. PMID:24910342

Discovering discovery patterns with Predication-based Semantic Indexing.

PubMed

Cohen, Trevor; Widdows, Dominic; Schvaneveldt, Roger W; Davies, Peter; Rindflesch, Thomas C

2012-12-01

In this paper we utilize methods of hyperdimensional computing to mediate the identification of therapeutically useful connections for the purpose of literature-based discovery. Our approach, named Predication-based Semantic Indexing, is utilized to identify empirically sequences of relationships known as "discovery patterns", such as "drug x INHIBITS substance y, substance y CAUSES disease z" that link pharmaceutical substances to diseases they are known to treat. These sequences are derived from semantic predications extracted from the biomedical literature by the SemRep system, and subsequently utilized to direct the search for known treatments for a held out set of diseases. Rapid and efficient inference is accomplished through the application of geometric operators in PSI space, allowing for both the derivation of discovery patterns from a large set of known TREATS relationships, and the application of these discovered patterns to constrain search for therapeutic relationships at scale. Our results include the rediscovery of discovery patterns that have been constructed manually by other authors in previous research, as well as the discovery of a set of previously unrecognized patterns. The application of these patterns to direct search through PSI space results in better recovery of therapeutic relationships than is accomplished with models based on distributional statistics alone. These results demonstrate the utility of efficient approximate inference in geometric space as a means to identify therapeutic relationships, suggesting a role of these methods in drug repurposing efforts. In addition, the results provide strong support for the utility of the discovery pattern approach pioneered by Hristovski and his colleagues. Copyright © 2012 Elsevier Inc. All rights reserved.

Discovering discovery patterns with predication-based Semantic Indexing

PubMed Central

Cohen, Trevor; Widdows, Dominic; Schvaneveldt, Roger W.; Davies, Peter; Rindflesch, Thomas C.

2012-01-01

In this paper we utilize methods of hyperdimensional computing to mediate the identification of therapeutically useful connections for the purpose of literature-based discovery. Our approach, named Predication-based Semantic Indexing, is utilized to identify empirically sequences of relationships known as “discovery patterns”, such as “drug x INHIBITS substance y, substance y CAUSES disease z” that link pharmaceutical substances to diseases they are known to treat. These sequences are derived from semantic predications extracted from the biomedical literature by the SemRep system, and subsequently utilized to direct the search for known treatments for a held out set of diseases. Rapid and efficient inference is accomplished through the application of geometric operators in PSI space, allowing for both the derivation of discovery patterns from a large set of known TREATS relationships, and the application of these discovered patterns to constrain search for therapeutic relationships at scale. Our results include the rediscovery of discovery patterns that have been constructed manually by other authors in previous research, as well as the discovery of a set of previously unrecognized patterns. The application of these patterns to direct search through PSI space results in better recovery of therapeutic relationships than is accomplished with models based on distributional statistics alone. These results demonstrate the utility of efficient approximate inference in geometric space as a means to identify therapeutic relationships, suggesting a role of these methods in drug repurposing efforts. In addition, the results provide strong support for the utility of the discovery pattern approach pioneered by Hristovski and his colleagues. PMID:22841748

Factors affecting expression of the recF gene of Escherichia coli K-12.

PubMed

Sandler, S J; Clark, A J

1990-01-31

This report describes four factors which affect expression of the recF gene from strong upstream lambda promoters under temperature-sensitive cIAt2-encoded repressor control. The first factor was the long mRNA leader sequence consisting of the Escherichia coli dnaN gene and 95% of the dnaA gene and lambda bet, N (double amber) and 40% of the exo gene. When most of this DNA was deleted, RecF became detectable in maxicells. The second factor was the vector, pBEU28, a runaway replication plasmid. When we substituted pUC118 for pBEU28, RecF became detectable in whole cells by the Coomassie blue staining technique. The third factor was the efficiency of initiation of translation. We used site-directed mutagenesis to change the mRNA leader, ribosome-binding site and the 3 bp before and after the translational start codon. Monitoring the effect of these mutational changes by translational fusion to lacZ, we discovered that the efficiency of initiation of translation was increased 30-fold. Only an estimated two- or threefold increase in accumulated levels of RecF occurred, however. This led us to discover the fourth factor, namely sequences in the recF gene itself. These sequences reduce expression of the recF-lacZ fusion genes 100-fold. The sequences responsible for this decrease in expression occur in four regions in the N-terminal half of recF. Expression is reduced by some sequences at the transcriptional level and by others at the translational level.

Recent advances in discovery and development of natural products as source for anti-Parkinson's disease lead compounds.

PubMed

Zhang, Hongjia; Bai, Lan; He, Jun; Zhong, Lei; Duan, Xingmei; Ouyang, Liang; Zhu, Yuxuan; Wang, Ting; Zhang, Yiwen; Shi, Jianyou

2017-12-01

Parkinson's disease (PD) is a common chronic degenerative disease of the central nervous system. Although the cause remains unknown, several pathological processes and central factors such as oxidative stress, mitochondrial injury, inflammatory reactions, abnormal deposition of α-synuclein, and cell apoptosis have been reported. Currently, anti-PD drugs are classified into two major groups: drugs that affect dopaminergic neurons and anti-cholinergic drugs. Unfortunately, the existing conventional strategies against PD are with numerous side effects, and cannot fundamentally improve the degenerative process of dopaminergic neurons. Therefore, novel therapeutic approaches which have a novel structure, high efficiency, and fewer side effects are needed. For many years, natural products have provided an efficient resource for the discovery of potential therapeutic agents. Among them, many natural products possess anti-PD properties as a result of not only their wellrecognized anti-oxidative and anti-inflammatory activities but also their inhibitory roles regarding protein misfolding and the regulatory effects of PD related pathways. Indeed, with the steady improvement in the technologies for the isolation and purification of natural products and the in-depth studies on the pathogenic mechanisms of PD, many monomer components of natural products that have anti-PD effects have been gradually discovered. In this article, we reviewed the research status of 37 natural products that have been discovered to have significant anti-PD effects as well as their mode of action. Overall, this review may guide the design of novel therapeutic drugs in PD. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Protein Crystallography from the Perspective of Technology Developments

PubMed Central

Su, Xiao-Dong; Zhang, Heng; Terwilliger, Thomas C.; Liljas, Anders; Xiao, Junyu; Dong, Yuhui

2015-01-01

Early on, crystallography was a domain of mineralogy and mathematics and dealt mostly with symmetry properties and imaginary crystal lattices. This changed when Wilhelm Conrad Röntgen discovered X-rays in 1895, and in 1912 Max von Laue and his associates discovered X-ray irradiated salt crystals would produce diffraction patterns that could reveal the internal atomic periodicity of the crystals. In the same year the father-and-son team, Henry and Lawrence Bragg successfully solved the first crystal structure of sodium chloride and the era of modern crystallography began. Protein crystallography (PX) started some 20 years later with the pioneering work of British crystallographers. In the past 50-60 years, the achievements of modern crystallography and particularly those in protein crystallography have been due to breakthroughs in theoretical and technical advancements such as phasing and direct methods; to more powerful X-ray sources such as synchrotron radiation (SR); to more sensitive and efficient X-ray detectors; to ever faster computers and to improvements in software. The exponential development of protein crystallography has been accelerated by the invention and applications of recombinant DNA technology that can yield nearly any protein of interest in large amounts and with relative ease. Novel methods, informatics platforms, and technologies for automation and high-throughput have allowed the development of large-scale, high efficiency macromolecular crystallography efforts in the field of structural genomics (SG). Very recently, the X-ray free-electron laser (XFEL) sources and its applications in protein crystallography have shown great potential for revolutionizing the whole field again in the near future. PMID:25983389

Bioinformatics Analysis and Characterization of Highly Efficient Polyvinyl Alcohol (PVA)-Degrading Enzymes from the Novel PVA Degrader Stenotrophomonas rhizophila QL-P4.

PubMed

Wei, Yahong; Fu, Jing; Wu, Jianying; Jia, Xinmiao; Zhou, Yunheng; Li, Cuidan; Dong, Mengxing; Wang, Shanshan; Zhang, Ju; Chen, Fei

2018-01-01

Polyvinyl alcohol (PVA) is used widely in industry, and associated environmental pollution is a serious problem. Herein, we report a novel, efficient PVA degrader, Stenotrophomonas rhizophila QL-P4, isolated from fallen leaves from a virgin forest in the Qinling Mountains. The complete genome was obtained using single-molecule real-time (SMRT) technology and corrected using Illumina sequencing. Bioinformatics analysis revealed eight PVA/vinyl alcohol oligomer (OVA)-degrading genes. Of these, seven genes were predicted to be involved in the classic intracellular PVA/OVA degradation pathway, and one (BAY15_3292) was identified as a novel PVA oxidase. Five PVA/OVA-degrading enzymes were purified and characterized. One of these, BAY15_1712, a PVA dehydrogenase (PVADH), displayed high catalytic efficiency toward PVA and OVA substrate. All reported PVADHs only have PVA-degrading ability. Most importantly, we discovered a novel PVA oxidase (BAY15_3292) that exhibited higher PVA-degrading efficiency than the reported PVADHs. Further investigation indicated that BAY15_3292 plays a crucial role in PVA degradation in S. rhizophila QL-P4. Knocking out BAY15_3292 resulted in a significant decline in PVA-degrading activity in S. rhizophila QL-P4. Interestingly, we found that BAY15_3292 possesses exocrine activity, which distinguishes it from classic PVADHs. Transparent circle experiments further proved that BAY15_3292 greatly affects extracellular PVA degradation in S. rhizophila QL-P4. The exocrine characteristics of BAY15_3292 facilitate its potential application to PVA bioremediation. In addition, we report three new efficient secondary alcohol dehydrogenases (SADHs) with OVA-degrading ability in S. rhizophila QL-P4; in contrast, only one OVA-degrading SADH was reported previously. IMPORTANCE With the widespread application of PVA in industry, PVA-related environmental pollution is an increasingly serious issue. Because PVA is difficult to degrade, it accumulates in aquatic environments and causes chronic toxicity to aquatic organisms. Biodegradation of PVA, as an economical and environment-friendly method, has attracted much interest. To date, effective and applicable PVA-degrading bacteria/enzymes have not been reported. Herein, we report a new efficient PVA degrader ( S. rhizophila QL-P4) that has five PVA/OVA-degrading enzymes with high catalytic efficiency, among which BAY15_1712 is the only reported PVADH with both PVA- and OVA-degrading abilities. Importantly, we discovered a novel PVA oxidase (BAY15_3292) that is not only more efficient than other reported PVA-degrading PVADHs but also has exocrine activity. Overall, our findings provide new insight into PVA-degrading pathways in microorganisms and suggest S. rhizophila QL-P4 and its enzymes have the potential for application to PVA bioremediation to reduce or eliminate PVA-related environmental pollution. Copyright © 2017 American Society for Microbiology.

Electricity supply efficiency and organizational growth and profitability in Lagos, Nigeria

NASA Astrophysics Data System (ADS)

Adeleke, Adedeji Tajudeen

A modern and efficient infrastructure is a basic necessity for economic development and integration into the global economy. The specific problem was the inadequate and unreliable supply of electricity to manufacturing corporations in Lagos, Nigeria. The purpose of the current quantitative correlational research study was to examine if there was a correlation between electricity supply efficiency and organizational growth and profitability in manufacturing corporations in Lagos, Nigeria. The population of the current correlational research study involved 28 out of 34 manufacturing corporations from various industrial sectors in Lagos, Nigeria, that are listed and traded on the Nigerian Stock Exchange. Spearman rho correlations were used to assess the relationships between independent variables of electricity supply efficiency levels and the dependent variables of organizational growth and profitability. The result of the correlational analysis of the data revealed that there was a statistically significant, strong positive correlation between the Average Gross Income (1998-2007) and Average Actual Electricity supply efficiency level (1998-2007), rho = 0.57; p = 0.002. A statistically significant, strong positive correlation was found between the Average Balance Sheet Size (1998-2007) and Average Actual Electricity Supply Efficiency Level (1998-2007), rho = 0.54; p = 0.003. A statistically significant, strong positive correlation between the Average Profit After Tax (1998-2007) and Average Actual Electricity Supply Efficiency Level (1998-2007), rho = 0.60; p = 0.001, was found. No statistically significant correlation between the Average Return on Investment (1998-2007) and Average Actual Electricity supply efficiency level (1998-2007), rho = 0.19; p = 0.33, was discovered.

High Mobility and Low Use of Malaria Preventive Measures among the Jarai Male Youth along the Cambodia–Vietnam Border

PubMed Central

Gryseels, Charlotte; Peeters Grietens, Koen; Dierickx, Susan; Xuan, Xa Nguyen; Uk, Sambunny; Bannister-Tyrrell, Melanie; Trienekens, Suzan; Ribera, Joan Muela; Hausmann-Muela, Susanna; Gerrets, René; D'Alessandro, Umberto; Sochantha, Tho; Coosemans, Marc; Erhart, Annette

2015-01-01

Malaria control along the Vietnam–Cambodia border presents a challenge for both countries' malaria elimination targets as the region is forested, inhabited by ethnic minority populations, and potentially characterized by early and outdoor malaria transmission. A mixed methods study assessed the vulnerability to malaria among the Jarai population living on both sides of the border in the provinces of Ratanakiri (Cambodia) and Gia Lai (Vietnam). A qualitative study generated preliminary hypotheses that were quantified in two surveys, one targeting youth (N = 498) and the other household leaders (N = 449). Jarai male youth, especially in Cambodia, had lower uptake of preventive measures (57.4%) and more often stayed overnight in the deep forest (35.8%) compared with the female youth and the adult population. Among male youth, a high-risk subgroup was identified that regularly slept at friends' homes or outdoors, who had fewer bed nets (32.5%) that were torn more often (77.8%). The vulnerability of Jarai youth to malaria could be attributed to the transitional character of youth itself, implying less fixed sleeping arrangements in nonpermanent spaces or non-bed sites. Additional tools such as long-lasting hammock nets could be suitable as they are in line with current practices. PMID:26283747

KSC-2012-4855

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, and NASA's new mobile launcher, or ML, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The 355-foot-tall ML structure, which took about two years to construct, will be modified by NASA’s Ground Systems Development and Operations, or GSDO, Program to support NASA’s Space Launch System, the heavy-lift rocket that will launch astronauts into deep space on future exploration missions. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4865

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, and NASA's new mobile launcher, or ML, are seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The 355-foot-tall ML structure, which took about two years to construct, will be modified by NASA’s Ground Systems Development and Operations, or GSDO, Program to support NASA’s Space Launch System, the heavy-lift rocket that will launch astronauts into deep space on future exploration missions. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4860

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, and NASA's new mobile launcher, or ML, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The 355-foot-tall ML structure, which took about two years to construct, will be modified by NASA’s Ground Systems Development and Operations, or GSDO, Program to support NASA’s Space Launch System, the heavy-lift rocket that will launch astronauts into deep space on future exploration missions. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4864

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, and NASA's new mobile launcher, or ML, are seen during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The 355-foot-tall ML structure, which took about two years to construct, will be modified by NASA’s Ground Systems Development and Operations, or GSDO, Program to support NASA’s Space Launch System, the heavy-lift rocket that will launch astronauts into deep space on future exploration missions. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

KSC-2012-4859

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – The Vehicle Assembly Building, or VAB, and NASA's new mobile launcher, or ML, are seen in the distance during a field-guided boat tour of NASA's Kennedy Space Center in Florida. As part of the center's first-ever Innovation Expo, the tour, called "Living Outdoor Laboratory for Environmental Sustainability," is giving employees the opportunity to see the unique estuarine ecosystems that are protected from development by the presence of Kennedy and the Merritt Island National Wildlife Refuge. The 355-foot-tall ML structure, which took about two years to construct, will be modified by NASA’s Ground Systems Development and Operations, or GSDO, Program to support NASA’s Space Launch System, the heavy-lift rocket that will launch astronauts into deep space on future exploration missions. The diverse and healthy area encompassing about 140,000 acres of central Florida's east coast has been closed to the public for 50 years, allowing the coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks to provide habitats for more than 1,000 species of plants and animals. Innovation Expo is showcasing the innovative work taking place throughout the center's facilities and labs to encourage employees to work together to solve future challenges. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA

Embedding covalency into metal catalysts for efficient electrochemical conversion of CO2.

PubMed

Lim, Hyung-Kyu; Shin, Hyeyoung; Goddard, William A; Hwang, Yun Jeong; Min, Byoung Koun; Kim, Hyungjun

2014-08-13

CO2 conversion is an essential technology to develop a sustainable carbon economy for the present and the future. Many studies have focused extensively on the electrochemical conversion of CO2 into various useful chemicals. However, there is not yet a solution of sufficiently high enough efficiency and stability to demonstrate practical applicability. In this work, we use first-principles-based high-throughput screening to propose silver-based catalysts for efficient electrochemical reduction of CO2 to CO while decreasing the overpotential by 0.4-0.5 V. We discovered the covalency-aided electrochemical reaction (CAER) mechanism in which p-block dopants have a major effect on the modulating reaction energetics by imposing partial covalency into the metal catalysts, thereby enhancing their catalytic activity well beyond modulations arising from d-block dopants. In particular, sulfur or arsenic doping can effectively minimize the overpotential with good structural and electrochemical stability. We expect this work to provide useful insights to guide the development of a feasible strategy to overcome the limitations of current technology for electrochemical CO2 conversion.

Design and Analysis of Cost-Efficient Sensor Deployment for Tracking Small UAS with Agent-Based Modeling.

PubMed

Shin, Sangmi; Park, Seongha; Kim, Yongho; Matson, Eric T

2016-04-22

Recently, commercial unmanned aerial systems (UAS) have gained popularity. However, these UAS are potential threats to people in terms of safety in public places, such as public parks or stadiums. To reduce such threats, we consider a design, modeling, and evaluation of a cost-efficient sensor system that detects and tracks small UAS. In this research, we focus on discovering the best sensor deployments by simulating different types and numbers of sensors in a designated area, which provide reasonable detection rates at low costs. Also, the system should cover the crowded areas more thoroughly than vacant areas to reduce direct threats to people underneath. This research study utilized the Agent-Based Modeling (ABM) technique to model a system consisting of independent and heterogeneous agents that interact with each other. Our previous work presented the ability to apply ABM to analyze the sensor configurations with two types of radars in terms of cost-efficiency. The results from the ABM simulation provide a list of candidate configurations and deployments that can be referred to for applications in the real world environment.

Design and Analysis of Cost-Efficient Sensor Deployment for Tracking Small UAS with Agent-Based Modeling

PubMed Central

Shin, Sangmi; Park, Seongha; Kim, Yongho; Matson, Eric T.

2016-01-01

Recently, commercial unmanned aerial systems (UAS) have gained popularity. However, these UAS are potential threats to people in terms of safety in public places, such as public parks or stadiums. To reduce such threats, we consider a design, modeling, and evaluation of a cost-efficient sensor system that detects and tracks small UAS. In this research, we focus on discovering the best sensor deployments by simulating different types and numbers of sensors in a designated area, which provide reasonable detection rates at low costs. Also, the system should cover the crowded areas more thoroughly than vacant areas to reduce direct threats to people underneath. This research study utilized the Agent-Based Modeling (ABM) technique to model a system consisting of independent and heterogeneous agents that interact with each other. Our previous work presented the ability to apply ABM to analyze the sensor configurations with two types of radars in terms of cost-efficiency. The results from the ABM simulation provide a list of candidate configurations and deployments that can be referred to for applications in the real world environment. PMID:27110790

Stacking multiple connecting functional materials in tandem organic light-emitting diodes

PubMed Central

Zhang, Tao; Wang, Deng-Ke; Jiang, Nan; Lu, Zheng-Hong

2017-01-01

Tandem device is an important architecture in fabricating high performance organic light-emitting diodes and organic photovoltaic cells. The key element in making a high performance tandem device is the connecting materials stack, which plays an important role in electric field distribution, charge generation and charge injection. For a tandem organic light-emitting diode (OLED) with a simple Liq/Al/MoO3 stack, we discovered that there is a significant current lateral spreading causing light emission over an extremely large area outside the OLED pixel when the Al thickness exceeds 2 nm. This spread light emission, caused by an inductive electric field over one of the device unit, limits one’s ability to fabricate high performance tandem devices. To resolve this issue, a new connecting materials stack with a C60 fullerene buffer layer is reported. This new structure permits optimization of the Al metal layer in the connecting stack and thus enables us to fabricate an efficient tandem OLED having a high 155.6 cd/A current efficiency and a low roll-off (or droop) in current efficiency. PMID:28225028

The modeling of gold recovery from tetrachloroaurate wastewater using a microbial fuel cell.

PubMed

Choi, Chansoo; Hu, Naixu

2013-04-01

In this study, tetrachloroaurate as an electron acceptor of a microbial fuel cell (MFC) has been studied to discover the parameters that affect the cost-effective recovery of gold. The modeling and equations for calculating the maximum actual efficiency and electrochemical impedance spectroscopic internal resistance of the MFC were also developed. The maximum power density (Pmax) of 6.58 W/m(2) with a fill factor of 0.717 was achieved for 60 mL volumes of 2000 ppm Au(III) catholyte and 12.2 mM acetate anolyte, respectively. The Pmax can also be predicted simply by measuring Rint by EIS. Additionally, the maximum actual MFC efficiency of about 57% was achieved, and the recovery efficiency of Au and the remaining concentration reached 99.89±0.00% and 0.22±0.00 ppm, respectively, for an Au(III) concentration of 200 ppm. The anodic concentration polarization quenching of the MFC strongly supports a mediator mechanism for the electron transfer from the microorganism to the anode. Copyright © 2013 Elsevier Ltd. All rights reserved.

Role of intermolecular charge delocalization and its dimensionality in efficient band-like electron transport in crystalline 2,5-difluoro-7,7,8,8-tetracyanoquinodimethane (F2-TCNQ).

PubMed

Sosorev, Andrey Yu

2017-09-27

Theoretical understanding of charge transport in organic semiconductors is exclusively important for organic electronics, but still remains a subject of debate. The recently discovered record-high band-like electron mobility in single crystals of 2,5-difluoro-7,7,8,8-tetracyanoquinodimethane (F 2 -TCNQ) is challenging from the theoretical viewpoint. First, the very small size of the F 2 -TCNQ molecule implies high reorganization energy that seems incompatible with efficient charge transport. Second, it is not clear why the crystals of a similar compound, 7,7,8,8-tetracyanoquinodimethane (TCNQ), show an inefficient hopping electron transport mechanism. To address these issues, we apply DFT and QM/MM calculations to the F n -TCNQ (n = 0,2,4) crystal series. We show that multidimensional intermolecular charge delocalization is of key importance for efficient charge transport in materials consisting of small-sized molecules, and commonly used guidelines for the search for high-mobility organic semiconductors are to be corrected.

Stacking multiple connecting functional materials in tandem organic light-emitting diodes

NASA Astrophysics Data System (ADS)

Zhang, Tao; Wang, Deng-Ke; Jiang, Nan; Lu, Zheng-Hong

2017-02-01

Tandem device is an important architecture in fabricating high performance organic light-emitting diodes and organic photovoltaic cells. The key element in making a high performance tandem device is the connecting materials stack, which plays an important role in electric field distribution, charge generation and charge injection. For a tandem organic light-emitting diode (OLED) with a simple Liq/Al/MoO3 stack, we discovered that there is a significant current lateral spreading causing light emission over an extremely large area outside the OLED pixel when the Al thickness exceeds 2 nm. This spread light emission, caused by an inductive electric field over one of the device unit, limits one’s ability to fabricate high performance tandem devices. To resolve this issue, a new connecting materials stack with a C60 fullerene buffer layer is reported. This new structure permits optimization of the Al metal layer in the connecting stack and thus enables us to fabricate an efficient tandem OLED having a high 155.6 cd/A current efficiency and a low roll-off (or droop) in current efficiency.