Sample records for einsteinium 253

  1. Einsteinium

    NASA Astrophysics Data System (ADS)

    Haire, Richard G.

    The discovery of einsteinium, element 99, came about during the analyses of nuclear products produced in and then recovered from test debris following a thermonuclear explosion (weapon test device, ‘Mike', November 1952) at Eniwetok Atoll in the Pacific Ocean. The uranium present in this device was subjected to a very intense neutron flux (integrated fluence of about 1024neutrons) in an extremely short time frame (few nanoseconds), which allowed a large number of multiple neutron captures with a minimal degree of decay of the products formed. Nuclei were formed with usually high neutron/proton ratios (very ‘heavy' uranium isotopes), which then rapidly beta-decayed into new, transuranium isotopes through element 100. Scientists from several U.S. Government laboratories separated and analyzed extensively the debris samplings in the following weeks. From these investigations came the discovery and identification of einsteinium and fermium. The first element was named in honor of Albert Einstein, and assigned the symbol, E (later changed to the current symbol, Es). Additional details and discussions about the discovery of this element and the scientists involved are given in several references (Thompson et al., 1954; Ghiorso et al., 1955; Fields et al., 1956; Hyde et al., 1964; Seaborg and Loveland, 1990).

  2. Chemical Properties of Elements 99 and 100 [Einsteinium and Fermium

    DOE R&D Accomplishments Database

    Seaborg, G. T.; Thompson, S. G.; Harvey, B. G.; Choppin, G. R.

    1954-07-23

    A description of some of the chemical properties and of the methods used in the separations of elements 99 [Einsteinium] and 100 [Fermium] are given. The new elements exhibit the properties expected for the tenth and eleventh actinide elements. Attempts to produce an oxidation state greater than III of element 99 have been unsuccessful. In normal aqueous media only the III state of element 100 appears to exist. The relative spacings of the elution peaks of the new elements in some separations with ion exchange resin columns are the same as the relative spacings of the homologous lanthanide elements. The results of experiments involving cation exchange resins with very concentrated hydrochloric acid eluant show that the new elements, like the earlier actinides, are more strongly complexed than the lanthanides. The new elements also exist partially as anions in concentrated hydrochloric acid, as do earlier actinide elements, and they may be partially separated from each other by means of ion exchange resins. With some eluants interesting reversals of elution positions are observed in the region Bk-Cf-99-100, indicating complex ion formation involving unusual factors.

  3. BAG PASSOUT SEALER FOR WATER-SHIELDED CAVE FACILITY (Engineering Materials)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1963-10-31

    The water-shielded cave facility is used in processing irradiated slugs for recovery of americium, curium, berkelium, californium, einsteinium, and fermium. The remotely operated, plastic-bag passout sealer is used in removing isotopic fractions for storage in the rear or for removing radioactive waste for placement in the waste storage containers. The unit is accessible by both the primary inclosure master-slaves and the service area master-slaves. (F.L.S.)

  4. Handbook of Basic Atomic Spectroscopic Data

    National Institute of Standards and Technology Data Gateway

    SRD 108 Handbook of Basic Atomic Spectroscopic Data (Web, free access)   This handbook provides a selection of the most important and frequently used atomic spectroscopic data. The compilation includes data for the neutral and singly-ionized atoms of all elements hydrogen through einsteinium (Z = 1-99). The wavelengths, intensities, and spectrum assignments are given for each element, and the data for the approximately 12,000 lines of all elements are also collected into a single table.

  5. Systematization of actinides using cluster analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kopyrin, A.A.; Terent`eva, T.N.; Khramov, N.N.

    1994-11-01

    A representation of the actinides in multidimensional property space is proposed for systematization of these elements using cluster analysis. Literature data for their atomic properties are used. Owing to the wide variation of published ionization potentials, medians are used to estimate them. Vertical dendograms are used for classification on the basis of distances between the actinides in atomic-property space. The properties of actinium and lawrencium are furthest removed from the main group. Thorium and mendelevium exhibit individualized properties. A cluster based on the einsteinium-fermium pair is joined by californium.

  6. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.

    PubMed

    Local, Andrea; Zhang, Hongying; Benbatoul, Khalid D; Folger, Peter; Sheng, Xia; Tsai, Cheng-Yu; Howell, Stephen B; Rice, William G

    2018-06-01

    APTO-253 is a phase I clinical stage small molecule that selectively induces CDKN1A (p21), promotes G 0 -G 1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans. Differential gene expression analysis identified a pharmacodynamic effect on MYC expression, as well as induction of DNA repair and stress response pathways. APTO-253 was found to elicit a concentration- and time-dependent reduction in MYC mRNA expression and protein levels. Gene ontogeny and structural informatic analyses suggested a mechanism involving G-quadruplex (G4) stabilization. Intracellular pharmacokinetic studies in AML cells revealed that APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253) 3 ]. FRET assays demonstrated that both monomeric APTO-253 and Fe(253) 3 stabilize G4 structures from telomeres, MYC, and KIT promoters but do not bind to non-G4 double-stranded DNA. Although APTO-253 exerts a host of mechanistic sequelae, the effect of APTO-253 on MYC expression and its downstream target genes, on cell-cycle arrest, DNA damage, and stress responses can be explained by the action of Fe(253) 3 and APTO-253 on G-quadruplex DNA motifs. Mol Cancer Ther; 17(6); 1177-86. ©2018 AACR . ©2018 American Association for Cancer Research.

  7. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administration. 253.4 Section 253.4 Agriculture... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS § 253.4 Administration. (a) Federal administration. Within the Department...

  8. 7 CFR 2018.253 - Indexes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Indexes. 2018.253 Section 2018.253 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE...) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information § 2018.253 Indexes. Since Rural Development does...

  9. 7 CFR 2018.253 - Indexes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Indexes. 2018.253 Section 2018.253 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE...) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information § 2018.253 Indexes. Since Rural Development does...

  10. 7 CFR 2018.253 - Indexes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Indexes. 2018.253 Section 2018.253 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE...) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information § 2018.253 Indexes. Since Rural Development does...

  11. 7 CFR 2018.253 - Indexes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Indexes. 2018.253 Section 2018.253 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE...) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information § 2018.253 Indexes. Since Rural Development does...

  12. 7 CFR 2018.253 - Indexes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Indexes. 2018.253 Section 2018.253 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE...) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information § 2018.253 Indexes. Since Rural Development does...

  13. 48 CFR 253.209 - Contractor qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contractor qualifications. 253.209 Section 253.209 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209 Contractor qualifications. ...

  14. 30 CFR 253.44 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false [Reserved] 253.44 Section 253.44 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information § 253.44 [Reserved] ...

  15. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253 Chemical...

  16. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253 Chemical...

  17. 48 CFR 253.215 - Contracting by negotiation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contracting by negotiation. 253.215 Section 253.215 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.215 Contracting by negotiation. ...

  18. 48 CFR 253.215 - Contracting by negotiation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contracting by negotiation. 253.215 Section 253.215 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.215 Contracting by negotiation. ...

  19. 48 CFR 253.215 - Contracting by negotiation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracting by negotiation. 253.215 Section 253.215 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.215 Contracting by negotiation. ...

  20. 48 CFR 253.215 - Contracting by negotiation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contracting by negotiation. 253.215 Section 253.215 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.215 Contracting by negotiation. ...

  1. 48 CFR 253.215 - Contracting by negotiation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contracting by negotiation. 253.215 Section 253.215 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.215 Contracting by negotiation. ...

  2. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253 Chemical...

  3. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253 Chemical...

  4. 40 CFR 761.253 - Chemical analysis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Chemical analysis. 761.253 Section 761.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Sample Sites, Collecting Surface Samples, and Analyzing Standard PCB Wipe Samples § 761.253 Chemical...

  5. 50 CFR 253.29 - CDQ loans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false CDQ loans. 253.29 Section 253.29 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program § 253.29 CDQ...

  6. 50 CFR 253.29 - CDQ loans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false CDQ loans. 253.29 Section 253.29 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program § 253.29 CDQ...

  7. 50 CFR 253.29 - CDQ loans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false CDQ loans. 253.29 Section 253.29 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program § 253.29 CDQ...

  8. 50 CFR 253.29 - CDQ loans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false CDQ loans. 253.29 Section 253.29 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program § 253.29 CDQ...

  9. 37 CFR 253.2 - Definition of public broadcasting entity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... broadcasting entity. 253.2 Section 253.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF... CONNECTION WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 253.2 Definition of public broadcasting entity. As used in this part, the term public broadcasting entity means a noncommercial educational broadcast...

  10. 37 CFR 253.2 - Definition of public broadcasting entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... broadcasting entity. 253.2 Section 253.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF... CONNECTION WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 253.2 Definition of public broadcasting entity. As used in this part, the term public broadcasting entity means a noncommercial educational broadcast...

  11. 48 CFR 253.209-1 - Responsible prospective contractors.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Responsible prospective contractors. 253.209-1 Section 253.209-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209-1 Responsible...

  12. 48 CFR 253.209-1 - Responsible prospective contractors.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Responsible prospective contractors. 253.209-1 Section 253.209-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209-1 Responsible...

  13. 46 CFR 169.253 - Miscellaneous systems and equipment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Miscellaneous systems and equipment. 169.253 Section 169.253 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Inspections § 169.253 Miscellaneous systems and equipment. (a) At...

  14. 46 CFR 169.253 - Miscellaneous systems and equipment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Miscellaneous systems and equipment. 169.253 Section 169.253 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Inspections § 169.253 Miscellaneous systems and equipment. (a) At...

  15. 6 CFR 25.3 - Delegation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Delegation. 25.3 Section 25.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY REGULATIONS TO SUPPORT ANTI-TERRORISM BY FOSTERING EFFECTIVE TECHNOLOGIES § 25.3 Delegation. All of the Secretary's responsibilities, powers, and functions...

  16. 50 CFR 253.18 - Program operating guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Program operating guidelines. 253.18 Section 253.18 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... Guarantee Program § 253.18 Program operating guidelines. The Division may issue Program operating guidelines...

  17. 28 CFR 25.3 - System information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

  18. 28 CFR 25.3 - System information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

  19. 28 CFR 25.3 - System information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

  20. 28 CFR 25.3 - System information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

  1. 36 CFR 25.3 - Supervision; suspensions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Supervision; suspensions. 25.3 Section 25.3 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL MILITARY PARKS; LICENSED GUIDE SERVICE REGULATIONS § 25.3 Supervision; suspensions. (a) The guide...

  2. 36 CFR 25.3 - Supervision; suspensions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Supervision; suspensions. 25.3 Section 25.3 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL MILITARY PARKS; LICENSED GUIDE SERVICE REGULATIONS § 25.3 Supervision; suspensions. (a) The guide...

  3. 36 CFR 25.3 - Supervision; suspensions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Supervision; suspensions. 25.3 Section 25.3 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL MILITARY PARKS; LICENSED GUIDE SERVICE REGULATIONS § 25.3 Supervision; suspensions. (a) The guide...

  4. 36 CFR 25.3 - Supervision; suspensions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Supervision; suspensions. 25.3 Section 25.3 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL MILITARY PARKS; LICENSED GUIDE SERVICE REGULATIONS § 25.3 Supervision; suspensions. (a) The guide...

  5. 36 CFR 25.3 - Supervision; suspensions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Supervision; suspensions. 25.3 Section 25.3 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL MILITARY PARKS; LICENSED GUIDE SERVICE REGULATIONS § 25.3 Supervision; suspensions. (a) The guide...

  6. 28 CFR 25.3 - System information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

  7. 30 CFR 253.11 - Who must demonstrate OSFR?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who must demonstrate OSFR? 253.11 Section 253.11 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 253.11 Who must...

  8. Critical Problems in Very Large Scale Computer Systems

    DTIC Science & Technology

    1989-03-31

    253-6043 Srinivas Devadas (617) 253-0454 Thomas F. Knight, Jr. (617) 253-7807 F. Thomson Leighton (617) 253-3662 Charles E. Leiserson (617) 253-5833...VLSI Memo No. 88-477, October 1988. S. Devadas , "General Decomposition of Sequential Machines: Relationships to State Assignment," to appear in...Perspective, C. Hewitt and G. Agha editors, MIT Press, 1989. Also MIT VLSI Memo No. 88-491, December 1988. * T. Leighton, B . Maggs, and S. Rao, "Universal

  9. 38 CFR 3.253-3.255 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false [Reserved] 3.253-3.255 Section 3.253-3.255 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate §§ 3.253-3...

  10. 38 CFR 3.253-3.255 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false [Reserved] 3.253-3.255 Section 3.253-3.255 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate §§ 3.253-3...

  11. 38 CFR 3.253-3.255 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false [Reserved] 3.253-3.255 Section 3.253-3.255 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate §§ 3.253-3...

  12. 38 CFR 3.253-3.255 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false [Reserved] 3.253-3.255 Section 3.253-3.255 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate §§ 3.253-3...

  13. 38 CFR 3.253-3.255 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false [Reserved] 3.253-3.255 Section 3.253-3.255 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Dependency, Income and Estate §§ 3.253-3...

  14. 27 CFR 25.3 - Forms prescribed.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Forms prescribed. 25.3 Section 25.3 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Scope of Regulations § 25.3 Forms prescribed. (a) The appropriate TTB...

  15. 27 CFR 25.3 - Forms prescribed.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Forms prescribed. 25.3 Section 25.3 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Scope of Regulations § 25.3 Forms prescribed. (a) The appropriate TTB...

  16. 27 CFR 25.3 - Forms prescribed.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Forms prescribed. 25.3 Section 25.3 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Scope of Regulations § 25.3 Forms prescribed. (a) The appropriate TTB...

  17. 27 CFR 25.3 - Forms prescribed.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Forms prescribed. 25.3 Section 25.3 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Scope of Regulations § 25.3 Forms prescribed. (a) The appropriate TTB...

  18. 7 CFR 953.253 - Assessment rate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 953.253 Section 953.253 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... STATES Assessment Rates § 953.253 Assessment rate. On and after June 1, 1998, an assessment rate of $0.01...

  19. 7 CFR 953.253 - Assessment rate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Assessment rate. 953.253 Section 953.253 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... STATES Assessment Rates § 953.253 Assessment rate. On and after June 1, 1998, an assessment rate of $0.01...

  20. 7 CFR 953.253 - Assessment rate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Assessment rate. 953.253 Section 953.253 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... STATES Assessment Rates § 953.253 Assessment rate. On and after June 1, 1998, an assessment rate of $0.01...

  1. 7 CFR 953.253 - Assessment rate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 953.253 Section 953.253 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... STATES Assessment Rates § 953.253 Assessment rate. On and after June 1, 1998, an assessment rate of $0.01...

  2. 7 CFR 983.253 - Assessment rate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 983.253 Section 983.253 Agriculture..., ARIZONA, AND NEW MEXICO Assessment Rate § 983.253 Assessment rate. (a) On and after September 1, 2006, a continuing assessment rate of $0.0007 per pound of assessed-weight pistachios is established for pistachios...

  3. 7 CFR 953.253 - Assessment rate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Assessment rate. 953.253 Section 953.253 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... STATES Assessment Rates § 953.253 Assessment rate. On and after June 1, 1998, an assessment rate of $0.01...

  4. 43 CFR 2.53 - Government contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Government contracts. 2.53 Section 2.53 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.53 Government contracts. (a) Required contract provisions. When a contract...

  5. 43 CFR 2.53 - Government contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Government contracts. 2.53 Section 2.53 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.53 Government contracts. (a) Required contract provisions. When a contract...

  6. 43 CFR 2.53 - Government contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Government contracts. 2.53 Section 2.53 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.53 Government contracts. (a) Required contract provisions. When a contract...

  7. 9 CFR 2.53 - Use of tags.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Use of tags. 2.53 Section 2.53 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.53 Use of tags. Official tags obtained by a dealer...

  8. 42 CFR 2.53 - Audit and evaluation activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Audit and evaluation activities. 2.53 Section 2.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.53 Audit and...

  9. 42 CFR 2.53 - Audit and evaluation activities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Audit and evaluation activities. 2.53 Section 2.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.53 Audit and...

  10. 42 CFR 2.53 - Audit and evaluation activities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Audit and evaluation activities. 2.53 Section 2.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.53 Audit and...

  11. 42 CFR 2.53 - Audit and evaluation activities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Audit and evaluation activities. 2.53 Section 2.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.53 Audit and...

  12. 42 CFR 2.53 - Audit and evaluation activities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Audit and evaluation activities. 2.53 Section 2.53 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CONFIDENTIALITY OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.53 Audit and...

  13. 9 CFR 2.53 - Use of tags.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Use of tags. 2.53 Section 2.53 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.53 Use of tags. Official tags obtained by a dealer...

  14. 9 CFR 2.53 - Use of tags.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Use of tags. 2.53 Section 2.53 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.53 Use of tags. Official tags obtained by a dealer...

  15. 9 CFR 2.53 - Use of tags.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Use of tags. 2.53 Section 2.53 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.53 Use of tags. Official tags obtained by a dealer...

  16. 9 CFR 2.53 - Use of tags.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Use of tags. 2.53 Section 2.53 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Identification of Animals § 2.53 Use of tags. Official tags obtained by a dealer...

  17. 27 CFR 25.3 - Forms prescribed.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Forms prescribed. 25.3 Section 25.3 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Scope of Regulations § 25.3 Forms prescribed. (a) The appropriate TTB...

  18. 30 CFR 253.15 - What are my general OSFR compliance responsibilities?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are my general OSFR compliance responsibilities? 253.15 Section 253.15 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 253...

  19. 30 CFR 253.32 - Are there alternative methods to demonstrate OSFR?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Are there alternative methods to demonstrate OSFR? 253.32 Section 253.32 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for Demonstrating OSFR § 253.32...

  20. Critical Problems in Very Large Scale Computer Systems

    DTIC Science & Technology

    1988-09-30

    253-6043 Srinivas Devadas (617) 253-0454 Thomas F. Knight, Jr. (617) 253-7807 F. Thomson Leighton (617) 253-3662 Charles E. Leiserson (617) 253-5833...J. Keen, P. Nuth, J. Larivee, and B . Totty, "Message-Driven Processor Architecture," MIT VLSI Memo No. 88-468, August 1988. *W. J. Dally and A. A...losses and gains) which are the first polynomial-time combinatorial algorithms for this problem. One algorithm runs in O(n2m2 lg 2 n Ig B ) time and the

  1. 44 CFR 206.253 - Insurance requirements for facilities damaged by disasters other than flood.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... facilities damaged by disasters other than flood. 206.253 Section 206.253 Emergency Management and Assistance... ASSISTANCE Public Assistance Insurance Requirements § 206.253 Insurance requirements for facilities damaged... facility and its contents which were damaged by a disaster other than flood, the Grantee shall notify the...

  2. 7 CFR 983.253 - Assessment rate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Assessment rate. 983.253 Section 983.253 Agriculture..., ARIZONA, AND NEW MEXICO Assessment Rate § 983.253 Assessment rate. (a) On and after September 1, 2011, an assessment rate of $0.0005 per pound is established for California, Arizona, and New Mexico pistachios. (b...

  3. 7 CFR 983.253 - Assessment rate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Assessment rate. 983.253 Section 983.253 Agriculture..., ARIZONA, AND NEW MEXICO Assessment Rate § 983.253 Assessment rate. (a) On and after September 1, 2011, an assessment rate of $0.0005 per pound is established for California, Arizona, and New Mexico pistachios. (b...

  4. 7 CFR 983.253 - Assessment rate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Assessment rate. 983.253 Section 983.253 Agriculture..., ARIZONA, AND NEW MEXICO Assessment Rate § 983.253 Assessment rate. (a) On and after September 1, 2011, an assessment rate of $0.0005 per pound is established for California, Arizona, and New Mexico pistachios. (b...

  5. 48 CFR 253.208-1 - DD Form 448, Military Interdepartmental Purchase Request.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 448, Military Interdepartmental Purchase Request. 253.208-1 Section 253.208-1 Federal Acquisition Regulations System DEFENSE... DD Form 448, Military Interdepartmental Purchase Request. Follow the procedures at PGI 253.208-1 for...

  6. 30 CFR 253.51 - What are the penalties for not complying with this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the penalties for not complying with this part? 253.51 Section 253.51 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Revocation and Penalties § 253...

  7. 30 CFR 253.42 - How can I amend my list of COFs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How can I amend my list of COFs? 253.42 Section 253.42 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information § 253.42 How...

  8. 30 CFR 253.20 - What methods may I use to demonstrate OSFR?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What methods may I use to demonstrate OSFR? 253.20 Section 253.20 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for Demonstrating OSFR § 253.20...

  9. 30 CFR 253.50 - How can MMS refuse or invalidate my OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How can MMS refuse or invalidate my OSFR evidence? 253.50 Section 253.50 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Revocation and Penalties § 253.50 How...

  10. 30 CFR 253.30 - How can I use an indemnity as OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How can I use an indemnity as OSFR evidence? 253.30 Section 253.30 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for Demonstrating OSFR § 253.30...

  11. 30 CFR 253.60 - To whom may I present a claim?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false To whom may I present a claim? 253.60 Section 253.60 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Claims for Oil-Spill Removal Costs and Damages § 253.60 To...

  12. 30 CFR 253.21 - How can I use self-insurance as OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How can I use self-insurance as OSFR evidence? 253.21 Section 253.21 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for Demonstrating OSFR § 253.21...

  13. 30 CFR 253.41 - What terms must I include in my OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What terms must I include in my OSFR evidence? 253.41 Section 253.41 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information § 253.41 What terms must I include in my...

  14. 37 CFR 253.8 - Terms and rates of royalty payments for the use of published pictorial, graphic, and sculptural...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... payments for the use of published pictorial, graphic, and sculptural works. 253.8 Section 253.8 Patents... BROADCASTING § 253.8 Terms and rates of royalty payments for the use of published pictorial, graphic, and sculptural works. (a) Scope. This section establishes rates and terms for the use of published pictorial...

  15. MOF-253-Pd(OAc) 2 : a recyclable MOF for transition-metal catalysis in water

    DOE PAGES

    Van Zeeland, Ryan; Li, Xinle; Huang, Wenyu; ...

    2016-06-06

    We report palladium(II)-functionalized MOF-253 (MOF-253-Pd(OAc) 2) as a recyclable catalyst to form all-carbon quaternary centers via conjugate additions of arylboronic acids to β,β-disubstituted enones in aqueous media. We demonstrate MOF-253-Pd(OAc) 2 can be reused 8 times to form ketone products in yields above 75% while maintaining its crystallinity. Additions of a range of stereoelectronically diverse arylboronic acids to a variety of β,β-disubstituted enones catalyzed by MOF-253-Pd(OAc) 2 occur in modest-to-high yields (34–95%).

  16. 78 FR 43888 - Compliance Policy Guide Sec. 253.100-Use of Units of Plasma and Fresh Frozen Plasma Which Have...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ...] Compliance Policy Guide Sec. 253.100--Use of Units of Plasma and Fresh Frozen Plasma Which Have Been Thawed... guide (CPG) entitled ``Sec. 253.100--Use of Units of Plasma and Fresh Frozen Plasma Which Have Been... ``Sec. 253.100-- Use of Units of Plasma and Fresh Frozen Plasma Which Have Been Thawed'' on October 1...

  17. 40 CFR 408.253 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 408.253 Section 408.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Pacific Coast Hand-Shucked Oyster...

  18. Critical Problems in Very Large Scale Computer Systems

    DTIC Science & Technology

    1990-03-31

    Srinivas Devadas (617) 253-0454 Thomas F. Knight, Jr. (617) 253-7807 F. Thomson Leighton (617) 253-3662 Charles E. Leiserson (617) 253-5833 Jacob K...Aided Design of Integrated Circuits and Systems, pages 19-29, January 1990. [5] S. Arora, T. Leighton, and B . Maggs. On-line algorithms for path...selection in a non-blocking network. In Proceedings of the 21st Annual ACM Symposium on Theory of Computing, May 1990. To appear. [6] P. Ashar, S. Devadas

  19. 40 CFR 61.253 - Determining compliance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Determining compliance. 61.253 Section 61.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standards for Radon Emissions...

  20. 1α,25(OH)2D3 differentially regulates miRNA expression in human bladder cancer cells

    PubMed Central

    Ma, Yingyu; Hu, Qiang; Luo, Wei; Pratt, Rachel N.; Glenn, Sean T.; Liu, Song; Trump, Donald L.; Johnson, Candace S.

    2014-01-01

    Bladder cancer is the fourth most commonly diagnosed cancer in men and eighth leading cause of cancer-related death in the US. Epidemiological and experimental studies strongly suggest a role for 1α,25(OH)2D3 in cancer prevention and treatment. The antitumor activities of 1α,25(OH)2D3 are mediated by the induction of cell cycle arrest, apoptosis, differentiation and the inhibition of angiogenesis and metastasis. MiRNAs play important regulatory roles in cancer development and progression. However, the role of 1α,25(OH)2D3 in the regulation of miRNA expression and the potential impact in bladder cancer has not been investigated. Therefore, we studied 1α,25(OH)2D3-regulated miRNA expression profiles in human bladder cancer cell line 253J and the highly tumorigenic and metastatic derivative line 253J-BV by miRNA qPCR panels. 253 J and 253J-BV cells express endogenous vitamin D receptor (VDR) which can be further induced by 1α,25(OH)2D3. VDR target gene 24-hydroxylase was induced by 1α,25(OH)2D3 in both cell lines, indicating functional 1α,25(OH)2D3 signaling. The miRNA qPCR panel assay results showed that 253J and 253J-BV cells have distinct miRNA expression profiles. Further, 1α,25(OH)2D3 differentially regulated miRNA expression profiles in 253J and 253 J-BV cells in a dynamic manner. Pathway analysis of the miRNA target genes revealed distinct patterns of contribution to the molecular functions and biological processes in the two cell lines. In conclusion, 1α,25(OH)2D3 differentially regulates the expression of miRNAs, which may contribute to distinct biological functions, in human bladder 253J and 253J-BV cells. PMID:25263658

  1. 50 CFR 253.15 - Recourse against parties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Recourse against parties. 253.15 Section 253.15 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program...

  2. 50 CFR 253.15 - Recourse against parties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Recourse against parties. 253.15 Section 253.15 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program...

  3. 50 CFR 253.15 - Recourse against parties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Recourse against parties. 253.15 Section 253.15 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program...

  4. 50 CFR 253.15 - Recourse against parties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Recourse against parties. 253.15 Section 253.15 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE AID TO FISHERIES FISHERIES ASSISTANCE PROGRAMS Fisheries Finance Program...

  5. 7 CFR 1220.253 - Personal liability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Personal liability. 1220.253 Section 1220.253 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... responsible, either individually or jointly, in any way whatsoever, to any person for errors in judgment...

  6. 47 CFR 24.253 - Termination of cost-sharing obligations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Termination of cost-sharing obligations. 24.253 Section 24.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990...

  7. 47 CFR 24.253 - Termination of cost-sharing obligations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Termination of cost-sharing obligations. 24.253 Section 24.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990...

  8. 47 CFR 24.253 - Termination of cost-sharing obligations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Termination of cost-sharing obligations. 24.253 Section 24.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990...

  9. 47 CFR 24.253 - Termination of cost-sharing obligations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Termination of cost-sharing obligations. 24.253 Section 24.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Broadband PCS Policies Governing Microwave Relocation from the 1850-1990...

  10. Metal-organic-framework-derived carbons: Applications as solid-base catalyst and support for Pd nanoparticles in tandem catalysis

    DOE PAGES

    Li, Xinle; Zhang, Biying; Fang, Yuhui; ...

    2017-02-11

    Here, the facile pyrolysis of a bipyridyl metal-organic framework, MOF-253, produces N-doped porous carbons (Cz-MOF-253), which exhibit excellent catalytic activity in the Knoevenagel condensation reaction and outperform other nitrogen-containing MOF-derived carbons. More importantly, by virtue of their high Lewis basicity and porous nature, Cz-MOF-253-supported Pd nanoparticles (Pd/Cz-MOF-253-800) show excellent performance in a one-pot sequential Knoevenagel condensation-hydrogenation reaction.

  11. Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket And Transcription Activation Through Tyrosine Expulsion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Newberry, K.J.; Huffman, J.L.; Miller, M.C.

    2009-05-22

    BmrR is a member of the MerR family and a multidrug binding transcription factor that up-regulates the expression of the bmr multidrug efflux transporter gene in response to myriad lipophilic cationic compounds. The structural mechanism by which BmrR binds these chemically and structurally different drugs and subsequently activates transcription is poorly understood. Here, we describe the crystal structures of BmrR bound to rhodamine 6G (R6G) or berberine (Ber) and cognate DNA. These structures reveal each drug stacks against multiple aromatic residues with their positive charges most proximal to the carboxylate group of Glu-253 and that, unlike other multidrug binding pockets,more » that of BmrR is rigid. Substitution of Glu-253 with either alanine (E253A) or glutamine (E253Q) results in unpredictable binding affinities for R6G, Ber, and tetraphenylphosphonium. Moreover, these drug binding studies reveal that the negative charge of Glu-253 is not important for high affinity binding to Ber and tetraphenylphosphonium but plays a more significant, but unpredictable, role in R6G binding. In vitro transcription data show that E253A and E253Q are constitutively active, and structures of the drug-free E253A-DNA and E253Q-DNA complexes support a transcription activation mechanism requiring the expulsion of Tyr-152 from the multidrug binding pocket. In sum, these data delineate the mechanism by which BmrR binds lipophilic, monovalent cationic compounds and suggest the importance of the redundant negative electrostatic nature of this rigid drug binding pocket that can be used to discriminate against molecules that are not substrates of the Bmr multidrug efflux pump.« less

  12. 7 CFR 253.3 - Availability of commodities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Availability of commodities. 253.3 Section 253.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... opportunity to obtain a more nutritious diet and shall represent an acceptable nutritional alternative to Food...

  13. 7 CFR 253.3 - Availability of commodities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Availability of commodities. 253.3 Section 253.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... opportunity to obtain a more nutritious diet and shall represent an acceptable nutritional alternative to Food...

  14. 7 CFR 253.3 - Availability of commodities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Availability of commodities. 253.3 Section 253.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... opportunity to obtain a more nutritious diet and shall represent an acceptable nutritional alternative to Food...

  15. 7 CFR 253.3 - Availability of commodities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Availability of commodities. 253.3 Section 253.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... opportunity to obtain a more nutritious diet and shall represent an acceptable nutritional alternative to Food...

  16. 7 CFR 253.3 - Availability of commodities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Availability of commodities. 253.3 Section 253.3 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... opportunity to obtain a more nutritious diet and shall represent an acceptable nutritional alternative to Food...

  17. 50 CFR 253.14 - Economic and financial requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Economic and financial requirements. 253... Obligation Guarantee Program § 253.14 Economic and financial requirements. (a) Income and expense projections... project's economic, technical, or financial feasibility. The Division will select and employ the necessary...

  18. 40 CFR 25.3 - Policy and objectives.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Policy and objectives. 25.3 Section 25.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC PARTICIPATION IN PROGRAMS UNDER THE RESOURCE CONSERVATION AND RECOVERY ACT, THE SAFE DRINKING WATER ACT, AND THE CLEAN WATER ACT...

  19. 14 CFR 21.253 - Type certificates: application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... made; (4) After placing the required technical data and type inspection report in the technical data... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Type certificates: application. 21.253....253 Type certificates: application. Link to an amendment published at 74 FR 53390, October 16, 2009...

  20. 37 CFR 253.11 - Notice of restrictions on use of reproductions of transmission programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of reproductions of transmission programs. 253.11 Section 253.11 Patents, Trademarks, and Copyrights... restrictions on use of reproductions of transmission programs. Any public broadcasting entity which, pursuant to 17 U.S.C. 118, supplies a reproduction of a transmission program to governmental bodies or...

  1. 37 CFR 253.11 - Notice of restrictions on use of reproductions of transmission programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of reproductions of transmission programs. 253.11 Section 253.11 Patents, Trademarks, and Copyrights... restrictions on use of reproductions of transmission programs. Any public broadcasting entity which, pursuant to 17 U.S.C. 118, supplies a reproduction of a transmission program to governmental bodies or...

  2. 49 CFR 234.253 - Flashing light units and lamp voltage.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Flashing light units and lamp voltage. 234.253....253 Flashing light units and lamp voltage. (a) Each flashing light unit shall be inspected when... with installation specifications. (b) Lamp voltage shall be tested when installed and at least once...

  3. 49 CFR 234.253 - Flashing light units and lamp voltage.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Flashing light units and lamp voltage. 234.253....253 Flashing light units and lamp voltage. (a) Each flashing light unit shall be inspected when... with installation specifications. (b) Lamp voltage shall be tested when installed and at least once...

  4. 49 CFR 234.253 - Flashing light units and lamp voltage.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Flashing light units and lamp voltage. 234.253... Maintenance, Inspection, and Testing Inspections and Tests § 234.253 Flashing light units and lamp voltage. (a... proper alignment and frequency of flashes in accordance with installation specifications. (b) Lamp...

  5. 49 CFR 234.253 - Flashing light units and lamp voltage.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Flashing light units and lamp voltage. 234.253... Maintenance, Inspection, and Testing Inspections and Tests § 234.253 Flashing light units and lamp voltage. (a... proper alignment and frequency of flashes in accordance with installation specifications. (b) Lamp...

  6. 49 CFR 234.253 - Flashing light units and lamp voltage.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Flashing light units and lamp voltage. 234.253....253 Flashing light units and lamp voltage. (a) Each flashing light unit shall be inspected when... with installation specifications. (b) Lamp voltage shall be tested when installed and at least once...

  7. 50 CFR 14.253 - What are the restrictions contained in these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false What are the restrictions contained in these regulations? 14.253 Section 14.253 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... IMPORTATION OF WILDLIFE AND PLANTS IMPORTATION, EXPORTATION, AND TRANSPORTATION OF WILDLIFE Captive Wildlife...

  8. 37 CFR 253.5 - Performance of musical compositions by public broadcasting entities licensed to colleges and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... compositions by public broadcasting entities licensed to colleges and universities. 253.5 Section 253.5 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES... and universities. (a) Scope. This section applies to the performance of copyrighted published...

  9. 30 CFR 250.253 - What lease stipulations information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What lease stipulations information must accompany the DPP or DOCD? 250.253 Section 250.253 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Information Contents of Development and Production Plans (dpp) and Development Operations Coordination...

  10. 50 CFR 253.16 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fees. 253.16 Section 253.16 Wildlife and... Fees. (a) Application fee. The Division will not accept an application without the application fee. Fifty percent of the application fee is fully earned at application acceptance, and is not refundable...

  11. 50 CFR 253.22 - State projects.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false State projects. 253.22 Section 253.22... State projects. (a) General—(1) Designation of state agency. The Governor of each state shall notify the... participation under the Act, to sign project documents, and to receive payments. (2) States that choose to...

  12. 14 CFR 23.253 - High speed characteristics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false High speed characteristics. 23.253 Section... Requirements § 23.253 High speed characteristics. If a maximum operating speed VMO/MMO is established under § 23.1505(c), the following speed increase and recovery characteristics must be met: (a) Operating...

  13. 14 CFR 23.253 - High speed characteristics.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false High speed characteristics. 23.253 Section... Requirements § 23.253 High speed characteristics. If a maximum operating speed VMO/MMO is established under § 23.1505(c), the following speed increase and recovery characteristics must be met: (a) Operating...

  14. 50 CFR 253.52 - State projects.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false State projects. 253.52 Section 253.52... State projects. (a) General—(1) Designation of state agency. The Governor of each state shall notify the... participation under the Act, to sign project documents, and to receive payments. (2) States that choose to...

  15. 50 CFR 253.52 - State projects.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false State projects. 253.52 Section 253.52... State projects. (a) General—(1) Designation of state agency. The Governor of each state shall notify the... participation under the Act, to sign project documents, and to receive payments. (2) States that choose to...

  16. 50 CFR 253.52 - State projects.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false State projects. 253.52 Section 253.52... State projects. (a) General—(1) Designation of state agency. The Governor of each state shall notify the... participation under the Act, to sign project documents, and to receive payments. (2) States that choose to...

  17. 50 CFR 253.52 - State projects.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false State projects. 253.52 Section 253.52... State projects. (a) General—(1) Designation of state agency. The Governor of each state shall notify the... participation under the Act, to sign project documents, and to receive payments. (2) States that choose to...

  18. 30 CFR 253.40 - What OSFR evidence must I submit to MMS?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What OSFR evidence must I submit to MMS? 253.40 Section 253.40 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information...

  19. 30 CFR 253.32 - Are there alternative methods to demonstrate OSFR?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Are there alternative methods to demonstrate OSFR? 253.32 Section 253.32 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES...

  20. Observation of the Starburst Galaxy NGC 253 with the OSSE Instrument

    DTIC Science & Technology

    1993-01-01

    produced by a very recent Type Ia or Ib supernova outburst in NGC 253. INTRODUCTION NGC 253 is the third brightest infrared galaxy with a luminosity of ~ 4...1010 L.O1 in the far infrared band. This nearby (~ 3 Mpc) spiral Sc galaxy is undergoing extensive star formation within its central few kilo...100 MeV Ginga extrapolation Ginga data OSSE result Model WW2 Day 20 Model WR6C Day 120 Fig. 1 – The derived photon fluxes for NGC 253. The Ginga X-ray

  1. 1α,25(OH)2D3 differentially regulates miRNA expression in human bladder cancer cells.

    PubMed

    Ma, Yingyu; Hu, Qiang; Luo, Wei; Pratt, Rachel N; Glenn, Sean T; Liu, Song; Trump, Donald L; Johnson, Candace S

    2015-04-01

    Bladder cancer is the fourth most commonly diagnosed cancer in men and eighth leading cause of cancer-related death in the US. Epidemiological and experimental studies strongly suggest a role for 1α,25(OH)2D3 in cancer prevention and treatment. The antitumor activities of 1α,25(OH)2D3 are mediated by the induction of cell cycle arrest, apoptosis, differentiation and the inhibition of angiogenesis and metastasis. miRNAs play important regulatory roles in cancer development and progression. However, the role of 1α,25(OH)2D3 in the regulation of miRNA expression and the potential impact in bladder cancer has not been investigated. Therefore, we studied 1α,25(OH)2D3-regulated miRNA expression profiles in human bladder cancer cell line 253J and the highly tumorigenic and metastatic derivative line 253J-BV by miRNA qPCR panels. 253J and 253J-BV cells express endogenous vitamin D receptor (VDR), which can be further induced by 1α,25(OH)2D3. VDR target gene 24-hydroxylase was induced by 1α,25(OH)2D3 in both cell lines, indicating functional 1α,25(OH)2D3 signaling. The miRNA qPCR panel assay results showed that 253J and 253J-BV cells have distinct miRNA expression profiles. Further, 1α,25(OH)2D3 differentially regulated miRNA expression profiles in 253J and 253J-BV cells in a dynamic manner. Pathway analysis of the miRNA target genes revealed distinct patterns of contribution to the molecular functions and biological processes in the two cell lines. In conclusion, 1α,25(OH)2D3 differentially regulates the expression of miRNAs, which may contribute to distinct biological functions, in human bladder 253J and 253J-BV cells. This article is part of a Special Issue entitled '17th Vitamin D Workshop'. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells.

    PubMed

    Song, Jing; Li, Yue

    2017-01-01

    Acquisition of epithelial-mesenchymal transition (EMT) has recently been proposed as an important contributor of drug resistance in cervical cancer cells. However, the underlying mechanisms are still unclear. MicroRNAs play a crucial role in regulating EMT. The aim of this study was to explore the potential role of miR-25-3p in regulating EMT in cisplatin-resistant (CR) cervical cancer cells. To this end, we established stable CR cervical cancer cells, HeLa-CR and CaSki-CR, and investigated the function of miR-25-3p in regulating EMT. It is found that CR cervical cancer cells possessed more EMT characteristics and demonstrated higher migratory abilities and invasiveness. miR-25-3p downregulation was also seen in HeLa-CR and CaSki-CR cells. Of note, ectopic expression of miR-25-3p reversed the EMT phenotype and sensitized CR cells to cisplatin via targeting Sema4C. Furthermore, stable overexpression of miR-25-3p in HeLa-CR cells suppressed tumor growth in mice, downregulated Sema4C and Snail, and upregulated E-cadherin compared with the control group. These results suggest that miR-25-3p is an important regulator of cervical cancer EMT and chemoresistance. Thus, upregulation of miR-25-3p could be a novel approach to treat cervical cancers that are resistant to chemotherapy. © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  3. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Becker, Stephen Allan

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowsharemore » Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.« less

  4. 48 CFR 253.215-70 - DD Form 1547, Record of Weighted Guidelines Application.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1547, Record of... Forms 253.215-70 DD Form 1547, Record of Weighted Guidelines Application. Follow the procedures at PGI 253.215-70 for completing DD Form 1547. [71 FR 69495, Dec. 1, 2006] ...

  5. 30 CFR 253.3 - How are the terms used in this regulation defined?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... United States, the District of Columbia, the Commonwealth of Puerto Rico, Guam, American Samoa, the... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How are the terms used in this regulation defined? 253.3 Section 253.3 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND...

  6. 37 CFR 2.53 - Requirements for drawings filed through the TEAS.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... filed through the TEAS. 2.53 Section 2.53 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND... for drawings filed through the TEAS. The drawing must meet the requirements of § 2.52. In addition, in a TEAS submission, the drawing must meet the following requirements: (a) Standard character drawings...

  7. 30 CFR 250.253 - What lease stipulations information must accompany the DPP or DOCD?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What lease stipulations information must accompany the DPP or DOCD? 250.253 Section 250.253 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... OUTER CONTINENTAL SHELF Plans and Information Contents of Development and Production Plans (dpp) and...

  8. 30 CFR 253.51 - What are the penalties for not complying with this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What are the penalties for not complying with this part? 253.51 Section 253.51 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES...

  9. 30 CFR 253.20 - What methods may I use to demonstrate OSFR?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What methods may I use to demonstrate OSFR? 253.20 Section 253.20 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for...

  10. 30 CFR 253.1 - What is the purpose of this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is the purpose of this part? 253.1 Section 253.1 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL... the Oil Pollution Act of 1990 (OPA), as amended, 33 U.S.C. 2701 et seq. ...

  11. 30 CFR 253.23 - What information must I submit to support my net worth demonstration?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What information must I submit to support my net worth demonstration? 253.23 Section 253.23 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for...

  12. 30 CFR 253.60 - To whom may I present a claim?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false To whom may I present a claim? 253.60 Section 253.60 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Claims for Oil-Spill...

  13. 30 CFR 253.50 - How can MMS refuse or invalidate my OSFR evidence?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How can MMS refuse or invalidate my OSFR evidence? 253.50 Section 253.50 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES...

  14. 30 CFR 253.23 - What information must I submit to support my net worth demonstration?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What information must I submit to support my net worth demonstration? 253.23 Section 253.23 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR...

  15. 30 CFR 253.43 - When is my OSFR demonstration or the amendment to my OSFR demonstration effective?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When is my OSFR demonstration or the amendment to my OSFR demonstration effective? 253.43 Section 253.43 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES...

  16. 30 CFR 253.21 - How can I use self-insurance as OSFR evidence?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How can I use self-insurance as OSFR evidence? 253.21 Section 253.21 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for...

  17. 30 CFR 253.29 - How can I use insurance as OSFR evidence?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How can I use insurance as OSFR evidence? 253.29 Section 253.29 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for...

  18. 30 CFR 253.30 - How can I use an indemnity as OSFR evidence?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How can I use an indemnity as OSFR evidence? 253.30 Section 253.30 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for...

  19. Improvement thermostability of Pseudoalteromonas carrageenovora arylsulfatase by rational design.

    PubMed

    Zhu, Yanbing; Qiao, Chaochao; Li, Hebin; Li, Lijun; Xiao, Anfeng; Ni, Hui; Jiang, Zedong

    2018-03-01

    This study aimed to improve the thermostability of arylsulfatase from Pseudoalteromonas carrageenovora. A total of 10 single-site mutants were chosen using the PoPMuSiC program, and two mutants of K253N and P314T showed enhanced thermal stability. By saturation mutagenesis and thermostability analysis, K253H and P314T were the best mutants at the two sites. Combinational mutations of K253H, P314T and H260L were subsequently introduced, and the best mutant of K253H/H260L was selected. Thermal inactivation analysis showed the half-life (t 1/2 ) value at 55°C for K253H/H260L was 7.7-fold that of the wild-type enzyme (WT), meanwhile this mutant maintained the specific enzyme activity. Structure modeling demonstrated that the additional hydrogen bonds, optimization of surface charge-charge interactions, and increasing of hydrophobic interaction could account for the improved thermostability imparted by K253H/H260L. Copyright © 2017. Published by Elsevier B.V.

  20. Molecular basis of unusually high neutralization resistance in tier 3 HIV-1 strain 253-11.

    PubMed

    Moyo, Thandeka; Ereño-Orbea, June; Jacob, Rajesh Abraham; Pavillet, Clara E; Kariuki, Samuel Mundia; Tangie, Emily N; Julien, Jean-Philippe; Dorfman, Jeffrey R

    2018-04-04

    Understanding the mechanisms used by HIV-1 to evade antibody neutralization may contribute to the design of a high-coverage vaccine. The tier 3 virus 253-11, is poorly neutralized by subtype-matched and subtype C sera, even when compared to other tier 3 viruses, and is also recognized poorly by V3/glycan targeting monoclonal antibodies. We found that sequence polymorphism in the V3 loop and N-linked glycosylation sites only minimally contribute to the high neutralization resistance of 253-11. Interestingly, the 253-11 membrane proximal external region (MPER) is rarely recognized by sera in the context of the wild-type virus, but is commonly recognized in the context of an HIV-2 chimeric virus, suggesting steric or kinetic hindrance of binding to MPER in the native Env. Mutations in the 253-11 MPER - which were previously reported to increase the lifetime of the pre-fusion Envelope (Env) conformation - affected the resistance of 253-11 to antibodies targeting various epitopes on HIV-1 Env, presumably destabilizing its otherwise stable, closed trimer structure. To gain insight into the structure of 253-11, we constructed and crystallized a recombinant 253-11 SOSIP trimer. The resulting structure revealed that the heptad repeat helices in gp41 are drawn in close proximity to the trimer axis and that gp120 protomers also showed a relatively compact disposition around the trimer axis. These observations give substantial insight into the molecular features of an envelope spike from a tier 3 virus and into possible mechanisms that may contribute to its unusually high neutralization resistance. IMPORTANCE HIV-1 isolates that are highly resistant to broadly neutralizing antibodies could limit the efficacy of an antibody-based vaccine. We studied 253-11, which is highly resistant to commonly-elicited neutralizing antibodies. To further understand its resistance, we made mutations that are known to delay fusion and thus increase the time the virus spends in the open conformation following CD4-binding. Interestingly, we found that these mutations affect the 253-11 Envelope (Env) spike before CD4 binding, presumably by destabilizing the trimer structure. To gain further information about the structure of the 253-11 Env trimer, we generated a recombinant 253-11 SOSIP trimer. The crystal structure of the SOSIP trimer revealed that the gp41 helices and the gp120 protomers were drawn in towards the center of the molecule compared to most solved HIV-1 Env structures. These observations provide insight into the distinct molecular features of a Tier 3 envelope spike. Copyright © 2018 American Society for Microbiology.

  1. 48 CFR 253.213-70 - Completion of DD Form 1155, Order for Supplies or Services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Completion of DD Form 1155... Forms 253.213-70 Completion of DD Form 1155, Order for Supplies or Services. Follow the procedures at PGI 253.213-70 for completion of DD Form 1155. [71 FR 3413, Jan. 23, 2006] ...

  2. 44 CFR 206.253 - Insurance requirements for facilities damaged by disasters other than flood.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... facilities damaged by disasters other than flood. 206.253 Section 206.253 Emergency Management and Assistance... by disasters other than flood. (a) Prior to approval of a Federal grant for the restoration of a facility and its contents which were damaged by a disaster other than flood, the Grantee shall notify the...

  3. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part to...

  4. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part to...

  5. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part to...

  6. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part to...

  7. 47 CFR 90.253 - Use of frequency 5167.5 kHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Use of frequency 5167.5 kHz. 90.253 Section 90.253 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES... frequency 5167.5 kHz. The frequency 5167.5 kHz may be used by any station authorized under this part to...

  8. 30 CFR 253.22 - How do I apply to use self-insurance as OSFR evidence?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How do I apply to use self-insurance as OSFR evidence? 253.22 Section 253.22 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES...

  9. 30 CFR 253.12 - May I ask MMS for a determination of whether I must demonstrate OSFR?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I ask MMS for a determination of whether I must demonstrate OSFR? 253.12 Section 253.12 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and...

  10. 30 CFR 253.31 - How can I use a surety bond as OSFR evidence?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How can I use a surety bond as OSFR evidence? 253.31 Section 253.31 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for...

  11. CS in nearby galaxies: Distribution, kinematics, and multilevel studies

    NASA Technical Reports Server (NTRS)

    Mauersberger, R.; Henkel, Christian

    1990-01-01

    As a result of observations at the Institute for Radio Astronomy in the Millimeter Range (IRAM) 30-m telescope, maps of the distribution of the J = 2-1 transition of CS toward the galaxies IC 342 and NGC 253 are presented. The distribution of the CS emission from NGC 253 is consistent with the CO 1-0 line. The distribution of the CS emission from IC 342, however, resembles more that seen in the CO 3-2 line. For the first time, the detection of the isotopic substitution C-34S is reported toward an external galaxy: The C-34S 2-1 line has been detected toward NGC 253 and M 82 and the C-34S line has been detected tentatively toward M 82. Also for the first time, extragalactic CS has been observed in the 3-2 (toward NGC 253, IC 342 and M 82) and 5-4 (NGC 253 and IC 342) transitions.

  12. Depletion of cdc-25.3, a Caenorhabditis elegans orthologue of cdc25, increases physiological germline apoptosis.

    PubMed

    Sung, Minhee; Kawasaki, Ichiro; Shim, Yhong-Hee

    2017-07-01

    In Caenorhabditis elegans hermaphrodites, physiological germline apoptosis is higher in cdc-25.3 mutants than in wild-type. The elevated germline apoptosis in cdc-25.3 mutants seems to be induced by accumulation of double-stranded DNA breaks (DSBs). Both DNA damage and synapsis checkpoint genes are required to increase the germline apoptosis. Notably, the number of germ cells that lose P-granule components, PGL-1 and PGL-3, increase in cdc-25.3 mutants, and the increase in germline apoptosis requires the activity of SIR-2.1, a Sirtuin orthologue. These results suggest that elevation of germline apoptosis in cdc-25.3 mutants is induced by accumulation of DSBs, leading to a loss of PGL-1 and PGL-3 in germ cells, which promotes cytoplasmic translocation of SIR-2.1, and finally activates the core apoptotic machinery. © 2017 Federation of European Biochemical Societies.

  13. 48 CFR 253.208-2 - DD Form 448-2, Acceptance of MIPR.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 448-2, Acceptance... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.208-2 DD Form 448-2, Acceptance of MIPR. Follow the procedures at PGI 253.208-2 for use of DD Form 448-2. [71 FR 39005...

  14. 30 CFR 253.22 - How do I apply to use self-insurance as OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I apply to use self-insurance as OSFR evidence? 253.22 Section 253.22 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... How do I apply to use self-insurance as OSFR evidence? (a) You must submit a complete Form MMS-1018...

  15. 40 CFR 147.253 - Existing Class I, II (except enhanced recovery and hydrocarbon storage) and III wells authorized...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Existing Class I, II (except enhanced recovery and hydrocarbon storage) and III wells authorized by rule. 147.253 Section 147.253 Protection of... recovery and hydrocarbon storage) and III wells authorized by rule. Maximum injection pressure. The owner...

  16. 40 CFR 147.253 - Existing Class I, II (except enhanced recovery and hydrocarbon storage) and III wells authorized...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Existing Class I, II (except enhanced recovery and hydrocarbon storage) and III wells authorized by rule. 147.253 Section 147.253 Protection of... recovery and hydrocarbon storage) and III wells authorized by rule. Maximum injection pressure. The owner...

  17. 30 CFR 253.28 - What financial test procedures must I use to evaluate the amount of self-insurance allowed as...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What financial test procedures must I use to evaluate the amount of self-insurance allowed as OSFR evidence based on unencumbered assets? 253.28 Section 253.28 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL...

  18. 30 CFR 253.25 - What financial test procedures must I use to determine the amount of self-insurance allowed as...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What financial test procedures must I use to determine the amount of self-insurance allowed as OSFR evidence based on net worth? 253.25 Section 253.25 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL...

  19. Format Guide for Scientific and Technical Reports.

    DTIC Science & Technology

    1984-01-01

    supported by the discussion. Graphkic Services The Graphic Services Section (Code 2632) provides a variety of layout and design services. Camera-ready artwork...complex typography , elaborate graphic elements, extensive computer printouts, and other unusual materials that explain the project. With few exceptions...2630 Publications Branch Office 222/253 72379 S Publications Control Center 222/253 73508 Editorial 222/253 72782 Graphic Services 222/234 72756 73989

  20. 48 CFR 253.213 - Simplified acquisition procedures (SF's 18, 30, 44, 1165, 1449, and OF's 336, 347, and 348).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Simplified acquisition procedures (SF's 18, 30, 44, 1165, 1449, and OF's 336, 347, and 348). 253.213 Section 253.213 Federal... OF's 336, 347, and 348). (f) DoD uses the DD Form 1155, Order for Supplies or Services, instead of OF...

  1. 75 FR 43082 - National Oil and Hazardous Substances Pollution Contingency Plan; National Priorities List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... pertains to the soil and groundwater of parcels 24, 27, 28, 2-53, 2-53L, 2-54, 2-54L, 2-70, 2-70L, 3-89, 3... Priorities List (NPL). This partial deletion pertains to the soil and groundwater of parcels 24, 27, 28, 2-53... 24 Phase I ROD, SEP 1998.. Soil & Groundwater. Phase III ROD, AUG 2003 Soil & Groundwater. 27, 2-27B...

  2. Regulation of the Incorporation of Tissue Factor into Microparticles by Serine Phosphorylation of the Cytoplasmic Domain of Tissue Factor*

    PubMed Central

    Collier, Mary E. W.; Ettelaie, Camille

    2011-01-01

    The mechanisms that regulate the incorporation and release of tissue factors (TFs) into cell-derived microparticles are as yet unidentified. In this study, we have explored the regulation of TF release into microparticles by the phosphorylation of serine residues within the cytoplasmic domain of TF. Wild-type and mutant forms of TF, containing alanine and aspartate substitutions at Ser253 and Ser258, were overexpressed in coronary artery and dermal microvascular endothelial cells and microparticle release stimulated with PAR2 agonist peptide (PAR2-AP). The release of TF antigen and activity was then monitored. In addition, the phosphorylation state of the two serine residues within the released microparticles and the cells was monitored for 150 min. The release of wild-type TF as procoagulant microparticles peaked at 90 min and declined thereafter in both cell types. The TF within these microparticles was phosphorylated at Ser253 but not at Ser258. Aspartate substitution of Ser253 resulted in rapid release of TF antigen but not activity, whereas TF release was reduced and delayed by alanine substitution of Ser253 or aspartate substitution of Ser258. Alanine substitution of Ser258 prolonged the release of TF following PAR2-AP activation. The release of TF was concurrent with phosphorylation of Ser253 and was followed by dephosphorylation at 120 min and phosphorylation of Ser258. We propose a sequential mechanism in which the phosphorylation of Ser253 through PAR2 activation results in the incorporation of TF into microparticles, simultaneously inducing Ser258 phosphorylation. Phosphorylation of Ser258 in turn promotes the dephosphorylation of Ser253 and suppresses the release of TF. PMID:21310953

  3. Summary of Federal Aviation Administration Responses to National Transportation Safety Board Safety Recommendations.

    DTIC Science & Technology

    1980-10-01

    strike A-80-45 Beech C-18S electrical 63 terminal studs A-80-46 Redcoat Air Cargo, Ltd., 69 Bristol Britannia 253 crash Billerica, Massachusetts...Ltd., Bristol Britannia 253, which crashed about 7 minutes after takeoff from Boston’s Logan International Airport on February 16, 1980. We...1980. This recommendation resulted from the Board’s investigation of a Redcoat Air Cargo, Ltd., Bristol Britannia 253 which crashed at Billerica

  4. Sonic Booms Produced by United States Air Force and United States Navy Aircraft: Measured Data

    DTIC Science & Technology

    1991-01-01

    29791 . 0.1 -. 0097 259. 12:03:41 1.268 68028. 37. 29793. 0.1 -. 0276 259. 12:03:42 1.268 66713. 85 29794. 0.1 -. 0129 259. 12:03:43 1.268 65400. 134...3811. 29793. -0.1 0.1585 253. 10:49:25 1.270 62762. -3896. 29791 , -0.1 0.1404 253. 10:49:26 1.273 61452. -3981. 29788. -0.1 0.0582 253. 10:49:27

  5. 15 CFR 904.253 - Closing of record.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Hearings § 904.253 Closing of record. At the conclusion of the hearing, the...

  6. 15 CFR 904.253 - Closing of record.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL REGULATIONS CIVIL PROCEDURES Hearing and Appeal Procedures Hearings § 904.253 Closing of record. At the conclusion of the hearing, the...

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Xinle

    In conclusion, we have for the first time developed a novel solid base catalyst, Ndoped MOF-253 derived porous carbons (Cz-MOF-253). Cz-MOF-253 is highly porous and exhibit high efficiency in Knoevenagel condensation reaction. Furthermore, Cz-MOF-253 is robust and can be reused up to five times. In comparison, the analogous nitrogen-free catalyst-Cz-DUT-5, and other nitrogen- MOFs derived carbon showed an inferior performance. Moreover, the high basicity and porous nature enable the design of bifunctional catalyst and facilitate tandem condensation-hydrogenation reactions. This work delineates the first attempt that demonstrates MOF-derived carbons as solid base catalyst and its potential application in tandem catalysis. Futuremore » work on exploring new catalytic reactions based on such porous Lewis basic MOF-derived carbons is currently underway.« less

  8. 28 CFR 2.53 - Mandatory parole.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Federal Juvenile Delinquency Act, or the provisions of 5010(c) of the Youth Corrections Act) serving a..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.53 Mandatory...

  9. 28 CFR 2.53 - Mandatory parole.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Federal Juvenile Delinquency Act, or the provisions of 5010(c) of the Youth Corrections Act) serving a..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.53 Mandatory...

  10. 28 CFR 2.53 - Mandatory parole.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Federal Juvenile Delinquency Act, or the provisions of 5010(c) of the Youth Corrections Act) serving a..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.53 Mandatory...

  11. 28 CFR 2.53 - Mandatory parole.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Federal Juvenile Delinquency Act, or the provisions of 5010(c) of the Youth Corrections Act) serving a..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.53 Mandatory...

  12. 28 CFR 2.53 - Mandatory parole.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Federal Juvenile Delinquency Act, or the provisions of 5010(c) of the Youth Corrections Act) serving a..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code Prisoners and Parolees § 2.53 Mandatory...

  13. 14 CFR 253.9 - Retroactive changes to contracts of carriage

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

  14. 14 CFR 253.9 - Retroactive changes to contracts of carriage.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

  15. 14 CFR 253.9 - Retroactive changes to contracts of carriage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

  16. 14 CFR 253.9 - Retroactive changes to contracts of carriage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

  17. 14 CFR 253.9 - Retroactive changes to contracts of carriage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS NOTICE OF TERMS OF CONTRACT OF CARRIAGE § 253.9 Retroactive... bought a ticket any material amendment to its contract of carriage that has significant negative...

  18. [Influence of cold spot temperature on 253.7 nm resonance spectra line of electrodeless discharge lamps].

    PubMed

    Dong, Jin-yang; Zhang, Gui-xin; Wang, Chang-quan

    2012-01-01

    As a kind of new electric light source, electrodeless discharge lamps are of long life, low mercury and non-stroboscopic light. The lighting effect of electrodeless discharge lamps depends on the radiation efficiency of 253.7 nm resonance spectra line to a large extent. The influence of cold temperature on 253.7 nm resonance spectra line has been studied experimentally by atomic emission spectral analysis. It was found that the radiation efficiency of 253.7 nm resonance spectra line is distributed in a nearly normal fashion with the variation of cold spot temperature, in other words, there is an optimum cold spot temperature for an electrodeless discharge lamp. At last, the results of experiments were analyzed through gas discharge theory, which offers guidance to the improvement of lighting effect for electrodeless discharge lamps.

  19. 30 CFR 253.31 - How can I use a surety bond as OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for Demonstrating OSFR § 253.31... Form MMS-1020; and (4) Be in compliance with applicable statutes regulating surety company...

  20. 253. Mabry Mill. The varying roof lines and siding gives ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    253. Mabry Mill. The varying roof lines and siding gives the mill an interesting texture, increasing its photogenic value. Looking north. - Blue Ridge Parkway, Between Shenandoah National Park & Great Smoky Mountains, Asheville, Buncombe County, NC

  1. 30 CFR 253.62 - What are the designated applicant's notification obligations regarding a claim?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Claims for Oil-Spill Removal Costs and Damages § 253.62 What are the designated applicant's notification obligations...

  2. 30 CFR 253.62 - What are the designated applicant's notification obligations regarding a claim?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Claims for Oil-Spill Removal Costs and Damages § 253.62 What are the...

  3. 30 CFR 253.1 - What is the purpose of this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES General § 253.1 What... covered offshore facilities (COFs) under Title I of the Oil Pollution Act of 1990 (OPA), as amended, 33 U...

  4. 7 CFR 1220.253 - Personal liability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Miscellaneous § 1220.253 Personal liability. No... Soybean Boards, acting pursuant to authority provided in this subpart, shall be held personally...

  5. 37 CFR 253.6 - Performance of musical compositions by other public broadcasting entities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CERTAIN COPYRIGHTED WORKS IN CONNECTION WITH NONCOMMERCIAL EDUCATIONAL BROADCASTING § 253.6 Performance of... this section shall furnish to ASCAP, BMI and SESAC, upon request, a music-use report during one week of...

  6. 253. Photocopy of photograph from Georgia Historical Society Cordray Foltz, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    253. Photocopy of photograph from Georgia Historical Society Cordray Foltz, photographer, date unknown WEST PARK AND BROAD STREETS - Savannah Victorian Historic District, Bounded by Gwinnett, East Broad, West Broad Street & Anderson Lane, Savannah, Chatham County, GA

  7. 30 CFR 253.24 - When I submit audited annual financial statements to verify my net worth, what standards must...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for Demonstrating OSFR § 253.24 When I...

  8. 30 CFR 253.45 - Where do I send my OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Oil Spill Financial Responsibility Program, 1201 Elmwood Park Boulevard, New Orleans, Louisiana 70123. ... Section 253.45 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Requirements for Submitting OSFR Information...

  9. 7 CFR 1951.253 - Objectives.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS (CONTINUED) SERVICING AND COLLECTIONS Analyzing Credit Needs and Graduation of Borrowers § 1951.253 Objectives. (a) [Reserved] (b) Borrowers must graduate to other credit at reasonable rates and... other credit. (2) Other credit is available from a commercial lender at reasonable rates and terms. In...

  10. The NEAR Spacecraft's Flyby of Asteroid 253 Mathilde

    NASA Technical Reports Server (NTRS)

    Yeomans, D. K.; Barriot, J. P.; Dunham, D. W.; Farquhar, R. W.; Helfrich, C. E.; Konopliv, A. S.; McAdams, J. V.; Miller, J. K.; Owen, W. M., Jr.; Scheeres, D. J.; hide

    1997-01-01

    The Terminal navigation of the NEAR spacecraft during its close flyby of asteroid 253 Mathilde involved coordinated efforts first to determine the heliocentric orbits of the spacecraft and Mathilde and then to determine the relative trajectory of the spacecraft with respect to Mathilde.

  11. 40 CFR 61.253 - Determining compliance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 61.253 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standards for Radon Emissions... measurements are to be made over a one year period, EPA shall be provided with a schedule of the measurement...

  12. Altered Redox Status Accompanies Progression to Metastatic Human Bladder Cancer

    PubMed Central

    Hempel, Nadine; Ye, Hanqing; Abessia, Bryan; Mian, Badar; Melendez, J. Andres

    2009-01-01

    The role of reactive oxygen species (ROS) in bladder cancer progression remains an unexplored field. Expression levels of enzymes regulating ROS levels are often altered in cancer. Search of publicly available micro-array data reveals that expression of mitochondrial manganese superoxide dismutase (Sod2), responsible for the conversion of superoxide (O2-.) to hydrogen peroxide (H2O2), is consistently increased in high grade and advanced stage bladder tumors. Here we aim to identify the role of Sod2 expression and ROS in bladder cancer. Using an in vitro human bladder tumor model we monitored the redox state of both non-metastatic (253J) and highly metastatic (253J B-V) bladder tumor cell lines. 253J B-V cells displayed significantly higher Sod2 protein and activity levels compared to their parental 253J cell line. The increase in Sod2 expression was accompanied by a significant decrease in catalase activity, resulting in a net increase in H2O2 production in the 253J B-V line. Expression of pro-metastatic and –angiogenic factors, matrix metalloproteinase 9 (MMP-9) and vascular endothelial derived growth factor (VEGF), respectively, were similarly upregulated in the metastatic line. Expression of both MMP-9 and VEGF were shown to be H2O2-dependent, as removal of H2O2 by overexpression of catalase attenuated their expression. Similarly, expression of catalase effectively reduced the clonogenic activity of 253J B-V cells. These findings indicate that metastatic bladder cancer cells display an altered antioxidant expression profile, resulting in a net increase in ROS production, which leads to the induction of redox-sensitive pro-tumorigenic and pro-metastatic genes such as VEGF and MMP-9. PMID:18930813

  13. A simple screening method for determining knowledge of the appropriate levels of activity and risk behaviour in young people with congenital cardiac conditions.

    PubMed

    Kendall, Lynne; Parsons, Jonathan M; Sloper, Patricia; Lewin, Robert J P

    2007-04-01

    To assess a novel method for assessing risk and providing advice about activity to children and young people with congenital cardiac disease and their parents. Questionnaire survey in outpatient clinics at a tertiary centre dealing with congenital cardiac disease, and 6 peripheral clinics. Children or their parents completed a brief questionnaire. If this indicated a desire for help, or a serious mismatch between advised and real level of activity, they were telephoned by a physiotherapist. MAIN MEASURES OF OUTCOME: Knowledge about appropriate levels of activity, and identification of the number exercising at an unsafe level, the number seeking help, and the type of help required. 253/258 (98.0%) questionnaires were returned, with 119/253 (47.0%) showing incorrect responses in their belief about their advised level of exercise; 17/253 (6.7%) had potentially dangerous overestimation of exercise. Asked if they wanted advice 93/253 (36.8%) said "yes", 43/253 (17.0%) "maybe", and 117/253 (46.2%) "no". Of those contacted by phone to give advice, 72.7% (56/77) required a single contact and 14.3% (11/77) required an intervention that required more intensive contact lasting from 2 up to 12 weeks. Of the cohort, 3.9% (3/77) were taking part in activities that put them at significant risk. There is a significant lack of knowledge about appropriate levels of activity, and a desire for further advice, in children and young people with congenital cardiac disease. A few children may be at very significant risk. These needs can be identified, and clinical risk reduced, using a brief self-completed questionnaire combined with telephone follow-up from a suitably knowledgeable physiotherapist.

  14. 7 CFR 1924.253 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Serious defects in or improper installation of heating systems or central air conditioning. (4) Defects in... CONSTRUCTION AND REPAIR Complaints and Compensation for Construction Defects § 1924.253 Definitions. As used in..., smoke detectors, railings, etc., as well as failure to provide or properly install devices to aid...

  15. 7 CFR 1924.253 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Serious defects in or improper installation of heating systems or central air conditioning. (4) Defects in... CONSTRUCTION AND REPAIR Complaints and Compensation for Construction Defects § 1924.253 Definitions. As used in..., smoke detectors, railings, etc., as well as failure to provide or properly install devices to aid...

  16. 7 CFR 1924.253 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Serious defects in or improper installation of heating systems or central air conditioning. (4) Defects in... CONSTRUCTION AND REPAIR Complaints and Compensation for Construction Defects § 1924.253 Definitions. As used in..., smoke detectors, railings, etc., as well as failure to provide or properly install devices to aid...

  17. 7 CFR 1924.253 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Serious defects in or improper installation of heating systems or central air conditioning. (4) Defects in... CONSTRUCTION AND REPAIR Complaints and Compensation for Construction Defects § 1924.253 Definitions. As used in..., smoke detectors, railings, etc., as well as failure to provide or properly install devices to aid...

  18. 49 CFR 173.320 - Cryogenic liquids; exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... atmospheric gases and helium: (1) During loading and unloading operations (pressure rises may exceed 25.3 psig...; exceptions. (a) Atmospheric gases and helium, cryogenic liquids, in Dewar flasks, insulated cylinders... the pressure in such packagings will not exceed 25.3 psig under ambient temperature conditions during...

  19. 42 CFR 84.253 - Chemical-cartridge respirators; requirements and tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Chemical-cartridge respirators; requirements and... DEVICES Special Use Respirators § 84.253 Chemical-cartridge respirators; requirements and tests. (a... for chemical-cartridge respirators prescribed in Subpart L of this part are applicable to replaceable...

  20. 7 CFR 253.8 - Administrative disqualification procedures for intentional program violation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS § 253.8..., or withholds facts in order to obtain Food Distribution Program benefits which the household is not...

  1. 7 CFR 253.8 - Administrative disqualification procedures for intentional program violation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS § 253.8..., or withholds facts in order to obtain Food Distribution Program benefits which the household is not...

  2. 42 CFR 84.253 - Chemical-cartridge respirators; requirements and tests.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Chemical-cartridge respirators; requirements and... DEVICES Special Use Respirators § 84.253 Chemical-cartridge respirators; requirements and tests. (a... for chemical-cartridge respirators prescribed in Subpart L of this part are applicable to replaceable...

  3. 7 CFR 253.11 - Administrative funds for State agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 253.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION.... Administrative costs must be included in annual or revised budget information submitted by the State agency to... beginning of a Federal fiscal year. The application shall include budget information, reflecting by category...

  4. 7 CFR 253.11 - Administrative funds for State agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 253.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION.... Administrative costs must be included in annual or revised budget information submitted by the State agency to... beginning of a Federal fiscal year. The application shall include budget information, reflecting by category...

  5. 48 CFR 208.7005 - Military interdepartmental purchase requests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Military interdepartmental... Coordinated Acquisition 208.7005 Military interdepartmental purchase requests. Follow the procedures at— (a) PGI 253.208-1 when using DD Form 448, Military Interdepartmental Purchase Request; and (b) PGI 253.208...

  6. 14 CFR 25.253 - High-speed characteristics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false High-speed characteristics. 25.253 Section...-speed characteristics. (a) Speed increase and recovery characteristics. The following speed increase and... inadvertent speed increases (including upsets in pitch and roll) must be simulated with the airplane trimmed...

  7. 14 CFR 25.253 - High-speed characteristics.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false High-speed characteristics. 25.253 Section...-speed characteristics. (a) Speed increase and recovery characteristics. The following speed increase and... inadvertent speed increases (including upsets in pitch and roll) must be simulated with the airplane trimmed...

  8. Spectral Energy Distribution and Radio Halo of NGC 253 at Low Radio Frequencies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kapińska, A. D.; Staveley-Smith, L.; Meurer, G. R.

    We present new radio continuum observations of NGC 253 from the Murchison Widefield Array at frequencies between 76 and 227 MHz. We model the broadband radio spectral energy distribution for the total flux density of NGC 253 between 76 MHz and 11 GHz. The spectrum is best described as a sum of a central starburst and extended emission. The central component, corresponding to the inner 500 pc of the starburst region of the galaxy, is best modeled as an internally free–free absorbed synchrotron plasma, with a turnover frequency around 230 MHz. The extended emission component of the spectrum of NGCmore » 253 is best described as a synchrotron emission flattening at low radio frequencies. We find that 34% of the extended emission (outside the central starburst region) at 1 GHz becomes partially absorbed at low radio frequencies. Most of this flattening occurs in the western region of the southeast halo, and may be indicative of synchrotron self-absorption of shock-reaccelerated electrons or an intrinsic low-energy cutoff of the electron distribution. Furthermore, we detect the large-scale synchrotron radio halo of NGC 253 in our radio images. At 154–231 MHz the halo displays the well known X-shaped/horn-like structure, and extends out to ∼8 kpc in the z -direction (from the major axis).« less

  9. 40 CFR 60.253 - Standards for pneumatic coal-cleaning equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Standards for pneumatic coal-cleaning... PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Coal Preparation and Processing Plants § 60.253 Standards for pneumatic coal-cleaning equipment. (a) On and after...

  10. 30 CFR 1206.253 - Coal subject to royalties-general provisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Coal subject to royalties-general provisions..., DEPARTMENT OF THE INTERIOR Natural Resources Revenue PRODUCT VALUATION Federal Coal § 1206.253 Coal subject to royalties—general provisions. (a) All coal (except coal unavoidably lost as determined by BLM...

  11. 40 CFR 60.253 - Standards for pneumatic coal-cleaning equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Standards for pneumatic coal-cleaning... PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Coal Preparation and Processing Plants § 60.253 Standards for pneumatic coal-cleaning equipment. (a) On and after...

  12. 40 CFR 60.253 - Standards for pneumatic coal-cleaning equipment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Standards for pneumatic coal-cleaning... PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Coal Preparation and Processing Plants § 60.253 Standards for pneumatic coal-cleaning equipment. (a) On and after...

  13. 40 CFR 60.253 - Standards for pneumatic coal-cleaning equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standards for pneumatic coal-cleaning... PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Coal Preparation and Processing Plants § 60.253 Standards for pneumatic coal-cleaning equipment. (a) On and after...

  14. 40 CFR 60.253 - Standards for pneumatic coal-cleaning equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Standards for pneumatic coal-cleaning... PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Coal Preparation and Processing Plants § 60.253 Standards for pneumatic coal-cleaning equipment. (a) On and after...

  15. 40 CFR 52.253 - Metal surface coating thinner and reducer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.253 Metal surface... conform to paragraph (k) of § 52.254 so as to be defined as a nonphotochemically reactive solvent. (d...-photochemically reactive solvent. (e) If there is an inadequate supply of necessary solvent ingredients needed in...

  16. 7 CFR 253.6 - Eligibility of households.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... special diets, incurred by any household member who is elderly or disabled as defined in § 253.2 of this... allowable medical costs are those permitted at 7 CFR 273.9(d)(3) for the Supplemental Nutrition Assistance...

  17. 40 CFR 52.253 - Metal surface coating thinner and reducer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false Metal surface coating thinner and... PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.253 Metal surface... Counties Air Basin portion). (iii) This section is rescinded for metal parts and products coaters which are...

  18. 12. Photographic copy of construction drawing, dated September 29, 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photographic copy of construction drawing, dated September 29, 1932, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-25?? SDO 163 (ELEVATIONS) - Selfridge Field, Building Nos. 246 & 253, 246 Birch Street & 253 Wagner Street, Mount Clemens, Macomb County, MI

  19. 18 CFR 367.2530 - Account, 253, Other deferred credits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account, 253, Other deferred credits. 367.2530 Section 367.2530 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT...

  20. 20 CFR 632.253 - Special operating provisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.253... assistance from the summer program, and youth who remain in school but are likely to be confronted with... provided in the summer program at no cost, or at minimum cost, to the summer program; (d) Assure that...

  1. VizieR Online Data Catalog: Globular cluster candidates in NGC253 (Cantiello+, 2018)

    NASA Astrophysics Data System (ADS)

    Cantiello, M.; Grado, A.; Rejkuba, M.; Arnaboldi, M.; Capaccioli, M.; Greggio, L.; Iodice, E.; Limatola, L.

    2017-11-01

    Photometric catalogs for globular cluster (GC) candidates over the 1 sq. degree area around NGC253. The catalogues are based on ugri-band photometry from the VST data, and JKs photometry from VISTA. Aperture magnitudes, corrected for aperture correction are reported. (1 data file).

  2. 48 CFR 52.253-1 - Computer Generated Forms.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Computer Generated Forms....253-1 Computer Generated Forms. As prescribed in FAR 53.111, insert the following clause: Computer... by the Federal Acquisition Regulation (FAR) may be submitted on a computer generated version of the...

  3. 48 CFR 52.253-1 - Computer Generated Forms.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Computer Generated Forms....253-1 Computer Generated Forms. As prescribed in FAR 53.111, insert the following clause: Computer... by the Federal Acquisition Regulation (FAR) may be submitted on a computer generated version of the...

  4. 48 CFR 52.253-1 - Computer Generated Forms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Computer Generated Forms....253-1 Computer Generated Forms. As prescribed in FAR 53.111, insert the following clause: Computer... by the Federal Acquisition Regulation (FAR) may be submitted on a computer generated version of the...

  5. 50 CFR 216.253 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to Conducting Precision Strike Weapon Missions in the Gulf of Mexico § 216.253... shall: (a) Take any marine mammal not specified in § 216.250(b); (b) Take any marine mammal specified in...

  6. 7 CFR 253.10 - Commodity control, storage and distribution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 253.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION...-condition commodities. The State agency shall immediately notify the appropriate Food and Nutrition Service... Management and Budget under control number 0584-0071) (44 U.S.C. 3506) [44 FR 35928, June 19, 1979, as...

  7. 7 CFR 253.10 - Commodity control, storage and distribution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 253.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION...-condition commodities. The State agency shall immediately notify the appropriate Food and Nutrition Service... Management and Budget under control number 0584-0071) (44 U.S.C. 3506) [44 FR 35928, June 19, 1979, as...

  8. 7 CFR 253.10 - Commodity control, storage and distribution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Section 253.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION...-condition commodities. The State agency shall immediately notify the appropriate Food and Nutrition Service... Management and Budget under control number 0584-0071) (44 U.S.C. 3506) [44 FR 35928, June 19, 1979, as...

  9. 7 CFR 253.10 - Commodity control, storage and distribution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 253.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION...-condition commodities. The State agency shall immediately notify the appropriate Food and Nutrition Service... Management and Budget under control number 0584-0071) (44 U.S.C. 3506) [44 FR 35928, June 19, 1979, as...

  10. 48 CFR 52.253-1 - Computer Generated Forms.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Computer Generated Forms....253-1 Computer Generated Forms. As prescribed in FAR 53.111, insert the following clause: Computer... by the Federal Acquisition Regulation (FAR) may be submitted on a computer generated version of the...

  11. 48 CFR 52.253-1 - Computer Generated Forms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Computer Generated Forms....253-1 Computer Generated Forms. As prescribed in FAR 53.111, insert the following clause: Computer... by the Federal Acquisition Regulation (FAR) may be submitted on a computer generated version of the...

  12. Too much carbon in NGC253

    NASA Technical Reports Server (NTRS)

    Harrison, Andrew; Brand, Peter; Puxley, Phil; Russell, Adrian

    1995-01-01

    We have observed C(exp 0) across the nucleus of the starburst galaxy NGC253. C(exp 0) is very bright and we find N(C(exp 0))/N(CO) is between 1.5 and 2.3 across the nucleus. Existing PDR models cannot explain the observed C(exp 0) intensity. The size of the observed region seems to rule out 'simultaneous very early time chemistry' across the nucleus. Chemical models in which C(sup 0)/CO is enhanced deep in molecular clouds by large fluxes of cosmic rays also struggle to explain our observations. The most plausible explanation for the observed C(exp 0) is that the C/O elemental ratio is enhanced in NGC253.

  13. 42 CFR 441.253 - Sterilization of a mentally competent individual aged 21 or older.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Sterilization of a mentally competent individual... LIMITS APPLICABLE TO SPECIFIC SERVICES Sterilizations § 441.253 Sterilization of a mentally competent individual aged 21 or older. FFP is available in expenditures for the sterilization of an individual only if...

  14. 30 CFR 1206.253 - Coal subject to royalties-general provisions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Coal subject to royalties-general provisions... INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.253 Coal subject to royalties—general provisions. (a) All coal (except coal unavoidably lost as determined by BLM under 43 CFR part 3400...

  15. 30 CFR 206.253 - Coal subject to royalties-general provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Coal subject to royalties-general provisions... MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Coal § 206.253 Coal subject to royalties—general provisions. (a) All coal (except coal unavoidably lost as determined by BLM under 43 CFR part 3400) from a...

  16. 30 CFR 1206.253 - Coal subject to royalties-general provisions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Coal subject to royalties-general provisions... INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.253 Coal subject to royalties—general provisions. (a) All coal (except coal unavoidably lost as determined by BLM under 43 CFR part 3400...

  17. 30 CFR 1206.253 - Coal subject to royalties-general provisions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Coal subject to royalties-general provisions... INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.253 Coal subject to royalties—general provisions. (a) All coal (except coal unavoidably lost as determined by BLM under 43 CFR part 3400...

  18. 14 CFR 21.253 - Type certificates: application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... technical data and type inspection report in the technical data file required by § 21.293(a)(1)(i), a statement certifying that this has been done; (5) A proposed type certificate data sheet; and (6) An... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Type certificates: application. 21.253...

  19. Biotechnology Process Engineering Center at MIT Home

    Science.gov Websites

    Research Summary Research Details of Project A (Stem Cell Vehicle Subthrust) and Project B (Targeted ) 253-0805 | Facsimile (617) 253-2400 | e-mail: bpec-www@mit.edu Current NSF ERC-Supported Research Vehicle Subthrust) Other Projects Related to NSF-Funded Research (coming soon) Home | People | Education

  20. 11. Photographic copy of construction drawing, dated July 29, 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of construction drawing, dated July 29, 1932, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2511 SDO 139 (FLOOR PLANS) - Selfridge Field, Building Nos. 246 & 253, 246 Birch Street & 253 Wagner Street, Mount Clemens, Macomb County, MI

  1. 7 CFR 1710.253 - Engineering and cost studies-addition of generation capacity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Engineering and cost studies-addition of generation... TO ELECTRIC LOANS AND GUARANTEES Construction Work Plans and Related Studies § 1710.253 Engineering... engineering and cost studies as specified by RUS. The studies shall cover a period from the beginning of the...

  2. 7 CFR 1710.253 - Engineering and cost studies-addition of generation capacity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Engineering and cost studies-addition of generation... TO ELECTRIC LOANS AND GUARANTEES Construction Work Plans and Related Studies § 1710.253 Engineering... engineering and cost studies as specified by RUS. The studies shall cover a period from the beginning of the...

  3. 7 CFR 1710.253 - Engineering and cost studies-addition of generation capacity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Engineering and cost studies-addition of generation... TO ELECTRIC LOANS AND GUARANTEES Construction Work Plans and Related Studies § 1710.253 Engineering... engineering and cost studies as specified by RUS. The studies shall cover a period from the beginning of the...

  4. 7 CFR 1710.253 - Engineering and cost studies-addition of generation capacity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Engineering and cost studies-addition of generation... TO ELECTRIC LOANS AND GUARANTEES Construction Work Plans and Related Studies § 1710.253 Engineering... engineering and cost studies as specified by RUS. The studies shall cover a period from the beginning of the...

  5. 7 CFR 1710.253 - Engineering and cost studies-addition of generation capacity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Engineering and cost studies-addition of generation... TO ELECTRIC LOANS AND GUARANTEES Construction Work Plans and Related Studies § 1710.253 Engineering... engineering and cost studies as specified by RUS. The studies shall cover a period from the beginning of the...

  6. 24 CFR 236.253 - Premiums-operating loss loans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Obligations for Mortgage Insurance § 236.253 Premiums—operating loss loans. All of the provisions of § 207.252a of this chapter relating to mortgage insurance premiums on operating loss loans shall apply to... Act the mortgage insurance premiums due in accordance with § 207.252a shall be calculated on the basis...

  7. 24 CFR 236.253 - Premiums-operating loss loans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Obligations for Mortgage Insurance § 236.253 Premiums—operating loss loans. All of the provisions of § 207.252a of this chapter relating to mortgage insurance premiums on operating loss loans shall apply to... Act the mortgage insurance premiums due in accordance with § 207.252a shall be calculated on the basis...

  8. 43 CFR 30.253 - How must minors or other legal incompetents be represented?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false How must minors or other legal... Interior INDIAN PROBATE HEARINGS PROCEDURES Miscellaneous Provisions § 30.253 How must minors or other legal incompetents be represented? Minors and other legal incompetents who are interested parties must...

  9. 43 CFR 30.253 - How must minors or other legal incompetents be represented?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How must minors or other legal... Interior INDIAN PROBATE HEARINGS PROCEDURES Miscellaneous Provisions § 30.253 How must minors or other legal incompetents be represented? Minors and other legal incompetents who are interested parties must...

  10. Class I methanol masers in NGC 253: Alcohol at the end of the bar

    NASA Astrophysics Data System (ADS)

    Ellingsen, S. P.; Chen, X.; Breen, S. L.; Qiao, H.-H.

    2017-11-01

    We have used the Australia Telescope Compact Array to observe the 36.2-GHz class I methanol maser emission towards NGC 253 and find that it is located at the interface between the nuclear ring and both ends of the galactic bar. This is thought to be the location of the inner Linblad resonance and we suggest that the maser emission in this region is likely due to large-scale cloud-cloud collisions. We have detected the first extragalactic 44.1-GHz class I methanol maser and find that it is associated with the 36.2-GHz maser emission. In contrast to the class I methanol masers found in Galactic star formation regions, the 44.1-GHz emission in NGC 253 is two orders of magnitude weaker than the 36.2-GHz masers. Both the 36.2- and 44.1-GHz emission is orders of magnitude stronger than expected from typical high-mass star formation regions. This demonstrates that the luminous class I methanol masers observed in NGC 253 are significantly different from those associated with Galactic star formation.

  11. 1,25D3 differentially suppresses bladder cancer cell migration and invasion through the induction of miR-101-3p.

    PubMed

    Ma, Yingyu; Luo, Wei; Bunch, Brittany L; Pratt, Rachel N; Trump, Donald L; Johnson, Candace S

    2017-09-01

    Metastasis is the major cause of bladder cancer death. 1,25D 3 , the active metabolite of vitamin D, has shown anti-metastasis activity in several cancer model systems. However, the role of 1,25D 3 in migration and invasion in bladder cancer is unknown. To investigate whether 1,25D 3 affects migration and invasion, four human bladder cell lines with different reported invasiveness were selected: low-invasive T24 and 253J cells and highly invasive 253J-BV and TCCSUP cells. All of the four bladder cancer cells express endogenous and inducible vitamin D receptor (VDR) as examined by immunoblot analysis. 1,25D 3 had no effect on the proliferation of bladder cancer cells as assessed by MTT assay. In contrast, 1,25D 3 suppressed migration and invasion in the more invasive 253J-BV and TCCSUP cells, but not in the low-invasive 253J and T24 cells using "wound" healing, chemotactic migration and Matrigel-based invasion assays. 1,25D 3 promoted the expression of miR-101-3p and miR-126-3p in 253J-BV cells as examined by qRT-PCR. miR-101-3p inhibitor partially abrogated and pre-miR-101-3p further suppressed the inhibition of 1,25D 3 on migration and invasion in 253J-BV cells. Further, 1,25D 3 enhanced VDR recruitment to the promoter region of miR-101-3p using ChIP-qPCR assay. 1,25D 3 enhanced the promoter activity of miR-101-3p as evaluated by luciferase reporter assay. Taken together, 1,25D 3 suppresses bladder cancer cell migration and invasion in two invasive/migration competent lines but not in two less invasive/motile lines, which is partially through the induction of miR-101-3p expression at the transcriptional level.

  12. p38α phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles.

    PubMed

    Ettelaie, Camille; Elkeeb, Azza M; Maraveyas, Anthony; Collier, Mary Elizabeth W

    2013-03-01

    We previously showed that the phosphorylation of Ser253 within the cytoplasmic domain of human tissue factor (TF) initiates the incorporation and release of this protein into cell-derived microparticles. Furthermore, subsequent phosphorylation of Ser258 terminates this process. However, the identity of the kinase responsible for the phosphorylation of Ser258 and mode of action of this enzyme remain unknown. In this study, p38α was identified as the proline-directed kinase capable of phosphorylating Ser258 specifically, and without any detectable activity towards Ser253. Furthermore, using synthetic peptides, it was shown that the Km for the reaction decreased by approximately 10 fold on substitution of Ser253 with phospho-Ser253. Either inhibition of p38 using SB202190 or knockdown of p38α expression in coronary artery endothelial cells overexpressing wild-type TF, resulted in decreased phosphorylation of Ser258, following activation of cells with PAR2-agonist peptide (PAR2-AP). In agreement with our previous data, inhibition of phosphorylation of this residue maintained the release of TF. Activation of PAR2 in cells transfected to overexpress TF, resulted in two separate peaks of p38 activity at approximately 40 and 120 min post-activation. Furthermore, overexpression of Ala253-substituted TF enhanced the second p38 activation peak. However, the second peak was absent in cells devoid of TF or in cells overexpressing the Asp253-substituted TF. Our data clearly identifies p38α as a kinase capable of phosphorylating Ser258 within the cytoplasmic domain of TF. Moreover, it appears that the presence of TF within the cells regulates the late activation of p38 and consequently the termination of TF release into microparticles. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. 1,25D3 differentially suppresses bladder cancer cell migration and invasion through the induction of miR-101-3p

    PubMed Central

    Ma, Yingyu; Luo, Wei; Bunch, Brittany L.; Pratt, Rachel N.; Trump, Donald L.; Johnson, Candace S.

    2017-01-01

    Metastasis is the major cause of bladder cancer death. 1,25D3, the active metabolite of vitamin D, has shown anti-metastasis activity in several cancer model systems. However, the role of 1,25D3 in migration and invasion in bladder cancer is unknown. To investigate whether 1,25D3 affects migration and invasion, four human bladder cell lines with different reported invasiveness were selected: low-invasive T24 and 253J cells and highly invasive 253J-BV and TCCSUP cells. All of the four bladder cancer cells express endogenous and inducible vitamin D receptor (VDR) as examined by immunoblot analysis. 1,25D3 had no effect on the proliferation of bladder cancer cells as assessed by MTT assay. In contrast, 1,25D3 suppressed migration and invasion in the more invasive 253J-BV and TCCSUP cells, but not in the low-invasive 253J and T24 cells using “wound” healing, chemotactic migration and Matrigel-based invasion assays. 1,25D3 promoted the expression of miR-101-3p and miR-126-3p in 253J-BV cells as examined by qRT-PCR. miR-101-3p inhibitor partially abrogated and pre-miR-101-3p further suppressed the inhibition of 1,25D3 on migration and invasion in 253J-BV cells. Further, 1,25D3 enhanced VDR recruitment to the promoter region of miR-101-3p using ChIP-qPCR assay. 1,25D3 enhanced the promoter activity of miR-101-3p as evaluated by luciferase reporter assay. Taken together, 1,25D3 suppresses bladder cancer cell migration and invasion in two invasive/migration competent lines but not in two less invasive/motile lines, which is partially through the induction of miR-101-3p expression at the transcriptional level. PMID:28947955

  14. 40 CFR 98.172 - GHGs to report.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... combustion units include, but are not limited to, by-product recovery coke oven battery combustion stacks... flares that burn blast furnace gas or coke oven gas according to the procedures in § 98.253(b)(1) of...)(B) and § 98.253(b)(1)(iii)(C), you must use the default CO2 emission factors for coke oven gas and...

  15. 40 CFR 98.172 - GHGs to report.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... combustion units include, but are not limited to, by-product recovery coke oven battery combustion stacks... flares that burn blast furnace gas or coke oven gas according to the procedures in § 98.253(b)(1) of...)(B) and § 98.253(b)(1)(iii)(C), you must use the default CO2 emission factors for coke oven gas and...

  16. 40 CFR 98.172 - GHGs to report.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... combustion units include, but are not limited to, by-product recovery coke oven battery combustion stacks... flares that burn blast furnace gas or coke oven gas according to the procedures in § 98.253(b)(1) of...)(B) and § 98.253(b)(1)(iii)(C), you must use the default CO2 emission factors for coke oven gas and...

  17. 40 CFR 98.172 - GHGs to report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... combustion units include, but are not limited to, by-product recovery coke oven battery combustion stacks... flares that burn blast furnace gas or coke oven gas according to the procedures in § 98.253(b)(1) of...)(B) and § 98.253(b)(1)(iii)(C), you must use the default CO2 emission factors for coke oven gas and...

  18. 30 CFR 253.27 - When I submit audited annual financial statements to verify my unencumbered assets, what...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... financial statements to verify my unencumbered assets, what standards must they meet? Any audited annual financial statements that you submit must: (a) Meet the standards in § 253.24; and (b) Include a certification by the independent accountant who audited the financial statements that states: (1) The value of...

  19. 30 CFR 253.29 - How can I use insurance as OSFR evidence?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Be executed on one original insurance certificate (i.e., Form MMS-1019) for each OSFR layer (see... you provide to MMS as OSFR evidence may be divided into layers, subject to the following restrictions...; (2) No more than one insurance certificate may be used to cover each OSFR layer specified in § 253.13...

  20. 40 CFR 97.253 - Recordation of CAIR SO2 allowances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Recordation of CAIR SO2 allowances. 97... (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Tracking System § 97.253 Recordation of CAIR SO2 allowances. (a)(1) After a compliance account is...

  1. 40 CFR 96.253 - Recordation of CAIR SO2 allowances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Recordation of CAIR SO2 allowances. 96... (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS CAIR SO2 Allowance Tracking System § 96.253 Recordation of CAIR SO2 allowances. (a)(1) After a...

  2. 30 CFR 253.5 - What is the authority for collecting Oil Spill Financial Responsibility (OSFR) information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is the authority for collecting Oil Spill... SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES General § 253.5 What is the authority for collecting Oil Spill Financial Responsibility (OSFR) information...

  3. 30 CFR 253.61 - When is a guarantor subject to direct action for claims?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Claims for Oil-Spill Removal Costs and Damages § 253.61 When is a guarantor subject to direct action for...., oil-spill discharge or substantial threat of the discharge of oil) that is subject to claims under...

  4. 30 CFR 253.5 - What is the authority for collecting Oil Spill Financial Responsibility (OSFR) information?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What is the authority for collecting Oil Spill... MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES General § 253.5 What is the authority for collecting Oil Spill Financial...

  5. [253 patients with acute pancreatitis treated at the surgical clinic in Zagreb].

    PubMed

    Bakran, I

    1977-01-01

    253 patients with acute pancreatitis were treated in clinic for surgery in Zagreb through last 23 years. The most frequent cause of pancreatitis were diseases of biliary tract, obesity, vascular deseases, alcoholism etc. In the symtomatology, the pain was present in all patients and majority of them had abdominal symptoms as well. Most of the patients came to the treatment within the firsts 24 to 48 hours. Besides Trasylol various conservative therapy was applied and some patients were operated either on billiary ducts or on pancreas. 85 patients had to be operated again on billiary tract afterwards. From 253 patients treated 24 died (9,48%) because of the necrosis of pancreas and alterations on various other organs.

  6. Dense Molecular Gas Tracers in the Outflow of the Starburst Galaxy NGC 253

    NASA Astrophysics Data System (ADS)

    Walter, Fabian; Bolatto, Alberto D.; Leroy, Adam K.; Veilleux, Sylvain; Warren, Steven R.; Hodge, Jacqueline; Levy, Rebecca C.; Meier, David S.; Ostriker, Eve C.; Ott, Jürgen; Rosolowsky, Erik; Scoville, Nick; Weiss, Axel; Zschaechner, Laura; Zwaan, Martin

    2017-02-01

    We present a detailed study of a molecular outflow feature in the nearby starburst galaxy NGC 253 using ALMA. We find that this feature is clearly associated with the edge of NGC 253's prominent ionized outflow, has a projected length of ˜300 pc, with a width of ˜50 pc, and a velocity dispersion of ˜40 km s-1, which is consistent with an ejection from the disk about 1 Myr ago. The kinematics of the molecular gas in this feature can be interpreted (albeit not uniquely) as accelerating at a rate of 1 km s-1 pc-1. In this scenario, the gas is approaching an escape velocity at the last measured point. Strikingly, bright tracers of dense molecular gas (HCN, CN, HCO+, CS) are also detected in the molecular outflow: we measure an HCN(1-0)/CO(1-0) line ratio of ˜ 1/10 in the outflow, similar to that in the central starburst region of NGC 253 and other starburst galaxies. By contrast, the HCN/CO line ratio in the NGC 253 disk is significantly lower (˜ 1/30), similar to other nearby galaxy disks. This strongly suggests that the streamer gas originates from the starburst, and that its physical state does not change significantly over timescales of ˜1 Myr during its entrainment in the outflow. Simple calculations indicate that radiation pressure is not the main mechanism for driving the outflow. The presence of such dense material in molecular outflows needs to be accounted for in simulations of galactic outflows.

  7. 24 CFR 213.259a - Premiums-mortgages insured pursuant to section 238(c) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... All of the provisions of §§ 213.253 through 213.259 governing mortgage insurance premiums shall apply... mortgage insurance premiums due on such mortgages in accordance with §§ 213.253 through 213.259 shall be... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Premiums-mortgages insured pursuant...

  8. 24 CFR 213.259a - Premiums-mortgages insured pursuant to section 238(c) of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... All of the provisions of §§ 213.253 through 213.259 governing mortgage insurance premiums shall apply... mortgage insurance premiums due on such mortgages in accordance with §§ 213.253 through 213.259 shall be... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Premiums-mortgages insured pursuant...

  9. 30 CFR 253.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false How do I determine the worst case oil-spill... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 253.14 How do I determine the worst case oil-spill discharge volume? (a) To...

  10. 30 CFR 253.14 - How do I determine the worst case oil-spill discharge volume?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine the worst case oil-spill... INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Applicability and Amount of OSFR § 253.14 How do I determine the worst case oil-spill discharge volume? (a) To calculate the amount...

  11. Severe intellectual disability, West syndrome, Dandy-Walker malformation, and syndactyly in a patient with partial tetrasomy 17q25.3.

    PubMed

    Hackmann, Karl; Stadler, Anja; Schallner, Jens; Franke, Kathlen; Gerlach, Eva-Maria; Schrock, Evelin; Rump, Andreas; Fauth, Christine; Tinschert, Sigrid; Oexle, Konrad

    2013-12-01

    We report on a de novo 0.5 Mb triplication (partial tetrasomy) of chromosome 17q25.3 in a 10-year-old girl with severe intellectual disability, infantile seizures (West syndrome), moderate hearing loss, Dandy-Walker malformation, microcephaly, craniofacial dysmorphism, striking cutaneous syndactyly (hands 3-4, feet 2-3), joint laxity, and short stature. The triplication resulted from the unusual combination of a terminal duplication at 17qter and a cryptic translocation of an extra copy of the same segment onto chromosome 10qter. The breakpoint at 17q25.3 was located within the FOXK2 gene. SNP chip analysis suggested that the rearrangement occurred during paternal meiosis involving both paternal chromosomes 17. © 2013 Wiley Periodicals, Inc.

  12. The interstellar medium in the starburst regions of NGC 253 and NGC 3256

    NASA Astrophysics Data System (ADS)

    Carral, P.; Hollenbach, D. J.; Lord, S. D.; Colgan, S. W. J.; Haas, Michael R.; Rubin, R. H.; Erickson, E. F.

    1994-03-01

    We discuss observations of the (C II) 158 micrometers, (O I) 63 micrometers, (Si II) 35 micrometers, (O III) 52,88 micrometers, and (S III) 33 micrometers fine-structure transitions toward the central 45 seconds of the starburst galaxies NGC 253 and NGC 3256. The (C II) and (O I) emission probably originates in photodissociated gas at the surfaces of molecular clouds, although a small (less than or approximately 30%) contribution to the (C II) flux from H II regions cannot be ruled out. The (O III) and (S III) lines originate in H II regions and the (Si II) flux is best explained as originating in H II regions with some contribution from photodissociation regions (PDRs). The gas phase silicon abundance is nearly solar in NGC 253, which we interpret as evidence for grain destruction in the starburst region. We find that the photodissociated atomic gas has densities approximately 104/cu cm and temperature 200-300 K. About 2% of the gas is in this phase. The thermal gas pressure in the PDRs, P(PDR)/k approximately 1-3 x 106 K/cu cm, might represent the 'typical' interstellar gas pressure in starburst systems. The Far Ultraviolet (FUV) radiation fields illuminating the clouds are 103-104 stronger than the local Galactic FUV field and come from the contribution of many closely packed O and B stars. For the central 250 pc of NGC 253, we find that the H II gas has an average density ne is approximately 400/cu cm. This corresponds to a thermal pressure P(H II)/k approximately 7 x 106 K/cu cm which is approximately P(PDR)/k, suggesting that the ionized gas is in pressure equilibrium with the photodissociated gas at the surfaces of molecular clouds. The H II gas fills a significant fraction, approximately 0.01-0.3, of the volume between the clouds. The effective temperature of the ionizing stars in NGC 253 is greater than or approximately 34,500 K; 2 x 105 O7.5 stars would produce the observed Lyman continuum photon luminosity. The average separation between the stars is approximately 3 pc. Applying the simple model for the interstellar medium in galactic nuclei of Wolfire, Tielens, & Hollenbach (1990), we find the molecular gas in the central regions of NGC 253 and NGC 3256 to be distributed in a large number (5 x 103 to 5 x 105) of small (0.5-2 pc), dense (approximately 104/cu cm) clouds (or alternatively 'thin-flattened' structures) with volume filling factors 10-3 to 10-2, very different from the local Interstellar Medium (ISM) of the Galaxy. We suggest a self-consistent scenario for the ISM in NGC 253 in which clouds and H II gas are in pressure balance with a supernova-shocked, hot 1-3 x 106 K, low-density (approximately 104/cu cm), all pervasive medium. A feedback mechanism may be indicated in which the pressure generated by the supernovae compresses the molecular clouds and triggers further massive star formation. The similarity of ISM parameters deduced for NGC 253, NGC 3256, and M82 (Lord et al. 1993) suggests that the ISM properties are independent of the luminosity of the starburst or the triggering mechanism, but are rather endemic to starburst systems. The starburst in NGC 3256 appears to be a scaled-up version of the NGC 253 and M82 starbursts.

  13. Submillimetric study of nearby galaxies: A tool for new extragalactic molecules

    NASA Astrophysics Data System (ADS)

    Villicana Pedraza, Ilhuiyolitzin; Guesten, Rolf; Armijos Abendaño, Jairo; Carreto, Francisco; Martin, Sergio; Martin-Pintado, Jesus; Requena-Torres, Miguel; Perez-Beaupuits, Juan Pablo

    2016-07-01

    We present the first submillimetre line survey of extragalactic sources carried out by APEX, the results were presented inside of Villicana-Pedraza phd thesis in 2015. The surveys cover the 0.8 mm atmospheric window toward NGC253, NGC4945 and Arp220. We found HCN, C2H, CN, CS, C34S, HCO+, HNC, CO, N2H+, CH3OH are presents in all the sources, while 13CO,C18O and C17O, HNCO, H2CO, H2CS, SO, NO, SO2 were detected toward NGC253 and NGC4945, 13CN, *CO+, OCS, H2S in Arp220, 13CS, NH2CN, SiO in NGC253, and c-C3H2 in NGC4945 were detected. Column densities and rotation temperatures have been determinate using the Local Thermodinamical Equilibrium(LTE) line profile simulation and fitting in the MADCUBA IJ software. The differences found in the 32S/34S and 18O/17O ratios between the GC and the starburst galaxies NGC 4945 and NGC 253 suggest that the gas is less processed in the latter than in the GC. The high 18O/17O ratios in the galaxies NGC 4945 and NGC 253 suggest also material less processed in the nuclei of these galaxies than in the GC. This is consistent with the claim that 17O is a more representative primary product than 18O in stellar nucleosynthesis (Wilson and Rood 1994); Also, we did a Multitransitions study of H3O+ at 307GHz, 364GHz, 388GHz and 396GHz. From our non-LTE analysis of H3O+ in NGC253 with RADEX we found that the collisional excitation cannot explain the observed intensity of the ortho 396 GHz line. Excitation by radiation from the dust in the Far-IR can roughly explain the observations if the H2 densities are relatively low. From the derived H3O+ column densities we conclude that the chemistry of this molecule is dominated by ionization produce by the starburst in NGC253 (UV radiation from the O stars) and Arp 220 (cosmic rays from the supernovae) and likely from the AGN in NGC4549 (X-rays ); We report, for the first time, the tentative detection of the molecular ion HCNH+ (precursor of HCN and HNC) toward a galaxy, NGC4945, the abundance is much larger than the Galactic center in the Milky Way, abundance explain the claimed enhancement of HCN abundance in the AGN, due to the enhancement of the ionization rate by X-rays. The survey help us to find a lot of molecules including the tentative detection of *CH2NH, CH3C2H, HCNH+ in NGC253 and NGC4945 by first time in the extragalactic medium.

  14. Critical Problems in Very Large Scale Computer Systems

    DTIC Science & Technology

    1989-09-30

    N Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Anant Agarwal (617) 253-1448 William J. Dally (617) 253-6043 Srinivas Devadas ...rapidly switched between the ports. Labelling the terminal voltages ab.c. d. this attempts to enforce a constraint a - b = c - d. This is a reciprocal...Srinivas Devadas and his students have been focusing on the optimization ofcomibinational and sequen- tial circuits specified at the register

  15. 77 FR 68722 - Petition for Reconsideration of Action in Rulemaking Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... Manager of Navtech Radar Ltd., on behalf of Navtech Radar Ltd. and Bruce A. Olcott, for Squire Sanders LLP... 15.35 and 15.253 of the Commission's Rules Regarding Operation of Radar Systems in the 76-77 GHz Band; Amendment of Section 15.253 of the Commission's Rules to Permit Fixed Use of Radar in the 76-77 GHz Band (ET...

  16. Effects of management practices on wetland birds: Sora

    USGS Publications Warehouse

    Zimmerman, Amy L.; Jamison, Brent E.; Dechant, Jill A.; Johnson, Douglas H.; Goldade, Christopher M.; Church, James O.; Euliss, Betty R.

    2002-01-01

    This report has been downloaded from the Northern Prairie Wildlife Research Center WorldWide Web site, www.npwrc.usgs.gov/resource/literatr/wetbird/wetbird.htm. Please direct comments and suggestions to Douglas H. Johnson, Northern Prairie Wildlife Research Center, U.S. Geological Survey, 8711 37th Street SE, Jamestown, North Dakota 58401; telephone: 701- 253-5539; fax: 701-253-5553; e-mail: Douglas_H_Johnson@usgs.gov.

  17. Surface charge engineering of a Bacillus gibsonii subtilisin protease.

    PubMed

    Jakob, Felix; Martinez, Ronny; Mandawe, John; Hellmuth, Hendrik; Siegert, Petra; Maurer, Karl-Heinz; Schwaneberg, Ulrich

    2013-08-01

    In proteins, a posttranslational deamidation process converts asparagine (Asn) and glutamine (Gln) residues into negatively charged aspartic (Asp) and glutamic acid (Glu), respectively. This process changes the protein net charge affecting enzyme activity, pH optimum, and stability. Understanding the principles which affect these enzyme properties would be valuable for protein engineering in general. In this work, three criteria for selecting amino acid substitutions of the deamidation type in the Bacillus gibsonii alkaline protease (BgAP) are proposed and systematically studied in their influence on pH-dependent activity and thermal resistance. Out of 113 possible surface amino acids, 18 (11 Asn and 7 Gln) residues of BgAP were selected and evaluated based on three proposed criteria: (1) The Asn or Gln residues should not be conserved, (2) should be surface exposed, and (3) neighbored by glycine. "Deamidation" in five (N97, N253, Q37, Q200, and Q256) out of eight (N97, N154, N250, N253, Q37, Q107, Q200, and Q256) amino acids meeting all criteria resulted in increased proteolytic activity. In addition, pH activity profiles of the variants N253D and Q256E and the combined variant N253DQ256E were dramatically shifted towards higher activity at lower pH (range of 8.5-10). Variant N253DQ256E showed twice the specific activity of wild-type BgAP and its thermal resistance increased by 2.4 °C at pH 8.5. These property changes suggest that mimicking surface deamidation by substituting Gln by Glu and/or Asn by Asp might be a simple and fast protein reengineering approach for modulating enzyme properties such as activity, pH optimum, and thermal resistance.

  18. Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma.

    PubMed

    Fujiwara, Tomohiro; Uotani, Koji; Yoshida, Aki; Morita, Takuya; Nezu, Yutaka; Kobayashi, Eisuke; Yoshida, Akihiko; Uehara, Takenori; Omori, Toshinori; Sugiu, Kazuhisa; Komatsubara, Tadashi; Takeda, Ken; Kunisada, Toshiyuki; Kawamura, Machiko; Kawai, Akira; Ochiya, Takahiro; Ozaki, Toshifumi

    2017-05-16

    Emerging evidence has suggested that circulating microRNAs (miRNAs) in body fluids have novel diagnostic and prognostic significance for patients with malignant diseases. The lack of useful biomarkers is a crucial problem of bone and soft tissue sarcomas; therefore, we investigated the circulating miRNA signature and its clinical relevance in osteosarcoma. Global miRNA profiling was performed using patient serum collected from a discovery cohort of osteosarcoma patients and controls and cell culture media. The secretion of the detected miRNAs from osteosarcoma cells and clinical relevance of serum miRNA levels were evaluated using in vitro and in vivo models and a validation patient cohort. Discovery screening identified 236 serum miRNAs that were highly expressed in osteosarcoma patients compared with controls, and eight among these were also identified in the cell culture media. Upregulated expression levels of miR-17-5p and miR-25-3p were identified in osteosarcoma cells, and these were abundantly secreted into the culture media in tumor-derived exosomes. Serum miR-25-3p levels were significantly higher in osteosarcoma patients than in control individuals in the validation cohort, with favorable sensitivity and specificity compared with serum alkaline phosphatase. Furthermore, serum miR-25-3p levels at diagnosis were correlated with patient prognosis and reflected tumor burden in both in vivo models and patients; these associations were more sensitive than those of serum alkaline phosphatase. Serum-based circulating miR-25-3p may serve as a non-invasive blood-based biomarker for tumor monitoring and prognostic prediction in osteosarcoma patients.

  19. Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma

    PubMed Central

    Fujiwara, Tomohiro; Uotani, Koji; Yoshida, Aki; Morita, Takuya; Nezu, Yutaka; Kobayashi, Eisuke; Yoshida, Akihiko; Uehara, Takenori; Omori, Toshinori; Sugiu, Kazuhisa; Komatsubara, Tadashi; Takeda, Ken; Kunisada, Toshiyuki; Kawamura, Machiko; Kawai, Akira; Ochiya, Takahiro; Ozaki, Toshifumi

    2017-01-01

    Background Emerging evidence has suggested that circulating microRNAs (miRNAs) in body fluids have novel diagnostic and prognostic significance for patients with malignant diseases. The lack of useful biomarkers is a crucial problem of bone and soft tissue sarcomas; therefore, we investigated the circulating miRNA signature and its clinical relevance in osteosarcoma. Methods Global miRNA profiling was performed using patient serum collected from a discovery cohort of osteosarcoma patients and controls and cell culture media. The secretion of the detected miRNAs from osteosarcoma cells and clinical relevance of serum miRNA levels were evaluated using in vitro and in vivo models and a validation patient cohort. Results Discovery screening identified 236 serum miRNAs that were highly expressed in osteosarcoma patients compared with controls, and eight among these were also identified in the cell culture media. Upregulated expression levels of miR-17-5p and miR-25-3p were identified in osteosarcoma cells, and these were abundantly secreted into the culture media in tumor-derived exosomes. Serum miR-25-3p levels were significantly higher in osteosarcoma patients than in control individuals in the validation cohort, with favorable sensitivity and specificity compared with serum alkaline phosphatase. Furthermore, serum miR-25-3p levels at diagnosis were correlated with patient prognosis and reflected tumor burden in both in vivo models and patients; these associations were more sensitive than those of serum alkaline phosphatase. Conclusions Serum-based circulating miR-25-3p may serve as a non-invasive blood-based biomarker for tumor monitoring and prognostic prediction in osteosarcoma patients. PMID:28380419

  20. Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome

    PubMed Central

    Luo, Fengtao; Xie, Yangli; Xu, Wei; Huang, Junlan; Zhou, Siru; Wang, Zuqiang; Luo, Xiaoqing; Liu, Mi; Chen, Lin; Du, Xiaolan

    2017-01-01

    Apert syndrome (AS) is a common genetic syndrome in humans characterized with craniosynostosis. Apert patients and mouse models showed abnormalities in sutures, cranial base and brain, that may all be involved in the pathogenesis of skull malformation of Apert syndrome. To distinguish the differential roles of these components of head in the pathogenesis of the abnormal skull morphology of AS, we generated mouse strains specifically expressing mutant FGFR2 in chondrocytes, osteoblasts, and progenitor cells of central nervous system (CNS) by crossing Fgfr2+/P253R-Neo mice with Col2a1-Cre, Osteocalcin-Cre (OC-Cre), and Nestin-Cre mice, respectively. We then quantitatively analyzed the skull and brain morphology of these mutant mice by micro-CT and micro-MRI using Euclidean distance matrix analysis (EDMA). Skulls of Col2a1-Fgfr2+/P253R mice showed Apert syndrome-like dysmorphology, such as shortened skull dimensions along the rostrocaudal axis, shortened nasal bone, and evidently advanced ossification of cranial base synchondroses. The OC-Fgfr2+/P253R mice showed malformation in face at 8-week stage. Nestin-Fgfr2+/P253R mice exhibited increased dorsoventral height and rostrocaudal length on the caudal skull and brain at 8 weeks. Our study indicates that the abnormal skull morphology of AS is caused by the combined effects of the maldevelopment in calvarias, cranial base, and brain tissue. These findings further deepen our knowledge about the pathogenesis of the abnormal skull morphology of AS, and provide new clues for the further analyses of skull phenotypes and clinical management of AS. PMID:28123344

  1. Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome.

    PubMed

    Luo, Fengtao; Xie, Yangli; Xu, Wei; Huang, Junlan; Zhou, Siru; Wang, Zuqiang; Luo, Xiaoqing; Liu, Mi; Chen, Lin; Du, Xiaolan

    2017-01-01

    Apert syndrome (AS) is a common genetic syndrome in humans characterized with craniosynostosis. Apert patients and mouse models showed abnormalities in sutures, cranial base and brain, that may all be involved in the pathogenesis of skull malformation of Apert syndrome. To distinguish the differential roles of these components of head in the pathogenesis of the abnormal skull morphology of AS, we generated mouse strains specifically expressing mutant FGFR2 in chondrocytes, osteoblasts, and progenitor cells of central nervous system (CNS) by crossing Fgfr2 +/P253R-Neo mice with Col2a1-Cre, Osteocalcin-Cre (OC-Cre), and Nestin-Cre mice, respectively. We then quantitatively analyzed the skull and brain morphology of these mutant mice by micro-CT and micro-MRI using Euclidean distance matrix analysis (EDMA). Skulls of Col2a1-Fgfr2 +/P253R mice showed Apert syndrome-like dysmorphology, such as shortened skull dimensions along the rostrocaudal axis, shortened nasal bone, and evidently advanced ossification of cranial base synchondroses. The OC-Fgfr2 +/P253R mice showed malformation in face at 8-week stage. Nestin-Fgfr2 +/P253R mice exhibited increased dorsoventral height and rostrocaudal length on the caudal skull and brain at 8 weeks. Our study indicates that the abnormal skull morphology of AS is caused by the combined effects of the maldevelopment in calvarias, cranial base, and brain tissue. These findings further deepen our knowledge about the pathogenesis of the abnormal skull morphology of AS, and provide new clues for the further analyses of skull phenotypes and clinical management of AS.

  2. An Exponential Stability Result of a Timoshenko System with Thermoelasticity with Second Sound and in the Presence of Delay

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Apalara, Tijani A., E-mail: tijani@kfupm.edu.sa; Messaoudi, Salim A., E-mail: messaoud@kfupm.edu.sa

    In this paper, we consider a one-dimensional linear thermoelastic system of Timoshenko type with a delay, where the heat flux is given by Cattaneo’s law. We prove an exponential decay result under a smallness condition on the delay and a stability number introduced first in Santos et al. (J Diff Eqs 253:2715–2733, 2012), using a method different from that of Santos et al. (J Diff Eqs 253:2715–2733, 2012). We also reproduce the polynomial decay of Santos et al. (J Diff Eqs 253:2715–2733, 2012) using the multiplier method in the case of absence of delay. The polynomial decay issue in themore » presence of a small delay is an open question.« less

  3. Optical control of insulin release using a photoswitchable sulfonylurea.

    PubMed

    Broichhagen, Johannes; Schönberger, Matthias; Cork, Simon C; Frank, James A; Marchetti, Piero; Bugliani, Marco; Shapiro, A M James; Trapp, Stefan; Rutter, Guy A; Hodson, David J; Trauner, Dirk

    2014-10-14

    Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost insulin release from the pancreatic beta cell mass to restore glucose homeostasis. A limitation of these compounds is the elevated risk of developing hypoglycemia and cardiovascular disease, both potentially fatal complications. Here, we describe the design and development of a photoswitchable sulfonylurea, JB253, which reversibly and repeatedly blocks KATP channel activity following exposure to violet-blue light. Using in situ imaging and hormone assays, we further show that JB253 bestows light sensitivity upon rodent and human pancreatic beta cell function. Thus, JB253 enables the optical control of insulin release and may offer a valuable research tool for the interrogation of KATP channel function in health and T2DM.

  4. Comment on "Applications of homogenous balanced principle on investigating exact solutions to a series of time fractional nonlinear PDEs", [Commun Nonlinear Sci Numer Simulat 47 (2017) 253-266

    NASA Astrophysics Data System (ADS)

    Li, Xiangzheng

    2018-06-01

    A counterexample is given to show that the product rule of the Caputo fractional derivatives does not hold except on a special point. The function-expansion method of separation variable proposed by Rui[Commun Nonlinear Sci Numer Simulat 47 (2017) 253-266] based on the product rule must be modified.

  5. Effects of management practices on grassland birds: Eastern Meadowlark

    USGS Publications Warehouse

    Hull, Scott D.

    2000-01-01

    This report has been downloaded from the Northern Prairie Wildlife Research Center WorldWide Web site, www.npwrc.usgs.gov/resource/literatr/grasbird/grasbird.htm. Please direct comments and suggestions to Douglas H. Johnson, Northern Prairie Wildlife Research Center, U.S. Geological Survey, 8711 37th Street SE, Jamestown, North Dakota 58401; telephone: 701- 253-5539; fax: 701-253-5553; e-mail: Douglas_H_Johnson@usgs.gov.

  6. 77 FR 10669 - Fisheries of the Exclusive Economic Zone Off Alaska; Bering Sea and Aleutian Islands; Final 2012...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... data that were available at the Council's December meeting, NMFS is implementing the final 2012 and... available (see ADDRESSES). From these data and analyses, the Plan Team estimated an OFL and ABC for each... proposed TAC from proposed Pollock BS 1,200,000 1,253,658 -53,658 1,201,900 1,253,658 -51,758 AI 19,000 19...

  7. 50 CFR 85.21 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... May 1 of the year preceding that fiscal year (e.g., May 1, 1995 for FY 1996). [59 FR 11206, Mar. 10... fish restoration fax number 1 503-231-6128 503-231-6996 2 505-248-7465 505-248-7471 3 612-713-5130 612-713-5290 4 404-679-4159 404-679-4160 5 413-253-8508 413-253-8487 6 303-236-4411 303-236-8192 7 907-786...

  8. 50 CFR 85.21 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... May 1 of the year preceding that fiscal year (e.g., May 1, 1995 for FY 1996). [59 FR 11206, Mar. 10... fish restoration fax number 1 503-231-6128 503-231-6996 2 505-248-7465 505-248-7471 3 612-713-5130 612-713-5290 4 404-679-4159 404-679-4160 5 413-253-8508 413-253-8487 6 303-236-4411 303-236-8192 7 907-786...

  9. Effects of management practices on wetland birds: Marsh Wren

    USGS Publications Warehouse

    Zimmerman, Amy L.; Dechant, Jill A.; Johnson, Douglas H.; Goldade, Christopher M.; Church, James O.; Euliss, Betty R.

    2002-01-01

    This report has been downloaded from the Northern Prairie Wildlife Research Center WorldWide Web site, www.npwrc.usgs.gov/resource/literatr/grasbird/grasbird.htm. Please direct comments and suggestions to Douglas H. Johnson, Northern Prairie Wildlife Research Center, U.S. Geological Survey, 8711 37th Street SE, Jamestown, North Dakota 58401; telephone: 701- 253-5539; fax: 701-253-5553; e-mail: Douglas_H_Johnson@usgs.gov.

  10. Effects of management practices on grassland birds: Wilson's Phalarope

    USGS Publications Warehouse

    Dechant, Jill A.; Johnson, Douglas H.; Igl, Lawrence D.; Goldade, Christopher M.; Zimmerman, Amy L.; Euliss, Betty R.

    1999-01-01

    This report has been downloaded from the Northern Prairie Wildlife Research Center WorldWide Web site, www.npwrc.usgs.gov/resource/literatr/grasbird/grasbird.htm. Please direct comments and suggestions to Douglas H. Johnson, Northern Prairie Wildlife Research Center, U.S. Geological Survey, 8711 37th Street SE, Jamestown, North Dakota 58401; telephone: 701- 253-5539; fax: 701-253-5553; e-mail: Douglas_H_Johnson@usgs.gov.

  11. Effects of management practices on wetland birds: Eared Grebe

    USGS Publications Warehouse

    Dechant, Jill A.; Johnson, Douglas H.; Goldade, Christopher M.; Church, James O.; Euliss, Betty R.

    2002-01-01

    This report has been downloaded from the Northern Prairie Wildlife Research Center WorldWide Web site, www.npwrc.usgs.gov/resource/literatr/wetbird/wetbird.htm. Please direct comments and suggestions to Douglas H. Johnson, Northern Prairie Wildlife Research Center, U.S. Geological Survey, 8711 37th Street SE, Jamestown, North Dakota 58401; telephone: 701- 253-5539; fax: 701-253-5553; e-mail: Douglas_H_Johnson@usgs.gov

  12. DDN (Defence Data Network) Protocol Implementations and Vendors Guide

    DTIC Science & Technology

    1988-08-01

    Artificial Intelligence Laboratory Room NE43-723 545 Technology Square Cambridge, MA 02139 (617) 253-8843 S John Wroclawski, (JTW@AI.AJ.MIT.EDU...Massachusetts Institute of Technology Artificial Intelligence Laboratory Room NE43-743 545 Technology Square 0 Cambridge, MA 02139 (617) 253-7885 ORDERING...TCP/IP Network Software for PC-DOS Systems CPU: IBM-PC/XT/AT/compatible in conjunction with EXOS 205 Inteligent Ethernet Controller for PCbus 0/s

  13. [Microbiological study of male genital ulcers. Apropos of 75 cases].

    PubMed

    Casin, I; Bianchi, A; Ramel, F; Lajoie, C; Chastang, C; Scieux, C; Ferchal, F; Janier, M; Morel, P; Perol, Y

    1990-09-01

    Between November 1986 and June 1987, the microbial aetiology of genital ulcers was assessed in 75 male patients attending the Sexually Transmitted Disease (STD) clinic in Hôpital Saint-Louis, Paris. Evidence of Haemophilus ducreyi was found in 18 patients (24%), Herpes simplex virus in 19 (25.3%). Syphilis was diagnosed on the basis of dark field microscopy and/or positive serology test in 19 patients (25.3%). Lymphogranuloma venereum was not diagnosed in any patient. Primary pathogens were not identified from the remaining 19 (25.3%) men. Neisseria gonorrhoea was isolated in five patients, from the ulcer in three cases, from the urethra in two. Asymptomatic urethral carriage of Chlamydia trachomatis was culture proven in seven cases. The presence of IgM antibodies to C. trachomatis at a titre greater than 40 found in 17 patients was a indication of a current chlamydial infection. Three patients (4%) were discovered to be HIV-1 positive.

  14. Critical Problems in Very Large Scale Computer Systems

    DTIC Science & Technology

    1990-09-30

    Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Anant Agarwal (617) 253-1448 William J. Dally (617) 253-6043 Srinivas Devadas ...Contrac t No. N00014-87-K-0825. Srinivs Devada (67 5305 F.pproved f r Public rgt (1 236 Ditribution Unlimited (7 5 8 Contents 1 Research Overview 2...d/or Dist Special I 1 Research Overview • The research vehicle for this contract i/the largest possible computerthat ’ can b conceived for the mid to

  15. WEBTAS Software Life Cycle Development

    DTIC Science & Technology

    2006-09-01

    may be published in both html and pdf formats via menu selection. Adobe® FrameMaker ® 7.1 and Quadralay Corporation WebWorks® Professional 2003...X X WebTAS 2.5.3 ISAM X X WebTAS 2.5.3 Domain Editor Guide X X 13 The backbone of the ISS publishing environment consists of Adobe® FrameMaker ...and WebWorks® Publisher Professional 2003. FrameMaker ® provides an enterprise-class authoring and publishing solution that combines the

  16. Temperature dependence of the ozone absorption cross section at the 253.7-nm mercury line

    NASA Technical Reports Server (NTRS)

    Barnes, J.; Mauersberger, K.

    1987-01-01

    The temperature dependence of the ozone absorption cross section at 253.7 nm has been measured between 195 and 351 K. The experimental technique employed circumvents the necessity to determine the absolute ozone concentration for each temperature measurement. Below 273 K the cross section increases approximately 0.6 percent, while toward higher temperatures the cross section decreases rapidly. In a comparison, good agreement with other recently made measurements is shown.

  17. Dynamic temperature fields under Mars landing sites and implications for supporting microbial life.

    PubMed

    Ulrich, Richard; Kral, Tim; Chevrier, Vincent; Pilgrim, Robert; Roe, Larry

    2010-01-01

    While average temperatures on Mars may be too low to support terrestrial life-forms or aqueous liquids, diurnal peak temperatures over most of the planet can be high enough to provide for both, down to a few centimeters beneath the surface for some fraction of the time. A thermal model was applied to the Viking 1, Viking 2, Pathfinder, Spirit, and Opportunity landing sites to demonstrate the dynamic temperature fields under the surface at these well-characterized locations. A benchmark temperature of 253 K was used as a lower limit for possible metabolic activity, which corresponds to the minimum found for specific terrestrial microorganisms. Aqueous solutions of salts known to exist on Mars can provide liquid solutions well below this temperature. Thermal modeling has shown that 253 K is reached beneath the surface at diurnal peak heating for at least some parts of the year at each of these landing sites. Within 40 degrees of the equator, 253 K beneath the surface should occur for at least some fraction of the year; and, within 20 degrees , it will be seen for most of the year. However, any life-form that requires this temperature to thrive must also endure daily excursions to far colder temperatures as well as periods of the year where 253 K is never reached at all.

  18. Microstructures and Mechanical Properties of Inconel 718 Alloy at Ultralow Temperatures

    NASA Astrophysics Data System (ADS)

    Yao, C. G.; Lv, H. J.; Yi, D. Q.; Meng, S.; Xiao, L. R.; Wang, B.

    2018-04-01

    The microstructures and mechanical properties of powder metallurgy Inconel 718 alloy were investigated in the temperatures range between 25 and - 253 °C. Tensile strength increased with the decrease in temperature, while the ductility first increased and then decreased. There was no significant change in impact toughness. When the temperature was - 253 °C, a zigzag stress-strain curve was observed for the alloy, owing to the interaction of dislocation glide and twinning, which effectively maintained the relatively good ductility.

  19. Microstructures and Mechanical Properties of Inconel 718 Alloy at Ultralow Temperatures

    NASA Astrophysics Data System (ADS)

    Yao, C. G.; Lv, H. J.; Yi, D. Q.; Meng, S.; Xiao, L. R.; Wang, B.

    2018-05-01

    The microstructures and mechanical properties of powder metallurgy Inconel 718 alloy were investigated in the temperatures range between 25 and - 253 °C. Tensile strength increased with the decrease in temperature, while the ductility first increased and then decreased. There was no significant change in impact toughness. When the temperature was - 253 °C, a zigzag stress-strain curve was observed for the alloy, owing to the interaction of dislocation glide and twinning, which effectively maintained the relatively good ductility.

  20. National Program for Inspection of Non-Federal Dams. Chase Pond Dam (NH 00255), NHWRB Number 253.02, Merrimack River Basin, Wilmot, New Hampshire. Phase I Inspection Report.

    DTIC Science & Technology

    1980-03-01

    STANDAROS-1963-A L ~.°.. o...... 1....MERRIMACK RIVER BASIN -!. WILMOT , NEW HAMPSHIRE ’,- CHASE POND DAM NH 00255 NHWRB NO. 253.02 r PHASE I...Continue on fewsorsp side #0 .o..oemay and Ientify by black Muthot) - DAMS, NSPECTION, PAM S’AFETY, Merrimack River Basin. * Wilmot , New Hampshire...MERRIMACK RIVER BASIN R WILMOT , NEW HAMPSHIRE - - PHASE I INSPECTION REPORT NATIONAL DAM INSPECTION PROGRAM :: : I

  1. A Dynamically Configurable Log-based Distributed Security Event Detection Methodology using Simple Event Correlator

    DTIC Science & Technology

    2010-06-01

    shadow |\\/ etc\\/ passwd |cmd... \\.exe .*?)\\s.*\\s\\".*\\" desc=$0 action=shellcmd /home/user/sec -2.5.3/ common/syslogclient "... Synthetic : " "$2|$1...etc\\/ shadow |\\/ etc\\/ passwd |cmd... \\.exe .*?)\\s.*\\s\\".*\\" desc=$0 context =[ HYBRID_LOGGING] action=shellcmd /home/user/sec -2.5.3/ common...suspicious filenames type=Single continue=TakeNext ptype=RegExp pattern =(.*)\\s(.*)\\s.*(\\/ etc\\/ shadow |\\/ etc\\/ passwd |cmd\\.exe .*?)\\s... .*\\s(.*)\\s.*\\s

  2. The Single Kinin Receptor Signals to Separate and Independent Physiological Pathways in Malpighian Tubules of the Yellow Fever Mosquito

    DTIC Science & Technology

    2010-06-10

    Felix Tiburcy3, Ronald J. Nachman4, Peter M. Piermarini1 and Klaus W. Beyenbach1 1Department of Biomedical Sciences, VRT 8004, Cornell...Dept. of Biomedical Sciences VRT 8004 Cornell University Ithaca, NY 14853 Voice: (607) 253-3482 FAX: (607) 253-3851 Email: KWB1@CORNELL.EDU...University,Department of Biomedical Sciences, VRT 8004,Ithaca,NY,14853 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND

  3. DISCOVERY OF A NEW FAINT DWARF GALAXY ASSOCIATED WITH NGC 253

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sand, D. J.; Crnojević, D.; Strader, J.

    2014-09-20

    We report the discovery of a new faint dwarf galaxy, which we dub Scl-MM-Dw1, at a projected distance of ∼65 kpc from the spiral galaxy NGC 253. The discovery results from the Panoramic Imaging Survey of Centaurus and Sculptor (PISCeS), a program with the Magellan/Megacam imager to study faint substructure in resolved stellar light around massive galaxies outside of the Local Group. We measure a tip of the red giant branch distance to Scl-MM-Dw1 of D = 3.9 ± 0.5 Mpc, consistent with that of NGC 253, making their association likely. The new dwarf's stellar population is complex, with an old, metal-poor red giant branch (≳10 Gyr, [Fe/H] ∼ –2), andmore » an asymptotic giant branch with an age of ∼500 Myr. Scl-MM-Dw1 has a half-light radius of r{sub h} = 340 ± 50 pc and an absolute magnitude of M{sub V}  = –10.3 ± 0.6 mag, comparable to the Milky Way's satellites at the same luminosity. Once complete, our imaging survey of NGC 253 and other nearby massive galaxies will provide a census of faint substructure in halos beyond the Local Group, both to put our own environment into context and to confront models of hierarchical structure formation.« less

  4. Postnatal brain and skull growth in an Apert syndrome mouse model

    PubMed Central

    Hill, Cheryl A.; Martínez-Abadías, Neus; Motch, Susan M.; Austin, Jordan R.; Wang, Yingli; Jabs, Ethylin Wang; Richtsmeier, Joan T.; Aldridge, Kristina

    2012-01-01

    Craniofacial and neural tissues develop in concert throughout pre- and postnatal growth. FGFR-related craniosynostosis syndromes, such as Apert syndrome (AS), are associated with specific phenotypes involving both the skull and the brain. We analyzed the effects of the FGFR P253R mutation for Apert syndrome using the Fgfr2+/P253R mouse to evaluate the effects of this mutation on these two tissues over the course of development from day of birth (P0) to postnatal day 2 (P2). Three-dimensional magnetic resonance microscopy and computed tomography images were acquired from Fgfr2+/P253R mice and unaffected littermates at P0 (N=28) and P2 (N=23). 3D coordinate data for 23 skull and 15 brain landmarks were statistically compared between groups. Results demonstrate that the Fgfr2+/P253R mice show reduced growth in the facial skeleton and the cerebrum, while the height and width of the neurocranium and caudal regions of the brain show increased growth relative to unaffected littermates. This localized correspondence of differential growth patterns in skull and brain point to their continued interaction through development and suggest that both tissues display divergent postnatal growth patterns relative to unaffected littermates. However, the change in the skull-brain relationship from P0 to P2 implies that each tissue affected by the mutation retains a degree of independence, rather than one tissue directing the development of the other. PMID:23495236

  5. Effects of Lateral Heterogeneities on the Propagation, Scattering, and Attenuation of the Seismic Waves and the Characterization of the Seismic Source

    DTIC Science & Technology

    1983-09-30

    investigators - Keiiti Aki, 617/253-6397 u M. Nafi Toksoz, 617/253-6382 Program Manager - William J. Best, 202/767-4908 Short Title of Work - Effects...Distribution Is unlimited. MATTHEW J. ICEfRM SUIMARYChief, tehnial Inforstion 91vilon The work preeated i-n this tl=c’-repO, illustrates results obtained...of such models are those by Ben Menahem [19611, Haskell [19641, Savage 119661, Molnar et al. [19731, Sato and Hirasawa [1973), and Dahlen [1974). The

  6. Erratum to "Solar Sources and Geospace Consequences of Interplanetary Magnetic Clouds Observed During Solar Cycle 23-Paper 1" [J. Atmos. Sol.-Terr. Phys. 70(2-4) (2008) 245-253

    NASA Technical Reports Server (NTRS)

    Gopalswamy, N.; Akiyama, S.; Yashiro, S.; Michalek, G.; Lepping, R. P.

    2009-01-01

    One of the figures (Fig. 4) in "Solar sources and geospace consequences of interplanetary magnetic Clouds observed during solar cycle 23 -- Paper 1" by Gopalswamy et al. (2008, JASTP, Vol. 70, Issues 2-4, February 2008, pp. 245-253) is incorrect because of a software error in t he routine that was used to make the plot. The source positions of various magnetic cloud (MC) types are therefore not plotted correctly.

  7. Kinetics of the reaction of Cl atoms with CHCl 3 over the temperature range 253-313 K

    NASA Astrophysics Data System (ADS)

    Nilsson, Elna J. K.; Hoff, Janus; Nielsen, Ole John; Johnson, Matthew S.

    2010-07-01

    The reaction CHCl 3 + Cl → CCl 3 + HCl was studied in the atmospherically relevant temperature range from 253 to 313 K and in 930 mbar of N 2 diluent using the relative rate method. A temperature dependent reaction rate constant, valid in the temperature range 220-330 K, was determined by a fit to the result of the present study and that of Orlando (1999); k = (3.77 ± 0.32) × 10 -12 exp((-1011 ± 24)/T) cm 3 molecule -1 s -1.

  8. New Engineering & Development Initiatives -- Policy and Technology Choices: Consensus Views of User/Aviation Industry Representatives. Volume I.

    DTIC Science & Technology

    1979-03-01

    253 7.2 Enhancing MLS or ATARS 253 7.3 Weather Information 254 7.4 Other Safety Benefits 254 7.5 Human Factors 255 8.0 Pilot Training 256 8.1...Service (D)ABS/ ATARS ) in the terminal environment, what are the capacity/noise relation- ships under the new noise regulations at key hub airports, etc...whether manual or automatic, must be maintained at least during the DABS transition period and perhaps thereafter. Together with DABS/ ATARS the en

  9. AKARI Near-infrared Spectroscopic Observations of Interstellar Ices in the Edge-on Starburst Galaxy NGC 253

    NASA Astrophysics Data System (ADS)

    Yamagishi, Mitsuyoshi; Kaneda, Hidehiro; Ishihara, Daisuke; Oyabu, Shinki; Onaka, Takashi; Shimonishi, Takashi; Suzuki, Toyoaki

    2011-04-01

    We present the spatially resolved near-infrared (2.5-5.0 μm) spectra of the edge-on starburst galaxy NGC 253 obtained with the Infrared Camera on board AKARI. Near the center of the galaxy, we clearly detect the absorption features of interstellar ices (H2O: 3.05 μm, CO2: 4.27 μm, and XCN: 4.62 μm) and the emission of polycyclic aromatic hydrocarbons (PAHs) at 3.29 μm and the hydrogen recombination line Brα at 4.05 μm. We find that the distributions of the ices differ from those of the PAH and gas. We calculate the column densities of the ices and derive the abundance ratios of N(CO2)/N(H2O) = 0.17 ± 0.05. They are similar to those obtained around the massive young stellar objects in our Galaxy (0.17 ± 0.03), although a much stronger interstellar radiation field and higher dust temperature are expected near the center of NGC 253.

  10. The infrared counterpart of the eclipsing X-ray binary HO253 + 193

    NASA Technical Reports Server (NTRS)

    Zuckerman, B.; Becklin, E. E.; Mclean, I. S.; Patterson, Joseph

    1992-01-01

    We report the identification of the infrared counterpart of the pulsating X-ray source HO253 + 193. It is a highly reddened star varying in K light with a period near 3 hr, but an apparent even-odd effect in the light curve implies that the true period is 6.06 hr. Together with the recent report of X-ray eclipses at the latter period, this establishes the close binary nature of the source. Infrared minimum occurs at X-ray minimum, certifying that the infrared variability arises from the tidal distortion of the lobe-filling secondary. The absence of a point source at radio wavelengths, plus the distance derived from the infrared data, suggests that the binary system is accidentally located behind the dense core of the molecular cloud Lynds 1457. The eclipses and pulsations in the X-ray light curve, coupled with the hard X-ray spectrum and low luminosity, demonstrate that HO253 + 193 contains an accreting magnetic white dwarf, and hence belongs to the 'DQ Herculis' class of cataclysmic variables.

  11. Prenatal diagnosis of de novo t(2;18;14)(q33.1;q12.2;q31.2), dup(5)(q34q34), del(7)(p21.1p21.1), and del(10)(q25.3q25.3) and a review of the prenatally ascertained de novo apparently balanced complex and multiple chromosomal rearrangements.

    PubMed

    Chen, Chih-Ping; Chern, Schu-Rern; Lee, Chen-Chi; Lin, Chyi-Chyang; Li, Yueh-Chun; Hsieh, Lie-Jiau; Chen, Wen-Lin; Wang, Wayseen

    2006-02-01

    To present the prenatal diagnosis of a de novo complex chromosomal rearrangement (CCR) associated with de novo interstitial deletions and duplication and to review the literature. Amniocentesis was performed at 18 weeks' gestation because of an increased risk for Down syndrome based on maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening. Amniocentesis revealed a karyotype of 46,XY,t(2;18;14)(q33.1;q12.2;q31.2),dup(5)(q34q34),del(7)(p21.1p21.1), del(10)(q25.3q25.3). The parental karyotypes were normal. The pregnancy was terminated. The fetus manifested facial dysmorphism, clinodactyly of both hands, and hypoplasia of the left great toe. Spectral karyotyping (SKY), cytogenetic polymorphism, and polymorphic DNA markers were used to investigate the imbalances and the origin of the de novo aberrant chromosomes. SKY showed a three-way CCR. Cytogenetic polymorphism investigation of the derivative chromosome 14 of the fetus and the parental chromosomes 14 determined the maternal origin of the translocation. Polymorphic DNA marker analysis confirmed the maternal origin of the de novo interstitial deletions and duplication. No cryptic imbalance at or near the breakpoints of the CCR was detected by the molecular analysis. De novo apparently balanced CCRs may be associated with imbalances in other chromosomes. We suggest further investigation and re-evaluation of cryptic or subtle imbalances in all cases classified as de novo apparently balanced CCRs. Copyright 2006 John Wiley & Sons, Ltd.

  12. Multi-epoch very long baseline interferometric observations of the nuclear starburst region of NGC 253: Improved modeling of the supernova and star formation rates

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rampadarath, H.; Morgan, J. S.; Tingay, S. J.

    2014-01-01

    The results of multi-epoch observations of the southern starburst galaxy, NGC 253, with the Australian Long Baseline Array at 2.3 GHz are presented. As with previous radio interferometric observations of this galaxy, no new sources were discovered. By combining the results of this survey with Very Large Array observations at higher frequencies from the literature, spectra were derived and a free-free absorption model was fitted of 20 known sources in NGC 253. The results were found to be consistent with previous studies. The supernova remnant, 5.48-43.3, was imaged with the highest sensitivity and resolution to date, revealing a two-lobed morphology.more » Comparisons with previous observations of similar resolution give an upper limit of 10{sup 4} km s{sup –1} for the expansion speed of this remnant. We derive a supernova rate of <0.2 yr{sup –1} for the inner 300 pc using a model that improves on previous methods by incorporating an improved radio supernova peak luminosity distribution and by making use of multi-wavelength radio data spanning 21 yr. A star formation rate of SFR(M ≥ 5 M {sub ☉}) < 4.9 M {sub ☉} yr{sup –1} was also estimated using the standard relation between supernova and star formation rates. Our improved estimates of supernova and star formation rates are consistent with studies at other wavelengths. The results of our study point to the possible existence of a small population of undetected supernova remnants, suggesting a low rate of radio supernova production in NGC 253.« less

  13. Survey of Water and Ammonia in Nearby Galaxies (SWAN): Resolved Ammonia Thermometry and Water and Methanol Masers in IC 342, NGC 6946, and NGC 2146

    NASA Astrophysics Data System (ADS)

    Gorski, Mark; Ott, Jürgen; Rand, Richard; Meier, David S.; Momjian, Emmanuel; Schinnerer, Eva

    2018-04-01

    The Survey of Water and Ammonia in Nearby galaxies (SWAN) studies atomic and molecular species across the nuclei of four star-forming galaxies: NGC 253, IC 342, NGC 6946, and NGC 2146. As part of this survey, we present Karl G. Jansky Very Large Array molecular line observations of three galaxies: IC 342, NGC 6946, and NGC 2146. NGC 253 is covered in a previous paper. These galaxies were chosen to span an order of magnitude in star formation rates and to select a variety of galaxy types. We target the metastable transitions of ammonia NH3(1, 1) to (5, 5), the 22 GHz water (H2O) (616–523) transition, and the 36.1 GHz methanol (CH3OH) (4‑1–30) transition. We use the NH3 metastable lines to perform thermometry of the dense molecular gas. We show evidence for uniform heating across the central kiloparsec of IC 342 with two temperature components for the molecular gas, similar to NGC 253, of 27 and 308 K, and that the dense molecular gas in NGC 2146 has a temperature <86 K. We identify two new water masers in IC 342, and one new water maser in each of NGC 6946 and NGC 2146. The two galaxies NGC 253 and NGC 2146, with the most vigorous star formation, host H2O kilomasers. Lastly, we detect the first 36 GHz CH3OH masers in IC 342 and NGC 6946. For the four external galaxies the total CH3OH luminosity in each galaxy suggests a correlation with galactic star formation rate, whereas the morphology of the emission is similar to that of HNCO, a weak shock tracer.

  14. The ULX Population in the Starburst Galaxy NGC 253

    NASA Technical Reports Server (NTRS)

    Weaver, K. A.; Heckman, T. M.; Strickland, D. K.

    2004-01-01

    Optimism is mounting for the existence of intermediate mass black holes (IMBH), which occupy the mass spectrum somewhere between the stellar-mass and supermassive varieties. IMBH are naturally predicted by theoretical stellar and black hole evolution models, but the strong attention to them began only recently with the discovery of ultraluminous x-ray sources (ULX). If isotropic and accreting normally, ULX have luminosities tens to thousands of times greater than the Eddington luminosity of a neutron star or stellar-mass black hole. A standard interpretation of their x-ray flux implies that they are powered by IMBH. On the other hand, they may be stellar-mass black holes that are beamed or emit anisotropically. Therefore, the exact nature of ULX is highly controversial. ULX are common in starburst galaxies. At a distance of only 3 Mpc, NGC 253 is bright, nearby, and one of the best-studied starburst galaxies. Approximately 50 distinct x-ray point sources are detected in or near the plane of the galaxy. At least six of these are ULX, with luminosities greater than 10 times that expected for a stellar-mass, accreting compact object. We present new Chandra data from an 80 ksec observation of NGC 253 obtained in 2003 that provides high quality spectra of these sources. Comparing the 1999 and 2003 Chandra observations, the sources have varied significantly over the course of four years, with one of the ULX disappearing completely. The ULX spectra are similar to black-hole XRBs and at least one appears to possess an iron K line. We will discuss what insight these data provide for the nature of ULX in NGC 253 .

  15. No Evidence of Isomerism for the First Excited State of {sup 93}Rb

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miernik, K., E-mail: kmiernik@fuw.edu.pl; Gross, C.J.; Grzywacz, R.

    2014-06-15

    The 253.3–keV excited state located in {sup 93}Rb was studied at the Holifield Radioactive Ion Beam Facility in Oak Ridge. This state, described as isomeric in databases, was populated in the decay of {sup 93}Kr produced by proton–induced fission of {sup 238}U and isolated using the isotope separation on–line technique. We report that the 253.3–keV level does not reveal isomerism and the upper limit of the half-life from our measurement is 4 ns. Our findings are supported by previously reported results that were not taken into account in the latest nuclear databases.

  16. Physicochemical properties of binary solutions of propylene carbonate-acetonitrile in the range of 253.15-313.15 K

    NASA Astrophysics Data System (ADS)

    Tyunina, E. Yu.; Chekunova, M. D.

    2017-05-01

    The density, dynamic viscosity, and dielectric constant of propylene carbonate solutions with acetonitrile are measured over the composition of a mixed solvent at temperatures of 253.15, 273.15, 293.15, and 313.15 K. The molar volume, molar viscosity, and molar capacity of a mixture of propylene carbonate-acetonitrile and an excess amount of it are calculated. The effect the temperature and composition of the mixture have on the excess molar properties is discussed. A linear correlation is observed between the values of the molar fluidity, capacity, polarization, and molar volume of the studied system.

  17. HUBBLE PROBES THE VIOLENT BIRTH OF STARS IN GALAXY NGC 253 [Left

    NASA Technical Reports Server (NTRS)

    2002-01-01

    An image of the spiral galaxy NGC 253, taken with a ground-based telescope. The galaxy is located about 8 million light-years away in the constellation Sculptor. Credit: Jay Gallagher (University of Wisconsin-Madison), Alan Watson (Lowell Observatory, Flagstaff, AZ), and NASA [Right] This NASA Hubble Space Telescope image of the core of the nearest starburst spiral galaxy, NGC 253, reveals violent star formation within a region 1,000 light-years across. A starburst galaxy has an exceptionally high rate of star birth, first identified by its excess of infrared radiation from warm dust. Hubble's high resolution allows astronomers to quantify complex structures in the starburst core of the galaxy for the first time, including luminous star clusters, dust lanes which trace regions of dense gas and filaments of glowing gas. Hubble identifies several regions of intense star formation, which include a bright, super-compact star cluster. These observations confirm that stars are often born in dense clusters within starbursts, and that dense gas coexists with and obscures the starburst core. This image was taken with Hubble's Wide Field Planetary Camera 2 (in PC mode). Credit: Carnegie Institution of Washington

  18. VizieR Online Data Catalog: DIB 661.3nm in Cepheid spectra (Kashuba+, 2016)

    NASA Astrophysics Data System (ADS)

    Kashuba, S. V.; Andrievsky, S. M.; Chekhonadskikh, F. A.; Luck, R. E.; Kovtyukh, V. V.; Korotin, S. A.; Krelowski, J.; Galazutdinov, G. A.

    2017-11-01

    We used spectra of Northern hemisphere Cepheids obtained by REL - one of the co-authors of this paper, with the High Resolution Spectrograph of the Hobby-Eberly Telescope at the McDonald Observatory of the University of Texas at Austin (Texas, USA) with the resolving power of 30000, a typical signal-to-noise ratio of about 100, and wavelength range of 435-780nm. A total of 253 Cepheid spectra were used in the research. We performed an investigation of the 661.356 nm DIB profile in 253 spectra of 176 Cepheids. After removal of the blending YII line the EW of each DIB was calculated for each spectrum. (1 data file).

  19. Direct Evidence for Maser Emission from the 36.2 GHz Class I Transition of Methanol in NGC253

    NASA Astrophysics Data System (ADS)

    Chen, Xi; Ellingsen, Simon P.; Shen, Zhi-Qiang; McCarthy, Tiege P.; Zhong, Wei-Ye; Deng, Hui

    2018-04-01

    Observations made with the Jansky Very large Array (JVLA) at an angular resolution of ∼0.″1 have detected class I methanol maser emission from the 36.2 GHz transition toward the starburst galaxy NGC 253. The methanol emission is detected toward four sites which lie within the regions of extended methanol emission detected in previous lower angular resolution (a few arcseconds) observations. The peak flux densities of the detected compact components are in the range 3–9 mJy beam‑1. Combining the JVLA data with single-dish observations from the Shanghai Tianma Radio Telescope (TMRT) and previous interferometric observations with the Australia Telescope Compact Array (ATCA), we show that the 36.2 GHz class I methanol emission consists of both extended and compact structures, with typical scales of ∼6″ (0.1 kpc) and ∼0.″05 (1 pc), respectively. The strongest components have a brightness temperature of >103 K, much higher than the maximum kinetic temperature (∼100 K) of the thermal methanol emission from NGC 253. Therefore, these observations conclusively demonstrate for the first time the presence of maser emission from a class I methanol transition in an external galaxy.

  20. 7 CFR 1901.253 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., sites, buildings, structures, and objects, significant in American history, architecture, archeology... significance in American History, Architecture, Archeology, and the culture is present in districts, sites...

  1. 7 CFR 1901.253 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., sites, buildings, structures, and objects, significant in American history, architecture, archeology... significance in American History, Architecture, Archeology, and the culture is present in districts, sites...

  2. 7 CFR 1901.253 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., sites, buildings, structures, and objects, significant in American history, architecture, archeology... significance in American History, Architecture, Archeology, and the culture is present in districts, sites...

  3. 7 CFR 1901.253 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., sites, buildings, structures, and objects, significant in American history, architecture, archeology... significance in American History, Architecture, Archeology, and the culture is present in districts, sites...

  4. Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

    PubMed Central

    Meng, Y Gloria; Hoyte, Kwame; Lutman, Jeff; Lu, Yanmei; Iyer, Suhasini; DeForge, Laura E; Theil, Frank-Peter; Fielder, Paul J; Prabhu, Saileta

    2012-01-01

    The neonatal Fc receptor (FcRn) plays an important and well-known role in immunoglobulin G (IgG) catabolism; however, its role in the disposition of IgG after subcutaneous (SC) administration, including bioavailability, is relatively unknown. To examine the potential effect of FcRn on IgG SC bioavailability, we engineered three anti-amyloid β monoclonal antibody (mAb) reverse chimeric mouse IgG2a (mIgG2a) Fc variants (I253A.H435A, N434H and N434Y) with different binding affinities to mouse FcRn (mFcRn) and compared their SC bioavailability to that of the wild-type (WT) mAb in mice. Our results indicated that the SC bioavailability of mIgG2a was affected by mFcRn-binding affinity. Variant I253A.H435A, which did not bind to mFcRn at either pH 6.0 or pH 7.4, had the lowest bioavailability (41.8%). Variant N434Y, which had the greatest increase in binding affinity at both pH 6.0 and pH 7.4, had comparable bioavailability to the WT antibody (86.1% vs. 76.3%), whereas Variant N434H, which had modestly increased binding affinity at pH 6.0 to mFcRn and affinity comparable to the WT antibody at pH 7.4, had the highest bioavailability (94.7%). A semi-mechanism-based pharmacokinetic model, which described well the observed data with the WT antibody and variant I253A.H435A, is consistent with the hypothesis that the decreased bioavailability of variant I253A.H435A was due to loss of the FcRn-mediated protection from catabolism at the absorption site. Together, these data demonstrate that FcRn plays an important role in SC bioavailability of therapeutic IgG antibodies. PMID:22327433

  5. The 253-kb inversion and deep intronic mutations in UNC13D are present in North American patients with familial hemophagocytic lymphohistiocytosis 3.

    PubMed

    Qian, Yaping; Johnson, Judith A; Connor, Jessica A; Valencia, C Alexander; Barasa, Nathaniel; Schubert, Jeffery; Husami, Ammar; Kissell, Diane; Zhang, Ge; Weirauch, Matthew T; Filipovich, Alexandra H; Zhang, Kejian

    2014-06-01

    The mutations in UNC13D are responsible for familial hemophagocytic lymphohistiocytosis (FHL) type 3. A 253-kb inversion and two deep intronic mutations, c.118-308C > T and c.118-307G > A, in UNC13D were recently reported in European and Asian FHL3 patients. We sought to determine the prevalence of these three non-coding mutations in North American FHL patients and evaluate the significance of examining these new mutations in genetic testing. We performed DNA sequencing of UNC13D and targeted analysis of these three mutations in 1,709 North American patients with a suspected clinical diagnosis of hemophagocytic lymphohistiocytosis (HLH). The 253-kb inversion, intronic mutations c.118-308C > T and c.118-307G > A were found in 11, 15, and 4 patients, respectively, in which the genetic basis (bi-allelic mutations) explained 25 additional patients. Taken together with previously diagnosed FHL3 patients in our HLH patient registry, these three non-coding mutations were found in 31.6% (25/79) of the FHL3 patients. The 253-kb inversion, c.118-308C > T and c.118-307G > A accounted for 7.0%, 8.9%, and 1.3% of mutant alleles, respectively. Significantly, eight novel mutations in UNC13D are being reported in this study. To further evaluate the expression level of the newly reported intronic mutation c.118-307G > A, reverse transcription PCR and Western blot analysis revealed a significant reduction of both RNA and protein levels suggesting that the c.118-307G > A mutation affects transcription. These specified non-coding mutations were found in a significant number of North American patients and inclusion of them in mutation analysis will improve the molecular diagnosis of FHL3. © 2014 Wiley Periodicals, Inc.

  6. Experimental and theoretical investigation of temperature effects on an interbedded betavoltaic employing epitaxial Si and bidirectional (63)Ni.

    PubMed

    Liu, Yunpeng; Tang, Xiaobin; Xu, Zhiheng; Hong, Liang; Chen, Da

    2014-12-01

    The performance of an interbedded betavoltaic employing epitaxial Si and bidirectional (63)Ni was measured and calculated at various temperatures. The experimental results indicate that the temperature dependence of the performance of interbedded betavoltaics is similar to that of monolayer betavoltaics: Voc and Pmax decrease approximately linearly with increasing temperature at low temperatures of 213.15-253.15K and decrease exponentially with increasing temperature at high temperatures of 253.15-333.15K. However, the calculation results indicate that the temperature dependences of Voc and Pmax are always linear at both high and low temperatures. Isc increases slightly with increasing temperature in both experiment and calculation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Nuevos resultados sobre la cinemática global y nuclear de NGC 253: movimientos no circulares y emisión en Br γ

    NASA Astrophysics Data System (ADS)

    Camperi, J. A.; Gunthardt, G. I.; Díaz, R. J.; Agüuero, M. P.; Gimeno, G.; Pessev, P.

    Continuing with previous research (Camperi et al., BAAA, 54, 377, 2011), new heliocentric radial velocity distributions are presented for the nearby galaxy NGC 253, obtained from the ionized hydrogen recombination line Hα. These distributions have been derived from long-slit spectroscopy for various position angles. It is also shown the heliocentric radial velocity distribution corresponding to part of the infrared data (ionized hydrogen recombination line Brγ) observed with the Phoenix spectrograph of the Gemini South Observatory. Sequential mapping with the long slit using this instrument will enable to study in detail the kinematics of the galaxy's core, which is strongly obscured by dust. FULL TEXT IN SPANISH

  8. 50 CFR 253.20 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Conservation and Management Act (16 U.S.C. 1801 et seq.). Fisheries management means all activities concerned with conservation, restoration, enhancement, or utilization of fisheries resources, including research...

  9. XMM-Newton Observations of NGC 253: Resolving the Emission Components in the Disk and Nuclear Area

    NASA Technical Reports Server (NTRS)

    Pietsch, W.; Borozdin, K. N.; Branduardi-Raymont, G.; Cappi, M.; Ehle, M.; Ferrando, P.; Freyberg, M. J.; Kahn, S. M.; Ponman, T. J.; Ptak, A.

    2000-01-01

    We describe the first XMM-Newton observations of the starburst galaxy NGC 253. As known from previous X-ray observations, NGC 253 shows a mixture of extended (disk and halo) and point-source emission. The high XMM-Newton throughput allows for the first time a detailed investigation of the spatial, spectral and variability properties of these components simultaneously. We detect a bright X-ray transient approx. 70 sec SSW of the nucleus and show the spectrum and light curve of the brightest point source (approx. 30 sec S of the nucleus, most likely a black-hole X-ray binary, BHXRB). The unprecedented combination of RGS and EPIC also sheds new light on the emission of the complex nuclear region, the X-ray plume and the disk diffuse emission. In particular, EPIC images reveal that the limb-brightening of the plume is mostly seen in higher ionization emission lines, while in the lower ionization lines, and below 0.5 keV, the plume is more homo- geneously structured, pointing to new interpretations as to the make up of the starburst-driven outflow. Assuming that type IIa supernova remnants (SNRs) are mostly responsible for the E greater than 4 keV emission, the detection with EPIC of the 6.7 keV line allows us to estimate a supernova rate within the nuclear starburst of 0.2 /yr.

  10. Development of a species-diagnostic marker and its application for population genetics studies of the stingless bee Trigona collina in Thailand.

    PubMed

    Theeraapisakkun, M; Klinbunga, S; Sittipraneed, S

    2010-05-18

    A molecular maker for authenticating species origin of the stingless bee (Trigona collina) was developed. Initially, amplified fragment length polymorphism analysis was made of 11 stingless bee species using 64 primer combinations. A 316-bp band found only in T. collina was cloned and sequenced. A primer pair (CUTc1-F/R) was designed and tested for species-specificity in 15 stingless bee species (239 nests). The expected 259-bp fragment was consistently amplified in all T. collina individuals (134/134 nests, 100%). Cross-species amplification was observed in T. pagdeni (43/51 nests; 84.3%), but not in other species. SSCP analysis of CUTc1 unambiguously differentiated T. collina from T. pagdeni. CUTc1 generated three genotypes in Thai T. collina (134 nests). An AA (259/259 bp) genotype was found in all stingless bees from the north (21 nests) and northeast (32 nests), and 23/28 nests from the Central region, whereas a BB (253/253 bp) genotype was observed in most samples from peninsular Thailand (42/53 nests). Heterozygotes exhibiting the AB (253/259 bp) genotype were observed in 5 of 28 nests from Prachuap Khiri Khan located slightly above the Kra ecotone and 11 of 53 nests originated further south of the Kra ecotone. Genotype distribution patterns of CUTc1 clearly indicated intraspecific population differentiation of Thai T. collina.

  11. 20 CFR 632.253 - Special operating provisions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...: vocational exposure, counseling, testing, resume preparation, job interview preparation, providing labor... apprenticeship programs, and similar activities. It may be provided on a group or individual basis. In providing...

  12. 50 CFR 253.15 - Miscellaneous.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... due diligence investigation of every application it accepts and determine if, in the Division's sole... guarantee life. These must be conducted by competent and impartial inspectors acceptable to the Division...

  13. 50 CFR 253.25 - Other administrative requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... to submit along with the application a taxpayer identification number (TIN) (social security number... reproduced by any mechanical, magnetic or other process or medium. (e) Paperwork Reduction Act. The...

  14. 50 CFR 253.25 - Other administrative requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... to submit along with the application a taxpayer identification number (TIN) (social security number... reproduced by any mechanical, magnetic or other process or medium. (e) Paperwork Reduction Act. The...

  15. 50 CFR 253.25 - Other administrative requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... to submit along with the application a taxpayer identification number (TIN) (social security number... reproduced by any mechanical, magnetic or other process or medium. (e) Paperwork Reduction Act. The...

  16. 50 CFR 253.25 - Other administrative requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... to submit along with the application a taxpayer identification number (TIN) (social security number... reproduced by any mechanical, magnetic or other process or medium. (e) Paperwork Reduction Act. The...

  17. 32 CFR 253.6 - Procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... agency check (NAC), completed with favorable results, before being nominated for assignment with the...), Defense Investigative Service, for initiation of the NAC or BI, as appropriate. (e) Upon completion of the...

  18. 50 CFR 253.23 - Default and liquidation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... limited to, where appropriate, retaking or arrest of collateral, foreclosure, restructuring, debarment, referral for debt collection, or liquidation as it deems best able to protect the U.S. Government's...

  19. 50 CFR 253.23 - Default and liquidation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... limited to, where appropriate, retaking or arrest of collateral, foreclosure, restructuring, debarment, referral for debt collection, or liquidation as it deems best able to protect the U.S. Government's...

  20. 50 CFR 253.23 - Default and liquidation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... limited to, where appropriate, retaking or arrest of collateral, foreclosure, restructuring, debarment, referral for debt collection, or liquidation as it deems best able to protect the U.S. Government's...

  1. 50 CFR 253.23 - Default and liquidation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... limited to, where appropriate, retaking or arrest of collateral, foreclosure, restructuring, debarment, referral for debt collection, or liquidation as it deems best able to protect the U.S. Government's...

  2. The N253F mutant structure of trehalose synthase from Deinococcus radiodurans reveals an open active-site topology.

    PubMed

    Chow, Sih Yao; Wang, Yung Lin; Hsieh, Yu Chiao; Lee, Guan Chiun; Liaw, Shwu Huey

    2017-11-01

    Trehalose synthase (TS) catalyzes the reversible conversion of maltose to trehalose and belongs to glycoside hydrolase family 13 (GH13). Previous mechanistic analysis suggested a rate-limiting protein conformational change, which is probably the opening and closing of the active site. Consistently, crystal structures of Deinococcus radiodurans TS (DrTS) in complex with the inhibitor Tris displayed an enclosed active site for catalysis of the intramoleular isomerization. In this study, the apo structure of the DrTS N253F mutant displays a new open conformation with an empty active site. Analysis of these structures suggests that substrate binding induces a domain rotation to close the active site. Such a substrate-induced domain rotation has also been observed in some other GH13 enzymes.

  3. Bright Light Therapy for Treatment of Sleep Problems Following Mild TBI https://www.dacspr.documentservices.dla.mil/dtic/livelink func=formwf.formedit and workid=4132484 and subworkid=4132484 and taskid=8 and formID=1 and viewname=jhg and editable=1176347093 and nexturl=%2Fdtic%2Flivelink%3Ffunc%3Dwork%2Etaskdone%26workid%3D4132484%26subworkid%3D4132484%26taskid%3D8%26xAction%3Dsave%26paneindex%3D1%26nexturl%3D%252Fdtic%252Flivelink%253Ffunc%253Dllworkspace and noredisplay=1#

    DTIC Science & Technology

    2016-10-01

    00) and at night (between 00:00 and 04:00), and found that participants reported lower levels of sleepiness and fatigue, pii: sp-00684-15 ht tp...Chief Psychologist, GovSource, Inc., U.S. Department of Defense (DoD) Contractor 8/08 Consulting Psychologist, The Brain Institute, University of

  4. Influence of calcium carbonate and charcoal application on aggregation processes and organic matter retention at the silt-size scale

    NASA Astrophysics Data System (ADS)

    Asefaw Berhe, Asmeret; Kaiser, Michael; Ghezzehei, Teamrat; Myrold, David; Kleber, Markus

    2013-04-01

    The effectiveness of charcoal and calcium carbonate applications to improve soil conditions has been well documented. However, their influence on the formation of silt-sized aggregates and the amount and protection of associated organic matter (OM) against microbial decomposition is still largely unknown. For sustainable management of agricultural soils, silt-sized aggregates (2-53 µm) are of particularly large importance because they store up to 60% of soil organic carbon with mean residence times between 70 and 400 years. The objectives are i) to analyze the ability of CaCO3 and/or charcoal application to increase the amount of silt-sized aggregates and associated OM, ii) vary soil mineral conditions to establish relevant boundary conditions for amendment-induced aggregation processes, iii) to determine how amendment-induced changes in formation of silt-sized aggregates relate to microbial decomposition of OM. We set up artificial high reactive (HR, clay: 40%, sand: 57%, OM: 3%) and low reactive soils (LR, clay: 10%, sand: 89%, OM: 1%) and mixed them with charcoal (CC, 1%) and/or calcium carbonate (Ca, 0.2%). The samples were adjusted to a water potential of 0.3 bar and sub samples were incubated with microbial inoculum (MO). After a 16-weeks aggregation experiment, size fractions were separated by wet-sieving and sedimentation. Since we did not use mineral compounds in the artificial mixtures within the size range of 2 to 53 µm, we consider material recovered in this fraction as silt-sized aggregates, which was confirmed by SEM analyses. For the LR mixtures, we detected increasing N concentrations within the 2-53 µm fractions of the charcoal amended samples (CC, CC+Ca, and CC+Ca+MO) as compared to the Control sample with the strongest effect for the CC+Ca+MO sample. This indicates an association of N-containing microbial derived OM with silt-sized aggregates. For the charcoal amended LR and HR mixtures, the C concentrations of the 2-53 µm fractions are larger than those of the respective fractions of the Control samples but the effect is several times stronger for the LR mixtures. The C concentrations of the 2-53 µm fractions relative to the total C amount of the LR and HR mixtures are between 30 and 50%. The charcoal amended samples show generally larger relative C amounts associated with the 2-53 µm fractions than the Control samples. Benefits for aggregate formation and OM storage were larger for sand (LR) than for clay soil (HR). The gained data are similar to respective data for natural soils. Consequently, the suggested microcosm experiments are suitable to analyze mechanisms within soil aggregation processes.

  5. 7 CFR 1951.253 - Objectives.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATIONS (CONTINUED) SERVICING AND COLLECTIONS Analyzing Credit Needs and Graduation of Borrowers § 1951... which will be canceled when the loan is paid in full. (d) The Agency will enforce borrower graduation. ...

  6. 7 CFR 1951.253 - Objectives.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATIONS (CONTINUED) SERVICING AND COLLECTIONS Analyzing Credit Needs and Graduation of Borrowers § 1951... which will be canceled when the loan is paid in full. (d) The Agency will enforce borrower graduation. ...

  7. 7 CFR 1951.253 - Objectives.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATIONS (CONTINUED) SERVICING AND COLLECTIONS Analyzing Credit Needs and Graduation of Borrowers § 1951... which will be canceled when the loan is paid in full. (d) The Agency will enforce borrower graduation. ...

  8. 7 CFR 1951.253 - Objectives.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATIONS (CONTINUED) SERVICING AND COLLECTIONS Analyzing Credit Needs and Graduation of Borrowers § 1951... which will be canceled when the loan is paid in full. (d) The Agency will enforce borrower graduation. ...

  9. 78 FR 4978 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ...: Mill Inspection-- Report. --Welding Plant Inspection-- 2 railroads........ 2 reports 16 hours 32 Report...--Continuous Weld Rail-- 2 railroads........ 150 records........ 10 minutes........ 253 History--Records. 213...

  10. 24 CFR 213.253 - Premiums upon initial endorsement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... upon initial endorsement. (a) Management and Sales Types and Investor Sponsored Projects. The mortgagee... pursuant to the sale of an Investor Sponsored Project to such purchasing nonprofit cooperative housing...

  11. 40 CFR 98.252 - GHGs to report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 98.253(f) and the monitoring and QA/QC methods, missing data procedures, reporting requirements, and... methods, missing data procedures, reporting requirements, and recordkeeping requirements of subpart P of...

  12. 40 CFR 98.252 - GHGs to report.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... calculation methodologies from § 98.253(f) and the monitoring and QA/QC methods, missing data procedures... methods, missing data procedures, reporting requirements, and recordkeeping requirements of subpart P of...

  13. --No Title--

    Science.gov Websites

    .slide { position:relative; height:363px; width:858px; overflow:hidden; } .slideshow .description { box ; padding:16px; width:253px; height:331px; background-color:#393939; } .slideshow .description h2 { color

  14. 20 CFR 632.253 - Special operating provisions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... appropriate efforts to encourage educational agencies and post-secondary institutions to award academic credit... appropriate efforts are made to closely monitor the performance of the summer program and measure program...

  15. 17 CFR 230.253 - Offering circular.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... permitted. (2) Where an offering circular is distributed through an electronic medium, issuers may satisfy... COMPLETENESS OF ANY OFFERING CIRCULAR OR OTHER SELLING LITERATURE. THESE SECURITIES ARE OFFERED PURSUANT TO AN...

  16. 17 CFR 230.253 - Offering circular.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... permitted. (2) Where an offering circular is distributed through an electronic medium, issuers may satisfy... COMPLETENESS OF ANY OFFERING CIRCULAR OR OTHER SELLING LITERATURE. THESE SECURITIES ARE OFFERED PURSUANT TO AN...

  17. 37 CFR 253.7 - Recording rights, rates and terms.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... television programs of public broadcasting entities, whether or not in synchronization or timed relationship... actual recorded time period on the program, plus all distribution and broadcast information available to...

  18. 37 CFR 253.7 - Recording rights, rates and terms.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of public broadcasting entities, whether or not in synchronization or timed relationship with the... actual recorded time period on the program, plus all distribution and broadcast information available to...

  19. 37 CFR 253.7 - Recording rights, rates and terms.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of public broadcasting entities, whether or not in synchronization or timed relationship with the... actual recorded time period on the program, plus all distribution and broadcast information available to...

  20. 37 CFR 253.7 - Recording rights, rates and terms.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of public broadcasting entities, whether or not in synchronization or timed relationship with the... actual recorded time period on the program, plus all distribution and broadcast information available to...

  1. 40 CFR 98.252 - GHGs to report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... follow the calculation methodologies from § 98.253(f) and the monitoring and QA/QC methods, missing data..., monitoring and QA/QC methods, missing data procedures, reporting requirements, and recordkeeping requirements...

  2. 40 CFR 98.252 - GHGs to report.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... follow the calculation methodologies from § 98.253(f) and the monitoring and QA/QC methods, missing data..., monitoring and QA/QC methods, missing data procedures, reporting requirements, and recordkeeping requirements...

  3. 40 CFR 98.252 - GHGs to report.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... follow the calculation methodologies from § 98.253(f) and the monitoring and QA/QC methods, missing data..., monitoring and QA/QC methods, missing data procedures, reporting requirements, and recordkeeping requirements...

  4. UNCOVERING THE NUCLEUS CANDIDATE FOR NGC 253

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Günthardt, G. I.; Camperi, J. A.; Agüero, M. P.

    2015-11-15

    NGC 253 is the nearest spiral galaxy with a nuclear starburst that becomes the best candidate for studying the relationship between starburst and active galactic nucleus activity. However, this central region is veiled by large amounts of dust, and it has been so far unclear which is the true dynamical nucleus to the point that there is no strong evidence that the galaxy harbors a supermassive black hole co-evolving with the starburst as was supposed earlier. Near-infrared (NIR) spectroscopy, especially NIR emission line analysis, could be advantageous in shedding light on the true nucleus identity. Using Flamingos-2 at Gemini Southmore » we have taken deep K-band spectra along the major axis of the central structure and through the brightest infrared source. In this work, we present evidence showing that the brightest NIR and mid-infrared source in the central region, already known as radio source TH7 and so far considered just a large stellar supercluster, in fact presents various symptoms of a genuine galactic nucleus. Therefore, it should be considered a valid nucleus candidate. Mentioning some distinctive aspects, it is the most massive compact infrared object in the central region, located at 2.″0 of the symmetry center of the galactic bar, as measured in the K-band emission. Moreover, our data indicate that this object is surrounded by a large circumnuclear stellar disk and it is also located at the rotation center of the large molecular gas disk of NGC 253. Furthermore, a kinematic residual appears in the H{sub 2} rotation curve with a sinusoidal shape consistent with an outflow centered in the candidate nucleus position. The maximum outflow velocity is located about 14 pc from TH7, which is consistent with the radius of a shell detected around the nucleus candidate, observed at 18.3 μm (Qa) and 12.8 μm ([Ne ii]) with T-ReCS. Also, the Brγ emission line profile shows a pronounced blueshift and this emission line also has the highest equivalent width at this position. All this evidence points to TH7 as the best candidate for the galactic nucleus of NGC 253.« less

  5. Molecular Bases of Catalysis and ADP-Ribose Preference of Human Mn2+-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase and Conversion by Mutagenesis to a Preferential Cyclic ADP-Ribose Phosphohydrolase

    PubMed Central

    Cabezas, Alicia; Ribeiro, João Meireles; Rodrigues, Joaquim Rui; López-Villamizar, Iralis; Fernández, Ascensión; Canales, José; Pinto, Rosa María; Costas, María Jesús; Cameselle, José Carlos

    2015-01-01

    Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and zebrafish ADPRibase-Mn, the only biochemically studied, are phosphohydrolases of ADP-ribose and, somewhat less efficiently, of CDP-alcohols and 2´,3´-cAMP. Furthermore, the rat but not the zebrafish enzyme displays a unique phosphohydrolytic activity on cyclic ADP-ribose. The molecular basis of such specificity is unknown. Human ADPRibase-Mn showed similar activities, including cyclic ADP-ribose phosphohydrolase, which seems thus common to mammalian ADPRibase-Mn. Substrate docking on a homology model of human ADPRibase-Mn suggested possible interactions of ADP-ribose with seven residues located, with one exception (Cys253), either within the metallo-dependent phosphatases signature (Gln27, Asn110, His111), or in unique structural regions of the ADPRibase-Mn family: s2s3 (Phe37 and Arg43) and h7h8 (Phe210), around the active site entrance. Mutants were constructed, and kinetic parameters for ADP-ribose, CDP-choline, 2´,3´-cAMP and cyclic ADP-ribose were determined. Phe37 was needed for ADP-ribose preference without catalytic effect, as indicated by the increased ADP-ribose K m and unchanged k cat of F37A-ADPRibase-Mn, while the K m values for the other substrates were little affected. Arg43 was essential for catalysis as indicated by the drastic efficiency loss shown by R43A-ADPRibase-Mn. Unexpectedly, Cys253 was hindering for cADPR phosphohydrolase, as indicated by the specific tenfold gain of efficiency of C253A-ADPRibase-Mn with cyclic ADP-ribose. This allowed the design of a triple mutant (F37A+L196F+C253A) for which cyclic ADP-ribose was the best substrate, with a catalytic efficiency of 3.5´104 M-1s-1 versus 4´103 M-1s-1 of the wild type. PMID:25692488

  6. Retreived bacteria from Noctiluca miliaris (green) bloom of the northeastern Arabian Sea

    NASA Astrophysics Data System (ADS)

    Basu, Subhajit; Matondkar, S. G. Prabhu; Furtado, Irene

    2013-01-01

    In recent years, seasonal blooms of the dinoflagellate Noctiluca miliaris have appeared in the open-waters of the northern Arabian Sea (NAS). This study provides the first characterization of bacteria from a seasonal bloom of green Noctiluca of NAS (20°N-17°N and 64°E-70°E), during the spring-inter-monsoon cruise of Sagar Sampada 253, in March 2007. Bacterial growth as assessed by most-probable number (MPN) and plate counts, revealed `variable-physiotypes' over a wide range of salinities (0%-25% w/v NaCl), pH levels (5-8.5), and organic nutrient strengths, in comparison to non-bloom waters. MPN indices of bacteria in surface waters of bloom stations *DWK and *PRB, corresponded to (3.08-4.41)×103 cells/mL at 3.5% NaCl (w/v), and (2.82-9.49)×102 cells/mL at 25% (w/v) NaCl in tryptone-yeast extract broth (TYE). Plate counts were (1.12-4)×106 CFU/mL at 0% (w/v) NaCl, (1.28-3.9)×106 CFU/mL at 3.5% (w/v) NaCl, and (0.4-7)×104 CFU/mL at 25% NaCl (w/v) on TYE. One-tenth-strength Zobell's gave (0.6-3.74)×105 CFU/mL at pH 5 to (3.58-7.5)×105 CFU/mL at pH 8.5. These bacteria were identified to the genera Bacillus, Cellulomonas, Staphylococcus, Planococcus, Dietzia, Virgibacillus, Micrococcus, Sporosarcinae, Leucobacter, and Halomonas. The identity of three strains (GUFBSS253N2, GUFBSS253N30, and GUFBSS253N84) was confirmed through 16S rDNA sequence homology as Bacillus cohnii, Bacillus flexus, and Bacillus cereus. The ˜2-3-fold higher plate counts of culturable bacteria from the open-waters of the NAS indicate that these bacteria could critically determine the biogeochemical dynamics of the bloom and its milieu. The role of these bacteria in sustaining/terminating the bloom is under evaluation.

  7. 50 CFR 253.21 - Apportionment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... calendar years for which data satisfactory to the Secretary are available bears to the total equally... under an interstate fishery management plan; (3) Borders one or more of the Great Lakes; (4) Has entered...

  8. 50 CFR 253.51 - Apportionment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... calendar years for which data satisfactory to the Secretary are available bears to the total equally... under an interstate fishery management plan; (3) Borders one or more of the Great Lakes; (4) Has entered...

  9. 50 CFR 253.51 - Apportionment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... calendar years for which data satisfactory to the Secretary are available bears to the total equally... under an interstate fishery management plan; (3) Borders one or more of the Great Lakes; (4) Has entered...

  10. 50 CFR 253.51 - Apportionment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... calendar years for which data satisfactory to the Secretary are available bears to the total equally... under an interstate fishery management plan; (3) Borders one or more of the Great Lakes; (4) Has entered...

  11. 50 CFR 253.51 - Apportionment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... calendar years for which data satisfactory to the Secretary are available bears to the total equally... under an interstate fishery management plan; (3) Borders one or more of the Great Lakes; (4) Has entered...

  12. 27 CFR 44.253 - Tax classification for cigars.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE... in the package; and (c) For small cigars, the classification of the product for tax purposes (i.e...

  13. 27 CFR 44.253 - Tax classification for cigars.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE... in the package; and (c) For small cigars, the classification of the product for tax purposes (i.e...

  14. 27 CFR 44.253 - Tax classification for cigars.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE... in the package; and (c) For small cigars, the classification of the product for tax purposes (i.e...

  15. 27 CFR 44.253 - Tax classification for cigars.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE... in the package; and (c) For small cigars, the classification of the product for tax purposes (i.e...

  16. 27 CFR 44.253 - Tax classification for cigars.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION OF TOBACCO PRODUCTS AND CIGARETTE... in the package; and (c) For small cigars, the classification of the product for tax purposes (i.e...

  17. 37 CFR 253.7 - Recording rights, rates and terms.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the public broadcasting entity. (e) Filing of use reports with the Copyright Office. Deposit of cue... public broadcasting entities shall maintain and make available for examination pursuant to subsection (e...

  18. ARC-2010-ACD10-0052-057

    NASA Image and Video Library

    2010-03-20

    For Inspiration and Recognition of Science and Technology; FIRST Robotics Competition 2010 Silicon Valley Regional held at San Jose State University, San Jose, California Mills Robotics Team, Mills H.S, CA Team 253

  19. 8 CFR 253.1 - Parole.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., tuberculosis in any form, leprosy, or any dangerous contagious disease, or an alien crewman suspected of being... strictly in the public interest be paroled into the United States under the provisions of section 212(d)(5...

  20. 33 CFR 117.253 - Anacostia River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... traffic lights will flash red, and an audio voice-warning device will announce bridge movement during... condition two board gauges painted white with black figures not less than six inches high to indicate the...

  1. 33 CFR 117.253 - Anacostia River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... traffic lights will flash red, and an audio voice-warning device will announce bridge movement during... condition two board gauges painted white with black figures not less than six inches high to indicate the...

  2. 2. NORTH (FRONT) AND WEST SIDE ELEVATIONS, LOOKING SOUTHEAST, (WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. NORTH (FRONT) AND WEST SIDE ELEVATIONS, LOOKING SOUTHEAST, (WITH TOM SHAW IN PHONE BOOTH) - Paris Mountain State Park, Bathhouse, Paris Mountain State Park, off SC Route 253, Greenville, Greenville, SC

  3. 7 CFR 2.53 - Administrator, Food Safety and Inspection Service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... certification of technical animal fat; certified products for dogs, cats and other carnivora; voluntary... agricultural sciences (7 U.S.C. 3318). (9) Conduct an education program regarding the availability and safety...

  4. 7 CFR 2.53 - Administrator, Food Safety and Inspection Service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certification of technical animal fat; certified products for dogs, cats and other carnivora; voluntary... agricultural sciences (7 U.S.C. 3318). (9) Conduct an education program regarding the availability and safety...

  5. 7 CFR 2.53 - Administrator, Food Safety and Inspection Service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... certification of technical animal fat; certified products for dogs, cats and other carnivora; voluntary... agricultural sciences (7 U.S.C. 3318). (9) Conduct an education program regarding the availability and safety...

  6. 7 CFR 2.53 - Administrator, Food Safety and Inspection Service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... certification of technical animal fat; certified products for dogs, cats and other carnivora; voluntary... agricultural sciences (7 U.S.C. 3318). (9) Conduct an education program regarding the availability and safety...

  7. 7 CFR 2.53 - Administrator, Food Safety and Inspection Service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... certification of technical animal fat; certified products for dogs, cats and other carnivora; voluntary... agricultural sciences (7 U.S.C. 3318). (9) Conduct an education program regarding the availability and safety...

  8. 7 CFR 253.10 - Commodity control, storage and distribution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... recorded. (15) Posters are conspicuously displayed advising program participants to accept only those... commodities with the same or similar kind of commodities which are sound and in good condition. The State...

  9. 40 CFR 265.253 - Containment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... discharge from at least a 25-year storm; (3) The owner or operator must design, construct, operate, and...-hour, 25-year storm; and (4) Collection and holding facilities (e.g., tanks or basins) associated with...

  10. 40 CFR 265.253 - Containment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... discharge from at least a 25-year storm; (3) The owner or operator must design, construct, operate, and...-hour, 25-year storm; and (4) Collection and holding facilities (e.g., tanks or basins) associated with...

  11. 40 CFR 265.253 - Containment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... discharge from at least a 25-year storm; (3) The owner or operator must design, construct, operate, and...-hour, 25-year storm; and (4) Collection and holding facilities (e.g., tanks or basins) associated with...

  12. 40 CFR 265.253 - Containment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... discharge from at least a 25-year storm; (3) The owner or operator must design, construct, operate, and...-hour, 25-year storm; and (4) Collection and holding facilities (e.g., tanks or basins) associated with...

  13. 40 CFR 265.253 - Containment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... discharge from at least a 25-year storm; (3) The owner or operator must design, construct, operate, and...-hour, 25-year storm; and (4) Collection and holding facilities (e.g., tanks or basins) associated with...

  14. 37 CFR 253.6 - Performance of musical compositions by other public broadcasting entities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES USE OF... colleges, universities, or other nonprofit educational institutions and which are not affiliated with...

  15. 8 CFR 253.1 - Parole.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... last habitual residence (if not a national of any country) because of fear of persecution in that... opinion, or because of fear of torture is eligible to apply for asylum or withholding of removal under 8...

  16. Nuclear Data Sheets for A = 251–259 (odd)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Browne, E.; Tuli, J.K.

    The evaluators present in this publication spectroscopic data and level schemes from radioactive decay and nuclear reaction studies for all known nuclei with mass numbers A = 251, 253, 255, 257, and 259.

  17. Victims Protection Act of 2013

    THOMAS, 113th Congress

    Sen. McCaskill, Claire [D-MO

    2013-11-21

    Senate - 12/09/2013 Read the second time. Placed on Senate Legislative Calendar under General Orders. Calendar No. 253. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  18. 39 CFR 551.1 - Semipostal Stamp Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Public Law 106-253, 114 Stat. 634 (2000), as amended by Public Law 107-67, section 652, 115 Stat. 514... Program. The Office of Accounting, Finance, Controller has primary responsibility for the financial...

  19. Apert Syndrome: Molecularly Confirmed C.758C>G (P.Pro253Arg) in FGFR2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cha Gon, Lee, E-mail: leechagon@eulji.ac.kr

    A 5-day-old girl was referred to our clinic for evaluation of congenital malformations. She was identified with a pathogenic mutation c.758C>G (p.Pro253Arg) in FGFR2 gene using targeted exome sequencing. The de novo mutation was confirmed with Sanger sequencing in the patient and her parents. She showed occipital plagiocephaly with frontal bossing (Figure A and B). Skull frontal and lateral radiography revealed fusion of most of the sutures except coronal suture, with convolutional markings (Figure D and E). She had complete cleft palate (Figure C). Her fused bilateral hands showed type II syndactyly with complete syndactyly between the ring and themore » little fingers (Figure F1-F3). Both toes were simple syndactyly with side-to-side fusion of skin (Figure G1-)« less

  20. Aerodynamic Characteristics of a 45 Degree Swept-wing Fighter-Airplane Model and Aerodynamic Loads on Adjacent Stores and Missiles at Mach Numbers of 1.57, 1.87, 2.16, and 2.53

    NASA Technical Reports Server (NTRS)

    Oehman, Waldo I; Turner, Kenneth L

    1958-01-01

    An investigation was performed in the Langley Unitary Plan wind tunnel to determine the aerodynamic characteristics of a model of a 450 swept-wing fighter airplane, and to determine the loads on attached stores and detached missiles in the presence of the model. Also included was a determination of aileron-spoiler effectiveness, aileron hinge moments, and the effects of wing modifications on model aerodynamic characteristics. Tests were performed at Mach numbers of 1.57, 1.87, 2.16, and 2.53. The Reynolds numbers for the tests, based on the mean aerodynamic chord of the wing, varied from about 0.9 x 10(exp 6) to 5 x 10(exp 6). The results are presented with minimum analysis.

  1. Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Slaney, S.F.; Oldridge, M.; Wilkie, A.O.M.

    1996-05-01

    Apert syndrome is a distinctive human malformation characterized by craniosynostosis and severe syndactyly of the hands and feet. It is caused by specific missense substitutions involving adjacent amino acids (Ser252Trp or Pro253Arg) in the linker between the second and third extracellular immunoglobulin domains of fibroblast growth factor receptor 2 (FGFR2). We have developed a simple PCR assay for these mutations in genomic DNA, based on the creation of novel SfiI and BstUI restriction sites. Analysis of DNA from 70 unrelated patients with Apert syndrome showed that 45 had the Ser252Trp mutation and 25 had the Pro253Arg mutation. Phenotypic differences betweenmore » these two groups of patients were investigated. Significant differences were found for severity of syndactyly and presence of cleft palate. The syndactyly was more severe with the Pro253Arg mutation, for both the hands and the feet. In contrast, cleft palate was significantly more common in the Ser252Trp patients. No convincing differences were found in the prevalence of other malformations associated with Apert syndrome. We conclude that, although the phenotype attributable to the two mutations is very similar, there are subtle differences. The opposite trends for severity of syndactyly and cleft palate in relation to the two mutations may relate to the varying patterns of temporal and tissue-specific expression of different fibroblast growth factors, the ligands for FGFR2. 54 refs., 5 figs., 3 tabs.« less

  2. Ubiquinol-binding site in the alternative oxidase: mutagenesis reveals features important for substrate binding and inhibition.

    PubMed

    Albury, Mary S; Elliott, Catherine; Moore, Anthony L

    2010-12-01

    The alternative oxidase (AOX) is a non-protonmotive ubiquinol oxidase that is found in all plants, some fungi, green algae, bacteria and pathogenic protozoa. The lack of AOX in the mammalian host renders this protein an important potential therapeutic target in the treatment of pathogenic protozoan infections. Bioinformatic searches revealed that, within a putative ubiquinol-binding crevice in AOX, Gln242, Asn247, Tyr253, Ser256, His261 and Arg262 were highly conserved. To confirm that these amino-acid residues are important for ubiquinol-binding and hence activity substitution mutations were generated and characterised. Assessment of AOX activity in isolated Schizosaccharomyces pombe mitochondria revealed that mutation of either Gln242, Ser256, His261 and Arg262 resulted in >90% inhibition of antimycin A-insensitive respiration suggesting that hydroxyl, guanidino, imidazole groups, polar and charged residues in addition to the size of the amino-acid chain are important for ubiquinone-binding. Substitution of Asn247 with glutamine or Tyr253 with phenylalanine had little effect upon the respiratory rate indicating that these residues are not critical for AOX activity. However replacement of Tyr253 by alanine resulted in a 72% loss of activity suggesting that the benzoquinone group and not hydroxyl group is important for quinol binding. These results provide important new insights into the ubiquinol-binding site of the alternative oxidase, the identity of which maybe important for future rational drug design. Copyright © 2010 Elsevier B.V. All rights reserved.

  3. Method and apparatus for monitoring the flow of mercury in a system

    DOEpatents

    Grossman, Mark W.

    1987-01-01

    An apparatus and method for monitoring the flow of mercury in a system. The equipment enables the entrainment of the mercury in a carrier gas e.g., an inert gas, which passes as mercury vapor between a pair of optically transparent windows. The attenuation of the emission is indicative of the quantity of mercury (and its isotopes) in the system. A 253.7 nm light is shone through one of the windows and the unabsorbed light is detected through the other window. The absorption of the 253.7 nm light is thereby measured whereby the quantity of mercury passing between the windows can be determined. The apparatus includes an in-line sensor for measuring the quantity of mercury. It includes a conduit together with a pair of apertures disposed in a face to face relationship and arranged on opposite sides of the conduit. A pair of optically transparent windows are disposed upon a pair of viewing tubes. A portion of each of the tubes is disposed inside of the conduit and within each of the apertures. The two windows are disposed in a face to face relationship on the ends of the viewing tubes and the entire assembly is hermetically sealed from the atmosphere whereby when 253.7 nm ultraviolet light is shone through one of the windows and detected through the other, the quantity of mercury which is passing by can be continuously monitored due to absorption which is indicated by attenuation of the amplitude of the observed emission.

  4. Internalisation of the bleomycin molecules responsible for bleomycin toxicity: a receptor-mediated endocytosis mechanism.

    PubMed

    Pron, G; Mahrour, N; Orlowski, S; Tounekti, O; Poddevin, B; Belehradek, J; Mir, L M

    1999-01-01

    Bleomycin (BLM) does not diffuse through the plasma membrane but nevertheless displays cytotoxic activity due to DNA break generation. The aim of the study was to describe the mechanism of BLM internalisation. We previously provided evidence for the existence of BLM-binding sites at the surface of DC-3F Chinese hamster fibroblasts, as well as of their involvement in BLM cytotoxicity on DC-3F cells and related BLM-resistant sublines. Here we report that A253 human cells and their BLM-resistant subline C-10E also possessed a membrane protein of ca. 250 kDa specifically binding BLM. Part of this C-10E cell resistance could be explained by a decrease in the number of BLM-binding sites exposed at the cell surface with respect to A253 cells. The comparison between A253 and DC-3F cells exposing a similar number of BLM-binding sites revealed that the faster the fluid phase endocytosis, the greater the cell sensitivity to BLM. Moreover, the experimental modification of endocytotic vesicle size showed that BLM cytotoxicity was directly correlated with the flux of plasma membrane area engulfed during endocytosis rather than with the fluid phase volume incorporated. Thus, BLM would be internalised by a receptor-mediated endocytosis mechanism which would first require BLM binding to its membrane receptor and then the transfer of the complex into intracellular endocytotic vesicles, followed by BLM entry into the cytosol, probably from a nonacidic compartment.

  5. Refinement of the critical 2p25.3 deletion region: the role of MYT1L in intellectual disability and obesity.

    PubMed

    De Rocker, Nina; Vergult, Sarah; Koolen, David; Jacobs, Eva; Hoischen, Alexander; Zeesman, Susan; Bang, Birgitte; Béna, Frédérique; Bockaert, Nele; Bongers, Ernie M; de Ravel, Thomy; Devriendt, Koenraad; Giglio, Sabrina; Faivre, Laurence; Joss, Shelagh; Maas, Saskia; Marle, Nathalie; Novara, Francesca; Nowaczyk, Malgorzata J M; Peeters, Hilde; Polstra, Abeltje; Roelens, Filip; Rosenberg, Carla; Thevenon, Julien; Tümer, Zeynep; Vanhauwaert, Suzanne; Varvagiannis, Konstantinos; Willaert, Andy; Willemsen, Marjolein; Willems, Marjolaine; Zuffardi, Orsetta; Coucke, Paul; Speleman, Frank; Eichler, Evan E; Kleefstra, Tjitske; Menten, Björn

    2015-06-01

    Submicroscopic deletions of chromosome band 2p25.3 are associated with intellectual disability and/or central obesity. Although MYT1L is believed to be a critical gene responsible for intellectual disability, so far no unequivocal data have confirmed this hypothesis. In this study we evaluated a cohort of 22 patients (15 sporadic patients and two families) with a 2p25.3 aberration to further refine the clinical phenotype and to delineate the role of MYT1L in intellectual disability and obesity. In addition, myt1l spatiotemporal expression in zebrafish embryos was analyzed by quantitative polymerase chain reaction and whole-mount in situ hybridization. Complete MYT1L deletion, intragenic deletion, or duplication was observed in all sporadic patients, in addition to two patients with a de novo point mutation in MYT1L. The familial cases comprise a 6-Mb deletion in a father and his three children and a 5' MYT1L overlapping duplication in a father and his two children. Expression analysis in zebrafish embryos shows specific myt1l expression in the developing brain. Our data strongly strengthen the hypothesis that MYT1L is the causal gene for the observed syndromal intellectual disability. Moreover, because 17 patients present with obesity/overweight, haploinsufficiency of MYT1L might predispose to weight problems with childhood onset.Genet Med 17 6, 460-466.

  6. 7 CFR 25.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Migration, as such terms are defined for purposes of the 1990 Census. Poverty rate means, for a given Census tract, the poverty rate reported in Table 19 of the Bureau of the Census CPH-3 series of publications...

  7. 7 CFR 25.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Migration, as such terms are defined for purposes of the 1990 Census. Poverty rate means, for a given Census tract, the poverty rate reported in Table 19 of the Bureau of the Census CPH-3 series of publications...

  8. 7 CFR 25.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Migration, as such terms are defined for purposes of the 1990 Census. Poverty rate means, for a given Census tract, the poverty rate reported in Table 19 of the Bureau of the Census CPH-3 series of publications...

  9. 29 CFR 1910.253 - Oxygen-fuel gas welding and cutting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... threads to which permanent connections are to be made, such as to a machine. (vii) Station outlets shall... materials or processes. (6) Outside generator houses and inside generator rooms for stationary acetylene...

  10. 29 CFR 1910.253 - Oxygen-fuel gas welding and cutting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... threads to which permanent connections are to be made, such as to a machine. (vii) Station outlets shall... materials or processes. (6) Outside generator houses and inside generator rooms for stationary acetylene...

  11. 29 CFR 1910.253 - Oxygen-fuel gas welding and cutting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... threads to which permanent connections are to be made, such as to a machine. (vii) Station outlets shall... materials or processes. (6) Outside generator houses and inside generator rooms for stationary acetylene...

  12. 29 CFR 1910.253 - Oxygen-fuel gas welding and cutting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... threads to which permanent connections are to be made, such as to a machine. (vii) Station outlets shall... materials or processes. (6) Outside generator houses and inside generator rooms for stationary acetylene...

  13. 7 CFR 254.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... tribe, as defined in § 253.2(d) of this title. (e) Indian tribal organization (ITO) means (1) any Indian... to receive. (g) State agency means the ITO of an Indian tribe, determined by the Department to be...

  14. Publications - GMC 253 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    of the following Copper River basin oil and gas exploratory wells: Amoco Production Company Ahtna Inc Reference Unknown, 1995, Source rock geochemical and visual kerogen data from cuttings of the following

  15. 76 FR 50443 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... the of Hull, Town of intersection of Brant Marion, Town of Beach Avenue and Ocean Mattapoisett, Town..., MA 02043. Town of Hull Maps are available for inspection at the Town Hall, 253 Atlantic Avenue, Hull...

  16. Genetics Home Reference: lamellar ichthyosis

    MedlinePlus

    ... 1 mutations in patients affected by lamellar ichthyosis. Cell Death Dis. 2012 Oct 25;3:e416. doi: 10.1038/cddis.2012.152. ... are genome editing and CRISPR-Cas9? What is precision medicine? What is newborn ...

  17. 75 FR 54114 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ...--Shoulder Rest, Telephone, Black, Softak II. NSN: 7520-00-NIB-2085--Shoulder Rest, Telephone, Black... Administration. NSN: 7520-01-253-1283--Shoulder Rest, Telephone, Beige, 2\\1/4\\'' W x 7'' L. NSN: 7520-01-377-9533...

  18. 14 CFR 93.253 - Nonstop operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Ronald Reagan Washington National Airport... between Ronald Reagan Washington National Airport and another airport that is more than 1,250 miles away from Ronald Reagan Washington National Airport. ...

  19. 14 CFR 93.253 - Nonstop operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Ronald Reagan Washington National Airport... between Ronald Reagan Washington National Airport and another airport that is more than 1,250 miles away from Ronald Reagan Washington National Airport. ...

  20. Approach view of the Spring Creek Bridge, view looking south. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Approach view of the Spring Creek Bridge, view looking south. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  1. General perspective view of the Spring Creek Bridge, view looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General perspective view of the Spring Creek Bridge, view looking southeast. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  2. Elevation view of the Spring Creek Bridge, view looking east. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation view of the Spring Creek Bridge, view looking east. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  3. General perspective view of the Spring Creek Bridge, view looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General perspective view of the Spring Creek Bridge, view looking northwest. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  4. Approach view of the Spring Creek Bridge, view looking north. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Approach view of the Spring Creek Bridge, view looking north. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  5. General perspective view of the Spring Creek Bridge, view looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General perspective view of the Spring Creek Bridge, view looking east. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  6. 40 CFR 180.253 - Methomyl; tolerances for residues.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., tops 6 Bermudagrass, forage 10 Bermudagrass, hay 40 Blueberry 6 Broccoli 3 Brussels sprouts 2 Cabbage 5..., brassica, leafy, group 5 6.0 Vegetable, fruiting 0.2(N) Vegetables, leafy [exc. beet (tops), broccoli...

  7. 7 CFR 1901.253 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE..., sites, buildings, structures, and objects, significant in American history, architecture, archeology... significance in American History, Architecture, Archeology, and the culture is present in districts, sites...

  8. 14 CFR 253.8 - Qualifications to notice requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... without penalty. (b) An air taxi operator (including a commuter air carrier) not operating under subpart I..., such an air taxi operator may not claim the benefit as against the passenger of, and the passenger...

  9. 14 CFR 253.8 - Qualifications to notice requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... without penalty. (b) An air taxi operator (including a commuter air carrier) not operating under subpart I..., such an air taxi operator may not claim the benefit as against the passenger of, and the passenger...

  10. Combat Neurosis in the Battered Teacher.

    ERIC Educational Resources Information Center

    Science News, 1978

    1978-01-01

    Investigates the effect of school violence on classroom teachers. The study of 253 Los Angeles inner city classroom teachers reveals that many of them have developed conditions similar to the combat neurosis found in soldiers at war. (HM)

  11. 48 CFR 11.002 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., 41 U.S.C. 253a(a), and 41 U.S.C. 264b, agencies shall— (1) Specify needs using market research in a... significant inefficiencies or loss of markets to United States firms. Requiring activities are responsible for...

  12. 6 CFR 25.3 - Delegation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... under the SAFETY Act, except the authority to declare that an act is an Act of Terrorism for purposes of section 865(2) of the SAFETY Act, may be exercised by the Under Secretary for Science and Technology of...

  13. 42 CFR 84.253 - Chemical-cartridge respirators; requirements and tests.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... combination rather than the individual cartridges. (2) Four cartridges or pairs of cartridges will be... respirator by a breathing machine at a concentration of 10 ppm vinyl chloride monomer at the rate of 24...

  14. 42 CFR 84.253 - Chemical-cartridge respirators; requirements and tests.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... combination rather than the individual cartridges. (2) Four cartridges or pairs of cartridges will be... respirator by a breathing machine at a concentration of 10 ppm vinyl chloride monomer at the rate of 24...

  15. Probing Sizes and Shapes of Nobelium Isotopes by Laser Spectroscopy

    NASA Astrophysics Data System (ADS)

    Raeder, S.; Ackermann, D.; Backe, H.; Beerwerth, R.; Berengut, J. C.; Block, M.; Borschevsky, A.; Cheal, B.; Chhetri, P.; Düllmann, Ch. E.; Dzuba, V. A.; Eliav, E.; Even, J.; Ferrer, R.; Flambaum, V. V.; Fritzsche, S.; Giacoppo, F.; Götz, S.; Heßberger, F. P.; Huyse, M.; Kaldor, U.; Kaleja, O.; Khuyagbaatar, J.; Kunz, P.; Laatiaoui, M.; Lautenschläger, F.; Lauth, W.; Mistry, A. K.; Minaya Ramirez, E.; Nazarewicz, W.; Porsev, S. G.; Safronova, M. S.; Safronova, U. I.; Schuetrumpf, B.; Van Duppen, P.; Walther, T.; Wraith, C.; Yakushev, A.

    2018-06-01

    Until recently, ground-state nuclear moments of the heaviest nuclei could only be inferred from nuclear spectroscopy, where model assumptions are required. Laser spectroscopy in combination with modern atomic structure calculations is now able to probe these moments directly, in a comprehensive and nuclear-model-independent way. Here we report on unique access to the differential mean-square charge radii of No 252 ,253 ,254 , and therefore to changes in nuclear size and shape. State-of-the-art nuclear density functional calculations describe well the changes in nuclear charge radii in the region of the heavy actinides, indicating an appreciable central depression in the deformed proton density distribution in No,254252 isotopes. Finally, the hyperfine splitting of No 253 was evaluated, enabling a complementary measure of its (quadrupole) deformation, as well as an insight into the neutron single-particle wave function via the nuclear spin and magnetic moment.

  16. A survey of fish viruses isolated from wild marine fishes from the coastal waters of southern Korea.

    PubMed

    Kim, Wi-Sik; Choi, Shin-Young; Kim, Do-Hyung; Oh, Myung-Joo

    2013-11-01

    A survey was conducted to investigate viral infection in 253 wild marine fishes harvested in the southern coastal area of Korea from 2010 to 2012. The fish that were captured by local anglers were randomly bought and sampled for virus examination. The samples were tested for presence of virus by virus isolation with FHM, FSP, and BF-2 cells and molecular methods (polymerase chain reaction and sequencing). Of the 253 fish sampled, 9 fish were infected with virus. Aquabirnaviruses (ABVs), Viral hemorrhagic septicemia virus (VHSV), and Red seabream iridovirus (RSIV) were detected in 7, 1, and 1 fish, respectively. Molecular phylogenies demonstrated the detected viruses (ABV, VHSV, and RSIV) were more closely related to viruses reported of the same type from Korea and Japan than from other countries, suggesting these viruses may be indigenous to Korean and Japanese coastal waters.

  17. Search for microquasar features in cosmic ray spectra with AMS-01

    NASA Astrophysics Data System (ADS)

    Monreal, Benjamin

    2004-12-01

    Accreting x-ray binaries are sometimes observed to emit compact, relativistic jets of cool plasma; these objects are called "microquasars". It is possible that these jets are responsible for a large flux of galactic cosmic ray protons and nuclei. The energy spectrum from these sources will be very different from the featureless power-law expected from ordinary cosmic-ray acceleration in supernova shocks. The AMS-01 instrument measured cosmic ray protons and helium during 10 days on the Space Shuttle Discovery in 1998; we analyze this data searching for spectral distortions due to nearby microquasar activity. We show that the microquasar contribution to the CR proton flux can be no more than ~2% in the range 2-50 GeV. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  18. Mutagenesis of the Phosphatidylinositol 4,5-Bisphosphate (Pip2) Binding Site in the Nh2-Terminal Domain of Ezrin Correlates with Its Altered Cellular Distribution

    PubMed Central

    Barret, Cécile; Roy, Christian; Montcourrier, Philippe; Mangeat, Paul; Niggli, Verena

    2000-01-01

    The cytoskeleton-membrane linker protein ezrin has been shown to associate with phosphatidyl-inositol 4,5-bisphosphate (PIP2)-containing liposomes via its NH2-terminal domain. Using internal deletions and COOH-terminal truncations, determinants of PIP2 binding were located to amino acids 12–115 and 233–310. Both regions contain a KK(X)nK/RK motif conserved in the ezrin/radixin/moesin family. K/N mutations of residues 253 and 254 or 262 and 263 did not affect cosedimentation of ezrin 1-333 with PIP2-containing liposomes, but their combination almost completely abolished the capacity for interaction. Similarly, double mutation of Lys 63, 64 to Asn only partially reduced lipid interaction, but combined with the double mutation K253N, K254N, the interaction of PIP2 with ezrin 1-333 was strongly inhibited. Similar data were obtained with full-length ezrin. When residues 253, 254, 262, and 263 were mutated in full-length ezrin, the in vitro interaction with the cytoplasmic tail of CD44 was not impaired but was no longer PIP2 dependent. This construct was also expressed in COS1 and A431 cells. Unlike wild-type ezrin, it was not any more localized to dorsal actin-rich structures, but redistributed to the cytoplasm without strongly affecting the actin-rich structures. We have thus identified determinants of the PIP2 binding site in ezrin whose mutagenesis correlates with an altered cellular localization. PMID:11086008

  19. Diverse Nuclear Star-forming Activities in the Heart of NGC 253 Resolved with 10-pc-scale ALMA Images

    NASA Astrophysics Data System (ADS)

    Ando, Ryo; Nakanishi, Kouichiro; Kohno, Kotaro; Izumi, Takuma; Martín, Sergio; Harada, Nanase; Takano, Shuro; Kuno, Nario; Nakai, Naomasa; Sugai, Hajime; Sorai, Kazuo; Tosaki, Tomoka; Matsubayashi, Kazuya; Nakajima, Taku; Nishimura, Yuri; Tamura, Yoichi

    2017-11-01

    We present an 8 pc × 5 pc resolution view of the central ˜200 pc region of the nearby starburst galaxy NGC 253, based on ALMA Band 7 (λ ≃ 0.85 {mm} or ν ˜ 350 GHz) observations covering 11 GHz. We resolve the nuclear starburst of NGC 253 into eight dusty star-forming clumps, 10 pc in scale, for the first time. These clumps, each of which contains (4-10) × {10}4 {M}⊙ of dust (assuming that the dust temperature is 25 K) and up to 6× {10}2 massive (O5V) stars, appear to be aligned in two parallel ridges, while they have been blended in previous studies. Despite the similarities in sizes and dust masses of these clumps, their line spectra vary drastically from clump to clump, although they are separated by only ˜10 pc. Specifically, one of the clumps, Clump 1, exhibits line-confusion-limited spectra with at least 36 emission lines from 19 molecules (including CH3OH, HNCO, H2CO, CH3CCH, H2CS, and H3O+) and a hydrogen recombination line (H26α), while far fewer kinds of molecular lines are detected in some other clumps where fragile species, such as complex organic molecules and HNCO, completely disappear from their spectra. We demonstrate the existence of hot molecular gas ({T}{rot}({{SO}}2)=90+/- 11 K) in the former clump, which suggests that the hot and chemically rich environments are localized within a 10-pc-scale star-forming clump.

  20. Characterization of an ATP-dependent DNA ligase from the thermophilic archaeon Methanobacterium thermoautotrophicum.

    PubMed

    Sriskanda, V; Kelman, Z; Hurwitz, J; Shuman, S

    2000-06-01

    We report the production, purification and characterization of a DNA ligase encoded by the thermophilic archaeon Methanobacterium thermoautotrophicum. The 561 amino acid MTH: ligase catalyzed strand-joining on a singly nicked DNA in the presence of a divalent cation (magnesium, manganese or cobalt) and ATP (K(m) 1.1 microM). dATP can substitute for ATP, but CTP, GTP, UTP and NAD(+) cannot. MTH: ligase activity is thermophilic in vitro, with optimal nick-joining at 60 degrees C. Mutational analysis of the conserved active site motif I (KxDG) illuminated essential roles for Lys251 and Asp253 at different steps of the ligation reaction. Mutant K251A is unable to form the covalent ligase-adenylate intermediate (step 1) and hence cannot seal a 3'-OH/5'-PO(4) nick. Yet, K251A catalyzes phosphodiester bond formation at a pre-adenylated nick (step 3). Mutant D253A is active in ligase-adenylate formation, but defective in activating the nick via formation of the DNA-adenylate intermediate (step 2). D253A is also impaired in phosphodiester bond formation at a pre-adenylated nick. A profound step 3 arrest, with accumulation of high levels of DNA-adenylate, could be elicited for the wild-type MTH: ligase by inclusion of calcium as the divalent cation cofactor. MTH: ligase sediments as a monomer in a glycerol gradient. Structure probing by limited proteolysis suggested that MTH: ligase is a tightly folded protein punctuated by a surface-accessible loop between nucleotidyl transferase motifs III and IIIa.

  1. Method and apparatus for monitoring the flow of mercury in a system

    DOEpatents

    Grossman, M.W.

    1987-12-15

    An apparatus and method for monitoring the flow of mercury in a system are disclosed. The equipment enables the entrainment of the mercury in a carrier gas e.g., an inert gas, which passes as mercury vapor between a pair of optically transparent windows. The attenuation of the emission is indicative of the quantity of mercury (and its isotopes) in the system. A 253.7 nm light is shone through one of the windows and the unabsorbed light is detected through the other window. The absorption of the 253.7 nm light is thereby measured whereby the quantity of mercury passing between the windows can be determined. The apparatus includes an in-line sensor for measuring the quantity of mercury. It includes a conduit together with a pair of apertures disposed in a face to face relationship and arranged on opposite sides of the conduit. A pair of optically transparent windows are disposed upon a pair of viewing tubes. A portion of each of the tubes is disposed inside of the conduit and within each of the apertures. The two windows are disposed in a face to face relationship on the ends of the viewing tubes and the entire assembly is hermetically sealed from the atmosphere whereby when 253.7 nm ultraviolet light is shone through one of the windows and detected through the other, the quantity of mercury which is passing by can be continuously monitored due to absorption which is indicated by attenuation of the amplitude of the observed emission. 4 figs.

  2. 76 FR 46300 - Food and Drug Administration Modernization Act of 1997: Modifications to the List of Recognized...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-02

    ... 62366:2007. engineering to medical devices. D. General Hospital/General Plastic Surgery: 6-253 Hoists... CLSI H59-A. Thromboembolic Disease; Approved Guideline. F. Nanotechnology: 18-2 Standard Guide for...

  3. 50 CFR 253.10 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... less overutilized species than before; applying new technology; improving safety or fuel efficiency..., growth, productivity, or any other business attribute. Demand means a noteholder's request that the.... Wise use means the wise use of fisheries resources and their development, advancement, management...

  4. 27 CFR 46.253 - Destruction of articles by a Presidentially-declared major disaster.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Claims § 46...

  5. 42 CFR 84.253 - Chemical-cartridge respirators; requirements and tests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... cartridges or pairs of cartridges continuously at a concentration of 10 ppm vinyl chloride monomer at a total... respirator by a breathing machine at a concentration of 10 ppm vinyl chloride monomer at the rate of 24...

  6. 40 CFR 180.253 - Methomyl; tolerances for residues.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Asparagus 2 None Avocado 2 None Barley, grain 1 None Barley, hay 10 None Barley, straw 10 None Bean, dry, seed 0.1 None Bean, forage 10 None Bean, succulent 2 None Beet, garden, tops 6 None Bermudagrass...

  7. 40 CFR 180.253 - Methomyl; tolerances for residues.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Asparagus 2 None Avocado 2 None Barley, grain 1 None Barley, hay 10 None Barley, straw 10 None Bean, dry, seed 0.1 None Bean, forage 10 None Bean, succulent 2 None Beet, garden, tops 6 None Bermudagrass...

  8. 37 CFR 253.5 - Performance of musical compositions by public broadcasting entities licensed to colleges and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AND PROCEDURES USE OF CERTAIN COPYRIGHTED WORKS IN CONNECTION WITH NONCOMMERCIAL EDUCATIONAL... shall furnish to ASCAP, BMI and SESAC, upon request, a music-use report during one week of each calendar...

  9. Aerospace Medicine and Biology: 1983 cumulative index

    NASA Technical Reports Server (NTRS)

    1984-01-01

    This publication is a cumulative index to the abstracts contained in the Supplements 242 through 253 of Aerospace Medicine and Biology: A Continuing Bibliography. It includes six indexes--subject, personal author, corporate source, contract number, report number, and accession number.

  10. 27 CFR 46.253 - Destruction of articles by a Presidentially-declared major disaster.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Claims § 46...

  11. 27 CFR 46.253 - Destruction of articles by a Presidentially-declared major disaster.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Claims § 46...

  12. 27 CFR 46.253 - Destruction of articles by a Presidentially-declared major disaster.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Claims § 46...

  13. 27 CFR 46.253 - Destruction of articles by a Presidentially-declared major disaster.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MISCELLANEOUS REGULATIONS RELATING TO TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES Floor Stocks Tax on Certain Tobacco Products, Cigarette Papers, and Cigarette Tubes Held for Sale on April 1, 2009 Claims § 46...

  14. Topographic view of the Spring Creek Bridge and Collier State ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Topographic view of the Spring Creek Bridge and Collier State Park, view looking east. - Spring Creek Bridge, Spanning Spring Creek at Milepoint 253.98 on Oregon to California Highway (US Route 97), Chiloquin, Klamath County, OR

  15. Triple Scoop from Galaxy Hunter

    NASA Image and Video Library

    2006-07-28

    Located 10 million light-years away in the southern constellation Sculptor, the Silver Dollar galaxy, or NGC 253, is one of the brightest spiral galaxies in the night sky as seen in this edge-on view from NASA Galaxy Evolution Explorer.

  16. 50 CFR 253.50 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... enforcement. Fishery resource means finfish, mollusks, and crustaceans, and any form of marine or Great Lakes animal or plant life, including habitat, other than marine mammals and birds. Interjurisdictional fishery... Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

  17. 50 CFR 253.50 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... enforcement. Fishery resource means finfish, mollusks, and crustaceans, and any form of marine or Great Lakes animal or plant life, including habitat, other than marine mammals and birds. Interjurisdictional fishery... Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

  18. 50 CFR 253.50 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... enforcement. Fishery resource means finfish, mollusks, and crustaceans, and any form of marine or Great Lakes animal or plant life, including habitat, other than marine mammals and birds. Interjurisdictional fishery... Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

  19. 50 CFR 253.50 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... enforcement. Fishery resource means finfish, mollusks, and crustaceans, and any form of marine or Great Lakes animal or plant life, including habitat, other than marine mammals and birds. Interjurisdictional fishery... Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

  20. 30 CFR 253.26 - What information must I submit to support my unencumbered assets demonstration?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR... not be affected by an oil discharge from a COF. The assets must be plant, property, or equipment held...

  1. 30 CFR 253.26 - What information must I submit to support my unencumbered assets demonstration?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL SPILL FINANCIAL RESPONSIBILITY FOR OFFSHORE FACILITIES Methods for... list of reserved, unencumbered, and unimpaired U.S. assets whose value will not be affected by an oil...

  2. Resistance thermometer has linear resistance-temperature coefficient at low temperatures

    NASA Technical Reports Server (NTRS)

    Kuzyk, W.

    1966-01-01

    Resistance thermometer incorporating a germanium resistance element with a platinum resistance element in a wheatstone bridge circuit has a linear temperature-resistance coefficient over a range from approximately minus 140 deg C to approximately minus 253 deg C.

  3. 32 CFR 253.6 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... continuation of assignment is not clearly consistent with the national interest. (d) Completed security forms (DD Form 398, Personnel Security Questionnaire (BI/SBI), or 398-2, Personnel Security Questionnaire (National Agency Check)) shall be forwarded to the Defense Industrial Security Clearance Office (DISCO...

  4. 47 CFR 73.202 - Table of Allotments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Twentynine Palms 270A Wasco 224A Waterford 294A Westley *238A Willow Creek 253A Wofford Heights 251A COLORADO... Waitsburg 272A WEST VIRGINIA Glenville 299A Marlinton 292A St Marys *287A Wardensville 239A White Sulphur...

  5. Face Recognition From One Example View.

    DTIC Science & Technology

    1995-09-01

    Proceedings, International Workshop on Automatic Face- and Gesture-Recognition, pages 248{253, Zurich, 1995. [32] Yael Moses, Shimon Ullman, and Shimon...recognition. Journal of Cognitive Neuroscience, 3(1):71{86, 1991. [49] Shimon Ullman and Ronen Basri. Recognition by linear combinations of models

  6. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... of Agriculture, the Food and Nutrition Service (FNS) shall be responsible for the Food Distribution... commodities, (iv) Keep appropriate records and submit required reports, (v) Budget and account for...

  7. 7 CFR 253.11 - Administrative funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... fiscal year and apportionment of funds by the Office of Management and Budget, administrative funds will... receiving administrative funds, State agencies must submit a proposed budget reflecting planned...

  8. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... of Agriculture, the Food and Nutrition Service (FNS) shall be responsible for the Food Distribution... commodities, (iv) Keep appropriate records and submit required reports, (v) Budget and account for...

  9. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... of Agriculture, the Food and Nutrition Service (FNS) shall be responsible for the Food Distribution... commodities, (iv) Keep appropriate records and submit required reports, (v) Budget and account for...

  10. 7 CFR 253.11 - Administrative funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF... fiscal year and apportionment of funds by the Office of Management and Budget, administrative funds will... receiving administrative funds, State agencies must submit a proposed budget reflecting planned...

  11. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... of Agriculture, the Food and Nutrition Service (FNS) shall be responsible for the Food Distribution... commodities, (iv) Keep appropriate records and submit required reports, (v) Budget and account for...

  12. 7 CFR 253.7 - Certification of households.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM... formalized mechanisms to ensure ITO receipt of notices. (2) Food Distribution Program application form. The...

  13. 30 CFR 253.10 - What facilities does this part cover?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... granted under the OCSLA or applicable state law. (b) For a pipeline COF that extends onto land, this part applies to that portion of the pipeline lying seaward of the first accessible flow shut-off device on land. ...

  14. [Book Review] Building Models for Conservation and Wildlife Management, by A. M. Starfield and A. L. Bleloch

    USGS Publications Warehouse

    Johnson, D.H.

    1988-01-01

    Review of: Building Models for Conservation and Wildlife Management. By Anthony Starfield and A. L. Bleloch. New York: Macmillan; London: Collier Macmillan, 1986. ISBN: 002948040X. xi, 253 p.: ill.; 25 cm.

  15. 7 CFR 3550.253 - Settlement of a debt by compromise or adjustment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... or must have been accelerated by RHS. (2) Unsecured debts owed after the sale of the security... recovery value, and it is in the best interest of the Government to allow the debtor to retain the security...

  16. 7 CFR 3550.253 - Settlement of a debt by compromise or adjustment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... or must have been accelerated by RHS. (2) Unsecured debts owed after the sale of the security... recovery value, and it is in the best interest of the Government to allow the debtor to retain the security...

  17. 7 CFR 3550.253 - Settlement of a debt by compromise or adjustment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... or must have been accelerated by RHS. (2) Unsecured debts owed after the sale of the security... recovery value, and it is in the best interest of the Government to allow the debtor to retain the security...

  18. 7 CFR 3550.253 - Settlement of a debt by compromise or adjustment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... or must have been accelerated by RHS. (2) Unsecured debts owed after the sale of the security... recovery value, and it is in the best interest of the Government to allow the debtor to retain the security...

  19. 7 CFR 3550.253 - Settlement of a debt by compromise or adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... or must have been accelerated by RHS. (2) Unsecured debts owed after the sale of the security... recovery value, and it is in the best interest of the Government to allow the debtor to retain the security...

  20. 7 CFR 253.9 - Claims against households.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... separately liable for the repayment of the value of any overissuance of Food Distribution Program benefits to... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM...

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