Sample records for einsteinium 247

  1. Einsteinium

    NASA Astrophysics Data System (ADS)

    Haire, Richard G.

    The discovery of einsteinium, element 99, came about during the analyses of nuclear products produced in and then recovered from test debris following a thermonuclear explosion (weapon test device, ‘Mike', November 1952) at Eniwetok Atoll in the Pacific Ocean. The uranium present in this device was subjected to a very intense neutron flux (integrated fluence of about 1024neutrons) in an extremely short time frame (few nanoseconds), which allowed a large number of multiple neutron captures with a minimal degree of decay of the products formed. Nuclei were formed with usually high neutron/proton ratios (very ‘heavy' uranium isotopes), which then rapidly beta-decayed into new, transuranium isotopes through element 100. Scientists from several U.S. Government laboratories separated and analyzed extensively the debris samplings in the following weeks. From these investigations came the discovery and identification of einsteinium and fermium. The first element was named in honor of Albert Einstein, and assigned the symbol, E (later changed to the current symbol, Es). Additional details and discussions about the discovery of this element and the scientists involved are given in several references (Thompson et al., 1954; Ghiorso et al., 1955; Fields et al., 1956; Hyde et al., 1964; Seaborg and Loveland, 1990).

  2. Chemical Properties of Elements 99 and 100 [Einsteinium and Fermium

    DOE R&D Accomplishments Database

    Seaborg, G. T.; Thompson, S. G.; Harvey, B. G.; Choppin, G. R.

    1954-07-23

    A description of some of the chemical properties and of the methods used in the separations of elements 99 [Einsteinium] and 100 [Fermium] are given. The new elements exhibit the properties expected for the tenth and eleventh actinide elements. Attempts to produce an oxidation state greater than III of element 99 have been unsuccessful. In normal aqueous media only the III state of element 100 appears to exist. The relative spacings of the elution peaks of the new elements in some separations with ion exchange resin columns are the same as the relative spacings of the homologous lanthanide elements. The results of experiments involving cation exchange resins with very concentrated hydrochloric acid eluant show that the new elements, like the earlier actinides, are more strongly complexed than the lanthanides. The new elements also exist partially as anions in concentrated hydrochloric acid, as do earlier actinide elements, and they may be partially separated from each other by means of ion exchange resins. With some eluants interesting reversals of elution positions are observed in the region Bk-Cf-99-100, indicating complex ion formation involving unusual factors.

  3. BAG PASSOUT SEALER FOR WATER-SHIELDED CAVE FACILITY (Engineering Materials)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1963-10-31

    The water-shielded cave facility is used in processing irradiated slugs for recovery of americium, curium, berkelium, californium, einsteinium, and fermium. The remotely operated, plastic-bag passout sealer is used in removing isotopic fractions for storage in the rear or for removing radioactive waste for placement in the waste storage containers. The unit is accessible by both the primary inclosure master-slaves and the service area master-slaves. (F.L.S.)

  4. Handbook of Basic Atomic Spectroscopic Data

    National Institute of Standards and Technology Data Gateway

    SRD 108 Handbook of Basic Atomic Spectroscopic Data (Web, free access)   This handbook provides a selection of the most important and frequently used atomic spectroscopic data. The compilation includes data for the neutral and singly-ionized atoms of all elements hydrogen through einsteinium (Z = 1-99). The wavelengths, intensities, and spectrum assignments are given for each element, and the data for the approximately 12,000 lines of all elements are also collected into a single table.

  5. Systematization of actinides using cluster analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kopyrin, A.A.; Terent`eva, T.N.; Khramov, N.N.

    1994-11-01

    A representation of the actinides in multidimensional property space is proposed for systematization of these elements using cluster analysis. Literature data for their atomic properties are used. Owing to the wide variation of published ionization potentials, medians are used to estimate them. Vertical dendograms are used for classification on the basis of distances between the actinides in atomic-property space. The properties of actinium and lawrencium are furthest removed from the main group. Thorium and mendelevium exhibit individualized properties. A cluster based on the einsteinium-fermium pair is joined by californium.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nesaraja, C.D.

    Available information pertaining to the nuclear structure of all nuclei with mass numbers A=247 is presented. Various decay and reaction data are evaluated and compared. Adopted data, levels, spin, parity and configuration assignments are given. When there are insufficient data, expected values from systematics of nuclear properties or/and theoretical calculations are quoted. Unexpected or discrepant experimental results are also noted. A summary and compilation of the discovery of various isotopes in this mass region is given in 2013Fr02 ({sup 247}Pu, {sup 247}Am, {sup 247}Cm, {sup 243}Bk, {sup 247}Cf), 2011Me01 ({sup 247}Es), and 2013Th02 ({sup 247}Fm, {sup 247}Md)

  7. 48 CFR 252.247-7023 - Transportation of supplies by sea.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... by sea. 252.247-7023 Section 252.247-7023 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.247-7023 Transportation of supplies by sea. As prescribed in 247.573(b)(1), use the following clause: Transportation of Supplies by Sea (MAY 2002) (a) Definitions. As used...

  8. 48 CFR 252.247-7023 - Transportation of supplies by sea.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... by sea. 252.247-7023 Section 252.247-7023 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.247-7023 Transportation of supplies by sea. As prescribed in 247.573(b)(1), use the following clause: Transportation of Supplies by Sea (MAY 2002) (a) Definitions. As used...

  9. 48 CFR 252.247-7023 - Transportation of supplies by sea.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... by sea. 252.247-7023 Section 252.247-7023 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.247-7023 Transportation of supplies by sea. As prescribed in 247.574(b)(1), use the following clause: Transportation of Supplies by Sea (JUN 2013) (a) Definitions. As used...

  10. 48 CFR 252.247-7023 - Transportation of supplies by sea.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... by sea. 252.247-7023 Section 252.247-7023 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.247-7023 Transportation of supplies by sea. As prescribed in 247.573(b)(1), use the following clause: Transportation of Supplies by Sea (MAY 2002) (a) Definitions. As used...

  11. 48 CFR 252.247-7023 - Transportation of supplies by sea.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... by sea. 252.247-7023 Section 252.247-7023 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.247-7023 Transportation of supplies by sea. As prescribed in 247.574(b.... Transportation of Supplies by Sea—Basic (APR 2014) (a) Definitions. As used in this clause— Components means...

  12. 48 CFR 252.247-7016 - Contractor liability for loss or damage.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... loss or damage. 252.247-7016 Section 252.247-7016 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.247-7016 Contractor liability for loss or damage. As prescribed in 247.270-3(k), use the following clause: Contractor Liability for Loss or Damage (DEC 1991) (a...

  13. 40 CFR 247.5 - Specifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Specifications. 247.5 Section 247.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.5 Specifications. (a) RCRA section 6002...

  14. 40 CFR 247.4 - Contracting officer requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Contracting officer requirements. 247.4 Section 247.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.4 Contracting...

  15. 40 CFR 247.6 - Affirmative procurement programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Affirmative procurement programs. 247.6 Section 247.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.6 Affirmative...

  16. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.7...

  17. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.7...

  18. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.7...

  19. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.7...

  20. 32 CFR 247.7 - Information requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Information requirements. 247.7 Section 247.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.7...

  1. 48 CFR 252.247-7015 - Requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Requirements. 252.247-7015 Section 252.247-7015 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Clauses 252.247-7015 Requirements. As prescribed in 216.506(d), substitute the following paragraph (f) for...

  2. 48 CFR 252.247-7015 - Requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Requirements. 252.247-7015 Section 252.247-7015 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Clauses 252.247-7015 Requirements. As prescribed in 216.506(d), substitute the following paragraph (f) for...

  3. 48 CFR 252.247-7015 - Requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Requirements. 252.247-7015 Section 252.247-7015 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Clauses 252.247-7015 Requirements. As prescribed in 216.506(d), substitute the following paragraph (f) for...

  4. 7 CFR 247.18 - Nutrition education.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition education. 247.18 Section 247.18 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.18 Nutrition education. (a) What are...

  5. 7 CFR 247.18 - Nutrition education.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Nutrition education. 247.18 Section 247.18 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.18 Nutrition education. (a) What are...

  6. 7 CFR 247.18 - Nutrition education.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Nutrition education. 247.18 Section 247.18 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.18 Nutrition education. (a) What are...

  7. 7 CFR 247.18 - Nutrition education.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Nutrition education. 247.18 Section 247.18 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.18 Nutrition education. (a) What are...

  8. 7 CFR 247.18 - Nutrition education.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Nutrition education. 247.18 Section 247.18 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.18 Nutrition education. (a) What are...

  9. 7 CFR 247.27 - Financial management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Financial management. 247.27 Section 247.27... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.27 Financial management. (a) What are the Federal requirements for State and local agencies with regard to financial management...

  10. 7 CFR 247.27 - Financial management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Financial management. 247.27 Section 247.27... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.27 Financial management. (a) What are the Federal requirements for State and local agencies with regard to financial management...

  11. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  12. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  13. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  14. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  15. 7 CFR 247.4 - Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Agreements. 247.4 Section 247.4 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.4 Agreements. (a) What agreements are necessary for agencies to administer CSFP? The following agreements are necessary for agencies to administer...

  16. 24 CFR 247.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CERTAIN SUBSIDIZED AND HUD-OWNED PROJECTS Subsidized Projects § 247.2 Definitions. Drug-related criminal... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Definitions. 247.2 Section 247.2 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF...

  17. 7 CFR 247.27 - Financial management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management. 247.27 Section 247.27... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.27 Financial management. (a) What are the Federal requirements for State and local agencies with regard to financial management...

  18. 7 CFR 247.34 - Management reviews.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Management reviews. 247.34 Section 247.34 Agriculture... CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.34 Management reviews. (a) What must... agency must establish a management review system to ensure that local agencies, subdistributing agencies...

  19. 40 CFR 247.14 - Park and recreation products.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Park and recreation products. 247.14 Section 247.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.14 Park...

  20. 40 CFR 247.7 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Effective date. 247.7 Section 247.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.7 Effective date. Within one year after...

  1. 40 CFR 247.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Purpose and scope. 247.1 Section 247.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS General § 247.1 Purpose and scope. (a) The purpose of...

  2. 47 CFR 90.247 - Mobile repeater stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of the mobile unit and an automatic time-delay device that de-activates the transmitter after any... 47 Telecommunication 5 2010-10-01 2010-10-01 false Mobile repeater stations. 90.247 Section 90.247... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.247 Mobile repeater stations. A...

  3. 48 CFR 52.247-24 - Advance Notification by the Government.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... when the Government is responsible for notifying the contractor of specific service times or unusual... the Government. 52.247-24 Section 52.247-24 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.247-24 Advance Notification by the Government. As prescribed in 47.207-8(a)(1), insert the...

  4. 48 CFR 52.247-24 - Advance Notification by the Government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... when the Government is responsible for notifying the contractor of specific service times or unusual... the Government. 52.247-24 Section 52.247-24 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.247-24 Advance Notification by the Government. As prescribed in 47.207-8(a)(1), insert the...

  5. 9 CFR 354.247 - Table showing types of materials.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Table showing types of materials. 354.247 Section 354.247 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Sanitary Conditions and Precautions Against Contamination of Products § 354.247 Table showing types of...

  6. 48 CFR 247.370 - DD Form 1384, Transportation Control and Movement Document.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1384, Transportation Control and Movement Document. 247.370 Section 247.370 Federal Acquisition Regulations System... Transportation in Supply Contracts 247.370 DD Form 1384, Transportation Control and Movement Document. The...

  7. 42 CFR 24.7 - Performance appraisal system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Performance appraisal system. 24.7 Section 24.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.7 Performance appraisal system. The members of the Service shall be subject to a...

  8. 42 CFR 24.7 - Performance appraisal system.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Performance appraisal system. 24.7 Section 24.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.7 Performance appraisal system. The members of the Service shall be subject to a...

  9. 42 CFR 24.7 - Performance appraisal system.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Performance appraisal system. 24.7 Section 24.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.7 Performance appraisal system. The members of the Service shall be subject to a...

  10. 42 CFR 24.7 - Performance appraisal system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Performance appraisal system. 24.7 Section 24.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.7 Performance appraisal system. The members of the Service shall be subject to a...

  11. 42 CFR 24.7 - Performance appraisal system.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Performance appraisal system. 24.7 Section 24.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.7 Performance appraisal system. The members of the Service shall be subject to a...

  12. 12 CFR 24.7 - Examination, records, and remedial action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Examination, records, and remedial action. 24.7 Section 24.7 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY COMMUNITY AND ECONOMIC DEVELOPMENT ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.7...

  13. 48 CFR 52.247-2 - Permits, Authorities, or Franchises.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Franchises. 52.247-2 Section 52.247-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-2 Permits, Authorities, or Franchises. As prescribed in 47.207-1(a), insert the following clause: Permits, Authorities, or Franchises (JAN 1997) (a) The offeror does □, does not □, hold authorization from...

  14. 48 CFR 52.247-2 - Permits, Authorities, or Franchises.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Franchises. 52.247-2 Section 52.247-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-2 Permits, Authorities, or Franchises. As prescribed in 47.207-1(a), insert the following clause: Permits, Authorities, or Franchises (JAN 1997) (a) The offeror does □, does not □, hold authorization from...

  15. 48 CFR 52.247-2 - Permits, Authorities, or Franchises.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Franchises. 52.247-2 Section 52.247-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-2 Permits, Authorities, or Franchises. As prescribed in 47.207-1(a), insert the following clause: Permits, Authorities, or Franchises (JAN 1997) (a) The offeror does □, does not □, hold authorization from...

  16. 48 CFR 52.247-2 - Permits, Authorities, or Franchises.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Franchises. 52.247-2 Section 52.247-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-2 Permits, Authorities, or Franchises. As prescribed in 47.207-1(a), insert the following clause: Permits, Authorities, or Franchises (JAN 1997) (a) The offeror does □, does not □, hold authorization from...

  17. 48 CFR 52.247-2 - Permits, Authorities, or Franchises.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Franchises. 52.247-2 Section 52.247-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-2 Permits, Authorities, or Franchises. As prescribed in 47.207-1(a), insert the following clause: Permits, Authorities, or Franchises (JAN 1997) (a) The offeror does □, does not □, hold authorization from...

  18. 7 CFR 947.247 - Assessment rate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 947.247 Section 947.247 Agriculture... SISKIYOU COUNTIES, CALIF., AND IN ALL COUNTIES IN OREGON, EXCEPT MALHEUR COUNTY Reports Assessment Rates § 947.247 Assessment rate. On and after July 1, 1997, an assessment rate of $0.004 per hundredweight is...

  19. 7 CFR 947.247 - Assessment rate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Assessment rate. 947.247 Section 947.247 Agriculture... SISKIYOU COUNTIES, CALIF., AND IN ALL COUNTIES IN OREGON, EXCEPT MALHEUR COUNTY Reports Assessment Rates § 947.247 Assessment rate. On and after July 1, 1997, an assessment rate of $0.004 per hundredweight is...

  20. 7 CFR 947.247 - Assessment rate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Assessment rate. 947.247 Section 947.247 Agriculture... SISKIYOU COUNTIES, CALIF., AND IN ALL COUNTIES IN OREGON, EXCEPT MALHEUR COUNTY Reports Assessment Rates § 947.247 Assessment rate. On and after July 1, 1997, an assessment rate of $0.004 per hundredweight is...

  1. 7 CFR 947.247 - Assessment rate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 947.247 Section 947.247 Agriculture... SISKIYOU COUNTIES, CALIF., AND IN ALL COUNTIES IN OREGON, EXCEPT MALHEUR COUNTY Reports Assessment Rates § 947.247 Assessment rate. On and after July 1, 1997, an assessment rate of $0.004 per hundredweight is...

  2. 7 CFR 947.247 - Assessment rate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Assessment rate. 947.247 Section 947.247 Agriculture... SISKIYOU COUNTIES, CALIF., AND IN ALL COUNTIES IN OREGON, EXCEPT MALHEUR COUNTY Reports Assessment Rates § 947.247 Assessment rate. On and after July 1, 1997, an assessment rate of $0.004 per hundredweight is...

  3. 48 CFR 852.247-70 - Determining transportation costs for bid evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... costs for bid evaluation. 852.247-70 Section 852.247-70 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 852.247-70 Determining transportation costs for bid evaluation. As prescribed in 847...

  4. 7 CFR 247.7 - Selection of local agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Selection of local agencies. 247.7 Section 247.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.7 Selection of local agencies...

  5. 7 CFR 247.37 - Civil rights requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Civil rights requirements. 247.37 Section 247.37... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.37 Civil rights requirements. (a) What are the civil rights requirements that apply to CSFP? State and local agencies must comply...

  6. 48 CFR 252.247-7001 - Price adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Price adjustment. 252.247... Clauses 252.247-7001 Price adjustment. As prescribed in 247.270-4(b), use the following clause: Price Adjustment (JAN 1997) (a) The Contractor warrants that the prices set forth in this contract— (1) Are based...

  7. 48 CFR 252.247-7024 - Notification of transportation of supplies by sea.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... transportation of supplies by sea. 252.247-7024 Section 252.247-7024 Federal Acquisition Regulations System... supplies by sea. As prescribed in 247.574(c), use the following clause: Notification of Transportation of Supplies by Sea (MAR 2000) (a) The Contractor has indicated by the response to the solicitation provision...

  8. 48 CFR 252.247-7024 - Notification of transportation of supplies by sea.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... transportation of supplies by sea. 252.247-7024 Section 252.247-7024 Federal Acquisition Regulations System... supplies by sea. As prescribed in 247.574(c), use the following clause: Notification of Transportation of Supplies by Sea (MAR 2000) (a) The Contractor has indicated by the response to the solicitation provision...

  9. 48 CFR 252.247-7022 - Representation of extent of transportation by sea.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of transportation by sea. 252.247-7022 Section 252.247-7022 Federal Acquisition Regulations System... transportation by sea. As prescribed in 247.574(a), use the following provision: Representation of Extent of Transportation By Sea (AUG 1992) (a) The Offeror shall indicate by checking the appropriate blank in paragraph (b...

  10. 48 CFR 252.247-7022 - Representation of extent of transportation by sea.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of transportation by sea. 252.247-7022 Section 252.247-7022 Federal Acquisition Regulations System... transportation by sea. As prescribed in 247.574(a), use the following provision: Representation of Extent of Transportation By Sea (AUG 1992) (a) The Offeror shall indicate by checking the appropriate blank in paragraph (b...

  11. 48 CFR 252.247-7022 - Representation of extent of transportation by sea.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of transportation by sea. 252.247-7022 Section 252.247-7022 Federal Acquisition Regulations System... transportation by sea. As prescribed in 247.574(a), use the following provision: Representation of Extent of Transportation By Sea (AUG 1992) (a) The Offeror shall indicate by checking the appropriate blank in paragraph (b...

  12. 48 CFR 252.247-7024 - Notification of transportation of supplies by sea.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... transportation of supplies by sea. 252.247-7024 Section 252.247-7024 Federal Acquisition Regulations System... supplies by sea. As prescribed in 247.574(c), use the following clause: Notification of Transportation of Supplies by Sea (MAR 2000) (a) The Contractor has indicated by the response to the solicitation provision...

  13. 48 CFR 252.247-7022 - Representation of extent of transportation by sea.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of transportation by sea. 252.247-7022 Section 252.247-7022 Federal Acquisition Regulations System... transportation by sea. As prescribed in 247.574(a), use the following provision: Representation of Extent of Transportation By Sea (AUG 1992) (a) The Offeror shall indicate by checking the appropriate blank in paragraph (b...

  14. 48 CFR 252.247-7024 - Notification of transportation of supplies by sea.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... transportation of supplies by sea. 252.247-7024 Section 252.247-7024 Federal Acquisition Regulations System... supplies by sea. As prescribed in 247.574(c), use the following clause: Notification of Transportation of Supplies by Sea (MAR 2000) (a) The Contractor has indicated by the response to the solicitation provision...

  15. 48 CFR 252.247-7024 - Notification of transportation of supplies by sea.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... transportation of supplies by sea. 252.247-7024 Section 252.247-7024 Federal Acquisition Regulations System... supplies by sea. As prescribed in 247.574(c), use the following clause: Notification of Transportation of Supplies by Sea (MAR 2000) (a) The Contractor has indicated by the response to the solicitation provision...

  16. 48 CFR 252.247-7022 - Representation of extent of transportation by sea.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of transportation by sea. 252.247-7022 Section 252.247-7022 Federal Acquisition Regulations System... transportation by sea. As prescribed in 247.574(a), use the following provision: Representation of Extent of Transportation By Sea (AUG 1992) (a) The Offeror shall indicate by checking the appropriate blank in paragraph (b...

  17. 48 CFR 52.247-58 - Loading, Blocking, and Bracing of Freight Car Shipments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Bracing of Freight Car Shipments. 52.247-58 Section 52.247-58 Federal Acquisition Regulations System... Text of Provisions and Clauses 52.247-58 Loading, Blocking, and Bracing of Freight Car Shipments. As... be shipped in carload lots by rail: Loading, Blocking, and Bracing of Freight Car Shipments (APR 1984...

  18. 48 CFR 52.247-58 - Loading, Blocking, and Bracing of Freight Car Shipments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Bracing of Freight Car Shipments. 52.247-58 Section 52.247-58 Federal Acquisition Regulations System... Text of Provisions and Clauses 52.247-58 Loading, Blocking, and Bracing of Freight Car Shipments. As... be shipped in carload lots by rail: Loading, Blocking, and Bracing of Freight Car Shipments (APR 1984...

  19. 48 CFR 52.247-58 - Loading, Blocking, and Bracing of Freight Car Shipments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Bracing of Freight Car Shipments. 52.247-58 Section 52.247-58 Federal Acquisition Regulations System... Text of Provisions and Clauses 52.247-58 Loading, Blocking, and Bracing of Freight Car Shipments. As... be shipped in carload lots by rail: Loading, Blocking, and Bracing of Freight Car Shipments (APR 1984...

  20. 48 CFR 52.247-58 - Loading, Blocking, and Bracing of Freight Car Shipments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Bracing of Freight Car Shipments. 52.247-58 Section 52.247-58 Federal Acquisition Regulations System... Text of Provisions and Clauses 52.247-58 Loading, Blocking, and Bracing of Freight Car Shipments. As... be shipped in carload lots by rail: Loading, Blocking, and Bracing of Freight Car Shipments (APR 1984...

  1. 48 CFR 52.247-58 - Loading, Blocking, and Bracing of Freight Car Shipments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... be shipped in carload lots by rail: Loading, Blocking, and Bracing of Freight Car Shipments (APR 1984... Bracing of Freight Car Shipments. 52.247-58 Section 52.247-58 Federal Acquisition Regulations System... Text of Provisions and Clauses 52.247-58 Loading, Blocking, and Bracing of Freight Car Shipments. As...

  2. 17 CFR 247.741 - Exemption for banks effecting transactions in money market funds.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... transactions in money market funds. 247.741 Section 247.741 Commodity and Securities Exchanges SECURITIES AND... FROM THE DEFINITION OF BROKER § 247.741 Exemption for banks effecting transactions in money market... issued by a money market fund, provided that: (1) The bank either (i) Provides the customer, directly or...

  3. 17 CFR 247.741 - Exemption for banks effecting transactions in money market funds.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... transactions in money market funds. 247.741 Section 247.741 Commodity and Securities Exchanges SECURITIES AND... FROM THE DEFINITION OF BROKER § 247.741 Exemption for banks effecting transactions in money market... issued by a money market fund, provided that: (1) The bank either (i) Provides the customer, directly or...

  4. 48 CFR 52.247-67 - Submission of Transportation Documents for Audit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Submission of Transportation Documents for Audit. 52.247-67 Section 52.247-67 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.247-67 Submission...

  5. 47 CFR 90.247 - Mobile repeater stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Mobile repeater stations. 90.247 Section 90.247... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.247 Mobile repeater stations. A mobile station authorized to operate on a mobile service frequency above 25 MHz may be used as a mobile...

  6. 47 CFR 90.247 - Mobile repeater stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Mobile repeater stations. 90.247 Section 90.247... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.247 Mobile repeater stations. A mobile station authorized to operate on a mobile service frequency above 25 MHz may be used as a mobile...

  7. 47 CFR 90.247 - Mobile repeater stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Mobile repeater stations. 90.247 Section 90.247... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.247 Mobile repeater stations. A mobile station authorized to operate on a mobile service frequency above 25 MHz may be used as a mobile...

  8. 47 CFR 90.247 - Mobile repeater stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Mobile repeater stations. 90.247 Section 90.247... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.247 Mobile repeater stations. A mobile station authorized to operate on a mobile service frequency above 25 MHz may be used as a mobile...

  9. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

  10. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

  11. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

  12. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

  13. 25 CFR 247.7 - Can I build a structure?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I build a structure? 247.7 Section 247.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.7 Can I build a structure? (a) You may not build any structures at the sites...

  14. 43 CFR 2.47 - Records subject to Privacy Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

  15. 43 CFR 2.47 - Records subject to Privacy Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

  16. 43 CFR 2.47 - Records subject to Privacy Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

  17. 48 CFR 52.247-11 - Net Weight-Household Goods or Office Furniture.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Net Weight-Household Goods or Office Furniture. 52.247-11 Section 52.247-11 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.247-11 Net...

  18. 78 FR 73824 - Subzones 247A and 247B, Authorization of Production Activity, GE Transportation, (Locomotives...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-76-2013] Subzones 247A and 247B, Authorization of Production Activity, GE Transportation, (Locomotives, Off-Highway Vehicles and Motors/Engines), Lawrence Park and Grove City, Pennsylvania On July 18, 2013, GE Transportation submitted a notification of proposed production activity to the Foreig...

  19. 25 CFR 247.16 - What fire is permitted?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What fire is permitted? 247.16 Section 247.16 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.16 What fire is permitted? (a) You may have a fire in designated fire places...

  20. 25 CFR 247.16 - What fire is permitted?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What fire is permitted? 247.16 Section 247.16 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.16 What fire is permitted? (a) You may have a fire in designated fire places...

  1. 49 CFR 234.247 - Purpose of inspections and tests; removal from service of relay or device failing to meet test...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... operations over the grade crossing resume. (c) Any electronic device, relay, or other electromagnetic device... service of relay or device failing to meet test requirements. 234.247 Section 234.247 Transportation Other... Inspections and Tests § 234.247 Purpose of inspections and tests; removal from service of relay or device...

  2. 32 CFR Appendix B to Part 247 - CE Publications

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in addition to that required in § 247.4 (i) and (j). “The editorial content of this publication is... avoid conflicts of interest. 3 See footnote 1 to section G.3. of this appendix. J. Contracting for a CE... advertisers of the requirements in § 247.4(i) and § 247.4(j). d. A provision substantially as follows: “The...

  3. 48 CFR 52.247-46 - Shipping Point(s) Used in Evaluation of F.o.b. Origin Offers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Evaluation of F.o.b. Origin Offers. 52.247-46 Section 52.247-46 Federal Acquisition Regulations System... Text of Provisions and Clauses 52.247-46 Shipping Point(s) Used in Evaluation of F.o.b. Origin Offers. As prescribed in 47.305-3(b)(4)(ii), insert the following provision in f.o.b. origin solicitations...

  4. 32 CFR Appendix C to Part 247 - Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and Distribution of...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., and Installation Maps; Sales and Distribution of Non-DoD Publications C Appendix C to Part 247...) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. C Appendix C to Part 247—Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and...

  5. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.

    PubMed

    Hewitt, Ellen; Pitcher, Thomas; Rizoska, Biljana; Tunblad, Karin; Henderson, Ian; Sahlberg, Britt-Louise; Grabowska, Urszula; Classon, Björn; Edenius, Charlotte; Malcangio, Marzia; Lindström, Erik

    2016-09-01

    Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models. The current study evaluated the effects when combining the selective cathepsin S inhibitor MIV-247 with gabapentin or pregabalin in a mouse model of neuropathic pain. Mice were rendered neuropathic by partial sciatic nerve ligation. MIV-247, gabapentin, or pregabalin were administered alone or in combination via oral gavage. Mechanical allodynia was assessed using von Frey hairs. Neurobehavioral side effects were evaluated by assessing beam walking. MIV-247, gabapentin, and pregabalin concentrations in various tissues were measured. Oral administration of MIV-247 (100-200 µmol/kg) dose-dependently attenuated mechanical allodynia by up to approximately 50% reversal when given as a single dose or when given twice daily for 5 days. No behavioral deficits were observed at any dose of MIV-247 tested. Gabapentin (58-350 µmol/kg) and pregabalin (63-377 µmol/kg) also inhibited mechanical allodynia with virtually complete reversal at the highest doses tested. The minimum effective dose of MIV-247 (100 µmol/kg) in combination with the minimum effective dose of pregabalin (75 µmol/kg) or gabapentin (146 µmol/kg) resulted in enhanced antiallodynic efficacy without augmenting side effects. A subeffective dose of MIV-247 (50 µmol/kg) in combination with a subeffective dose of pregabalin (38 µmol/kg) or gabapentin (73 µmol/kg) also resulted in substantial efficacy. Plasma levels of MIV-247, gabapentin, and pregabalin were similar when given in combination as to when given alone. Cathepsin S inhibition with MIV-247 exerts significant antiallodynic efficacy alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects or inducing pharmacokinetic interactions. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  6. Effect of Preheating on the Inertia Friction Welding of the Dissimilar Superalloys Mar-M247 and LSHR

    NASA Astrophysics Data System (ADS)

    Senkov, O. N.; Mahaffey, D. W.; Semiatin, S. L.

    2016-12-01

    Differences in the elevated temperature mechanical properties of cast Mar-M247 and forged LSHR make it difficult to produce sound joints of these alloys by inertia friction welding (IFW). While extensive plastic upset occurs on the LSHR side, only a small upset is typically developed on the Mar-M247 side. The limited plastic flow of Mar-M247 thus restricts the extent of "self-cleaning" and mechanical mixing of the mating surfaces, so that defects remain at the bond line after welding. In the present work, the effect of local preheating of Mar-M247 immediately prior to IFW on the welding behavior of Mar-M247/LSHR couples was determined. An increase in the preheat temperature enhanced the plastic flow of Mar-M247 during IFW, which resulted in extensive mechanical mixing with LSHR at the weld interface, the formation of extensive flash on both the Mar-M247 and LSHR sides, and a sound bond. Performed in parallel with the experimental work, finite-element-method (FEM) simulations showed that higher temperatures are achieved within the preheated sample during IFW relative to its non-preheated counterpart, and plastic flow is thus facilitated within it. Microstructure and post-weld mechanical properties of the welded samples were also established.

  7. 7 CFR 247.24 - Recovery and redistribution of caseload and administrative funds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL... of §§ 247.21(a) and 247.22(b). In reassigning caseload, FNS will use the most up-to-date data on...

  8. 40 CFR 247.13 - Transportation products.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Transportation products. 247.13 Section 247.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Transportation products. (a) Traffic barricades and traffic cones used in controlling or restricting vehicular...

  9. 40 CFR 247.13 - Transportation products.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Transportation products. 247.13 Section 247.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Transportation products. (a) Traffic barricades and traffic cones used in controlling or restricting vehicular...

  10. 40 CFR 247.13 - Transportation products.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Transportation products. 247.13 Section 247.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Transportation products. (a) Traffic barricades and traffic cones used in controlling or restricting vehicular...

  11. 40 CFR 247.13 - Transportation products.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Transportation products. 247.13 Section 247.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Transportation products. (a) Traffic barricades and traffic cones used in controlling or restricting vehicular...

  12. 40 CFR 247.13 - Transportation products.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Transportation products. 247.13... COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.13 Transportation products. (a) Traffic barricades and traffic cones used in controlling or restricting vehicular...

  13. 40 CFR 247.11 - Vehicular products.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Vehicular products. 247.11 Section 247.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE... fluids, and gear oils, excluding marine and aviation oils. (b) Tires, excluding airplane tires. (c...

  14. 40 CFR 247.11 - Vehicular products.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Vehicular products. 247.11 Section 247.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES COMPREHENSIVE... fluids, and gear oils, excluding marine and aviation oils. (b) Tires, excluding airplane tires. (c...

  15. 48 CFR 247.301-71 - Evaluation factor or subfactor.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Evaluation factor or subfactor. 247.301-71 Section 247.301-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply...

  16. 48 CFR 247.301-71 - Evaluation factor or subfactor.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Evaluation factor or subfactor. 247.301-71 Section 247.301-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply...

  17. 48 CFR 247.301-71 - Evaluation factor or subfactor.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Evaluation factor or subfactor. 247.301-71 Section 247.301-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply...

  18. 48 CFR 247.301-71 - Evaluation factor or subfactor.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Evaluation factor or subfactor. 247.301-71 Section 247.301-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply...

  19. 48 CFR 247.301-71 - Evaluation factor or subfactor.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Evaluation factor or subfactor. 247.301-71 Section 247.301-71 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply...

  20. 48 CFR 252.247-7008 - Evaluation of bids.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ....247-7008 Section 252.247-7008 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of... the administrative costs in paragraph (b)(1). (c) When drayage is necessary for the accomplishment of...

  1. 7 CFR 247.8 - Individuals applying to participate in CSFP.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

  2. 7 CFR 247.8 - Individuals applying to participate in CSFP.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

  3. 7 CFR 247.8 - Individuals applying to participate in CSFP.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

  4. 7 CFR 247.8 - Individuals applying to participate in CSFP.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 247.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8... by the Office of Management and Budget under control number 0584-0293) ...

  5. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Becker, Stephen Allan

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowsharemore » Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.« less

  6. 7 CFR 247.36 - Confidentiality of applicants or participants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 247.36 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.36... with other health or welfare programs for the purpose of preventing dual participation. In addition...

  7. 7 CFR 247.36 - Confidentiality of applicants or participants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 247.36 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.36... with other health or welfare programs for the purpose of preventing dual participation. In addition...

  8. 7 CFR 247.5 - State and local agency responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Providing nutrition education and information on the availability of other nutrition and health assistance... 247.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.5 State and...

  9. 7 CFR 247.5 - State and local agency responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Providing nutrition education and information on the availability of other nutrition and health assistance... 247.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.5 State and...

  10. 7 CFR 247.36 - Confidentiality of applicants or participants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 247.36 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.36... with other health or welfare programs for the purpose of preventing dual participation. In addition...

  11. 7 CFR 247.5 - State and local agency responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Providing nutrition education and information on the availability of other nutrition and health assistance... 247.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.5 State and...

  12. 7 CFR 247.36 - Confidentiality of applicants or participants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 247.36 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.36... with other health or welfare programs for the purpose of preventing dual participation. In addition...

  13. 7 CFR 247.36 - Confidentiality of applicants or participants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 247.36 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.36... with other health or welfare programs for the purpose of preventing dual participation. In addition...

  14. 48 CFR 252.247-7007 - Liability and insurance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... 252.247-7007 Section 252.247-7007 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text... of the Contracting Officer, be a self-insurer against the risk of this paragraph (d)(1). (ii) This...

  15. 24 CFR 247.4 - Termination notice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Termination notice. 247.4 Section 247.4 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  16. 24 CFR 247.4 - Termination notice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Termination notice. 247.4 Section 247.4 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  17. 7 CFR 247.32 - Termination of agency participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 247.32 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.32 Termination... the reasons for the action, and the effective date. (2) Termination by State agency. The State agency...

  18. 7 CFR 247.32 - Termination of agency participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 247.32 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.32 Termination... the reasons for the action, and the effective date. (2) Termination by State agency. The State agency...

  19. 7 CFR 247.30 - Claims.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.30 Claims. (a) What happens if a... accordance with § 247.29. (Approved by the Office of Management and Budget under control number 0584-0293) ...

  20. 7 CFR 247.30 - Claims.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.30 Claims. (a) What happens if a... accordance with § 247.29. (Approved by the Office of Management and Budget under control number 0584-0293) ...

  1. 7 CFR 247.30 - Claims.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.30 Claims. (a) What happens if a... accordance with § 247.29. (Approved by the Office of Management and Budget under control number 0584-0293) ...

  2. 7 CFR 247.19 - Dual participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.19 Dual participation. (a) What must... with § 247.30(c). (Approved by the Office of Management and Budget under control number 0584-0293) ...

  3. 7 CFR 247.19 - Dual participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.19 Dual participation. (a) What must... with § 247.30(c). (Approved by the Office of Management and Budget under control number 0584-0293) ...

  4. 7 CFR 247.30 - Claims.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.30 Claims. (a) What happens if a... accordance with § 247.29. (Approved by the Office of Management and Budget under control number 0584-0293) ...

  5. 7 CFR 247.19 - Dual participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.19 Dual participation. (a) What must... with § 247.30(c). (Approved by the Office of Management and Budget under control number 0584-0293) ...

  6. 7 CFR 247.30 - Claims.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.30 Claims. (a) What happens if a... accordance with § 247.29. (Approved by the Office of Management and Budget under control number 0584-0293) ...

  7. 7 CFR 247.19 - Dual participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.19 Dual participation. (a) What must... with § 247.30(c). (Approved by the Office of Management and Budget under control number 0584-0293) ...

  8. 40 CFR 247.10 - Paper and paper products.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Paper and paper products. 247.10... COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.10 Paper and paper products. Paper and paper products, excluding building and construction paper grades. ...

  9. 40 CFR 247.10 - Paper and paper products.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Paper and paper products. 247.10... COMPREHENSIVE PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.10 Paper and paper products. Paper and paper products, excluding building and construction paper grades. ...

  10. 48 CFR 247.371 - DD Form 1653, Transportation Data for Solicitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1653, Transportation Data for Solicitations. 247.371 Section 247.371 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in...

  11. 48 CFR 3452.247-70 - Foreign travel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Foreign travel. 3452.247-70 Section 3452.247-70 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION... travel” means travel outside the fifty States comprising the United States, the District of Columbia, and...

  12. Cellular immune response to β2-glycoprotein-I valine/leucine247 phenotypes in Mexican patients with primary antiphospholipid syndrome.

    PubMed

    Núñez-Álvarez, Carlos A; Hernández-Ramírez, Diego F; Martinez-Castillo, Araceli; Pascual Ramos, Virginia; Cabiedes, Javier; Ortega, Alicia; Cabral, Antonio R

    2017-02-01

    Homozygote genotype V 247 of the β 2 -glycoprotein-I (β 2 GP-I) gene has been associated with anti-β 2 GP-I and thrombosis in patients with primary anti-phospholipid syndrome APS (PAPS). However, the cellular immune response to β 2 GP-I 247 has been little studied. To evaluate the immune cellular proliferation in response to native and non-native β 2 GP-I 247 valine/leucine phenotype from Mexican patients with PAPS. We studied 10 patients with PAPS and 10 healthy control subjects (HC). The polymorphism at position 247 of the β 2 GP-I gene was determined by PCR-RFLP and the corresponding β 2 GP-I protein was subsequently purified from normal human plasma by affinity chromatography. PBMC purified from patients and controls were stimulated with β 2 GP-I under native and in non native (reduced) conditions. We also determined the anti-β 2 GP-I production in vitro by B cell clones (EBV) generated in cocultures experiments. Differential Scanning Calorimetry (DSC) was studied to determine the structural differences between the β 2 GP-I 247 valine/leucine isoforms. Cytokine profile (IL-2, IL-4, IL-6, TNFα, INFγ) was evaluated in culture supernatants. PAPS and healthy control PBMCs had a higher proliferative response when stimulated with β 2 GP-I under reduced cultures conditions compared to non-denatured conditions. PBMCs response from PAPS patients was higher. We observed more cell proliferation in response to β 2 GP-I 247 valine/leucine or valine isoforms in non-native conditions. In contrast, this response was not significant against β 2 GP-I 247 leucine. These findings were T CD4 + -dependent. Similar results were obtained with B cell clones derived from PAPS patients, which showed more pronounced proliferation in non native conditions and higher against β 2 GP-I 247 valine. No differences were found in anti-β 2 GP-I production, but high levels of IL-6 in vitro were identified. The structural analysis of both β 2 GP-I 247 isoforms by DSC showed a major conformational change due to a single mutation in the β 2 GP-I variants. PAPS PBMCs had a higher cellular response against β 2 GP-I 247 in non-native culture conditions preferentially to the β 2 GP-I 247 valine phenotype. This effect is T CD4 + dependent and appears to be driven by tertiary structural changes adopted by β 2 GP-I 247 polymorphism. Copyright © 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

  13. 48 CFR 247.573-3 - Annual reporting requirement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirement. 247.573-3 Section 247.573-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag... report to the congressional defense committees, by June 1st of each year, in accordance with Section 1017...

  14. 48 CFR 247.573-3 - Annual reporting requirement.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirement. 247.573-3 Section 247.573-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag... report to the congressional defense committees, by June 1st of each year, in accordance with Section 1017...

  15. 7 CFR 247.17 - Notification of discontinuance of participant.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 247.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.17... effective date of discontinuance. (b) What must a local agency do if it has to discontinue a participant...

  16. 7 CFR 247.17 - Notification of discontinuance of participant.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 247.17 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.17... effective date of discontinuance. (b) What must a local agency do if it has to discontinue a participant...

  17. 48 CFR 52.247-60 - Guaranteed Shipping Characteristics.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Guaranteed Shipping Characteristics. 52.247-60 Section 52.247-60 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... information will be used to determine transportation costs for evaluation purposes. If the offeror does not...

  18. 48 CFR 52.247-60 - Guaranteed Shipping Characteristics.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Guaranteed Shipping Characteristics. 52.247-60 Section 52.247-60 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... information will be used to determine transportation costs for evaluation purposes. If the offeror does not...

  19. 48 CFR 252.247-7008 - Evaluation of bids.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....247-7008 Section 252.247-7008 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of... accomplishment of any item in the bid schedule, the Offeror shall include in the unit price any costs for bridge...

  20. 32 CFR 247.6 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Procedures. 247.6 Section 247.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF... the missions of the Department of Defense. (4) DoD editors of publications covered under this part...

  1. 32 CFR 247.6 - Procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Procedures. 247.6 Section 247.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF... the missions of the Department of Defense. (4) DoD editors of publications covered under this part...

  2. 32 CFR 247.6 - Procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Procedures. 247.6 Section 247.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF... the missions of the Department of Defense. (4) DoD editors of publications covered under this part...

  3. 48 CFR 252.247-7008 - Evaluation of bids.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....247-7008 Section 252.247-7008 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of... accomplishment of any item in the bid schedule, the Offeror shall include in the unit price any costs for bridge...

  4. 48 CFR 252.247-7008 - Evaluation of bids.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ....247-7008 Section 252.247-7008 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of... accomplishment of any item in the bid schedule, the Offeror shall include in the unit price any costs for bridge...

  5. 32 CFR 247.6 - Procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Procedures. 247.6 Section 247.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF... the missions of the Department of Defense. (4) DoD editors of publications covered under this part...

  6. 32 CFR 247.6 - Procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Procedures. 247.6 Section 247.6 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF... the missions of the Department of Defense. (4) DoD editors of publications covered under this part...

  7. 48 CFR 252.247-7008 - Evaluation of bids.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ....247-7008 Section 252.247-7008 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of... accomplishment of any item in the bid schedule, the Offeror shall include in the unit price any costs for bridge...

  8. 48 CFR 452.247-70 - Delivery Location.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Delivery Location. 452.247-70 Section 452.247-70 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CLAUSES AND... Location. As prescribed in 447.302, insert a clause substantially as follows: Delivery Location (FEB 1988...

  9. 48 CFR 247.270-2 - Technical provisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Technical provisions. 247...-Related Services 247.270-2 Technical provisions. (a) Because conditions vary at different ports, and sometimes within the same port, it is not practical to develop standard technical provisions covering all...

  10. 49 CFR 24.7 - Federal Agency waiver of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Federal Agency waiver of regulations. 24.7 Section 24.7 Transportation Office of the Secretary of Transportation UNIFORM RELOCATION ASSISTANCE AND REAL... regulations. The Federal Agency funding the project may waive any requirement in this part not required by law...

  11. 46 CFR 169.247 - Firefighting equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... certification and periodic inspection and at such other times as considered necessary all fire-extinguishing... condition of the equipment. The inspector verifies that the tests and inspections required in Tables 169.247.... Table 169.247(a)(1)—Portable Extinguishers Type unit Test Foam Discharge. Clean hose and inside of...

  12. 46 CFR 169.247 - Firefighting equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... certification and periodic inspection and at such other times as considered necessary all fire-extinguishing... condition of the equipment. The inspector verifies that the tests and inspections required in Tables 169.247.... Table 169.247(a)(1)—Portable Extinguishers Type unit Test Foam Discharge. Clean hose and inside of...

  13. 30 CFR 550.247 - What biological, physical, and socioeconomic information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... information must accompany the DPP or DOCD? 550.247 Section 550.247 Mineral Resources BUREAU OF OCEAN ENERGY... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the MMPA, sensitive underwater features, marine sanctuaries, critical habitat designated...

  14. 30 CFR 550.247 - What biological, physical, and socioeconomic information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... information must accompany the DPP or DOCD? 550.247 Section 550.247 Mineral Resources BUREAU OF OCEAN ENERGY... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the MMPA, sensitive underwater features, marine sanctuaries, critical habitat designated...

  15. 30 CFR 550.247 - What biological, physical, and socioeconomic information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... information must accompany the DPP or DOCD? 550.247 Section 550.247 Mineral Resources BUREAU OF OCEAN ENERGY... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the MMPA, sensitive underwater features, marine sanctuaries, critical habitat designated...

  16. 40 CFR 52.247 - Control Strategy and regulations: Fine Particle Matter.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false Control Strategy and regulations: Fine Particle Matter. 52.247 Section 52.247 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Strategy and regulations: Fine Particle Matter. (a) Determination of Attainment: Effective February 8, 2013...

  17. 40 CFR 52.247 - Control Strategy and regulations: Fine Particle Matter.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false Control Strategy and regulations: Fine Particle Matter. 52.247 Section 52.247 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Strategy and regulations: Fine Particle Matter. (a) Determination of Attainment: Effective February 8, 2013...

  18. 27 CFR 19.247 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false General. 19.247 Section 19.247 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... discretion of the appropriate TTB officer, be required in any other contingency affecting the validity or...

  19. Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations

    NASA Astrophysics Data System (ADS)

    Tsukamoto, Shuichiro; Sakae, Yoshitake; Itoh, Yukihiro; Suzuki, Takayoshi; Okamoto, Yuko

    2018-03-01

    We performed protein-ligand docking simulations with a ligand T247, which has been reported as a selective inhibitor of a histone deacetylase HDAC3, by the replica-exchange umbrella sampling method in order to estimate the free energy profiles along ligand docking pathways of HDAC3-T247 and HDAC2-T247 systems. The simulation results showed that the docked state of the HDAC3-T247 system is more stable than that of the HDAC2-T247 system although the amino-acid sequences and structures of HDAC3 and HDAC2 are very similar. By comparing structures obtained from the simulations of both systems, we found the difference between structures of hydrophobic residues at the entrance of the catalytic site. Moreover, we performed conventional molecular dynamics simulations of HDAC3 and HDAC2 systems without T247, and the results also showed the same difference of the hydrophobic structures. Therefore, we consider that this hydrophobic structure contributes to the stabilization of the docked state of the HDAC3-T247 system. Furthermore, we show that Tyr209, which is one of the hydrophobic residues in HDAC2, plays a key role in the instability from the simulation results of a mutated-HDAC2 system.

  20. ISA 247: trans-ISA 247, trans-R 1524, ISA(TX)247, ISAtx 247, ISATx247, LX 211, LX211, R 1524, R-1524.

    PubMed

    2007-01-01

    Isotechnika is developing the immunosuppressive drug ISA 247, a calcineurin inhibitor that is undergoing clinical development for the treatment of psoriasis (phase III) and prevention of organ rejection after transplantation (phase II). Preclinical development for uveitis is also underway. Other autoimmune disease indications that could be explored include arthritis, type I diabetes and Crohn's disease. ISA 247 was being co-developed as R 1524 by Isotechnika and Roche. However, Roche is no longer involved in the development of this compound. Based on analysis of previously collected data, the trans-ISA 247 isomer was found to be more bioavailable and it is expected that this isomer can be administered at a lower dose compared with the previous formulation that consisted of an equivalent mixture of the two geometric isomers (cis and trans). Preclinical observations indicate that ISA 247 has the potential to be more potent and less toxic than other marketed immunosuppressants in its class used for the prevention of transplant rejection. Experiments to date suggest that ISA 247 is about three times as potent as ciclosporin, while genotoxicity studies in animals have shown that the compound has a significantly reduced tendency to cause renal toxicity. The combination of reduced toxicity and improved potency would give ISA 247 a therapeutic benefit over existing calcineurin-based treatments. Isotechnika and Roche entered into a co-development and commercialisation agreement in April 2002, with Roche gaining the exclusive worldwide marketing rights for ISA 247; Isotechnika received milestone payments of $US4 million and $CAN21.9 million in September 2002 and May 2003, respectively. The agreement was restructured in April 2004, under which Isotechnika will now solely manage and fund the clinical development of trans-ISA 247. Upon successful completion of these trials, Isotechnika will conduct at its own expense a phase IIb study in renal transplantation and phase III studies in psoriasis. Roche will have the right to opt-in to the development and commercialisation of trans-ISA 247 for transplant indications up to the end of the phase IIb renal transplantation trial. Isotechnika retains all rights to develop and commercialise the product outside of transplant indications. Under an agreement signed with Cellgate Inc. on 25 April 2006, Isotechnika has the option to obtain an exclusive licence to develop and commercialise conjugates consisting of Cellgate's patented transporter technology, for the topical delivery of ISA 247 in patients with mild-to-moderate psoriasis. Cellgate will perform studies to evaluate the feasibility of using their technology to topically deliver ISA 247. In return, Isotechnika will pay Cellgate Inc. a total of $US500 000, with $US100 000 paid upfront, and the remainder at predetermined time points. Upon successful completion of the studies, Isotechnika has the option to further develop and commercialise conjugates for topical delivery of ISA 247. Isotechnika and Atrium Medical Corporation announced an exclusive worldwide licensing agreement for ISA 247 alone and in combination with TAFA 93 with respect to drug-eluting devices, in September 2005. Atrium's implantable products include those for the local, non-systemic treatment of vascular and cardiovascular disorders, soft tissue repair and other disorders. In May 2006, Isotechnika licensed ISA 247 to Lux Biosciences for ophthalmic indications. Under terms of the agreement, Lux Biosciences obtains the exclusive worldwide marketing rights to ISA 247 for treatment and prophylaxis of all ophthalmic indications. The company will be responsible for development, registration and marketing of the drug for ophthalmic indications and will make upfront and milestone payments to Isotechnika in addition to royalties on any sales. Isotechnika formalised a manufacturing agreement with Swiss-based Lonza Ltd in June 2004. Under the terms of the agreement, Lonza will manufacture sufficient quantities of trans-ISA 247 in a GMP environment for use in the company's upcoming clinical trials. Isotechnika completed the phase III SPIRIT trial of ISA 247 for psoriasis in Canada. The randomised, double-blind trial compared the efficacy of three doses of ISA 247 (0.2 mg/kg [low dose], 0.3 mg/kg [mid dose] and 0.4 mg/kg [high dose] twice daily) with placebo, with equal numbers of patients assigned to each of the four groups. Subsequent to the first 12 weeks, those patients who received placebo moved into the mid-dose group for the remaining 12 weeks of the study. Patients already receiving ISA 247 remained in their respective dosing groups for the final 12 weeks of the trial. Patients completing the 24-week SPIRIT trial were given the opportunity to continue therapy for an addditonal 36 weeks or to discontinue therapy. Those patients who chose to enrol in the extension trial were moved from the 0.2 mg/kg bid (low-dose) or 0.4 mg/kg bid (high-dose) groups into the the 0.3 bid mg/kg bid (mid dose) group. Patients who commenced the SPIRIT trial in the mid-dose group remained on the same dosage regimen for the duration of the extension trial. The goal of the extension trial is to demonstrate continued therapeutic benefit to psoriasis patients while gathering long-term safety data. So far, data has been received on 193 patients receiving treatment for a total of 48 weeks. A phase IIa trial investigating the safety and efficacy of ISA 247 in renal transplantation was completed in the US and Canada in January 2003. The trial compared ISA 247 with ciclosporin (Neoral in approximately 130 stable renal transplant patients who underwent transplantation at least 6 months prior to enrolment; patient recruitment was completed in October 2002. Half of the patients were treated with ciclosporin and the other half received ISA 247 over a 90-day period. An extension trial was then initiated in which another 200 patients were treated with ISA 247 for up to 6 months from the time of transplantation. Results from the trial were reported. All endpoints were achieved in a multiple ascending dose study of trans-ISA 247 in November 2004. The study, initiated in June 2004, was conducted by SFBC Anapharm in Montreal, Canada and involved 43 healthy volunteers. Final dosing recommendations are to be determined in phase III trials in patients with psoriasis. Interim results reported in September 2004, of a double-blind, parallel-group, placebo and moxifloxacin controlled, randomised single-dose QTc trial in healthy volunteers, showed no evidence of QTc prolongation when trans-ISA 247 was administered at therapeutic doses. A single ascending dose (SAD) trial for trans-ISA 247 was completed in July 2004. The SAD trial was conducted among healthy volunteers to assess the appropriate dosage of trans-ISA 247 for further clinical evaluations. The trial commenced in March 2004 with approximately 46 subjects enrolled under the supervision of MDS Pharma Services in Phoenix, Arizona, USA. Isotechnika received US FDA approval for the SAD trial in February 2004. A European patent (No. EP 0 991 660) entitled 'Deuterated and Undeuterated Cyclosporine Analgoues and Their Use as Immunomodulating Agents' was issued to Isotechnika for ISA 247, in October 2006. A US patent entitled 'Novel Cyclosporin Analogue Formulations' was issued to Isotechnika (No. 7 060 672) for ISA 247 in June 2006. The patent claims have been filed in 36 countries, and in the US it is the first patent to be issued in this patent family. Isotechnika was issued a US patent (No. 6 998 385, entitled 'Cyclosporine Analogue Mixtures and their use as Immunomodulating Agents') in February 2006 covering mixtures of cis- and trans- isomers of ISA 257. This patent is the first US patent to be issued in this family of patents. These patent claims have been filed in 36 countries. Three patents relating to this claim were previously issued in the following countries; Morocco (No. 26337 issued 1 October 2004); Pakistan (No. 138338 issued 30 September 2004) and South Africa (No. 2004/2270 issued 25 May 2005). A US patent (No 6 686 454) was issued in February 2004 entitled 'Antibodies to Specific Regions of Cyclosporine Related Compounds'. This patent covers a novel, simple and cost-effective assay used in the use and management of ISA 247. It also received another US patent entitled 'Deuterated Cyclosporine Analogs and their Use as Immunomodulating Agents'. Isotechnika has received patents for chemical composition of ISA 247 in New Zealand (November 2001; New Zealand Patent No. 502362), Canada (December 2001; Canadian Patent No. 2 298 572), South Korea (June 2006; South Korean Patent No. 585348) and Australia (November 2002; Australian Patent No. 750245). In addition, Isotechnika announced in August 2003 that it had been granted US patent No. 6 605 593, entitled 'Deuterated Ciclosporine Analogs and their use as Immunomodulating Agents'. An additional US patent covering ISA 247 was granted in September 2003.

  1. 5 CFR 532.247 - Wage change surveys.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Wage change surveys. 532.247 Section 532... SYSTEMS Prevailing Rate Determinations § 532.247 Wage change surveys. (a) Wage change surveys shall be conducted in each wage area in years during which full-scale wage surveys are not conducted. (b) Data shall...

  2. 5 CFR 532.247 - Wage change surveys.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Wage change surveys. 532.247 Section 532... SYSTEMS Prevailing Rate Determinations § 532.247 Wage change surveys. (a) Wage change surveys shall be conducted in each wage area in years during which full-scale wage surveys are not conducted. (b) Data shall...

  3. 5 CFR 532.247 - Wage change surveys.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Wage change surveys. 532.247 Section 532... SYSTEMS Prevailing Rate Determinations § 532.247 Wage change surveys. (a) Wage change surveys shall be conducted in each wage area in years during which full-scale wage surveys are not conducted. (b) Data shall...

  4. 5 CFR 532.247 - Wage change surveys.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Wage change surveys. 532.247 Section 532... SYSTEMS Prevailing Rate Determinations § 532.247 Wage change surveys. (a) Wage change surveys shall be conducted in each wage area in years during which full-scale wage surveys are not conducted. (b) Data shall...

  5. 7 CFR 58.247 - Insect and rodent control program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Insect and rodent control program. 58.247 Section 58... Service 1 Operations and Operating Procedures § 58.247 Insect and rodent control program. In addition to... made responsible for the performance of a regularly scheduled insect and rodent control program as...

  6. 50 CFR 665.247 - At-sea observer coverage.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

  7. 50 CFR 665.247 - At-sea observer coverage.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

  8. 50 CFR 665.247 - At-sea observer coverage.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

  9. 50 CFR 665.247 - At-sea observer coverage.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

  10. 50 CFR 665.247 - At-sea observer coverage.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.247 Section 665.247 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...-sea observer coverage. All fishing vessels subject to §§ 665.240 though 665.252 and subpart A of this...

  11. 30 CFR 250.247 - What biological, physical, and socioeconomic information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What biological, physical, and socioeconomic information must accompany the DPP or DOCD? 250.247 Section 250.247 Mineral Resources BUREAU OF OCEAN ENERGY... species, marine mammals protected under the MMPA, sensitive underwater features, marine sanctuaries...

  12. 48 CFR 252.247-7002 - Revision of prices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Revision of prices. 252... Provisions And Clauses 252.247-7002 Revision of prices. As prescribed in 247.270-4(c), use the following clause: Revision of Prices (DEC 1991) (a) Definition. Wage adjustment, as used in this clause, means a...

  13. 48 CFR 952.247-70 - Foreign travel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., Official Foreign Travel, or its successor in effect at the time of award. (End of clause) [65 FR 81009, Dec... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Foreign travel. 952.247-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.247-70 Foreign travel. As...

  14. 48 CFR 952.247-70 - Foreign travel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., Official Foreign Travel, or its successor in effect at the time of award. (End of clause) [65 FR 81009, Dec... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Foreign travel. 952.247-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.247-70 Foreign travel. As...

  15. 48 CFR 952.247-70 - Foreign travel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., Official Foreign Travel, or its successor in effect at the time of award. (End of clause) [65 FR 81009, Dec... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Foreign travel. 952.247-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.247-70 Foreign travel. As...

  16. 48 CFR 952.247-70 - Foreign travel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., Official Foreign Travel, or its successor in effect at the time of award. (End of clause) [65 FR 81009, Dec... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Foreign travel. 952.247-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.247-70 Foreign travel. As...

  17. 48 CFR 952.247-70 - Foreign travel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., Official Foreign Travel, or its successor in effect at the time of award. (End of clause) [65 FR 81009, Dec... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Foreign travel. 952.247-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.247-70 Foreign travel. As...

  18. 7 CFR 247.11 - Applicants exceed caseload levels.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Applicants exceed caseload levels. 247.11 Section 247... exceed caseload levels. (a) What must the local agency do if the number of applicants exceeds the local agency's caseload level? If all caseload has been filled, the local agency must maintain a waiting list...

  19. 30 CFR 250.247 - What biological, physical, and socioeconomic information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What biological, physical, and socioeconomic information must accompany the DPP or DOCD? 250.247 Section 250.247 Mineral Resources MINERALS MANAGEMENT... SHELF Plans and Information Contents of Development and Production Plans (dpp) and Development...

  20. 7 CFR 58.247 - Insect and rodent control program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Insect and rodent control program. 58.247 Section 58... Service 1 Operations and Operating Procedures § 58.247 Insect and rodent control program. In addition to... made responsible for the performance of a regularly scheduled insect and rodent control program as...

  1. 25 CFR 247.20 - What are the road and trail prohibitions?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What are the road and trail prohibitions? 247.20 Section... RIVER TREATY FISHING ACCESS SITES § 247.20 What are the road and trail prohibitions? (a) You cannot damage or leave in a damaged condition any road, trail, or segment thereof. (b) You cannot block...

  2. 17 CFR 247.772 - Exemption from the definition of “broker” for banks engaging in securities lending transactions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Exemption from the definition of âbrokerâ for banks engaging in securities lending transactions. 247.772 Section 247.772 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATION R-EXEMPTIONS AND...

  3. 17 CFR 247.772 - Exemption from the definition of “broker” for banks engaging in securities lending transactions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Exemption from the definition of âbrokerâ for banks engaging in securities lending transactions. 247.772 Section 247.772 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATION R-EXEMPTIONS AND...

  4. 17 CFR 247.772 - Exemption from the definition of “broker” for banks engaging in securities lending transactions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption from the definition of âbrokerâ for banks engaging in securities lending transactions. 247.772 Section 247.772 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATION R-EXEMPTIONS AND...

  5. 17 CFR 247.772 - Exemption from the definition of “broker” for banks engaging in securities lending transactions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Exemption from the definition of âbrokerâ for banks engaging in securities lending transactions. 247.772 Section 247.772 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATION R-EXEMPTIONS AND...

  6. 17 CFR 247.772 - Exemption from the definition of “broker” for banks engaging in securities lending transactions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Exemption from the definition of âbrokerâ for banks engaging in securities lending transactions. 247.772 Section 247.772 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATION R-EXEMPTIONS AND...

  7. 48 CFR 52.247-52 - Clearance and Documentation Requirements-Shipments to DOD Air or Water Terminal Transshipment...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Clearance and Documentation Requirements-Shipments to DOD Air or Water Terminal Transshipment Points. 52.247-52 Section 52.247-52 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES...

  8. 17 CFR 247.723 - Exemptions for special accounts, transferred accounts, foreign branches and a de minimis number...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... accounts, transferred accounts, foreign branches and a de minimis number of accounts. 247.723 Section 247... Exemptions for special accounts, transferred accounts, foreign branches and a de minimis number of accounts... dealer. (e) De minimis exclusion. A bank may, in determining its compliance with the chiefly compensated...

  9. 17 CFR 247.723 - Exemptions for special accounts, transferred accounts, foreign branches and a de minimis number...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... accounts, transferred accounts, foreign branches and a de minimis number of accounts. 247.723 Section 247... Exemptions for special accounts, transferred accounts, foreign branches and a de minimis number of accounts... dealer. (e) De minimis exclusion. A bank may, in determining its compliance with the chiefly compensated...

  10. 17 CFR 247.776 - Exemption from the definition of “broker” for banks effecting certain excepted or exempted...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... for its employee benefit plans. 247.776 Section 247.776 Commodity and Securities Exchanges SECURITIES... effecting certain excepted or exempted transactions in a company's securities for its employee benefit plans... benefit of an employee benefit plan account; (3) Any such security is obtained directly from: (i) The...

  11. 14 CFR 247.1 - Official mileage record of the Department of Transportation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Official mileage record of the Department of Transportation. 247.1 Section 247.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... airport-to-airport mileages pursuant to the provisions of Titles IV and X of the Federal Aviation Act of...

  12. THE ARAUCARIA PROJECT: THE DISTANCE TO THE SCULPTOR GALAXY NGC 247 FROM NEAR-INFRARED PHOTOMETRY OF CEPHEID VARIABLES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gieren, Wolfgang; Pietrzynski, Grzegorz; Szewczyk, Olaf

    2009-08-01

    We have obtained deep near-infrared images in J and K filters of four fields in the Sculptor Group spiral galaxy NGC 247 with the ESO VLT and Infrared Spectrometer and Array Camera. For a sample of 10 Cepheids in these fields, previously discovered by GarcIa-Varela et al. from optical wide-field images, we have determined mean J and K magnitudes and have constructed the period-luminosity (PL) relations in these bands. Using the near-infrared PL relations together with those in the optical V and I bands, we have determined a true distance modulus for NGC 247 of 27.64 mag, with a randommore » uncertainty of {+-}2% and a systematic uncertainty of {approx}4% which is dominated by the effect of unresolved stars on the Cepheid photometry. The mean reddening affecting the NGC 247 Cepheids of E(B - V) = 0.18 {+-} 0.02 mag is mostly produced in the host galaxy itself and is significantly higher than what was found in the previous optical Cepheid studies in NGC 247 of our own group, and Madore et al., leading to a 7% decrease in the previous optical Cepheid distance. As in other studies of our project, the distance modulus of NGC 247 we report is tied to an assumed Large Magellanic Cloud distance modulus of 18.50. Comparison with other distance measurements to NGC 247 shows that the present IR-based Cepheid distance is the most accurate among these determinations. With a distance of 3.4 Mpc, NGC 247 is about 1.5 Mpc more distant than NGC 55 and NGC 300, two other Sculptor Group spirals analyzed before with the same technique by our group.« less

  13. Development of exothermically cast single-crystal Mar-M 247 and derivative alloys

    NASA Technical Reports Server (NTRS)

    Strangman, T. E.; Hoppin, G. S., III; Phipps, C. M.; Harris, K.; Schwer, R. E.

    1980-01-01

    A low-cost, exothermic directional-solidification (DS) process was developed to produce single-crystal (SC) Mar-M 247 high-pressure turbine blades. Stress-rupture data indicated that SC Mar-M 247 provides only marginal improvements in longitudinal strength relative to the columnar grained DS material. Removal of grain boundary strengthening elements (B, C, Zr, Hf) from the Mar-M 247 composition (which are also melting point depressants) permitted the alloy to be solutioned at significantly higher temperatures. An order of magnitude improvement in rupture life relative to SC Mar-M 247 was observed for several derivative alloys at 103.5 MPa (15 KSI) and 1093 C. Rupture lives of the modified SC alloys were significantly affected by both alloy purity and heat treatment. Critical aspects of vacuum induction refining, exothermic casting technology, alloy development and heat treatment, which contributed to this new class of turbine blades, are reviewed

  14. 49 CFR 234.247 - Purpose of inspections and tests; removal from service of relay or device failing to meet test...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Purpose of inspections and tests; removal from service of relay or device failing to meet test requirements. 234.247 Section 234.247 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING...

  15. 49 CFR 234.247 - Purpose of inspections and tests; removal from service of relay or device failing to meet test...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Purpose of inspections and tests; removal from service of relay or device failing to meet test requirements. 234.247 Section 234.247 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING...

  16. 49 CFR 234.247 - Purpose of inspections and tests; removal from service of relay or device failing to meet test...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Purpose of inspections and tests; removal from service of relay or device failing to meet test requirements. 234.247 Section 234.247 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM...

  17. 49 CFR 234.247 - Purpose of inspections and tests; removal from service of relay or device failing to meet test...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Purpose of inspections and tests; removal from service of relay or device failing to meet test requirements. 234.247 Section 234.247 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING...

  18. 78 FR 49254 - Approval of Subzone Status; GE Transportation; Lawrence Park Township and Grove City, Pennsylvania

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... Status; GE Transportation; Lawrence Park Township and Grove City, Pennsylvania On May 16, 2013, the... activation limit of FTZ 247, on behalf of GE Transportation, in Lawrence Park Township and Grove City... establish Subzone 247A in Lawrence Park Township and Subzone 247B in Grove City are approved, subject to the...

  19. 48 CFR 52.247-3 - Capability To Perform a Contract for the Relocation of a Federal Office.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Capability To Perform a Contract for the Relocation of a Federal Office. 52.247-3 Section 52.247-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  20. 32 CFR Appendix C to Part 247 - Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and Distribution of...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Mailing of DoD Newspapers, Magazines, CE Guides...) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. C Appendix C to Part 247—Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and...

  1. 32 CFR Appendix C to Part 247 - Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and Distribution of...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Mailing of DoD Newspapers, Magazines, CE Guides...) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. C Appendix C to Part 247—Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and...

  2. 32 CFR Appendix C to Part 247 - Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and Distribution of...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Mailing of DoD Newspapers, Magazines, CE Guides...) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. C Appendix C to Part 247—Mailing of DoD Newspapers, Magazines, CE Guides, and Installation Maps; Sales and...

  3. 24 CFR 203.43i - Eligibility of mortgages on Hawaiian Home Lands insured pursuant to section 247 of the National...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Hawaiian Home Lands insured pursuant to section 247 of the National Housing Act. 203.43i Section 203.43i... Eligibility of mortgages on Hawaiian Home Lands insured pursuant to section 247 of the National Housing Act. (a) Eligibility. A mortgage on a homestead lease granted by the Department of Hawaiian Home Lands...

  4. 25 CFR 247.5 - What laws and regulations apply to the people who use these sites?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What laws and regulations apply to the people who use these sites? 247.5 Section 247.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND... people who use these sites? You may use access sites only if you obey the following rules: (a) You may...

  5. 17 CFR 247.740 - Defined terms relating to the sweep accounts exception from the definition of “broker.”

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Defined terms relating to the sweep accounts exception from the definition of âbroker.â 247.740 Section 247.740 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATION R-EXEMPTIONS AND DEFINITIONS RELATED TO THE EXCEPTIONS FOR BANKS FROM THE...

  6. 25 CFR 247.5 - What laws and regulations apply to the people who use these sites?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What laws and regulations apply to the people who use these sites? 247.5 Section 247.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND... people who use these sites? You may use access sites only if you obey the following rules: (a) You may...

  7. 25 CFR 247.5 - What laws and regulations apply to the people who use these sites?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What laws and regulations apply to the people who use these sites? 247.5 Section 247.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND... people who use these sites? You may use access sites only if you obey the following rules: (a) You may...

  8. 25 CFR 247.5 - What laws and regulations apply to the people who use these sites?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What laws and regulations apply to the people who use these sites? 247.5 Section 247.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND... people who use these sites? You may use access sites only if you obey the following rules: (a) You may...

  9. 25 CFR 247.5 - What laws and regulations apply to the people who use these sites?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What laws and regulations apply to the people who use these sites? 247.5 Section 247.5 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND... people who use these sites? You may use access sites only if you obey the following rules: (a) You may...

  10. Radiology 24/7 In-House Attending Coverage: Do Benefits Outweigh Cost?

    PubMed

    Coleman, Stephanie; Holalkere, Nagaraj Setty; O׳Malley, Julie; Doherty, Gemma; Norbash, Alexander; Kadom, Nadja

    2016-01-01

    Many radiology practices, including academic centers, are moving to in-house 24/7 attending coverage. This could be costly and may not be easily accepted by radiology trainees and attending radiologists. In this article, we evaluated the effects of 24/7 in-house attending coverage on patient care, costs, and qualitative aspects such as trainee education. We retrospectively collected report turnaround times (TAT) and work relative value units (wRVU). We compared these parameters between the years before and after the implementation of 24/7 in-house attending coverage. The cost to provide additional attending coverage was estimated from departmental financial reports. A qualitative survey of radiology residents and faculty was performed to study perceived effects on trainee education. There were decreases in report TAT following 24/7 attending implementation: 69% reduction in computed tomography, 43% reduction in diagnostic radiography, 7% reduction in magnetic resonance imaging, and 43% reduction in ultrasound. There was an average daytime wRVU decrease of 9%, although this was compounded by a decrease in total RVUs of the 2013 calendar year. The financial investment by the institution was estimated at $850,000. Qualitative data demonstrated overall positive feedback from trainees and faculty in radiology, although loss of independence was reported as a negative effect. TAT and wRVU metrics changed with implementation of 24/7 attending coverage, although these metrics do not directly relate to patient outcomes. Additional clinical benefits may include fewer discrepancies between preliminary and final reports that may improve emergency and inpatient department workflows and liability exposure. Radiologists reported the impression that clinicians appreciated 24/7 in-house attending coverage, particularly surgical specialists. Loss of trainee independence on call was a perceived disadvantage of 24/7 attending coverage and raised a concern that residency education outcomes could be adversely affected. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. 40 CFR 247.11 - Vehicular products.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.11 Vehicular... fluids, and gear oils, excluding marine and aviation oils. (b) Tires, excluding airplane tires. (c...

  12. 40 CFR 247.11 - Vehicular products.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.11 Vehicular... fluids, and gear oils, excluding marine and aviation oils. (b) Tires, excluding airplane tires. (c...

  13. 40 CFR 247.11 - Vehicular products.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROCUREMENT GUIDELINE FOR PRODUCTS CONTAINING RECOVERED MATERIALS Item Designations § 247.11 Vehicular... fluids, and gear oils, excluding marine and aviation oils. (b) Tires, excluding airplane tires. (c...

  14. Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.

    PubMed

    Kirby, Karen A; Ong, Yee Tsuey; Hachiya, Atsuko; Laughlin, Thomas G; Chiang, Leslie A; Pan, Yun; Moran, Jennifer L; Marchand, Bruno; Singh, Kamalendra; Gallazzi, Fabio; Quinn, Thomas P; Yoshimura, Kazuhisa; Murakami, Toshio; Matsushita, Shuzo; Sarafianos, Stefan G

    2015-01-01

    Humanized monoclonal antibody KD-247 targets the Gly(312)-Pro(313)-Gly(314)-Arg(315) arch of the third hypervariable (V3) loop of the HIV-1 surface glycoprotein. It potently neutralizes many HIV-1 clade B isolates, but not of other clades. To understand the molecular basis of this specificity, we solved a high-resolution (1.55 Å) crystal structure of the KD-247 antigen binding fragment and examined the potential interactions with various V3 loop targets. Unlike most antibodies, KD-247 appears to interact with its target primarily through light chain residues. Several of these interactions involve Arg(315) of the V3 loop. To evaluate the role of light chain residues in the recognition of the V3 loop, we generated 20 variants of KD-247 single-chain variable fragments with mutations in the antigen-binding site. Purified proteins were assessed for V3 loop binding using AlphaScreen technology and for HIV-1 neutralization. Our data revealed that recognition of the clade-specificity defining residue Arg(315) of the V3 loop is based on a network of interactions that involve Tyr(L32), Tyr(L92), and Asn(L27d) that directly interact with Arg(315), thus elucidating the molecular interactions of KD-247 with its V3 loop target. © FASEB.

  15. Burner Rig Hot Corrosion of Five Ni-Base Alloys Including Mar-M247

    NASA Technical Reports Server (NTRS)

    Nesbitt, James A.; Helmink, R.; Harris, K.; Erickson, G.

    2000-01-01

    The hot corrosion resistance of four new Ni-base superalloys was compared to that of Mar-M247 by testing in a Mach 0.3 burner rig at 900 C for 300 1-hr cycles. While the Al content was held the same as in the Mar-M247, the Cr and Co levels in the four new alloys were decreased while other strengthening elements (Re, Ta) were increased. Surprisingly, despite their lower Cr and Co contents, the hot corrosion behavior of all four new alloys was superior to that of the Mar-M247 alloy. The Mar-M247 alloy began to lose weight almost immediately whereas the other four alloys appeared to undergo an incubation period of 50-150 1-hr cycles. Examination of the cross-sectional microstructures showed regions of rampant corrosion attack (propagation stage) in all five alloys after 300 1-hr cycles . This rampant corrosion morphology was similar for each of the alloys with Ni and Cr sulfides located in an inner subscale region. The morphology of the attack suggests a classic "Type I", or high temperature, hot corrosion attack.

  16. Low-cost single-crystal turbine blades, volume 1

    NASA Technical Reports Server (NTRS)

    Strangman, T. E.; Heath, B.; Fujii, M.

    1983-01-01

    The exothermic casting process was successfully developed into a low cost nonproprietary method for producing single crystal (SC) castings. Casting yields were lower than expected, on the order of 20 percent, but it is felt that the casting yield could be significantly improved with minor modifications to the process. Single crystal Mar-M 247 and two derivative SC alloys were developed. NASAIR 100 and SC Alloy 3 were fully characterized through mechanical property testing. SC Mar-M 247 shows no significant improvement in strength over directionally solidified (DS) Mar-M 247, but the derivative alloys, NASAIR 100 and Alloy 3, show significant tensile and fatigue improvements. The 1000 hr/238 MPa (20 ksi) stress rupture capability compared to DS Mar-M 247 was improved over 28 C. Firtree testing, holography, and strain gauge rig testing were used to evaluate the effects of the anisotropic characteristics of single crystal materials. In general, the single crystal material behaved similarly to DS Mar-M 247. Two complete engine sets of SC HP turbine blades were cast using the exothermic casting process and fully machined.

  17. 48 CFR 247.001 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION 247.001 Definitions. For definitions of “Civil Reserve Air Fleet” and “Voluntary Intermodal Sealift Agreement,” see Joint Pub 1-02, DoD Dictionary of...

  18. Differential Susceptibilities of Anopheles albimanus and Anopheles pseudopunctipennis to Infections with Coindigenous Plasmodium vivax Variants VK210 and VK247 in Southern Mexico

    PubMed Central

    Gonzalez-Ceron, Lilia; Rodriguez, Mario H.; Nettel, Jose C.; Villarreal, Cuauhtemoc; Kain, Kevin C.; Hernandez, Juan E.

    1999-01-01

    The susceptibilities to coindigenous Plasmodium vivax of colonized Anopheles albimanus and Anopheles pseudopunctipennis from southern Mexico were investigated by simultaneous feeding with infected blood obtained from patients. The genes encoding circumsporozoite protein variant types (VK210 and VK247) in blood samples were determined by PCR and oligonucleotide probe hybridization. A. albimanus was more susceptible to VK210, and A. pseudopunctipennis was more susceptible to VK247. PMID:9864243

  19. Differential susceptibilities of Anopheles albimanus and Anopheles pseudopunctipennis to infections with coindigenous Plasmodium vivax variants VK210 and VK247 in southern Mexico.

    PubMed

    Gonzalez-Ceron, L; Rodriguez, M H; Nettel, J C; Villarreal, C; Kain, K C; Hernandez, J E

    1999-01-01

    The susceptibilities to coindigenous Plasmodium vivax of colonized Anopheles albimanus and Anopheles pseudopunctipennis from southern Mexico were investigated by simultaneous feeding with infected blood obtained from patients. The genes encoding circumsporozoite protein variant types (VK210 and VK247) in blood samples were determined by PCR and oligonucleotide probe hybridization. A. albimanus was more susceptible to VK210, and A. pseudopunctipennis was more susceptible to VK247.

  20. 32 CFR 247.2 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.2 Applicability. This... Heads of the DoD Components. (b) Does not apply to the Stars and Stripes (S&S) newspapers and business...

  1. 32 CFR 247.2 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.2 Applicability. This... Heads of the DoD Components. (b) Does not apply to the Stars and Stripes (S&S) newspapers and business...

  2. 32 CFR 247.2 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.2 Applicability. This... Heads of the DoD Components. (b) Does not apply to the Stars and Stripes (S&S) newspapers and business...

  3. 32 CFR 247.2 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.2 Applicability. This... Heads of the DoD Components. (b) Does not apply to the Stars and Stripes (S&S) newspapers and business...

  4. 32 CFR 247.2 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.2 Applicability. This... Heads of the DoD Components. (b) Does not apply to the Stars and Stripes (S&S) newspapers and business...

  5. 7 CFR 247.28 - Storage and inventory of commodities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.28 Storage and... must provide for storage of commodities that protects them from theft, spoilage, damage or destruction...

  6. 7 CFR 247.28 - Storage and inventory of commodities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.28 Storage and... must provide for storage of commodities that protects them from theft, spoilage, damage or destruction...

  7. 7 CFR 247.28 - Storage and inventory of commodities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.28 Storage and... must provide for storage of commodities that protects them from theft, spoilage, damage or destruction...

  8. 7 CFR 247.28 - Storage and inventory of commodities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.28 Storage and... must provide for storage of commodities that protects them from theft, spoilage, damage or destruction...

  9. 7 CFR 247.28 - Storage and inventory of commodities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.28 Storage and... must provide for storage of commodities that protects them from theft, spoilage, damage or destruction...

  10. 7 CFR 247.8 - Individuals applying to participate in CSFP.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.8..., color, national origin, age, sex, or disability. After informing the applicant (or adult parent or...

  11. 7 CFR 247.37 - Civil rights requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.37 Civil rights requirements... agencies must ensure that no person shall, on the grounds of race, color, national origin, age, sex, or...

  12. 7 CFR 247.37 - Civil rights requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.37 Civil rights requirements... agencies must ensure that no person shall, on the grounds of race, color, national origin, age, sex, or...

  13. 7 CFR 247.37 - Civil rights requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.37 Civil rights requirements... agencies must ensure that no person shall, on the grounds of race, color, national origin, age, sex, or...

  14. 7 CFR 247.37 - Civil rights requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.37 Civil rights requirements... agencies must ensure that no person shall, on the grounds of race, color, national origin, age, sex, or...

  15. 7 CFR 247.35 - Local agency appeals of State agency actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.35...; (3) An opportunity to confront and cross-examine witnesses; and (4) An opportunity to be represented...

  16. 7 CFR 247.35 - Local agency appeals of State agency actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.35...; (3) An opportunity to confront and cross-examine witnesses; and (4) An opportunity to be represented...

  17. 7 CFR 247.35 - Local agency appeals of State agency actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.35...; (3) An opportunity to confront and cross-examine witnesses; and (4) An opportunity to be represented...

  18. 7 CFR 247.35 - Local agency appeals of State agency actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.35...; (3) An opportunity to confront and cross-examine witnesses; and (4) An opportunity to be represented...

  19. 7 CFR 247.35 - Local agency appeals of State agency actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.35...; (3) An opportunity to confront and cross-examine witnesses; and (4) An opportunity to be represented...

  20. Low-cost single-crystal turbine blades, volume 2

    NASA Technical Reports Server (NTRS)

    Strangman, T. E.; Dennis, R. E.; Heath, B. R.

    1984-01-01

    The overall objectives of Project 3 were to develop the exothermic casting process to produce uncooled single-crystal (SC) HP turbine blades in MAR-M 247 and higher strength derivative alloys and to validate the materials process and components through extensive mechanical property testing, rig testing, and 200 hours of endurance engine testing. These Program objectives were achieved. The exothermic casting process was successfully developed into a low-cost nonproperietary method for producing single-crystal castings. Single-crystal MAR-M 247 and two derivatives DS alloys developed during this project, NASAIR 100 and SC Alloy 3, were fully characterized through mechanical property testing. SC MAR-M 247 shows no significant improvement in strength over directionally solidified (DS) MAR-M 247, but the derivative alloys, NASAIR 100 and Alloy 3, show significant tensile and fatigue improvements. Firtree testing, holography, and strain-gauge rig testing were used to determine the effects of the anisotropic characteristics of single-crystal materials. No undesirable characteristics were found. In general, the single-crystal material behaved similarly to DS MAR-M 247. Two complete engine sets of SC HP turbine blades were cast using the exothermic casting process and fully machined. These blades were successfully engine-tested.

  1. 7 CFR 247.31 - Audits and investigations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.31 Audits and investigations... and Budget under control number 0584-0293) ...

  2. 7 CFR 247.31 - Audits and investigations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.31 Audits and investigations... and Budget under control number 0584-0293) ...

  3. 7 CFR 247.31 - Audits and investigations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.31 Audits and investigations... and Budget under control number 0584-0293) ...

  4. 7 CFR 247.31 - Audits and investigations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.31 Audits and investigations... and Budget under control number 0584-0293) ...

  5. 7 CFR 247.31 - Audits and investigations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.31 Audits and investigations... and Budget under control number 0584-0293) ...

  6. Perceptions of 24/7 In-house Attending Coverage on Fellow Education and Autonomy in a Pediatric Cardiothoracic Intensive Care Unit.

    PubMed

    Owens, Sonal T; Owens, Gabe E; Rajput, Shaili H; Charpie, John R; Kidwell, Kelley M; Mullan, Patricia B

    2015-01-01

    The 24/7 in-house attending coverage is emerging as the standard of care in intensive care units. Implementation costs, workforce feasibility, and patient outcomes resulting from changes in physician staffing are widely debated topics. Understanding the impact of staffing models on the learning environment for medical trainees and faculty is equally warranted, particularly with respect to trainee education and autonomy. This study aims to elicit the perceptions of pediatric cardiology fellows and attendings toward 24/7 in-house attending coverage and its effect on fellow education and autonomy. We surveyed pediatric cardiology fellows and attendings practicing in the pediatric cardiothoracic intensive care unit (PCTU) of a large, university-affiliated medical center, using structured Likert response items and open-ended questions, prior to and following the transition to 24/7 in-house attending coverage. All (100%) trainees and faculty completed all surveys. Both prior to and following transition to 24/7 in-house attending coverage, all fellows, and the majority of attendings agreed that the overnight call experience benefited fellow education. At baseline, trainees identified limited circumstances in which on-site attending coverage would be critical. Preimplementation concerns that 24/7 in-house attending coverage would negatively affect the education of fellows were not reflected following actual implementation of the new staffing policy. However, based upon open-ended questions, fellow autonomy was affected by the new paradigm, with fellows and attendings reporting decreased "appropriateness" of autonomy after implementation. Our prospective study, showing initial concerns about limiting the learning environment in transitioning to 24/7 in-house attending coverage did not result in diminished perceptions of the educational experience for our fellows but revealed an expected decrease in fellow autonomy. The study indirectly facilitated open discussions about methods to preserve fellow education and warranted autonomy in our PCTU; however, continued efforts are needed to achieve the optimal balance between supervised training and the transition to autonomous practice. © 2015 Wiley Periodicals, Inc.

  7. Catalytic mechanism of a family 3 beta-glucosidase and mutagenesis study on residue Asp-247.

    PubMed Central

    Li, Y K; Chir, J; Chen, F Y

    2001-01-01

    A family 3 beta-glucosidase (EC 3.2.1.21) from Flavobacterium meningosepticum has been cloned and overexpressed. The mechanistic action of the enzyme was probed by NMR spectroscopy and kinetic investigations, including substrate reactivity, secondary kinetic isotope effects and inhibition studies. The stereochemistry of enzymic hydrolysis was identified as occurring with the retention of an anomeric configuration, indicating a double-displacement reaction. Based on the k(cat) values with a series of aryl glucosides, a Bronsted plot with a concave-downward shape was constructed. This biphasic behaviour is consistent with a two-step mechanism involving the formation and breakdown of a glucosyl-enzyme intermediate. The large Bronsted constant (beta=-0.85) for the leaving-group-dependent portion (pK(a) of leaving phenols >7) indicates substantial bond cleavage at the transition state. Secondary deuterium kinetic isotope effects with 2,4-dinitrophenyl beta-D-glucopyanoside, o-nitrophenyl beta-D-glucopyanoside and p-cyanophenyl beta-D-glucopyanoside as substrates were 1.17+/-0.02, 1.19+/-0.02 and 1.04+/-0.02 respectively. These results support an S(N)1-like mechanism for the deglucosylation step and an S(N)2-like mechanism for the glucosylation step. Site-directed mutagenesis was also performed to study essential amino acid residues. The activities (k(cat)/K(m)) of the D247G and D247N mutants were 30000- and 200000-fold lower respectively than that of the wild-type enzyme, whereas the D247E mutant retained 20% of wild-type activity. These results indicate that Asp-247 is an essential amino acid. It is likely that this residue functions as a nucleophile in the reaction. This conclusion is supported by the kinetics of the irreversible inactivation of the wild-type enzyme by conduritol-B-epoxide, compared with the much slower inhibition of the D247E mutant and the lack of irreversible inhibition of the D247G mutant. PMID:11311148

  8. 48 CFR 247.301-70 - Definition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... logistics services. Some examples of logistics services are the management of transportation, demand forecasting, information management, inventory maintenance, warehousing, and distribution. [65 FR 50145, Aug..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 247.301-70...

  9. 48 CFR 247.301-70 - Definition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... logistics services. Some examples of logistics services are the management of transportation, demand forecasting, information management, inventory maintenance, warehousing, and distribution. [65 FR 50145, Aug..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 247.301-70...

  10. 48 CFR 247.301-70 - Definition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... logistics services. Some examples of logistics services are the management of transportation, demand forecasting, information management, inventory maintenance, warehousing, and distribution. [65 FR 50145, Aug..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 247.301-70...

  11. 48 CFR 247.301-70 - Definition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... logistics services. Some examples of logistics services are the management of transportation, demand forecasting, information management, inventory maintenance, warehousing, and distribution. [65 FR 50145, Aug..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 247.301-70...

  12. 48 CFR 247.301-70 - Definition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... logistics services. Some examples of logistics services are the management of transportation, demand forecasting, information management, inventory maintenance, warehousing, and distribution. [65 FR 50145, Aug..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 247.301-70...

  13. 32 CFR 247.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.3 Definitions... endorsement of content by, the Department of Defense. (1) CE newspapers. Newspapers published by commercial...

  14. 32 CFR 247.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.3 Definitions... endorsement of content by, the Department of Defense. (1) CE newspapers. Newspapers published by commercial...

  15. 32 CFR 247.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.3 Definitions... endorsement of content by, the Department of Defense. (1) CE newspapers. Newspapers published by commercial...

  16. 32 CFR 247.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.3 Definitions... endorsement of content by, the Department of Defense. (1) CE newspapers. Newspapers published by commercial...

  17. 32 CFR 247.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.3 Definitions... endorsement of content by, the Department of Defense. (1) CE newspapers. Newspapers published by commercial...

  18. 25 CFR 247.17 - What are the restrictions on fires?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREATY FISHING ACCESS SITES § 247.17 What are the restrictions on fires? (a) You cannot burn timber, trees, slash, brush or grass unless you have a permit issued by the Area Director or his designee. (b...

  19. 25 CFR 247.17 - What are the restrictions on fires?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREATY FISHING ACCESS SITES § 247.17 What are the restrictions on fires? (a) You cannot burn timber, trees, slash, brush or grass unless you have a permit issued by the Area Director or his designee. (b...

  20. 25 CFR 247.17 - What are the restrictions on fires?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREATY FISHING ACCESS SITES § 247.17 What are the restrictions on fires? (a) You cannot burn timber, trees, slash, brush or grass unless you have a permit issued by the Area Director or his designee. (b...

  1. 25 CFR 247.17 - What are the restrictions on fires?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREATY FISHING ACCESS SITES § 247.17 What are the restrictions on fires? (a) You cannot burn timber, trees, slash, brush or grass unless you have a permit issued by the Area Director or his designee. (b...

  2. 25 CFR 247.17 - What are the restrictions on fires?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREATY FISHING ACCESS SITES § 247.17 What are the restrictions on fires? (a) You cannot burn timber, trees, slash, brush or grass unless you have a permit issued by the Area Director or his designee. (b...

  3. 32 CFR Appendix A to Part 247 - Funded Newspapers and Magazines

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... images used will be in compliance with § 247.4(r). E. Assignment of personnel. Military and DoD civilian... published in funded publications. J. Employment and gratuities. DoD personnel shall not accept any...

  4. 32 CFR Appendix A to Part 247 - Funded Newspapers and Magazines

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... images used will be in compliance with § 247.4(r). E. Assignment of personnel. Military and DoD civilian... published in funded publications. J. Employment and gratuities. DoD personnel shall not accept any...

  5. 32 CFR Appendix A to Part 247 - Funded Newspapers and Magazines

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... images used will be in compliance with § 247.4(r). E. Assignment of personnel. Military and DoD civilian... published in funded publications. J. Employment and gratuities. DoD personnel shall not accept any...

  6. 32 CFR Appendix A to Part 247 - Funded Newspapers and Magazines

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... images used will be in compliance with § 247.4(r). E. Assignment of personnel. Military and DoD civilian... published in funded publications. J. Employment and gratuities. DoD personnel shall not accept any...

  7. 32 CFR Appendix A to Part 247 - Funded Newspapers and Magazines

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... images used will be in compliance with § 247.4(r). E. Assignment of personnel. Military and DoD civilian... published in funded publications. J. Employment and gratuities. DoD personnel shall not accept any...

  8. 7 CFR 247.34 - Management reviews.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.34 Management reviews. (a) What must..., nutrition education, civil rights compliance, food storage practices, inventory controls, and financial...

  9. 7 CFR 247.34 - Management reviews.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.34 Management reviews. (a) What must..., nutrition education, civil rights compliance, food storage practices, inventory controls, and financial...

  10. 7 CFR 247.34 - Management reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.34 Management reviews. (a) What must..., nutrition education, civil rights compliance, food storage practices, inventory controls, and financial...

  11. 7 CFR 247.34 - Management reviews.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.34 Management reviews. (a) What must..., nutrition education, civil rights compliance, food storage practices, inventory controls, and financial...

  12. 78 FR 19413 - Listing of Color Additives Exempt From Certification; Reactive Blue 246 and Reactive Blue 247...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    .... Studies included guinea pig maximization studies, in vivo ocular irritation studies in rabbits, and... C. I. Reactive Blue 247. Studies included guinea pig maximization studies, in vivo ocular irritation...

  13. Structure-Based Engineering of Methionine Residues in the Catalytic Cores of Alkaline Amylase from Alkalimonas amylolytica for Improved Oxidative Stability

    PubMed Central

    Yang, Haiquan; Wang, Mingxing; Li, Jianghua; Wang, Nam Sun; Du, Guocheng

    2012-01-01

    This work aims to improve the oxidative stability of alkaline amylase from Alkalimonas amylolytica through structure-based site-directed mutagenesis. Based on an analysis of the tertiary structure, five methionines (Met 145, Met 214, Met 229, Met 247, and Met 317) were selected as the mutation sites and individually replaced with leucine. In the presence of 500 mM H2O2 at 35°C for 5 h, the wild-type enzyme and the M145L, M214L, M229L, M247L, and M317L mutants retained 10%, 28%, 46%, 28%, 72%, and 43% of the original activity, respectively. Concomitantly, the alkaline stability, thermal stability, and catalytic efficiency of the M247L mutant were also improved. The pH stability of the mutants (M145L, M214L, M229L, and M317L) remained unchanged compared to that of the wild-type enzyme, while the stable pH range of the M247L mutant was extended from pH 7.0 to 11.0 for the wild type to pH 6.0 to 12.0 for the mutant. The wild-type enzyme lost its activity after incubation at 50°C for 2 h, and the M145L, M214L, M229L, and M317L mutants retained less than 14% of the activity, whereas the M247L mutant retained 34% of the activity under the same conditions. Compared to the wild-type enzyme, the kcat values of the M145L, M214L, M229L, and M317L mutants decreased, while that of the M247L mutant increased slightly from 5.0 × 104 to 5.6 × 104 min−1. The mechanism responsible for the increased oxidative stability, alkaline stability, thermal stability, and catalytic efficiency of the M247L mutant was further analyzed with a structure model. The combinational mutants were also constructed, and their biochemical properties were characterized. The resistance of the wild-type enzyme and the mutants to surfactants and detergents was also investigated. Our results indicate that the M247L mutant has great potential in the detergent and textile industries. PMID:22865059

  14. Structure-guided systems-level engineering of oxidation-prone methionine residues in catalytic domain of an alkaline α-amylase from Alkalimonas amylolytica for significant improvement of both oxidative stability and catalytic efficiency.

    PubMed

    Yang, Haiquan; Liu, Long; Shin, Hyun-dong; Li, Jianghua; Du, Guocheng; Chen, Jian

    2013-01-01

    High oxidative stability and catalytic efficiency are required for the alkaline α-amylases to keep the enzymatic performance under the harsh conditions in detergent industries. In this work, we attempted to significantly improve both the oxidative stability and catalytic efficiency of an alkaline α-amylase from Alkalimonas amylolytica by engineering the five oxidation-prone methionine residues around the catalytic domain via a systematic approach. Specifically, based on the tertiary structure analysis, five methionines (Met 145, Met 214, Met 229, Met 247 and Met 317) were individually substituted with oxidation-resistant threonine, isoleucine and alaline, respectively. Among the created 15 mutants, 7 mutants M145A, M145I, M214A, M229A, M229T, M247T and M317I showed significantly enhanced oxidative stability or catalytic efficiency. In previous work, we found that the replacement of M247 with leucine could significantly improve the oxidative stability. Thus, these 8 positive mutants (M145A, M145I, M214A, M229A, M229T, M247T, M247L and M317I) were used to conduct the second round of combinational mutations. Among the constructed 85 mutants (25 two-point mutants, 36 three-point mutants, 16 four-point mutants and 8 five-point mutants), the mutant M145I-214A-229T-247T-317I showed a 5.4-fold increase in oxidative stability and a 3.0-fold increase in catalytic efficiency. Interestingly, the specific activity, alkaline stability and thermal stability of this mutant were also increased. The increase of salt bridge and hydrogen bonds around the catalytic domain contributed to the significantly improved catalytic efficiency and stability, as revealed by the three-dimensional structure model of wild-type alkaline α-amylase and its mutant M145I-214A-229T-247T-317I. With the significantly improved oxidative stability and catalytic efficiency, the mutant M145I-214A-229T-247T-317I has a great potential as a detergent additive, and this structure-guided systems engineering strategy may be useful for the protein engineering of the other microbial enzymes to fulfill industrial requirements.

  15. 32 CFR 247.5 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.5 Responsibilities. (a.... (5) Monitor effectiveness of business and financial operations of DoD publications and provide business counsel and assistance, as appropriate. (6) Sponsor a DoD Interservice Newspaper Committee and a...

  16. 32 CFR 247.5 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.5 Responsibilities. (a.... (5) Monitor effectiveness of business and financial operations of DoD publications and provide business counsel and assistance, as appropriate. (6) Sponsor a DoD Interservice Newspaper Committee and a...

  17. 32 CFR 247.5 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.5 Responsibilities. (a.... (5) Monitor effectiveness of business and financial operations of DoD publications and provide business counsel and assistance, as appropriate. (6) Sponsor a DoD Interservice Newspaper Committee and a...

  18. 32 CFR 247.5 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.5 Responsibilities. (a.... (5) Monitor effectiveness of business and financial operations of DoD publications and provide business counsel and assistance, as appropriate. (6) Sponsor a DoD Interservice Newspaper Committee and a...

  19. 7 CFR 247.14 - Other public assistance programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... children applicants with written information on the following nutrition, health, or public assistance....14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.14 Other public...

  20. 7 CFR 247.14 - Other public assistance programs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... children applicants with written information on the following nutrition, health, or public assistance....14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.14 Other public...

  1. 7 CFR 247.14 - Other public assistance programs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... children applicants with written information on the following nutrition, health, or public assistance....14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.14 Other public...

  2. 7 CFR 247.14 - Other public assistance programs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... children applicants with written information on the following nutrition, health, or public assistance....14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.14 Other public...

  3. 7 CFR 247.14 - Other public assistance programs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... children applicants with written information on the following nutrition, health, or public assistance....14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.14 Other public...

  4. 32 CFR 247.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.1 Purpose. This part implements... concerning authorized DoD Appropriated Funded (APF) newspapers and magazines, and Civilian Enterprise (CE) newspapers, magazines, guides, and installation maps in support of the DoD Internal Information Program. 1...

  5. 7 CFR 247.7 - Selection of local agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.7 Selection of local agencies... the Office of Management and Budget under control number 0584-0293) ...

  6. 7 CFR 247.7 - Selection of local agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.7 Selection of local agencies... the Office of Management and Budget under control number 0584-0293) ...

  7. 7 CFR 247.7 - Selection of local agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.7 Selection of local agencies... the Office of Management and Budget under control number 0584-0293) ...

  8. 7 CFR 247.7 - Selection of local agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.7 Selection of local agencies... the Office of Management and Budget under control number 0584-0293) ...

  9. Amino Acid Residues Critical for Endoplasmic Reticulum Export and Trafficking of Platelet-activating Factor Receptor*

    PubMed Central

    Hirota, Nobuaki; Yasuda, Daisuke; Hashidate, Tomomi; Yamamoto, Teruyasu; Yamaguchi, Satoshi; Nagamune, Teruyuki; Nagase, Takahide; Shimizu, Takao; Nakamura, Motonao

    2010-01-01

    Several residues are conserved in the transmembrane domains (TMs) of G-protein coupled receptors. Here we demonstrate that a conserved proline, Pro247, in TM6 of platelet-activating factor receptor (PAFR) is required for endoplasmic reticulum (ER) export and trafficking after agonist-induced internalization. Alanine-substituted mutants of the conserved residues of PAFRs, including P247A, were retained in the ER. Because a PAFR antagonist, Y-24180, acted as a pharmacological chaperone to rescue ER retention, this retention is due to misfolding of PAFR. Methylcarbamyl (mc)-PAF, a PAFR agonist, did not increase the cell surface expression of P247A, even though another ER-retained mutant, D63A, was effectively trafficked. Signaling and accumulation of the receptors in the early endosomes were observed in the mc-PAF-treated P247A-expressing cells, suggesting that P247A was trafficked to the cell surface by mc-PAF, and thereafter disappeared from the surface due to aberrant trafficking, e.g. enhanced internalization, deficiency in recycling, and/or accelerated degradation. The aberrant trafficking was confirmed with a sortase-A-mediated method for labeling cell surface proteins. These results demonstrate that the conserved proline in TM6 is crucial for intracellular trafficking of PAFR. PMID:20007715

  10. 7 CFR 247.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.1 Definitions. Following is a list of... reached their sixth birthday. Commodities means nutritious foods purchased by USDA to supplement the diets...

  11. 7 CFR 247.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.1 Definitions. Following is a list of... reached their sixth birthday. Commodities means nutritious foods purchased by USDA to supplement the diets...

  12. 7 CFR 247.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.1 Definitions. Following is a list of... reached their sixth birthday. Commodities means nutritious foods purchased by USDA to supplement the diets...

  13. 7 CFR 247.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.1 Definitions. Following is a list of... reached their sixth birthday. Commodities means nutritious foods purchased by USDA to supplement the diets...

  14. 7 CFR 247.12 - Rights and responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...; and (3) The local agency will provide information on other nutrition, health, or assistance programs... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.12 Rights and responsibilities...

  15. 7 CFR 247.12 - Rights and responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; and (3) The local agency will provide information on other nutrition, health, or assistance programs... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.12 Rights and responsibilities...

  16. 7 CFR 247.20 - Program violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.20 Program violations. (a) What are... determines that disqualification would result in a serious health risk, the disqualification may be waived...

  17. 7 CFR 247.12 - Rights and responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; and (3) The local agency will provide information on other nutrition, health, or assistance programs... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.12 Rights and responsibilities...

  18. 7 CFR 247.20 - Program violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.20 Program violations. (a) What are... determines that disqualification would result in a serious health risk, the disqualification may be waived...

  19. 7 CFR 247.12 - Rights and responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; and (3) The local agency will provide information on other nutrition, health, or assistance programs... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.12 Rights and responsibilities...

  20. 7 CFR 247.12 - Rights and responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; and (3) The local agency will provide information on other nutrition, health, or assistance programs... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.12 Rights and responsibilities...

  1. 48 CFR 52.247-53 - Freight Classification Description.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Freight Classification....247-53 Freight Classification Description. As prescribed in 47.305-9(b)(1), insert the following... modifications of previously shipped items, and different freight classifications may apply: Freight...

  2. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a) How long is the certification period? (1) Women, infants, and children. For women, infants, and children, the State agency must establish certification periods that may not exceed 6 months in length...

  3. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a) How long is the certification period? (1) Women, infants, and children. For women, infants, and children, the State agency must establish certification periods that may not exceed 6 months in length...

  4. 7 CFR 247.11 - Applicants exceed caseload levels.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.11 Applicants... include the date of application and information necessary to allow the local agency to contact the...

  5. 7 CFR 247.20 - Program violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.20 Program violations. (a) What are... of disqualification from CSFP at least 15 days before the effective date of disqualification. The...

  6. 48 CFR 52.247-53 - Freight Classification Description.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... modifications of previously shipped items, and different freight classifications may apply: Freight... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Freight Classification....247-53 Freight Classification Description. As prescribed in 47.305-9(b)(1), insert the following...

  7. 48 CFR 52.247-53 - Freight Classification Description.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... modifications of previously shipped items, and different freight classifications may apply: Freight... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Freight Classification....247-53 Freight Classification Description. As prescribed in 47.305-9(b)(1), insert the following...

  8. 48 CFR 52.247-53 - Freight Classification Description.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Freight Classification....247-53 Freight Classification Description. As prescribed in 47.305-9(b)(1), insert the following... modifications of previously shipped items, and different freight classifications may apply: Freight...

  9. 48 CFR 52.247-53 - Freight Classification Description.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Freight Classification....247-53 Freight Classification Description. As prescribed in 47.305-9(b)(1), insert the following... modifications of previously shipped items, and different freight classifications may apply: Freight...

  10. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State... serving women, infants, and children, program outreach, and nutrition education. (Collaboration with the...

  11. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State... serving women, infants, and children, program outreach, and nutrition education. (Collaboration with the...

  12. 7 CFR 247.6 - State Plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.6 State Plan. (a) What is the State... serving women, infants, and children, program outreach, and nutrition education. (Collaboration with the...

  13. 25 CFR 247.8 - What am I responsible for if I use the facilities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.8 What am I responsible for if I use the facilities? You... you occupy the site, including: (1) Tents; (2) Tepees; (3) Campers; (4) Mobile trailers; (5) Temporary...

  14. 24/7 in-house intensivist coverage and fellowship education: a cross-sectional survey of academic medical centers in the United States.

    PubMed

    Diaz-Guzman, Enrique; Colbert, Colleen Y; Mannino, David M; Davenport, Daniel L; Arroliga, Alejandro C

    2012-04-01

    The objectives of this study were to determine the current staffing models of practice and the frequency of 24/7 coverage in academic medical centers in the United States and to assess the perceptions of critical care trainees and program directors toward these models. A cross-sectional national survey was conducted using an Internet-based survey platform. The survey was distributed to fellows and program directors of 374 critical care training programs in US academic medical centers. We received 518 responses: 138 from program directors (PDs) (37% of 374 programs) and 380 fellow responses. Coverage by a board-certified or board-eligible intensivist physician 24/7 was reported by 33% of PD respondents and was more common among pediatric and surgical critical care programs. Mandatory in-house call for critical care trainees was reported by 48% of the PDs. Mandatory call was also more common among pediatric-critical care programs compared with the rest (P < .001). Advanced nurse practitioners with critical care training were reported available by 27% of the PDs. The majority of respondents believed that 24/7 coverage would be associated with better patient care in the ICU and improved education for the fellows, although 65% of them believed this model would have a negative impact on trainees' autonomy. Intensivist coverage 24/7 was not commonly used in US academic centers responding to our survey. Significant differences in coverage models among critical care medicine specialties appear to exist. Program director and trainee respondents believed that 24/7 coverage was associated with better outcomes and education but also expressed concerns about the impact of this model on fellows' autonomy.

  15. 48 CFR 52.247-6 - Financial Statement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....247-6 Financial Statement. As prescribed in 47.207-1(e), insert the following provision in solicitations for transportation or for transportation-related services to ensure that offerors are prepared to... furnish the Government with a current certified statement of the offeror's financial condition and such...

  16. 48 CFR 52.247-6 - Financial Statement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....247-6 Financial Statement. As prescribed in 47.207-1(e), insert the following provision in solicitations for transportation or for transportation-related services to ensure that offerors are prepared to... furnish the Government with a current certified statement of the offeror's financial condition and such...

  17. 7 CFR 247.19 - Dual participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.19 Dual participation. (a) What must... determines that disqualification would result in a serious health risk. The local agency must also initiate a...

  18. 7 CFR 247.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.1 Definitions. Following is a list of.... FNS means the Food and Nutrition Service. Infants means persons under one year of age. Local agency...

  19. 7 CFR 247.29 - Reports and recordkeeping.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.29 Reports and recordkeeping... liability for any improper distribution of, use of, loss of, or damage to commodities, and the results... number of program participants in each population category (e.g., infants, children, and elderly); (ii...

  20. 7 CFR 247.29 - Reports and recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.29 Reports and recordkeeping... liability for any improper distribution of, use of, loss of, or damage to commodities, and the results... number of program participants in each population category (e.g., infants, children, and elderly); (ii...

  1. Field testing of hand-held infrared thermography, phase II TPF-5(247) : final report.

    DOT National Transportation Integrated Search

    2016-05-01

    This report is the second of two volumes that document results from the pooled fund study TPF-5 (247), Development of : Handheld Infrared Thermography, Phase II. The interim report (volume I) studied the implementation of handheld thermography : by p...

  2. 7 CFR 247.26 - Return of administrative funds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.26 Return of administrative... legislatively mandated grant per assigned caseload slot. (Approved by the Office of Management and Budget under...

  3. 7 CFR 247.26 - Return of administrative funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.26 Return of administrative... legislatively mandated grant per assigned caseload slot. (Approved by the Office of Management and Budget under...

  4. 7 CFR 247.26 - Return of administrative funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.26 Return of administrative... legislatively mandated grant per assigned caseload slot. (Approved by the Office of Management and Budget under...

  5. 7 CFR 247.26 - Return of administrative funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.26 Return of administrative... legislatively mandated grant per assigned caseload slot. (Approved by the Office of Management and Budget under...

  6. 7 CFR 247.29 - Reports and recordkeeping.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.29 Reports and recordkeeping... FNS. (Approved by the Office of Management and Budget under control numbers 0584-0025, 0584-0293) [70...

  7. 7 CFR 247.29 - Reports and recordkeeping.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.29 Reports and recordkeeping... FNS. (Approved by the Office of Management and Budget under control numbers 0584-0025, 0584-0293) [70...

  8. 7 CFR 247.26 - Return of administrative funds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.26 Return of administrative... legislatively mandated grant per assigned caseload slot. (Approved by the Office of Management and Budget under...

  9. 7 CFR 247.29 - Reports and recordkeeping.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.29 Reports and recordkeeping... FNS. (Approved by the Office of Management and Budget under control numbers 0584-0025, 0584-0293) [70...

  10. 48 CFR 52.247-28 - Contractor's Invoices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contractor's Invoices. 52....247-28 Contractor's Invoices. As prescribed in 47.207-9(c), insert the following clause in... services: Contractor's Invoices (APR 1984) The Contractor shall submit itemized invoices as instructed by...

  11. 32 CFR Appendix B to Part 247 - CE Publications

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. B... as practical to generate maximum savings to the Department of Defense. In so doing, care must be...

  12. 32 CFR Appendix B to Part 247 - CE Publications

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS Pt. 247, App. B... as practical to generate maximum savings to the Department of Defense. In so doing, care must be...

  13. The void in the Sculptor group spiral galaxy NGC 247

    NASA Astrophysics Data System (ADS)

    Wagner-Kaiser, R.; De Maio, T.; Sarajedini, A.; Chakrabarti, S.

    2014-10-01

    The dwarf galaxy NGC 247, located in the Sculptor Filament, displays an apparent void on the north side of its spiral disc. The existence of the void in the disc of this dwarf galaxy has been known for some time, but the exact nature and cause of this strange feature has remained unclear. We investigate the properties of the void in the disc of NGC 247 using photometry of archival Hubble Space Telescope data to analyse the stars in and around this region. Based on a grid of isochrones from log(t) = 6.8 to 10.0, we assign ages using nearest-neighbour interpolation. Examination of the spatial variation of these ages across the galaxy reveals an age difference between stars located inside the void region and stars located outside this region. We speculate that the void in NGC 247 's stellar disc may be due to a recent interaction with a nearly dark subhalo that collided with the disc and could account for the long-lived nature of the void.

  14. Galaxy NGC 247

    NASA Technical Reports Server (NTRS)

    2003-01-01

    This image of the dwarf spiral galaxy NGC 247 was taken by Galaxy Evolution Explorer on October 13, 2003, in a single orbit exposure of 1600 seconds. The region that looks like a 'hole' in the upper part of the galaxy is a location with a deficit of gas and therefore a lower star formation rate and ultraviolet brightness. Optical images of this galaxy show a bright star on the southern edge. This star is faint and red in the Galaxy Evolution Explorer ultraviolet image, revealing that it is a foreground star in our Milky Way galaxy. The string of background galaxies to the North-East (upper left) of NGC 247 is 355 million light years from our Milky Way galaxy whereas NGC 247 is a mere 9 million light years away. The faint blue light that can be seen in the Galaxy Evolution Explorer image of the upper two of these background galaxies may indicate that they are in the process of merging together.

  15. Galaxy NGC 247

    NASA Image and Video Library

    2003-12-10

    This image of the dwarf spiral galaxy NGC 247 was taken by Galaxy Evolution Explorer on October 13, 2003, in a single orbit exposure of 1600 seconds. The region that looks like a "hole" in the upper part of the galaxy is a location with a deficit of gas and therefore a lower star formation rate and ultraviolet brightness. Optical images of this galaxy show a bright star on the southern edge. This star is faint and red in the Galaxy Evolution Explorer ultraviolet image, revealing that it is a foreground star in our Milky Way galaxy. The string of background galaxies to the North-East (upper left) of NGC 247 is 355 million light years from our Milky Way galaxy whereas NGC 247 is a mere 9 million light years away. The faint blue light that can be seen in the Galaxy Evolution Explorer image of the upper two of these background galaxies may indicate that they are in the process of merging together. http://photojournal.jpl.nasa.gov/catalog/PIA04922

  16. Evidence for live 247Cm in the early solar system

    USGS Publications Warehouse

    Tatsumoto, M.; Shimamura, T.

    1980-01-01

    Variations of the 238U/235U ratio in the Allende meteorite, ranging from -35% to + 19%, are interpreted as evidence of live 247Cm in the early Solar System. The amounts of these and other r-products in the Solar System indicate values of (9,000??3,000) Myr for the age of the Galaxy and ??? 8 Myr for the time between the end of nucleosynthesis and the formation of meteoritic grains. Three possible explanations are presented for the different values of the latter time period which are indicated by the decay products of 247Cm, 26Al, 244Pu and 129I. ?? 1980 Nature Publishing Group.

  17. 43 CFR 24.7 - Exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-FEDERAL RELATIONSHIPS § 24.7 Exemptions. (a) Exempted from this policy are the following: (1) The control and regulation by the United States, in the area in which an international convention or treaty... covered under any international treaty or convention to which the United States is a party; (2) Any...

  18. 48 CFR 52.247-57 - Transportation Transit Privilege Credits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Transportation Transit... Clauses 52.247-57 Transportation Transit Privilege Credits. As prescribed in 47.305-13(b)(4), insert the... reduce transportation costs through the use of transit credits: Transportation Transit Privilege Credits...

  19. 48 CFR 52.247-57 - Transportation Transit Privilege Credits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Transportation Transit... Clauses 52.247-57 Transportation Transit Privilege Credits. As prescribed in 47.305-13(b)(4), insert the... reduce transportation costs through the use of transit credits: Transportation Transit Privilege Credits...

  20. 48 CFR 52.247-57 - Transportation Transit Privilege Credits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Transportation Transit... Clauses 52.247-57 Transportation Transit Privilege Credits. As prescribed in 47.305-13(b)(4), insert the... reduce transportation costs through the use of transit credits: Transportation Transit Privilege Credits...

  1. 48 CFR 52.247-57 - Transportation Transit Privilege Credits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Transportation Transit... Clauses 52.247-57 Transportation Transit Privilege Credits. As prescribed in 47.305-13(b)(4), insert the... reduce transportation costs through the use of transit credits: Transportation Transit Privilege Credits...

  2. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a... and Budget under control number 0584-0293) [70 FR 47063, Aug. 11, 2005, as amended at 75 FR 5879, Feb...

  3. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a... and Budget under control number 0584-0293) [70 FR 47063, Aug. 11, 2005, as amended at 75 FR 5879, Feb...

  4. 7 CFR 247.16 - Certification period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.16 Certification period. (a... and Budget under control number 0584-0293) [70 FR 47063, Aug. 11, 2005, as amended at 75 FR 5879, Feb...

  5. 14 CFR 135.247 - Pilot qualifications: Recent experience.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot qualifications: Recent experience... Flight Crewmember Requirements § 135.247 Pilot qualifications: Recent experience. (a) No certificate holder may use any person, nor may any person serve, as pilot in command of an aircraft carrying...

  6. 14 CFR 135.247 - Pilot qualifications: Recent experience.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Pilot qualifications: Recent experience... Flight Crewmember Requirements § 135.247 Pilot qualifications: Recent experience. (a) No certificate holder may use any person, nor may any person serve, as pilot in command of an aircraft carrying...

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soares Azevedo e Silva, Paulo Ricardo, E-mail: paulori@alunos.eel.usp.br; Baldan, Renato, E-mail: renato@ppgem.eel.usp.br; Nunes, Carlos Angelo, E-mail: cnunes@demar.eel.usp.br

    MAR-M247 superalloy has excellent mechanical properties and good oxidation resistance at elevated temperatures. Niobium is an element known as {gamma} Prime phase hardener in nickel-based superalloys, besides promoting homogeneous distribution of MC carbides. This work is inserted in a project that aims to evaluate the total replacement of tantalum by niobium atoms in MAR-M247 superalloy (10.2 Co, 10.2 W, 8.5Cr, 5.6 Al, 1.6 Nb, 1.4 Hf, 1.1 Ti, 0.7 Mo, 0.15 C, 0.06 Zr, 0.015 B, Ni balance-wt.%). Based on microstructural characterizations (SEM and FEG-SEM, both with EDS) of the as-cast material and heat-treated materials as well as utilizing Thermocalcmore » simulations and experiments of differential thermal analysis (DTA), heat-treatment at 1260 Degree-Sign C for 8 h was chosen as an ideal condition for the solution of Nb-modified MAR-M247 superalloy. The hardness of as-cast and ideally solution treated materials was 390 {+-} 14 HV and 415 {+-} 6 HV, respectively. - Highlights: Black-Right-Pointing-Pointer DTA and microstructure of MAR-M247(Nb) showed a good agreement with Thermocalc. Black-Right-Pointing-Pointer An ideal condition for solution heat-treatment of MAR-M247(Nb) is 1260 Degree-Sign C for 8 h. Black-Right-Pointing-Pointer It was an observed evidence of incipient melting in samples heat-treated at 1280 Degree-Sign C.« less

  8. 7 CFR 247.24 - Recovery and redistribution of caseload and administrative funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Recovery and redistribution of caseload and...) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS COMMODITY SUPPLEMENTAL FOOD PROGRAM § 247.24 Recovery and redistribution of caseload and administrative funds. (a) May FNS...

  9. 48 CFR 247.573-1 - Ocean transportation incidental to a contract for supplies, services, or construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Business Management Directorate, MSC; or (ii) The Commander, Military Surface Deployment and Distribution... Commander, MSC, through the Contracts and Business Management Directorate, MSC; or (B) The Commander... MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-1 Ocean transportation incidental...

  10. 48 CFR 52.247-25 - Government-Furnished Equipment With or Without Operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... transportation or for transportation-related services when the Government furnishes equipment with or without... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Government-Furnished... Text of Provisions and Clauses 52.247-25 Government-Furnished Equipment With or Without Operators. As...

  11. 48 CFR 52.247-25 - Government-Furnished Equipment With or Without Operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... transportation or for transportation-related services when the Government furnishes equipment with or without... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Government-Furnished... Text of Provisions and Clauses 52.247-25 Government-Furnished Equipment With or Without Operators. As...

  12. 48 CFR 247.573-2 - Direct purchase of ocean transportation services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Direct purchase of ocean... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-2 Direct purchase of ocean transportation services. (a) This subsection applies when ocean...

  13. 48 CFR 247.573-2 - Direct purchase of ocean transportation services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Direct purchase of ocean... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-2 Direct purchase of ocean transportation services. (a) This subsection applies when ocean...

  14. 48 CFR 247.573-2 - Direct purchase of ocean transportation services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Direct purchase of ocean... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-2 Direct purchase of ocean transportation services. (a) This subsection applies when ocean...

  15. 48 CFR 247.573-2 - Direct purchase of ocean transportation services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Direct purchase of ocean... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-2 Direct purchase of ocean transportation services. (a) This subsection applies when ocean...

  16. 48 CFR 52.247-51 - Evaluation of Export Offers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Evaluation of Export....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision: Evaluation of Export Offers (JAN 2001) (a) Port handling and ocean charges—other than DOD water terminals...

  17. 48 CFR 52.247-12 - Supervision, Labor, or Materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Supervision, Labor, or....247-12 Supervision, Labor, or Materials. As prescribed in 47.207-5(b), insert a clause substantially... when the contractor is required to furnish supervision, labor, or materials: Supervision, Labor, or...

  18. 48 CFR 52.247-12 - Supervision, Labor, or Materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Supervision, Labor, or....247-12 Supervision, Labor, or Materials. As prescribed in 47.207-5(b), insert a clause substantially... when the contractor is required to furnish supervision, labor, or materials: Supervision, Labor, or...

  19. 48 CFR 52.247-12 - Supervision, Labor, or Materials.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Supervision, Labor, or....247-12 Supervision, Labor, or Materials. As prescribed in 47.207-5(b), insert a clause substantially... when the contractor is required to furnish supervision, labor, or materials: Supervision, Labor, or...

  20. 48 CFR 52.247-12 - Supervision, Labor, or Materials.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Supervision, Labor, or....247-12 Supervision, Labor, or Materials. As prescribed in 47.207-5(b), insert a clause substantially... when the contractor is required to furnish supervision, labor, or materials: Supervision, Labor, or...

  1. 48 CFR 52.247-12 - Supervision, Labor, or Materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Supervision, Labor, or....247-12 Supervision, Labor, or Materials. As prescribed in 47.207-5(b), insert a clause substantially... when the contractor is required to furnish supervision, labor, or materials: Supervision, Labor, or...

  2. 48 CFR 52.247-26 - Government Direction and Marking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Government Direction and....247-26 Government Direction and Marking. As prescribed in 47.207-8(a)(3), insert the following clause... relocations are involved: Government Direction and Marking (APR 1984) The agency being relocated shall tag or...

  3. 48 CFR 52.247-26 - Government Direction and Marking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Government Direction and....247-26 Government Direction and Marking. As prescribed in 47.207-8(a)(3), insert the following clause... relocations are involved: Government Direction and Marking (APR 1984) The agency being relocated shall tag or...

  4. 25 CFR 247.13 - Are the facilities available year around?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... tribe can contact the Area Director and ask that the sites be opened. The Area Director will work... RIVER TREATY FISHING ACCESS SITES § 247.13 Are the facilities available year around? (a) The Area... necessary. Before closing the facilities, the Area Director will consult with delegated tribal...

  5. Factors Affecting Middle School Students' Reading Motivation in Taiwan

    ERIC Educational Resources Information Center

    Huang, SuHua

    2013-01-01

    This study employed a triangulated mixed method to investigate reading motivation of Chinese middle school students in Taiwan. A total of 247 seventh grade students (122 boys and 125 girls) participated voluntarily by completing the Chinese Motivation for Research Questionnaire (CMRQ). Sixteen of the 247 students were purposely selected to…

  6. 14 CFR 125.247 - Inspection programs and maintenance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Maintenance § 125.247 Inspection programs and maintenance. (a) No person may operate an airplane subject to this part unless (1... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Inspection programs and maintenance. 125...

  7. 14 CFR 125.247 - Inspection programs and maintenance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Maintenance § 125.247 Inspection programs and maintenance. (a) No person may operate an airplane subject to this part unless (1... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Inspection programs and maintenance. 125...

  8. 14 CFR 125.247 - Inspection programs and maintenance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Maintenance § 125.247 Inspection programs and maintenance. (a) No person may operate an airplane subject to this part unless (1... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Inspection programs and maintenance. 125...

  9. 14 CFR 125.247 - Inspection programs and maintenance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Maintenance § 125.247 Inspection programs and maintenance. (a) No person may operate an airplane subject to this part unless (1... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Inspection programs and maintenance. 125...

  10. 14 CFR 125.247 - Inspection programs and maintenance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CAPACITY OF 6,000 POUNDS OR MORE; AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Maintenance § 125.247 Inspection programs and maintenance. (a) No person may operate an airplane subject to this part unless (1... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Inspection programs and maintenance. 125...

  11. 48 CFR 247.372 - DD Form 1654, Evaluation of Transportation Cost Factors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1654, Evaluation... Transportation in Supply Contracts 247.372 DD Form 1654, Evaluation of Transportation Cost Factors. Contracting personnel may use the DD Form 1654 to furnish information to the transportation office for development of...

  12. Performance Characteristics of Automotive Engines in the United States : First Series - Report No. 12 - 1975 Perkins Diesel 247 CID (4.0 Liters)

    DOT National Transportation Integrated Search

    1978-04-01

    Experimental data were obtained in dynamometer tests of a 1975 Perkins 247-CID diesel engine to determine fuel consumption and emissions (hydrocarbon, carbon monoxide, oxides of nitrogen) at steady-state engine-operating modes. The objective of the p...

  13. 48 CFR 247.573-1 - Ocean transportation incidental to a contract for supplies, services, or construction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Ocean transportation... MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-1 Ocean transportation incidental to a contract for supplies, services, or construction. (a) This subsection applies when ocean...

  14. 48 CFR 247.573-1 - Ocean transportation incidental to a contract for supplies, services, or construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Ocean transportation... MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-1 Ocean transportation incidental to a contract for supplies, services, or construction. (a) This subsection applies when ocean...

  15. 48 CFR 247.573-1 - Ocean transportation incidental to a contract for supplies, services, or construction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Ocean transportation... MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-1 Ocean transportation incidental to a contract for supplies, services, or construction. (a) This subsection applies when ocean...

  16. 48 CFR 247.573-1 - Ocean transportation incidental to a contract for supplies, services, or construction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Ocean transportation... MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 247.573-1 Ocean transportation incidental to a contract for supplies, services, or construction. (a) This subsection applies when ocean...

  17. 247. Axial Parkway alignment along ridge top. Note the open ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    247. Axial Parkway alignment along ridge top. Note the open vistas to either side of the roadway. These are maintained through vegetation management. The wood guide rail is a primary safety feature. View is to the northeast. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  18. Using Technology 24/7 for Regional Assistance after Shutdown of Major Industries

    ERIC Educational Resources Information Center

    Brinkman, Patricia; Hart, Melanie; Olinsky, Christine; Merkowitz, Rose Fisher

    2011-01-01

    People facing unemployment or who are underemployed need access to community and financial information and resources 24/7. Collaborating with community agencies and organizations, FCS educators developed a website with comprehensive local and state resources and educational tools that the consumer might otherwise not have been aware were…

  19. 40 CFR 761.247 - Sample site selection for pipe segment removal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.247 Sample site selection for pipe segment removal. (a) General. (1) Select the pipe... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sample site selection for pipe segment...

  20. 7 CFR 247.24 - Recovery and redistribution of caseload and administrative funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Recovery and redistribution of caseload and... FOOD PROGRAM § 247.24 Recovery and redistribution of caseload and administrative funds. (a) May FNS... agency must use 95 percent of its original caseload allocation to be eligible for additional caseload...

  1. 7 CFR 247.24 - Recovery and redistribution of caseload and administrative funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Recovery and redistribution of caseload and... FOOD PROGRAM § 247.24 Recovery and redistribution of caseload and administrative funds. (a) May FNS... agency must use 95 percent of its original caseload allocation to be eligible for additional caseload...

  2. 7 CFR 247.24 - Recovery and redistribution of caseload and administrative funds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Recovery and redistribution of caseload and... FOOD PROGRAM § 247.24 Recovery and redistribution of caseload and administrative funds. (a) May FNS... agency must use 95 percent of its original caseload allocation to be eligible for additional caseload...

  3. 16. Photographic copy of construction drawing, dated July 29, 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photographic copy of construction drawing, dated July 29, 1932, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2512, SDO 182 (VESTIBULE DETAILS) - Selfridge Field, Building Nos. 242, 247, 250, 242 & 247 Birch Street & 250 Wagner Street, Mount Clemens, Macomb County, MI

  4. 14. Photographic copy of construction drawing, dated July 29, 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photographic copy of construction drawing, dated July 29, 1932, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2513, SDO 183 (SECTIONS) - Selfridge Field, Building Nos. 242, 247, 250, 242 & 247 Birch Street & 250 Wagner Street, Mount Clemens, Macomb County, MI

  5. The Road to 24/7

    ERIC Educational Resources Information Center

    Briggs, Linda L.

    2006-01-01

    Wireless and mobile technologies are now everywhere, and 24/7 computing is as pervasive a term as the actual capability promises to be. Sometimes, in fact, the push toward mobile technologies can seem overwhelming. But every wireless project doesn't have to involve redesigning the network and investing in mega-dollars worth of hardware and…

  6. Management of Library Security. SPEC Kit 247 and SPEC Flyer 247.

    ERIC Educational Resources Information Center

    Soete, George J., Comp.; Zimmerman, Glen, Comp.

    This SPEC (Systems and Procedures Exchange Center) Kit and Flyer reports results of a survey conducted in January 1999 that examined how ARL (Association of Research Libraries) member libraries assure the safety and security of persons, library materials, physical facilities, furnishings, computer equipment, etc. Forty-five of the 122 ARL member…

  7. 48 CFR 52.247-10 - Net Weight-General Freight.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... weighmaster on a certified scale) from the gross weight of the vehicle (determined by having the loaded... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Net Weight-General Freight....247-10 Net Weight—General Freight. As prescribed in 47.207-4(a)(2), insert the following clause in...

  8. 40 CFR 761.247 - Sample site selection for pipe segment removal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Sample site selection for pipe segment... Natural Gas Pipeline: Selecting Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.247 Sample site selection for pipe segment removal. (a) General. (1) Select the pipe...

  9. 32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

  10. 32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

  11. 32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

  12. 32 CFR Appendix E to Part 247 - DoD Command Newspaper and Magazine Review System

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false DoD Command Newspaper and Magazine Review System E Appendix E to Part 247 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN...

  13. Deceleration lights on trucks : a report to the governor and General Assembly of Virginia in response to Senate Joint Resolution no. 247, 1993 legislative session.

    DOT National Transportation Integrated Search

    1994-01-01

    Senate Joint Resolution No. 247, 1993 Session, requested that the Virginia Department of Motor Vehicles, the Center for Innovative Technology, the Motor Carrier Division of the State Corporation Commission, and the Department of State Police conduct ...

  14. Development and Pilot Testing of 24/7 In-Ambulance Telemedicine for Acute Stroke: Prehospital Stroke Study at the Universitair Ziekenhuis Brussel-Project.

    PubMed

    Valenzuela Espinoza, Alexis; Van Hooff, Robbert-Jan; De Smedt, Ann; Moens, Maarten; Yperzeele, Laetitia; Nieboer, Koenraad; Hubloue, Ives; de Keyser, Jacques; Convents, Andre; Fernandez Tellez, Helio; Dupont, Alain; Putman, Koen; Brouns, Raf

    2016-01-01

    In-ambulance telemedicine is a recently developed and a promising approach to improve emergency care. We implemented the first ever 24/7 in-ambulance telemedicine service for acute stroke. We report on our experiences with the development and pilot testing of the Prehospital Stroke Study at the Universitair Ziekenhuis Brussel (PreSSUB) to facilitate a wider spread of the knowledge regarding this technique. Successful execution of the project involved the development and validation of a novel stroke scale, design and creation of specific hardware and software solutions, execution of field tests for mobile internet connectivity, design of new care processes and information flows, recurrent training of all professional caregivers involved in acute stroke management, extensive testing on healthy volunteers, organisation of a 24/7 teleconsultation service by trained stroke experts and 24/7 technical support, and resolution of several legal issues. In all, it took 41 months of research and development to confirm the safety, technical feasibility, reliability, and user acceptance of the PreSSUB approach. Stroke-specific key information can be collected safely and reliably before and during ambulance transportation and can adequately be communicated with the inhospital team awaiting the patient. This paper portrays the key steps required and the lessons learned for successful implementation of a 24/7 expert telemedicine service supporting patients with acute stroke during ambulance transportation to the hospital. © 2016 S. Karger AG, Basel.

  15. US Food and Drug Administration Clearance of Moderate-Risk Otolaryngologic Devices via the 510(k) Process, 1997-2016.

    PubMed

    Rathi, Vinay K; Gadkaree, Shekhar K; Ross, Joseph S; Kozin, Elliott D; Sethi, Rosh K; Naunheim, Matthew R; Puram, Sidharth V; Gray, Stacey T

    2017-10-01

    Objective The US Food and Drug Administration (FDA) clears moderate-risk devices via the 510(k) process based on substantial equivalence to previously cleared devices; evidence of safety and effectiveness is not required. We characterized the premarket evidence supporting FDA clearance of otolaryngologic devices. Study Design Retrospective cross-sectional analysis. Setting Publicly available FDA documents. Subjects and Methods Recently cleared (1997-2016) moderate-risk otolaryngologic devices were categorized by type (diagnostic/therapeutic), subspecialty, implantable designation (yes/no), and recall history (yes/no). Supporting evidence was categorized by type (clinical/nonclinical/none; nonclinical and clinical mutually inclusive) and public availability of nonclinical and clinical performance data (available/not provided/not applicable). Results Between 1997 and 2016, the FDA cleared 377 moderate-risk otolaryngologic devices. The majority were therapeutic (n = 240/377 [63.7%]) and otologic (n = 311/377 [82.5%]); roughly one-third (n = 121/377 [32.1%]) were implantable. Few (n = 10/377 [2.7%]) devices were subject to recall. FDA documents summarizing premarket evidence were accessible for two-thirds (n = 247/377 [65.5%]) of devices. Among these devices, one-quarter (n = 66/247 [26.7%]) were supported by clinical evidence. The majority (n = 177/247 [71.7%]) were supported by nonclinical evidence, although nearly one-quarter (n = 58/247 [23.5%]) were cleared without supporting evidence. Therapeutic devices were more often cleared without supporting evidence (therapeutic: n = 53/170 [31.2%]; diagnostic: n = 5/77 [6.5%]; P < .0001). Nonclinical and clinical performance data were rarely available (nonclinical: n = 49/247 [19.8%]; clinical: n = 32/247 [13.0%]) within public summaries. Conclusion The FDA cleared most moderate-risk otolaryngologic devices for marketing via the 510(k) process without clinical evidence of safety and effectiveness. Otolaryngologists should be aware of limitations in premarket evidence when considering the adoption of new devices into clinical practice.

  16. New OPTN/UNOS classification system for nodules in cirrhotic livers detected with MR imaging: effect on hepatocellular carcinoma detection and transplantation allocation.

    PubMed

    Rosenkrantz, Andrew B; Campbell, Naomi; Wehrli, Natasha; Triolo, Michael J; Kim, Sooah

    2015-02-01

    To assess the effect of the new Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) policy on hepatocellular carcinoma (HCC) detection and liver transplant allocation in patients with cirrhosis undergoing dynamic contrast material-enhanced liver magnetic resonance (MR) imaging. In this HIPAA-compliant institutional review board-approved retrospective study with waiver of informed consent, 247 patients (196 men, 51 women; mean age, 60 years ± 11 [standard deviation]) with liver cirrhosis who underwent evaluation for HCC with MR imaging were identified via database search. Three radiologists independently reviewed images and identified number and size of HCC based on criteria within either the prior or revised policy. Based on these interpretations, priority for liver transplantation for each patient was determined with prior and revised transplantation allocation criteria. HCC detection was compared between sessions by using McNemar tests, and interreader agreement for detection of at least one HCC was assessed by using κ coefficients. All three readers detected significantly more 1-2-cm HCCs with the revised policy (readers detected 22, eight, and 20 1-2-cm HCCs) versus the prior policy (no reader detected 1-2-cm HCCs) (P ≤ .031). All readers detected significantly fewer 2-5-cm HCCs with the revised policy (readers detected eight, 13, and 14 2-5-cm HCCs) versus the prior policy (readers detected 24, 21, and 24 2-5-cm HCCs) (P ≤ .027). For all readers, fewer patients met criteria for increased transplantation priority with the revised versus the prior policy (number of patients who received increased priority for the three readers were 4.9% [12 of 247] vs 9.3% [23 of 247]; 5.7% [14 of 247] vs 8.1% [20 of 247]; and 6.9% [17 of 247] vs 8.9% [22 of 247]). Interreader agreement was substantial for the prior policy (κ = 0.607) and almost perfect for the revised policy (κ = 0.813). Among cirrhotic patients who underwent evaluation for HCC with MR imaging, the revised OPTN/UNOS policy led to increased detection of 1-2-cm HCCs, decreased detection of 2-5-cm HCCs, and fewer patients who met criteria for increased transplant priority. © RSNA, 2014.

  17. Nucleotide sequence analysis establishes the role of endogenous murine leukemia virus DNA segments in formation of recombinant mink cell focus-forming murine leukemia viruses.

    PubMed Central

    Khan, A S

    1984-01-01

    The sequence of 363 nucleotides near the 3' end of the pol gene and 564 nucleotides from the 5' terminus of the env gene in an endogenous murine leukemia viral (MuLV) DNA segment, cloned from AKR/J mouse DNA and designated as A-12, was obtained. For comparison, the nucleotide sequence in an analogous portion of AKR mink cell focus-forming (MCF) 247 MuLV provirus was also determined. Sequence features unique to MCF247 MuLV DNA in the 3' pol and 5' env regions were identified by comparison with nucleotide sequences in analogous regions of NFS -Th-1 xenotropic and AKR ecotropic MuLV proviruses. These included (i) an insertion of 12 base pairs encoding four amino acids located 60 base pairs from the 3' terminus of the pol gene and immediately preceding the env gene, (ii) the deletion of 12 base pairs (encoding four amino acids) and the insertion of 3 base pairs (encoding one amino acid) in the 5' portion of the env gene, and (iii) single base substitutions resulting in 2 MCF247 -specific amino acids in the 3' pol and 23 in the 5' env regions. Nucleotide sequence comparison involving the 3' pol and 5' env regions of AKR MCF247 , NFS xenotropic, and AKR ecotropic MuLV proviruses with the cloned endogenous MuLV DNA indicated that MCF247 proviral DNA sequences were conserved in the cloned endogenous MuLV proviral segment. In fact, total nucleotide sequence identity existed between the endogenous MuLV DNA and the MCF247 MuLV provirus in the 3' portion of the pol gene. In the 5' env region, only 4 of 564 nucleotides were different, resulting in three amino acid changes between AKR MCF247 MuLV DNA and the endogenous MuLV DNA present in clone A-12. In addition, nucleotide sequence comparison indicated that Moloney-and Friend-MCF MuLVs were also highly related in the 3' pol and 5' env regions to the cloned endogenous MuLV DNA. These results establish the role of endogenous MuLV DNA segments in generation of recombinant MCF viruses. PMID:6328017

  18. 25 CFR 1000.247 - May the Secretary require design provisions and other terms and conditions for construction...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false May the Secretary require design provisions and other..., DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.247 May the Secretary require design...

  19. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    -486-6999 Urgent Radiation Protection Group Assistance Non-Life Threatening Event 24/7 Lab Phone: x7277 : 911 (no extentions required now) Non-Emergency Reporting (Fire and Police) Non-Life Threatening Event Spill Non-Life Threatening Event 24/7 Lab Phone: x6999 Cell Phone: 510-486-6999 Off Site Locations: 510

  20. 48 CFR 538.7103 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... limited to— (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  1. 48 CFR 538.7103 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... limited to— (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  2. 48 CFR 538.7003 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... limited to: (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  3. 48 CFR 538.7103 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... limited to— (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  4. 48 CFR 538.7003 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... limited to: (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  5. 48 CFR 538.7003 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... limited to: (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  6. 48 CFR 538.7003 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... limited to: (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  7. 48 CFR 538.7103 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... limited to— (a) 52.212-4, Contract Terms and Conditions—Commercial Items. (b) 52.216-18, Ordering. (c) 52.216-19, Order Limitations. (d) 52.229-1, State and Local Taxes. (e) 52.229-3, Federal, State, and..., Inspection-Time-and-Material and Labor-Hour. (n) 52.247-34, F.O.B. Destination. (o) 52.247-38, F.O.B. Inland...

  8. 15. Photographic copy of construction drawing, dated June 7, 1933, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Photographic copy of construction drawing, dated June 7, 1933, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-25??, SDO 134 F4 1B (ELEVATIONS) - Selfridge Field, Building Nos. 242, 247, 250, 242 & 247 Birch Street & 250 Wagner Street, Mount Clemens, Macomb County, MI

  9. 40 CFR 174.524 - Glyphosate Oxidoreductase GOX or GOXv247 in all plants; exemption from the requirement of a...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Glyphosate Oxidoreductase GOX or... REQUIREMENTS FOR PLANT-INCORPORATED PROTECTANTS Tolerances and Tolerance Exemptions § 174.524 Glyphosate... Glyphosate Oxidoreductase GOX or GOXv247 enzyme in all plants are exempt from the requirement of a tolerance...

  10. 40 CFR 174.524 - Glyphosate Oxidoreductase GOX or GOXv247 in all plants; exemption from the requirement of a...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Glyphosate Oxidoreductase GOX or... REQUIREMENTS FOR PLANT-INCORPORATED PROTECTANTS Tolerances and Tolerance Exemptions § 174.524 Glyphosate... Glyphosate Oxidoreductase GOX or GOXv247 enzyme in all plants are exempt from the requirement of a tolerance...

  11. 40 CFR 174.524 - Glyphosate Oxidoreductase GOX or GOXv247 in all plants; exemption from the requirement of a...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Glyphosate Oxidoreductase GOX or... REQUIREMENTS FOR PLANT-INCORPORATED PROTECTANTS Tolerances and Tolerance Exemptions § 174.524 Glyphosate... Glyphosate Oxidoreductase GOX or GOXv247 enzyme in all plants are exempt from the requirement of a tolerance...

  12. 40 CFR 174.524 - Glyphosate Oxidoreductase GOX or GOXv247 in all plants; exemption from the requirement of a...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Glyphosate Oxidoreductase GOX or... REQUIREMENTS FOR PLANT-INCORPORATED PROTECTANTS Tolerances and Tolerance Exemptions § 174.524 Glyphosate... Glyphosate Oxidoreductase GOX or GOXv247 enzyme in all plants are exempt from the requirement of a tolerance...

  13. 40 CFR 174.524 - Glyphosate Oxidoreductase GOX or GOXv247 in all plants; exemption from the requirement of a...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Glyphosate Oxidoreductase GOX or... REQUIREMENTS FOR PLANT-INCORPORATED PROTECTANTS Tolerances and Tolerance Exemptions § 174.524 Glyphosate... Glyphosate Oxidoreductase GOX or GOXv247 enzyme in all plants are exempt from the requirement of a tolerance...

  14. 75 FR 62333 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ...., Monday through Friday, except Federal holidays. The AD docket contains this proposed AD, the regulatory... that the 247F propeller blades, P/N 817370-1, S/Ns FR2449 to FR2958 inclusive, FR20010710 to FR20010722 inclusive, and FR20010723RT to FR20020127RT inclusive, manufactured since January 1999, might also have...

  15. 7 CFR 247.13 - Provisions for non-English or limited-English speakers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Provisions for non-English or limited-English speakers... § 247.13 Provisions for non-English or limited-English speakers. (a) What must State and local agencies do to ensure that non-English or limited-English speaking persons are aware of their rights and...

  16. 48 CFR 52.247-35 - F.o.b. Destination, Within Consignee's Premises.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Destination, Within... Clauses 52.247-35 F.o.b. Destination, Within Consignee's Premises. As prescribed in 47.303-7(c), insert the following clause in solicitations and contracts when the delivery term is f.o.b. destination...

  17. 48 CFR 52.247-47 - Evaluation-F.o.b. Origin.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Evaluation-F.o.b. Origin....247-47 Evaluation—F.o.b. Origin. As prescribed in 47.305-3(f)(2), insert the following provision. When..., pipeline, barge, or ocean tanker, modify the provision accordingly. Evaluation—F.o.b. Origin (JUN 2003) (a...

  18. 48 CFR 52.247-34 - F.o.b. Destination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Destination. 52.247....o.b. Destination. As prescribed in 47.303-6(c), insert the following clause: F.o.b. Destination (JAN 1991) (a) The term f.o.b. destination, as used in this clause, means— (1) Free of expense to the...

  19. 48 CFR 3052.247-72 - F.o.b. destination only.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false F.o.b. destination only... CLAUSES Text of Provisions and Clauses 3052.247-72 F.o.b. destination only. As prescribed in (HSAR) 48 CFR 3047.305-70(c), insert the following provision: F.O.B. Destination Only (DEC 2003) Offers are invited...

  20. 48 CFR 3052.247-70 - F.o.b. origin information.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false F.o.b. origin information... CLAUSES Text of Provisions and Clauses 3052.247-70 F.o.b. origin information. As prescribed in (HSAR) 48 CFR 3047.305-70(a), insert the following provision: F.O.B. Origin Information (DEC 2003) The offeror...

  1. 48 CFR 52.247-30 - F.o.b. Origin, Contractor's Facility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin, Contractor... Clauses 52.247-30 F.o.b. Origin, Contractor's Facility. As prescribed in 47.303-2(c), insert the following clause in solicitations and contracts when the delivery term is f.o.b. origin, contractor's facility: F.o...

  2. 48 CFR 52.247-48 - F.o.b. Destination-Evidence of Shipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Destination... Provisions and Clauses 52.247-48 F.o.b. Destination—Evidence of Shipment. As prescribed in 47.305-4(c), insert the following clause: F.o.b. Destination—Evidence of Shipment (FEB 1999) (a) If this contract is...

  3. Creep-Fatigue Cracking Near the Welded Interface in Friction Welding Dissimilar Superalloys INCONEL 718 and MAR-M247

    NASA Astrophysics Data System (ADS)

    Tra, Tran Hung; Okazaki, Masakazu

    2017-08-01

    A forged INCONEL 718 and a cast MAR-M247 alloy were joined by a friction welding process. The creep-fatigue strength of this joint was investigated. The life of the joint was significantly shorter than that of the base alloys. The joint failed near the interface of the INCONEL 718 side, although the life of INCONEL 718 was longer than that of MAR-M247. To understand this behavior, the stress field in the welding was numerically analyzed using a visco-elastic model. The results suggested that triaxiality in the stress state could be promoted near the welded interface and lead to an acceleration of creep-fatigue crack nucleation.

  4. The effect of tantalum on the structure/properties of two polycrystalline nickel-base superalloys: B-1900 + Hf MAR-M247. M.S. Thesis, Final Report

    NASA Technical Reports Server (NTRS)

    Janowski, G. M.

    1985-01-01

    The microstructure, phase compositions, and phase fractions were studied in conventionally cast B-1900 + Hf and both conventionally cast and directionally solidified MAR-M247 as a function of tantalum concentration. The hot tensile and creep rupture properties of the solutionized and aged MAR-M247-type alloys were also determined as a function of tantalum level. The effects of tantalum on the microstructure and phase compositions of B-1900 + Hf and MAR-M247 (conventionally cast and directionally solidified) were found to be very similar. The addition of tantalum to the as cast and heat treated alloys was shown to cause the partial replacement of the Hf in the MC carbides by Ta, although the degree of replacement was decreased by the solutionizing and aging heat treatment. The gamma prime and minor phase fractions (primarily MC type carbides) both increased approximately linearly with tantalum concentration. The gamma prime phase compositions were relatively insensitive to tantalum variations with the exception of the tantalum and/or hafnium levels. Bulk tantalum additions increased the tantalum, chromium, and cobalt levels of the gamma phase in both alloy series. The increase in the concentrations of the latter two elements in the gamma phase was a result of the decrease in the gamma phase fraction with increasing bulk tantalum concentration and constant gamma/gamma prime partitioning ratio. Tantalum additions increased the yield stress and ultimate tensile strength of the directionally solidified MAR-M247 type alloys and had no significant effect on ductility.

  5. 75 FR 35838 - Controlled Substances: Proposed Revised Aggregate Production Quotas for 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ...,000,000 g Amphetamine (for conversion) 6,500,000 g 6,500,000 g Cocaine 247,000 g 247,000 g Codeine... Fairness Act of 1996 (Congressional Review Act). This action will not result in an annual effect on the economy of $100,000,000 or more; a major increase in costs or prices; or significant adverse effects on...

  6. 48 CFR 52.247-31 - F.o.b. Origin, Freight Allowed.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false F.o.b. Origin, Freight....247-31 F.o.b. Origin, Freight Allowed. As prescribed in 47.303-3(c), insert the following clause: F.o.b. Origin, Freight Allowed (FEB 2006) (a) The term f.o.b. origin, freight allowed, as used in this...

  7. 48 CFR 52.247-32 - F.o.b. Origin, Freight Prepaid.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false F.o.b. Origin, Freight....247-32 F.o.b. Origin, Freight Prepaid. As prescribed in 47.303-4(c), insert the following clause: F.o.b. Origin, Freight Prepaid (FEB 2006) (a) The term f.o.b. origin, freight prepaid, as used in this...

  8. 48 CFR 52.247-31 - F.o.b. Origin, Freight Allowed.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false F.o.b. Origin, Freight....247-31 F.o.b. Origin, Freight Allowed. As prescribed in 47.303-3(c), insert the following clause: F.o.b. Origin, Freight Allowed (FEB 2006) (a) The term f.o.b. origin, freight allowed, as used in this...

  9. 48 CFR 52.247-32 - F.o.b. Origin, Freight Prepaid.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false F.o.b. Origin, Freight....247-32 F.o.b. Origin, Freight Prepaid. As prescribed in 47.303-4(c), insert the following clause: F.o.b. Origin, Freight Prepaid (FEB 2006) (a) The term f.o.b. origin, freight prepaid, as used in this...

  10. 48 CFR 52.247-31 - F.o.b. Origin, Freight Allowed.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false F.o.b. Origin, Freight....247-31 F.o.b. Origin, Freight Allowed. As prescribed in 47.303-3(c), insert the following clause: F.o.b. Origin, Freight Allowed (FEB 2006) (a) The term f.o.b. origin, freight allowed, as used in this...

  11. 48 CFR 52.247-32 - F.o.b. Origin, Freight Prepaid.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false F.o.b. Origin, Freight....247-32 F.o.b. Origin, Freight Prepaid. As prescribed in 47.303-4(c), insert the following clause: F.o.b. Origin, Freight Prepaid (FEB 2006) (a) The term f.o.b. origin, freight prepaid, as used in this...

  12. 48 CFR 52.247-31 - F.o.b. Origin, Freight Allowed.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false F.o.b. Origin, Freight....247-31 F.o.b. Origin, Freight Allowed. As prescribed in 47.303-3(c), insert the following clause: F.o.b. Origin, Freight Allowed (FEB 2006) (a) The term f.o.b. origin, freight allowed, as used in this...

  13. 48 CFR 52.247-32 - F.o.b. Origin, Freight Prepaid.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false F.o.b. Origin, Freight....247-32 F.o.b. Origin, Freight Prepaid. As prescribed in 47.303-4(c), insert the following clause: F.o.b. Origin, Freight Prepaid (FEB 2006) (a) The term f.o.b. origin, freight prepaid, as used in this...

  14. 48 CFR 52.247-44 - F.o.b. Designated Air Carrier's Terminal, Point of Importation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Designated Air... CLAUSES Text of Provisions and Clauses 52.247-44 F.o.b. Designated Air Carrier's Terminal, Point of... the delivery term is f.o.b. designated air carrier's terminal, point of importation: F.o.b. Designated...

  15. 48 CFR 3052.247-71 - F.o.b. origin only.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false F.o.b. origin only. 3052... CLAUSES Text of Provisions and Clauses 3052.247-71 F.o.b. origin only. As prescribed in (HSAR) 48 CFR 3047.305-70(b), insert the following provision: F.O.B. Origin Only (DEC 2003) Offers are invited on the...

  16. 48 CFR 52.247-29 - F.o.b. Origin.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin. 52.247-29....o.b. Origin. As prescribed in 47.303-1(c), insert the following clause: F.o.b. Origin (FEB 2006) (a) The term f.o.b. origin, as used in this clause, means free of expense to the Government delivered— (1...

  17. 48 CFR 52.247-65 - F.o.b. Origin, Prepaid Freight-Small Package Shipments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin, Prepaid... Text of Provisions and Clauses 52.247-65 F.o.b. Origin, Prepaid Freight—Small Package Shipments. As prescribed in 47.303-17(f), insert the following clause: F.o.b. Origin Prepaid Freight—Small Package...

  18. 48 CFR 52.247-38 - F.o.b. Inland Carrier, Point of Exportation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Inland Carrier... Provisions and Clauses 52.247-38 F.o.b. Inland Carrier, Point of Exportation. As prescribed in 47.303-10(c), insert the following clause in solicitations and contracts when the delivery term is f.o.b. inland...

  19. 48 CFR 52.247-61 - F.o.b. Origin-Minimum Size of Shipments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin-Minimum Size... Clauses 52.247-61 F.o.b. Origin—Minimum Size of Shipments. As prescribed in 47.305-16(c), insert the following clause in solicitations and contracts when volume rates may apply: F.o.b. Origin—Minimum Size of...

  20. 48 CFR 52.247-43 - F.o.b. Designated Air Carrier's Terminal, Point of Exportation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Designated Air... CLAUSES Text of Provisions and Clauses 52.247-43 F.o.b. Designated Air Carrier's Terminal, Point of... the delivery term is f.o.b. designated air carrier's terminal, point of exportation: F.o.b. Designated...

  1. 48 CFR 52.247-32 - F.o.b. Origin, Freight Prepaid.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin, Freight....247-32 F.o.b. Origin, Freight Prepaid. As prescribed in 47.303-4(c), insert the following clause: F.o.b. Origin, Freight Prepaid (FEB 2006) (a) The term f.o.b. origin, freight prepaid, as used in this...

  2. 48 CFR 52.247-31 - F.o.b. Origin, Freight Allowed.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin, Freight....247-31 F.o.b. Origin, Freight Allowed. As prescribed in 47.303-3(c), insert the following clause: F.o.b. Origin, Freight Allowed (FEB 2006) (a) The term f.o.b. origin, freight allowed, as used in this...

  3. 48 CFR 52.247-59 - F.o.b. Origin-Carload and Truckload Shipments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin-Carload and... Clauses 52.247-59 F.o.b. Origin—Carload and Truckload Shipments. As prescribed in 47.305-16(a), insert the following clause in solicitations and contracts when it is contemplated that they may result in f.o.b...

  4. 48 CFR 52.247-39 - F.o.b. Inland Point, Country of Importation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Inland Point... Provisions and Clauses 52.247-39 F.o.b. Inland Point, Country of Importation. As prescribed in 47.303-11(c), insert the following clause in solicitations and contracts when the delivery term is f.o.b. inland point...

  5. Susceptibility of three laboratory strains of Anopheles albimanus (Diptera: Culicidae) to coindigenous Plasmodium vivax circumsporozoite protein phenotypes in southern Mexico.

    PubMed

    Gonzalez-Ceron, L; Rodriguez, M H; Santillan, F V; Hernandez, J E; Wirtz, R A

    2000-05-01

    The susceptibility to two coindigenous Plasmodium vivax Grassi & Feletti phenotypes VK210 and VK247 of three colonized Anopheles albimanus Wiedemann strains (white-striped, green and brown) from southern Mexico was investigated. Mosquitoes of the three strains were simultaneously fed with P. vivax-infected patient blood and examined 1 wk later for the presence of oocysts. The circumsporozoite protein phenotype type (VK210 and VK247) was determined by immunoflorescence of salivary gland sporozoites using monoclonal antibodies. The proportions of specimens infected and the number of oocyst per mosquito indicated that all mosquito strains were more susceptible to the phenotype VK210 than to VK247, but the white-striped strain was more susceptible to both parasite phenotypes than the other two strains.

  6. Survival of modern knee tumor megaprostheses: failures, functional results, and a comparative statistical analysis.

    PubMed

    Pala, Elisa; Trovarelli, Giulia; Calabrò, Teresa; Angelini, Andrea; Abati, Caterina N; Ruggieri, Pietro

    2015-03-01

    Modular megaprostheses are now the most common method of reconstruction after segmental resection of the long bones in the lower extremities. Previous studies reported variable outcome and failure rates after knee megaprosthetic reconstructions. The objectives of this study were to analyze the results of a modular tumor prosthesis after resection of bone tumor around the knee with respect to (1) survivorship; (2) failure rate; (3) comparative survivorship against different sites of reconstructions and of primary and revision implants; and (4) functional results on the Musculoskeletal Tumor Society (MSTS) scoring system. Between 2003 and 2010, 247 rotating-hinge Global Modular Reconstruction System (GMRS) knee prostheses were implanted in our institute for malignant and aggressive benign tumors. During this time, that group represented 23% of the patients who had oncologic megaprosthesis reconstruction about the knee after resection of primary or metastatic bone tumors (247 of 1086 patients). In the other 77% of cases we used other types of oncologic prostheses. Before 2003 we used the older Howmedica Modular Resection System and Kotz Modular Femur/Tibia Replacement from 2003 we used mostly the GMRS but we continued to use the HMRS in some cases such as patients with poor prognoses, elderly patients, or metastatic patients. Sites included 187 distal femurs and 60 proximal tibias. Causes of megaprosthesis failure were classified according to Henderson et al. in five types: Type 1 (soft tissue failure), Type 2 (aseptic loosening), Type 3 (structural failure), Type 4 (infection), and Type 5 (tumor progression). Followup was at a minimum oncologic followup of 2 years (mean, 4 years; range, 2-8 years). Kaplan-Meier actuarial curves of implant survival to major failures were done. Functional results were analyzed according to the MSTS II system; 223 of the 247 were available for functional scoring (81%). At latest followup, among 175 treated patients for primary reconstruction, 117 are continuously disease-free, 26 have no evidence of disease after treatment of relapse, eight are alive with disease, and 24 died from disease. The overall failure rate of the megaprostheses in our series was 29.1% (72 of 247). Type 1 failure occurred in 8.5% (21 of 247) cases, Type 2 in 5.6% (14 of 247), Type 3 in 0%, Type 4 in 9.3% (23 of 247), and Type 5 in 5.6% (14 of 247). Kaplan-Meier curve showed an overall implant survival rate for all types of failures of 70% at 4 years and 58% at 8 years. Prosthetic survivorship for revisions was 80% at 5 years and for primary reconstructions was 60% at 5 years (p = 0.013). Survivorship to infection was 95% at 5 years for revision patients and 84% at 5 years for primary patients (p = 0.475). The mean MSTS score was 84 (25.2; range, 8-30) with no difference between sites of localization (24.7 in proximal tibia versus 25.4 in distal femur reconstruction; p = 0.306). Results at a minimum of 2 years with this modular prosthesis are satisfactory in terms of survivorship (both oncologic and reconstructive) and causes and rates of failure. Although these results seem comparable with other like implants, we will continue to follow this cohort, and we believe that comparative trials among the available megaprosthesis designs are called for. Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

  7. 247. Photocopied July 1978. (QMC) SEARSROEBUCK & CO., FURNISHED DRAWING, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    247. Photocopied July 1978. (QMC) SEARS-ROEBUCK & CO., FURNISHED DRAWING, FRONT AND SIDE ELEVATIONS, 6-15-17, SHEET #1 OF 3. FORTY HOUSES OF THIS TYPE WERE BUILT IN 1917:9 AT MESNARD, 19 AT LOWER PEWABIC, 3 AT PEWABIC, 2 AT LIMERICK, 3 AT FRENCHTOWN, 3 AT THE SIDE-HILL ADDITION, 1 AT SING-SING. QMC SINGLE HOUSES. - Quincy Mining Company, Hancock, Houghton County, MI

  8. 48 CFR 52.247-37 - F.o.b. Vessel, Port of Shipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Vessel, Port of....247-37 F.o.b. Vessel, Port of Shipment. As prescribed in 47.303-9(c), insert the following clause in solicitations and contracts when the delivery term is f.o.b. vessel, port of shipment: F.o.b. Vessel, Port of...

  9. 48 CFR 52.247-55 - F.o.b. Point for Delivery of Government-Furnished Property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Point for Delivery... Text of Provisions and Clauses 52.247-55 F.o.b. Point for Delivery of Government-Furnished Property. As prescribed in 47.305-12(a)(2), insert the following clause: F.o.b. Point for Delivery of Government-Furnished...

  10. Help at 3:00 AM! Providing 24/7 Timely Support to Online Students via a Virtual Assistant

    ERIC Educational Resources Information Center

    Vu, Phu; Fredrickson, Scott; Meyer, Richard

    2016-01-01

    With a dearth of research on human-robot interaction in education and relatively high non-completion rates of online students, this study was conducted to determine the feasibility of using a virtual assistant (VA) to respond to questions and concerns of students and provide 24/7 online course content support. During a 16 week-long academic…

  11. Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.

    PubMed

    Martins, M; Williams, A H; Comeau, M; Marion, M; Ziegler, J T; Freedman, B I; Merrill, J T; Glenn, S B; Kelly, J A; Sivils, K M; James, J A; Guthridge, J M; Alarcón-Riquelme, M E; Bae, S-C; Kim, J-H; Kim, D; Anaya, J-M; Boackle, S A; Criswell, L A; Kimberly, R P; Alarcón, G S; Brown, E E; Vilá, L M; Petri, M A; Ramsey-Goldman, R; Niewold, T B; Tsao, B P; Gilkeson, G S; Kamen, D L; Jacob, C O; Stevens, A M; Gaffney, P M; Harley, J B; Langefeld, C D; Fesel, C

    2015-03-01

    A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multiethnic population. We typed 44 contiguous CD247 single-nucleotide polymorphisms (SNPs) in 8922 SLE patients and 8077 controls from four ethnically distinct populations. The strongest associations were found in the Asian population (11 SNPs in intron 1, 4.99 × 10(-4) < P < 4.15 × 10(-2)), where we further identified a five-marker haplotype (rs12141731-rs2949655-rs16859085-rs12144621-rs858554; G-G-A-G-A; P(hap) = 2.12 × 10(-5)) that exceeded the most associated single SNP rs858554 (minor allele frequency in controls = 13%; P = 4.99 × 10(-4), odds ratio = 1.32) in significance. Imputation and subsequent association analysis showed evidence of association (P < 0.05) at 27 additional SNPs within intron 1. Cross-ethnic meta-analysis, assuming an additive genetic model adjusted for population proportions, showed five SNPs with significant P-values (1.40 × 10(-3) < P< 3.97 × 10(-2)), with one (rs704848) remaining significant after Bonferroni correction (P(meta) = 2.66 × 10(-2)). Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.

  12. Plasmodium vivax: ookinete destruction and oocyst development arrest are responsible for Anopheles albimanus resistance to circumsporozoite phenotype VK247 parasites.

    PubMed

    Gonzalez-Ceron, L; Rodriguez, M H; Santillan, F; Chavez, B; Nettel, J A; Hernandez-Avila, J E; Kain, K C

    2001-07-01

    Anopheles albimanus and An. pseudopunctipennis differ in their susceptibilities to Plasmodium vivax circumsporozoite phenotypes. An. pseudopunctipennis is susceptible to phenotype VK247 but almost refractory to VK210. In contrast, An. albimanus is almost refractory to VK247 but susceptible to VK210. To investigate the site in the mosquito and the parasite stage at which resistance mechanisms affect VK247 development in An. albimanus, parasite development was followed in a series of experiments in which both mosquitoes species were simultaneously infected with blood from patients. Parasite phenotype was determined in mature oocysts and salivary gland sporozoites by use of immunofluorescence and Western blot assays and/or gene identification. Ookinete maturation and their densities within the bloodmeal bolus were similar in both mosquito species. Ookinete densities on the internal midgut surface of An. albimanus were 4.7 times higher than those in An. pseudopunctipennis; however, the densities of developing oocysts on the external midgut surface were 6.12 times higher in the latter species. Electron microscopy observation of ookinetes in An. albimanus midgut epithelium indicated severe parasite damage. These results indicate that P. vivax VK247 parasites are destroyed at different parasite stages during migration in An. albimanus midguts. A portion, accumulated on the internal midgut surface, is probably destroyed by the mosquito's digestive enzymes and another portion is most likely destroyed by mosquito defense molecules within the midgut epithelium. A third group, reaching the external midgut surface, initiates oocyst development, but over 90% of them interrupt their development and die. The identification of mechanisms that participate in parasite destruction could provide new elements to construct transgenic mosquitoes resistant to malaria parasites. Copyright 2001 Academic Press.

  13. Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains

    PubMed Central

    Palma, Eleonora; Fucile, Sergio; Barabino, Benedetta; Miledi, Ricardo; Eusebi, Fabrizio

    1999-01-01

    Recent work has shown that strychnine, the potent and selective antagonist of glycine receptors, is also an antagonist of nicotinic acetylcholine (AcCho) receptors including neuronal homomeric α7 receptors, and that mutating Leu-247 of the α7 nicotinic AcCho receptor-channel domain (L247Tα7; mut1) converts some nicotinic antagonists into agonists. Therefore, a study was made of the effects of strychnine on Xenopus oocytes expressing the chick wild-type α7 or L247Tα7 receptors. In these oocytes, strychnine itself did not elicit appreciable membrane currents but reduced the currents elicited by AcCho in a reversible and dose-dependent manner. In sharp contrast, in oocytes expressing L247Tα7 receptors with additional mutations at Cys-189 and Cys-190, in the extracellular N-terminal domain (L247T/C189–190Sα7; mut2), micromolar concentrations of strychnine elicited inward currents that were reversibly inhibited by the nicotinic receptor blocker α-bungarotoxin. Single-channel recordings showed that strychnine gated mut2-channels with two conductance levels, 56 pS and 42 pS, and with kinetic properties similar to AcCho-activated channels. We conclude that strychnine is a modulator, as well as an activator, of some homomeric nicotinic α7 receptors. After injecting oocytes with mixtures of cDNAs encoding mut1 and mut2 subunits, the expressed hybrid receptors were activated by strychnine, similar to the mut2, and had a high affinity to AcCho like the mut1. A pentameric symmetrical model yields the striking conclusion that two identical α7 subunits may be sufficient to determine the functional properties of α7 receptors. PMID:10557336

  14. Multinational Home Use of Closed-Loop Control Is Safe and Effective

    PubMed Central

    Anderson, Stacey M.; Raghinaru, Dan; Pinsker, Jordan E.; Boscari, Federico; Renard, Eric; Buckingham, Bruce A.; Nimri, Revital; Doyle, Francis J.; Brown, Sue A.; Keith-Hynes, Patrick; Breton, Marc D.; Chernavvsky, Daniel; Bevier, Wendy C.; Bradley, Paige K.; Bruttomesso, Daniela; Del Favero, Simone; Calore, Roberta; Cobelli, Claudio; Avogaro, Angelo; Farret, Anne; Place, Jerome; Ly, Trang T.; Shanmugham, Satya; Phillip, Moshe; Dassau, Eyal; Dasanayake, Isuru S.; Kollman, Craig; Lum, John W.; Beck, Roy W.; Kovatchev, Boris

    2016-01-01

    OBJECTIVE To evaluate the efficacy of a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs] running the Unified Safety System) on glucose control at home in overnight-only and 24/7 closed-loop control (CLC) modes in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS At six clinical centers in four countries, 30 participants 18–66 years old with type 1 diabetes (43% female, 96% non-Hispanic white, median type 1 diabetes duration 19 years, median A1C 7.3%) completed the study. The protocol included a 2-week baseline sensor-augmented pump (SAP) period followed by 2 weeks of overnight-only CLC and 2 weeks of 24/7 CLC at home. Glucose control during CLC was compared with the baseline SAP. RESULTS Glycemic control parameters for overnight-only CLC were improved during the nighttime period compared with baseline for hypoglycemia (time <70 mg/dL, primary end point median 1.1% vs. 3.0%; P < 0.001), time in target (70–180 mg/dL: 75% vs. 61%; P < 0.001), and glucose variability (coefficient of variation: 30% vs. 36%; P < 0.001). Similar improvements for day/night combined were observed with 24/7 CLC compared with baseline: 1.7% vs. 4.1%, P < 0.001; 73% vs. 65%, P < 0.001; and 34% vs. 38%, P < 0.001, respectively. CONCLUSIONS CLC running on a smartphone (DiAs) in the home environment was safe and effective. Overnight-only CLC reduced hypoglycemia and increased time in range overnight and increased time in range during the day; 24/7 CLC reduced hypoglycemia and increased time in range both overnight and during the day. Compared with overnight-only CLC, 24/7 CLC provided additional hypoglycemia protection during the day. PMID:27208316

  15. Genetic Association of CD247 (CD3ζ) with SLE in a Large-Scale Multiethnic Study

    PubMed Central

    Martins, Madalena; Williams, Adrienne H.; Comeau, Mary; Marion, Miranda; Ziegler, Julie T.; Freedman, Barry I.; Merrill, Joan T.; Glenn, Stuart B.; Kelly, Jennifer A.; Sivils, Kathy M.; James, Judith A.; Guthridge, Joel M.; Alarcón-Riquelme, Marta E.; Bae, Sang-Cheol; Kim, Jae-Hoon; Kim, Dam; Anaya, Juan-Manuel; Boackle, Susan A.; Criswell, Lindsey A.; Kimberly, Robert P.; Alarcón, Graciela S.; Brown, Elizabeth E.; Vilá, Luis M.; Petri, Michelle A.; Ramsey-Goldman, Rosalind; Niewold, Timothy B.; Tsao, Betty P.; Gilkeson, Gary S.; Kamen, Diane L.; Jacob, Chaim O.; Stevens, Anne M.; Gaffney, Patrick M.; Harley, John B.; Langefeld, Carl D.; Fesel, Constantin

    2015-01-01

    A classic T-cell phenotype in Systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters TCR signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multi-ethnic population. We typed 44 contiguous CD247 SNPs in 8 922 SLE patients and 8 077 controls from four ethnically distinct populations. The strongest associations were found in the Asian population (11 SNPs in intron 1, 4.99×10−4

  16. Trypsin activation pathway of rotavirus infectivity.

    PubMed Central

    Arias, C F; Romero, P; Alvarez, V; López, S

    1996-01-01

    The infectivity of rotaviruses is increased by and most probably is dependent on trypsin treatment of the virus. This proteolytic treatment specifically cleaves VP4, the protein that forms the spikes on the surface of the virions, to polypeptides VP5 and VP8. This cleavage has been reported to occur in rotavirus SA114fM at two conserved, closely spaced arginine residues located at VP4 amino acids 241 and 247. In this work, we have characterized the VP4 cleavage products of rotavirus SA114S generated by in vitro treatment of the virus with increasing concentrations of trypsin and with proteases AspN and alpha-chymotrypsin. The VP8 and VP5 polypeptides were analyzed by gel electrophoresis and by Western blotting (immunoblotting) with antibodies raised to synthetic peptides that mimic the terminal regions of VP4 generated by the trypsin cleavage. It was shown that in addition to arginine residues 241 and 247, VP4 is cleaved at arginine residue 231. These three sites were found to have different susceptibilities to trypsin, Arg-241 > Arg-231 > Arg-247, with the enhancement of infectivity correlating with cleavage at Arg-247 rather than at Arg-231 or Arg-241. Proteases AspN and alpha-chymotrypsin cleaved VP4 at Asp-242 and Tyr-246, respectively, with no significant enhancement of infectivity, although this enhancement could be achieved by further treatment of the virus with trypsin. The VP4 end products of trypsin treatment were a homogeneous VP8 polypeptide comprising VP4 amino acids 1 to 231 and a heterogeneous VP5, which is formed by two polypeptide species (present at a ratio of approximately 1:5) as a result of cleavage at either Arg-241 or Arg-247. A pathway for the trypsin activation of rotavirus infectivity is proposed. PMID:8709201

  17. The centre of NGC 247

    NASA Image and Video Library

    2016-10-03

      This Hubble image shows the central region of a spiral galaxy known as NGC 247. NGC 247 is a relatively small spiral galaxy in the southern constellation of Cetus (The Whale). Lying at a distance of around 11 million light-years from us, it forms part of the Sculptor Group, a loose collection of galaxies that also contains the more famous NGC 253 (otherwise known as the Sculptor Galaxy). NGC 247’s nucleus is visible here as a bright, whitish patch, surrounded by a mixture of stars, gas and dust. The dust forms dark patches and filaments that are silhouetted against the background of stars, while the gas has formed into bright knots known as H II regions, mostly scattered throughout the galaxy’s arms and outer areas. This galaxy displays one particularly unusual and mysterious feature — it is not visible in this image, but can be seen clearly in wider views of the galaxy, such as this picture from ESO’s MPG/ESO 2.2-metre telescope. The northern part of NGC 247’s disc hosts an apparent void, a gap in the usual swarm of stars and H II regions that spans almost a third of the galaxy’s total length. There are stars within this void, but they are quite different from those around it. They are significantly older, and as a result much fainter and redder. This indicates that the star formation taking place across most of the galaxy’s disc has somehow been arrested in the void region, and has not taken place for around one billion years. Although astronomers are still unsure how the void formed, recent studies suggest it might have been caused by gravitational interactions with part of another galaxy.

  18. Origin of uranium isotope variations in early solar nebula condensates.

    PubMed

    Tissot, François L H; Dauphas, Nicolas; Grossman, Lawrence

    2016-03-01

    High-temperature condensates found in meteorites display uranium isotopic variations ((235)U/(238)U), which complicate dating the solar system's formation and whose origin remains mysterious. It is possible that these variations are due to the decay of the short-lived radionuclide (247)Cm (t 1/2 = 15.6 My) into (235)U, but they could also be due to uranium kinetic isotopic fractionation during condensation. We report uranium isotope measurements of meteoritic refractory inclusions that reveal excesses of (235)U reaching ~+6% relative to average solar system composition, which can only be due to the decay of (247)Cm. This allows us to constrain the (247)Cm/(235)U ratio at solar system formation to (1.1 ± 0.3) × 10(-4). This value provides new clues on the universality of the nucleosynthetic r-process of rapid neutron capture.

  19. Ionization cross section, pressure shift and isotope shift measurements of osmium

    NASA Astrophysics Data System (ADS)

    Hirayama, Yoshikazu; Mukai, Momo; Watanabe, Yutaka; Oyaizu, Michihiro; Ahmed, Murad; Kakiguchi, Yutaka; Kimura, Sota; Miyatake, Hiroari; Schury, Peter; Wada, Michiharu; Jeong, Sun-Chan

    2017-11-01

    In-gas-cell laser resonance ionization spectroscopy of neutral osmium atoms was performed with the use of a two-color two-step laser resonance ionization technique. Saturation curves for the ionization scheme were measured, and the ionization cross section was experimentally determined by solving the rate equations for the ground, intermediate and ionization continuum populations. The pressure shift and pressure broadening in the resonance spectra of the excitation transition were measured. The electronic factor {F}247 for the transition {λ }1=247.7583 nm to the intermediate state was deduced from the measured isotope shifts of stable {}{188,189,{190,192}}Os isotopes. The efficient ionization scheme, pressure shift, nuclear isotope shift and {F}247 are expected to be useful for applications of laser ion sources to unstable nuclei and for nuclear spectroscopy based on laser ionization techniques.

  20. [Considerations on the antibiotic activity (M.I.C.) revealed in 247 serotypes of Salmonella].

    PubMed

    Pitzus, E; Peretti, P; Ghinelli, P; Bisicchia, R; Turano, A

    1975-01-01

    247 strains of Salmonella, isolated in Brescia province duriing 1973-1974 have been typed by serological methods. The MIC has been determined, using the following antibiotics: chloramphenicol, tetracycline HCL, ampicillin, doxycycline, rifampicin, cephazolin, carbenicillin, nifuratel, gentamicin, aminosidine, trimetho-prim-sulphamethoazole, nalidixic acid. The pattern of resistence of the various serotypes is quite constant. The relationship between diffusion and epidermiological factors are discussed.

  1. 48 CFR 52.247-45 - F.o.b. Origin and/or F.o.b. Destination Evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Origin and/or F.o.b... Clauses 52.247-45 F.o.b. Origin and/or F.o.b. Destination Evaluation. As prescribed in 47.305-2(b), insert the following provision in solicitations when offers are solicited on the basis of both f.o.b. origin...

  2. Endoglucanase and xylanase production by Bacillus sp. AR03 in co-culture.

    PubMed

    Hero, Johan S; Pisa, José H; Perotti, Nora I; Romero, Cintia M; Martínez, María A

    2017-07-03

    The behavior of three isolates retrieved from different cellulolytic consortia, Bacillus sp. AR03, Paenibacillus sp. AR247 and Achromobacter sp. AR476-2, were examined individually and as co-cultures in order to evaluate their ability to produce extracellular cellulases and xylanases. Utilizing a peptone-based medium supplemented with carboxymethyl cellulose (CMC), an increase estimation of 1.30 and 1.50 times was obtained by the co-culture containing the strains AR03 and AR247, with respect to enzyme titles registered by their individual cultivation. On the contrary, the extracellular enzymatic production decreased during the co-cultivation of strain AR03 with the non-cellulolytic Achromobacter sp. AR476-2. The synergistic behavior observed through the combined cultivation of the strains AR03 and AR247 might be a consequence of the consumption by Paenibacillus sp. AR247 of the products of the CMC hydrolysis (i.e., cellobiose and/or cello-oligosaccharides), which were mostly generated by the cellulase producer Bacillus sp. AR03. The effect observed could be driven by the requirement to fulfill the nutritional supply from both strains on the substrate evaluated. These results would contribute to a better description of the degradation of the cellulose fraction of the plant cell walls in nature, expected to an efficient utilization of renewable sources.

  3. Carbohydrate Supplementation and Immune Responses After Acute Exhaustive Resistance Exercise

    DTIC Science & Technology

    2008-01-01

    247 International Journal of Sport Nutrition and Exercise Metabolism, 2008, 18, 247-259 © 2008 Human Kinetics , Inc. Carlson is with the Dept. of...the men who participated in the study. References Bachle, T.R., & Earle, R.W. (2000). Essentials of strength and conditioning. Champaign, IL: Human ... Kinetics . Dill, D.B., & Costill, D.L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of

  4. Ruggedized Portable Instrumentation Package for Marine Mammal Evoked Potential Hearing Measurements (DURIP)

    DTIC Science & Technology

    2011-09-30

    NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Hawaii Institute of Marine Biology,Marine Mammal...Program Hawaii Institute of Marine Biology P.O. Box 1106 Kailua, Hawaii 96734 phone: (808) 247-5297 fax: (808) 247-5831 email: nachtiga...portable equipment was used at the Hilo Stranding Center to obtain the audiograms. Ready and available for RIMPAC excercises. 2 IMPACT

  5. Metallic and Ceramic Materials Research. Task Order 0005: Metallic, Materials, Methods, Characterization and Testing Research

    DTIC Science & Technology

    2015-10-01

    articles and papers, and is referenced in the text. 15. SUBJECT TERMS high entropy alloys, titanium, inertia welding 16. SECURITY...A. Approved for public release; distribution unlimited. List of Figures Figure 1: (a) Fracture surface of a LSHR/Mar-M247 weld specimen fractured...in Mar-M247 region ~6 mm apart from the weld interface. (b-c) Higher magnification images illustrating (b) a blocky, faceted appearance of fracture

  6. The Properties of Large Amplitude Whistler Mode Waves in the Magnetosphere: Propagation and Relationship with Geomagnetic Activity

    NASA Technical Reports Server (NTRS)

    Wilson, L. B., III; Cattell, C. A.; Kellogg, P. J.; Wygant, J. R.; Goetz, K.; Breneman, A.; Kersten, K.

    2011-01-01

    Wepresent resultsof a studyof the characteristicsof very large amplitude whistler mode waves inside the terrestrial magnetosphere at radial distances of less than 15 RE using waveform capture data from the Wind spacecraft. We observed 247 whistler mode waves with at least one electric field component (105/247 had !80 mV/m peak!to!peak amplitudes) and 66 whistler mode waves with at least one search coil magnetic field component (38/66 had !0.8 nT peak!to!peak amplitudes). Wave vectors determined from events with three magnetic field components indicate that 30/46 propagate within 20 of the ambient magnetic field, though some are more oblique (up to "50 ). No relationship was observed between wave normal angle and GSM latitude. 162/247 of the large amplitude whistler mode waves were observed during magnetically active periods (AE > 200 nT). 217 out of 247 total whistler mode waves examined were observed inside the radiation belts. We present a waveform capture with the largest whistler wave magnetic field amplitude (^8 nT peak!to!peak) ever reported in the radiation belts. The estimated Poynting flux magnitude associated with this wave is ^300 mW/m2, roughly four orders of magnitude above estimates from previous satellite measurements. Such large Poynting flux values are consistent with rapid energization of electrons.

  7. Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis.

    PubMed

    Hai, Tang; Guo, Weiwei; Yao, Jing; Cao, Chunwei; Luo, Ailing; Qi, Meng; Wang, Xianlong; Wang, Xiao; Huang, Jiaojiao; Zhang, Ying; Zhang, Hongyong; Wang, Dayu; Shang, Haitao; Hong, Qianlong; Zhang, Rui; Jia, Qitao; Zheng, Qiantao; Qin, Guosong; Li, Yongshun; Zhang, Tao; Jin, Weiwu; Chen, Zheng-Yi; Wang, Hongmei; Zhou, Qi; Meng, Anming; Wei, Hong; Yang, Shiming; Zhao, Jianguo

    2017-11-01

    Human Waardenburg syndrome 2A (WS2A) is a dominant hearing loss (HL) syndrome caused by mutations in the microphthalmia-associated transcription factor (MITF) gene. In mouse models with MITF mutations, WS2A is transmitted in a recessive pattern, which limits the study of hearing loss (HL) pathology. In the current study, we performed ENU (ethylnitrosourea) mutagenesis that resulted in substituting a conserved lysine with a serine (p. L247S) in the DNA-binding domain of the MITF gene to generate a novel miniature pig model of WS2A. The heterozygous mutant pig (MITF +/L247S ) exhibits a dominant form of profound HL and hypopigmentation in skin, hair, and iris, accompanied by degeneration of stria vascularis (SV), fused hair cells, and the absence of endocochlear potential, which indicate the pathology of human WS2A. Besides hypopigmentation and bilateral HL, the homozygous mutant pig (MITF L247S/L247S ) and CRISPR/Cas9-mediated MITF bi-allelic knockout pigs both exhibited anophthalmia. Three WS2 patients carrying MITF mutations adjacent to the corresponding region were also identified. The pig models resemble the clinical symptom and molecular pathology of human WS2A patients perfectly, which will provide new clues for better understanding the etiology and development of novel treatment strategies for human HL.

  8. Multinational Home Use of Closed-Loop Control Is Safe and Effective.

    PubMed

    Anderson, Stacey M; Raghinaru, Dan; Pinsker, Jordan E; Boscari, Federico; Renard, Eric; Buckingham, Bruce A; Nimri, Revital; Doyle, Francis J; Brown, Sue A; Keith-Hynes, Patrick; Breton, Marc D; Chernavvsky, Daniel; Bevier, Wendy C; Bradley, Paige K; Bruttomesso, Daniela; Del Favero, Simone; Calore, Roberta; Cobelli, Claudio; Avogaro, Angelo; Farret, Anne; Place, Jerome; Ly, Trang T; Shanmugham, Satya; Phillip, Moshe; Dassau, Eyal; Dasanayake, Isuru S; Kollman, Craig; Lum, John W; Beck, Roy W; Kovatchev, Boris

    2016-07-01

    To evaluate the efficacy of a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs] running the Unified Safety System) on glucose control at home in overnight-only and 24/7 closed-loop control (CLC) modes in patients with type 1 diabetes. At six clinical centers in four countries, 30 participants 18-66 years old with type 1 diabetes (43% female, 96% non-Hispanic white, median type 1 diabetes duration 19 years, median A1C 7.3%) completed the study. The protocol included a 2-week baseline sensor-augmented pump (SAP) period followed by 2 weeks of overnight-only CLC and 2 weeks of 24/7 CLC at home. Glucose control during CLC was compared with the baseline SAP. Glycemic control parameters for overnight-only CLC were improved during the nighttime period compared with baseline for hypoglycemia (time <70 mg/dL, primary end point median 1.1% vs. 3.0%; P < 0.001), time in target (70-180 mg/dL: 75% vs. 61%; P < 0.001), and glucose variability (coefficient of variation: 30% vs. 36%; P < 0.001). Similar improvements for day/night combined were observed with 24/7 CLC compared with baseline: 1.7% vs. 4.1%, P < 0.001; 73% vs. 65%, P < 0.001; and 34% vs. 38%, P < 0.001, respectively. CLC running on a smartphone (DiAs) in the home environment was safe and effective. Overnight-only CLC reduced hypoglycemia and increased time in range overnight and increased time in range during the day; 24/7 CLC reduced hypoglycemia and increased time in range both overnight and during the day. Compared with overnight-only CLC, 24/7 CLC provided additional hypoglycemia protection during the day. © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

  9. Guidelines for Designing User Interface Software

    DTIC Science & Technology

    1986-08-01

    2.4.4 Bar Graphs 150 2.4.5 Pie Charts 154 2.4.6 Pictures and Diagrams 156 2.4.7 Flowcharts 159 2.4.8 Maps and Situation Displays 163 2.5 Format...Pictures and diagrams 156 2.4.7 Flowcharts 159 2.4.8 Maps and situation displays 163 2.5 Format refers to the organization of different types of...computer aids for calculating area, volume, center of gravity, modes of vibration, stresses, heat transfer, etc. 158 DATA DISPLAY Flowcharts

  10. Proposed Functional Architecture and Associated Benefits Analysis of a Common Ground Control Station for Unmanned Aircraft Systems

    DTIC Science & Technology

    2010-03-01

    143 Table 12. High Level Analysis of O&S Costs of Different Training Options...Station On station 24/7 ( ETOS 80%) On station 24/7 for 30 consecutive days ( ETOS 95%) Mission Radius ≥ 2,000 nm ≥ 3,000 nm Net Ready-KPP COMMON...Training with As-Is Unique GCS Architectures 143 The results of the analysis for BUQs I-IV are shown in Table 11. The data shows that

  11. Final Remedial Investigation Sampling Plan Addendum. Milan Army Ammunition Plant Remedial Investigation Southern Study Area (Operable Unit No. 5)

    DTIC Science & Technology

    1997-09-01

    91-D-0012 Task Order No. 0007 2.4.7 Milan Army Ammunition Plant, Phytoremediation Pilot Study, USAEC, 1996 .. .............................. 2-28 2.5...indicated that heavy metal contamination (lead, chromium, and mercury ) was present at relatively low levels, and explosive contamination was limited to...and MI172 where lead was found at 22.9 j.g/1 and 18.4 Ig/l, respectively. 2.4.7 Milan Army Ammunition Plant, Phytoremediation Pilot Study, USAEC, 1996

  12. Antigenic Diversity of the Plasmodium vivax Circumsporozoite Protein in Parasite Isolates of Western Colombia

    PubMed Central

    Hernández-Martínez, Miguel Ángel; Escalante, Ananías A.; Arévalo-Herrera, Myriam; Herrera, Sócrates

    2011-01-01

    Circumsporozoite (CS) protein is a malaria antigen involved in sporozoite invasion of hepatocytes, and thus considered to have good vaccine potential. We evaluated the polymorphism of the Plasmodium vivax CS gene in 24 parasite isolates collected from malaria-endemic areas of Colombia. We sequenced 27 alleles, most of which (25/27) corresponded to the VK247 genotype and the remainder to the VK210 type. All VK247 alleles presented a mutation (Gly → Asn) at position 28 in the N-terminal region, whereas the C-terminal presented three insertions: the ANKKAGDAG, which is common in all VK247 isolates; 12 alleles presented the insertion GAGGQAAGGNAANKKAGDAG; and 5 alleles presented the insertion GGNAGGNA. Both repeat regions were polymorphic in gene sequence and size. Sequences coding for B-, T-CD4+, and T-CD8+ cell epitopes were found to be conserved. This study confirms the high polymorphism of the repeat domain and the highly conserved nature of the flanking regions. PMID:21292878

  13. Effect of grain orientation and coating on thermal fatigue resistance of a directionally solidified superalloy (MAR-M 247)

    NASA Technical Reports Server (NTRS)

    Bizon, P. T.; Dreshfield, R. L.; Calfo, F. D.

    1979-01-01

    The effect of off-axis directionally solidified (DS) grain growth on thermal fatigue life of Mar-M 247 alloy was evaluated. Uncoated conventionally cast as well as DS wedge bars were cycled in a burner rig between 1070 C and room temperature. The longitudinal axis and leading edge of the specimen coincided. As the angle between the specimen longitudinal axis and growth axis increased, the thermal fatigue life decreased for both the uncoated and aluminide-coated bars. Life increases of about 50 cycles for the DS conditions were attributed to coating. The decrease in thermal fatigue life with increasing angle is primarily attributed to the increase in modulus of elasticity with increasing angle and not to the intersection of DS grain boundaries with the specimen leading edge. The thermal fatigue cracks were observed to be transgranular in the DS material. Limited tensile and stress-rupture properties of conventionally cast and off-axis DS Mar-M 247 alloy are also presented.

  14. Effects of MAR-M247 substrate (modified) composition on coating oxidation coating/substrate interdiffusion. M.S. Thesis. Final Report; [protective coatings for hot section components of gas turbine engines

    NASA Technical Reports Server (NTRS)

    Pilsner, B. H.

    1985-01-01

    The effects of gamma+gamma' Mar-M247 substrate composition on gamma+beta Ni-Cr-Al-Zr coating oxidation and coating/substrate interdiffusion were evaluated. These results were also compared to a prior study for a Ni-Cr-Al-Zr coated gamma Ni-Cr-Al substrate with equivalent Al and Cr atomic percentages. Cyclic oxidation behavior at 1130 C was investigated using change in weight curves. Concentration/distance profiles were measured for Al, Cr, Co, W, and Ta. The surface oxides were examined by X-ray diffraction and scanning electron microscopy. The results indicate that variations of Ta and C concentrations in the substrate do not affect oxidation resistance, while additions of grain boundary strengthening elements (Zr, Hf, B) increase oxidation resistance. In addition, the results indicate that oxidation phenomena in gamma+beta/gamma+gamma' Mar-M247 systems have similar characteristics to the l gamma+beta/gamma Ni-Cr-Al system.

  15. Maintenance of certification: current attitudes of members of the American Society of Neuroradiology.

    PubMed

    Yousem, D M

    2008-02-01

    The maintenance of certification (MOC) process has begun in radiology, and many physicians will be affected by it. We sought to assess the compliance with and knowledge of the MOC steps by American Society of Neuroradiology (ASNR) members. An on-line survey was distributed via e-mail to the members of the ASNR for whom e-mail addresses were available. The survey addressed 3 components of the MOC currently implemented: 1) MOC cognitive examinations, 2) self-assessment modules (SAMs), and 3) continuing medical education (CME) credits. The response rate was 1020/2662 (38.3%). Of those responding, 11% stated that they either do not support the MOC examination (8%) or were unaware of it (3%), 21.4% of respondents have completed an SAM module, but >30% were unaware that they had to complete SAMs or did not know where they were offered. Many members will receive most of their 25 required CME hours for 2007 from sources besides the ASNR annual meeting. Of the small proportion of respondents who made comments (247/1020, 24.2%), those about the MOC process were favorable in 6.1% (15/247), unfavorable in 46.6% (115/247), and neutral in 47.4% (117/247). The MOC process remains poorly understood, with limited compliance. The radiology societies should spend additional effort publicizing the requirements and offering support and products aimed at allowing their members to achieve compliance in a reasonable cost-effective fashion.

  16. The Araucaria Project: The Distances to the NGC 247 and WLM Galaxies From Cepheid Variables Discovered in a Wide-Field Imaging Survey

    NASA Astrophysics Data System (ADS)

    García, A.; Gieren, W.; Pietrzynski, G.

    2009-05-01

    Two different and extensive wide-field imaging surveys for Cepheid variables have been made in the Sculptor Group galaxy NGC 247 and in the Local Group Irregular galaxy WLM. We present the principal results obtained in this surveys in the context of the Araucaria project. We have discovered 60 Cepheids in WLM and 24 Cepheids in NGC 247. Our data define tight period-luminosity relations in V, I and the reddening-free Wesenheit magnitude W_I which are all extremely well fit by the corresponding slopes of the LMC Cepheid PL relation, suggesting no change of the PL relation slope down to a Cepheid metal abundance of about -1.0 dex, in agreement with other recent studies. We derive a true distance modulus to NGC 247 of 27.80+/-0.09 (r) +/-0.06 (s) mag from our data, in good agreement with the earlier 27.9+/-0.1 mag determination of Davidge (2006, ApJ, 641, 822) from TRGB I band magnitude. The true distance modulus to WLM derived from our data was 25.144+/-0.03 (r) +/-0.07 (s), in good agreement with the earlier 24.92+/-0.21determination of Lee, Freedman, & Madore (1993, ApJ, 417, 553) from Cepheid variables. Aditional information is available in The Araucaria Project homepage (http://ezzelino.ifa.hawaii.edu/ bresolin/Araucaria/index.html) and in the series of papers entitled: The Araucaria Project.

  17. The radio sources CTA 21 and OF+247: The hot spots of radio galaxies

    NASA Astrophysics Data System (ADS)

    Artyukh, V. S.; Tyul'bashev, S. A.; Chernikov, P. A.

    2013-06-01

    The physical conditions in the radio sources CTA 21 and OF+247 are studied assuming that the low-frequency spectral turnovers are due to synchrotron self-absorption. The physical parameters of the radio sources are estimated using a technique based on a nonuniform synchrotron source model. It is shown that the magnetic-field distributions in the dominant compact components of these radio sources are strongly inhomogeneous. The magnetic fields at the center of the sources are B ˜ 10-1 G, and the fields are two to three orders of magnitude weaker at the periphery. The magnetic field averaged over the compact component is B ˜ 10-3 G, and the density of relativistic electrons is n e ˜ 10-3 cm-3. Assuming that there is equipartition of the energies of the magnetic field and relativistic particles, averaged over the source, < E H > = < E e > ˜ 10-7-10-6 erg cm-3. The energy density of the magnetic field exceeds that of the relativistic electrons at the centers of the radio sources. The derived parameters of CTA 21 and OF+247 are close to those of the hot spots in the radio galaxy Cygnus A. On this basis, it is suggested that CTA 21 and OF+247 are radio galaxies at an early stage of their evolution, when the hot spots (dominant compact radio components) have appeared, and the radio lobes (weak extended components) are still being formed.

  18. Cumulative fatigue damage behavior of MAR M-247

    NASA Technical Reports Server (NTRS)

    Mcgaw, Michael A.; Halford, Gary R.; Kalluri, Sreeramesh

    1991-01-01

    The objective was to examine the room temperature fatigue and nonlinear cumulative fatigue damage behavior of the cast nickel-based superalloy, MAR M-247. The fatigue test matrix consisted of single-level, fully reversed fatigue experiments. Two series of tests were performed: one of the two baseline fatigue LCF (Low-Cycle Fatigue) life levels was used in the first loading block, and the HCF (High-Cycle Fatigue) baseline loading level was used in the second block in each series. For each series, duplicate tests were performed at each applied LCF life fraction.

  19. Nursing staffs self-perceived outcome from a rehabilitation 24/7 educational programme - a mixed-methods study in stroke care.

    PubMed

    Loft, M I; Esbensen, B A; Kirk, K; Pedersen, L; Martinsen, B; Iversen, H; Mathiesen, L L; Poulsen, I

    2018-01-01

    During the past two decades, attempts have been made to describe nurses' contributions to the rehabilitation of inpatients following stroke. There is currently a lack of interventions that integrate the diversity of nurses' role and functions in stroke rehabilitation and explore their effect on patient outcomes. Using a systematic evidence- and theory-based design, we developed an educational programme, Rehabilitation 24/7, for nursing staff working in stroke rehabilitation aiming at two target behaviours; working systematically with a rehabilitative approach in all aspects of patient care and working deliberately and systematically with patients' goals. The aim of this study was to assess nursing staff members' self-perceived outcome related to their capability, opportunity and motivation to work with a rehabilitative approach after participating in the stroke Rehabilitation 24/7 educational programme. A convergent mixed-method design was applied consisting of a survey and semi-structured interviews. Data collection was undertaken between February and June 2016. Data from the questionnaires ( N  = 33) distributed before and after the intervention were analysed using descriptive statistics and Wilcoxon sign rank test. The interviews ( N  = 10) were analysed using deductive content analysis. After analysing questionnaires and interviews separately, the results were merged in a side by side comparison presented in the discussion. The results from both the quantitative and qualitative analyses indicate that the educational programme shaped the target behaviours that we aimed to change by addressing the nursing staff's capability, opportunity and motivation and hence could strengthen the nursing staff's contribution to inpatient stroke rehabilitation. A number of behaviours changed significantly, and the qualitative results indicated that the staff experienced increased focus on their role and functions in rehabilitation practice. Our study provides an understanding of the outcome of the Rehabilitation 24/7 educational programme on nursing staff's behaviours. A mixed-methods approach provided extended knowledge of the changes in the nursing staff members' self-percived behaviours after the intervention. These changes suggest that educating the nursing staff on rehabilitation using the Rehabilitation 24/7 programme strengthened their knowledge and beliefs about rehabilitation, goal-setting as well as their role and functions .

  20. A descriptive study of access to services in a random sample of Canadian rural emergency departments.

    PubMed

    Fleet, Richard; Poitras, Julien; Maltais-Giguère, Julie; Villa, Julie; Archambault, Patrick

    2013-11-27

    To examine 24/7 access to services and consultants in a sample of Canadian rural emergency departments (EDs). Cross-sectional study-mixed methods (structured interview, survey and government data bases) with random sampling of hospitals. Canadian rural EDs (rural small town (RST) definition-Statistics Canada). 28% (95/336) of Canadian rural EDs providing 24/7 physician coverage located in hospitals with acute care hospitalisation beds. General characteristics of the rural EDs, information about 24/7 access to consultants, equipment and services, and the proportion of rural hospitals more than 300 km from levels 1 and 2 trauma centres. Of the 336 rural EDs identified, 122 (36%) were randomly selected and contacted. Overall, 95 EDs participated in the study (participation rate, 78%). Hospitals had, on an average, 23 acute care beds, 7 ED stretchers and 13 500 annual ED visits. The proportion of rural hospitals with local access to the following 24/7 services was paediatrician, 5%; obstetrician, 10%; psychiatrist, 11%; internist, 12%; intensive care unit, 17%; CT scanner, 20%; surgeon, 26%; ultrasound, 28%; basic X-ray, 97% and laboratory services, 99%. Forty-four per cent and 54% of the RST EDs were more than 300 km from a level 1 and level 2 trauma centre, respectively. This is the first study describing the services available in Canadian rural EDs. Apart from basic laboratory and X-ray services, most rural EDs have limited access to consultants, advanced imaging and critical care services. A detailed study is needed to evaluate the impact of these limited services on patient outcomes, costs and interfacility transport demands.

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