78 FR 7813 - Sanjay Trivedi, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-57] Sanjay Trivedi, M.D....100(b), I order that DEA Certificate of Registration FT0896754, issued to Sanjay Trivedi, M.D., be, and it hereby is, revoked. I further order that any pending application of Sanjay Trivedi, M.D., to...

77 FR 50543 - Meeting of Advisory Committee on International Communications and Information Policy

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-21

... Communications and Information Policy The Department of State's Advisory Committee on International Communications and Information Policy (ACICIP) will hold a public meeting on October 2, 2012 from 9:00 a.m. to 12... issues and problems in international communications and information policy, especially as these issues...

Adolescent peer crowds and patterns of belief in the boundaries of personal authority.

PubMed

Daddis, Christopher

2010-10-01

Patterns of authority beliefs were examined among peer crowds in 598 middle school (M=12.97 years), early high school (M=15.10 years), and late high school adolescents (M=18.25 years). Participants reported beliefs regarding the boundaries of personal authority across personal, prudential, conventional, moral, and multifaceted issues. As expected, analyses revealed persistent differences in belief patterns among crowds within each age group. Tough and Alternative crowds asserted personal authority across all issues, while Prep and Outcast crowds endorsed parental authority. Jock, Hip Hop, and Normal crowds presented with shared-control patterns, but each crowd ceded and asserted authority over different issues. Discussion focused on crowds' roles in the development of group differences in the boundaries of personal authority.

Nutrition and Young Children.

ERIC Educational Resources Information Center

Frank, Mary, Ed.; And Others

1978-01-01

The special issue of the journal contains 12 articles on nutrition and young children. The following titles and authors are included: "Overview--Nutritional Needs of Young Children" (M. Scialabba); "Nurturance--Mutually Created--Mother and Child" (M. McFarland); "Feeding the Special Needs Child" (E. Croup); "Maternal and Neonatal Nutrition--Long…

77 FR 36604 - Office of Hazardous Materials Safety Actions on Special Permit Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

... special permits were issued. Issued in Washington, DC, on June 12, 2012. Donald Burger, Chief, Special.... 15531-M National Aeronautics 49 CFR Section To modify the special permit originally and Space 173.302(a... prior to shipment. (mode 2) EMERGENCY SPECIAL PERMIT GRANTED 15634-N SodaStream USA Inc., 49 CFR 171.2(k...

75 FR 1088 - Board of Governors; Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... POSTAL SERVICE Board of Governors; Sunshine Act Meeting TIMES AND DATES: 3:30 p.m., Monday, January 11, 2010; and 7:30 a.m., Tuesday, January 12, 2010. PLACE: Newport Beach, California, at the Fairmont Hotel, 4500 MacArthur Boulevard. STATUS: (Closed) MATTERS TO BE CONSIDERED: Monday, January 11, at 3:30 p.m. (Closed) 1. Strategic Issues. 2....

78 FR 22890 - National Advisory Council on Migrant Health; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-17

... Advisory Council on Migrant Health; Notice of Meeting In accordance with section 217 of the Public Health... Migrant Health Dates and Times: May 21, 2013, 8:30 a.m. to 5:00 p.m. May 22, 2013, 8:00 a.m. to 12:00 p.m.... Purpose: The purpose of the meeting is to discuss services and issues related to the health of migrant and...

76 FR 24080 - Houston District Office Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... is issuing this notice to announce the location, date, time, and agenda for the next meeting of the... will be held on May 24, 2011 from approximately 11:30 a.m. to 12:30 p.m. Central Standard Time... we can better serve our community and to create new networking opportunities with the Houston...

12 CFR Appendix C to Part 213 - Issuance of Staff Interpretations

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Issuance of Staff Interpretations C Appendix C... CONSUMER LEASING (REGULATION M) Pt. 213, App. C Appendix C to Part 213—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff...

12 CFR Appendix C to Part 213 - Issuance of Staff Interpretations

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 2 2011-01-01 2011-01-01 false Issuance of Staff Interpretations C Appendix C... CONSUMER LEASING (REGULATION M) Pt. 213, App. C Appendix C to Part 213—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff...

12 CFR Appendix C to Part 213 - Issuance of Staff Interpretations

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 2 2013-01-01 2013-01-01 false Issuance of Staff Interpretations C Appendix C... CONSUMER LEASING (REGULATION M) Pt. 213, App. C Appendix C to Part 213—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff...

12 CFR Appendix C to Part 213 - Issuance of Staff Interpretations

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Issuance of Staff Interpretations C Appendix C... CONSUMER LEASING (REGULATION M) Pt. 213, App. C Appendix C to Part 213—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff...

12 CFR Appendix C to Part 213 - Issuance of Staff Interpretations

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 2 2012-01-01 2012-01-01 false Issuance of Staff Interpretations C Appendix C... CONSUMER LEASING (REGULATION M) Pt. 213, App. C Appendix C to Part 213—Issuance of Staff Interpretations Officials in the Board's Division of Consumer and Community Affairs are authorized to issue official staff...

Tank waste remediation system nuclear criticality safety program management review

DOE Office of Scientific and Technical Information (OSTI.GOV)

BRADY RAAP, M.C.

1999-06-24

This document provides the results of an internal management review of the Tank Waste Remediation System (TWRS) criticality safety program, performed in advance of the DOE/RL assessment for closure of the TWRS Nuclear Criticality Safety Issue, March 1994. Resolution of the safety issue was identified as Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) Milestone M-40-12, due September 1999.

76 FR 22161 - Fifty Seventh Meeting: RTCA Special Committee 135, Environmental Conditions and Test Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... Committee 135, Environmental Conditions and Test Procedures for Airborne Equipment AGENCY: Federal Aviation...: Environmental Conditions and Test Procedures for Airborne Equipment. SUMMARY: The FAA is issuing this notice to... Procedures for Airborne Equipment. DATES: The meeting will be held May 11-12, 2011 from 9 a.m.-5 p.m...

Current Warm-Up Practices and Contemporary Issues Faced by Elite Swimming Coaches.

PubMed

McGowan, Courtney J; Pyne, David B; Raglin, John S; Thompson, Kevin G; Rattray, Ben

2016-12-01

McGowan, CJ, Pyne, DB, Raglin, JS, Thompson, KG, and Rattray, B. Current warm-up practices and contemporary issues faced by elite swimming coaches. J Strength Cond Res 30(12): 3471-3480, 2016-A better understanding of current swimming warm-up strategies is needed to improve their effectiveness. The purpose of this study was to describe current precompetition warm-up practices and identify contemporary issues faced by elite swimming coaches during competition. Forty-six state-international level swimming coaches provided information through a questionnaire on their prescription of volume, intensity, and recovery within their pool and dryland-based competition warm-ups, and challenges faced during the final stages of event preparation. Coaches identified four key objectives of the precompetition warm-up: physiological (elevate body temperature and increase muscle activation), kinesthetic (tactile preparation, increase "feel" of the water), tactical (race-pace rehearsal), and mental (improve focus, reduce anxiety). Pool warm-up volume ranged from ∼1300 to 2100 m, beginning with 400-1000 m of continuous, low-intensity (∼50-70% of perceived maximal exertion) swimming, followed by 200-600 m of stroke drills and 1-2 sets (100-400 m in length) of increasing intensity (∼60-90%) swimming, concluding with 3-4 race or near race-pace efforts (25-100 m; ∼90-100%) and 100-400 m easy swimming. Dryland-based warm-up exercises, involving stretch cords and skipping, were also commonly prescribed. Coaches preferred swimmers complete their warm-up 20-30 minutes before race start. Lengthy marshalling periods (15-20+ minutes) and the time required to don racing suits (>10 minutes) were identified as complicating issues. Coaches believed that the pool warm-up affords athletes the opportunity to gain a tactile feel for the water and surrounding pool environment. The combination of dryland-based activation exercises followed by pool-based warm-up routines seems to be the preferred approach taken by elite swimming coaches preparing their athletes for competition.

Critical (of) Issues in Real-Time Systems.

DTIC Science & Technology

1988-05-03

IACCESON 11 T IT LE (Include Security Classification) Cr it ic, (of) issues in real .- time systems A Position Paper 12 PERPSONAL AU THOR(S) Fr ed B...are obsolete %0%’ 4.’.C %" Critical (of) issues in real - time systems ’ • "A Position Paper Acc, son For NTIS R& DTrC TAB May 3, 1988 Uyjannotuce~d...m . 2C:. r Ithaca, New York 14853 Dist 1 -.1 g- It is time to place the development of real - time systems on a firm scientific basis. Unlike other

Differential Associations between Domains of Sibling Conflict and Adolescent Emotional Adjustment

ERIC Educational Resources Information Center

Campione-Barr, Nicole; Greer, Kelly Bassett; Kruse, Anna

2013-01-01

Issues of equality and fairness and invasion of the personal domain, 2 previously identified topic areas of adolescent sibling conflict (N. Campione-Barr & J. G. Smetana, 2010), were examined in 145 dyads ("M" [subscript first-born] = 14.97, "SD" = 1.69 years; "M" [subscript second-born] = 12.20,…

77 FR 13621 - Notice of Public Meeting, Eastern Montana Resource Advisory Council Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... Office manager updates, subcommittee briefings, work sessions and other issues that the council may raise..., 2012. M. Elaine Raper, Eastern Montana--Dakotas District Manager. [FR Doc. 2012-5492 Filed 3-6-12; 8:45...

Neck Torque Study Induced by Head-Borne Visual Augmentation Systems (VAS) in Ground-Based Applications. Version V1.2

DTIC Science & Technology

2010-04-01

Standard Issue M, L and  XL  ACH  AN/PVS‐14  Norotos, Standard Issue M, L and  XL  ACH  AN/PVS‐15  Norotos Low Profile, (USASOC) Wilcox Low Profile...WARCOM)  M, L and  XL  ACH  AN/PVS‐23  ITT F5050 (USASOC) M, L and  XL  ACH   Fusion Goggles  ITT F5050 (USASOC)  M, L and  XL  ACH and SOCOM  LWH – Large  AN...PEQ‐20  AN/PEQ‐20 ENVG Mount M, L and  XL  ACH  ADM‐NVG  ADM  Wilcox Mount  M, L and  XL  ACH and SOCOM  Lightweight Helmet (LWH) ‐ Large  FGS‐PI  ITT F5050

The Atacama Compact Array: An Overview

NASA Astrophysics Data System (ADS)

Iguchi, S.; Wilson, T. L.

2010-01-01

When completed, ALMA will comprise a 12-meter diameter antennas array (12-m Array) of a minimum of fifty antennas, and the ACA (Atacama Compact Array), composed of four 12-meter diameter antennas and twelve 7-meter diameter antennas. Out of the fifty antennas of the 12-m Array, one-half are provided by the North American partners of ALMA, the other half by the European partners. The sixteen antennas that will comprise the ACA are provided by the East Asian Partners of ALMA. In the last issue of the ALMA Science Newsletter, we outlined the testing of the prototype ALMA 12-meter diameter antennas and the procurement process for these antennas. In that article, only a short account was given of the antennas for the Atacama Compact Array (ACA). In the following we give an overview of the ACA, starting with an introduction to imaging using interferometers.

Testing of the KRI-developed Silicon PIN Radioxenon Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foxe, Michael P.; McIntyre, Justin I.

Radioxenon detectors are used for the verification of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) in a network of detectors throughout the world called the International Monitoring System (IMS). The Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) Provisional Technical Secretariat (PTS) has tasked Pacific Northwest National Laboratory (PNNL) with testing a V.G. Khlopin Radium Institute (KRI) and Lares Ltd-developed Silicon PIN detector for radioxenon detection. PNNL measured radioxenon with the silicon PIN detector and determined its potential compared to current plastic scintillator beta cells. While the PNNL tested Si detector experienced noise issues, a second detector was tested in Russia at Lares Ltd, whichmore » did not exhibit the noise issues. Without the noise issues, the Si detector produces much better energy resolution and isomer peak separation than a conventional plastic scintillator cell used in the SAUNA systems in the IMS. Under the assumption of 1 cm 3 of Xe in laboratory-like conditions, 24-hr count time (12-hr count time for the SAUNA), with the respective shielding the minimum detectable concentrations for the Si detector tested by Lares Ltd (and a conventional SAUNA system) were calculated to be: 131mXe – 0.12 mBq/m 3 (0.12 mBq/m 3); 133Xe – 0.18 mBq/m 3 (0.21 mBq/m 3); 133mXe – 0.07 mBq/m 3 (0.15 mBq/m 3); 135Xe – 0.45 mBq/m 3 (0.67 mBq/m 3). Detection limits, which are one of the important factors in choosing the best detection technique for radioxenon in field conditions, are significantly better than for SAUNA-like detection systems for 131mXe and 133mXe, but similar for 133Xe and 135Xe. Another important factor is the amount of “memory effect” or carry over signal from one radioxenon measurement to the subsequent sample. The memory effect is reduced by a factor of 10 in the Si PIN detector compared to the current plastic scintillator cells. There is potential for further reduction with the removal of plastics within the cell, which will need to be explored in future work. A third important parameter in choosing the best detection technique for radioxenon is the resolution of the electron detection. While the resolution is important in determining the minimum detectable concentration, it plays a larger role in source identification when there is a visible signal. The Silicon PIN diodes generated improved resolution over a similar plastic scintillator cell. With the improved resolution, it becomes easier to distinguish the radioxenon isomers ( 133mXe and 131mXe) from the 133Xe beta continuum background. With the beta background from 133Xe ever present with the detection of the isomers, the improved resolution proves vital in calculating the ratios of the three isotopes. With an accurate measurement of the isotopic ratios, the anthropogenic sources of radioxenon (medical isotope production and nuclear reactors) can be more accurately distinguished. Based on the results shown within this report, a Si PIN beta cell shows the potential to aid in the operation and discriminating power of the IMS for the CTBTO. However, there are a number of issues that need attention before a detector of this design would be reliable enough for field operations in the IMS. Issues that need develop include, but are not limited to: studying the robustness of the design in field conditions, eliminating or minimizing the noise and variability of individual Si detector elements, understanding the long-term gain stability of the Si detectors, and reducing the non-Si materials within the cell (i.e. the plastic housing).« less

Economic Feasibility of a Siderostat-fed Liquid Mirror Telescope for Surveillance of Space

DTIC Science & Technology

2015-04-01

in 1979 [11], and the 4.1 m Southern Observatory for Astrophysical Research, SOAR , telescope cost $28M USD to construct [12]). The issue with LMTs is...relationship, a 4 m class telescope would cost roughly $30M USD, in line with the costs of the CFHT and SOAR provided in Section 1. In Table 1 the component...quality of the HET is less than that of SOAR because HET is exclusively a spectroscopic instrument, while SALT is more general purpose and will be

An Assessment of Air Force Development Portfolio Management Practices

DTIC Science & Technology

2002-01-01

of Product Innovation Management , 12, 235–246. Cooper, R. G., & Kleinschmidt, E. J. (1995). Benchmarking the firm’s criti- cal success factors in new...product development. Journal of Product Innovation Management , 12, 374– 391. Cooper, R. G., Edgett, S. J., & Klein- schmidt, E. J. (1998a). Best...Scott, G. M. (2000). Critical technology management issues of new product development in high-tech companies. Journal of Product Innovation Management , 17

Essential Readings in Gifted Education: 12 Volume Set

ERIC Educational Resources Information Center

Reis, Sally M., Ed.

2004-01-01

The National Association for Gifted Children series "Essential Readings in Gifted Education," edited by Sally M. Reis, is a comprehensive collection of the leading research, theories, and findings that span more than 25 years. Each volume tackles the major issues, chronicles chief trends, and imparts effective models and solutions for gifted…

36 CFR 7.58 - Cape Hatteras National Seashore.

Code of Federal Regulations, 2011 CFR

2011-07-01

... accordance with the rules and regulations issued by the North Carolina Wildlife Resources Commission and the U.S. Fish and Wildlife Service. (6) Hunting privileges will be free for all hunters possessing a... accepted through the United States mail only. Reservations postmarked prior to 12:01 a.m. of September 25...

77 FR 41451 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... INTERNATIONAL TRADE COMMISSION [USITC SE-12-019] Sunshine Act Meeting AGENCY HOLDING THE MEETING: International Trade Commission. TIME AND DATE: July 19, 2012 at 11:00 a.m. PLACE: Room 100, 500 E Street SW... following meeting. By order of the Commission: Issued: July 9, 2012. Lisa R. Barton, Acting Secretary to the...

Managing Colleges and Universities: Issues for Leadership.

ERIC Educational Resources Information Center

Hoffman, Allan M., Ed.; Summers, Randal W., Ed.

This collection of papers highlights topics relating to leadership in higher education. After a "Foreword" (Dean L. Hubbard) and "Introduction" (Allan M. Hoffman and Randal W. Summers), the 12 chapters are: (1) "Organizational Structure, Management, and Leadership for the Future" (Richard Alfred and Scott Rosevear); (2) "The Practitioner's…

The One-Meter Criterion for Tsunami Warning: Time for a Reevaluation?

NASA Astrophysics Data System (ADS)

Fryer, G. J.; Weinstein, S.

2013-12-01

The U.S. tsunami warning centers issue warnings when runup is anticipated to exceed one meter. The origins of the one-meter criterion are unclear, though Whitmore, et al (2008) showed from tsunami history that one meter is roughly the threshold above which damage occurs. Recent experiences in Hawaii, however, suggest that the threshold could be raised. Tsunami Warnings were issued for 2010 Chile, 2011 Tohoku, and 2012 Haida Gwaii tsunamis; each exceeded one meter runup somewhere in the State. Evacuation, however, was necessary only in 2011, and even then onshore damage (as opposed to damage from currents) occurred only where runup exceeded 1.5m. During both Chile and Haida Gwaii tsunamis the existing criteria led to unnecessary evacuation. Maximum runup during the Chile tsunami was 1.1m at Hilo's Wailoa Boat Harbor, while the Haida Gwaii tsunami peaked at 1.2m at Honouliwai Bay on Molokai. Both tsunamis caused only minor damage and minimal flooding; in both cases a Tsunami Advisory (i.e., there is no need to evacuate, but stay off the beach and out of the water) would have been adequate. The Advisory was originally developed as an ad hoc response to the mildly threatening 2006 Kuril tsunami and has since been formalized as the product we issue when maximum runup is expected to be 0.3-1.0 m. At the time it was introduced, however, there was no discussion that this new low-level warning might allow the criterion for Tsunami Warning itself to be adjusted. We now suggest that the divide between Advisory and Warning be raised from 1.0 to something greater, possibly 1.2m. If the warning threshold were raised to 1.2m, the over-warning for the Chile tsunami still could not have been avoided. Models calibrated against DART data consistently forecast runup just over 1.2m for that event. For Haida Gwaii, adjusting the models to match the DART data increased the forecast runup to almost 2m, which again meant a warning, though in retrospect we should have been skeptical. The nearest DART to Haida Gwaii was off the Washington coast in line with the long axis (strike direction) of the rupture and so provided little constraint on the tsunami directed towards Hawaii (the dip direction). The finite fault model obtained by inverting the DART data extended the rupture too far along strike and pushed the rupture to the wrong (east) side of Haida Gwaii, in conflict with the W-phase CMT. The inferred wave height at the Langara Point tide gauge, just outside the epicentral region, was also too large by a factor of two. Forcing the tsunami inversion to be consistent with the CMT would have rendered the inferred rupture much closer to reality, matched the Langara Point record well, and forecast a maximum runup at Kahului of only 1.0 m (the actual runup there was 0.8m). If the warning criterion had been 1.2m the unnecessary coastal evacuation for the Haida Gwaii tsunami could have been avoided. So increasing the warning threshold by only 20 cm would eliminate one of the two recent unnecessary evacuations. Can the threshold be be raised even more? We are considering that possibility, though the uncertainties and time constraints of an actual warning demand that we remain very conservative.

17 CFR 12.312 - Oral hearing.

Code of Federal Regulations, 2014 CFR

2014-04-01

... location of an oral hearing shall be in one of the following cities: Albuquerque, N.M.; Atlanta, Ga... issues to be tried at the hearing; (ii) An identification of each witness expected to be called by that..., which, unless modified to prevent injustice, shall control the scope of matters to be tried at the oral...

17 CFR 12.312 - Oral hearing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... location of an oral hearing shall be in one of the following cities: Albuquerque, N.M.; Atlanta, Ga... issues to be tried at the hearing; (ii) An identification of each witness expected to be called by that..., which, unless modified to prevent injustice, shall control the scope of matters to be tried at the oral...

17 CFR 12.312 - Oral hearing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... location of an oral hearing shall be in one of the following cities: Albuquerque, N.M.; Atlanta, Ga... issues to be tried at the hearing; (ii) An identification of each witness expected to be called by that..., which, unless modified to prevent injustice, shall control the scope of matters to be tried at the oral...

17 CFR 12.312 - Oral hearing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... location of an oral hearing shall be in one of the following cities: Albuquerque, N.M.; Atlanta, Ga... issues to be tried at the hearing; (ii) An identification of each witness expected to be called by that..., which, unless modified to prevent injustice, shall control the scope of matters to be tried at the oral...

17 CFR 12.312 - Oral hearing.

Code of Federal Regulations, 2012 CFR

2012-04-01

... location of an oral hearing shall be in one of the following cities: Albuquerque, N.M.; Atlanta, Ga... issues to be tried at the hearing; (ii) An identification of each witness expected to be called by that..., which, unless modified to prevent injustice, shall control the scope of matters to be tried at the oral...

76 FR 65936 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-25

..., Docket Operations, M-30, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE... was a result of installation defects during production, and the issues related to wiring segregation... here. Based on these figures, we estimate the cost of this AD to the U.S. operators to be up to $499...

78 FR 22432 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

... electrical rudder], through Airbus Service Bulletin (SB) A330-27-3176, --software standard P12A/M21A on FCPC.... Since we issued that AD, we have determined that new software standards for the flight control primary.... This proposed AD would require that operators modify or replace all three FCPCs with new software...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poloski, Adam P.; Adkins, Harold E.; Abrefah, John

The WTP pipe plugging issue, as stated by the External Flowsheet Review Team (EFRT) Executive Summary, is as follows: “Piping that transports slurries will plug unless it is properly designed to minimize this risk. This design approach has not been followed consistently, which will lead to frequent shutdowns due to line plugging.” A strategy was employed to perform critical-velocity tests on several physical simulants. Critical velocity is defined as the point where a stationary bed of particles deposits on the bottom of a straight horizontal pipe during slurry transport operations. Results from the critical velocity testing provide an indication ofmore » slurry stability as a function of fluid rheological properties and transport conditions. The experimental results are compared to the WTP design guide on slurry transport velocity in an effort to confirm minimum waste velocity and flushing velocity requirements as established by calculations and critical line velocity correlations in the design guide. The major findings of this testing is discussed below. Experimental results indicate that the use of the Oroskar and Turian (1980) correlation in the design guide is conservative—Slurry viscosity has a greater affect on particles with a large surface area to mass ratio. The increased viscous forces on these particles result in a decrease in predicted critical velocities from this traditional industry derived equations that focus on particles large than 100 μm in size. Since the Hanford slurry particles generally have large surface area to mass ratios, the reliance on such equations in the Hall (2006) design guide is conservative. Additionally, the use of the 95% percentile particle size as an input to this equation is conservative. However, test results indicate that the use of an average particle density as an input to the equation is not conservative. Particle density has a large influence on the overall result returned by the correlation. Lastly, the viscosity correlation used in the WTP design guide has been shown to be inaccurate for Hanford waste feed materials. The use of the Thomas (1979) correlation in the design guide is not conservative—In cases where 100% of the particles are smaller than 74 μm or particles are considered to be homogeneous due to yield stress forces suspending the particles the homogeneous fraction of the slurry can be set to 100%. In such cases, the predicted critical velocity based on the conservative Oroskar and Turian (1980) correlation is reduced to zero and the design guide returns a value from the Thomas (1979) correlation. The measured data in this report show that the Thomas (1979) correlation predictions often fall below that measured experimental values. A non-Newtonian deposition velocity design guide should be developed for the WTP— Since the WTP design guide is limited to Newtonian fluids and the WTP expects to process large quantities of such materials, the existing design guide should be modified address such systems. A central experimental finding of this testing is that the flow velocity required to reach turbulent flow increases with slurry rheological properties due to viscous forces dampening the formation of turbulent eddies. The flow becomes dominated by viscous forces rather than turbulent eddies. Since the turbulent eddies necessary for particle transport are not present, the particles will settle when crossing this boundary called the transitional deposition boundary. This deposition mechanism should be expected and designed for in the WTP.« less

Garnet-type solid-state fast Li ion conductors for Li batteries: critical review.

PubMed

Thangadurai, Venkataraman; Narayanan, Sumaletha; Pinzaru, Dana

2014-07-07

Batteries are electrochemical devices that store electrical energy in the form of chemical energy. Among known batteries, Li ion batteries (LiBs) provide the highest gravimetric and volumetric energy densities, making them ideal candidates for use in portable electronics and plug-in hybrid and electric vehicles. Conventional LiBs use an organic polymer electrolyte, which exhibits several safety issues including leakage, poor chemical stability and flammability. The use of a solid-state (ceramic) electrolyte to produce all-solid-state LiBs can overcome all of the above issues. Also, solid-state Li batteries can operate at high voltage, thus, producing high power density. Various types of solid Li-ion electrolytes have been reported; this review is focused on the most promising solid Li-ion electrolytes based on garnet-type metal oxides. The first studied Li-stuffed garnet-type compounds are Li5La3M2O12 (M = Nb, Ta), which show a Li-ion conductivity of ∼10(-6) at 25 °C. La and M sites can be substituted by various metal ions leading to Li-rich garnet-type electrolytes, such as Li6ALa2M2O12, (A = Mg, Ca, Sr, Ba, Sr0.5Ba0.5) and Li7La3C2O12 (C = Zr, Sn). Among the known Li-stuffed garnets, Li6.4La3Zr1.4Ta0.6O12 exhibits the highest bulk Li-ion conductivity of 10(-3) S cm(-1) at 25 °C with an activation energy of 0.35 eV, which is an order of magnitude lower than that of the currently used polymer, but is chemically stable at higher temperatures and voltages compared to polymer electrolytes. Here, we discuss the chemical composition-structure-ionic conductivity relationship of the Li-stuffed garnet-type oxides, as well as the Li ion conduction mechanism.

Physical and mental quality of life in adult patients with haemophilia in Belgium: the impact of financial issues.

PubMed

Carvalhosa, A M; Henrard, S; Lambert, C; Hermans, C

2014-07-01

In Belgium, where haemophilia affects approximately 1:7000 people (2011), data on patients' quality of life (QoL) is scarce. This project aims to assess physical and mental QoL (P-QoL and M-QoL) simultaneously, and to analyse the influence of different variables on these two aspects of QoL. After Ethics Committee approval, we contacted 84 adult haemophilia A (HA) and haemophilia B (HB) patients, without current inhibitors, on replacement therapy (on-demand or secondary prophylaxis), regularly followed up at our comprehensive treatment centre. Seventy-one (n = 59 HA, n = 12 HB) replied to our questionnaire, which included the SF36v2 QoL assessment forms. We analysed two groups of variables: one including variables previously associated with decreased QoL, and another including variables with unclear impact on QoL (e.g., patients' understanding of haemophilia-related issues, economical concerns). In our population (mean ± SD age: 45.2 ± 14.7 years old), P-QoL appeared more reduced than M-QoL. P-QoL was strongly influenced by the number of arthropathies while M-QoL was primarily affected by patients' concern of personal costs due to haemophilia. Among this latter group, having knowledge of insurance coverage had a positive impact on M-QoL. Scores did not depend on haemophilia type. QoL was impaired in our haemophilia patients. A simultaneous assessment of P-QoL and M-QoL confirmed the benefit of primary prophylaxis in P-QoL, while originally pointing out the major burden of patients' concerns and poor understanding of haemophilia-related economical issues on their M-QoL. This might become a particularly challenging issue in times of financial crisis. © 2013 John Wiley & Sons Ltd.

The Effect of Sodium Hydroxide Molarity on Strength Development of Non-Cement Class C Fly Ash Geopolymer Mortar

NASA Astrophysics Data System (ADS)

Wardhono, A.

2018-01-01

The use of fly ash as cement replacement material can overcome the environmental issues, especially the global warming problem caused by the greenhouse effect. This is attributed to the CO2 gas produced during the cement manufacturing process, which 1 ton of cement is equivalent to 1 ton CO2. However, the major problem of fly ash is the requirement of activators to activate the polymer reactions. The most common activator used in non-cement or geopolymer material is the combination of sodium hydroxide (NaOH) and sodium silicate. This study aims to identify the effect of NaOH molarity as activator on strength development of non-cement class C fly ash geopolymer mortar. The molarity variations of NaOH were 6 Molar (M), 8M, 10M, 12M, 14M and 15M. The compressive strength test was performed at the age of 3, 7 and 28 days in accordance with ASTM standard, and the specimens were cured at room temperature. The results show that the highest compressive strength was achieved by geopolymer mortar with a molarity of 12M. It exhibits a higher strength to that normal mortar at 28 days. However, the use of NaOH molarity more than 12M tends to decrease the strength of non-cement geopolymer mortar specimens.

Prelimbic cortex extracellular signal-regulated kinase 1/2 activation is required for memory retrieval of long-term inhibitory avoidance.

PubMed

Luo, Fei; Zheng, Jian; Sun, Xuan; Deng, Wei-Ke; Li, Bao Ming; Liu, Fang

2017-04-15

Neural mechanism underlying memory retrieval has been extensively studied in the hippocampus and amygdala. However, little is known about the role of medial prefrontal cortex in long-term memory retrieval. We evaluate this issue in one-trial step-through inhibitory avoidance (IA) paradigm. Our results showed that, 1) inactivation of mPFC by local infusion of GABA A -receptor agonist muscimol caused severe deficits in retrieval of 1-day and 7-day but had no effects on 2-h inhibitory avoidance memory; 2) the protein level of phosphorylated-ERK1/2 in mPFC were significantly increased following retrieval of 1-day and 7-day IA memory, so did the numbers of phosphorylated-ERK (pERK) and phosphorylated-CREB (pCREB) labeled neurons; 3) intra-mPFC infusion of ERK kinase inhibitor PD98095 significantly reduced phosphorylated ERK1/2 levels and phosphorylated-ERK1/2 and phosphorylated-CREB labeled cells, and severely impaired retrieval of 7-day IA memory when the drugs were administrated 30min prior to test. The present study provides evidence that retrieval of long-lasting memory for inhibitory avoidance requires mPFC and involves the ERK-CREB signaling cascade. Copyright © 2017 Elsevier B.V. All rights reserved.

50 CFR 300.12 - Issuing offices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Issuing offices. 300.12 Section 300.12 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS High Seas Fisheries § 300.12 Issuing offices. Any Regional Administrator may issue permits required...

12 CFR Appendix M2 to Part 226 - Actual Repayment Disclosures

Code of Federal Regulations, 2010 CFR

2010-01-01

... Disclosures (a) Calculating actual repayment disclosures. (1) Definitions. (i) “Retail credit card” means a credit card that is issued by a retailer that can be used only in transactions with the retailer or a group of retailers that are related by common ownership or control, or a credit card where a retailer...

Development of 12 genic microsatellite loci for a biofuel grass, Miscanthus sinensis (Poaceae).

PubMed

Ho, Chuan-Wen; Wu, Tai-Han; Hsu, Tsai-Wen; Huang, Jao-Ching; Huang, Chi-Chun; Chiang, Tzen-Yuh

2011-08-01

Miscanthus, a nonfood plant with high potential as a biofuel, has been used in Europe and the United States. The selection of a cultivar with high biomass, photosynthetic efficiency, and stress resistance from wild populations has become an important issue. New genic microsatellite markers will aid the assessment of genetic diversity for different strains. Twelve polymorphic microsatellite markers derived from the transcriptome of Miscanthus sinensis fo. glaber were identified and screened on 80 individuals of M. sinensis. The number of alleles per locus ranged from 6 to 12, and the mean expected heterozygosity was 0.75. Cross-taxa transferability revealed that all loci can be applied to all varieties of M. sinensis, as well as the closely related species M. floridulus. These new genic microsatellite markers are useful for characterizing different traits in breeding programs or to select genes useful for biofuel.

Existence of a microRNA pathway in anucleate platelets

PubMed Central

Landry, Patricia; Plante, Isabelle; Ouellet, Dominique L; Perron, Marjorie P; Rousseau, Guy; Provost, Patrick

2010-01-01

Platelets play a critical role in the maintenance of hemostasis as well as in thrombosis and vessel occlusion that underlie stroke and acute coronary syndromes. Anucleate platelets contain messenger RNAs (mRNAs) and are capable of protein synthesis, raising the issue of how these mRNAs are regulated. Here we show that human platelets harbor an abundant and diverse array of microRNAs (miRNAs), which are known as key regulators of mRNA translation. Further analyses revealed that platelets contain Dicer and Argonaute 2 (Ago2) complexes functional in exogenously supplied miRNA precursor (pre-miRNA) processing and the control of specific reporter transcripts, respectively. Detection of the receptor P2Y12 mRNA in Ago2 immunoprecipitates suggests that P2Y12 expression may be subjected to miRNA control in human platelets. Our study lends an additional level of complexity to the control of gene expression in these anucleate elements of the cardiovascular system. PMID:19668211

Is The Real In Vivo Nitric Oxide Concentration Pico or Nano Molar? Influence of Electrode Size on Unstirred Layers and NO Consumption

PubMed Central

Bohlen, H. Glenn

2012-01-01

Objective There is a debate if the nitric oxide concentration ([NO]) required to influence vascular smooth muscle is below 50 nM or much higher. 30 μm and larger diameter electrodes report [NO] below 50 nM, whereas diameters of < 10–12 μm report hundreds of nM. This study examined how size of electrodes influenced [NO] measurement due to NO consumption and unstirred layer issues. Methods Electrodes were 2 mm disk, 30μm X 2 mm carbon fiber, and single 7μm diameter carbon fiber within open tip microelectrode, and exposed 7 μm carbon fiber of ~15 μm to 2 mm length. Results All electrodes demonstrated linear calibrations with sufficient stirring. As stirring slowed, 30 μm and 2 mm electrodes reported much lower [NO] due to unstirred layers and high NO consumption. The three 7 μm microelectrodes had minor stirring issues. With limited stirring with NO present, 7 μm open tip microelectrodes advanced toward 30 μm and 2 mm electrodes experienced dramatically decreased current within 10–50μm of the larger electrodes due to high NO consumption. None of the 7 μm microelectrodes interacted. Conclusions The data indicate large electrodes underestimate [NO] due to excessive NO consumption under conditions where unstirred layers are unavoidable and true microelectrodes are required for valid measurements. PMID:22925222

Persistent high-risk human papillomavirus (HPV) infections as surrogate endpoints of progressive cervical disease. Potential new endpoint for efficacy studies with new-generation (non-HPV 16/18) prophylactic HPV vaccines.

PubMed

Syrjänen, K

2011-01-01

Recent data indicate that persistent HR-HPV infections represent a significantly increased risk of developing incident high-grade CIN and cervical cancer. Accordingly, 6-month (6M+) or 12-month (12M+) type-specific persistence of HR-HPV have been proposed as powerful surrogates of progressive disease. Because of substantial practical impact in future HPV vaccine trials using non-HPV 16/18 vaccines, studies on HR-HPV persistence as a surrogate endpoint of progressive CIN have been subject to a comprehensive meta-analyses recently. The present communication was solicited to bring this important and timely topic to the awareness of the readers, in a format consisting of a review of the recent literature, supplemented with the author's own experience from different studies. Based on a large number of relevant studies, there remains little doubt that persistence of HR-HPV for 6+ or 12+ months is associated with a significantly increased risk of developing incident high-grade CIN. However, some data also disclosed several important issues that need to be carefully considered and/or adequately resolved before adopting 6M+ or 12M+ HR-HPV persistence as a surrogate of progressive disease. These include i) definitions of HPV persistence, ii) HPV detection techniques and iii) testing intervals and iv) length of follow-up, as well as v) diagnosis of the surrogate endpoints, and vi) other study characteristics, including vii) the type of reference category used in calculating the risk estimates. All these issues are critically discussed in the present communication. Of major impact seems to be the reference category used to calculate these risk estimates, as evident from the NIS-LAMS cohort. Taken together, it is suggested that in all future studies using the 6M+ or 12M+ HR-HPV persistence as a surrogate endpoint of progressive disease, a "gold standard" should be used in calculating the risk estimates. In addition to deciding, 1) whether to use 6M+ or 12M+ persistence criteria, and 2) cytological, histological or combined surrogate endpoints (SIL, CIN1, CIN2, CIN/SIL), one should 3) use exclusively the HPV negative reference group in calculating the risk estimates for viral persistence endpoints. This is supported by the data from the recent meta-analysis as well as from the author's combined NIS-LAMS cohort, both implicating that the most consistent association to progressive disease is obtained when women with persistent HR-HPV are compared with HPV-negative women. It is the conviction of this author that the two other reference categories (HPV transient and HPV mixed outcome) are far too heterogeneous and subject to potential misclassifications to give consistent and reproducible risk estimates for HR-HPV persistence as a surrogate endpoint of progressive CIN.

76 FR 63161 - Airworthiness Directives; Aviointeriors S.p.A. Passenger Seat 12M Series, Installed on But Not...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... of the United States Code specifies the FAA's authority to issue rules on aviation safety. Subtitle I... proposed actions to address it. Subject (d) Air Transport Association (ATA) of America Code 25: Equipment...,400--04013 Tor Tre Ponti, Italy; telephone 0039-0773- 689330 or 0039-0773-689291; fax 0039-0773-631546...

Mobilizing Learning: A Thematic Review of Apps in K-12 and Higher Education

ERIC Educational Resources Information Center

Stevenson, Michael Eric; Hedberg, John Gordon

2017-01-01

Purpose: This paper presents a thematic review of app-enabled learning in the context of recent developments in mobile technology and m-learning. Three key themes are presented that reflect the issues that teachers, school leaders and systems have grappled with in recent years. Design/Methodology/Approach: Drawing on findings from a range of case…

Interface Properties of Wide Bandgap Semiconductor Structures

DTIC Science & Technology

1994-06-01

resistive than silicides and their chemistry with 126I I Si-based materials more complex. However, in a series of studies, M. 0. Aboelfotoh et al. have...clarification of these issues. CuGe contacts on Ge:GaN and Mg:GaN. To date, the properties of Cu3Ge films have been documented by Aboelfotoh et al., but the...Martin, V. Malhotra, and J. E. Mahan, J. Vac. Sci. Technol. B 3, 836 (1985). 25. L. Krusin-Elbaum and M. 0. Aboelfotoh , Appl. Phys. Lett. 58(12), 1341

The issues in the development of a f = 162 . 5 MHz, β = 0 . 12 superconducting half-wave resonator for the Rare Isotope Science Project (RISP)

NASA Astrophysics Data System (ADS)

Park, Gunn Tae; Joo, Jongdae; Yao, Zhongyuan

2017-10-01

A f = 162 . 5 MHz superconducting half-wave resonator (HWR) with β = 0 . 12 is one of the four superconducting cavities being developed for the heavy ion linac of the Rare Isotope Science Project (RISP). The linac will accelerate various ions ranging from proton to uranium with beam power of about 400 kW. In particular, the HWR's will accelerate the ion beam in low-medium energy range, i.e., from 1.6 to 18 MeV for the case of uranium. In this paper, we describe design, fabrication, surface treatment, and vertical test of the 1st prototype of the cavity in detail. We also discuss some issues on the performance enhancement of the cavity. The Q0 values at 2 K surpassed the target performance, Q0 = 1 . 1 × 109 at Eacc = 6 . 3 MV / m.

[Mobile CT: technical aspects of prehospital stroke imaging before intravenous thrombolysis].

PubMed

Gierhake, D; Weber, J E; Villringer, K; Ebinger, M; Audebert, H J; Fiebach, J B

2013-01-01

To reduce the time from symptom onset to treatment with tissue plasminogen activator (tPA) in ischemic stroke, an ambulance was equipped with a CT scanner. We analyzed process and image quality of CT scanning during the pilot study regarding image quality and safety issues. The pilot study of a stroke emergency mobile unit (STEMO) ran over a period of 12 weeks on 5 weekdays from 7a.m. to 6:30 p.m. A teleradiological service for the justifying indication and reporting was established. The radiographer was responsible for the performance of the CT scan on the ambulance. 64 cranial CT scans and 1 intracranial CT angiography were performed. We compared times from ambulance alarm to treatment decision (time of last brain scan) with a cohort of 50 consecutive tPA treatments before implementation of STEMO. 62 (95%) of the 65 scans performed had sufficient quality for reading. Technical quality was not optimal in 45 cases (69%) mainly caused by suboptimal positioning of patient or eye lens protection. Motion artefacts were observed in 8 exams (12%). No safety issues occurred for team or patients. 23 patients were treated with thrombolysis. Time from alarm to last CT scan was 18 minutes shorter than in the tPA cohort before STEMO implementation. A teleradiological support for primary stroke imaging by CT on-site is feasible, quality-wise of diagnostic value and has not raised safety issues. © Georg Thieme Verlag KG Stuttgart · New York.

Telephone Problem-Solving Treatment Improves Sleep Quality in Service Members With Combat-Related Mild Traumatic Brain Injury: Results From a Randomized Clinical Trial.

PubMed

Vuletic, S; Bell, K R; Jain, S; Bush, N; Temkin, N; Fann, J R; Stanfill, K E; Dikmen, S; Brockway, J A; He, F; Ernstrom, K; Raman, R; Grant, G; Stein, M B; Gahm, G A

2016-01-01

Evaluate sleep quality, its correlates, and the effect of telephone-based problem-solving treatment (PST) in active duty postdeployment service members with mild traumatic brain injury (mTBI) SETTING:: Randomized clinical trial. Active duty service members with combat-related mTBI. Education-only (EO) and PST groups (N = 178 each) received printed study materials and 12 educational brochures. The PST group additionally received up to 12 PST telephone calls addressing participant-selected issues. Outcomes were evaluated postintervention (6 months) and at 12 months. Pittsburgh Sleep Quality Index. Sleep quality was manifestly poor in both groups at baseline (Pittsburgh Sleep Quality Index = 12.5 ± 4). Overall sleep quality was significantly different between the PST and EO groups at 6 months (P = .003) but not at 12 months. Longitudinally, PST significantly improved sleep quality at 6 months (P = .001) but not over the follow-up. Low sleep quality was associated with concussion symptoms, pain, depression, and posttraumatic stress disorder at all time points (P < .0001). Sleep disorders, common in postdeployment service members with mTBI, are strongly associated with the presence of pain, posttraumatic stress disorder, and depression. Telephone-based PST may be an effective therapeutic approach for reducing sleep disorders in this population. Research should focus on maintenance of treatment gains.

17 CFR 240.3a12-10 - Exemption of certain securities issued by the Resolution Funding Corporation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... securities issued by the Resolution Funding Corporation. 240.3a12-10 Section 240.3a12-10 Commodity and... Exemptions § 240.3a12-10 Exemption of certain securities issued by the Resolution Funding Corporation. Securities that are issued by the Resolution Funding Corporation pursuant to section 21B(f) of the Federal...

Understanding Quality Issues in Your Surgical Department: Comparing the ACS NSQIP With Traditional Morbidity and Mortality Conferences in a Canadian Academic Hospital.

PubMed

Auspitz, Mark; Cleghorn, Michelle C; Tse, Alvina; Sockalingam, Sanjeev; Quereshy, Fayez A; Okrainec, Allan; Jackson, Timothy D

2015-01-01

Review of surgical complications in traditional morbidity and mortality (M&M) rounds remains an important mechanism to identify and discuss quality-of-care issues. This process relies on case selection by providers; therefore, complications identified for review may differ from those captured in comprehensive quality programs such as the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP). Additionally, although the ACS NSQIP captures robust data on complications in surgical wards, without strategies to disseminate this information to staff and improve practice, minimal change may result. The objective of this study was to compare complications identified by the ACS NSQIP with those captured in M&M conferences at a large Canadian academic hospital. Retrospective medical record reviews of all patients admitted to the general surgery unit from March 2012 to March 2013 were reviewed. Number and types of complications were recorded for cases that were both submitted and reviewed in M&M rounds and those cases that were submitted but not reviewed. These complications were compared with those extracted from our local ACS NSQIP database. A total of 1348 general surgical procedures were performed. The ACS NSQIP captured complications in 143 patients compared with 58 patients identified for review in M&M rounds. Both the methods identified similar proportions of major and minor complications (ACS NSQIP 52% major, 48% minor; M&M 58% major, 42% minor). More postoperative deaths were entered into the ACS NSQIP (12) than in M&M conferences (8 reviewed and 2 submitted). The ACS NSQIP identified higher proportions of surgical site infections and readmissions. However, M&M conferences captured additional complications in patients who did not undergo surgery and identified potential quality issues in patients who did not ultimately experience an adverse outcome. M&M rounds and the ACS NSQIP provide important and potentially complementary data on surgical quality. Incorporating the ACS NSQIP outcomes data into traditional M&M conferences may help to optimize quality improvement efforts. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

36 CFR 72.12 - Assessment of needs, problems and issues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and issues. 72.12 Section 72.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT... Assessment of needs, problems and issues. The Action Program should begin with an Assessment describing the existing park and recreation system; issues and problems; goals and objectives. The Assessment should...

36 CFR 72.12 - Assessment of needs, problems and issues.

Code of Federal Regulations, 2012 CFR

2012-07-01

... and issues. 72.12 Section 72.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT... Assessment of needs, problems and issues. The Action Program should begin with an Assessment describing the existing park and recreation system; issues and problems; goals and objectives. The Assessment should...

36 CFR 72.12 - Assessment of needs, problems and issues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... and issues. 72.12 Section 72.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT... Assessment of needs, problems and issues. The Action Program should begin with an Assessment describing the existing park and recreation system; issues and problems; goals and objectives. The Assessment should...

36 CFR 72.12 - Assessment of needs, problems and issues.

Code of Federal Regulations, 2014 CFR

2014-07-01

... and issues. 72.12 Section 72.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT... Assessment of needs, problems and issues. The Action Program should begin with an Assessment describing the existing park and recreation system; issues and problems; goals and objectives. The Assessment should...

Role of Public Outreach in the University Science Mission: Publishing K-12 Curriculum, Organizing Tours, and Other Methods of Engagement

NASA Astrophysics Data System (ADS)

Dittrich, T. M.

2015-12-01

Much attention has been devoted in recent years to the importance of Science, Technology, Engineering, and Math (STEM) education in K-12 curriculum for developing a capable workforce. Equally important is the role of the voting public in understanding STEM-related issues that impact public policy debates such as the potential impacts of climate change, hydraulic fracturing in oil and gas exploration, mining impacts on water quality, and science funding. Since voted officials have a major impact on the future of these policies, it is imperative that the general public have an understanding of the basic science behind these issues. By engaging with the public in a more fundamental way, university students can play an important role in educating the public while at the same time enhancing their communication skills and gaining valuable teaching experience. I will talk about my own experiences in (1) evaluating and publishing water chemistry and hazardous waste cleanup curriculum on the K-12 engineering platform TeachEngineering.org, (2) organizing public tours of water and energy sites (e.g., abandoned mine sites, coal power plants, wastewater treatment plants, hazardous waste treatment facilities), and (3) other outreach and communication activities including public education of environmental issues through consultations with customers of a landscaping/lawn mowing company. The main focus of this presentation will be the role that graduate students can play in engaging and educating their local community and lessons learned from community projects (Dittrich, 2014; 2012; 2011). References: Dittrich, T.M. 2014. Adventures in STEM: Lessons in water chemistry from elementary school to graduate school. Abstract ED13E-07 presented at 2014 Fall Meeting, AGU, San Francisco, Calif., 15-19 Dec. Dittrich, T.M. 2012. Collaboration between environmental water chemistry students and hazardous waste treatment specialists on the University of Colorado-Boulder campus. Abstract ED53C-0932 presented at 2012 Fall Meeting, AGU, San Francisco, Calif., 3-7 Dec. Dittrich, T.M. 2011. Taking advantage of STEM (science, technology, engineering, and math) popularity to enhance student/public engagement. Abstract ED44A-03 presented at 2011 Fall Meeting, AGU, San Francisco, Calif., 5-9 Dec.

Multi-Dimensional Measurement of Antibody-Mediated Heterosubtypic Immunity to Influenza.

PubMed

Wang, Jiong; Hilchey, Shannon P; Hyrien, Ollivier; Huertas, Nelson; Perry, Sheldon; Ramanunninair, Manojkumar; Bucher, Doris; Zand, Martin S

2015-01-01

The human immune response to influenza vaccination depends in part on preexisting cross-reactive (heterosubtypic) immunity from previous infection by, and/or vaccination with, influenza strains that share antigenic determinants with the vaccine strains. However, current methods for assessing heterosubtypic antibody responses against influenza, including the hemagglutination-inhibition (HAI) assay and ELISA, are time and labor intensive, and require moderate amounts of serum and reagents. To address these issues we have developed a fluorescent multiplex assay, mPlex-Flu, that rapidly and simultaneously measures strain specific IgG, IgA, and IgM antibodies against influenza hemagglutinin (HA) from multiple viral strains. We cloned, expressed and purified HA proteins from 12 influenza strains, and coupled them to multiplex beads. Assay validation showed that minimal sample volumes (<5 μl of serum) were needed, and the assay had a linear response over a four Log10 range. The assay detected nanogram levels of anti-influenza specific antibodies, had high accuracy and reproducibility, with an average percentage coefficient of variation (%CV) of 9.06 for intra-assay and 12.94 for inter-assay variability. Pre- and post-intramuscular trivalent influenza vaccination levels of virus specific Ig were consistent with HAI titer and ELISA measurements. A significant advantage of the mPLEX-Flu assay over the HAI assay is the ability to perform antigenic cartography, determining the antigenic distances between influenza HA's, without mathematical correction for HAI data issues. For validation we performed antigenic cartography on 14 different post-influenza infection ferret sera assayed against 12 different influenza HA's. Results were in good agreement with a phylogenetic tree generated from hierarchical clustering of the genomic HA sequences. This is the first report of the use of a multiplex method for antigenic cartography using ferret sera. Overall, the mPlex-Flu assay provides a powerful tool to rapidly assess the influenza antibody repertoire in large populations and to study heterosubtypic immunity induced by influenza vaccination.

Multi-Dimensional Measurement of Antibody-Mediated Heterosubtypic Immunity to Influenza

PubMed Central

Wang, Jiong; Hilchey, Shannon P.; Hyrien, Ollivier; Huertas, Nelson; Perry, Sheldon; Ramanunninair, Manojkumar; Bucher, Doris; Zand, Martin S.

2015-01-01

The human immune response to influenza vaccination depends in part on preexisting cross-reactive (heterosubtypic) immunity from previous infection by, and/or vaccination with, influenza strains that share antigenic determinants with the vaccine strains. However, current methods for assessing heterosubtypic antibody responses against influenza, including the hemagglutination-inhibition (HAI) assay and ELISA, are time and labor intensive, and require moderate amounts of serum and reagents. To address these issues we have developed a fluorescent multiplex assay, mPlex-Flu, that rapidly and simultaneously measures strain specific IgG, IgA, and IgM antibodies against influenza hemagglutinin (HA) from multiple viral strains. We cloned, expressed and purified HA proteins from 12 influenza strains, and coupled them to multiplex beads. Assay validation showed that minimal sample volumes (<5 μl of serum) were needed, and the assay had a linear response over a four Log10 range. The assay detected nanogram levels of anti-influenza specific antibodies, had high accuracy and reproducibility, with an average percentage coefficient of variation (%CV) of 9.06 for intra-assay and 12.94 for inter-assay variability. Pre- and post-intramuscular trivalent influenza vaccination levels of virus specific Ig were consistent with HAI titer and ELISA measurements. A significant advantage of the mPLEX-Flu assay over the HAI assay is the ability to perform antigenic cartography, determining the antigenic distances between influenza HA’s, without mathematical correction for HAI data issues. For validation we performed antigenic cartography on 14 different post-influenza infection ferret sera assayed against 12 different influenza HA’s. Results were in good agreement with a phylogenetic tree generated from hierarchical clustering of the genomic HA sequences. This is the first report of the use of a multiplex method for antigenic cartography using ferret sera. Overall, the mPlex-Flu assay provides a powerful tool to rapidly assess the influenza antibody repertoire in large populations and to study heterosubtypic immunity induced by influenza vaccination. PMID:26103163

Antimalarial pyrido[1,2-a]benzimidazoles.

PubMed

Ndakala, Albert J; Gessner, Richard K; Gitari, Patricia W; October, Natasha; White, Karen L; Hudson, Alan; Fakorede, Foluke; Shackleford, David M; Kaiser, Marcel; Yeates, Clive; Charman, Susan A; Chibale, Kelly

2011-07-14

A novel class of antimalarial pyrido[1,2-a]benzimidazoles were synthesized and evaluated for antiplasmodial activity and cytotoxicity following hits identified from screening commercially available compound collections. The most active of these, TDR86919 (4c), showed improved in vitro activity vs the drug-resistant K1 strain of Plasmodium falciparum relative to chloroquine (IC(50) = 0.047 μM v 0.17 μM); potency was retained against a range of drug-sensitive and drug-resistant strains, with negligible cytotoxicity against the mammalian (L-6) cell line (selectivity index of >600). 4c and several close analogues (as HCl or mesylate salts) showed significant efficacy in P. berghei infected mice following both intraperitoneal (ip) and oral (po) administration, with >90% inhibition of parasitemia, accompanied by an increase in the mean survival time (MSD). The pyrido[1,2-a]benzimidazoles appeared to be relatively slow acting in vivo compared to chloroquine, and metabolic stability of the alkylamino side chain was identified as a key issue in influencing in vivo activity.

Improved Gas Metal Arc Welding Multi-Physics Process Model and Its Application to MIL A46100 Armor-Grade Steel Butt-welds

DTIC Science & Technology

2014-01-01

expansion a 1/K 11e–6-12e–6 Specific heat C p J/kg K 440-520 Thermal conductivity k W/m K 35-50 Heat transfer coefficient h W/m2 K 45 Sink temperature...filler-metal consumable electrode to the weld; third, prediction of the temporal evolution and the spatial distribution of thermal and mechanical...the thermal The current issue and full text archive of this journal is available at www.emeraldinsight.com/1573-6105.htm Received 20 May 2013 Revised 13

Lackland Air Force Base Phase II Uniform Issue: Baseline Report

DTIC Science & Technology

2011-05-01

Lectures on uniform wearing and care are given 1-2 ORGANIZATION The remainder of this report includes two...sp ec ts al te ra tio ns A pp ro ve d to U S A F sp ec ? Tr ai ne es p ac k ite m s in d uf fle Y es A ll ite m s in sp ec te d? In ve nt...First alteration Second alteration Third alteration Pe rc en ta ge o f t ro us er s al te re d 0% 10% 20% 30% 40% 50% 60% 70% 80%

Naval Sea Systems Command Did Not Properly Apply Guidance Regarding Contracting Officers Representatives

DTIC Science & Technology

2016-03-18

Contract _______________________________ 10 PCO and ACO Did Not Ensure Appointment of COR ________________________________________ 12 NAVSEA Did Not Properly...sample was selected, NAVSEA had issued work for 36 availabilities on the contract—obligating $102.5M. { The procuring contracting officer ( PCO ) at...Responsibilities,” Section 1.602-2, “Responsibilities,” May 29, 2014. 3 The contracting officers for the contract reviewed are the PCO at NAVSEA

Are Gains in Decision-Making Autonomy during Early Adolescence Beneficial for Emotional Functioning? The Case of the United States and China

ERIC Educational Resources Information Center

Qin, Lili; Pomerantz, Eva M.; Wang, Qian

2009-01-01

This research examined the role of children's decision-making autonomy in their emotional functioning during early adolescence in the United States and China. Four times over the 7th and 8th grades, 825 American and Chinese children (M = 12.73 years) reported on the extent to which they versus their parents make decisions about issues children…

Discovery of a Bow Shock around VELA X-1: Erratum

NASA Astrophysics Data System (ADS)

Kaper, L.; van Loon, J. Th.; Augusteijn, T.; Goudfrooij, P.; Patat, F.; Waters, L. B. F. M.; Zijlstra, A. A.

1997-04-01

In the Letter Discovery of a Bow Shock around Vela X-1 by L. Kaper, J. Th. van Loon, T. Augusteijn, P. Goudfrooij, F. Patat, L. B. F. M. Waters, and A. A. Zijlstra (ApJ, 475, L37 [1997]), Figure 1 (Plate L7) was printed without its axis labels, as the result of a printer's error. The corrected figure appears in this issue as Plate L12.

Gas generation behavior of transuranic waste under disposal conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fujisawa, Ryutaro; Kurashige, Tetsunari; Inagaki, Yusuke

1999-07-01

The generation of hydrogen-gas from metallic waste is an important issue for the safety analysis of geological disposal facilities for transuranic (TRU) radioactive waste in Japan. The objective of this study is to clarify the gas-generation behavior of stainless steel and carbon steel in non-oxidizing alkaline synthetic groundwater (pH 12.8 and 10.5) at 30 C simulating geological disposal environments. At pH 12.8, the observed gas-generation rate from stainless steel in the initial period of immersion was 1.0 x 10{sup 2} Nml/m{sup 2}/y and 1.0 x 10 Nml/m{sup 2}/y after 200 days (N represents the standard state of gas at 0more » C and 1 atm). At pH 10.5, gas generation was not observed for 60 days in the initial period. At 60 days, the gas-generation observed was 5.0 x 10 NMl/m{sup 2}/y. After 250 days, the gas-generation rate approaches zero. At pH 12.8, the observed gas generation rate of carbon steel in the initial period of immersion was 1.5 x 10{sup 2} Nml/m{sup 2}/y and the gas generation rate began to decrease after 200 days. After 300 days, it was 25 Nml/m{sup 2}/y. At pH 10.5, the gas generation rate in the initial period was 5.0 x 10{sup 2} Nml/m{sup 2}/y and was 1.0 x 10 Nml/m{sup 2}/y after 200 days.« less

Complete automation of solid-phase extraction with subsequent liquid chromatography-tandem mass spectrometry for the quantification of benzoylecgonine, m-hydroxybenzoylecgonine, p-hydroxybenzoylecgonine, and norbenzoylecgonine in urine--application to a high-throughput urine analysis laboratory.

PubMed

Robandt, Paul P; Reda, Louis J; Klette, Kevin L

2008-10-01

A fully automated system utilizing a liquid handler and an online solid-phase extraction (SPE) device coupled with liquid chromatography-tandem mass spectrometry (LC-MS-MS) was designed to process, detect, and quantify benzoylecgonine (BZE), meta-hydroxybenzoylecgonine (m-OH BZE), para-hydroxybenzoylecgonine (p-OH BZE), and norbenzoylecgonine (nor-BZE) metabolites in human urine. The method was linear for BZE, m-OH BZE, and p-OH BZE from 1.2 to 10,000 ng/mL with limits of detection (LOD) and quantification (LOQ) of 1.2 ng/mL. Nor-BZE was linear from 5 to 10,000 ng/mL with an LOD and LOQ of 1.2 and 5 ng/mL, respectively. The intrarun precision measured as the coefficient of variation of 10 replicates of a 100 ng/mL control was less than 2.6%, and the interrun precision for 5 replicates of the same control across 8 batches was less than 4.8% for all analytes. No assay interference was noted from controls containing cocaine, cocaethylene, and ecgonine methyl ester. Excellent data concordance (R2 > 0.994) was found for direct comparison of the automated SPE-LC-MS-MS procedure and an existing gas chromatography-MS procedure using 94 human urine samples previously determined to be positive for BZE. The automated specimen handling and SPE procedure, when compared to the traditional extraction schema, eliminates the human factors of specimen handling, processing, extraction, and derivatization, thereby reducing labor costs and rework resulting from batch handling issues, and may reduce the number of fume hoods required in the laboratory.

Apollo Video Photogrammetry Estimation of Plume Impingement Effects

NASA Technical Reports Server (NTRS)

Immer, Christopher; Lane, John; Metzger, Philip; Clements, Sandra

2008-01-01

Each of the six Apollo mission landers touched down at unique sites on the lunar surface. Aside from the Apollo 12 landing site located 180 meters from the Surveyor III lander, plume impingement effects on ground hardware during the landings were largely not an issue. The Constellation Project's planned return to the moon requires numerous landings at the same site. Since the top few centimeters are loosely packed regolith, plume impingement from the lander ejects the granular material at high velocities. With high vacuum conditions on the moon (10 (exp -14) to 10 (epx -12) torr), motion of all particles is completely ballistic. Estimates from damage to the Surveyor III show that the ejected regolith particles to be anywhere 400 m/s to 2500 m/s. It is imperative to understand the physics of plume impingement to safely design landing sites for the Constellation Program.

Social Studies Review, Numbers 1-12, 1989-1992.

ERIC Educational Resources Information Center

Sewall, Gilbert T., Ed.

1992-01-01

This documents consists of 12 issues of a journal that seeks to provide information and reviews concerning social studies textbooks; each issue consists of 16 pages. Contents in the 12 issues include: (1) California control over textbook content; (2) "skills" teaching in elementary-level social studies texts; (3) readability formulas;…

Practical Issues in Having a Usable Library of Software Specifications.

DTIC Science & Technology

1981-03-01

Specifications* DEC 1 5 1981 Ralph M. Weischedel H Department of Computer & Information Sciences University of Delaware Newark, DE 19711 *Research sponsored by...AREA 6 WORK UNIT NUMBERS University of Delaware I Newark, DE 19711 61102F 2304/A2 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE Air Force...Irom Controlling Office) 15. SECURITY CLASS. (of this report) UNCLASSIFIED ISa. DECLASSIFICATION/DOWNGRADING SCHEDu LE 16. DISTRIBUTION STATEMENT (of

Indications and Warning Analysis Management System IWAMS. A Design Study

DTIC Science & Technology

1980-03-01

First, we must understand the process of warning analysis; we must develop an -;adequate functional model. In the present research we have divided ...and changeable). (In subsequent discussions, considerable attention will be focused on these issues.) -77-7-12Z ’m,77+-U 21 WARNING ANALYSIS MODEL...have charted limitations in man’s memory, attention span, reasoning capability and other cognitive functions. These limitations considerably affect man’s

Effects of Nonequilibrium Plasmas on Eukaryotic Cells

DTIC Science & Technology

2009-05-01

medical applications, such as the removal of dead tissue and the acceleration of wound healing. These "plasma-induced" bioeffects are therefore of... blood coagulation device. Unfortunately, due to various issues related to experimenting with blood in our lab, we were unable to conduct this...species with flagella) and viability, 1 mL of algal culture was added into a well of a 12-well culture plate ( liquid depth in the well 5 mm), the

Sustaining growth and profitability--The Economist fifth annual pharmaceuticals conference. 12-13 November 1998, London, UK.

PubMed

Muhsin, M

1999-01-01

This two-day conference, organized by The Economist, focused on R and D productivity, strategic and innovative methodologies, M and A activities and knowledge management within the pharmaceutical industry. Key speakers within the industry addressed these issues to an audience of approximately 100 healthcare business executives. The first day was chaired by Barrie Haigh (Quintiles Translational Corp) and the second day by Tobias Rooney (Gemini Consulting).

12 CFR 16.8 - Small issues.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Small issues. 16.8 Section 16.8 Banks and....8 Small issues. (a) The OCC will deem offers and sales of bank issued securities that satisfy the requirements of Commission Regulation A (17 CFR part 230, Regulation A—Conditional Small Issues Exemption) to...

Facile Synthesis of Platelike Hierarchical Li1.2Mn0.54Ni0.13Co0.13O2 with Exposed {010} Planes for High-Rate and Long Cycling-Stable Lithium Ion Batteries.

PubMed

Zeng, Jiong; Cui, Yanhui; Qu, Deyang; Zhang, Qian; Wu, Junwei; Zhu, Xiaomeng; Li, Zuohua; Zhang, Xinhe

2016-10-05

Lithium-rich layered oxides are promising cathode candidates for the production of high-energy and high-power electronic devices with high specific capacity and high discharge voltage. However, unstable cycling performance, especially at high charge-recharge rate, is the most challenge issue which needs to be solved to foster the diffusion of these materials. In this paper, hierarchical platelike Li 1.2 Mn 0.54 Ni 0.13 Co 0.13 O 2 cathode materials were synthesized by a facile solvothermal method followed by calcination. Calcination time was found to be a key parameter to obtain pure layered oxide phase and tailor its hierarchical morphology. The Li-rich material consists of primary nanoparticles with exposed {010} planes assembled to form platelike layers which exhibit low resistance to Li + diffusion. In detail, the product by calcination at 900 °C for 12 h exhibits specific capacity of 228, 218, and 204 mA h g -1 at 200, 400, and 1000 mA g -1 , respectively, whereas after 100 cycles at 1000 mA g -1 rate of charge and recharge the specific capacity was retained by about 91%.

Flame Propagation and Blowout in Hydrocarbon Jets: Experiments to Understand the Stability and Structure

DTIC Science & Technology

2012-07-29

Wilson and Kevin M. Lyons. On Diluted-Fuel Combustion Issues in Burning Biogas Surrogates, ASME-JERT, (12 2009): . doi: 2010/01/07 10:47:38 2 TOTAL...four coflow velocities are used, resulting in eight additional flow configurations. Table 2 contains the data obtained for these configurations, as...counterflow have higher stability limits than those in an oblique configuration. 4.) Conclusions Based on the results obtained from this experiment, a

ERDC-CERL LD-870 Download Program Developed for Aberdeen Test Center: User’s Manual

DTIC Science & Technology

2007-05-01

Conexant 56k internal modem , supplied by Dell, different Rockwell chipset The current modem string is: AT&F X4 E0 Q0 V1 T M0 W2 S0=5 S12=0 &D2 &W...noise monitors. It provides a trouble- shooting guide for resolving known issues with the monitoring system and contains information regarding modem ...20 Unit is dialed, modem responds with “No Carrier

The Role of the Department of State in the Foreign Policy Decision-Making Process

DTIC Science & Technology

1987-02-01

continually hone his issues, chaos in~ wisely ~mong the 12 options, developing a relatively coherent set of policies, communicating them, persuading...the President to develop and imp]e;L~.er:~:, a sound foreign policy strategy for the United States. ill BIOGRAPfIICAL SKETCH Dorothy M. Sampas...business overseas and development of more U.o. < markets overseas -- in 1979, to the Department of Commerce.. --The loss of policy guidance for U e

Four-electron transfer tandem tetracyanoquinodimethane for cathode-active material in lithium secondary battery

NASA Astrophysics Data System (ADS)

Kurimoto, Naoya; Omoda, Ryo; Mizumo, Tomonobu; Ito, Seitaro; Aihara, Yuichi; Itoh, Takahito

2018-02-01

Quinoid compounds are important candidates of organic active materials for lithium-ion batteries. However, its high solubility to organic electrolyte solutions and low redox potential are known as their major drawbacks. To circumvent these issues, we have designed and synthesized a tandem-tetracyanoquinonedimethane type cathode-active material, 11,11,12,12,13,13,14,14-octacyano-1,4,5,8-anthradiquinotetramethane (OCNAQ), that has four redox sites per molecule, high redox potential and suppressed solubility to electrolyte solution. Synthesized OCNAQ has been found to have two-step redox reactions by cyclic voltammetry, and each step consists of two-electron reactions. During charge-discharge tests using selected organic cathode-active materials with a lithium metal anode, the cell voltages obtained from OCNAQ are higher than those for 11,11-dicyanoanthraquinone methide (AQM) as expected, due to the strong electron-withdrawing effect of the cyano groups. Unfortunately, even with the use of the organic active material, the issue of dissolution to the electrolyte solution cannot be suppressed completely; however, appropriate choice of the electrolyte solutions, glyme-based electrolyte solutions in this study, give considerable improvement of the cycle retention (98% and 56% at 10 and 100 cycles at 0.5C, respectively). The specific capacity and energy density obtained in this study are 206 mAh g-1 and 554 mWh g-1 with respect to the cathode active material.

Phytochemicals in Food and Nutrition.

PubMed

Xiao, Jianbo

2016-07-29

The International Symposium on Phytochemicals in Medicine and Food (ISPMF2015) was held from June 26 to 29, 2015, in Shanghai, China. It is for the first time that a Phytochemical Society of Europe conference took place in China, which provided an opportunity for 270 scientists from 48 countries to communicate their up-to-date knowledge on phytochemicals. ISPMF2015 comprised exciting and various programs with 16 sessions, including 12 plenary lectures, 20 invited talks, 55 short oral presentations, and more than 130 posters. With the help of Prof. Fergus M. Clydesdale, a special issue of Critical Reviews in Food Science and Nutrition containing 11 reviews from scientists was presented in this conference. In this special issue, bioactive flavonoids and polysaccharides for human health received significant attention.

12 CFR 559.12 - How may a subsidiary of a savings association issue securities?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false How may a subsidiary of a savings association issue securities? 559.12 Section 559.12 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SUBORDINATE ORGANIZATIONS Regulations Applicable to All Savings Associations § 559.12 How...

The Built Environment Is a Microbial Wasteland

PubMed Central

2016-01-01

ABSTRACT Humanity’s transition from the outdoor environment to the built environment (BE) has reduced our exposure to microbial diversity. The relative importance of factors that contribute to the composition of human-dominated BE microbial communities remains largely unknown. In their article in this issue, Chase and colleagues (J. Chase, J. Fouquier, M. Zare, D. L. Sonderegger, R. Knight, S. T. Kelley, J. Siegel, and J. G. Caporaso, mSystems 1(2):e00022-16, 2016, http://dx.doi.org/10.1128/mSystems.00022-16) present an office building study in which they controlled for environmental factors, geography, surface material, sampling location, and human interaction type. They found that surface location and geography were the strongest factors contributing to microbial community structure, while surface material had little effect. Even in the absence of direct human interaction, BE surfaces were composed of 25 to 30% human skin-associated taxa. The authors demonstrate how technical variation across sequencing runs is a major issue, especially in BE work, where the biomass is often low and the potential for PCR contaminants is high. Overall, the authors conclude that BE surfaces are desert-like environments where microbes passively accumulate. PMID:27832216

77 FR 15751 - Meetings of the Local Government Advisory Committee and the Small Communities Advisory Subcommittee

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

...The Small Communities Advisory Subcommittee (SCAS) will meet via teleconference on Tuesday, March 27, 2012, 2 p.m.-3 p.m. (ET), and the SCAS will meet at EPA's Region 8 office in Denver, CO, on Thursday, April 18, 2012, 3 p.m.-5 p.m. (MT). The Subcommittee will discuss decentralized wastewater treatment and other issues and recommendations to the Administrator regarding environmental issues affecting small communities. These are open meetings, and all interested persons are invited to participate. The Subcommittee will hear comments from the public during the teleconference on Tuesday, March 27, 2012 between 2:50 p.m. and 3 p.m. (ET) and during the meeting on Thursday, April 18, 2012 between 4:45 p.m. and 5 p.m. (MT). Individuals or organizations wishing to address the Subcommittee will be allowed a maximum of five minutes to present their point of view. Also, written comments should be submitted electronically to [email protected] Please contact the Designated Federal Officer (DFO) at the number listed below to schedule a time on the agenda. Time will be allotted on a first-come first-serve basis, and the total period for comments may be extended if the number of requests for appearances requires it. The Local Government Advisory Committee (LGAC) will meet at EPA's Region 8 office in Denver, CO, on Thursday, April 19, 2012, 10 a.m.- 4:15 p.m. (MT), and Friday, April 20, 2012, 9 a.m.-12 p.m. (MT). The Committee will discuss integrated water quality planning, hydraulic fracturing, air quality issues and environmental justice and Title VI. This is an open meeting and all interested persons are invited to participate. The Committee will hear comments from the public between 4 p.m.-4:15 p.m. (MT) on Thursday, April 19, 2012. Individuals or organizations wishing to address the Committee will be allowed a maximum of five minutes to present their point of view. Also, written comments should be submitted electronically to [email protected] Please contact the Designated Federal Officer (DFO) at the number listed below to schedule a time on the agenda. Time will be allotted on a first-come first-serve basis, and the total period for comments may be extended if the number of requests for appearances requires it.

Initiation of primary cell culture from amphioxus Branchiostoma belcheri tsingtauense

NASA Astrophysics Data System (ADS)

Wang, Changliu; Zhang, Shicui; Su, Feng; Wang, Lei; Li, Hongyan

2009-02-01

Amphioxus, a cephalochordate, is an important model fish for studies in evolution and comparative biology. A successful cell culture from amphioxus tissues in vitro would help understanding some basic issues. To determine the optimal culture conditions for proliferation of amphioxus cells, primary cultures were initiated from buccal cirri, tail, gill, gut and metapleural fold of amphioxus Branchiostoma belcheri tsingtauense. The media tested were L-15, F-12, M 199, MEM, DMEM, PRMI 1640 and LDF, each was supplemented with 20% fetal bovine serum. The optimal conditions include tail tissue cultured in L-15 or F-12 with supplement of 20% FBS and 1.5% NaCl at about 25°C.

12 CFR 810.0 - Authority for issue and sale.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Authority for issue and sale. 810.0 Section 810.0 Banks and Banking FEDERAL FINANCING BANK FEDERAL FINANCING BANK BILLS § 810.0 Authority for issue... issue publicly, with the approval of the Secretary of the Treasury, obligations having such maturities...

12 CFR 615.5100 - Authority to issue.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Authority to issue. 615.5100 Section 615.5100... Obligations § 615.5100 Authority to issue. The Act authorizes each bank of the System, subject to the collateral requirements of section 4.3(c) of the Act, to issue: (a) Notes, bonds, debentures, or other...

Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells.

PubMed

Huang, Jia; Xiao, Lan; Wei, Jing-Xiang; Shu, Ya-Hai; Fang, Shi-Qi; Wang, Yong-Tang; Lu, Xiu-Min

2017-04-01

As a neurotropic substance, ethanol can damage nerve cells through an increase in the production of free radicals, interference of neurotrophic factor signaling pathways, activation of endogenous apoptotic signals and other molecular mechanisms. Previous studies have revealed that a number of natural drugs extracted from plants offer protection of nerve cells from damage. Among these, arctigenin (ATG) is a lignine extracted from Arctium lappa (L.), which has been found to exert a neuroprotective effect on scopolamine‑induced memory deficits in mice with Alzheimer's disease and glutamate-induced neurotoxicity in primary neurons. As a result, it may offer beneficial effects on ethanol-induced neurotoxicity. However, the effects of ATG on ethanol‑induced nerve damage remain to be elucidated. To address this issue, the present study used rat pheochromocytoma PC12 cells to investigate the neuroprotective effects of ATG on ethanol-induced cell damage by performing an MTT reduction assay, cell cycle analysis, Hoechst33342/propidium iodide fluorescence staining and flow cytometry to examine apoptosis. The results showed that 10 µM ATG effectively promoted the proliferation of damaged cells, and increased the distribution ratio of the cells at the G2/M and S phases (P<0.05). In addition, the apoptosis and necrosis of the PC12 cells were significantly decreased following treatment with ATG. Therefore, it was concluded that 10 µM ATG had a protective effect on ethanol‑induced injury in PC12 cells.

12 CFR 1204.1 - Why did FHFA issue this part?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Why did FHFA issue this part? 1204.1 Section 1204.1 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS PRIVACY ACT IMPLEMENTATION § 1204.1 Why did FHFA issue this part? FHFA issued this part to: (a) Implement the Privacy Act of...

Criminal Protection Orders for Women Victims of Domestic Violence: Explicating Predictors of Level of Restrictions Among Orders Issued.

PubMed

Sullivan, Tami P; Weiss, Nicole H; Price, Carolina; Pugh, Nicole E

2017-10-01

Criminal protection orders (POs), with varying degrees of restrictions, are issued by the criminal justice system to enhance the safety of victims of domestic violence (DV). Limited research exists to elucidate factors associated with their issuance. Therefore, the purpose of this study was to investigate how demographic, relationship, parenting, and court-process-related factors are related to the level of restriction the PO places on the offender. Two-hundred ninety-eight women who were victims in a criminal DV case ( M age 36.4, 50.0% African American) participated in a structured interview approximately 12 to 15 months following the offenders' arraignment. Results revealed that psychological DV severity and fear of the offender in the 30 days prior to arraignment significantly predicted PO level of restriction issued. In addition, level of restriction requested by the victim significantly predicted level of restriction issued by the judge (though closer examination of the data revealed that many orders were issued at a different level of restriction than the victim requested). Other demographic, relationship, parenting, and court-process-related factors did not predict PO level of restriction issued. Findings are discussed with respect to practice and policy in the criminal justice system.

The Afghan National Police: Turning a Counterinsurgency Problem into a Solution

DTIC Science & Technology

2009-12-01

27 “Special Forces groups are organized in small teams of 12 men — a.k.a. Operational Detachment Alpha (ODA). A typical Green Beret’s Team structure...Human Progress, 98. 162 Akbar S. Ahmed and David M. Hart, Islam in Tribal Societies: From the Atlas to the Indus (London; Boston: Routledge & Kegan ...Boston: Routledge & Kegan Paul, 1984. Al Jazeera. “Taliban Issue Code of Conduct.” Al Jazeera English Central/S. Asia (July 27, 2009), http

Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer.

PubMed

Chretien, Anne-Sophie; Harlé, Alexandre; Meyer-Lefebvre, Magali; Rouyer, Marie; Husson, Marie; Ramacci, Carole; Harter, Valentin; Genin, Pascal; Leroux, Agnès; Merlin, Jean-Louis

2013-02-01

KRAS mutation detection represents a crucial issue in metastatic colorectal cancer (mCRC). The optimization of KRAS mutation detection delay enabling rational prescription of first-line treatment in mCRC including anti-EGFR-targeted therapy requires robust and rapid molecular biology techniques. Routine analysis of mutations in codons 12 and 13 on 674 paraffin-embedded tissue specimens of mCRC has been performed for KRAS mutations detection using three molecular biology techniques, that is, high-resolution melting (HRM), polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), and allelic discrimination PCR (TaqMan PCR). Discordant cases were assessed with COBAS 4800 KRAS CE-IVD assay. Among the 674 tumor specimens, 1.5% (10/674) had excessive DNA degradation and could not be analyzed. KRAS mutations were detected in 38.0% (256/674) of the analysable specimens (82.4% in codon 12 and 17.6% in codon 13). Among 613 specimens in whom all three techniques were used, 12 (2.0%) cases of discordance between the three techniques were observed. 83.3% (10/12) of the discordances were due to PCR-RFLP as confirmed by COBAS 4800 retrospective analysis. The three techniques were statistically comparable (κ > 0.9; P < 0.001). From these results, optimization of the routine procedure consisted of proceeding to systematic KRAS detection using HRM and TaqMan and PCR-RFLP in case of discordance and allowed significant decrease in delays. The results showed an excellent correlation between the three techniques. Using HRM and TaqMan warrants high-quality and rapid-routine KRAS mutation detection in paraffin-embedded tumor specimens. The new procedure allowed a significant decrease in delays for reporting results, enabling rational prescription of first-line-targeted therapy in mCRC.

Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma

PubMed Central

Mirza, Z K; Das, K K; Slate, J; Mapitigama, R N; Amenta, P S; Griffel, L H; Ramsundar, L; Watari, J; Yokota, K; Tanabe, H; Sato, T; Kohgo, Y; Das, K M

2003-01-01

Background: Some forms of gastric intestinal metaplasia (GIM) may be precancerous but the cellular phenotype that predisposes to gastric carcinogenesis is not well characterised. Mucin staining, as a means of differentiating GIM, is difficult. A monoclonal antibody, mAb Das-1 (initially called 7E12H12), whose staining is phenotypically specific to colon epithelium, was used to investigate this issue. Methods: Using mAb Das-1, by a sensitive immunoperoxidase assay, we examined histologically confirmed GIM specimens from two countries, the USA and Japan. A total of 150 patients comprised three groups: group A, GIM (fields away from the cancer area) from patients with gastric carcinoma (n=60); group B, GIM with chronic gastritis (without gastric carcinoma) (n=72); and group C, chronic gastritis without GIM (n=18). Results: Fifty six of 60 (93%) patients with GIM (both goblet and non-goblet metaplastic cells) from group A reacted intensely with mAb Das-1. Cancer areas from the same 56 patients also reacted. In contrast, 25/72 (35%) samples of GIM from patients in group B reacted with mAb Das-1 (group A v B, p<0.0001). None of the samples from group C reacted with the mAb. Conclusions: Reactivity of mAb Das-1 is clinically useful to simplify and differentiate the phenotypes of GIM. The colonic phenotype of GIM, as identified by mAb Das-1, is strongly associated with gastric carcinoma. PMID:12740335

Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma.

PubMed

Mirza, Z K; Das, K K; Slate, J; Mapitigama, R N; Amenta, P S; Griffel, L H; Ramsundar, L; Watari, J; Yokota, K; Tanabe, H; Sato, T; Kohgo, Y; Das, K M

2003-06-01

Some forms of gastric intestinal metaplasia (GIM) may be precancerous but the cellular phenotype that predisposes to gastric carcinogenesis is not well characterised. Mucin staining, as a means of differentiating GIM, is difficult. A monoclonal antibody, mAb Das-1 (initially called 7E(12)H(12)), whose staining is phenotypically specific to colon epithelium, was used to investigate this issue. Using mAb Das-1, by a sensitive immunoperoxidase assay, we examined histologically confirmed GIM specimens from two countries, the USA and Japan. A total of 150 patients comprised three groups: group A, GIM (fields away from the cancer area) from patients with gastric carcinoma (n=60); group B, GIM with chronic gastritis (without gastric carcinoma) (n=72); and group C, chronic gastritis without GIM (n=18). Fifty six of 60 (93%) patients with GIM (both goblet and non-goblet metaplastic cells) from group A reacted intensely with mAb Das-1. Cancer areas from the same 56 patients also reacted. In contrast, 25/72 (35%) samples of GIM from patients in group B reacted with mAb Das-1 (group A v B, p<0.0001). None of the samples from group C reacted with the mAb. Reactivity of mAb Das-1 is clinically useful to simplify and differentiate the phenotypes of GIM. The colonic phenotype of GIM, as identified by mAb Das-1, is strongly associated with gastric carcinoma.

Design of highly selective ethanol dehydration nanocatalysts for ethylene production.

PubMed

Austin, Natalie; Kostetskyy, Pavlo; Mpourmpakis, Giannis

2018-02-22

Rational design of catalysts for selective conversion of alcohols to olefins is key since product selectivity remains an issue due to competing etherification reactions. Using first principles calculations and chemical rules, we designed novel metal-oxide-protected metal nanoclusters (M 13 X 4 O 12 , with M = Cu, Ag, and Au and X = Al, Ga, and In) exhibiting strong Lewis acid sites on their surface, active for the selective formation of olefins from alcohols. These symmetrical nanocatalysts, due to their curvature, show unfavorable etherification chemistries, while favoring the olefin production. Furthermore, we determined that water removal and regeneration of the nanocatalysts is more feasible compared to the equivalent strong acid sites on solid acids used for alcohol dehydration. Our results demonstrate an exceptional stability of these new nanostructures with the most energetically favorable being Cu-based. Thus, the high selectivity and stability of these in-silico-predicted novel nanoclusters (e.g. Cu 13 Al 4 O 12 ) make them attractive catalysts for the selective dehydration of alcohols to olefins.

The Density-wave Theory and Spiral Structures by Looking at Spiral Arms through a Multi-wavelength StudyHamed Pour-Imani1,2, Daniel Kennefick1,2, Julia Kennefick1,2, Mohamed Shameer Abdeen1,2, Eric Monson1,2, Douglas W. Shields1,2, B. L. Davis31Department of Physics, University of Arkansas, Fayetteville, AR 72701, USA2Arkansas Center for Space & Planetary Sciences, Univ. of Arkans

NASA Astrophysics Data System (ADS)

Pour-Imani, Hamed; Kennefick, Daniel; Kennefick, Julia; Shameer Abdeen, Mohammad; Monson, Erick; Shields, Douglas William; Davis, Benjamin L.

2018-01-01

The density-wave theory of spiral structure, though first proposed as long ago as the mid-1960s by C.C. Lin and F. Shu, continues to be challenged by rival theories, such as the manifold theory. One test between these theories which has been proposed is that the pitch angle of spiral arms for galaxies should vary with the wavelength of the image in the density-wave theory, but not in the manifold theory. The reason is that stars are born in the density wave but move out of it as they age. In this study, we combined large sample size with a wide range of wavelengths to investigate this issue. For each galaxy, we used wavelength FUV151nm, U-band, H-alpha, optical wavelength B-band and infrared 3.6 and 8.0μm. We measured the pitch angle with the 2DFFT and Spirality codes (Davis et al. 2012; Shields et al. 2015). We find that the B-band and 3.6μm images have smaller pitch angles than the infrared 8.0μm image in all cases, in agreement with the prediction of the density-wave theory. We also find that the pitch angle at FUV and H-alpha are close to the measurements made at 8.0μm. The Far-ultraviolet wavelength at 151nm shows very young, very bright UV stars still in the star-forming region (they are so bright as to be visible there and so short-lived that they never move out of it). We find that for both sets of measurements (2dFFT and Spirality) the 8.0μm, H-alpha and ultraviolet images agree in their pitch angle measurements, suggesting that they are, in fact, sensitive to the same region. By contrast, the 3.6μm and B-band images are uniformly tighter in pitch angle measurements than these wavelengths, suggesting that the density-wave picture is correct.

Bench-Scale Filtration Testing in Support of the Pretreatment Engineering Platform (PEP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Billing, Justin M.; Daniel, Richard C.; Kurath, Dean E.

Pacific Northwest National Laboratory (PNNL) has been tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed, constructed and operated as part of a plan to respond to issue M12, “Undemonstrated Leaching Processes.” The PEP is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes. The PEP testing program specifies that bench-scale testing is to bemore » performed in support of specific operations, including filtration, caustic leaching, and oxidative leaching.« less

Rail accelerator technology and applications

NASA Technical Reports Server (NTRS)

Zana, L. M.; Kerslake, W. R.

1985-01-01

Rail accelerators offer a viable means of launching ton-size payloads from the Earth's surface to space. The results of two mission studies which indicate that an Earth-to-Space Rail Launcher (ESRL) system is not only technically feasible but also economically beneficial, particularly when large amounts of bulk cago are to be delivered to space are given. An in-house experimental program at the Lewis Research Center (LeRC) was conducted in parallel with the mission studies with the objective of examining technical feasibility issues. A 1 m long - 12.5 by 12.5 mm bore rail accelerator as designed with clear polycarbonate sidewalls to visually observe the plasma armature acceleration. The general character of plasma/projectile dynamics is described for a typical test firing.

Automatic Sub-Pixel Co-Registration of LandSat-8 OLI and Sentinel-2A MSI Images Using Phase Correlation and Machine Learning Based Mapping

NASA Technical Reports Server (NTRS)

Skakun, Sergii; Roger, Jean-Claude; Vermote, Eric F.; Masek, Jeffrey G.; Justice, Christopher O.

2017-01-01

This study investigates misregistration issues between Landsat-8/OLI and Sentinel-2A/MSI at 30 m resolution, and between multi-temporal Sentinel-2A images at 10 m resolution using a phase correlation approach and multiple transformation functions. Co-registration of 45 Landsat-8 to Sentinel-2A pairs and 37 Sentinel-2A to Sentinel-2A pairs were analyzed. Phase correlation proved to be a robust approach that allowed us to identify hundreds and thousands of control points on images acquired more than 100 days apart. Overall, misregistration of up to 1.6 pixels at 30 m resolution between Landsat-8 and Sentinel-2A images, and 1.2 pixels and 2.8 pixels at 10 m resolution between multi-temporal Sentinel-2A images from the same and different orbits, respectively, were observed. The non-linear Random Forest regression used for constructing the mapping function showed best results in terms of root mean square error (RMSE), yielding an average RMSE error of 0.07+/-0.02 pixels at 30 m resolution, and 0.09+/-0.05 and 0.15+/-0.06 pixels at 10 m resolution for the same and adjacent Sentinel-2A orbits, respectively, for multiple tiles and multiple conditions. A simpler 1st order polynomial function (affine transformation) yielded RMSE of 0.08+/-0.02 pixels at 30 m resolution and 0.12+/-0.06 (same Sentinel-2A orbits) and 0.20+/-0.09 (adjacent orbits) pixels at 10 m resolution.

12 CFR 615.5110 - Authority to issue (other funding).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Authority to issue (other funding). 615.5110 Section 615.5110 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND FISCAL AFFAIRS, LOAN POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Other Funding § 615.5110 Authority to issue...

Differential Y-chromosome Anatolian influences on the Greek and Cretan Neolithic.

PubMed

King, R J; Ozcan, S S; Carter, T; Kalfoğlu, E; Atasoy, S; Triantaphyllidis, C; Kouvatsi, A; Lin, A A; Chow, C-E T; Zhivotovsky, L A; Michalodimitrakis, M; Underhill, P A

2008-03-01

The earliest Neolithic sites of Europe are located in Crete and mainland Greece. A debate persists concerning whether these farmers originated in neighboring Anatolia and the role of maritime colonization. To address these issues 171 samples were collected from areas near three known early Neolithic settlements in Greece together with 193 samples from Crete. An analysis of Y-chromosome haplogroups determined that the samples from the Greek Neolithic sites showed strong affinity to Balkan data, while Crete shows affinity with central/Mediterranean Anatolia. Haplogroup J2b-M12 was frequent in Thessaly and Greek Macedonia while haplogroup J2a-M410 was scarce. Alternatively, Crete, like Anatolia showed a high frequency of J2a-M410 and a low frequency of J2b-M12. This dichotomy parallels archaeobotanical evidence, specifically that while bread wheat (Triticum aestivum) is known from Neolithic Anatolia, Crete and southern Italy; it is absent from earliest Neolithic Greece. The expansion time of YSTR variation for haplogroup E3b1a2-V13, in the Peloponnese was consistent with an indigenous Mesolithic presence. In turn, two distinctive haplogroups, J2a1h-M319 and J2a1b1-M92, have demographic properties consistent with Bronze Age expansions in Crete, arguably from NW/W Anatolia and Syro-Palestine, while a later mainland (Mycenaean) contribution to Crete is indicated by relative frequencies of V13.

Atypical social development in neonatal intensive care unit survivors at 12 months.

PubMed

Yamada, Yasumasa; Yoshida, Futoshi; Hemmi, Hayato; Ito, Miharu; Kakita, Hiroki; Yoshikawa, Toru; Hishida, Manabu; Iguchi, Toshiyuki; Seo, Tomoko; Nakanishi, Keiko

2011-12-01

Owing to advances in neonatal intensive care, many infants who are hospitalized in neonatal intensive care units (NICU) can survive and grow, and are referred to as NICU survivors. However, social development in NICU survivors has not been fully explored. To examine the social development of NICU survivors, a questionnaire consisting of the Modified Checklist for Autism in Toddlers (M-CHAT) was used. The M-CHAT was completed by the parents of either NICU survivors (n= 117) or normally delivered children (control group, n= 112) during their regular medical checkups at a corrected age of 12 months. Ninety percent of NICU survivors and 63% of control children did not pass the M-CHAT screen. As it was originally designed for children aged 18-30 months, failed M-CHAT items could have been due to developmental issues and not due to autistic spectrum disorders. However, there was a significant difference in the total number of items failed between the two groups. In particular, many NICU survivors did not pass on M-CHAT items, such as oversensitivity to noise, unusual finger movements, and attempts to attract attention. Concerning perinatal complications, infants with low birthweight and/or the need for respiratory support tended to have a higher number of failures on all M-CHAT items. NICU survivors may have distinct developmental patterns of social communication, and should be followed up for assessment of social skills and neurological development. © 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.

Theory of Charge Transport in Organic Crystals: Lessons from the Past and Prospects for the Future

NASA Astrophysics Data System (ADS)

Kenkre, V. M.

2002-03-01

Interest in fundamental issues regarding charge transport in organic materials shifted in the early 80's from the field of crystals to the field of disordered systems after polaron theories[1,2] were successfully applied[2] to what was suspected to be a mobility transition in naphthalene[3]. Recent experiments on pentacene[4] have been responsible for a reversal of the shift: there is now a revival of interest in crystals particularly in basic questions regarding electron-phonon interactions, polaron formation, the nature of charge carriers, and the issue of band versus hopping transport. High magnitudes of the new mobilities appear to imply large free carrier bandwidths which have led some to conjecture that band (rather than hopping) transport is characteristic of pentacene[5]. And yet, pentacene experiments show an unmistakable rise in the mobility at higher temperature, a rise that seems to signal polaronic behavior. Added to this fascinating mélange of facts are clear velocity saturation effects[6] observed in pentacene[4] along with some cavalier interpretation attempts of those non-Ohmic effects. The purpose of the talk is to attempt to address basic issues raised by these observations. 1. R. Silbey and R. W. Munn, J. Chem. Phys. 72, 2763 (1980). 2. V. M. Kenkre, John D. Andersen, D.H. Dunlap, and C.B. Duke, Phys. Rev. Lett. 62, 1165 (1989); see also M. Pope and C. E. Swenberg, Electronic Processes in Organic Crystals and Polymers, 2nd ed. (Oxford Univ Press, New Yourk 1999), p. 968. 3. L. B. Schein, C. B. Duke, and A.R. McGhie, Phys. Rev. Lett. 40, 197 (1978); C. B. Duke and L. B. Schein, Physics Today 33, 42 (1980). 4. J. H. Schoen, C. Kloc, and B. Batlogg, Phys. Rev. Lett. 86, 3843 (2001); Phys. Rev. B63, 245201 (2001). 5. Note, however, a recent demonstration against bare band descriptions in pentacene provided by J. D. Andersen, L. Giuggioli, and V. M. Kenkre, Phys. Rev. B, submitted. 6. V. M. Kenkre and P. E. Parris, Phys. Rev. B, submitted; P. E. Parris, M. Kús and V. M. Kenkre, Phys. Lett. A 289, 188 (2001).

[Quantifying dialysis efficiency for middle molecules in haemodialysis and in convective and mixed techniques].

PubMed

Casino, F G; Lopez, T

2008-01-01

In contrast to the negative results of the primary analysis, secondary analyses of the HEMO study do support the clinical importance of middle molecule removal. This is in agreement with the findings of large observational studies showing an improvement in mortality and morbidity in dialysis patients treated with high-flux hemodialysis or convective techniques as compared to low-flux hemodialysis. For practical assessment of middle molecule removal, we suggest using the Kt/V of beta2-microglobulin (Kt/Vbeta2-m) with a reference (adequate) value of >or=0.66, which was the average value for the high-flux arm in the HEMO study. For patients on low-flux hemodialysis, where Kt/Vbeta2-m cannot reliably be assessed, we suggest using the Kt/V of vitamin B12 (Kt/VB12), with a reference (adequate) value of >or=0.74, adapted from the findings of the Case Mix Adequacy Study (AJKD 1999). To simplify the routine assessment of these indices, two nomograms are introduced: the first allows to estimate Kt/Vbeta2-m from the post- to pre-dialysis beta2-microglobulin concentration ratio, the second allows to estimate the diffusion dialysis clearance of vitamin B12 from the in vitro dialyzer KoAB12 and actual plasma water flow rate. While waiting for specific trials addressing the issue of dialysis adequacy related to middle molecule removal, clinical experience with the middle molecule indices could provide further quantitative tools for dialysis prescription and favor an increase in dialysis time (or frequency) and/or the use of high-flux hemodialysis and convective techniques.

17 CFR 270.12d3-1 - Exemption of acquisitions of securities issued by persons engaged in securities related businesses.

Code of Federal Regulations, 2010 CFR

2010-04-01

... securities issued by persons engaged in securities related businesses. 270.12d3-1 Section 270.12d3-1... in securities related businesses. (a) Notwithstanding section 12(d)(3) of the Act, a registered... securities related business, the determination required by paragraph (b) of this section shall be made as...

Sparse Generalized Fourier Series via Collocation-based Optimization

DTIC Science & Technology

2014-11-01

3(m03 +m221] φ7 =m40 + 2m22 +m04 φ8 =(m40 −m04)[(m30 +m12)2 − (m21 +m03)2] + 4(m31 + m13 )(m30 +m12)(m21 +m03) φ9 =(m31 + m13 )[(m30 +m12) 2 − (m21 +m03...2] φ10 =(m40 − 6m22 +m04)[(m30 +m12)4 − 6(m30 +m12)2(m21 +m203 + (m21 +m03)4] + 16(m31 − m13 )(m30 +m12)(m21 +m03)× × [(m30 +m12)2 − (m21 +m03)2] φ11...m40 − 6m22 +m04)(m30 +m12)(m21 +m03)× × [(m21 +m03)2 − (m30 +m12)2] − (m31 − m13 )[(m30 +m12)4 − 6(m30 +m12)2(m21 +m03)2 + (m21 +m03)4]. 9

An Analysis and Comparative Study of Job Characteristics Levels and Job Redesign Potential within the Strategic Air Command Maintenance Officer and Navigator Career Fields.

DTIC Science & Technology

1985-09-01

Job Diagnostic Survey National Norms Managerial Workers ... 40 5 . Comparison of Mean Scores of Affective Outcomes With Norms For Navigators...VV cis cda r-4 * 14 to 0 0 0 m V4 E- 0 ta a 7 27 Issue #2: Feasibility of job redesigni. As mentioned earlier, two questions we:!? answered in...C. Satisfaction with co-workers. Average items #4, #7, and #12 of Section Four. D. Satisfaction with supervision. Average items # 5 , #8, and # 14 of

Bibliography of Research Reports and Publications Issued by the Biodynamics and Bioengineering Division, 1944-1984.

DTIC Science & Technology

1985-04-01

Ratino, R.K.H. Geber , A.A. Karl, D.R. Nelson, "OPTO Electronic Methodology Suitable for Electroretinographic Investigations During Environmental Stess...R.K.H. Geber , A.A. Karl, D.R. Nelson, "OPTO Electronic Methodology Suitable for Electroretinographic Investigations During Environmental Stess...6 Section M -Page 167 Author Index Gaudio, R. L-62, 67 Gawain,G.C.V. A-12 Geber ,R.K.H. G-42,H-22 Geer,R.L. F-92 Gehrich,J.L. A-273 Gell,C.F. D-33,F-97

12 CFR 3.15 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... as defined in 12 U.S.C. 1818(k). Violation of a directive may result in assessment of civil money... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Purpose and scope. 3.15 Section 3.15 Banks and... Office to issue a directive under 12 U.S.C. 3907(b)(2). A directive is an order issued to a bank that...

12 CFR 3.15 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... as defined in 12 U.S.C. 1818(k). Violation of a directive may result in assessment of civil money... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Purpose and scope. 3.15 Section 3.15 Banks and... Office to issue a directive under 12 U.S.C. 3907(b)(2). A directive is an order issued to a bank that...

12 CFR 3.15 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... as defined in 12 U.S.C. 1818(k). Violation of a directive may result in assessment of civil money... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Purpose and scope. 3.15 Section 3.15 Banks and... Office to issue a directive under 12 U.S.C. 3907(b)(2). A directive is an order issued to a bank that...

12 CFR 3.15 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... as defined in 12 U.S.C. 1818(k). Violation of a directive may result in assessment of civil money... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Purpose and scope. 3.15 Section 3.15 Banks and... Office to issue a directive under 12 U.S.C. 3907(b)(2). A directive is an order issued to a bank that...

K-12 Issues Will Await President

ERIC Educational Resources Information Center

Hoff, David J.; Klein, Alyson

2008-01-01

At the end of a presidential campaign in which education received some attention but never emerged as a top-tier issue, analysts were trying to look beyond the week's election to the K-12 issues awaiting the next president and gauge where they might fit as a new administration prepares to grapple with a global economic crisis. While education…

Grade 12 Diploma Examination. Examen en vue du diplome douzieme annee. Complete Set, January 1990.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton.

The Alberta (Canada) Department of Education issues "Grade 12 Diploma Examinations" for various disciplines every six months (dated January and June of each year). Except for the English and Francais examinations (which are issued only in their own language), the examinations are issued in an English edition and a French edition. The…

26 CFR 1.163-12 - Deduction of original issue discount on instrument held by related foreign person.

Code of Federal Regulations, 2012 CFR

2012-04-01

... on which the amount is includible in income is determined with reference to the method of accounting... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Deduction of original issue discount on... Deductions for Individuals and Corporations § 1.163-12 Deduction of original issue discount on instrument...

26 CFR 1.163-12 - Deduction of original issue discount on instrument held by related foreign person.

Code of Federal Regulations, 2014 CFR

2014-04-01

... on which the amount is includible in income is determined with reference to the method of accounting... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Deduction of original issue discount on... Deductions for Individuals and Corporations § 1.163-12 Deduction of original issue discount on instrument...

26 CFR 1.163-12 - Deduction of original issue discount on instrument held by related foreign person.

Code of Federal Regulations, 2013 CFR

2013-04-01

... on which the amount is includible in income is determined with reference to the method of accounting... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Deduction of original issue discount on... Deductions for Individuals and Corporations § 1.163-12 Deduction of original issue discount on instrument...

Shrimp miR-12 Suppresses White Spot Syndrome Virus Infection by Synchronously Triggering Antiviral Phagocytosis and Apoptosis Pathways

PubMed Central

Shu, Le; Zhang, Xiaobo

2017-01-01

Growing evidence has indicated that the innate immune system can be regulated by microRNAs (miRNAs). However, the mechanism underlying miRNA-mediated simultaneous activation of multiple immune pathways remains unknown. To address this issue, the role of host miR-12 in shrimp (Marsupenaeus japonicus) antiviral immune responses was characterized in the present study. The results indicated that miR-12 participated in virus infection, host phagocytosis, and apoptosis in defense against white spot syndrome virus invasion. miR-12 could simultaneously trigger phagocytosis, apoptosis, and antiviral immunity through the synchronous downregulation of the expression of shrimp genes [PTEN (phosphatase and tensin homolog) and BI-1(transmembrane BAX inhibitor motif containing 6)] and the viral gene (wsv024). Further analysis showed that miR-12 could synchronously mediate the 5′–3′ exonucleolytic degradation of its target mRNAs, and this degradation terminated in the vicinity of the 3′ untranslated region sequence complementary to the seed sequence of miR-12. Therefore, the present study showed novel aspects of the miRNA-mediated simultaneous regulation of multiple immune pathways. PMID:28824612

33 CFR 230.12 - Notice of intent and scoping.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., DEPARTMENT OF DEFENSE PROCEDURES FOR IMPLEMENTING NEPA § 230.12 Notice of intent and scoping. As soon as... issues to be analyzed in depth. Public concerns on issues, studies needed, alternatives to be examined...

How cracks are hot and cool: a burning issue for this paper

NASA Astrophysics Data System (ADS)

Toussaint, Renaud; Santucci, Stéphane; Lengliné, Olivier; Maloy, Knut Jorgen; Vincent-Dospital, Tom; Naert-Giuillot, Muriel

2017-04-01

Material failure is accompanied by important heat exchange, with extremely high temperature - thousands of degrees - reached at crack tips. Such temperature may subsequently alter the mechanical properties of stressed solids, and finally facilitate their rupture. Thermal runaway weakening processes could indeed explain stick-slip motions and even be responsible for deep earthquakes. Therefore, to better understand and eventually prevent catastrophic rupture events, it appears crucial to establish an accurate energy budget of fracture propagation from a clear measure of the various energy dissipation sources. In this work, combining analytical calculations and numerical simulations, we directly relate the temperature field around a moving crack tip to the part α of mechanical energy converted into heat. Monitoring the slow crack growth in paper sheets with an infrared camera, we measure a significant fraction α = 12±4%. Besides, we show that (self-generated) heat accumulation could weaken our samples with microfibers combustion, and lead to a fast crack/dynamic failure/ regime. Reference: Toussaint, R., Lengline, O., Santucci, S., Vincent-Dospital, T., Naert-Guillot, M. and Maloy, K.J., How cracks are hot and cool: a burning issue for paper (2016), Soft Matter (12), 5563-5571, DOI: 10.1039/C6SM00615A

Early impact of robot-assisted partial nephrectomy on renal function as assessed by renal scintigraphy.

PubMed

Luciani, Lorenzo G; Chiodini, Stefano; Donner, Davide; Cai, Tommaso; Vattovani, Valentino; Tiscione, Daniele; Giusti, Guido; Proietti, Silvia; Chierichetti, Franca; Malossini, Gianni

2016-06-01

To measure the early impact of robot-assisted partial nephrectomy (RAPN) on renal function as assessed by renal scan (Tc 99m-DTPA), addressing the issue of risk factors for ischemic damage to the kidney. All patients undergoing RAPN for cT1 renal masses between June 2013 and May 2014 were included in this prospective study. Renal function as expressed by glomerular filtration rate (GFR) was assessed by Technetium 99m-diethylenetriaminepentaacetic acid (Tc 99m-DTPA) renal scan preoperatively and postoperatively at 1 month in every patient. A multivariable analysis was used for the determination of independent factors predictive of GFR decrease of the operated kidney. Overall, 32 patients underwent RAPN in the time interval. Median tumor size, blood loss, and ischemia time were 4 cm, 200 mL, and 24 min, respectively. Two grade III complications occurred (postoperative bleeding in the renal fossa, urinoma). The GFR of the operated kidney decreased significantly from 51.7 ± 15.1 mL/min per 1.73 m(2) preoperatively to 40, 12 ± 12.4 mL/min per 1.73 m(2) 1 month postoperatively (p = 0.001) with a decrease of 22.4 %. On multivariable analysis, only tumor size (p = 0.05) was a predictor of GFR decrease of the operated kidney. Robotic-assisted partial nephrectomy had a detectable impact on early renal function in a series of relatively large tumors and prevailing intermediate nephrometric risk. A mean decrease of 22 % of GFR as assessed by renal scan in the operated kidney was found at 1 month postoperatively. In multivariable analysis, tumor size only was a significant predictor of renal function loss.

The fluorescence properties of aerosol larger than 0.8 μm in an urban and a PBA-dominated location

NASA Astrophysics Data System (ADS)

Gabey, A. M.; Stanley, W. R.; Gallagher, M. W.; Kaye, P. H.

2011-01-01

Dual-wavelength Ultraviolet light-induced fluorescence (UV-LIF) measurements were performed on ambient environmental aerosol in Manchester, UK (urban city centre, winter) and Borneo, Malaysia (remote, tropical), which are taken to represent environments with negligible and significant primary biological aerosol (PBA) influences, respectively. Single-particle fluorescence intensity and optical equivalent diameter were measured with a Wide Issue Bioaerosol Sensor, version 3 (WIBS3) in the diameter range 0.8 μm≤DP≤20 μm for 2-3 weeks and filters were analysed using energy dispersive X-ray (EDX) spectroscopy, which revealed mostly non-PBA dominated particle sizes larger than 1 μm in Manchester. The WIBS3 features three fluorescence channels: Fluorescence excited at 280 nm is recorded at 310-400 nm and 400-600 nm and fluorescence excited at 370 nm is detected at 400-600 nm. In Manchester the primary size mode of fluorescent and non-fluorescent material was at 1.2 μm. In Borneo non-fluorescent material peaked at 1.2 μm and fluorescent at 3-4 μm. The fluorescence intensity at 400-600 nm generally increased with DP at both sites, as did the 310-400 nm intensity in Borneo. In Manchester the 310-400 m fluorescence decreased at DP>4 μm, suggesting this channel offers additional discrimination between fluorescent particle types. Finally, the ratio of fluorescence intensity in two pairs of channels was investigated as a function of particle diameter and this varied significantly between the two environments, demonstrating that the fluorescent aerosol in each can in principle be distinguished using a combination of fluorescence and elastic scattering measurements.

LiDAR and IFSAR-Based Flood Inundation Model Estimates for Flood-Prone Areas of Afghanistan

NASA Astrophysics Data System (ADS)

Johnson, W. C.; Goldade, M. M.; Kastens, J.; Dobbs, K. E.; Macpherson, G. L.

2014-12-01

Extreme flood events are not unusual in semi-arid to hyper-arid regions of the world, and Afghanistan is no exception. Recent flashfloods and flashflood-induced landslides took nearly 100 lives and destroyed or damaged nearly 2000 homes in 12 villages within Guzargah-e-Nur district of Baghlan province in northeastern Afghanistan. With available satellite imagery, flood-water inundation estimation can be accomplished remotely, thereby providing a means to reduce the impact of such flood events by improving shared situational awareness during major flood events. Satellite orbital considerations, weather, cost, data licensing restrictions, and other issues can often complicate the acquisition of appropriately timed imagery. Given the need for tools to supplement imagery where not available, complement imagery when it is available, and bridge the gap between imagery based flood mapping and traditional hydrodynamic modeling approaches, we have developed a topographic floodplain model (FLDPLN), which has been used to identify and map river valley floodplains with elevation data ranging from 90-m SRTM to 1-m LiDAR. Floodplain "depth to flood" (DTF) databases generated by FLDPLN are completely seamless and modular. FLDPLN has been applied in Afghanistan to flood-prone areas along the northern and southern flanks of the Hindu Kush mountain range to generate a continuum of 1-m increment flood-event models up to 10 m in depth. Elevation data used in this application of FLDPLN included high-resolution, drone-acquired LiDAR (~1 m) and IFSAR (5 m; INTERMAP). Validation of the model has been accomplished using the best available satellite-derived flood inundation maps, such as those issued by Unitar's Operational Satellite Applications Programme (UNOSAT). Results provide a quantitative approach to evaluating the potential risk to urban/village infrastructure as well as to irrigation systems, agricultural fields and archaeological sites.

3-D Particle Simulation of Strongly-Coupled Chains of Charged Polymers

NASA Astrophysics Data System (ADS)

Tanaka, Toyoichi; Tanaka, Motohiko; Pande, V.; Grosberg, A.

1996-11-01

The behaviors of the polyampholyte (PA) which is a connected chain of charged beads (molecules) submerged in the neutral solvent is studied using the 3-D particle simulation code. The major issue is how an equilibrium and kinetics of the PA depend on the thermal and electrostatic forces, i.e., the coupling constant Γ= e^2/aT . We follow a dynamical evolution of the PA, considering the electrostatic force, (2) the binding force between the adjacent beads, (3) the random thermal force exerted by the solvent, and (4) the frictional force: m fracdv_idt = sumj fracZ_iZj e^2 |ri -r_j|^2 hatr_ij - frac3Ta^2(2 ri -r_i+1 -r_i-1) + F^(th) - m ν v_i. Preliminary runs show that, when the excess charge δ N on the chain is larger than N^1/2 ( N : the number of the beads), the size of the polyampholyte increases as in the Monte Carlo simulation using the energy principle [Kantor, Kardar and Li, Phys.Rev.E, 49, 1383 (1994)]. The measured time rate of the size increase for the fixed value of Γ is scaled as, d/dt ~ δ N - N^1/2 for δ N > N^1/2 , and d/dt ~ 0 otherwise.

Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery.

PubMed

Sayadi, Lohrasb R; Banyard, Derek A; Ziegler, Mary E; Obagi, Zaidal; Prussak, Jordyne; Klopfer, Michael J; Evans, Gregory Rd; Widgerow, Alan D

2018-06-01

Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of poorly healing wounds whose etiologies are often associated with aberrancies in tissue oxygenation. To address this issue, several modes of tissue oxygen delivery systems exist, including Hyperbaric Oxygen Therapy (HBOT) and Topical Oxygen Therapy (TOT), but their efficacies have yet to be fully substantiated. Micro/nanobubbles (MNBs), which range anywhere from 100 μm to <1 μm in diameter and are relatively stable for hours, offer a new mode of oxygen delivery to wounds. The aim of this article is to systematically review literature examining the use of TOT for wound healing and use of MNBs for tissue oxygenation using the MEDLINE database. The search yielded 87 articles (12 MNB articles and 75 TOT articles), of which 52 met the inclusion criteria for this literature review (12 MNB articles and 40 TOT articles). Additionally, we present an analysis on the efficacy of our MNB generating technology and propose its use as a wound healing agent. © 2018 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

The remarkable occurrence of large rainfall-induced debris flows at two different locations on July 12, 2008, Southern Sierra Nevada, CA, USA

USGS Publications Warehouse

DeGraff, J.V.; Wagner, D.L.; Gallegos, A.J.; DeRose, M.; Shannon, C.; Ellsworth, T.

2011-01-01

On July 12, 2008, two convective cells about 155 km apart produced a brief period of intense rainfall triggering large debris flows in the southern Sierra Nevada. The northernmost cell was centered over Oak Creek Canyon, an east-flowing drainage, and its tributaries near Independence, CA, USA. About 5:00 P.M., debris flows passed down the South Fork and North Fork of Oak Creek to merge into a large single feature whose passage affected the historic Mt. Whitney Fish hatchery and blocked California State Highway 395. At about the same time, the southernmost cell was largely centered over Erskine Creek, a main tributary of the west-flowing Kern River. Debris flows issued from several branches to coalesce into a large debris flow that passed along Erskine Creek, through the town of Lake Isabella, CA, USA and into the Kern River. It was observed reaching Lake Isabella about 6:30 P.M. Both debris flows caused significant disruption and damage to local communities. ?? 2011 Springer-Verlag.

12W laser amplification at 1427nm on the 4F 3/2 to 4I 13/2 spectral line in an Nd 3+ doped fused silica optical fiber

DOE PAGES

Dawson, Jay W.; Pax, Paul H.; Allen, Graham S.; ...

2016-12-08

A 9.3dB improvement in optical gain and a 100x improvement in total optical power over prior published experimental results from the 4F 3/2 to 4I 13/2 transition in an Nd 3+ doped fused silica optical fiber is demonstrated. This is enabled via an optical fiber waveguide design that creates high spectral attenuation in the 1050-1120nm-wavelength range, a continuous spectral filter for the primary 4F 3/2 to 4I 11/2 optical transition. A maximum output power at 1427nm of 1.2W was attained for 43mW coupled seed laser power and 22.2W of coupled pump diode laser power at 880nm a net optical gainmore » of 14.5dB. Reducing the coupled seed laser power to 2.5mW enabled the system to attain 19.3dB of gain for 16.5W of coupled pump power. Four issues limited results; non-optimal seed laser wavelength, amplified spontaneous emission on the 4F 3/2 to 4I 9/2 optical transition, low absorption of pump light from the cladding and high spectral attenuation in the 1350-1450nm range. Lastly, future fibers that mitigate these issues should lead to significant improvements in the efficiency of the laser amplifier, though the shorter wavelength region of the transition from 1310nm to >1350nm is still expected to be limited by excited state absorption.« less

12W laser amplification at 1427nm on the 4F 3/2 to 4I 13/2 spectral line in an Nd 3+ doped fused silica optical fiber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dawson, Jay W.; Pax, Paul H.; Allen, Graham S.

A 9.3dB improvement in optical gain and a 100x improvement in total optical power over prior published experimental results from the 4F 3/2 to 4I 13/2 transition in an Nd 3+ doped fused silica optical fiber is demonstrated. This is enabled via an optical fiber waveguide design that creates high spectral attenuation in the 1050-1120nm-wavelength range, a continuous spectral filter for the primary 4F 3/2 to 4I 11/2 optical transition. A maximum output power at 1427nm of 1.2W was attained for 43mW coupled seed laser power and 22.2W of coupled pump diode laser power at 880nm a net optical gainmore » of 14.5dB. Reducing the coupled seed laser power to 2.5mW enabled the system to attain 19.3dB of gain for 16.5W of coupled pump power. Four issues limited results; non-optimal seed laser wavelength, amplified spontaneous emission on the 4F 3/2 to 4I 9/2 optical transition, low absorption of pump light from the cladding and high spectral attenuation in the 1350-1450nm range. Lastly, future fibers that mitigate these issues should lead to significant improvements in the efficiency of the laser amplifier, though the shorter wavelength region of the transition from 1310nm to >1350nm is still expected to be limited by excited state absorption.« less

ALMA specifications and results: report at mid-cycle 3

NASA Astrophysics Data System (ADS)

Dent, W. R. F.

2016-07-01

ALMA is now nearing the end of its third cycle of operations, and is transitioning from `early science' to regular PI-driven observing. The array has been operated over the complete range of available baseline lengths, from <10m with the ACA out to the maximum of 16km in the long-baseline configuration. Typically 40 12m-diameter antennas are now used at any one time. In this paper, we summarise the advertised capabilities and how they have evolved in the first 5 years, the proposal pressure and `hot spots', and describe some of the issues with the real measured system performance. We also outline the observing statistics, project completion rates, and papers from ALMA. Finally we highlight some of the new transformational science coming from this facility.

Systems Engineering Measurement Primer

DTIC Science & Technology

1998-03-01

Schermerhorn , R ., “Determining metrics for...maintenance process. 12 S e l e c t a n d S p e c i f y M e a s u r e s a n d I n d i c a t o r s C o l l e c t D a t a C a l c u l a t e I n d i c a...t o r s A n a l y z e t h e M e a s u r e s o r I n d i c a t o r s R e p o r t a n d U s e t h e R e s u l t s Issues Goals Risks A

12 CFR 1202.1 - Why did FHFA issue this part?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Why did FHFA issue this part? 1202.1 Section... INFORMATION ACT § 1202.1 Why did FHFA issue this part? (a) The Freedom of Information Act (FOIA) (5 U.S.C. 552... information about yourself under the Privacy Act (5 U.S.C. 552a), you should file your request using FHFA's...

"It's Worth Our Time": A Model of Culturally and Linguistically Supportive Professional Development for K-12 STEM Educators

ERIC Educational Resources Information Center

Hudley, Anne H. Charity; Mallinson, Christine

2017-01-01

Professional development on issues of language and culture is often separate from professional development on issues related to STEM education, resulting in linguistic and cultural gaps in K-12 STEM pedagogy and practice. To address this issue, we have designed a model of professional development in which we work with educators to build cultural…

An evaluation of patients' experienced usability of a diabetes mHealth system using a multi-method approach.

PubMed

Georgsson, Mattias; Staggers, Nancy

2016-02-01

mHealth systems are becoming more common to aid patients in their diabetes self-management, but recent studies indicate a need for thorough evaluation of patients' experienced usability. Current evaluations lack a multi-method design for data collection and structured methods for data analyses. The purpose of this study was to provide a feasibility test of a multi-method approach for both data collection and data analyses for patients' experienced usability of a mHealth system for diabetes type 2 self-management. A random sample of 10 users was selected from a larger clinical trial. Data collection methods included user testing with eight representative tasks and Think Aloud protocol, a semi-structured interview and a questionnaire on patients' experiences using the system. The Framework Analysis (FA) method and Usability Problem Taxonomy (UPT) were used to structure, code and analyze the results. A usability severity rating was assigned after classification. The combined methods resulted in a total of 117 problems condensed into 19 usability issues with an average severity rating of 2.47 or serious. The usability test detected 50% of the initial usability problems, followed by the post-interview at 29%. The usability test found 18 of 19 consolidated usability problems while the questionnaire uncovered one unique issue. Patients experienced most usability problems (8) in the Glucose Readings View when performing complex tasks such as adding, deleting, and exporting glucose measurements. The severity ratings were the highest for the Glucose Diary View, Glucose Readings View, and Blood Pressure View with an average severity rating of 3 (serious). Most of the issues were classified under the artifact component of the UPT and primary categories of Visualness (7) and Manipulation (6). In the UPT task component, most issues were in the primary category Task-mapping (12). Multiple data collection methods yielded a more comprehensive set of usability issues. Usability testing uncovered the largest volume of usability issues, followed by interviewing and then the questionnaire. The interview did not surface any unique consolidated usability issues while the questionnaire surfaced one. The FA and UPT were valuable in structuring and classifying problems. The resulting descriptions serve as a communication tool in problem solving and programming. We recommend the usage of multiple methods in data collection and employing the FA and UPT in data analyses for future usability testing. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

The role of adolescents' morality and identity in volunteering. Age and gender differences in a process model.

PubMed

van Goethem, Anne A J; van Hoof, Anne; van Aken, Marcel A G; Raaijmakers, Quinten A W; Boom, Jan; de Castro, Bram Orobio

2012-06-01

The aim of this study was to explain adolescents' volunteering in terms of their morality and identity and to examine the moderation effect of gender and age in this process. Data were collected among 698 Dutch adolescents aged 12 to 20 (M = 15.19; SD = 1.43). Adolescents' moral reasoning was positively associated with understanding moral issues and thinking about public responsibility towards these issues. In turn, moral understanding, along with being personally committed to act upon moral issues, were positively associated with identity. Extending the number of identity contexts tended to be related to being more likely to volunteer and to more volunteering involvement. Adolescents' identity integration was not related to how likely they were to volunteer, and was negatively related to their volunteering involvement. Clearer effects were found when differentiating between adolescent gender and age groups. Future research could examine this process over time, along with additional factors that may further explain adolescents' volunteering, and examine their age and gender specific effects. Copyright © 2011 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

77 FR 41403 - Meetings of the Local Government Advisory Committee and the Small Communities Advisory...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... Tuesday, July 31, 2012, 1 p.m.-2 p.m. (EDT). The Committee will discuss air quality issues, water quality.... (EDT). The Committee will discuss air quality issues, water quality issues, environmental justice and...

Seismic, satellite, and site observations of internal solitary waves in the NE South China Sea.

PubMed

Tang, Qunshu; Wang, Caixia; Wang, Dongxiao; Pawlowicz, Rich

2014-06-20

Internal solitary waves (ISWs) in the NE South China Sea (SCS) are tidally generated at the Luzon Strait. Their propagation, evolution, and dissipation processes involve numerous issues still poorly understood. Here, a novel method of seismic oceanography capable of capturing oceanic finescale structures is used to study ISWs in the slope region of the NE SCS. Near-simultaneous observations of two ISWs were acquired using seismic and satellite imaging, and water column measurements. The vertical and horizontal length scales of the seismic observed ISWs are around 50 m and 1-2 km, respectively. Wave phase speeds calculated from seismic observations, satellite images, and water column data are consistent with each other. Observed waveforms and vertical velocities also correspond well with those estimated using KdV theory. These results suggest that the seismic method, a new option to oceanographers, can be further applied to resolve other important issues related to ISWs.

PEP Run Report for Integrated Test A, Caustic Leaching in UFP-VSL-T01A, Oxidative Leaching in UFP-VSL-T02A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guzman-Leong, Consuelo E.; Bredt, Ofelia P.; Burns, Carolyn A.

2009-12-04

Pacific Northwest National Laboratory (PNNL) was tasked by Bechtel National Inc. (BNI) on the River Protection Project-Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to perform research and development activities to resolve technical issues identified for the Pretreatment Facility (PTF). The Pretreatment Engineering Platform (PEP) was designed and constructed and operated as part of a plan to respond to issue M12, “Undemonstrated Leaching Processes.”(a) The PEP, located in the Process Engineering Laboratory-West (PDLW) located in Richland, Washington, is a 1/4.5-scale test platform designed to simulate the WTP pretreatment caustic leaching, oxidative leaching, ultrafiltration solids concentration, and slurry washing processes.more » The PEP replicates the WTP leaching processes using prototypic equipment and control strategies. The PEP also includes non-prototypic ancillary equipment to support the core processing.« less

Introduction to “Global tsunami science: Past and future, Volume II”

USGS Publications Warehouse

Rabinovich, Alexander B.; Fritz, Hermann M.; Tanioka, Yuichiro; Geist, Eric L.

2017-01-01

Twenty-two papers on the study of tsunamis are included in Volume II of the PAGEOPH topical issue “Global Tsunami Science: Past and Future”. Volume I of this topical issue was published as PAGEOPH, vol. 173, No. 12, 2016 (Eds., E. L. Geist, H. M. Fritz, A. B. Rabinovich, and Y. Tanioka). Three papers in Volume II focus on details of the 2011 and 2016 tsunami-generating earthquakes offshore of Tohoku, Japan. The next six papers describe important case studies and observations of recent and historical events. Four papers related to tsunami hazard assessment are followed by three papers on tsunami hydrodynamics and numerical modelling. Three papers discuss problems of tsunami warning and real-time forecasting. The final set of three papers importantly investigates tsunamis generated by non-seismic sources: volcanic explosions, landslides, and meteorological disturbances. Collectively, this volume highlights contemporary trends in global tsunami research, both fundamental and applied toward hazard assessment and mitigation.

Introduction to "Global Tsunami Science: Past and Future, Volume II"

NASA Astrophysics Data System (ADS)

Rabinovich, Alexander B.; Fritz, Hermann M.; Tanioka, Yuichiro; Geist, Eric L.

2017-08-01

Twenty-two papers on the study of tsunamis are included in Volume II of the PAGEOPH topical issue "Global Tsunami Science: Past and Future". Volume I of this topical issue was published as PAGEOPH, vol. 173, No. 12, 2016 (Eds., E. L. Geist, H. M. Fritz, A. B. Rabinovich, and Y. Tanioka). Three papers in Volume II focus on details of the 2011 and 2016 tsunami-generating earthquakes offshore of Tohoku, Japan. The next six papers describe important case studies and observations of recent and historical events. Four papers related to tsunami hazard assessment are followed by three papers on tsunami hydrodynamics and numerical modelling. Three papers discuss problems of tsunami warning and real-time forecasting. The final set of three papers importantly investigates tsunamis generated by non-seismic sources: volcanic explosions, landslides, and meteorological disturbances. Collectively, this volume highlights contemporary trends in global tsunami research, both fundamental and applied toward hazard assessment and mitigation.

JPRS Report, East Asia, Korea: Kulloja, Issue No. 12, December 1986.

DTIC Science & Technology

1987-06-25

DiGlrib-uliori Unlimited East Asia Korea: KULLOJA ISSUE No 12 , DECEMBER 1986 REPRODUCED BY U S DEPARTMENT OF COMMERCE NATIONAL TECHNICAL...INFORMATIONSERVICE SPRINGFIELD, VA 22161 .MIC QUALITY msp&JnsD i ro 10 JPRS-AKU-87-003 25 JUNE 1987 KOREAN AFFAIRS REPORT KULLOJA No 12 , DECEMBER...KULLOJA in Korean No 12 , Dec 86 pp 3-16 [Text] Recently, our people’s interest in sports and athletic activities has evermore been intensifying. I think

You and Your Child: Practical Child Development Information from High/Scope for Parents, with Helpful Support Strategies To Use at Home.

ERIC Educational Resources Information Center

Vogel, Nancy

This document is comprised of 12 issues of a High/Scope newsletter designed to give parents information on child development and to provide suggestions for ways parents can support their preschool child's development at home. Each issue focuses on one aspect of development or learning. The topics for the 12 issues are: (1) dramatic play; (2)…

75 FR 11563 - Jovencio L. Raneses, M.D.; Denial of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Jovencio L. Raneses, M.D.; Denial of... Enforcement Administration, issued an Order to Show Cause to Jovencio L. Raneses, M.D. (Respondent), of San... issued by the Medical Board of California. See In re Jovencio L. Raneses, M.D., Default Decision and...

Extended-spectrum beta-lactamase-producing bacteria isolated from hematologic patients in Manaus, State of Amazonas, Brazil

PubMed Central

Ferreira, Cristina Motta; Ferreira, William Antunes; Almeida, Nayanne Cristina Oliveira da Silva; Naveca, Felipe Gomes; Barbosa, Maria das Graças Vale

2011-01-01

Antibiotic therapy in hematologic patients, often weak and susceptible to a wide range of infections, particularly nosocomial infections derived from long hospitalization periods, is a challenging issue. This paper presents ESBL-producing strains isolated from such hematologic patients treated at the Amazon Hematology and Hemotherapy Foundation (HEMOAM) in the Brazilian Amazon Region to identify the ESBL genes carried by them as well as the susceptibility to 11 antimicrobial agents using the E-test method. A total of 146 clinical samples were obtained from July 2007 to August 2008, when 17 gram-negative strains were isolated in our institution. The most frequent isolates confirmed by biochemical tests and 16S rRNA sequencing were E. coli (8/17), Serratia spp. (3/17) and B.cepacia (2/17). All gram-negative strains were tested for extended-spectrum-beta-lactamases (ESBLs), where: (12/17) strains carried ESBL; among these, (8/12) isolates carried blaTEM, blaCTX-M, blaOXA , blaSHV genes, (1/12) blaTEM gene and (3/12) blaTEM, blaCTX-M, blaOXA genes. Antibiotic resistance was found in (15/17) of the isolates for tetracycline, (12/17) for ciprofloxacin, (1/17) resistance for cefoxitin and chloramphenicol, (1/17) for amikacin and (3/17) cefepime. This research showed the presence of gram-negative ESBL-producing bacteria infecting hematologic patients in HEMOAM. These strains carried the blaTEM, blaSHV, blaCTX-M and blaOXA genes and were resistant to different antibiotics used in the treatment. This finding was based on a period of 13 months, during which clinical samples from specific populations were obtained. Therefore, caution is required when generalizing the results that must be based on posological orientations and new breakpoints for disk diffusion and microdilution published by CLSI 2010. PMID:24031725

Systematic search for major genes in schizophrenia: Methodological issues and results from chromosome 12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dawson, E.; Powell, J.F.; Sham, P.

1995-10-09

We describe a method of systematically searching for major genes in disorders of unknown mode of inheritance, using linkage analysis. Our method is designed to minimize the probability of missing linkage due to inadequate exploration of data. We illustrate this method with the results of a search for a locus for schizophrenia on chromosome 12 using 22 highly polymorphic markers in 23 high density pedigrees. The markers span approximately 85-90% of the chromosome and are on average 9.35 cM apart. We have analysed the data using the most plausible current genetic models and allowing for the presence of genetic heterogeneity.more » None of the markers was supportive of linkage and the distribution of the heterogeneity statistics was in accordance with the null hypothesis. 53 refs., 2 figs., 4 tabs.« less

76 FR 7182 - National Assessment Governing Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

... Session--12 p.m.-4:15 p.m. Executive Committee: Open Session--4:30 p.m. to 5:15 p.m.; Closed Session--5:15 p.m. to 6 p.m. March 4: Full Board: Open Session--8:15 a.m. to 10 a.m.; Closed Session-- 12:45 p.m...: Closed Session--10:20 a.m. to 12:0 p.m.; Open session 12:25 p.m.-12:30 p.m. Committee on Standards...

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

75 FR 8749 - Dwayne LaFrantz Wilson, M.D.; Revocation of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Dwayne LaFrantz Wilson, M.D.; Revocation of... Enforcement Administration, issued an Order to Show Cause to Dwayne LaFrantz Wilson, M.D. (Respondent), of... Registration, BW6030857, issued to Dwayne LaFrantz Wilson, M.D., be, and it hereby is, revoked. I further order...

75 FR 49955 - Hung Thien Ly, M.D.; Revocation of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Hung Thien Ly, M.D.; Revocation of... Enforcement Administration, issued an Order to Show Cause to Hung Thien Ly, M.D. (Respondent), of McRae..., BL8586147, issued to Hung Thien Ly, M.D., be, and it hereby is, revoked. I further order that any pending...

Women in Combat: What Next?

DTIC Science & Technology

1992-06-16

other things, they must consider deployment issues, coalition partners, pregnancy, unit cohesion, strength issues, sexual harassment and fraternization...Among other things, they must consider deployment issues, coalition partners, pregnancy, unit cohesion, strength issues. sexual harassment and...11 Deployment Issues - Pregnancy/Absenteeism ... ...... 12 Unit Cohesion and Bonding .... .............. ... 14 Sexual Harassment

Cluster-assembled materials based on M12N12 (M = Al, Ga) fullerene-like clusters.

PubMed

Yong, Yongliang; Song, Bin; He, Pimo

2011-09-28

We report the results of density functional theory calculations on cluster-assembled materials based on M(12)N(12) (M = Al, Ga) fullerene-like clusters. Our results show that the M(12)N(12) fullerene-like structure with six isolated four-membered rings (4NRs) and eight six-membered rings (6NRs) has a T(h) symmetry and a large HOMO-LUMO gap, indicating that the M(12)N(12) cluster would be ideal building blocks for the synthesis of cluster-assembled materials. Via the coalescence of M(12)N(12) building blocks, we find that the M(12)N(12) clusters can bind into stable assemblies by either 6NR or 4NR face coalescence, which enables the construction of rhombohedral or cubic nanoporous framework of varying porosity. The rhombohedral-MN phase is energetically more favorable than the cubic-MN phase. The M(12)N(12) fullerene-like structures in both phases are maintained and the M-N bond lengths between M(12)N(12) monomers are slightly larger than that in isolated M(12)N(12) clusters and the bulk wurtzite phases. The band analysis of both phases reveals that they are all wide-gap semiconductors. Because of the nanoporous character of these phases, they could be used for gas storage, heterogeneous catalysis, filtration and so on.

Understanding the thermostability and activity of Bacillus subtilis lipase mutants: insights from molecular dynamics simulations.

PubMed

Singh, Bipin; Bulusu, Gopalakrishnan; Mitra, Abhijit

2015-01-15

Improving the thermostability of industrial enzymes is an important protein engineering challenge. Point mutations, induced to increase thermostability, affect the structure and dynamics of the target protein in several ways and thus can also affect its activity. There appears to be no general rules for improving the thermostabilty of enzymes without adversely affecting their enzymatic activity. We report MD simulations, of wild type Bacillus subtilis lipase (WT) and its six progressively thermostable mutants (2M, 3M, 4M, 6M, 9M, and 12M), performed at different temperatures, to address this issue. Less thermostable mutants (LTMs), 2M to 6M, show WT-like dynamics at all simulation temperatures. However, the two more thermostable mutants (MTMs) show the required flexibility at appropriate temperature ranges and maintain conformational stability at high temperature. They show a deep and rugged free-energy landscape, confining them within a near-native conformational space by conserving noncovalent interactions, and thus protecting them from possible aggregation. In contrast, the LTMs having marginally higher thermostabilities than WT show greater probabilities of accessing non-native conformations, which, due to aggregation, have reduced possibilities of reverting to their respective native states under refolding conditions. Our analysis indicates the possibility of nonadditive effects of point mutations on the conformational stability of LTMs.

Simulation of temporal and spatial distribution of required irrigation water by crop models and the pan evaporation coefficient method

NASA Astrophysics Data System (ADS)

Yang, Yan-min; Yang, Yonghui; Han, Shu-min; Hu, Yu-kun

2009-07-01

Hebei Plain is the most important agricultural belt in North China. Intensive irrigation, low and uneven precipitation have led to severe water shortage on the plain. This study is an attempt to resolve this crucial issue of water shortage for sustainable agricultural production and water resources management. The paper models distributed regional irrigation requirement for a range of cultivated crops on the plain. Classic crop models like DSSAT- wheat/maize and COTTON2K are used in combination with pan-evaporation coefficient method to estimate water requirements for wheat, corn, cotton, fruit-trees and vegetables. The approach is more accurate than the static approach adopted in previous studies. This is because the combination use of crop models and pan-evaporation coefficient method dynamically accounts for irrigation requirement at different growth stages of crops, agronomic practices, and field and climatic conditions. The simulation results show increasing Required Irrigation Amount (RIA) with time. RIA ranges from 5.08×109 m3 to 14.42×109 m3 for the period 1986~2006, with an annual average of 10.6×109 m3. Percent average water use by wheat, fruit trees, vegetable, corn and cotton is 41%, 12%, 12%, 11%, 7% and 17% respectively. RIA for April and May (the period with the highest irrigation water use) is 1.78×109 m3 and 2.41×109 m3 respectively. The counties in the piedmont regions of Mount Taihang have high RIA while the central and eastern regions/counties have low irrigation requirement.

Groundwater Protection Program Management Plan For The U.S. Department Of Energy Y-12 National Security Complex, Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental, LLC

2009-09-01

This document presents the Groundwater Protection Program (GWPP) management plan for the U.S. Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12). The Y-12 GWPP functions as the primary point-of-contact for groundwater-related issues at Y-12, provides stewardship of the extensive network of groundwater monitoring wells at Y-12, and serves as a resource for technical expertise, support, and historical data for groundwater-related activities at Y-12. These organizational functions each serve the primary programmatic purpose of the GWPP, which is to ensure that groundwater monitoring activities within areas under Y-12 administrative control provide representative data in compliance with themore » multiple purposes of applicable state and federal regulations, DOE orders, and the corporate policies of Babcock & Wilcox Technical Services Y-12 LLC (hereafter referenced as B&W Y-12), the Y-12 management and operations (M&O) contractor for DOE. B&W Y-12 is a new corporate name, assumed in January 2007, for the company formerly known as BWXT Y-12, L.L.C., hereafter referenced as BWXT. This GWPP management plan addresses the requirements of DOE Order 450.1A Environmental Protection Program (hereafter referenced as DOE O 450.1A), which emphasize a site-wide approach for groundwater protection at each DOE facility through implementation of groundwater surveillance monitoring. Additionally, this plan addresses the relevant and applicable GWPP elements and goals described in the DOE O 450.1A technical guidance documents issued in June 2004 (DOE 2004) and May 2005 (DOE 2005). This GWPP management plan is a 'living' document that is reviewed annually, revised and reissued every three years, and is formatted to provide for updating individual sections independent of the rest of the document. Section 2 includes a short description of the groundwater system at Y-12, the history of groundwater monitoring at Y-12 and the corresponding evolution of the GWPP, and an overview of ongoing Y-12 groundwater monitoring activities. Section 3 describes the key elements of the GWPP management strategy. Organizational roles and responsibilities of GWPP personnel are outlined in Section 4. Section 5 presents an overview of the GWPP project plans for applicable programmatic elements. Section 6 lists the reports, plans, and documents that are referenced for technical and administrative details.« less

Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy

PubMed Central

Zheng, Shu; Xiao, Zuo-Xiang; Pan, Yue-Long; Han, Ming-Yong; Dong, Qi

2003-01-01

AIM: To explore the anti-tumor immunity against CT26 colon tumor of the microencapsulated cells modified with murine interleukine-12 (mIL-12) gene. METHODS: Mouse fibroblasts (NIH3T3) were stably transfected to express mIL-12 using expression plasmids carrying mIL-12 gene (p35 and p40), and NIH3T3-mIL-12 cells were encapsulated in alginate microcapsules for long-term delivery of mIL-12. mIL-12 released from the microencapsulated NIH3T3-mIL-12 cells was confirmed using ELISA assay. Transplantation of the microencapsulated NIH3T3-mIL-12 cells was performed in the tumor-bearing mice with CT26 cells. The anti-tumor responses and the anti-tumor activities of the microencapsulated NIH3T3-mIL-12 cells were evaluated. RESULTS: Microencapsulated NIH3T3-mIL-12 cells could release mIL-12 continuously and stably for a long time. After the microencapsulated NIH3T3-mIL-12 cells were transplanted subcutaneously into the tumor-bearing mice for 21 d, the serum concentrations of mIL-12, mIL-2 and mIFN-γ, the cytotoxicity of the CTL from the splenocytes and the NK activity in the treatment group were significantly higher than those in the controls. Moreover, mIL-12 released from the microencapsulated NIH3T3-mIL-12 cells resulted in a significant inhibition of tumor proliferation and a prolonged survival of tumor-bearing mice. CONCLUSION: The microencapsulated NIH3T3-mIL-12 cells have a significant therapeutic effect on the experimental colon tumor by activating anti-tumor immune responses in vivo. Microencapsulated and genetically engineered cells may be an extremely versatile tool for tumor gene therapy. PMID:12717836

Chronology and volcanology of the 1949 multi-vent rift-zone eruption on La Palma (Canary Islands)

NASA Astrophysics Data System (ADS)

Klügel, A.; Schmincke, H.-U.; White, J. D. L.; Hoernle, K. A.

1999-12-01

The compositionally zoned San Juan eruption on La Palma emanated from three eruptive centers located along a north-south-trending rift zone in the south of the island. Seismic precursors began weakly in 1936 and became strong in March 1949, with their foci progressing from the north of the rift zone towards its south. This suggests that magma ascended beneath the old Taburiente shield volcano and moved southward along the rift. The eruption began on June 24, 1949, with phreatomagmatic activity at Duraznero crater on the ridgetop (ca. 1880 m above sea level), where five vents erupted tephritic lava along a 400-m-long fissure. On June 8, the Duraznero vents shut down abruptly, and the activity shifted to an off-rift fissure at Llano del Banco, located at ca. 550 m lower elevation and 3 km to the northwest. This eruptive center issued initially tephritic aa and later basanitic pahoehoe lava at high rates, producing a lava flow that entered the sea. Two days after basanite began to erupt at Llano del Banco, Hoyo Negro crater (ca. 1880 m asl), located 700 m north of Duraznero along the rift, opened on July 12 and produced ash and bombs of basanitic to phonotephritic composition in violent phreatomagmatic explosions ( White and Schmincke, 1999). Llano del Banco and Hoyo Negro were simultaneously active for 11 days and showed a co-variance of their eruption rates indicating a shallow hydraulic connection. On July 30, after 3 days of quiescence at all vents, Duraznero and Hoyo Negro became active again during a final eruptive phase. Duraznero issued basanitic lava at high rates for 12 h and produced a lava flow that descended towards the east coast. The lava contains ca. 1 vol.% crustal and mantle xenoliths consisting of 40% tholeiitic gabbros from the oceanic crust, 35% alkaline gabbros, and 20% ultramafic cumulates. The occurrence of xenoliths almost exclusively in the final lava is consistent with their origin by wall-rock collapse at depth near the end of the eruption. The volcanic evolution of the 1949 eruption is typical of La Palma eruptions generally. Considerable shallow magma migration prior to and during eruption is manifested by strong seismicity, intense faulting, and the almost unpredictable opening of specific vents which can be spaced three or more km apart.

12 CFR 308.173 - Prevailing party.

Code of Federal Regulations, 2010 CFR

2010-01-01

... action. (b) Segregation of costs. When a proceeding has presented a number of discrete substantive issues... connection with the discrete significant substantive issue or issues on which the applicant's position has...

12 CFR 615.5010 - Funding Corporation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Funding Corporation. 615.5010 Section 615.5010... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Funding § 615.5010 Funding Corporation. (a) The Funding Corporation shall issue, market, and handle the obligations of the banks issued under section 4.2(b) through...

12 CFR 615.5010 - Funding Corporation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Funding Corporation. 615.5010 Section 615.5010... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Funding § 615.5010 Funding Corporation. (a) The Funding Corporation shall issue, market, and handle the obligations of the banks issued under section 4.2(b) through...

12 CFR 615.5010 - Funding Corporation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Funding Corporation. 615.5010 Section 615.5010... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Funding § 615.5010 Funding Corporation. (a) The Funding Corporation shall issue, market, and handle the obligations of the banks issued under section 4.2(b) through...

12 CFR 615.5010 - Funding Corporation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Funding Corporation. 615.5010 Section 615.5010... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Funding § 615.5010 Funding Corporation. (a) The Funding Corporation shall issue, market, and handle the obligations of the banks issued under section 4.2(b) through...

12 CFR 615.5010 - Funding Corporation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Funding Corporation. 615.5010 Section 615.5010... POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Funding § 615.5010 Funding Corporation. (a) The Funding Corporation shall issue, market, and handle the obligations of the banks issued under section 4.2(b) through...

Achieving Standards in a Fiber Optic Mathematics Classroom.

ERIC Educational Resources Information Center

Zbiek, Rose Mary; Foletta, Gina M.

1995-01-01

In response to standards set by the National Council of Teachers of Mathematics, K-12 teachers were interviewed to investigate issues related to implementing standards in K-12 fiber optic mathematics classes. Issues include: achieving student-centered classrooms; incorporating technology into distance education; and structuring assessment so more…

Novel Three-Dimensional Semiconducting Materials Based on Hybrid d10 Transition Metal Halogenides as Visible Light-Driven Photocatalysts.

PubMed

Yue, Cheng-Yang; Hu, Bing; Lei, Xiao-Wu; Li, Rui-Qing; Mi, Fu-Qi; Gao, Hui; Li, Yan; Wu, Fan; Wang, Chun-Lei; Lin, Na

2017-09-18

The development of new visible light-driven photocatalysts based on semiconducting materials remains a greatly interesting and challenging task for the purpose of solving the energy crisis and environmental issues. By using photosensitive [(Me) 2 -2,2'-bipy] 2+ (1,1'-dimethyl-2,2'-bipyridinium) cation as template, we synthesized one new type of inorganic-organic hybrid cuprous and silver halogenides of [(Me) 2 -2,2'-bipy]M 8 X 10 (M = Cu, Ag, X = Br, I). The compounds feature a three-dimensional anionic [M 8 X 10 ] 2- network composed of a one-dimensional [M 8 X 12 ] chain based on MX 4 tetrahedral units. The photosensitization of organic cationic templates results in narrow band gaps of hybrid compounds (1.66-2.06 eV), which feature stable visible light-driven photodegradation activities for organic pollutants. A detailed study of the photocatalytic mechanism, including the photoelectric response, photoluminescence spectra, and theoretical calculations, shows that the organic cationic template effectively inhibits the recombination of photoinduced electron-hole pairs leading to excellent photocatalytic activities and photochemical stabilities.

The EDUTECH Report, 1997-1998.

ERIC Educational Resources Information Center

EDUTECH Report, 1998

1998-01-01

This document consists of 12 issues of the EDUTECH Report. 1998. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also contain brief quotations on…

The EDUTECH Report, 2000-2001.

ERIC Educational Resources Information Center

Warger, Thomas, Ed.

2001-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also contain brief…

The EDUTECH Report, 1998-1999.

ERIC Educational Resources Information Center

EDUTECH Report, 1999

1999-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also contain brief…

The EDUTECH Report, 1999-2000.

ERIC Educational Resources Information Center

EDUTECH Report, 2000

2000-01-01

This document consists of the 12 issues, an entire volume year, of the 1999-2000 EDUTECH Report. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two or three articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also…

The reliability and validity of fatigue measures during multiple-sprint work: an issue revisited.

PubMed

Glaister, Mark; Howatson, Glyn; Pattison, John R; McInnes, Gill

2008-09-01

The ability to repeatedly produce a high-power output or sprint speed is a key fitness component of most field and court sports. The aim of this study was to evaluate the validity and reliability of eight different approaches to quantify this parameter in tests of multiple-sprint performance. Ten physically active men completed two trials of each of two multiple-sprint running protocols with contrasting recovery periods. Protocol 1 consisted of 12 x 30-m sprints repeated every 35 seconds; protocol 2 consisted of 12 x 30-m sprints repeated every 65 seconds. All testing was performed in an indoor sports facility, and sprint times were recorded using twin-beam photocells. All but one of the formulae showed good construct validity, as evidenced by similar within-protocol fatigue scores. However, the assumptions on which many of the formulae were based, combined with poor or inconsistent test-retest reliability (coefficient of variation range: 0.8-145.7%; intraclass correlation coefficient range: 0.09-0.75), suggested many problems regarding logical validity. In line with previous research, the results support the percentage decrement calculation as the most valid and reliable method of quantifying fatigue in tests of multiple-sprint performance.

PCA Based Stress Monitoring of Cylindrical Specimens Using PZTs and Guided Waves

PubMed Central

Mujica, Luis; Ruiz, Magda; Camacho, Johanatan

2017-01-01

Since mechanical stress in structures affects issues such as strength, expected operational life and dimensional stability, a continuous stress monitoring scheme is necessary for a complete integrity assessment. Consequently, this paper proposes a stress monitoring scheme for cylindrical specimens, which are widely used in structures such as pipelines, wind turbines or bridges. The approach consists of tracking guided wave variations due to load changes, by comparing wave statistical patterns via Principal Component Analysis (PCA). Each load scenario is projected to the PCA space by means of a baseline model and represented using the Q-statistical indices. Experimental validation of the proposed methodology is conducted on two specimens: (i) a 12.7 mm (1/2″) diameter, 0.4 m length, AISI 1020 steel rod, and (ii) a 25.4 mm (1″) diameter, 6m length, schedule 40, A-106, hollow cylinder. Specimen 1 was subjected to axial loads, meanwhile specimen 2 to flexion. In both cases, simultaneous longitudinal and flexural guided waves were generated via piezoelectric devices (PZTs) in a pitch-catch configuration. Experimental results show the feasibility of the approach and its potential use as in-situ continuous stress monitoring application. PMID:29194384

NtKRP, a kinesin-12 protein, regulates embryo/seed size and seed germination via involving in cell cycle progression at the G2/M transition.

PubMed

Tian, Shujuan; Wu, Jingjing; Li, Fen; Zou, Jianwei; Liu, Yuwen; Zhou, Bing; Bai, Yang; Sun, Meng-Xiang

2016-10-25

Kinesins comprise a superfamily of microtubule-based motor proteins involved in essential processes in plant development, but few kinesins have been functionally identified during seed development. Especially, few kinesins that regulate cell division during embryogenesis have been identified. Here we report the functional characterization of NtKRP, a motor protein of the kinesin-12 family. NtKRP is predominantly expressed in embryos and embryonic roots. NtKRP RNAi lines displayed reductions in cell numbers in the meristematic zone, in embryonic root length, and in mature embryo and seed sizes. Furthermore, we also show that CDKA;1 binds to NtKRP at the consensus phosphorylation sites and that the decreased cell numbers in NtKRP-silenced embryos are due to a delay in cell division cycle at the G2/M transition. In addition, binding between the cargo-binding tail domain of NtKRP and CDKA; 1 was also determined. Our results reveal a novel molecular pathway that regulates embryo/seed development and critical role of kinesin in temporal and spatial regulation of a specific issue of embryo developmental.

Self-broadened widths and shifts of 12C 16O 2: 4750-7000 cm -1

NASA Astrophysics Data System (ADS)

Toth, R. A.; Brown, L. R.; Miller, C. E.; Devi, V. Malathy; Benner, D. Chris

2006-10-01

In the previous paper, we report line strength measurements for 58 bands of 12CO 2 between 4550 and 7000 cm -1 [R.A. Toth, L.R. Brown, C.E. Miller, V. Malathy Devi, D. Chris Benner, J. Mol. Spectrosc., this issue, doi:10.1016/j.jms.2006.008.001.]. In the present study, self-broadenedwidth and self-induced pressure shift coefficients are determined in two intervals: (a) between 4750 and 5400 cm -1for bands of the Fermi triad (20011 ← 00001, 20012 ← 00001, 20013 ← 00001), three corresponding hot bands (21111 ← 01101, 21112 ← 01101, 21113 ← 01101) and the 01121← 00001 combination band; (b) between 6100 and 7000 cm -1 for the Fermi tetrad (30014 ← 00001, 30013 ← 00001, 30012 ← 00001, 30011 ← 00001), two associated hot bands (31113 ← 01101, 31112 ← 01101), as well as 00031 ← 00001 and its hot band 01131 ← 01101. Least-squares fits of the experimental width and pressure shift coefficients are modeled using empirical expressions: b0=exp∑ia(i)x(i) for widths where x(1)=1, x(2)=m, x(3)=m2, x(4)=m, x(5)=m4, x(6)={1}/{m}, and d0=∑ia(i)x(i) for pressure shifts where x(1)=1, x(2)={1}/{m}, x(3)=m, x(4)=m2, x(5)={1}/{m2}, x(6)={1}/{m3},x(7)=m3, x(8)={m}/{m} The modeled width coefficients generally agree with the experimental values with standard deviations of less than 1%, while the standard deviations of the modeled values for the pressure-induced shift coefficients range between 2.3% and 6.7%. The largest percentage error is associated with the system of the three hot bands: 21111 ← 01101, 21112 ← 01101, and 21113 ← 01101. It is observed that transitions with the same rotational quantum numbers have slightly different widths in some of the bands. As expected, pressure-induced-shift coefficients vary as a function of the band center, but there are also subtle differences from band to band for transitions with the same rotational quanta.

EDITORIAL: Strongly correlated electron systems Strongly correlated electron systems

NASA Astrophysics Data System (ADS)

Ronning, Filip; Batista, Cristian

2011-03-01

Strongly correlated electrons is an exciting and diverse field in condensed matter physics. This special issue aims to capture some of that excitement and recent developments in the field. Given that this issue was inspired by the 2010 International Conference on Strongly Correlated Electron Systems (SCES 2010), we briefly give some history in order to place this issue in context. The 2010 International Conference on Strongly Correlated Electron Systems was held in Santa Fe, New Mexico, a reunion of sorts from the 1989 International Conference on the Physics of Highly Correlated Electron Systems that also convened in Santa Fe. SCES 2010—co-chaired by John Sarrao and Joe Thompson—followed the tradition of earlier conferences, in this century, hosted by Buzios (2008), Houston (2007), Vienna (2005), Karlsruhe (2004), Krakow (2002) and Ann Arbor (2001). Every three years since 1997, SCES has joined the International Conference on Magnetism (ICM), held in Recife (2000), Rome (2003), Kyoto (2006) and Karlsruhe (2009). Like its predecessors, SCES 2010 topics included strongly correlated f- and d-electron systems, heavy-fermion behaviors, quantum-phase transitions, non-Fermi liquid phenomena, unconventional superconductivity, and emergent states that arise from electronic correlations. Recent developments from studies of quantum magnetism and cold atoms complemented the traditional subjects and were included in SCES 2010. 2010 celebrated the 400th anniversary of Santa Fe as well as the birth of astronomy. So what's the connection to SCES? The Dutch invention of the first practical telescope and its use by Galileo in 1610 and subsequent years overturned dogma that the sun revolved about the earth. This revolutionary, and at the time heretical, conclusion required innovative combinations of new instrumentation, observation and mathematics. These same combinations are just as important 400 years later and are the foundation of scientific discoveries that were discussed during SCES 2010. As we learned, past dogmas about strongly correlated materials and phenomena must be re-examined with an open and inquisitive mind. Invited speakers and respected leaders in the field were invited to contribute to this special issue and we have insisted that they present new data, ideas, or perspectives, as opposed to simply an overview of their past work. As with the conference, this special issue touches upon recent developments of strongly correlated electron systems in d-electron materials, such as Sr3Ru2O7, graphene, and the new Fe-based superconductors, but it is dominated by topics in f-electron compounds. Contributions reflect the growing appreciation for the influence of disorder and frustration, the need for organizing principles, as well as detailed investigations on particular materials of interest and, of course, new materials. As this special issue could not possibly capture the full breadth and depth that the conference had to offer, it is being published simultaneously with an issue of Journal of Physics: Conference Series containing 157 manuscripts in which all poster presenters at SCES 2010 were invited to contribute. Since this special issue grew out of the 2010 SCES conference, we take this opportunity to give thanks. This conference would not have been possible without the hard work of the SCES 2010 Program Committee, International and National Advisory Committees, Local Committee, and conference organizers, the New Mexico Consortium. We thank them as well as those organizations that generously provided financial support: ICAM-I2CAM, Quantum Design, Lakeshore, the National High Magnetic Field Laboratory and the Department of Energy National Laboratories at Argonne, Berkeley, Brookhaven, Los Alamos and Oak Ridge. Of course, we especially thank the participants for bringing new ideas and new results, without which SCES 2010 would not have been possible. Strongly correlated electron systems contents Spin-orbit coupling and k-dependent Zeeman splitting in strontium ruthenate Emil J Rozbicki, James F Annett, Jean-René Souquet and Andrew P Mackenzie Thermodynamics of itinerant metamagnetic transitions A M Berridge Magnon-mediated pairing and isotope effect in iron-based superconductors Jiansheng Wu and Philip Phillips Nernst quantum oscillations in bulk semi-metals Zengwei Zhu, Huan Yang, Aritra Banerjee, Liam Malone, Benoît Fauqué and Kamran Behnia Signatures of a quantum Griffiths phase in a d-metal alloy close to its ferromagnetic quantum critical point Almut Schroeder, Sara Ubaid-Kassis and Thomas Vojta Influence of super-ohmic dissipation on a disordered quantum critical point Thomas Vojta, José A Hoyos, Priyanka Mohan and Rajesh Narayanan The van Hemmen-Kondo model for disordered cerium systems S G Magalhaes, F M Zimmer and B Coqblin Chemical pressure, dilution and disorder in the heavy fermion compounds Ce3 - xLaxPd20Si6 (x = 1/3, 2/3) H Winkler, K-A Lorenzer, S Laumann, J Custers, A Prokofiev and S Paschen Magnetism of fine particles of Kondo lattices, obtained by high-energy ball-milling E V Sampathkumaran, K Mukherjee, Kartik K Iyer, Niharika Mohapatra and Sitikantha D Das Heavy fermion scaling: uranium versus cerium and ytterbium compounds J M Lawrence, C H Wang, A D Christianson and E D Bauer Temperature dependence of hybridization gaps in metallic heavy-fermion systems Xiaodong Yang, Peter S Riseborough and Tomasz Durakiewicz Low-energy properties of the Kondo lattice model O Bodensiek, R Žitko, R Peters and T Pruschke Temperature dependence of the zero-bias anomaly in the Anderson-Hubbard model: insights from an ensemble of two-site systems R Wortis and W A Atkinson A charge density wave in the hidden order state of URu2Si2 Jung-Jung Su, Yonatan Dubi, Peter Wölfle and Alexander V Balatsky Field-induced suppression of the heavy-fermion state in YbRh2Si2 Gertrud Zwicknagl Discontinuous Hall coefficient at the quantum critical point in YbRh2Si2 Sven Friedemann, Niels Oeschler, Steffen Wirth, Cornelius Krellner, Christoph Geibel, Frank Steglich, Silke Paschen, Stefan Kirchner and Qimiao Si Roles of critical valence fluctuations in Ce- and Yb-based heavy fermion metals Shinji Watanabe and Kazumasa Miyake Unconventional quantum criticality in the pressure-induced heavy-fermion superconductor CeRhIn5 Tuson Park, V A Sidorov, H Lee, F Ronning, E D Bauer, J L Sarrao and J D Thompson Magnetic structure of the antiferromagnetic Fulde-Ferrell-Larkin-Ovchinnikov state Youichi Yanase and Manfred Sigrist Magnetic transition and spin fluctuations in the unconventional antiferromagnetic compound Yb3Pt4 S Zhao, D E MacLaughlin, O O Bernal, J M Mackie, C Marques, Y Janssen and M C Aronson The non-centrosymmetric heavy fermion ferromagnet Sm2Fe12P7 M Janoschek, R E Baumbach, J J Hamlin, I K Lum and M B Maple Magnetic, thermal, and transport properties of the actinide based noncentrosymmetric compounds Th2Fe12P7 and U2Fe12P7 R E Baumbach, J J Hamlin, M Janoschek, I K Lum and M B Maple Magnetic order in Pu2M3Si5 (M = Co, Ni) E D Bauer, P H Tobash, J N Mitchell, J A Kennison, F Ronning, B L Scott and J D Thompson

75 FR 57537 - Sunshine Act; Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

..., 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). * * * * * * The schedule for Commission..., 2010 1 p.m. Briefing on Resolution of Generic Safety Issue (GSI)--191, Assessment of Debris... 18, 2010 1:30 p.m. NRC All Employees Meeting (Public Meeting) Marriott Bethesda North Hotel, 5701...

76 FR 71370 - Silviu Ziscovici, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-17

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 11-3] Silviu Ziscovici, M.D.; Decision and Order On December 10, 2010, Administrative Law Judge (ALJ) Timothy D. Wing, issued the... Certificate of Registration, BZ4692756, issued to Silviu Ziscovici, M.D., be, and it hereby is, revoked. I...

49 CFR 1105.12 - Sample newspaper notices for abandonment exemption cases.

Code of Federal Regulations, 2010 CFR

2010-10-01

... original and 10 copies of any pleading that raises matters other than environmental issues (such as trails... and 10 copies of any pleading that raises matters other than environmental issues (such as trails use... OF ENVIRONMENTAL LAWS § 1105.12 Sample newspaper notices for abandonment exemption cases. In every...

12 CFR 615.5356 - Notice of intent to issue a capital directive.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Notice of intent to issue a capital directive. 615.5356 Section 615.5356 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM FUNDING AND FISCAL AFFAIRS, LOAN POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Issuance of a Capital Directive...

40 CFR 78.12 - Standard of review.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) APPEAL PROCEDURES § 78.12 Standard of review. (a) On appeal of a decision of the Administrator prior to... properly issued or should be issued. (b) On appeal of a decision of the Administrator not covered by paragraph (a) of this section, the Administrator shall have the burden of going forward to show the rational...

Defense Contracting in Iraq: Issues and Options for Congress

DTIC Science & Technology

2008-08-15

Business Board to examine these issues and report its findings within 60 days. The Fiscal Year (FY) 2008 Defense Authorization Act (P.L. 110-181...AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for...11 DOD Inspector General . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

Continuity of Operations Plans: Policy and Strategy for K-12 Schools in the State of Florida

DTIC Science & Technology

2011-12-01

issue that has emerged, as it concerns COOP, involves the need for Florida K-12 school systems to develop these plans. Florida neither requires, as is...test COOPs to ensure functional and recovery capabilities. Issues , such as alternate facilities, computer and informational services, as well as human...policy and strategy components for K-12 schools. D. HYPOTHESIS Within the communities of government, universities and businesses , a COOP has

Women in Higher Education, 1997.

ERIC Educational Resources Information Center

Wenniger, Mary Dee, Ed.

1997-01-01

The 12 issues of this newsletter focus on issues concerned with women students, faculty, and administrators in higher education. Each issue includes feature articles, news items, and profiles of significant people. The issues' main articles address: women in athletics; leadership development for women; the first year in academic administration;…

Isolation and Structural Elucidation of Antiproliferative Compounds of Lipidic Fractions from White Shrimp Muscle (Litopenaeus vannamei)

PubMed Central

López-Saiz, Carmen-María; Velázquez, Carlos; Hernández, Javier; Cinco-Moroyoqui, Francisco-Javier; Plascencia-Jatomea, Maribel; Robles-Sánchez, Maribel; Machi-Lara, Lorena; Burgos-Hernández, Armando

2014-01-01

Shrimp is one of the most popular seafood items worldwide, and has been reported as a source of chemopreventive compounds. In this study, shrimp lipids were separated by solvent partition and further fractionated by semi-preparative RP-HPLC and finally by open column chromatography in order to obtain isolated antiproliferative compounds. Antiproliferative activity was assessed by inhibition of M12.C3.F6 murine cell growth using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay. The methanolic fraction showed the highest antiproliferative activity; this fraction was separated into 15 different sub-fractions (M1–M15). Fractions M8, M9, M10, M12, and M13 were antiproliferative at 100 µg/mL and they were further tested at lower concentrations. Fractions M12 and M13 exerted the highest growth inhibition with an IC50 of 19.5 ± 8.6 and 34.9 ± 7.3 µg/mL, respectively. Fraction M12 was further fractionated in three sub-fractions M12a, M12b, and M12c. Fraction M12a was identified as di-ethyl-hexyl-phthalate, fraction M12b as a triglyceride substituted by at least two fatty acids (predominantly oleic acid accompanied with eicosapentaenoic acid) and fraction M12c as another triglyceride substituted with eicosapentaenoic acid and saturated fatty acids. Bioactive triglyceride contained in M12c exerted the highest antiproliferative activity with an IC50 of 11.33 ± 5.6 µg/mL. Biological activity in shrimp had been previously attributed to astaxanthin; this study demonstrated that polyunsaturated fatty acids are the main compounds responsible for antiproliferative activity. PMID:25526568

Direct nn-Scattering Measurement With the Pulsed Reactor YAGUAR.

PubMed

Mitchell, G E; Furman, W I; Lychagin, E V; Muzichka, A Yu; Nekhaev, G V; Strelkov, A V; Sharapov, E I; Shvetsov, V N; Chernuhin, Yu I; Levakov, B G; Litvin, V I; Lyzhin, A E; Magda, E P; Crawford, B E; Stephenson, S L; Howell, C R; Tornow, W

2005-01-01

Although crucial for resolving the issue of charge symmetry in the nuclear force, direct measurement of nn-scattering by colliding free neutrons has never been performed. At present the Russian pulsed reactor YAGUAR is the best neutron source for performing such a measurement. It has a through channel where the neutron moderator is installed. The neutrons are counted by a neutron detector located 12 m from the reactor. In preliminary experiments an instantaneous value of 1.1 × 10(18)/cm(2)s was obtained for the thermal neutron flux density. The experiment will be performed by the DIANNA Collaboration as International Science & Technology Center (ISTC) project No. 2286.

Direct nn-Scattering Measurement With the Pulsed Reactor YAGUAR

PubMed Central

Mitchell, G. E.; Furman, W. I.; Lychagin, E. V.; Muzichka, A. Yu.; Nekhaev, G. V.; Strelkov, A. V.; Sharapov, E. I.; Shvetsov, V. N.; Chernuhin, Yu. I.; Levakov, B. G.; Litvin, V. I.; Lyzhin, A. E.; Magda, E. P.; Crawford, B. E.; Stephenson, S. L.; Howell, C. R.; Tornow, W

2005-01-01

Although crucial for resolving the issue of charge symmetry in the nuclear force, direct measurement of nn-scattering by colliding free neutrons has never been performed. At present the Russian pulsed reactor YAGUAR is the best neutron source for performing such a measurement. It has a through channel where the neutron moderator is installed. The neutrons are counted by a neutron detector located 12 m from the reactor. In preliminary experiments an instantaneous value of 1.1 × 1018/cm2s was obtained for the thermal neutron flux density. The experiment will be performed by the DIANNA Collaboration as International Science & Technology Center (ISTC) project No. 2286. PMID:27308126

Absence of magnetic ordering and field-induced phase diagram in the gadolinium aluminum garnet

NASA Astrophysics Data System (ADS)

Florea, O.; Lhotel, E.; Jacobsen, H.; Knee, C. S.; Deen, P. P.

2017-12-01

The robustness of spin liquids with respect to small perturbations, and the way magnetic frustration can be lifted by slight changes in the balance between competing magnetic interactions, remains a rich and open issue. We address this question through the study of the gadolinium aluminum garnet Gd3Al5O12 , a related compound to the extensively studied Gd3Ga5O12 . We report on its magnetic properties at very low temperatures. We show that despite a freezing at about 300 mK, no magnetic transition is observed, suggesting the presence of a spin-liquid state down to the lowest temperatures, similarly to Gd3Ga5O12 , in spite of a larger ratio between exchange and dipolar interactions. Finally, the phase diagram as a function of field and temperature is strongly reminiscent of the one reported in Gd3Ga5O12 . This study reveals the robust nature of the spin-liquid phase for Gd ions on the garnet lattice, in stark contrast to Gd ions on the pyrochlore lattice for which a slight perturbation drives the compound into a range of magnetically ordered states.

Shedding light on thirteen years of darkness: content analysis of articles pertaining to transgender issues in marriage/couple and family therapy journals.

PubMed

Blumer, Markie L C; Green, Mary S; Knowles, Sarah J; Williams, April

2012-06-01

What is the extent to which marriage/couple and family therapy (M/CFT) journals address transgender issues and how many of them say they are inclusive of transgender persons when they are not? To answer these queries, a content analysis was conducted on articles published in M/CFT literature from 1997 through 2009. Of the 10,739 articles examined in 17 journals, only nine (0.0008%) focused on transgender issues or used gender variance as a variable. Findings support the assertion that transgender issues are ignored and marginalized by M/CFT scholars and researchers alike. © 2012 American Association for Marriage and Family Therapy.

78 FR 48180 - Certificate of Alternative Compliance for the M/V IRON STAN, 1246342

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-07

... Compliance for the M/V IRON STAN, 1246342 AGENCY: Coast Guard, DHS. ACTION: Notice. SUMMARY: The Coast Guard announces that a Certificate of Alternative Compliance was issued for the Uninspected Towing Vessel M/V IRON..., as allowed for under 33 U.S.C. 1605(c) and 33 CFR 81.18, has been issued for the M/V IRON STAN. The...

Ethical Issues in mHealth Research Involving Persons Living with HIV/AIDS and Substance Abuse

PubMed Central

Labrique, Alain B.; Kirk, Gregory D.; Westergaard, Ryan P.; Merritt, Maria W.

2013-01-01

We aim to raise awareness and stimulate dialogue among investigators and research ethics committees regarding ethical issues that arise specifically in the design and conduct of mHealth research involving persons living with HIV/AIDS and substance abuse. Following a brief background discussion of mHealth research in general, we offer a case example to illustrate the characteristics of mHealth research involving people living with HIV/AIDS and substance abuse. With reference to a well-established systematic general ethical framework for biomedical research with human participants, we identify a range of ethical issues that have particular salience for the protection of participants in mHealth research on HIV/AIDS and substance abuse. PMID:24171110

EDITORIAL: Cluster issue on Heusler compounds and devices Cluster issue on Heusler compounds and devices

NASA Astrophysics Data System (ADS)

Felser, Claudia; Hillebrands, Burkard

2009-04-01

This is the third cluster issue of Journal Physics D: Applied Physics devoted to half-metallic Heusler compounds and devices utilizing this class of materials. Heusler compounds are named after Fritz Heusler, the owner of a German copper mine, the Isabellenhütte, who discovered this class of materials in 1903 [1]. He synthesized mixtures of Cu2Mn alloys with various main group metals Z = Al, Si, Sn, Sb, which became ferromagnetic despite all constituents being non-magnetic. The recent success story of Heusler compounds began in 1983 with the discovery of the half-metallic electronic structure in NiMnSb [2] and Co2MnZ [3], making these and similar materials, in particular PtMnSb, also useful for magneto-optical data storage media applications due to their high Kerr rotation. The real breakthrough, however, came in 2000 with the observation of a large magnetoresistance effect in Co2Cr0.6Fe0.4Al [4]. The Co2YZ (Y = Ti, Cr, Mn, Fe) compounds are a special class of materials, which follow the Slater-Pauling rule [5], and most of them are half-metallic bulk materials. The electronic structure of Heusler compounds is well understood [6] and Curie temperatures up to 1100 K have been observed [7]. In their contribution to this cluster issue, Thoene et al predict that still higher Curie temperatures can be achieved. A breakthrough from the viewpoint of materials design is the synthesis of nanoparticles of Heusler compounds as reported in the contribution by Basit et al. Nano-sized half- metallic ferromagnets will open new directions for spintronic applications. The challenge, however, is still to produce spintronic devices with well defined interfaces to take advantage of the half-metallicity of the electrodes. Several groups have succeeded in producing excellent tunnel junctions with high magnetoresistance effects at low temperatures and decent values at room temperature [8-11]. Spin-dependent tunnelling characteristics of fully epitaxial magnetic tunnel junctions with a Heusler alloy can be used to obtain information about the half-metallicity and the magnons as reported by Taira et al in this issue. An improvement of the tunnel magnetoresistance effect (TMR) at room temperature could be achieved by shifting the Fermi energy from the edges of the valence or the conduction band into the middle of the gap [12]. In the case of Co2FeSi0.5Al0.5 (CFAS), TMR values higher than 200% can be achieved [13]. The improvement of the interface seems to be important as has been shown by XMCD (x-ray magnetic circular dichroism) [14] and photoemission spectroscopy [15]. The interface magnetization is very often reduced [14]; however, the interface and the surface electron spin polarization can be improved by post annealing as reported by Wüstenberg et al in this issue. High energy photoemission spectroscopy is a new tool for investigating bulk properties of Heusler compounds [16]. In this issue we report on the investigation of a whole device structure by this technique due to the high escape depth inherent to this method in the contribution of Herbort et al. Dynamic correlations might be a reason for the formation of non-quasi-particles such as magnons in the gap [17], which destroy the half-metallicity and thus can be considered as another cause for the reduced TMR at room temperature. Thus correlations have to be taken into account. This is demonstrated for the Heusler compound Co2Mn1 - xFexSi as reported by Chadov et al in this issue. Magneto-optic methods are powerful instruments for investigating magnetic properties of Heusler compounds. The determination of the huge quadratic Kerr effect in the Co2FeSi Heusler compound is a good example [18]. In this issue Hamrle et al and Gaier et al report on the determination of the exchange constant by measuring the magnon dispersion properties using Brillouin light scattering spectroscopy. The magnon dispersion was calculated by Thoene et al. New developments in the field of spintronics go into the direction of the spin-Hall effect, spin-torque investigations and CPP GMR (current perpendicular plane giant magnetoresistance). Schneider et al have studied the Hall effect of laser ablated Co2(MnFe)Si thin films. Recently Inomata's group has reported on a high CPP GMR effect based on CFSA [19]. In this issue a theoretical study by Dai et al reports on the interfaces between CCFA and very thin chromium layers. Here the interface stays half-metallic which is a promising result regarding the realization of potential GMR devices. For spin-torque applications special requirements concerning the materials are necessary. Low damping constants, low magnetic moments and a perpendicular anisotropy are favourable properties. Ferrimagnetic Heusler compounds are candidates for low magnetic moments despite a high spin polarization and a high Curie temperature [20, 21]. Mn3Ga shows additionally a tetragonal distortion, which is favourable for perpendicular anisotropy [21]. The stability of Heusler compounds versus structural distortion is a well known phenomenon in shape memory alloys [22]. We hope this cluster of papers will inspire many researchers in the field of spintronics and motivate some of them to use these advanced materials for new devices. References [1] Heusler F 1903 Verh. Dtsch. Phys. Ges. 12 219 [2] de Groot R A, Müller F M, van Engen P G and Buschow K H J 1983 Phys. Rev. Lett. 50 2024 [3] Kübler J, Williams A R, Sommers C B 1983 Phys. Rev. B 28 1745 [4] Block T, Felser C and Jakob G 2003 J. Solid State Chem. 176 646 [5] Galanakis I, Mavropoulos Ph and Dederichs P H 2006 J. Phys. D: Appl. Phys. 39 765 [6] Kandpal H C, Fecher G H and Felser C 2007 J. Phys. D: Appl. Phys. 40 1507 [7] Wurmehl S, Fecher G H, Kandpal H C, Ksenofontov V, Felser C and Lin H J 2006 Appl. Phys. Lett. 86 032503 [8] Kämmerer S, Thomas A, Hütten A and Reiss G 2004 Appl. Phys. Lett. 85 79 [9] Yamato M, Marukame T, Ishikawa T, Matsuda K, Uemura T and Arita M 2006 J. Phys. D: Appl. Phys. 39 824 [10] Sakuraba Y, Hattori M, Oogane M, Ando Y, Kato H, Sakuma A, Miyazaki T and Kubota H 2006 Appl. Phys. Lett. 88 192508 [11] Inomata K, Okamura S, Miyazaki A, Kikuchi M, Tezuka N, Wojcik M and Jedryka E 2006 J. Phys. D: Appl. Phys. 39 816 [12] Fecher G H and Felser C 2007 J. Phys. D: Appl. Phys. 40 1582 [13] Tezuka N, Ikeda N, Miyazaki A, Sugimoto S, Kikuchi M and Inomata K 2006 Appl. Phys. Lett. 89 112514 [14] Kallmayer M, Schneider H, Jakob G, Elmers H J, Balke B and Cramm S 2007 J. Phys. D: Appl. Phys. 40 1552 [15] Cinchetti M, Wüstenberg J P, Sánchez Albaneda M, Steeb F, Conca A, Jourdan M and Aeschlimann M 2007 J. Phys. D: Appl. Phys. 40 1544 [16] Fecher G H, Balke B, Ouardi S, Felser C, Schonhense G, Ikenaga E, Kim J J, Ueda S and Kobayashi K 2007 J. Phys. D: Appl. Phys. 40 1576 [17] Chioncel L, Sakuraba Y, Arrigoni E, Katsnelson M I, Oogane M, Ando Y, Miyazaki T, Burzo E and Lichtenstein A I 2008 Phys. Rev. Lett. 100 086402 [18] Hamrle J, Blomeier S, Gaier O, Hillebrands B, Schneider H, Jakob G, Postava K and Felser C 2007 J. Phys. D: Appl. Phys. 40 1563 [19] Furubayashi T, Kodama K, Sukegawa H, Takahashi Y K, Inomata K and Hono K 2008 Appl. Phys. Lett. 93 122507 [20] Balke B, Fecher G H, Winterlik J and Felser C 2007 Appl. Phys. Lett. 90 152504 [21] Wurmehl S, Kandpal H C, Fecher G H and Felser C 2006 J. Phys.: Cond. Mat. 18 6171 [22] Entel P, Bucheinikov V D, Khovailo V V, Zayak A T, Adeagbo W A, Gruner M E, Herper H C and Wassermann E F 2006 J. Phys. D: Appl. Phys. 39 865

Centennial State Libraries, 1998.

ERIC Educational Resources Information Center

Parent, Kathleen D., Ed.

1998-01-01

This document consists of 12 consecutive issues of the monthly "Centennial State Libraries" newsletter, of the Colorado Department of Education, State Library and Adult Education Office. The issues cover the year 1998. Each issue of the newsletter--except the August issue which is an Annual Report--includes some or all of the following…

12 CFR 747.604 - Standards for award.

Code of Federal Regulations, 2010 CFR

2010-01-01

... discrete substantive portion of the proceeding, by or against NCUA unless the position of NCUA during the... one or more discrete substantive issues in a proceeding, even though all the issues were not resolved... discrete significant substantive issue or issues on which the applicant's position has been upheld. If such...

The EDUTECH Report, 2002-2003.

ERIC Educational Resources Information Center

Warger, Thomas, Ed.

2003-01-01

This document consists of 12 issues, an entire volume year, of "The EDUTECH Report." The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, and a question and answer column. Most issues also contain brief quotations on education…

Women in Higher Education, 1994.

ERIC Educational Resources Information Center

Wenninger, Mary Dee, Ed.

1994-01-01

This document consists of the 12 monthly issues of a newsletter on women students, teachers, and administrators in higher education, issued in 1994. Each issue includes feature articles, news on higher education, profiles of significant people in the field, and job announcements. The issues' main article topics are: (1) campuses's changing…

The EDUTECH Report, 2001-2002.

ERIC Educational Resources Information Center

Warger, Thomas, Ed.

2002-01-01

This document consists of 12 issues of the "EDUTECH Report." The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, and a question and answer column. Issues also contain brief quotations on education technology topics. The…

HCN Survey of Normal Spiral, Infrared-luminous, and Ultraluminous Galaxies

NASA Astrophysics Data System (ADS)

Gao, Yu; Solomon, Philip M.

2004-05-01

We report systematic HCN J=1-0 (and CO) observations of a sample of 53 infrared (IR) and/or CO-bright and/or luminous galaxies, including seven ultraluminous infrared galaxies, nearly 20 luminous infrared galaxies, and more than a dozen of the nearest normal spiral galaxies. This is the largest and most sensitive HCN survey of galaxies to date. All galaxies observed so far follow the tight correlation between the IR luminosity LIR and the HCN luminosity LHCN initially proposed by Solomon, Downes, & Radford, which is detailed in a companion paper. We also address here the issue of HCN excitation. There is no particularly strong correlation between LHCN and the 12 μm luminosity; in fact, of all the four IRAS bands, the 12 μm luminosity has the weakest correlation with the HCN luminosity. There is also no evidence of stronger HCN emission or a higher ratio of HCN and CO luminosities LHCN/LCO for galaxies with excess 12 μm emission. This result implies that mid-IR radiative pumping, or populating, of the J=1 level of HCN by a mid-IR vibrational transition is not important compared with the collisional excitation by dense molecular hydrogen. Furthermore, large velocity gradient calculations justify the use of HCN J=1-0 emission as a tracer of high-density molecular gas (>~3×104/τcm-3) and give an estimate of the mass of dense molecular gas from HCN observations. Therefore, LHCN may be used as a measure of the total mass of dense molecular gas, and the luminosity ratio LHCN/LCO may indicate the fraction of molecular gas that is dense.

12 CFR 925.21 - Issuance and form of stock.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Issuance and form of stock. 925.21 Section 925... ASSOCIATES MEMBERS OF THE BANKS Stock Requirements § 925.21 Issuance and form of stock. (a) A Bank shall... stock shall be issued in installments with the appropriate number of shares issued after each payment is...

22 CFR 19.6-4 - Date of court orders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Department if it is issued more than 12 months after the divorce becomes final. A court order adjusting the... order issued within 12 months after a divorce becomes final directing payment of a pension to a former... month in which the divorce becomes final if so specified by the court. In such event, the Department...

22 CFR 19.6-4 - Date of court orders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Department if it is issued more than 12 months after the divorce becomes final. A court order adjusting the... order issued within 12 months after a divorce becomes final directing payment of a pension to a former... month in which the divorce becomes final if so specified by the court. In such event, the Department...

22 CFR 19.6-4 - Date of court orders.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Department if it is issued more than 12 months after the divorce becomes final. A court order adjusting the... order issued within 12 months after a divorce becomes final directing payment of a pension to a former... month in which the divorce becomes final if so specified by the court. In such event, the Department...

22 CFR 19.6-4 - Date of court orders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Department if it is issued more than 12 months after the divorce becomes final. A court order adjusting the... order issued within 12 months after a divorce becomes final directing payment of a pension to a former... month in which the divorce becomes final if so specified by the court. In such event, the Department...

22 CFR 19.6-4 - Date of court orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Department if it is issued more than 12 months after the divorce becomes final. A court order adjusting the... order issued within 12 months after a divorce becomes final directing payment of a pension to a former... month in which the divorce becomes final if so specified by the court. In such event, the Department...

THINGS: THE H I NEARBY GALAXY SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walter, Fabian; Bigiel, Frank; Leroy, Adam

2008-12-15

We present 'The H I Nearby Galaxy Survey (THINGS)', a high spectral ({<=}5.2 km s{sup -1}) and spatial ({approx}6'') resolution survey of H I emission in 34 nearby galaxies obtained using the NRAO Very Large Array (VLA). The overarching scientific goal of THINGS is to investigate fundamental characteristics of the interstellar medium (ISM) related to galaxy morphology, star formation, and mass distribution across the Hubble sequence. Unique characteristics of the THINGS database are the homogeneous sensitivity as well as spatial and velocity resolution of the H I data, which is at the limit of what can be achieved with themore » VLA for a significant number of galaxies. A sample of 34 objects at distances 2 {approx}< D {approx}< 15 Mpc (resulting in linear resolutions of {approx}100 to 500 pc) are targeted in THINGS, covering a wide range of star formation rates ({approx}10{sup -3} to 6 M{sub sun} yr{sup -1}), total H I masses M{sub HI} (0.01 to 14 x 10{sup 9} M{sub sun}), absolute luminosities M{sub B} (-11.5 to -21.7 mag), and metallicities (7.5 to 9.2 in units of 12+log[O/H]). We describe the setup of the VLA observations, the data reduction procedures, and the creation of the final THINGS data products. We present an atlas of the integrated H I maps, the velocity fields, the second moment (velocity dispersion) maps and individual channel maps of each THINGS galaxy. The THINGS data products are made publicly available through a dedicated webpage. Accompanying THINGS papers (in this issue of the Astronomical Journal) address issues such as the small-scale structure of the ISM, the (dark) matter distribution in THINGS galaxies, and the processes leading to star formation.« less

Lasing characteristics of refractive-index-matched composite Y3Al5O12 rods employing transparent ceramics for solar-pumped lasers

NASA Astrophysics Data System (ADS)

Hasegawa, Kazuo; Ichikawa, Tadashi; Takeda, Yasuhiko; Ikesue, Akio; Ito, Hiroshi; Motohiro, Tomoyoshi

2018-04-01

We have proposed a new configuration of solar-pumped lasers employing transparent ceramic rods. The laser rod has a composite structure consisting of a Nd/Cr:YAG gain domain surrounded by Gd:YAG with the same refractive index as that of Nd/Cr:YAG. The lasing mode is well controlled by the output coupler, and the parasitic oscillation is suppressed, owing to the refractive index matching. A high laser slope efficiency and a low laser oscillation threshold were achieved owing to the suppressed absorption outside the lasing mode, which was previously a serious issue for the end-pumping configuration using a high-NA focusing optics. The laser oscillation threshold of 136 mW and the slope efficiency of 25.3% were derived. Thus, we have resolved the issue of useless absorption associated with the high-NA end-pumping, and achieved significant improvements compared with the conventional structure of uniform Nd/Cr:YAG.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elvado Environmental LLC; Environmental Compliance Department Environment, Safety, and Health Division Y-12 National Security Complex

This document presents the Groundwater Protection Program (GWPP) management plan for the U.S. Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12). The Y-12 GWPP functions as the primary point-of-contact for groundwater-related issues at Y-12, provides stewardship of the extensive network of groundwater monitoring wells at Y-12, and serves as a resource for technical expertise, support, and historical data for groundwater-related activities at Y-12. These organizational functions each serve the primary programmatic purpose of the GWPP, which is to ensure that groundwater monitoring activities within areas under Y-12 administrative control provide representative data in compliance with themore » multiple purposes of applicable state and federal regulations, DOE orders, and the corporate policies of BWXT Y-12, L.L.C. (hereafter referenced as BWXT), the Y-12 management and operations (M&O) contractor for DOE. This GWPP management plan addresses the requirements of DOE Order 450.1 (BWXT Y12 S/RID) regarding the implementation of a site-wide approach for groundwater protection at each DOE facility. Additionally, this plan is a ''living'' document that is reviewed annually, revised and reissued every three years, and is formatted to provide for updating individual sections independent of the rest of the document. Section 2 includes a short description of the groundwater system at Y-12, the history of groundwater monitoring at Y-12 and the corresponding evolution of the GWPP, and an overview of ongoing Y-12 groundwater monitoring activities. Section 3 describes the key elements of the GWPP management strategy. Organizational roles and responsibilities of GWPP personnel are outlined in Section 4. Section 5 presents an overview of the GWPP project plans for applicable programmatic elements. Section 6 lists the reports, plans, and documents that are referenced for technical and administrative details.« less

Evaluation of TanDEM-X DEMs on selected Brazilian sites: Comparison with SRTM, ASTER GDEM and ALOS AW3D30

NASA Astrophysics Data System (ADS)

Grohmann, Carlos H.

2018-06-01

A first assessment of the TanDEM-X DEMs over Brazilian territory is presented through a comparison with SRTM, ASTER GDEM and ALOS AW3D30 DEMs in seven study areas with distinct geomorphological contexts, vegetation coverage and land use. Visual analysis and elevation histograms point to a finer effective spatial resolution of TanDEM-X compared to SRTM and ASTER GDEM. In areas of open vegetation, TanDEM-X lower elevations indicate a better penetration of the radar signal. DEMs of differences (DoDs) allowed the identification of issues inherent to the production methods of the analyzed DEMs, such as mast oscillations in SRTM data and mismatch between adjacent scenes in ASTER GDEM and ALOS AW3D30. A systematic difference in elevations between TanDEM-X 12m, TanDEM-X 30m and SRTM was observed in the steep slopes of the coastal ranges, related to the moving-window process used to resample the 12m data to a 30m pixel size. Due its simplicity, it is strongly recommended to produce a DoD with SRTM before using ASTER GDEM or ALOS AW3D30 in any analysis, to evaluate if the area of interest is affected by these problems. The DoDs also highlighted changes in land use in the time span between the acquisition of SRTM (2000) and TanDEM-X (2013) data, whether by natural causes or by human interference in the environment.

Ethical acceptability of offering financial incentives for taking antipsychotic depot medication: patients' and clinicians' perspectives after a 12-month randomized controlled trial.

PubMed

Noordraven, Ernst L; Schermer, Maartje H N; Blanken, Peter; Mulder, Cornelis L; Wierdsma, André I

2017-08-29

A randomized controlled trial 'Money for Medication'(M4M) was conducted in which patients were offered financial incentives for taking antipsychotic depot medication. This study assessed the attitudes and ethical considerations of patients and clinicians who participated in this trial. Three mental healthcare institutions in secondary psychiatric care in the Netherlands participated in this study. Patients (n = 169), 18-65 years, diagnosed with schizophrenia, schizoaffective disorder or another psychotic disorder who had been prescribed antipsychotic depot medication, were randomly assigned to receive 12 months of either treatment as usual plus a financial reward for each depot of medication received (intervention group) or treatment as usual alone (control group). Structured questionnaires were administered after the 12-month intervention period. Data were available for 133 patients (69 control and 64 intervention) and for 97 clinicians. Patients (88%) and clinicians (81%) indicated that financial incentives were a good approach to improve medication adherence. Ethical concerns were categorized according to the four-principles approach (autonomy, beneficence, non-maleficence, and justice). Patients and clinicians alike mentioned various advantages of M4M in clinical practice, such as increased medication adherence and improved illness insight; but also disadvantages such as reduced intrinsic motivation, loss of autonomy and feelings of dependence. Overall, patients evaluated financial incentives as an effective method of improving medication adherence and were willing to accept this reward during clinical treatment. Clinicians were also positive about the use of this intervention in daily practice. Ethical concerns are discussed in terms of patient autonomy, beneficence, non-maleficence and justice. We conclude that this intervention is ethically acceptable under certain conditions, and that further research is necessary to clarify issues of benefit, motivation and the preferred size and duration of the incentive. Nederlands Trial Register, number NTR2350 .

Contemporary Environmental Issues: Creating Curricular Connections in K-12 Education.

ERIC Educational Resources Information Center

Dass, Pradeep Maxwell

1999-01-01

Trans-disciplinary educational approaches hold the promise of helping students see real-life issues in an organic rather than a fragmented manner and be able to apply knowledge to address these issues in an organic manner. Presents reasons for organizing trans-disciplinary instruction around contemporary environmental issues. (Contains 14…

The Socio-Scientific Reasoning Model: Instruments for Evaluation.

ERIC Educational Resources Information Center

Cheu, Janey; And Others

The Environmental Issues Test (EIT) is an instrument designed to assess moral and ethical reasoning within a scientific or technological context. It is comprised of five dilemma stories each of which highlights an environmental issue and the moral conflicts inherent in that issue. Following each dilemma story is a series of 12 issues statements,…

The EDUTECH Report, 1995-96.

ERIC Educational Resources Information Center

EDUTECH Report, 1996

1996-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report published between April 1995 and March 1996. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue typically contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a…

The EDUTECH Report, 1996-97.

ERIC Educational Resources Information Center

EDUTECH Report, 1996

1996-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report published between April 1996 and March 1997. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue typically contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a…

Methodological Issues and Further Research in the Study of Reading Comprehension with Different Levels of Knowledge.

ERIC Educational Resources Information Center

Qian, Gaoyin

Some methodological issues in the study of levels of knowledge are reviewed, and needs for further research are explored, drawing on an analysis of 12 studies reported since the late 1970s. In the 12 studies, 16 quantitative experiments were conducted. These were assessed for internal and external validity. Analysis revealed some shortcomings in…

Technology Counts 2010: Powering Up--Mobile Learning Seeks the Spotlight in K-12 Education

ERIC Educational Resources Information Center

Education Week, 2010

2010-01-01

Much like the shifting landscape in K-12 educational technology, this year's "Technology Counts" issue is changing to address the challenges of covering schools in the digital age. The 2010 report does not issue state report cards or state policy reports. Instead, the report takes a more district- and school-level look at educational…

12 CFR 559.12 - How may a subsidiary of a savings association issue securities?

Code of Federal Regulations, 2012 CFR

2012-01-01

... acquiring a new subsidiary. If OTS notifies you within 30 days that the notice presents supervisory concerns... amount represents of the current book value of your assets on an unconsolidated basis; and the current book value of all such assets of the subsidiary; (2) The terms of any guarantee(s) issued by you or any...

12 CFR 559.12 - How may a subsidiary of a savings association issue securities?

Code of Federal Regulations, 2011 CFR

2011-01-01

... acquiring a new subsidiary. If OTS notifies you within 30 days that the notice presents supervisory concerns... amount represents of the current book value of your assets on an unconsolidated basis; and the current book value of all such assets of the subsidiary; (2) The terms of any guarantee(s) issued by you or any...

12 CFR 559.12 - How may a subsidiary of a savings association issue securities?

Code of Federal Regulations, 2013 CFR

2013-01-01

... acquiring a new subsidiary. If OTS notifies you within 30 days that the notice presents supervisory concerns... amount represents of the current book value of your assets on an unconsolidated basis; and the current book value of all such assets of the subsidiary; (2) The terms of any guarantee(s) issued by you or any...

Comparison of BMI and percentage of body fat of Indian and German children and adolescents.

PubMed

Janewa, Vanessa Schönfeld; Ghosh, Arnab; Scheffler, Christiane

2012-01-01

Today, serious health problems as overweight and obesity are not just constricted to the developed world, but also increase in the developing countries (Prentice 2006, Ramachandram et al. 2002). Focusing on this issue, BMI and percentage of body fat were compared in 2094 schoolchildren from two cross-sectional studies from India and Germany investigated in 2008 and 2009. The German children are in all age groups significantly taller, whereas the Indian children show higher values in BMI (e.g. 12 years: Indian: around 22 kg/m2; German: around 19 kg/m2) and in the percentage of body fat (e.g. 12 years: Indian: around 27%; German: around 18-20%) in most of the investigated age groups. The Indian children have significantly higher BMI between 10 and 13 (boys) respectively 14 years (girls). Indian children showed significant higher percentage of body fat between 10 and 15 years (boys) and between 8 and 16 years (girls). The difference in overweight between Indian and German children was strongest at 11 (boys) and 12 (girls) years: 70% of the Indian but 20% of the German children were classified as overweight. In countries such as India that undergo nutritional transition, a rapid increase in obesity and overweight is observed. In contrast to the industrialized countries, the risk of overweight in developing countries is associated with high socioeconomic status. Other reasons of the rapid increase of overweight in the developing countries caused by different environmental or genetic factors are discussed.

The Next Generation Airborne Polarimetric Doppler Radar

NASA Astrophysics Data System (ADS)

Vivekanandan, J.; Lee, Wen-Chau; Loew, Eric; Salazar, Jorge; Chandrasekar, V.

2013-04-01

NCAR's Electra Doppler radar (ELDORA) with a dual-beam slotted waveguide array using dual-transmitter, dual-beam, rapid scan and step-chirped waveform significantly improved the spatial scale to 300m (Hildebrand et al. 1996). However, ELDORA X-band radar's penetration into precipitation is limited by attenuation and is not designed to collect polarimetric measurements to remotely estimate microphysics. ELDORA has been placed on dormancy because its airborne platform (P3 587) was retired in January 2013. The US research community has strongly voiced the need to continue measurement capability similar to the ELDORA. A critical weather research area is quantitative precipitation estimation/forecasting (QPE/QPF). In recent years, hurricane intensity change involving eye-eyewall interactions has drawn research attention (Montgomery et al., 2006; Bell and Montgomery, 2006). In the case of convective precipitation, two issues, namely, (1) when and where convection will be initiated, and (2) determining the organization and structure of ensuing convection, are key for QPF. Therefore collocated measurements of 3-D winds and precipitation microphysics are required for achieving significant skills in QPF and QPE. Multiple radars in dual-Doppler configuration with polarization capability estimate dynamical and microphysical characteristics of clouds and precipitation are mostly available over land. However, storms over complex terrain, the ocean and in forest regions are not observable by ground-based radars (Bluestein and Wakimoto, 2003). NCAR/EOL is investigating potential configurations for the next generation airborne radar that is capable of retrieving dynamic and microphysical characteristics of clouds and precipitation. ELDORA's slotted waveguide array radar is not compatible for dual-polarization measurements. Therefore, the new design has to address both dual-polarization capability and platform requirements to replace the ELDORA system. NCAR maintains a C-130 aircraft in its fleet for airborne atmospheric measurements, including dropsonde, and in situ sampling and remote sensing of clouds, chemistry and aerosols. Therefore, the addition of a precipitation radar to the NSF/NCAR C-130 platform will produce transformational change in its mission. This new design can be cloned for C-130s operated by a number of agencies, including NOAA and the Air Force hurricane reconnaissance fleet. This paper presents a possible configuration of a novel, airborne phased array radar (APAR) to be installed on the NSF/NCAR C-130 aircraft with improved spatial resolution and polarimetric capability to meet or exceed that of ELDORA. The preliminary design, an update of the APAR project, and a future plan will be presented. References: Bell, M. M. , M. T. Montgomery, 2008: Observed Structure, Evolution, and Potential Intensity of Category 5 Hurricane Isabel (2003) from 12 to 14 September. Monthly Weather Review, Vol. 136, Issue 6, pp. 2023-2046. Hildebrand, P. H., W.-C. Lee, C. A. Walther, C. Frush, M. Randall, E. Loew, R. Neitzel, R. Parsons, J. Testud, F. Baudin, and A. LeCornec, 1996: The ELDORA/ASTRAIA airborne Doppler weather radar: High resolution observations from TOGA COARE. Bull. Amer. Metoro. Soc., 77, 213-232 Howard B. Bluestein, Roger M. Wakimoto, 2003: Mobile Radar Observations of Severe Convective Storms re Convective Storms. Meteorological Monographs, Vol. 30, Issue 52, pp. 105-105. Montgomery, M. T., M. M. Bell, S. D. Aberson, M. L. Black, 2006: Hurricane Isabel (2003): New Insights into the Physics of Intense Storms. Part I: Mean Vortex Structure and Maximum Intensity Estimates. Bull. of the American Meteorl. Soc., Vol. 87, Issue 10, pp. 1335-1347.

ELECTIONS: Issues Affecting Military and Overseas Absentee Voters

DTIC Science & Technology

2001-05-09

Office GAO For Release on Delivery Expected at 2:30 p.m., EDT Wednesday, May 9, 2001 ELECTIONS Issues Affecting Military and Overseas Absentee Voters...Type N/A Dates Covered (from... to) ("DD MON YYYY") Title and Subtitle ELECTIONS: Issues Affecting Military and Overseas Absentee Voters Contract or...Grant Number Program Element Number Authors David M. Walker Project Number Task Number Work Unit Number Performing Organization Name(s) and

Methodological Issues in Mobile Computer-Supported Collaborative Learning (mCSCL): What Methods, What to Measure and When to Measure?

ERIC Educational Resources Information Center

Song, Yanjie

2014-01-01

This study aims to investigate (1) methods utilized in mobile computer-supported collaborative learning (mCSCL) research which focuses on studying, learning and collaboration mediated by mobile devices; (2) whether these methods have examined mCSCL effectively; (3) when the methods are administered; and (4) what methodological issues exist in…

Joint Services Electronics Program

DTIC Science & Technology

1992-03-05

Packaging Considerations M. T. Raghunath (Professor Abhiram Ranade) A central issue in massively parallel computation is the design of the interconnection...programs on promising network architectures. Publications: [1] M. T. Raghunath and A. G. Ranade, A Simulation-Based Compari- son of Interconnection Networks...more difficult analog function approximation task. Network Design Issues for Fast Global Communication Professor A. Ranade with M.T. Raghunath A

7 CFR 2.29 - Chief Economist.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Energy Act of 2008 (Pub. L. 110-246). (12) Related to climate change. (i) Coordinate policy analysis, long-range planning, research, and response strategies relating to climate change issues. (ii) Provide... climate change issues. (iii) Inform the Department of scientific developments and policy issues relating...

36 CFR 72.12 - Assessment of needs, problems and issues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... used for citizen participation. (b) Physical Issues. Summary information should be provided on existing... such activities. (c) Rehabilitation Issues. Summary information should be provided on the need for... sites and properties for rehabilitation; (3) Importance of rehabilitation in specific geographic areas...

The Full-Scale Implementation of an Innovative

EPA Pesticide Factsheets

Across the United States, high levels of ammonia in drinking watersources can be found. Although ammonia in water does not posea direct health concern, ammonia nitrification can cause a numberof issues and reduce the effectiveness of some treatment processes.An innovative biological ammonia-removal drinking watertreatment process was developed and, after the success of a pilotstudy, a full-scale treatment system using the process was built ina small Iowa community. The treatment plant included a uniqueaeration contactor design that is able to consistently reduceammonia from 3.3 mg of nitrogen/L to nearly nondetectable aftera biofilm acclimation period. Close system monitoring wasperformed to avoid excess nitrite release during acclimation, andphosphate was added to enhance biological activity on the basisof pilot study findings. The treatment system is robust, reliable,and relatively simple to operate. The operations and effectivenessof the treatment plant were documented in the study.This dataset is associated with the following publication:Lytle , D., D. Williams , C. Muhlen , M. Pham , K. Kelty , M. Wildman, G. Lang, M. Wilcox, and M. Kohne. The Full-Scale Implementation of an Innovative Biological Ammonia Treatment Process. Journal AWWA. American Water Works Association, Denver, CO, USA, 107(12): E648-E665, (2015).

Simultaneous determination of levocetirizine and pseudoephedrine in dog plasma by liquid chromatography-mass spectrometry in the presence of dextrocetirizine.

PubMed

Ryu, Jae Kuk; Yoo, Sun Dong

2012-01-01

This study describes the development of a rapid and sensitive LC-ESI-MS assay for simultaneous enantioselective determination of levocetirizine and pseudoephedrine in dog plasma in the presence of dextrocetirizine. Separations were achieved on an Ultron ES-OVM chiral column using the mobile phase consisting of 10 mM aqueous NH4OAc (pH 6.6) and acetonitrile (9:1 v/v). The retention times of pseudoephedrine, dextrocetirizine, levocetirizine and diazepam (internal standard) were 5.2, 8.3, 9.6 and 11.6 min, respectively, and the total run time was less than 15 min. The assay was validated to demonstrate the linearity, accuracy and precision, recovery and stability. The calibration curves were linear over the concentration range from 1 - 200 ng/mL for levocetirizine and from 5 - 1000 ng/mL for pseudoephedrine. The developed assay was successfully applied to a pharmacokinetic study after oral administration of the racemic cetirizine (0.5 mg/kg, or 0.25 mg/kg as levocetirizine) and pseudoephedrine (12 mg/kg) in the dog. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

Bisphenol A and Bisphenol S release in milk under household conditions from baby bottles marketed in Italy.

PubMed

Russo, Giacomo; Barbato, Francesco; Cardone, Eleonora; Fattore, Margherita; Albrizio, Stefania; Grumetto, Lucia

2018-02-01

A simple and sensitive validated analytical method based on liquid chromatography coupled to tandem fluorescence (FD) and ultraviolet (UV) spectrophotometry was applied to monitor the presence of bisphenol A and bisphenol S in plastic baby bottles marketed in Italy. The limits of detection (LOD) were 3.75 ng mL -1 and 80.00 ng mL -1 , and those of quantification (LOQ) were 12.51 ng mL -1 and 260.00 ng mL -1 for BPA (FD detection) and for BPS (UV detection), respectively. BPA was found in only four samples, two samples undergone to microwave heating and two samples undergone to bottle warmer heating either at 40°C or at 80°C. Although the quantities of leached BPA were well below the reference dose for daily intake established by the European Food Safety Authority (EFSA) (4.0 µg kg -1 bw/day), the release of BPA and BPS from these plastic materials should be carefully considered by the government authorities to increase people's awareness on this issue and to protect the most vulnerable population group.

12 CFR 1.130 - Type II securities; guidelines for obligations issued for university and housing purposes.

Code of Federal Regulations, 2014 CFR

2014-01-01

...; guidelines for obligations issued for university and housing purposes. (a) Investment quality. An obligation issued for housing, university, or dormitory purposes is a Type II security only if it: (1) Qualifies as... issued for university and housing purposes. 1.130 Section 1.130 Banks and Banking COMPTROLLER OF THE...

12 CFR 1.130 - Type II securities; guidelines for obligations issued for university and housing purposes.

Code of Federal Regulations, 2011 CFR

2011-01-01

...; guidelines for obligations issued for university and housing purposes. (a) Investment quality. An obligation issued for housing, university, or dormitory purposes is a Type II security only if it: (1) Qualifies as... issued for university and housing purposes. 1.130 Section 1.130 Banks and Banking COMPTROLLER OF THE...

12 CFR 1.130 - Type II securities; guidelines for obligations issued for university and housing purposes.

Code of Federal Regulations, 2012 CFR

2012-01-01

...; guidelines for obligations issued for university and housing purposes. (a) Investment quality. An obligation issued for housing, university, or dormitory purposes is a Type II security only if it: (1) Qualifies as... issued for university and housing purposes. 1.130 Section 1.130 Banks and Banking COMPTROLLER OF THE...

12 CFR 1.130 - Type II securities; guidelines for obligations issued for university and housing purposes.

Code of Federal Regulations, 2013 CFR

2013-01-01

...; guidelines for obligations issued for university and housing purposes. (a) Investment quality. An obligation issued for housing, university, or dormitory purposes is a Type II security only if it: (1) Qualifies as... issued for university and housing purposes. 1.130 Section 1.130 Banks and Banking COMPTROLLER OF THE...

An Estimation Theory Approach to Detection and Ranging of Obscured Targets in 3-D LADAR Data

DTIC Science & Technology

2006-03-01

Bmat = [sum(Bsim*(1-(x-m1).^2/w^2).*rect_f(M1,:))-sum(simdat.*(1-(x- m1).^2/w^2).*rect_f(M1,:)); sum(Bsim*(1-(x-m2...2/w^2).*rect_f(M2,:))-sum(simdat.*(1-(x- m2).^2/w^2).*rect_f(M2,:))]; Xmat(2*M1-1:2*M1,M2) = inv(Amat)* Bmat ; %I=I+1; Est...1-(x-m2).^2/w^2).^2.*rect_f(M2,:))]; Bmat = [sum(Bsim.*(1-(x-m1).^2/w^2).*rect_f(M1,:))-sum(simdat’.*(1-(x- m1).^2/w^2).*rect_f

Security Aspects of Smart Cards vs. Embedded Security in Machine-to-Machine (M2M) Advanced Mobile Network Applications

NASA Astrophysics Data System (ADS)

Meyerstein, Mike; Cha, Inhyok; Shah, Yogendra

The Third Generation Partnership Project (3GPP) standardisation group currently discusses advanced applications of mobile networks such as Machine-to-Machine (M2M) communication. Several security issues arise in these contexts which warrant a fresh look at mobile networks’ security foundations, resting on smart cards. This paper contributes a security/efficiency analysis to this discussion and highlights the role of trusted platform technology to approach these issues.

Legal Issues. Unit 12. Level 1. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 301-12.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on legal issues in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 1 of learning--understanding the…

17 CFR 210.12-14 - Investments in and advances to affiliates.

Code of Federal Regulations, 2010 CFR

2010-04-01

... § 210.12-14 Investments in and advances to affiliates. [For management investment companies only] Col. A Col. B Col. C Col. D Col. E Name of issuer and title of issue or nature of indebtedness 1 Number of... close of period 2,3,4,5 (1) Credited to income (2) Other 1 (a) List each issue separately and group (1...

Legal Issues. Unit 12. Level 3. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 303-12.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on legal issues in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 3 of learning--starting and…

Earth Day 1990: Lesson Plan and Home Survey--7-12. Energy, Solid Waste/Recycling, Toxics, Transportation, and Water with Fact Sheets and Action Guide.

ERIC Educational Resources Information Center

Holm-Shuett, Amy; Shuett, Greg

The purpose of this 7-12 curriculum is to provide teachers and other educators with classroom lessons and home surveys that are a starting point for understanding five significant environmental issues - water, toxics, energy, transportation, and solid waste/recycling. While each of these environmental issues is complex and has far-reaching…

Improving Butanol Fermentation To Enter the Advanced Biofuel Market

PubMed Central

Tracy, Bryan P.

2012-01-01

ABSTRACT 1-Butanol is a large-volume, intermediate chemical with favorable physical and chemical properties for blending with or directly substituting for gasoline. The per-volume value of butanol, as a chemical, is sufficient for investing into the recommercialization of the classical acetone-butanol-ethanol (ABE) (E. M. Green, Curr. Opin. Biotechnol. 22:337–343, 2011) fermentation process. Furthermore, with modest improvements in three areas of the ABE process, operating costs can be sufficiently decreased to make butanol an economically viable advanced biofuel. The three areas of greatest interest are (i) maximizing yields of butanol on any particular substrate, (ii) expanding substrate utilization capabilities of the host microorganism, and (iii) reducing the energy consumption of the overall production process, in particular the separation and purification operations. In their study in the September/October 2012 issue of mBio, Jang et al. [mBio 3(5):e00314-12, 2012] describe a comprehensive study on driving glucose metabolism in Clostridium acetobutylicum to the production of butanol. Moreover, they execute a metabolic engineering strategy to achieve the highest yet reported yields of butanol on glucose. PMID:23232720

Warming trend in the western Mediterranean deep water

NASA Astrophysics Data System (ADS)

Bethoux, J. P.; Gentili, B.; Raunet, J.; Tailliez, D.

1990-10-01

THE western Mediterranean Sea comprises three water masses: a surface layer (from 0 to ~150 m depth), an intermediate layer (~150-400 m) issuing from the eastern basin, and a deep water mass at depths below 400 m. The deep water is homogeneous and has maintained a more or less constant temperature and salinity from the start of the century until recently1. Here we report measurements from the Medatlante cruises of December 1988 and August 1989, which show the deep layer to be 0.12 °C warmer and ~0.03 p.s.u. more saline than in 1959. Taking these data together with those from earlier cruises, we find a trend of continuously increasing temperatures over the past three decades. These deep-water records reflect the averaged evolution of climate conditions at the surface during the winter, when the deep water is formed. Consideration of the heat budget and water flux in the Mediterranean2,3 leads to the possibility that the deep-water temperature trend may be the result of greenhouse-gas-induced local warming.

12 CFR 12.1 - Authority, purpose, and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Authority, purpose, and scope. 12.1 Section 12... CONFIRMATION REQUIREMENTS FOR SECURITIES TRANSACTIONS § 12.1 Authority, purpose, and scope. (a) Authority. This part is issued pursuant to 12 U.S.C. 24, 92a, and 93a. (b) Purpose. This part establishes rules...

Finite-size effects for anisotropic 2D Ising model with various boundary conditions

NASA Astrophysics Data System (ADS)

Izmailian, N. Sh

2012-12-01

We analyze the exact partition function of the anisotropic Ising model on finite M × N rectangular lattices under four different boundary conditions (periodic-periodic (pp), periodic-antiperiodic (pa), antiperiodic-periodic (ap) and antiperiodic-antiperiodic (aa)) obtained by Kaufman (1949 Phys. Rev. 76 1232), Wu and Hu (2002 J. Phys. A: Math. Gen. 35 5189) and Kastening (2002 Phys. Rev. E 66 057103)). We express the partition functions in terms of the partition functions Zα, β(J, k) with (α, β) = (0, 0), (1/2, 0), (0, 1/2) and (1/2, 1/2), J is an interaction coupling and k is an anisotropy parameter. Based on such expressions, we then extend the algorithm of Ivashkevich et al (2002 J. Phys. A: Math. Gen. 35 5543) to derive the exact asymptotic expansion of the logarithm of the partition function for all boundary conditions mentioned above. Our result is f = fbulk + ∑∞p = 0fp(ρ, k)S-p - 1, where f is the free energy of the system, fbulk is the free energy of the bulk, S = MN is the area of the lattice and ρ = M/N is the aspect ratio. All coefficients in this expansion are expressed through analytical functions. We have introduced the effective aspect ratio ρeff = ρ/sinh 2Jc and show that for pp and aa boundary conditions all finite size correction terms are invariant under the transformation ρeff → 1/ρeff. This article is part of ‘Lattice models and integrability’, a special issue of Journal of Physics A: Mathematical and Theoretical in honour of F Y Wu's 80th birthday.

Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2.

PubMed

Hovey, Liam; Fowler, C Andrew; Mahling, Ryan; Lin, Zesen; Miller, Mark Stephen; Marx, Dagan C; Yoder, Jesse B; Kim, Elaine H; Tefft, Kristin M; Waite, Brett C; Feldkamp, Michael D; Yu, Liping; Shea, Madeline A

2017-05-01

Several members of the voltage-gated sodium channel family are regulated by calmodulin (CaM) and ionic calcium. The neuronal voltage-gated sodium channel Na V 1.2 contains binding sites for both apo (calcium-depleted) and calcium-saturated CaM. We have determined equilibrium dissociation constants for rat Na V 1.2 IQ motif [IQRAYRRYLLK] binding to apo CaM (~3nM) and (Ca 2+ ) 4 -CaM (~85nM), showing that apo CaM binding is favored by 30-fold. For both apo and (Ca 2+ ) 4 -CaM, NMR demonstrated that Na V 1.2 IQ motif peptide (Na V 1.2 IQp ) exclusively made contacts with C-domain residues of CaM (CaM C ). To understand how calcium triggers conformational change at the CaM-IQ interface, we determined a solution structure (2M5E.pdb) of (Ca 2+ ) 2 -CaM C bound to Na V 1.2 IQp . The polarity of (Ca 2+ ) 2 -CaM C relative to the IQ motif was opposite to that seen in apo CaM C -Na v 1.2 IQp (2KXW), revealing that CaM C recognizes nested, anti-parallel sites in Na v 1.2 IQp . Reversal of CaM may require transient release from the IQ motif during calcium binding, and facilitate a re-orientation of CaM N allowing interactions with non-IQ Na V 1.2 residues or auxiliary regulatory proteins interacting in the vicinity of the IQ motif. Copyright © 2017 Elsevier B.V. All rights reserved.

A Systematic Review of the mHealth Interventions to Prevent Alcohol and Substance Abuse

PubMed Central

KAZEMI, DONNA M.; BORSARI, BRIAN; LEVINE, MAUREEN J.; LI, SHAOYU; LAMBERSON, KATIE A.; MATTA, LAURA A.

2017-01-01

Substance abuse in young adults is a public health issue with costs to the individual and society. There is mounting evidence that the increased uses of mHealth approaches have promise as a way to facilitate reductions in substance use. This systematic review evaluated the recent body of research on mHealth-based interventions for substance use, with aims of (a) examining the functionality and effectiveness of these interventions, (b) evaluating the available research on the effectiveness of these interventions for substance use, and (c) evaluating the design, methodology, results, theoretical grounding, limitations, and implications of each study. We identified eligible studies by searching electronic databases using Boolean methods. The reviewed studies (N = 12) indicated that that a wide range of Internet-based, text messaging, and smartphone application interventions have been developed to address substance use. Interventions had an assortment of features; participants in each study highlighted the ease and convenience of the interventions; and the majority of studies provided support for the efficacy of mHealth in reducing substance use. Mobile technology is a promising tool for reducing substance use and warrants further development. Future practice including the use of mHealth interventions can be an integral part of reducing substance use. PMID:28394729

Liquid metals as a divertor plasma-facing material explored using the Pilot-PSI and Magnum-PSI linear devices

NASA Astrophysics Data System (ADS)

Morgan, T. W.; Rindt, P.; van Eden, G. G.; Kvon, V.; Jaworksi, M. A.; Lopes Cardozo, N. J.

2018-01-01

For DEMO and beyond, liquid metal plasma-facing components are considered due to their resilience to erosion through flowed replacement, potential for cooling beyond conduction and inherent immunity to many of the issues of neutron loading compared to solid materials. The development curve of liquid metals is behind that of e.g. tungsten however, and tokamak-based research is currently somewhat limited in scope. Therefore, investigation into linear plasma devices can provide faster progress under controlled and well-diagnosed conditions in assessing many of the issues surrounding the use of liquid metals. The linear plasma devices Magnum-PSI and Pilot-PSI are capable of producing DEMO-relevant plasma fluxes, which well replicate expected divertor conditions, and the exploration of physics issues for tin (Sn) and lithium (Li) such as vapour shielding, erosion under high particle flux loading and overall power handling are reviewed here. A deeper understanding of erosion and deposition through this work indicates that stannane formation may play an important role in enhancing Sn erosion, while on the other hand the strong hydrogen isotope affinity reduces the evaporation rate and sputtering yields for Li. In combination with the strong redeposition rates, which have been observed under this type of high-density plasma, this implies that an increase in the operational temperature range, implying a power handling range of 20-25 MW m-2 for Sn and up to 12.5 MW m-2 for Li could be achieved. Vapour shielding may be expected to act as a self-protection mechanism in reducing the heat load to the substrate for off-normal events in the case of Sn, but may potentially be a continual mode of operation for Li.

Design and implementation of a software package to control a network of robotic observatories

NASA Astrophysics Data System (ADS)

Tuparev, G.; Nicolova, I.; Zlatanov, B.; Mihova, D.; Popova, I.; Hessman, F. V.

2006-09-01

We present a description of a reusable software package able to control a large, heterogeneous network of fully and semi-robotic observatories initially developed to run the MONET network of two 1.2 m telescopes. Special attention is given to the design of a robust, long-term observation scheduler which also allows the trading of observation time and facilities within various networks. The handling of the ``Phase I&II" project-development process, the time-accounting between complex organizational structures, and usability issues for making the package accessible not only to professional astronomers, but also to amateurs and high-school students is discussed. A simple RTML-based solution to link multiple networks is demonstrated.

Measurement of the 1s Hyperfine Transition of Two Tl^80+ Isotopes

NASA Astrophysics Data System (ADS)

Beiersdorfer, P.; Utter, S. B.; Wong, K. L.; Crespo López-Urrutia, J. R.; Britten, J. A.; Chen, H.; Thoe, R. S.; Thorn, D. B.; Träbert, E.; Gustavsson, M. G. H.; Forssén, C.; Mårtenson-Pendrill, A.-M.; Harris, C. L.

2001-05-01

The hyperfine splitting of the 1s ground state has been measured for the two stable isotopes of hydrogen-like Tl using emission spectroscopy in the SuperEBIT electron beam ion trap. The results are 3858.22± 0.30 Åfor ^203Tl^80+ and 3821.84± 0.34 Åfor ^205Tl^80+. These differ by about 60 Å from recent and about 19 Å from very recent calculations, illustrating unsolved issues affecting these transitions in hydrogen-like ions. The wavelength difference Δλ = 36.38± 0.35 Å is consistent with estimates based on hyperfine anomaly data for neutral Tl. By using previously determined nuclear magnetic moments and applying appropriate corrections for the nuclear charge distribution and radiative effects, the experimental splittings can be interpreted in terms of nuclear magnetization radii < r^2_m>^1/2= 5.83(14) fm for ^203Tl and < r^2_m>^1/2= 5.89(14) fm for ^205Tl. These values are 10% larger than derived from single-particle nuclear magnetization models, and are slightly larger than the corresponding charge distributions. *Work performed under the auspices of DOE by UCLLNL under contract W-7405-ENG-48 and supported by the Office of Basic Energy Sciences.

Treatment of psoriasis with interleukin-12/23 monoclonal antibody: a systematic review.

PubMed

Wu, Yan; Chen, Jing; Li, Yuan-Hong; Ma, Guo-Zhang; Chen, John Z S; Gao, Xing-Hua; Chen, Hong-Duo

2012-01-01

To systematically review the efficacy and safety of interleukin-12/23 monoclonal antibody (IL-12/23 mAb) on psoriasis. Relevant randomized controlled trials (RCTs) were identified by systematic literature searches in MEDLINE, OVID, EMBASE, Cochrane Library, and the metaRegister of Controlled Trials. The efficacy outcomes and adverse effects of included RCTs were critically assessed. A total of 3365 participants in 5 multicenter RCTs were included. The RRs of most efficacy outcomes showed significant differences between i) IL-12/23 mAb and placebo at week 12/16; ii) IL-12/23 mAb and etanercept at week 12; iii) IL-12/23 mAb in high dose and IL-12/23 mAb in low dose at week 24/28. Increasing treatment times did not obviously provide additional benefit to efficacy improvement. The adverse events of IL-12/23 mAb were similar to those of controls. Antibodies to IL-12/23 mAb were mostly undetected or shown at low titer. Treatment with IL-12/23 mAb did not influence related biochemical markers. IL-12/23 mAb was effective in the treatment of psoriasis on skin lesions, health-related quality of life and psoriatic arthritis in the short-term. The increase in treatment time points was not associated with additional efficacy and dose-dependence was observed with the ongoing treatment up to week 24/28. The adverse effects were minimal and tolerable.

Backbone resonance assignments of complexes of human voltage-dependent sodium channel NaV1.2 IQ motif peptide bound to apo calmodulin and to the C-domain fragment of apo calmodulin.

PubMed

Mahling, Ryan; Kilpatrick, Adina M; Shea, Madeline A

2017-10-01

Human voltage-gated sodium channel Na V 1.2 has a single pore-forming α-subunit and two transmembrane β-subunits. Expressed primarily in the brain, Na V 1.2 is critical for initiation and propagation of action potentials. Milliseconds after the pore opens, sodium influx is terminated by inactivation processes mediated by regulatory proteins including calmodulin (CaM). Both calcium-free (apo) CaM and calcium-saturated CaM bind tightly to an IQ motif in the C-terminal tail of the α-subunit. Our thermodynamic studies and solution structure (2KXW) of a C-domain fragment of apo 13 C, 15 N- CaM (CaM C ) bound to an unlabeled peptide with the sequence of rat Na V 1.2 IQ motif showed that apo CaM C (a) was necessary and sufficient for binding, and (b) bound more favorably than calcium-saturated CaM C . However, we could not monitor the Na V 1.2 residues directly, and no structure of full-length CaM (including the N-domain of CaM (CaM N )) was determined. To distinguish contributions of CaM N and CaM C , we used solution NMR spectroscopy to assign the backbone resonances of a complex containing a 13 C, 15 N-labeled peptide with the sequence of human Na V 1.2 IQ motif (Na V 1.2 IQp ) bound to apo 13 C, 15 N-CaM or apo 13 C, 15 N-CaM C . Comparing the assignments of apo CaM in complex with Na V 1.2 IQp to those of free apo CaM showed that residues within CaM C were significantly perturbed, while residues within CaM N were essentially unchanged. The chemical shifts of residues in Na V 1.2 IQp and in the C-domain of CaM were nearly identical regardless of whether CaM N was covalently linked to CaM C . This suggests that CaM N does not influence apo CaM binding to Na V 1.2 IQp .

77 FR 70157 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

...-5149. Comments Due: 5 p.m. ET 12/5/12. The filings are accessible in the Commission's eLibrary system... Number: 20121113-5413. Comments Due: 5 p.m. ET 12/4/12. Docket Numbers: ER12-2591-002. Applicants.... Accession Number: 20121114-5142. Comments Due: 5 p.m. ET 12/5/12. Docket Numbers: ER11-2932-002. Applicants...

MRAPs, Irregular Warfare, and Pentagon Reform

DTIC Science & Technology

2009-01-01

76 JFQ / issue 55, 4 th quarter 2009 ndupress .ndu.edu MRAPs, Irregular Warfare, and Pentagon Reform By C h r i s t o p h e r J . l a m b , m...a t t h e w J . s C h m i D t , and b e r i t g . F i t z s i m m o n s Mine resistant ambush protected (MRAP) vehicles offer an excellent...issue 55, 4 th quarter 2009 / JFQ 77 LAMB, SCHMIDT, and FITZSIMMONS By C h r i s t o p h e r J . l a m b , m a t t h e w J . s C h m i D t

Improved structure and long-life blanket concepts for heliotron reactors

NASA Astrophysics Data System (ADS)

Sagara, A.; Imagawa, S.; Mitarai, O.; Dolan, T.; Tanaka, T.; Kubota, Y.; Yamazaki, K.; Watanabe, K. Y.; Mizuguchi, N.; Muroga, T.; Noda, N.; Kaneko, O.; Yamada, H.; Ohyabu, N.; Uda, T.; Komori, A.; Sudo, S.; Motojima, O.

2005-04-01

New design approaches are proposed for the LHD-type heliotron D-T demo-reactor FFHR2 to solve the key engineering issues of blanket space limitation and replacement difficulty. A major radius of over 14 m is selected to permit a blanket-shield thickness of about 1 m and to reduce the neutron wall loading and toroidal field, while achieving an acceptable cost of electricity. Two sets of optimization are successfully carried out. One is to reduce the magnetic hoop force on the helical coil support structures by adjustment of the helical winding coil pitch parameter and the poloidal coils design, which facilitates expansion of the maintenance ports. The other is a long-life blanket concept using carbon armour tiles that soften the neutron energy spectrum incident on the self-cooled flibe-reduced activation ferritic steel blanket. In this adaptation of the spectral-shifter and tritium breeder blanket (STB) concept a local tritium breeding ratio over 1.2 is feasible by optimized arrangement of the neutron multiplier Be in the carbon tiles, and the radiation shielding of the superconducting magnet coils is also significantly improved. Using constant cross sections of a helically winding shape, the 'screw coaster' concept is proposed to replace in-vessel components such as the STB armour tiles. The key R&D issues for developing the STB concept, such as radiation effects on carbon and enhanced heat transfer of Flibe, are elucidated.

A case study of risk assessment in contaminated site remediation in China

NASA Astrophysics Data System (ADS)

Ye, S.; Guo, J.; Wu, J.; Wang, J.; Chien, C.; Stahl, R.; Mack, E.; Grosso, N.

2013-12-01

A field site in Nanjing, China was selected for a case study of risk assessment in contaminated site remediation. This site is about 100m long and 100m wide. A chemical plant (1999-2010) at the site manufactured optical brightener PF, 2-Amino-4-methylphenol and 2-Nitro-4-methylphenol, totally three products. Soil and groundwater samples were collected and analyzed for PPL 126 (126 pollutants in the 'Priority Pollutants List' issued by US EPA). Values of the Dutch Standards were used as the screening criteria for soil and ground water. Low levels of ethylbenezene, chlorobenzene, 1,3-dichlorobenzene and 1,4- dichlorobenzene were detected in one soil sample. Concentrations above Dutch Target Value (DTV) of benzene, toluene, ethylbenzene, chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, and/or 1,2,4-trichlorobenzene, phenol, and/or 2,4-dichlorophenol were exhibited in two groundwater samples. The ground water was especially highly impacted by bichlorobenzenes and trichlorobenzenes. The maximum concentration of impacts was 7.3 mg/L of 1,2,4-trichlorobenzene in groundwater which was 730 times higher than Dutch Intervention Values (DIV). Risk of soil and groundwater at this site was assessed according to the guidelines issued by Chinese MEP and US EPA, respectively. Finally, remedy techniques were selected according to the result of risk assessment and the characteristics of hydrogeology conditions and contaminants.

Warkworth 12-m VLBI Station: WARK12M

NASA Technical Reports Server (NTRS)

Weston, Stuart; Takiguchi, Hiroshi; Natusch, Tim; Woodburn, Lewis; Gulyaev, Sergei

2013-01-01

The Warkworth 12-m radio telescope is operated by the Institute for Radio Astronomy and Space Research (IRASR) at AUT University, Auckland, New Zealand. Here we review the characteristics of the 12-m VLBI station and report on a number of activities and technical developments in 2012.

Great Issues: Social Studies Elective - Grade 12; Great Issues A - Regents Credit; Great Issues B - School Credit.

ERIC Educational Resources Information Center

Syracuse City School District, NY.

This revised social studies course outline follows the New York State Methodology in the development of understandings, the building of concepts, and the generalizations arrived at in the study of a variety of broad issues at the local, state, national, and international levels. General objectives are to provide students with opportunity for…

Parent News: A Compilation of 1997 Issues.

ERIC Educational Resources Information Center

Robertson, Anne S., Ed.

1997-01-01

This document consists of the 12 issues of "Parent News" (an electronic Internet magazine for parents, prepared for the National Parent Information Network) published during 1997. Each monthly issue contains feature articles describing the activities of the National Parent Information Network, summarizing research useful to parents,…

Stress in Children Bibliography.

ERIC Educational Resources Information Center

Gerlach, Kent

This annotated bibliography concerns itself with issues that may contribute to childhood stress, provides resource materials for teachers and parents, and covers a wide variety of fiction and non-fiction for students (K-12). The publication's organization along with examples of the issues included follows: (1) adolescence issues (substance abuse,…

An all-electron density functional theory study of the structure and properties of the neutral and singly charged M12 and M13 clusters: M = Sc-Zn.

PubMed

Gutsev, G L; Weatherford, C W; Belay, K G; Ramachandran, B R; Jena, P

2013-04-28

The electronic and geometrical structures of the M12 and M13 clusters where M = Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, and Zn along with their singly negatively and positively charged ions are studied using all-electron density functional theory within the generalized gradient approximation. The geometries corresponding to the lowest total energy states of singly and negatively charged ions of V13, Mn12, Co12, Ni13, Cu13, Zn12, and Zn13 are found to be different from the geometries of the corresponding neutral parents. The computed ionization energies of the neutrals, vertical electron detachment energies from the anions, and energies required to remove a single atom from the M13 and M13(+) clusters are in good agreement with experiment. The change in a total spin magnetic moment of the cation or anion with respect to a total spin magnetic moment of the corresponding neutral is consistent with the one-electron model in most cases, i.e., they differ by ±1.0 μ(B). Exceptions are found only for Sc12(-), Ti12(+), Mn12(-), Mn12(+), Fe12(-), Fe13(+), and Co12(+).

77 FR 60976 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

.... Comments Due: 5 p.m. ET 10/10/12. Docket Numbers: RP12-1103-000. Applicants: Dominion Transmission, Inc...: 20120927-5025. Comments Due: 5 p.m. ET 10/9/12. Docket Numbers: RP12-1072-000. Applicants: Golden Triangle... effective 12/1/2012. Filed Date: 9/27/12. Accession Number: 20120927-5032. Comments Due: 5 p.m. ET 10/9/12...

77 FR 14358 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

...: 3/1/12. Accession Number: 20120301-5204. Comments Due: 5 p.m. ET 3/13/12. Docket Numbers: RP12-467.... Accession Number: 20120301-5078. Comments Due: 5 p.m. ET 3/13/12. Docket Numbers: RP12-451-000. Applicants.../1/2012. Filed Date: 3/1/12. Accession Number: 20120301-5079. Comments Due: 5 p.m. ET 3/13/12. Docket...

77 FR 20810 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

.... Accession Number: 20120330-5140. Comments Due: 5 p.m. ET 4/11/12. Docket Numbers: RP12-562-000. Applicants...: 3/30/12. Accession Number: 20120330-5158. Comments Due: 5 p.m. ET 4/11/12. Docket Numbers: RP12-564.... Comments Due: 5 p.m. ET 4/11/12. Docket Numbers: RP12-565-000. Applicants: Gulf South Pipeline Company, LP...

"Before We Teach It, We Have to Learn It": Wisconsin Act 31 Compliance within Public Teacher Preparation Programs

ERIC Educational Resources Information Center

Moody, Heather Ann

2013-01-01

Wisconsin Act 31 was established for the purpose of addressing American Indian history, culture, and sovereignty within K-12 schools as a response to treaty rights issues in the late 1970s and early 1980s. Yet, in the 21 st century there remain issues with compliance throughout not only K-12 schools but also institutions of higher education. The…

Legal Issues. Unit 12. Level 2. Instructor Guide. PACE: Program for Acquiring Competence in Entrepreneurship. Third Edition. Research & Development Series No. 302-12.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center on Education and Training for Employment.

This instructor guide for a unit on legal issues in the PACE (Program for Acquiring Competence in Entrepreneurship) curriculum includes the full text of the student module and lesson plans, instructional suggestions, and other teacher resources. The competencies that are incorporated into this module are at Level 2 of learning--planning for a…

Theory of mind and prosocial behavior in childhood: A meta-analytic review.

PubMed

Imuta, Kana; Henry, Julie D; Slaughter, Virginia; Selcuk, Bilge; Ruffman, Ted

2016-08-01

It has been argued that children who possess an advanced theory of mind (ToM) are more likely to act prosocially, yet the empirical findings are mixed. To address this issue definitively, a meta-analytic integration of all prior literature that met appropriate inclusion criteria was conducted. In total, 76 studies including 6,432 children between 2 and 12 years of age contributed to these analyses. Collapsed across all studies, a significant association emerged (r = .19), indicating that children with higher ToM scores also received higher scores on concurrent measures of prosocial behavior. The magnitude of this effect was similar across ToM assessments requiring identification of others' cognitions versus emotions, and it existed irrespective of whether the ToM measure imposed demands on false belief reasoning or not. The association with ToM was also evident for different subtypes of prosocial behavior (helping, cooperating, comforting). ToM had a similar effect for boys and girls, but was slightly stronger in children aged 6 years or older, relative to their younger peers. Taken together, these findings provide the strongest evidence to date that being able to explicitly consider what other people are thinking and feeling is related to children's tendencies to act prosocially, although the magnitude of the association is relatively weak. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Changes in pulmonary function and functional capacity in adolescents with mild idiopathic scoliosis: observational cohort study

PubMed Central

Abdelaal, Ashraf Abdelaal Mohamed; Abd El Kafy, Ehab Mohamed Abo El Soad; Elayat, Mohamed Salah Eldien Mohamed; Sabbahi, Mohamed; Badghish, Mohamed Salem Saed

2017-01-01

Objective This observational cohort study aimed to evaluate ventilatory function (VF) and functional exercise capacity (FEC) in mild adolescent idiopathic scoliosis (AIS). Methods Seventy-three adolescents with idiopathic scoliosis, aged approximately 10 to 17 years (mean age: 13.43 ± 1.27 years), with a Cobb angle less than 20° (mean: 16.44° ± 1.59°), met the inclusion criteria and were assigned to group A. Another 34 healthy adolescents with normal VF and FEC served as controls (group B). Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), maximum voluntary ventilation (MVV), and FEC (by the 6-minute walk test [6MWT]) were the main outcome measures. Results Post-study mean values of FVC, FEV1, FEV1/FVC, MVV, and the 6MWT were 2.42 ± 0.36 L and 3.26 ± 0.59 L, 2.14 ± 0.31 L and 3.03 ± 0.43 L, 88.13% ± 3.89% and 91.14% ± 4.67%, 76.96 ± 6.85 L/m and 107.61 ± 11.44 L/m, and 581.12 ± 12.25 m and 627.74 ± 15.27 m in groups A and B, respectively. Between-group comparisons showed significant differences in FVC, FEV1, FEV1/FVC, MVV, and the 6MWT. Conclusion Mild pulmonary and functional restrictions start early in mild AIS. This issue requires immediate intervention to prevent further deterioration. PMID:28661261

[Cleaning and disinfection of surfaces in hospitals: Data on structure, process and result in the Frankfurt/Main Metropolitan Area].

PubMed

Hausemann, A; Hofmann, H; Otto, U; Heudorf, Ursel

2015-06-01

In addition to hand hygiene and reprocessing of medical products, cleaning and disinfection of surfaces is also an important issue in the prevention of germ transmission and by implication infections. Therefore, in 2014, the quality of the structure, process and result of surface preparation of all hospitals in Frankfurt am Main, Germany, was monitored. All 17 hospitals transferred information on the quality of structure. Process quality was obtained through direct observation during cleaning and disinfection of rooms and their plumbing units. Result quality was gained using the fluorescent method, i.e. marking surfaces with a fluorescent liquid and testing if this mark has been sufficiently removed by cleaning. Structure quality: in all hospitals the employees were trained regularly. In 12 of them, the foremen had the required qualifications, in 6 hospitals unclarity as to the intersection of the cleaning and care services remained. In 14 hospitals only visible contamination was cleaned on the weekends, whereas complete cleaning was reported to take place in 12 hospitals on Saturdays and in 2 hospitals on Sundays. The contractually stipulated cleaning (observations specified in brackets) averaged 178 m(2)/h (148 m(2)/h) per patient room and 69 m(2)/h (33 m(2)/h) for bathrooms. Process quality: during process monitoring, various hand contact surfaces were prepared insufficiently. Result quality: 63 % of fluorescent markings were appropriately removed. The need for improvement is given especially in the area of the qualification of the foremen and a in a clear definition of the intersection between cleaning and care services, as well as in the regulations for weekends and public holidays.

Suicidal risk among patients enrolled in methadone maintenance treatment: HCV status and implications for suicide prevention (ANRS Methaville).

PubMed

Michel, Laurent; Lions, Caroline; Maradan, Gwenaelle; Mora, Marion; Marcellin, Fabienne; Morel, Alain; Spire, Bruno; Roux, Perrine; Carrieri, Patrizia M

2015-10-01

Suicide is a critical issue among opioid users. The aim of this study was to assess the relationship between HCV status and suicidal risk in patients receiving methadone treatment. We used data from Methaville, a multicenter, pragmatic randomized trial designed to evaluate the feasibility of methadone induction in primary care compared with induction in specialized centers. Suicidal risk was assessed at enrollment and after one year of methadone treatment using the suicidality module in the MINI International Neuropsychiatric Interview. Socio-demographic characteristics, drug and alcohol consumption, behavioral and personality factors, history of drug use and health indicators were also assessed. A total of 195 individuals were enrolled from January 2009 to December 2010. Suicidal risk assessment was available at month 0 (M0) and M12 for 159 (72%) and 118 (73%) individuals, respectively. Forty-four (28%) were at risk of suicide at M0 and 17 (14%) at M12 (p=0.004). One patient attempted suicide by overdose during the one-year follow-up. The following three factors were associated with suicidal risk: hepatitis C virus (HCV) positive status (OR [95%CI]=17.25 [1.14-161.07]; p=0.04), receiving food assistance (OR [95%CI]=0.05 [0.00-1.05]; p=0.05) and a higher number of health problems (OR [95%CI]=1.24 [1.08-1.44]; p=0.003). Special attention should be given to HCV-positive patients through suicidal risk prevention strategies and routine suicide assessment as part of a comprehensive approach to prevention and care for opioid users. Our results represent a new and powerful argument for the expansion of access to HCV treatment to drug users with chronic infection. Copyright © 2015 Elsevier Inc. All rights reserved.

State Issues Report, 1998-99.

ERIC Educational Resources Information Center

Education Commission of the States, Denver, CO.

This document contains raw data on the various issues affecting the pre-K-12 community. The information was collected from Lexis-Nexis, legislative staff, state newsletters, school board/teacher associations, and various media. The issues presented here are in alphabetical order and are divided under three headings: state name, status of the…

Workforce Education: Issues for the New Century.

ERIC Educational Resources Information Center

Pautler, Albert J., Jr.

This paper is intended to guide small groups of vocational educators in discussions regarding work force education issues for the next century. The following work force issues are suggested: the aging work force; vocational education's role in reforming K-12 education; distance education for technical education programs; the labor shortages…

Literature for Children: Avoiding Controversy and Intellectual Challenge.

ERIC Educational Resources Information Center

Adams, Dennis M.

1986-01-01

Discusses lack of literature on controversial subjects that can help prepare children and young adults to deal perceptively with complexities of modern world. Highlights include meeting the issues head-on, glorifying armed conflict in video media, avoiding issues of nuclear war, and intellectual depth and dealing with controversial issues. (12…

Mid-Western Educational Researcher, 1999.

ERIC Educational Resources Information Center

Bainer, Deborah L., Ed.; Kramer, Gene A., Ed.; Smith, Richard M., Ed.

1999-01-01

Volume 12 of the Mid-Western Educational Researcher contains four issues. The first issue includes kick-off, keynote, luncheon, and presidential addresses from the annual meeting of the Mid-Western Educational Research Association (MWERA), held in Chicago, Illinois, in October 1998. Issue 3 is the program for MWERA's annual meeting in Chicago,…

Rural Communities and Rural Social Issues: Priorities for Research.

ERIC Educational Resources Information Center

Black, Alan; Duff, John; Saggers, Sherry; Baines, Patricia

This report recommends priorities for research into rural communities and rural social issues in Australia, based on an extensive literature review, surveys of policymaking agencies and researchers, and discussion at a national workshop in May 1999. Chapters 1-2 outline the study's background, purpose, and methodology; discuss issues in the…

Two-color detector: Mercury-cadmium-telluride as a terahertz and infrared detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sizov, F.; Zabudsky, V.; Petryakov, V.

2015-02-23

In this paper, issues associated with the development of infrared (IR) and terahertz (THz) radiation detectors based on HgCdTe are discussed. Two-color un-cooled and cooled to 78 K narrow-gap mercury-cadmium-telluride semiconductor thin layers with antennas were considered both as sub-THz (sub-THz) direct detection bolometers and 3–10 μm IR photoconductors. The noise equivalent power (NEP) for one of the detectors studied at ν ≈ 140 GHz reaches NEP{sub 300 K} ≈ 4.5 × 10{sup −10} W/Hz{sup 1/2} and NEP{sub 78 K} ≈ 5 × 10{sup −9} W/Hz{sup 1/2}. The same detector used as an IR photoconductor showed the responsivity at temperatures T = 78 K and 300 K with signal-to-noisemore » ratio S/N ≈ 750 and 50, respectively, under illumination by using IR monochromator and globar as a thermal source.« less

Photonic Magnetic Field Sensor

NASA Astrophysics Data System (ADS)

Wyntjes, Geert

2002-02-01

Small, in-line polarization rotators or isolators to reduce feedback in fiber optic links can be the basis for excellent magnetic field sensors. Based on the giant magneto-optical (GMO) or Faraday effect in iron garnets, they with a magnetic field of a few hundred Gauss, (20 mT) for an interaction length for an optical beam of a few millimeters achieve a polarization rotation or phase shift of 45 deg (1/8 cycle). When powered by a small laser diode, with the induced linear phase shift recovered at the shot noise limit, we have demonstrated sensitivities at the 3.3 nT/Hz1/2 level for frequencies from less than 1 Hz to frequencies into the high kHz range. Through further improvements; an increase in interaction length, better materials and by far the greatest factor, the addition of a flux concentrator, sensitivities at the pT/Hz1/2 level appear to be within reach. We will detail such a design and discuss the issues that may limit achieving these goals.

77 FR 5005 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... Due: 5 p.m. ET 1/31/12. Docket Numbers: RP12-322-000. Applicants: Gulf Crossing Pipeline Company LLC.../2011. Filed Date: 1/17/12. Accession Number: 20120117-5211. Comments Due: 5 p.m. ET 1/30/12. Docket.... Accession Number: 20120119-5105. Comments Due: 5 p.m. ET 1/31/12. Docket Numbers: RP12-319-000. Applicants...

77 FR 9912 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

....m. ET 3/2/12. Docket Numbers: ER12-743-001. Applicants: Black Hills Power, Inc. Description: GDEMA.... Comments Due: 5 p.m. ET 3/2/12. Docket Numbers: ER12-748-001. Applicants: Black Hills Power, Inc...: 20120210-5178. Comments Due: 5 p.m. ET 3/2/12. Docket Numbers: ER12-750-001. Applicants: Black Hills Power...

77 FR 34377 - Combined Notice of Filings

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2012-06-11

... Number: 20120601-5160. Comments Due: 5 p.m. ET 6/13/12. Docket Numbers: RP12-783-000. Applicants: ANR... Number: 20120601-5176. Comments Due: 5 p.m. ET 6/13/12. Docket Numbers: RP12-784-000. Applicants: Elba.... Filed Date: 6/1/12. Accession Number: 20120601-5183. Comments Due: 5 p.m. ET 6/13/12. Docket Numbers...

77 FR 12825 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

.... Accession Number: 20120223-5087. Comments Due: 5 p.m. ET 3/6/12. Docket Numbers: RP12-397-000. Applicants.../2012. Filed Date: 2/24/12. Accession Number: 20120224-5000. Comments Due: 5 p.m. ET 3/7/12. Docket.... Filed Date: 2/23/12. Accession Number: 20120223-5115. Comments Due: 5 p.m. ET 3/1/12. Any person...

75 FR 64367 - Sunshine Federal Register Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Week of November 1, 2010--Tentative... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting). (Contact: Michael Fuller, 301-415-0520.) This meeting will be...

75 FR 61227 - Sunshine Act: Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... on Security Issues (Closed--Ex. 1). Week of November 1, 2010--Tentative Tuesday, November 2, 2010 9..., 2010 1:30 p.m.--NRC All Employees Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m.--Briefing on Medical Issues (Public...

75 FR 62894 - Sunshine Federal Register Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-13

..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). Week of November 1, 2010... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting), (Contact: Michael Fuller, 301-415-0520). This meeting will be...

Irish Educational Studies, Vol. 5, Nos. 1 and 2, 1985.

ERIC Educational Resources Information Center

Coolahan, John, Ed.

1986-01-01

This issue of "Irish Educational Studies" focuses on curriculum and learning issues and includes: (1) "Aesthetic Perspectives in Curriculum Reform" (D. Murphy); (2) "Drama: Less Talk, More Action" (M. Drury); (3)" Out of Tune with Reality: Music and the School in Ireland" (M. O'Suilleabhain); (4)…

75 FR 49313 - Rules of Practice and Procedure

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-12

..., First Floor, on business days between 9 a.m. and 5 p.m. FOR FURTHER INFORMATION CONTACT: Charlotte A... for public inspection and copying at the address above on government-business days between the hours... to initiate proceedings to issue cease and desist orders, to issue temporary cease and desist orders...

Pharmacodynamic Effects of a 6-Hour Regimen of Enoxaparin in Patients Undergoing Primary Percutaneous Coronary Intervention (PENNY PCI Study).

PubMed

Sumaya, Wael; Parker, William A E; Fretwell, Rebekah; Hall, Ian R; Barmby, David S; Richardson, James D; Iqbal, Javaid; Adam, Zulfiquar; Morgan, Kenneth P; Gunn, Julian P; Mason, Annah E; Judge, Heather M; Gale, Christopher P; Ajjan, Ramzi A; Storey, Robert F

2018-06-06

Delayed onset of action of oral P2Y 12 inhibitors in ST-elevation myocardial infarction (STEMI) patients may increase the risk of acute stent thrombosis. Available parenteral anti-thrombotic strategies, to deal with this issue, are limited by added cost and increased risk of bleeding. We investigated the pharmacodynamic effects of a novel regimen of enoxaparin in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Twenty patients were recruited to receive 0.75 mg/kg bolus of enoxaparin (pre-PPCI) followed by infusion of enoxaparin 0.75 mg/kg/6 h. At four time points (pre-anti-coagulation, end of PPCI, 2-3 hours into infusion and at the end of infusion), anti-Xa levels were determined using chromogenic assays, fibrin clots were assessed by turbidimetric analysis and platelet P2Y 12 inhibition was determined by VerifyNow P2Y12 assay. Clinical outcomes were determined 14 hours after enoxaparin initiation. Nineteen of 20 patients completed the enoxaparin regimen; one patient, who developed no-reflow phenomenon, was switched to tirofiban after the enoxaparin bolus. All received ticagrelor 180 mg before angiography. Mean (± standard error of the mean) anti-Xa levels were sustained during enoxaparin infusion (1.17 ± 0.06 IU/mL at the end of PPCI and 1.003 ± 0.06 IU/mL at 6 hours), resulting in prolonged fibrin clot lag time and increased lysis potential. Onset of platelet P2Y 12 inhibition was delayed in opiate-treated patients. No patients had thrombotic or bleeding complications. In conclusion, enoxaparin 0.75 mg/kg bolus followed by 0.75 mg/kg/6 h provides sustained anti-Xa levels in PPCI patients. This may protect from acute stent thrombosis in opiate-treated PPCI patients who frequently have delayed onset of oral P2Y 12 inhibition. Schattauer GmbH Stuttgart.

40 CFR 130.12 - Coordination with other programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

....12 Section 130.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY PLANNING AND MANAGEMENT § 130.12 Coordination with other programs. (a) Relationship... 208(e) of the Act, no NPDES permit may be issued which is in conflict with an approved Water Quality...

Influence of Human Factor Issues on Patient-Centered mHealth Apps' Impact; Where Do We Stand?

PubMed

Wildenbos, G A; Peute, L W; Jaspers, M W M

2016-01-01

This paper discusses the preliminary results of a literature review on studies published in 2014-2015 concerning patient-centered mHealth applications' (apps) impact. Abstracts were included when they described a mHealth app targeted at patients and reported on the effects of this app on patient care. From a total of 559 potentially relevant articles, 17 papers were finally included. Nine studies reported a positive impact of the patient-centered mHealth app on patient care; 4 of these studies were randomized controlled trials. Measured impacts in the 17 studies focused on improving patients' physical activity, self-efficacy and medication adherence. Human factors issues potentially mediating these effects were discussed in all studies. Transitions in the interaction between healthcare providers and their patients were most often discussed as influencing the impact of the mHealth app. More research is needed, focussing on human issues mediating the effect of patient-centered mHealth apps to precipitate knowledge on the effectiveness of mHealth. This research should preferably be guided by socio-technical models.

USSR Space Life Sciences Digest, issue 12

NASA Technical Reports Server (NTRS)

Hooke, Lydia Razran (Editor); Radtke, Mike (Editor); Teeter, Ronald (Editor); Rowe, Joseph (Editor)

1987-01-01

This issue contains 42 papers recently published in Russian language periodicals and bound collections of four Soviet monographs. Also included is a review of a recent Soviet congress on space gastroenterology.

MBEA Today. Volume LVI. Issues 1-5.

ERIC Educational Resources Information Center

MBEA Today, 1991

1991-01-01

This packet contains five issues of "MBEA Today," the official publication of the Michigan Business Education Association, issued from September 1990 through September 1991. Articles in issue 1 include the following: "MBEA Presents Position Statements to Michigan State Board of Education" (Ann M. Remp); "Adult Education:…

The Constitutionality of the K-12 Funding System in Illinois, Volume I: Legal Issues. MacArthur/Spencer Series Number 3.

ERIC Educational Resources Information Center

Franklin, David L.; And Others

This is volume I of a two-volume study of the constitutionality of the K-12 funding system in Illinois. In this volume, seven steps are presented in the issues and outcomes of the major judicial challenges to systems of state aid to public schools. The first chapter looks at the history of state aid litigation up to the time California became the…

Thinking About Thinking: Enhancing Creativity and Understanding in Operational Planners

DTIC Science & Technology

2012-06-08

34An Experimental Method for Measuring the Emergence,” 462. 19Arthur J. Cropley , “Defining and Measuring Creativity: Are Creativity Tests Worth Using...Creativity and Affect in Fantasy in Children”, Creativity Research Journal Volume 12, Issue 2 (1999): 134; Cropley , 72. 117Helson, Ravenna Helson, “A...Longitudinal Study of Creative Personality in Women,” Creativity Research Journal Volume 12, Issue 2 (1999): 89; Cropley , 78. 118Lubart, “Models of

Interpreting the Subtle Spectral Variations of the 11.2 and 12.7 μm Polycyclic Aromatic Hydrocarbon Bands

NASA Astrophysics Data System (ADS)

Shannon, M. J.; Stock, D. J.; Peeters, E.

2016-06-01

We report new properties of the 11 and 12.7 μm emission complexes of polycyclic aromatic hydrocarbons (PAHs) by applying a Gaussian-based decomposition technique. Using high-resolution Spitzer Space Telescope data, we study in detail the spectral and spatial characteristics of the 11 and 12.7 μm emission bands in maps of reflection nebulae NGC 7023 and NGC 2023 (north and south) and the star-forming region M17. Profile variations are observed in both the 11 and 12.7 μm emission bands. We identify a neutral contribution to the traditional 11.0 μm PAH band and a cationic contribution to the traditional 11.2 μm band, the latter of which affects the PAH class of the 11.2 μm emission in our sample. The peak variations of the 12.7 μm complex are explained by the competition between two underlying blended components. The spatial distributions of these components link them to cations and neutrals. We conclude that the 12.7 μm emission originates in both neutral and cationic PAHs, lending support to the use of the 12.7/11.2 intensity ratio as a charge proxy.

22 CFR 230.12 - Prosecution of claims.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Prosecution of claims. 230.12 Section 230.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.12...

22 CFR 230.12 - Prosecution of claims.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Prosecution of claims. 230.12 Section 230.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.12...

22 CFR 230.12 - Prosecution of claims.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Prosecution of claims. 230.12 Section 230.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.12...

22 CFR 230.12 - Prosecution of claims.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Prosecution of claims. 230.12 Section 230.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.12...

10 CFR 218.12 - Pricing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Pricing. 218.12 Section 218.12 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.12 Pricing. The price for oil subject to a supply order issued pursuant to this subpart shall be based on the price conditions...

22 CFR 230.12 - Prosecution of claims.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Prosecution of claims. 230.12 Section 230.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.12...

21 CFR 12.93 - Summary decisions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Summary decisions. 12.93 Section 12.93 Food and... PUBLIC HEARING Hearing Procedures § 12.93 Summary decisions. (a) After the hearing commences, a participant may move, with or without supporting affidavits, for a summary decision on any issue in the...

Teaching Social Issues in the English Classroom.

ERIC Educational Resources Information Center

Totten, Samuel, Ed.

1986-01-01

Focusing on the rationales and materials for teaching social issues in the English classroom, this thematic issue contains the following articles: "Introduction: Reflections of Society in Literature" (M. B. Fleming); "Addressing Social and/or Controversial Issues in the English Classroom" (S. Totten); "The Growing Threat to Quality Education: How…

Irish Educational Studies, 1988.

ERIC Educational Resources Information Center

McKernan, Jim, Ed.

1988-01-01

A total of 25 papers are included in the two issues of this series (12 in issue number 1; 13 in issue number 2), as follows: (1) "Recent Trends in Teacher Education in England" (V. McClelland); (2) "American Educational Reform: Is the Cure Worse Than the Disease" (R. Barger); (3) "Professional Attitudes" (G. Gaden);…

Adolescents with Chronic Illnesses--Issues for School Personnel. Second Edition. CYDLINE Reviews.

ERIC Educational Resources Information Center

Minnesota Univ., Minneapolis. National Center for Youth with Disabilities.

This resource guide covers the psychosocial and health concerns of adolescents with chronic illnesses. In a section titled "Bibliographic Information," the guide describes 12 books on general medical and social aspects, three resources on demographics, four resources on school issues, and 14 resources on psychosocial and family issues. A section…

Products and Services Notice - Naval Oceanography Portal

Science.gov Websites

Tropical Cyclone Formation Alert, Northwest Pacific Ocean Issued as required when tropical cyclone PGTW Tropical Cyclone Formation Alert, North Indian Ocean Issued as required when TC formation is , Southwest Pacific Ocean Issued as required when TC formation is expected in 12-24 hours WTPS31-35 PGTW

The Impact of Converging Information Technologies. Proceedings of the CAUSE National Conference (Monterey, California, December 9-12, 1986).

ERIC Educational Resources Information Center

CAUSE, Boulder, CO.

Proceedings of a 1986 CAUSE conference on the impact of converging information technologies are presented. Topics of conference papers include: policy issues in higher education, planning and information technology, people issues in information technology, telecommunications/networking, special environments, microcomputer issues and applications,…

Issues and Concerns Faced by Undergraduate Language Student Teachers during Teaching Practicum Experiences

ERIC Educational Resources Information Center

Ali, Mohd Sofi; Othman, Abdul Jalil; Karim, Abdul Faruk Abdul

2014-01-01

This study examined specific issues and concerns faced by Bachelor of Education student teachers majoring in Language and Literature during their 12-week teaching practicum experience. Specifically, three main areas of concerns were examined. They were: (1) specific issues and concerns related to the implementation of teaching practicum faced by…

Individual Learning Issues. Symposium 44. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

ERIC Educational Resources Information Center

2000

This document contains three papers from a symposium on individual learning issues that was conducted as part of a conference on human resource development (HRD). "Communication in the Workplace: Using Myers-Briggs To Build Communication Effectiveness" (Patrice M. Scanlon, Judy K. Schmitz, Tracey Murray, Lisa M. Hooper) reports on a…

76 FR 22386 - Western Pacific Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-21

..., April 26, 2011, 9 a.m.-5 p.m. 1. Introductions. 2. Review of CDPP and Marine Education and Training (MET... Advisory Panel will meet as late as necessary to complete scheduled business. Although non-emergency issues... subject of formal action during these meetings. Action will be restricted to those issues specifically...

77 FR 69837 - SFIREG Full Committee; Notice of Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... Association of American Pesticide Control Officials (AAPCO)/State FIFRA Issues Research and Evaluation Group... topics. DATES: The meeting will be held on Monday, December 10, 2012, from 8:30 a.m. to 5 p.m. and...://www.epa.gov/dockets . II. Tentative Agenda Topics 1. Responses to SFIREG Pyrethroid labeling issue...

12 CFR 925.23 - Excess stock.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the form of additional shares of Bank stock or otherwise issue any excess stock. A Bank shall not issue excess stock, as a dividend or otherwise, if after the issuance, the outstanding excess stock at...

Autofluorescence-Free Live-Cell Imaging Using Terbium Nanoparticles.

PubMed

Cardoso Dos Santos, M; Goetz, J; Bartenlian, H; Wong, K-L; Charbonnière, L J; Hildebrandt, N

2018-04-18

Fluorescent nanoparticles (NPs) have become irreplaceable tools for advanced cellular and subcellular imaging. While very bright NPs require excitation with UV or visible light, which can create strong autofluorescence of biological components, NIR-excitable NPs without autofluorescence issues exhibit much lower brightness. Here, we show the application of a new type of surface-photosensitized terbium NPs (Tb-NPs) for autofluorescence-free intracellular imaging in live HeLa cells. The combination of exceptionally high brightness, high photostability, and long photoluminecence (PL) lifetimes for highly efficient suppression of the short-lived autofluorescence allowed for time-gated PL imaging of intracellular vesicles over 72 h without toxicity and at extremely low Tb-NP concentrations down to 12 pM. Detection of highly resolved long-lifetime (ms) PL decay curves from small (∼10 μm 2 ) areas within single cells within a few seconds emphasized the unprecedented photophysical properties of Tb-NPs for live-cell imaging that extend well beyond currently available nanometric imaging agents.

KSC-2010-5887

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Kim Shiflett

KSC-2010-5888

NASA Image and Video Library

2010-12-21

CAPE CANAVERAL, Fla. -- Space shuttle Discovery awaits its move, called rollback, from Launch Pad 39A to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. Rollback was scheduled for 12:30 a.m., but was postponed until 10 p.m. so technicians could resolve an issue with a leveling system on the crawler-transporter. Once inside the VAB, Discovery's external fuel tank will be examined and foam reapplied where 89 sensors were installed on the tank's aluminum skin for an instrumented tanking test on Dec. 17. The sensors were used to measure changes in the tank as super-cold propellants were pumped in and drained out. Data and analysis from the test will be used to determine what caused the tops of two, 21-foot-long support beams, called stringers, on the outside of the intertank to crack during fueling on Nov. 5. Discovery's next launch opportunity is no earlier than Feb. 3, 2011. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Kim Shiflett

Trust and British Gas partner in EPC scheme.

PubMed

Bevan, Patrick

2015-02-01

In late August last year the St George's Healthcare NHS Trust in south-west London signed what the Trust's Estates and Facilities team described as 'a historic partnership' with British Gas for a £12 m Energy Performance Contract energy reduction scheme--via which the energy company has guaranteed to deliver £1.1 m in annual savings over the next 15 years. The agreement will see British Gas replace four 35-year-old gas-powered steam boilers and an ageing CHP plant in the boiler house at the Trust's main acute facility, the StGeorge's Hospital in Tooting, and upgrade some of the associated infrastructure. British Gas will also maintain the new plant to ensure that the projected savings are achieved while the Trust owns the new assets. The Trust should gain financially--via lower energy costs and carbon emissions, while estates personnel will be better able to complete the many other estate maintenance issues that would otherwise be contracted out at one of London's biggest acute hospitals.

A simple relation between the gamma N -> N(1535) helicity amplitudes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilberto Ramalho, Kazuo Tsushima

2011-09-01

It is shown that the helicity amplitudes A{sub 1/2} and S{sub 1/2} in the {gamma}N {yields} N(1535) reaction, can be well related by S{sub 1/2} = {radical}1+{tau}/{radical}2 M{sub S}{sup 2}-M{sup 2}/2M{sub S}Q A{sub 1/2} in the region Q{sup 2} > 2 GeV{sup 2}, where M and M{sub S} are the nucleon and N(1535) masses, q{sup 2} = -Q{sup 2} the four-momentum transfer squared, and {tau} = Q{sup 2}/(M{sub S} + M){sup 2}. This follows from the fact that the Pauli-type transition form factor F*{sub 2} extracted from the experimental data, turns up to show F*{sub 2} {approx_equal} 0 for Q{supmore » 2} > 1.5 GeV{sup 2}. The observed relation is tested by the experimental data and the MAID parametrization. A direct consequence of the relation is that the assumption,|A{sub 1/2}| >> |S{sub 1/2}|, is not valid for high Q{sup 2}. Instead, both amplitudes A{sub 1/2} and S{sub 1/2} have the same Q{sup 2} dependence in the high Q{sup 2} region, aside from that S{sub 1/2} has an extra factor, - 1/{radical} M{sub S}-M/2M{sub s}. The origin of this relation is interpreted in a perspective of a quark model.« less

Temps d'Educacio. Revista de la Divisio de Ciencies de l'Educacio (Educational Times. Journal of the Education Sciences Department. Volumes 1 & 2).

ERIC Educational Resources Information Center

Temps d'Educacio, 1989

1989-01-01

Each of the 12 issues of this Catalan-language journal offers book reviews and articles on general issues in education. Some issues contain a Spanish-language translation of the Catalan articles; issues 3 and later contain only Spanish-, English- and French-language abstracts of included articles with keyword references. Number 1 (1st. semester…

Safety of laboratory analyzers for infection testing - results of the market surveillance by the BfArM until end 2007

PubMed Central

2009-01-01

The European Directive 98/79/EC on in vitro diagnostic medical devices (IVD) stipulates the marketing and post market surveillance of IVD in the European Economic Area. In cases of issues and field corrective actions, the manufacturers have to inform the responsible Competent Authorities (CA). In Germany, the Federal Institute for Drugs and Medical Devices (BfArM) is the responsible CA for most IVD, with a small subset of IVD for immune hematological and infectiological testing as well as tissue typing as specified in Annex II of the Directive, being within the responsibility of the Paul-Ehrlich-Institute (PEI). In this study, all issues regarding laboratory analyzers for infection testing and their consumables, but not reagents, kits and general culture media, reported to the BfArM between begin 1999 and end of 2007 were analyzed in respect to the sources of report, the underlying product failure and the performed corrective actions. Within the observation period a total of 1471 reports for IVD were received of which 73 related to the IVD for infection testing were included in our study. Reports were predominantly received from manufacturers (56) and competent authorities (15). Affected products were most frequently those for immunological analysis (42) whereas those based on culturing techniques (17) and molecular biological techniques (14) played only minor roles. In all these groups, laboratory analyzers (55) were more frequently affected than their consumables (18). Investigations of the manufacturers were able to identify the underlying root causes of product failures in 62 cases (84.9%). In 2 cases (2.7%) the root cause remained unclear and in 9 cases (12.3%) a product failure was excluded or a user error was the underlying cause. Product failures in laboratory analyzers were most frequently caused by software errors (31) and constructional faults (8) whereas the predominant cause of product failure in consumables were errors in production and quality control (8). Manufacturers issued corrective measures in 66 cases (90.4%) from which 49 and 17 were related to laboratory analyzers and their consumables, respectively. Based on the underlying root causes of product failures these were predominantly customer information (48), recalls (40), software-updates (30) and design changes (9) in the product group of laboratory analyzers as well as customer information (16), recalls (12) and modifications of production and quality management (11) in the group of consumables. The results and experiences obtained since 1999 suggest that the system for post marketing surveillance of IVD is an established tool to ensure product safety, even though the current system can be further enhanced. PMID:20156760

The impact of a lifestyle change program on the mental health of obese under-served African American women.

PubMed

Groh, Carla J; Urbancic, Joan C

2015-04-01

Obesity is a critical social and health issue, adversely impacting life expectancy, quality of life, and mental health. Minorities are disproportionately impacted by obesity with African Americans experiencing the highest prevalence among minority groups. The aim of this study was to determine if a lifestyle program that integrated chair exercises, nutrition and educational counseling, and scripture readings would help under-served obese African American women make lifestyle changes that would positively impact their quality of life, especially mental health. A repeated measures intervention study was conducted (24-weeks). Weeks 1-12 involved meeting twice a week for a total of 4h with participants engaged in chair exercises, educational counseling, and scripture readings. During weeks 13-24, the participants were "on their own" but were encouraged to exercise and eat healthy. Focus groups were held at 12 and 24-weeks. Participants were recruited from a nurse managed center and a primary care clinic for the uninsured. Mental health data were collected at baseline, 12, and 24-weeks. The Medical Outcomes Study Short Form Version 2 (SF-36v2) was used to measure changes in mental health. Higher scores indicate better perceived health status. Group scores less than 47 indicate impaired functioning. 55 women had complete data for all three data collection points, with a mean age of 50 and a mean BMI of 41.2. Repeated ANOVAs detected significant differences on the mental component summary of the SF-36v2: this score improved from baseline (M=44.1) to 12-weeks (M=50.7) but decreased at 24-weeks (M=47.9) (p=.000). The four domains (vitality, social functioning, role emotional, mental health) were also significantly different over the three data collection points. The findings have significant implications for psychiatric nurses in terms of education, clinical practice, and future research. The study contributed to the participants' mental health through the various group activities including scripture readings, socialization with "like minded" women and structured exercises. These findings offer psychiatric nurses additional tools for effective care. Copyright © 2014 Elsevier Inc. All rights reserved.

A Burning Desire: A Focus Group Turns Its Attention to Old Glory. 12th Grade Lesson. Schools of California Online Resources for Education (SCORE): Connecting California's Classrooms to the World.

ERIC Educational Resources Information Center

MacDonald, David

This lesson for grade 12 is designed to increase student awareness of the debate surrounding flag burning, the proposed constitutional amendment to prohibit flag burning, and the constitutional issues involved, specifically the First Amendment. Students play the role of staff members for a U.S. Senator. They research the issue and prepare both pro…

Prevenir y Combatir El Acoso en La Escuela: Guia de Recursoso para Educadores de los Grados "K" al Grado "12" (Preventing and Countering School-Based Harassment: A Resource Guide for K-12 Educators).

ERIC Educational Resources Information Center

Steineger, Melissa

This guide focuses on the issue of school-based harassment. It is intended to help educators prevent or curtail all forms of harassment by highlighting school-based harassment issues, by describing remedies and prevention strategies, and by providing additional resources. It details some of the problems school-based harassment engenders, and it…

CTC Sentinel. Volume 6, Issue 11-12, November 2013

DTIC Science & Technology

2013-11-01

Libyan government today seeks only to strengthen its existence and power through presenting loyalty to these belligerent countries and offering...opened fire at customs police in Port Said near the Suez Canal, killing one person. – Bloomberg October 8 October 8, 2013 (IRAQ): A car bomb exploded...in front of a restaurant in the mainly Shi`a neighborhood of Zafaraniyya, killing three people. – AP, October 8 NOvEMBER 2013 . VoL 6. IssUE 11-12

Diagnostics for the optimization of an 11 keV inverse Compton scattering x-ray source

NASA Astrophysics Data System (ADS)

Chauchat, A.-S.; Brasile, J.-P.; Le Flanchec, V.; Nègre, J.-P.; Binet, A.; Ortega, J.-M.

2013-04-01

In a scope of a collaboration between Thales Communications & Security and CEA DAM DIF, 11 keV Xrays were produced by inverse Compton scattering on the ELSA facility. In this type of experiment, X-ray observation lies in the use of accurate electron and laser beam interaction diagnostics and on fitted X-ray detectors. The low interaction probability between < 100 μm width, 12 ps [rms] length electron and photon pulses requires careful optimization of pulse spatial and temporal covering. Another issue was to observe 11 keV X-rays in the ambient radioactive noise of the linear accelerator. For that, we use a very sensitive detection scheme based on radio luminescent screens.

Transpiration and whole-tree conductance in ponderosa pine trees of different heights.

PubMed

Ryan, M G; Bond, B J; Law, B E; Hubbard, R M; Woodruff, D; Cienciala, E; Kucera, J

2000-09-01

Changes in leaf physiology with tree age and size could alter forest growth, water yield, and carbon fluxes. We measured tree water flux (Q) for 14 ponderosa pine trees in two size classes (12 m tall and ∼40 years old, and 36 m tall and ∼ 290 years old) to determine if transpiration (E) and whole-tree conductance (g t ) differed between the two sizes of trees. For both size classes, E was approximately equal to Q measured 2 m above the ground: Q was most highly correlated with current, not lagged, water vapor pressure deficit, and night Q was <12% of total daily flux. E for days 165-195 and 240-260 averaged 0.97 mmol m -2 (leaf area, projected) s -1 for the 12-m trees and 0.57 mmol m -2 (leaf area) s -1 for the 36-m trees. When photosynthetically active radiation (I P ) exceeded the light saturation for photosynthesis in ponderosa pine (900 µmol m -2 (ground) s -1 ), differences in E were more pronounced: 2.4 mmol m -2 (leaf area) s -1 for the 12-m trees and 1.2 mmol m -2 s -1 for the 36-m trees, yielding g t of 140 mmol m -2 (leaf area) s -1 for the 12-m trees and 72 mmol m -2 s -1 for the 36-m trees. Extrapolated to forests with leaf area index =1, the 36-m trees would transpire 117 mm between 1 June and 31 August compared to 170 mm for the 12-m trees, a difference of 15% of average annual precipitation. Lower g t in the taller trees also likely lowers photosynthesis during the growing season.

Reactive Collision Avoidance of UAVs withStereovision Sensing

DTIC Science & Technology

2014-01-17

terms of homogeneous coordinates. Mxw = 0 Where M =  m11 m12 m13 m14 m21 m22 m23 m24 m31 m32 m33 m34 m41 m42 m43 m44  (4.15) 50 m11 = p11 − xp...1 p31 , m12 = p12 − xp 1 p32 m13 = p13 − xp 1 p33 , m14 = p14 − xp 1 p34 m21 = p21 − yp 1 p31 , m22 = p22 − yp 1 p32 m23 = p23 − yp 1 p33 , m24 = p24

Dolutegravir-lamivudine as initial therapy in HIV-1 infected, ARV-naive patients, 48-week results of the PADDLE (Pilot Antiretroviral Design with Dolutegravir LamivudinE) study.

PubMed

Cahn, Pedro; Rolón, María José; Figueroa, María Inés; Gun, Ana; Patterson, Patricia; Sued, Omar

2017-05-09

A proof-of-concept study was designed to evaluate the antiviral efficacy, safety and tolerability of a two-drug regimen with dolutegravir 50 mg once daily (QD) plus lamivudine 300 mg once daily as initial highly active antiretroviral therapy (HAART) among antiretroviral (ARV)-naive patients. PADDLE is a pilot study including 20 treatment-naive adults. To be selected, participants had no IAS-USA-defined resistance, HIV-1 RNA ≤100,000 copies/mL at screening and negative HBsAg. Plasma viral load (pVL) was measured at baseline; days 2, 4, 7, 10, 14, 21 and 28; weeks 6, 8 and 12; and thereafter every 12 weeks up to 96 weeks. Primary endpoint was the proportion of patients with HIV-1 RNA <50 copies/mL in an intention to treat (ITT)-exposed analysis at 48 weeks (the FDA snapshot algorithm). Median HIV-1 RNA at entry was 24,128 copies/mL (interquartile range (IQR): 11,686-36,794). Albeit as per protocol, all patients had pVL ≤100,000 copies/mL at screening as required by inclusion criteria, four patients had ≥100,000 copies/mL at baseline. Median baseline CD4+ T-cell count was 507 per cubic millimetre (IQR: 296-517). A rapid decline in pVL was observed (median VL decay from baseline to week 12 was 2.74 logs). All patients were suppressed at week 8 onwards up to week 24. At week 48, 90% (18/20) reached the primary endpoint of a pVL <50 copies/mL. Median change in CD4 cell count between baseline and week 48 was 267 cells/mm 3 (IQR: 180-462). No major tolerability/toxicity issues were observed. Nineteen patients completed 48 weeks of the study, and one patient (with undetectable VL at last visit) committed suicide. One patient presented a low-level protocol-defined confirmed virological failure at week 36, being the only observed failure. This patient had pVL <50 copies/mL at the end-of-study visit without having changed the two-drug regimen. Observed failure rate was 5%. This is the first report of integrase strand transfer inhibitor/lamivudine dual regimen in ARV-naive patients. This novel dual regimen of dolutegravir and lamivudine warrants further clinical research and consideration as a potential therapeutic option for ARV-therapy-naive patients. NCT02211482.

Horticultural, systems-engineering and economic evaluations of short-term plant storage techniques as a labor management tool for vegetable grafting nurseries

PubMed Central

Son, Young-Jun; Lewis, Myles; Spalholz, Hans; Tronstad, Russell

2017-01-01

This transdisciplinary study has a three-fold systems approach in evaluating a horticultural technology: 1) horticultural evaluations, 2) economic and resource analyses, and 3) systems engineering analyses, using low temperature storage as an example technology. Vegetable grafting is a technique to produce value-added seedlings but requires labor intensive nursery operations. Low temperature storage of seedlings for a short period of time can reduce peak production, but has not been evaluated at the extent demonstrated in this paper. Seedlings of 22 genotypes of Cucurbitaceae (cucurbit family) and Solanaceae (nightshade family) were evaluated for storability under selected temperatures and photosynthetic photon flux. Storability of Cucurbitaceous seedlings varied between 2 to 4 weeks at 12°C and 13 μmol m-2 s-1. Solanaceous seedlings were generally storable for 4 weeks at 12°C and 13 μmol m-2 s-1, but tomato seedlings could be stored for 4 weeks at 10°C and 5 μmol m-2 s-1. Capital and weekly operational costs of a low temperature storage system with a design that meets environmental requirements were estimated as $671 to $708 per m2 footprint and $0.79 to $2.21 per m2 footprint per week, respectively. Electricity costs per plant was less than 0.1 cents for 2 to 4 weeks of storage. Using a schedule-optimization heuristic and a logistics simulator previously developed for grafting nursery operations, six production scenarios consisting of two crops (tomato or watermelon) and three production peak patterns were examined to evaluate the impact of including low temperature storage. While the overall average costs of grafting labor were not significantly different, maximum labor demand and grafting labor cost during the peak production week were reduced by 31% to 50% and 14% to 30% by using storage, respectively. Therefore, low temperature storage can be an effective means to address the issue of labor management in grafting nurseries. PMID:28182757

Solubility limits of dibutyl phosphoric acid in uranium-nitric acid solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, R.A.

2000-01-04

The Savannah River Site has enriched uranium (EU) solution that has been stored since being purified in its solvent extraction processes. The concentrations in solution are approximately 6 g/L U and 0.1 M nitric acid. Residual tributylphosphate in solution has slowly hydrolyzed to form dibutyl phosphoric acid (HDBP) at concentrations averaging 30--50 mg/L. Dibutyl phosphoric acid, in turn, is in equilibrium with (HDBP){sub 2} and DBP{sup {minus}}. Uranium can form compounds with the dibutylphosphate ion (DBP{sup {minus}}) which have limited solubility, thereby creating a nuclear criticality safety issue. Literature reports and earlier SRTC tests have shown that it is feasiblemore » to precipitate U-DBP solid during the storage and processing of EU solutions. As a result, a series of solubility experiments were run at nitric acid concentrations from 0--4.0 M HNO{sub 3}, uranium at 0--90 g/L, and temperatures from 0--30 C. The data shows temperature and nitric acid concentration dependence consistent with what would be expected. With respect to uranium concentration, U-DBP solubility passes through a minimum between 6 and 12 g/L U at the acid concentrations and temperatures studied. However, the minimum shows a slight shift toward lower uranium concentrations at lower nitric acid concentrations. The shifts in solubility are strongly dependent upon the overall ionic strength of the solution. The data also reveal a shift to higher DBP solubility above 0.5 M HNO{sub 3} for both 6 g/L and 12 g/L uranium solutions. Analysis of U-DBP solids from the tests identified distinct differences between precipitates from less than 0.5 M solutions and those from greater than 4 M acid. Analyses identified UO{sub 2}(DBP){sub 2} as the dominant compound present at low acid concentrations in accordance with literature reports. As the acid concentration increases, the crystalline UO{sub 2}(DBP){sub 2} shows molecular substitutions and an increase in amorphous content.« less

Increasing temperature speeds intracellular PO2 kinetics during contractions in single Xenopus skeletal muscle fibers.

PubMed

Koga, S; Wüst, R C I; Walsh, B; Kindig, C A; Rossiter, H B; Hogan, M C

2013-01-01

Precise determination of the effect of muscle temperature (T(m)) on mitochondrial oxygen consumption kinetics has proven difficult in humans, in part due to the complexities in controlling for T(m)-related variations in blood flow, fiber recruitment, muscle metabolism, and contractile properties. To address this issue, intracellular Po(2) (P(i)(O(2))) was measured continuously by phosphorescence quenching following the onset of contractions in single Xenopus myofibers (n = 24) while controlling extracellular temperature. Fibers were subjected to two identical contraction bouts, in random order, at 15°C (cold, C) and 20°C (normal, N; n = 12), or at N and 25°C (hot, H; n = 12). Contractile properties were determined for every contraction. The time delay of the P(i)(O(2)) response was significantly greater in C (59 ± 35 s) compared with N (35 ± 26 s, P = 0.01) and H (27 ± 14 s, P = 0.01). The time constant for the decline in P(i)(O(2)) was significantly greater in C (89 ± 34 s) compared with N (52 ± 15 s; P < 0.01) and H (37 ± 10 s; P < 0.01). There was a linear relationship between the rate constant for P(i)(O(2)) kinetics and T(m) (r = 0.322, P = 0.03). Estimated ATP turnover was significantly greater in H than in C (P < 0.01), but this increased energy requirement alone with increased T(m) could not account for the differences observed in P(i)(O(2)) kinetics among conditions. These results demonstrate that P(i)(O(2)) kinetics in single contracting myofibers are dependent on T(m), likely caused by temperature-induced differences in metabolic demand and by temperature-dependent processes underlying mitochondrial activation at the start of muscle contractions.

50 CFR 697.12 - At-sea sea sampler/observer coverage.

Code of Federal Regulations, 2010 CFR

2010-10-01

... may request any vessel issued a Federal limited access American lobster permit to carry a NMFS... issued a Federal limited access American lobster permit, if requested by the sea sampler/observer also...

50 CFR 697.12 - At-sea sea sampler/observer coverage.

Code of Federal Regulations, 2011 CFR

2011-10-01

... may request any vessel issued a Federal limited access American lobster permit to carry a NMFS... issued a Federal limited access American lobster permit, if requested by the sea sampler/observer also...

Lamb shift and fine structure at n =2 in a hydrogenlike muonic atom with the nuclear spin I =0

NASA Astrophysics Data System (ADS)

Korzinin, Evgeny Yu.; Shelyuto, Valery A.; Ivanov, Vladimir G.; Karshenboim, Savely G.

2018-01-01

The paper is devoted to the Lamb shift and fine structure in a hydrogenlike muonic atom with a spinless nucleus up to the order α5m with all the recoil corrections included. Enhanced contributions of a higher order are also considered. We present the results on the pure QED contribution and on the finite-nuclear-size contribution, proportional to RN2, with the higher-order corrections included. We also consider the consistency of the pure QED theory and the evaluation of the nuclear-structure effects. Most of the QED theory is the same as the theory for the case of the nuclear spin 1/2. Additional nuclear-spin-dependent terms are considered in detail. The issue of the difference for the theories with a spinor nucleus and a scalar one is discussed for the recoil contributions in the order (Zα ) 4m ,α (Zα ) 4m , and (Zα ) 5m . The numerical results are presented for the muonic atoms with two lightest scalar nuclei, helium-4 and beryllium-10. We compare the theory of those muonic atoms with theory for the muonic hydrogen. Some higher-order finite-nuclear-size corrections for the Lamb shift in muonic hydrogen are revisited.

Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines.

PubMed

Antal, A; Alekseichuk, I; Bikson, M; Brockmöller, J; Brunoni, A R; Chen, R; Cohen, L G; Dowthwaite, G; Ellrich, J; Flöel, A; Fregni, F; George, M S; Hamilton, R; Haueisen, J; Herrmann, C S; Hummel, F C; Lefaucheur, J P; Liebetanz, D; Loo, C K; McCaig, C D; Miniussi, C; Miranda, P C; Moliadze, V; Nitsche, M A; Nowak, R; Padberg, F; Pascual-Leone, A; Poppendieck, W; Priori, A; Rossi, S; Rossini, P M; Rothwell, J; Rueger, M A; Ruffini, G; Schellhorn, K; Siebner, H R; Ugawa, Y; Wexler, A; Ziemann, U; Hallett, M; Paulus, W

2017-09-01

Low intensity transcranial electrical stimulation (TES) in humans, encompassing transcranial direct current (tDCS), transcutaneous spinal Direct Current Stimulation (tsDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation or their combinations, appears to be safe. No serious adverse events (SAEs) have been reported so far in over 18,000 sessions administered to healthy subjects, neurological and psychiatric patients, as summarized here. Moderate adverse events (AEs), as defined by the necessity to intervene, are rare, and include skin burns with tDCS due to suboptimal electrode-skin contact. Very rarely mania or hypomania was induced in patients with depression (11 documented cases), yet a causal relationship is difficult to prove because of the low incidence rate and limited numbers of subjects in controlled trials. Mild AEs (MAEs) include headache and fatigue following stimulation as well as prickling and burning sensations occurring during tDCS at peak-to-baseline intensities of 1-2mA and during tACS at higher peak-to-peak intensities above 2mA. The prevalence of published AEs is different in studies specifically assessing AEs vs. those not assessing them, being higher in the former. AEs are frequently reported by individuals receiving placebo stimulation. The profile of AEs in terms of frequency, magnitude and type is comparable in healthy and clinical populations, and this is also the case for more vulnerable populations, such as children, elderly persons, or pregnant women. Combined interventions (e.g., co-application of drugs, electrophysiological measurements, neuroimaging) were not associated with further safety issues. Safety is established for low-intensity 'conventional' TES defined as <4mA, up to 60min duration per day. Animal studies and modeling evidence indicate that brain injury could occur at predicted current densities in the brain of 6.3-13A/m 2 that are over an order of magnitude above those produced by tDCS in humans. Using AC stimulation fewer AEs were reported compared to DC. In specific paradigms with amplitudes of up to 10mA, frequencies in the kHz range appear to be safe. In this paper we provide structured interviews and recommend their use in future controlled studies, in particular when trying to extend the parameters applied. We also discuss recent regulatory issues, reporting practices and ethical issues. These recommendations achieved consensus in a meeting, which took place in Göttingen, Germany, on September 6-7, 2016 and were refined thereafter by email correspondence. Copyright © 2017 International Federation of Clinical Neurophysiology. All rights reserved.

INTERPRETING THE SUBTLE SPECTRAL VARIATIONS OF THE 11.2 AND 12.7 μ m POLYCYCLIC AROMATIC HYDROCARBON BANDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shannon, M. J.; Stock, D. J.; Peeters, E., E-mail: mshann3@uwo.ca

2016-06-20

We report new properties of the 11 and 12.7 μ m emission complexes of polycyclic aromatic hydrocarbons (PAHs) by applying a Gaussian-based decomposition technique. Using high-resolution Spitzer Space Telescope data, we study in detail the spectral and spatial characteristics of the 11 and 12.7 μ m emission bands in maps of reflection nebulae NGC 7023 and NGC 2023 (north and south) and the star-forming region M17. Profile variations are observed in both the 11 and 12.7 μ m emission bands. We identify a neutral contribution to the traditional 11.0 μ m PAH band and a cationic contribution to the traditionalmore » 11.2 μ m band, the latter of which affects the PAH class of the 11.2 μ m emission in our sample. The peak variations of the 12.7 μ m complex are explained by the competition between two underlying blended components. The spatial distributions of these components link them to cations and neutrals. We conclude that the 12.7 μ m emission originates in both neutral and cationic PAHs, lending support to the use of the 12.7/11.2 intensity ratio as a charge proxy.« less

32 CFR 842.12 - HQ USAF claims responsibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administrative Management Program (CAMP) reviews. (2) Implements claims and tort litigation policies, issues... LITIGATION ADMINISTRATIVE CLAIMS Functions and Responsibilities § 842.12 HQ USAF claims responsibility. (a...

Towards Continuity in Cloud Properties from MODIS and Suomi-NPP Polar-Orbiting Sensors

NASA Astrophysics Data System (ADS)

Baum, B. A.; Menzel, P.; Gladkova, I.; Heidinger, A. K.

2015-12-01

The intent of this talk is to discuss the progress and issues involved with developing a continuous record of cloud properties since 1978, beginning with the High Resolution Infrared Radiation Sounder (HIRS), then MODIS on the NASA Terra/Aqua platforms, and into the future from merged CrIS and VIIRS data. The MODIS measurements include infrared (IR) window radiances at 8.5-, 11- and 12-μm and four 15-μm channels in the broad CO2 absorption band. Cloud top pressure/height and emissivity are derived using a technique in which the strength is in retrievals for mid-to-high clouds but less so for low clouds where there is little thermal contrast with the surface. Additionally, MODIS provides a decadal IR cloud phase product. The goal now is to extend this continuity from HIRS and MODIS to the S-NPP era. However, there is one large drawback to consider: VIIRS has no infrared (IR) absorption channels. The lack of at least one IR absorption channel on VIIRS degrades the accuracy of the cloud properties. There is a solution: we can construct a 13.3-μm channel from a combination of VIIRS and CrIS (Cross-track Infrared Sounder). The approach involves using the high spatial resolution VIIRS IR window channels in combination with a lower spatial resolution 13.3-μm channel derived using CrIS high spectral resolution measurements. The result is a 13.3-μm pseudo-channel at the VIIRS pixel spatial resolution of 750 m (i.e., M-band resolution). The radiometric accuracy of this approach was tested using MODIS and AIRS, and found to be within 1-2%. The availability of the pseudo-channel increases the potential for achieving continuity between MODIS and S-NPP. Since future platforms will likely continue with a pairing of an imager and hyperspectral sounder, this work lays a foundation for future cloud product continuity. We will show how the use of this new channel will impact the cloud height and phase products.

Factors associated with HCV risk practices in methadone-maintained patients: the importance of considering the couple in prevention interventions.

PubMed

Roux, Perrine; Lions, Caroline; Michel, Laurent; Mora, Marion; Daulouède, Jean-Pierre; Marcellin, Fabienne; Spire, Bruno; Morel, Alain; Carrieri, Patrizia M

2014-09-10

One important public health issue associated with opioid use today is the risk of hepatitis C (HCV) infection. Although methadone maintenance may help to decrease HCV-related risk practices, HCV risk behaviors persist and are strongly associated with specific substance use patterns, mental status and social context. The ANRS-Methaville study gave us the opportunity to better disentangle the different relationships between these various factors and HCV risk practices. The ANRS-Methaville multisite randomized trial was designed to assess the feasibility of initiating methadone in primary care by comparing it with methadone initiation in specialized centers. This study recruited 195 participants initiating methadone maintenance and followed up for 12 months. Longitudinal data from this trial was used to acquire a greater understanding of HCV risk practices and their pattern of correlates in this population. We selected 176 patients who had data on HCV risk practices at M0 and M12, accounting for 312 visits. HCV risk practices were defined as follows: sharing needles or syringes, sharing drug paraphernalia, getting a tattoo or having a piercing in a non-professional context, sharing toiletry items. To identify factors associated with HCV risk practices, we performed a mixed logistic regression analysis. HCV risk practices were reported by 19% and 15% of participants at baseline and M12, respectively. After adjustment for age, cocaine use and alcohol dependence as well as suicidal risk, living in a couple with a non-drug user and in a couple with a drug user were both independent predictors of HCV risk practices (OR[CI95%] = 4.16 [1.42-12.12]; OR[CI95%] = 9.85 [3.13-31.06], respectively). Identifying individuals at risk of HCV transmission during methadone treatment such as stimulant users, alcohol dependent individuals, and those at suicidal risk is necessary to optimize response to treatment. Innovative prevention approaches tailored to couples are also urgently needed and could decrease HCV-risk in this population. The trial is registered with the French Agency of Pharmaceutical Products (ANSM) under the number 2008-A0277-48, the European Union Drug Regulating Authorities Clinical Trials. Number Eudract 2008-001338-28, the ClinicalTrials.gov Identifier: NCT00657397 and the International Standard Randomised Controlled Trial Number Register ISRCTN31125511.

Factors associated with HCV risk practices in methadone-maintained patients: the importance of considering the couple in prevention interventions

PubMed Central

2014-01-01

Background One important public health issue associated with opioid use today is the risk of hepatitis C (HCV) infection. Although methadone maintenance may help to decrease HCV-related risk practices, HCV risk behaviors persist and are strongly associated with specific substance use patterns, mental status and social context. The ANRS-Methaville study gave us the opportunity to better disentangle the different relationships between these various factors and HCV risk practices. Methods The ANRS-Methaville multisite randomized trial was designed to assess the feasibility of initiating methadone in primary care by comparing it with methadone initiation in specialized centers. This study recruited 195 participants initiating methadone maintenance and followed up for 12 months. Longitudinal data from this trial was used to acquire a greater understanding of HCV risk practices and their pattern of correlates in this population. We selected 176 patients who had data on HCV risk practices at M0 and M12, accounting for 312 visits. HCV risk practices were defined as follows: sharing needles or syringes, sharing drug paraphernalia, getting a tattoo or having a piercing in a non-professional context, sharing toiletry items. To identify factors associated with HCV risk practices, we performed a mixed logistic regression analysis. Results HCV risk practices were reported by 19% and 15% of participants at baseline and M12, respectively. After adjustment for age, cocaine use and alcohol dependence as well as suicidal risk, living in a couple with a non-drug user and in a couple with a drug user were both independent predictors of HCV risk practices (OR[CI95%] = 4.16 [1.42-12.12]; OR[CI95%] = 9.85 [3.13-31.06], respectively). Conclusions Identifying individuals at risk of HCV transmission during methadone treatment such as stimulant users, alcohol dependent individuals, and those at suicidal risk is necessary to optimize response to treatment. Innovative prevention approaches tailored to couples are also urgently needed and could decrease HCV-risk in this population. The trial is registered with the French Agency of Pharmaceutical Products (ANSM) under the number 2008-A0277-48, the European Union Drug Regulating Authorities Clinical Trials. Number Eudract 2008-001338-28, the ClinicalTrials.gov Identifier: NCT00657397 and the International Standard Randomised Controlled Trial Number Register ISRCTN31125511. PMID:25209306

75 FR 44781 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

...; File No. 265-26] Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues AGENCY: Commodity... Meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting on August 11, 2010, from 9 a.m...

75 FR 66362 - Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

...; File No. 265-26] Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues AGENCY: Commodity... meeting of Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues. SUMMARY: The Joint CFTC-SEC Advisory Committee on Emerging Regulatory Issues will hold a public meeting on November 5, 2010, from 9 a.m...

Erratum: Erratum to: "The Sound Field of a Rotating Monopole in a Plug Flow"

NASA Astrophysics Data System (ADS)

Belyaev, I. V.

2018-01-01

The second equation in (9) should read: \\tilde p_m = [ C_m + iπ /2Q_m H_m^(1) ( Γ _2 r_0 ) ]J_m (Γ _2 r) + [ D_m - iπ /2Q_m J_m ( Γ _2 r_0 ) ]H_m^(1) ( Γ _2 r ), r_0 ≤ r ≤ R_0 Equation (21) should read: p_m = - ρ _0 c_0 q_0 G_m ( ξ _s )/π R_0 R√ 1 - M_1^2 sin ^2 θ × \\exp ( iRk_m /1 - M_1^2 [ √ 1 - M_1^2 sin ^2 θ - M_1 cos θ ] - i( ω _0 + mΩ )t - iπ m/2 ).

Long-Term (7 Years) Follow-Up of Roux-en-Y Gastric Bypass on Obese Adolescent Patients (<18 Years).

PubMed

Vilallonga, Ramon; Himpens, Jacques; van de Vrande, Simon

2016-01-01

Few data are available about obesity surgery in adolescent patients. To assess long-term outcomes after laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients <18 years. University Hospital, Europe. A retrospective study of prospectively collected data of patients <18 years (childhood group; ChG) (n = 28) treated by LRYGB of which 19 were available for follow-up between 2.4 and 10.2 years (mean 7.2 years). This group of patients was matched with an adult control group (AdG) of randomly chosen patients with similar characteristics who underwent LRYGB during the same period. The extensive survey included a telephonic questionnaire. 19 (12 females) of the 28 patients (67.9%) were available for follow-up. Preoperatively, 3 had type 2 diabetes mellitus (T2DM), 1 arterial hypertension, 5 dyslipidemia and 1 sleep apnea. In the ChG, average BMI after 7 years dropped from 38.9 kg/m2 preoperatively to 27.5 kg/m2. In the AdG, average BMI decreased from 39.4 to 27.1 kg/m2 in the same time period (nonsignificant between groups). One patient in the ChG needed a reoperation (internal hernia) versus 3 patients in the AdG (1 leak, 2 obstructions). All patients resolved their initial comorbidities. Two of 12 female patients in the ChG became pregnant 6 and 8 years after surgery, respectively, despite seemingly adequate oral contraception. Compliance with postoperative guidelines was good in 16/19 patients in ChG and in 14/18 patients in the AdG. Overall degree of satisfaction was high: 8.2/10 (SD 1.2, range 6-10) in the ChG and 8.9/10 (SD 1.7, range 5-10) in the AdG. LRYGB seems to be safe, provide good weight loss, and cure comorbidities in an adolescent population. Satisfaction degree is high. Inadvertent pregnancy despite conventional contraception is a possible issue. © 2016 S. Karger GmbH, Freiburg.

Density and rectangularity of planting influence 20-year growth and development of red alder.

Treesearch

Dean S. DeBell; Constance A. Harrington

2002-01-01

Red alder (Alnus rubra Bong.) seedlings were planted in northwestern Oregon, U.S.A., at five initial spacings: 0.6 × 1.2 m, 1.2 × 1.2 m, 1.2 × 1.8 m, 1.8 × 1.8 m, and 2.5 × 2.5 m. Up to about age 10, tree and stand characteristics were correlated primarily with initial planting density in the expected manner; through age 20, however, tree growth...

7 CFR 33.12 - Apples not subject to regulation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Apples not subject to regulation. 33.12 Section 33.12... REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Exemptions § 33.12 Apples not subject... this part, transport or receive for transportation to any foreign destination: (a) A quantity of apples...

7 CFR 33.12 - Apples not subject to regulation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Apples not subject to regulation. 33.12 Section 33.12... REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Exemptions § 33.12 Apples not subject... this part, transport or receive for transportation to any foreign destination: (a) A quantity of apples...

7 CFR 33.12 - Apples not subject to regulation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Apples not subject to regulation. 33.12 Section 33.12... REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Exemptions § 33.12 Apples not subject... this part, transport or receive for transportation to any foreign destination: (a) A quantity of apples...

7 CFR 33.12 - Apples not subject to regulation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Apples not subject to regulation. 33.12 Section 33.12... REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Exemptions § 33.12 Apples not subject... this part, transport or receive for transportation to any foreign destination: (a) A quantity of apples...

7 CFR 33.12 - Apples not subject to regulation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 2 2012-01-01 2012-01-01 false Apples not subject to regulation. 33.12 Section 33.12... REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT Exemptions § 33.12 Apples not subject... this part, transport or receive for transportation to any foreign destination: (a) A quantity of apples...

12 CFR 575.12 - Conversion or liquidation of mutual holding companies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Conversion or liquidation of mutual holding... MUTUAL HOLDING COMPANIES § 575.12 Conversion or liquidation of mutual holding companies. (a) Conversion... stock issued by the parent mutual holding company in connection with the conversion of the parent mutual...

FACT SHEET: EPA ISSUES UPDATED CANCER GUIDELINES AND SUPPLEMENTAL GUIDANCE ON RISKS FROM EARLY-LIFE EXPOSURE

EPA Science Inventory

March 29, 2005

FACT SHEET: 46 CFR 12.25-35 - Apprentice engineers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Apprentice engineers. 12.25-35 Section 12.25-35 Shipping... Department § 12.25-35 Apprentice engineers. (a) Persons enrolled in an apprentice engineer training program... evidence that they are so enrolled may be issued an endorsement as apprentice engineer and may be signed on...

46 CFR 12.25-35 - Apprentice engineers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Apprentice engineers. 12.25-35 Section 12.25-35 Shipping... Department § 12.25-35 Apprentice engineers. (a) Persons enrolled in an apprentice engineer training program... evidence that they are so enrolled may be issued an endorsement as apprentice engineer and may be signed on...

46 CFR 12.25-35 - Apprentice engineers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Apprentice engineers. 12.25-35 Section 12.25-35 Shipping... Department § 12.25-35 Apprentice engineers. (a) Persons enrolled in an apprentice engineer training program... evidence that they are so enrolled may be issued an endorsement as apprentice engineer and may be signed on...

46 CFR 12.25-35 - Apprentice engineers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Apprentice engineers. 12.25-35 Section 12.25-35 Shipping... Department § 12.25-35 Apprentice engineers. (a) Persons enrolled in an apprentice engineer training program... evidence that they are so enrolled may be issued an endorsement as apprentice engineer and may be signed on...

40 CFR 209.12 - Time.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Time. 209.12 Section 209.12 Protection... Issued Under Section 11(d) of the Noise Control Act § 209.12 Time. (a) In computing any period of time... period of time begins to run shall not be included, except as otherwise provided. Saturdays, Sundays, and...

40 CFR 209.12 - Time.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Time. 209.12 Section 209.12 Protection... Issued Under Section 11(d) of the Noise Control Act § 209.12 Time. (a) In computing any period of time... period of time begins to run shall not be included, except as otherwise provided. Saturdays, Sundays, and...

40 CFR 209.12 - Time.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Time. 209.12 Section 209.12 Protection... Issued Under Section 11(d) of the Noise Control Act § 209.12 Time. (a) In computing any period of time... period of time begins to run shall not be included, except as otherwise provided. Saturdays, Sundays, and...

40 CFR 209.12 - Time.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Time. 209.12 Section 209.12 Protection... Issued Under Section 11(d) of the Noise Control Act § 209.12 Time. (a) In computing any period of time... period of time begins to run shall not be included, except as otherwise provided. Saturdays, Sundays, and...

40 CFR 209.12 - Time.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Time. 209.12 Section 209.12 Protection... Issued Under Section 11(d) of the Noise Control Act § 209.12 Time. (a) In computing any period of time... period of time begins to run shall not be included, except as otherwise provided. Saturdays, Sundays, and...

26 CFR 1.141-12 - Remedial actions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Remedial actions. 1.141-12 Section 1.141-12...) INCOME TAXES (CONTINUED) Tax Exemption Requirements for State and Local Bonds § 1.141-12 Remedial actions. (a) Conditions to taking remedial action. An action that causes an issue to meet the private business...

26 CFR 1.141-12 - Remedial actions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Remedial actions. 1.141-12 Section 1.141-12...) INCOME TAXES (CONTINUED) Tax Exemption Requirements for State and Local Bonds § 1.141-12 Remedial actions. (a) Conditions to taking remedial action. An action that causes an issue to meet the private business...

Human resource processes and the role of the human resources function during mergers and acquisitions in the electricity industry

NASA Astrophysics Data System (ADS)

Dass, Ted K.

Mergers and acquisitions (M&A) have been a popular strategy for organizations to consolidate and grow for more than a century. However, research in this field indicates that M&A are more likely to fail than succeed, with failure rates estimated to be as high as 75%. People-related issues have been identified as important causes for the high failure rate, but these issues are largely neglected until after the deal is closed. One explanation for this neglect is the low involvement of human resource (HR) professionals and the HR function during the M&A process. The strategic HR management literature suggests that a larger role for HR professionals in the M&A process would enable organizations to identify potential problems early and devise appropriate solutions. However, empirical research from an HR perspective has been scarce in this area. This dissertation examines the role of the HR function and the HR processes followed in organizations during M&A. Employing a case-study research design, this study examines M&A undertaken by two large organizations in the electricity industry through the lens of a "process" perspective. Based on converging evidence, the case studies address three sets of related issues: (1) how do organizations undertake and manage M&A; (2) what is the extent of HR involvement in M&A and what role does it play in the M&A process; and (3) what factors explain HR involvement in the M&A process and, more generally, in the formulation of corporate goals and strategies. Results reveal the complexity of issues faced by organizations in undertaking M&A, the variety of roles played by HR professionals, and the importance of several key contextual factors---internal and external to the organization---that influence HR involvement in the M&A process. Further, several implications for practice and future research are explored.

30 CFR 795.12 - Applicant liability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR SMALL OPERATOR ASSISTANCE PERMANENT REGULATORY PROGRAM-SMALL OPERATOR ASSISTANCE PROGRAM § 795.12 Applicant... 12 months immediately following the date on which the operator is issued the surface coal mining and...

Phytoremediation of azoxystrobin and its degradation products in soil by P. major L. under cold and salinity stress.

PubMed

Romeh, Ahmed Ali Ali

2017-10-01

Azoxystrobin is a broad-spectrum, systemic and soil-applied fungicide used for crop protection against the four major classes of pathogenic fungi. The use of azoxystrobin use has induced water pollution and ecotoxicological effects upon aquatic organisms, long half-life in soils, as well as heath issues. Such issues may be solved by phytoremediation. Here, we tested the uptake and translocation of azoxystrobin and its degradation products by Plantago major, under cold stress and salt stress. The result demonstrated that azoxystrobin significantly accumulated in P. major roots under salinity conditions more than that in the P. major roots under cold conditions and natural condition within two days of experimental period. In P. major roots and leaves, the chromatograms of HPLC for azoxystrobin and metabolites under natural condition (control) and stressed samples (cold stress and salt stress) show different patterns of metabolism pathways reflecting changes in the degradation products. Azoxystrobin carboxylic acid (AZ-acid) formed by methyl ester hydrolysis was an important route in the roots and the leaves. AZ-pyOH and AZ-benzoic were detected in P. major roots under cold and salt stress, while did not detected in P. major roots under natural condition. In the leaves, AZ-pyOH and AZ-benzoic were detected in all treatments between 4 and 12days of exposure. Shoots of the stressed plants had greater H 2 O 2 and proline contents than was observed in the control plants. The level of 100mM NaCl treatment induced significantly higher peroxidase (POD) activity than the non-treated control group. Leaf Chlorophyll contents in the plants at 80 and 100mM NaCl were significantly reduced than was observed in the control plants. I concluded that P. major had a high potential to contribute to remediation of saline-soil contaminated with azoxystrobin. Copyright © 2016 Elsevier B.V. All rights reserved.

77 FR 20813 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

.... Comments Due: 5 p.m. ET 4/20/12. Docket Numbers: ER12-1397-000. Applicants: PJM Interconnection, L.L.C.... Comments Due: 5 p.m. ET 4/10/12. Take notice that the Commission received the following electric rate.../2012. Filed Date: 3/30/12. Accession Number: 20120330-5363. Comments Due: 5 p.m. ET 4/20/12. Docket...

78 FR 4446 - Exempt Chemical Preparations Under the Controlled Substances Act

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-22

... Laboratories Liquichek Immunoassay Plus Amber Vial: 10 mL; Box: 12/22/2011 Control Levels 1, 2, and 3. 12 vials. Bio-Rad Laboratories Liquichek Immunoassay Plus Amber Vial: 10 mL; Box: 12/22/2011 Control Trilevel. 12 vials. Bio-Rad Laboratories Liquichek Immunoassay Plus Amber Vial: 5 mL; Box: 3 12/22/2011 Control...

A new species of Caryospora Léger, 1904 (Apicomplexa: Eimeriidae) from the endangered Round Island boa Casarea dussumieri (Schlegel) (Serpentes: Bolyeridae) of Round Island, Mauritius: an endangered parasite?

PubMed

Daszak, Peter; Ball, Stanley J; Streicker, Daniel G; Jones, Carl G; Snow, Keith R

2011-02-01

A new species of Caryospora Léger, 1904 (Apicomplexa: Eimeriidae), C. durelli n. sp., is described from the endangered Round Island boa Casarea dussumieri (Schlegel) (Serpentes: Bolyeridae) from Round Island, Mauritius. Six of 11 hosts were infected. Oöcysts are spherical to subspherical, 19.2 × 18.2 (17.5-21 × 16-21) μm, n = 20, and have a shape index (mean length/mean width) of 1.05 (1.02-1.09). The bi-layered wall is composed of an outer layer of c.0.6 μm thick and an inner layer of c.0.4 μm thick. A micropyle, oöcyst residuum and polar granule are absent. Sporocysts are ellipsoidal, 14.7 × 11.0 (13-16 × 9.5-11.5) μm, n = 20, and have a shape index of 1.33. Both Stieda and substieda bodies are present. The sporocyst residuum measures c.12 × 4.5 μm, is surrounded by sporozoites and composed of numerous granules. Refractile bodies are present but not clearly visible. This is the first coccidian parasite reported from the family Bolyeridae and the first species of Caryospora durrelli [corrected] reported from the Mascarenes. Conservation issues concerning parasites of endangered host species are discussed.

5 CFR 2423.12 - Settlement of unfair labor practice charges after a Regional Director determination to issue a...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regional Director concludes effectuates the policies of the Federal Service Labor-Management Relations... charges after a Regional Director determination to issue a complaint but prior to issuance of a complaint... charges after a Regional Director determination to issue a complaint but prior to issuance of a complaint...

5 CFR 2423.12 - Settlement of unfair labor practice charges after a Regional Director determination to issue a...

Code of Federal Regulations, 2011 CFR

2011-01-01

... Regional Director concludes effectuates the policies of the Federal Service Labor-Management Relations... charges after a Regional Director determination to issue a complaint but prior to issuance of a complaint... charges after a Regional Director determination to issue a complaint but prior to issuance of a complaint...

The Best of CLEARING: Environmental Education in the Pacific Northwest. Volumes I-IV: Issues 1-80.

ERIC Educational Resources Information Center

1993

"Clearing" magazine is a bi-monthly environmental education resource and activity guide for K-12 teachers in the Pacific Northwest. Each of these four volumes is a compilation of outstanding articles and activities from past issues of "Clearing." Volume I (Issues 1-20) presents 47 articles organized into four sections:…

Emerging Issues in the Utilization of Weblogs in Higher Education Classrooms

ERIC Educational Resources Information Center

Ayao-ao, Shirley

2014-01-01

This paper examines the emerging issues in the utilization of weblogs in Philippine higher education and how these issues affect the performance of students. This study used a modified Delphi method. The Delphi panel consisted of 12 experts in the integration of technology, particularly blogs, in their teaching. The study yielded the following…

Positive Emotional Responses to Hybridised Writing about a Socio-Scientific Issue

ERIC Educational Resources Information Center

Tomas, Louisa; Ritchie, Stephen M.

2012-01-01

In order to understand better the role of affect in learning about socio-scientific issues (SSI), this study investigated Year 12 students' emotional arousal as they participated in an online writing-to-learn science project about the socio-scientific issue of biosecurity. Students wrote a series of hybridised scientific narratives, or BioStories,…

75 FR 33673 - Tart Cherries Grown in the States of Michigan, New York, Pennsylvania, Oregon, Utah, Washington...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... Recommended Decision issued on May 7, 2009 and published in the May 12, 2009, issue of the Federal Register (74 FR 22112), and a Secretary's Decision and Referendum Order issued on January 6, 2010, and... Decision and Opportunity to File Written Exceptions thereto. This Recommended Decision was published in the...

Understanding Key Education Issues: How We Got Here and Where We Go from Here

ERIC Educational Resources Information Center

Lynch, Matthew

2017-01-01

In this age of education innovation and reform, schools must evolve and react to current policy trends. This accessible book offers research-based insights into six key educational trends and issues that are impacting K-12 learning today: year-round schooling, assessments, educating minorities, anti-intellectualism, issues of social promotion and…

Vitamin B12 Production by Marine Bacteria in Organic Substrate Limited, Slow Growth Conditions

NASA Astrophysics Data System (ADS)

Villegas-Mendoza, J.; Cajal-Medrano, R.; Maske, H.

2016-02-01

The conditions and processes governing the B12 vitamin dissemination through planktonic organisms are little understood. It is generally assumed that bacteria produce B12 vitamin and the whole auxotrophic plankton community consumes it. We used natural marine bacteria communities and marine bacteria Dinoroseobacter shibae cultures, growing in substrate-limited continuous cultures at low specific growth rates [0.1 to 1 d-1] to measure intracellular and dissolved B12 production, bacterial and viral abundance, particulate organic carbon, and nitrogen, bacterial production, oxygen consumption, carbon dioxide production, ETS activity, and taxonomic composition. We find dissolved B12 vitamin at concentrations between 0 to 1.4 pM with no relation to growth or respiration rates. The intracellular B12 vitamin normalized to cell volume ranged between 1x10-2 to 4.6x10-2 pmol μm3 showing a significant relationship with growth rate [y=0.02(m)1.07; r2=0.78; p≤0.05; y=intracellular B12 production, pmol μm3 day-1; m=specific growth rate, day-1], and respiration rates [y=2.4ln(x)-2.66; r2=0.87; p≤0.05; x=CO2 production, μM day-1]. The vitamin B12 producing bacteria D. shibae, showed a dissolved B12 concentration between 0 and 1.8 pM, whereas intracellular B12 normalized to cell volume varied between 1.1x10-2 to 1.8x10-2 pmol μm-3, responding significantly to growth rate [y=0.01(m)0.56; r2=0.85; p≤0.05], and to respiration rates [y=3.01ln(x)-7.56, r2=0.97, p≤0.05; x=CO2 production, μM day-1]. The lack of correlation of dissolved B12 vitamin with the metabolic activity suggests that the dissolved B12 concentration depends on the interactions among vitamin B12 producers and consumers while the bacterial metabolism is regulating the intracellular production of B12 vitamin.

The Quarterly of the National Writing Project and the Center for the Study of Writing. Vol 11 No. 1-4.

ERIC Educational Resources Information Center

Sperling, Melanie, Ed.; Ylvisaker, Miriam, Ed.

1989-01-01

These four issues of The Quarterly of the National Writing Project cover the calendar year 1989. The January 1989 issue contains the following articles: (1) "The Unteachables" (J. Juska); (2) "Changing the Model" (M. Griffith and others); (3) "Literate Cultures: Multi-Voiced Classrooms" (M. Roemer); (4) "Despite…

Optically Pumped Mid-IR Vibrational Hydrogen Chloride Laser

DTIC Science & Technology

1998-01-01

p > HCl(v1,J1) (2) HCl(v1,J1) + h p > HCl(v",J") + 2h p (3) HCl(v1,J1) + hl > HCl(vf",Jf") + 2h...1,Jf 1) + HCl(vf ",Jf ") (7) where p and l refer to the pump and laser emission frequencies respectively. Equation (2) describes the optical...J,M) N (v1,JM) – 12(JM) 12J N (v,J) (10) .(v,J M,M) 1(v,J M,M) N (v,J) 12J 12(J M) N (v 1,J M) (11) For single quantum transitions, we

Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity.

PubMed

Scott, W K; Grubber, J M; Conneally, P M; Small, G W; Hulette, C M; Rosenberg, C K; Saunders, A M; Roses, A D; Haines, J L; Pericak-Vance, M A

2000-03-01

Apolipoprotein E (APOE) is the only confirmed susceptibility gene for late-onset Alzheimer disease (AD). In a recent genomic screen of 54 families with late-onset AD, we detected significant evidence for a second late-onset AD locus located on chromosome 12 between D12S373 and D12S390. Linkage to this region was strongest in 27 large families with at least one affected individual without an APOE-4 allele, suggesting that APOE and the chromosome 12 locus might have independent effects. We have since genotyped several additional markers across the region, to refine the linkage results. In analyzing these additional data, we have addressed the issue of heterogeneity in the data set by weighting results by clinical and neuropathologic features, sibship size, and APOE genotype. When considering all possible affected sib pairs (ASPs) per nuclear family, we obtained a peak maximum LOD score between D12S1057 and D12S1042. The magnitude and location of the maximum LOD score changed when different weighting schemes were used to control for the number of ASPs contributed by each nuclear family. Using the affected-relative-pair method implemented in GENEHUNTER-PLUS, we obtained a maximum LOD score between D12S398 and D12S1632, 25 cM from the original maximum LOD score. These results indicate that family size influences the location estimate for the chromosome 12 AD gene. The results of conditional linkage analysis by use of GENEHUNTER-PLUS indicated that evidence for linkage to chromosome 12 was stronger in families with affected individuals lacking an APOE-4 allele; much of this evidence came from families with affected individuals with neuropathologic diagnosis of dementia with Lewy bodies (DLB). Taken together, these results indicate that the chromosome 12 locus acts independently of APOE to increase the risk of late-onset familial AD and that it may be associated with the DLB variant of AD.

CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR.

PubMed

Circelli, Luisa; Sciammarella, Concetta; Guadagno, Elia; Tafuto, Salvatore; del Basso de Caro, Marialaura; Botti, Giovanni; Pezzullo, Luciano; Aria, Massimo; Ramundo, Valeria; Tatangelo, Fabiana; Losito, Nunzia Simona; Ieranò, Caterina; D'Alterio, Crescenzo; Izzo, Francesco; Ciliberto, Gennaro; Colao, Annamaria; Faggiano, Antongiulio; Scala, Stefania

2016-04-05

To evaluate the possible crosstalk between C-X-C chemokine receptor 4 (CXCR4)/C-X-C motif chemokine 12 (CXCL12)/C-X-C chemokine receptor 7 (CXCR7) axis with the mammalian target of rapamycin (mTOR) pathway in neuroendocrine tumors (NETs). Sixty-one human NETs were included into the study. CXCR4/CXCL12/CXCR7 axis and mTOR pathway were assessed by qRT-PCR and immunohistochemistry (IHC). The effect of mTOR inhibitor, RAD001, was evaluated on CXCR4 pathway through proliferation and p-Erk and p-AKT induction. CXCR4/CXCL12/CXCR7 axis and p-mTOR were found to be active and correlated with grading, Ki67 index and tumor stage. mTOR pathway activation significantly correlated with poor prognosis. In human NET cells, CXCL12 induced mTOR signalling while AMD3100 (CXCR4-antagonist) impaired it. The mTOR-antagonist, RAD001, impaired the CXCL12-dependent induction of CXCR4 downstream effectors. Combination of AMD3100 and RAD001 potentiate cell growth inhibition. CXCR4/CXCL12/CXCR7 axis is active in NETs and signals on mTOR. CXCR4 might be considered a prognostic factor in NETs. Combined treatment with AMD3100 and RAD001 may provide clinical benefits in NET patients with drug-resistant.

CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR

PubMed Central

Guadagno, Elia; Tafuto, Salvatore; del Basso de Caro, Marialaura; Botti, Giovanni; Pezzullo, Luciano; Aria, Massimo; Ramundo, Valeria; Tatangelo, Fabiana; Losito, Nunzia Simona; Ieranò, Caterina; D'Alterio, Crescenzo; Izzo, Francesco; Ciliberto, Gennaro; Colao, Annamaria; Faggiano, Antongiulio; Scala, Stefania

2016-01-01

Objective To evaluate the possible crosstalk between C-X-C chemokine receptor 4 (CXCR4)/C-X-C motif chemokine 12 (CXCL12)/C-X-C chemokine receptor 7 (CXCR7) axis with the mammalian target of rapamycin (mTOR) pathway in neuroendocrine tumors (NETs). Methods Sixty-one human NETs were included into the study. CXCR4/CXCL12/CXCR7 axis and mTOR pathway were assessed by qRT-PCR and immunohistochemistry (IHC). The effect of mTOR inhibitor, RAD001, was evaluated on CXCR4 pathway through proliferation and p-Erk and p-AKT induction. Results: CXCR4/CXCL12/CXCR7 axis and p-mTOR were found to be active and correlated with grading, Ki67 index and tumor stage. mTOR pathway activation significantly correlated with poor prognosis. In human NET cells, CXCL12 induced mTOR signalling while AMD3100 (CXCR4-antagonist) impaired it. The mTOR-antagonist, RAD001, impaired the CXCL12-dependent induction of CXCR4 downstream effectors. Combination of AMD3100 and RAD001 potentiate cell growth inhibition. Conclusions CXCR4/CXCL12/CXCR7 axis is active in NETs and signals on mTOR. CXCR4 might be considered a prognostic factor in NETs. Combined treatment with AMD3100 and RAD001 may provide clinical benefits in NET patients with drug-resistant. PMID:26934559

Temperature-activity relationships in Meligethes aeneus: implications for pest management

PubMed Central

Ferguson, Andrew W; Nevard, Lucy M; Clark, Suzanne J; Cook, Samantha M

2015-01-01

BACKGROUND Pollen beetle (Meligethes aeneus F.) management in oilseed rape (Brassica napus L.) has become an urgent issue in the light of insecticide resistance. Risk prediction advice has relied upon flight temperature thresholds, while risk assessment uses simple economic thresholds. However, there is variation in the reported temperature of migration, and economic thresholds vary widely across Europe, probably owing to climatic factors interacting with beetle activity and plant compensation for damage. The effect of temperature on flight, feeding and oviposition activity of M. aeneus was examined in controlled conditions. RESULTS Escape from a release vial was taken as evidence of flight and was supported by video observations. The propensity to fly followed a sigmoid temperature–response curve between 6 and 23 °C; the 10, 25 and 50% flight temperature thresholds were 12.0–12.5 °C, 13.6–14.2 °C and 15.5–16.2 °C, respectively. Thresholds were slightly higher in the second of two flight bioassays, suggesting an effect of beetle age. Strong positive relationships were found between temperature (6–20 °C) and the rates of feeding and oviposition on flower buds of oilseed rape. CONCLUSION These temperature relationships could be used to improve M. aeneus migration risk assessment, refine weather-based decision support systems and modulate damage thresholds according to rates of bud damage. © 2014 Society of Chemical Industry PMID:25052810

Corrosion barriers processed by Al electroplating and their resistance against flowing Pb-15.7Li

NASA Astrophysics Data System (ADS)

Krauss, Wolfgang; Konys, Jürgen; Wulf, Sven-Erik

2014-12-01

In the HCLL blanket design, ferritic-martensitic steels are in direct contact with the flowing liquid breeder Pb-15.7Li and have to withstand severe corrosion attack. Beyond corrosion, T-permeation from the breeder into the RAFM-steels is also an important issue and has to be reduced significantly. Earlier work showed that Al-based coatings can act as barriers for both, however, applied processes e.g. HDA or VPS exhibited strong drawbacks in the past. Meanwhile new industrial relevant coating processes, using electroplating technology are under development and called ECA (electrochemical aluminization) and ECX (electrochemical deposition from ionic liquids) process. In this study electrochemically Al-coated and heat-treated Eurofer samples were tested in PICOLO loop for exposure times up to 12,000 h (ECA) and 2000 h (first results ECX) respectively to determine corrosion properties in flowing Pb-15.7Li (550 °C, 0.1 m/s). Cross section analysis afterward corrosion testing proved the ability of thin Al-based barriers made by electrochemical techniques to protect the bare Eurofer from corrosion attack even at exposure times of 12,000 h. Determined radial corrosion rates lay between 10 and 20 μm/a. First results for ECX coated samples (2000 h) revealed more homogeneous corrosion behavior of the barrier layer itself compared to ECA.

8 CFR 499.1 - Prescribed forms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... shown or a subsequent edition date. Form No. Edition date Title and description M-288 12-30-87 United States History 1600-1987, Level II. M-289 12-31-87 United States History 1600-1987, Level I. M-290 01-01-90 U.S. Government Structure, Level II. M-291 12-31-87 U.S. Government Structure, Level I. M-302 03...

8 CFR 499.1 - Prescribed forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... shown or a subsequent edition date. Form No. Edition date Title and description M-288 12-30-87 United States History 1600-1987, Level II. M-289 12-31-87 United States History 1600-1987, Level I. M-290 01-01-90 U.S. Government Structure, Level II. M-291 12-31-87 U.S. Government Structure, Level I. M-302 03...

Role of light wavelengths in synchronization of circadian physiology in songbirds.

PubMed

Yadav, G; Malik, S; Rani, S; Kumar, V

2015-03-01

This study investigated whether at identical duration and equal energy level birds presented with short (450nm; blue, B) and long (640nm; red, R) light wavelengths would differentially interpret them and exhibit wavelength-dependent circadian behavioral and physiological responses, despite the difference in their breeding latitudes. Temperate migratory blackheaded buntings (Emberiza melanocephala) and subtropical non-migratory Indian weaverbirds (Ploceus philippinus) initially entrained to 12h light:12h darkness (12L:12D; L=0.33μM/m(2)/s, D=0μM/m(2)/s) in two groups of each, groups 1 and 2, were subjected to constant light (LL, 0.33μM/m(2)/s), which rendered them arrhythmic in the activity behavior. They were then exposed for about two weeks each to 12B:12R and 12R:12B (group 1) or 12R:12B and 12B:12R (group 2) at 0.33μM/m(2)/s light energy level. Blue and red light periods were interpreted as the day and night, respectively, with activity and no-activity in non-migratory weaverbirds or activity and intense activity (Zugunruhe, migratory night restlessness) in the migratory buntings. Consistent with this, plasma melatonin levels under B:R, not R:B, light cycle were low and high in blue and red light periods, respectively. A similar diurnal pattern was absent in the cortisol levels, however. These results show an important role of light wavelengths in synchronization of the circadian clock governed behavior and physiology to the photoperiodic environment, and suggest that photoperiodic timing might be a conserved physiological adaptation in many more birds, regardless of the difference in breeding latitudes, than has been generally envisaged. Copyright © 2014 Elsevier Inc. All rights reserved.

Integrated Interface Strategy toward Room Temperature Solid-State Lithium Batteries.

PubMed

Ju, Jiangwei; Wang, Yantao; Chen, Bingbing; Ma, Jun; Dong, Shanmu; Chai, Jingchao; Qu, Hongtao; Cui, Longfei; Wu, Xiuxiu; Cui, Guanglei

2018-04-25

Solid-state lithium batteries have drawn wide attention to address the safety issues of power batteries. However, the development of solid-state lithium batteries is substantially limited by the poor electrochemical performances originating from the rigid interface between solid electrodes and solid-state electrolytes. In this work, a composite of poly(vinyl carbonate) and Li 10 SnP 2 S 12 solid-state electrolyte is fabricated successfully via in situ polymerization to improve the rigid interface issues. The composite electrolyte presents a considerable room temperature conductivity of 0.2 mS cm -1 , an electrochemical window exceeding 4.5 V, and a Li + transport number of 0.6. It is demonstrated that solid-state lithium metal battery of LiFe 0.2 Mn 0.8 PO 4 (LFMP)/composite electrolyte/Li can deliver a high capacity of 130 mA h g -1 with considerable capacity retention of 88% and Coulombic efficiency of exceeding 99% after 140 cycles at the rate of 0.5 C at room temperature. The superior electrochemical performance can be ascribed to the good compatibility of the composite electrolyte with Li metal and the integrated compatible interface between solid electrodes and the composite electrolyte engineered by in situ polymerization, which leads to a significant interfacial impedance decrease from 1292 to 213 Ω cm 2 in solid-state Li-Li symmetrical cells. This work provides vital reference for improving the interface compatibility for room temperature solid-state lithium batteries.

Development and fabrication of the vacuum systems for an elliptically polarized undulator at Taiwan Photon Source

NASA Astrophysics Data System (ADS)

Chang, Chin-Chun; Chan, Che-Kai; Wu, Ling-Hui; Shueh, Chin; Shen, I.-Ching; Cheng, Chia-Mu; Yang, I.-Chen

2017-05-01

Three sets of a vacuum system were developed and fabricated for elliptically polarized undulators (EPU) of a 3-GeV synchrotron facility. These chambers were shaped with low roughness extrusion and oil-free machining; the design combines aluminium and stainless steel. The use of a bimetallic material to connect the EPU to the vacuum system achieves the vacuum sealing and to resolve the leakage issue due to bake process induced thermal expansion difference. The interior of the EPU chamber consists of a non-evaporable-getter strip pump in a narrow space to absorb photon-stimulated desorption and to provide a RF bridge design to decrease impedance effect in the two ends of EPU chamber. To fabricate these chambers and to evaluate the related performance, we performed a computer simulation to optimize the structure. During the machining and welding, the least deformation was achieved, less than 0.1 mm near 4 m. In the installation, the linear slider can provide a stable and precision moved along parallel the electron beam direction smoothly for the EPU chamber to decrease the twist issue during baking process. The pressure of the EPU chamber attained less than 2×10-8 Pa through baking. These vacuum systems of the EPU magnet have been installed in the electron storage ring of Taiwan Photon Source in 2015 May and have normally operated at 300 mA continuously since, and to keep beam life time achieved over than 12 h.

KSC-2011-3558

NASA Image and Video Library

2011-05-15

CAPE CANAVERAL, Fla. - Water bags, called red water sausages, are revealed on Launch Pad 39A at NASA's Kennedy Space Center in Florida following the move of the rotating service structure (RSS). RSS "rollback," as it's called, began at 11:44 a.m. EDT on May 15 and was completed at 12:24 p.m. The bags will dampen the wave of sound energy that is reflected back up toward space shuttle Endeavour when the solid rocket boosters ignite during launch. They suppress the powerful pulse of pressure to prevent dangerous stress on the wings of the shuttle. STS-134 will deliver the Alpha Magnetic Spectrometer-2 (AMS), Express Logistics Carrier-3, a high-pressure gas tank and additional spare parts for the Dextre robotic helper to the International Space Station. May 16 at 8:56 a.m. will be the second launch attempt for Endeavour. The first attempt on April 29 was scrubbed because of an issue associated with a faulty power distribution box called the aft load control assembly-2 (ALCA-2). STS-134 will be the final spaceflight for Endeavour. For more information visit, www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts134/index.html. Photo credit: NASA/Jack Pfaller

KSC-2011-3557

NASA Image and Video Library

2011-05-15

CAPE CANAVERAL, Fla. - Water bags, called red water sausages, are revealed on Launch Pad 39A at NASA's Kennedy Space Center in Florida following the move of the rotating service structure (RSS). RSS "rollback," as it's called, began at 11:44 a.m. EDT on May 15 and was completed at 12:24 p.m. The bags will dampen the wave of sound energy that is reflected back up toward space shuttle Endeavour when the solid rocket boosters ignite during launch. They suppress the powerful pulse of pressure to prevent dangerous stress on the wings of the shuttle. STS-134 will deliver the Alpha Magnetic Spectrometer-2 (AMS), Express Logistics Carrier-3, a high-pressure gas tank and additional spare parts for the Dextre robotic helper to the International Space Station. May 16 at 8:56 a.m. will be the second launch attempt for Endeavour. The first attempt on April 29 was scrubbed because of an issue associated with a faulty power distribution box called the aft load control assembly-2 (ALCA-2). STS-134 will be the final spaceflight for Endeavour. For more information visit, www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts134/index.html. Photo credit: NASA/Jack Pfaller

Self-Powered Wireless Smart Sensor Node Enabled by an Ultrastable, Highly Efficient, and Superhydrophobic-Surface-Based Triboelectric Nanogenerator.

PubMed

Zhao, Kun; Wang, Zhong Lin; Yang, Ya

2016-09-27

Wireless sensor networks will be responsible for a majority of the fast growth in intelligent systems in the next decade. However, most of the wireless smart sensor nodes require an external power source such as a Li-ion battery, where the labor cost and environmental waste issues of replacing batteries have largely limited the practical applications. Instead of using a Li-ion battery, we report an ultrastable, highly efficient, and superhydrophobic-surface-based triboelectric nanogenerator (TENG) to scavenge wind energy for sustainably powering a wireless smart temperature sensor node. There is no decrease in the output voltage and current of the TENG after continuous working for about 14 h at a wind speed of 12 m/s. Through a power management circuit, the TENG can deliver a constant output voltage of 3.3 V and a pulsed output current of about 100 mA to achieve highly efficient energy storage in a capacitor. A wireless smart temperature sensor node can be sustainably powered by the TENG for sending the real-time temperature data to an iPhone under a working distance of 26 m, demonstrating the feasibility of the self-powered wireless smart sensor networks.

The Age of the Inner Halo Globular Cluster NGC 6652

NASA Technical Reports Server (NTRS)

Chaboyer, Brian; Sarajedini, Ata; Armandroff, Taft E.

2000-01-01

Hubble Space Telescope (HST) (V,I) photometry has been obtained for the inner halo globular cluster NGC 6652. The photometry reaches approximately 4 mag below the turn-off and includes a well populated horizontal branch (HB). This cluster is located close to the Galactic center at RGC approximately equal to 2.0 kpc with a reddening of E(V-I) = 0.15 +/- 0.02 and has a metallicity of [Fe/H] approximately equal to -0.85. Based upon DELTA V (sup SGB) (sub HB), NGC 6652 is 11.7 plus or minus 1.6 Gyr old. Using A HB precise differential ages for 47 Tuc (a thick disk globular), M107 and NGC 1851 (both halo clusters) were obtained. NGC 6652 appears to be the same age as 47 Tuc and NGC 1851 (within +/- 1.2 Gyr), while there is a slight suggestion that M107 is older than NGC 6652 by 2.3 +/- 1.5 Gyr. As this is a less than 2 sigma result, this issue needs to be investigated further before a definitive statement regarding the relative age of M107 and NGC 6652 may be made.

22 CFR 232.12 - Prosecution of claims.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Prosecution of claims. 232.12 Section 232.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REPUBLIC OF TUNISIA LOAN GUARANTEES ISSUED UNDER THE DEPARTMENT OF STATE, FOREIGN OPERATIONS, AND RELATED PROGRAMS APPROPRIATIONS ACT, 2012, DIV. I...

22 CFR 232.12 - Prosecution of claims.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Prosecution of claims. 232.12 Section 232.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT REPUBLIC OF TUNISIA LOAN GUARANTEES ISSUED UNDER THE DEPARTMENT OF STATE, FOREIGN OPERATIONS, AND RELATED PROGRAMS APPROPRIATIONS ACT, 2012, DIV. I...

Thermomechanical Cracking in Layered Media from Moving Friction Load,

DTIC Science & Technology

1984-07-01

Dimensionless Temperature The materials of the surface layer and the substrate are the same as Figure 1. D = Hi = 2, x = 0.01 in 61 13. Dimensionless...J 2 (j 2 M2 )] )(60) and 01) (4 ) / 2 2 2 , ")VI’ - [(i - M2 /J 2) + (U - M2 2/ ,(1) + ( - M2/12 )(I - M2/j2)V(1 ) = 0 ( 61 ) 18 .. .. mm...ii - -iii - -ml m . . . . . . . .-... -- Equation ( 61 ) has a characteristic equation x4 _ (I - M2/J2) + (1 - M2/12 )]x2 +(1 - M2/12 )(1 - M2

Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells.

PubMed

Liao, Qiuxia; Zhang, Rui; Wang, Xiaoyu; Nian, Weiwei; Ke, Lulu; Ouyang, Wei; Zhang, Zigui

2017-09-01

This study investigated the effects of fluoride exposure on the mRNA expression of Cav1.2 calcium signaling pathway and apoptosis regulatory molecules in PC12 cells. The viability of PC12 cell receiving high fluoride (5.0mM) and low fluoride (0.5mM) alone or fluoride combined with L-type calcium channel (LTCC) agonist/inhibitor (5umol/L FPL6417/2umol/L nifedipine) was detected using cell counting kit-8 at different time points (2, 4, 6, 8, 12, 10, and 24h). Changes in the cell configuration were observed after exposing the cells to fluoride for 24h. The expression levels of molecules related to the LTCC were examined, particularly, Cav1.2, c-fos, CAMK II, Bax, and Bcl-2. Fluoride poisoning induced severe cell injuries, such as decreased PC12 cell activity, enhanced cell apoptosis, high c-fos, CAMKII, and Bax mRNA expression levels. Bcl-2 expression level was also reduced. Meanwhile, high fluoride, high fluoride with FPL64176, and low fluoride with FPL64176 enhanced the Cav1.2 expression level. In contrast, low fluoride, high fluoride with nifedipine, and low fluoride with nifedipine reduced the Cav1.2 expression level. Thus, Cav1.2 may be an important molecular target for the fluorosis treatment, and the LTCC inhibitor nifedipine may be an effective drug for fluorosis. Copyright © 2017 Elsevier B.V. All rights reserved.

Anthocyanins from roselle extract arrest cell cycle G2/M phase transition via ATM/Chk pathway in p53-deficient leukemia HL-60 cells.

PubMed

Tsai, Tsung-Chang; Huang, Hui-Pei; Chang, Kai-Ting; Wang, Chau-Jong; Chang, Yun-Ching

2017-04-01

Cell cycle regulation is an important issue in cancer therapy. Delphinidin and cyanidin are two major anthocyanins of the roselle plant (Hibiscus sabdariffa). In the present study, we investigated the effect of Hibiscus anthocyanins (HAs) on cell cycle arrest in human leukemia cell line HL-60 and the analyzed the underlying molecular mechanisms. HAs extracted from roselle calyces (purity 90%) markedly induced G2/M arrest evaluated with flow cytometry analysis. Western blot analyses revealed that HAs (0.1-0.7 mg mL -1 ) induced G2/M arrest via increasing Tyr15 phosphorylation of Cdc2, and inducing Cdk inhibitors p27 and p21. HAs also induced phosphorylation of upstream signals related to G2/M arrest such as phosphorylation of Cdc25C tyrosine phosphatase at Ser216, increasing the binding of pCdc25C with 14-3-3 protein. HAs-induced phosphorylation of Cdc25C could be activated by ATM checkpoint kinases, Chk1, and Chk2. We first time confirmed that ATM-Chk1/2-Cdc25C pathway as a critical mechanism for G2/M arrest in HAs-induced leukemia cell cycle arrest, indicating that this compound could be a promising anticancer candidate or chemopreventive agents for further investigation. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1290-1304, 2017. © 2016 Wiley Periodicals, Inc.

Editor's highlight: Evaluation of a Microelectrode Array-based ...

EPA Pesticide Factsheets

Thousands of compounds in the environment have not been characterized for developmental neurotoxicity (DNT) hazard. To address this issue, methods to screen compounds rapidly for DNT hazard evaluation are necessary and are being developed for key neurodevelopmental processes. In order to develop an assay for network formation, the current study evaluated effects of a training set of chemicals on network ontogeny by measuring spontaneous electrical activity in neural networks grown on microelectrode arrays (MEA). Rat (0-24 h old) primary cortical cells were plated in 48 well MEA plates and exposed to six compounds: acetaminophen, bisindolylmaleimide-1 (Bis-1), domoic acid, mevastatin, sodium orthovanadate, and loperamide for a period of 12 days. Spontaneous network activity was recorded on days 2, 5, 7, 9, and 12 and viability was assessed using the Cell Titer Blue® assay on day 12. Network activity (e.g. mean firing rate (MFR), burst rate (BR), etc), increased between days 5 and 12. Random Forest analysis indicated that across all compounds and times, temporal correlation of firing patterns (r), MFR, BR, #of active electrodes and % of spikes in a burst were the most influential parameters in separating control from treated wells. All compounds except acetaminophen (≤ 30 µM) caused concentration-related effects on one or more of these parameters. Domoic acid and sodium orthovanadate altered several of these parameters in the absence of cytotoxicity. Although

75 FR 11998 - Open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Issue Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... Earned Income Tax Credit Issue Committee AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of Meeting. SUMMARY: An open meeting of the Taxpayer Advocacy Panel Earned Income Tax Credit Issue... Advocacy Panel Earned Income Tax Credit Issue Committee will be held Tuesday, April 20, 2010 from 8 a.m. to...

Idaho K-12 & School Choice Survey: What Do Voters Say about K-12 Education. Polling Paper No. 5

ERIC Educational Resources Information Center

DiPerna, Paul

2012-01-01

The "Idaho K-12 & School Choice Survey" project, commissioned by The Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Idaho registered voters' familiarity and views on a range of K-12 education issues and school choice reforms. We report response "levels" and…

46 CFR 12.40-11 - Citizenship and identity.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Citizenship and identity. 12.40-11 Section 12.40-11... Passenger Vessels § 12.40-11 Citizenship and identity. (a) In lieu of the requirements of § 10.221 of this... and identity requirements of this subpart, an applicant must present an unexpired passport issued by...

46 CFR 12.40-11 - Citizenship and identity.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Citizenship and identity. 12.40-11 Section 12.40-11... Passenger Vessels § 12.40-11 Citizenship and identity. (a) In lieu of the requirements of § 10.221 of this... and identity requirements of this subpart, an applicant must present an unexpired passport issued by...

46 CFR 12.40-11 - Citizenship and identity.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Citizenship and identity. 12.40-11 Section 12.40-11... Passenger Vessels § 12.40-11 Citizenship and identity. (a) In lieu of the requirements of § 10.221 of this... and identity requirements of this subpart, an applicant must present an unexpired passport issued by...

46 CFR 12.40-11 - Citizenship and identity.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Citizenship and identity. 12.40-11 Section 12.40-11... Passenger Vessels § 12.40-11 Citizenship and identity. (a) In lieu of the requirements of § 10.221 of this... and identity requirements of this subpart, an applicant must present an unexpired passport issued by...

Alaska K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper No. 3

ERIC Educational Resources Information Center

DiPerna, Paul

2011-01-01

The "Alaska K-12 & School Choice Survey" project, commissioned by The Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures Alaska registered voters' familiarity and views on a range of K-12 education issues and school choice reforms. The author and his colleagues report response…

12 CFR 3.601 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... which has become final as defined in 12 U.S.C. 1818(k). Violation of a directive may result in... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Purpose and scope. 3.601 Section 3.601 Banks... to issue a directive under 12 U.S.C. 3907(b)(2) or 12 U.S.C. 1464(s), as appropriate. A directive is...

Theoretical investigation of M@Pb122- and M@Sn122- Zintl clusters (M = Lrn+, Lun+, La3+, Ac3+ and n = 0, 1, 2, 3).

PubMed

Joshi, Meenakshi; Chandrasekar, Aditi; Ghanty, Tapan K

2018-06-06

The positions of lawrencium (Lr), lutetium (Lu), actinium (Ac) and lanthanum (La) in the periodic table have been a controversial topic for quite some time. According to studies carried out by different groups with their justifications, these elements may potentially be placed in the d-block, p-block or all four in a 15 element f-block. The present work looks into this issue from a new perspective, which involves encapsulation of these four elements into Zintl ion clusters, Pb122- and Sn122-, followed by the determination of the structural, thermodynamic and electronic properties of these endohedral M@Pb122- and M@Sn122- clusters (M = Lrn+, Lun+ with n = 0, 1, 2, 3) using first principles based density functional theory (DFT). These parameters are compared with similar clusters encapsulated La3+ and Ac3+ ions in order to seek out similarities and differences to draw conclusions about their placement in the periodic table. For the first time the structural, energetic, and electronic properties of these metal atom/ion encapsulated Pb122- and Sn122- clusters have been investigated thoroughly. Structural parameters such as bond distances, geometry and symmetry, electronic properties viz. the density of states, the molecular orbital ordering, the electron localization function, bond critical point properties and charge distributions have been analyzed. Additionally, the thermodynamic property of the binding energy during the encapsulation process has also been calculated. All M@Pb12+ and M@Sn12+ (M = Lr and Lu) clusters form stable 18 bonding electron magic number systems with shell closing. They show negative values of binding energy and relatively large HOMO-LUMO energy gaps indicating the stability of such clusters. All the calculated parameters for Lr encapsulated clusters closely match with the corresponding calculated parameters of Lu encapsulated clusters, confirming the similarity between Lr and Lu metal atoms in various oxidation states, though their atomic ground state valence electronic configurations are different. The effect of spin orbit coupling has also been investigated using the ZORA approach. It is interesting to discover that La and Ac showed striking similarities to Lr and Lu with respect to all the properties investigated and have formed a stable 18-electron system.

Genetic map of the spinocerebellar ataxia type 2 (SCA2) region on chromosome 12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nechiporuk, A.; Frederick, T.; Pulst, S.M.

1994-09-01

The autosomal dominant ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative diseases characterized by progressive ataxia. At least four gene loci have been identified: SCA1 on chromosome (CHR) 6, SCA2 on CHR12, Machado-Joseph disease on CHR14, and SCA families that are not linked to any of the above loci. In addition, the gene causing dentato-rubro-pallido-luysian atrophy has been identified as an expanded CAG repeat on CHR 12p. As a necessary step in identifying the gene for SCA2, we now identified closer flanking markers. To do this we ordered microsatellite markers in the now identified closer flanking markers.more » To do this we ordered microsatellite markers in the region and then determined pairwise and multipoint lod scores between the markers and SCA2 in three large pedigrees with SCA. The following order was established with odds > 1,000:1 using six non-SCA pedigrees: D12S101-7.1cM-D12S58-0cM-IGF1-3.6cM-D12S78-1.4cM-D12S317-3.7cM-D12S84-0cM-D12S105-7.2cM-D12S79-7.0cM-PLA2. Using this ordered set of markers we examined linkage to SCA2 in three pedigrees of Italian, Austrian and French-Canadian descent. Pairwise linkage analysis resulted in significant positive lod scores for all markers. The highest pairwise lod score was obtained with D12S84/D12S105 (Z{sub max}=7.98, theta{sub max}=0.05). To further define the location of SCA2, we performed multipoint linkage analysis using the genetic map established above. The highest location score was obtained between D12S317 and D12S84/D12S105. A location of SCA2 between these loci was favored with odds > 100:1. These data likely narrow the SCA2 candidate region to approximately 3.7 cM. The relatively large large number of markers tightly linked to SCA2 will facilitate the assignment of additional SCA pedigrees to CHR12, and will help in the presymptomatic diagnosis of individuals in families with proven linkage to CHR12.« less

Sustained Immunogenicity of 2-dose Human Papillomavirus 16/18 AS04-adjuvanted Vaccine Schedules in Girls Aged 9–14 Years: A Randomized Trial

PubMed Central

Puthanakit, Thanyawee; Cheng-Hsun, Chiu; Ren-Bin, Tang; Schwarz, Tino; Pellegrino, Angelo; Esposito, Susanna; Frenette, Louise; McNeil, Shelly; Durando, Paolo; Rheault, Paul; Giaquinto, Carlo; Horn, Michael; Petry, Karl Ulrich; Peters, Klaus; Azhar, Toma; Hillemanns, Peter; De Simoni, Stephanie; Friel, Damien; Pemmaraju, Suryakiran; Hezareh, Marjan; Thomas, Florence; Descamps, Dominique; Folschweiller, Nicolas; Struyf, Frank

2017-01-01

Abstract Background. We previously reported the noninferiority 1 month after the last dose of 2-dose human papillomavirus 16/18 AS04-adjuvanted (AS04-HPV-16/18) vaccine schedules at months 0 and 6 (2D_M0,6) and months 0 and 12 (2D_M0,12) in girls aged 9–14 years compared with a 3-dose schedule at months 0, 1, and 6 (3D_M0,1,6) in women aged 15–25 years. Here, we report the results at study end (month 36 [M36]). Methods. Girls were randomized 1:1 and received 2 vaccine doses either 6 months (2D_M0,6) or 12 months apart (2D_M0,12); women received 3 doses at months 0, 1, and 6 (3D_M0,1,6). Endpoints included noninferiority of HPV-16/18 antibodies for 2D_M0,6 versus 3D_M0,1,6; 2D_M0,12 versus 3D_M0,1,6; and 2D_M0,12 versus 2D_M0,6; and assessment of neutralizing antibodies, T cells, B cells, and safety. Results. At M36, the 2D_M0,6 and 2D_M0,12 schedules remained noninferior to the 3D_M0,1,6 schedule in terms of seroconversion rates and 3D/2D geometric mean titers for anti-HPV-16 and anti-HPV-18. All schedules elicited sustained immune responses up to M36. Conclusions. Both 2-dose schedules in young girls remained noninferior to the 3-dose schedule in women up to study conclusion at M36. The AS04-HPV-16/18 vaccine administered as a 2-dose schedule was immunogenic and well tolerated in young girls. PMID:28591778

Violence.

ERIC Educational Resources Information Center

Council of Europe Forum, 1985

1985-01-01

Highlighting the issue of violence, this Forum issue contains 12 essays. Titles and authors are: "Passivity in the Face of Violence" (Henri Laborit); "Democratisation without Violence?" (Friedrich Hacker); "Ritualised Violence in Sport" (Christian Bromberger); "Violence in Prisons" (Luige Daga); "Racial Aggression" (Geoffrey Bindman); "Violence in…

The EPRDATA Format: A Dialogue

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, III, Henry Grady

2015-08-18

Recently the Los Alamos Nuclear Data Team has communicated certain issues of concern in relation to the new electron/photon/relaxation ACE data format as released in the eprdata12 library. In this document those issues are parsed, analyzed, and answered.

12 CFR 220.123 - Partial delayed issue contracts covering nonconvertible bonds.

Code of Federal Regulations, 2010 CFR

2010-01-01

... certificate can be delivered by the transfer agent. The Board held that mutual fund shares must be regarded as.... (ibid.) The issuance of debt securities subject to delayed issue contracts, by contrast with that of...

Slope monitoring by using 2-D resistivity method at Sungai Batu, Pulau Pinang, Malaysia

NASA Astrophysics Data System (ADS)

Azman, Muhamad Iqbal Mubarak Faharul; Yusof, Azim Hilmy Mohd; Ismail, Nur Azwin; Ismail, Noer El Hidayah

2017-07-01

Slope is a dynamic system of geo-environmental phenomena that related to the movement of the soil and rock masses. In Pulau Pinang, the occurrence of slope related phenomena such as landslide and rock fall has become a huge issue especially during rainy season as the government would have to invest more for the people safety. 2-D resistivity method is one of the geophysical methods that can be applied to overcome this issue thus prepare countermeasure actions. Monitoring is one of the common acquisition technique that has been used in solving such issue. This technique was applied to identify and monitor changes at the suspected area and thus, countermeasure steps can be taken accordingly and not blindfolded. Starting from August until November 2016, a 200 m survey line of 2-D resistivity survey had been conducted monthly at Sungai Batu, Pulau Pinang slope for monitoring purpose. Three resistivity ranges were able to detect within the subsurface. Resistivity value of 250 - 400 Ωm indicated the low resistivity value and interpreted as the weak zone located at distance of 90 - 120 m with depth of 10 m. Intermediate resistivity value was interpreted as weathered granite zone with resistivity value of 400 - 1500 Ωm was found at almost along survey line. High resistivity value was > 5000 Ωm and interpreted as granitic bedrock located at depth of > 20 m. Aside from weathered granite zone and weak zone, a fracture was found develop over time at distance of 130 - 140 m. The features found have the potential to be the cause for slope failure phenomena to occur. As a conclusion, monitoring slope using 2-D resistivity method is a success and indeed helpful in overcome landslide and rock fall issue as a pre-countermeasure action.

Postsecondary Education Opportunity. The Mortenson Report on Public Policy Analysis of Opportunity for Postsecondary Education, 1995.

ERIC Educational Resources Information Center

Mortenson, Thomas G., Ed.

1995-01-01

This document is a collection of 12 issues of a monthly publication on public policy and postsecondary education opportunity. Each issue contains one or two main articles providing an analysis of research on trends in postsecondary education. The major articles in these issues are: (1) "The Challenge of Educational Opportunity in Public…

The Media and Children's Issues. Final Report on the Children's Express Symposium III (New York, New York, June 11-12, 1990).

ERIC Educational Resources Information Center

Children's Express Foundation, Inc., New York, NY.

This document is a report of the Children's Express Symposium III, a forum for journalists on children's issues. Included in the report are the comments of news media executives, journalists, broadcasters, experts on children's issues, directors of children's programs, and young people affected by the policies and practices discussed. Opening…

76 FR 6323 - Airworthiness Directives; General Electric Company CF6-45 and CF6-50 Series Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... reports received of additional causes of HPT rotor imbalance not addressed in AD 2010-12-10, and two additional LPT rotor stage 3 disk events. We are issuing this AD to prevent critical life-limited rotating... issued. We issued those ADs to prevent critical life-limited rotating engine part failure, which could...

76 FR 59391 - Notice of Availability of Government-Owned Inventions; Available for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... Issued 4/12/2011//U.S. Patent No. 7,926,275: Closed Brayton Cycle Direct Contact Reactor/Storage Tank... With Precursor Bubble Issued 4/19/2011//U.S. Patent No. 7,929,375: Method and Apparatus for Improved...: Hydrogen Generator Apparatus for an Underwater Vehicle Issued 5/10/2011//U.S. Patent No. 7,940,602...

26 CFR 1.163-4 - Deduction for original issue discount on certain obligations issued after May 27, 1969.

Code of Federal Regulations, 2010 CFR

2010-04-01

... be includible in the gross income of such taxpayer for such taxable year. (b) Examples. The rules in... Board of Governors of the Federal Reserve. See 12 CFR § 217.4(d). The stated redemption price at... any amount of original issue discount deducted prior to repurchase, or minus any amount of premium...

College and Career Readiness: K-12 and Higher Education Collaborating for Student Success. coNCepts. Issue 5, Jan 2014

ERIC Educational Resources Information Center

Harris, Buddy

2014-01-01

"coNCepts" is a state-specific policy primer of The Hunt Institute. Each issue focuses on a critical topic in education policy, highlights key research for North Carolina policymakers, and prompts discussion of solutions. This issue begins by describing North Carolina's economy as having experienced a remarkable transformation during the…

Unusual Phase Diagram of CeOs 4Sb 12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ho, P. -C.; Goddard, P. A.; Maple, M. B.

2017-03-01

Filled skutterudite compounds, with the formula MT 4X 12, where M is an alkali metal, alkaline-earth, lanthanide, or actinide, T is Fe, Ru, or Os, and X is P, As, or Sb, display a wide variety of interesting phenomena caused by strong electron correlations [1]. Among these, the three compounds CeOs 4Sb 12, PrOs 4Sb 12, and NdOs 4Sb 12, formed by employing Periodic Table neighbors for M, span the range from an antiferromagnetic (AFM) semimetal (M = Ce) via a 1.85 K unconventional (quadrupolar-fluctuation mediated) superconductor (M = Pr) to a 1 K ferromagnet (FM; M = Nd). Inmore » the course of an extended study of these compounds, we uncovered an unusual phase diagram for CeOs 4Sb 12.« less

22 CFR 231.12 - Prosecution of claims.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Prosecution of claims. 231.12 Section 231.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

22 CFR 231.12 - Prosecution of claims.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Prosecution of claims. 231.12 Section 231.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

22 CFR 233.12 - Prosecution of claims.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Prosecution of claims. 233.12 Section 233.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT HASHEMITE KINGDOM OF JORDAN LOAN GUARANTEES ISSUED UNDER THE FURTHER CONTINUING APPROPRIATIONS ACT, 2013, DIV. F, PUB. L. 113-6-STANDARD TERMS AND...

22 CFR 231.12 - Prosecution of claims.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Prosecution of claims. 231.12 Section 231.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

22 CFR 231.12 - Prosecution of claims.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Prosecution of claims. 231.12 Section 231.12 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND...

Development of mRuby2-Transfected C3H10T1/2 Fibroblasts for Musculoskeletal Tissue Engineering

PubMed Central

Yang, Yunzhi Peter

2015-01-01

Mouse C3H10T1/2 fibroblasts are multipotent, mesenchymal stem cell (MSC)-like progenitor cells that are widely used in musculoskeletal research. In this study, we have established a clonal population of C3H10T1/2 cells stably-transfected with mRuby2, an orange-red fluorescence reporter gene. Flow cytometry analysis and fluorescence imaging confirmed successful transfection of these cells. Cell counting studies showed that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells proliferated at similar rates. Adipogenic differentiation experiments demonstrated that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells stained positive for Oil Red O and showed increased expression of adipogenic genes including adiponectin and lipoprotein lipase. Chondrogenic differentiation experiments demonstrated that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells stained positive for Alcian Blue and showed increased expression of chondrogenic genes including aggrecan. Osteogenic differentiation experiments demonstrated that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells stained positive for alkaline phosphatase (ALP) as well as Alizarin Red and showed increased expression of osteogenic genes including alp, ocn and osf-1. When seeded on calcium phosphate-based ceramic scaffolds, mRuby2-transfected C3H10T1/2 cells maintained even fluorescence labeling and osteogenic differentiation. In summary, mRuby2-transfected C3H10T1/2 cells exhibit mRuby2 fluorescence and showed little-to-no difference in terms of cell proliferation and differentiation as untransfected C3H10T1/2 cells. These cells will be available from American Type Culture Collection (ATCC; CRL-3268™) and may be a valuable tool for preclinical studies. PMID:26407291

Development of mRuby2-Transfected C3H10T1/2 Fibroblasts for Musculoskeletal Tissue Engineering.

PubMed

Ker, Dai Fei Elmer; Sharma, Rashmi; Wang, Evelyna Tsi Hsin; Yang, Yunzhi Peter

2015-01-01

Mouse C3H10T1/2 fibroblasts are multipotent, mesenchymal stem cell (MSC)-like progenitor cells that are widely used in musculoskeletal research. In this study, we have established a clonal population of C3H10T1/2 cells stably-transfected with mRuby2, an orange-red fluorescence reporter gene. Flow cytometry analysis and fluorescence imaging confirmed successful transfection of these cells. Cell counting studies showed that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells proliferated at similar rates. Adipogenic differentiation experiments demonstrated that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells stained positive for Oil Red O and showed increased expression of adipogenic genes including adiponectin and lipoprotein lipase. Chondrogenic differentiation experiments demonstrated that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells stained positive for Alcian Blue and showed increased expression of chondrogenic genes including aggrecan. Osteogenic differentiation experiments demonstrated that untransfected C3H10T1/2 cells and mRuby2-transfected C3H10T1/2 cells stained positive for alkaline phosphatase (ALP) as well as Alizarin Red and showed increased expression of osteogenic genes including alp, ocn and osf-1. When seeded on calcium phosphate-based ceramic scaffolds, mRuby2-transfected C3H10T1/2 cells maintained even fluorescence labeling and osteogenic differentiation. In summary, mRuby2-transfected C3H10T1/2 cells exhibit mRuby2 fluorescence and showed little-to-no difference in terms of cell proliferation and differentiation as untransfected C3H10T1/2 cells. These cells will be available from American Type Culture Collection (ATCC; CRL-3268™) and may be a valuable tool for preclinical studies.

Gene expression and pharmacology of nematode NLP-12 neuropeptides.

PubMed

McVeigh, Paul; Leech, Suzie; Marks, Nikki J; Geary, Timothy G; Maule, Aaron G

2006-05-31

This study examines the biology of NLP-12 neuropeptides in Caenorhabditis elegans, and in the parasitic nematodes Ascaris suum and Trichostrongylus colubriformis. DYRPLQFamide (1 nM-10 microM; n > or =6) produced contraction of innervated dorsal and ventral Ascaris body wall muscle preparations (10 microM, 6.8+/-1.9 g; 1 microM, 4.6+/-1.8 g; 0.1 microM, 4.1+/-2.0 g; 10 nM, 3.8+/-2.0 g; n > or =6), and also caused a qualitatively similar, but quantitatively lower contractile response (10 microM, 4.0+/-1.5 g, n=6) on denervated muscle strips. Ovijector muscle displayed no measurable response (10 microM, n=5). nlp-12 cDNAs were characterised from A. suum (As-nlp-12) and T. colubriformis (Tc-nlp-12), both of which show sequence similarity to C. elegans nlp-12, in that they encode multiple copies of -LQFamide peptides. In C. elegans, reverse transcriptase (RT)-PCR analysis showed that nlp-12 was transcribed throughout the life cycle, suggesting that DYRPLQFamide plays a constitutive role in the nervous system of this nematode. Transcription was also identified in both L3 and adult stages of T. colubriformis, in which Tc-nlp-12 is expressed in a single tail neurone. Conversely, As-nlp-12 is expressed in both head and tail tissue of adult female A. suum, suggesting species-specific differences in the transcription pattern of this gene.

Serum hCG-β levels of postovulatory day 12 and 14 with the sequential application of hCG-β fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle.

PubMed

Sung, Nayoung; Kwak-Kim, Joanne; Koo, H S; Yang, K M

2016-09-01

To investigate hCG-β level on postovulatory day (POD) 12 and its fold increase as predictors for pregnancy outcome after in vitro fertilization (IVF) cycles. A retrospective cohort study was performed in total 1408 fresh and 598 frozen cycles between November 2008 and October 2011, which resulted in biochemical pregnancy, early pregnancy loss, or live birth of singleton pregnancy. The serum hCG-β levels of POD 12 and 14 were compared among biochemical pregnancy, early pregnancy loss, and live birth groups. The cutoff values of POD 12 and 14 hCG-β levels and the degree of hCG-β increase from POD 12 to 14 were determined for each pregnancy outcome. POD 12 and 14 hCG-β levels stratified based on pregnancy outcomes were significantly different among the biochemical pregnancy, early pregnancy loss, and live birth in both fresh and frozen cycles. Serum hCG-β levels of POD 12 and 14 and the fold increase of hCG-β levels from POD 12 to 14 significantly predict pregnancy outcomes after fresh and frozen cycles. Among these, the cutoff value of POD 14 hCG-β had the highest sensitivity and positive predictive value (PPV). In fresh cycles, the cutoff values of POD 12 and 14 serum hCG-β levels for clinical pregnancies were 30.2 mIU/mL (sensitivity 81.3 %, specificity 79.6 %, and PPV 92.3 %) and 70.5 mIU/mL (sensitivity 88.4 %, specificity 85.2 %, and PPV 94.7 %). In pregnancies with POD 12 serum hCG-β levels ≥30.2 mIU/mL, the cutoff level of increase of hCG-β for clinical pregnancy was 2.56 (sensitivity 73.6 %, specificity 72.4 %, and PPV 97.8 %). Sequential application of cutoff values such as POD 12 hCG-β and fold increase of hCG-β improved predictability of pregnancy outcome as compared with that of POD 12 hCG-β alone. The cutoff values of POD 12 and 14 serum hCG-β levels for live birth were 40.5 mIU/mL (sensitivity 75.2 %, specificity 72.6 %, PPV 78.9 %) and 104.5 mIU/mL (sensitivity 80.3 %, specificity 74.1 %, PPV 80.8 %). In the frozen cycles, the cutoff values of POD 12 and 14 serum hCG-β level for clinical pregnancy were 31.5 IU/L (sensitivity 80.4 %, specificity 71.1 % and PPV 90 %) and 43.5 mIU/mL (sensitivity 72.6 %, specificity 71.7 %, PPV 77.2 %). In pregnancies with POD 12 serum hCG-β level ≥31.5 mIU/mL, the cutoff value for fold increase of hCG-β was 2.38 for clinical pregnancy (sensitivity 81.6 %, specificity 71.4 % and PPV 87.9 %). The cutoff values of POD 12 and 14 for live birth were 43.5 mIU/mL (sensitivity 72.6 %, specificity 71.7 %, PPV 77.2 %) and 101.6 mIU/mL (sensitivity 79.6 %, specificity 71.1 %, PPV 78.4 %). Sequential application of cutoff values for POD 12 hCG-β level and fold increase of hCG-β significantly increased PPV for live birth but not clinical pregnancy in frozen cycles. Early prediction of pregnancy outcome by using POD 12 and 14 cutoff levels and sequential application of cutoff value of fold increase could provide appropriate reference to health care providers to initiate earlier management of high-risk pregnancies and precise follow-up of abnormal pregnancies.

Special issue on eHealth and mHealth: Challenges and future directions for assessment, treatment, and dissemination.

PubMed

Borrelli, Belinda; Ritterband, Lee M

2015-12-01

This special issue is intended to promote a discussion of eHealth and mHealth and its connection with health psychology. "eHealth" generally refers to the use of information technology, including the Internet, digital gaming, virtual reality, and robotics, in the promotion, prevention, treatment, and maintenance of health. "mHealth" refers to mobile and wireless applications, including text messaging, apps, wearable devices, remote sensing, and the use of social media such as Facebook and Twitter, in the delivery of health related services. This special issue includes 11 articles that begin to address the need for more rigorous methodology, valid assessment, innovative interventions, and increased access to evidence-based programs and interventions. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

Electronic structure, stability and magnetic properties of small M1-2Cr (M = Fe, Co, and Ni) alloy encapsulated inside a (BN)48 cage

NASA Astrophysics Data System (ADS)

Liang, Wenjuan; Jia, Jianfeng; Lv, Jin; Wu, Haishun

2015-09-01

The geometrical structure and magnetic properties of M1-2Cr (M = Fe, Co, and Ni) alloy clusters inside a (BN)48 cage were calculated at the BPW91/LANL2DZ level of theory. The doping with Cr significantly changed the magnetic properties of the transition-metal clusters. When M1-2Cr alloys were placed inside a (BN)48 cage, the alloy clusters interacted strongly with the cage, and the M1-2Cr@(BN)48 clusters showed high stability. Moreover, Cr-doped magnetic metal clusters preferably occupied positions off-center and near the hexagonal rings of (BN)48 cages. Thus, the (BN)48 cages can be used to increase the stability of M1-2Cr alloys, and retain their magnetic nature, except for CoCr and Ni2Cr clusters.

"It's worth our time": a model of culturally and linguistically supportive professional development for K-12 STEM educators

NASA Astrophysics Data System (ADS)

Charity Hudley, Anne H.; Mallinson, Christine

2017-09-01

Professional development on issues of language and culture is often separate from professional development on issues related to STEM education, resulting in linguistic and cultural gaps in K-12 STEM pedagogy and practice. To address this issue, we have designed a model of professional development in which we work with educators to build cultural and linguistic competence and to disseminate information about how educators view the relevance of language, communication, and culture to STEM teaching and learning. We describe the design and facilitation of our model of culturally and linguistically responsive professional development, grounded in theories of multicultural education and culturally supportive teaching, through professional development workshops to 60 K-12 STEM educators from schools in Maryland and Virginia that serve African American students. Participants noted that culturally and linguistically responsive approaches had yet to permeate their K-12 STEM settings, which they identified as a critical challenge to effectively teaching and engaging African-American students. Based on pre-surveys, workshops were tailored to participants' stated needs for information on literacy (e.g., disciplinary literacies and discipline-specific jargon), cultural conflict and mismatch (e.g., student-teacher miscommunication), and linguistic bias in student assessment (e.g., test design). Educators shared feedback via post-workshop surveys, and a subset of 28 participants completed in-depth interviews and a focus group. Results indicate the need for further implementation of professional development such as ours that address linguistic and cultural issues, tailored for K-12 STEM educators. Although participants in this study enumerated several challenges to meeting this need, they also identified opportunities for collaborative solutions that draw upon teacher expertise and are integrated with curricula across content areas.

mTOR inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion.

PubMed

Tang, Ying; Fang, Qi; Shi, Daohua; Niu, Peiguang; Chen, Yaoyao; Deng, Jie

2014-03-18

Cardamonin has previously demonstrated that it had an antiproliferative effect on vascular smooth muscle cells by inhibiting the activity of mammalian target of rapamycin (mTOR). The antiproliferative effect and the possible mechanism of combining with mTOR of cardamonin were investigated on A549 cells. Cell proliferation, cell cycle and apoptosis were measured by methyl thiazolyl tetrazolium (MTT) and flow cytometry, respectively. mTOR and 12 kDa FK506 binding protein (FKBP12) were transfected into A549 cells by Lipofectamine. Western blots were used to examine the mTOR expressions and its activities, and the expressions of 70 kDa ribosomal S6 kinase (p70S6K), FKBP12 and Interleukin-2 (IL-2), respectively. Treated with cardamonin, the proliferation of A549 cells was inhibited. Meanwhile, cell cycle was blocked and DNA synthesis was decreased whereas cell apoptosis was promoted, and the activation of mTOR and p70S6K was decreased by cardamonin. Transfected with mTOR or FKBP12, proliferation of A549 cells was increased. Rapamycin had a similar degree of effect on antiproliferation of both transfected cells. However, the antiproliferative effect of cardamonin on mTOR transfected cells was stronger than that on FKBP12 transfected cells. Both rapamycin and cardamonin decreased the phosphorylation of mTOR and p70S6K in two kinds of transfected cells. Cardamonin had no effect on the expression of FKBP12 and IL-2, whereas the expressions were decreased by rapamycin. Cardamonin inhibited proliferation and induced apoptosis of A549 cells via mTOR. It might directly interact with mTOR independently of binding with FKBP12. Copyright © 2014 Elsevier Inc. All rights reserved.

Evaluation of Vitamin B12 Deficiency and Associated Factors in Patients With Systemic Sclerosis.

PubMed

Tas Kilic, Diler; Akdogan, Ali; Kilic, Levent; Sari, Alper; Erden, Abdulsamet; Armagan, Berkan; Kilickaya, Muhammed; Kalyoncu, Umut; Turhan, Turan; Kiraz, Sedat; Karaahmetoglu, Selma

2018-01-30

In patients with systemic sclerosis (SSc) gastrointestinal (GI) involvement, nutritional status and medications may lead to cobalamin (Vit B12) deficiency. We aimed to determine the frequency and the potential causes of Vit B12 deficiency in SSc patients. We conducted a cross-sectional analysis of 62 SSc patients in a single center in 1 year period. Medical history and physical examination of patients were reevaluated. Data about organ involvements were obtained from hospital file records. The nutritional status of the patients was assessed with Malnutrition Universal Screening Tool (MUST). Vit B12, homocysteine (except in three patients) and Helicobacter Pylori Immunoglobulin G (H. Pylori IgG) levels were measured in all patients. Vit B12 deficiency was considered as serum Vit B12 level <200 pg/mL or being on Vit B12 replacement therapy. Serum Vit B12 levels of the patients were also grouped as low (<200 pg/mL), borderline (200-300 pg/mL) and normal (>300 pg/mL). Plasma homocysteine levels of the patients were classified as elevated (>9 μmol/L) and hyperhomocysteinemia (>15 μmol/L). Mann-Whitney U and Kruskal-Wallis tests were used to compare parameters among the groups. Correlation was tested by Spearman's correlation coefficient. Forty-four (71.0%) patients were defined as Vit B12 deficient; 22 had Vit B12 level <200 pg/mL (four were on Vit B12 replacement therapy) and the remaining 22 had Vit B12 >200 pg/mL and were already on Vit B12 replacement therapy. The percentage of the patients with hyperhomocysteinemia was significantly higher in the group with Vit B12 <200 pg/mL as compared to other groups (P = 0.004) but only 33.3% (7/21) of the patients with Vit B12 <200 pg/mL had hyperhomocysteinemia. There were no statistically significant differences between patients with and without Vit B12 deficiency regarding age, mean disease duration, MUST scores, mean hemoglobin levels, H. Pylori IgG positivity and organ involvements (P > 0.05 for all). Vit B12 deficiency is frequent in SSc and has multiple causes. All patients should be monitored for Vit B12 deficiency. The homocysteine levels seem unlikely to be helpful for confirmation of Vit B12 deficiency.

A longitudinal investigation into the functional and physical durability of insoles used for the preventive management of neuropathic diabetic feet.

PubMed

Paton, Joanne S; Stenhouse, Elizabeth; Bruce, Graham; Jones, Ray

2014-01-01

Insoles are commonly used to assist in the prevention of diabetic neuropathic foot ulceration. Insole replacement is often triggered only when foot lesions deteriorate, an indicator that functional performance is comprised and patients are exposed to unnecessary ulcer risk. We investigated the durability of insoles used for ulcer prevention in neuropathic diabetic feet over 12 months. Sixty neuropathic individuals with diabetes were provided with insoles and footwear. Insole durability over 12 months was evaluated using an in-shoe pressure measurement device and through repeated measurement of material depth at the first metatarsal head and the heel seat. Analysis of variance was performed to assess change across time (at issue, 6 months, and 12 months). Analyses were conducted using all available data (n = 43) and compliant data (n = 18). No significant difference was found in the reduction of mean peak pressure tested across time (P < .05). For both sites, significant differences in insole depth were identified between issue and 6 months and between issue and 12 months but not between 6 and 12 months (P < .05). Most insole compression occurred during the initial 6 months. Visual material compression does not seem to be a reliable indicator of insole usefulness. Frequency of insole replacement is best informed by a functional review of effect determined using an in-shoe pressure measurement system. These results suggest that insoles for diabetic neuropathic patients can be effective in maintaining peak pressure reduction for 12 months regardless of wear frequency.

Malaysia, Singapore. Section 23. Revision. Weather and Climate

DTIC Science & Technology

1969-08-01

12 12 10 0 20 13 16 is 17 104 6-10 Rom porn iii ............... 10 6 9 1:2 16 11 12 13 11 13 14 13 140 8-61 Rtbu .... ............... 22 17 17 17 17 13...11 Days with precipitation 190,01 inch (map) .................. 15 Fig. 12 M ean cloudiness (map) ..................................... 16 Fig. 13...SANDAKAN Ald 80 01 L, ao 1 011 7A" 10 10 so 75 -1 76 13 79 74. 16 79 16 79 17 16 I I if-00 Ill f M A MIJI)JAISJOINIk 22 M i F m A Y, 71, 711 75

Empowering Interagency Capabilities: A Regional Approach

DTIC Science & Technology

2006-05-25

National Security Issue of the Early 21st Century”........................................................... 10 What does it all mean ? .............................................................................................................. 12...These issues only increase in the future environment described by both Kaplan and the JOE. What does it all mean ? While each of these views brings

Panel Sessions.

ERIC Educational Resources Information Center

Proceedings of the ASIS Mid-Year Meeting, 1992

1992-01-01

Lists the speakers and summarizes the issues addressed for 12 panel sessions on topics related to networking, including libraries and national networks, federal national resources and energy programs, multimedia issues, telecommuting, remote image serving, accessing the Internet, library automation, scientific information, applications of Z39.50,…

Controversial Issues Confronting Special Education: Divergent Perspectives.

ERIC Educational Resources Information Center

Stainback, William; Stainback, Susan

This book of 24 papers presents divergent views on 12 issues in special education: organizational strategies, classroom service delivery approaches, maximizing the talents and gifts of students, classification and labeling, assessment, instructional strategies, classroom management, collaboration/consultation, research practices, higher education,…

50 CFR 22.12 - What activities are illegal?

Code of Federal Regulations, 2010 CFR

2010-10-01

... (Aquila chrysaetos), or the parts, nests, or eggs of these birds, and we will not issue a permit to... eagle, or any live egg of those birds, and we will not issue a permit to authorize these acts. [64 FR...

IDRA Newsletter, 1999.

ERIC Educational Resources Information Center

Montecel, Maria Robledo, Ed.; Goodman, Christie L., Ed.

1999-01-01

The 10 issues of IDRA Newsletter published in 1999 focus on education in Texas and on educational issues concerning minority, low-income, or bilingual students. Feature articles include: "Lost: $319 Billion and 1.2 Million Students" (Texas dropouts); "Breathing New Life into Language Assessment"; "Missing: Texas…

12 CFR 1024.17 - Escrow accounts.

Code of Federal Regulations, 2013 CFR

2013-01-01

... shortages, surpluses or deficiencies exist. Escrow account computation year is a 12-month period that a... includes each 12-month period thereafter, unless a servicer chooses to issue a short year statement under... cushion is two months of the borrower's escrow payments to the servicer or a lesser amount specified by...

12 CFR 1024.17 - Escrow accounts.

Code of Federal Regulations, 2012 CFR

2012-01-01

... shortages, surpluses or deficiencies exist. Escrow account computation year is a 12-month period that a... includes each 12-month period thereafter, unless a servicer chooses to issue a short year statement under... cushion is two months of the borrower's escrow payments to the servicer or a lesser amount specified by...

29 CFR 31.12 - Effect on other regulations; supervision and coordination.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... 31.12 Section 31.12 Labor Office of the Secretary of Labor NONDISCRIMINATION IN FEDERALLY ASSISTED... be deemed to supersede any of the following (including future amendments thereof): (1) Executive... Personnel Administration,” issued jointly by the Secretaries of Defense, of Health, Education and Welfare...

Chronicle of Higher Education. Volume 51, Number 12, November 12, 2004

ERIC Educational Resources Information Center

Chronicle of Higher Education, 2004

2004-01-01

"Chronicle of Higher Education" presents an abundant source of news and information for college and university faculty members and administrators. This November 12, 2004 issue of "Chronicle for Higher Education" includes the following articles: (1) "The Transcendent Role of Chaplains" (Schaper, Donna); (2) "Offbeat Director's Sophistication Isn't…

46 CFR 12.809 - Citizenship and identity.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Citizenship and identity. 12.809 Section 12.809 Shipping....809 Citizenship and identity. (a) Instead of the requirements of § 10.221 of this subchapter, a non... identity requirements of this subpart, an applicant must present an unexpired passport issued by the...

12 CFR 1.100 - Indirect general obligations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... powers of taxation. Pursuant to § 1.2(b), an obligation issued by an obligor not possessing general powers of taxation qualifies as a general obligation of a State or political subdivision for the purposes of 12 U.S.C. 24 (Seventh), if a party possessing general powers of taxation unconditionally promises...

40 CFR 21.12 - State issued statements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 21.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SMALL BUSINESS § 21.12 State... where he has or is receiving from the small business concern applicant 10 percent of gross personal... year if the recipient is over 60 years of age and is receiving such portion pursuant to retirement...

Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin-12/interleukin-23-deficient mice

PubMed Central

Bastos, Karina R B; de Deus Vieira de Moraes, Luciana; Zago, Cláudia A; Marinho, Cláudio R F; Russo, Momtchilo; Alvarez, José M M; D'Império Lima, Maria R

2005-01-01

We have previously shown that macrophages from interleukin (IL)-12p40 gene knockout (IL-12/IL-23−/−) mice have a bias towards the M2 activation profile, spontaneously secreting large quantities of transforming growth factor-β1 (TGF-β1) and producing low levels of nitric oxide (NO) in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ). To verify whether the activation profile of dendritic cells (DCs) is also influenced by the absence of IL-12/IL-23, bone marrow-derived DCs from IL-12/IL-23−/− and C57BL/6 mice were evaluated. At first we noticed that ≈ 50% of the C57BL/6 DCs were dead after LPS-induced maturation, whereas the mortality of IL-12/IL-23−/− DCs was < 10%, a protective effect that diminished when recombinant IL-12 (rIL-12) was added during maturation. Similarly to macrophages, mature IL-12/IL-23−/− DCs (mDCs) produced higher levels of TGF-β1 and lower levels of NO than C57BL/6 mDCs. NO release was IFN-γ-dependent, as evidenced by the poor response of IFN-γ−/− and IL-12/IL-23−/−IFN-γ−/− mDCs. Nevertheless, IFN-γ deficiency was not the sole reason for the weak NO response observed in the absence of IL-12/IL-23. The high level of TGF-β1 secretion by IL-12/IL-23−/− mDCs could explain why exogenous IFN-γ partially restored the NO production of IFN-γ−/− mDCs, while IL-12/IL-23−/− IFN-γ−/− mDCs remained unresponsive. We also showed that CD4+ T-cell proliferation was inhibited by C57BL/6 mDCs, but not by IL-12/IL-23−/− mDCs. IFN-γ and NO appear to mediate this antiproliferative effect because this effect was not observed in the presence of mDCs from IFN-γ−/− or IL-12/IL-23−/− IFN-γ−/− mice and it was attenuated by aminoguanidine. We conclude that the presence of IL-12/IL-23 during LPS-induced maturation influences the activation profile of DCs by a mechanism that is, only in part, IFN-γ dependent. PMID:15804287

Social maturity and theory of mind in typically developing children and those on the autism spectrum.

PubMed

Peterson, Candida C; Slaughter, Virginia P; Paynter, Jessica

2007-12-01

Results of several studies using the Vineland scale to explore links between social behavior and theory of mind (ToM) have produced mixed results, especially for children on the autism spectrum. The present pair of studies developed a psychometrically sound, age-referenced measure of social maturity to explore these issues further. In Study 1, 37 typically developing preschoolers took a battery of standard false belief tests of ToM and were rated by their teachers on a newly developed age-referenced social maturity scale with 7 items. In Study 2, a further group of 43 children aged 4 to 12 years (13 with autism, 14 with Asperger's disorder and 16 with typical development) took part in the same procedure. In Study 1, ToM was found to predict typical preschoolers' social maturity independently of age and verbal maturity. In Study 2, children with autism scored below age-matched and younger typical developers in both ToM and social maturity. Those with Asperger's disorder did well on ToM but poorly on social maturity. Study 2 replicated Study 1's finding (for typical children and for the full sample) that ToM was linked with social maturity independently of age and verbal ability, although the link was not independent of autism diagnosis. Teachers are capable of rating children's social behavior with peers as advanced, on-time or delayed for their age. Suggestive links between these ratings and ToM require further investigation, especially among children on the autism spectrum.

Operational correction and validation of the VIIRS TEB longwave infrared band calibration bias during blackbody temperature changes

NASA Astrophysics Data System (ADS)

Wang, Wenhui; Cao, Changyong; Ignatov, Alex; Li, Zhenglong; Wang, Likun; Zhang, Bin; Blonski, Slawomir; Li, Jun

2017-09-01

The Suomi NPP VIIRS thermal emissive bands (TEB) have been performing very well since data became available on January 20, 2012. The longwave infrared bands at 11 and 12 um (M15 and M16) are primarily used for sea surface temperature (SST) retrievals. A long standing anomaly has been observed during the quarterly warm-up-cool-down (WUCD) events. During such event daytime SST product becomes anomalous with a warm bias shown as a spike in the SST time series on the order of 0.2 K. A previous study (CAO et al. 2017) suggested that the VIIRS TEB calibration anomaly during WUCD is due to a flawed theoretical assumption in the calibration equation and proposed an Ltrace method to address the issue. This paper complements that study and presents operational implementation and validation of the Ltrace method for M15 and M16. The Ltrace method applies bias correction during WUCD only. It requires a simple code change and one-time calibration parameter look-up-table update. The method was evaluated using colocated CrIS observations and the SST algorithm. Our results indicate that the method can effectively reduce WUCD calibration anomaly in M15, with residual bias of 0.02 K after the correction. It works less effectively for M16, with residual bias of 0.04 K. The Ltrace method may over-correct WUCD calibration biases, especially for M16. However, the residual WUCD biases are small in both bands. Evaluation results using the SST algorithm show that the method can effectively remove SST anomaly during WUCD events.

Increasing the Kill Effectiveness of High Energy Laser (HEL) Combat System

DTIC Science & Technology

2015-03-01

mm Machine Gun These versatile craft are Chinese imports. Some vessels have been configured without missiles in order to carry the larger MLRS...Displacement: 28.16 tons Armament: (2) 533 mm Torpedo Tubes Length: 21.12 m (1) 12.7 machine gun Beam: 5.77 m Draft: 0.87 m Speed: 20.6 m/s...m (2) Nasr ASM Draft: 0.67 m (2) 12.7 mm machine gun Speed: 26.7 m/s The original, low-observable torpedo boat, IPS-16 was imported from

Impact penetration experiments in teflon targets of variable thickness

NASA Astrophysics Data System (ADS)

Hoerz, F.; Cintala, M. J.; Bernhard, R. P.; See, T. H.

1993-03-01

Approximately 20.4 sq m of Teflon thermal blankets on the nonspinning Long Duration Exposure Facility (LDEF) were exposed to the orbital debris and micrometeoroid environment in low-Earth orbit (LEO) for approximately 5.7 years. Each blanket consisted of an outer layer (approximately 125 micron thick) of FEP Teflon that was backed by a vapor-deposited metal mirror (Inconel; less than 1 micron thick). The inner surface consisted of organic binders and Chemglaze thermal protective paint (approximately 50 micron thick) resulting in a somewhat variable, total blanket thickness of approximately 180 to 200 microns. There was at least one of these blankets, each exposing approximately 1.2 sq m of surface area, on nine of LDEF's 12 principal pointing directions, the exceptions being Rows 3, 9, and 12. As a consequence, these blankets represent a significant opportunity for micrometeoroid and debris studies, in general, and specifically they provide an opportunity to address those issues that require information about pointing direction (i.e., spatial density of impact events as a function of instrument orientation). During deintegration of the LDEF spacecraft at KSC, all penetration holes greater than or equal to 300 micron in diameter were documented and were recently synthesized in terms of spatial density as a function of LDEF viewing direction by. The present report describes ongoing cratering and penetration experiments in pure Teflon targets, which are intended to establish the relationships between crater or penetration-hole diameters and the associated projectile dimensions at laboratory velocities (i.e., 6 km/s). The ultimate objective of these efforts is to extract reliable mass-frequencies and associated fluxes of hypervelocity particles in LEO.

Sulfonate-ended carbosilane dendrimers with a flexible scaffold cause inactivation of HIV-1 virions and gp120 shedding.

PubMed

Sepúlveda-Crespo, Daniel; de la Mata, Francisco J; Gómez, Rafael; Muñoz-Fernández, Mª A

2018-05-17

Infection with human immunodeficiency virus type 1 (HIV-1) continues to be a global public health issue, especially in low-resource countries. Sexual transmission is responsible for the majority of HIV-1 infections worldwide. Women are more susceptible to HIV-1 acquisition than men and represent nearly 50% of the HIV-infected population. Topical vaginal microbicides that act at the earlier stages of infection offer a prevention strategy to reduce the acquisition of HIV-1. Dendrimers are nano-sized, radially symmetric molecules with a well-defined and monodisperse structure consisting of tree-like arms or branches. We perform a TZM.bl cell line-based screening of two families of carbosilane dendrimers (6 nanocompounds: G1-S12P, G2-S24P, G3-S48P, G1-C12P, G2-C24P and G3-C48P) that we have previously synthesized, containing 12, 24 or 48 sulfonate (or carboxylate) end-groups and a polyphenolic core. This work shows that second- and third-generation sulfonate-ended carbosilane dendrimers with a polyphenolic core (G2-S24P and G3-S48P, respectively) display low cytotoxicity (CC50 > 300 μM) with virucidal anti-R5-HIV-1 activity (EC50 < 50 nM; therapeutic index >6000) causing irreversible HIV-1 inactivation (80-90%) by loss of HIV-1 RNA (40%), gp120 shedding (70-80%) and p24 capsid protein release (45-60%). Herein, we demonstrate that sulfonate end-groups and a flexible scaffold from carbosilane dendrimers strongly influence their properties acting as potent virucides.

Army Sustainment. Volume 41, Issue 6. November-December 2009

DTIC Science & Technology

2009-12-01

00-11-2009 to 00-12-2009 4. TITLE AND SUBTITLE Army Sustainment. Volume 41, Issue 6. November-December 2009 5a. CONTRACT NUMBER 5b. GRANT NUMBER...VOLUME 41 ISSUE 6 NOVEMBER–DECEMBER 2009 www.almc.army.mil/alog 5 8 11 14 16 18 20 21 22 25 Cover: This issue focuses on a major development in the...Is Open for Business —Colonel Shelley A. Richardson and Lieutenant Colonel Tim Gilhool Sustainment Center of Excellence Simulation Training

Client-Focused Security Assessment of mHealth Apps and Recommended Practices to Prevent or Mitigate Transport Security Issues.

PubMed

Müthing, Jannis; Jäschke, Thomas; Friedrich, Christoph M

2017-10-18

Mobile health (mHealth) apps show a growing importance for patients and health care professionals. Apps in this category are diverse. Some display important information (ie, drug interactions), whereas others help patients to keep track of their health. However, insufficient transport security can lead to confidentiality issues for patients and medical professionals, as well as safety issues regarding data integrity. mHealth apps should therefore deploy intensified vigilance to protect their data and integrity. This paper analyzes the state of security in mHealth apps. The objectives of this study were as follows: (1) identification of relevant transport issues in mHealth apps, (2) development of a platform for test purposes, and (3) recommendation of practices to mitigate them. Security characteristics relevant to the transport security of mHealth apps were assessed, presented, and discussed. These characteristics were used in the development of a prototypical platform facilitating streamlined tests of apps. For the tests, six lists of the 10 most downloaded free apps from three countries and two stores were selected. As some apps were part of these top 10 lists in more than one country, 53 unique apps were tested. Out of the 53 apps tested from three European App Stores for Android and iOS, 21/53 (40%) showed critical results. All 21 apps failed to guarantee the integrity of data displayed. A total of 18 apps leaked private data or were observable in a way that compromised confidentiality between apps and their servers; 17 apps used unprotected connections; and two apps failed to validate certificates correctly. None of the apps tested utilized certificate pinning. Many apps employed analytics or ad providers, undermining user privacy. The tests show that many mHealth apps do not apply sufficient transport security measures. The most common security issue was the use of any kind of unprotected connection. Some apps used secure connections only for selected tasks, leaving all other traffic vulnerable. ©Jannis Müthing, Thomas Jäschke, Christoph M Friedrich. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 18.10.2017.

Health-related quality of life in children and adolescents who use cochlear implants.

PubMed

Warner-Czyz, Andrea D; Loy, Betty; Tobey, Emily A; Nakonezny, Paul; Roland, Peter S

2011-01-01

Examination of health-related quality of life (HRQoL) in children and adolescents who wear a cochlear implant (CI) primarily has depended on parent proxy report of the child's HRQoL rather than child self-report and generic domains rather than CI-specific issues. This study simultaneously assessed self-report ratings on a generic HRQoL instrument and a preliminary CI module in pediatric CI users. The impact of demographic factors (chronologic age, age at CI, and CI experience) on HRQoL also was explored. This cross-sectional study included 138 children grouped by chronologic age: 4-7, 8-11 and 12-16 years. The KINDL(R) questionnaire for measuring HRQoL in children and adolescents (generic) and a preliminary CI module (specific) were completed as a researcher-administered interview (4-7 years) or self-administered questionnaire (8-16 years) at CI summer camp or home. Scores were transformed to a 100-point scale with 100 representing the most positive response. The impact of chronologic age group on HRQoL ratings was evaluated using Analysis of Variance. Spearman rank-order correlations and point-biserial correlations tested associations between demographic factors and HRQoL scores. Principal factor analysis was used to discover the factor structure and internal consistency of the preliminary CI module. The youngest group (M=82.8) rated generic HRQoL significantly more positively than older children (8-11 years: M=75.3; 12-16 years: M=70.4). Similar significant results emerged on the overall CI module (4-7 years: M=79.8; 8-11 years: M=77.8; 12-16 years: M=71.3). The youngest group rated CI-specific items on friends and self-image more positively than older groups, but reported greater difficulties hearing teachers at school. The oldest group provided more consistent responses than younger groups on the CI module (Cronbach α=0.72). Generic and CI module scores correlated positively (r=0.19, p=.03) but this association reflects the strong correlation in the oldest group (r=0.49, p=0.0033) and camouflages non-significant results in younger groups. Chronologic age impacts self-report of HRQoL for pediatric CI users such that younger children rate HRQoL more positively than older children and adolescents on a generic instrument and preliminary CI module. Older children provide more consistent responses on the CI module. Results support the need for further development of a CI-specific self-report HRQoL instrument. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia

PubMed Central

Scarr, Elizabeth; Udawela, Madhara; Greenough, Mark A; Neo, Jaclyn; Suk Seo, Myoung; Money, Tammie T; Upadhyay, Aradhana; Bush, Ashley I; Everall, Ian P; Thomas, Elizabeth A; Dean, Brian

2016-01-01

Our expression microarray studies showed messenger RNA (mRNA) for solute carrier family 39 (zinc transporter), member 12 (SLC39A12) was higher in dorsolateral prefrontal cortex from subjects with schizophrenia (Sz) in comparison with controls. To better understand the significance of these data we ascertained whether SLC39A12 mRNA was altered in a number of cortical regions (Brodmann’s area (BA) 8, 9, 44) from subjects with Sz, in BA 9 from subjects with mood disorders and in rats treated with antipsychotic drugs. In addition, we determined whether inducing the expression of SLC39A12 resulted in an increased cellular zinc uptake. SLC39A12 variant 1 and 2 mRNA was measured using quantitative PCR. Zinc uptake was measured in CHO cells transfected with human SLC39A12 variant 1 and 2. In Sz, compared with controls, SLC39A12 variant 1 and 2 mRNA was higher in all cortical regions studied. The were no differences in levels of mRNA for either variant of SLC39A12 in BA 9 from subjects with mood disorders and levels of mRNA for Slc39a12 was not different in the cortex of rats treated with antipsychotic drugs. Finally, expressing both variants in CHO-K1 cells was associated with an increase in radioactive zinc uptake. As increased levels of murine Slc39a12 mRNA has been shown to correlate with increasing cellular zinc uptake, our data would be consistent with the possibility of a dysregulated zinc homeostasis in the cortex of subjects with schizophrenia due to altered expression of SLC39A12. PMID:27336053

17 CFR 240.12g-3 - Registration of securities of successor issuers under section 12(b) or 12(g).

Code of Federal Regulations, 2012 CFR

2012-04-01

...(g). (a) Where in connection with a succession by merger, consolidation, exchange of securities... 12 of the Act unless upon consummation of the succession: (1) Such class is exempt from such... persons; or (3) The securities issued in connection with the succession were registered on Form F-8 or...

17 CFR 240.12g-3 - Registration of securities of successor issuers under section 12(b) or 12(g).

Code of Federal Regulations, 2011 CFR

2011-04-01

...(g). (a) Where in connection with a succession by merger, consolidation, exchange of securities... 12 of the Act unless upon consummation of the succession: (1) Such class is exempt from such... persons; or (3) The securities issued in connection with the succession were registered on Form F-8 or...

17 CFR 240.12g-3 - Registration of securities of successor issuers under section 12(b) or 12(g).

Code of Federal Regulations, 2014 CFR

2014-04-01

...(g). (a) Where in connection with a succession by merger, consolidation, exchange of securities... 12 of the Act unless upon consummation of the succession: (1) Such class is exempt from such... persons; or (3) The securities issued in connection with the succession were registered on Form F-8 or...

17 CFR 240.12g-3 - Registration of securities of successor issuers under section 12(b) or 12(g).

Code of Federal Regulations, 2013 CFR

2013-04-01

...(g). (a) Where in connection with a succession by merger, consolidation, exchange of securities... 12 of the Act unless upon consummation of the succession: (1) Such class is exempt from such... persons; or (3) The securities issued in connection with the succession were registered on Form F-8 or...

17 CFR 240.12g-3 - Registration of securities of successor issuers under section 12(b) or 12(g).

Code of Federal Regulations, 2010 CFR

2010-04-01

...(g). (a) Where in connection with a succession by merger, consolidation, exchange of securities... 12 of the Act unless upon consummation of the succession: (1) Such class is exempt from such... persons; or (3) The securities issued in connection with the succession were registered on Form F-8 or...

New Mexico K-12 & School Choice Survey: What Do Voters Say about K-12 Education? Polling Paper Number 4

ERIC Educational Resources Information Center

DiPerna, Paul

2011-01-01

The "New Mexico K-12 & School Choice Survey" project, commissioned by The Friedman Foundation for Educational Choice and conducted by Braun Research Incorporated (BRI), measures New Mexico voters' familiarity and views on a range of K-12 education issues and school choice reforms. The author and his colleagues report response…

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells

PubMed Central

Wauson, Eric M.; Guerra, Marcy L.; Dyachok, Julia; McGlynn, Kathleen; Giles, Jennifer; Ross, Elliott M.

2015-01-01

The MAPKs ERK1/2 respond to nutrients and other insulin secretagogues in pancreatic β-cells and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the mechanistic target of rapamycin complex 1 (mTORC1) to regulate protein synthesis. We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic β-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor. We show here that AAs differentially activate these two signaling pathways in MIN6 cells. Pretreatment with pertussis toxin did not prevent the activation of either ERK1/2 or mTORC1 by AAs, indicating that Gi is not central to either pathway. Although glucagon-like peptide 1, an agonist for a Gs-coupled receptor, activated ERK1/2 well and mTORC1 to a small extent, AAs had no effect on cytosolic cAMP accumulation. Ca2+ entry is required for ERK1/2 activation by AAs but is dispensable for AA activation of mTORC1. Pretreatment with UBO-QIC, a selective Gq inhibitor, reduced the activation of ERK1/2 but had little effect on the activation of mTORC1 by AAs, suggesting a differential requirement for Gq. Inhibition of G12/13 by the overexpression of the regulator of G protein signaling domain of p115 ρ-guanine nucleotide exchange factor had no effect on mTORC1 activation by AAs, suggesting that these G proteins are also not involved. We conclude that AAs regulate ERK1/2 and mTORC1 through distinct signaling pathways. PMID:26168033

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.

PubMed

Wauson, Eric M; Guerra, Marcy L; Dyachok, Julia; McGlynn, Kathleen; Giles, Jennifer; Ross, Elliott M; Cobb, Melanie H

2015-08-01

The MAPKs ERK1/2 respond to nutrients and other insulin secretagogues in pancreatic β-cells and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the mechanistic target of rapamycin complex 1 (mTORC1) to regulate protein synthesis. We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic β-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor. We show here that AAs differentially activate these two signaling pathways in MIN6 cells. Pretreatment with pertussis toxin did not prevent the activation of either ERK1/2 or mTORC1 by AAs, indicating that G(I) is not central to either pathway. Although glucagon-like peptide 1, an agonist for a G(s-)coupled receptor, activated ERK1/2 well and mTORC1 to a small extent, AAs had no effect on cytosolic cAMP accumulation. Ca(2+) entry is required for ERK1/2 activation by AAs but is dispensable for AA activation of mTORC1. Pretreatment with UBO-QIC, a selective G(q) inhibitor, reduced the activation of ERK1/2 but had little effect on the activation of mTORC1 by AAs, suggesting a differential requirement for G(q). Inhibition of G(12/13) by the overexpression of the regulator of G protein signaling domain of p115 ρ-guanine nucleotide exchange factor had no effect on mTORC1 activation by AAs, suggesting that these G proteins are also not involved. We conclude that AAs regulate ERK1/2 and mTORC1 through distinct signaling pathways.

From Orthodoxy to Plurality in the Nature of Science (NOS) and Science Education: A Metacommentary

ERIC Educational Resources Information Center

Bazzul, Jesse

2017-01-01

This article provides a metacommentary on the special issue on nature of science (NOS). The issue is composed of senior scholars discussing Hodson and Wong's (2017, this issue) critique of the consensus view of nature of science, which on a basic level states that there are agreed-upon aspects of science that can be taught in K-12 schools. Each…

An Index to the Caricatures in the "New York Review of Books" from Its Inception Through the Fifteenth Anniversary Issue (1963-1978).

ERIC Educational Resources Information Center

Drazan, Joseph Gerald; Sanguine, Phyllis

This index identifies caricatures drawn by David Levine which are found in the "New York Review of Books" from its first issue in 1963 through the special fifteenth anniversary issue dated October 12, 1978. The index is arranged alphabetically by surname for each personality caricatured, with some cross references. The numbering system…

UCAC and URAT: Optical Astrometric Catalog Observing Programs

DTIC Science & Technology

2010-09-21

12 100 K 1.0 1997 Tycho-2 G/S yes <= 12 2.5 M 10..100 2000 UCAC G yes 8..16 100 M 20.. 70 2004+ 2MASS G no IR...UCAC3 G yes 8..16 100 M 20.. 70 2009 first CCD survey 2MASS G no IR 500 M 90 2003 1 epoch USNO-B G yes 12..21 1000 M 200 2003 Schmidt plates PanSTARRS G

Phosphate determination in seawater: toward an autonomous electrochemical method.

PubMed

Jońca, Justyna; León Fernández, Violeta; Thouron, Danièle; Paulmier, Aurélien; Graco, Michelle; Garçon, Véronique

2011-12-15

Initial steps to create an autonomous in situ electrochemical sensor for orthophosphate determination in seawater are presented. First, the optimal conditions to form the molybdophosphate complex in artificial seawater medium were determined by addition of sulphuric acid and sodium molybdate to the solution containing orthophosphate. Secondly, the anodic oxidation of molybdenum to form molybdate ions and protons was used to create the molybdophosphate complex without addition of any liquid reagents. The molybdophosphate complex is detectable by amperometry with an average precision of 2.2% for the concentration range found in the open ocean and the detection limit is 0.12 μM. Three solutions are proposed to address the silicate interferences issue and one of these methods is used for the natural samples collected in the coastal waters offshore Peru during the Pelagico 1011-12-BIC OLAYA cruise in November-December 2010. Results showed a good precision with an average of 2.5% and a reasonable deviation of the amperometric analysis as compared with colorimetric measurements (4.9%). Copyright © 2011 Elsevier B.V. All rights reserved.

Genetic stability of Rift Valley fever virus MP-12 vaccine during serial passages in culture cells.

PubMed

Lokugamage, Nandadeva; Ikegami, Tetsuro

2017-01-01

Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa which affects both ruminants and humans. RVF causes serious damage to the livestock industry and is also a threat to public health. The Rift Valley fever virus has a segmented negative-stranded RNA genome consisting of Large (L)-, Medium (M)-, and Small (S)-segments. The live-attenuated MP-12 vaccine is immunogenic in livestock and humans, and is conditionally licensed for veterinary use in the U.S. The MP-12 strain encodes 23 mutations (nine amino acid substitutions) and is attenuated through a combination of mutations in the L-, M-, and S-segments. Among them, the M-U795C, M-A3564G, and L-G3104A mutations contribute to viral attenuation through the L- and M-segments. The M-U795C, M-A3564G, L-U533C, and L-G3750A mutations are also independently responsible for temperature-sensitive (ts) phenotype. We hypothesized that a serial passage of the MP-12 vaccine in culture cells causes reversions of the MP-12 genome. The MP-12 vaccine and recombinant rMP12-ΔNSs16/198 were serially passaged 25 times. Droplet digital PCR analysis revealed that the reversion occurred at L-G3750A during passages of MP-12 in Vero or MRC-5 cells. The reversion also occurred at M-A3564G and L-U533C of rMP12-ΔNSs16/198 in Vero cells. Reversion mutations were not found in MP-12 or the variant, rMP12-TOSNSs, in the brains of mice with encephalitis. This study characterized genetic stability of the MP-12 vaccine and the potential risk of reversion mutation at the L-G3750A ts mutation after excessive viral passages in culture cells.

31 CFR 360.12 - Disposition of excess.

Code of Federal Regulations, 2010 CFR

2010-07-01

... STATES SAVINGS BONDS, SERIES I Limitations on Annual Purchases § 360.12 Disposition of excess. If any person at any time has savings bonds issued during any one calendar year in excess of the prescribed...

31 CFR 360.12 - Disposition of excess.

Code of Federal Regulations, 2014 CFR

2014-07-01

... STATES SAVINGS BONDS, SERIES I Limitations on Annual Purchases § 360.12 Disposition of excess. If any person at any time has savings bonds issued during any one calendar year in excess of the prescribed...

31 CFR 353.12 - Disposition of excess.

Code of Federal Regulations, 2013 CFR

2013-07-01

... STATES SAVINGS BONDS, SERIES EE AND HH Limitations on Annual Purchases § 353.12 Disposition of excess. If any person at any time has savings bonds issued during any one calendar year in excess of the...

31 CFR 353.12 - Disposition of excess.

Code of Federal Regulations, 2014 CFR

2014-07-01

... STATES SAVINGS BONDS, SERIES EE AND HH Limitations on Annual Purchases § 353.12 Disposition of excess. If any person at any time has savings bonds issued during any one calendar year in excess of the...

31 CFR 353.12 - Disposition of excess.

Code of Federal Regulations, 2010 CFR

2010-07-01

... STATES SAVINGS BONDS, SERIES EE AND HH Limitations on Annual Purchases § 353.12 Disposition of excess. If any person at any time has savings bonds issued during any one calendar year in excess of the...

31 CFR 360.12 - Disposition of excess.

Code of Federal Regulations, 2013 CFR

2013-07-01

... STATES SAVINGS BONDS, SERIES I Limitations on Annual Purchases § 360.12 Disposition of excess. If any person at any time has savings bonds issued during any one calendar year in excess of the prescribed...

EUV lithography for 22nm half pitch and beyond: exploring resolution, LWR, and sensitivity tradeoffs

NASA Astrophysics Data System (ADS)

Putna, E. Steve; Younkin, Todd R.; Caudillo, Roman; Chandhok, Manish

2010-04-01

The International Technology Roadmap for Semiconductors (ITRS) denotes Extreme Ultraviolet (EUV) lithography as a leading technology option for realizing the 22nm half pitch node and beyond. Readiness of EUV materials is currently one high risk area according to recent assessments made at the 2009 EUVL Symposium. The main development issue regarding EUV resist has been how to simultaneously achieve high sensitivity, high resolution, and low line width roughness (LWR). This paper describes the strategy and current status of EUV resist development at Intel Corporation. Data collected utilizing Intel's Micro-Exposure Tool (MET) is presented in order to examine the feasibility of establishing a resist process that simultaneously exhibits <=22nm half-pitch (HP) L/S resolution at <= 12.5mJ/cm2 with <= 4nm LWR.

77 FR 23709 - Combined Notice of Filings #3

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 3 Take notice... Date: 4/12/12. Accession Number: 20120412-5054. Comments Due: 5 p.m. ET 5/3/12. Docket Numbers: ER12.... Accession Number: 20120412-5081. Comments Due: 5 p.m. ET 5/3/12. Docket Numbers: ER12-1525-000. Applicants...

School-Age NOTES. 1995.

ERIC Educational Resources Information Center

Scofield, Richard T., Ed.

1995-01-01

These 12 newsletter issues supply educational resources to providers of school-age child care. Each eight-page issue may include several feature articles; activities that providers can use with children; descriptions of professional development activities and training programs; information on books, pamphlets, and other educational materials in…

Comparison of the Performance and Capabilities of Femtocell versus Wi-Fi Networks

DTIC Science & Technology

2012-09-01

6  II.  FEMTOCELL HISTORY, ISSUES, AND CHALLENGES ...................................9  A.  A BRIEF HISTORY OF FEMTOCELLS...9  B.  FEMTOCELL ISSUES AND CHALLENGES ...........................................10  1.  Quality of... Challenges .........................................................................12  5.  Regulatory Challenges

Use of a mobile terrestrial laser system to quantify the impact of rigid coastal protective structures on sandy beaches, Quebec, Canada

NASA Astrophysics Data System (ADS)

Van-Wierts, S.; Bernatchez, P.

2012-04-01

Coastal erosion is an important issue within the St-Lawrence estuary and gulf, especially in zones of unconsolidated material. Wide beaches are important coastal environments; they act as a buffer against breaking waves by absorbing and dissipating their energy, thus reducing the rate of coastal erosion. They also offer protection to humans and nearby ecosystems, providing habitat for plants, animals and lifeforms such as algae and microfauna. Conventional methods, such as aerial photograph analysis, fail to adequately quantify the morphosedimentary behavior of beaches at the scale of a hydrosedimentary cells. The lack of reliable and quantitative data leads to considerable errors of overestimation and underestimation of sediment budgets. To address these gaps and to minimize acquisition costs posed by airborne LiDAR survey, a mobile terrestrial LiDAR has been set up to acquire topographic data of the coastal zone. The acquisition system includes a LiDAR sensor, a high precision navigation system (GPS-INS) and a video camera. Comparison of LiDAR data with 1050 DGPS control points shows a vertical mean absolute error of 0.1 m in beach areas. The extracted data is used to calculate sediment volumes, widths, slopes, and a sediment budget index. A high accuracy coastal characterization is achieved through the integration of laser data and video. The main objective of this first project using this system is to quantify the impact of rigid coastal protective structures on sediment budget and beach morphology. Results show that the average sediment volume of beaches located before a rock armour barrier (12 m3/m) were three times narrower than for natural beaches (35,5 m3/m). Natural beaches were also found to have twice the width (25.4 m) of the beaches bordering inhabited areas (12.7 m). The development of sediment budget index for beach areas is an excellent proxy to quickly identify deficit areas and therefore the coastal segments most at risk of erosion. The obtained LiDAR coverage also revealed that beach profiles made at an interval of more than 200 m on diversified coasts lead to results significantly different from reality. However, profile intervals have little impact on long uniform beaches.

Discovery of a Kojibiose Phosphorylase in Escherichia coli K-12.

PubMed

Mukherjee, Keya; Narindoshvili, Tamari; Raushel, Frank M

2018-05-15

The substrate profiles for three uncharacterized enzymes (YcjM, YcjT, and YcjU) that are expressed from a cluster of 12 genes ( ycjM-W and ompG) of unknown function in Escherichia coli K-12 were determined. Through a comprehensive bioinformatic and steady-state kinetic analysis, the catalytic function of YcjT was determined to be kojibiose phosphorylase. In the presence of saturating phosphate and kojibiose (α-(1,2)-d-glucose-d-glucose), this enzyme catalyzes the formation of d-glucose and β-d-glucose-1-phosphate ( k cat = 1.1 s -1 , K m = 1.05 mM, and k cat / K m = 1.12 × 10 3 M -1 s -1 ). Additionally, it was also shown that in the presence of β-d-glucose-1-phosphate, YcjT can catalyze the formation of other disaccharides using 1,5-anhydro-d-glucitol, l-sorbose, d-sorbitol, or l-iditol as a substitute for d-glucose. Kojibiose is a component of cell wall lipoteichoic acids in Gram-positive bacteria and is of interest as a potential low-calorie sweetener and prebiotic. YcjU was determined to be a β-phosphoglucomutase that catalyzes the isomerization of β-d-glucose-1-phosphate ( k cat = 21 s -1 , K m = 18 μM, and k cat / K m = 1.1 × 10 6 M -1 s -1 ) to d-glucose-6-phosphate. YcjU was also shown to exhibit catalytic activity with β-d-allose-1-phosphate, β-d-mannose-1-phosphate, and β-d-galactose-1-phosphate. YcjM catalyzes the phosphorolysis of α-(1,2)-d-glucose-d-glycerate with a k cat = 2.1 s -1 , K m = 69 μM, and k cat / K m = 3.1 × 10 4 M -1 s -1 .

Anesthetics inhibit extracellular signal-regulated Kinase1/2 phosphorylation via NMDA receptor, phospholipase C and protein kinase C in mouse hippocampal slices.

PubMed

Haiying, Gao; Mingjie, Han; Lingyu, Zhang; Qingxiang, Wang; Haisong, Wang; Bingxi, Zhang

2017-02-01

Extracellular signal-regulated kinase 1/2 (ERK1/2) has been implicated in learning and memory; however, whether intravenous anesthetics modulate ERK1/2 remains unknown. The aim of this study was to examine the effect of several intravenous anesthetics on the phosphorylation of ERK1/2 in the hippocampus of adult mice. Western blotting was used to examine cellular levels of phosphorylated and unphosphorylated ERK1/2 in mouse hippocampus slices, which were incubated with or without anesthetics including propofol, etomidate, ketamine and midazolam, a protein kinase C (PKC) activator or inhibitor, or phospholipase C (PLC) activator or inhibitor. Propofol, etomidate, ketamine and midazolam reduced phosphorylation of ERK1/2 in a time-dependent manner. Washing out propofol after 5 min increased ERK1/2 phosphorylation. The anesthetic-induced depression of ERK1/2 phosphorylation was blocked by 0.1 μM phorbol-12-myristate 13-acetate (an activator of PKC), 50 μM U73122 (an inhibitor of PLC). The anesthetic-induced depression of ERK1 phosphorylation was blocked by 1 mMN-methyl-d-aspartate (NMDA). Whereas 100 μM chelerythrine (an inhibitor of PKC) and 100 μM carbachol (an activator of PLC) and 20 μM PD-98059 (an inhibitor of MEK) had additive effects on propofol-induced inhibition of ERK1/2 phosphorylation. In contrast, 10 μM MK801 (a NMDA receptor antagonist) did not block anesthetic-induced inhibition of ERK1/2 phosphorylation. Intravenous anesthetics markedly decreased phosphorylation of ERK1/2 in mouse hippocampal slices, most likely via the NMDA receptor, and PLC- and PKC-dependent pathways. Thus, ERK1/2 represents a target for anesthetics in the brain. Copyright © 2016. Published by Elsevier Ltd.

CT image biomarkers to improve patient-specific prediction of radiation-induced xerostomia and sticky saliva.

PubMed

van Dijk, Lisanne V; Brouwer, Charlotte L; van der Schaaf, Arjen; Burgerhof, Johannes G M; Beukinga, Roelof J; Langendijk, Johannes A; Sijtsema, Nanna M; Steenbakkers, Roel J H M

2017-02-01

Current models for the prediction of late patient-rated moderate-to-severe xerostomia (XER 12m ) and sticky saliva (STIC 12m ) after radiotherapy are based on dose-volume parameters and baseline xerostomia (XER base ) or sticky saliva (STIC base ) scores. The purpose is to improve prediction of XER 12m and STIC 12m with patient-specific characteristics, based on CT image biomarkers (IBMs). Planning CT-scans and patient-rated outcome measures were prospectively collected for 249 head and neck cancer patients treated with definitive radiotherapy with or without systemic treatment. The potential IBMs represent geometric, CT intensity and textural characteristics of the parotid and submandibular glands. Lasso regularisation was used to create multivariable logistic regression models, which were internally validated by bootstrapping. The prediction of XER 12m could be improved significantly by adding the IBM "Short Run Emphasis" (SRE), which quantifies heterogeneity of parotid tissue, to a model with mean contra-lateral parotid gland dose and XER base . For STIC 12m , the IBM maximum CT intensity of the submandibular gland was selected in addition to STIC base and mean dose to submandibular glands. Prediction of XER 12m and STIC 12m was improved by including IBMs representing heterogeneity and density of the salivary glands, respectively. These IBMs could guide additional research to the patient-specific response of healthy tissue to radiation dose. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Inadequate protein intake after laparoscopic sleeve gastrectomy surgery is associated with a greater fat free mass loss.

PubMed

Sherf Dagan, Shiri; Tovim, Tali Ben; Keidar, Andrei; Raziel, Asnat; Shibolet, Oren; Zelber-Sagi, Shira

2017-01-01

Low postoperative protein intake may represent a modifiable risk factor that leads to fat free mass (FFM) loss postlaparoscopic sleeve gastrectomy (LSG), but data concerning this phenomenon is scarce. To evaluate the association between daily protein intake and relative FFM loss at 6 (M6) and 12 (M12) months after LSG surgery. Private hospital and university hospital. A prospective cohort study with 12 months follow-up of 77 patients who underwent LSG surgery. Anthropometrics including body composition analysis measured by multifrequency bioelectrical impedance analysis, 3-day food diaries, food intolerance, and habitual physical activity were evaluated at baseline and at M3, M6, and M12. Repeated body composition measurements and food diary were available for 77 patients (45 women) at M6 and for 68 patients at M12. Mean age was 42.7±9.4 years and mean preoperative body mass index was 42.2±4.8 kg/m 2 . A protein intake of≥60 g/d was achieved in 13.3%, 32.5% and 39.7% of the study participants at M3, M6 and M12, respectively. FFM significantly decreased at M6 and stabilized at M12. Protein intake of≥60 g/d was associated with a significantly lower relative FFM loss at M6 among women (8.9±6.5% versus 12.4±4.1%; P = .039) and this trend was also reported among men (9.5±5.5% versus 13.4±6.0%; P = .068). A logistic regression for the prediction of FFM loss of≥10% at M6, indicated that protein intake≥60 g/d is a strong protective factor (odds ratio = 0.29, 95% confidence interval .09-.96, P = .043). Our study supports the currently recommended protein intake goal of≥60 g/d as an efficient strategy for better preservation of FFM post-LSG. Copyright © 2017 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.