Sample records for einsteinium 248

  1. Einsteinium

    NASA Astrophysics Data System (ADS)

    Haire, Richard G.

    The discovery of einsteinium, element 99, came about during the analyses of nuclear products produced in and then recovered from test debris following a thermonuclear explosion (weapon test device, ‘Mike', November 1952) at Eniwetok Atoll in the Pacific Ocean. The uranium present in this device was subjected to a very intense neutron flux (integrated fluence of about 1024neutrons) in an extremely short time frame (few nanoseconds), which allowed a large number of multiple neutron captures with a minimal degree of decay of the products formed. Nuclei were formed with usually high neutron/proton ratios (very ‘heavy' uranium isotopes), which then rapidly beta-decayed into new, transuranium isotopes through element 100. Scientists from several U.S. Government laboratories separated and analyzed extensively the debris samplings in the following weeks. From these investigations came the discovery and identification of einsteinium and fermium. The first element was named in honor of Albert Einstein, and assigned the symbol, E (later changed to the current symbol, Es). Additional details and discussions about the discovery of this element and the scientists involved are given in several references (Thompson et al., 1954; Ghiorso et al., 1955; Fields et al., 1956; Hyde et al., 1964; Seaborg and Loveland, 1990).

  2. Chemical Properties of Elements 99 and 100 [Einsteinium and Fermium

    DOE R&D Accomplishments Database

    Seaborg, G. T.; Thompson, S. G.; Harvey, B. G.; Choppin, G. R.

    1954-07-23

    A description of some of the chemical properties and of the methods used in the separations of elements 99 [Einsteinium] and 100 [Fermium] are given. The new elements exhibit the properties expected for the tenth and eleventh actinide elements. Attempts to produce an oxidation state greater than III of element 99 have been unsuccessful. In normal aqueous media only the III state of element 100 appears to exist. The relative spacings of the elution peaks of the new elements in some separations with ion exchange resin columns are the same as the relative spacings of the homologous lanthanide elements. The results of experiments involving cation exchange resins with very concentrated hydrochloric acid eluant show that the new elements, like the earlier actinides, are more strongly complexed than the lanthanides. The new elements also exist partially as anions in concentrated hydrochloric acid, as do earlier actinide elements, and they may be partially separated from each other by means of ion exchange resins. With some eluants interesting reversals of elution positions are observed in the region Bk-Cf-99-100, indicating complex ion formation involving unusual factors.

  3. BAG PASSOUT SEALER FOR WATER-SHIELDED CAVE FACILITY (Engineering Materials)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1963-10-31

    The water-shielded cave facility is used in processing irradiated slugs for recovery of americium, curium, berkelium, californium, einsteinium, and fermium. The remotely operated, plastic-bag passout sealer is used in removing isotopic fractions for storage in the rear or for removing radioactive waste for placement in the waste storage containers. The unit is accessible by both the primary inclosure master-slaves and the service area master-slaves. (F.L.S.)

  4. Handbook of Basic Atomic Spectroscopic Data

    National Institute of Standards and Technology Data Gateway

    SRD 108 Handbook of Basic Atomic Spectroscopic Data (Web, free access)   This handbook provides a selection of the most important and frequently used atomic spectroscopic data. The compilation includes data for the neutral and singly-ionized atoms of all elements hydrogen through einsteinium (Z = 1-99). The wavelengths, intensities, and spectrum assignments are given for each element, and the data for the approximately 12,000 lines of all elements are also collected into a single table.

  5. Systematization of actinides using cluster analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kopyrin, A.A.; Terent`eva, T.N.; Khramov, N.N.

    1994-11-01

    A representation of the actinides in multidimensional property space is proposed for systematization of these elements using cluster analysis. Literature data for their atomic properties are used. Owing to the wide variation of published ionization potentials, medians are used to estimate them. Vertical dendograms are used for classification on the basis of distances between the actinides in atomic-property space. The properties of actinium and lawrencium are furthest removed from the main group. Thorium and mendelevium exhibit individualized properties. A cluster based on the einsteinium-fermium pair is joined by californium.

  6. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  7. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  8. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  9. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  10. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119...

  11. CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.

    PubMed

    Wilhelm, Annika; Aldridge, Victoria; Haldar, Debashis; Naylor, Amy J; Weston, Christopher J; Hedegaard, Ditte; Garg, Abhilok; Fear, Janine; Reynolds, Gary M; Croft, Adam P; Henderson, Neil C; Buckley, Christopher D; Newsome, Philip N

    2016-07-01

    CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. CD248 expression was studied by immunostaining and quantitative PCR in both normal and diseased human and murine liver tissue and isolated hepatic stellate cells (HSCs). Hepatic fibrosis was induced in CD248(-/-) and wild-type controls with carbon tetrachloride (CCl4) treatment. Expression of CD248 was seen in normal liver of humans and mice but was significantly increased in liver injury using both immunostaining and gene expression assays. CD248 was co-expressed with a range of fibroblast/HSC markers including desmin, vimentin and α-smooth muscle actin (α-SMA) in murine and human liver sections. CD248 expression was restricted to isolated primary murine and human HSC. Collagen deposition and α-SMA expression, but not inflammation and neoangiogenesis, was reduced in CD248(-/-) mice compared with wild-type mice after CCl4 treatment. Isolated HSC from wild-type and CD248(-/-) mice expressed platelet-derived growth factor receptor α (PDGFR-α) and PDGFR-β at similar levels. As expected, PDGF-BB stimulation induced proliferation of wild-type HSC, whereas CD248(-/-) HSC did not demonstrate a proliferative response to PDGF-BB. Abrogated PDGF signalling in CD248(-/-) HSC was confirmed by significantly reduced c-fos expression in CD248(-/-) HSC compared with wild-type HSC. Our data show that deletion of CD248 reduces susceptibility to liver fibrosis via an effect on PDGF signalling, making it an attractive clinical target for the treatment of liver injury. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  12. Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis.

    PubMed

    Bartis, Domokos; Crowley, Louise E; D'Souza, Vijay K; Borthwick, Lee; Fisher, Andrew J; Croft, Adam P; Pongrácz, Judit E; Thompson, Richard; Langman, Gerald; Buckley, Christopher D; Thickett, David R

    2016-04-14

    CD248 or Endosialin is a transmembrane molecule expressed in stromal cells binding to extracellular matrix (ECM) components. It has been previously implicated in kidney fibrosis, rheumatoid arthritis as well as in tumour-stromal interactions. This study investigates the role of CD248 in the pathogenesis of fibrotic diseases in Idiopathic Pulmonary Fibrosis (IPF). CD248 quantitative immunohistochemistry (IHC) was performed on lung samples from 22 IPF patients and its expression was assayed in cultured pulmonary fibroblasts and epithelial cells. Effects of CD248 silencing was evaluated on fibroblast proliferation and myofibroblast differentiation. IHC revealed strong CD248 expression in mesenchymal cells of normal lung structures such as pleura and adventitia but not in epithelium. Fibrotic areas showed markedly stronger staining than unaffected lung tissue. The extent of CD248 staining showed a significant negative correlation to lung function parameters FEV1, FVC, TLC, and TLCO (r2 > 0 · 35, p < 0 · 01). CD248 protein levels were significantly greater in IPF-derived lung fibroblasts vs normal lung fibroblasts (p < 0 · 01) and CD248 silencing significantly reduced the proliferation of lung fibroblasts, but did not affected myofibroblast differentiation. We conclude that CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker. Given that CD248 ligands are collagen type I, IV and fibronectin, we hypothesise that CD248 signalling represents a novel matrix-fibroblast interaction that may be a potential therapeutic target in IPF.

  13. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  14. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  15. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  16. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  17. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  18. R248Q mutation--Beyond p53-DNA binding.

    PubMed

    Ng, Jeremy W K; Lama, Dilraj; Lukman, Suryani; Lane, David P; Verma, Chandra S; Sim, Adelene Y L

    2015-12-01

    R248 in the DNA binding domain (DBD) of p53 interacts directly with the minor groove of DNA. Earlier nuclear magnetic resonance (NMR) studies indicated that the R248Q mutation resulted in conformation changes in parts of DBD far from the mutation site. However, how information propagates from the mutation site to the rest of the DBD is still not well understood. We performed a series of all-atom molecular dynamics (MD) simulations to dissect sterics and charge effects of R248 on p53-DBD conformation: (i) wild-type p53 DBD; (ii) p53 DBD with an electrically neutral arginine side-chain; (iii) p53 DBD with R248A; (iv) p53 DBD with R248W; and (v) p53 DBD with R248Q. Our results agree well with experimental observations of global conformational changes induced by the R248Q mutation. Our simulations suggest that both charge- and sterics are important in the dynamics of the loop (L3) where the mutation resides. We show that helix 2 (H2) dynamics is altered as a result of a change in the hydrogen bonding partner of D281. In turn, neighboring L1 dynamics is altered: in mutants, L1 predominantly adopts the recessed conformation and is unable to interact with the major groove of DNA. We focused our attention the R248Q mutant that is commonly found in a wide range of cancer and observed changes at the zinc-binding pocket that might account for the dominant negative effects of R248Q. Furthermore, in our simulations, the S6/S7 turn was more frequently solvent exposed in R248Q, suggesting that there is a greater tendency of R248Q to partially unfold and possibly lead to an increased aggregation propensity. Finally, based on the observations made in our simulations, we propose strategies for the rescue of R248Q mutants. © 2015 Wiley Periodicals, Inc.

  19. 14 CFR 248.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Applicability. 248.1 Section 248.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS SUBMISSION OF AUDIT REPORTS § 248.1 Applicability. The requirements of this part shall be...

  20. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  1. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  2. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  3. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  4. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  5. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  6. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  7. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  8. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  9. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  10. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  11. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Other provisions. 248.24 Section 248.24 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24...

  12. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  13. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Other provisions. 248.24 Section 248.24 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24...

  14. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  15. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  16. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  17. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  18. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  19. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  20. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  1. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  2. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  3. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  4. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  5. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  6. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  7. 7 CFR 248.18 - Audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Audits. 248.18 Section 248.18 Agriculture Regulations... Agencies § 248.18 Audits. (a) Federal access to information. The Secretary, the Comptroller General of the... the purpose of making surveys, audits, examinations, excerpts, and transcripts. (b) State agency...

  8. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  9. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  10. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  11. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  12. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  13. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2011, an assessment rate of $0.003 per hundredweight is established for Washington potatoes...

  14. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2005, an assessment rate of $0.0035 per hundredweight is established for Washington potatoes...

  15. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2013, an assessment rate of $0.0025 per hundredweight is established for Washington potatoes...

  16. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2005, an assessment rate of $0.0035 per hundredweight is established for Washington potatoes...

  17. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2011, an assessment rate of $0.003 per hundredweight is established for Washington potatoes...

  18. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples...

  19. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this...

  20. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this...

  1. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this...

  2. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Safety analysis report updating. 72.248 Section 72.248 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF... Approval of Spent Fuel Storage Casks § 72.248 Safety analysis report updating. (a) Each certificate holder...

  3. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Examples. 248.102 Section 248... AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this subpart are not exclusive. The examples in this subpart provide guidance concerning the rules' application...

  4. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  5. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  6. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  7. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  8. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  9. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Nonfat dry milk. 58.248 Section 58.248 Agriculture... Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial....S. Standard Grade. (b) Regular nonfat dry milk in consumer size packages which bears an official...

  10. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Nonfat dry milk. 58.248 Section 58.248 Agriculture... Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial....S. Standard Grade. (b) Regular nonfat dry milk in consumer size packages which bears an official...

  11. 24 CFR 248.133 - Second notice of intent.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Second notice of intent. 248.133 Section 248.133 Housing and Urban Development Regulations Relating to Housing and Urban Development... Preservation and Resident Homeownership Act of 1990 § 248.133 Second notice of intent. (a) Filing. A second...

  12. 25 CFR 248.6 - Structures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Structures. 248.6 Section 248.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.6 Structures. Dwellings, camping facilities, and other structures such as fish drying facilities...

  13. 9 CFR 354.248 - Scope and applicability of rules of practice.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scope and applicability of rules of practice. 354.248 Section 354.248 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Maintenance of Sanitary Conditions and Precautions Against Contamination of Products § 354.248 Scope and...

  14. 17 CFR 248.201 - Duties regarding the detection, prevention, and mitigation of identity theft.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., prevention, and mitigation of identity theft. 248.201 Section 248.201 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-ID: Identity Theft Red Flags § 248.201 Duties regarding the detection, prevention, and mitigation of identity theft...

  15. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  16. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  17. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  18. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  19. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  20. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  1. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  2. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  3. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  4. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  5. 42 CFR 137.248 - What effect will a retrocession have on a retroceding Self-Governance Tribe's rights to contract...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... retroceding Self-Governance Tribe's rights to contract or compact under the Act? 137.248 Section 137.248 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Retrocession § 137.248 What effect will a...

  6. Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

    PubMed

    Hasemann, Marie S; Schuster, Mikkel B; Frank, Anne-Katrine; Theilgaard-Mönch, Kim; Pedersen, Thomas Å; Nerlov, Claus; Porse, Bo T

    2012-01-01

    Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro. Here, we use mouse genetics to investigate the significance of C/EBPα serine 248 in vivo through the construction and analysis of Cebpa(S248A/S248A) knock-in mice. Surprisingly, 8-week old Cebpa(S248A/S248A) mice display normal steady-state hematopoiesis including unaltered development of mature myeloid cells. However, over time some of the animals develop a hematopoietic disorder with accumulation of multipotent, megakaryocytic and erythroid progenitor cells and a mild impairment of differentiation along the granulocytic-monocytic lineage. Furthermore, BM cells from Cebpa(S248A/S248A) animals display a competitive advantage compared to wild type cells in a transplantation assay. Taken together, our data shows that the substitution of C/EBPα serine 248 to alanine favors the selection of the megakaryocytic/erythroid lineage over the monocytic/granulocytic compartment in old mice and suggests that S248 phosphorylation may be required to maintain proper hematopoietic homeostasis in response to changes in the wiring of cellular signalling networks. More broadly, the marked differences between the phenotype of the S248A variant in vivo and in vitro highlight the need to exert caution when extending in vitro phenotypes to the more appropriate in vivo context.

  7. Phosphorylation of Serine 248 of C/EBPα Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

    PubMed Central

    Frank, Anne-Katrine; Theilgaard-Mönch, Kim; Pedersen, Thomas Å.; Nerlov, Claus; Porse, Bo T.

    2012-01-01

    Background Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro. Methodology/Principal Findings Here, we use mouse genetics to investigate the significance of C/EBPα serine 248 in vivo through the construction and analysis of Cebpa S248A/S248A knock-in mice. Surprisingly, 8-week old Cebpa S248A/S248A mice display normal steady-state hematopoiesis including unaltered development of mature myeloid cells. However, over time some of the animals develop a hematopoietic disorder with accumulation of multipotent, megakaryocytic and erythroid progenitor cells and a mild impairment of differentiation along the granulocytic-monocytic lineage. Furthermore, BM cells from Cebpa S248A/S248A animals display a competitive advantage compared to wild type cells in a transplantation assay. Conclusions/Significance Taken together, our data shows that the substitution of C/EBPα serine 248 to alanine favors the selection of the megakaryocytic/erythroid lineage over the monocytic/granulocytic compartment in old mice and suggests that S248 phosphorylation may be required to maintain proper hematopoietic homeostasis in response to changes in the wiring of cellular signalling networks. More broadly, the marked differences between the phenotype of the S248A variant in vivo and in vitro highlight the need to exert caution when extending in vitro phenotypes to the more appropriate in vivo context. PMID:22715416

  8. 14 CFR 248.5 - Withholding from public disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEEDINGS) ECONOMIC REGULATIONS SUBMISSION OF AUDIT REPORTS § 248.5 Withholding from public disclosure. The special reports required to be filed by § 248.2 shall be withheld from public disclosure, until further...

  9. Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African-Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study

    PubMed Central

    Rivers, Charles A.; Barton, James C.; Gordeuk, Victor R.; Acton, Ronald T.; Speechley, Mark R.; Snively, Beverly M.; Leiendecker-Foster, Catherine; Press, Richard D.; Adams, Paul C.; McLaren, Gordon D.; Dawkins, Fitzroy W.; McLaren, Christine E.; Reboussin, David M.

    2007-01-01

    The ferroportin (FPN1) Q248H polymorphism has been associated with increased serum ferritin (SF) levels in sub-Saharan Africans and in African Americans (AA). AA participants of the HEIRS Study who did not have HFE C282Y or H63D who had elevated initial screening SF (≥300 μg/L in men and ≥200 μg/L in women) (defined as cases) were frequency-matched to AA participants with normal SF (defined as controls) to investigate the association of the Q248H with elevated SF. 10.4% of cases and 6.7% of controls were Q248H heterozygotes (P = 0.257). Q248H homozygosity was observed in 0.5% of the cases and none of the controls. The frequency of Q248H was higher among men with elevated SF than among control men (P = 0.047); corresponding differences were not observed among women. This appeared to be unrelated to self-reports of a previous diagnosis of liver disease. Men with elevated SF were three times more likely than women with elevated SF to have Q248H (P = 0.012). There were no significant differences in Q248H frequencies in men and women control participants. We conclude that the frequency of the FPN1 Q248H polymorphism is greater in AA men with elevated SF than in those with normal SF. PMID:17276706

  10. [Molecular pathogenesis of Waardenburg syndrome type II resulting from SOX10 gene mutation].

    PubMed

    Zhang, Hua; Chen, Hongsheng; Feng, Yong; Qian, Minfei; Li, Jiping; Liu, Jun; Zhang, Chun

    2016-08-01

    To explore the molecular mechanism of Waardenburg syndrome type II (WS2) resulting from SOX10 gene mutation E248fs through in vitro experiment. 293T cells were transiently transfected with wild type (WT) SOX10 and mutant type (MT) E248fs plasmids. The regulatory effect of WT/MT SOX10 on the transcriptional activity of MITF gene and influence of E248fs on WT SOX10 function were determined with a luciferase activity assay. The DNA binding capacity of the WT/MT SOX10 with the promoter of the MITF gene was determined with a biotinylated double-stranded oligonucleotide probe containing the SOX10 binding sequence cattgtc to precipitate MITF and E248fs, respectively. The stability of SOX10 and E248fs were also analyzed. As a loss-of-function mutation, the E248fs mutant failed to transactivate the MITF promoter as compared with the WT SOX10 (P<0.01), which also showed a dominant-negative effect on WT SOX10. The WT SOX10 and E248fs mutant were also able to bind specifically to the cattgtc motif in the MITF promoter, whereas E248fs had degraded faster than WT SOX10. Despite the fact that the E248fs has a dominant-negative effect on SOX10, its reduced stability may down-regulate the transcription of MITF and decrease the synthesis of melanin, which may result in haploinsufficiency of SOX10 protein and cause the milder WS2 phenotype.

  11. 76 FR 46807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... collections are mandatory. FR 2030 and FR 2030a: (12 U.S.C. 222, 282, 248(a) and 321). FR 2056: (12 U.S.C. 287, 248(a) and (i)). FR 2086: (12 U.S.C. 287, 248(a) and (i)). FR 2086a: (12 U.S.C. 321, 287, 248(a)). FR... to obtain a benefit (12 U.S.C. 338a, and 12 CFR 208.22). Individual respondent data generally are not...

  12. 24 CFR 248.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 248.1 Section 248.1 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

  13. 24 CFR 248.234 - Section 8 rental assistance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Section 8 rental assistance. 248.234 Section 248.234 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF...

  14. 24 CFR 248.234 - Section 8 rental assistance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Section 8 rental assistance. 248.234 Section 248.234 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF...

  15. 24 CFR 248.234 - Section 8 rental assistance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Section 8 rental assistance. 248.234 Section 248.234 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF...

  16. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  17. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  18. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  19. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  20. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  1. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  2. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  3. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  4. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  5. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  6. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  7. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  8. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  9. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  10. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  11. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  12. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  13. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  14. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  15. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  16. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  17. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  18. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  19. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  20. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  1. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  2. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  3. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  4. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  5. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  6. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  7. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  8. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  9. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  10. 17 CFR 248.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Purpose and scope. 248.1 Section 248.1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal...

  11. 31 CFR 248.7 - Claims requiring settlement action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Claims requiring settlement action. 248.7 Section 248.7 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... claimant and transmit such data to the Claims Division, General Accounting Office, for settlement action. ...

  12. 27 CFR 19.248 - Standard effective tax rate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Standard effective tax rate. 19.248 Section 19.248 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Distilled Spirits Taxes Effective Tax...

  13. 17 CFR 248.12 - Limits on sharing account number information for marketing purposes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... account number information for marketing purposes. (a) General prohibition on disclosure of account... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Limits on sharing account number information for marketing purposes. 248.12 Section 248.12 Commodity and Securities Exchanges...

  14. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  15. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  16. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  17. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  18. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  19. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  20. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  1. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  2. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  3. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  4. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  5. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  6. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  7. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  8. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  9. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  10. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  11. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  12. 17 CFR 248.18 - Effective date; transition rule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to consumers who are your customers on July 1, 2001, if, by that date, you have established a system... you have entered into with a nonaffiliated third party to perform services for you or functions on... rule. 248.18 Section 248.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

  13. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Undertaking of indemnity. 248.4 Section 248.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury...

  14. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  15. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  16. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  17. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  18. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  19. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  20. 24 CFR 248.135 - Plans of action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Plans of action. 248.135 Section... OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of 1990 § 248.135 Plans of action. (a) Submission. An owner seeking...

  1. 31 CFR 248.6 - Recovery of original check.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Recovery of original check. 248.6... § 248.6 Recovery of original check. (a) If the claimant recovers an original check after he has... or agency concerned regarding the negotiability of such original check. (b) In the event the...

  2. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... becomes your customer, not later than when you establish a customer relationship, except as provided in... as authorized by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer...

  3. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... later than when you establish a customer relationship, except as provided in paragraph (e) of this... by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer relationship when you...

  4. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... later than when you establish a customer relationship, except as provided in paragraph (e) of this... by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer relationship when you...

  5. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... later than when you establish a customer relationship, except as provided in paragraph (e) of this... by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer relationship when you...

  6. 17 CFR 248.17 - Relation to State laws.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Relation to State laws. 248.17... Information Relation to Other Laws; Effective Date § 248.17 Relation to State laws. (a) In general. This... inconsistency. (b) Greater protection under State law. For purposes of this section, a State statute, regulation...

  7. 17 CFR 248.5 - Annual privacy notice to customers required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... relationship exists. You may define the 12-consecutive-month period, but you must apply it to the customer on a.... (b)(1) Termination of customer relationship. You are not required to provide an annual notice to a... customers required. 248.5 Section 248.5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  8. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.127... period expires, you may not make marketing solicitations to a consumer who previously opted out, unless... provided in § 248.122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph...

  9. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  10. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P, S-AM, AND S-ID Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except...

  11. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  12. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  13. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  14. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Becker, Stephen Allan

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowsharemore » Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.« less

  15. The African swine fever virus virion membrane protein pE248R is required for virus infectivity and an early postentry event.

    PubMed

    Rodríguez, Irene; Nogal, María L; Redrejo-Rodríguez, Modesto; Bustos, María J; Salas, María L

    2009-12-01

    The African swine fever virus (ASFV) protein pE248R, encoded by the gene E248R, is a late structural component of the virus particle. The protein contains intramolecular disulfide bonds and has been previously identified as a substrate of the ASFV-encoded redox system. Its amino acid sequence contains a putative myristoylation site and a hydrophobic transmembrane region near its carboxy terminus. We show here that the protein pE248R is myristoylated during infection and associates with the membrane fraction in infected cells, behaving as an integral membrane protein. Furthermore, the protein localizes at the inner envelope of the virus particles in the cytoplasmic factories. The function of the protein pE248R in ASFV replication was investigated by using a recombinant virus that inducibly expresses the gene E248R. Under repressive conditions, the ASFV polyproteins pp220 and pp62 are normally processed and virus particles with morphology indistinguishable from that of those produced in a wild-type infection or under permissive conditions are generated. Moreover, the mutant virus particles can exit the cell as does the parental virus. However, the infectivity of the pE248R-deficient virions was reduced at least 100-fold. An investigation of the defect of the mutant virus indicated that neither virus binding nor internalization was affected by the absence of the protein pE248R, but a cytopathic effect was not induced and early and late gene expression was impaired, indicating that the protein is required for some early postentry event.

  16. The African Swine Fever Virus Virion Membrane Protein pE248R Is Required for Virus Infectivity and an Early Postentry Event ▿

    PubMed Central

    Rodríguez, Irene; Nogal, María L.; Redrejo-Rodríguez, Modesto; Bustos, María J.; Salas, María L.

    2009-01-01

    The African swine fever virus (ASFV) protein pE248R, encoded by the gene E248R, is a late structural component of the virus particle. The protein contains intramolecular disulfide bonds and has been previously identified as a substrate of the ASFV-encoded redox system. Its amino acid sequence contains a putative myristoylation site and a hydrophobic transmembrane region near its carboxy terminus. We show here that the protein pE248R is myristoylated during infection and associates with the membrane fraction in infected cells, behaving as an integral membrane protein. Furthermore, the protein localizes at the inner envelope of the virus particles in the cytoplasmic factories. The function of the protein pE248R in ASFV replication was investigated by using a recombinant virus that inducibly expresses the gene E248R. Under repressive conditions, the ASFV polyproteins pp220 and pp62 are normally processed and virus particles with morphology indistinguishable from that of those produced in a wild-type infection or under permissive conditions are generated. Moreover, the mutant virus particles can exit the cell as does the parental virus. However, the infectivity of the pE248R-deficient virions was reduced at least 100-fold. An investigation of the defect of the mutant virus indicated that neither virus binding nor internalization was affected by the absence of the protein pE248R, but a cytopathic effect was not induced and early and late gene expression was impaired, indicating that the protein is required for some early postentry event. PMID:19793823

  17. PCR-RFLP to Detect Codon 248 Mutation in Exon 7 of "p53" Tumor Suppressor Gene

    ERIC Educational Resources Information Center

    Ouyang, Liming; Ge, Chongtao; Wu, Haizhen; Li, Suxia; Zhang, Huizhan

    2009-01-01

    Individual genome DNA was extracted fast from oral swab and followed up with PCR specific for codon 248 of "p53" tumor suppressor gene. "Msp"I restriction mapping showed the G-C mutation in codon 248, which closely relates to cancer susceptibility. Students learn the concepts, detection techniques, and research significance of point mutations or…

  18. 17 CFR 248.13 - Exception to opt out requirements for service providers and joint marketing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exception to opt out requirements for service providers and joint marketing. 248.13 Section 248.13 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguardin...

  19. 31 CFR 248.3 - Advice of nonreceipt or loss.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Advice of nonreceipt or loss. 248.3... § 248.3 Advice of nonreceipt or loss. The payee or owner of a depositary check which is not received, or..., giving information as to the circumstances of the loss, theft or destruction of the check and whether it...

  20. 31 CFR 248.3 - Advice of nonreceipt or loss.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Advice of nonreceipt or loss. 248.3... § 248.3 Advice of nonreceipt or loss. The payee or owner of a depositary check which is not received, or..., giving information as to the circumstances of the loss, theft or destruction of the check and whether it...

  1. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the DPP or DOCD? 250.248 Section 250.248 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHEL...

  2. Training Implications of the Tactical Aircraft Recapitalization

    DTIC Science & Technology

    2008-06-13

    and Wayne L. Waag , The Use of Simulators for Training In-Flight and Emergency Procedures in AGARD-AG-248 (Neuilly-Sur-Seine, France: Advisory Group...11 Edward E. Eddowes and Wayne L. Waag , The Use of Simulators for Training In-Flight and Emergency Procedures in AGARD-AG-248 (Neuilly-Sur...17 Edward E. Eddowes and Wayne L. Waag , The Use of Simulators for Training In-Flight and Emergency Procedures in AGARD-AG-248 (Neuilly-Sur-Seine

  3. 40 CFR 98.248 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... GREENHOUSE GAS REPORTING Petrochemical Production § 98.248 Definitions. Except as specified in this section... process: the petrochemical, recovered byproducts, and liquid organic wastes that are not incinerated...

  4. 40 CFR 98.248 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GREENHOUSE GAS REPORTING Petrochemical Production § 98.248 Definitions. Except as specified in this section... process: the petrochemical, recovered byproducts, and liquid organic wastes that are not incinerated...

  5. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  6. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  7. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  8. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  9. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  10. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... PROCEDURES Measurement Instruments Flow-Related Measurements § 1065.248 Gas divider. (a) Application. You may...

  11. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Specifications for Dairy Plants Approved for USDA Inspection and Grading Service 1 Requirements for Finished Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial...

  12. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Specifications for Dairy Plants Approved for USDA Inspection and Grading Service 1 Requirements for Finished Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial...

  13. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Specifications for Dairy Plants Approved for USDA Inspection and Grading Service 1 Requirements for Finished Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial...

  14. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  15. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  16. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  17. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  18. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  19. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  20. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  1. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  2. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  3. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and...” or “Act”), regulates the use of consumer information received from an affiliate to make marketing...

  4. Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wibmer, Constantinos Kurt; Gorman, Jason; Ozorowski, Gabriel

    A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41. Despite low maximum inhibition plateaus, often below 50% inhibitory concentrations, the breadth of CAP248-2B significantly correlated with donor plasma. Site-directed mutagenesis, X-ray crystallography, and negative-stainmore » electron microscopy 3D reconstructions revealed how CAP248-2B recognizes a cleavage-dependent epitope that includes the gp120 C terminus. While this epitope is distinct, it overlapped in parts of gp41 with the epitopes of broadly neutralizing antibodies PGT151, VRC34, 35O22, 3BC315, and 10E8. CAP248-2B has a conformationally variable paratope with an unusually long 19 amino acid light chain third complementarity determining region. Two phenylalanines at the loop apex were predicted by docking and mutagenesis data to interact with the viral membrane. Neutralization by CAP248-2B is not dependent on any single glycan proximal to its epitope, and low neutralization plateaus could not be completely explained by N- or O-linked glycosylation pathway inhibitors, furin co-transfection, or pre-incubation with soluble CD4. Viral escape from CAP248-2B involved a cluster of rare mutations in the gp120-gp41 cleavage sites. Simultaneous introduction of these mutations into heterologous viruses abrogated neutralization by CAP248-2B, but enhanced neutralization sensitivity to 35O22, 4E10, and 10E8 by 10-100-fold. Altogether, this study expands the region of the HIV-1 gp120-gp41 quaternary interface that is a target for broadly neutralizing antibodies and identifies a set of mutations in the gp120 C terminus that exposes the membrane-proximal external region of gp41, with potential utility in HIV vaccine design.« less

  5. Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

    PubMed Central

    Elliott, Debra H.; Rouelle, Julie; Smira, Ashley; Ndabambi, Nonkululeko; Druz, Aliaksandr; Williamson, Carolyn

    2017-01-01

    A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41. Despite low maximum inhibition plateaus, often below 50% inhibitory concentrations, the breadth of CAP248-2B significantly correlated with donor plasma. Site-directed mutagenesis, X-ray crystallography, and negative-stain electron microscopy 3D reconstructions revealed how CAP248-2B recognizes a cleavage-dependent epitope that includes the gp120 C terminus. While this epitope is distinct, it overlapped in parts of gp41 with the epitopes of broadly neutralizing antibodies PGT151, VRC34, 35O22, 3BC315, and 10E8. CAP248-2B has a conformationally variable paratope with an unusually long 19 amino acid light chain third complementarity determining region. Two phenylalanines at the loop apex were predicted by docking and mutagenesis data to interact with the viral membrane. Neutralization by CAP248-2B is not dependent on any single glycan proximal to its epitope, and low neutralization plateaus could not be completely explained by N- or O-linked glycosylation pathway inhibitors, furin co-transfection, or pre-incubation with soluble CD4. Viral escape from CAP248-2B involved a cluster of rare mutations in the gp120-gp41 cleavage sites. Simultaneous introduction of these mutations into heterologous viruses abrogated neutralization by CAP248-2B, but enhanced neutralization sensitivity to 35O22, 4E10, and 10E8 by 10-100-fold. Altogether, this study expands the region of the HIV-1 gp120-gp41 quaternary interface that is a target for broadly neutralizing antibodies and identifies a set of mutations in the gp120 C terminus that exposes the membrane-proximal external region of gp41, with potential utility in HIV vaccine design. PMID:28076415

  6. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  7. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  8. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  9. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  10. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  11. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  12. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  13. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  14. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  15. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  16. 248 mine, Terlingua quicksilver district, Brewster County, Texas

    USGS Publications Warehouse

    Yates, Robert G.; Thompson, George A.

    1944-01-01

    The 248 quicksilver mine is in Section 248, Block G-4, 2 miles east of Terlingua and 86 miles by dirt road from Alpine, Tex., the nearest railway shipping point (see accompanying maps). Cinnabar, the quicksilver mineral, was discovered before 1902. By 1934 there were only about 700 feet of subsurface workings, but in recent years the Esperado Mining Co., which has the property under lease, has greatly extended exploratory workings and has built a Herreshoff furnace rated at 40 tons per day. At the present time there are 1 1/3 miles of underground workings and 800 feet of surface trenches.

  17. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  18. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  19. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  20. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  1. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  2. Ferroportin (Q248H) mutations in African families with dietary iron overload.

    PubMed

    McNamara, Lynne; Gordeuk, Victor R; MacPhail, A Patrick

    2005-12-01

    Dietary iron overload found in sub-Saharan Africa might be caused by an interaction between dietary iron and an iron-loading gene. Caucasian people with ferroportin gene mutations have iron overload histologically similar to that found in African patients with iron overload. Ferroportin is also implicated in the hypoferremic response to inflammation. The prevalence of the ferroportin Q248H mutation, unique to African people, and its association with dietary iron overload, mean cell volume (MCV) and C-reactive protein (CRP) were examined in 19 southern African families. Polymerase chain reaction (PCR) and restriction enzyme digestion were used to identify the Q248H mutation. Statistical analysis was carried out to correlate the presence of the mutation with markers of iron overload and inflammation. We identified three (1.4%) Q248H homozygotes and 53 (24.1%) heterozygotes in the families examined in the present study. There was no increased prevalence of the mutation in index subjects or their families. Logistic regression showed significantly higher serum ferritin concentrations with the mutation. The mean cell volume (MCV) was significantly lower, and the serum CRP significantly higher in subjects who carried the mutation. The present study of 19 families with African iron overload failed to show evidence that the ferroportin (Q248H) mutation is responsible for the condition. Logistic regression, correcting for factors influencing iron status, did show increased ferritin levels in individuals with the mutation. The strong association with low MCV suggests the possibility that the ferroportin (Q248H) mutation might interfere with iron supply, whereas the elevated serum CRP might indicate that the ferroportin mutation influences the inflammatory response in African populations. Copyright 2005 Blackwell Publishing Asia Pty Ltd.

  3. [Lactic acid inhibits the formation of semen-derived amyloid fibrils].

    PubMed

    Li, Jin-Qing; Song, Ya-Li; Xun, Tian-Rong; Tan, Sui-Yi; Liu, Shu-Wen

    2017-07-20

    To investigate the inhibitory effect of lactic acid on semen-derived amyloid (SEVI) fibril formation. PAP248-286 (2 mg/mL) was incubated with 4.0, 2.0, 1.0, 0.5, 0.25, and 0.125 mg/mL of lactic acid. After incubation for different times, aliquots were drawn from each sample for Thioflavin T (ThT) and Congo red staining to monitor semen-derived amyloid fibril formation. The β sheet structure formation of PAP248-286 was measured by circular dichroism spectrum, and the morphology of amyloid fibrils incubated with or without lactic acid was observed with transmission electron microscopy (TEM). The enhancing effect of amyloid fibril incubated with lactic acid at different time points was determined using virus infection assay. PAP248-286 (2 mg/mL) was incubated with dilutions of vaginal secretion from healthy women, and amyloid fibril formation was detected with ThT and Congo red staining. Lactic acid inhibited SEVI fibril formation in a dose-dependent manner in vitro. Lactic acid at 0.5 mg/mL completely inhibited 2 mg/mL SEVI fibril formation within 48 h. After incubation for 48 h, lactic acid at 1 mg/mL inhibited the formation of β-sheet structure of SEVI (2 mg/mL) and completely inhibited 2 mg/mL PAP248-286 aggregation as observed with TEM. In the presence of lactic acid, PAP248-286 lost the ability to enhance virus infection. Vaginal secretion inhibited SEVI fibril formation in a dose-dependent manner, and virtually no SEVI fibril occurred after incubation of 2 mg/mL PAP248-286 with 67% vaginal secretion. Lactic acid inhibits SEVI fibril formation in vitro.

  4. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  5. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  6. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  7. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  8. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  9. Theoretical study on production cross sections of exotic actinide nuclei in multinucleon transfer reactions

    NASA Astrophysics Data System (ADS)

    Zhu, Long

    2017-12-01

    Within the dinuclear system (DNS) model, the multinucleon transfer reactions 129,136Xe + 248Cm, 112Sn + 238U, and 144Xe + 248Cm are investigated. The production cross sections of primary fragments are calculated with the DNS model. By using a statistical model, we investigate the influence of charged particle evaporation channels on production cross sections of exotic nuclei. It is found that for excited neutron-deficient nuclei the charged particle evaporation competes with neutron emission and plays an important role in the cooling process. The production cross sections of several exotic actinide nuclei are predicted in the reactions 112Sn + 238U and 136,144Xe + 248Cm. Considering the beam intensities, the collisions of 136,144Xe projectiles with a 248Cm target for producing neutron-rich nuclei with Z=92-96 are investigated. Supported by National Natural Science Foundation of China (11605296) and Natural Science Foundation of Guangdong Province, China (2016A030310208)

  10. Cl2O photochemistry: ultraviolet/vis absorption spectrum temperature dependence and O(3P) quantum yield at 193 and 248 nm.

    PubMed

    Papanastasiou, Dimitrios K; Feierabend, Karl J; Burkholder, James B

    2011-05-28

    The photochemistry of Cl(2)O (dichlorine monoxide) was studied using measurements of its UV/vis absorption spectrum temperature dependence and the O((3)P) atom quantum yield, Φ(Cl(2)O)(O)(λ), in its photolysis at 193 and 248 nm. The Cl(2)O UV/vis absorption spectrum was measured over the temperature range 201-296 K between 200 and 500 nm using diode array spectroscopy. Cl(2)O absorption cross sections, σ(Cl(2)O)(λ,T), at temperatures <296 K were determined relative to its well established room temperature values. A wavelength and temperature dependent parameterization of the Cl(2)O spectrum using the sum of six Gaussian functions, which empirically represent transitions from the ground (1)A(1) electronic state to excited states, is presented. The Gaussian functions are found to correlate well with published theoretically calculated vertical excitation energies. O((3)P) quantum yields in the photolysis of Cl(2)O at 193 and 248 nm were measured using pulsed laser photolysis combined with atomic resonance fluorescence detection of O((3)P) atoms. O((3)P) quantum yields were measured to be 0.85 ± 0.15 for 193 nm photolysis at 296 K and 0.20 ± 0.03 at 248 nm, which was also found to be independent of temperature (220-352 K) and pressure (17 and 28 Torr, N(2)). The quoted uncertainties are at the 2σ (95% confidence) level and include estimated systematic errors. ClO radical temporal profiles obtained following the photolysis of Cl(2)O at 248 nm, as reported previously in Feierabend et al. [J. Phys. Chem. A 114, 12052, (2010)], were interpreted to establish a <5% upper-limit for the O + Cl(2) photodissociation channel, which indicates that O((3)P) is primarily formed in the three-body, O + 2Cl, photodissociation channel at 248 nm. The analysis also indirectly provided a Cl atom quantum yield of 1.2 ± 0.1 at 248 nm. The results from this work are compared with previous studies where possible. © 2011 American Institute of Physics

  11. Final Report for Contract N00014-86-C-0598 (Thermo Electron Technologies Corporation)

    DTIC Science & Technology

    1989-12-28

    At least 20 A/cm2 were observed at 193 nm. 248 nm (KrF) and 308 (XeCl). Beam brightness appears to be a minimum of 4 x 105 A/cm 2 -rad 2 at 248 nm...governed by the envelope equation3, d2r K b 0 dz (4) For a weakly relativistic beam. e J o r0 2 2 Co 0Mo (yac) 3 (5) where Jo is the beam current...correspond to laser wavotengths of the present study, preliminary measurement for ArF given by x .1 pattern ot spots on the phosphor screen for 248 nm

  12. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  13. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24.... Russell National School Lunch Act and the Child Nutrition Act of 1966 (42 U.S.C. 1786). [59 FR 11517, Mar...

  14. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24.... Russell National School Lunch Act and the Child Nutrition Act of 1966 (42 U.S.C. 1786). [59 FR 11517, Mar...

  15. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  16. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  17. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24.... Russell National School Lunch Act and the Child Nutrition Act of 1966 (42 U.S.C. 1786). [59 FR 11517, Mar...

  18. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  19. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  20. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.120 Definitions. As used in... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... company means the power to exercise a controlling influence over the management or policies of a company...

  1. High throughput virtual screening and in silico ADMET analysis for rapid and efficient identification of potential PAP248-286 aggregation inhibitors as anti-HIV agents

    NASA Astrophysics Data System (ADS)

    Malik, Ruchi; Bunkar, Devendra; Choudhary, Bhanwar Singh; Srivastava, Shubham; Mehta, Pakhuri; Sharma, Manish

    2016-10-01

    Human semen is principal vehicle for transmission of HIV-1 and other enveloped viruses. Several endogenous peptides present in semen, including a 39-amino acid fragments of prostatic acid phosphatase (PAP248-286) assemble into amyloid fibrils named as semen-derived enhancer of viral infection (SEVI) that promote virion attachment to target cells which dramatically enhance HIV virus infection by up to 105-fold. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound, is the major catechin found in green tea which disaggregates existing SEVI fibers, and inhibits the formation of SEVI fibers. The aim of this study was to screen a number of relevant polyphenols to develop a rational approach for designing PAP248-286 aggregation inhibitors as potential anti-HIV agents. The molecular docking based virtual screening results showed that polyphenolic compounds 2-6 possessed good docking score and interacted well with the active site residues of PAP248-286. Amino acid residues of binding site namely; Lys255, Ser256, Leu258 and Asn265 are involved in binding of these compounds. In silico ADMET prediction studies on these hits were also found to be promising. Polyphenolic compounds 2-6 identified as hits may act as novel leads for inhibiting aggregation of PAP248-286 into SEVI.

  2. 17 CFR 248.16 - Protection of Fair Credit Reporting Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Relation to Other Laws; Effective Date § 248.16 Protection of Fair Credit... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Protection of Fair Credit...

  3. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.4 Initial privacy notice to consumers... section; and (2) Consumer. A consumer, before you disclose any nonpublic personal information about the...

  4. 31 CFR 248.2 - Delegation of authority to issue substitute checks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Delegation of authority to issue... IN DEPOSITARY BANKS IN FOREIGN COUNTRIES OR UNITED STATES TERRITORIES OR POSSESSIONS Delegation of Authority § 248.2 Delegation of authority to issue substitute checks. Pursuant to authority contained in...

  5. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the consumer. (2) Continuing relationship—(i) In general. If the consumer establishes a continuing relationship...

  6. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective... subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1, 2010. For...

  7. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... on Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a... this subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1...

  8. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.122... notice but not other types of affiliates covered by the notice, electing to prohibit marketing... before the company's affiliates may make marketing solicitations to the consumer using eligibility...

  9. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective... subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1, 2010. For...

  10. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective... subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1, 2010. For...

  11. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective date. This subpart is effective September 10, 2009. (b) Mandatory compliance date. Compliance with this... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Effective date, compliance...

  12. 42 CFR 403.248 - Administrative review of CMS determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Administrative review of CMS determinations. 403... Certification Program: General Provisions § 403.248 Administrative review of CMS determinations. (a) This section provides for administrative review if CMS determines— (1) Not to certify a policy; or (2) That a...

  13. Swift follow-up of the flaring blazar OJ 248

    NASA Astrophysics Data System (ADS)

    D'Ammando, F.; Orienti, M.

    2012-10-01

    Following the gamma-ray flaring activity of the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) detected by Fermi LAT starting from 2012 September 23 (ATel #4421) a Swift target of opportunity observation was performed on September 28.

  14. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.126 Delivery... Internet Web site at which the consumer obtained a product or service electronically and requires the... by e-mail from the affiliate providing the notice; or (3) Posts the notice on an Internet Web site...

  15. 14 CFR 248.4 - Time for filing reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) ECONOMIC REGULATIONS SUBMISSION OF AUDIT REPORTS § 248.4 Time for filing reports. The report required by... the appropriate periodic BTS Form 41 Report, filed for the 12-month period covered by the audit report, or the date the accountant submits its audit report to the air carrier, whichever is later. [ER-1351...

  16. 11. Photographic copy of construction drawing, dated September 20, 1930, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of construction drawing, dated September 20, 1930, Construction Division Office of the Quartermaster General in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-1548, SDO 133 (SECTIONS, EXTERIOR DETAILS) - Selfridge Field, Building Nos. 248, 252 & 254, 248 Birch Street & 252, 254 Wagner Street, Mount Clemens, Macomb County, MI

  17. 13. Photographic copy of construction drawing, dated July 29, 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photographic copy of construction drawing, dated July 29, 1932, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2512, SDO 132 (VESTIBULE DETAILS) - Selfridge Field, Building Nos. 248, 252 & 254, 248 Birch Street & 252, 254 Wagner Street, Mount Clemens, Macomb County, MI

  18. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... business relationship with the consumer. (b) Making marketing solicitations—(1) In general. For purposes of... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.121...

  19. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the... but not other types of affiliates covered by the notice, electing to prohibit marketing solicitations...

  20. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.121 Affiliate marketing opt out and exceptions. (a) Initial notice and opt out requirement—(1) In general. You...

  1. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  2. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  3. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.121 Affiliate marketing opt out and exceptions. (a) Initial notice and opt out requirement—(1) In...

  4. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  5. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  6. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the... but not other types of affiliates covered by the notice, electing to prohibit marketing solicitations...

  7. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  8. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.121 Affiliate marketing opt out and exceptions. (a) Initial notice and opt out requirement—(1) In general. You...

  9. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  10. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the... but not other types of affiliates covered by the notice, electing to prohibit marketing solicitations...

  11. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  12. 17 CFR 248.2 - Model privacy form: rule of construction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Model privacy form: rule of... Safeguarding Personal Information § 248.2 Model privacy form: rule of construction. (a) Model privacy form. Use of the model privacy form in Appendix A to Subpart A of this part, consistent with the instructions...

  13. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  14. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  15. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  16. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  17. 12 CFR 303.248 - Truth in Lending Act-Relief from reimbursement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Truth in Lending Act-Relief from reimbursement... PRACTICE FILING PROCEDURES Other Filings § 303.248 Truth in Lending Act—Relief from reimbursement. (a) Scope. This section applies to requests for relief from reimbursement pursuant to the Truth in Lending...

  18. Kinetics of UV laser radiation defects in high performance glasses

    NASA Astrophysics Data System (ADS)

    Natura, U.; Feurer, T.; Ehrt, D.

    2000-05-01

    High purity fluoride phosphate glasses are attractive candidates as UV transmitting materials. The calculated values for the ultraviolet resonance wavelength are comparable with those of pure silica glass or fluoride single crystal CaF2. The formation of radiation-induced defect centers leads to additional absorption bands in the VUV-UV-vis range. The damage and the healing behavior by lamps and lasers are investigated in dependence on phosphate content and the content of impurities, mainly transition metals. Experiments were carried out using pulsed lasers with a duration of femto- and nanoseconds at a wavelength of 248 nm. The initial slope of the induced absorption shows a nonlinear dependence on the pulse energy density. Resonant and non-resonant two-photon mechanisms were observed. Two-photon-absorption coefficients at 248 nm for samples with different phosphate contents were measured. Models of the kinetics of the radiation-induced defects were developed. The inclusion of energy transfer was necessary to explain the difference in the damage behavior for nanosecond (248 nm, 193 nm) and femtosecond (248 nm) laser pulses.

  19. Epidemiological features of gastroenteropancreatic neuroendocrine tumors in Chengdu city with a population of 14 million based on data from a single institution.

    PubMed

    Guo, Lin-Jie; Wang, Chun-Hui; Tang, Cheng-Wei

    2016-09-01

    Recent studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the United States as well as the European studies demonstrate an increasing GEP-NETs incidence. Most information on the epidemiology of neuroendocrine tumors comes from western countries. However, the epidemiological profile of GEP-NETs in West China is still unclear. The aim of study was to reflect the regional features of GEP-NETs in Chengdu city of West China based on data from a single institution. West China Hospital (WCH), the largest university hospital located in Chengdu (West China) with population of 14.04 million, has established a serial of databases in recent years. According to the data from Medical Records Section of WCH and Chengdu Health Bureau, the total patients per year in WCH covered about 25.6-28% patients of Chengdu city during the 5 years. Therefore, we have used GEP-NETs diagnosed in WCH from 2009 to 2013 to reflect the regional epidemiological profile of GEP-NETs. GEP-NETs proportion in WCH increased 1.6-folds during past 5 years from 1.28/10(5) to 2.03/10(5) , P < 0.05. The average duration of symptom before diagnosis was 16.8 months. About 46.6% (115/248) of GEP-NETs were metastatic. Seventy-seven percent (190/248) of patients were over 40 years. Proportions of GEP-NETs from primary sites were rectum 30.6% (76/248), pancreas 23.4% (58/248), gastric 13.3% (33/248) and esophagus 11.3% (28/248). Proportions of insulinoma, vipoma and nonfunctional pancreatic neuroendocrine tumors (P-NETs) were 43.1% (25/58), 1.7% (1/58) and 55.2% (32/58) separately in the P-NETs. There is a distinct epidemiologic profile between West China and western countries based on a single institution data. The delayed diagnosis reflects inadequate disease awareness of GEP-NETs and paucity of research funding. © 2016 John Wiley & Sons Australia, Ltd.

  20. Settlement induction of Acropora palmata planulae by a GLW-amide neuropeptide

    NASA Astrophysics Data System (ADS)

    Erwin, P. M.; Szmant, A. M.

    2010-12-01

    Complex environmental cues dictate the settlement of coral planulae in situ; however, simple artificial cues may be all that is required to induce settlement of ex situ larval cultures for reef re-seeding and restoration projects. Neuropeptides that transmit settlement signals and initiate the metamorphic cascade have been isolated from hydrozoan taxa and shown to induce metamorphosis of reef-building Acropora spp. in the Indo-Pacific, providing a reliable and efficient settlement cue. Here, the metamorphic activity of six GLW-amide cnidarian neuropeptides was tested on larvae of the Caribbean corals Acropora palmata, Montastraea faveolata and Favia fragum. A. palmata planulae were induced to settle by the exogenous application of the neuropeptide Hym-248 (concentrations ≥1 × 10-6 M), achieving 40-80% attachment and 100% metamorphosis of competent planulae (≥6 days post-fertilization) during two spawning seasons; the remaining neuropeptides exhibited no activity. Hym-248 exposure rapidly altered larval swimming behavior (<1 h) and resulted in >96% metamorphosis after 6 h. In contrast , M. faveolata and F. fragum planulae did not respond to any GLW-amides tested, suggesting a high specificity of neuropeptide activators on lower taxonomic scales in corals. Subsequent experiments for A. palmata revealed that (1) the presence of a biofilm did not enhance attachment efficiency when coupled with Hym-248 treatment, (2) neuropeptide-induced settlement had no negative effects on early life-history developmental processes: zooxanthellae acquisition and skeletal secretion occurred within 12 days, colonial growth occurred within 36 days, and (3) Hym-248 solutions maintained metamorphic activity following storage at room temperature (10 days), indicating its utility in remote field settings. These results corroborate previous studies on Indo-Pacific Acropora spp. and extend the known metamorphic activity of Hym-248 to Caribbean acroporids. Hym-248 allows for directed and reliable settlement of larval cultures and has broad applications to the study and rehabilitation of threatened Acropora populations in the Caribbean.

  1. 77 FR 63285 - Airworthiness Directives; Brantly International, Inc. Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ..., 2012. ADDRESSES: You may send comments by any of the following methods: Federal eRulemaking Docket: Go...-101, 248-202, or 248- 404, visually inspecting the M/R blade for a crack, nick, wrinkle, or bend..., wrinkle, bend, added hole (such as a drilled hole to stop the spread of a crack), extra rivet, or...

  2. 12. Photographic copy of construction drawing, dated June 7, 1933, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photographic copy of construction drawing, dated June 7, 1933, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2517, SDO 186 F41 (FLOOR PLAN) - Selfridge Field, Building Nos. 248, 252 & 254, 248 Birch Street & 252, 254 Wagner Street, Mount Clemens, Macomb County, MI

  3. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...”; (iii) A general description of the types of eligibility information that may be used to make marketing... make marketing solicitations to the consumer; (v) That the consumer's election will apply for the...

  4. Survey of United States Commercial Satellites in Geosynchronous Earth Orbit

    DTIC Science & Technology

    1994-09-01

    248 a. Imaging Sensors ...... ............ 248 (1) Return Beam Vidicon Camera . ... 249 (2) Scanners. ...... ............ 249 b. Nonimaging ...251 a. Imaging Microwave Sensors ......... .. 251 (1) Synthetic Aperture Radar . ... 251 b. Nonimaging Microwave Sensors ..... .. 252 (1) Radar...The stream of electrons travels alonq the axis oa the tube, constrained by focusing magnets, until it reaches the collector . Surrounding this electron

  5. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  6. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  7. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  8. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  9. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  10. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  11. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  12. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  13. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  14. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  15. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  16. 77 FR 26824 - Agency Information Collection; Activity Under OMB Review; Submission of Audit Reports-Part 248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Submission of Audit Reports.... SUPPLEMENTARY INFORMATION: OMB Approval No. 2138-0004. Title: Submission of Audit Reports--Part 248. Form No... having an annual audit must file a statement that no such audit has been performed. In lieu of the audit...

  17. 78 FR 36084 - Special Conditions: Cirrus Design Corporation Model SF50 Airplane; Function and Reliability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ...; Special Conditions No. 23-248-SC] Special Conditions: Cirrus Design Corporation Model SF50 Airplane... granting special conditions for the Cirrus Design Corporation model SF50 airplane. We are withdrawing... Special Condition No. 23-248- SC for the Cirrus Design Corporation new model SF50 ``Vision'' Jet. The SF50...

  18. Star formation in infrared bright and infrared faint starburst interacting galaxies

    NASA Technical Reports Server (NTRS)

    Lamb, Susan A.; Bushouse, Howard A.; Towns, John W.

    1990-01-01

    Short wavelength IUE spectra of Arp 248b and UGC 8315N are combined with optical spectra and interpreted using a combination of spectrum synthesis and spectral diagnostics to place constraints on the massive star populations of the central regions of these galaxies and to deduce information about the star formation histories in the last 10(exp 8) years. The authors find that both galaxies have substantial fractions of their optical light coming from massive stars and that Arp 248b may be dominated in the UV by WR stars. The UV spectra are dominated by radiation from evolved massive stars and the authors place and age on the burst in Arp 248b of a few tens of millions of years.

  19. Calling for a Truce on the Military Divorce Battlefield: A Proposal to Amend the USFSPA

    DTIC Science & Technology

    2001-04-01

    28 Silkwood v. Kerr-McGee Corp., 464 U.S. 238, 248 (1984). 7 preempting domestic relations law, the Supreme Court has held that "state interests...that field is pre-empted." Silkwood v. Kerr-McGee Corp., 464 U.S. 238, 248 (1984). Because Congress has occupied the field of military retirement

  20. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  1. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  2. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  3. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  4. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form of opt out notice to... Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt...

  5. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the Federal Reserve... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Authority, purpose, and scope. 265.1 Section... (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable it to effectively...

  6. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Pursuant to section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Authority, purpose, and scope. 265.1 Section... Federal Reserve Act (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable...

  7. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the Federal Reserve... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Authority, purpose, and scope. 265.1 Section... (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable it to effectively...

  8. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Pursuant to section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Authority, purpose, and scope. 265.1 Section... Federal Reserve Act (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable...

  9. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Pursuant to section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Authority, purpose, and scope. 265.1 Section... Federal Reserve Act (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable...

  10. Fast Facts: Recent Statistics from the Library Research Service, Nos. 248-255. March-December 2007

    ERIC Educational Resources Information Center

    Online Submission, 2007

    2007-01-01

    Issues 248 through 255 of "Fast Facts" from the Library Research Service present data gleaned from libraries in Colorado and across the nation. Topics addressed in these "Fast Facts" from 2007 include the library labor market, the benefits to libraries of using a statewide courier service, and the results of a patron survey at…

  11. 12 CFR 210.25 - Authority, purpose, and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... J) Funds Transfers Through Fedwire § 210.25 Authority, purpose, and scope. (a) Authority and purpose...), paragraph 14 of section 16 (12 U.S.C. 248(o)), and paragraphs (i) and (j) of section 11 (12 U.S.C. 248(i) and (j))—and other laws and has the force and effect of federal law. This subpart is not a funds...

  12. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What solid and liquid wastes and discharges...) § 250.248 What solid and liquid wastes and discharges information and cooling water intake information must accompany the DPP or DOCD? The following solid and liquid wastes and discharges information and...

  13. Detection of Toxoplasma gondii in the milk of naturally infected goats in the Northeast of Brazil.

    PubMed

    Bezerra, M J G; Kim, P C P; Moraes, É P B X; Sá, S G; Albuquerque, P P F; Silva, J G; Alves, B H L S; Mota, R A

    2015-08-01

    The aim of the present study was to detect the genomic DNA of Toxoplasma gondii in milk samples from naturally infected goats in the state of Pernambuco, (Brazil). In total, 248 blood serum samples were collected and processed from lactating goats and then submitted to a search for antibodies to T. gondii through the indirect immunofluorescence reaction. Samples with a score of 64 or more were considered positive. In total, 248 milk samples were collected and processed from the same group of goats in order to study the DNA of T. gondii using the polymerase chain reaction (PCR) technique. In the serum samples, 56/248 (22.58%) of the animals were positive, whereas the DNA of the parasite was detected in 15/248 (6.05%) of the milk samples. Five of these 15 samples were animals who were also positive in the serology. This study reports the first occurrence of the elimination of T. gondii from the milk of naturally infected goats in the north-east of Brazil. It is suggested that the consumption of in natura goat milk may constitute a potential risk to the health of milk consumers in this region. © 2013 Blackwell Verlag GmbH.

  14. Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products.

    PubMed

    Dhaneesha, M; Benjamin Naman, C; Krishnan, K P; Sinha, Rupesh Kumar; Jayesh, P; Joseph, Valsamma; Bright Singh, I S; Gerwick, William H; Sajeevan, T P

    2017-05-01

    After screening marine actinomycetes isolated from sediment samples collected from the Arctic fjord Kongsfjorden for potential anticancer activity, an isolate identified as Streptomyces artemisiae MCCB 248 exhibited promising results against the NCI-H460 human lung cancer cell line. H460 cells treated with the ethyl acetate extract of strain MCCB 248 and stained with Hoechst 33342 showed clear signs of apoptosis, including shrinkage of the cell nucleus, DNA fragmentation and chromatin condensation. Further to this treated cells showed indications of early apoptotic cell death, including a significant proportion of Annexin V positive staining and evidence of DNA damage as observed in the TUNEL assay. Amplified PKS 1 and NRPS genes involved in secondary metabolite production showed only 82% similarity to known biosynthetic genes of Streptomyces, indicating the likely production of a novel secondary metabolite in this extract. Additionally, chemical dereplication efforts using LC-MS/MS molecular networking suggested the presence of a series of undescribed tetraene polyols. Taken together, these results revealed that this Arctic S. artemisiae strain MCCB 248 is a promising candidate for natural products drug discovery and genome mining for potential anticancer agents.

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lin, C.T.

    Linear and nonlinear photochemistries of 1,4-diazabicyclo(2.2.2)octane (DABCO) are investigated at room temperature by using ArF (193 nm) and KrF (248 nm) lasers. With an unfocused beam geometry, DABCO vapor displays a strong fluorescence when excited at 248 nm, but it shows no detectable emission with 193-nm excitation. The linear photochemistry quantum yield for DABCO is determined as phi/sub p/(248nm) approx. 0.1 and phi/sub p/(193 nm) approx. 0.3. The main stable photochemical products are analyzed as C/sub 2/H/sub 4/ and C/sub 2/H/sub 2/ for 248- and 193-nm excitation, respectively. When focused beam excitation is used, both ArF and KrF lasers dissociatemore » DABCO molecules and give three strong radical emissions of CN*(B vector /sup 2/..sigma.. ..-->.. X vector /sup 2/ ..sigma../sup +/), CH*(A vector /sup 2/..delta.. ..-->.. X vector /sup 2/II), and C/sub 2/*(D vector /sup 3/II/sub g/ ..-->.. a vector /sup 3/II/sub u/). The time behavior, the laser power dependence, and the sample pressure dependence of these emissive radicals are examined. The possible mechanisms for the Rydberg state photochemistry of DABCO are discussed.« less

  16. Construction and Commissioning of A 248 m-long Beamline with X-ray Undulator Light Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Suzuki, Yoshio; Uesugi, Kentaro; Takimoto, Naoki

    2004-05-12

    A medium-length beamline with undulator source, BL20XU at SPring-8, was constructed, and opened to public use. The distance from source point to the end of the beamline is 248 m. By utilizing the long beam transport path, the beamline has advantages for experiment that requires high spatial coherence in hard X-ray regions.

  17. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Form of opt out notice to... Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt out notice under...

  18. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Form of opt out notice to... Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt out notice under...

  19. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Form of opt out notice to... Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt out notice under...

  20. R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series.

    PubMed

    Villalona, Seiichi; Glover-López, Guillermo; Ortega-García, Juan Antonio; Moya-Quiles, Rosa; Mondejar-López, Pedro; Martínez-Romero, Maria C; Rigabert-Montiel, Mariano; Pastor-Vivero, María D; Sánchez-Solís, Manuel

    2017-02-15

    Mutational combinations of the cystic fibrosis transmembrane conductance regulator, CFTR, gene have different phenotypic manifestations at the molecular level with varying clinical consequences for individuals possessing such mutations. Reporting cystic fibrosis transmembrane conductance regulator mutations is important in understanding the genotype-phenotype correlations and associated clinical presentations in patients with cystic fibrosis. Understanding the effects of mutations is critical in developing appropriate treatments for individuals affected with cystic fibrosis, non-classic cystic fibrosis, or cystic fibrosis transmembrane conductance regulator-related disorders. This is the first report of related individuals possessing the R248G missense cystic fibrosis transmembrane conductance regulator mutation and we present their associated clinical histories. All three patients are of Spanish descent. Deoxyribonucleic acid analysis revealed that all three siblings possessed a novel c.742A>G mutation, resulting in a p.Arg248Gly (R248G) amino acid change in exon 6 in trans with the known N1303K mutant allele. Case 1 patient is a 39-year-old infertile man presenting with congenital unilateral absence of the vas deferens and recurrent episodes of epigastric pain. Case 2 patient is a 32-year-old woman presenting with periods of infertility, two previous spontaneous abortions, recurrent epigastric pain, and recurrent pancreatitis. Case 3 patient is a 29-year-old woman presenting with recurrent pancreatitis and epigastric pain. We report the genotype-phenotype correlations and clinical manifestations of a novel R248G cystic fibrosis transmembrane conductance regulator mutation: congenital unilateral absence of the vas deferens in males, reduced female fertility, and recurrent acute pancreatitis. In addition, we discuss the possible functional consequences of the mutations at the molecular level.

  1. Time-dependent infrared emission following photodissociation of nitromethane and chloropicrin.

    PubMed

    Wade, Elisabeth A; Reak, Kristina E; Li, Sissi L; Clegg, Samuel M; Zou, Peng; Osborn, David L

    2006-04-06

    Nitromethane (CH(3)NO(2)) and its chlorinated analogue, chloropicrin (CCl(3)NO(2)), were photolyzed at 193, 248, and 266 nm, and the products were observed by time-dependent Fourier transform infrared emission spectroscopy. At 193 and 248 nm, the primary photodissociation pathway for nitromethane was cleavage of the C-N bond to produce CH(3) + NO(2)(A (2)B(2)). At 266 nm, weak emission was observed following photodissociation of nitromethane, but an infrared spectrum could not be obtained. The photodissociation of chloropicrin at 193 nm produced the analogous product channel CCl(3) + NO(2)(A (2)B(2)) in addition to several other product channels. At 248 and 266 nm, only CCl(3) + NO(2)(A (2)B(2)) was observed. The production of phosgene (CCl(2)O) from chloropicrin photodissociation was not observed in this study.

  2. High Performance Organic Materials and Devices

    DTIC Science & Technology

    2006-03-31

    on this material exhibited external quantum efficiency of 2.48% and electroluminescence efficiency as high as 3.33 cd/A. 15. SUBJECT TERMS 16...International de L’Eclairage coordinate at (0.164, 0.188). The external quantum efficiency of 2.48% and electroluminescence efficiency as high as 3.33 cd...more than 90% absorption in active layer, and highly balanced carrier transport. 4 5. High efficient blue- electroluminescence device shows maximum

  3. 50 CFR 85.21 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... May 1 of the year preceding that fiscal year (e.g., May 1, 1995 for FY 1996). [59 FR 11206, Mar. 10... fish restoration fax number 1 503-231-6128 503-231-6996 2 505-248-7465 505-248-7471 3 612-713-5130 612-713-5290 4 404-679-4159 404-679-4160 5 413-253-8508 413-253-8487 6 303-236-4411 303-236-8192 7 907-786...

  4. 50 CFR 85.21 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... May 1 of the year preceding that fiscal year (e.g., May 1, 1995 for FY 1996). [59 FR 11206, Mar. 10... fish restoration fax number 1 503-231-6128 503-231-6996 2 505-248-7465 505-248-7471 3 612-713-5130 612-713-5290 4 404-679-4159 404-679-4160 5 413-253-8508 413-253-8487 6 303-236-4411 303-236-8192 7 907-786...

  5. 17 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 248 Forms

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... A of Part 248 Forms A. Any person may view and print this form at: http://www.sec.gov/about/forms... form, as appropriate. 2. The Contents of the Model Privacy Form The model form consists of two pages, which may be printed on both sides of a single sheet of paper, or may appear on two separate pages...

  6. Search for Cm-248 in the early solar system

    NASA Technical Reports Server (NTRS)

    Lavielle, B.; Marti, K.; Pellas, P.; Perron, C.

    1992-01-01

    Possible evidence for the presence of Cm-248 in the early solar system was reported from fission gas studies (Rao and Gopalan, 1973) and recently from studies of very high nuclear track densities (not less than 5 x 10 exp 8/sq cm) in the merrillite of the H4 chondrite Forest Vale (F.V.) (Pellas et al., 1987). We report here an analysis of the isotopic abundances of xenon in F.V. phosphates and results of track studies in phosphate/pyroxene contacts. The fission xenon isotopic signature clearly identifies Pu-244 as the extinct progenitor. We calculate an upper limit Cm-248/Pu-244 to be less than 0.0015 at the beginning of Xe retention in F.V. phosphates. This corresponds to an upper limit of the ratio Cm-248/U-235 of not greater than 5 x 10 exp -5 further constraining the evidence for any late addition of freshly synthesized actinide elements just prior to solar system formation. The fission track density observed after annealing the phosphates at 290C (1 hr, which essentially erases spallation recoil tracks) is also in agreement with the Pu-244 abundance inferred from fission Xe. The spallation recoil tracks produced during the 76 Ma cosmic-ray exposure account for the very high track density in merrillites.

  7. ksc-84pc-248

    NASA Image and Video Library

    2013-10-19

    KSC-84PC-248 (For release Aug. 27, 1984) --- The Continuous Flow Electrophoresis System (CFES) is being installed in the middeck of the Orbiter Discovery in preparation for the flight of mission STS-41D in June. The CFES, originating from the McDonnell Douglas Astronautics Co. includes a fluid systems module, and experiment control and monitoring module, a sample storage module and a pump/accumulator package along with miscellaneous equipment stored in a middeck locker. Photo credit: NASA

  8. Influence of laser wavelength on two-dimensional carbon nanosheet formation from laser-induced exfoliation of naphthalene

    NASA Astrophysics Data System (ADS)

    Qian, Min; Niu, Yue Ping; Gong, Shang Qing

    2018-01-01

    Pulsed Nd:YAG (532 nm) and Excimer (248 nm) lasers were employed to produce freestanding, two-dimensional (2D), carbon nanosheets (CNSs) from naphthalene, through laser-induced exfoliation. The polymer-to-carbon transition was investigated in terms of laser wavelengths, fluences, as well as target preparations. Continuous and porous CNSs of several nanometers in thickness and micrometers in size were obtained from 532 and 248 nm pulsed laser exfoliation of spin-coated naphthalene films, respectively. The porous morphology is ascribed to the photon-induced dissociation of chemical bonds dominated in 248 nm laser interaction with ablated naphthalene. With the increase of laser fluences from 1 to 5 J cm-2, amorphous carbon and ultrathin CNS structures were obtained in sequence. This work revealed a general mechanism of producing 2D structured carbon materials from pulsed laser exfoliation.

  9. Photodissociation of ethylbenzene and n-propylbenzene in a molecular beam

    NASA Astrophysics Data System (ADS)

    Huang, Cheng-Liang; Jiang, Jyh-Chiang; Lee, Yuan T.; Ni, Chi-Kung

    2002-10-01

    The photodissociation of jet-cooled ethylbenzene and n-propylbenzene at both 193 and 248 nm was studied using vacuum ultraviolet photoionization/multimass ion imaging techniques. The photofragment translational energy distributions from both the molecules obtained at 193 nm show that the probability of portioning energy to product translational energy decreases monotonically with increasing translational energy. They indicate that the dissociation occurs from the ground electronic state. However, the photofragment translational energy distributions from both molecules obtained at 248 nm contain a fast and a slow component. 75% of ethylbenzene and 80% of n-propylbenzene following the 248 nm photoexcitation dissociate from electronic excited state, resulting in the fast component. The remaining 25% of ethylbenzene and 20% of n-propylbenzene dissociate through the ground electronic state, giving rise to the slow component. A comparison with an ab initio calculation suggests that the dissociation from the first triplet state corresponds to the fast component in translational energy distribution.

  10. Molecular beam studies of stratospheric photochemistry

    NASA Astrophysics Data System (ADS)

    Moore, Teresa Anne

    1998-12-01

    Photochemistry of chlorine oxide containing species plays a major role in stratospheric ozone depletion. This thesis discusses two photodissociation studies of the key molecules ClONO2 and ClOOCl which were previously thought to only produce Cl-atom (ozone depleting) products at wavelengths relevant to the stratosphere. The development of a molecular beam source of ClOOCl and the photodissociation dynamics of the model system Cl2O are also discussed. In the first chapter, the photochemistry of ClONO2 is examined at 308 nm using the technique of photofragment translational spectroscopy. Two primary decomposition pathways, leading to Cl + NO3 and ClO + NO2, were observed, with a lower limit of 0.33 for the relative yield of ClO. The angular distributions for both channels were anisotropic, indicating that the dissociation occurs within a rotational period. Chapter two revisits the photodissociation dynamics of Cl2O at 248 and 308 nm, on which we had previously reported preliminary findings. At 248 nm, three distinct dissociation pathways leading to Cl + ClO products were resolved. At 308 nm, the angular distribution was slightly more isotropic that previously reported, leaving open the possibility that Cl2O excited at 308 nm lives longer than a rotational period. Chapter three describes the development and optimization of a molecular beam source of ClOOCl. We utilized pulsed laser photolysis of ClA2O to generate ClO radicals, and cooled the cell to promote three body recombination to form ClOOCl. The principal components in the beam were Cl2, Cl2O, and ClOOCl. In the fourth chapter, the photodissociation dynamics of ClOOCl are investigated at 248 and 308 nm. We observed multiple dissociation pathways which produced ClO + ClO and 2Cl + O2 products. The relative Cl:ClO product yields are 1.0:0.13 and 1.0:0.20 for ClOOCl photolysis at 248 and 308 nm, respectively. The upper limit for the relative yield of the ClO + ClO channel was 0.19 at 248 nm and 0.31 at 308 nm. These results substantially confirm the current assumption but decrease somewhat the efficiency of the ClOOCl ozone-depleting catalytic cycle. At 248 nm, ClOOCl photolysis exhibited novel dissociation dynamics which appeared to depend on the symmetry of the excited state.

  11. SULFUR- AND SILICON-BEARING MOLECULES IN PLANETARY NEBULAE: THE CASE OF M2-48

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edwards, J. L.; Ziurys, L. M., E-mail: lziurys@email.arizona.edu

    Molecular-line observations of the bipolar planetary nebula (PN) M2-48 have been conducted using the Sub-Millimeter Telescope and the 12 m antenna of the Arizona Radio Observatory at 1, 2, and 3 mm. M2-48 is estimated to be ∼4800 yr old, midway through the PN evolutionary track. SiO and SO{sub 2} were detected in this source—the first identification of either molecule in a PN. CN, HCN, HNC, CS, SO, HCO{sup +}, N{sub 2}H{sup +}, and several {sup 13}C isotopologues such as {sup 13}CN, H{sup 13}CN, and H{sup 13}CO{sup +} were also observed toward this object. A radiative transfer analysis of multiplemore » SiO transitions indicates a gas kinetic temperature of T {sub K} ∼ 55 K and a density of n(H{sub 2}) ∼ 9 × 10{sup 5} cm{sup –3} in M2-48, in agreement with previous CS and CO modeling. After CO, CN, and SO were found to be the most prevalent molecules in this nebula, with fractional abundances, relative to H{sub 2}, of f ∼ 3.8 × 10{sup –7} and 2.4 × 10{sup –7}, respectively. SO{sub 2} and HCN are also abundant, with f ∼ 1.2 × 10{sup –7}, indicating an [SO]/[SO{sub 2}] ratio of ∼2. Relatively high ion abundances were measured in M2-48 as well, with f ∼ 10{sup –7} for both HCO{sup +} and N{sub 2}H{sup +}. An [HCN]/[HNC] ratio of ∼2 was determined, as typically observed in other PNe, independent of age. The high abundances of SO and SO{sub 2}, along with the presence of SiO with f ∼ 2.9 × 10{sup –8}, suggest O/C > 1 in this source; furthermore, the prevalence of CN and N{sub 2}H{sup +} indicates nitrogen enrichment. The {sup 12}C/{sup 13}C ratio of ∼3 in the nebula was also established. These factors indicate hot-bottom burning occurred in the progenitor star of M2-48, suggesting an initial mass > 4 M {sub ☉}.« less

  12. Combating Terrorism Within Local Policing Through Crime Reduction: Using Real-Time, Situational Awareness Within a Distributed Common Operating Picture to Combat all Crime and Terrorism V2I2SION Process and SAFECOP Pilot Project

    DTIC Science & Technology

    2013-03-01

    Occurred on: Jul-07-2011 (Tbu.) 248 Approved on: Jul-07-2011 (Tbu.) by: 42505 - BAXTER, ROBERT M Report submitted by: 45158 - CHARBONNEAU , PETER A...Text Page(s) Document: CASE SUM:MARY Author: 45158- CHARBONNEAU , PETER A Subject: CASE SUM:MARY Related date/time: Jul-07-2011 (Tbu.) 248 On the

  13. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.

    PubMed

    Huang, Kai-Fa; Wang, Yu-Ruei; Chang, En-Cheng; Chou, Tsung-Lin; Wang, Andrew H-J

    2008-04-01

    QCs (glutaminyl cyclases; glutaminyl-peptide cyclotransferases, EC 2.3.2.5) catalyse N-terminal pyroglutamate formation in numerous bioactive peptides and proteins. The enzymes were reported to be involved in several pathological conditions such as amyloidotic disease, osteoporosis, rheumatoid arthritis and melanoma. The crystal structure of human QC revealed an unusual H-bond (hydrogen-bond) network in the active site, formed by several highly conserved residues (Ser(160), Glu(201), Asp(248), Asp(305) and His(319)), within which Glu(201) and Asp(248) were found to bind to substrate. In the present study we combined steady-state enzyme kinetic and X-ray structural analyses of 11 single-mutation human QCs to investigate the roles of the H-bond network in catalysis. Our results showed that disrupting one or both of the central H-bonds, i.e., Glu(201)...Asp(305) and Asp(248)...Asp(305), reduced the steady-state catalysis dramatically. The roles of these two COOH...COOH bonds on catalysis could be partly replaced by COOH...water bonds, but not by COOH...CONH(2) bonds, reminiscent of the low-barrier Asp...Asp H-bond in the active site of pepsin-like aspartic peptidases. Mutations on Asp(305), a residue located at the centre of the H-bond network, raised the K(m) value of the enzyme by 4.4-19-fold, but decreased the k(cat) value by 79-2842-fold, indicating that Asp(305) primarily plays a catalytic role. In addition, results from mutational studies on Ser(160) and His(319) suggest that these two residues might help to stabilize the conformations of Asp(248) and Asp(305) respectively. These data allow us to propose an essential proton transfer between Glu(201), Asp(305) and Asp(248) during the catalysis by animal QCs.

  14. Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II.

    PubMed

    Zhang, Hua; Chen, Hongsheng; Luo, Hunjin; An, Jing; Sun, Lin; Mei, Lingyun; He, Chufeng; Jiang, Lu; Jiang, Wen; Xia, Kun; Li, Jia-Da; Feng, Yong

    2012-03-01

    Waardenburg syndrome (WS) is an auditory-pigmentary disorder resulting from melanocyte defects, with varying combinations of sensorineural hearing loss and abnormal pigmentation of the hair, skin, and inner ear. WS is classified into four subtypes (WS1-WS4) based on additional symptoms. PAX3 and SOX10 are two transcription factors that can activate the expression of microphthalmia-associated transcription factor (MITF), a critical transcription factor for melanocyte development. Mutations of PAX3 are associated with WS1 and WS3, while mutations of SOX10 cause WS2 and WS4. Recently, we identified some novel WS-associated mutations in PAX3 and SOX10 in a cohort of Chinese WS patients. Here, we further identified an E248fsX30 SOX10 mutation in a family of WS2. We analyzed the subcellular distribution, expression and in vitro activity of two PAX3 mutations (p.H80D, p.H186fsX5) and four SOX10 mutations (p.E248fsX30, p.G37fsX58, p.G38fsX69 and p.R43X). Except H80D PAX3, which retained partial activity, the other mutants were unable to activate MITF promoter. The H80D PAX3 and E248fsX30 SOX10 were localized in the nucleus as wild type (WT) proteins, whereas the other mutant proteins were distributed in both cytoplasm and nucleus. Furthermore, E248fsX30 SOX10 protein retained the DNA-binding activity and showed dominant-negative effect on WT SOX10. However, E248fsX30 SOX10 protein seems to decay faster than the WT one, which may underlie the mild WS2 phenotype caused by this mutation.

  15. Fermi LAT detection of increase gamma-ray emission from OJ 248

    NASA Astrophysics Data System (ADS)

    Orienti, M.; D'Ammando, F.

    2012-09-01

    The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 127.7170254 deg, Dec: 24.1832836 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=0.94 (Hewitt & Burbidge 1993, ApJS, 87, 451).

  16. Basic Hydrodynamics of Richtmyer-Meshkov-type Growth and Oscillations in the ICF-Relevant Conditions

    DTIC Science & Technology

    2010-01-01

    Washington, DC 20375 3ARTEP Inc ., Ellicott City, Maryland 21042 4Department of Mechanical Engineering, Ben Gurion University, Beer Sheva, Israel...the 56-beam Nike KrF laser facility at the Naval Research Laboratory (3 kJ in 0.248 μm, see Obenschain et al. 1996). Basic hydrodynamics of Richtmyer...2000 Nike (NRL) 0.248 8-13 4 400 40 30, 45 1.85 Si monochrom. Ablative RMI, feedout, classical RMI, impulsive loading, re- shock

  17. Evaluation results for the positive deep-UV resist AZ DX 46

    NASA Astrophysics Data System (ADS)

    Spiess, Walter; Lynch, Thomas J.; Le Cornec, Charles; Escher, Gary C.; Kinoshita, Yoshiaki; Kochan, John; Kudo, Takanori; Masuda, Seiya; Mourier, Thierry; Nozaki, Yuko; Olson, Setha G.; Okazaki, Hiroshi; Padmanaban, Munirathna; Pawlowski, Georg; Przybilla, Klaus J.; Roeschert, Horst; Suehiro, Natusmi; Vinet, Francoise; Wengenroth, Horst

    1994-05-01

    This contribution emphasizes resist application site by communicating lithographic results for AZ DX 46, obtained using the GCA XLS 7800/31 stepper, NA equals 0.53, equipped with krypton fluoride excimer laser ((lambda) equals 248 nm), model 4500 D, as exposure source, delivered by Cymer Laser Technologies. As far as delay time experiments are concerned ASM-L PAS 5500/70 stepper, NA equals 0.42, was used in combination with Lambda Physik excimer laser, model 248 L.

  18. Legal and Social Protection for Soviet Servicemen: A Reality of Mere Declaration?

    DTIC Science & Technology

    1991-04-05

    in JPRS-UMA-90-023, 15 October 1990, p. 43. 41 Oleg Moskovskiy, Newscast, TASS International Service, 24 December 1990, in FBIS-SOV-90-248, 26...in CDSP, 7 November 1990, p. 30. 67 S. Kuznetsov , "For Whom the Paratroopers Are Looking," Selskaya zhizn, 12 January 1991, p. 6, in FBIS-SOV-91-012... Oleg . Newscast. TASS International Service, 24 December 1990, in FBIS-SOV--90-248, 26 December 1990, p. 60. . Newscast. TASS, 29 January 1991, in

  19. Guidelines for Designing User Interface Software

    DTIC Science & Technology

    1986-08-01

    2.4.4 Bar Graphs 150 2.4.5 Pie Charts 154 2.4.6 Pictures and Diagrams 156 2.4.7 Flowcharts 159 2.4.8 Maps and Situation Displays 163 2.5 Format...Pictures and diagrams 156 2.4.7 Flowcharts 159 2.4.8 Maps and situation displays 163 2.5 Format refers to the organization of different types of...computer aids for calculating area, volume, center of gravity, modes of vibration, stresses, heat transfer, etc. 158 DATA DISPLAY Flowcharts

  20. The Behaviour of the Military Battery Type BB248/U Used to Start the Engine of the A.P.C.

    DTIC Science & Technology

    1979-12-01

    UNCLASS IFIED I I ABSTRACT ~ ‘The performance of the lead—acid battery used to start the diesel engine ~~~~he Armoured Personnel Carrier...vehicle engines . One factor limiting the performance of this battery system is the very low Canadian winter temperatures, especially in Northern...information on the conditions of discharge inside the vehicle. For example, the military battery type BB248/U used to start the engine of the Armoured

  1. Quantum yield for carbon monoxide production in the 248 nm photodissociation of carbonyl sulfide (OCS)

    NASA Technical Reports Server (NTRS)

    Zhao, Z.; Stickel, R. E.; Wine, P. H.

    1995-01-01

    Tunable diode laser absorption spectroscopy has been coupled with excimer laser flash photolysis to measure the quantum yield for CO production from 248 nm photodissociation of carbonyl sulfide (OCS) relative to the well-known quantum yield for CO production from 248 nm photolysis of phosgene (Cl2CO2). The temporal resolution of the experiments was sufficient to distinguish CO formed directly by photodissociation from that formed by subsequent S((sup 3)P(sub J)) reaction with OCS. Under the experimental conditions employed, CO formation via the fast S((sup 1)D(sub 2)) + OCS reaction was minimal. Measurements at 297K and total pressures from 4 to 100 Torr N2 + N2O show the CO yield to be greater than 0.95 and most likely unity. This result suggests that the contribution of OCS as a precursor to the lower stratospheric sulfate aerosol layer is somewhat larger than previously thought.

  2. Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

    PubMed

    Zhang, De-Liang; Wu, Jian; Shah, Binal N; Greutélaers, Katja C; Ghosh, Manik C; Ollivierre, Hayden; Su, Xin-Zhuan; Thuma, Philip E; Bedu-Addo, George; Mockenhaupt, Frank P; Gordeuk, Victor R; Rouault, Tracey A

    2018-03-30

    Malaria parasites invade red blood cells (RBCs), consume copious amounts of hemoglobin, and severely disrupt iron regulation in humans. Anemia often accompanies malaria disease; however, iron supplementation therapy inexplicably exacerbates malarial infections. Here we found that the iron exporter ferroportin (FPN) was highly abundant in RBCs, and iron supplementation suppressed its activity. Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected mice. In humans, a prevalent FPN mutation, Q248H (glutamine to histidine at position 248), prevented hepcidin-induced degradation of FPN and protected against severe malaria disease. FPN Q248H appears to have been positively selected in African populations in response to the impact of malaria disease. Thus, FPN protects RBCs against oxidative stress and malaria infection. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  3. Superheavy element chemistry at GARIS

    NASA Astrophysics Data System (ADS)

    Haba, Hiromitsu

    2016-12-01

    A gas-jet transport system has been installed to the RIKEN GAs-filled Recoil Ion Separator, GARIS to start up SuperHeavy Element (SHE) chemistry. This system is a promising approach for exploring new frontiers in SHE chemistry: background radioactivities from unwanted by-products are suppressed, a high gas-jet transport yield is achieved, and new chemical reactions can be investigated. Useful radioisotopes of 261Rfa,b, 262Db, and 265Sga,b for chemical studies were produced in the reactions of 248Cm(18O,5n)261Rfa,b, 248Cm(19F,5n)262Db, and 248Cm(22Ne,5n)265Sga,b, respectively. They were successfully extracted to a chemistry laboratory by the gas-jet method. Production and decay properties of 261Rfa,b, 262Db, and 265Sga,b were investigated in detail with the rotating wheel apparatus for α- and spontaneous fission spectrometry. Present status and perspectives of the SHE chemistry at GARIS are also briefly presented.

  4. Rate of occurrence, gross appearance, and age relation of hyperostosis frontalis interna in females: a prospective autopsy study.

    PubMed

    Nikolić, Slobodan; Djonić, Danijela; Zivković, Vladimir; Babić, Dragan; Juković, Fehim; Djurić, Marija

    2010-09-01

    The aim of our study was to determine rate of occurrence and appearance of hyperostosis frontalis interna (HFI) in females and correlation of this phenomenon with ageing. The sample included 248 deceased females: 45 of them with different types of HFI, and 203 without HFI, average age 68.3 +/- 15.4 years (range, 19-93), and 58.2 +/- 20.2 years (range, 10-101), respectively. According to our results, the rate of HFI was 18.14%. The older the woman was, the higher the possibility of HFI occurring (Pearson correlation 0.211, N=248, P=0.001), but the type of HFI did not correlate with age (Pearson correlation 0.229, N=45, P=0.131). Frontal and temporal bone were significantly thicker in women with than in women without HFI (t= -10.490, DF=246, P=0.000, and t= -5.658, DF=246, P=0.000, respectively). These bones became thicker with ageing (Pearson correlation 0.178, N=248, P=0.005, and 0.303, N=248, P=0.000, respectively). The best predictors of HFI occurrence were respectively, frontal bone thickness, temporal bone thickness, and age(Wald. coeff.=35.487, P=0.000; Wald. coeff.=3.288, P=0.070, and Wald.coeff. =2.727, P =0.099). Diagnosis of HFI depends not only on frontal bone thickness, but also on waviness of internal plate of the frontal bone, as well as-the involvement of the inner bone surface.

  5. Non-chemically amplified 248-nm resist materials

    NASA Astrophysics Data System (ADS)

    Willson, C. Grant; Yueh, Wang; Leeson, Michael J.; Steinhausler, Thomas; McAdams, Christopher L.; Dammel, Ralph R.; Sounik, James R.; Aslam, M.; Vicari, Richard; Sheehan, Michael

    1997-07-01

    Remarkable progress has been made in the formulation of chemically amplified resists for deep-UV (DUV or 248 nm) lithography. These materials are now in general use in full scale manufacturing. One of the deterrents to rapid and universal adoption of DUV lithography has been the combination of high cost of ownership and a narrow process latitude when compared to conventional i-line process alternatives. A significant part of the high cost of the DUV process is associated with installing and maintaining special air handling equipment that is required to remove basic contaminants from the ambient. Manufacture process latitude demands this special air handling. The chemically amplified resists were developed originally to support mercury lamp powered exposure systems. The sensitivity realized by chemical amplification is required to enable useful productivity with such systems that generate very little DUV flux at the wafer plane. With the advent of high powered excimer laser based illumination systems for 248 nm steppers and step-and-scan systems, it is appropriate to re-examine the applicability of non-chemically amplified DUV resist systems. These systems are less sensitive but have the potential to offer both lower cost of ownership and improved process latitude. A series of photoactive compounds (PACs) have been synthesized and auditioned for use in the formulation of a non-chemically amplified 248 nm resist. The most promising of these materials are analogs of 3-oxo-3-diazocoumarin. This chromophore displays photochemistry that is analogous to that of the diazonaphthoquinones (DNQ) that are the basis of i-line resist formulations, but it bleaches at 248 nm. Several structural analogs of the chromophore have been synthesized and a variety of ballast groups have been studied with the goal of enhancing the dissolution inhibition properties of the molecule. The diazocoumarin PACs have been formulated with customized phenolic resins that were designed to provide the combination of optical transparency, dry etch resistance and the dissolution characteristics that are required for manufacturing applications. The resins are copolymers of poly(4-hydroxystyrene) and blends of these polymers with novolac.

  6. Photochemical and Spectroscopic Effects Resulting from Excimer Laser Excitation.

    NASA Astrophysics Data System (ADS)

    Wang, Xuan Xiao

    I. Photochemical production of ozone from pure oxygen using excimer lasers. Production of ozone was observed from experiments when oxygen was under a broadband pulsed KrF laser radiation. The production process was found to be autocatalytic. Mechanisms for the ozone formation were proposed. Experimental results over a range of oxygen pressure and laser pulse energy (irradiance) provided evidences in favor of the proposed mechanisms. Experiments were also numerically modeled. Good agreement between the experimental and the numerical results were observed, which provided further evidence to support the proposed mechanisms. Cross sections for some photochemical processes in the mechanisms were estimated. Production of ozone from pure oxygen under a ArF excimer laser radiation (193 nm) was also studied and numerically modeled. Effects of ambient water vapor on ozone production were investigated. Experimental results showed a fast ozone destruction when water vapor was present in the cell. However, numerical results obtained from the well-known OH and HO _2 chain ozone destruction mechanism predicted a slower ozone destruction. Possible reasons for the discrepancy are discussed. II. Resonance-enhanced multiphoton ionization of N_2 at 193 and 248 nm detected by N_sp{2}{+} fluorescence. Using a broadband excimer laser operating at 193 and 248 nm multiphoton ionization at high pressures in air and pure nitrogen has been detected by fluorescence from N_sp{2}{+} in the B-X firstnegative system. Measurements of the fluorescence intensity as a function of beam irradiance indicate resonance in N_2 at the energy of two 193 nm photons (2 + 1 REMPI) and three 248 nm photons (3 + 1 REMPI). Possible intermediate states are discussed. III. Excimer laser-induced fluorescence from some organic solvents. Fluorescence was observed from vapor phase benzene, toluene, p-xylene, benzyl chloride, methyl benzoate, acetic anhydride, ether, methanol, ethyl acetone, acetone, and 2-butanone using a broadband excimer laser operating at 248 nm and 308 nm as the source of excitation. Absolute fluorescence quantum yields for the substances under study were measured at 248 nm using toluene as the fluorescence standard. Fluorescence spectra from species produced from nonlinear photochemical processes were also studied.

  7. Crystal structure of the cytoplasmic phosphatase and tensin homolog (PTEN)-like region of Ciona intestinalis voltage-sensing phosphatase provides insight into substrate specificity and redox regulation of the phosphoinositide phosphatase activity.

    PubMed

    Matsuda, Makoto; Takeshita, Kohei; Kurokawa, Tatsuki; Sakata, Souhei; Suzuki, Mamoru; Yamashita, Eiki; Okamura, Yasushi; Nakagawa, Atsushi

    2011-07-01

    Ciona intestinalis voltage-sensing phosphatase (Ci-VSP) has a transmembrane voltage sensor domain and a cytoplasmic region sharing similarity to the phosphatase and tensin homolog (PTEN). It dephosphorylates phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon membrane depolarization. The cytoplasmic region is composed of a phosphatase domain and a putative membrane interaction domain, C2. Here we determined the crystal structures of the Ci-VSP cytoplasmic region in three distinct constructs, wild-type (248-576), wild-type (236-576), and G365A mutant (248-576). The crystal structure of WT-236 and G365A-248 had the disulfide bond between the catalytic residue Cys-363 and the adjacent residue Cys-310. On the other hand, the disulfide bond was not present in the crystal structure of WT-248. These suggest the possibility that Ci-VSP is regulated by reactive oxygen species as found in PTEN. These structures also revealed that the conformation of the TI loop in the active site of the Ci-VSP cytoplasmic region was distinct from the corresponding region of PTEN; Ci-VSP has glutamic acid (Glu-411) in the TI loop, orienting toward the center of active site pocket. Mutation of Glu-411 led to acquirement of increased activity toward phosphatidylinositol 3,5-bisphosphate, suggesting that this site is required for determining substrate specificity. Our results provide the basic information of the enzymatic mechanism of Ci-VSP.

  8. Photodissociation dynamics of the methyl perthiyl radical at 248 and 193 nm using fast-beam photofragment translational spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harrison, Aaron W.; Ryazanov, Mikhail; Sullivan, Erin N.

    2016-07-14

    The photodissociation dynamics of the methyl perthiyl radical (CH{sub 3}SS) have been investigated using fast-beam coincidence translational spectroscopy. Methyl perthiyl radicals were produced by photodetachment of the CH{sub 3}SS{sup −} anion followed by photodissociation at 248 nm (5.0 eV) and 193 nm (6.4 eV). Photofragment mass distributions and translational energy distributions were measured at each dissociation wavelength. Experimental results show S atom loss as the dominant (96%) dissociation channel at 248 nm with a near parallel, anisotropic angular distribution and translational energy peaking near the maximal energy available to ground state CH{sub 3}S and S fragments, indicating that the dissociationmore » occurs along a repulsive excited state. At 193 nm, S atom loss remains the major fragmentation channel, although S{sub 2} loss becomes more competitive and constitutes 32% of the fragmentation. The translational energy distributions for both channels are very broad at this wavelength, suggesting the formation of the S{sub 2} and S atom products in several excited electronic states.« less

  9. Choice of the laser wavelength for a herpetic keratitis treatment

    NASA Astrophysics Data System (ADS)

    Razhev, Alexander M.; Bagayev, Sergei N.; Chernikh, Valery V.; Kargapoltsev, Evgeny S.; Trunov, Alexander; Zhupikov, Andrey A.

    2002-06-01

    For the first time the effect of the UV laser radiation to human eye cornea with herpetic keratitis was experimentally investigated. In experiments the UV radiation of ArF (193 nm), KrCl (223 nm), KrF (248 nm) excimer lasers were used. Optimal laser radiation parameters for the treatment of the herpetic keratitis were determined. The immuno-biochemical investigations were carried out and the results of clinical trials are presented. The maximum ablation rate was obtained for the 248 nm radiation wavelength. The process of healing was successful but in some cases the haze on the surface of the cornea was observed. When used the 193 nm radiation wavelength the corneal surface was clear without any hazes but the epithelization process was slower than for 248 nm wavelength and in some cases the relapse was occurred. The best results for herpetic keratitis treatment have been achieved by utilizing the 223 nm radiation wavelength of the KrCl excimer laser. The use of the 223 nm radiation wavelength allows treating the herpetic keratitis with low traumatic process of ablation and provides high quality of corneal surface.

  10. The Association Between Suicide and OIF/OEF Deployment History. Addendum

    DTIC Science & Technology

    2015-03-01

    80.6) Female 36,467 (11.5) 186,922 (19.4) Race White 248,375 (78.2) 725,117 (75.2) Nonwhite 69,206 (21.8) 239,376 (24.8) Marital status* Married 163,053...51.3) 469,036 (48.6) Not married 154,528 (48.7) 495,457 (51.4) Year of discharge 2001 5202 (1.6) 119,373 (12.4) 2002 7777 (2.5) 123,728 (12.8) 2003...2007. Not Married category includes single, divorced, and separated individuals. y Last recorded through end of 2007. H.K. Kang et al. / Annals of

  11. Summer Faculty Systems Design Program. Integrating Wind Tunnels and Computers. Volume 2. Details of Summer Design Study USAF/OSR/ASEE

    DTIC Science & Technology

    1977-08-01

    level is given in the report by El- Ramly and Rainbird of Carleton University in Ontario Canada (Ref. 2.48). This report comments on an investigation of...RefT 3, Äp r i 1 1976. 2.48. El- Ramly , Z. M. and Rainbird, W. J. "Computer-Controlled System for the Investigation of the Flow Behind Wings...detailed studies of "model" equations (such as the Burgers ’ equation) which include all the essential aspects of the actual problem of interest have

  12. Comment on ``Dynamic Peierls-Nabarro equations for elastically isotropic crystals''

    NASA Astrophysics Data System (ADS)

    Markenscoff, Xanthippi

    2011-02-01

    The paper by Pellegrini [Phys. Rev. BPRBMDO0031-899X10.1103/PhysRevB.81.024101 81, 024101 (2010)] introduces additional “distributional terms” to the displacement of the static field of a dislocation and claims that they are needed so that Weertman's equation for the steady-state motion of the Peierls-Nabarro dislocation be recovered. He also claims that the [Eshelby, Phys. Rev.PHRVAO0031-899X10.1103/PhysRev.90.248 90, 248 (1953)] solution for a moving screw is wrong, a statement with which I disagree. The same [Eshelby, Phys. Rev.PHRVAO0031-899X10.1103/PhysRev.90.248 90, 248 (1953)] solution is also obtained and used by the eminent dislocation scientists Al’shitz and Indenbom in Al’shitz [Sov. Phys. JETP 33, 1240 (1971)] that the author ignores. A key reference in the formulation of the problem as a 3D inclusion with eigenstrain is Willis [J. Mech. Phys. SolidsJMPSA80022-509610.1016/0022-5096(65)90038-4 13, 377 (1965)] who showed that, in the transient fields, the static Eshelby equivalence of dislocations to inclusions (with eigenstrain) does not hold, but only at long times when they tend to the static ones. In this Comment the author provides the fundamental physics of the behavior of a moving Volterra dislocation in nonuniform motion by showing how the singular fields near the moving core are obtained from “first principles” (without solving for the full fields). The limit to the steady-state motion of a Peierls-Nabarro dislocation is also shown how to be obtained from first principles from the Volterra one by taking the appropriate limit, without the need of the additional distributional terms that Pellegrini introduces.

  13. Laser ablation of ceramic Al2O3 at 193 nm and 248 nm: The importance of single-photon ionization processes

    NASA Astrophysics Data System (ADS)

    Peláez, R. J.; Afonso, C. N.; Bator, M.; Lippert, T.

    2013-06-01

    The aim of this work is to demonstrate that single-photon photoionization processes make a significant difference in the expansion and temperature of the plasma produced by laser ablation of ceramic Al2O3 in vacuum as well as to show their consequences in the kinetic energy distribution of the species that eventually will impact on the film properties produced by pulsed laser deposition. This work compares results obtained by mass spectrometry and optical spectroscopy on the composition and features of the plasma produced by laser ablation at 193 nm and 248 nm, i.e., photon energies that are, respectively, above and below the ionization potential of Al, and for fluences between threshold for visible plasma and up to ≈2 times higher. The results show that the ionic composition and excitation of the plasma as well as the ion kinetic energies are much higher at 193 nm than at 248 nm and, in the latter case, the population of excited ions is even negligible. The comparison of Maxwell-Boltzmann temperature, electron temperatures, and densities of the plasmas produced with the two laser wavelengths suggests that the expansion of the plasma produced at 248 nm is dominated by a single population. Instead, the one produced at 193 nm is consistent with the existence of two populations of cold and hot species, the latter associated to Al+ ions that travel at the forefront and produced by single photon ionization as well as Al neutrals and double ionized ions produced by electron-ion impact. The results also show that the most energetic Al neutrals in the plasma produced at the two studied wavelengths are in the ground state.

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garabedian, G.

    This document details the decontamination and decommissioning (D&D) process of Rooms 248 and 250 of Building 62 at the Ernest Orlando Lawrence Berkeley National Laboratory (LBNL). The document describes the D&D efforts for the rooms, their contents, and adjacent areas containing ancillary equipment. The rooms and equipment, before being released, were required to meet the unrestricted release criteria and requirements set forth in DOE orders 5400.5 and 5480.11, LBNL`s internal release-criteria procedure (EH&S Procedure 708), and the LBNL Radiological Control Manual. The radioactive material and items not meeting the release criteria were either sent to the Hazardous Waste Handling Facilitymore » (HWHF) for disposal or transferred to other locations approved for radioactive material. The D&D was undertaken by the Radiation Protection Group of LBNL`s Environment, Health and Safety (EH&S) Division at the request of the Materials Sciences Division. Current and past use of radioactive material in both Rooms 248 and 250 necessitated the D&D in order to release both rooms for nonradioactive work. (1) Room 248 was designated a {open_quotes}controlled area.{close_quotes} There was contained radioactive material in some of the equipment. The previous occupants of Room 248 had worked with radioactive materials. (2) Room 250 was designated a {open_quotes}Radioactive Materials Management Area{close_quotes} (RMMA) because the current occupants used potentially dispersible radioisotopes. Both laboratories, during the occupancy of U.C. Berkeley Professor Leo Brewer and Ms. Karen Krushwitz, were kept in excellent condition. There was a detailed inventory of all radioactive materials and chemicals. All work and self surveys were documented. The labs were kept extremely orderly, clean, and in compliance. In October 1993 Ms. Krushwitz received an award in recognition of her efforts in Environmental Protection, Health, and Safety at LBNL.« less

  15. Direct Synthesis of Renewable Dodecanol and Dodecane with Methyl Isobutyl Ketone over Dual-Bed Catalyst Systems.

    PubMed

    Sheng, Xueru; Li, Ning; Li, Guangyi; Wang, Wentao; Wang, Aiqin; Cong, Yu; Wang, Xiaodong; Zhang, Tao

    2017-03-09

    For the first time, we demonstrated two integrated processes for the direct synthesis of dodecanol or 2,4,8-trimethylnonane (a jet fuel range C 12 -branched alkane) using methyl isobutyl ketone (MIBK) that can be derived from lignocellulose. The reactions were carried out in dual-bed continuous flow reactors. In the first bed, MIBK was selectively converted to a mixture of C 12 alcohol and ketone. Over the Pd-modified magnesium- aluminium hydrotalcite (Pd-MgAl-HT) catalyst, a high total carbon yield (73.0 %) of C 12 oxygenates can be achieved under mild conditions. In the second bed, the C 12 oxygenates generated in the first bed were hydrogenated to dodecanol over a Ru/C catalyst or hydrodeoxygenated to 2,4,8-trimethylnonane over a Cu/SiO 2 catalyst. The as-obtained dodecanol can be used as feedstock in the production of sodium dodecylsulfate (SDS) and sodium dodecyl benzene sulfonate (SDBS), which are widely used as surfactants or detergents. The asobtained 2,4,8-trimethylnonane can be blended into conventional jet fuel without hydroisomerization. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Spontaneous Partitioning of Californium from Curium: Curious Cases from the Crystallization of Curium Coordination Complexes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cary, Samantha K.; Silver, Mark A.; Liu, Guokui

    The reaction of 248CmCl3 with excess 2,6-pyridinedicarboxylic acid (DPA) under mild solvothermal conditions results in crystallization of the tris-chelate complex Cm(HDPA)3·H2O. Approximately half of the curium remains in solution at the end of this process, and evaporation of the mother liquor results in crystallization of the bis-chelate complex [Cm(HDPA)- (H2DPA)(H2O)2Cl]Cl·2H2O. 248Cm is the daughter of the α decay of 252Cf and is extracted in high purity from this parent. However, trace amounts of 249,250,251Cf are still present in all samples of 248Cm. During the crystallization of Cm(HDPA)3·H2O and [Cm(HDPA)(H2DPA)(H2O)2Cl]Cl·2H2O, californium(III) spontaneously separates itself from the curium complexes and is foundmore » doped within crystals of DPA in the form of Cf(HDPA)3. These results add to the growing body of evidence that the chemistry of californium is fundamentally different from that of earlier actinides.« less

  17. Antimalarial drug susceptibility and point mutations associated with drug resistance in 248 Plasmodium falciparum isolates imported from Comoros to Marseille, France in 2004 2006.

    PubMed

    Parola, Philippe; Pradines, Bruno; Simon, Fabrice; Carlotti, Marie-Paule; Minodier, Philippe; Ranjeva, Marie-Pierre; Badiaga, Sékéné; Bertaux, Lionel; Delmont, Jean; Morillon, Marc; Silai, Ramatou; Brouqui, Philippe; Parzy, Daniel

    2007-09-01

    A total of 248 Plasmodium falciparum isolates were sampled in travelers with malaria who came to Marseille, France from Comoros to investigate in vitro activities of antimalarial drugs and molecular markers of drug resistance. Of the 248 isolates, 126 were maintained in culture. Of these, 53% were resistant to chloroquine, and 3% had reduced susceptibility to quinine, mefloquine, and atovaquone; 1% had reduced susceptibility to halofantrine and dihydroartemisinin; 7% had reduced susceptibility to monodesethylamodiaquine; 37% had reduced susceptibility to cycloguanil; and none had reduced susceptibility to lumefantrine. Resistance-associated point mutations were screened in 207 isolates. No mutations in the cytochrome b gene were found. Of the 207 isolates, 119 (58%) had a mutation in the P. falciparum dihydrofolate reductase (Pfdhfr) gene at codon 108, 6 (5%) had mutations in both Pfdhfr codon 108 and the P. falciparum dihydropteroate synthase codon 437, and 115 (56%) had the chloroquine resistance-associated K76T mutation in the P. falciparum chloroquine resistance transporter gene. This study represents a unique opportunity to improve surveillance of P. falciparum drug resistance in Comoros with consequences for treatment and chemoprophylaxis guidelines.

  18. Rapid fabrication of rigid biodegradable scaffolds by excimer laser mask projection technique: a comparison between 248 and 308 nm

    NASA Astrophysics Data System (ADS)

    Beke, S.; Anjum, F.; Ceseracciu, L.; Romano, I.; Athanassiou, A.; Diaspro, A.; Brandi, F.

    2013-03-01

    High-resolution photocrosslinking of the biodegradable poly(propylene fumarate) (PPF) and diethyl fumarate (DEF), using pulsed laser light at 248 and 308 nm is presented. The curing depth can be modulated between a few hundreds of nm and a few μm when using 248 nm and ten to a hundred μm when using 308 nm. By adjusting the total fluence (pulse numbers×laser fluence) dose and the weight ratios of PPF, DEF, and the photoinitiator in the photocrosslinkable mixtures, the height of polymerized structures can be precisely tuned. The lateral resolution is evaluated by projecting a pattern of a grid with a specified line width and line spacing. Young’s modulus of the cured parts is measured and found to be several GPa for both wavelengths, high enough to support bone formation. Several 2D and 2.5D microstructures, as well as porous 3D scaffolds fabricated by a layer-by-layer method, are presented. The results demonstrate that excimer laser-based photocuring is suitable for the fabrication of stiff and biocompatible structures with defined patterns of micrometer resolution in all three spatial dimensions.

  19. Photodissociation of pernitric acid (HO2NO2) at 248 nm

    NASA Technical Reports Server (NTRS)

    Macleod, Helene; Smith, Gregory P.; Golden, David M.

    1989-01-01

    The photodissociation of pernitric acid (PNA) was studied at 248 nm. The quantum yield for production of OH radicals is 34 + or - 16 percent. The yield of OH from PNA was measured relative to that of H2O2. The translational and rotational energy content of the OH photofragment from PNA was characterized. A fluorescent emission was also observed and characterized. It is attributed to electronically excited NO2 produced in the PNA photodissociation. A maximum yield of 30 percent for NO2 production was determined. The intensity of this emission, and a mass spectrometric peak at m/e = 33, were found to be useful means of characterizing the purity of the PNA sample.

  20. A new laboratory source of ozone and its potential atmospheric implications

    NASA Astrophysics Data System (ADS)

    Slanger, T. G.; Jusinski, L. E.; Black, G.; Gadd, G. E.

    1988-08-01

    Although 248-nm radiation falls 0.12 eV short of the energy needed to dissociate O2, large densities of ozone (O3) can be produced from unfocused 248-nm KrF excimer laser irradiation of pure O2. As soon as any O3 is present, it strongly absorbs the 248-nanometer radiation and dissociates to vibrationally excited ground state O2 (among other products), with a quantum yield of 0.1 to 0.15. During the laser pulse, a portion of these molecules absorb a photon and dissociate, which results in the production of three oxygen atoms for one O3 molecule destroyed. Recombination then converts these atoms to O3, and thus O3 production in the system is autocatalytic. A deficiency exists in current models of O3 photochemistry in the upper stratosphere and mesosphere, in that more O3 is found than can be explained. A detailed analysis of the system as it applies to the upper atmosphere is not yet possible, but with reasonable assumptions about O2 vibrational distributions resulting from O3 photodissociation and about relaxation rates of vibrationally excited O2, a case can be made for the importance of including this mechanism in the models.

  1. Fusion-fission and quasifission of superheavy systems with Z =110 -116 formed in 48Ca-induced reactions

    NASA Astrophysics Data System (ADS)

    Kozulin, E. M.; Knyazheva, G. N.; Itkis, I. M.; Itkis, M. G.; Bogachev, A. A.; Chernysheva, E. V.; Krupa, L.; Hanappe, F.; Dorvaux, O.; Stuttgé, L.; Trzaska, W. H.; Schmitt, C.; Chubarian, G.

    2014-11-01

    Background: In heavy-ion-induced reactions the mechanism leading to the formation of the compound nucleus and the role of quasifission is still not clear. Purpose: Investigation of the quasifission process of superheavy composite systems with Z =110 -116 and comparison with properties of fusion-fission and quasifission of lighter composite systems. Method: Mass and energy distributions of fissionlike fragments formed in the reactions 48Ca+232Th, 238U , 244Pu , and 248Cm at energies near the Coulomb barrier have been measured using the double-arm time-of-flight spectrometer CORSET at the U-400 cyclotron of the FLNR JINR. Results: The most probable fragment masses as well as total kinetic energies and their dispersions in dependence on the interaction energies and ion-target combinations have been studied for asymmetric and symmetric fragments formed in the reactions. The capture cross sections were obtained for the reactions 48Ca+244Pu and 248Cm . The lower limits for fission barriers of 283 -286Cn , 289 -292Fl , and 293 -296Lv compound nuclei were estimated. Conclusions: Analysis of the properties of symmetric fragments has shown that a significant part of these fragments may be attributed to fusion-fission process for the reactions 48Ca +238U , 244Pu , and 248Cm .

  2. Optimization of 248nm bottom anti-reflective coatings with thin film and high etch rate on real device

    NASA Astrophysics Data System (ADS)

    Kim, MyoungSoo; Kim, HakJoon; Shim, KewChan; Jeon, JeHa; Gil, MyungGoon; Song, YongWook; Enomoto, Tomoyuki; Sakaguchi, Takahiro; Nakajima, Yasuyuki

    2005-05-01

    A frequent problem encountered by photoresists during the manufacturing of semiconductor device is that activating radiation is reflected back into the photoresist by the substrate. So, it is necessary that the light reflection is reduced from the substrate. One approach to reduce the light reflection is the use of bottom anti-reflective coating (BARC) applied to the substrate beneath the photoresist layer. The BARC technology has been utilized for a few years to minimize the reflectivity. As the chip size is reduced to sub 100nm, the photoresist thickness has to decrease with the aspect ratio being less than 3.0. Therefore, new Organic BARC is strongly required which has the minimum reflectivity with thinner BARC thickness and higher etch selectivity toward resists. Hynix Semiconductor Inc., Nissan Chemical Industries, Ltd., and Brewer Science, Inc. have developed the advanced Organic BARC for achieving the above purpose. As a result, the suitable high performance 248nm Organic BARCs, NCA series, were achieved. Using CF4 gas as etchant, the plasma etch rate of NCA series is about 1.4 times higher than that of conventional 248nm resists. NCA series can be minimizing the substrate reflectivity at below 45nm BARC thickness. NCA series show the excellent litho performance and coating property on real device.

  3. Comparison between DNA Detection in Trigeminal Nerve Ganglia and Serology to Detect Cattle Infected with Bovine Herpesviruses Types 1 and 5

    PubMed Central

    Furtado, Agustin; Torres, Fabrício Dias; Franco, Ana Cláudia; Maisonnave, Jacqueline; Roehe, Paulo Michel

    2016-01-01

    Bovine herpesviruses (BoHVs) types 1 (BoHV-1) and 5 (BoHV-5) are alphaherpesviruses of major importance to the bovine production chain. Such viruses are capable of establishing latent infections in neuronal tissues. Infected animals tend to develop a serological response to infection; however, such response—usually investigated by antibody assays in serum—may eventually not be detected in laboratory assays. Nevertheless, serological tests such as virus neutralization (VN) and various enzyme-linked immunosorbent assays (ELISAs) are widely employed to check individual or herd status of BoHV infections. The correlation between detection of antibodies and the presence of viral nucleic acids as indicatives of infection in infected cattle has not been deeply examined. In order to investigate such correlation, 248 bovine serum samples were tested by VN to BoHV-1 and BoHV-5, as well as in a widely employed (though not type-differential) gB ELISA (IDEXX IBR gB X2 Ab Test) in search for antibodies to BoHVs. Immediately after blood withdrawal, cattle were slaughtered and trigeminal ganglia (TG) excised for DNA extraction and viral nucleic acid detection (NAD) by nested PCR. Neutralizing antibodies to BoHV-1 and/or BoHV-5 were detected in 44.8% (111/248) of sera, whereas the gB ELISA detected antibodies in 51.2% (127/248) of the samples. However, genomes of either BoHV-1, BoHV-5, or both, were detected in TGs of 85.9% (213/248) of the animals. These findings reveal that the assays designed to detect antibodies to BoHV-1 and/or BoHV-5 employed here may fail to detect a significant number of latently infected animals (in this study, 35.7%). From such data, it is clear that antibody assays are poorly correlated with detection of viral genomes in BoHV-1 and BoHV-5-infected animals. PMID:27224314

  4. The dusty aftermath of SN Hunt 248: merger-burst remnant?

    NASA Astrophysics Data System (ADS)

    Mauerhan, Jon C.; Van Dyk, Schuyler D.; Johansson, Joel; Fox, Ori D.; Filippenko, Alexei V.; Graham, Melissa L.

    2018-01-01

    SN Hunt 248 was classified as a non-terminal eruption (a supernova 'impostor') from a directly identified and highly variable cool hypergiant star. The 2014 outburst achieved peak luminosity equivalent to that of the historic eruption of luminous blue variable (LBV) η Car, and exhibited a multipeaked optical light curve which rapidly faded after ∼100 d. We report ultraviolet (UV) through optical observations of SN Hunt 248 with the Hubble Space Telescope (HST) about 1 yr after the outburst, and mid-infrared observations with the Spitzer Space Telescope before the burst and in decline. The HST data reveal a source which is a factor of ∼10 dimmer in apparent brightness than the faintest available measurement of the precursor star. The UV-optical spectral energy distribution (SED) requires a strong Balmer continuum, consistent with a hot B4-B5 photosphere attenuated by grey circumstellar extinction. Substantial mid-infrared excess of the source is consistent with thermal emission from hot dust with a mass of ∼10-6-10-5 M⊙ and a geometric extent which is comparable to the expansion radius of the ejecta from the 2014 event. SED modelling indicates that the dust consists of relatively large grains ( > 0.3 μm), which could be related to the grey circumstellar extinction which we infer for the UV-optical counterpart. Revised analysis of the precursor photometry is also consistent with grey extinction by circumstellar dust, and suggests that the initial mass of the star could be twice as large as previously estimated (nearly ∼ 60 M⊙). Re-analysis of the earlier outburst data shows that the peak luminosity and outflow velocity of the eruption are consistent with a trend exhibited by stellar merger candidates, prompting speculation that SN Hunt 248 may also have stemmed from a massive stellar merger or common-envelope ejection.

  5. Insulin-like growth factor binding protein-2: contributions of the C-terminal domain to insulin-like growth factor-1 binding.

    PubMed

    Kibbey, Megan M; Jameson, Mark J; Eaton, Erin M; Rosenzweig, Steven A

    2006-03-01

    Signaling by the insulin-like growth factor (IGF)-1 receptor (IGF-1R) has been implicated in the promotion and aggressiveness of breast, prostate, colorectal, and lung cancers. The IGF binding proteins (IGFBPs) represent a class of natural IGF antagonists that bind to and sequester IGF-1/2 from the IGF-1R, making them attractive candidates as therapeutics for cancer prevention and control. Recombinant human IGFBP-2 significantly attenuated IGF-1-stimulated MCF-7 cell proliferation with coaddition of 20 or 100 nM IGFBP-2 (50 or 80% inhibition, respectively). We previously identified IGF-1 contact sites both upstream and downstream of the CWCV motif (residues 247-250) in human IGFBP-2 (J Biol Chem 276:2880-2889, 2001). To further test their contributions to IGFBP-2 function, the single tryptophan in human IGFBP-2, Trp-248, was selectively cleaved with 2-(2'nitrophenylsulfenyl)-3-methyl-3 bromoindolenine (BNPS-skatole) and the BNPS-skatole products IGFBP-2(1-248) and IGFBP-2(249-289) as well as IGFBP-2(1-190) were expressed as glutathione S-transferase-fusion proteins and purified. Based on competition binding analysis, deletion of residues 249 to 289 caused an approximately 20-fold decrease in IGF-1 binding affinity (IGFBP-2 EC50 = 0.35 nM and IGFBP-2(1-248) = 7 nM). Removal of the remainder of the C-terminal domain had no further effect on affinity (IGFBP-2(1-190) EC50 = 9.2 nM). In kinetic assays, IGFBP-2(1-248) and IGFBP-2(1-190) exhibited more rapid association and dissociation rates than full-length IGFBP-2. These results confirm that regions upstream and downstream of the CWCV motif participate in IGF-1 binding. They further support the development of full-length IGFBP-2 as a cancer therapeutic.

  6. Mental Health Medications

    MedlinePlus

    ... which was a systematic review of 248 clinical studies published between January 1980 and January 2011 examining the comparative effectiveness, benefits, and adverse effects of newer (“second- ...

  7. Thin film and high-etch-rate type 248-nm bottom antireflective coatings

    NASA Astrophysics Data System (ADS)

    Enomoto, Tomoyuki; Takei, Satoshi; Kishioka, Takahiro; Hatanaka, Tadashi; Sakamoto, Rikimaru; Nakajima, Yasuyuki

    2004-05-01

    A frequent problem encountered by photoresists during the manufacturing of semiconductor device is that activating radiation is reflected back into the photoresist by the substrate. So, it is necessary that the light reflection is reduced from the substrate. One approach to reduce the light reflection is the use of bottom anti-reflective coating (BARC) applied to the substrate beneath the photoresist layer. The BARC technology has been utilized for a few years to minimize the reflectivity. As the chip size is reduced to sub 0.13 micron, the photoresist thickness has to decrease with the aspect ratio being less than 3.0. Therefore, new Organic BARC is strongly required which has the minimum reflectivity with thinner BARC thickness and higher etch selectivity toward resists. Nissan Chemical Industries, Ltd. and Brewer Science, Inc. have developed the advanced Organic BARC for achieving the above purpose. As a result, the suitable high performance NCA3000 series 248nm Organic BARCs were developed. Using CF4 gas as etchant, the plasma etch rate of NCA3000 series is about 1.4-1.6 times higher than that of conventional 248nm resists and 1.1-1.2 times higher than that of the existing product. The NCA3000 series can minimize the substrate reflectivity at below 45nm BARC thickness, shows excellent litho performance and coating properties.

  8. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  9. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  10. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  11. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  12. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  13. 14 CFR 248.2 - Filing of audit reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... made by independent public accountants, such air carrier shall file with the Office of Airline... submitted by such independent public accountants, including all schedules, exhibits, and certificates...

  14. Motor competence and physical fitness in adolescents.

    PubMed

    Gísladóttir, Ordís; Haga, Monika; Sigmundsson, Hermundur

    2014-01-01

    In this study we examined the relationship between physical fitness and motor competence in adolescents aged 15 to 16 years. A sample of 94 adolescents participated in the study. To test motor competence, the Movement Assessment Battery for Children-2 was used. Physical fitness was assessed using the following test items: standing broad jump, 20-m dash, reduced Cooper test, and sit-and-reach test. The results revealed a significant but weak relationship (0.248) between motor competence and physical fitness for the whole sample. More specifically, the correlation between the 2 variables was significant for girls (0.353) but not for boys (0.248). The relatively weak relationship between motor competence and physical fitness suggests that motor competence might not be critical in adolescents to maintain their physical fitness.

  15. Photolysis of CH{sub 3}CHO at 248 nm: Evidence of triple fragmentation from primary quantum yield of CH{sub 3} and HCO radicals and H atoms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morajkar, Pranay; Schoemaecker, Coralie; Fittschen, Christa, E-mail: christa.fittschen@univ-lille1.fr

    2014-06-07

    Radical quantum yields have been measured following the 248 nm photolysis of acetaldehyde, CH{sub 3}CHO. HCO radical and H atom yields have been quantified by time resolved continuous wave Cavity Ring Down Spectroscopy in the near infrared following their conversion to HO{sub 2} radicals by reaction with O{sub 2}. The CH{sub 3} radical yield has been determined using the same technique following their conversion into CH{sub 3}O{sub 2}. Absolute yields have been deduced for HCO radicals and H atoms through fitting of time resolved HO{sub 2} profiles, obtained under various O{sub 2} concentrations, to a complex model, while the CH{submore » 3} yield has been determined relative to the CH{sub 3} yield from 248 nm photolysis of CH{sub 3}I. Time resolved HO{sub 2} profiles under very low O{sub 2} concentrations suggest that another unknown HO{sub 2} forming reaction path exists in this reaction system besides the conversion of HCO radicals and H atoms by reaction with O{sub 2}. HO{sub 2} profiles can be well reproduced under a large range of experimental conditions with the following quantum yields: CH{sub 3}CHO + hν{sub 248nm} → CH{sub 3}CHO{sup *}, CH{sub 3}CHO{sup *} → CH{sub 3} + HCO ϕ{sub 1a} = 0.125 ± 0.03, CH{sub 3}CHO{sup *} → CH{sub 3} + H + CO ϕ{sub 1e} = 0.205 ± 0.04, CH{sub 3}CHO{sup *}→{sup o{sub 2}}CH{sub 3}CO + HO{sub 2} ϕ{sub 1f} = 0.07 ± 0.01. The CH{sub 3}O{sub 2} quantum yield has been determined in separate experiments as ϕ{sub CH{sub 3}} = 0.33 ± 0.03 and is in excellent agreement with the CH{sub 3} yields derived from the HO{sub 2} measurements considering that the triple fragmentation (R1e) is an important reaction path in the 248 nm photolysis of CH{sub 3}CHO. From arithmetic considerations taking into account the HO{sub 2} and CH{sub 3} measurements we deduce a remaining quantum yield for the molecular pathway: CH{sub 3}CHO{sup *} → CH{sub 4} + CO ϕ{sub 1b} = 0.6. All experiments can be consistently explained with absence of the formerly considered pathway: CH{sub 3}CHO{sup *} → CH{sub 3}CO + H ϕ{sub 1c} = 0.« less

  16. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... leading to a consent agreement. (d) This paragraph applies to broadcast proceedings only. (1) At the...) In hearings involving applications for new, improved and changed facilities and in comparative...

  17. 24 CFR 248.201 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... cash or assets for subsequent withdrawal, and excluding repayment of advances made for reasonable and... long-range planning by the board of directors to ensure the physical, financial and social viability of...

  18. Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).

    PubMed

    Karlshøj, Stefanie; Amarandi, Roxana Maria; Larsen, Olav; Daugvilaite, Viktorija; Steen, Anne; Brvar, Matjaž; Pui, Aurel; Frimurer, Thomas Michael; Ulven, Trond; Rosenkilde, Mette Marie

    2016-12-23

    The small molecule metal ion chelators bipyridine and terpyridine complexed with Zn 2+ (ZnBip and ZnTerp) act as CCR5 agonists and strong positive allosteric modulators of CCL3 binding to CCR5, weak modulators of CCL4 binding, and competitors for CCL5 binding. Here we describe their binding site using computational modeling, binding, and functional studies on WT and mutated CCR5. The metal ion Zn 2+ is anchored to the chemokine receptor-conserved Glu-283 VII:06/7.39 Both chelators interact with aromatic residues in the transmembrane receptor domain. The additional pyridine ring of ZnTerp binds deeply in the major binding pocket and, in contrast to ZnBip, interacts directly with the Trp-248 VI:13/6.48 microswitch, contributing to its 8-fold higher potency. The impact of Trp-248 was further confirmed by ZnClTerp, a chloro-substituted version of ZnTerp that showed no inherent agonism but maintained positive allosteric modulation of CCL3 binding. Despite a similar overall binding mode of all three metal ion chelator complexes, the pyridine ring of ZnClTerp blocks the conformational switch of Trp-248 required for receptor activation, thereby explaining its lack of activity. Importantly, ZnClTerp becomes agonist to the same extent as ZnTerp upon Ala mutation of Ile-116 III:16/3.40 , a residue that constrains the Trp-248 microswitch in its inactive conformation. Binding studies with 125 I-CCL3 revealed an allosteric interface between the chemokine and the small molecule binding site, including residues Tyr-37 I:07/1.39 , Trp-86 II:20/2.60 , and Phe-109 III:09/3.33 The small molecules and CCL3 approach this interface from opposite directions, with some residues being mutually exploited. This study provides new insight into the molecular mechanism of CCR5 activation and paves the way for future allosteric drugs for chemokine receptors. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Aromatic–aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process

    PubMed Central

    Garneau, Line; Klein, Hélène; Lavoie, Marie-France; Brochiero, Emmanuelle; Parent, Lucie

    2014-01-01

    The Ca2+-activated potassium channel KCa3.1 is emerging as a therapeutic target for a large variety of health disorders. One distinguishing feature of KCa3.1 is that the channel open probability at saturating Ca2+ concentrations (Pomax) is low, typically 0.1–0.2 for KCa3.1 wild type. This observation argues for the binding of Ca2+ to the calmodulin (CaM)–KCa3.1 complex, promoting the formation of a preopen closed-state configuration leading to channel opening. We have previously shown that the KCa3.1 active gate is most likely located at the level of the selectivity filter. As Ca2+-dependent gating of KCa3.1 originates from the binding of Ca2+ to CaM in the C terminus, the hypothesis of a gate located at the level of the selectivity filter requires that the conformational change initiated in the C terminus be transmitted to the S5 and S6 transmembrane helices, with a resulting effect on the channel pore helix directly connected to the selectivity filter. A study was thus undertaken to determine to what extent the interactions between the channel pore helix with the S5 and S6 transmembrane segments contribute to KCa3.1 gating. Molecular dynamics simulations first revealed that the largest contact area between the pore helix and the S5 plus S6 transmembrane helices involves residue F248 at the C-terminal end of the pore helix. Unitary current recordings next confirmed that modulating aromatic–aromatic interactions between F248 and W216 of the S5 transmembrane helical segment and/or perturbing the interactions between F248 and residues in S6 surrounding the glycine hinge G274 cause important changes in Pomax. This work thus provides the first evidence for a key contribution of the pore helix in setting Pomax by stabilizing the channel closed configuration through aromatic–aromatic interactions involving F248 of the pore helix. We propose that the interface pore helix/S5 constitutes a promising site for designing KCa3.1 potentiators. PMID:24470490

  20. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... original stock certificates, and the like; necessary accounting services; expenses of temporary directors... securities, such as commissions, professional fees, and printing costs. This is so even where the particular...

  1. 7 CFR 248.17 - Management evaluations and reviews.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... deficiencies and prevent their future recurrence. (iii) If the corrective action plan is acceptable, FNS will... plan, and whether the deficiency is resolved or further corrective action is needed. Compliance buys...

  2. 75 FR 8341 - Product Cancellation Order for Certain Pesticide Registrations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... New 008660-00077 Patterson's Greenup Organic Bug Dust 008660-00084 Vertagreen Indoor Plant Spray... 72197 Roselle, Il 60172 008378 Knox Fertilizer Company P.O. Box 248 Knox, IN 46534 008660 United...

  3. 31 CFR 248.9 - Amendments and waivers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE ISSUE OF SUBSTITUTES OF LOST, STOLEN, DESTROYED... Amendments and waivers. The Treasury Department may waive, withdraw or amend at any time or from time to time...

  4. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... stock certificates, and the like; necessary accounting services; expenses of temporary directors and of... commissions, professional fees, and printing costs. This is so even where the particular issue of stock to...

  5. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  6. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  7. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  8. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  9. Ternary Amides Containing Transition Metals for Hydrogen Storage: A Case Study with Alkali Metal Amidozincates.

    PubMed

    Cao, Hujun; Richter, Theresia M M; Pistidda, Claudio; Chaudhary, Anna-Lisa; Santoru, Antonio; Gizer, Gökhan; Niewa, Rainer; Chen, Ping; Klassen, Thomas; Dornheim, Martin

    2015-11-01

    The alkali metal amidozincates Li4 [Zn(NH2)4](NH2)2 and K2[Zn(NH2)4] were, to the best of our knowledge, studied for the first time as hydrogen storage media. Compared with the LiNH2-2 LiH system, both Li4 [Zn(NH2)4](NH2)2-12 LiH and K2[Zn(NH2)4]-8 LiH systems showed improved rehydrogenation performance, especially K2[Zn(NH2)4]-8 LiH, which can be fully hydrogenated within 30 s at approximately 230 °C. The absorption properties are stable upon cycling. This work shows that ternary amides containing transition metals have great potential as hydrogen storage materials. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.

    PubMed

    Zagórska, Agnieszka; Kołaczkowski, Marcin; Bucki, Adam; Siwek, Agata; Kazek, Grzegorz; Satała, Grzegorz; Bojarski, Andrzej J; Partyka, Anna; Wesołowska, Anna; Pawłowski, Maciej

    2015-06-05

    A novel series of arylpiperazinylalkyl purine-2,4-diones (4-27) and purine-2,4,8-triones (31-38) was synthesized and tested to evaluated their affinity for the serotoninergic (5-HT1A, 5-HT6, 5-HT7) and dopaminergic (D2) receptors. Compounds with purine-2,4-dione nucleus generally had affinity values higher than the corresponding purine-2,4,8-trione compounds. A spectrum of receptor activities was observed for compounds with a substituent at the 7-position of the imidazo[2,1-f]purine-2,4-dione system and some potent 5-HT1A (18, 25), 5-HT7 (14) and mixed 5-HT1A/5-HT7 (8, 9) receptor ligands with additional affinity for dopamine D2 receptors (15) has been identified. Moreover, docking studies proved that a substituent at the 7-position of 1,3-dimethyl-(1H,8H)-imidazo[2,1-f]purine-2,4-dione could be essential for receptor affinity and selectivity, especially towards 5-HT1A and 5-HT7. The results of the preliminary pharmacological in vivo studies of selected derivatives of 1,3-dimethyl-(1H,8H)-imidazo[2,1-f]purine-2,4-dione, including 9 as a potential anxiolytic, 8 and 15 as potential antidepressants, and 18 and 25 as potential antidepressant and anxiolytic agents. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  11. Oxygen-limited cellobiose fermentation and the characterization of the cellobiase of an industrial Dekkera/Brettanomyces bruxellensis strain.

    PubMed

    Reis, Alexandre Libanio Silva; de Fátima Rodrigues de Souza, Raquel; Baptista Torres, Rochane Regina Neves; Leite, Fernanda Cristina Bezerra; Paiva, Patrícia Maria Guedes; Vidal, Esteban Espinosa; de Morais, Marcos Antonio

    2014-01-01

    The discovery of a novel yeast with a natural capacity to produce ethanol from lignocellulosic substrates (second-generation ethanol) is of great significance for bioethanol technology. While there are some yeast strains capable of assimilating cellobiose in aerobic laboratory conditions, the predominant sugar in the treatment of lignocellulosic material, little is known about this ability in real industrial conditions. Fermentations designed to simulate industrial conditions were conducted in synthetic medium with glucose, sucrose, cellobiose and hydrolyzed pre-treated cane bagasse as a different carbon source, with the aim of further characterizing the fermentation capacity of a promising Dekkera bruxellensis yeast strain, isolated from the bioethanol process in Brazil. As a result, it was found (for the first time in oxygen-limiting conditions) that the strain Dekkera bruxellensis GDB 248 could produce ethanol from cellobiose. Moreover, it was corroborated that the cellobiase activity characterizes the enzyme candidate in semi-purified extracts (β-glucosidase). In addition, it was demonstrated that GDB 248 strain had the capacity to produce a higher acetic acid concentration than ethanol and glycerol, which confirms the absence of the Custer effect with this strain in oxygen-limiting conditions. Moreover, it is also being suggested that D. bruxellensis could benefit Saccharomyces cerevisiae and outcompete it in the industrial environment. In this way, it was confirmed that D. bruxellensis GDB 248 has the potential to produce ethanol from cellobiose, and is a promising strain for the fermentation of lignocellulosic substrates.

  12. Joint Ventures for Bird Habitat Conservation Act of 2009

    THOMAS, 111th Congress

    Rep. Kratovil, Frank, Jr. [D-MD-1

    2009-04-30

    Senate - 12/21/2009 Placed on Senate Legislative Calendar under General Orders. Calendar No. 248. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  13. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  14. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  15. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  16. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  17. 43 CFR 2.48 - Standards for maintenance of records subject to the Act.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... by the First Amendment. No record may be maintained describing how any individual exercises rights guaranteed by the First Amendment to the Constitution unless the maintenance of the record is (1) expressly...

  18. 43 CFR 2.48 - Standards for maintenance of records subject to the Act.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... by the First Amendment. No record may be maintained describing how any individual exercises rights guaranteed by the First Amendment to the Constitution unless the maintenance of the record is (1) expressly...

  19. 43 CFR 2.48 - Standards for maintenance of records subject to the Act.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... by the First Amendment. No record may be maintained describing how any individual exercises rights guaranteed by the First Amendment to the Constitution unless the maintenance of the record is (1) expressly...

  20. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  1. A resolution expressing the sense of the Senate regarding Tunisia's peaceful Jasmine Revolution.

    THOMAS, 112th Congress

    Sen. Lieberman, Joseph I. [ID-CT

    2011-11-08

    Senate - 12/01/2011 Placed on Senate Legislative Calendar under General Orders. Calendar No. 248. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  3. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  4. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  5. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  6. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... marketing communications that are directed at the general public. For example, television, general... particular consumers would not constitute marketing solicitations, even if those communications are intended... communications. (3) Examples of marketing solicitations. A marketing solicitation would include, for example, a...

  7. 30 CFR 756.16 - Approval of the Hopi Tribe's abandoned mine land reclamation plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 86039, Telephone: (520) 734-2441. (b) Office of Surface Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [61...

  8. 30 CFR 756.16 - Approval of the Hopi Tribe's abandoned mine land reclamation plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 86039, Telephone: (520) 734-2441. (b) Office of Surface Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [61...

  9. 30 CFR 756.16 - Approval of the Hopi Tribe's abandoned mine land reclamation plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 86039, Telephone: (520) 734-2441. (b) Office of Surface Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [61...

  10. 30 CFR 756.16 - Approval of the Hopi Tribe's abandoned mine land reclamation plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 86039, Telephone: (520) 734-2441. (b) Office of Surface Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [61...

  11. 30 CFR 756.16 - Approval of the Hopi Tribe's abandoned mine land reclamation plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 86039, Telephone: (520) 734-2441. (b) Office of Surface Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [61...

  12. An integrated open-cavity system for magnetic bead manipulation.

    PubMed

    Abu-Nimeh, F T; Salem, F M

    2013-02-01

    Superparamagnetic beads are increasingly used in biomedical assays to manipulate, transport, and maneuver biomaterials. We present a low-cost integrated system designed in bulk CMOS to manipulate and separate biomedical magnetic beads. The system consists of 8 × 8 coil-arrays suitable for single bead manipulation, or collaborative multi-bead manipulation, using pseudo-parallel executions. We demonstrate the flexibility of the design in terms of different coil sizes, DC current levels, and layout techniques. In one array module example, the size of a single coil is 30 μm × 30 μm and the full array occupies an area of 248 μm × 248 μm in 0.5 μm CMOS technology. The programmable DC current source supports 8 discrete levels up to 1.5 mA. The total power consumption of the entire module is 9 mW when running at full power.

  13. Bioactive chemical constituents from the brown alga Homoeostrichus formosana.

    PubMed

    Fang, Hui-Yu; Chokkalingam, Uvarani; Chiou, Shu-Fen; Hwang, Tsong-Long; Chen, Shu-Li; Wang, Wei-Lung; Sheu, Jyh-Horng

    2014-12-30

    A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1-6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.

  14. Fusion-fission and quasifission in the reactions with heavy ions leading to the formation of Hs

    NASA Astrophysics Data System (ADS)

    Itkis, I. M.; Itkis, M. G.; Knyazheva, G. N.; Kozulin, E. M.

    2012-10-01

    Mass and energy distributions of binary reaction products obtained in the reactions 22Ne+249Cf,26Mg+248Cm,36S+238U and 58Fe+208Pb leading to Hs isotopes have been measured. At energies below the Coulomb barrier the bimodal fission of Hs*, formed in the reaction 26Mg+248Cm, is observed. In the reaction 36S+238U the considerable part of the symmetric fragments arises from the quasifission process. At energies above the Coulomb barrier the symmetric fragments originate mainly from fusion-fission process for both reactions with Mg and S ions. In the case of the 58Fe+208Pb reaction the quasifission process dominates at all measured energies. The pre- and post-scission neutron multiplicities as a function of the fragment mass have been obtained for the reactions studied.

  15. A Slot Allocation Model for High-Density Airports.

    DTIC Science & Technology

    1980-08-01

    Syracuse 51.85 ISO Kinston, N.C. 57.41 TPA Tampa 99.07 ISP Islip MacArthur 47.22 TYS Knoxville 67.59 JAX Jacksonville 8’i.26 C-3 TABLE 2 THIRD QUARTER... ISO 245 PI 2. 97. 116. 0.836 3 3 2 2 2 ISO DCA 245 PI 1. 71. 100. 0.710 2 1 1 1 1 uCA GSO 248 EA 2. 191. 229. 0.834 3 3 2 2 2 GS! DCA 248 3. 229. 307...0 1 1 0 0 0 1 1 t 0 1 1 1 0 1 i0 0 0 0 0 1 1 0 0 0 0 0 0 0 2 0 0 4 11 11 13 11 10 11 12 11 7 10 7 9 9 i 8 9 ISO IThP5 1 0 0 0 1 1 0 0 0 0 0 0 0 0 1 2

  16. Molecular growth from a Mo176 to a Mo248 cluster

    NASA Astrophysics Data System (ADS)

    Müller, A.; Shah, Syed Q. N.; Bögge, H.; Schmidtmann, M.

    1999-01-01

    In polyoxometalate chemistry a large variety of compounds, clusters and solid-state structures can be formed by the linking together of well-defined metal-oxygen building blocks, . These species exhibit unusual topological and electronic properties, andfind applications ranging from medicine to industrial processes. The recently reported ring-shaped mixed-valence polyoxomolybdates of the type {Mo154} (refs 5, 6) and {Mo176} (refs 7, 8) represent a new class of giant clusters with nanometre-sized cavities and interesting properties for host-guest chemistry. Here we describe the formation of related clusters of the type {Mo248} formed by addition of further units to the inner surface of the {Mo176 } `wheel'. The additional units arrange themselves into two {Mo36} `hub-caps' on the initial wheel-clusters that are not stable in isolation. These findings reveal a new pathway to the development of complex coordination clusters.

  17. Absolute 1* quantum yields for the ICN A state by diode laser gain versus absorption spectroscopy

    NASA Technical Reports Server (NTRS)

    Hess, Wayne P.; Leone, Stephen R.

    1987-01-01

    Absolute I* quantum yields were measured as a function of wavelength for room temperature photodissociation of the ICN A state continuum. The temperature yields are obtained by the technique of time-resolved diode laser gain-versus-absorption spectroscopy. Quantum yields are evaluated at seven wavelengths from 248 to 284 nm. The yield at 266 nm is 66.0 +/- 2% and it falls off to 53.4 +/- 2% and 44.0 +/- 4% at 284 and 248 respectively. The latter values are significantly higher than those obtained by previous workers using infrared fluorescence. Estimates of I* quantum yields obtained from analysis of CN photofragment rotational distributions, as discussed by other workers, are in good agreement with the I* yields. The results are considered in conjunction with recent theoretical and experimental work on the CN rotational distributions and with previous I* yield results.

  18. Results of borehole geophysical logging and aquifer-isolation tests conducted in the John Wagner and Sons, Inc. former production well, Ivyland, Pennsylvania

    USGS Publications Warehouse

    Sloto, Ronald A.

    1997-01-01

    A suite of borehole geophysical logs and heat-pulse-flowmeter measurements run in the former production well at the John Wagner and Sons, Inc. plant indicate two zones of borehole flow. In the upper part of the well, water enters the borehole through a fracture at 90 ft (feet) below floor level, moves upward, and exits the borehole through a fracture at 72 ft below floor level. Water also enters the borehole through fractures at 205-213, 235, and 357 ft below floor level; moves downward; and exits the borehole through fractures at 450-459, 468-470, and 483-490 ft below floor level. Five zones were selected for aquifer-isolation (packer) tests on the basis of borehole geophysical logs. The zones were isolated using a straddle-packer assembly. The lowermost three zones (below 248, 223 to 248, and 198 to 223 ft below floor level) were hydraulically isolated from zones above and below. Specific capacities were 0.12, 0.034, and 0.15 gallons per minute per foot, respectively. The hydrograph from zone 2 (223 to 248 ft below floor level) showed interference from a nearby pumping well. For the upper two zones (81 to 106 and 57 to 81 ft below floor level), similar drawdowns in the isolated zone and the zones above and below the isolated zone indicate that these fractures are hydraulically connected outside the borehole in the unconfined part of the Stockton Formation. The specific capacity of zones 4 and 5 are similar—0.82 and 0.61, respectively.

  19. Neonatal outcome of very preterm twins: policy of planned vaginal or cesarean delivery.

    PubMed

    Sentilhes, Loïc; Oppenheimer, Anne; Bouhours, Anne-Charlotte; Normand, Estelle; Haddad, Bassam; Descamps, Philippe; Marpeau, Loïc; Goffinet, François; Kayem, Gilles

    2015-07-01

    The objective of the study was to compare neonatal mortality and morbidity in very preterm twins with the first twin in cephalic presentation in hospitals with a policy of planned vaginal delivery (PVD) and those with a policy of planned cesarean delivery (PCD). Women with preterm cephalic first twins delivered after preterm labor and/or premature preterm rupture of membranes from 26(0/7) to 31(6/7) weeks of gestation were identified from the databases of 6 perinatal centers and classified as PVD or PCD according to the center's management policy from 1999 to 2010. Severe neonatal morbidity was defined as any of the following: intraventricular hemorrhage grades 3-4, periventricular leukomalacia, necrotizing enterocolitis, bronchopulmonary dysplasia, and hospital death. The independent effect of the planned mode of delivery, defined by the center's management policy, was tested and quantified with a 2-level multivariable logistic regression. The PVD group included 248 women, and the PCD group 63. Maternal characteristics did not differ between the 2 groups. The rate of vaginal delivery was 85.9% (213 of 248) vs 20.6% (13 of 63) (P < .001), and the rate of cesarean delivery for the second twin was 1.6% (4 of 248) vs 4.8% (3 of 63) (P = .13) for PVD and PCD. PVD had no independent effect on either newborn hospital mortality or severe neonatal composite morbidity. A policy of planned vaginal delivery of very preterm twins with the first twin in cephalic presentation does not increase either severe neonatal morbidity or mortality. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. The more publication, the higher impact factor: citation analysis of top nine gastroenterology and hepatology journals.

    PubMed

    Karimi Elizee, Pegah; Karimzadeh Ghassab, Romina; Raoofi, Azam; Miri, Seyyed Mohammad

    2012-12-01

    The impact factor (IF), as the most important criterion for journal's quality measurement, is affected by the self-citation and number of publications in each journal. To find out the relationship between the number of publications and self-citations in a journal, and their correlations with IF. Self-citations and impact factors of nine top gastroenterology and hepatology journals were assessed during the seven recent years (2005-2011) through Journal Citation Reports (JCR, ISI Thomson Reuters). Although impact factors of all journals increased during the study, five out of nine journals increased the number of publications from 2005 to 2011. There was an increase in self-citation only in the journal of HEPATOLOGY (499 in 2005 vs. 707 in 2011). Impact factors of journals (6.5 ± 3.5) were positively correlated with total number of publications (248.6 ± 91.7) (R: 0.688, P < 0.001). Besides, the self-citation rate (238.73 ± 195.317) was highly correlated with total number of publications in each journal (248.6 ± 91.7) (R: 0.861, P < 0.001). On the other hand, impact factor without self-citation (6.08 ± 3.3) had a correlation (R: 0.672, P < 0.001) with the number of published items (248.6 ± 91.7). The number of articles and self-citation have definite effects on IF of a journal and because IF is the most prominent criterion for journal's quality measurement, it would be a good idea to consider factors affecting on IF such as self-citation.

  1. Dynamics of Db isotopes formed in reactions induced by 238U, 248Cm, and 249Bk across the Coulomb barrier

    NASA Astrophysics Data System (ADS)

    Kaur, Gurjit; Sandhu, Kirandeep; Kaur, Amandeep; Sharma, Manoj K.

    2018-05-01

    The dynamical cluster decay model is employed to investigate the decay of *265Db and *267Db nuclei, formed in the 27Al+238U , 18O+249Bk , and 19F+248Cm hot fusion reactions at energies around the Coulomb barrier. First, the fission dynamics of the 27Al+238U reaction is explored by investigating the fragmentation and preformation yield of the reaction. The symmetric mass distribution of the fission fragments is observed for *265Db nucleus, when static β2 i deformations are used within hot optimum orientation approach. However, the mass split gets broaden for the use of β2 i-dynamical hot configuration of the fragments and becomes clearly asymmetric for the cold-static-deformed approach. Within the application of cold orientations of fragments, a new fission channel is observed at mass asymmetry η =0.29 . In addition to 238U-induced reaction, the work is carried out to address the fission and neutron evaporation cross sections of *267Db nucleus formed via 19F+248Cm and 18O+249Bk reactions, besides a comprehensive analysis of fusion and capture processes. Higher fusion cross sections and compound nucleus formation probabilities (PCN) are obtained for the 18O+249Bk reaction, as larger mass asymmetry in the entrance channel leads to reduced Coulomb factor. Finally, the role of sticking (IS) and nonsticking (INS) moments of inertia is analyzed for the 4 n and 5 n channels of *267Db nuclear system.

  2. Effect of photo-selective nettings on post-harvest quality and bioactive compounds in selected tomato cultivars.

    PubMed

    Selahle, Maphoko Kamogelo; Sivakumar, Dharini; Soundy, Puffy

    2014-08-01

    Photo-selective coloured netting is referred to as a 'new agro-technological' concept adopted to manipulate light quality changes that can induce favourable responses in plants. Tomato (Solanum lycopersicum L.) cultivars AlvaV, Irit and SCX 248 grown under the black net (commercial net, 25% shading) showed higher weight loss, loss of firmness, ascorbic acid content and decline in the ratio of soluble solids content/titrable acidity during post-harvest storage (low-temperature storage at 10°C and 90% relative humidity for 21 days followed by market shelf conditions at 25°C for 2 days). During post-harvest storage, lycopene, β-carotene, total phenolic content and antioxidant scavenging activity were higher in cvs AlfaV and Irit grown under the black or pearl nets. However, the β-carotene, total phenolic content and antioxidant scavenging activity were higher in SCX 248 grown under the red net during post-harvest storage. Cultivar AlfaV grown under the red and pearl nets had a higher number of odour active aroma compounds during post-harvest storage. Panellists preferred cv. AlfaV grown under the pearl nets after storage based on taste, overall appearance and firm textured fruits. Pearl photo-selective nets retained the overall fruit quality and bioactive components in cvs AlfaV and Irit during post-harvest storage. Red photo-selective nets, however, showed greater influence on retention of overall fruit quality and bioactive compounds in cv. SCX 248 during post-harvest storage. © 2013 Society of Chemical Industry.

  3. Laser effect on the 248 nm KrF transition using heavy ion beam pumping

    NASA Astrophysics Data System (ADS)

    Adonin, A.; Jacoby, J.; Turtikov, V.; Fertman, A.; Golubev, A.; Hoffmann, D. H. H.; Ulrich, A.; Varentsov, D.; Wieser, J.

    2007-07-01

    In December 2005 the first successful operation of a UV excimer laser pumped with a heavy ion beam was demonstrated at GSI. It was the first experiment in which the specific power deposition was sufficient to overcome laser threshold for a UV excimer scheme. The well known KrF* excimer laser line at λ=248 nm has been chosen for this experiment, because the wavelength is short, but still in the range of usual optical diagnostic tools and the emitted light can propagate in air without attenuation. A bunch compressed U+73238 beam with a particle energy of 250 MeV/u and about 110 ns pulse duration (FWHM) was used for this experiment. Single pulses of a beam intensity up to 2.5×109 particles per bunch were focused into the laser cell along the cavity axis. Compact spectrometers, high speed UV-photodiodes and gated CCD-cameras were used for diagnostics of the spontaneous and stimulated emission. As a main result of the experiment laser effect on the 248 nm KrF* excimer laser line has been obtained and verified by temporal and spectral narrowing of the laser line as well as the threshold behaviour and exponential growth of intensity with increasing pumping power. In summary it could be shown that the pumping power of the heavy ion beam at GSI is now sufficient to pump short wavelength lasers. It is planned to extend laser experiments in near future to the VUV range of the spectrum (λ<200 nm).

  4. Extreme Quiescent Variability of the Transient Neutron Star Low-mass X-ray Binary EXO 1745-248 in Terzan 5

    NASA Astrophysics Data System (ADS)

    Sandoval, L. E. Rivera; Wijnands, R.; Degenaar, N.; Cavecchi, Y.; Heinke, C. O.; Cackett, E. M.; Homan, J.; Altamirano, D.; Bahramian, A.; Sivakoff, G. R.; Miller, J. M.; Parikh, A. S.

    2018-06-01

    EXO 1745-248 is a transient neutron-star low-mass X-ray binary that resides in the globular cluster Terzan 5. We studied the transient during its quiescent state using 18 Chandra observations of the cluster acquired between 2003 and 2016. We found an extremely variable source, with a luminosity variation in the 0.5-10 keV energy range of ˜3 orders of magnitude (between 3 × 1031 erg s-1 and 2 × 1034 erg s-1) on time scales from years down to only a few days. Using an absorbed power-law model to fit its quiescent spectra, we obtained a typical photon index of ˜1.4, indicating that the source is even harder than during outburst and much harder than typical quiescent neutron stars if their quiescent X-ray spectra are also described by a single power-law model. This indicates that EXO 1745-248 is very hard throughout the entire observed X-ray luminosity range. At the highest luminosity, the spectrum fits better when an additional (soft) component is added to the model. All these quiescent properties are likely related to strong variability in the low-level accretion rate in the system. However, its extreme variable behavior is strikingly different from the one observed for other neutron star transients that are thought to still accrete in quiescence. We compare our results to these systems. We also discuss similarities and differences between our target and the transitional millisecond pulsar IGR J18245-2452, which also has hard spectra and strong variability during quiescence.

  5. 26 CFR 1.248-1T - Election to amortize organizational expenditures (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of fact which must be determined in each case in light of all the circumstances of the particular... corporation comes into existence on the date of its incorporation. Mere organizational activities, such as the...

  6. 2012 Survey of Active Duty Spouses: Tabulations of Responses

    DTIC Science & Technology

    2013-09-30

    246 j. Attending religious/ spiritual services ................................................... 248 k. Accepting stressful...258 p. Participating in religious/ spiritual activities .......................................... 260 q. Defining the family...life .............................................................. 276 57. Seeking Spiritual Support: Constructed from Q57j, p, and s. Subfactor of

  7. The Chicago-Iowa City passenger rail program : fact sheet.

    DOT National Transportation Integrated Search

    2011-02-23

    Project costs : Overall cost: $310 million : Costs allocated between Iowa and Illinois : Iowa and Illinois submitted a joint application for $248 : million (up to 80 percent of the project cost) from the : High-Speed Intercity Passenger R...

  8. Diffusion of Educational Knowledge Through Journals: Gatekeepers' Selection Criteria

    ERIC Educational Resources Information Center

    Silverman, Robert J.

    1978-01-01

    Report is made of a survey of 248 editors representing scholarly, professional, association, and research journals in regard to their editorial role, criteria for accepting or rejecting manuscripts, and selection of editorial boards and reviewers. (Author/MJB)

  9. 76 FR 60836 - Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... at (202) 523-5843 or by e-mail at [email protected] . A & D International Logistics, Corp. (NVO), 248 NW... & General Manager (Qualifying Individual), Application Type: QI Change. American Royal International, Inc.../ General Manager (Qualifying Individual), Beverly Franklin, CFO/ Secretary (Qualifying Individual...

  10. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  11. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  12. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  13. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  14. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  15. 30 CFR 756.13 - Approval of the Navajo Nation's abandoned mine land plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [60 FR 33724, June 29, 1995, as amended at 61 FR 6508, Feb...

  16. 30 CFR 756.13 - Approval of the Navajo Nation's abandoned mine land plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [60 FR 33724, June 29, 1995, as amended at 61 FR 6508, Feb...

  17. 30 CFR 756.13 - Approval of the Navajo Nation's abandoned mine land plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [60 FR 33724, June 29, 1995, as amended at 61 FR 6508, Feb...

  18. 30 CFR 756.13 - Approval of the Navajo Nation's abandoned mine land plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [60 FR 33724, June 29, 1995, as amended at 61 FR 6508, Feb...

  19. 30 CFR 756.13 - Approval of the Navajo Nation's abandoned mine land plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Mining Reclamation and Enforcement, Albuquerque Field Office, 505 Marquette Ave., NW., Suite 1200, Albuquerque, NM 87102, Telephone: (505) 248-5070. [60 FR 33724, June 29, 1995, as amended at 61 FR 6508, Feb...

  20. Suicide in serial killers.

    PubMed

    Lester, David; White, John

    2010-02-01

    In a sample of 248 killers of two victims in America from 1900 to 2005, obtained from an encyclopedia of serial killers by Newton (2006), those completing suicide did not differ in sex, race, or the motive for the killing from those who were arrested.

  1. 51. Photocopy of photograph (original print located in LBNL Photo ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    51. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 22, 1950. BEV-248. INTERIOR OF BEVATRON BUILDING. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

  2. 75 FR 65706 - Fifteenth Plenary Meeting, RTCA Special Committee 205/EUROCAE WG 71: Software Considerations in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ..., Software Considerations in Airborne Systems and Equipment Certification ED-94B/DO-248B, Final Annual Report for Clarification of ED-94B/DO-178B ``Software Considerations In Airborne Systems And Equipment...

  3. The Quantum Yield of NO3 from Peroxyacetyl Nitrate Photolysis

    NASA Technical Reports Server (NTRS)

    Mazely, Troy L.; Friedl, Randall R.; Sander, Stanley P.

    1997-01-01

    Peroxyacetyl nitrate (PAN) vapor was photolyzed at 248nm and the NO3 photoproduct was detected by laser induced fluorescence. The excited state flourescence contributions were investigated and a data analysis methodology was established to minimize their effects.

  4. 48 CFR 538.7002 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contracts containing information technology SINs, and Schedule 84 contracts. A listing of the participating... Consolidated Schedule contracts containing information technology SINs, and Schedule 84 contracts, is available... institution of higher education). (c) Pub.L. 110-248, The Local Preparedness Acquisition Act, authorizes the...

  5. 48 CFR 538.7002 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... contracts containing information technology SINs, and Schedule 84 contracts. A listing of the participating... Consolidated Schedule contracts containing information technology SINs, and Schedule 84 contracts, is available... institution of higher education). (c) Pub.L. 110-248, The Local Preparedness Acquisition Act, authorizes the...

  6. 48 CFR 538.7002 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... contracts containing information technology SINs, and Schedule 84 contracts. A listing of the participating... Consolidated Schedule contracts containing information technology SINs, and Schedule 84 contracts, is available... institution of higher education). (c) Pub.L. 110-248, The Local Preparedness Acquisition Act, authorizes the...

  7. 27 CFR 24.248 - Processes authorized for the treatment of wine, juice, and distilling material.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... vinous character of the wine(2) None of the stripping solution may migrate into the wine. Reverse osmosis....2910. 1 This process must be done on distilled spirits plant premises. However, reverse osmosis, under...

  8. 27 CFR 24.248 - Processes authorized for the treatment of wine, juice, and distilling material.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... vinous character of the wine(2) None of the stripping solution may migrate into the wine. Reverse osmosis....2910. 1 This process must be done on distilled spirits plant premises. However, reverse osmosis, under...

  9. 27 CFR 24.248 - Processes authorized for the treatment of wine, juice, and distilling material.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... vinous character of the wine(2) None of the stripping solution may migrate into the wine. Reverse osmosis....2910. 1 This process must be done on distilled spirits plant premises. However, reverse osmosis, under...

  10. 248 E. South Water, August 2010, Lindsay Light Radiological Survey

    EPA Pesticide Factsheets

    The field gamma measurements within the excavation andthe spoil materials generated during the excavation process did not exceed the respective thresholdvalues previously stated and ranged from a minimum of 1,600 cpm to a maximum of 2,900 cpm.

  11. Face Recognition From One Example View.

    DTIC Science & Technology

    1995-09-01

    Proceedings, International Workshop on Automatic Face- and Gesture-Recognition, pages 248{253, Zurich, 1995. [32] Yael Moses, Shimon Ullman, and Shimon...recognition. Journal of Cognitive Neuroscience, 3(1):71{86, 1991. [49] Shimon Ullman and Ronen Basri. Recognition by linear combinations of models

  12. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... circulation magazine, billboard advertisements and publicly available Web sites that are not directed to... subdivision or agency, or other entity. (q) Pre-existing business relationship—(1) In general. The term “pre...

  13. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... circulation magazine, billboard advertisements and publicly available Web sites that are not directed to... subdivision or agency, or other entity. (q) Pre-existing business relationship—(1) In general. The term “pre...

  14. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... circulation magazine, billboard advertisements and publicly available Web sites that are not directed to... subdivision or agency, or other entity. (q) Pre-existing business relationship—(1) In general. The term “pre...

  15. The Omics Revolution in Agricultural Research

    EPA Science Inventory

    The Agrochemicals Division cosponsored the 13th International Union of Pure and Applied Chemistry International Congress of Pesticide Chemistry held as part of the 248th National Meeting and Exposition of the American Chemical Society in San Francisco, CA, USA, August 10–14...

  16. 30 CFR 550.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... permit. Briefly describe the major discharges and methods you will use for compliance. (d) Modeling report. A modeling report or the modeling results (if you modeled the discharges of your projected solid...

  17. 30 CFR 550.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... permit. Briefly describe the major discharges and methods you will use for compliance. (d) Modeling report. A modeling report or the modeling results (if you modeled the discharges of your projected solid...

  18. 30 CFR 550.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... permit. Briefly describe the major discharges and methods you will use for compliance. (d) Modeling report. A modeling report or the modeling results (if you modeled the discharges of your projected solid...

  19. 21 CFR 558.248 - Erythromycin thiocyanate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disease during periods of stress Feed for 2 d before stress and 3 to 6 d after stress; withdraw 24 h... during periods of stress Feed for 2 d before stress and 3 to 6 d after stress (vi) 185 1. Chickens; as an...

  20. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  1. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  2. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  3. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  4. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  5. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  6. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  7. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  8. 26 CFR 1.581-3 - Definition of bank prior to September 28, 1962.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... exercising fiduciary powers similar to those permitted to national banks under section 11(k) of the Federal Reserve Act (38 Stat. 262; 12 U.S.C. 248(k)), and which is subject by law to supervision and examination...

  9. Investigation of contributing factors regarding wrong-way driving on freeways.

    DOT National Transportation Integrated Search

    2012-10-01

    In Illinois, there were 217 wrong-way crashes on freeways from 2004 to 2009, resulting in 44 killed and : 248 injured. This research project sought to determine the contributing factors to wrong-way crashes on : freeways and to develop promising, cos...

  10. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this... original sentence is not interrupted by a new conviction (e.g., YCA; NARA; Mexican or Canadian treaty cases...

  11. 21 CFR 558.248 - Erythromycin thiocyanate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... disease during periods of stress Feed for 2 d before stress and 3 to 6 d after stress; withdraw 24 h... during periods of stress Feed for 2 d before stress and 3 to 6 d after stress (vi) 185 1. Chickens; as an...

  12. 17 CFR 248.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... about individuals who obtain financial products or services primarily for personal, family, or household... agricultural purposes. This part applies to brokers, dealers, and investment companies, as well as to investment advisers that are registered with the Commission. It also applies to foreign (non-resident...

  13. ISS Passes over Hurricane_Irma_GMT248-1510

    NASA Image and Video Library

    2017-09-05

    The International Space Station’s external cameras captured a dramatic view of Hurricane Irma as it moved across the Atlantic Ocean Sept. 5. The National Hurricane Center had recently upgraded Irma to a Category 5 storm with hurricane warnings issued across the Caribbean.

  14. Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor.

    PubMed

    Cannata, David J; Finkelstein, David I; Gantois, Ilse; Teper, Yaroslav; Drago, John; West, Jan M

    2009-01-01

    We generated a mouse line with a missense mutation (S248F) in the gene (CHRNA4) encoding the alpha4 subunit of neuronal nicotinic acetylcholine receptor (nAChR). Mutant mice demonstrate brief nicotine induced dystonia that resembles the clinical events seen in patients with the same mutation. Drug-induced dystonia is more pronounced in female mice, thus our aim was to determine if the S248F mutation changed the properties of fast- and slow-twitch muscle fibres from female mutant mice. Reverse transcriptase-PCR confirmed CHRNA4 gene expression in the brain but not skeletal muscles in normal and mutant mice. Ca(2+) and Sr(2+) force activation curves were obtained using skinned muscle fibres prepared from slow-twitch (soleus) and fast-twitch (EDL) muscles. Two significant results were found: (1) the (pCa(50) - pSr(50)) value from EDL fibres was smaller in mutant mice than in wild type (1.01 vs. 1.30), (2) the percentage force produced at pSr 5.5 was larger in mutants than in wild type (5.76 vs. 0.24%). Both results indicate a shift to slow-twitch characteristics in the mutant. This conclusion is supported by the identification of the myosin heavy chain (MHC) isoforms. Mutant EDL fibres expressed MHC I (usually only found in slow-twitch fibres) as well as MHC IIa. Despite the lack of spontaneous dystonic events, our findings suggest that mutant mice may be having subclinical events or the mutation results in a chronic alteration to muscle neural input.

  15. Induction of HER2 Immunity in Outbred Domestic Cats by DNA Electrovaccination

    PubMed Central

    Gibson, Heather; Veenstra, Jesse; Jones, Richard; Vaishampayan, Ulka; Sauerbrey, Michele; Bepler, Gerold; Lum, Lawrence; Reyes, Joyce; Weise, Amy; Wei, Wei-Zen

    2015-01-01

    Domestic cats share human living environments and genetic traits. They develop spontaneous feline mammary carcinoma (FMC) with histopathology similar to human breast cancer. HER2 and AKT phosphorylation was demonstrated in primary FMC by immunoblot, indicating HER2 as a therapeutic target. FMC lines K12 and K248 expressing HER1, HER2 and HER3 were sensitive to receptor tyrosine kinase (RTK) inhibitors gefitinib and lapatinib. To test HER2 vaccine response in cats, purpose-bred, healthy cats were electrovaccinated with heterologous (xenogeneic) or point-mutated feline HER2 DNA. T-cell reactivity to feline self-HER2 was detected in 4 of 10 cats that received bear HER2, human/rat fusion HER2 (E2Neu) or mutant feline HER2 (feHER2-K) which contains a single amino acid substitution. The variable T-cell responses may resemble that in the genetically heterogeneous human population. All immune sera to heterologous HER2 recognized feline HER2 expressed in 3T3 cells (3T3/HER2), but not that in FMC K12 or K248. Immune sera to mutant pfeHER2-K bound 3T3/HER2 cells weakly, but they demonstrated better recognition of K12 and K248 cells that also express HER1 and HER3, suggesting distinct HER2 epitopes displayed by FMC that may be simulated by feHER2-K. In summary, HER2 DNA electroporation overcomes T-cell immune tolerance in ~40% healthy cats and induces antibodies with distinct specificity. Vaccination studies in domestic cats can expedite vaccine iteration to guide human vaccine design and better predict outcome, with the added benefit of helping feline mammary tumor patients. PMID:25711535

  16. Adjunctive Inferior Vena Cava Filter Placement for Acute Pulmonary Embolism

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jha, V. M., E-mail: vjha@mfa.gwu.ed; Lee-Llacer, J.; Williams, J.

    Inferior vena cava (IVC) filters are sometimes placed as an adjunct to full anticoagulation in patients with significant pulmonary embolism (PE). We aimed to determine the prevalence of adjunctive IVC filter placement in individuals diagnosed with PE, as well as the effect of adjunctive filter placement on mortality in patients with right heart strain associated with PE. This was a retrospective study of patients with acute PE treated with full anticoagulation admitted to a single academic medical center. Information abstracted from patient charts included presence or absence of right heart strain and of deep-vein thrombosis, and whether or not anmore » IVC filter was placed. The endpoint was in-hospital mortality. Over 2.75 years, we found that 248 patients were diagnosed with acute PE, with an in-hospital mortality rate of 4.4%. The prevalence of adjunctive IVC filter placement was 13.3% (33 of 248), and the prevalence of documented right heart strain was 27.0% (67 of 248). In-hospital mortality was 10.2% in the non-filter-treated group (5 of 49), whereas there were no deaths in the filter-treated group (0 of 18); however, the difference was not statistically significant (P = 0.37). Both the presence of deep-vein thrombosis and of right heart strain increased the likelihood that an adjunctive IVC filter was placed (P < 0.0001 and P < 0.001, respectively). At our institution, patients were treated with IVC filters in addition to anticoagulation in 13.3% of cases of acute PE. Prospective studies or large clinical registries should be conducted to clarify whether this practice improves outcomes.« less

  17. Studies on the synthesis of isotopes of superheavy element Lv (Z = 116)

    NASA Astrophysics Data System (ADS)

    Santhosh, K. P.; Safoora, V.

    2017-11-01

    The probable projectile-target combinations for the synthesis of superheavy nucleus 296Lv found in the cold valley of 296Lv have been identified by studying the interaction barrier of the colliding nuclei, probability of compound nucleus formation, P_{CN}, and survival probability W_{sur}. At energies near and above the Coulomb barrier, the capture, fusion and evaporation residue (ER) cross sections for the probable combinations for the hot and cold fusion reactions are systematically investigated. By considering intensities of the projectile beams, availabilities of the targets and half lives of the colliding nuclei, the combination 48Ca+248Cm is found to be the most probable projectile-target pair for the synthesis of 296Lv. The calculated maximum value of 2n, 3n, 4n and 5n channel cross section for the reaction 48Ca+248Cm are 0.599 pb, 5.957 pb, 4.805 pb, and 0.065 pb, respectively. Moreover, the production cross sections for the synthesis of isotopes 291-295,298Lv using 48Ca projectile on 243-247,250Cm targets are calculated. Among these reactions, the reactions 48Ca+247Cm → 295Lv and 48Ca+250Cm → 298Lv have maximum production cross section in 3n (10.697 pb) and 4n (12.006 pb) channel, respectively. Our studies on the SHE Lv using the combinations 48Ca+245Cm → 293Lv and 48Ca+248Cm → 296Lv are compared with available experimental data and with other theoretical studies. Our studies are in agreement with experimental data and we hope that these studies will be a guide for the future experiments to synthesize the isotopes of Lv.

  18. Determinants of reinforcer accumulation during an operant task.

    PubMed

    McFarland, J M; Lattal, K A

    2001-11-01

    Responses by rats on an earn lever made available food pellets that were delivered to a food cup by responses on a second, collect, lever. The rats could either collect and immediately consume or accumulate (defined as the percentage of multiple earn responses and as the number of pellets earned before a collect response) earned pellets. In Experiment 1, accumulation varied as a function of variations in the earn or collect response requirements and whether the earn and collect levers were proximal (31 cm) or distal (248 cm) to one another. Some accumulation occurred under all but one of the conditions, but generally was higher when the earn and collect levers were distal to one another, particularly when the earn response requirement was fixed-ratio (FR) 1. In Experiment 2, the contributions of responses and time to accumulation were assessed by comparing an FR 20 earn response requirement to a condition in which only a single earn response was required at the end of a time interval nominally yoked to the FR interval. When 248 cm separated the earn and collect levers, accumulation was always greater in the FR condition, and it was not systematically related to reinforcement rate. In Experiment 3, increasing the earn response requirement with a progressive-ratio schedule that reset only with a collect response increased the likelihood of accumulation when the collect and earn levers were 248 cm apart, even though such accumulation increased the next earn response requirement. Reinforcer accumulation is an understudied dimension of operant behavior that relates to the analysis of such phenomena as hoarding and self-control, in that they too involve accumulating versus immediately collecting or consuming reinforcers.

  19. Determinants of reinforcer accumulation during an operant task.

    PubMed Central

    McFarland, J M; Lattal, K A

    2001-01-01

    Responses by rats on an earn lever made available food pellets that were delivered to a food cup by responses on a second, collect, lever. The rats could either collect and immediately consume or accumulate (defined as the percentage of multiple earn responses and as the number of pellets earned before a collect response) earned pellets. In Experiment 1, accumulation varied as a function of variations in the earn or collect response requirements and whether the earn and collect levers were proximal (31 cm) or distal (248 cm) to one another. Some accumulation occurred under all but one of the conditions, but generally was higher when the earn and collect levers were distal to one another, particularly when the earn response requirement was fixed-ratio (FR) 1. In Experiment 2, the contributions of responses and time to accumulation were assessed by comparing an FR 20 earn response requirement to a condition in which only a single earn response was required at the end of a time interval nominally yoked to the FR interval. When 248 cm separated the earn and collect levers, accumulation was always greater in the FR condition, and it was not systematically related to reinforcement rate. In Experiment 3, increasing the earn response requirement with a progressive-ratio schedule that reset only with a collect response increased the likelihood of accumulation when the collect and earn levers were 248 cm apart, even though such accumulation increased the next earn response requirement. Reinforcer accumulation is an understudied dimension of operant behavior that relates to the analysis of such phenomena as hoarding and self-control, in that they too involve accumulating versus immediately collecting or consuming reinforcers. PMID:11768714

  20. Ratio

    NASA Astrophysics Data System (ADS)

    Webster, Nathan A. S.; Pownceby, Mark I.; Madsen, Ian C.; Studer, Andrew J.; Manuel, James R.; Kimpton, Justin A.

    2014-12-01

    Effects of basicity, B (CaO:SiO2 ratio) on the thermal range, concentration, and formation mechanisms of silico-ferrite of calcium and aluminum (SFCA) and SFCA-I iron ore sinter bonding phases have been investigated using an in situ synchrotron X-ray diffraction-based methodology with subsequent Rietveld refinement-based quantitative phase analysis. SFCA and SFCA-I phases are the key bonding materials in iron ore sinter, and improved understanding of the effects of processing parameters such as basicity on their formation and decomposition may assist in improving efficiency of industrial iron ore sintering operations. Increasing basicity significantly increased the thermal range of SFCA-I, from 1363 K to 1533 K (1090 °C to 1260 °C) for a mixture with B = 2.48, to ~1339 K to 1535 K (1066 °C to 1262 °C) for a mixture with B = 3.96, and to ~1323 K to 1593 K (1050 °C to 1320 °C) at B = 4.94. Increasing basicity also increased the amount of SFCA-I formed, from 18 wt pct for the mixture with B = 2.48 to 25 wt pct for the B = 4.94 mixture. Higher basicity of the starting sinter mixture will, therefore, increase the amount of SFCA-I, considered to be more desirable of the two phases. Basicity did not appear to significantly influence the formation mechanism of SFCA-I. It did, however, affect the formation mechanism of SFCA, with the decomposition of SFCA-I coinciding with the formation of a significant amount of additional SFCA in the B = 2.48 and 3.96 mixtures but only a minor amount in the highest basicity mixture. In situ neutron diffraction enabled characterization of the behavior of magnetite after melting of SFCA produced a magnetite plus melt phase assemblage.

  1. Unemployment and initiation of psychotropic medication: a case-crossover study of 2 348 552 Norwegian employees.

    PubMed

    Kaspersen, Silje L; Pape, Kristine; Ose, Solveig O; Gunnell, David; Bjørngaard, Johan Håkon

    2016-11-01

    The study investigated initiation of psychotropic medication in relation to unemployment in the months before, during and after job loss, to detect the period of greatest risk. The Norwegian working population in 2004 (N=2 348 552) was observed from 2005 to 2010 through administrative registries linked to the Norwegian Prescription Database. A case-crossover design was used to analyse within-person relative risk of incident purchases of prescribed psychotropic drugs in relation to timing of unemployment. Control periods were defined 12, 24 and 36 months before the drug purchase. Supplementary analyses were performed on medication for cardiovascular disease, diabetes, obesity, thyroid disorder, pain and musculoskeletal conditions. Purchases of all psychotropic drugs increased 1-3 months before job loss. Antidepressants had the highest estimate in the month before job loss (OR 2.68, 95% CIs 2.39 to 3.01), followed by hypnotics/sedatives (OR 2.21, 95% CI 1.97 to 2.48), anxiolytics (OR 2.18, 95% CI 1.91 to 2.48) and antipsychotics (OR 2.09, 95% CI 1.76 to 2.48). Rises were greatest in men. Risk of starting psychotropic medication remained raised during a spell of unemployment, but returned to close-to-baseline levels following re-employment. Drugs used to treat somatic and pain conditions showed similar trends but with weaker associations. Concerns about impending unemployment may influence mental health several months prior to job loss, especially around the time of notification. The clinical implications of this might be a strengthening of preventive health initiatives early in the unemployment process. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. Platelet count and platelet indices in women with preeclampsia.

    PubMed

    AlSheeha, Muneera A; Alaboudi, Rafi S; Alghasham, Mohammad A; Iqbal, Javed; Adam, Ishag

    2016-01-01

    Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia. To compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls. Qassim Hospital, Kingdom of Saudi Arabia. A case-control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls. There was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC) curves, the PC cutoff was 248.0×10 3 /µL for diagnosis of pre-eclampsia ( P =0.019; the area under the ROC curve was 62.4%). Binary regression suggests that women with PC <248.010×10 3 /µL were at higher risk of preeclampsia (odds ratio =2.2, 95% confidence interval =1.08-4.6, P =0.03). The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia ( P =0.035, the area under the ROC curve was 62.2%). PC <248.010×10 3 /µL and PC to MPV ratio 31.2 are valid predictors of preeclampsia.

  3. The research progress of metrological 248nm deep ultraviolent microscope inspection device

    NASA Astrophysics Data System (ADS)

    Wang, Zhi-xin; Li, Qi; Gao, Si-tian; Shi, Yu-shu; Li, Wei; Li, Shi

    2016-01-01

    In lithography process, the precision of wafer pattern to a large extent depends on the geometric dimensioning and tolerance of photomasks when accuracy of lithography aligner is certain. Since the minimum linewidth (Critical Dimension) of the aligner exposing shrinks to a few tens of nanometers in size, one-tenth of tolerance errors in fabrication may lead to microchip function failure, so it is very important to calibrate these errors of photomasks. Among different error measurement instruments, deep ultraviolent (DUV) microscope because of its high resolution, as well as its advantages compared to scanning probe microscope restrained by measuring range and scanning electron microscope restrained by vacuum environment, makes itself the most suitable apparatus. But currently there is very few DUV microscope adopting 248nm optical system, means it can attain 80nm resolution; furthermore, there is almost no DUV microscope possessing traceable calibration capability. For these reason, the National Institute of Metrology, China is developing a metrological 248nm DUV microscope mainly consists of DUV microscopic components, PZT and air supporting stages as well as interferometer calibration framework. In DUV microscopic component, the Köhler high aperture transmit condenser, DUV splitting optical elements and PMT pinhole scanning elements are built. In PZT and air supporting stages, a novel PZT actuating flexural hinge stage nested separate X, Y direction kinematics and a friction wheel driving long range air supporting stage are researched. In interferometer framework, a heterodyne multi-pass interferometer measures XY axis translation and Z axis rotation through Zerodur mirror mounted on stage. It is expected the apparatus has the capability to calibrate one dimensional linewidths and two dimensional pitches ranging from 200nm to 50μm with expanded uncertainty below 20nm.

  4. 24 CFR 248.221 - Approval of a plan of action that involves termination of low income affordability restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... materially increase economic hardship for current tenants (and will not in any event result in: (1) A monthly..., the Commissioner may provide housing assistance to tenants if such assistance is not essential to the...

  5. Urban Principal Leadership Skill Proficiency and Student Achievement

    ERIC Educational Resources Information Center

    Winn, Pam; Erwin, Sue; Gentry, Jim; Cauble, Mary

    2009-01-01

    Because of the importance of developing highly skilled urban school leaders, statewide assessments of 248 urban Texas public school administrators were analyzed to determine principal confidence levels in leadership skill domains identified by the National Policy Board of Educational Administration (NPBEA). Important findings indicate differences…

  6. 76 FR 41510 - Draft Environmental Impact Statement and Habitat Conservation Plan for Commercial Wind Energy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ...] Draft Environmental Impact Statement and Habitat Conservation Plan for Commercial Wind Energy... regional- level construction, operation, and maintenance associated with multiple commercial wind energy...; Attention: Laila Lienesch; Facsimile: 505/248-6922 (Attention: Laila Lienesch); E-Mail: WindEnergy...

  7. 24 CFR 248.405 - Grants for building resident capacity and funding predevelopment costs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of a resident organization or council, conducting democratic elections, training, leadership..., including third party costs for training, development consulting, legal, appraisal, accounting... agreement to sell the housing to a resident organization or nonprofit organization. (3) Phase-in of grant...

  8. 2011 Aerospace Medical Certification Statistical Handbook

    DTIC Science & Technology

    2013-01-01

    reconstruction§ 14,769 2.48 Asthma 12,777 2.15 Neuroses – hysterical, hysterical-conversion type, hysterical- dissociative type, phobic, neurasthenic...functional or physiological 10,086 1.70 Traumatic brain injury, concussion, amnesia , coma (30 minutes or more), loss of memory 10,010 1.68 * Excludes

  9. Body Mass Bias in a Combat Fitness Test

    DTIC Science & Technology

    2011-02-07

    Allometric scaling of isokinetic peak torque: The Nebraska Wrestling Study. European Journal of Applied Physiology, 80, 240–248. White, C. R...applied to the Movement and 3-mi run times after converting times to velocity (in meters ). The estimated metabolic rate mass coefficients were

  10. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... marketing communications that the service provider may send to the investment company's consumers; and the... response to this communication. (iii) A registered investment adviser makes a marketing call to the... marketing solicitations would respond to the consumer-initiated communication about mutual funds. (4...

  11. Speech Processing.

    DTIC Science & Technology

    1983-05-01

    The VDE system developed had the capability of recognizing up to 248 separate words in syntactic structures. 4 The two systems described are isolated...size, weight, and power consumption of VDE devices (See Fig. 19). 8. DUU and NATU Advisory Groups on Voice Technology At the present time, two major

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fahim, Farah; Deptuch, Grzegorz; Shenai, Alpana

    The Vertically Integrated Photon Imaging Chip - Large, (VIPIC-L), is a large area, small pixel (65μm), 3D integrated, photon counting ASIC with zero-suppressed or full frame dead-time-less data readout. It features data throughput of 14.4 Gbps per chip with a full frame readout speed of 56kframes/s in the imaging mode. VIPIC-L contain 192 x 192 pixel array and the total size of the chip is 1.248cm x 1.248cm with only a 5μm periphery. It contains about 120M transistors. A 1.3M pixel camera module will be developed by arranging a 6 x 6 array of 3D VIPIC-L’s bonded to a largemore » area silicon sensor on the analog side and to a readout board on the digital side. The readout board hosts a bank of FPGA’s, one per VIPIC-L to allow processing of up to 0.7 Tbps of raw data produced by the camera.« less

  13. The influence of adding fats of varying saturation on the glycaemic response of white bread.

    PubMed

    Henry, C Jeya K; Lightowler, Helen J; Newens, Katie J; Pata, Nicki

    2008-02-01

    The aim of this study was to examine the effect of three different fats of varying degrees of saturation on the glycaemic response of white bread. Standard white bread was served alone or with 30 g butter, 24.8 g olive oil or 24.8 g grape-seed oil. On separate occasions, 15 subjects consumed the four test foods and reference food (glucose) in 50 g available carbohydrate amounts. Capillary blood glucose was measured from finger-prick samples in fasted subjects (-5 and 0 min) and at 15, 30, 45, 60, 90 and 120 min after starting to eat. All fats lowered the glycaemic response of bread; however, no significant differences in glycaemic index were recorded between the types of fat used when ingested with bread. The results of the present study suggest that the glycaemic response of bread can be lowered using any type of fat; therefore, the use of unsaturated fat is recommended for its potential lipidaemic advantage.

  14. PROBING THE MSP PRENATAL STAGE: THE OPTICAL IDENTIFICATION OF THE X-RAY BURSTER EXO 1745-248 IN TERZAN 5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ferraro, F. R.; Pallanca, C.; Lanzoni, B.

    2015-07-01

    We report on the optical identification of the neutron star burster EXO 1745-248 in Terzan 5. The identification was performed by exploiting Hubble Space Telescope/Advanced Camera for Surveys images acquired in Director's Discretionary Time shortly after (approximately one month) the Swift detection of the X-ray burst. The comparison between these images and previous archival data revealed the presence of a star that is currently brightened by ∼3 mag, consistent with expectations during an X-ray outburst. The centroid of this object well agrees with the position, in the archival images, of a star located in the turn-off/sub-giant-branch region of Terzan 5.more » This supports the scenario that the companion should have recently filled its Roche Lobe. Such a system represents the prenatal stage of a millisecond pulsar, an evolutionary phase during which heavy mass accretion on the compact object occurs, thus producing X-ray outbursts and re-accelerating the neutron star.« less

  15. Investigation of heavy-ion fusion with deformed surface diffuseness: Actinide and lanthanide targets

    NASA Astrophysics Data System (ADS)

    Alavi, S. A.; Dehghani, V.

    2017-05-01

    By using a deformed Broglia-Winther nuclear interaction potential in the framework of the WKB method, the near- and above-barrier heavy-ion-fusion cross sections of 16O with some lanthanides and actinides have been calculated. The effect of deformed surface diffuseness on the nuclear interaction potential, the effective interaction potential at distinct angle, barrier position, barrier height, cross section at each angles, and fusion cross sections of 16O+147Sm,150Nd,154Sm , and 166Er and 16O+232Th,238U,237Np , and 248Cm have been studied. The differences between the results obtained by using deformed surface diffuseness and those obtained by using constant surface diffuseness were noticeable. Good agreement between experimental data and theoretical calculation with deformed surface diffuseness were observed for 16O+147Sm,154Sm,166Er,238U,237Np , and 248Cm reactions. It has been observed that deformed surface diffuseness plays a significant role in heavy-ion-fusion studies.

  16. Absolute I(asterisk) quantum yields for the ICN A state by diode laser gain-vs-absorption spectroscopy

    NASA Technical Reports Server (NTRS)

    Hess, Wayne P.; Leone, Stephen R.

    1987-01-01

    Absolute I(asterisk) quantum yields have been measured as a function of wavelength for room temperature photodissociation of the ICN A state continuum. The yields are obtained by the technique of time-resolved diode laser gain-vs-absorption spectroscopy. Quantum yields are evaluated at seven wavelengths from 248 to 284 nm. The yield at 266 nm is 66.0 + or - 2 percent and it falls off to 53.4 + or - 2 percent and 44.0 + or - 4 percent at 284 and 248 nm, respectively. The latter values are significantly higher than those obtained by previous workers using infrared fluorescence. Estimates of I(asterisk) quantum yields obtained from analysis of CN photofragment rotational distributions, as discussed by other workers, are in good agreement with the I(asterisk) yields reported here. The results are considered in conjunction with recent theoretical and experimental work on the CN rotational distributions and with previous I(asterisk) quantum yield results.

  17. Multinucleon transfer dynamics in heavy-ion collisions near Coulomb-barrier energies

    NASA Astrophysics Data System (ADS)

    Niu, Fei; Chen, Peng-Hui; Guo, Ya-Fei; Ma, Chun-Wang; Feng, Zhao-Qing

    2017-12-01

    Multinucleon transfer reactions near barrier energies have been investigated with a multistep model based on the dinuclear system (DNS) concept, in which the capture of two colliding nuclei, the transfer dynamics, and the deexcitation process of primary fragments are described by an analytical formula, diffusion theory, and a statistical model, respectively. The nucleon transfer takes place after forming the DNS and is coupled to the dissipation of relative motion energy and angular momentum by solving a set of microscopically derived master equations within the potential energy surface. Specific reactions of Ca,4840+124Sn , 40Ca(40Ar,58Ni)+232Th , 40Ca(58Ni)+238U , and Ca,4840(58Ni)+248Cm near barrier energies are investigated. It is found that fragments are produced by multinucleon transfer reactions with maximal yields along the β -stability line. The isospin relaxation is particularly significant in the process of fragment formation. The incident energy dependence of heavy target-like fragments in the reaction of 58Ni+248Cm is analyzed thoroughly.

  18. Structural-modification mechanism for polyimide-doped poly(tetrafluoroethylene)at subthreshold fluences using 248 nm radiation

    NASA Astrophysics Data System (ADS)

    Davis, C. R.; Snyder, R. W.; Egitto, F. D.; D'Couto, G. C.; Babu, S. V.

    1994-09-01

    Single-photon excimer laser ablation of neat poly(tetrafluoroethylene) (PTFE) is not observed at emissions in the 'quartz' UV, i.e., from about 190-380 nm. However, it has been successfully demonstrated that, when the fluoropolymer is doped with small quantities of polyimide (PI), ablation in the quartz UV, e.g., at 248 and 308 nm and pulse widths of about 25 ns, is readily achieved. When PI-PTFE blends are exposed to subthreshold fluences, considerable changes in surface topography occur although clearly defined structures, e.g., pits, are not formed. Using photoacoustic infrared spectroscopy to evaluate surface and bulk chemical changes to blends exposed to subthreshold excimer laser fluences, is less than 100 mJ/sq cm, it is shown that PI (1) is distributed throughout the bulk and resides at the surface and (2) is selectively absorbing the high-energy photons and as a result being preferentially removed from the surface.

  19. EARLY CHILDHOOD PEREFCTIONISM

    PubMed Central

    Halmi, Katherine A.; Bellace, Dara; Berthod, Samantha; Ghosh, Samiran; Berrettini, Wade; Brandt, Harry A.; Bulik, Cynthia M.; Crawford, Steve; Fichter, Manfred M.; Johnson, Craig L.; Kaplan, Allan; Kaye, Walter H.; Thornton, Laura; Treasure, Janet; Woodside, D. Blake; Strober, Michael

    2012-01-01

    Objective To examine childhood perfectionism in anorexia nervosa (AN) restricting (RAN), purging (PAN), and binge eating with or without purging (BAN) subtypes. Method The EATATE, a retrospective assessment of childhood perfectionism, and the Eating Disorder Inventory (EDI-2) were administered to 728 AN participants. Results EATATE responses revealed General Childhood Perfectionism, 22.3% of 333 with RAN, 29.2% of 220 with PAN, and 24.8% of 116 with BAN; School Work Perfectionism, 31.2% with RAN, 30.4% with PAN, and 24.8% with BAN; Childhood Order and Symmetry, 18.7% with RAN, 21.7% with PAN, and 17.8% with BAN; and Global Childhood Rigidity, 42.6% with RAN, 48.3% with PAN and 48.1% with BAN. Perfectionism preceded the onset of AN in all subtypes. Significant associations between EDI-2 Drive for Thinness and Body Dissatisfaction were present with four EATATE subscales. Discussion Global Childhood Rigidity was the predominate feature that preceded all AN subtypes. This may be a risk factor for AN. PMID:22488115

  20. Pressure and temperature dependences of the reaction of OH with nitric acid

    NASA Technical Reports Server (NTRS)

    Stachnik, R. A.; Molina, L. T.; Molina, M. J.

    1986-01-01

    Rate constants for the reaction of OH with HNO3 have been measured by using a laser flash photolysis resonance absorption technique at 298 and 248 K in the presence of 10-730 Torr of He, N2, and SF6. A dependence on total pressure was observed with rate constant values increasing at 298 K from 1.11 x 10 to the -13th cu cm/molecule/s at 10 Torr to 1.45 x 10 to the -13th cu cm/molecule/s at 730 Torr, and at 248 K from 1.87 x 10 to the -13th cu cm/molecule/s at 10 Torr to 3.07 x 10 to the -13th cu cm/molecule/s at 730 Torr with helium as the diluent gas. Falloff behavior occurred at lower pressures with SF6 or N2 as the diluent gas. Extrapolated zero pressure rate constants were determined and correspond to an Arrhenius activation energy of E/R = -710 K.

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