Sample records for einsteinium 243

  1. Einsteinium

    NASA Astrophysics Data System (ADS)

    Haire, Richard G.

    The discovery of einsteinium, element 99, came about during the analyses of nuclear products produced in and then recovered from test debris following a thermonuclear explosion (weapon test device, ‘Mike', November 1952) at Eniwetok Atoll in the Pacific Ocean. The uranium present in this device was subjected to a very intense neutron flux (integrated fluence of about 1024neutrons) in an extremely short time frame (few nanoseconds), which allowed a large number of multiple neutron captures with a minimal degree of decay of the products formed. Nuclei were formed with usually high neutron/proton ratios (very ‘heavy' uranium isotopes), which then rapidly beta-decayed into new, transuranium isotopes through element 100. Scientists from several U.S. Government laboratories separated and analyzed extensively the debris samplings in the following weeks. From these investigations came the discovery and identification of einsteinium and fermium. The first element was named in honor of Albert Einstein, and assigned the symbol, E (later changed to the current symbol, Es). Additional details and discussions about the discovery of this element and the scientists involved are given in several references (Thompson et al., 1954; Ghiorso et al., 1955; Fields et al., 1956; Hyde et al., 1964; Seaborg and Loveland, 1990).

  2. Chemical Properties of Elements 99 and 100 [Einsteinium and Fermium

    DOE R&D Accomplishments Database

    Seaborg, G. T.; Thompson, S. G.; Harvey, B. G.; Choppin, G. R.

    1954-07-23

    A description of some of the chemical properties and of the methods used in the separations of elements 99 [Einsteinium] and 100 [Fermium] are given. The new elements exhibit the properties expected for the tenth and eleventh actinide elements. Attempts to produce an oxidation state greater than III of element 99 have been unsuccessful. In normal aqueous media only the III state of element 100 appears to exist. The relative spacings of the elution peaks of the new elements in some separations with ion exchange resin columns are the same as the relative spacings of the homologous lanthanide elements. The results of experiments involving cation exchange resins with very concentrated hydrochloric acid eluant show that the new elements, like the earlier actinides, are more strongly complexed than the lanthanides. The new elements also exist partially as anions in concentrated hydrochloric acid, as do earlier actinide elements, and they may be partially separated from each other by means of ion exchange resins. With some eluants interesting reversals of elution positions are observed in the region Bk-Cf-99-100, indicating complex ion formation involving unusual factors.

  3. BAG PASSOUT SEALER FOR WATER-SHIELDED CAVE FACILITY (Engineering Materials)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1963-10-31

    The water-shielded cave facility is used in processing irradiated slugs for recovery of americium, curium, berkelium, californium, einsteinium, and fermium. The remotely operated, plastic-bag passout sealer is used in removing isotopic fractions for storage in the rear or for removing radioactive waste for placement in the waste storage containers. The unit is accessible by both the primary inclosure master-slaves and the service area master-slaves. (F.L.S.)

  4. Handbook of Basic Atomic Spectroscopic Data

    National Institute of Standards and Technology Data Gateway

    SRD 108 Handbook of Basic Atomic Spectroscopic Data (Web, free access)   This handbook provides a selection of the most important and frequently used atomic spectroscopic data. The compilation includes data for the neutral and singly-ionized atoms of all elements hydrogen through einsteinium (Z = 1-99). The wavelengths, intensities, and spectrum assignments are given for each element, and the data for the approximately 12,000 lines of all elements are also collected into a single table.

  5. Systematization of actinides using cluster analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kopyrin, A.A.; Terent`eva, T.N.; Khramov, N.N.

    1994-11-01

    A representation of the actinides in multidimensional property space is proposed for systematization of these elements using cluster analysis. Literature data for their atomic properties are used. Owing to the wide variation of published ionization potentials, medians are used to estimate them. Vertical dendograms are used for classification on the basis of distances between the actinides in atomic-property space. The properties of actinium and lawrencium are furthest removed from the main group. Thorium and mendelevium exhibit individualized properties. A cluster based on the einsteinium-fermium pair is joined by californium.

  6. Nuclear Data Sheets for A=243

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nesaraja, Caroline D; McCutchan, Elizabeth A.

    2014-09-30

    We present available information pertaining to the nuclear structure of all nuclei with mass numbers A=243. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ( 243Np, 243Pu, 243Am, 243Cm, 243Bk, and 243Cf), 2011Me01 ( 243Es), and 2013Th02 ( 243Fm).

  7. 48 CFR 243.204-70-5 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-5 Exceptions. (a) The limitations in 243.204-70-2, 243.204-70-3, and 243.204-70-4 do not apply to unpriced change orders... change orders for ship construction and ship repair. (c) The head of the agency may waive the limitations...

  8. 48 CFR 243.204-70-5 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-5 Exceptions. (a) The limitations in 243.204-70-2, 243.204-70-3, and 243.204-70-4 do not apply to unpriced change orders... change orders for ship construction and ship repair. (c) The head of the agency may waive the limitations...

  9. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.201 Safety. ...

  10. 40 CFR 243.201 - Safety.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Safety. 243.201 Section 243.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.201 Safety. ...

  11. 40 CFR 243.200 - Storage.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Storage. 243.200 Section 243.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.200 Storage. ...

  12. 40 CFR 243.200 - Storage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Storage. 243.200 Section 243.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.200 Storage. ...

  13. 40 CFR 243.200 - Storage.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Storage. 243.200 Section 243.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.200 Storage. ...

  14. 40 CFR 243.200 - Storage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Storage. 243.200 Section 243.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.200 Storage. ...

  15. 40 CFR 243.200 - Storage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Storage. 243.200 Section 243.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE... Procedures § 243.200 Storage. ...

  16. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management. ...

  17. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management. ...

  18. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management. ...

  19. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management. ...

  20. 40 CFR 243.204 - Collection management.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management. ...

  1. Determination of 243Am by pulse shape discrimination liquid scintillation spectrometry.

    PubMed

    Alamelu, D; Bhade, S P D; Reddy, P J; Narayan, K K; Shah, P M; Aggarwal, S K

    2006-05-01

    Alpha specific activity of 243Am was determined using pulse shape discrimination in liquid scintillation spectrometry. 238Pu, 36Cl and 239Np (purified from 243Am) were used for obtaining the spillover of alpha/beta particles into the beta/alpha channels, respectively. Synthetic mixtures of 241Am/243Am were prepared. Using the alpha-specific activity, weights of the stock solutions used and the half-life of 241Am and 243Am isotopes, the expected 241Am/243Am atom ratios in the mixtures were determined and compared with those obtained by thermal ionization mass spectrometry (TIMS). An agreement of about 1% was obtained between the 241Am/243Am atom ratios determined by the two methods. This shows that liquid scintillation counting with pulse shape discrimination can be used for 243Am determination with an accuracy better than 1%.

  2. 48 CFR 243.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 243.205 Section 243.205 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205 Contract clauses. ...

  3. 48 CFR 243.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clauses. 243.205 Section 243.205 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205 Contract clauses. ...

  4. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders. [75 FR 48277, Aug. 10, 2010] ...

  5. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Scope. 243.100 Section 243.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100...

  6. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Scope. 243.100 Section 243.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100...

  7. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Scope. 243.100 Section 243.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100...

  8. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders. [75 FR 48277, Aug. 10, 2010] ...

  9. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders. [75 FR 48277, Aug. 10, 2010] ...

  10. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders. [75 FR 48277, Aug. 10, 2010] ...

  11. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders. [75 FR 48277, Aug. 10, 2010] ...

  12. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the Managing...

  13. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the Managing...

  14. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the Managing...

  15. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the Managing...

  16. 14 CFR 243.11 - Transmission of information after an aviation disaster.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... aviation disaster. 243.11 Section 243.11 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.11 Transmission of information after an aviation disaster. (a) Each covered airline shall inform the Managing...

  17. 48 CFR 243.205-71 - Requests for equitable adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Requests for equitable adjustment. 243.205-71 Section 243.205-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-71...

  18. 47 CFR 24.3 - Permissible communications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES General Information § 24.3 Permissible communications. PCS licensees may provide any mobile... mobile operations. Broadcasting as defined in the Communications Act is prohibited. [61 FR 45356, Aug. 29... 47 Telecommunication 2 2010-10-01 2010-10-01 false Permissible communications. 24.3 Section 24.3...

  19. 48 CFR 243.205-71 - Requests for equitable adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Requests for equitable adjustment. 243.205-71 Section 243.205-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-71...

  20. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-70...

  1. 40 CFR 243.203-1 - Requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 243.203-1 Section 243.203... THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.203-1 Requirement. Solid wastes (or materials which have been separated for the...

  2. 40 CFR 243.204-1 - Requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 243.204-1 Section 243.204... THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.204-1 Requirement. The collection of solid wastes (or materials which have been...

  3. 40 CFR 243.204-1 - Requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 243.204-1 Section 243.204... THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.204-1 Requirement. The collection of solid wastes (or materials which have been...

  4. 40 CFR 243.203-1 - Requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 243.203-1 Section 243.203... THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.203-1 Requirement. Solid wastes (or materials which have been separated for the...

  5. 40 CFR 243.203-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 243.203-1 Section 243.203... THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.203-1 Requirement. Solid wastes (or materials which have been separated for the...

  6. 40 CFR 243.204-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 243.204-1 Section 243.204... THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Requirements and Recommended Procedures § 243.204-1 Requirement. The collection of solid wastes (or materials which have been...

  7. 28 CFR 2.43 - Early termination.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Early termination. 2.43 Section 2.43..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.43 Early... shall also conduct a status review whenever the supervision officer recommends early termination of the...

  8. 28 CFR 2.43 - Early termination.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Early termination. 2.43 Section 2.43..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.43 Early... shall also conduct a status review whenever the supervision officer recommends early termination of the...

  9. 28 CFR 2.43 - Early termination.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Early termination. 2.43 Section 2.43..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.43 Early... shall also conduct a status review whenever the supervision officer recommends early termination of the...

  10. 49 CFR 192.243 - Nondestructive testing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Nondestructive testing. 192.243 Section 192.243... BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Welding of Steel in Pipelines § 192.243 Nondestructive testing. (a) Nondestructive testing of welds must be performed by any process, other than trepanning, that...

  11. 48 CFR 243.204-70-4 - Limitations on obligations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Limitations on obligations. 243.204-70-4 Section 243.204-70-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70...

  12. 48 CFR 243.205-70 - Pricing of contract modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing of contract modifications. 243.205-70 Section 243.205-70 Federal Acquisition Regulations System DEFENSE ACQUISITION... Pricing of contract modifications. Use the clause at 252.243-7001, Pricing of Contract Modifications, in...

  13. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service for...

  14. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service for...

  15. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service for...

  16. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service for...

  17. 46 CFR 169.243 - Electrical.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Electrical. 169.243 Section 169.243 Shipping COAST GUARD... Certification Inspections § 169.243 Electrical. At each inspection for certification and periodic inspection... that they are in proper operating condition, in safe electrical condition, and fit for the service for...

  18. 28 CFR 2.43 - Early termination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Early termination. 2.43 Section 2.43..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.43 Early... shall also conduct a status review whenever the supervision officer recommends early termination of the...

  19. 28 CFR 2.43 - Early termination.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Early termination. 2.43 Section 2.43..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.43 Early... shall also conduct a status review whenever the supervision officer recommends early termination of the...

  20. 48 CFR 243.204-70-4 - Limitations on obligations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Limitations on obligations. 243.204-70-4 Section 243.204-70-4 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70...

  1. 47 CFR 90.243 - Mobile relay stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Mobile relay stations. 90.243 Section 90.243... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.243 Mobile relay stations. (a) Mobile relay operations will be authorized on frequencies below 512 MHz, except in the Radiolocation...

  2. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3 Public welfare investments. A national bank or national bank subsidiary may make an investment directly or...

  3. 12 CFR 24.3 - Public welfare investments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Public welfare investments. 24.3 Section 24.3... DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.3 Public welfare investments. A national bank or national bank subsidiary may make an investment directly or...

  4. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false General jurisdictional principles. 24.3 Section 24.3 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In...

  5. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board to...

  6. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board to...

  7. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board to...

  8. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board to...

  9. 42 CFR 24.3 - Policy Board.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Policy Board. 24.3 Section 24.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.3 Policy Board. The Secretary or his/her designee shall establish an SBRS Policy Board to...

  10. 7 CFR 58.243 - Checking quality.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Checking quality. 58.243 Section 58.243 Agriculture... Procedures § 58.243 Checking quality. All milk, milk products and dry milk products shall be subject to inspection and analysis by the dairy plant for quality and condition throughout each processing operation...

  11. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are subject...

  12. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are subject...

  13. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are subject...

  14. 20 CFR 243.4 - Taxation of benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Taxation of benefits. 243.4 Section 243.4 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.4 Taxation of benefits. (a) Annuities paid by the Board are subject...

  15. 45 CFR 158.243 - De minimis rebates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false De minimis rebates. 158.243 Section 158.243 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS Calculating and Providing the Rebate § 158.243 De...

  16. 48 CFR 243.170 - Identification of foreign military sale (FMS) requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Identification of foreign military sale (FMS) requirements. 243.170 Section 243.170 Federal Acquisition Regulations System DEFENSE....170 Identification of foreign military sale (FMS) requirements. Follow the procedures at PGI 243.170...

  17. 47 CFR 15.243 - Operation in the band 890-940 MHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation in the band 890-940 MHz. 15.243 Section 15.243 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.243 Operation in the band 890-940...

  18. 5 CFR 591.243 - How many members are on each COLA Advisory Committee?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false How many members are on each COLA Advisory Committee? 591.243 Section 591.243 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... Areas Program Administration § 591.243 How many members are on each COLA Advisory Committee? A COLA...

  19. 5 CFR 591.243 - How many members are on each COLA Advisory Committee?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false How many members are on each COLA Advisory Committee? 591.243 Section 591.243 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... Areas Program Administration § 591.243 How many members are on each COLA Advisory Committee? A COLA...

  20. 5 CFR 591.243 - How many members are on each COLA Advisory Committee?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false How many members are on each COLA Advisory Committee? 591.243 Section 591.243 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... Areas Program Administration § 591.243 How many members are on each COLA Advisory Committee? A COLA...

  1. 5 CFR 591.243 - How many members are on each COLA Advisory Committee?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false How many members are on each COLA Advisory Committee? 591.243 Section 591.243 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... Areas Program Administration § 591.243 How many members are on each COLA Advisory Committee? A COLA...

  2. 5 CFR 591.243 - How many members are on each COLA Advisory Committee?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false How many members are on each COLA Advisory Committee? 591.243 Section 591.243 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... Areas Program Administration § 591.243 How many members are on each COLA Advisory Committee? A COLA...

  3. 30 CFR 243.202 - When will MMS monitor my financial solvency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When will MMS monitor my financial solvency? 243.202 Section 243.202 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Financial Solvency Requirements § 243.202 When will MMS...

  4. 20 CFR 243.6 - Waiver of annuity payments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Waiver of annuity payments. 243.6 Section 243... TRANSFER, ASSIGNMENT, OR WAIVER OF PAYMENTS § 243.6 Waiver of annuity payments. (a) Any individual who has been awarded an annuity under the Railroad Retirement Act shall have the right to waive such annuity in...

  5. 30 CFR 243.100 - What standards must my MMS-specified surety instrument meet?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... instrument meet? 243.100 Section 243.100 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Bonding Requirements § 243.100 What standards must my MMS-specified surety instrument meet? (a) An MMS-specified surety instrument must be in a form specified in MMS instructions. MMS will give you written...

  6. 19 CFR 24.3 - Bills and accounts; receipts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Bills and accounts; receipts. 24.3 Section 24.3... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.3 Bills and accounts; receipts. (a) Any bill or... document filed by the payer and the payer's cancelled check shall constitute evidence of payment. (c) A...

  7. 19 CFR 24.3 - Bills and accounts; receipts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Bills and accounts; receipts. 24.3 Section 24.3... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.3 Bills and accounts; receipts. (a) Any bill or... document filed by the payer and the payer's cancelled check shall constitute evidence of payment. (c) A...

  8. 19 CFR 24.3 - Bills and accounts; receipts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Bills and accounts; receipts. 24.3 Section 24.3... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.3 Bills and accounts; receipts. (a) Any bill or... document filed by the payer and the payer's cancelled check shall constitute evidence of payment. (c) A...

  9. 19 CFR 24.3 - Bills and accounts; receipts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Bills and accounts; receipts. 24.3 Section 24.3... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.3 Bills and accounts; receipts. (a) Any bill or... document filed by the payer and the payer's cancelled check shall constitute evidence of payment. (c) A...

  10. 19 CFR 24.3 - Bills and accounts; receipts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Bills and accounts; receipts. 24.3 Section 24.3... TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.3 Bills and accounts; receipts. (a) Any bill or... document filed by the payer and the payer's cancelled check shall constitute evidence of payment. (c) A...

  11. 48 CFR 243.204-70-7 - Plans and reports.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Plans and reports. 243.204-70-7 Section 243.204-70-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-7 Plans and reports. To provide for enhanced...

  12. 48 CFR 243.204-70-7 - Plans and reports.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Plans and reports. 243.204-70-7 Section 243.204-70-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-7 Plans and reports. To provide for enhanced...

  13. 48 CFR 1843.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 1843.205 Contract clauses. As authorized in the prefaces of clauses FAR 52.243-1, Changes—Fixed Price; FAR 52.243-2, Changes—Cost Reimbursement; and FAR 52.243-4, Changes; and in the prescription at 43.205(c) for FAR 52.243-3, Changes—Time-and-Material or...

  14. 30 CFR 243.201 - How will MMS determine if I am financially solvent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section by one of the methods in § 243.200(a): (1) A written request asking us to consult a business... active appeals. (d) If you request that we consult a business-information or credit-reporting service or... solvent? 243.201 Section 243.201 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  15. 48 CFR 52.243-3 - Changes-Time-and-Materials or Labor-Hours.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... performed. (2) Time of performance (i.e., hours of the day, days of the week, etc.). (3) Place of... or Labor-Hours. 52.243-3 Section 52.243-3 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.243-3 Changes—Time-and-Materials or Labor-Hours. As prescribed in 43.205(c), insert the...

  16. 75 FR 3420 - Airworthiness Directives; Airbus Model A330-201, -202, -203, -223, -243, -301, -302, -303, -321...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...-201, -202, -203, - 223, -243, -301, -302, -303, -321, -322, -323, -341, -342, and -343 Airplanes...-201, -202, -203, -223, -243, -301, -302, -303, -321, -322, -323, - 341, -342, and -343 airplanes... through 270714 inclusive. (1) Model A330-201, -202, -203, -223, -243, -301, -302, -303, - 321, -322, -323...

  17. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Interim approval of the Carbon Monoxide plan for the South Coast. 52.243 Section 52.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.243 Interim approval of the Carbon...

  18. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Interim approval of the Carbon Monoxide plan for the South Coast. 52.243 Section 52.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.243 Interim approval of the Carbon...

  19. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Interim approval of the Carbon Monoxide plan for the South Coast. 52.243 Section 52.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.243 Interim approval of the Carbon...

  20. 40 CFR 52.243 - Interim approval of the Carbon Monoxide plan for the South Coast.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false Interim approval of the Carbon Monoxide plan for the South Coast. 52.243 Section 52.243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.243 Interim approval of the Carbon...

  1. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision, guarantees...

  2. 40 CFR 61.243-2 - Alternative standards for valves in VHAP service-skip period leak detection and repair.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VHAP service-skip period leak detection and repair. 61.243-2 Section 61.243-2 Protection of Environment... AIR POLLUTANTS National Emission Standard for Equipment Leaks (Fugitive Emission Sources) § 61.243-2 Alternative standards for valves in VHAP service—skip period leak detection and repair. (a)(1) An owner or...

  3. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision, guarantees...

  4. 20 CFR 243.5 - Assignment of a portion of an annuity paid under the social security overall minimum provision.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under the social security overall minimum provision. 243.5 Section 243.5 Employees' Benefits RAILROAD... § 243.5 Assignment of a portion of an annuity paid under the social security overall minimum provision. Section 3(f)(3) of the Railroad Retirement Act, the social security overall minimum provision, guarantees...

  5. 30 CFR 243.6 - When must I or another person meet the bonding or financial solvency requirements under this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or financial solvency requirements under this part? 243.6 Section 243.6 Mineral Resources MINERALS... bonding or financial solvency requirements under this part? If you must meet the bonding or financial solvency requirements under § 243.4(a)(1), or if another person is meeting your bonding or financial...

  6. Functional annotation of the genome unravels probiotic potential of Bacillus coagulans HS243.

    PubMed

    Kapse, N G; Engineer, A S; Gowdaman, V; Wagh, S; Dhakephalkar, P K

    2018-05-30

    Spore forming Bacillus species are widely used as probiotics for human dietary supplements and in animal feeds. However, information on genetic basis of their probiotic action is obscure. Therefore, the present investigation was undertaken to elucidate probiotic traits of B. coagulans HS243 through its genome analysis. Genome mining revealed the presence of an arsenal of marker genes attributed to genuine probiotic traits. In silico analysis of HS243 genome revealed the presence of multi subunit ATPases, ADI pathway genes, chologlycine hydrolase, adhesion proteins for surviving and colonizing harsh gastric transit. HS243 genome harbored vitamin and essential amino acid biosynthetic genes, suggesting the use of HS243 as a nutrient supplement. Bacteriocin producing genes highlighted the disease preventing potential of HS243. Thus, this work established that HS243 possessed the genetic repertoire required for surviving harsh gastric transit and conferring health benefits to the host which were further validated by wet lab evidences. Copyright © 2018. Published by Elsevier Inc.

  7. Finding a Depression App: A Review and Content Analysis of the Depression App Marketplace

    PubMed Central

    Shen, Nelson; Levitan, Michael-Jane; Johnson, Andrew; Bender, Jacqueline Lorene; Hamilton-Page, Michelle; Jadad, Alejandro (Alex) R

    2015-01-01

    Background Depression is highly prevalent and causes considerable suffering and disease burden despite the existence of wide-ranging treatment options. Mobile phone apps offer the potential to help close this treatment gap by confronting key barriers to accessing support for depression. Objectives Our goal was to identify and characterize the different types of mobile phone depression apps available in the marketplace. Methods A search for depression apps was conducted on the app stores of the five major mobile phone platforms: Android, iPhone, BlackBerry, Nokia, and Windows. Apps were included if they focused on depression and were available to people who self-identify as having depression. Data were extracted from the app descriptions found in the app stores. Results Of the 1054 apps identified by the search strategy, nearly one-quarter (23.0%, 243/1054) unique depression apps met the inclusion criteria. Over one-quarter (27.7%, 210/758) of the excluded apps failed to mention depression in the title or description. Two-thirds of the apps had as their main purpose providing therapeutic treatment (33.7%, 82/243) or psychoeducation (32.1%, 78/243). The other main purpose categories were medical assessment (16.9%, 41/243), symptom management (8.2%, 20/243), and supportive resources (1.6%, 4/243). A majority of the apps failed to sufficiently describe their organizational affiliation (65.0%, 158/243) and content source (61.7%, 150/243). There was a significant relationship (χ 2 5=50.5, P<.001) between the main purpose of the app and the reporting of content source, with most medical assessment apps reporting their content source (80.5%, 33/41). A fifth of the apps featured an e-book (20.6%, 50/243), audio therapy (16.9%, 41/243), or screening (16.9%, 41/243) function. Most apps had a dynamic user interface (72.4%, 176/243) and used text as the main type of media (51.9%, 126/243), and over a third (14.4%, 35/243) incorporated more than one form of media. Conclusion Without guidance, finding an appropriate depression app may be challenging, as the search results yielded non-depression–specific apps to depression apps at a 3:1 ratio. Inadequate reporting of organization affiliation and content source increases the difficulty of assessing the credibility and reliability of the app. While certification and vetting initiatives are underway, this study demonstrates the need for standardized reporting in app stores to help consumers select appropriate tools, particularly among those classified as medical devices. PMID:25689790

  8. Finding a depression app: a review and content analysis of the depression app marketplace.

    PubMed

    Shen, Nelson; Levitan, Michael-Jane; Johnson, Andrew; Bender, Jacqueline Lorene; Hamilton-Page, Michelle; Jadad, Alejandro Alex R; Wiljer, David

    2015-02-16

    Depression is highly prevalent and causes considerable suffering and disease burden despite the existence of wide-ranging treatment options. Mobile phone apps offer the potential to help close this treatment gap by confronting key barriers to accessing support for depression. Our goal was to identify and characterize the different types of mobile phone depression apps available in the marketplace. A search for depression apps was conducted on the app stores of the five major mobile phone platforms: Android, iPhone, BlackBerry, Nokia, and Windows. Apps were included if they focused on depression and were available to people who self-identify as having depression. Data were extracted from the app descriptions found in the app stores. Of the 1054 apps identified by the search strategy, nearly one-quarter (23.0%, 243/1054) unique depression apps met the inclusion criteria. Over one-quarter (27.7%, 210/758) of the excluded apps failed to mention depression in the title or description. Two-thirds of the apps had as their main purpose providing therapeutic treatment (33.7%, 82/243) or psychoeducation (32.1%, 78/243). The other main purpose categories were medical assessment (16.9%, 41/243), symptom management (8.2%, 20/243), and supportive resources (1.6%, 4/243). A majority of the apps failed to sufficiently describe their organizational affiliation (65.0%, 158/243) and content source (61.7%, 150/243). There was a significant relationship (χ(2) 5=50.5, P<.001) between the main purpose of the app and the reporting of content source, with most medical assessment apps reporting their content source (80.5%, 33/41). A fifth of the apps featured an e-book (20.6%, 50/243), audio therapy (16.9%, 41/243), or screening (16.9%, 41/243) function. Most apps had a dynamic user interface (72.4%, 176/243) and used text as the main type of media (51.9%, 126/243), and over a third (14.4%, 35/243) incorporated more than one form of media. Without guidance, finding an appropriate depression app may be challenging, as the search results yielded non-depression-specific apps to depression apps at a 3:1 ratio. Inadequate reporting of organization affiliation and content source increases the difficulty of assessing the credibility and reliability of the app. While certification and vetting initiatives are underway, this study demonstrates the need for standardized reporting in app stores to help consumers select appropriate tools, particularly among those classified as medical devices.

  9. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who can own imported reindeer, and what limitations apply? 243.5 Section 243.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.5 Who can own imported reindeer, and what limitations apply? (a) Anyone, including non-Natives, may own imported reindeer i...

  10. 25 CFR 243.7 - How can a non-Native acquire live reindeer?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How can a non-Native acquire live reindeer? 243.7 Section 243.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.7 How can a non-Native acquire live reindeer? If you are a non-Native who wants to acquire live Alaskan reindeer, you must apply to us in...

  11. 25 CFR 243.12 - Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Are Alaska reindeer trust assets maintained by the U.S. Government for the benefit of Alaska Natives? 243.12 Section 243.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE REINDEER IN ALASKA § 243.12 Are Alaska reindeer trust assets maintained by the U.S. Government for the...

  12. ESO 243-49 HLX-1: scaling of X-ray spectral properties and black hole mass determination

    NASA Astrophysics Data System (ADS)

    Titarchuk, Lev; Seifina, Elena

    2016-11-01

    We report the results of Swift/XRT observations (2008-2015) of a hyper-luminous X-ray source, ESO 243-49 HLX-1. We demonstrate a strong observational evidence that ESO 243-49 HLX-1 undergoes spectral transitions from the low/hard state to the high/soft state during these observations. The spectra of ESO 243-49 HLX-1 are well fitted by the so-called bulk motion Comptonization model for all spectral states. We have established the photon index (Γ) saturation level, Γsat = 3.0 ± 0.1, in the Γ versus mass accretion rate (Ṁ) correlation. This Γ-Ṁ correlation allows us to estimate black hole (BH) mass in ESO 243-49 HLX-1 to be MBH 7 × 104 M⊙ assuming the distance to ESO 243-49 of 95 Mpc. For the BH mass estimate we use the scaling method taking Galactic BHs XTE J1550-564, H 1743-322 and 4U 1630-472, and an extragalactic BH source, M101 ULX-1 as reference sources. The Γ versus Ṁ correlation revealed in ESO 243-49 HLX-1 is similar to those in a number of Galactic and extragalactic BHs and it clearly shows the correlation along with the strong Γ saturation at ≈3. This is a robust observational evidence for the presence of a BH in ESO 243-49 HLX-1. We also find that the seed (disk) photon temperatures are quite low, of order of 50-140 eV which are consistent with high BH mass in ESO 243-49 HLX-1.

  13. 40 CFR 243.201-1 - Requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... protect the health and safety of personnel associated with the operation. ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 243.201-1 Section 243.201-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

  14. 40 CFR 243.201-1 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... protect the health and safety of personnel associated with the operation. ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 243.201-1 Section 243.201-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

  15. 40 CFR 243.201-1 - Requirement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... protect the health and safety of personnel associated with the operation. ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirement. 243.201-1 Section 243.201-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

  16. 40 CFR 243.201-1 - Requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... protect the health and safety of personnel associated with the operation. ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 243.201-1 Section 243.201-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

  17. 40 CFR 243.201-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... protect the health and safety of personnel associated with the operation. ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 243.201-1 Section 243.201-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

  18. 40 CFR Appendix to Part 243 - Recommended Bibliography

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Part 243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE Pt. 243, App... guide in solid waste management. Environmental Protection Publication SW-127. Washington, U.S...

  19. miR-24-3p Suppresses Malignant Behavior of Lacrimal Adenoid Cystic Carcinoma by Targeting PRKCH to Regulate p53/p21 Pathway.

    PubMed

    Zhang, Ming-Xue; Zhang, Jie; Zhang, Hong; Tang, Hua

    2016-01-01

    MicroRNA (miRNA) may function as an oncogene or a tumor suppressor in tumorigenesis. However, the mechanism of miRNAs in adenoid cystic carcinoma (ACC) is unclear. Here, we provide evidence that miR-24-3p was downreglated and functions as a tumor suppressor in human lacrimal adenoid cystic carcinoma by suppressing proliferation and migration/invasion while promoting apoptosis. miR-24-3p down-regulated protein kinase C eta (PRKCH) by binding to its untranslated region (3'UTR). PRKCH increased the of the cell growth and migration/invasion in ACC cells and suppressed the expression of p53 and p21 in both mRNA and protein level. The overexpression of miR-24-3p decreased its malignant phenotype. Ectopic expression of PRKCH counteracted the suppression of malignancy induced by miR-24-3p, as well as ectopic expression of miR-24-3p rescued the suppression of PRKCH in the p53/p21 pathway. These results suggest that miR-24-3p promotes the p53/p21 pathway by down-regulating PRKCH expression in lacrimal adenoid cystic carcinoma cells.

  20. 48 CFR 1652.243-70 - Changes-Negotiated benefits contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Changes-Negotiated benefits contracts. 1652.243-70 Section 1652.243-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CLAUSES AND FORMS CONTRACT...

  1. 40 CFR 243.201-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... equipment should meet the applicable provisions of the Occupational Safety and Health Administration... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommended procedures: Operations. 243.201-2 Section 243.201-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

  2. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommended procedures: Operations. 243.202-3 Section 243.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... receive periodic vehicle safety checks, including, but not limited to, inspection of brakes, windshield...

  3. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Operations. 243.202-3 Section 243.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... receive periodic vehicle safety checks, including, but not limited to, inspection of brakes, windshield...

  4. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Operations. 243.202-3 Section 243.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... receive periodic vehicle safety checks, including, but not limited to, inspection of brakes, windshield...

  5. 40 CFR 243.203-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) The minimum collection frequency consistent with public health and safety should be adopted to... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommended procedures: Operations. 243.203-2 Section 243.203-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

  6. 40 CFR 243.203-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) The minimum collection frequency consistent with public health and safety should be adopted to... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommended procedures: Operations. 243.203-2 Section 243.203-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

  7. 40 CFR 243.203-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) The minimum collection frequency consistent with public health and safety should be adopted to... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Operations. 243.203-2 Section 243.203-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

  8. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended procedures: Operations. 243.202-3 Section 243.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... receive periodic vehicle safety checks, including, but not limited to, inspection of brakes, windshield...

  9. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 354.243 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Sanitary Conditions and Precautions Against Contamination of Products § 354.243 Operations and procedures... product against contamination by any foreign substance (including, but not being limited to, dust, dirt...

  10. 7 CFR 1220.243 - Confidential treatment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1220.243 Section 1220.243 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Confidential treatment. Except as otherwise provided in the Act, financial or commercial information that is...

  11. 40 CFR 243.202-3 - Recommended procedures: Operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Operations. 243.202-3 Section 243.202-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... receive periodic vehicle safety checks, including, but not limited to, inspection of brakes, windshield...

  12. 40 CFR 243.201-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... should meet the applicable provisions of the Occupational Safety and Health Administration Standards for... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Operations. 243.201-2 Section 243.201-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

  13. 40 CFR 243.203-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... minimum collection frequency consistent with public health and safety should be adopted to minimize... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommended procedures: Operations. 243.203-2 Section 243.203-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

  14. 40 CFR Appendix to Part 243 - Recommended Bibliography

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommended Bibliography Appendix to Part 243 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES.... Appendix to Part 243—Recommended Bibliography 1. American National Standard Z245.1. Safety standard for...

  15. Novel α-Tubulin Mutations Conferring Resistance to Dinitroaniline Herbicides in Lolium rigidum

    PubMed Central

    Chu, Zhizhan; Chen, Jinyi; Nyporko, Alex; Han, Heping; Yu, Qin; Powles, Stephen

    2018-01-01

    The dinitroaniline herbicides (particularly trifluralin) have been globally used in many crops for selective grass weed control. Consequently, trifluralin resistance has been documented in several important crop weed species and has recently reached a level of concern in Australian Lolium rigidum populations. Here, we report novel mutations in the L. rigidum α-tubulin gene which confer resistance to trifluralin and other dinitroaniline herbicides. Nucleotide mutations at the highly conserved codon Arg-243 resulted in amino acid substitutions of Met or Lys. Rice calli transformed with the mutant 243-Met or 243-Lys α-tubulin genes were 4- to 8-fold more resistant to trifluralin and other dinitroaniline herbicides (e.g., ethalfluralin and pendimethalin) compared to calli transformed with the wild type α-tubulin gene from L. rigidum. Comprehensive modeling of molecular docking predicts that Arg-243 is close to the trifluralin binding site on the α-tubulin surface and that replacement of Arg-243 by Met/Lys-243 results in a spatial shift of the trifluralin binding domain, reduction of trifluralin-tubulin contacts, and unfavorable interactions. The major effect of these substitutions is a significant rise of free interaction energy between α-tubulin and trifluralin, as well as between trifluralin and its whole molecular environment. These results demonstrate that the Arg-243 residue in α-tubulin is a determinant for trifluralin sensitivity, and the novel Arg-243-Met/Lys mutations may confer trifluralin resistance in L. rigidum. PMID:29472938

  16. 48 CFR 243.204-71 - Certification of requests for equitable adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Certification of requests for equitable adjustment. 243.204-71 Section 243.204-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders...

  17. 46 CFR 502.243 - Participation of absent Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AND PROCEDURE Oral Argument; Submission for Final Decision § 502.243 Participation of absent... participate in a decision shall participate in making that decision after reading the transcript of oral... 46 Shipping 9 2010-10-01 2010-10-01 false Participation of absent Commissioner. 502.243 Section...

  18. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Content of medical care evaluation studies. 456.243 Section 456.243 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Mental Hospitals...

  19. 48 CFR 243.204-71 - Certification of requests for equitable adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Certification of requests for equitable adjustment. 243.204-71 Section 243.204-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders...

  20. 49 CFR 24.3 - No duplication of payments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false No duplication of payments. 24.3 Section 24.3 Transportation Office of the Secretary of Transportation UNIFORM RELOCATION ASSISTANCE AND REAL PROPERTY... law, or insurance proceeds which is determined by the Agency to have the same purpose and effect as...

  1. 26 CFR 1.243-3 - Certain dividends from foreign corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Certain dividends from foreign corporations. 1...) INCOME TAX (CONTINUED) INCOME TAXES Special Deductions for Corporations § 1.243-3 Certain dividends from foreign corporations. (a) In general. (1) In determining the deduction provided in section 243(a), section...

  2. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Price ceiling. 243.204-70..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price. [75 FR 48277, Aug. 10, 2010] ...

  3. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Removal, suspension, or debarment. 19.243 Section 19.243 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES OF PRACTICE AND PROCEDURE Removal, Suspension, and Debarment of Accountants From Performing Audit Services § 19...

  4. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may freeze...

  5. 48 CFR 252.243-7001 - Pricing of contract modifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Pricing of contract... of Provisions And Clauses 252.243-7001 Pricing of contract modifications. As prescribed in 243.205-70, use the following clause: Pricing of Contract Modifications (DEC 1991) When costs are a factor in any...

  6. 48 CFR 2152.243-70 - Changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Changes. 2152.243-70... CONTRACT CLAUSES Text of Provisions and Clauses 2152.243-70 Changes. As prescribed in 2143.205, insert the following clause: Changes (OCT 2005) (a) Except as provided in paragraph (f) of this clause, the Contracting...

  7. 48 CFR 52.243-4 - Changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Changes. 52.243-4 Section... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.243-4 Changes... agency procedures. Changes (JUN 2007) (a) The Contracting Officer may, at any time, without notice to the...

  8. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may freeze...

  9. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may freeze...

  10. 14 CFR 121.243 - Engine breather lines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Engine breather lines. 121.243 Section 121... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Special Airworthiness Requirements § 121.243 Engine breather lines. (a) Engine breather lines must be so arranged that condensed water vapor that may freeze...

  11. 26 CFR 1.243-1 - Deduction for dividends received by corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Deduction for dividends received by corporations... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Special Deductions for Corporations § 1.243-1 Deduction for dividends received by corporations. (a)(1) A corporation is allowed a deduction under section 243 for...

  12. 14 CFR 135.243 - Pilot in command qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Pilot in command qualifications. 135.243... Crewmember Requirements § 135.243 Pilot in command qualifications. (a) No certificate holder may use a person, nor may any person serve, as pilot in command in passenger-carrying operations— (1) Of a turbojet...

  13. 14 CFR 135.243 - Pilot in command qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Pilot in command qualifications. 135.243... Crewmember Requirements § 135.243 Pilot in command qualifications. (a) No certificate holder may use a person, nor may any person serve, as pilot in command in passenger-carrying operations— (1) Of a turbojet...

  14. 14 CFR 135.243 - Pilot in command qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot in command qualifications. 135.243... Crewmember Requirements § 135.243 Pilot in command qualifications. (a) No certificate holder may use a person, nor may any person serve, as pilot in command in passenger-carrying operations— (1) Of a turbojet...

  15. 14 CFR 135.243 - Pilot in command qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Pilot in command qualifications. 135.243... Crewmember Requirements § 135.243 Pilot in command qualifications. (a) No certificate holder may use a person, nor may any person serve, as pilot in command in passenger-carrying operations— (1) Of a turbojet...

  16. 14 CFR 135.243 - Pilot in command qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Pilot in command qualifications. 135.243... Crewmember Requirements § 135.243 Pilot in command qualifications. (a) No certificate holder may use a person, nor may any person serve, as pilot in command in passenger-carrying operations— (1) Of a turbojet...

  17. 14 CFR 243.15 - Conflict with foreign laws.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Conflict with foreign laws. 243.15 Section... PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.15 Conflict with foreign laws. (a) If a... collection would violate applicable foreign law, but only to the extent it is established by the carrier that...

  18. 30 CFR 250.243 - What general information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What general information must accompany the DPP or DOCD? 250.243 Section 250.243 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... SHELF Plans and Information Contents of Development and Production Plans (dpp) and Development...

  19. 30 CFR 250.243 - What general information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or DOCD? 250.243 Section 250.243 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... production activities, include a statement so indicating. (f) Bonds, oil spill financial responsibility, and... DPP or DOCD are or will be covered by an appropriate bond under 30 CFR part 256, subpart I; (2) You...

  20. 42 CFR 456.243 - Content of medical care evaluation studies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Content of medical care evaluation studies. 456.243... Ur Plan: Medical Care Evaluation Studies § 456.243 Content of medical care evaluation studies. Each medical care evaluation study must— (a) Identify and analyze medical or administrative factors related to...

  1. 3-Amino-1,2,4-triazolium ion in [24(3at)]Cl and [24(3at)]2SnCl6·H2O. Comparative X-ray, vibrational and theoretical studies

    NASA Astrophysics Data System (ADS)

    Daszkiewicz, Marek; Marchewka, Mariusz K.

    2012-09-01

    Crystal structures of 3-amino-1,2,4-triazolium chloride and bis(3-amino-1,2,4-triazolium) hexachloridostannate monohydrate were determined by means of X-ray single crystal diffraction. The route of protonation of organic molecule and tautomer equilibrium constants for the cationic forms were calculated using B3LYP/6-31G* method. The most stable protonated species is 2,4-H2-3-amino-1,2,4-triazolium ion, 24(3at)+. Very good agreement between theoretical and experimental frequencies was achieved due to very weak interactions existing in studied compounds. Significantly weaker intermolecular interactions are found in [24(3at)]2SnCl6·H2O than in [24(3at)]Cl. The differences in strength of interactions are manifested in red and blue shifts for stretching and bending motions, respectively. PED calculations show that for 24(3at)+ ion the stretching type of motion of two Nringsbnd H bonds is independent, whereas bending is coupled.

  2. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Becker, Stephen Allan

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowsharemore » Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.« less

  3. Decay properties of Bk 97 243 and Bk 97 244

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ahmad, I.; Kondev, F. G.; Greene, J. P.

    2018-01-01

    Electron capture decays of Bk-243 and Bk-244 have been studied by measuring the gamma-ray spectra of mass-separated sources and level structures of Cm-243 and Cm-244 have been deduced. In Cm-243, the electron capture population to the ground state, 1/2(+)[631], and 1/2(+)[620] Nilsson states have been observed. The octupole K-pi = 2(-) band was identified in Cm-244 at 933.6 keV. In addition, spins and parities were deduced for several other states and two-quasiparticle configurations have been tentatively assigned to them

  4. Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.

    PubMed

    Rafael, Chloé; Soukaseum, Christelle; Baudrie, Véronique; Frère, Perrine; Hadchouel, Juliette

    2018-02-19

    Mutations of the gene encoding WNK1 [With No lysine (K) kinase 1] or WNK4 cause Familial Hyperkalemic Hypertension (FHHt). Previous studies have shown that the activation of SPAK (Ste20-related Proline/Alanine-rich Kinase) plays a dominant role in the development of FHHt caused by WNK4 mutations. The implication of SPAK in FHHt caused by WNK1 mutation has never been investigated. To clarify this issue, we crossed WNK1 +/FHHt mice with SPAK knock-in mice in which the T-loop Thr243 residue was mutated to alanine to prevent activation by WNK kinases. We show that WNK1 +/FHHT :SPAK 243A/243A mice display an intermediate phenotype, between that of control and SPAK 243A/243A mice, with normal blood pressure but hypochloremic metabolic alkalosis. NCC abundance and phosphorylation levels also decrease below the wild-type level in the double-mutant mice but remain higher than in SPAK 243A/243A mice. This is different from what was observed in WNK4-FHHt mice in which SPAK inactivation completely restored the phenotype and NCC expression to wild-type levels. Although these results confirm that FHHt caused by WNK1 mutations is dependent on the activation of SPAK, they suggest that WNK1 and WNK4 play different roles in the distal nephron.

  5. 49 CFR 234.243 - Wire on pole line and aerial cable.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Wire on pole line and aerial cable. 234.243... Maintenance, Inspection, and Testing Maintenance Standards § 234.243 Wire on pole line and aerial cable. Wire... bracket supported by a pole or other support. Wire shall not interfere with, or be interfered with by...

  6. 49 CFR 234.243 - Wire on pole line and aerial cable.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Wire on pole line and aerial cable. 234.243... Maintenance, Inspection, and Testing Maintenance Standards § 234.243 Wire on pole line and aerial cable. Wire... bracket supported by a pole or other support. Wire shall not interfere with, or be interfered with by...

  7. 30 CFR 243.5 - May another person post a bond or other surety instrument or demonstrate financial solvency on my...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... instrument or demonstrate financial solvency on my behalf? 243.5 Section 243.5 Mineral Resources MINERALS... surety instrument or demonstrate financial solvency on my behalf? Any other person, including a designee, payor, or affiliate, may post a bond or other surety instrument or demonstrate financial solvency under...

  8. 30 CFR 243.10 - When will MMS collect against a bond or other surety instrument or a person demonstrating...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... surety instrument or a person demonstrating financial solvency? 243.10 Section 243.10 Mineral Resources... a bond or other surety instrument or a person demonstrating financial solvency? (a) This section... surety instrument on your own behalf or for another person; or (2) Have demonstrated financial solvency...

  9. Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity.

    PubMed

    Al-Hadid, Qais; Roy, Kevin; Chanfreau, Guillaume; Clarke, Steven G

    2016-04-01

    Rpl3, a highly conserved ribosomal protein, is methylated at histidine 243 by the Hpm1 methyltransferase in Saccharomyces cerevisiae. Histidine 243 lies close to the peptidyl transferase center in a functionally important region of Rpl3 designated as the basic thumb that coordinates the decoding, peptidyl transfer, and translocation steps of translation elongation. Hpm1 was recently implicated in ribosome biogenesis and translation. However, the biological role of methylation of its Rpl3 substrate has not been identified. Here we interrogate the role of Rpl3 methylation at H243 by investigating the functional impact of mutating this histidine residue to alanine (rpl3-H243A). Akin to Hpm1-deficient cells, rpl3-H243A cells accumulate 35S and 23S pre-rRNA precursors to a similar extent, confirming an important role for histidine methylation in pre-rRNA processing. In contrast, Hpm1-deficient cells but not rpl3-H243A mutants show perturbed levels of ribosomal subunits. We show that Hpm1 has multiple substrates in different subcellular fractions, suggesting that methylation of proteins other than Rpl3 may be important for controlling ribosomal subunit levels. Finally, translational fidelity assays demonstrate that like Hpm1-deficient cells, rpl3-H243A mutants have defects in translation elongation resulting in decreased translational accuracy. These data suggest that Rpl3 methylation at H243 is playing a significant role in translation elongation, likely via the basic thumb, but has little impact on ribosomal subunit levels. Hpm1 is therefore a multifunctional methyltransferase with independent roles in ribosome biogenesis and translation. © 2016 Al-Hadid et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  10. THE FUNDUS PHENOTYPE ASSOCIATED WITH THE p.Ala243Val BEST1 MUTATION.

    PubMed

    Khan, Kamron N; Islam, Farrah; Moore, Anthony T; Michaelides, Michel

    2018-03-01

    To describe a highly recognizable and reproducible retinal phenotype associated with a specific BEST1 mutation-p.Ala243Val. Retrospective review of consecutive cases where genetic testing has identified p.Ala243Val BEST1 as the cause of disease. Electronic patient records were used to extract demographic, as well as functional and anatomical data. These data were compared with those observed with the most common BEST1 genotype, p.Arg218Cys. Eight individuals (six families) were identified with the p.Ala243Val BEST1 mutation and seven patients with the pathologic variant p.Arg218Cys. No patients with mutation of codon 243 knowingly had a family history of retinal disease, whereas all patients with the p.Arg218Cys variant did. The maculopathy was bilateral in all cases. The p.Ala243Val mutation was associated with a pattern dystrophy-type appearance, most visible with near-infrared reflectance and fundus autofluorescence imaging. This phenotype was never observed with any other genotype. This mutation was associated with an older median age of symptom onset (median = 42, interquartile range = 22) compared with those harboring the p.Arg218Cys mutation (median = 18, interquartile range = 12; Mann-Whitney U test; P < 0.05). Despite their older age, the final recorded acuity seemed to be better in the p.Ala243Val group (median = 0.55, interquartile range = 0.6475; median = 0.33, interquartile range = 0.358), although this did not reach statistical significance (Mann-Whitney U test; P > 0.05). The mutation p.Ala243Val is associated with highly recognizable and reproducible pattern dystrophy-like phenotype. Patients develop symptoms at a later age and tend to have better preservation of electrooculogram amplitudes.

  11. 30 CFR 243.7 - What must a person do when posting a bond or other surety instrument or demonstrating financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....7 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE... instrument or demonstrate financial solvency under § 243.5, you: (a) Must notify MMS in writing at the address specified in § 243.200(a) that you are assuming the appellant's responsibility under this part; (b...

  12. 19 CFR 24.3a - CBP bills; interest assessment; delinquency; notice to principal and surety.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false CBP bills; interest assessment; delinquency; notice to principal and surety. 24.3a Section 24.3a Customs Duties U.S. CUSTOMS AND BORDER PROTECTION....3a CBP bills; interest assessment; delinquency; notice to principal and surety. (a) Due date of CBP...

  13. The effect of co-administration of DNA carrying chicken interferon-gamma gene on protection of chickens against infectious bursal disease by DNA-mediated vaccination.

    PubMed

    Hsieh, Ming Kun; Wu, Ching Ching; Lin, Tsang Long

    2006-11-17

    The purpose of the present study was to determine whether DNA vaccination by co-administration of DNA coding for chicken interferon-gamma (IFN-gamma) gene and DNA encoding for the VP243 gene of IBDV could enhance immune response and protection efficacy of chickens against challenge by IBDV. Plasmids carrying VP243 gene of IBDV strain variant E (VE) (P/VP243/E) and chicken IFN-gamma gene (P/cIFN-gamma) were constructed, respectively. One-day-old chickens were intramuscularly injected with P/VP243/E, or P/cIFN-gamma, or both once, twice, or three times into the thigh muscle of one leg or the thigh muscles of two separate legs at weekly intervals. Chickens were orally challenged with IBDV strain VE at 3 weeks of age and observed for 10 days. Chickens receiving two plasmids in the same site two times had significantly higher (P<0.05) bursal lesion scores and significantly lower (P<0.05) bursa weight/body weight ratios than those that only received P/VP243/E two or three times. Chickens inoculated with two plasmids separately in the thigh muscles of different legs or P/VP243/E two times had 33-50% protection and those receiving two plasmids in the same sites did not have any protection against IBD. The enzyme-linked immunosorbent assay (ELISA) and virus neutralization (VN) titers to IBDV of chickens in the groups with three doses of P/VP243/E were significantly higher (P<0.05) than those in groups receiving two doses of P/VP243/E or P/VP243/E and P/cIFN-gamma. Chickens protected by DNA vaccination did not have detectable IBDV antigen in the bursae as determined by immunofluorescent antibody assay (IFA). The results indicated that co-administration of plasmid encoding chicken IFN-gamma gene with plasmid encoding a large segment gene of the IBDV did not enhance immune response and protection against challenge by IBDV.

  14. 40 CFR 1065.703 - Distillate diesel fuel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 1 Cetane Number 40-50 40-50 40-50 ASTM D613-05. Distillation range: Initial boiling point °C 171-204 171-204 171-204 ASTM D86-07a. 10 pct. point 204-238 204-238 204-238 50 pct. point 243-282 243-282 243...-37 ASTM D4052-96e01. Total sulfur, ultra low sulfur mg/kg 7-15 See 40 CFR 80.580. Total sulfur, low...

  15. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the...

  16. 49 CFR 40.243 - What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What is the procedure for an alcohol screening test using an EBT or non-evidential breath ASD? 40.243 Section 40.243 Transportation Office of the...-evidential breath ASD? As the BAT or STT, you must take the following steps: (a) Select, or allow the...

  17. CL316,243, a β3-adrenergic receptor agonist, induces muscle hypertrophy and increased strength.

    PubMed

    Puzzo, Daniela; Raiteri, Roberto; Castaldo, Clotilde; Capasso, Raffaele; Pagano, Ester; Tedesco, Mariateresa; Gulisano, Walter; Drozd, Lisaveta; Lippiello, Pellegrino; Palmeri, Agostino; Scotto, Pietro; Miniaci, Maria Concetta

    2016-11-22

    Studies in vitro have demonstrated that β3-adrenergic receptors (β3-ARs) regulate protein metabolism in skeletal muscle by promoting protein synthesis and inhibiting protein degradation. In this study, we evaluated whether activation of β3-ARs by the selective agonist CL316,243 modifies the functional and structural properties of skeletal muscles of healthy mice. Daily injections of CL316,243 for 15 days resulted in a significant improvement in muscle force production, assessed by grip strength and weight tests, and an increased myofiber cross-sectional area, indicative of muscle hypertrophy. In addition, atomic force microscopy revealed a significant effect of CL316,243 on the transversal stiffness of isolated muscle fibers. Interestingly, the expression level of mammalian target of rapamycin (mTOR) downstream targets and neuronal nitric oxide synthase (NOS) was also found to be enhanced in tibialis anterior and soleus muscles of CL316,243 treated mice, in accordance with previous data linking β3-ARs to mTOR and NOS signaling pathways. In conclusion, our data suggest that CL316,243 systemic administration might be a novel therapeutic strategy worthy of further investigations in conditions of muscle wasting and weakness associated with aging and muscular diseases.

  18. Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation

    PubMed Central

    Park, Inai; Lee, Hae-ock; Choi, Eunhee; Lee, Yoo-Kyung; Kwon, Mi-Sun; Min, Jaewon; Park, Pil-Gu; Lee, Seonju; Kong, Young-Yun; Gong, Gyungyub

    2013-01-01

    BubR1 acetylation is essential in mitosis. Mice heterozygous for the acetylation-deficient BubR1 allele (K243R/+) spontaneously developed tumors with massive chromosome missegregations. K243R/+ mouse embryonic fibroblasts (MEFs) exhibited a weakened spindle assembly checkpoint (SAC) with shortened mitotic timing. The generation of the SAC signal was intact, as Mad2 localization to the unattached kinetochore (KT) was unaltered; however, because of the premature degradation of K243R-BubR1, the mitotic checkpoint complex disassociated prematurely in the nocodazole-treated condition, suggesting that maintenance of the SAC is compromised. BubR1 acetylation was also required to counteract excessive Aurora B activity at the KT for stable chromosome–spindle attachments. The association of acetylation-deficient BubR1 with PP2A-B56α phosphatase was reduced, and the phosphorylated Ndc80 at the KT was elevated in K243R/+ MEFs. In relation, there was a marked increase of micronuclei and p53 mutation was frequently detected in primary tumors of K243R/+ mice. Collectively, the combined effects of failure in chromosome–spindle attachment and weakened SAC cause genetic instability and cancer in K243R/+ mice. PMID:23878276

  19. 7 CFR 1220.243 - Confidential treatment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Reports, Books, and Records § 1220.243...

  20. 15 CFR 904.243 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Discovery § 904.243 Admissions. (a) Request. If ordered by the Judge, any party...

  1. 15 CFR 904.243 - Admissions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Discovery § 904.243 Admissions. (a) Request. If ordered by the Judge, any party...

  2. Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain.

    PubMed

    Zhao, Ling-Jun; Loewenstein, Paul M; Green, Maurice

    2016-12-01

    The adenovirus E1A 243R oncoprotein targets TRRAP, a scaffold protein that assembles histone acetyltransferase (HAT) complexes, such as the NuA4/Tip60 complex which mediates transcriptional activity of the proto-oncogene MYC and helps determine the cancer cell phenotype. How E1A transforms cells through TRRAP remains obscure. We performed proteomic analysis with the N-terminal transcriptional repression domain of E1A 243R (E1A 1-80) and showed that E1A 1-80 interacts with TRRAP, p400, and three other members of the NuA4 complex - DMAP1, RUVBL1 and RUVBL2 - not previously shown to associate with E1A 243R. E1A 1-80 interacts with these NuA4 components and MYC through the E1A TRRAP-targeting domain. E1A 243R association with the NuA4 complex was demonstrated by co-immunoprecipitation and analysis with DMAP1, Tip60, and MYC. Significantly, E1A 243R promotes association of MYC/MAX with the NuA4/Tip60 complex, implicating the importance of the MYC/NuA4 pathway in cellular transformation by both MYC and E1A. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice.

    PubMed

    Choi, S-P; Oh, H-N; Choi, C-Y; Ahn, H; Yun, H S; Chung, Y M; Kim, B; Lee, S J; Chun, T

    2018-03-01

    In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis. Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-γ) and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE and BP-specific serum IgG1 were decreased, whereas secretion of IFN-γ and BP-specific serum IgG2a was augmented upon administration of CJLP133 and CJLP243 in mice. Oral administration of L. plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response. Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model. © 2017 The Society for Applied Microbiology.

  4. Early or Premature Menopause

    MedlinePlus

    ... gov/widgets/fahc.html" width="243" height="179" title="Find a Health Center Widget" scrolling="no">https:// ... gov/widgets/fahc.html" width="243" height="179" title="Find a Health Center Widget" scrolling="no">https:// ...

  5. 48 CFR 243.204-70-6 - Allowable profit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-6 Allowable profit. When the final price of an unpriced change order is negotiated after a substantial portion...

  6. 48 CFR 243.204-70-6 - Allowable profit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-6 Allowable profit. When the final price of an unpriced change order is negotiated after a substantial portion...

  7. 48 CFR 243.204-70-2 - Price ceiling.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-2 Price ceiling. Unpriced change orders shall include a not-to-exceed price. [75 FR 48277, Aug. 10, 2010] ...

  8. The use of MOX caramel fuel mixed with 241Am, 242mAm and 243Am as burnable absorber actinides for the MTR research reactors.

    PubMed

    Shaaban, Ismail; Albarhoum, Mohamad

    2017-07-01

    The MOX (UO 2 &PuO 2 ) caramel fuel mixed with 241 Am, 242m Am and 243 Am as burnable absorber actinides was proposed as a fuel of the MTR-22MW reactor. The MCNP4C code was used to simulate the MTR-22MW reactor and estimate the criticality and the neutronic parameters, and the power peaking factors before and after replacing its original fuel (U 3 O 8 -Al) by the MOX caramel fuel mixed with 241 Am, 242m Am and 243 Am actinides. The obtained results of the criticality, the neutronic parameters, and the power peaking factors for the MOX caramel fuel mixed with 241 Am, 242m Am and 243 Am actinides were compared with the same parameters of the U 3 O 8 -Al original fuel and a maximum difference is -6.18% was found. Additionally, by recycling 2.65% and 2.71% plutonium and 241 Am, 242m Am and 243 Am actinides in the MTR-22MW reactor, the level of 235 U enrichment is reduced from 4.48% to 3% and 2.8%, respectively. This also results in the reduction of the 235 U loading by 32.75% and 37.22% for the 2.65%, the 2.71% plutonium and 241 Am, 242m Am and 243 Am actinides, respectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change orders. ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Definitization of change...

  10. 48 CFR 1843.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... prefaces of clauses FAR 52.243-1, Changes—Fixed Price; FAR 52.243-2, Changes—Cost Reimbursement; and FAR 52... Labor-Hours, the period within which a contractor must assert its right to an equitable adjustment may...

  11. 48 CFR 243.204-70 - Definitization of change orders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70 Definitization of change orders. ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Definitization of change...

  12. Airborne urban/suburban noise measurements at 121.5/243 MHz

    NASA Technical Reports Server (NTRS)

    Taylor, R. E.; Hill, J. S.

    1977-01-01

    An airborne measurement of the terrestrial, radio-frequency (RF) noise environment over U.S. metropolitan urban/suburban areas has been made at the 121.5/243 MHz emergency-distress search and rescue (S&R) communications frequencies. Profile contour plots of antenna-noise temperature for U.S.A. East Coast and mid-west urban/suburban areas is presented for daytime/nighttime observations at 121.5/243 MHz. These plots are helpful for compiling radio-noise environment maps; in turn useful for designing satellite-aided, emergency-distress search and rescue communication systems.

  13. Decay properties of Bk24397 and Bk24497

    NASA Astrophysics Data System (ADS)

    Ahmad, I.; Kondev, F. G.; Greene, J. P.; Zhu, S.

    2018-01-01

    Electron capture decays of 243Bk and 244Bk have been studied by measuring the γ -ray spectra of mass-separated sources and level structures of 243Cm and 244Cm have been deduced. In 243Cm, the electron capture population to the ground state, 1 /2+[631 ] , and 1 /2+[620 ] Nilsson states have been observed. The octupole Kπ=2- band was identified in 244Cm at 933.6 keV. In addition, spins and parities were deduced for several other states and two-quasiparticle configurations have been tentatively assigned to them.

  14. Effect of pH and aging time on the kinetic dissociation of 243Am(III) from humic acid-coated gamma-Al2O3: a chelating resin exchange study.

    PubMed

    Wang, Xiangke; Chen, Changlun; Du, Jinzhou; Tan, Xiaoli; Di, Xu; Yu, Shaoming

    2005-09-15

    The chelating resin was studied to assess its influence on metal availability and mobility in the environment. The association of organic-inorganic colloid-borne trace elements was investigated in this work. The radionuclide 243Am(III) was chosen as the representative and chemical homologue for trivalent lanthanide and actinide ions present in radioactive nuclear waste. The kinetic dissociation behavior of 243Am(III) from humic acid-coated gamma-Al2O3 was studied at pH values of 4.0 +/- 0.1, 5.0 +/- 0.2, and 6.0 +/- 0.2 with a contact time of 2 days after the addition of a chelating cation exchanger resin. The concentrations of the components were: 243Am(III) 3.0 x 10(-7) mol/L, gamma-Al2O3 0.5 g/L, HA 10 mg/L (pH 4.0 +/- 0.1, 5.0 +/- 0.2, and 6.0 +/- 0.2) and 50 mg/L (pH 6.0 +/- 0.2), respectively. The kinetics of dissociation of 243Am(III) after different equilibration time with humic acid-coated gamma-Al2O3 was also investigated at pH 5.0 +/- 0.2. The experiments were carried out in air and at ambient temperature. The results suggest that the fraction of irreversible bonding of radionuclides to HA-coated Al2O3 increases with increasing pH and is independent of aging time. The assumption of two different 243Am(III)-HA-Al2O3 species, with "fast" and "slow" dissociation kinetics, is required to explain the experimental results. 243Am(III) species present on HA-Al2O3 colloids moves from the "fast" to the "slow" dissociating sites with the increase of aging time.

  15. CL 316, 243 mediated reductions in blood glucose are enhanced in RIP140{sup −/−} mice independent of alterations in lipolysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peppler, Willem T.; Miotto, Paula M.; Holloway, Graham P.

    The β-3 adrenergic agonist CL 316, 243 acutely lowers blood glucose through a mechanism thought to involve fatty-acid induced insulin release. The purpose of this study was to determine if ablation of the nuclear receptor, receptor-inactivating protein 140 (RIP140), altered this response. Here, we used a single injection of CL 316, 243 (1 mg/kg) and found that whole body RIP140{sup −/−} mice had a greater decline in blood glucose over 2 h. This occurred alongside increased hexokinase II (HKII) protein content in adipose tissue and skeletal muscle, but independent of changes in circulating insulin or indices of lipolysis. These data indicate thatmore » RIP140 has a unique role in the acute effect of β-3 adrenergic receptor activation using CL 316, 243.« less

  16. Ordinary Chondrite Spectral Signatures in the 243 Ida Asteroid System

    NASA Astrophysics Data System (ADS)

    Granahan, J. C.

    2012-12-01

    The NASA Galileo spacecraft observed asteroid 243 Ida and satellite Dactyl on August 28, 1993, with the Near Infrared Mapping Spectrometer (NIMS) at wavelengths ranging from 0.7 to 5.2 micrometers[Carlson et al., 1994]. Work is being conducted to produce radiance-calibrated spectral images of 243 Ida consisting of 17-channel, 299 meters per pixel files and a 102-channel, 3.2 kilometer per pixel NIMS observations of 243 Ida for the NASA Planetary Data System (PDS). These data are currently archived in PDS as uncalibrated data number counts. Radiometric calibrated 17-channel and 102-channel NIMS spectral data files of Dactyl and light curve 243 Ida observations are also being prepared. Analysis of this infrared asteroid data has confirmed that both 243 Ida and Dactyl are S-type asteroid objects and found that their olivine and pyroxene mineral abundances are consistent with that of ordinary chondrite meteorites. Tholen [1989] identified 243 Ida and Chapman et al. [1995] identified Dactyl as S-type asteroids on the basis of spectral data ranging from 0.4 to 1.0 micrometers. S-type are described [Tholen, 1989] as asteroids with a moderate albedos, a moderate to strong absorption feature shortward of 0.7 micrometers, and moderate to nonexistent absorption features longward of 0.7 micrometers. DeMeo et al. [2009] found 243 Ida to be a Sw asteroid based on Earth-based spectral observations 0.4 to 2.5 micrometers in range. Sw is a subclass of S-type asteroids that has a space weathering spectral component [DeMeo et al., 2009]. The NIMS data 243 Ida and Dactyl processed in this study exhibit signatures consistent with the Sw designation of DeMeo et al. [2009]. Measurements of olivine and pyroxene spectral bands were also conducted for the NIMS radiance data of 243 Ida and Dactyl. Band depth and band center measurements have been used to compare S-type asteroids with those of meteorites [Dunn et al., 2010; Gaffey et al., 1993]. The 243 Ida spectra were found to be consistent with those of Granahan [2002] and corresponded to measurements of LL chondrites. Dactyl was found to have spectral bands that correlate to L chondrite meteorite signatures as measured by Dunn et al. [2010]. The spectra band measurements of both objects correspond to those of the SIV class [Gaffey et al., 1993] of the S asteroids. Both L and LL chondrites are types of ordinary chondrite meteorites. Carlson, R. W., et al. (1994), Bulletin of the American Astronomical Society, 26, 1156. Chapman, C. R., et al. (1995), Nature, 374, 783-785. DeMeo, F. E., R. P. Binzel, S. M. Slivan, and S. J. Bus (2009), Icarus, 202, 160-180. Dunn, T. L., T. J. McCoy, J. M. Sunshine, and H. Y. McSween (2010), Icarus, 208, 789-797. Gaffey, M. J., J. F. Bell, R. H. Brown, T. H. Burbine, J. L. Piatek, K. L. Reed, and D. A. Chaky (1993), Icarus, 106, 573-602. Granahan, J. C. (2002), Journal of Geophysical Research Planets, 107(E10), 5090-5100. Tholen, D. J. (1989), in Asteroids II, edited by R. P. Binzel, T. Gehrels, and M.S. Matthews, pp. 1139-1150, University of Arizona Press, Tucson.

  17. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.243 What special provisions... building codes and applicable engineering standards, appropriate for the particular project; and (3...

  18. 48 CFR 543.205 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 543.205 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 543.205 Contract clauses. The contracting officer shall insert 552.243-71, Equitable Adjustments, in solicitations and contracts containing FAR 52.243-4, Changes. [74 FR...

  19. 40 CFR 86.243-94 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1994 and Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.243-94 [Reserved] ...

  20. Hydration Experiments and Physical Observations at 193 K and 243 K for Mg-Sulfates Relevant to Mars

    NASA Astrophysics Data System (ADS)

    Vaniman, D. T.; Chipera, S. J.; Carey, J. W.

    2006-03-01

    Hydration of kieserite and amorphous Mg-sulfate at 243 K progresses along simple pathways involving only hexahydrite and kieserite. Kieserite forms a duricrust-like cement, but the anhydrous precursor does not.

  1. 77 FR 70366 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... Airworthiness Directives; Airbus Airplanes AGENCY: Federal Aviation Administration (FAA), Department of... Airbus Model A330-243, -243F, -341, -342, and -343 airplanes equipped with Rolls-Royce Trent 700 engines...: Vladimir Ulyanov, Aerospace Engineer, International Branch, ANM-116, Transport Airplane Directorate, FAA...

  2. 48 CFR 543.205 - Contract clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 543.205 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 543.205 Contract clauses. The contracting officer shall insert 552.243-71, Equitable Adjustments, in solicitations and contracts containing FAR 52.243-4, Changes. [74 FR...

  3. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... agency including technical data and policy considerations used in arriving at this decision. In covering... AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID WASTE General Provisions § 243.100... Disposal Act, as amended (Pub. L. 89-272). (b) The guidelines apply to the collection of residential...

  4. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... diameter at the top of the container to facilitate discharge of the solid waste by gravity. Containers...-2 Section 243.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID...

  5. 48 CFR 243.204-70-7 - Plans and reports.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-7 Plans and reports. To provide for enhanced management and oversight of unpriced change orders, departments and agencies shall— (a) Include in the Consolidated Undefinitized Contract Action (UCA) Management...

  6. 39 CFR 243.2 - Quarters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION CONDUCT OF OFFICES § 243.2 Quarters. (a.... Postal Service, General Accounting Office Building, Washington, DC 20260, with a memorandum of... depositing mail in front of or next to the post office. Show collection time schedules on letterboxes. At...

  7. 48 CFR 243.204-70-1 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Director, Defense Procurement and Acquisition Policy (Contract Policy and International Contracting), 3060..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-1 Scope. (a) This..., but the contracting officer shall apply the policy and procedures to them to the maximum extent...

  8. 48 CFR 243.204-70-1 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Director, Defense Procurement and Acquisition Policy (Contract Policy and International Contracting), 3060..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-1 Scope. (a) This..., but the contracting officer shall apply the policy and procedures to them to the maximum extent...

  9. Cranial shape variation in jacarean caimanines (Crocodylia, Alligatoroidea) and its implications in the taxonomic status of extinct species: The case of Melanosuchus fisheri.

    PubMed

    Foth, Christian; Fernandez Blanco, María Victoria; Bona, Paula; Scheyer, Torsten M

    2018-02-01

    Melanosuchus niger (Crocodylia, Alligatoroidea) is one of the six living caimanine species widely distributed throughout the Amazon River basin today. Although there is only one extant species of Melanosuchus, fossil material assigned to this genus, represented by M. fisheri, has been reported from the late Miocene in South America. However, the validity of this taxon has been questioned and a recent investigation indicates that the referred specimen of M. fisheri (MCZ 4336) actually belongs to Globidentosuchus brachyrostris, while those diagnostic characters present in the holotype (MCNC 243) fall into the spectrum of intraspecific variation of M. niger. Here, we compare the skull shape of the holotype of M. fisheri with the ontogenetic series of the four jacarean species (M. niger, Caiman yacare, Caiman crocodilus, and Caiman latirostris) using 2D-geometric morphometric analyses in two different views. The analyses indicate that MCNC 243 falls into the morphospace of M. niger and C. latirostris. Despite strong shape similarities between juveniles of C. latirostris and MCNC 243, further anatomical comparisons reveal notable differences between them. In contrast, no concrete anatomical differences can be found between MCNC 243 and M. niger, although shape analyses indicate that MCNC 243 is relatively robust for its size. Thus, this study is able to confirm that the genus Melanosuchus was present in the late Miocene, but it still remains unclear if MCNC 243 should be treated as a junior synonym or probably a sister species of M. niger. Its Miocene age favors the second option, but as the shape analyses were also not able to extract any diagnostic characters, it should be retained as Melanosuchus cf. niger. © 2017 Wiley Periodicals, Inc.

  10. Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues.

    PubMed

    Zhang, Wenlong; Zhang, Xiuping; Qu, Shaogang

    2018-07-01

    Glutamatergic synaptic transmitters are cleared from the synaptic cleft through excitatory amino acid transporters (EAATs) that are responsible for recycling glutamate and transporting it into neurons and glial cells. To probe the structural role of the TM4b-4c loop of EAAT1 ( Rattus norvegicus ), each of the 57 amino acid residues was mutated to cysteine. Thirteen of the single mutants have very low transport activity. Aqueous accessibility of the introduced cysteines from the remaining mutants was then explored by membrane-permeant and membrane-impermeant sulfhydryl reagents in different conditions. F190C, V238C, and A243C were affected by MTSET, whereas Q189C, F190C, V238C, A243C, and L244C were sensitive to MTSEA. Q189C and L244C transport activity was diminished in the presence of potassium, which is expected to favor the inward-facing conformation of the transporter. Inversely, L244C was protected by glutamate. The modification of A243C by MTSEA was enhanced by either potassium and glutamate or dl- threo -β-benzyloxyaspartate. From these results, we suggest that residues F190C, V238C, and A243C may be located near the extracellular surface, and the TM4b-4c loop forms multiple reentrant membrane loops on the cell surface. Alternatively, F190C, V238C, and A243C may function in the transport pathway, which is exposed to MTSET. In addition, Q189C, A243C, and L244C are conformationally sensitive and may play a role in the transport cycle. Copyright © 2018 by The Author(s).

  11. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... diameter at the top of the container to facilitate discharge of the solid waste by gravity. Containers....200-2 Section 243.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID...

  12. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... diameter at the top of the container to facilitate discharge of the solid waste by gravity. Containers....200-2 Section 243.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID...

  13. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... diameter at the top of the container to facilitate discharge of the solid waste by gravity. Containers....200-2 Section 243.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL SOLID...

  14. 48 CFR 243.204-70-3 - Definitization schedule.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-3 Definitization schedule. (a) Unpriced change orders shall contain definitization schedules that provide for definitization by the earlier of— (1) The date that is 180 days after issuance of the change...

  15. 48 CFR 243.204-70-3 - Definitization schedule.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204-70-3 Definitization schedule. (a) Unpriced change orders shall contain definitization schedules that provide for definitization by the earlier of— (1) The date that is 180 days after issuance of the change...

  16. A clinical investigation of the efficacy of three commercially available dentifrices for controlling established gingivitis and supragingival plaque.

    PubMed

    Singh, Surrendra; Chaknis, Patricia; DeVizio, William; Petrone, Margaret; Panagakos, Fotinos S; Proskin, Howard M

    2010-01-01

    To assess the efficacy ofa dentifrice containing 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride for controlling established gingivitis and supragingival plaque relative to that of a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate, and a dentifrice containing 0.243% sodium fluoride as a negative control. Following a baseline examination for gingivitis and supragingival plaque, qualifying adult male and female subjects from the Piscataway, NJ, USA area were randomized into three dentifrice groups. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice and a soft-bristled toothbrush. Examinations for gingivitis and supragingival plaque were repeated after six weeks of product use. One-hundred and seventy-one (171) subjects complied with the protocol and completed the study. Relative to the group using the dentifrice with 0.243% sodium fluoride alone, the 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride group exhibited statistically significant reductions in gingival index and supragingival plaque index scores of 25.3% and 33.0%, respectively, after six weeks of product use. Similarly, relative to the group using the 0.243% sodium fluoride dentifrice, the 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate dentifrice group exhibited statistically significant reductions in gingival index and plaque index scores of 8.1% and 14.1% after six weeks of product use. Further, relative to the 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate dentifrice group, the 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride dentifrice group exhibited statistically significant reductions in gingival index and plaque index scores of 18.7% and 22%, respectively. The overall results of this double-blind clinical study support the conclusion that a dentifrice containing 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride is efficacious for the control of established gingivitis and supragingival plaque as compared to a regular fluoride dentifrice, and that it provides a greater level of efficacy for the control of gingivitis and supragingival plaque than does a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate.

  17. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause prescriptions at 217.7406 for all unpriced change orders with an... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Unpriced change orders...

  18. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... abuse professionals and counseling and treatment programs. (b) Each covered employee who engages in conduct prohibited under §§ 199.215 through 199.223 shall be evaluated by a substance abuse professional...

  19. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... abuse professionals and counseling and treatment programs. (b) Each covered employee who engages in conduct prohibited under §§ 199.215 through 199.223 shall be evaluated by a substance abuse professional...

  20. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... abuse professionals and counseling and treatment programs. (b) Each covered employee who engages in conduct prohibited under §§ 199.215 through 199.223 shall be evaluated by a substance abuse professional...

  1. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... abuse professionals and counseling and treatment programs. (b) Each covered employee who engages in conduct prohibited under §§ 199.215 through 199.223 shall be evaluated by a substance abuse professional...

  2. 49 CFR 199.243 - Referral, evaluation, and treatment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ALCOHOL TESTING Alcohol Misuse Prevention Program § 199.243 Referral, evaluation, and treatment. (a) Each... abuse professionals and counseling and treatment programs. (b) Each covered employee who engages in conduct prohibited under §§ 199.215 through 199.223 shall be evaluated by a substance abuse professional...

  3. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Engineering change... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert the following clause, modified to suit contract type: Engineering Change Proposals (FEB 1998) (a) Definitions...

  4. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Engineering change... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert the following clause, modified to suit contract type: Engineering Change Proposals (FEB 1998) (a) Definitions...

  5. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Engineering change... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert the following clause, modified to suit contract type: Engineering Change Proposals (FEB 1998) (a) Definitions...

  6. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Engineering change... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert the following clause, modified to suit contract type: Engineering Change Proposals (FEB 1998) (a) Definitions...

  7. 48 CFR 1852.243-70 - Engineering change proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Engineering change... and Clauses 1852.243-70 Engineering change proposals. As prescribed in 1843.205-70(a)(1), insert the following clause, modified to suit contract type: Engineering Change Proposals (FEB 1998) (a) Definitions...

  8. 48 CFR 52.243-7 - Notification of Changes.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....243-7 Notification of Changes. As prescribed in 43.107, insert the following clause: Notification of Changes (APR 1984) (a) Definitions. Contracting Officer, as used in this clause, does not include any representative of the Contracting Officer. Specifically Authorized Representative (SAR), as used in this clause...

  9. 48 CFR 52.243-7 - Notification of Changes.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ....243-7 Notification of Changes. As prescribed in 43.107, insert the following clause: Notification of Changes (APR 1984) (a) Definitions. Contracting Officer, as used in this clause, does not include any representative of the Contracting Officer. Specifically Authorized Representative (SAR), as used in this clause...

  10. 48 CFR 52.243-7 - Notification of Changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....243-7 Notification of Changes. As prescribed in 43.107, insert the following clause: Notification of Changes (APR 1984) (a) Definitions. Contracting Officer, as used in this clause, does not include any representative of the Contracting Officer. Specifically Authorized Representative (SAR), as used in this clause...

  11. 48 CFR 52.243-7 - Notification of Changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....243-7 Notification of Changes. As prescribed in 43.107, insert the following clause: Notification of Changes (APR 1984) (a) Definitions. Contracting Officer, as used in this clause, does not include any representative of the Contracting Officer. Specifically Authorized Representative (SAR), as used in this clause...

  12. 48 CFR 52.243-7 - Notification of Changes.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ....243-7 Notification of Changes. As prescribed in 43.107, insert the following clause: Notification of Changes (APR 1984) (a) Definitions. Contracting Officer, as used in this clause, does not include any representative of the Contracting Officer. Specifically Authorized Representative (SAR), as used in this clause...

  13. 243. Photocopy of drawing (1958 piping drawing by the Ralph ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    243. Photocopy of drawing (1958 piping drawing by the Ralph M. Parsons Company) WATER SYSTEMS FLOW DIAGRAM FOR THE LSB, SHEET P6 OF 36 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  14. 48 CFR 243.205-72 - Unpriced change orders.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.205-72 Unpriced change orders. See the clause prescriptions at 217.7406 for all unpriced change orders with an... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Unpriced change orders...

  15. 76 FR 73496 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ...) that applies to certain Airbus Model A330-201, -202, -203, -223, -243, -301, -302, -303, -321, -322..., -322, -323, -341, -342, and -343 airplanes, all serial numbers, except those on which Airbus... Service Information (g) For Model A330-201, -202, -203, -223, -243, -301, -321, - 322, -323, -341, -342...

  16. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed by...

  17. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed by...

  18. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed by...

  19. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed by...

  20. 40 CFR 81.243 - Central Minnesota Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Central Minnesota Intrastate Air... Air Quality Control Regions § 81.243 Central Minnesota Intrastate Air Quality Control Region. The Central Minnesota Intrastate Air Quality Control Region consists of the territorial area encompassed by...

  1. 26 CFR 1.243-3 - Certain dividends from foreign corporations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Certain dividends from foreign corporations. 1...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-3 Certain dividends from foreign corporations. (a) In general. (1) In determining the deduction provided in section...

  2. 26 CFR 1.243-3 - Certain dividends from foreign corporations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 3 2013-04-01 2013-04-01 false Certain dividends from foreign corporations. 1...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-3 Certain dividends from foreign corporations. (a) In general. (1) In determining the deduction provided in section...

  3. 26 CFR 1.243-3 - Certain dividends from foreign corporations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 3 2012-04-01 2012-04-01 false Certain dividends from foreign corporations. 1...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-3 Certain dividends from foreign corporations. (a) In general. (1) In determining the deduction provided in section...

  4. 26 CFR 1.243-3 - Certain dividends from foreign corporations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 3 2014-04-01 2014-04-01 false Certain dividends from foreign corporations. 1...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Special Deductions for Corporations § 1.243-3 Certain dividends from foreign corporations. (a) In general. (1) In determining the deduction provided in section...

  5. 43 CFR 24.3 - General jurisdictional principles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FISH AND WILDLIFE POLICY: STATE-FEDERAL RELATIONSHIPS § 24.3 General jurisdictional principles. (a) In..., including fish and wildlife found on Federal lands within a State. Under the Property Clause of the Constitution, Congress is given the power to “make all needful Rules and Regulations respecting the Territory...

  6. 75 FR 24571 - Designation of New Grantee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1676] Designation of New Grantee Foreign-Trade Zone 243, Victorville, California Resolution and Order Pursuant to its authority under the... recognizes the City of Victorville as the new grantee of Foreign-Trade Zone 243, subject to the FTZ Act and...

  7. 77 FR 26998 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ...-0428; Directorate Identifier 2011-NM-078-AD] RIN 2120-AA64 Airworthiness Directives; Airbus Airplanes...: We propose to adopt a new airworthiness directive (AD) for all Airbus Model A330-243, -243F, -342..., between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. For Airbus service information...

  8. U.S. Trends in Solid Waste Management and GHG Emissions

    EPA Science Inventory

    In 2009, 243 million tons of municipal solid waste (MSW) was produced in the United States. Currently, 34% of the 243 million tons of MSW is recovered and recycled or composted which conserves energy and natural resources as well as avoid waste disposal. Of the remaining MSW th...

  9. 48 CFR 52.243-5 - Changes and Changed Conditions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Changes and Changed....243-5 Changes and Changed Conditions. As prescribed in 43.205(e), insert the following clause: Changes and Changed Conditions (APR 1984) (a) The Contracting Officer may, in writing, order changes in the...

  10. 48 CFR 52.243-2 - Changes-Cost-Reimbursement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Changes-Cost-Reimbursement....243-2 Changes—Cost-Reimbursement. As prescribed in 43.205(b)(1), insert the following clause. The 30-day period may be varied according to agency procedures. Changes—Cost-Reimbursement (AUG 1987) (a) The...

  11. 48 CFR 52.243-6 - Change Order Accounting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Change Order Accounting....243-6 Change Order Accounting. As prescribed in 43.205(f), the contracting officer may insert a clause, substantially the same as follows: Change Order Accounting (APR 1984) The Contracting Officer may require change...

  12. Airborne surveys of USA urban areas at 121.5/243 MHz

    NASA Technical Reports Server (NTRS)

    Taylor, R. E.; Hill, J. S.

    1979-01-01

    In situ, aircraft flight measurements were made in 1976 and 1977 by NASA of the radio-frequency environment over USA urban areas within the emergency distress search and rescue frequency bands at 121.5 and 243.0 MHz. This paper analyzes test results reported previously for USA East Coast and Midwest flight surveys; presented also are test results obtained in May 1977 for the USA West Coast during the NASA, ASSESS-II, Space Shuttle/Spacelab simulation aircraft flights. The USA West Coast flight include data at 121.5/243 MHz during an extensive series of aircraft passes for the Los Angeles urban area. The USA East Coast/Midwest measurements show correlation with population count.

  13. 27 CFR 28.243 - Shipment to armed services.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....243 Shipment to armed services. On removal of distilled spirits, wines, or beer for export to the armed services of the United States, the shipment shall be consigned to the commanding officer or supply... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Shipment to armed services...

  14. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks tax...

  15. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks tax...

  16. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks tax...

  17. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks tax...

  18. 27 CFR 46.243 - Articles at multiple locations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks tax...

  19. 48 CFR 52.243-1 - Changes-Fixed-Price.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Changes-Fixed-Price. 52....243-1 Changes—Fixed-Price. As prescribed in 43.205(e), insert the following clause: Changes—Fixed-Price (AUG 1987) (a) The Contracting Officer may at any time, by written order, and without notice to...

  20. 18 CFR 367.2430 - Account 243, Obligations under capital leases-Current.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Liabilities § 367.2430... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account 243, Obligations under capital leases-Current. 367.2430 Section 367.2430 Conservation of Power and Water Resources...

  1. 26 CFR 1.243-4 - Qualifying dividends.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... section 243(b) (2) is effective for such taxable years. Since $10,000 of the February 1, 1966... exemption election is effective for such year, $10,000 of the distribution does not satisfy the condition... from Y's current year's earnings and profits (1969) $10,000 (b) Dividend from earnings and profits of Z...

  2. Clustering, Dimensionality Reduction, and Side Information

    DTIC Science & Technology

    2006-01-01

    Steinhaus in 1955 [243], Lloyd in 1957 [174], and MacQueen in 1967 [178]. The ISODATA algorithm by Ball and Hall in 1965 [8] can be regarded as an adaptive...1958. [242] R.R. Sokal and P.H.A. Sneath. Principles of Numerical Taxonomy. San Francisco, W. H. Freeman, 1963. [243] H. Steinhaus . Sur la division

  3. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be the...

  4. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be the...

  5. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be the...

  6. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be the...

  7. 49 CFR 372.243 - Controlling distances and population data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Controlling distances and population data. 372.243... population data. In the application of § 372.241: (a) Air-line distances or mileages about corporate limits of municipalities shall be used. (b) The population of any municipality shall be deemed to be the...

  8. 75 FR 68698 - Airworthiness Directives; Airbus Model A330-201, -202, -203, -223, -223F, -243, and -243F...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    .... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...

  9. 5 CFR 532.243 - Consultation with the agency wage committee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.243 Consultation with the agency wage... survey; (2) The report and recommendations of the local wage survey committee concerning the use of data... recommendation for a proposed wage schedule derived from the data. [46 FR 21344, Apr. 10, 1981. Redesignated at...

  10. 25 CFR 243.10 - How does the Paperwork Reduction Act affect this rule?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does the Paperwork Reduction Act affect this rule... REINDEER IN ALASKA § 243.10 How does the Paperwork Reduction Act affect this rule? The actions in this rule... information unless it displays a currently valid OMB control number. ...

  11. A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness

    PubMed Central

    Lee, Sung-Hun; Chen, Tsai-Yu; Dhar, Shilpa S.; Gu, Bingnan; Chen, Kaifu; Kim, Young Zoon; Li, Wei; Lee, Min Gyu

    2016-01-01

    Self-renewal and pluripotency are two fundamental characteristics of embryonic stem cells (ESCs) and are controlled by diverse regulatory factors, including pluripotent factors, epigenetic regulators and microRNAs (miRNAs). Although histone methyltransferases are key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs and the core pluripotent factor system to regulate ESC stemness is little known. Here, we show that the protein arginine methyltransferase 7 (PRMT7) is a pluripotent factor essential for the stemness of mouse ESCs. PRMT7 repressed the miR-24-2 gene encoding miR-24-3p and miR-24-2-5p by upregulating the levels of symmetrically dimethylated H4R3. Notably, miR-24-3p targeted the 3′ untranslated regions (UTRs) of the major pluripotent factors Oct4, Nanog, Klf4 and c-Myc, whereas miR-24-2-5p silenced Klf4 and c-Myc expression. miR-24-3p and miR-24-2-5p also targeted the 3′UTR of their repressor gene Prmt7. miR-24-3p and miR-24-2-5p induced mouse ESC differentiation, and their anti-sense inhibitors substantially reversed spontaneous differentiation of PRMT7-depleted mouse ESCs. Oct4, Nanog, Klf4 and c-Myc positively regulated Prmt7 expression. These findings define miR-24-3p and miR-24-2-5p as new anti-pluripotent miRNAs and also reveal a novel epigenetic stemness-regulatory mechanism in which a double-negative feedback loop consisting of PRMT7 and miR-24-3p/miR24-2-5p interplays with Oct4, Nanog, Klf4 and c-Myc to control ESC stemness. PMID:27625395

  12. A feedback loop comprising PRMT7 and miR-24-2 interplays with Oct4, Nanog, Klf4 and c-Myc to regulate stemness.

    PubMed

    Lee, Sung-Hun; Chen, Tsai-Yu; Dhar, Shilpa S; Gu, Bingnan; Chen, Kaifu; Kim, Young Zoon; Li, Wei; Lee, Min Gyu

    2016-12-15

    Self-renewal and pluripotency are two fundamental characteristics of embryonic stem cells (ESCs) and are controlled by diverse regulatory factors, including pluripotent factors, epigenetic regulators and microRNAs (miRNAs). Although histone methyltransferases are key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs and the core pluripotent factor system to regulate ESC stemness is little known. Here, we show that the protein arginine methyltransferase 7 (PRMT7) is a pluripotent factor essential for the stemness of mouse ESCs. PRMT7 repressed the miR-24-2 gene encoding miR-24-3p and miR-24-2-5p by upregulating the levels of symmetrically dimethylated H4R3. Notably, miR-24-3p targeted the 3' untranslated regions (UTRs) of the major pluripotent factors Oct4, Nanog, Klf4 and c-Myc, whereas miR-24-2-5p silenced Klf4 and c-Myc expression. miR-24-3p and miR-24-2-5p also targeted the 3'UTR of their repressor gene Prmt7 miR-24-3p and miR-24-2-5p induced mouse ESC differentiation, and their anti-sense inhibitors substantially reversed spontaneous differentiation of PRMT7-depleted mouse ESCs. Oct4, Nanog, Klf4 and c-Myc positively regulated Prmt7 expression. These findings define miR-24-3p and miR-24-2-5p as new anti-pluripotent miRNAs and also reveal a novel epigenetic stemness-regulatory mechanism in which a double-negative feedback loop consisting of PRMT7 and miR-24-3p/miR24-2-5p interplays with Oct4, Nanog, Klf4 and c-Myc to control ESC stemness. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  13. Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma.

    PubMed

    Sung, Chang Ohk; Choi, Chel Hun; Ko, Young-Hyeh; Ju, Hyunjeong; Choi, Yoon-La; Kim, Nyunsu; Kang, So Young; Ha, Sang Yun; Choi, Kyusam; Bae, Duk-Soo; Lee, Jeong-Won; Kim, Tae-Joong; Song, Sang Yong; Kim, Byoung-Gie

    2013-05-01

    Ovarian clear cell adenocarcinoma (Ov-CCA) is a distinctive subtype of ovarian epithelial carcinoma. In this study, we performed array comparative genomic hybridization (aCGH) and paired gene expression microarray of 19 fresh-frozen samples and conducted integrative analysis. For the copy number alterations, significantly amplified regions (false discovery rate [FDR] q <0.05) were 1q21.3 and 8q24.3, and significantly deleted regions were 3p21.31, 4q12, 5q13.2, 5q23.2, 5q31.1, 7p22.1, 7q11.23, 8p12, 9p22.1, 11p15.1, 12p13.31, 15q11.2, 15q21.2, 18p11.31, and 22q11.21 using the Genomic Identification of Significant Targets in Cancer (GISTIC) analysis. Integrative analysis revealed 94 genes demonstrating frequent copy number alterations (>25% of samples) that correlated with gene expression (FDR <0.05). These genes were mainly located on 8p11.21, 8p21.2-p21.3, 8q22.1, 8q24.3, 17q23.2-q23.3, 19p13.3, and 19p13.11. Among the regions, 8q24.3 was found to contain the most genes (30 of 94 genes) including PTK2. The 8q24.3 region was indicated as the most significant region, as supported by copy number, GISTIC, and integrative analysis. Pathway analysis using differentially expressed genes on 8q24.3 revealed several major nodes, including PTK2. In conclusion, we identified a set of 94 candidate genes with frequent copy number alterations that correlated with gene expression. Specific chromosomal alterations, such as the 8q24.3 gain containing PTK2, could be a therapeutic target in a subset of Ov-CCAs. Copyright © 2013. Published by Elsevier Inc.

  14. Effect of a beta-3 agonist on food intake in two strains of rats that differ in susceptibility to obesity.

    PubMed

    White, Christy L; Ishihara, Yuri; Dotson, Travis L; Hughes, David A; Bray, George A; York, David A

    2004-09-15

    Beta-3 agonists acutely reduce food intake, but the mechanism is not well understood. To evaluate the effect of a beta3 agonist on food intake in two strains of rats that differ in their sensitivity to becoming obese while eating a high-fat (HF) diet. Male Osborne-Mendel (OM) and S5B/Pl (S5B) rats were treated with a beta3-adrenergic agonist (CL 316,243) at 8 weeks of age, after an adaptation to either an HF (56% fat energy) or a low-fat (LF; 10% fat energy) diet that was equicaloric for protein (24% energy). Ad-lib-fed rats were injected intraperitoneally with CL 316,243, at doses of 0.03, 0.1, 0.3, 1.0 or 3.0 mg/kg, or with vehicle at the beginning of the dark cycle. Food intake was measured at 1, 3, 6 and 24 h after injections. The beta3 agonist CL 316,243 significantly decreased food intake at all timepoints in both strains of rats eating both diets. However, this inhibition of food intake was significantly greater in the S5B rat. CL 316,243 significantly decreased serum leptin and serum glucose in both the OM and the S5B rats, and again, the inhibition was greater in the S5B rat. Whereas CL 316,243 increased serum insulin levels in the OM rat, it decreased them in the S5B rat on an LF diet. In a second experiment, chow-fed rats were implanted with vascular ports into the jugular vein and allowed to recover. When CL 316,243 was injected into the animals that were fasted overnight, rats of both strains significantly increased their serum insulin at 30 min, but the increase was much more pronounced in the S5B rat. Serum glucose was decreased significantly at both the 30- and 60-min timepoints in the OM rat and at 30 min in the S5B rat. These experiments demonstrate that a beta3 agonist (CL 316,243) has a much greater effect in a strain of rats that resist fat-induced obesity.

  15. 26 CFR 1.535-3 - Accumulated earnings credit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... section 243(b)(3) and § 1.243-5 (relating to effect of 100-percent dividends received deduction under... way create an inference that an accumulation in excess of $150,000 ($100,000 in the case of taxable...,000 and that a deduction has been allowed under section 535(b)(6) in the amount of $5,000. Since the...

  16. 40 CFR 98.247 - Records that must be retained.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....246(b), and records of any annual average HHV calculations. (b) If you comply with the mass balance... in accordance with § 98.243(c)(4). (2) Start and end times and calculated carbon contents for time....243(c)(4) for determining carbon content of feedstock or product. (3) A part of the monitoring plan...

  17. 40 CFR 98.247 - Records that must be retained.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....246(b), and records of any annual average HHV calculations. (b) If you comply with the mass balance... in accordance with § 98.243(c)(4). (2) Start and end times and calculated carbon contents for time....243(c)(4) for determining carbon content of feedstock or product. (3) A part of the monitoring plan...

  18. 40 CFR 98.247 - Records that must be retained.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....246(b), and records of any annual average HHV calculations. (b) If you comply with the mass balance... in accordance with § 98.243(c)(4). (2) Start and end times and calculated carbon contents for time....243(c)(4) for determining carbon content of feedstock or product. (3) A part of the monitoring plan...

  19. 77 FR 6411 - Training, Qualification, and Oversight for Safety-Related Railroad Employees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... equipment is in a service that constitutes a train movement under part 232 of this chapter; [and] (6... Administration 49 CFR Parts 214, 232, and 243 Training, Qualification, and Oversight for Safety-Related Railroad..., 232, and 243 [Docket No. FRA-2009-0033, Notice No. 1] RIN 2130-AC06 Training, Qualification, and...

  20. 76 FR 63159 - Airworthiness Directives; Airbus Model A330-243F Airplanes Equipped With Rolls Royce Trent 700...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... Airworthiness Directives; Airbus Model A330-243F Airplanes Equipped With Rolls Royce Trent 700 Series Engines... Branch, ANM-116, Transport Airplane Directorate, FAA, 1601 Lind Avenue, SW., Renton, Washington 98057... assemblies and along the beam structure of the right and left engine thrust reversers, detailed inspection...

  1. Global-scale patterns of forest fragmentation

    Treesearch

    Kurt H. Riitters; James D. Wickham; R. O' Neill; B. Jones; E. Smith

    2000-01-01

    We report an analysis of forest fragmentation based on 1-km resolution land-cover maps for the globe. Measurements in analysis windows from 81 km 2 (9 x 9 pixels, "small" scale) to 59,049 km 2 (243 x 243 pixels, "large" scale) were used to characterize the fragmentation around each forested pixel. We identified six categories of fragmentation (...

  2. 5 CFR 531.243 - Promotion of a GM employee.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Promotion of a GM employee. 531.243... Promotion of a GM employee. (a) Upon promotion, an employee's status as a GM employee ends, as provided in § 531.241(b). (b) When an employee loses status as a GM employee because of a temporary promotion and is...

  3. Efficacy of triclosan-based toothpastes in the prevention and treatment of plaque-induced periodontal and peri-implant diseases.

    PubMed

    Trombelli, L; Farina, R

    2013-03-01

    To evaluate the efficacy of triclosan (T)-based toothpaste formulations in the prevention and treatment of plaque-induced periodontal and peri-implant diseases. A review of the existing literature was conducted with a systematic approach in order to retrieve pertinent articles. i) Compared with a control fluoride dentifrice, a fluoride dentifrice containing T formulations provides a more effective level of plaque control and gingival health in patients affected by gingivitis; ii) 0.3% T/2% copolymer/0.243% NaF formulation and 0.3% T/0.13% Ca glicerophosphate/1000 ppm F toothpaste in a natural Ca carbonate base seem the most effective T-based toothpaste formulations in controlling plaque and gingival inflammation in patients with gingivitis or mild/moderate periodontitis over a 6-month period; iii) 0.3% T/2% copolymer/0.243% NaF toothpaste formulation can reduce clinical attachment loss in young adolescents when compared with a 0.243% NaF toothpaste formulation, the magnitude of the difference being greater for patients with deep periodontal pockets at baseline; iv) 0.3% T/2% copolymer/0.243% NaF toothpaste formulation is either similarly or more efficacious in preventing the progression/recurrence of periodontal destruction when compared to a conventional fluoride toothpaste; v) 0.3% T/2% copolymer/0.243% NaF toothpaste formulation seems to be more effective than a fluoride toothpaste formulation in controlling the severity of mucosal inflammation, the incidence of mucosal bleeding as well as reducing probing pocket depth around dental implants.

  4. Functional properties and structural requirements of the plasmid pMV158-encoded MobM relaxase domain.

    PubMed

    Fernández-López, Cris; Pluta, Radoslaw; Pérez-Luque, Rosa; Rodríguez-González, Lorena; Espinosa, Manuel; Coll, Miquel; Lorenzo-Díaz, Fabián; Boer, D Roeland

    2013-07-01

    A crucial element in the horizontal transfer of mobilizable and conjugative plasmids is the relaxase, a single-stranded endonuclease that nicks the origin of transfer (oriT) of the plasmid DNA. The relaxase of the pMV158 mobilizable plasmid is MobM (494 residues). In solution, MobM forms a dimer through its C-terminal domain, which is proposed to anchor the protein to the cell membrane and to participate in type 4 secretion system (T4SS) protein-protein interactions. In order to gain a deeper insight into the structural MobM requirements for efficient DNA catalysis, we studied two endonuclease domain variants that include the first 199 or 243 amino acid residues (MobMN199 and MobMN243, respectively). Our results confirmed that the two proteins behaved as monomers in solution. Interestingly, MobMN243 relaxed supercoiled DNA and cleaved single-stranded oligonucleotides harboring oriTpMV158, whereas MobMN199 was active only on supercoiled DNA. Protein stability studies using gel electrophoresis and mass spectrometry showed increased susceptibility to degradation at the domain boundary between the N- and C-terminal domains, suggesting that the domains change their relative orientation upon DNA binding. Overall, these results demonstrate that MobMN243 is capable of nicking the DNA substrate independently of its topology and that the amino acids 200 to 243 modulate substrate specificity but not the nicking activity per se. These findings suggest that these amino acids are involved in positioning the DNA for the nuclease reaction rather than in the nicking mechanism itself.

  5. 76 FR 56286 - Airworthiness Directives; Airbus Model A330-201, -202, -203, -223, and -243 Airplanes, Model A330...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Airworthiness Directives; Airbus Model A330-201, -202, -203, - 223, and -243 Airplanes, Model A330-300 Series Airplanes, Model A340- 200 Series Airplanes, and Model A340-300 Series Airplanes AGENCY: Federal Aviation... A340-200/-300 aeroplanes. An extended de-bonding, if not detected and corrected, may degrade the...

  6. 76 FR 24832 - Airworthiness Directives; Airbus Model A330-201, -202, -203, -223, and -243 Airplanes, A330-300...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ...-201, -202, -203, - 223, and -243 Airplanes, A330-300 Series Airplanes, A340-200 Series Airplanes, and A340-300 Series Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of... some rudders fitted on A330 and A340-200/-300 aeroplanes. An extended de-bonding, if not detected and...

  7. 77 FR 39181 - Revisions to the California State Implementation Plan, Mojave Desert Air Quality Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... Register on February 28, 2012 and concern glass furnaces and biomass boilers. We are approving local rules... MDAQMD 1165 Glass Melting Furnaces......... 08/12/08 12/23/08 YSAQMD 2.43 Biomass Boilers 11/10/10 04/05.... * * * * * (388) * * * (i) * * * (F) Yolo-Solano Air Quality Management District. (1) Rule 2.43, ``Biomass Boilers...

  8. 19 CFR 24.3a - CBP bills; interest assessment on bills; delinquency; notice to principal and surety.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false CBP bills; interest assessment on bills... PROCEDURE § 24.3a CBP bills; interest assessment on bills; delinquency; notice to principal and surety. (a) Due date of CBP bills. CBP bills for supplemental duties, taxes and fees(increased or additional...

  9. 19 CFR 24.3a - CBP bills; interest assessment on bills; delinquency; notice to principal and surety.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false CBP bills; interest assessment on bills... PROCEDURE § 24.3a CBP bills; interest assessment on bills; delinquency; notice to principal and surety. (a) Due date of CBP bills. CBP bills for supplemental duties, taxes and fees(increased or additional...

  10. Analysis of a Partial Male-Sterile Mutant of Arabidopsis thaliana Isolated from a Low-Energy Argon Ion Beam Mutagenized Pool

    NASA Astrophysics Data System (ADS)

    Xu, Min; Bian, Po; Wu, Yuejin; Yu, Zengliang

    2008-04-01

    A screen for Arabidopsis fertility mutants, mutagenized by low-energy argon ion beam, yielded two partial male-sterile mutants tc243-1 and tc243-2 which have similar phenotypes. tc243-2 was investigated in detail. The segregation ratio of the mutant phenotypes in the M2 pools suggested that mutation behaved as single Mendelian recessive mutations. tc243 showed a series of mutant phenotypes, among which partial male-sterile was its striking mutant characteristic. Phenotype analysis indicates that there are four factors leading to male sterility. a. Floral organs normally develop inside the closed bud, but the anther filaments do not elongate sufficiently to position the locules above the stigma at anthesis. b. The anther locules do not dehisce at the time of flower opening (although limited dehiscence occurs later). c. Pollens of mutant plants develop into several types of pollens at the trinucleated stage, as determined by staining with DAPI (4',6-diamidino-2-phenylindole), which shows a variable size, shape and number of nucleus. d. The viability of pollens is lower than that of the wild type on the germination test in vivo and vitro.

  11. SeisCORK Engineering Design Study

    DTIC Science & Technology

    2006-05-01

    Stephen, R. A., et al. (1994a), The seafloor borehole array seismic system (SEABASS) and VLF ambient noise, Marine Geophysical Researches, 16, 243...286. Stephen, R. A., et al. (1994b), The Seafloor Borehole Array Seismic System (SEABASS) and VLF Ambient Noise, Marine Geophysical Researches, 16, 243...Contents Executive Summary 4 Introduction 5 General Science Goals and Justification for Borehole Seismology in the Seafloor 6 Validating Surface Seismic

  12. Bulk density of asteroid 243 Ida from the orbit of its satellite Dactyl

    USGS Publications Warehouse

    Belton, M.J.S.; Chapmant, C.R.; Thomas, P.C.; Davies, M.E.; Greenberg, R.; Klaasen, K.; Byrnes, D.; D'Amario, L.; Synnott, S.; Johnson, T.V.; McEwen, A.; Merline, W.J.; Davis, D.R.; Petit, J.-M.; Storrs, A.; Veverka, J.; Zellner, B.

    1995-01-01

    DURING its reconnaissance of the asteroid 243 Ida, the Galileo spacecraft returned images of a second object, 1993(243)1 Dactyl1 - the first confirmed satellite of an asteroid. Sufficient data were obtained on the motion of Dactyl to determine its orbit as a function of Ida's mass. Here we apply statistical and dynamical arguments to constrain the range of possible orbits, and hence the mass of Ida. Combined with the volume of Ida2, this yields a bulk density of 2.6??0.5 g cm-3. Allowing for the uncertainty in the porosity of Ida, this density range is consistent with a bulk chondritic composition, and argues against some (but not all) classes of meteoritic igneous rock types that have been suggested as compositionally representative of S-type asteroids like Ida.

  13. Bulk density of asteroid 243 Ida from the orbit of its satellite Dactyl

    USGS Publications Warehouse

    Belton, M.J.S.; Chapman, C.R.; Thomas, P.C.; Davies, M.E.; Greenberg, R.; Klaasen, K.; Byrnes, D.; D'Amario, L.; Synnott, S.; Johnson, T.V.; McEwen, A.; Merline, W.J.; Davis, D.R.; Petit, J.-M.; Storrs, A.; Veverka, J.; Zellner, B.

    1995-01-01

    DURING its reconnaissance of the asteroid 243 Ida, the Galileo spacecraft returned images of a second object, 1993(243)1 Dactyl1 - the first confirmed satellite of an asteroid. Sufficient data were obtained on the motion of Dactyl to determine its orbit as a function of Ida's mass. Here we apply statistical and dynamical arguments to constrain the range of possible orbits, and hence the mass of Ida. Combined with the volume of Ida2, this yields a bulk density of 2.6 ?? 0.5 g cm-3. Allowing for the uncertainty in the porosity of Ida, this density range is consistent with a bulk chon-dritic composition, and argues against some (but not all) classes of meteoritic igneous rock types that have been suggested as compositionally representative of S-type asteroids like Ida. ?? 2002 Nature Publishing Group.

  14. Genetic and Hormonal Risk Factors for Cancer in African American Men

    DTIC Science & Technology

    2006-05-01

    rs2740574 CYP3A4 7q21.1 5’ UTR (-293) G to A 49.6 46.8 rs700519 CYP19 15q21.1 Exon 6 (codon 264) C to T 30.1 30.8 rs9282858 SDR5A2 2p23 Exon 1...HSD17B2 Months 12-24 CYP19 CYP3A4 IGF1 We had initially planned to perform our SNP assays using either ABI PRISM® 7700 Sequence Detection...31.4 rs6163 CYP17 10q24.3 Exon 1 (Codon 65) G to T 57.9 66.4 rs6162 CYP17 10q24.3 Exon 1 (Codon 46) C to T 58.7 66.9 rs743572 CYP17 10q24.3 5’-UTR

  15. 29 CFR 779.243 - Goods that have been “produced for commerce by any person.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Goods that have been âproduced for commerce by any person.â... Moved in Or Produced for Commerce by Any Person § 779.243 Goods that have been “produced for commerce by... that have been “produced for commerce by any person” within the meaning of section 3(s), if he is...

  16. 29 CFR 779.243 - Goods that have been “produced for commerce by any person.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Goods that have been âproduced for commerce by any person.â... Moved in Or Produced for Commerce by Any Person § 779.243 Goods that have been “produced for commerce by... that have been “produced for commerce by any person” within the meaning of section 3(s), if he is...

  17. 29 CFR 779.243 - Goods that have been “produced for commerce by any person.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Goods that have been âproduced for commerce by any person.â... Moved in Or Produced for Commerce by Any Person § 779.243 Goods that have been “produced for commerce by... that have been “produced for commerce by any person” within the meaning of section 3(s), if he is...

  18. 29 CFR 779.243 - Goods that have been “produced for commerce by any person.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Goods that have been âproduced for commerce by any person.â... Moved in Or Produced for Commerce by Any Person § 779.243 Goods that have been “produced for commerce by... that have been “produced for commerce by any person” within the meaning of section 3(s), if he is...

  19. 29 CFR 779.243 - Goods that have been “produced for commerce by any person.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Goods that have been âproduced for commerce by any person.â... Moved in Or Produced for Commerce by Any Person § 779.243 Goods that have been “produced for commerce by... that have been “produced for commerce by any person” within the meaning of section 3(s), if he is...

  20. Electron flow in large metallomacromolecules and electronic switch of nanoparticle stabilization: new click ferrocenyl dentromers that reduce Au(III) to Au nanoparticles.

    PubMed

    Astruc, Didier; Wang, Qi; Fu, Fangyu; Martinez-Villacorta, Angel M; Moya, Sergio; Salmon, Lionel; Ruiz, Jaime; Hunel, Julien; Vax, Amélie

    2018-06-04

    Click ferrocenyl-terminal dentromers, a family of arene-cored dendrimers with triple branching (9-Fc, 27-Fc, 81-Fc and 243-Fc) reduce Au(III) to ferricinium dentromer-stabilized Au nanoparticles (AuNPs). Cyclic voltammetry studies in CH2Cl2 show reversible CV waves with some adsorption for the 243-Fc dentromer and a number of redox groups found, 255 ± 25, using the Bard-Anson method, close to the theoretical number of 243. The dentromers reduce aqueous HAuCl4 to water-soluble ferricinium chloride dentromer-stabilized gold nanoparticles (AuNPs) with core sizes between 30 and 47 nm. These triazolylferricinium dentromer-stabilized AuNPs are reduced by cobaltocene to cobalticinium chloride and ferrocene dentromer-weakly stabilized AuNPs together with red shift of the AuNP plasmon. The weakness of the AuNP stabilization is characterized by dentromer extraction with CH2Cl2 along with irreversible AuNP agglomeration for the 9, 27 and 81-ferrocenyl dentromer, only the 243-ferrocenyl dentromer-AuNP withstanding this process. Altogether this demonstrates the electronic switch of the dentromer-mediated AuNP stabilization. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. 40 CFR 721.10356 - Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-. 721.10356 Section 721.10356 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific...

  2. 40 CFR 721.10356 - Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-. 721.10356 Section 721.10356 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific...

  3. 40 CFR 721.10356 - Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Zinc, bis[3-(acetyl-.kappa.O)-6-methyl-2H-pyran-2,4(3H)-dionato-.kappa.O4]diaqua-. 721.10356 Section 721.10356 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific...

  4. Statistical properties of Pu 243 , and Pu 242 ( n , γ ) cross section calculation

    DOE PAGES

    Laplace, T. A.; Zeiser, F.; Guttormsen, M.; ...

    2016-01-29

    The level density and γ-ray strength function (γSF) of 243Pu have been measured in the quasicontinuum using the Oslo method. Excited states in 243Pu were populated using the 242Pu(d,p) reaction. The level density closely follows the constant-temperature level density formula for excitation energies above the pairing gap. The γSF displays a double-humped resonance at low energy as also seen in previous investigations of actinide isotopes. The structure is interpreted as the scissors resonance and has a centroid of ω SR = 2.42(5) MeV and a total strength of B SR = 10.1(15) μ 2 N, which is in excellent agreementmore » with sum-rule estimates. Lastly, the measured level density and γSF were used to calculate the 242Pu(n,γ) cross section in a neutron energy range for which there were previously no measured data.« less

  5. [Etiological analysis and establishment of a discriminant model for lower respiratory tract infections in hospitalized patients].

    PubMed

    Chen, Y S; Lin, X H; Li, H R; Hua, Z D; Lin, M Q; Huang, W S; Yu, T; Lyu, H Y; Mao, W P; Liang, Y Q; Peng, X R; Chen, S J; Zheng, H; Lian, S Q; Hu, X L; Yao, X Q

    2017-12-12

    Objective: To analyze the pathogens of lower respiratory tract infection(LRTI) including bacterial, viral and mixed infection, and to establish a discriminant model based on clinical features in order to predict the pathogens. Methods: A total of 243 hospitalized patients with lower respiratory tract infections were enrolled in Fujian Provincial Hospital from April 2012 to September 2015. The clinical data and airway (sputum and/or bronchoalveolar lavage) samples were collected. Microbes were identified by traditional culture (for bacteria), loop-mediated isothermal amplification(LAMP) and gene sequencing (for bacteria and atypical pathogen), or Real-time quantitative polymerase chain reaction (Real-time PCR)for viruses. Finally, a discriminant model was established by using the discriminant analysis methods to help to predict bacterial, viral and mixed infections. Results: Pathogens were detected in 53.9% (131/243) of the 243 cases.Bacteria accounted for 23.5%(57/243, of which 17 cases with the virus, 1 case with Mycoplasma pneumoniae and virus), mainly Pseudomonas Aeruginosa and Klebsiella Pneumonia. Atypical pathogens for 4.9% (12/243, of which 3 cases with the virus, 1 case of bacteria and viruses), all were mycoplasma pneumonia. Viruses for 34.6% (84/243, of which 17 cases of bacteria, 3 cases with Mycoplasma pneumoniae, 1 case with Mycoplasma pneumoniae and bacteria) of the cases, mainly Influenza A virus and Human Cytomegalovirus, and other virus like adenovirus, human parainfluenza virus, respiratory syncytial virus, human metapneumovirus, human boca virus were also detected fewly. Seven parameters including mental status, using antibiotics prior to admission, complications, abnormal breath sounds, neutrophil alkaline phosphatase (NAP) score, pneumonia severity index (PSI) score and CRUB-65 score were enrolled after univariate analysis, and discriminant analysis was used to establish the discriminant model by applying the identified pathogens as the dependent variable. The total positive predictive value was 64.7%(77/119), with 66.7% for bacterial infection, 78.0% for viral infection and 33.3% for the mixed infection. Conclusions: The mostly detected pathogens were Pseudomonas aeruginosa, atypitcal pathogens, Klebsiella pneumoniae, influenza A virus and human cytomegalovirus in hospitalized patients with LRTI in this hospital. The discriminant diagnostic model established by clinical features may contribute to predict the pathogens of LRTI.

  6. Creating and Manipulating Formalized Software Architectures to Support a Domain-Oriented Application Composition System

    DTIC Science & Technology

    1992-12-01

    OOD) Paradigm ...... .... 2-7 2.4.3 Feature-Oriented Domain Analysis ( FODA ) ..... 2-7 2.4.4 Hierarchical Software Systems .................. 2-7...domain analysis ( FODA ) is one approach to domain analysis whose primary goal is to make domain products reusable (20:47). A domain model describes 2-5...7), among others. 2.4.3 Feature-Oriented Domain Analysis ( FODA ) Kang and others used the com- plete FODA methodology to successfully develop a window

  7. Selenocysteine Positional Variants Reveal Contributions to Copper Binding From Cysteine Residues in Domains 2 And 3 of Human Copper Chaperone for Superoxide Dismutase

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barry, A.N.; Clark, K.M.; Otoikhian, A.

    2009-05-11

    The human copper chaperone for superoxide dismutase binds copper both in an Atx1-like MTCQSC motif in domain 1 and via a multinuclear cluster formed by two CXC motifs at the D3 dimer interface. The composition of the Cu(I) cluster has been investigated previously by mutagenesis of the CXC motif, and by construction of a CXU selenocysteine derivative, which has permitted XAS studies at both Cu and Se absorption edges. Here, we report the semisynthesis and spectroscopic characterization of a series of derivatives with the sequences 243-CACA, 243-CAUA, 243-UACA, and 243-UAUA in the D1 double mutant (C22AC25A) background, prepared by expressedmore » protein ligation of Sec-containing tetrapeptides to an hCCS-243 truncation. By varying the position of the Se atom in the CXC motif, we have been able to show that Se is always bridging (2 Se-Cu) rather than terminal (1 Se-Cu). Substitution of both D3 Cys residues by Sec in the UAUA variant does not eliminate the Cu-S contribution, confirming our previous description of the cluster as most likely a Cu{sub 4}S{sub 6} species, and suggesting that D2 Cys residues contribute to the cluster. As predicted by this model, when Cys residues C141, C144, and C227 are mutated to alanine either individually or together as a triple mutant, the cluster nuclearity is dramatically attenuated. These data suggest that Cys residues in D2 of hCCS are involved in the formation, stability, and redox potential of the D3 cluster. The significance of these finding to the SOD1 thiol/disulfide oxidase activity are discussed in terms of a model in which a similar multinuclear cluster may form in the CCS-SOD heterodimer.« less

  8. Episiotomy and the risk of severe perineal injuries among Korean women.

    PubMed

    Kwon, Ha Yan; Park, Hyun Soo

    2017-07-01

    We examined the frequency of severe perineal injuries according to the use of episiotomy in vaginal deliveries of Korean women. This is a retrospective cohort study in which 358 consecutive parturients were included. Women were divided into episiotomy (n = 115) and no episiotomy (n = 243) groups. The main outcome was the occurrence of severe (third or fourth degree) perineal injuries. Delivery records and medical documents were reviewed to collect the data. Parametric and nonparametric tests were used as appropriate. There were no significant differences in the frequency of severe perineal injuries between two groups (6.1% (7/115) in episiotomy versus 3.7% (9/243) in no episiotomy group, p = 0.308). Anterior perineal laceration was more frequent (40.3% (98/243) vs. 18.3% (21/115), p < 0.001), but intact perineum was found in 15.6% (38/243) of women in no episiotomy group. Logistic regression analysis was performed to evaluate independent risk factors in the occurrence of severe perineal injuries including maternal age, parity, performance of episiotomy, head position at delivery, length of second stage of labor, birth weight, head circumference, and the use of vacuum during delivery. Only birthweight was a significant factor in predicting severe perineal injuries, and performance of episiotomy did not increase nor decrease the risk of severe perineal injury. There was no difference in the occurrence of severe perineal injuries according to the use of episiotomy.

  9. Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.

    PubMed

    Zagórska, Agnieszka; Bucki, Adam; Kołaczkowski, Marcin; Siwek, Agata; Głuch-Lutwin, Monika; Starowicz, Gabriela; Kazek, Grzegorz; Partyka, Anna; Wesołowska, Anna; Słoczyńska, Karolina; Pękala, Elżbieta; Pawłowski, Maciej

    2016-01-01

    A series of 2-fluoro and 3-trifluoromethylphenylpiperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (4-21) were synthesized and evaluated for their serotonin (5-HT 1A /5-HT 7 ) receptor affinity and phosphodiesterase (PDE4B and PDE10A) inhibitor activity. The study enabled the identification of potent 5-HT 1A , 5-HT 7 and mixed 5-HT 1A /5-HT 7 receptor ligands with weak inhibitory potencies for PDE4B and PDE10A. The tests have been completed with the determination of lipophilicity and metabolic stability using micellar electrokinetic chromatography (MEKC) system and human liver microsomes (HLM) model. In preliminary pharmacological in vivo studies, selected compound 8-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-1,3,7-trimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (9) behaved as a potential antidepressant in forced swim test (FST) in mice. Moreover, potency of antianxiety effects evoked by 9 (2.5 mg/kg) is greater than that of the reference anxiolytic drug, diazepam. Molecular modeling revealed that fluorinated arylpiperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione have major significance for the provision of lead compounds for antidepressant and/or anxiolytic application.

  10. Backbone and sidechain methyl Ile (δ1), Leu and Val chemical shift assignments of RDE-4 (1-243), an RNA interference initiation protein in C. elegans.

    PubMed

    Chiliveri, Sai Chaitanya; Kumar, Sonu; Marelli, Udaya Kiran; Deshmukh, Mandar V

    2012-10-01

    The RNAi pathway of several organisms requires presence of double stranded RNA binding proteins for functioning of Dicer in gene regulation. In C. elegans, a double stranded RNA binding protein, RDE-4 (385 aa, 44 kDa) recognizes long exogenous dsRNA and initiates the RNAi pathway. We have achieved complete backbone and stereospecific methyl sidechain Ile (δ1), Leu and Val chemical shifts of first 243 amino acids of RDE-4, namely RDE-4ΔC.

  11. Neutron-induced fission cross section measurement of 233U, 241Am and 243Am in the energy range 0.5 MeV En 20 MeV at n TOF at CERN

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Belloni, F.; Milazzo, P. M.; Calviani, M.

    2012-01-01

    Neutron-induced fission cross section measurements of 233U, 243Am and 241Am relative to 235U have been carried out at the neutron time-of-flight facility n TOF at CERN. A fast ionization chamber has been employed. All samples were located in the same detector; therefore the studied elements and the reference 235U target are subject to the same neutron beam.

  12. Initial Assessment of β3-Adrenoceptor-Activated Brown Adipose Tissue in Streptozotocin-Induced Type 1 Diabetes Rodent Model Using [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

    PubMed

    Baranwal, Aparna; Mirbolooki, M Reza; Mukherjee, Jogeshwar

    2015-01-01

    Metabolic activity of brown adipose tissue (BAT) is activated by β3-adrenoceptor agonists and norepinephrine transporter (NET) blockers and is measurable using [(18)F]fluorodeoxyglucose ([(18)F]FDG) positron emission tomography/computed tomography (PET/CT) in rats. Using the streptozotocin (STZ)-treated rat model of type 1 diabetes mellitus (T1DM), we investigated BAT activity in this rat model under fasting and nonfasting conditions using [(18)F]FDG PET/CT. Drugs that enhance BAT activity may have a potential for therapeutic development in lowering blood sugar in insulin-resistant diabetes. Rats were rendered diabetic by administration of STZ and confirmed by glucose measures. [(18)F]FDG was injected in the rats (fasted or nonfasted) pretreated with either saline or β3-adrenoceptor agonist CL316,243 or the NET blocker atomoxetine for PET/CT scans. [(18)F]FDG metabolic activity was computed as standard uptake values (SUVs) in interscapular brown adipose tissue (IBAT) and compared across the different drug treatment conditions. Blood glucose levels > 500 mg/dL were established for the STZ-treated diabetic rats. Under fasting conditions, average uptake of [(18)F]FDG in the IBAT of STZ-treated diabetic rats was approximately 70% lower compared to that of normal rats. Both CL316,243 and atomoxetine activated IBAT in normal rats had an SUV > 5, whereas activation in STZ-treated rats was significantly lower. The agonist CL316,243 activated IBAT up to threefold compared to saline in the fasted STZ-treated rat. In the nonfasted rat, the IBAT activation was up by twofold by CL316243. Atomoxetine had a greater effect on lowering blood sugar levels compared to CL316,243 in the nonfasted rats. A significant reduction in metabolic activity was observed in the STZ-treated diabetic rodent model. Increased IBAT activity in the STZ-treated diabetic rat under nonfasted conditions using the β3-adrenoceptor agonist CL316,243 suggests a potential role of BAT in modulating blood sugar levels. Further studies are needed to evaluate the therapeutic role of β3-adrenoceptor agonists in insulin-resistant T1DM.

  13. Lack of Support for the Association Between GAD2 Polymorphisms andSevere Human Obesity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Swarbrick, Michael M.; Waldenmaier, Bjorn; Pennacchio, Len A.

    Demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention and treatment of these conditions. Unequivocal proof of such an association, however, requires adherence to established methodological guidelines, which include independent replication of initial positive findings. Recently, single nucleotide polymorphisms (SNPs) within GAD2 were found to be associated with class III obesity (BMI > 40 kg/m2) in 188 families (612 individuals) segregating the condition and a case-control study of 575 cases and 646 lean controls. Functional data supporting a pathophysiological role for one of the SNPs (-243A>G) weremore » also presented. In the present study, we attempted to replicate this association in larger groups of subjects, and to extend the functional studies of the -243A>G SNP. In 2,327 subjects comprising 692 German nuclear families with severe, early-onset obesity, we found no evidence for a relationship between the three GAD2 SNPs and obesity, whether SNPs were studied individually or as haplotypes. In two independent case-control studies (a total of 680 class III obesity cases and 1,186 lean controls), there was no significant relationship between the -243A>G SNP and obesity (odds ratio (OR) = 0.99, 95% CI 0.83 - 1.18,in the pooled sample). These negative findings were reinforced by a meta-analysis for the association between the 243G allele and class III obesity, which yielded an OR of 1.11 (95% CI 0.90 - 1.36) in a total sample of 1,252 class III obese cases and 1,800 lean controls. Finally,we were unable to confirm or extend the functional data pertaining to the -243A>G variant. Potential confounding variables in association studies involving common variants and complex diseases (low power to detect modest genetic effects, over-interpretation of marginal data, population stratification and biological plausibility) are also discussed in the context of GAD2 and severe obesity.« less

  14. Standards for Advisement, Invocation, and Waiver of Counsel in Military Intelligence Interrogations

    DTIC Science & Technology

    2004-04-01

    appointed counsel experienced 288 Id para. 86.1 289 Direccion Nacional contra el Terrorismo . 290 Id para. 86.2. 291 See id. (citing Decree-Law 25,744, art...60 (1st Cir. 2000) ( en banc); United States v. Zabenah, 837 F.2d 1249, 1261 (5th Cir. 1988); Goldstar v. United States, 967 F.2d 965, 968 (4th Cir...Jimenez-Nava, 243 F.3d at 195-98. 135 Jimenez-Nava, 243 F.3d at 198. See also United States v. Lombera-Camorlinga, 206 F.3d 882, 885 (9th Cir. 2000) ( en

  15. Aircraft measurement of radio frequency noise at 121.5 MHz, 243 MHz and 406 MHz

    NASA Technical Reports Server (NTRS)

    Taylor, R. E.; Hill, J. S.

    1977-01-01

    An airborne survey measurement of terrestrial radio-frequency noise over U.S. metropolitan areas was carried out at 121.5, 243 and 406 MHz with horizontal-polarization monopole antennas. Flights were at 25,000 feet altitude. Radio-noise measurements, expressed in equivalent antenna-noise temperature, indicate a steady-background noise temperature of 572,000 K, at 121.5 MHz, during daylight over New York City. This data is helpful in compiling radio-noise temperature maps; in turn useful for designing satellite-aided, emergency-distress search and rescue communication systems.

  16. First Galileo image of asteroid 243 Ida

    NASA Technical Reports Server (NTRS)

    Chapman, C. R.; Belton, M. J. S.; Veverka, J.; Neukum, G.; Head, J.; Greeley, Ronald; Klaasen, K.; Morrison, D.

    1994-01-01

    The second spacecraft encounter with an asteroid has yielded an unprecedentedly high resolution portrait of 243 Ida. On 28 Aug. 1993, Galileo obtained an extensive data set on this small member of the Koronis family. Most of the data recorded on the tape recorder will be returned to Earth in spring 1994. A five-frame mosaic of Ida was acquired with good illumination geometry a few minutes before closest approach; it has a resolution of 31 to 38 m/pixel amd was played back during Sept. 1993. Preliminary analyses of this single view of Ida are summarized.

  17. Analytical Chemistry Developmental Work Using a 243Am Solution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spencer, Khalil J.; Stanley, Floyd E.; Porterfield, Donivan R.

    2015-02-24

    This project seeks to reestablish our analytical capability to characterize Am bulk material and develop a reference material suitable to characterizing the purity and assay of 241Am oxide for industrial use. The tasks associated with this phase of the project included conducting initial separations experiments, developing thermal ionization mass spectrometry capability using the 243Am isotope as an isotope dilution spike , optimizing the spike for the determination of 241Pu- 241 Am radiochemistry, and, additionally, developing and testing a methodology which can detect trace to ultra- trace levels of Pu (both assay and isotopics) in bulk Am samples .

  18. Considerations for NATO Satellite Communications in the Post 2000 Era (Elements de Reflexion pour les Communications par Satellite dans les Pays Membres de l’OTAN apres l’An 2000),

    DTIC Science & Technology

    1991-06-01

    and Proliferated LEO Systems 243 10 6 Summary Evaluation 243 10.7 Candidate Architectures 244 108 References 245 Appendix 10A. Candidate Orbits for a... biTo develop potential SATCOM system configurations - Mid 1987 Coordination within NATO and including sub-system design issues issue of the Terms of...paragraphs above have been defined using different orbits (c) The systems (geostationary, polar, 12-24-hr inclined at 63’.4 and Low Earth Orbit LEO

  19. Selective Oxidation and Reactive Wetting During Hot-Dip Galvanizing of a 1.0 pct Al-0.5 pct Si TRIP-Assisted Steel

    NASA Astrophysics Data System (ADS)

    Bellhouse, E. M.; McDermid, J. R.

    2012-07-01

    Selective oxidation and reactive wetting during continuous galvanizing were studied for a low-alloy transformation induced plasticity (TRIP)-assisted steel with 0.2 pct C, 1.5 pct Mn, 1.0 pct Al and 0.5 pct Si. Three process atmospheres were tested during annealing prior to galvanizing: 220 K (-53 °C) dew point (dp) N2-20 pct H2, 243 K (-30 °C) dp N2-5 pct H2 and 278 K (+5 °C) dp N2-5 pct H2. The process atmosphere oxygen partial pressure affected the oxide chemistry, morphology and thickness. For the 220 K (-53 °C) dp and 243 K (-30 °C) dp process atmospheres, film and nodule-type manganese, silicon and aluminum containing oxides were observed at the surface. For the 278 K (+5 °C) dp atmosphere, MnO was observed at the grain boundaries and as thicker localized surface films. Oxide morphology, thickness and chemistry affected reactive wetting, with complete wetting being observed for the 220 K (-53 °C) dp and 243 K (-30 °C) dp process atmospheres and incomplete reactive wetting being observed for the 278 K (+5 °C) dp atmosphere. Complete reactive wetting for the 220 K (-53 °C) dp and 243 K (-30 °C) dp process atmospheres was attributed to a combination of zinc bridging of oxides, aluminothermic reduction of surface oxides and wetting of the oxides. Incomplete wetting for the 278 K (+5 °C) dp atmosphere was attributed to localized thick MnO films.

  20. Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.

    PubMed

    Gambacorti-Passerini, Carlo B; Donadoni, Carla; Parmiani, Andrea; Pirola, Alessandra; Redaelli, Sara; Signore, Giovanni; Piazza, Vincenzo; Malcovati, Luca; Fontana, Diletta; Spinelli, Roberta; Magistroni, Vera; Gaipa, Giuseppe; Peronaci, Marco; Morotti, Alessandro; Panuzzo, Cristina; Saglio, Giuseppe; Usala, Emilio; Kim, Dong-Wook; Rea, Delphine; Zervakis, Konstantinos; Viniou, Nora; Symeonidis, Argiris; Becker, Heiko; Boultwood, Jacqueline; Campiotti, Leonardo; Carrabba, Matteo; Elli, Elena; Bignell, Graham R; Papaemmanuil, Elli; Campbell, Peter J; Cazzola, Mario; Piazza, Rocco

    2015-01-15

    Despite the recent identification of recurrent SETBP1 mutations in atypical chronic myeloid leukemia (aCML), a complete description of the somatic lesions responsible for the onset of this disorder is still lacking. To find additional somatic abnormalities in aCML, we performed whole-exome sequencing on 15 aCML cases. In 2 cases (13.3%), we identified somatic missense mutations in the ETNK1 gene. Targeted resequencing on 515 hematological clonal disorders revealed the presence of ETNK1 variants in 6 (8.8%) of 68 aCML and 2 (2.6%) of 77 chronic myelomonocytic leukemia samples. These mutations clustered in a small region of the kinase domain, encoding for H243Y and N244S (1/8 H243Y; 7/8 N244S). They were all heterozygous and present in the dominant clone. The intracellular phosphoethanolamine/phosphocholine ratio was, on average, 5.2-fold lower in ETNK1-mutated samples (P < .05). Similar results were obtained using myeloid TF1 cells transduced with ETNK1 wild type, ETNK1-N244S, and ETNK1-H243Y, where the intracellular phosphoethanolamine/phosphocholine ratio was significantly lower in ETNK1-N244S (0.76 ± 0.07) and ETNK1-H243Y (0.37 ± 0.02) than in ETNK1-WT (1.37 ± 0.32; P = .01 and P = .0008, respectively), suggesting that ETNK1 mutations may inhibit the catalytic activity of the enzyme. In summary, our study shows for the first time the evidence of recurrent somatic ETNK1 mutations in the context of myeloproliferative/myelodysplastic disorders. © 2015 by The American Society of Hematology.

  1. Asteroid Ida and Its Moon

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This is the first full picture showing both asteroid 243 Ida and its newly discovered moon to be transmitted to Earth from the National Aeronautics and Space Administration's (NASA's) Galileo spacecraft--the first conclusive evidence that natural satellites of asteroids exist. Ida, the large object, is about 56 kilometers (35 miles) long. Ida's natural satellite is the small object to the right. This portrait was taken by Galileo's charge-coupled device (CCD) camera on August 28, 1993, about 14 minutes before the Jupiter-bound spacecraft's closest approach to the asteroid, from a range of 10,870 kilometers (6,755 miles). Ida is a heavily cratered, irregularly shaped asteroid in the main asteroid belt between Mars and Jupiter--the 243rd asteroid to be discovered since the first was found at the beginning of the 19th century. Ida is a member of a group of asteroids called the Koronis family. The small satellite, which is about 1.5 kilometers (1 mile) across in this view, has yet to be given a name by astronomers. It has been provisionally designated '1993 (243) 1' by the International Astronomical Union. ('1993' denotes the year the picture was taken, '243' the asteroid number and '1' the fact that it is the first moon of Ida to be found.) Although appearing to be 'next' to Ida, the satellite is actually in the foreground, slightly closer to the spacecraft than Ida is. Combining this image with data from Galileo's near-infrared mapping spectrometer, the science team estimates that the satellite is about 100 kilometers (60 miles) away from the center of Ida. This image, which was taken through a green filter, is one of a six-frame series using different color filters. The spatial resolution in this image is about 100 meters (330 feet) per pixel.

  2. CHARGE association in a child with de novo inv dup (14)(q22{yields}q24.3)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    North, K.; Wu, B.L.; Whiteman, D.

    1994-09-01

    The CHARGE association is an increasingly recognized complex of multiple malformations, that include Coloboma, Heart defect, choanal Atresia, Retardation of mental and somatic development, hypoplastic Genitalia, and Ear abnormalities or deafness. It has been postulated that many of the defects result from abnormalities in the development, migration or interaction of cells of the cephalic neural crest. The majority of cases are sporadic. We report a case of an inverted duplication (14)(q22{yields}q24.3) associated with CHARGE association. The patient was a 4 {1/2}-year-old female and was the product of a normal pregnancy. Family history was unremarkable. The clinical manifestations included the combinationmore » of congenital anomalies (coloboma, ventricular septal defect, severe developmental delay and growth retardation, genital hypoplasia and sensorineural deafness) in association with soft tissue choanal atresia, dysphagia, and minor dysmorphic features (low set ears, upslanting palpebral fissures). High resolution cytogenetic studies revealed that the child has 46,XX,inv dup(14)(q22{yields}q24.3) and parents have normal chromosomes. FISH with a chromosome 14 paint probe confirmed that the duplicated region is entirely derived from chromosome 14. FISH with D22S75 probe for region 22q11.2 detected no deletion for this locus. Several duplications or deletions involving different chromosomes have been reported for patients with conditions resembling CHARGE association. This indicates that CHARGE is possible genetically heterogenous, parallelling the phenotypic heterogeneity of the disorder. Two published cases with unbalanced rearrengements involving 14q22 have some comparable features with our case, which suggests that the locus for a gene causing some of the features of CHARGE association may reside at 14q22 or 14q24.3.« less

  3. Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2–p12.1 and two large chromosomal abnormalities at 16q22.3–q24.3 and Xq23–q28

    PubMed Central

    Rudd, Danielle; Axelsen, Michael; Epping, Eric A; Andreasen, Nancy; Wassink, Thomas

    2015-01-01

    Key Clinical Message Childhood-onset schizophrenia is rare, comprising 1% of known schizophrenia cases. Here, we report a patient with childhood-onset schizophrenia who has three large chromosomal abnormalities: an inherited 2.2 Mb deletion of chromosome 3p12.2–p12.1, a de novo 16.7 Mb duplication of 16q22.3–24.3, and a de novo 43 Mb deletion of Xq23–q28. PMID:25914809

  4. 3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

    PubMed

    Pittalà, Valeria; Romeo, Giuseppe; Salerno, Loredana; Siracusa, Maria Angela; Modica, Maria; Materia, Luisa; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana; Marucci, Gabriella; Angeli, Piero; Russo, Filippo

    2006-01-01

    The discovery of a new series of selective and high-affinity alpha(1)-adrenoceptor (alpha(1)-AR) ligands, characterized by a 1H-pyrrolo[2,3-d]-pyrimidine-2,4(3H,7H)-dione system, is described in this paper. Some synthesized compounds, including 20, 22, and 30, displayed affinity in the nanomolar range for alpha(1)-ARs and substantial selectivity with respect to 5-HT(1A) and dopaminergic D(1) and D(2) receptors. Functional assays, performed on selected derivatives, showed antagonistic properties.

  5. Management of paediatric periorbital cellulitis: Our experience of 243 children managed according to a standardised protocol 2012-2015.

    PubMed

    Crosbie, Robin A; Nairn, Jonathan; Kubba, Haytham

    2016-08-01

    Paediatric periorbital cellulitis is a common condition. Accurate assessment can be challenging and appropriate use of CT imaging is essential. We audited admissions to our unit over a four year period, with reference to CT scanning and adherence to our protocol. Retrospective audit of paediatric patients admitted with periorbital cellulitis, 2012-2015. Total of 243 patients included, mean age 4.7 years with slight male predominance, the median length of admission was 2 days. 48/243 (20%) underwent CT during admission, 25 (52%) of these underwent surgical drainage. As per protocol, CT brain performed with all orbital scans; no positive intracranial findings on any initial scan. Three children developed intracranial complications subsequently; all treated with antibiotics. Our re-admission rate within 30 days was 2.5%. Our audit demonstrates benefit of standardising practice and the low CT rate, with high percentage taken to theatre and no missed abscesses, supports the protocol. There may be an argument to avoid CT brain routinely in all initial imaging sequences in those children without neurological signs or symptoms. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. 2.43 kW narrow linewidth linearly polarized all-fiber amplifier based on mode instability suppression

    NASA Astrophysics Data System (ADS)

    Su, Rongtao; Tao, Rumao; Wang, Xiaolin; Zhang, Hanwei; Ma, Pengfei; Zhou, Pu; Xu, Xiaojun

    2017-08-01

    We demonstrate an experimental study on scaling mode instability (MI) threshold in fiber amplifiers based on fiber coiling. The experimental results show that coiling the active fiber in the cylindrical spiral shape is superior to the coiling in the plane spiral shape. When the polarization maintained Yb-doped fiber (PM YDF: with a core/inner-cladding diameter of 20/400 µm) is coiled on an aluminous plate with a bend diameter of 9-16 cm, the MI threshold is ~1.55 kW. When such a PM YDF is coiled on an aluminous cylinder with diameter of 9 cm, no MI is observed at the output power of 2.43 kW, which is limited by the available pump power. The spectral width and polarization extinction ratio is 0.255 nm and 18.3 dB, respectively, at 2.43 kW. To the best of our knowledge, this is the highest output power from a linear polarized narrow linewidth all-fiberized amplifier. By using a theoretical model, the potential MI-free scaling capability in such an amplifier is estimated to be 3.5 kW.

  7. Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.

    PubMed

    Dutca, Laura M; Stasheff, Steven F; Hedberg-Buenz, Adam; Rudd, Danielle S; Batra, Nikhil; Blodi, Frederick R; Yorek, Matthew S; Yin, Terry; Shankar, Malini; Herlein, Judith A; Naidoo, Jacinth; Morlock, Lorraine; Williams, Noelle; Kardon, Randy H; Anderson, Michael G; Pieper, Andrew A; Harper, Matthew M

    2014-12-02

    Traumatic brain injury (TBI) frequently leads to chronic visual dysfunction. The purpose of this study was to investigate the effect of TBI on retinal ganglion cells (RGCs), and to test whether treatment with the novel neuroprotective compound P7C3-S243 could prevent in vivo functional deficits in the visual system. Blast-mediated TBI was modeled using an enclosed over-pressure blast chamber. The RGC physiology was evaluated using a multielectrode array and pattern electroretinogram (PERG). Histological analysis of RGC dendritic field and cell number were evaluated at the end of the study. Visual outcome measures also were evaluated based on treatment of mice with P7C3-S243 or vehicle control. We show that deficits in neutral position PERG after blast-mediated TBI occur in a temporally bimodal fashion, with temporary recovery 4 weeks after injury followed by chronically persistent dysfunction 12 weeks later. This later time point is associated with development of dendritic abnormalities and irreversible death of RGCs. We also demonstrate that ongoing pathologic processes during the temporary recovery latent period (including abnormalities of RGC physiology) lead to future dysfunction of the visual system. We report that modification of PERG to provocative postural tilt testing elicits changes in PERG measurements that correlate with a key in vitro measures of damage: the spontaneous and light-evoked activity of RGCs. Treatment with P7C3-S243 immediately after injury and throughout the temporary recovery latent period protects mice from developing chronic visual system dysfunction. Provocative PERG testing serves as a noninvasive test in the living organism to identify early damage to the visual system, which may reflect corresponding damage in the brain that is not otherwise detectable by noninvasive means. This provides the basis for developing an earlier diagnostic test to identify patients at risk for developing chronic CNS and visual system damage after TBI at an earlier stage when treatments may be more effective in preventing these sequelae. In addition, treatment with the neuroprotective agent P7C3-S243 after TBI protects from visual system dysfunction after TBI. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

  8. Early Detection of Subclinical Visual Damage After Blast-Mediated TBI Enables Prevention of Chronic Visual Deficit by Treatment With P7C3-S243

    PubMed Central

    Dutca, Laura M.; Stasheff, Steven F.; Hedberg-Buenz, Adam; Rudd, Danielle S.; Batra, Nikhil; Blodi, Frederick R.; Yorek, Matthew S.; Yin, Terry; Shankar, Malini; Herlein, Judith A.; Naidoo, Jacinth; Morlock, Lorraine; Williams, Noelle; Kardon, Randy H.; Anderson, Michael G.; Pieper, Andrew A.; Harper, Matthew M.

    2014-01-01

    Purpose. Traumatic brain injury (TBI) frequently leads to chronic visual dysfunction. The purpose of this study was to investigate the effect of TBI on retinal ganglion cells (RGCs), and to test whether treatment with the novel neuroprotective compound P7C3-S243 could prevent in vivo functional deficits in the visual system. Methods. Blast-mediated TBI was modeled using an enclosed over-pressure blast chamber. The RGC physiology was evaluated using a multielectrode array and pattern electroretinogram (PERG). Histological analysis of RGC dendritic field and cell number were evaluated at the end of the study. Visual outcome measures also were evaluated based on treatment of mice with P7C3-S243 or vehicle control. Results. We show that deficits in neutral position PERG after blast-mediated TBI occur in a temporally bimodal fashion, with temporary recovery 4 weeks after injury followed by chronically persistent dysfunction 12 weeks later. This later time point is associated with development of dendritic abnormalities and irreversible death of RGCs. We also demonstrate that ongoing pathologic processes during the temporary recovery latent period (including abnormalities of RGC physiology) lead to future dysfunction of the visual system. We report that modification of PERG to provocative postural tilt testing elicits changes in PERG measurements that correlate with a key in vitro measures of damage: the spontaneous and light-evoked activity of RGCs. Treatment with P7C3-S243 immediately after injury and throughout the temporary recovery latent period protects mice from developing chronic visual system dysfunction. Conclusions. Provocative PERG testing serves as a noninvasive test in the living organism to identify early damage to the visual system, which may reflect corresponding damage in the brain that is not otherwise detectable by noninvasive means. This provides the basis for developing an earlier diagnostic test to identify patients at risk for developing chronic CNS and visual system damage after TBI at an earlier stage when treatments may be more effective in preventing these sequelae. In addition, treatment with the neuroprotective agent P7C3-S243 after TBI protects from visual system dysfunction after TBI. PMID:25468886

  9. Validation of copy number variants associated with prostate cancer risk and prognosis.

    PubMed

    Blackburn, August; Wilson, Desiree; Gelfond, Jonathan; Yao, Li; Hernandez, Javier; Thompson, Ian M; Leach, Robin J; Lehman, Donna M

    2014-01-01

    Two recent studies have reported novel heritable copy number variants on chromosomes 2p, 15q, and 12q to be associated with prostate cancer (PCa) risk in non-Hispanic Caucasians. The goal of this study was to determine whether these findings could be independently confirmed in the Caucasian population from the South Texas area. The study subjects consisted of participants of the San Antonio Biomarkers of Risk for PCa cohort and additional cases ascertained in the same metropolitan area. We genotyped all 7 of the reported copy number variants using real-time quantitative polymerase chain reaction in 1,536 (317 cases and 1,219 controls) non-Hispanic Caucasian men, and additionally, we genotyped 632 (191 cases and 441 controls) Hispanic Caucasian men for one of these variants, a deletion on 2p24.3. Association of the deletion on 2p24.3 with overall PCa risk did not meet our significance criteria but was consistent with previous reports (odds ratio, 1.40; 95% confidence interval 0.99-2.00; P = 0.06). Among Hispanic Caucasians, this deletion is much less prevalent (minor allele frequencies of 0.059 and 0.024 in non-Hispanic and Hispanic Caucasians, respectively) and did not show evidence of association with risk for PCa. Interestingly, among non-Hispanic Caucasians, carrying a homozygous deletion of 2p24.3 was significantly associated with high-grade PCa as defined by Gleason score sum ≥8 (odds ratio, 27.99; 95% confidence interval 1.99-392.6; P = 0.007 [the Fisher exact test]). The remaining 6 copy number variable regions either were not polymorphic in our cohort of non-Hispanic Caucasians or showed no evidence of association. Our findings are consistent with the reported observation that a heritable deletion on 2p24.3 is associated with PCa risk in non-Hispanic Caucasians. Additionally, our observations indicate that the 2p24.3 variant is associated with risk for high-grade PCa in a recessive manner. We were unable to replicate any association with PCa for the variants on chromosomes 15q and 12q, which may be explained by regional population differences in low frequency variants and disease heterogeneity. Published by Elsevier Inc.

  10. First images of asteroid 243 Ida

    USGS Publications Warehouse

    Belton, M.J.S.; Chapman, C.R.; Veverka, J.; Klaasen, K.P.; Harch, A.; Greeley, R.; Greenberg, R.; Head, J. W.; McEwen, A.; Morrison, D.; Thomas, P.C.; Davies, M.E.; Carr, M.H.; Neukum, G.; Fanale, F.P.; Davis, D.R.; Anger, C.; Gierasch, P.J.; Ingersoll, A.P.; Pilcher, C.B.

    1994-01-01

    The first images of the asteroid 243 Ida from Galileo show an irregular object measuring 56 kilometers by 24 kilometers by 21 kilometers. Its surface is rich in geologic features, including systems of grooves, blocks, chutes, albedo features, crater chains, and a full range of crater morphologies. The largest blocks may be distributed nonuniformly across the surface; lineaments and dark-floored craters also have preferential locations. Ida is interpreted to have a substantial regolith. The high crater density and size-frequency distribution (-3 differential power-law index) indicate a surface in equilibrium with saturated cratering. A minimum model crater age for Ida - and therefore for the Koronis family to which Ida belongs - is estimated at 1 billion years, older than expected.

  11. A Third Locus for Autosomal Dominant Cerebellar Ataxia Type 1 Maps to Chromosome 14q24.3-qter: Evidence for the Existence of a Fourth Locus

    PubMed Central

    Stevanin, Giovanni; Le Guern, Eric; Ravisé, Nicole; Chneiweiss, Hervé; Dürr, Alexandra; Cancel, Géraldine; Vignal, Alain; Boch, Anne-Laure; Ruberg, Merle; Penet, Christiane; Pothin, Yolaine; Lagroua, Isabelle; Haguenau, Michel; Rancurel, Gérald; Weissenbach, Jean; Agid, Yves; Brice, Alexis

    1994-01-01

    The autosomal dominant cerebellar ataxias (ADCA) type I are a group of neurological disorders that are clinically and genetically heterogeneous. Two genes implicated in the disease, SCA1 (spinal cerebellar ataxia 1) and SCA2, are already localized. We have mapped a third locus to chromosome 14q24.3-qter, by linkage analysis in a non-SCA1/non-SCA2 family and have confirmed its existence in a second such family. We suggest designating this new locus “SCA3.” Combined analysis of the two families restricted the SCA3 locus to a 15-cM interval between markers D14S67 and D14S81. The gene for Machado-Joseph disease (MJD), a clinically different form of ADCA type I, has been recently assigned to chromosome 14q24.3-q32. Although the SCA3 locus is within the MJD region, linkage analyses cannot yet demonstrate whether they result from mutations of the same gene. Linkage to all three loci (SCA1, SCA2, and SCA3) was excluded in another family, which indicates the existence of a fourth ADCA type I locus. PMID:8279460

  12. Description of two new plasmids isolated from Francisella philomiragia strains and construction of shuttle vectors for the study of Francisella tularensis.

    PubMed

    Le Pihive, E; Blaha, D; Chenavas, S; Thibault, F; Vidal, D; Valade, E

    2009-11-01

    Francisella tularensis is the causative agent of tularemia, a zoonotic disease often transmitted to humans by infected animals. The lack of useful specific genetic tools has long hampered the study of F. tularensis subspecies. We identified and characterized two new plasmids, pF242 and pF243, isolated from Francisella philomiragia strains ATCC 25016 and ATCC 25017, respectively. Sequence analysis revealed that pF242 and pF243 are closely related to pC194 and pFNL10 plasmids, respectively. Two generations of pF242- and pF243-based shuttle vectors, harboring several antibiotic resistance markers, were developed. We used the first generation to compare transformation efficiencies in two virulent F. tularensis subspecies. We found that electroporation was more efficient than cryotransformation: almost all vectors tested were successfully introduced by electroporation into Francisella strains with a high level of efficiency. The second generation of shuttle vectors, containing a multiple cloning site and/or gfp gene downstream of Francisella groES promotor, was used for GFP production in F. tularensis. The development of new shuttle vectors offers new perspectives in the genetic manipulation of F. tularensis, helping to elucidate the mechanisms underlying its virulence.

  13. De novo 14q24.2q24.3 microdeletion including IFT43 is associated with intellectual disability, skeletal anomalies, cardiac anomalies, and myopia.

    PubMed

    Stokman, Marijn F; Oud, Machteld M; van Binsbergen, Ellen; Slaats, Gisela G; Nicolaou, Nayia; Renkema, Kirsten Y; Nijman, Isaac J; Roepman, Ronald; Giles, Rachel H; Arts, Heleen H; Knoers, Nine V A M; van Haelst, Mieke M

    2016-06-01

    We report an 11-year-old girl with mild intellectual disability, skeletal anomalies, congenital heart defect, myopia, and facial dysmorphisms including an extra incisor, cup-shaped ears, and a preauricular skin tag. Array comparative genomic hybridization analysis identified a de novo 4.5-Mb microdeletion on chromosome 14q24.2q24.3. The deleted region and phenotype partially overlap with previously reported patients. Here, we provide an overview of the literature on 14q24 microdeletions and further delineate the associated phenotype. We performed exome sequencing to examine other causes for the phenotype and queried genes present in the 14q24.2q24.3 microdeletion that are associated with recessive disease for variants in the non-deleted allele. The deleted region contains 65 protein-coding genes, including the ciliary gene IFT43. Although Sanger and exome sequencing did not identify variants in the second IFT43 allele or in other IFT complex A-protein-encoding genes, immunocytochemistry showed increased accumulation of IFT-B proteins at the ciliary tip in patient-derived fibroblasts compared to control cells, demonstrating defective retrograde ciliary transport. This could suggest a ciliary defect in the pathogenesis of this disorder. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. Copy number variations of obesity relevant loci associated with body mass index in young Chinese.

    PubMed

    Sun, Chen; Cao, Min; Shi, Juan; Li, Lijuan; Miao, Lin; Hong, Jie; Cui, Bin; Ning, Guang

    2013-03-10

    Obesity is one of the most complex human diseases that are widely concerned and studied. More recently, copy number variations (CNVs) emerge as another important genetic marker to influence various human diseases. To elucidate the relationship between obesity and CNVs, this current study selected obesity-related candidate CNVs and analyzed their association with body mass index (BMI). Results showed that a CNV locus, 8q24.3, was significantly different (P=0.0070) in CNV frequency between the obese and healthy controls in a young eastern Chinese cohort, while no statistical significance was observed in other seven candidate loci including well reported 10q11.22 and 16p11.2 loci. The association of 8q24.3 CNVs with BMI of the subjects only showed marginal significance, while the copy number (CN) of 5p15.33 had a significant correlation with the BMI of the subject. These results suggested that 8q24.3 CN gains was associated with obesity, and 5p15.33 might also contribute to obesity pathogenesis, highlighting the importance of these CNVs for obesity risks, as well as providing new evidence for CNVs in the pathology of common diseases. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Neutron capture cross section of ^243Am

    NASA Astrophysics Data System (ADS)

    Jandel, M.

    2009-10-01

    The Detector for Advanced Neutron Capture Experiments (DANCE) at Los Alamos National Laboratory (LANL) was used for neutron capture cross section measurement on ^243Am. The high granularity of DANCE (160 BaF2 detectors in a 4π geometry) enables the efficient detection of prompt gamma-rays following neutron capture. DANCE is located on the 20.26 m neutron flight path 14 (FP14) at the Manuel Lujan Jr. Neutron Scattering Center at the Los Alamos Neutron Science Center (LANSCE). The methods and techniques established in [1] were used for the determination of the ^243Am neutron capture cross section. The cross sections were obtained in the range of neutron energies from 0.02 eV to 400 keV. The resonance region was analyzed using SAMMY7 and resonance parameters were extracted. The results will be compared to existing evaluations and calculations. Work was performed under the auspices of the U.S. Department of Energy at Los Alamos National Laboratory by the Los Alamos National Security, LLC under Contract No. DE-AC52-06NA25396 and at Lawrence Livermore National Laboratory by the Lawrence Livermore National Security, LLC under Contract No. DE-AC52-07NA27344. [4pt] [1] M. Jandel et al., Phys. Rev. C78, 034609 (2008)

  16. A new trivalent SnSAG surface antigen chimera for efficient detection of antibodies against Sarcocystis neurona and diagnosis of equine protozoal myeloencephalitis.

    PubMed

    Yeargan, Michelle; de Assis Rocha, Izabela; Morrow, Jennifer; Graves, Amy; Reed, Stephen M; Howe, Daniel K

    2015-05-01

    Enzyme-linked immunosorbent assays (ELISAs) based on the SnSAG surface antigens of Sarcocystis neurona provide reliable detection of infection by the parasite. Moreover, accurate serodiagnosis of equine protozoal myeloencephalitis (EPM) is achieved with the SnSAG ELISAs by measuring antibodies in serum and cerebrospinal fluid (CSF) to reveal active infection in the central nervous system. Two independent ELISAs based on recombinant (r)SnSAG2 or a chimeric fusion of SnSAG3 and SnSAG4 (rSnSAG4/3) are currently used together for EPM serodiagnosis to overcome varied antibody responses in different horses. To achieve reliable antibody detection with a single ELISA instead of 2 separate ELISAs, rSnSAG2 was fused with rSnSAG4/3 into a single trivalent protein, designated rSnSAG2/4/3. Paired serum and CSF from 163 horses were tested with all 3 ELISAs. When the consensus antibody titers obtained with the rSnSAG2 and rSnSAG4/3 ELISAs were compared to the single SAG2/4/3 ELISA titers, Spearman rank correlation coefficients of ρ = 0.74 and ρ = 0.90 were obtained for serum and CSF, respectively, indicating strong agreement between the tests. When the rSnSAG2 and rSnSAG4/3 consensus serum-to-CSF titer ratio was compared to the rSnSAG2/4/3 serum-to-CSF titer ratio, the Spearman correlation coefficient was ρ = 0.87, again signifying strong agreement. Importantly, comparing the diagnostic interpretation of the serum-to-CSF titer ratios yielded a Cohen kappa value of 0.77. These findings suggest that the single ELISA based on the trivalent rSnSAG2/4/3 will provide serologic and diagnostic results that are highly comparable to the consensus of the 2 independent ELISAs based on rSnSAG2 and rSnSAG4/3. © 2015 The Author(s).

  17. Asteroid Ida and Its Moon

    NASA Image and Video Library

    1996-02-01

    This is the first full picture showing both asteroid 243 Ida and its newly discovered moon to be transmitted to Earth from the National Aeronautics and Space Administration's (NASA's) Galileo spacecraft--the first conclusive evidence that natural satellites of asteroids exist. Ida, the large object, is about 56 kilometers (35 miles) long. Ida's natural satellite is the small object to the right. This portrait was taken by Galileo's charge-coupled device (CCD) camera on August 28, 1993, about 14 minutes before the Jupiter-bound spacecraft's closest approach to the asteroid, from a range of 10,870 kilometers (6,755 miles). Ida is a heavily cratered, irregularly shaped asteroid in the main asteroid belt between Mars and Jupiter -- the 243rd asteroid to be discovered since the first was found at the beginning of the 19th century. Ida is a member of a group of asteroids called the Koronis family. The small satellite, which is about 1.5 kilometers (1 mile) across in this view, has yet to be given a name by astronomers. It has been provisionally designated '1993 (243) 1' by the International Astronomical Union. ('1993' denotes the year the picture was taken, '243' the asteroid number and '1' the fact that it is the first moon of Ida to be found.) Although appearing to be 'next' to Ida, the satellite is actually in the foreground, slightly closer to the spacecraft than Ida is. Combining this image with data from Galileo's near-infrared mapping spectrometer, the science team estimates that the satellite is about 100 kilometers (60 miles) away from the center of Ida. This image, which was taken through a green filter, is one of a six-frame series using different color filters. The spatial resolution in this image is about 100 meters (330 feet) per pixel. http://photojournal.jpl.nasa.gov/catalog/PIA00136

  18. (-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia.

    PubMed

    Voorhees, Jaymie R; Remy, Matthew T; Cintrón-Pérez, Coral J; El Rassi, Eli; Khan, Michael Z; Dutca, Laura M; Yin, Terry C; McDaniel, Latisha N; Williams, Noelle S; Brat, Daniel J; Pieper, Andrew A

    2017-11-06

    In addition to cognitive deficits, Alzheimer's disease (AD) is associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes cognitive deficits in patients with AD. Unfortunately, the field has seen only minimal therapeutic advances, underscoring the critical need for new treatments. P7C3 aminopropyl carbazoles promote neuronal survival by enhancing nicotinamide adenine dinucleotide flux in injured neurons. Neuroprotection with P7C3 compounds has been demonstrated in preclinical models of neurodegeneration by virtue of promoting neuronal survival independently of early disease-specific pathology, resulting in protection from cognitive deficits and depressive-like behavior. We hypothesize that P7C3 compounds might be uniquely applicable to patients with AD, given the comorbid presentation of depression and cognitive deficits. Aging male and female wild-type and TgF344-AD rats, a well-characterized preclinical AD model, were administered (-)-P7C3-S243 daily for 9 and 18 months, beginning at 6 months of age. Behavioral phenotypes related to cognition and depression were assessed at 15 and 24 months, and brain pathology and biochemistry were assessed at 24 months. (-)-P7C3-S243 safely protected aging male and female wild-type and TgF344-AD rats from cognitive deficits and depressive-like behavior. Depressive-like behavior occurred earlier than cognitive deficits in TgF344-AD rats, consistent with AD in many patients. Treatment with (-)-P7C3-S243 blocked neurodegeneration in TgF344-AD rats, without altering amyloid deposition or indicators of neuroinflammation. Neuronal cell death-specific treatment approaches, such as P7C3 compounds, may represent a new treatment approach for patients experiencing the combination of cognitive deficits and depression associated with AD. Published by Elsevier Inc.

  19. Mammograms

    MedlinePlus

    ... gov/widgets/fahc.html" width="243" height="179" title="Find a Health Center Widget" ... M.D., Community Oncology and Prevention Trials Research Group, Division of Cancer Prevention, National Cancer Institute, ...

  20. Interactive system for geomagnetic data analysis

    NASA Astrophysics Data System (ADS)

    Solovev, Igor

    2017-10-01

    The paper suggests the methods for analyzing geomagnetic field variations, which are implemented in "Aurora" software system for complex analysis of geophysical parameters. The software system allows one to perform a detailed magnetic data analysis. The methods allow one to estimate the intensity of geomagnetic perturbations and to allocate increased geomagnetic activity periods. The software system is publicly available (http://aurorasa.ikir.ru:8580, http://www.ikir.ru:8280/lsaserver/MagneticPage.jsp). This research was supported by the Russian Science Foundation (Project No. 14-11-00194).

  1. Neutron-Induced Fission Cross Sections of 240Pu, 243Am, and natW in the Energy Range 1-200 MeV

    NASA Astrophysics Data System (ADS)

    Laptev, A. B.; Donets, A. Yu.; Dushin, V. N.; Fomichev, A. V.; Fomichev, A. A.; Haight, R. C.; Shcherbakov, O. A.; Soloviev, S. M.; Tuboltsev, Yu. V.; Vorobyev, A. S.

    2005-05-01

    A long-range research program devoted to measurements of neutron-induced fission cross-sections of actinides and stable isotopes is under way at the GNEIS facility. By now the new series of experiments for measurements of fission cross-section ratios relative to 235U has been completed for 240Pu, 243Am, and natW in a wide energy range of incident neutrons from 1 MeV to 200 MeV in the frame of the ISTC Project ♯1971. The measurements were performed using the multiplate ionization chamber and time-of-flight techniques. The results obtained in this measurement are presented in comparison with the other data.

  2. 40 CFR 243.101 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... operations on pavements, houses, commercial buildings, and other structures. (j) Curb collection means... demolition wastes; and infectious wastes. (z) Stationary compactor means a powered machine which is designed...

  3. 40 CFR 243.101 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... operations on pavements, houses, commercial buildings, and other structures. (j) Curb collection means... demolition wastes; and infectious wastes. (z) Stationary compactor means a powered machine which is designed...

  4. 40 CFR 243.101 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... operations on pavements, houses, commercial buildings, and other structures. (j) Curb collection means... demolition wastes; and infectious wastes. (z) Stationary compactor means a powered machine which is designed...

  5. 40 CFR 243.101 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... operations on pavements, houses, commercial buildings, and other structures. (j) Curb collection means... demolition wastes; and infectious wastes. (z) Stationary compactor means a powered machine which is designed...

  6. 40 CFR 243.101 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... operations on pavements, houses, commercial buildings, and other structures. (j) Curb collection means... demolition wastes; and infectious wastes. (z) Stationary compactor means a powered machine which is designed...

  7. Oral Health

    MedlinePlus

    ... gov/widgets/fahc.html" width="243" height="179" title="Find a Health Center Widget" ... Atkinson, D.D.S., Chief, Center for Clinical Research, Division of Extramural Research, National Institute of Dental ...

  8. Polycyclic Aromatic Hydrocarbons-Associated MicroRNAs and Heart Rate Variability in Coke Oven Workers.

    PubMed

    Huang, Suli; Deng, Qifei; Feng, Jing; Zhang, Xiaomin; Dai, Xiayun; Li, Lu; Yang, Binyao; Wu, Tangchun; Cheng, Jinquan

    2016-01-01

    We aimed to evaluate the association between polycyclic aromatic hydrocarbons (PAHs)-related microRNAs (miRNAs) and heart rate variability indices in coke oven workers. We recruited 365 male coke oven workers and measured urinary PAH metabolites by gas chromatography-mass spectrometry. Five heart rate variability indices were measured using three-channel Holter monitor. Six miRNAs were detected by TaqMan miRNA assays (Life Technologies, Foster City, CA). miR-24-3p, miR-27a-3p, miR-142-5p, and miR-320b were negatively associated with the root mean of square of successive differences between adjacent normal NN intervals (RMSSD) (P(trend) = 0.006, 0.047, 0.019, 0.011, respectively). miR-142-5p and miR-320b were also negatively associated with standard deviation of all normal to normal NN intervals (SDNN) (P(trend) = 0.01 and 0.035). miR-24-3p, miR-27a-3p, and miR-320b were significantly interacted with multiple PAH metabolites and influenced heart rate variability indices, whereas miR-24-3p also significantly interacted with smoking to influence low frequency (P(interaction) < 0.05 for all). Plasma miRNAs might act as potential biomarkers for the adverse effect of PAH exposure on the cardiovascular system.

  9. Cold-Induced Browning Dynamically Alters the Expression Profiles of Inflammatory Adipokines with Tissue Specificity in Mice.

    PubMed

    Luo, Xiao; Jia, Ru; Zhang, Qiangling; Sun, Bo; Yan, Jianqun

    2016-05-23

    Cold exposure or β₃-adrenoceptor agonist treatment induces the adipose tissues remodeling, relevant for beige adipogenesis within white adipose tissue (WAT). It remains unclear whether this process influences inflammatory adipokines expression in adipose tissues. We determine the temporal profile of cold or β₃-adrenoceptor agonist (CL316,243)-induced changes in the expression of inflammatory adipokines in adipose tissues in mice or primary mice adipocytes. Male C57BL/6J mice at eight weeks old were exposed to 4 °C for 1-5 days. Interscapular brown adipose tissue (iBAT), inguinal subcutaneous WAT (sWAT) and epididymal WAT (eWAT) were harvested for gene and protein expression analysis. In addition, cultured primary mice brown adipocyte (BA) and white adipocyte (WA) treated with or without CL316,243 were harvested for gene expression analysis. The inflammatory adipokines expressed significantly higher in WAT than BAT at baseline. They were rapidly changed in iBAT, while down-regulated in sWAT and up-regulated in eWAT during the cold acclimation. Upon CL316,243 treatment, detected inflammatory adipokines except Leptin were transiently increased in both BA and WA. Our in vivo and in vitro data demonstrate that the browning process alters the inflammatory adipokines expression in adipose tissues, which is acutely responded to in iBAT, dynamically decreased in sWAT whilst increased in eWAT for compensation.

  10. Parkin-mediated mitophagy is downregulated in browning of white adipose tissue.

    PubMed

    Taylor, David; Gottlieb, Roberta A

    2017-04-01

    Browning of white adipose tissue (WAT) promotes increased energy expenditure through the action of uncoupling protein 1 (UCP1) and is an attractive target to promote weight loss in obesity. Lowering of mitochondrial membrane potential by UCP1 is uniquely beneficial in this context; in other tissues, reduced membrane potential promotes mitochondrial clearance via mitophagy. It is unknown how parkin-mediated mitophagy is regulated in beige adipocytes. The relationship between parkin expression and WAT browning was investigated in 3T3-L1 adipocytes and parkin-deficient male C57BL/6 mice in response to pharmacological browning stimuli. Rosiglitazone treatment in 3T3-L1 adipocytes promoted mitochondrial biogenesis, UCP1 expression, and mitochondrial uncoupling. Parkin expression was decreased and reduced mitochondrial-associated parkin, and p62 indicated a reduction in mitophagy activity. Parkin overexpression prevented mitochondrial remodeling in response to rosiglitazone. In CL 316,243-treated wild-type mice, decreased parkin expression was observed in subcutaneous inguinal WAT, where UCP1 was strongly induced. CL 316,243 treatment weakly induced UCP1 expression in the gonadal depot, where parkin expression was unchanged. In contrast, parkin-deficient mice exhibited robust UCP1 expression in gonadal WAT following CL 316,243 treatment. WAT browning was associated with a decrease in parkin-mediated mitophagy, and parkin expression antagonized browning of WAT. © 2017 The Obesity Society.

  11. Pathogenesis of coxsackievirus B2 in mice: characterization of clinical isolates of the coxsackievirus B2 from patients with myocarditis and aseptic meningitis in Korea.

    PubMed

    Hong, Jiyoung; Kang, Bunghak; Yeo, Sanggu; Jee, Youngmee; Park, Jae-Hak

    2017-12-31

    Group B coxsackieviruses (CVBs) are a group of common human pathogens producing various clinical symptoms. Although the virology of CVB is well known, there is limited information on viral pathogenesis and the relationship between clinical symptoms and viral phenotype, particularly for CVB type 2 (CVB2). In 2004 in Korea, two CVB2 strains were isolated: CB2/04/279 from stool of an acute myocarditis patient with heart failure and CB2/04/243 from an aseptic meningitis patient. In this study, a high degree of homology was observed between the CB2/04/279 and CB2/04/243 full genome sequences. The two Korean CVB2 isolates had 93.1% homology compared to 82.1%-82.5% nucleotide sequence identity with the cardiovirulence-associated reference CVB strain Ohio-1 (CVB/O). CVB2-induced pathogenesis was analyzed, focusing on virus-induced pathology of various tissues in 4-week-old BALB/c inbred male mice. Myocarditis developed and extensive pancreatic inflammation was observed in all mice infected with CB2/04/279 or CVB/O, but not in animals infected with CB2/04/243. This is the first report of the full-genomic sequence and pathogenesis of the CVB2 strain isolated from an acute myocarditis patient in Korea.

  12. Taxonomically Different Co-Microsymbionts of a Relict Legume, Oxytropis popoviana, Have Complementary Sets of Symbiotic Genes and Together Increase the Efficiency of Plant Nodulation.

    PubMed

    Safronova, Vera I; Belimov, Andrey A; Sazanova, Anna L; Chirak, Elizaveta R; Verkhozina, Alla V; Kuznetsova, Irina G; Andronov, Evgeny E; Puhalsky, Jan V; Tikhonovich, Igor A

    2018-06-20

    Ten rhizobial strains were isolated from root nodules of a relict legume Oxytropis popoviana Peschkova. For identification of the isolates, sequencing of rrs, the internal transcribed spacer region, and housekeeping genes recA, glnII, and rpoB was used. Nine fast-growing isolates were Mesorhizobium-related; eight strains were identified as M. japonicum and one isolate belonged to M. kowhaii. The only slow-growing isolate was identified as a Bradyrhizobium sp. Two strains, M. japonicum Opo-242 and Bradyrhizobium sp. strain Opo-243, were isolated from the same nodule. Symbiotic genes of these isolates were searched throughout the whole-genome sequences. The common nodABC genes and other symbiotic genes required for plant nodulation and nitrogen fixation were present in the isolate Opo-242. Strain Opo-243 did not contain the principal nod, nif, and fix genes; however, five genes (nodP, nodQ, nifL, nolK, and noeL) affecting the specificity of plant-rhizobia interactions but absent in isolate Opo-242 were detected. Strain Opo-243 could not induce nodules but significantly accelerated the root nodule formation after coinoculation with isolate Opo-242. Thus, we demonstrated that taxonomically different strains of the archaic symbiotic system can be co-microsymbionts infecting the same nodule and promoting the nodulation process due to complementary sets of symbiotic genes.

  13. 75 FR 33269 - Procurement List; Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... Procurement List: Product Wooden Trunk Locker NSN: 8460-00-243-3234. NPA: Employment Source, Inc... competitor enjoying a profitable subcontract forever if the commercial portion of the trunk locker...

  14. 10 CFR 600.243 - Enforcement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of the funding period in which the termination takes effect. (d) Relationship to debarment and... applicable to the action involved. (c) Effects of suspension and termination. Costs of grantee or subgrantee...

  15. 10 CFR 600.243 - Enforcement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of the funding period in which the termination takes effect. (d) Relationship to debarment and... applicable to the action involved. (c) Effects of suspension and termination. Costs of grantee or subgrantee...

  16. 47 CFR 24.243 - The cost-sharing formula.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC filing costs; site acquisition and civil works; zoning costs; training; disposal of old equipment; test...

  17. Retinol values in the plasma of the Arabian camel (Camelus dromedarius) and the influence of aflatoxicosis.

    PubMed

    Abbas, T A; Ali, B H

    2001-08-01

    The normal values are reported of the concentration of vitamin A (retinol) in the plasma of 44 male and female adult camels (Camelus dromedarius) in the United Arab Emirates. The concentrations of the vitamin in the plasma of eight camels of both sexes afflicted with aflatoxicosis were also determined. The mean concentration (+/-SD) of the vitamin in healthy camels was 460.1 +/- 49.3 ng/L. Sex had no significant effect on the concentration of the vitamin. Camels with aflatoxicosis had a mean concentration of retinol in the plasma of 243.4 +/- 32.3 ng/L. The concentrations of aflatoxins in the liver and ruminal contents of these animals were 18.2 +/- 1.3 and 243.4 microg/kg, respectively.

  18. The equilibrium constant for N2O5 = NO2 + NO3 - Absolute determination by direct measurement from 243 to 397 K

    NASA Technical Reports Server (NTRS)

    Cantrell, C. A.; Davidson, J. A.; Mcdaniel, A. H.; Shetter, R. E.; Calvert, J. G.

    1988-01-01

    Direct determinations of the equilibrium constant for the reaction N2O5 = NO2 + NO3 were carried out by measuring NO2, NO3, and N2O5 using long-path visible and infrared absorption spectroscopy as a function of temperature from 243 to 397 K. The first-order decay rate constant of N2O5 was experimentally measured as a function of temperature. These results are in turn used to derive a value for the rate coefficient for the NO-forming channel in the reaction of NO3 with NO2. The implications of the results for atmospheric chemistry, the thermodynamics of NO3, and for laboratory kinetics studies are discussed.

  19. 7 CFR 58.243 - Checking quality.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Periodically samples of product and environmental material shall be tested for salmonella. Test results shall be negative when samples are tested for salmonella. Line samples should be taken periodically as an...

  20. 7 CFR 58.243 - Checking quality.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Periodically samples of product and environmental material shall be tested for salmonella. Test results shall be negative when samples are tested for salmonella. Line samples should be taken periodically as an...

  1. 7 CFR 58.243 - Checking quality.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Periodically samples of product and environmental material shall be tested for salmonella. Test results shall be negative when samples are tested for salmonella. Line samples should be taken periodically as an...

  2. 7 CFR 58.243 - Checking quality.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Periodically samples of product and environmental material shall be tested for salmonella. Test results shall be negative when samples are tested for salmonella. Line samples should be taken periodically as an...

  3. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment and finishing of wine. Agar-agar, carrageenan, cellulose, and diatomaceous earth are commonly employed inert...

  4. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment and finishing of wine. Agar-agar, carrageenan, cellulose, and diatomaceous earth are commonly employed inert...

  5. 17 CFR 243.101 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... adviser) learns that there has been a non-intentional disclosure by the issuer or person acting on behalf... information through another method (or combination of methods) of disclosure that is reasonably designed to...

  6. 40 CFR 180.243 - Propazine; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances... the herbicide propazine (2-chloro-4,6-bis(isopropylamino)-s-triazine in or on the following raw...

  7. Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.

    PubMed

    Daniil, Georgios; Zannis, Vassilis I; Chroni, Angeliki

    2013-01-01

    ATP binding cassette transporter G1 (ABCG1) mediates the cholesterol transport from cells to high-density lipoprotein (HDL), but the role of apolipoprotein A-I (apoA-I), the main protein constituent of HDL, in this process is not clear. To address this, we measured cholesterol efflux from HEK293 cells or J774 mouse macrophages overexpressing ABCG1 using as acceptors reconstituted HDL (rHDL) containing wild-type or various mutant apoA-I forms. It was found that ABCG1-mediated cholesterol efflux was severely reduced (by 89%) when using rHDL containing the carboxyl-terminal deletion mutant apoA-I[Δ(185-243)]. ABCG1-mediated cholesterol efflux was not affected or moderately decreased by rHDL containing amino-terminal deletion mutants and several mid-region deletion or point apoA-I mutants, and was restored to 69-99% of control by double deletion mutants apoA-I[Δ(1-41)Δ(185-243)] and apoA-I[Δ(1-59)Δ(185-243)]. These findings suggest that the central helices alone of apoA-I associated to rHDL can promote ABCG1-mediated cholesterol efflux. Further analysis showed that rHDL containing the carboxyl-terminal deletion mutant apoA-I[Δ(185-243)] only slightly reduced (by 22%) the ABCG1-mediated efflux of 7-ketocholesterol, indicating that depending on the sterol type, structural changes in rHDL-associated apoA-I affect differently the ABCG1-mediated efflux of cholesterol and 7-ketocholesterol. Overall, our findings demonstrate that rHDL-associated apoA-I structural changes affect the capacity of rHDL to accept cellular cholesterol by an ABCG1-mediated process. The structure-function relationship seen here between rHDL-associated apoA-I mutants and ABCG1-mediated cholesterol efflux closely resembles that seen before in lipid-free apoA-I mutants and ABCA1-dependent cholesterol efflux, suggesting that both processes depend on the same structural determinants of apoA-I.

  8. 29 CFR 1952.243 - Final approval determination.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Lisburne Long Range Missile Base, Point Lay Short Range Missile Base, Eareckson Air Station on Shemya Island, Fort Greeley Missile Defense in Delta Junction, the U.S. Coast Guard Integrated Support Commands...

  9. 29 CFR 1952.243 - Final approval determination.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Lisburne Long Range Missile Base, Point Lay Short Range Missile Base, Eareckson Air Station on Shemya Island, Fort Greeley Missile Defense in Delta Junction, the U.S. Coast Guard Integrated Support Commands...

  10. 29 CFR 1952.243 - Final approval determination.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Lisburne Long Range Missile Base, Point Lay Short Range Missile Base, Eareckson Air Station on Shemya Island, Fort Greeley Missile Defense in Delta Junction, the U.S. Coast Guard Integrated Support Commands...

  11. 29 CFR 1952.243 - Final approval determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Lisburne Long Range Missile Base, Point Lay Short Range Missile Base, Eareckson Air Station on Shemya Island, Fort Greeley Missile Defense in Delta Junction, the U.S. Coast Guard Integrated Support Commands...

  12. 29 CFR 1952.243 - Final approval determination.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Lisburne Long Range Missile Base, Point Lay Short Range Missile Base, Eareckson Air Station on Shemya Island, Fort Greeley Missile Defense in Delta Junction, the U.S. Coast Guard Integrated Support Commands...

  13. Earmark Elimination Act of 2011

    THOMAS, 112th Congress

    Sen. Toomey, Pat [R-PA

    2011-11-30

    Senate - 12/01/2011 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 243. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... construction and of coarse animal hair or man-made filaments; (C) Any combination of findings and trimmings of... incurred in the growth, production, manufacture, or other processing of the components, findings and...

  15. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... construction and of coarse animal hair or man-made filaments; (C) Any combination of findings and trimmings of... incurred in the growth, production, manufacture, or other processing of the components, findings and...

  16. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... construction and of coarse animal hair or man-made filaments; (C) Any combination of findings and trimmings of... incurred in the growth, production, manufacture, or other processing of the components, findings and...

  17. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... construction and of coarse animal hair or man-made filaments; (C) Any combination of findings and trimmings of... incurred in the growth, production, manufacture, or other processing of the components, findings and...

  18. 19 CFR 10.243 - Articles eligible for preferential treatment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... construction and of coarse animal hair or man-made filaments; (C) Any combination of findings and trimmings of... incurred in the growth, production, manufacture, or other processing of the components, findings and...

  19. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) The floors in the eviscerating room shall be kept clean and reasonably dry during eviscerating... handling equipment shall wear clean garments and should wear caps or hair nets, and shall keep their hands...

  20. 40 CFR 1051.243 - How do I determine deterioration factors from exhaust durability testing?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM RECREATIONAL ENGINES AND..., select vehicles, engines, subsystems, or components for testing. Determine deterioration factors based on...

  1. 40 CFR 243.200-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for the purpose of recycling) shall be stored in such a manner that they do not constitute a fire... recycling) must meet the standards established by the American National Standards Institute (ANSI) for waste...

  2. 40 CFR 243.200-1 - Requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for the purpose of recycling) shall be stored in such a manner that they do not constitute a fire... recycling) must meet the standards established by the American National Standards Institute (ANSI) for waste...

  3. 40 CFR 243.200-1 - Requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for the purpose of recycling) shall be stored in such a manner that they do not constitute a fire... recycling) must meet the standards established by the American National Standards Institute (ANSI) for waste...

  4. 40 CFR 243.200-1 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for the purpose of recycling) shall be stored in such a manner that they do not constitute a fire... recycling) must meet the standards established by the American National Standards Institute (ANSI) for waste...

  5. 40 CFR 243.200-1 - Requirement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for the purpose of recycling) shall be stored in such a manner that they do not constitute a fire... recycling) must meet the standards established by the American National Standards Institute (ANSI) for waste...

  6. 40 CFR 243.200-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waste containers should be constructed of corrosion resistant metal or other material which will not.... Containers should have covers which are tight-fitting to resist the intrusion of water and vectors, and...

  7. 40 CFR 243.100 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Disposal Act, as amended (Pub. L. 89-272). (b) The guidelines apply to the collection of residential... available. It is left to the head of the responsible agency to decide how the requirements of the guidelines...

  8. Analysis of decay chains of superheavy nuclei produced in the 249Bk+48Ca and 243Am+48Ca reactions

    NASA Astrophysics Data System (ADS)

    Zlokazov, V. B.; Utyonkov, V. K.

    2017-07-01

    The analysis of decay chains starting at superheavy nuclei 293Ts and 289Mc is presented. The spectroscopic properties of nuclei identified during the experiments using the 249Bk+48Ca and 243Am+48Ca reactions studied at the gas-filled separators DGFRS, TASCA and BGS are considered. We present the analysis of decay data using widely adopted statistical methods and applying them to the short decay chains of parent odd-Z nuclei. We find out that the recently suggested method of analyzing decay chains by Forsberg et al may lead to questionable conclusions when applied for the analysis of radioactive decays. Our discussion demonstrates reasonable congruence of α-particle energies and decay times of nuclei assigned to isotopes 289Mc, 285Nh and 281Rg observed in both reactions.

  9. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome

    PubMed Central

    Willemsen, Marjolein H; Fernandez, Bridget A; Bacino, Carlos A; Gerkes, Erica; de Brouwer, Arjan PM; Pfundt, Rolph; Sikkema-Raddatz, Birgit; Scherer, Stephen W; Marshall, Christian R; Potocki, Lorraine; van Bokhoven, Hans; Kleefstra, Tjitske

    2010-01-01

    The clinical use of array comparative genomic hybridization in the evaluation of patients with multiple congenital anomalies and/or mental retardation has recently led to the discovery of a number of novel microdeletion and microduplication syndromes. We present four male patients with overlapping molecularly defined de novo microdeletions of 16q24.3. The clinical features observed in these patients include facial dysmorphisms comprising prominent forehead, large ears, smooth philtrum, pointed chin and wide mouth, variable cognitive impairment, autism spectrum disorder, structural anomalies of the brain, seizures and neonatal thrombocytopenia. Although deletions vary in size, the common region of overlap is only 90 kb and comprises two known genes, Ankyrin Repeat Domain 11 (ANKRD11) (MIM 611192) and Zinc Finger 778 (ZNF778), and is located approximately 10 kb distally to Cadherin 15 (CDH15) (MIM 114019). This region is not found as a copy number variation in controls. We propose that these patients represent a novel and distinctive microdeletion syndrome, characterized by autism spectrum disorder, variable cognitive impairment, facial dysmorphisms and brain abnormalities. We suggest that haploinsufficiency of ANKRD11 and/or ZNF778 contribute to this phenotype and speculate that further investigation of non-deletion patients who have features suggestive of this 16q24.3 microdeletion syndrome might uncover other mutations in one or both of these genes. PMID:19920853

  10. 3 Tesla breast MR imaging as a problem-solving tool: Diagnostic performance and incidental lesions

    PubMed Central

    Spick, Claudio; Szolar, Dieter H. M.; Preidler, Klaus W.; Reittner, Pia; Rauch, Katharina; Brader, Peter; Tillich, Manfred

    2018-01-01

    Purpose To investigate the diagnostic performance and incidental lesion yield of 3T breast MRI if used as a problem-solving tool. Methods This retrospective, IRB-approved, cross-sectional, single-center study comprised 302 consecutive women (mean: 50±12 years; range: 20–79 years) who were undergoing 3T breast MRI between 03/2013-12/2014 for further workup of conventional and clinical breast findings. Images were read by experienced, board-certified radiologists. The reference standard was histopathology or follow-up ≥ two years. Sensitivity, specificity, PPV, and NPV were calculated. Results were stratified by conventional and clinical breast findings. Results The reference standard revealed 53 true-positive, 243 true-negative, 20 false-positive, and two false-negative breast MRI findings, resulting in a sensitivity, specificity, PPV, and NPV of 96.4% (53/55), 92.4% (243/263), 72.6% (53/73), and 99.2% (243/245), respectively. In 5.3% (16/302) of all patients, incidental MRI lesions classified BI-RADS 3–5 were detected, 37.5% (6/16) of which were malignant. Breast composition and the imaging findings that had led to referral had no significant influence on the diagnostic performance of breast MR imaging (p>0.05). Conclusion 3T breast MRI yields excellent diagnostic results if used as a problem-solving tool independent of referral reasons. The number of suspicious incidental lesions detected by MRI is low, but is associated with a substantial malignancy rate. PMID:29293582

  11. The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses.

    PubMed

    Szentirmai, Éva; Kapás, Levente

    2017-04-19

    Brown adipose tissue (BAT) is regulated by the sympathetic nervous system via β3-adrenergic receptors (β3-AR). Here we tested the hypothesis that pharmacological stimulation of β3-ARs leads to increased sleep in mice and if this change is BAT dependent. In wild-type (WT) animals, administration of CL-316,243, a selective β3-AR agonist, induced significant increases in non-rapid-eye movement sleep (NREMS) lasting for 4-10 h. Simultaneously, electroencephalographic slow-wave activity (SWA) was significantly decreased and body temperature was increased with a delay of 5-6 h. In uncoupling protein 1 (UCP-1) knockout mice, the middle and highest doses of the β3-AR agonist increased sleep and suppressed SWA, however, these effects were significantly attenuated and shorter-lasting as compared to WT animals. To determine if somnogenic signals arising from BAT in response to β3-AR stimulation are mediated by the sensory afferents of BAT, we tested the effects of CL-316,243 in mice with the chemical deafferentation of the intra-scapular BAT pads. Sleep responses to CL-316,243 were attenuated by ~50% in intra-BAT capsaicin-treated mice. Present findings indicate that the activation of BAT via β3-AR leads to increased sleep in mice and that this effect is dependent on the presence of UCP-1 protein and sleep responses require the intact sensory innervation of BAT.

  12. Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase.

    PubMed

    Isaksen, Geir Villy; Hopmann, Kathrin Helen; Åqvist, Johan; Brandsdal, Bjørn Olav

    2016-04-12

    Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine ribonucleosides and 2'-deoxyribonucleosides, yielding the purine base and (2'-deoxy)ribose 1-phosphate as products. While this enzyme has been extensively studied, several questions with respect to the catalytic mechanism have remained largely unanswered. The role of the phosphate and key amino acid residues in the catalytic reaction as well as the purine ring protonation state is elucidated using density functional theory calculations and extensive empirical valence bond (EVB) simulations. Free energy surfaces for adenosine, inosine, and guanosine are fitted to ab initio data and yield quantitative agreement with experimental data when the surfaces are used to model the corresponding enzymatic reactions. The cognate substrates 6-aminopurines (inosine and guanosine) interact with PNP through extensive hydrogen bonding, but the substrate specificity is found to be a direct result of the electrostatic preorganization energy along the reaction coordinate. Asn243 has previously been identified as a key residue providing substrate specificity. Mutation of Asn243 to Asp has dramatic effects on the substrate specificity, making 6-amino- and 6-oxopurines equally good as substrates. The principal effect of this particular mutation is the change in the electrostatic preorganization energy between the native enzyme and the Asn243Asp mutant, clearly favoring adenosine over inosine and guanosine. Thus, the EVB simulations show that this particular mutation affects the electrostatic preorganization of the active site, which in turn can explain the substrate specificity.

  13. Two novel translocation breakpoints upstream of SOX9 define borders of the proximal and distal breakpoint cluster region in campomelic dysplasia.

    PubMed

    Leipoldt, M; Erdel, M; Bien-Willner, G A; Smyk, M; Theurl, M; Yatsenko, S A; Lupski, J R; Lane, A H; Shanske, A L; Stankiewicz, P; Scherer, G

    2007-01-01

    The semilethal skeletal malformation syndrome campomelic dysplasia (CD) with or without XY sex reversal is caused by mutations within the SOX9 gene on 17q24.3 or by chromosomal aberrations (translocations, inversions or deletions) with breakpoints outside the SOX9 coding region. The previously published CD translocation breakpoints upstream of SOX9 fall into two clusters: a proximal cluster with breakpoints between 50-300 kb and a distal cluster with breakpoints between 899-932 kb. Here, we present clinical, cytogenetic and molecular data from two novel CD translocation cases. Case 1 with karyotype 46,XY,t(1;17)(q42.1;q24.3) has characteristic symptoms of CD, including mild tibial bowing, cryptorchidism and hypospadias. By standard fluorescence in situ hybridization (FISH) and by high-resolution fiber FISH, the 17q breakpoint was mapped 375 kb from SOX9, defining the centromeric border of the proximal breakpoint cluster region. Case 2 with karyotype 46,X,t(Y;17)(q11.2;q24.3) has the acampomelic form of CD and complete XY sex reversal. By FISH and somatic cell hybrid analysis, the 17q breakpoint was mapped 789 kb from SOX9, defining the telomeric border of the distal breakpoint cluster region. We discuss the structure of the 1 Mb cis-control region upstream of SOX9 and the correlation between the position of the 14 mapped translocation breakpoints with respect to disease severity and XY sex reversal.

  14. ARC-1999-AC99-0013-4

    NASA Image and Video Library

    1999-01-26

    Prince Willem-Alexander van Oranje (Crown Prince of the Netherlands) visits Ames. Shown here with Dr Henry McDonald, Ames Director in lobby of N-243. His visit was prompted by his strong personal interest in aviation.

  15. Alternative Fuels Data Center

    Science.gov Websites

    per gasoline gallon equivalent (GGE). The liquefied natural gas (LNG) tax rate is $0.243 per diesel gallon equivalent (DGE). For taxation purposes, one GGE is equal to 5.75 pounds (lbs.) of propane and

  16. Horse Ridge Research Natural Area: guidebook supplement 37.

    Treesearch

    Reid Schuller; Ron. Halvorson

    2008-01-01

    This guidebook describes Horse Ridge Research Natural Area, a 243-ha (600-ac) tract established to represent an example of the western juniper/big sagebrush/threadleaf sedge (Juniperus occidentalis/Artemisia tridentata/Carex filifolia) plant association.

  17. 2011 Combat Vehicles Conference

    DTIC Science & Technology

    2011-10-26

    City ______________________________ State ___________ Zip...Suite, PO Box, Mail Stop, Building, etc.) ___________________________________________________________ City ______________________________ State...LFT&E PVT IOT &E MSIII MSIII (MC - B) Full Rate Production (Qty. 2,084 funded; Qty. 243 unfunded) Development MSII -LRIP (Qty. 17) Extended LRIP

  18. 40 CFR 243.202-2 - Recommended procedures: Design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... collection vehicles: (1) Exterior rear-view mirrors. (2) Back-up lights. (3) Four-way emergency flashers. (4... conserve fuel and minimize pollution should be used in collection vehicles to reduce fuel consumption and air pollution. ...

  19. 40 CFR 98.247 - Records that must be retained.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....246(b), and records of any annual average HHV calculations. (b) If you comply with the mass balance... produced, if you comply with the alternative methodology in § 98.243(c)(4) for determining carbon content...

  20. 25 CFR 243.5 - Who can own imported reindeer, and what limitations apply?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Federal animal health laws and regulations. (b) Imported reindeer must not be intermingled with, or be bred to, Alaskan reindeer without our written consent. Any offspring resulting from a mating with...

  1. 12 CFR 243.8 - No limiting effect or private right of action; confidentiality of resolution plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... systems; (6) A description of foreign operations; (7) The identities of material supervisory authorities; (8) The identities of the principal officers; (9) A description of the corporate governance structure...

  2. 12 CFR 243.8 - No limiting effect or private right of action; confidentiality of resolution plans.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... systems; (6) A description of foreign operations; (7) The identities of material supervisory authorities; (8) The identities of the principal officers; (9) A description of the corporate governance structure...

  3. 12 CFR 243.8 - No limiting effect or private right of action; confidentiality of resolution plans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... systems; (6) A description of foreign operations; (7) The identities of material supervisory authorities; (8) The identities of the principal officers; (9) A description of the corporate governance structure...

  4. 243 E. Ontario Street - Water, Lindsay Light Radiological Survey

    EPA Pesticide Factsheets

    The field gamma measurements within the excavation during the excavation process did not exceed theinstrument threshold previously stated, and ranged from a minimum of 1,400 cpm to a maximum of 2,600cpm shielded.

  5. 243 E. Ontario Street - Sewer, Lindsay Light Radiological Survey

    EPA Pesticide Factsheets

    The field gamma measurements within the excavation during the excavation process did not exceed theinstrument threshold previously stated, and ranged from a minimum of 1,100 cpm to a maximum of 3,600cpm shielded.

  6. 7 CFR 2.43 - Administrator, Foreign Agricultural Service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Investment Act of 2002 (7 U.S.C. 1736o-1). (45) Support remote sensing activities of the Department and... administrative management of the USDA Remote Sensing Archive and the transfer of satellite imagery to all USDA...

  7. 77 FR 19315 - Renewal of Agency Information Collection for Reindeer in Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... 1076-0047, which expires March 30, 2012. DATES: Interested persons are invited to submit comments on or... OMB Control Number: 1076-0047. Title: Reindeer in Alaska, 25 CFR part 243. Brief Description of...

  8. Airborne East Coast/Midwest urban survey at 121.5/243 MHz. [radio frequency interference measurement

    NASA Technical Reports Server (NTRS)

    Taylor, R. E.; Hill, J. S.

    1979-01-01

    Results of an airborne RF interference measurement survey of the emergency-distress, Search and Rescue frequency bands at 121.5 and 243 MHz at an altitude of 25,000 ft over the U.S. East Coast and Midwest urban areas are presented. Included are a series of minutely median profile plots of antenna-noise temperature computed from RF interference power measurements at the output terminal of a quarter-wavelength monopole antenna, for both daytime and nighttime observations. The greatest value, 450,000 K, of minutely median temperature was recorded over New York City at 121.5 MHz during the day. East Coast urban areas exhibited a day-night effect at 121.5 MHz, where nighttime observations had a median value of 8.6-dB below daytime values; Midwest counterparts did not exhibit a significant day-night effect at 121.5 MHz.

  9. Computer aided planning of orthopaedic surgeries: the definition of generic planning steps for bone removal procedures.

    PubMed

    Putzer, David; Moctezuma, Jose Luis; Nogler, Michael

    2017-11-01

    An increasing number of orthopaedic surgeons are using computer aided planning tools for bone removal applications. The aim of the study was to consolidate a set of generic functions to be used for a 3D computer assisted planning or simulation. A limited subset of 30 surgical procedures was analyzed and verified in 243 surgical procedures of a surgical atlas. Fourteen generic functions to be used in 3D computer assisted planning and simulations were extracted. Our results showed that the average procedure comprises 14 ± 10 (SD) steps with ten different generic planning steps and four generic bone removal steps. In conclusion, the study shows that with a limited number of 14 planning functions it is possible to perform 243 surgical procedures out of Campbell's Operative Orthopedics atlas. The results may be used as a basis for versatile generic intraoperative planning software.

  10. Development of spiral-groove self-acting face seals

    NASA Technical Reports Server (NTRS)

    Obrien, M.

    1977-01-01

    An experimental evaluation and a 100-hour endurance test were performed on a spiral groove geometry, self-acting face seal. The seal was tested and operated successfully at maximum conditions of 243.8 m/s surface speed, 199.9 N/sq cm air pressure, and 645.4K (702 F) air temperature. The maximum speed condition of 243.8 m/s was obtained at a shaft speed of 72,500 rpm. Seal wear, gas leakage, and sealing element temperature were monitored during the test. Condition of the seal at the completion of the test was documented and found acceptable for further use. The spiral groove wear rate measured during the endurance test indicates a minimum potential seal life of over 2700 hours. Seal air leakage measured during the test program is within the range considered acceptable for consideration for use in a small gas turbine engine.

  11. 40 CFR 158.243 - Experimental use permit data requirements for terrestrial and aquatic nontarget organisms.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Use Permit Terrestrial and Aquatic Nontarget Organism Data Requirements Guideline No. Data Requirement... Avian dietary toxicity R R R R NR NR TGAI 1, 4 Aquatic Organisms Testing 850.1075 Freshwater fish...

  12. 40 CFR 158.243 - Experimental use permit data requirements for terrestrial and aquatic nontarget organisms.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Use Permit Terrestrial and Aquatic Nontarget Organism Data Requirements Guideline No. Data Requirement... Avian dietary toxicity R R R R NR NR TGAI 1, 4 Aquatic Organisms Testing 850.1075 Freshwater fish...

  13. 40 CFR 158.243 - Experimental use permit data requirements for terrestrial and aquatic nontarget organisms.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Use Permit Terrestrial and Aquatic Nontarget Organism Data Requirements Guideline No. Data Requirement... Avian dietary toxicity R R R R NR NR TGAI 1, 4 Aquatic Organisms Testing 850.1075 Freshwater fish...

  14. 40 CFR 158.243 - Experimental use permit data requirements for terrestrial and aquatic nontarget organisms.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Use Permit Terrestrial and Aquatic Nontarget Organism Data Requirements Guideline No. Data Requirement... Avian dietary toxicity R R R R NR NR TGAI 1, 4 Aquatic Organisms Testing 850.1075 Freshwater fish...

  15. 76 FR 40617 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, Near Hackberry, LA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ...) vertical lift bridge across the Gulf Intracoastal Waterway, mile 243.8 west of Harvey Lock, near Hackberry... work from the operating schedule for the vertical lift bridge on the SR 27 (Ellender Ferry) across the...

  16. Mercado/Robb/Buchdahl coefficients: an update of 243 common glasses

    NASA Astrophysics Data System (ADS)

    Bolser, Michael

    2002-12-01

    The 1983 Mercado/Robb listing of Buchdahl chromatic coordinate coefficients is supplemented with glasses from the Schott and O'Hara catalogues. The coefficients were calculated by using Buchdahl's cubic model. Appropriately selected materials yield a superachromat.

  17. 47 CFR 24.243 - The cost-sharing formula.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC... control; power plant upgrade (if required); electrical grounding systems; Heating Ventilation and Air Conditioning (HVAC) (if required); alternate transport equipment; and leased facilities. C also includes...

  18. 47 CFR 24.243 - The cost-sharing formula.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC... control; power plant upgrade (if required); electrical grounding systems; Heating Ventilation and Air Conditioning (HVAC) (if required); alternate transport equipment; and leased facilities. C also includes...

  19. 47 CFR 24.243 - The cost-sharing formula.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC... control; power plant upgrade (if required); electrical grounding systems; Heating Ventilation and Air Conditioning (HVAC) (if required); alternate transport equipment; and leased facilities. C also includes...

  20. 47 CFR 24.243 - The cost-sharing formula.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; monitoring or control equipment; engineering costs (design/path survey); installation; systems testing; FCC... control; power plant upgrade (if required); electrical grounding systems; Heating Ventilation and Air Conditioning (HVAC) (if required); alternate transport equipment; and leased facilities. C also includes...

  1. 76 FR 78741 - Medicare, Medicaid, Children's Health Insurance Programs; Transparency Reports and Reporting of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... Vol. 76 Monday, No. 243 December 19, 2011 Part II Department of Health and Human Services Centers for Medicare & Medicaid Services 42 CFR Parts 402 and 403 Medicare, Medicaid, Children's Health...; [[Page 78742

  2. 40 CFR 158.240 - Experimental use permit data requirements for ecological effects.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and aquatic nontarget organisms as described in § 158.243 must be submitted to support a request for an experimental use permit. No data for nontarget plant protection must be submitted to support a...

  3. 40 CFR 158.240 - Experimental use permit data requirements for ecological effects.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and aquatic nontarget organisms as described in § 158.243 must be submitted to support a request for an experimental use permit. No data for nontarget plant protection must be submitted to support a...

  4. IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the β-catenin pathway.

    PubMed

    Lombardo, Giusy; Gili, Maddalena; Grange, Cristina; Cavallari, Claudia; Dentelli, Patrizia; Togliatto, Gabriele; Taverna, Daniela; Camussi, Giovanni; Brizzi, Maria Felice

    2018-03-01

    The proangiogenic cytokine Interleukin-3 (IL-3) is released by inflammatory cells in breast and ovarian cancer tissue microenvironments and also acts as an autocrine factor for human breast and kidney tumor-derived endothelial cells (TECs). We have previously shown that IL-3-treated endothelial cells (ECs) release extracellular vesicles (EVs), which serve as a paracrine mechanism for neighboring ECs, by transferring active molecules. The impact of an anti-IL-3R-alpha blocking antibody on the proangiogenic effect of EVs released from TECs (anti-IL-3R-EVs) has therefore been investigated in this study. We have found that anti-IL-3R-EV treatment prevented neovessel formation and, more importantly, also induced the regression of in vivo TEC-derived neovessels. Two miRs that target the canonical wingless (Wnt)/β-catenin pathway, at different levels, were found to be differentially regulated when comparing the miR-cargo of naive TEC-derived EVs (EVs) and anti-IL-3R-EVs. miR-214-3p, which directly targets β-catenin, was found to be upregulated, whereas miR-24-3p, which targets adenomatous polyposis coli (APC) and glycogen synthase kinase-3β (GSK3β), was found to be downregulated. In fact, upon their transfer into the cell, low β-catenin content and high levels of the two members of the "β-catenin destruction complex" were detected. Moreover, c-myc downregulation was found in TECs treated with anti-IL-3R-EVs, pre-miR-214-3p-EVs and antago-miR-24-3p-EVs, which is consistent with network analyses of miR-214-3p and miR-24-3p gene targeting. Finally, in vivo studies have demonstrated the impaired growth of vessels in pre-miR-214-3p-EV- and antago-miR-24-3p-EV-treated animals. These effects became much more evident when combo treatment was applied. The results of the present study identify the canonical Wnt/β-catenin pathway as a relevant mechanism of TEC-derived EV proangiogenic action. Furthermore, we herein provide evidence that IL-3R blockade may yield some significant advantages, than miR targeting, in inhibiting the proangiogenic effects of naive TEC-derived EVs by changing TEC-EV-miR cargo.

  5. Loss of DMRT1 gene in a Mos 45,XY,-9[8]/46,XY,r(9)[29]/47,XY,+idic r(9)× 2[1]/46,XY,idic r(9)[1]/46,XY[1] female presenting with short stature.

    PubMed

    Marsudi, Bagas A; Kartapradja, Hannie; Paramayuda, Chrysantine; Batubara, Jose R L; Harahap, Alida R; Marzuki, Nanis S

    2018-01-01

    A 46,XY sex reversal syndrome is characterized by discordant genetic and phenotypic sex, leading to normal external female genitalia, undeveloped gonads and presence of Müllerian structures in an otherwise 46,XY individual. Chromosome 9pter aberrations, such as ring chromosome have been reported to cause 46,XY disorders of sex development (DSD), due to involvement of DMRT1 gene located at the 9p24.3 region. This study presents a unique case of a 12-year-old female with mos 46,XY, (r)9[31]/45,XY,-9[9] karyotype, presenting with intellectual disability and short stature, mimicking Turner syndrome. Re-karyotyping was performed using standard GTL-banding technique. Further cytogenetic study using standard metaphase fluorescent in situ hybridization (FISH) technique was applied to cultured lymphocytes from peripheral blood, hybridized using green control probe specific to 9q21 loci, and red DMRT1 probe specific to 9p24.3 loci. Cytogenetics and FISH analysis revealed mos 45,XY,-9[8]/46,XY,r(9)[29]/47,XY,+idic r(9)× 2[1]/46,XY,idic r(9)[1]/46,XY[1] and haploinsufficiency of DMRT1 gene in most cells. CGH array revealed a deletion around 1.25 Mb at 9p24.3 loci [arr 9p24.3(204,193-1,457,665)× 1] and three duplications around 13 Mb [9p24.3p22.3(1,477,660-14,506,754)× 3] near the breakage point that formed the ring chromosome 9. The clinical presentation of the subject that mimics Turner syndrome highlights the importance of cytogenetic analysis to detect the possibility of ring chromosome 9. Sex reversal due to haploinsufficiency of DMRT1 gene in ring chromosome 9 structures is exceedingly rare with only a handful of cases ever reported. This finding further highlights the importance of DMRT1 gene in sex determination and differentiation in males. More research is required to pinpoint the exact mechanism that underlies sex reversal caused by DMRT1 haploinsufficiency.

  6. An integrated evaluation of the persistence and effects of 4-nonylphenol in an experimental littoral ecosystem

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liber, K.; Knuth, M.L.; Stay, F.S.

    1999-03-01

    A comprehensive littoral enclosure study was conducted to assess the persistence and distribution of 4-nonylphenol (NP) in a littoral ecosystem, and to evaluate the compound`s effects on resident aquatic biota. Enclosures with a mean ({+-} SD) surface area and volume of 31.4 {+-} 3.3 m{sup 2} and 32.0 {+-} 6.4 m{sup 3}, respectively, received eleven applications at 48-h intervals with one of four different rates of NP. This created a 20-d application period which was followed by a three to fourteen month observation period, depending on the endpoint measured. Mean {+-} SD NP concentrations in the water column measured 2more » h after each application averaged 5 {+-} 4, 23 {+-} 11, 76 {+-} 21, and 243 {+-} 41 {micro}g/L at nominal treatments of 3, 30, 100, and 300 {micro}g/L, respectively. Persistence in the water column was relatively short, with a dissipation half-life estimated at {le} 1.2 d. Persistence of NP in sediment and on macrophytes was substantially longer, with estimated half-lives of 28 to 104 d and 8 to 13 d, respectively. Zooplankton was the most sensitive group of organisms evaluated, with significant reductions in population abundances of some copepod taxa observed at the 23 {+-} 11-{micro}g/L treatment. Fish survival was affected at 243 {+-} 41 {micro}g/L. The most sensitive benthic macroinvertebrate taxon, Pisidium (Bivalvia) was affected at 76 {+-} 21 {micro}g/L, but most taxa were only affected at the 243 {+-} 41-{micro}g/L treatment. None of the assessed populations were affected at the 5 {+-} 4-{micro}g/L treatment. Macrophytes and periphyton were not adversely affected by any of the treatments. Overall community composition, assessed at the family level or higher, was not affected at or below the 23 {+-} 11-{micro}g/L treatment, but did exhibit substantial changes at the 243 {+-} 41-{micro}g/L treatment. Some minor changes were observed at the 76 {+-} 21-{micro}g/L treatment. The maximum acceptable toxicant concentration in the water column, based on protection of the most sensitive taxa in the test system, was estimated at {approximately} 10 {micro}g/L. Details on NP persistence and distribution within the enclosures, and detailed effects on zooplankton, benthic macroinvertebrates, and fish are described in four separate papers immediately following this overview.« less

  7. Decision-Making Styles and Problem-Solving Appraisal.

    ERIC Educational Resources Information Center

    Phillips, Susan D.; And Others

    1984-01-01

    Compared decision-making style and problem-solving appraisal in 243 undergraduates. Results suggested that individuals who employ rational decision-making strategies approach problematic situations, while individuals who endorse dependent decisional strategies approach problematic situations without confidence in their problem-solving abilities.…

  8. 30 CFR 243.200 - How do I demonstrate financial solvency?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... Postal Service or private delivery at P.O. Box 5760, MS 3031, Denver, CO 80217-5760; or (2) Courier or overnight delivery at MS 3031, Denver Federal Center, Bldg. 85, Room A-212, Denver, CO 80225-0165. (b) You...

  9. Mobility Research for Future Vehicles: A Methodology to Create a Unified Trade-Off Environment for Advanced Aerospace Vehicle

    DTIC Science & Technology

    2018-01-31

    Language for SeBBAS ............................................................... 23 2.4.3 Running SeBBAS Algorithm in MATLAB...Input File Error Checking ................................................................................................... 76 4.4.3 Running ...99 6.2 5- Blade Rotor System Investigation

  10. Arkansas 2002 traffic crash statistics

    DOT National Transportation Integrated Search

    2002-01-01

    On all public roads in Arkansas during 2002 there were: : 70,904 total crashes reported, a 3.1 % increase from 2001 : 557 fatal crashes reported, a 3.5 % increase from 2001 : 641 fatalities reported, a 4.9 % increase from 2001 : 243 alcohol/drug rela...

  11. 48 CFR 552.243-71 - Equitable Adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (exclusive of employer's overhead, profit, and any labor cost burdens carried in employer's overhead rate... condition giving rise to entitlement to an equitable adjustment, including increases or decreases to... site, unless separately itemized); (2) Labor cost broken down by trade, employer, occupation, quantity...

  12. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... recklessly engaged in conduct that results in a violation of applicable professional standards, including... Public Company Accounting Oversight Board and the Securities and Exchange Commission; (iii) Has engaged... results in a violation of applicable professional standards in circumstances in which an accountant knows...

  13. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... recklessly engaged in conduct that results in a violation of applicable professional standards, including... Public Company Accounting Oversight Board and the Securities and Exchange Commission; (iii) Has engaged... results in a violation of applicable professional standards in circumstances in which an accountant knows...

  14. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... recklessly engaged in conduct that results in a violation of applicable professional standards, including... Public Company Accounting Oversight Board and the Securities and Exchange Commission; (iii) Has engaged... results in a violation of applicable professional standards in circumstances in which an accountant knows...

  15. 12 CFR 19.243 - Removal, suspension, or debarment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... recklessly engaged in conduct that results in a violation of applicable professional standards, including... Public Company Accounting Oversight Board and the Securities and Exchange Commission; (iii) Has engaged... results in a violation of applicable professional standards in circumstances in which an accountant knows...

  16. The Microclimate of a Tropical Evergreen Forest.

    DTIC Science & Technology

    1980-08-01

    of Human Bioclimate - A Review. World Meteorological Organization Bulletin, Geneva, 56 pp. REFERENCES (con’t) Lee, R., 1978. Forest Micrometeorology...Geophysics, and Bioclimatology , Ser. B 24, 243-251. Pinker, R. (1980): The Microclimate of a dry tropical forest. (Accepted for publication in

  17. Amtrak annual report, 2006

    DOT National Transportation Integrated Search

    2006-01-01

    As a testament to the growing popularity of rail travel, annual ridership has risen every year, growing 12 percent : between FY 2002 and 2006. During the same period, per-passenger-mile revenue yield rose from 23.6 : cents to 26.5 cents. With 24.3 mi...

  18. Raising a question of the privileges of the House.

    THOMAS, 111th Congress

    Rep. Flake, Jeff [R-AZ-6

    2009-05-12

    House - 05/12/2009 On motion to table the measure Agreed to by the Yeas and Nays: 215 - 182, 15 Present (Roll no. 243). (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  19. United States Department of Transportation report to Congress on public-private partnerships, December 2004.

    DOT National Transportation Integrated Search

    2004-12-01

    House Report 108-243 (2003) accompanying the FY 2004 Department of Transportation : Appropriations Act requested the U.S. Department of Transportation (DOT) to prepare a : report identifying the impediments to the formation of large, capital-intensiv...

  20. 40 CFR 421.222 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... times. (c) Vanadium decomposition wet air pollution control. BPT Limitations for the Secondary... pure molybdenum produced Arsenic 48.655 21.650 Chromium 10.243 4.190 Lead 9.778 4.656 Nickel 44.698 29...

  1. 40 CFR 243.204-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... collection system. These records should be used for scheduling maintenance and replacement, for budgeting, and for system evaluation and comparison. (b) The collection system should be reviewed on a regular...) SOLID WASTES GUIDELINES FOR THE STORAGE AND COLLECTION OF RESIDENTIAL, COMMERCIAL, AND INSTITUTIONAL...

  2. Clustering by neurocognition for fine-mapping of the schizophrenia susceptibility loci on chromosome 6p

    PubMed Central

    Lin, Sheng-Hsiang; Liu, Chih-Min; Liu, Yu-Li; Fann, Cathy Shen-Jang; Hsiao, Po-Chang; Wu, Jer-Yuarn; Hung, Shuen-Iu; Chen, Chun-Houh; Wu, Han-Ming; Jou, Yuh-Shan; Liu, Shi K.; Hwang, Tzung J.; Hsieh, Ming H.; Chang, Chien-Ching; Yang, Wei-Chih; Lin, Jin-Jia; Chou, Frank Huang-Chih; Faraone, Stephen V.; Tsuang, Ming T.; Hwu, Hai-Gwo; Chen, Wei J.

    2009-01-01

    Chromosome 6p is one of the most commonly implicated regions in the genome-wide linkage scans of schizophrenia, whereas further association studies for markers in this region were inconsistent likely due to heterogeneity. This study aimed to identify more homogeneous subgroups of families for fine mapping on regions around markers D6S296 and D6S309 (both in 6p24.3) as well as D6S274 (in 6p22.3) by means of similarity in neurocognitive functioning. A total of 160 families of patients with schizophrenia comprising at least two affected siblings who had data for 8 neurocognitive test variables of the Continuous Performance Test (CPT) and the Wisconsin Card Sorting Test (WCST) were subjected to cluster analysis with data visualization using the test scores of both affected siblings. Family clusters derived were then used separately in family-based association tests for 64 single nucleotide polymorphisms covering the region of 6p24.3 and 6p22.3. Three clusters were derived from the family-based clustering, with deficit cluster 1 representing deficit on the CPT, deficit cluster 2 representing deficit on both the CPT and the WCST, and a third cluster of non-deficit. After adjustment using false discovery rate for multiple testing, SNP rs13873 and haplotype rs1225934-rs13873 on BMP6-TXNDC5 genes were significantly associated with schizophrenia for the deficit cluster 1 but not for the deficit cluster 2 or non-deficit cluster. Our results provide further evidence that the BMP6-TXNDC5 locus on 6p24.3 may play a role in the selective impairments on sustained attention of schizophrenia. PMID:19694819

  3. Copy-Number Mutations on Chromosome 17q24.2-q24.3 in Congenital Generalized Hypertrichosis Terminalis with or without Gingival Hyperplasia

    PubMed Central

    Sun, Miao; Li, Ning; Dong, Wu; Chen, Zugen; Liu, Qing; Xu, Yiming; He, Guang; Shi, Yongyong; Li, Xin; Hao, Jiajie; Luo, Yang; Shang, Dandan; Lv, Dan; Ma, Fen; Zhang, Dai; Hua, Rui; Lu, Chaoxia; Wen, Yaran; Cao, Lihua; Irvine, Alan D.; McLean, W.H. Irwin; Dong, Qi; Wang, Ming-Rong; Yu, Jun; He, Lin; Lo, Wilson H.Y.; Zhang, Xue

    2009-01-01

    Congenital generalized hypertrichosis terminalis (CGHT) is a rare condition characterized by universal excessive growth of pigmented terminal hairs and often accompanied with gingival hyperplasia. In the present study, we describe three Han Chinese families with autosomal-dominant CGHT and a sporadic case with extreme CGHT and gingival hyperplasia. We first did a genome-wide linkage scan in a large four-generation family. Our parametric multipoint linkage analysis revealed a genetic locus for CGHT on chromosome 17q24.2-q24.3. Further two-point linkage and haplotyping with microsatellite markers from the same chromosome region confirmed the genetic mapping and showed in all the families a microdeletion within the critical region that was present in all affected individuals but not in unaffected family members. We then carried out copy-number analysis with the Affymetrix Genome-Wide Human SNP Array 6.0 and detected genomic microdeletions of different sizes and with different breakpoints in the three families. We validated these microdeletions by real-time quantitative PCR and confirmed their perfect cosegregation with the disease phenotype in the three families. In the sporadic case, however, we found a de novo microduplication. Two-color interphase FISH analysis demonstrated that the duplication was inverted. These copy-number variations (CNVs) shared a common genomic region in which CNV is not reported in the public database and was not detected in our 434 unrelated Han Chinese normal controls. Thus, pathogenic copy-number mutations on 17q24.2-q24.3 are responsible for CGHT with or without gingival hyperplasia. Our work identifies CGHT as a genomic disorder. PMID:19463983

  4. The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs.

    PubMed

    Hastrup, Hanne; Sen, Namita; Javitch, Jonathan A

    2003-11-14

    Using cysteine cross-linking, we demonstrated previously that the dopamine transporter (DAT) is at least a homodimer, with the extracellular end of transmembrane segment (TM) 6 at a symmetrical dimer interface. We have now explored the possibility that DAT exists as a higher order oligomer in the plasma membrane. Cysteine cross-linking of wild type DAT resulted in bands on SDS-PAGE consistent with dimer, trimer, and tetramer, suggesting that DAT forms a tetramer in the plasma membrane. A cysteine-depleted DAT (CD-DAT) into which only Cys243 or Cys306 was reintroduced was cross-linked to dimer, suggesting that these endogenous cysteines in TM4 and TM6, respectively, were cross-linked at a symmetrical dimer interface. Reintroduction of both Cys243 and Cys306 into CD-DAT led to a pattern of cross-linking indistinguishable from that of wild type, with dimer, trimer, and tetramer bands. This indicated that the TM4 interface and the TM6 interface are distinct and further suggested that DAT may exist in the plasma membrane as a dimer of dimers, with two symmetrical homodimer interfaces. The cocaine analog MFZ 2-12 and other DAT inhibitors, including benztropine and mazindol, protected Cys243 against cross-linking. In contrast, two substrates of DAT, dopamine and tyramine, did not significantly impact cross-linking. We propose that the impairment of cross-linking produced by the inhibitors results from a conformational change at the TM4 interface, further demonstrating that these compounds are not neutral blockers but by themselves have effects on the structure of the transporter.

  5. 28 CFR 35.150 - Existing facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... equipment, reassignment of services to accessible buildings, assignment of aides to beneficiaries, home... alterations to existing buildings, shall meet the accessibility requirements of § 35.151. In choosing among... positions, sections 243 and 1010. (L) Miscellaneous. (1) Team or player seating, section 221.2.1.4. (2...

  6. 28 CFR 35.150 - Existing facilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... equipment, reassignment of services to accessible buildings, assignment of aides to beneficiaries, home... alterations to existing buildings, shall meet the accessibility requirements of § 35.151. In choosing among... positions, sections 243 and 1010. (L) Miscellaneous. (1) Team or player seating, section 221.2.1.4. (2...

  7. 28 CFR 35.150 - Existing facilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... equipment, reassignment of services to accessible buildings, assignment of aides to beneficiaries, home... alterations to existing buildings, shall meet the accessibility requirements of § 35.151. In choosing among... positions, sections 243 and 1010. (L) Miscellaneous. (1) Team or player seating, section 221.2.1.4. (2...

  8. 28 CFR 35.150 - Existing facilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... equipment, reassignment of services to accessible buildings, assignment of aides to beneficiaries, home... alterations to existing buildings, shall meet the accessibility requirements of § 35.151. In choosing among... positions, sections 243 and 1010. (L) Miscellaneous. (1) Team or player seating, section 221.2.1.4. (2...

  9. 40 CFR 761.243 - Standard wipe sample method and size.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND USE PROHIBITIONS Determining a PCB Concentration for Purposes of Abandonment or Disposal of Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe.../Rinse Cleanup as Recommended by the Environmental Protection Agency PCB Spill Cleanup Policy,” dated...

  10. 40 CFR 243.201-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waste handling techniques, and in the proper operation of collection equipment, such as those presented in Operation Responsible: Safe Refuse Collection. (b) Personal protective equipment such as gloves... Standards for Subpart I—Personal Protective Equipment (29 CFR 1910.132 through 1910.137). (c) Scavenging...

  11. 40 CFR 243.201-2 - Recommended procedures: Operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... waste handling techniques, and in the proper operation of collection equipment, such as those presented in Operation Responsible: Safe Refuse Collection. (b) Personal protective equipment such as gloves... Standards for Subpart I—Personal Protective Equipment (29 CFR 1910.132 through 1910.137). (c) Scavenging...

  12. 40 CFR 1051.243 - How do I determine deterioration factors from exhaust durability testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... measure emissions at three or more points, use a linear least-squares fit of your test data for each... points. (2) Operate the vehicle or engine over a representative duty cycle for a period at least as long...

  13. 40 CFR 1051.243 - How do I determine deterioration factors from exhaust durability testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... measure emissions at three or more points, use a linear least-squares fit of your test data for each... points. (2) Operate the vehicle or engine over a representative duty cycle for a period at least as long...

  14. 40 CFR 1051.243 - How do I determine deterioration factors from exhaust durability testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... measure emissions at three or more points, use a linear least-squares fit of your test data for each... points. (2) Operate the vehicle or engine over a representative duty cycle for a period at least as long...

  15. 40 CFR 1051.243 - How do I determine deterioration factors from exhaust durability testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... measure emissions at three or more points, use a linear least-squares fit of your test data for each... points. (2) Operate the vehicle or engine over a representative duty cycle for a period at least as long...

  16. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment and finishing of wine. Agar-agar, carrageenan, cellulose, and diatomaceous earth are commonly employed inert... records need be maintained concerning their use. However, if the inert material is dissolved in water...

  17. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment and finishing of wine. Agar-agar, carrageenan, cellulose, and diatomaceous earth are commonly employed inert... records need be maintained concerning their use. However, if the inert material is dissolved in water...

  18. 27 CFR 24.243 - Filtering aids.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... fibers, pulps, earths, or similar materials, may be used as filtering aids in the cellar treatment and finishing of wine. Agar-agar, carrageenan, cellulose, and diatomaceous earth are commonly employed inert... records need be maintained concerning their use. However, if the inert material is dissolved in water...

  19. Viscosity Measurements of Ethyl Fluoride (R161) from 243 K to 363 K at Pressures up to 30 MPa

    NASA Astrophysics Data System (ADS)

    Meng, Xianyang; Gu, Xiaoyun; Wu, Jiangtao; Bi, Shengshan

    2015-11-01

    The Montreal Protocol and its subsequent amendments have created a schedule to replace ozone depletion substances, such as chlorofluorocarbons and hydrochlorofluorocarbons, with chlorine-free molecules in several industrial applications. Ethyl fluoride (R161, C2H5F, 353-36-6) was found to be a potential alternative refrigerant for the replacement of controlled substances, such as R22 with excellent cycle performance. In this work, the viscosity of ethyl fluoride is reported at temperatures from 243 K to 363 K and at pressures from saturation pressure to 30 MPa. The experiment was performed with a calibrated vibrating-wire viscometer, which exhibited a combined expanded uncertainty of 2.5 % with a level of confidence of 0.95 (k = 2) for such a fluid. A scheme based on a hard-spheres model was used to correlate the experimental results. The average absolute deviation of the experimental results from the correlations for R161 is 0.88 %.

  20. MOBILE Model and Transportation Planning : A Brief Overview

    DOT National Transportation Integrated Search

    2007-01-01

    Americans lose 3.7 billion hours and 2.3 billion gallons of fuel every year sitting in traffic. In 2004, trucks idling in traffic are estimated to have cost the trucking industry some 243 million hours, the equivalent of 17,000 work years, with a cos...

  1. Strategic War Game - Arctic Response

    DTIC Science & Technology

    2010-11-01

    Heather Hrychuk; DRDC CORA TM 2010-240; R & D pour la défense Canada – CARO; Novembre 2010. S1. La section d’Élaboration de concepts et de...10 2.4.3 Scoring System.................................................................................. 13 2.4.3.1 Air Force... 13 2.4.3.2 Adversary

  2. 47 CFR 90.469 - Unattended operation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MOBILE RADIO SERVICES Transmitter Control § 90.469 Unattended operation. (a) Subject to the provisions of §§ 90.243, 90.245, and 90.247, mobile relay, fixed relay, and mobile repeater stations are authorized... where they are activated by either electrical or mechanical devices, provided the licensee adopts...

  3. Near-infrared spectroscopy used to predict soybean seed germination and vigor

    USDA-ARS?s Scientific Manuscript database

    The potential of using near-infrared (NIR) spectroscopy for differentiating levels in germination, vigor, and electrical conductivity of soybean seeds was investigated. For the 243 spectral data collected using the Perten DA7200, stratified sampling was used to obtain three calibration sets consisti...

  4. 75 FR 11834 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... for animal disease spread models. Without this type of data, the ability to detect trends in..., veterinary, and industry reference; (2) Predict or detect national trends in disease emergence and movement.... Description of Respondents: Business or other for-profit. Number of Respondents: 22,243. Frequency of...

  5. 48 CFR 1852.243-72 - Equitable adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... subsequently granted. The proposal shall provide an itemized breakdown of all increases and decreases in the... and costs; direct labor hours and rates for each trade; the associated FICA, FUTA, SUTA, and Workmen's... profit on work performed by others. The percentages for overhead, profit, and commission are negotiable...

  6. 78 FR 46926 - Procurement List Additions and Deletions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... Oklahoma City Air Logistics Center (FA8126 AFSC PZIMB), Tinker Air Force Base, OK. Services Service Type... Center, 1876 Wasp Blvd., Honolulu, HI. NPA: Lanakila Pacific, Honolulu, HI Contracting Activity: Dept of...: 5210-00-243-3349 NPA: Northeastern Michigan Rehabilitation and Opportunity Center (NEMROC), Alpena, MI...

  7. Venus - Comparison of Left and Right Looking Views of Imdr Region

    NASA Image and Video Library

    1996-03-14

    As NASA Magellan mission progressed, areas of Venus became accessible for a second look. During Magellan second 243-day global mapping cycle, the spacecraft was rotated 180 degrees to view the surface from the opposite direction. http://photojournal.jpl.nasa.gov/catalog/PIA00260

  8. 78 FR 18285 - General Services Administration Acquisition Regulation; Submission for OMB Review; Modifications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ...; Modifications 552.243-72 (Multiple Award Schedules) AGENCY: Office of Acquisition Policy, General Services... information collection requirement regarding the Modifications (Multiple Award Schedule) clause. DATES: Submit comments on or before: April 25, 2013. FOR FURTHER INFORMATION CONTACT: Ms. Dana Munson, General Services...

  9. Work-Family Balance and Psychosocial Adjustment of Married International Students

    ERIC Educational Resources Information Center

    Bulgan, Gökçe; Çiftçi, Ayse

    2018-01-01

    The authors investigated how work-family balance mediated the relationship between personality traits, gender roles, social support, and psychosocial adjustment. Data were collected from 243 married international graduate students (MIGSs) studying in the United States. Results of structural equation modeling indicated that personality traits…

  10. 78 FR 57156 - General Services Administration Acquisition Regulation; Submission for OMB Review; Modifications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... Supply Schedules) AGENCY: Office of Acquisition Policy, General Services Administration (GSA). ACTION... collection requirement regarding the Modifications (Federal Supply Schedule) clause. DATES: Submit comments... (GSAR) to add clause 552.243-81 Modifications (Federal Supply Schedule) and an Alternate I version of...

  11. Northwestern Argentina as seen from the Apollo 7 spacecraft

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Puna de Atacama area of northwestern Argentina, Provinces of Salta and Catamarca, as seen from the Apollo 7 spacecraft during its 154th revolution of the earth. Photographed from an altitude of 175 nautical miles, at ground elapsed time of 243 hours and 58 minutes.

  12. 40 CFR 243.202-1 - Requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... solid waste (or materials which have been separated for the purpose of recycling) which are considered... transportation of solid waste (or materials which have been separated for the purpose of recycling) shall be... materials which have been separated for the purpose of recycling) shall be constructed, operated, and...

  13. 40 CFR 243.202-1 - Requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... solid waste (or materials which have been separated for the purpose of recycling) which are considered... transportation of solid waste (or materials which have been separated for the purpose of recycling) shall be... materials which have been separated for the purpose of recycling) shall be constructed, operated, and...

  14. 40 CFR 243.202-1 - Requirement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... solid waste (or materials which have been separated for the purpose of recycling) which are considered... transportation of solid waste (or materials which have been separated for the purpose of recycling) shall be... materials which have been separated for the purpose of recycling) shall be constructed, operated, and...

  15. 40 CFR 243.202-1 - Requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... solid waste (or materials which have been separated for the purpose of recycling) which are considered... transportation of solid waste (or materials which have been separated for the purpose of recycling) shall be... materials which have been separated for the purpose of recycling) shall be constructed, operated, and...

  16. 40 CFR 243.202-1 - Requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... solid waste (or materials which have been separated for the purpose of recycling) which are considered... transportation of solid waste (or materials which have been separated for the purpose of recycling) shall be... materials which have been separated for the purpose of recycling) shall be constructed, operated, and...

  17. 47 CFR 90.243 - Mobile relay stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND... Service. (b) Special provisions for mobile relay operations: (1) In the Public Safety Pool, systems operating on any of the public safety frequencies listed in § 90.20(c) are permitted to be cross-banded for...

  18. ERCMExpress. Volume 1, Issue 1

    ERIC Educational Resources Information Center

    US Department of Education, 2005

    2005-01-01

    This is the inaugural issue of the Emergency Response and Crisis Management (ERCM) Technical Assistance Center's "ERCMExpress," and it focuses on the new technical assistance center. The center will support 243 grantees funded under the Emergency Response and Crisis Management program in managing and implementing their projects, and in sustaining…

  19. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) The floors in the eviscerating room shall be kept clean and reasonably dry during eviscerating... accord with clean and sanitary methods. (a) There shall be no handling or storing of materials which create an objectionable condition in rooms, compartments, or other places in the plant where any product...

  20. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) The floors in the eviscerating room shall be kept clean and reasonably dry during eviscerating... accord with clean and sanitary methods. (a) There shall be no handling or storing of materials which create an objectionable condition in rooms, compartments, or other places in the plant where any product...

  1. 9 CFR 354.243 - Operations and procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) The floors in the eviscerating room shall be kept clean and reasonably dry during eviscerating... accord with clean and sanitary methods. (a) There shall be no handling or storing of materials which create an objectionable condition in rooms, compartments, or other places in the plant where any product...

  2. 12 CFR 243.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the United States; (ii) Controls a bank in the United States; or (iii) Controls an Edge corporation... Board and for which such determination is still in effect. (o) Rapid and orderly resolution means a... failure of the covered company would have serious adverse effects on financial stability in the United...

  3. 12 CFR 243.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the United States; (ii) Controls a bank in the United States; or (iii) Controls an Edge corporation... Board and for which such determination is still in effect. (o) Rapid and orderly resolution means a... failure of the covered company would have serious adverse effects on financial stability in the United...

  4. 12 CFR 243.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the United States; (ii) Controls a bank in the United States; or (iii) Controls an Edge corporation... Board and for which such determination is still in effect. (o) Rapid and orderly resolution means a... failure of the covered company would have serious adverse effects on financial stability in the United...

  5. 47 CFR 24.247 - Triggering a reimbursement obligation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990... relocator or a voluntarily relocating microwave incumbent in accordance with the formula detailed in § 24.243: (1) All or part of the relocated microwave link was initially co-channel with the licensed PCS...

  6. 47 CFR 24.247 - Triggering a reimbursement obligation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990... relocator or a voluntarily relocating microwave incumbent in accordance with the formula detailed in § 24.243: (1) All or part of the relocated microwave link was initially co-channel with the licensed PCS...

  7. 47 CFR 24.247 - Triggering a reimbursement obligation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990... relocator or a voluntarily relocating microwave incumbent in accordance with the formula detailed in § 24.243: (1) All or part of the relocated microwave link was initially co-channel with the licensed PCS...

  8. 47 CFR 24.247 - Triggering a reimbursement obligation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990... relocator or a voluntarily relocating microwave incumbent in accordance with the formula detailed in § 24.243: (1) All or part of the relocated microwave link was initially co-channel with the licensed PCS...

  9. Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study.

    PubMed

    Rio, Alan; Whelan, Kevin; Goff, Louise; Reidlinger, Dianne Patricia; Smeeton, Nigel

    2013-01-11

    Refeeding syndrome is a potentially life-threatening condition characterised by severe intracellular electrolyte shifts, acute circulatory fluid overload and organ failure. The initial symptoms are non-specific but early clinical features are severely low-serum electrolyte concentrations of potassium, phosphate or magnesium. Risk factors for the syndrome include starvation, chronic alcoholism, anorexia nervosa and surgical interventions that require lengthy periods of fasting. The causes of the refeeding syndrome are excess or unbalanced enteral, parenteral or oral nutritional intake. Prevention of the syndrome includes identification of individuals at risk, controlled hypocaloric nutritional intake and supplementary electrolyte replacement. To determine the occurrence of refeeding syndrome in adults commenced on artificial nutrition support. Prospective cohort study. Large, single site university teaching hospital. Recruitment period 2007-2009. 243 adults started on artificial nutrition support for the first time during that admission recruited from wards and intensive care. occurrence of the refeeding syndrome. Secondary outcome: analysis of the risk factors which predict the refeeding syndrome. Tertiary outcome: mortality due to refeeding syndrome and all-cause mortality. 133 participants had one or more of the following risk factors: body mass index <16-18.5≥(kg/m(2)), unintentional weight loss >15% in the preceding 3-6 months, very little or no nutritional intake >10 days, history of alcohol or drug abuse and low baseline levels of serum potassium, phosphate or magnesium prior to recruitment. Poor nutritional intake for more than 10 days, weight loss >15% prior to recruitment and low-serum magnesium level at baseline predicted the refeeding syndrome with a sensitivity of 66.7%: specificity was >80% apart from weight loss of >15% which was 59.1%. Baseline low-serum magnesium was an independent predictor of the refeeding syndrome (p=0.021). Three participants (2% 3/243) developed severe electrolyte shifts, acute circulatory fluid overload and disturbance to organ function following artificial nutrition support and were diagnosed with refeeding syndrome. There were no deaths attributable to the refeeding syndrome, but (5.3% 13/243) participants died during the feeding period and (28% 68/243) died during hospital admission. Death of these participants was due to cerebrovascular accident, traumatic injury, respiratory failure, organ failure or end-of-life causes. Refeeding syndrome was a rare, survivable phenomenon that occurred during hypocaloric nutrition support in participants identified at risk. Independent predictors for refeeding syndrome were starvation and baseline low-serum magnesium concentration. Intravenous carbohydrate infusion prior to artificial nutrition support may have precipitated the onset of the syndrome.

  10. A clinical investigation of the efficacy of two dentifrices for the reduction of supragingival calculus formation.

    PubMed

    Schiff, Thomas; Delgado, Evaristo; DeVizio, William; Proskin, Howard M

    2008-01-01

    The objective of this double-blind clinical study, conducted in harmony with Volpe-Manhold design for studies of dental calculus, was to compare the efficacy of a dentifrice containing 0.3% triclosan/2.0% polyvinylmethyl ether/maleic acid (PVM/MA) copolymer/0.243% sodium fluoride in a 17% dual silica base (Colgate Total Advanced Toothpaste) to that of a commercially available dentifrice containing 0.243% sodium fluoride in a silica base (Crest Cavity Protection Toothpaste) with respect to the reduction of supragingival calculus formation. Adult male and female subjects from the San Francisco area were entered into the eight-week pre-test phase of the study. Subjects received an evaluation of oral soft and hard tissues and were given a complete oral prophylaxis. They were provided with a non-tartar control placebo dentifrice and a soft-bristled adult toothbrush, and were instructed to brush their teeth twice daily (morning and evening) for one minute. After eight weeks of using the placebo dentifrice, subjects were examined for baseline supragingival calculus formation using the Volpe-Manhold Calculus Index. Qualifying subjects were randomized into two treatment groups which were balanced for gender and baseline calculus scores. All subjects entered into the twelve-week test phase were given a complete oral prophylaxis, and were provided with their assigned dentifrice and a soft-bristled adult toothbrush for home use. Subjects were instructed to brush their teeth for one minute twice daily (in the morning and evening). Prior to each study visit, subjects refrained from brushing their teeth and eating and drinking for four hours. Seventy-seven (77) subjects complied with the protocol and completed the study. At the twelve-week examination, the Test Dentifrice group presented a mean Volpe-Manhold Calculus Index score of 13.22 and the Control Dentifrice group presented a score of 20.29. After twelve weeks of product use, the Test Dentifrice group exhibited 34.8% less supragingival calculus formation than the Control Dentifrice group (statistically significant at p < 0.05). The overall results of this double-blind clinical study support the conclusion that after twelve weeks' use of a dentifrice containing 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride in a 17% dual silica base provides significantly greater control of supragingival calculus formation relative to that of a commercially available dentifrice containing 0.243% sodium fluoride in a silica base.

  11. 76 FR 61057 - Revisions to the California State Implementation Plan, Sacramento Metropolitan Air Quality...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... compound (VOC) emissions from organic chemical manufacturing, soil decontamination, and polyester resin... 74.29 Soil Decontamination Operations 04/08/08 01/10/10 PCAPCD 243 Polyester Resin Operations..... 04....29 establishes procedures for the treatment of soil contaminated with gasoline, diesel fuel or jet...

  12. 48 CFR 552.243-71 - Equitable Adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Markups. (3) Change to the time for completion specified in the contract. (e) Direct costs. The Contractor... contract regarding the Contractor's project schedule. (h) Markups. For each firm whose direct costs are... applicable, a bond rate and insurance rate. Markups shall be determined and applied as follows: (1) Overhead...

  13. 78 FR 65370 - Notice of Inventory Completion: Pima County Office of the Medical Examiner, Tucson, AZ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ... Office for forensic analysis. The Pinal County Medical Examiner, Dr Rebecca Hsu, transferred the remains... were transferred to Pinal County Medical Examiner's Office for forensic analysis. The Pinal County.... Bruce Anderson, Forensic Anthropologist, PCOME, Tucson, AZ 85714, telephone (520) 243-8600...

  14. 76 FR 9409 - National Emission Standards for Hazardous Air Pollutants: Primary Lead Smelting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... at EPA's campus in Research Triangle Park, North Carolina, or at an alternate facility nearby... Programs Division, Metals and Minerals Group (D243-02), U.S. Environmental Protection Agency, Research...-02), Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, Research...

  15. 40 CFR 98.244 - Monitoring and QA/QC requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... procedures specified in § 98.34(c). (b) If you use the mass balance methodology in § 98.243(c), use the... Test Methods for Instrumental Determination of Carbon, Hydrogen, and Nitrogen in Petroleum Products and... Instrumental Determination of Carbon, Hydrogen, and Nitrogen in Laboratory Samples of Coal (incorporated by...

  16. 40 CFR 98.244 - Monitoring and QA/QC requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... procedures specified in § 98.34(c). (b) If you use the mass balance methodology in § 98.243(c), use the...) Standard Test Methods for Instrumental Determination of Carbon, Hydrogen, and Nitrogen in Petroleum... for Instrumental Determination of Carbon, Hydrogen, and Nitrogen in Laboratory Samples of Coal...

  17. A Longitudinal Study of Total Quality Management Processes in Business Colleges.

    ERIC Educational Resources Information Center

    Vazzana, Gary; Elfrink, John; Bachmann, Duane P.

    2000-01-01

    Surveys of business school deans in 1995 (n=243) and 1998 (n=151) regarding total quality management (TQM) practices revealed increases in mission and strategy development, goal setting, and use of advisory boards and cross-functional teams. Few are using TQM to manage core learning processes. (SK)

  18. 76 FR 72225 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    .... Independent public accountants must verify the fund's assets at least three times a year and two of the... independent public accountants when they perform verifications of fund assets.\\4\\ Approximately 243 funds rely... hours per fund) x $165 (fund senior accountant's hourly rate) = $82.50. \\3\\ Respondents estimated that...

  19. Consequences of Parental Divorce and Marital Unhappiness for Adult Well-Being.

    ERIC Educational Resources Information Center

    Amato, Paul R.; Booth, Alan

    1991-01-01

    Among 1,243 adults nationwide, individuals who experienced parental divorce as children scored lower than those from happily intact families of origin on measures of psychological, social, and marital well-being. Multiple parental divorces and divorces involving deterioration of parent-child relations appeared particularly problematic. Contains 39…

  20. The Needs of Families: Results of a Statewide Survey in Massachusetts.

    ERIC Educational Resources Information Center

    Agosta, John M.; And Others

    The report presents findings from a survey of 243 caregiving families in Massachusetts which explored family needs and characteristics, as well as those of their developmentally disabled family members. Survey questions focused on family information, characteristics of the disabled family member, information on family needs, care-related costs…

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