Sample records for electron micros copy

  1. Electronic structure of the alkyne-bridged dicobalt hexacarbonyl complex Co(2) micro-C(2)H(2) (CO)(6): evidence for singlet diradical character and implications for metal-metal bonding.

    PubMed

    Platts, James A; Evans, Gareth J S; Coogan, Michael P; Overgaard, Jacob

    2007-08-06

    A series of ab initio calculations are presented on the alkyne-bridged dicobalt hexacarbonyl cluster Co2 micro-C2H2 (CO)6, indicating that this compound has substantial multireference character, which we interpret as evidence of singlet diradical behavior. As a result, standard theoretical methods such as restricted Hartree-Fock (RHF) or Kohn-Sham (RKS) density functional theory cannot properly describe this compound. We have therefore used complete active space (CAS) methods to explore the bonding in and spectroscopic properties of Co2 micro-C2H2 (CO)6. CAS methods identify significant population of a Co-Co antibonding orbital, along with Co-pi* back-bonding, and a relatively large singlet-triplet energy splitting. Analysis of the electron density and related quantities, such as energy densities and atomic overlaps, indicates a small but significant amount of covalent bonding between cobalt centers.

  2. Differentially expressed microRNAs in lung adenocarcinoma invert effects of copy number aberrations of prognostic genes

    PubMed Central

    Tokar, Tomas; Pastrello, Chiara; Ramnarine, Varune R.; Zhu, Chang-Qi; Craddock, Kenneth J.; Pikor, Larrisa A.; Vucic, Emily A.; Vary, Simon; Shepherd, Frances A.; Tsao, Ming-Sound; Lam, Wan L.; Jurisica, Igor

    2018-01-01

    In many cancers, significantly down- or upregulated genes are found within chromosomal regions with DNA copy number alteration opposite to the expression changes. Generally, this paradox has been overlooked as noise, but can potentially be a consequence of interference of epigenetic regulatory mechanisms, including microRNA-mediated control of mRNA levels. To explore potential associations between microRNAs and paradoxes in non-small-cell lung cancer (NSCLC) we curated and analyzed lung adenocarcinoma (LUAD) data, comprising gene expressions, copy number aberrations (CNAs) and microRNA expressions. We integrated data from 1,062 tumor samples and 241 normal lung samples, including newly-generated array comparative genomic hybridization (aCGH) data from 63 LUAD samples. We identified 85 “paradoxical” genes whose differential expression consistently contrasted with aberrations of their copy numbers. Paradoxical status of 70 out of 85 genes was validated on sample-wise basis using The Cancer Genome Atlas (TCGA) LUAD data. Of these, 41 genes are prognostic and form a clinically relevant signature, which we validated on three independent datasets. By meta-analysis of results from 9 LUAD microRNA expression studies we identified 24 consistently-deregulated microRNAs. Using TCGA-LUAD data we showed that deregulation of 19 of these microRNAs explains differential expression of the paradoxical genes. Our results show that deregulation of paradoxical genes is crucial in LUAD and their expression pattern is maintained epigenetically, defying gene copy number status. PMID:29507679

  3. Integrated Graphene-Based Optoelectronic Devices Used for Ultrafast Optical-THz Photodetectors, Modulators and Emitters

    DTIC Science & Technology

    2015-04-03

    08 and AFRL/ CA policy clarification memorandum dated 16 Jan 09. This report is available to the general public, including foreign nationals. Copies... doped graphene micro-ribbon array and a quantum-well electron gas sitting at an interface between a half-space of air and another half-space of a... doped semiconductor substrate which supports a surface-plasmon mode in our system. The coupling between a spatially-modulated total electromagnetic

  4. 77 FR 27125 - Periodicals-Recognition of Distribution of Periodicals via Electronic Copies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... Electronic Copies AGENCY: Postal Service\\TM\\. ACTION: Final rule. SUMMARY: The Postal Service will revise the... limited reporting of electronic copies of Periodicals publications to satisfy the circulation standards...--Recognition of Distribution of Periodicals via Electronic Copies (77 FR 5470-5471) revising DMM 707.6 by...

  5. 40 CFR 51.103 - Submission of plans, preliminary review of plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... State delivers five hard copies or at least two hard copies with an electronic version of the hard copy... an exact duplicate of the hard copy. (b) Upon request of a State, the Administrator will provide... hard copies or at least two hard copies with an electronic version of the hard copy (unless otherwise...

  6. 40 CFR 51.103 - Submission of plans, preliminary review of plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... State delivers five hard copies or at least two hard copies with an electronic version of the hard copy... an exact duplicate of the hard copy. (b) Upon request of a State, the Administrator will provide... hard copies or at least two hard copies with an electronic version of the hard copy (unless otherwise...

  7. 40 CFR 51.103 - Submission of plans, preliminary review of plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... State delivers five hard copies or at least two hard copies with an electronic version of the hard copy... an exact duplicate of the hard copy. (b) Upon request of a State, the Administrator will provide... hard copies or at least two hard copies with an electronic version of the hard copy (unless otherwise...

  8. 40 CFR 51.103 - Submission of plans, preliminary review of plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... State delivers five hard copies or at least two hard copies with an electronic version of the hard copy... an exact duplicate of the hard copy. (b) Upon request of a State, the Administrator will provide... hard copies or at least two hard copies with an electronic version of the hard copy (unless otherwise...

  9. 40 CFR 51.103 - Submission of plans, preliminary review of plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... State delivers five hard copies or at least two hard copies with an electronic version of the hard copy... an exact duplicate of the hard copy. (b) Upon request of a State, the Administrator will provide... hard copies or at least two hard copies with an electronic version of the hard copy (unless otherwise...

  10. Micro-Scale Genomic DNA Copy Number Aberrations as Another Means of Mutagenesis in Breast Cancer

    PubMed Central

    Chao, Hann-Hsiang; He, Xiaping; Parker, Joel S.; Zhao, Wei; Perou, Charles M.

    2012-01-01

    Introduction In breast cancer, the basal-like subtype has high levels of genomic instability relative to other breast cancer subtypes with many basal-like-specific regions of aberration. There is evidence that this genomic instability extends to smaller scale genomic aberrations, as shown by a previously described micro-deletion event in the PTEN gene in the Basal-like SUM149 breast cancer cell line. Methods We sought to identify if small regions of genomic DNA copy number changes exist by using a high density, gene-centric Comparative Genomic Hybridizations (CGH) array on cell lines and primary tumors. A custom tiling array for CGH (244,000 probes, 200 bp tiling resolution) was created to identify small regions of genomic change, which was focused on previously identified basal-like-specific, and general cancer genes. Tumor genomic DNA from 94 patients and 2 breast cancer cell lines was labeled and hybridized to these arrays. Aberrations were called using SWITCHdna and the smallest 25% of SWITCHdna-defined genomic segments were called micro-aberrations (<64 contiguous probes, ∼ 15 kb). Results Our data showed that primary tumor breast cancer genomes frequently contained many small-scale copy number gains and losses, termed micro-aberrations, most of which are undetectable using typical-density genome-wide aCGH arrays. The basal-like subtype exhibited the highest incidence of these events. These micro-aberrations sometimes altered expression of the involved gene. We confirmed the presence of the PTEN micro-amplification in SUM149 and by mRNA-seq showed that this resulted in loss of expression of all exons downstream of this event. Micro-aberrations disproportionately affected the 5′ regions of the affected genes, including the promoter region, and high frequency of micro-aberrations was associated with poor survival. Conclusion Using a high-probe-density, gene-centric aCGH microarray, we present evidence of small-scale genomic aberrations that can contribute to gene inactivation. These events may contribute to tumor formation through mechanisms not detected using conventional DNA copy number analyses. PMID:23284754

  11. Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction.

    PubMed

    Robinson, S; Follo, M; Haenel, D; Mauler, M; Stallmann, D; Tewari, M; Duerschmied, D; Peter, K; Bode, C; Ahrens, I; Hortmann, M

    2018-04-15

    micro-RNAs have shown promise as potential biomarkers for acute myocardial infarction and ischemia-reperfusion injury (I/R). Most recently droplet digital polymerase chain reaction (ddPCR) has been introduced as a more reliable and reproducible method for detecting micro-RNAs. We aimed to demonstrate the improved technical performance and diagnostic potential of ddPCR by measuring micro-RNAs in ST-elevation myocardial infarction (STEMI). A dilution series was performed in duplicate on synthetic Caenorrhabditis elegans-miR-39, comparing quantitative real-time PCR (qRT-PCR) and ddPCR. We used ddPCR and qRT-PCR to quantify the serum levels of miR-21, miR-208a and miR-499 between STEMI patients (n=24) and stable coronary artery disease (CAD) patients (n=20). In STEMI, I/R injury was assessed via measurement of ST-segment resolution. In the dilution series, ddPCR demonstrated superior coefficient of variation (12.1%vs.32.9%) and limit of detection (0.9325 vs.2.425copies/μl). In the patient cohort, ddPCR demonstrated greater differences in miR-21 levels (2190.5 vs. 484.7copies/μl; p=0.0004 for ddPCR and 136.4 vs. 122.8copies/μl; p=0.2273 for qRT-PCR) and in miR-208a (0 vs. 24.1copies/μl, p=0.0013 for ddPCR and 0 vs. 0copies/μl, p=0.0032 for qRT-PCR), with similar differences observed in miR-499 levels (9.4 vs. 81.5copies/μl, p<0.0001 for ddPCR and 0 vs. 19.41copies/μl, p<0.0001 for qRT-PCR). ddPCR also more accurately defined STEMI for all miRNAs (area under the curve (AUC) of 0.8021/0.7740/0.9063 for miR-21/208a/499 with ddPCR vs. AUC of 0.6083/0.6917/0.8417 with qRT-PCR). However, there was no association between miR-21/208a/499 levels and ischemia-reperfusion injury. ddPCR demonstrates superiority in both technical performance and diagnostic potential compared to qRT-PCR. Ultimately, this supports its use as a diagnostic method for quantifying micro-RNAs, particularly in large multi-center trials. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Quantification of Plasma miRNAs by Digital PCR for Cancer Diagnosis

    PubMed Central

    Ma, Jie; Li, Ning; Guarnera, Maria; Jiang, Feng

    2013-01-01

    Analysis of plasma microRNAs (miRNAs) by quantitative polymerase chain reaction (qPCR) provides a potential approach for cancer diagnosis. However, absolutely quantifying low abundant plasma miRNAs is challenging with qPCR. Digital PCR offers a unique means for assessment of nucleic acids presenting at low levels in plasma. This study aimed to evaluate the efficacy of digital PCR for quantification of plasma miRNAs and the potential utility of this technique for cancer diagnosis. We used digital PCR to quantify the copy number of plasma microRNA-21-5p (miR-21–5p) and microRNA-335–3p (miR-335–3p) in 36 lung cancer patients and 38 controls. Digital PCR showed a high degree of linearity and quantitative correlation with miRNAs in a dynamic range from 1 to 10,000 copies/μL of input, with high reproducibility. qPCR exhibited a dynamic range from 100 to 1×107 copies/μL of input. Digital PCR had a higher sensitivity to detect copy number of the miRNAs compared with qPCR. In plasma, digital PCR could detect copy number of both miR-21–5p and miR-335–3p, whereas qPCR was only able to assess miR-21–5p. Quantification of the plasma miRNAs by digital PCR provided 71.8% sensitivity and 80.6% specificity in distinguishing lung cancer patients from cancer-free subjects. PMID:24277982

  13. Temporal trends in postseroconversion CD4 cell count and HIV load: the Concerted Action on Seroconversion to AIDS and Death in Europe Collaboration, 1985-2002.

    PubMed

    Dorrucci, Maria; Rezza, Giovanni; Porter, Kholoud; Phillips, Andrew

    2007-02-15

    To determine whether early postseroconversion CD4 cell counts and human immunodeficiency virus (HIV) loads have changed over time. Our analysis was based on 22 cohorts of people with known dates of seroconversion from Europe, Australia, and Canada (Concerted Action on Seroconversion to AIDS and Death in Europe Collaboration). We focused on individuals seroconverting between 1985 and 2002 who had the first CD4 cell count (n=3687) or HIV load (n=1584) measured within 2 years of seroconversion and before antiretroviral use. Linear regression models were used to assess time trends in postseroconversion CD4 cell count and HIV load. Trends in time to key thresholds were also assessed, using survival analysis. The overall median initial CD4 cell count was 570 cells/ microL (interquartile range [IQR], 413-780 cells/ microL). The median initial HIV load was 35,542 copies/mL (IQR, 7600-153,050 copies/mL; on log(10) scale, 3.9-5.2 log(10) copies/mL). The postseroconversion CD4 cell count changed by an average of -6.33 cells/ microL/year (95% confidence interval [CI], -8.47 to -4.20 cells/ microL/year; P<.001), whereas an increase was observed in log(10) HIV load (+0.044 log(10) copies/mL/year; 95% CI, +0.034 to +0.053 log(10) copies/mL/year). These trends remained after adjusting for potential confounders. The probability of progressing to a CD4 cell count of <500 cells/ microL by 24 months from seroconversion increased from 0.66 (95% CI, 0.63-0.69) for individuals who seroconverted before 1991 to 0.80 (95% CI, 0.75-0.84) for those who seroconverted during 1999-2002. These data suggest that, in Europe, there has been a trend of decrease in the early CD4 cell count and of increase in the early HIV load. Additional research will be necessary to determine whether similar trends exist in other geographical areas.

  14. 7 CFR 1738.201 - Application submission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... applications must contain two hard copies and an electronic copy of the entire application. An application is considered received upon receipt of the hard and electronic copies by the National Office. The date and time...

  15. 7 CFR 1738.201 - Application submission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... applications must contain two hard copies and an electronic copy of the entire application. An application is considered received upon receipt of the hard and electronic copies by the National Office. The date and time...

  16. 7 CFR 1738.201 - Application submission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... applications must contain two hard copies and an electronic copy of the entire application. An application is considered received upon receipt of the hard and electronic copies by the National Office. The date and time...

  17. Use of FTA card for dry collection, transportation and storage of cervical cell specimen to detect high-risk HPV.

    PubMed

    Gustavsson, Inger; Lindell, Monica; Wilander, Erik; Strand, Anders; Gyllensten, Ulf

    2009-10-01

    The FTA elute micro card, which enable the collection, transport, and archiving of DNA could be an attractive alternative to a liquid based collection system for detection of human papillomavirus (HPV). To develop a method based on the FTA elute micro card for dry collection of cervical epithelial cell samples, suitable for subsequent PCR-based HPV testing. The method was evaluated by a comparison of the DNA collected by cytobrush and the regular FTA elute micro card from 50 cervical cell samples. The method was then used to estimate the DNA amount in 1040 samples applied to the indicating FTA elute micro card. The agreement in HPV positivity between the cytobrush and FTA samples (94%) was excellent (kappa=0.88, 95% CI 0.748-1). All the 1040 samples on the indicating FTA card had sufficient amounts of genomic DNA (>10 copies of a single copy gene) to be suitable for HPV typing. In 53 of the 1040 women the day in the menstrual cycle was noted, and the copy number during follicular phase day 9-13 was found to be statistically significantly lower than for the other three stages in the menstrual cycle (day 4-8, 14, >14) and during menopause. The indicating FTA elute micro card represents a suitable medium for collection of cervical cell samples, although follow-up studies are needed to verify the detection of low frequency HPV types.

  18. 22 CFR 503.9 - Electronic records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... electronically by accessing the BBG's Home Page via the Internet at http://www.ibb.gov. To set up an appointment to view such records in hard copy or to access the Internet via the BBG's computer, please contact... copying, both electronically via the Internet and in hard copy, those records that have been previously...

  19. 22 CFR 503.9 - Electronic records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... electronically by accessing the BBG's Home Page via the Internet at http://www.ibb.gov. To set up an appointment to view such records in hard copy or to access the Internet via the BBG's computer, please contact... copying, both electronically via the Internet and in hard copy, those records that have been previously...

  20. 22 CFR 503.9 - Electronic records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... electronically by accessing the BBG's Home Page via the Internet at http://www.ibb.gov. To set up an appointment to view such records in hard copy or to access the Internet via the BBG's computer, please contact... copying, both electronically via the Internet and in hard copy, those records that have been previously...

  1. 36 CFR 1225.24 - When can an agency apply previously approved schedules to electronic records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... may apply a previously approved schedule for hard copy records to electronic versions of the permanent records when the electronic records system replaces a single series of hard copy permanent records or the... have been previously scheduled as permanent in hard copy form, including special media records as...

  2. do_50mwind

    Science.gov Websites

    is not suitable for micro-siting potential development projects. This shapefile was generated from a "). The user is granted the right, without any fee or cost, to use, copy, modify, alter, enhance copies of the data. Further, the user of this data agrees to credit NREL in any publications or software

  3. 16 CFR 4.2 - Requirements as to form, and filing of documents other than correspondence.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Law Judge) or twelve (12) paper copies (if before the Commission), and an electronic copy in Adobe... an electronic copy on a compact disc (CD) or digital video disc (DVD) in Adobe portable document...

  4. 16 CFR 4.2 - Requirements as to form, and filing of documents other than correspondence.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Law Judge) or twelve (12) paper copies (if before the Commission), and an electronic copy in Adobe... an electronic copy on a compact disc (CD) or digital video disc (DVD) in Adobe portable document...

  5. Effect of Micro- and Nanomagnetite on Printing Toner Properties

    PubMed Central

    Ataeefard, Maryam; Ghasemi, Ebrahim; Ebadi, Mona

    2014-01-01

    Toner is a main component of electrophotographic printing and copying processes. One of the most important ingredients of toner is magnetite (Fe3O4) which provides the tribocharging property for toner particles. In this study, nano- and microparticles of Fe3O4 were synthesized using the coprecipitation method and different amounts of lauric acid as a surfactant. The synthesized nano and micro Fe3O4 was then used as the charge control agent to produce toner by emulsion aggregation. The Fe3O4 and toner were characterized by X-ray powder diffraction (XRD), atomic gradient force magnetometry (AGFM), dynamic laser scattering (DLS), particle size analysis, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The results show that the optimum amount of surfactant not only reduced particle size but also reduced the magnetite properties of Fe3O4. It was found that the magnetite behavior of the toner is not similar to the Fe3O4 used to produce it. Although small-sized Fe3O4 created toner with a smaller size, toners made with micro Fe3O4 showed better magnetite properties than toner made with nano Fe3O4. PMID:24574911

  6. 27 CFR 73.35 - Do I need to keep paper copies of forms I submit to TTB electronically?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURES AND PRACTICES ELECTRONIC SIGNATURES; ELECTRONIC SUBMISSION OF FORMS Electronic Filing of Documents with TTB § 73... unless TTB otherwise authorizes you to maintain electronic copies of these documents through a general...

  7. Micro-Plasticity of Genomes As Illustrated by the Evolution of Glutathione Transferases in 12 Drosophila Species

    PubMed Central

    Saisawang, Chonticha; Ketterman, Albert J.

    2014-01-01

    Glutathione transferases (GST) are an ancient superfamily comprising a large number of paralogous proteins in a single organism. This multiplicity of GSTs has allowed the copies to diverge for neofunctionalization with proposed roles ranging from detoxication and oxidative stress response to involvement in signal transduction cascades. We performed a comparative genomic analysis using FlyBase annotations and Drosophila melanogaster GST sequences as templates to further annotate the GST orthologs in the 12 Drosophila sequenced genomes. We found that GST genes in the Drosophila subgenera have undergone repeated local duplications followed by transposition, inversion, and micro-rearrangements of these copies. The colinearity and orientations of the orthologous GST genes appear to be unique in many of the species which suggests that genomic rearrangement events have occurred multiple times during speciation. The high micro-plasticity of the genomes appears to have a functional contribution utilized for evolution of this gene family. PMID:25310450

  8. 77 FR 5470 - Periodicals-Recognition of Distribution of Periodicals via Electronic Copies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Electronic Copies AGENCY: Postal Service TM . ACTION: Proposed rule. SUMMARY: The Postal Service proposes to....6, to allow publishers who use electronic distribution methods to report such circulation as paid or... publications through various electronic media channels. According to the standards that govern the Periodicals...

  9. 40 CFR 60.2260 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SOURCES Standards of Performance for Commercial and Industrial Solid Waste Incineration Units for Which... initial and annual opacity tests onsite in either paper copy or electronic format, unless the... as electronic or paper copy on or before the applicable submittal date. (f) Keep a copy of the...

  10. 40 CFR 60.2260 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SOURCES Standards of Performance for Commercial and Industrial Solid Waste Incineration Units for Which... initial and annual opacity tests onsite in either paper copy or electronic format, unless the... as electronic or paper copy on or before the applicable submittal date. (f) Keep a copy of the...

  11. 40 CFR 60.2260 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SOURCES Standards of Performance for Commercial and Industrial Solid Waste Incineration Units for Which... initial and annual opacity tests onsite in either paper copy or electronic format, unless the... as electronic or paper copy on or before the applicable submittal date. (f) Keep a copy of the...

  12. 30 CFR 585.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Installation Report? 585.702 Section 585.702 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... following items in your Fabrication and Installation Report: Required documents Required contents Other... electronic copy. (2) Schedule Fabrication and installation You must submit 1 paper copy and 1 electronic copy...

  13. 30 CFR 585.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Installation Report? 585.702 Section 585.702 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... following items in your Fabrication and Installation Report: Required documents Required contents Other... electronic copy. (2) Schedule Fabrication and installation You must submit 1 paper copy and 1 electronic copy...

  14. 30 CFR 585.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Installation Report? 585.702 Section 585.702 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... following items in your Fabrication and Installation Report: Required documents Required contents Other... electronic copy. (2) Schedule Fabrication and installation You must submit 1 paper copy and 1 electronic copy...

  15. 37 CFR Appendix A to Part 202 - Technical Guidelines Regarding Sound Physical Condition

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... excessive wear. B. Physical Appurtenances of Deposit Copy. 1. Physical Housing of Video Tape Copy. (a) In... generation copy from an edited master tape and must reproduce a flawless and consistent electronic signal... portions must reproduce a flawless and consistent electronic signal without any audible defects. (17 U.S.C...

  16. 37 CFR Appendix A to Part 202 - Technical Guidelines Regarding Sound Physical Condition

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... excessive wear. B. Physical Appurtenances of Deposit Copy. 1. Physical Housing of Video Tape Copy. (a) In... generation copy from an edited master tape and must reproduce a flawless and consistent electronic signal... portions must reproduce a flawless and consistent electronic signal without any audible defects. (17 U.S.C...

  17. Studies in Intelligence. Volume 49, Number 3, 2005

    DTIC Science & Technology

    2005-01-01

    variety of other technologies. Working from a makeshift micro - film studio in a Greenwich Vil- lage apartment, they copied and turned over to Soviet...lectured Khrush- chev on the potential for micro - electronics—a word he had introduced into the Russian lan- guage—to transform industry. The new... micro - manage SIS affairs. He effected his liaison with Hoover through State’s Division of Foreign Activ- ity Correlation (FC).43 In addi- 41 In

  18. Micro-droplet Digital Polymerase Chain Reaction and Real-Time Quantitative Polymerase Chain Reaction Technologies Provide Highly Sensitive and Accurate Detection of Zika Virus.

    PubMed

    Hui, Yuan; Wu, Zhiming; Qin, Zhiran; Zhu, Li; Liang, Junhe; Li, Xujuan; Fu, Hanmin; Feng, Shiyu; Yu, Jianhai; He, Xiaoen; Lu, Weizhi; Xiao, Weiwei; Wu, Qinghua; Zhang, Bao; Zhao, Wei

    2018-06-01

    The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus (ZIKV) and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction (ddPCR) and real-time quantitative PCR (RT-qPCR) protocols for the detection of ZIKV based on the amplification of the NS5 gene. For the ZIKV standard plasmid, the RT-qPCR results showed that the cycle threshold (Ct) value was linear from 10 1 to 10 8  copy/μL, with a standard curve R 2 of 0.999 and amplification efficiency of 92.203%; however, a concentration as low as 1 copy/μL could not be detected. In comparison with RT-qPCR, the ddPCR method resulted in a linear range of 10 1 -10 4  copy/μL and was able to detect concentrations as low as 1 copy/μL. Thus, for detecting ZIKV from clinical samples, RT-qPCR is a better choice for high-concentration samples (above 10 1  copy/μL), while ddPCR has excellent accuracy and sensitivity for low-concentration samples. These results indicate that the ddPCR method should be of considerable use in the early diagnosis, laboratory study, and monitoring of ZIKV.

  19. 17 CFR 147.9 - Requests for copies of transcripts, recordings or minutes of closed meetings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., recordings or minutes of closed meetings. (a) Copies of a transcript transcription of an electronic recording... § 147.8(a), shall be furnished to any person at the actual cost of duplication or transcription pursuant...)(9), (d) and (e). (b) Requests for copies of transcripts, transcriptions of electronic recordings or...

  20. 17 CFR 147.9 - Requests for copies of transcripts, recordings or minutes of closed meetings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., recordings or minutes of closed meetings. (a) Copies of a transcript transcription of an electronic recording... § 147.8(a), shall be furnished to any person at the actual cost of duplication or transcription pursuant...)(9), (d) and (e). (b) Requests for copies of transcripts, transcriptions of electronic recordings or...

  1. Cloning and expression of vgb gene in Bacillus cereus, improve phenol and p-nitrophenol biodegradation

    NASA Astrophysics Data System (ADS)

    Vélez-Lee, Angel Eduardo; Cordova-Lozano, Felipe; Bandala, Erick R.; Sanchez-Salas, Jose Luis

    2016-02-01

    In this work, the vgb gene from Vitrocilla stercoraria was used to genetically modify a Bacillus cereus strain isolated from pulp and paper wastewater effluent. The gene was cloned in a multicopy plasmid (pUB110) or uni-copy gene using a chromosome integrative vector (pTrpBG1). B. cereus and its recombinant strains were used for phenol and p-nitrophenol biodegradation using aerobic or micro-aerobic conditions and two different temperatures (i.e. 37 and 25 °C). Complete (100%) phenol degradation was obtained for the strain where the multicopy of vgb gene was present, 98% for the strain where uni-copy gene was present and 45% for wild type strain for the same experimental conditions (i.e. 37 °C and aerobic condition). For p-nitrophenol degradation at the same conditions, the strain with the multi-copy vgb gene was capable to achieve 50% of biodegradation, ˜100% biodegradation was obtained using the uni-copy strain and ˜24% for wild type strain. When the micro-aerobic condition was tested, the biodegradation yield showed a significant decreased. The biodegradation trend observed for aerobic was similar for micro-aerobic assessments: the modified strains showed higher degradation rates when compared with wild type strain. For all experimental conditions, the highest p-nitrophenol degradation was observed using the strain with uni-copy of vgb gene. Besides the increase of biodegradative capability of the strain, insertion of the vgb gene was observed able to modify other morphological characteristics such as avoiding the typical flake formation in the B. cereus culture. In both cases, the modification seems to be related with the enhancement of oxygen supply to the cells generated by the vgb gene insertion. The application of the genetically modified microorganism (GMM) to the biodegradation of pollutants in contaminated water possesses high potential as an environmentally friendly technology to facing this emergent problem.

  2. 40 CFR 263.20 - The manifest system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... accompany a hazardous waste shipment is satisfied when a copy of an electronic manifest is accessible during... CFR 177.817, a hazardous waste transporter must carry one printed copy of the electronic manifest on... unavailable for any reason, then: (i) The transporter in possession of the hazardous waste when the electronic...

  3. 76 FR 35859 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... deleting and shredding paper copies. Registers are destroyed by electronic deletion 40 years after the date... electronically deleting and shredding paper copies. Registers are destroyed by electronic deletion 40 years after...) is used to authenticate and lock out unauthorized access. Paper records are maintained in locked file...

  4. Evolution of the human-specific microRNA miR-941

    PubMed Central

    Hu, Hai Yang; He, Liu; Fominykh, Kseniya; Yan, Zheng; Guo, Song; Zhang, Xiaoyu; Taylor, Martin S.; Tang, Lin; Li, Jie; Liu, Jianmei; Wang, Wen; Yu, Haijing; Khaitovich, Philipp

    2012-01-01

    MicroRNA-mediated gene regulation is important in many physiological processes. Here we explore the roles of a microRNA, miR-941, in human evolution. We find that miR-941 emerged de novo in the human lineage, between six and one million years ago, from an evolutionarily volatile tandem repeat sequence. Its copy-number remains polymorphic in humans and shows a trend for decreasing copy-number with migration out of Africa. Emergence of miR-941 was accompanied by accelerated loss of miR-941-binding sites, presumably to escape regulation. We further show that miR-941 is highly expressed in pluripotent cells, repressed upon differentiation and preferentially targets genes in hedgehog- and insulin-signalling pathways, thus suggesting roles in cellular differentiation. Human-specific effects of miR-941 regulation are detectable in the brain and affect genes involved in neurotransmitter signalling. Taken together, these results implicate miR-941 in human evolution, and provide an example of rapid regulatory evolution in the human linage. PMID:23093182

  5. 15 CFR 700.13 - Acceptance and rejection of rated orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... order and transmit the acceptance or rejection in writing (hard copy), or in electronic format, within... rejection, pursuant to paragraphs (b) and (c) of this section, in writing (hard copy) or electronic format...

  6. 77 FR 49834 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... provide copies of licensee nuclear material event reports electronically or by hard copy to the NRC within... event information should be provided in a uniform electronic format, for assessment and identification...

  7. 29 CFR 1209.08 - Transcripts, recordings or minutes of closed meetings; retention; public availability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provisions of 5 U.S.C. 552b(c), copies of transcripts or minutes, or transcriptions of electronic recordings... transcription. Requests for copies of transcripts or minutes, or transcriptions of electronic recordings of...

  8. 76 FR 3584 - Time for Payment of Certain Excise Taxes, and Quarterly Excise Tax Payments for Small Alcohol...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... 40 Cigars and cigarettes, Claims, Electronic fund transfers, Excise taxes, Labeling, Packaging and..., Regulations.gov , we will post, and you may view, copies of this notice, any electronic or mailed comments we... material that we consider unsuitable for posting. You also may view copies of this notice, any electronic...

  9. Comparison of medical students' learning approaches between electronic and hard copy team-based learning.

    PubMed

    Sharaf, Fawzy; Alnohair, Sultan

    2017-01-01

    To compare the students' perception of team-based learning (TBL): The paper (hard copy) compared with the e-copy (electronic copy) in the family medicine course of the fifth year medical students, Qassim University College of Medicine. A cross-sectional study was conducted during the family medicine course in 2015-2016 to compare the hard copy and the e-copy TBL sessions. We used Google drive to distribute, collect and analyze the questionnaire. The results of the e-copy TBL are shown and displayed directly with each session to the students, which was not the same as practiced with hard copy. We used also SPSS (version 17 for Windows) for more statistical analysis. The total number of respondents of students in each was 96; a phase of TBL phase 1 (hard copy) and phase 2 (e-copy). Male were 64 (66.7%) and females 32 (33.3%). The first three knowledge questions showed no difference between the mean score between paper and e-copy TBL, but of the perception questions showed a significant difference between the paper and e-copy TBL. The results of the survey showed that the students prefer e-copy TBL as a course format, as it was an attraction for most of the students and making them even more successful in the key exam and e-copy TBL develop the skills needed to work productively in task-groups.

  10. 77 FR 65448 - Funding Availability Under Supportive Services for Veteran Families Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ... electronic copy of the entire application. A budget template must be attached in Excel format on the CD, but... contain an electronic copy of the entire application. A budget template must be attached in Excel format...

  11. Problems at the Leading Edge of Space Weathering as Revealed by TEM Combined with Surface Science Techniques

    NASA Technical Reports Server (NTRS)

    Christoffersen, R.; Dukes, C. A.; Keller, L. P.; Rahman, Z.; Baragiola, R. A.

    2015-01-01

    Both transmission electron micros-copy (TEM) and surface analysis techniques such as X-ray photoelectron spectroscopy (XPS) were instrumen-tal in making the first characterizations of material generated by space weathering in lunar samples [1,2]. Without them, the nature of nanophase metallic Fe (npFe0) correlated with the surface of lunar regolith grains would have taken much longer to become rec-ognized and understood. Our groups at JSC and UVa have been using both techniques in a cross-correlated way to investigate how the solar wind contributes to space weathering [e.g., 3]. These efforts have identified a number of ongoing problems and knowledge gaps. Key insights made by UVa group leader Raul Barag-iola during this work are gratefully remembered.

  12. Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40

    PubMed Central

    McNees, Adrienne L.; Harrigal, Lindsay J.; Kelly, Aoife; Minard, Charles G.; Wong, Connie

    2018-01-01

    Background Polyomaviruses, including simian virus 40 (SV40), display evidence of lymphotropic properties. This study analyzed the nature of SV40–human lymphocyte interactions in established cell lines and in primary lymphocytes. The effects of viral microRNA and the structure of the viral regulatory region on SV40 persistence were examined. Results SV40 DNA was maintained in infected B cell and myeloid cell lines during cell growth for at least 28 days. Limiting dilution analysis showed that low amounts of SV40 DNA (~2 copies per cell) were retained over time. Infected B cells remained viable and able to proliferate. Genome copies of the SV40 microRNA-null mutant persisted at higher levels than the DNA of wild-type viruses. Complex viral regulatory regions produced modestly higher DNA levels than simple regulatory regions. Viral large T-antigen protein was detected at low frequency and at low levels in infected B cells. Following infection of primary lymphocytes, SV40 DNA was detected in CD19+ B cells and CD14+ monocytes, but not in CD3+ T cells. Rescue attempts using either lysates of SV40-infected B lymphocytes, coculture of live cells, or infectious center assays all showed that replication-competent SV40 could be recovered on rare occasions. SV40 infections altered the expression of several B cell surface markers, with more pronounced changes following infections with the microRNA-null mutant. Conclusion These findings indicate that SV40 can establish persistent infections in human B lymphocytes. The cells retain low copy numbers of viral DNA; the infections are nonproductive and noncytolytic but can occasionally produce infectious virus. SV40 microRNA negatively regulates the degree of viral effects on B cells. Significance Lymphocytes may serve as viral reservoirs and may function to disseminate polyomaviruses to different tissues in a host. To our knowledge, this report is the first extensive analysis of viral microRNA effects on SV40 infection of human lymphocytes. PMID:29432481

  13. 49 CFR 512.5 - How many copies should I submit?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... must send the following in hard copy or electronic format to the Chief Counsel when making a claim for... format, a copy of any special software required to review materials for which confidential treatment is...

  14. Imaging Prostate Cancer Microenvironment by Collagen Hybridization

    DTIC Science & Technology

    2013-10-01

    There is an emerging concept of using non-cellular solid state compartment as a source for therapeutic targets and for selective imaging of micro ... using second harmonic generation and two-photon micros - copy. J. Biomed. Opt. 14, 044013. Bioconjugate Chemistry Communication dx.doi.org/10.1021...Chiu WC, Lai CC, Liou GG, Li HC, Chou MY: Production of multivalent protein binders using a self- trimerizing collagen-like peptide scaffold. FASEB J

  15. Nonenzymatic microorganism identification based on ribosomal RNA

    NASA Astrophysics Data System (ADS)

    Ives, Jeffrey T.; Pierini, Alicia M.; Stokes, Jeffrey A.; Wahlund, Thomas M.; Read, Betsy; Bechtel, James H.; Bronk, Burt V.

    1999-11-01

    Effective defense against biological warfare (BW) agents requires rapid, fieldable and accurate systems. For micro- organisms like bacteria and viruses, ribosomal RNA (rRNA) provides a valuable target with multiple advantages of species specificity and intrinsic target amplification. Vegetative and spore forms of bacteria contain approximately 104 copies of rRNA. Direct detection of rRNA copies can eliminate some of the interference and preparation difficulties involved in enzymatic amplification methods. In order to apply the advantages of rRNA to BW defense, we are developing a fieldable system based on 16S rRNA, physical disruption of the micro-organism, solid phase hybridization, and fluorescence detection. Our goals include species-specific identification, complete operation from raw sample to identification in 15 minutes or less, and compact, fieldable instrumentation. Initial work on this project has investigated the lysis and hybridization steps, the species-specificity of oligonucleotides probes, and the development of a novel electromagnetic method to physically disrupt the micro- organisms. Target bacteria have been Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis). Continuing work includes further development of methods to rapidly disrupt the micro-organisms and release the rRNA, improved integration and processing, and extension to bacterial and mammalian viruses like MS2 and vesicular stomatitis virus.

  16. 46 CFR 535.701 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., Washington, DC 20573-0001. A copy of the Monitoring Report form in Microsoft Word and Excel format may be... Monitoring Reports in the Commission's prescribed electronic format, either on diskette or CD-ROM. (e)(1) The... filed by this subpart may be filed by direct electronic transmission in lieu of hard copy. Detailed...

  17. 12 CFR 620.10 - Preparing the quarterly report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 620.10 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DISCLOSURE TO SHAREHOLDERS... must: (1) Prepare and send, to the Farm Credit Administration, an electronic copy of its quarterly...) Publish a copy of its quarterly report on its Web site when it electronically sends the report to the Farm...

  18. Association of MicroRNAs with Antibody Response to Mycoplasma bovis in Beef Cattle

    PubMed Central

    Cai, Guohong; Kuehn, Larry A.; Register, Karen B.; McDaneld, Tara G.; Neill, John D.

    2016-01-01

    The objective of this study was to identify microRNAs associated with a serum antibody response to Mycoplasma bovis in beef cattle. Serum from sixteen beef calves was collected at three points: in summer after calves were born, in fall at weaning, and in the following spring. All sera collected in the summer were ELISA-negative for anti-M. bovis. By the fall, eight animals were seropositive for IgG (positive group), while eight remained negative (negative group). By spring, all animals in both groups were seropositive. MicroRNAs were extracted from sera and sequenced on the Illumina HiSeq next-generation sequencer. A total of 1,374,697 sequences mapped to microRNAs in the bovine genome. Of these, 82% of the sequences corresponded to 27 microRNAs, each represented by a minimum of 10,000 sequences. There was a statistically significant interaction between ELISA response and season for bta-miR-24-3p (P = 0.0268). All sera collected at the initial summer had a similar number of copies of this microRNA (P = 0.773). In the fall, the positive group had an increased number of copies when compared to the negative group (P = 0.021), and this grew more significant by the following spring (P = 0.0001). There were 21 microRNAs associated (P< 0.05) with season. These microRNAs could be evaluated further as candidates to potentially improve productivity in cattle. The microRNAs bta-let-7b, bta-miR- 24-3p, bta-miR- 92a, and bta-miR-423-5p, were significatly associated with ELISA status (P< 0.05). These microRNAs have been recognized as playing a role in the host defense against bacteria in humans, mice, and dairy cattle. Further studies are needed to establish if these microRNAs could be used as diagnostic marker or indicator of exposure, or whether intervention strategies could be developed as an alternative to antibiotics for controlling disease due to M. bovis. PMID:27537842

  19. Surveillance for Enteric Pathogens in a Case-Control Study of Acute Diarrhea in Western Kenya

    DTIC Science & Technology

    2012-11-01

    isolates was ascertained using the MicroScan WalkAway 40 Plus. An enzyme immunoassay kit was used to detect rotavirus , and ova and parasite...examination was conducted by micros- copy and an enzyme immunoassay. Results: Rotavirus (10.2% and 10.5%) and Shigella (11% and 8%) were isolated significantly...Keywords: Gastroenteritis, Protozoa, Rotavirus , Shigella, Escherichia coli, Antimicrobial resistance Introduction Diarrheal disease continues to be a

  20. GP trainees' in-consultation information-seeking: associations with human, paper and electronic sources.

    PubMed

    Magin, Parker; Morgan, Simon; Wearne, Susan; Tapley, Amanda; Henderson, Kim; Oldmeadow, Chris; Ball, Jean; Scott, John; Spike, Neil; McArthur, Lawrie; van Driel, Mieke

    2015-10-01

    Answering clinical questions arising from patient care can improve that care and offers an opportunity for adult learning. It is also a vital component in practising evidence-based medicine. GPs' sources of in-consultation information can be human or non-human (either hard copy or electronic). To establish the prevalence and associations of GP trainees' in-consultation information-seeking, and to establish the prevalence of use of different sources of information (human, hard copy and electronic) and the associations of choosing particular sources. A cross-sectional analysis of data (2010-13) from an ongoing cohort study of Australian GP trainees' consultations. Once each 6-month training term, trainees record detailed data of 60 consecutive consultations. The primary outcome was whether the trainee sought in-consultation information for a problem/diagnosis. Secondary outcomes were whether information-seeking was from a human (GP, other specialist or other health professional) or from a non-human source (electronic or hard copy), and whether a non-human source was electronic or hard copy. Six hundred forty-five trainees (response rate 94.3%) contributed data for 84,723 consultations including 131,583 problems/diagnoses. In-consultation information was sought for 15.4% (95% confidence interval=15.3-15.6) of problems/diagnoses. Sources were: GP in 6.9% of problems/diagnoses, other specialists 0.9%, other health professionals 0.6%, electronic sources 6.5% and hard-copy sources 1.5%. Associations of information-seeking included younger patient age, trainee full-time status and earlier training stage, longer consultation duration, referring the patient, organizing follow-up and generating learning goals. Associations of choosing human information sources (over non-human sources) were similar, but also included the trainee's training organization. Associations of electronic rather than hard-copy information-seeking included the trainee being younger, the training organization and information-seeking for management rather than diagnosis. Trainee information-seeking is mainly from GP colleagues and electronic sources. Human information-sources are preferentially sought for more complex problems, even by these early-career GPs who have trained in the 'internet era'. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. 76 FR 28027 - State Program Requirements; Application for Program Revision to the National Pollutant Discharge...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... copies to Hanh Shaw, Office of Water and Watersheds, Mail Stop OWW-130, 1200 Sixth Avenue, Suite 900, Seattle, WA 98101-3140. E-mail: Send electronic copies to shaw[email protected] . Fax: Fax copies to the attention of Hanh Shaw at (206) 553-0165. Hand Delivery/Courier: Deliver copies to Hanh Shaw, Office of...

  2. 40 CFR 60.2260 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SOURCES Standards of Performance for Commercial and Industrial Solid Waste Incineration Units Air Curtain... paper copy or electronic format, unless the Administrator approves another format, for at least 5 years...) Submit initial and annual opacity test reports as electronic or paper copy on or before the applicable...

  3. 40 CFR 60.2260 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SOURCES Standards of Performance for Commercial and Industrial Solid Waste Incineration Units Air Curtain... paper copy or electronic format, unless the Administrator approves another format, for at least 5 years...) Submit initial and annual opacity test reports as electronic or paper copy on or before the applicable...

  4. 40 CFR 60.2870 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SOURCES Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration... records of results of all initial and annual opacity tests onsite in either paper copy or electronic... annual opacity test reports as electronic or paper copy on or before the applicable submittal date and...

  5. 40 CFR 60.2870 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SOURCES Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration... onsite in either paper copy or electronic format, unless the Administrator approves another format, for... the previous report. (e) Submit initial and annual opacity test reports as electronic or paper copy on...

  6. 40 CFR 60.2870 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SOURCES Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration... records of results of all initial and annual opacity tests onsite in either paper copy or electronic... annual opacity test reports as electronic or paper copy on or before the applicable submittal date and...

  7. 40 CFR 60.2870 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SOURCES Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration... onsite in either paper copy or electronic format, unless the Administrator approves another format, for... report. (e) Submit initial and annual opacity test reports as electronic or paper copy on or before the...

  8. 40 CFR 60.2870 - What are the recordkeeping and reporting requirements for air curtain incinerators?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SOURCES Emissions Guidelines and Compliance Times for Commercial and Industrial Solid Waste Incineration... onsite in either paper copy or electronic format, unless the Administrator approves another format, for... report. (e) Submit initial and annual opacity test reports as electronic or paper copy on or before the...

  9. 75 FR 12315 - Pacific Gas and Electric Company; Diablo Canyon Independent Spent Fuel Storage Installation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... cases to mail copies on electronic storage media. Participants may not submit paper copies of their... holidays. Participants who believe that they have a good cause for not submitting documents electronically..., such as social security numbers, home addresses, or home phone numbers in their filings, unless an NRC...

  10. Window-assisted nanosphere lithography for vacuum micro-nano-electronics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Nannan; Institute of Electronic Engineering, Chinese Academy of Engineering Physics, Mianyang, 621900; Pang, Shucai

    2015-04-15

    Development of vacuum micro-nano-electronics is quite important for combining the advantages of vacuum tubes and solid-state devices but limited by the prevailing fabricating techniques which are expensive, time consuming and low-throughput. In this work, window-assisted nanosphere lithography (NSL) technique was proposed and enabled the low-cost and high-efficiency fabrication of nanostructures for vacuum micro-nano-electronic devices, thus allowing potential applications in many areas. As a demonstration, we fabricated high-density field emitter arrays which can be used as cold cathodes in vacuum micro-nano-electronic devices by using the window-assisted NSL technique. The details of the fabricating process have been investigated. This work provided amore » new and feasible idea for fabricating nanostructure arrays for vacuum micro-nano-electronic devices, which would spawn the development of vacuum micro-nano-electronics.« less

  11. Commercial Dairy Cow Milk microRNAs Resist Digestion under Simulated Gastrointestinal Tract Conditions.

    PubMed

    Benmoussa, Abderrahim; Lee, Chan Ho C; Laffont, Benoit; Savard, Patricia; Laugier, Jonathan; Boilard, Eric; Gilbert, Caroline; Fliss, Ismail; Provost, Patrick

    2016-11-01

    MicroRNAs are small, gene-regulatory noncoding RNA species present in large amounts in milk, where they seem to be protected against degradative conditions, presumably because of their association with exosomes. We monitored the relative stability of commercial dairy cow milk microRNAs during digestion and examined their associations with extracellular vesicles (EVs). We used a computer-controlled, in vitro, gastrointestinal model TNO intestinal model-1 (TIM-1) and analyzed, by quantitative polymerase chain reaction, the concentration of 2 microRNAs within gastrointestinal tract compartments at different points in time. EVs within TIM-1 digested and nondigested samples were studied by immunoblotting, dynamic light scattering, quantitative polymerase chain reaction, and density measurements. A large quantity of dairy milk Bos taurus microRNA-223 (bta-miR-223) and bta-miR-125b (∼10 9 -10 10 copies/300 mL milk) withstood digestion under simulated gastrointestinal tract conditions, with the stomach causing the most important decrease in microRNA amounts. A large quantity of these 2 microRNAs (∼10 8 -10 9 copies/300 mL milk) was detected in the upper small intestine compartments, which supports their potential bioaccessibility. A protocol optimized for the enrichment of dairy milk exosomes yielded a 100,000 × g pellet fraction that was positive for the exosomal markers tumor susceptibility gene-101 (TSG101), apoptosis-linked gene 2-interacting protein X (ALIX), and heat shock protein 70 (HSP70) and containing bta-miR-223 and bta-miR-125b. This approach, based on successive ultracentrifugation steps, also revealed the existence of ALIX - , HSP70 -/low , and TSG101 -/low EVs larger than exosomes and 2-6 times more enriched in bta-miR-223 and bta-miR-125b (P < 0.05). Our findings indicate that commercial dairy cow milk contains numerous microRNAs that can resist digestion and are associated mostly with ALIX - , HSP70 -/low , and TSG101 -/low EVs. Our results support the existence of interspecies transfer of microRNAs mediated by milk consumption and challenge our current view of exosomes as the sole carriers of milk-derived microRNAs. © 2016 American Society for Nutrition.

  12. Compact quadruple therapy with the lamivudine/zidovudine combination tablet plus abacavir and efavirenz, followed by the lamivudine/zidovudine/abacavir triple nucleoside tablet plus efavirenz in treatment-naïve HIV-infected adults.

    PubMed

    Ruane, Peter J; Parenti, David M; Margolis, David M; Shepp, David H; Babinchak, Timothy J; Van Kempen, Amy S; Kauf, Teresa L; Danehower, Susan A; Yau, Linda; Hessenthaler, Siegrid M; Goodwin, Diane; Hernandez, Jaime E

    2003-01-01

    To assess efficacy, safety, and adherence with compact quadruple therapy comprising one lamivudine 150-mg/zidovudine 300-mg tablet (COM) twice daily + one abacavir (ABC) 300-mg tablet twice daily + three efavirenz (EFV) 200-mg capsules at bedtime for 24 weeks, followed by one lamivudine 150-mg/zidovudine 300-mg/ABC 300-mg triple nucleoside tablet (TZV) twice daily + three EFV 200-mg capsules at bedtime for 24 weeks. A pilot 48-week, prospective, open-label trial in which 38 antiretroviral-naïve HIV-infected adults (baseline median HIV-1 RNA 5.1 log(10) copies/mL, CD4+ cell count 285/microL) received the above treatment and were monitored regularly with respect to plasma HIV-1 RNA levels, CD4+ cell counts, T-cell receptor excision circles (TRECs), adherence, and adverse events. At Week 48, intent-to-treat, switch-included analysis showed plasma HIV-1 RNA levels <400 copies/mL in 100% (29/29) of patients and <50 copies/mL in 93% (27/29); 59% of patients who achieved <50 copies/mL had <3 copies/mL (16/27). Similar virologic suppression was observed in patients with baseline HIV-1 RNA above or below 100000 copies/mL. HIV-1 RNA and CD4+ cell counts changed from baseline by a median of -3.4 log(10) copies/mL and +172 cells/microL, respectively. One virologic failure occurred at Week 16. Median TRECs/100000 peripheral blood lymphocytes increased 6-fold between baseline and Week 48. Median adherence rates were consistently 100% by self-report and 94% by pill count. Grade 2-4 treatment-related adverse events included dreams (16%), nausea (13%), decreased white cells (8%), dizziness (8%), sleep disorders (8%), and malaise and fatigue (8%). A suspected ABC hypersensitivity reaction occurred in 8% (3/38) of patients. COM/ABC/EFV or TZV/EFV produced potent, durable virologic suppression and immunologic benefits, was associated with high adherence rates, and was generally well tolerated.

  13. 32 CFR 989.14 - Environmental assessment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... format for the EA may be the same as the EIS. The alternatives section of an EA and an EIS are similar... Alternative (FONPA) must be submitted (five hard copies and an electronic version) to the MAJCOM EPF when the... submitted (five hard copies and an electronic version) through the MAJCOM EPF to HQ USAF/A7CI for SAF/IEE...

  14. 7 CFR 400.712 - Research and development reimbursement, maintenance reimbursement, and user fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Documentation of actual costs allowed under this section will be used to determine any reimbursement. (c) To be... requested, and all supporting documentation, must be submitted to FCIC by electronic method or by hard copy... supporting documentation, must be submitted to FCIC by electronic method or by hard copy and received by FCIC...

  15. 7 CFR 400.712 - Research and development reimbursement, maintenance reimbursement, and user fees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Documentation of actual costs allowed under this section will be used to determine any reimbursement. (c) To be... requested, and all supporting documentation, must be submitted to FCIC by electronic method or by hard copy... supporting documentation, must be submitted to FCIC by electronic method or by hard copy and received by FCIC...

  16. 7 CFR 400.712 - Research and development reimbursement, maintenance reimbursement, and user fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Documentation of actual costs allowed under this section will be used to determine any reimbursement. (c) To be... requested, and all supporting documentation, must be submitted to FCIC by electronic method or by hard copy... supporting documentation, must be submitted to FCIC by electronic method or by hard copy and received by FCIC...

  17. 75 FR 32341 - Import Administration IA ACCESS Pilot Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... submitted electronically need not also be submitted in hard copy. Persons wishing to submit written comments in hard copy should file one signed original and two copies of each set of comments to the address... . Any questions concerning file formatting, document conversion, access on the Internet, or other...

  18. 18 CFR 33.8 - Number of copies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATIONS UNDER FEDERAL POWER ACT SECTION 203 § 33.8 Number of copies. An original and eight copies of the application under this part must be submitted. If..., the applicant must submit all such information in electronic format (e.g., on computer diskette or on...

  19. 33 CFR 401.90 - Boarding for inspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., or for the purpose of making copies or extracts, any log book, document or paper; and (2) In carrying... copying equipment in the vessel to make copies of any books, records, electronic data or other documents... practices and procedures that the officer may reasonably require. (d) Vessels shall provide a safe and...

  20. A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy.

    PubMed

    Farr, Ryan J; Januszewski, Andrzej S; Joglekar, Mugdha V; Liang, Helena; McAulley, Annie K; Hewitt, Alex W; Thomas, Helen E; Loudovaris, Tom; Kay, Thomas W H; Jenkins, Alicia; Hardikar, Anandwardhan A

    2015-06-02

    MicroRNAs are now increasingly recognized as biomarkers of disease progression. Several quantitative real-time PCR (qPCR) platforms have been developed to determine the relative levels of microRNAs in biological fluids. We systematically compared the detection of cellular and circulating microRNA using a standard 96-well platform, a high-content microfluidics platform and two ultra-high content platforms. We used extensive analytical tools to compute inter- and intra-run variability and concordance measured using fidelity scoring, coefficient of variation and cluster analysis. We carried out unprejudiced next generation sequencing to identify a microRNA signature for Diabetic Retinopathy (DR) and systematically assessed the validation of this signature on clinical samples using each of the above four qPCR platforms. The results indicate that sensitivity to measure low copy number microRNAs is inversely related to qPCR reaction volume and that the choice of platform for microRNA biomarker validation should be made based on the abundance of miRNAs of interest.

  1. 75 FR 52940 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Chartered Science...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... should be supplied to the DFO in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, MS Word, WordPerfect, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to provide electronic...

  2. It's Not Easy Being Green: A Survey of Staff Experiences with Environmental Issues in Sci-Tech and Other Libraries.

    ERIC Educational Resources Information Center

    Alpi, Kristine M.

    2000-01-01

    Discusses the results of a survey, mainly from science and technology libraries, that asked about environmental policies and committees, individual and institutional attitudes and behavior related to recycling, and the effects of electronic journals and reserves on copying and printing. A copy of the electronic mail survey is appended. (Contains…

  3. 39 CFR 3007.10 - Submission of non-public materials under seal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-public materials shall submit two copies consisting, where practicable, of two paper hard copies as well... available PC application. Each page of any paper hard copy non-public materials submitted shall be clearly... submitted in a searchable electronic format, but need not be submitted in its native format. As part of its...

  4. 75 FR 44163 - Antidumping and Countervailing Duty Proceedings: Electronic Filing Procedures; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... Central Records Unit. Any questions concerning file formatting, document conversion, access on the Web, or... manually, a party need only submit one hard copy of the submission with the Department. The Department's regulations currently require parties to submit one hard copy original and five hard copies of a public...

  5. 37 CFR 1.19 - Document supply fees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... unless the original document is in color, a color copy is requested and the fee for a color copy is paid... portion of a patent application publication or patent, including a design patent, statutory invention....g., facsimile, electronic mail)—$3.00 (2) Printed copy of a plant patent in color: $15.00. (3) Color...

  6. Extremely Robust and Patternable Electrodes for Copy-Paper-Based Electronics.

    PubMed

    Ahn, Jaeho; Seo, Ji-Won; Lee, Tae-Ik; Kwon, Donguk; Park, Inkyu; Kim, Taek-Soo; Lee, Jung-Yong

    2016-07-27

    We propose a fabrication process for extremely robust and easily patternable silver nanowire (AgNW) electrodes on paper. Using an auxiliary donor layer and a simple laminating process, AgNWs can be easily transferred to copy paper as well as various other substrates using a dry process. Intercalating a polymeric binder between the AgNWs and the substrate through a simple printing technique enhances adhesion, not only guaranteeing high foldability of the electrodes, but also facilitating selective patterning of the AgNWs. Using the proposed process, extremely crease-tolerant electronics based on copy paper can be fabricated, such as a printed circuit board for a 7-segment display, portable heater, and capacitive touch sensor, demonstrating the applicability of the AgNWs-based electrodes to paper electronics.

  7. 48 CFR 1509.170-8 - Contractor Performance Report.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... electronically by use of the National Institutes of Health's Contractor Performance System. Hard copy preparation... Service Center with specific instructions if hard copy use becomes necessary. (b) The performance...

  8. 40 CFR 1517.7 - Records of closed meetings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provisions of § 1517.5. Copies of such transcript, minutes, or transcription of an electronic recording... or transcription. (e) [Reserved] (f) Requests to review or obtain copies of records other than...

  9. 75 FR 72832 - Neurological Devices Panel of the Medical Devices Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ..., rm. 1061, Rockville, MD 20852. Submit a single copy of electronic comments or a paper copy of any mailed comments, except that individuals may submit one paper copy. Comments are to be identified with... committee hot line/phone line to learn about possible modifications before coming to the meeting. Agenda: On...

  10. 77 FR 26448 - Revisions to the California State Implementation Plan, Antelope Valley Air Quality Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... electronically at www.regulations.gov and in hard copy at EPA Region IX, 75 Hawthorne Street, San Francisco... publicly available only at the hard copy location (e.g., copyrighted material, large maps), and some may not be publicly available in either location (e.g., CBI). To inspect the hard copy materials, please...

  11. 77 FR 40315 - Approval and Promulgation of Air Quality Implementation Plans; Colorado; Revisions to New Source...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    .... Certain other material, such as copyrighted material, will be publicly available only in hard copy. Publicly-available docket materials are available either electronically in www.regulations.gov or in hard... FURTHER INFORMATION CONTACT section to view the hard copy of the docket. You may view the hard copy of the...

  12. Multiple copies of genes coding for electron transport proteins in the bacterium Nitrosomonas europaea.

    PubMed

    McTavish, H; LaQuier, F; Arciero, D; Logan, M; Mundfrom, G; Fuchs, J A; Hooper, A B

    1993-04-01

    The genome of Nitrosomonas europaea contains at least three copies each of the genes coding for hydroxylamine oxidoreductase (HAO) and cytochrome c554. A copy of an HAO gene is always located within 2.7 kb of a copy of a cytochrome c554 gene. Cytochrome P-460, a protein that shares very unusual spectral features with HAO, was found to be encoded by a gene separate from the HAO genes.

  13. 49 CFR 174.24 - Shipping papers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... person receiving a shipping paper required by this section must retain a copy or an electronic image... reasonable times and locations. For a hazardous waste, each shipping paper copy must be retained for three...

  14. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... receiving a shipping paper required by this section must retain a copy or an electronic image thereof, that... reasonable times and locations. For a hazardous waste, each shipping paper copy must be retained for three...

  15. 49 CFR 174.24 - Shipping papers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... person receiving a shipping paper required by this section must retain a copy or an electronic image... reasonable times and locations. For a hazardous waste, each shipping paper copy must be retained for three...

  16. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... receiving a shipping paper required by this section must retain a copy or an electronic image thereof, that... reasonable times and locations. For a hazardous waste, each shipping paper copy must be retained for three...

  17. 49 CFR 174.24 - Shipping papers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... person receiving a shipping paper required by this section must retain a copy or an electronic image... reasonable times and locations. For a hazardous waste, each shipping paper copy must be retained for three...

  18. 49 CFR 176.24 - Shipping papers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... receiving a shipping paper required by this section must retain a copy or an electronic image thereof, that... reasonable times and locations. For a hazardous waste, each shipping paper copy must be retained for three...

  19. Servo scanning 3D micro EDM for array micro cavities using on-machine fabricated tool electrodes

    NASA Astrophysics Data System (ADS)

    Tong, Hao; Li, Yong; Zhang, Long

    2018-02-01

    Array micro cavities are useful in many fields including in micro molds, optical devices, biochips and so on. Array servo scanning micro electro discharge machining (EDM), using array micro electrodes with simple cross-sectional shape, has the advantage of machining complex 3D micro cavities in batches. In this paper, the machining errors caused by offline-fabricated array micro electrodes are analyzed in particular, and then a machining process of array servo scanning micro EDM is proposed by using on-machine fabricated array micro electrodes. The array micro electrodes are fabricated on-machine by combined procedures including wire electro discharge grinding, array reverse copying and electrode end trimming. Nine-array tool electrodes with Φ80 µm diameter and 600 µm length are obtained. Furthermore, the proposed process is verified by several machining experiments for achieving nine-array hexagonal micro cavities with top side length of 300 µm, bottom side length of 150 µm, and depth of 112 µm or 120 µm. In the experiments, a chip hump accumulates on the electrode tips like the built-up edge in mechanical machining under the conditions of brass workpieces, copper electrodes and the dielectric of deionized water. The accumulated hump can be avoided by replacing the water dielectric by an oil dielectric.

  20. Electronic Submissions of Pesticide Applications

    EPA Pesticide Factsheets

    Applications for pesticide registration can be submitted electronically, including forms, studies, and draft product labeling. Applicants need not submit multiple electronic copies of any pieces of their applications.

  1. 76 FR 47606 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... the following formats: One hard copy with original signature, and one electronic copy via e- mail (acceptable file formats are Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or rich text file...

  2. 77 FR 71820 - Meeting Announcement: North American Wetlands Conservation Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    .... Written statements must be supplied to the Council Coordinator in both of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe...

  3. 77 FR 34357 - Missile Defense Advisory Committee; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... Missile Defense Advisory Committee, in the following formats: One hard copy with original signature and one electronic copy via email (acceptable file formats: Adobe Acrobat PDF, MS Word or MS PowerPoint...

  4. 78 FR 33856 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... statements must be supplied to the Council Coordinator in one of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe Acrobat PDF, MS...

  5. 32 CFR 296.6 - Reading room.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Reading room. (a) The NRO shall provide a reading room equipped with hard copy and electronic records as... can be provided. (703) 808-5029. Fees will be charged for duplication of hard copy records at $.15 per...

  6. 32 CFR 296.6 - Reading room.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Reading room. (a) The NRO shall provide a reading room equipped with hard copy and electronic records as... can be provided. (703) 808-5029. Fees will be charged for duplication of hard copy records at $.15 per...

  7. 32 CFR 296.6 - Reading room.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Reading room. (a) The NRO shall provide a reading room equipped with hard copy and electronic records as... can be provided. (703) 808-5029. Fees will be charged for duplication of hard copy records at $.15 per...

  8. 32 CFR 296.6 - Reading room.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Reading room. (a) The NRO shall provide a reading room equipped with hard copy and electronic records as... can be provided. (703) 808-5029. Fees will be charged for duplication of hard copy records at $.15 per...

  9. 32 CFR 296.6 - Reading room.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Reading room. (a) The NRO shall provide a reading room equipped with hard copy and electronic records as... can be provided. (703) 808-5029. Fees will be charged for duplication of hard copy records at $.15 per...

  10. 76 FR 12280 - Revisions to the California State Implementation Plan, for Imperial County, Kern County, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... electronically at http://www.regulations.gov and in hard copy at EPA Region IX, 75 Hawthorne Street, San... publicly available only at the hard copy location (e.g., copyrighted material), and some may not be publicly available in either location (e.g., CBI). To inspect the hard copy materials, please schedule an...

  11. 36 CFR 1250.54 - General information on fees for NARA operational records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 11″) photocopy paper, we will copy them on larger paper and will reduce your copy fee by the normal... electronic files) we will provide the equivalent of 100 pages of standard size paper copies for free. (e) We... pay FOIA fees in the past, we will require you to pay your past-due bill before we begin processing...

  12. High-Performance electronics at ultra-low power consumption for space applications: From superconductor to nanoscale semiconductor technology

    NASA Technical Reports Server (NTRS)

    Duncan, Robert V.; Simmons, Jerry; Kupferman, Stuart; McWhorter, Paul; Dunlap, David; Kovanis, V.

    1995-01-01

    A detailed review of Sandia's work in ultralow power dissipation electronics for space flight applications, including superconductive electronics, new advances in quantum well structures, and ultra-high purity 3-5 materials, and recent advances in micro-electro-optical-mechanical systems (MEMS) is presented. The superconductive electronics and micromechanical devices are well suited for application in micro-robotics, micro-rocket engines, and advanced sensors.

  13. 77 FR 39252 - Meeting Announcement: North American Wetlands Conservation Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... statements must be supplied to the Council Coordinator in both of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe Acrobat PDF, MS...

  14. 76 FR 16736 - Closed Meeting of the Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Missile Defense Advisory Committee, in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file formats: Adobe Acrobat PDF, MS Word or MS PowerPoint...

  15. 78 FR 53156 - Sport Fishing and Boating Partnership Council; Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... Council Coordinator in one of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe Acrobat PDF, MS Word, MS PowerPoint, or rich...

  16. 77 FR 16891 - Commercial Space Transportation Advisory Committee-Open Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... the May 10 and 11, 2012 meetings. Written statements should be supplied in the following formats: one hard copy with original signature and/or one electronic copy via email. Subject to approval, a portion...

  17. 77 FR 59294 - Rules of Practice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... enforcement agencies of ``documentary material, results of inspections of tangible things, written reports or...: (1) Articulating staff's authority to inspect, copy, or sample documentary material--including..., copy, or sample documentary material, including electronic media. The proposal elicited extensive...

  18. Multi-Functional UV-Visible-IR Nanosensors Devices and Structures

    DTIC Science & Technology

    2015-04-29

    Dual-Gate MOSFET System, Proceedings of the International Workshop on Computational Electronics, Nara, Japan, Society of Micro- and Nanoelectronics ...International Workshop on Computational Electronics, Nara, Japan, Society of Micro- and Nanoelectronics , 216-217 (2013); ISBN 978-3-901578-26-7 M. S...Raman Spectroscopy, Proceedings of the International Workshop on Computational Electronics, Nara, Japan, Society of Micro- and Nanoelectronics , 198

  19. Are You Experienced The Case for Acquisition Professional Qualification Standards

    DTIC Science & Technology

    2015-10-01

    1, DAU 236), featuring a cover story on micro machines used in defense systems. The winners for Defense AT&L were managing edi - tor/senior editor of...Gonzalez, copy edi - tor and circulation manager; and Noelia Gamboa, editorial support. Defense AT&L’s sister DAU publication, the Defense Acquisition

  20. bt_50mwind

    Science.gov Websites

    for micro-siting potential development projects. This shapefile was generated from a raster dataset Sustainable Energy, LLC for the U.S. Department of Energy ("DOE"). The user is granted the right whatsoever, provided that this entire notice appears in all copies of the data. Further, the user of this

  1. 76 FR 45783 - Missile Defense Advisory Committee; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ..., in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file formats: Adobe Acrobat PDF, MS Word or MS PowerPoint), and this individual will ensure that...

  2. 76 FR 56143 - National Advisory Committee on Microbiological Criteria for Foods

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... hard copy format in the FSIS Docket Room. Often, an attempt is made to make the materials available at... formatting errors. The original document is the official, legal copy. In order to meet the electronic and...

  3. Blink Rate and Incomplete Blinks in Six Different Controlled Hard-Copy and Electronic Reading Conditions.

    PubMed

    Argilés, Marc; Cardona, Genís; Pérez-Cabré, Elisabet; Rodríguez, Margarita

    2015-10-01

    To evaluate spontaneous eye blink rate (SEBR) and percentage of incomplete blinks in different hard-copy and visual display terminal (VDT) reading conditions, compared with baseline conditions. A sample of 50 participants (29 females, age range, 18-74 years) were recruited for this study. All participants had good ocular health and reported no symptoms of dry eye (OSDI score < 15). Face video recordings were captured while participants observed in silence a landscape picture at 2 m (baseline) and during six different, 6-minute controlled reading experimental conditions. Texts were presented in electronic (tablet and computer display at 100% and 330% zoom levels) and hard-copy (text in book position in silence and aloud and text pasted on the computer display) formats. Video analysis was subsequently conducted to assess blink parameters. All reading conditions resulted in a decrease in SEBR when compared with baseline conditions (all P < 0.001), with the least negative impact corresponding to reading in a 330% expanded display. The percentage of incomplete blinks was found to increase when reading was conducted on an electronic platform, in contrast to hard-copy text. The high cognitive demands associated with a reading task led to a reduction in SEBR, irrespective of type of reading platform. However, only electronic reading resulted in an increase in the percentage of incomplete blinks, which may account for the symptoms experienced by VDT users. Spanish Abstract.

  4. Colloidal CdTe Nano Crystals Synthesis and Characterization

    DTIC Science & Technology

    2008-09-01

    Nibir Dhar, and Yuanping Chen Sensors and Electron Devices Directorate, ARL Gomatam Jaganathan and Sudhir Trivedi Brimrose Corporation...POLYTECHNIC INSTITUTE ATTN I BHAT TROY NJ 12180 10 BRIMROSE CORP OF AMERICA ATTN G JAGANATHAN (5 COPIES) ATTN S TRIVEDI (5 COPIES

  5. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... graphics, or audio or video material), notwithstanding the fact that its HTML or ASCII document counterpart... copy is not filed for purposes of section 11 of the Securities Act (15 U.S.C. 77k), section 18 of the...

  6. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... graphics, or audio or video material), notwithstanding the fact that its HTML or ASCII document counterpart... copy is not filed for purposes of section 11 of the Securities Act (15 U.S.C. 77k), section 18 of the...

  7. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... graphics, or audio or video material), notwithstanding the fact that its HTML or ASCII document counterpart... copy is not filed for purposes of section 11 of the Securities Act (15 U.S.C. 77k), section 18 of the...

  8. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... graphics, or audio or video material), notwithstanding the fact that its HTML or ASCII document counterpart... copy is not filed for purposes of section 11 of the Securities Act (15 U.S.C. 77k), section 18 of the...

  9. 17 CFR 232.104 - Unofficial PDF copies included in an electronic submission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... graphics, or audio or video material), notwithstanding the fact that its HTML or ASCII document counterpart... copy is not filed for purposes of section 11 of the Securities Act (15 U.S.C. 77k), section 18 of the...

  10. The B chromosomes in Brachycome.

    PubMed

    Leach, C R; Houben, A; Timmis, J N

    2004-01-01

    This review presents a historical account of studies of B chromosomes in the genus Brachycome Cass. (synonym: Brachyscome) from the earliest cytological investigations carried out in the late 1960s though to the most recent molecular analyses. Molecular analyses provide insights into the origin and evolution of the B chromosomes (Bs) of Brachycome dichromosomatica, a species which has Bs of two different sizes. The larger Bs are somatically stable whereas the smaller, or micro, Bs are somatically unstable. Both B types contain clusters of ribosomal RNA genes that have been shown unequivocally to be inactive in the case of the larger Bs. The large Bs carry a family of tandem repeat sequences (Bd49) that are located mainly at the centromere. Multiple copies of sequences related to this repeat are present on the A chromosomes (As) of related species, whereas only a few copies exist in the A chromosomes of B. dichromosomatica. The micro Bs share DNA sequences with the As and the larger Bs, and they also have B-specific repeats (Bdm29 and Bdm54). In some cases repeat sequences on the micro Bs have been shown to occur as clusters on the A chromosomes in a proportion of individuals within a population. It is clear that none of these B types originated by simple excision of segments from the A chromosomes. Copyright 2004 S. Karger AG, Basel

  11. cl_reg9_swcoast_50mwind

    Science.gov Websites

    is not suitable for micro-siting potential development projects. This shapefile was generated from a , LLC for the U.S. Department of Energy ("DOE"). The user is granted the right, without any , provided that this entire notice appears in all copies of the data. Further, the user of this data agrees

  12. mx_yuc_50mwind

    Science.gov Websites

    data is not suitable for micro-siting potential development projects. This shapefile was generated from ;). The user is granted the right, without any fee or cost, to use, copy, modify, alter, enhance and the data. Further, the user of this data agrees to credit NREL in any publications or software that

  13. Initial therapy with protease inhibitor-sparing regimens: evaluation of nevirapine and delavirdine.

    PubMed

    Conway, B

    2000-06-01

    We have compared the results (on-treatment analyses) of 2 randomized clinical trials of protease inhibitor-sparing regimens in drug-naive patients. In the INCAS (Italy, Netherlands, Canada, Australia) study, the mean decrease in plasma viral load over 52 weeks was 2.2 log(10) copies/mL in 40 patients who were receiving zidovudine/didanosine/nevirapine (18 [45%] had maximal suppression), with a mean increase in CD4 T cell counts of 139 cells/microL. In protocol 0021 Part II, the mean decrease in plasma viral load over 52 weeks was 2.1 log(10) copies/mL in 34 patients who were receiving zidovudine/lamivudine/delavirdine (20 [59%] had maximal suppression), with a mean increase in CD4 T cell counts of 88 cells/microL. The virologic and immunologic efficacy of the 2 triple-drug regimens are similar. Until results of long-term studies are available to establish whether a preferred approach to initial therapy exists, nonnucleoside reverse transcriptase inhibitors may be a valuable alternative to protease inhibitors in the initial therapy of antiretroviral-naive, moderately immunosuppressed patients.

  14. Micro-Bunched Beam Production at FAST for Narrow Band THz Generation Using a Slit-Mask

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hyun, J.; Crawford, D.; Edstrom Jr, D.

    We discuss simulations and experiments on creating micro-bunch beams for generating narrow band THz radiation at the Fermilab Accelerator Science and Technology (FAST) facility. The low-energy electron beamline at FAST consists of a photoinjector-based RF gun, two Lband superconducting accelerating cavities, a chicane, and a beam dump. The electron bunches are lengthened with cavity phases set off-crest for better longitudinal separation and then micro-bunched with a slit-mask installed in the chicane. We carried out the experiments with 30 MeV electron beams and detected signals of the micro-bunching using a skew quadrupole magnet in the chicane. In this paper, the detailsmore » of micro-bunch beam production, the detection of micro-bunching and comparison with simulations are described.« less

  15. 18 CFR 401.110 - Fees.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... include staff time associated with: (A) Processing FOIA requests; (B) Locating and reviewing files; (C) Monitoring file reviews; (D) Generating computer records (electronic print-outs); and (E) Preparing logs of..., black and white copies. The charge for copying standard sized, black and white public records shall be...

  16. 18 CFR 401.110 - Fees.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... include staff time associated with: (A) Processing FOIA requests; (B) Locating and reviewing files; (C) Monitoring file reviews; (D) Generating computer records (electronic print-outs); and (E) Preparing logs of..., black and white copies. The charge for copying standard sized, black and white public records shall be...

  17. 20 CFR 401.95 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS AND INFORMATION The Privacy Act § 401.95 Fees. (a) Policy. Where applicable, we will charge fees for copying records in... system of records, whether the search is manual, mechanical, or electronic. Where we must copy the record...

  18. 12 CFR 551.110 - May I provide a notice electronically?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... use other electronic communications if: (a) The parties agree to use electronic instead of hard copy notices; (b) The parties are able to print or download the notice; (c) Your electronic communications system cannot automatically delete the electronic notice; and (d) Both parties are able to receive...

  19. 20 CFR 655.34 - Electronic job registry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Electronic job registry. 655.34 Section 655... Electronic job registry. (a) Location of and placement in the electronic job registry. Upon acceptance of the... copy of the job order posted by the SWA on the Department's electronic job registry, including any...

  20. 20 CFR 655.34 - Electronic job registry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Electronic job registry. 655.34 Section 655... Electronic job registry. (a) Location of and placement in the electronic job registry. Upon acceptance of the... copy of the job order posted by the SWA on the Department's electronic job registry, including any...

  1. Structure of catalase determined by MicroED

    PubMed Central

    Nannenga, Brent L; Shi, Dan; Hattne, Johan; Reyes, Francis E; Gonen, Tamir

    2014-01-01

    MicroED is a recently developed method that uses electron diffraction for structure determination from very small three-dimensional crystals of biological material. Previously we used a series of still diffraction patterns to determine the structure of lysozyme at 2.9 Å resolution with MicroED (Shi et al., 2013). Here we present the structure of bovine liver catalase determined from a single crystal at 3.2 Å resolution by MicroED. The data were collected by continuous rotation of the sample under constant exposure and were processed and refined using standard programs for X-ray crystallography. The ability of MicroED to determine the structure of bovine liver catalase, a protein that has long resisted atomic analysis by traditional electron crystallography, demonstrates the potential of this method for structure determination. DOI: http://dx.doi.org/10.7554/eLife.03600.001 PMID:25303172

  2. 12 CFR 344.4 - Recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... format a bank deems appropriate, provided however, the records required by this section must clearly and.... Records may be maintained in hard copy, automated or electronic form provided the records are easily retrievable, readily available for inspection, and capable of being reproduced in a hard copy. A bank may...

  3. INSTRUMENTATION AND CONTROLS DIVISION ELECTRICAL DESIGN STANDARDS AND GRAPHICAL SYMBOLS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1961-11-01

    Copies are presented of the American Standards Association graphical symbols for electrical and electronic equipment and systems. Recommendations are given for electrical elementary design layout, device codings, etc., for permanent type installations. Electrical diagrams copied from American Drafting Standards Manual are presented. (M.C.G.)

  4. Optimisation of tomato Micro-tom regeneration and selection on glufosinate/Basta and dependency of gene silencing on transgene copy number.

    PubMed

    Khuong, Thi Thu Huong; Crété, Patrice; Robaglia, Christophe; Caffarri, Stefano

    2013-09-01

    An efficient protocol of transformation and selection of transgenic lines of Micro-tom, a widespread model cultivar for tomato, is reported. RNA interference silencing efficiency and stability have been investigated and correlated with the number of insertions. Given its small size and ease of cultivation, the tomato (Solanum lycopersicon) cultivar Micro-tom is of widespread use as a model tomato plant. To create and screen transgenic plants, different selectable markers are commonly used. The bar marker carrying the resistance to the herbicide glufosinate/Basta, has many advantages, but it has been little utilised and with low efficiency for identification of tomato transgenic plants. Here we describe a procedure for accurate selection of transgenic Micro-tom both in vitro and in soil. Immunoblot, Southern blot and phenotypic analyses showed that 100 % of herbicide-resistant plants were transgenic. In addition, regeneration improvement has been obtained by using 2 mg/l Gibberellic acid in the shoot elongation medium; rooting optimisation on medium containing 1 mg/l IAA allowed up to 97 % of shoots developing strong and very healthy roots after only 10 days. Stable transformation frequency by infection of leaf explants with Agrobacterium reached 12 %. Shoots have been induced by combination of 1 mg/l zeatin-trans and 0.1 mg/l IAA. Somatic embryogenesis of cotyledon on medium containing 1 mg/l zeatin + 2 mg/l IAA is described in Micro-tom. The photosynthetic psbS gene has been used as reporter gene for RNA silencing studies. The efficiency of gene silencing has been found equivalent using three different target gene fragments of 519, 398 and 328 bp. Interestingly, silencing efficiency decreased from T0 to the T3 generation in plants containing multiple copies of the inserted T-DNA, while it was stable in plants containing a single insertion.

  5. 20 CFR 655.144 - Electronic job registry.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Electronic job registry. 655.144 Section 655... Certification § 655.144 Electronic job registry. (a) Location of and placement in the electronic job registry... promptly place for public examination a copy of the job order on an electronic job registry maintained by...

  6. 20 CFR 655.144 - Electronic job registry.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Electronic job registry. 655.144 Section 655... Certification § 655.144 Electronic job registry. (a) Location of and placement in the electronic job registry... promptly place for public examination a copy of the job order on an electronic job registry maintained by...

  7. 20 CFR 655.144 - Electronic job registry.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Electronic job registry. 655.144 Section 655... Certification § 655.144 Electronic job registry. (a) Location of and placement in the electronic job registry... promptly place for public examination a copy of the job order on an electronic job registry maintained by...

  8. 20 CFR 655.144 - Electronic job registry.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Electronic job registry. 655.144 Section 655... Certification § 655.144 Electronic job registry. (a) Location of and placement in the electronic job registry... promptly place for public examination a copy of the job order on an electronic job registry maintained by...

  9. 20 CFR 655.144 - Electronic job registry.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Electronic job registry. 655.144 Section 655... Certification § 655.144 Electronic job registry. (a) Location of and placement in the electronic job registry... promptly place for public examination a copy of the job order on an electronic job registry maintained by...

  10. 49 CFR 177.817 - Shipping papers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... Except for a hazardous waste, the certification is not required for shipments to be transported entirely... shipping paper required by this section must retain a copy or an electronic image thereof, that is... locations. For a hazardous waste, the shipping paper copy must be retained for three years after the...

  11. 76 FR 38977 - Approval and Promulgation of Air Quality Implementation Plans, State of Louisiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... submitted by the State of Louisiana, and include formatting changes, regulatory wording changes, substantive... other material, such as copyrighted material will be publicly available only in hard copy. Publicly available docket materials are available either electronically in http://www.regulations.gov or in hard copy...

  12. 32 CFR 22.420 - Pre-award procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Pre-award procedures. 22.420 Section 22.420 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT...)). 5 Electronic copies may be obtained at Internet site http://www.whitehouse.gov/OMB. For paper copies...

  13. 32 CFR 22.420 - Pre-award procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Pre-award procedures. 22.420 Section 22.420 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT...)). 5 Electronic copies may be obtained at Internet site http://www.whitehouse.gov/OMB. For paper copies...

  14. 17 CFR 1.31 - Books and records; keeping and inspection.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., easily readable projection or production of micrographic media or electronic storage media images; (ii... keep such records, any easily readable hard-copy image that representatives of the Commission or... such records, copies of such records on such compatible data processing media as defined in § 15.00(d...

  15. 17 CFR 1.31 - Books and records; keeping and inspection.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., easily readable projection or production of micrographic media or electronic storage media images; (ii... keep such records, any easily readable hard-copy image that representatives of the Commission or... such records, copies of such records on such compatible data processing media as defined in § 15.00(d...

  16. 77 FR 70776 - Draft Integrated Science Assessment for Lead

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... certain pollutants which, among other things, ``cause or contribute to air pollution, which may reasonably... available only in hard copy. Publicly available docket materials are available either electronically in www.regulations.gov or in hard copy at the OEI Docket in the EPA Headquarters Docket Center. Dated: September 28...

  17. 18 CFR 33.8 - Number of copies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATIONS UNDER FEDERAL POWER ACT SECTION 203 § 33.8 Number of copies. The applicant must submit the application or petition to the Secretary of the..., the applicant must submit all such information in electronic format (e.g., on computer diskette or on...

  18. 18 CFR 33.8 - Number of copies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATIONS UNDER FEDERAL POWER ACT SECTION 203 § 33.8 Number of copies. The applicant must submit the application or petition to the Secretary of the..., the applicant must submit all such information in electronic format (e.g., on computer diskette or on...

  19. 49 CFR 194.119 - Submission and approval procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.119 Submission and approval procedures. (a) Each operator shall submit two copies of the response plan required by this part. Copies of the response plan...: Submission of plans in electronic format is preferred. (b) If PHMSA determines that a response plan requiring...

  20. 49 CFR 194.119 - Submission and approval procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.119 Submission and approval procedures. (a) Each operator shall submit two copies of the response plan required by this part. Copies of the response plan...: Submission of plans in electronic format is preferred. (b) If PHMSA determines that a response plan requiring...

  1. 49 CFR 194.119 - Submission and approval procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.119 Submission and approval procedures. (a) Each operator shall submit two copies of the response plan required by this part. Copies of the response plan...: Submission of plans in electronic format is preferred. (b) If PHMSA determines that a response plan requiring...

  2. 49 CFR 194.119 - Submission and approval procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.119 Submission and approval procedures. (a) Each operator shall submit two copies of the response plan required by this part. Copies of the response plan...: Submission of plans in electronic format is preferred. (b) If PHMSA determines that a response plan requiring...

  3. 49 CFR 194.119 - Submission and approval procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PLANS FOR ONSHORE OIL PIPELINES Response Plans § 194.119 Submission and approval procedures. (a) Each operator shall submit two copies of the response plan required by this part. Copies of the response plan...: Submission of plans in electronic format is preferred. (b) If PHMSA determines that a response plan requiring...

  4. 45 CFR 5b.13 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.13 Fees. (a) Policy. Where applicable, fees for copying records will be charged in accordance with the schedule set... whether the search is manual, mechanical, or electronic. Where a copy of the record must be made in order...

  5. BEAMing LAMP: single-molecule capture and on-bead isothermal amplification for digital detection of hepatitis C virus in plasma.

    PubMed

    Chen, Jiyun; Xu, Xiaomin; Huang, Zhimei; Luo, Yuan; Tang, Lijuan; Jiang, Jian-Hui

    2018-01-02

    A novel dNAD platform (BEAMing LAMP) by combining emulsion micro-reactors, single-molecule magnetic capture and on-bead loop-mediated isothermal amplification has been developed for DNA detection, which enables absolute and high-precision quantification of a target with a detection limit of 300 copies.

  6. Calibrating the MicroBooNE Photomultiplier Tube (PMT) Array with Michel Electrons from Cosmic Ray Muons

    NASA Astrophysics Data System (ADS)

    Greene, Amy

    2013-04-01

    MicroBooNE is a neutrino experiment at Fermilab designed to investigate the 3σ low-energy electron candidate events measured by the MiniBooNE experiment. Neutrinos from the Booster Neutrino Beam are detected by a 89-ton liquid argon time projection chamber, which is expected to start taking data in 2014. MicroBooNE measures both the ionization electrons and scintillation light produced by neutrino interactions in the liquid argon. The scintillation light is collected by an array of 30 PMTs located at one side of the detector. This array can be calibrated using Michel electrons from stopping cosmic ray muons, by fitting the measured PMT response with the theoretical expectation. I will report on the progress of the PMT calibration software that has been developed using the MicroBooNE Monte Carlo.

  7. Reconstructing Michel Electrons in the MicroBooNE Detector

    NASA Astrophysics Data System (ADS)

    Caratelli, David

    2016-03-01

    MicroBooNE is a Liquid Argon Time Projection Chamber (LArTPC) neutrino detector located in the Booster Neutrino Beamline at Fermilab which began collecting neutrino data in October 2015. MicroBooNE aims to explore the low-energy excess in the νe spectrum reported by MiniBooNE as well as perform ν-Ar cross-section measurements. In this talk, we present the current status of reconstructing Michel electrons from cosmic ray muons in the MicroBooNE detector. These Michel electrons are distributed uniformly inside the detector, and serve as a natural and powerful calibration source to study the detector's response for low energy (10s of MeV) interactions as a function of position. We have developed a reconstruction software tool to successfully identify such Michel electrons which could be of benefit to LArTPC experiments generically.

  8. Agrobacterium rhizogenes-mediated DNA transfer to Aesculus hippocastanum L. and the regeneration of transformed plants.

    PubMed

    Zdravković-Korać, S; Muhovski, Y; Druart, P; Calić, D; Radojević, L

    2004-04-01

    Hairy roots were induced from androgenic embryos of horse chestnut (Aesculus hippocastanum L.) by infection with Agrobacterium rhizogenes strain A4GUS. Single roots were selected according to their morphology in the absence of antibiotic or herbicide resistance markers. Seventy-one putative transformed hairy root lines from independent transformation events were established. Regeneration was induced in MS liquid medium supplemented with 30 microM 6-benzylaminopurine (BA), and the regenerants were multiplied on MS solid medium containing 10 microM BA. Following elongation on MS medium supplemented with 1 microM BA and 500 mg/l polyvinylpyrrolidone, the shoots were subjected to a root-inducing treatment. Stable integration of TL-DNA within the horse chestnut genome was confirmed by Southern hybridization. The copy number of transgenes was estimated to be from two to four.

  9. 78 FR 72608 - Approval and Promulgation of Implementation Plans; State of Missouri

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ..., such as copyrighted material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in www.regulations.gov or in hard copy at the Environmental... consistent with the state's standard rule format or make other minor clarifying changes. Subparagraphs 3(B)3...

  10. 76 FR 75898 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... following formats: One hard copy with original signature, and one electronic copy via email (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Please submit your statement to Douglas Hobbs, Council Coordinator (see FOR FURTHER...

  11. 76 FR 10544 - Approval and Promulgation of Air Quality Implementation Plans, State of Louisiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ..., were submitted by the State of Louisiana, and include formatting changes, regulatory wording changes... available only in hard copy. Publicly available docket materials are available either electronically in http://www.regulations.gov or in hard copy at the Air Planning Section (6PD- L), Environmental Protection...

  12. 76 FR 64240 - Approval and Promulgation of Implementation Plans; North Carolina: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... and will be publicly available only in hard copy form. Publicly available docket materials are available either electronically through http://www.regulations.gov or in hard copy at the Regulatory... revision on May 17, 2011. In its final SIP revision, North Carolina made minor [[Page 64241

  13. 77 FR 71145 - Approval and Promulgation of Implementation Plans; New Mexico; New Source Review (NSR...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-29

    ... material, such as copyrighted material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in http://www.regulations.gov or in hard copy at the... renumbering of several existing sections and formatting changes that were made throughout the entire Part...

  14. 14 CFR 221.121 - How to prepare and file applications for Special Tariff Permission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Special Tariff Permission To... notice shall conform to the requirements of § 221.212 if filed electronically. (b) Number of paper copies and place of filing. For paper format applications, the original and one copy of each such application...

  15. 30 CFR 285.417 - When may MMS order a suspension?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER... of national security or defense. (b) If MMS orders a suspension under paragraph (a)(2) of this... paper copy and one electronic copy of the study and results to us; (3) We will make the results...

  16. 30 CFR 585.417 - When may BOEM order a suspension?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 585.417 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... archaeological significance; or (3) When the suspension is necessary for reasons of National security or defense... may be required to pay for the study; (2) You must furnish one paper copy and one electronic copy of...

  17. 30 CFR 585.417 - When may BOEM order a suspension?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 585.417 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... archaeological significance; or (3) When the suspension is necessary for reasons of National security or defense... may be required to pay for the study; (2) You must furnish one paper copy and one electronic copy of...

  18. 30 CFR 585.417 - When may BOEM order a suspension?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 585.417 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE... archaeological significance; or (3) When the suspension is necessary for reasons of National security or defense... may be required to pay for the study; (2) You must furnish one paper copy and one electronic copy of...

  19. 76 FR 11963 - Updating Cross-References for the Oklahoma State Implementation Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... material, such as copyrighted material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in http://www.regulations.gov or in hard copy at the... (CAA), among other things, further provides that CAA subsection 307(d) does not apply when EPA has made...

  20. 77 FR 41343 - Approval and Promulgation of Implementation Plans; North Dakota: Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in www.regulations.gov or in hard copy at the Air Program, Environmental Protection... possible, you contact the individual listed in the FOR FURTHER INFORMATION CONTACT section to view the hard...

  1. 8 CFR 214.3 - Approval of schools for enrollment of F and M nonimmigrants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... students and trainees, and finances (including a certified copy of the accountant's last statement of... of a denial or withdrawal. The term “in writing” means either a paper copy bearing original... in the certification as part of the site visit. Paper or electronic access is acceptable. DSOs must...

  2. 75 FR 63120 - Release of Information From Department of Veterans Affairs Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... information concerning the procedures for obtaining a copy of VA's Annual Report. 1.553 Public Reading Rooms... public for inspection and copying; and (3) that public reading facilities will be maintained by VA... that VA maintains a public reading room electronically at its FOIA home page on the Internet, which...

  3. 78 FR 325 - Consideration of Approval of Application Regarding Proposed Creation of a Holding Company and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-03

    ... determination by the presiding officer that the filing demonstrates good cause by satisfying the following three... cases to mail copies on electronic storage media. Participants may not submit paper copies of their... through Friday, excluding government holidays. Participants who believe that they have a good cause for...

  4. 77 FR 1743 - Facility Operating License Amendment From Florida Power Corporation, Crystal River Nuclear...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... cases to mail copies on electronic storage media. Participants may not submit paper copies of their... Friday, excluding government holidays. Participants who believe that they have a good cause for not... privacy information, such as social security numbers, home addresses, or home phone numbers in their...

  5. 78 FR 31978 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... cases to mail copies on electronic storage media. Participants may not submit paper copies of their... Friday, excluding government holidays. Participants who believe that they have a good cause for not... privacy information, such as social security numbers, home addresses, or home phone numbers in their...

  6. Megavolt, Multi-Kiloamp Ka-Band Gyrotron Oscillator Experiment

    DTIC Science & Technology

    1989-03-15

    pulseline accelerator with 20 K2 output impedance and 55 nsec voltage pulse was used to generate a multi-kiloamp annular electron beam by explosive plasma...Lawrence Livermore National Laboratory P.O. Box 808 Livermore, California 94550 Attn: Dr. D. Prosnitz 1 copy Dr. T.J. Orzechowski 1 copy Dr. J. Chase 1

  7. INVESTIGATION OF TITANIUM BONDED GRAPHITE FOAM COMPOSITES FOR MICRO ELECTRONIC MECHANICAL SYSTEMS (MEMS) APPLICATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Menchhofer, Paul A.

    PiMEMS Inc. (Santa Barbara, CA) in collaboration with ORNL investigated the use of Titanium Bonded Graphite Foam Composites (TBGC) for thermal mitigation in Micro Electronic Mechanical Systems (MEMS) applications. Also considered were potentially new additive manufacturing routes to producing novel high surface area micro features and diverse shaped heat transfer components for numerous lightweight MEMs applications.

  8. 3M's Dry Silver technology: an ideal media for electronic imaging

    NASA Astrophysics Data System (ADS)

    Morgan, David A.

    1991-08-01

    In recent years there has been great interest and growth in the ability to create images electronically. This trend has been driven by the lower cost of computing and storing data, and the speed in which this can be accomplished. The ability to scan, create, and transmit color images is possible even with the enormous amount of data needed to create color images with gray scale and high resolution. In the past, there has not been a great demand for color copiers because few color images were in existence. The above-mentioned trend is changing this, and in addition scanners can quickly translate color graphics into electronic forms at affordable costs. The replacement of black and white televisions and monitors with color was rapid and nearly 100% once the technology was available at a reasonable cost. It is felt by some equipment manufacturers that soft copy will replace hard copy and there will be a diminishing need for imaging media. The author believes, however, that the need for hard copy will continue, and in fact may increase, but with new technology. To create black and white or color hard copy from electronically generated data, some essential characteristics are needed. They are: (1) total dryness, (2) rapid access, (3) gray scale, (4) high resolution, (5) good image quality, and (6) easy to use, low-cost, reliable equipment. Some of the leading technologies for this are electrostatic, thermal dye transfer, ink jet, instant silver photography, and 3M's Dry Silver. This paper gives a general overview of these technologies, but its main emphasis is 3M's Dry Silver approach.

  9. 36 CFR § 1235.44 - What general transfer requirements apply to electronic records?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements apply to electronic records? § 1235.44 Section § 1235.44 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT TRANSFER OF RECORDS TO THE NATIONAL... requirements apply to electronic records? (a) Each agency must retain a copy of permanent electronic records...

  10. 12 CFR 551.110 - May I provide a notice electronically?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false May I provide a notice electronically? 551.110 Section 551.110 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY RECORDKEEPING... use other electronic communications if: (a) The parties agree to use electronic instead of hard copy...

  11. 37 CFR 202.24 - Deposit of published electronic works available only online.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... electronic works available only online. 202.24 Section 202.24 Patents, Trademarks, and Copyrights U.S... CLAIMS TO COPYRIGHT § 202.24 Deposit of published electronic works available only online. (a) Pursuant to... copy or a phonorecord of an electronic work published in the United States and available only online...

  12. 78 FR 64294 - Loan Guaranty: Mandatory Electronic Delivery of Loan Files for Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... DEPARTMENT OF VETERANS AFFAIRS Loan Guaranty: Mandatory Electronic Delivery of Loan Files for... through either electronic upload or in hard copy form. Effective January 1, 2014, LGY will require the electronic uploading of all loan files, pursuant to 38 CFR 36.4333. DATES: Effective January 1, 2014, VA will...

  13. Direct acceleration of electrons by a CO2 laser in a curved plasma waveguide

    PubMed Central

    Yi, Longqing; Pukhov, Alexander; Shen, Baifei

    2016-01-01

    Laser plasma interaction with micro-engineered targets at relativistic intensities has been greatly promoted by recent progress in the high contrast lasers and the manufacture of advanced micro- and nano-structures. This opens new possibilities for the physics of laser-matter interaction. Here we propose a novel approach that leverages the advantages of high-pressure CO2 laser, laser-waveguide interaction, as well as micro-engineered plasma structure to accelerate electrons to peak energy greater than 1 GeV with narrow slice energy spread (~1%) and high overall efficiency. The acceleration gradient is 26 GV/m for a 1.3 TW CO2 laser system. The micro-bunching of a long electron beam leads to the generation of a chain of ultrashort electron bunches with the duration roughly equal to half-laser-cycle. These results open a way for developing a compact and economic electron source for diverse applications. PMID:27320197

  14. Trains of electron micro-bunches in plasma wake-field acceleration

    NASA Astrophysics Data System (ADS)

    Lécz, Zsolt; Andreev, Alexander; Konoplev, Ivan; Seryi, Andrei; Smith, Jonathan

    2018-07-01

    Plasma-based charged particle accelerators have been intensively investigated in the past three decades due to their capability to open up new horizons in accelerator science and particle physics yielding electric field accelerating gradient more than three orders of magnitudes higher than in conventional devices. At the current stage the most advanced and reliable mechanism for accelerating electrons is based on the propagation of an intense laser pulse or a relativistic electron beam in a low density gaseous target. In this paper we concentrate on the electron beam-driven plasma wake-field acceleration and demonstrate using 3D PiC simulations that a train of electron micro-bunches with ∼10 fs period can be generated behind the driving beam propagating in a density down-ramp. We will discuss the conditions and properties of the micro-bunches generated aiming at understanding and study of multi-bunch mechanism of injection. It is show that the periodicity and duration of micro-bunches can be controlled by adjusting the plasma density gradient and driving beam charge.

  15. 10 CFR 431.15 - Materials incorporated by reference.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....03, IBR approved for § 431.12. (2) Institute of Electrical and Electronics Engineers, Inc., Standard...) Copies of IEEE Standard 112-1996 can be obtained from the Institute of Electrical and Electronics...

  16. 40 CFR 60.676 - Reporting and recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...), including dates and any corrective actions taken, in a logbook (in written or electronic format). The owner or operator must keep the logbook onsite and make hard or electronic copies (whichever is requested...

  17. The collection of MicroED data for macromolecular crystallography.

    PubMed

    Shi, Dan; Nannenga, Brent L; de la Cruz, M Jason; Liu, Jinyang; Sawtelle, Steven; Calero, Guillermo; Reyes, Francis E; Hattne, Johan; Gonen, Tamir

    2016-05-01

    The formation of large, well-ordered crystals for crystallographic experiments remains a crucial bottleneck to the structural understanding of many important biological systems. To help alleviate this problem in crystallography, we have developed the MicroED method for the collection of electron diffraction data from 3D microcrystals and nanocrystals of radiation-sensitive biological material. In this approach, liquid solutions containing protein microcrystals are deposited on carbon-coated electron microscopy grids and are vitrified by plunging them into liquid ethane. MicroED data are collected for each selected crystal using cryo-electron microscopy, in which the crystal is diffracted using very few electrons as the stage is continuously rotated. This protocol gives advice on how to identify microcrystals by light microscopy or by negative-stain electron microscopy in samples obtained from standard protein crystallization experiments. The protocol also includes information about custom-designed equipment for controlling crystal rotation and software for recording experimental parameters in diffraction image metadata. Identifying microcrystals, preparing samples and setting up the microscope for diffraction data collection take approximately half an hour for each step. Screening microcrystals for quality diffraction takes roughly an hour, and the collection of a single data set is ∼10 min in duration. Complete data sets and resulting high-resolution structures can be obtained from a single crystal or by merging data from multiple crystals.

  18. Associations of common copy number variants in glutathione S-transferase mu 1 and D-dopachrome tautomerase-like protein genes with risk of schizophrenia in a Japanese population.

    PubMed

    Nakamura, Toru; Ohnuma, Tohru; Hanzawa, Ryo; Takebayashi, Yuto; Takeda, Mayu; Nishimon, Shohei; Sannohe, Takahiro; Katsuta, Narimasa; Higashiyama, Ryoko; Shibata, Nobuto; Arai, Heii

    2015-10-01

    Oxidative-stress, genetic regions of interest (1p13 and 22q11), and common copy number variations (CNVs) may play roles in the pathophysiology of schizophrenia. In the present study, we confirmed associations between schizophrenia and the common CNVs in the glutathione (GSH)-related genes GSTT1, DDTL, and GSTM1 using quantitative real-time polymerase chain reaction analyses of 620 patients with schizophrenia and in 622 controls. No significant differences in GSTT1 copy number distributions were found between patient groups. However, frequencies of characterized CNVs and assumed gain alleles of DDTL and GSTM1 were significantly higher in patients with schizophrenia. In agreement with a previous report, the present data indicate that gains in the CNV alleles DDTL and GSTM1 are genetic risk factors in Japanese patients with schizophrenia, and suggest involvement of micro-inflammation and oxidative stress in the pathophysiology of schizophrenia. © 2015 Wiley Periodicals, Inc.

  19. A large-scale survey of genetic copy number variations among Han Chinese residing in Taiwan

    PubMed Central

    Lin, Chien-Hsing; Li, Ling-Hui; Ho, Sheng-Feng; Chuang, Tzu-Po; Wu, Jer-Yuarn; Chen, Yuan-Tsong; Fann, Cathy SJ

    2008-01-01

    Background Copy number variations (CNVs) have recently been recognized as important structural variations in the human genome. CNVs can affect gene expression and thus may contribute to phenotypic differences. The copy number inferring tool (CNIT) is an effective hidden Markov model-based algorithm for estimating allele-specific copy number and predicting chromosomal alterations from single nucleotide polymorphism microarrays. The CNIT algorithm, which was constructed using data from 270 HapMap multi-ethnic individuals, was applied to identify CNVs from 300 unrelated Han Chinese individuals in Taiwan. Results Using stringent selection criteria, 230 regions with variable copy numbers were identified in the Han Chinese population; 133 (57.83%) had been reported previously, 64 displayed greater than 1% CNV allele frequency. The average size of the CNV regions was 322 kb (ranging from 1.48 kb to 5.68 Mb) and covered a total of 2.47% of the human genome. A total of 196 of the CNV regions were simple deletions and 27 were simple amplifications. There were 449 genes and 5 microRNAs within these CNV regions; some of these genes are known to be associated with diseases. Conclusion The identified CNVs are characteristic of the Han Chinese population and should be considered when genetic studies are conducted. The CNV distribution in the human genome is still poorly characterized, and there is much diversity among different ethnic populations. PMID:19108714

  20. Electron Attenuation Measurement using Cosmic Ray Muons at the MicroBooNE LArTPC

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meddage, Varuna

    2017-10-01

    The MicroBooNE experiment at Fermilab uses liquid argon time projection chamber (LArTPC) technology to study neutrino interactions in argon. A fundamental requirement for LArTPCs is to achieve and maintain a low level of electronegative contaminants in the liquid to minimize the capture of drifting ionization electrons. The attenuation time for the drifting electrons should be long compared to the maximum drift time, so that the signals from particle tracks that generate ionization electrons with long drift paths can be detected efficiently. In this talk we present MicroBooNE measurement of electron attenuation using cosmic ray muons. The result yields a minimummore » electron 1/e lifetime of 18 ms under typical operating conditions, which is long compared to the maximum drift time of 2.3 ms.« less

  1. The Art of Electronics - 2nd Edition

    NASA Astrophysics Data System (ADS)

    Horowitz, Paul; Hill, Winfield

    1989-09-01

    This is the thoroughly revised and updated second edition of the hugely successful The Art of Electronics. Widely accepted as the single authoritative text and reference on electronic circuit design, both analog and digital, the original edition sold over 125,000 copies worldwide and was translated into eight languages. The book revolutionized the teaching of electronics by emphasizing the methods actually used by citcuit designers - a combination of some basic laws, rules to thumb, and a large nonmathematical treatment that encourages circuit values and performance. The new Art of Electronics retains the feeling of informality and easy access that helped make the first edition so successful and popular. It is an ideal first textbook on electronics for scientists and engineers and an indispensable reference for anyone, professional or amateur, who works with electronic circuits. The best self-teaching book and reference book in electronics Simply indispensable, packed with essential information for all scientists and engineers who build electronic circuits Totally rewritten chapters on microcomputers and microprocessors The first edition of this book has sold over 100,000 copies in seven years, it has a market in virtually all research centres where electronics is important

  2. 32 CFR 518.7 - FOIA terms defined.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... books, papers, maps, photographs, and machine readable materials, inclusive of those in electronic form... create or compile a record to satisfy a FOIA request. (3) Hard copy or electronic records that are... conduct. (h) Electronic record. Records (including e-mail) that are created, stored, and retrievable by...

  3. 32 CFR 701.18 - Agency record.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., photographs, machine readable materials, inclusive of those in electronic form or format, or other documentary...) Hard copy or electronic records, which are subject to FOIA requests under 5 U.S.C. 552(a)(3), and which...

  4. 32 CFR 299.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... electronic form or format (including e-mails), or other documentary materials, regardless of physical form or... not object. (3) Hard copy or electronic records that are subject to FOIA requests under 5 U.S.C. 552(a...

  5. 75 FR 47624 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Coordinator in both of the following formats: One hard copy with original signature, and one electronic copy via e- mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). In order to attend this meeting, you must register by...

  6. 49 CFR 225.37 - Magnetic media transfer and electronic submission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Form (Form FRA F 6180.99); and (3) A notarized hard copy of the Railroad Injury and Illness Summary....99) which is submitted to an FRA-designated computer; and (2) A notarized hard copy of the Railroad... reporting data for the reports identified in paragraph (a) of this section in a year-to-date file format as...

  7. 77 FR 10387 - Designation of Hazardous Substances; Designation, Reportable Quantities, and Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in www.regulations.gov or in hard copy at the EPA-HQ-SFUND-2011-0965 docket. This.... 302.6 was the result of a formatting error. On November 8, 2000, EPA issued a final rule (65 FR 67132...

  8. 78 FR 52473 - Approval and Promulgation of Implementation Plans; New Mexico; Prevention of Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... copyrighted material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in http://www.regulations.gov or in hard copy at the Air Permits Section..., Non-substantive revisions to 20.2.74.7(AZ)(1), (2), (2)(b), (3), (4), and (5) to correct formatting...

  9. Online Texts and Conventional Texts: Estimating, Comparing, and Reducing the Greenhouse Gas Footprint of Two Tools of the Trade

    ERIC Educational Resources Information Center

    Gattiker, Thomas F.; Lowe, Scott E.; Terpend, Regis

    2012-01-01

    Many universities are endeavoring to understand and reduce their greenhouse gas (GHG) emissions--or carbon footprints. Hard-copy textbooks are (perhaps surprisingly) a large component of this footprint. Because they are "virtual," electronic texts (e-texts) are often considered environmentally superior to conventional hard-copy texts.…

  10. 78 FR 41428 - In the Matter of Licensee Identified in Attachment 1 and All Other Persons Who Obtain Safeguards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... mail copies on electronic storage media. Participants may not submit paper copies of their filings...-415-1677, to request (1) a digital identification (ID) certificate, which allows the participant (or... representative, already holds an NRC- issued digital ID certificate). Based upon this information, the Secretary...

  11. 78 FR 2210 - Review of New Sources and Modifications in Indian Country: Notice of Action Partially Granting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ..., the Petitioners). In the letter dated August 30, 2011, the Petitioners asked, among other things, that... and will be publicly available only in hard copy form. Publicly available docket materials are available electronically through http://www.regulations.gov or in hard copy at the EPA Docket Center, Docket...

  12. 77 FR 40384 - Proposed Information Collection Activity: Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... victims' family members and friends. The NTSB will transmit either a paper copy or an electronic copy of the form to victims' family members and friends. This Notice informs the public that they may submit..., of victims of transportation accidents, and/or victims' family members and friends. 77 FR 18269 (Mar...

  13. 77 FR 65019 - DBI, Inc., Casper, WY; Confirmatory Order Modifying License (Effective Immediately)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... Investigations (OI), Region IV, began an investigation (OI Case No. 4-2011-060) to determine if the Licensee... participants to submit and serve all adjudicatory documents over the internet, or in some cases to mail copies on electronic storage media. Participants may not submit paper copies of their filings unless they...

  14. 78 FR 3470 - Aptuit, LLC; License Amendment Request, Opportunity To Provide Comments, Request a Hearing and To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... cases to mail copies on electronic storage media. Participants may not submit paper copies of their... Friday, excluding government holidays. Participants who believe that they have a good cause for not... information, such as Social Security numbers, home addresses, or home phone numbers in their filings, unless...

  15. 76 FR 7590 - Distribution of 2000, 2001, 2002, and 2003 Cable Royalty Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    .... ADDRESSES: An original, five copies, and an electronic copy in Portable Document Format (PDF) on a CD of the... INFORMATION CONTACT: LaKeshia Brent, CRB Program Specialist, by telephone at (202) 707-7658, or e-mail at crb... of the major categories of copyrightable content (movies, sports programming, music, etc.) requesting...

  16. Micro Electron MicroProbe and Sample Analyzer

    NASA Technical Reports Server (NTRS)

    Manohara, Harish; Bearman, Gregory; Douglas, Susanne; Bronikowski, Michael; Urgiles, Eduardo; Kowalczyk, Robert; Bryson, Charles

    2009-01-01

    A proposed, low-power, backpack-sized instrument, denoted the micro electron microprobe and sample analyzer (MEMSA), would serve as a means of rapidly performing high-resolution microscopy and energy-dispersive x-ray spectroscopy (EDX) of soil, dust, and rock particles in the field. The MEMSA would be similar to an environmental scanning electron microscope (ESEM) but would be much smaller and designed specifically for field use in studying effects of geological alteration at the micrometer scale. Like an ESEM, the MEMSA could be used to examine uncoated, electrically nonconductive specimens. In addition to the difference in size, other significant differences between the MEMSA and an ESEM lie in the mode of scanning and the nature of the electron source.

  17. Thrust and Performance Study of Micro Pulsed Plasma Thrusters

    DTIC Science & Technology

    2010-03-01

    Due to the high- voltage potential, numerous electrons are able to collect in a small area. As the collection of the electrons grows, the ...quasi- neutral plasma removes the need to have a second emitter of free electrons to neutralize the plasma like in the Hall thrusters. PPTs and µPPTs...surface of the cathode. The micro-protrusions

  18. 21 CFR 1305.29 - Reporting to DEA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Reporting to DEA. 1305.29 Section 1305.29 Food and... SUBSTANCES Electronic Orders § 1305.29 Reporting to DEA. A supplier must, for each electronic order filled, forward either a copy of the electronic order or an electronic report of the order in a format that DEA...

  19. 21 CFR 1305.29 - Reporting to DEA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Reporting to DEA. 1305.29 Section 1305.29 Food and... SUBSTANCES Electronic Orders § 1305.29 Reporting to DEA. A supplier must, for each electronic order filled, forward either a copy of the electronic order or an electronic report of the order in a format that DEA...

  20. Characterization of a microDiamond detector in high-dose-per-pulse electron beams for intra operative radiation therapy.

    PubMed

    Di Venanzio, C; Marinelli, Marco; Tonnetti, A; Verona-Rinati, G; Falco, M D; Pimpinella, M; Ciccotelli, A; De Stefano, S; Felici, G; Marangoni, F

    2015-12-01

    To characterize a synthetic diamond dosimeter (PTW Freiburg microDiamond 60019) in high dose-per-pulse electron beams produced by an Intra Operative Radiation Therapy (IORT) dedicated accelerator. The dosimetric properties of the microDiamond were assessed under 6, 8 and 9 MeV electron beams by a NOVAC11 mobile accelerator (Sordina IORT Technologies S.p.A.). The characterization was carried out with dose-per-pulse ranging from 26 to 105 mGy per pulse. The microDiamond performance was compared with an Advanced Markus ionization chamber and a PTW silicon diode E in terms of dose linearity, percentage depth dose (PDD) curves, beam profiles and output factors. A good linearity of the microDiamond response was verified in the dose range from 0.2 Gy to 28 Gy. A sensitivity of 1.29 nC/Gy was measured under IORT electron beams, resulting within 1% with respect to the one obtained in reference condition under (60)Co gamma irradiation. PDD measurements were found in agreement with the ones by the reference dosimeters, with differences in R50 values below 0.3 mm. Profile measurements evidenced a high spatial resolution of the microDiamond, slightly worse than the one of the silicon diode. The penumbra widths measured by the microDiamond resulted approximately 0.5 mm larger than the ones by the Silicon diode. Output factors measured by the microDiamond were found within 2% with those obtained by the Advanced Markus down to 3 cm diameter field sizes. The microDiamond dosimeter was demonstrated to be suitable for precise dosimetry in IORT applications under high dose-per-pulse conditions. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  1. 76 FR 41822 - In the Matter of Certain Toner Cartridges and Components Thereof; Notice of Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... Electronics Co., Ltd of Chungchongbuk-do, South Korea; Huizhou Jahwa Electronics Co., Ltd. of Guangdong Province, China; Copy Technologies, Inc. of Atlanta, Georgia; Laser Toner Technology, Inc. of Atlanta...

  2. Micro-wrinkling and delamination-induced buckling of stretchable electronic structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oyewole, O. K.; Department of Materials Science and Engineering, Kwara State University, Malete, P.M.B 1530, Ilorin, Kwara State; Yu, D.

    This paper presents the results of experimental and theoretical/computational micro-wrinkles and buckling on the surfaces of stretchable poly-dimethylsiloxane (PDMS) coated with nano-scale Gold (Au) layers. The wrinkles and buckles are formed by the unloading of pre-stretched PDMS/Au structure after the evaporation of nano-scale Au layers. They are then characterized using atomic force microscopy and scanning electron microscopy. The critical stresses required for wrinkling and buckling are analyzed using analytical models. The possible interfacial cracking that can occur along with film buckling is also studied using finite element simulations of the interfacial crack growth. The implications of the results are discussedmore » for potential applications of micro-wrinkles and micro-buckles in stretchable electronic structures and biomedical devices.« less

  3. Concept of a tunable source of coherent THz radiation driven by a plasma modulated electron beam

    NASA Astrophysics Data System (ADS)

    Zhang, H.; Konoplev, I. V.; Doucas, G.; Smith, J.

    2018-04-01

    We have carried out numerical studies which consider the modulation of a picosecond long relativistic electron beam in a plasma channel and the generation of a micro-bunched train. The subsequent propagation of the micro-bunched beam in the vacuum area was also investigated. The same numerical model was then used to simulate the radiation arising from the interaction of the micro-bunched beam with a metallic grating. The dependence of the radiation spectrum on the parameters of the micro-bunched beam has been studied and the tunability of the radiation by the variation of the micro-bunch spacing has been demonstrated. The micro-bunch spacing can be changed easily by altering the plasma density without changing the beam energy or current. Using the results of these studies, we develop a conceptual design of a tunable source of coherent terahertz (THz) radiation driven by a plasma modulated beam. Such a source would be a potential and useful alternative to conventional vacuum THz tubes and THz free-electron laser sources.

  4. Recent Advances in Micro-/Nanostructured Metal-Organic Frameworks towards Photonic and Electronic Applications.

    PubMed

    Yang, Xiaogang; Lin, Xianqing; Zhao, Yong Sheng; Yan, Dongpeng

    2018-05-02

    Micro- and nanometer-sized metal-organic frameworks (MOFs) materials have attracted great attention due to their unique properties and various potential applications in photonics, electronics, high-density storage, chemo-, and biosensors. The study of these materials supplies insight into how the crystal structure, molecular components, and micro-/nanoscale effects can influence the performance of inorganic-organic hybrid materials. In this Minireview article, we introduce recent breakthroughs in the controlled synthesis of MOF micro-/nanomaterials with specific structures and compositions, the tunable photonic and electronic properties of which would provide a novel platform for multifunctional applications. Firstly, the design strategies for MOFs based on self-assembly and crystal engineering principles are introduced. Attention is then focused on the methods of fabrication of low-dimensional MOF micro-/nanostructures. Their new applications including two-photon excited fluorescence, multi-photon pumped lasing, optical waveguides, nonlinear optical (NLO), and field-effect transistors are also outlined. Finally, we briefly discuss perspectives on the further development of these hybrid crystalline micro-/nanomaterials. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Clinical radiation therapy measurements with a new commercial synthetic single crystal diamond detector

    PubMed Central

    Crilly, Richard

    2014-01-01

    A commercial version of a synthetic single crystal diamond detector (SCDD) in a Schottky diode configuration was recently released as the new type 60019 microDiamond detector (PTW‐Freiburg, Germany). In this study we investigate the dosimetric properties of this detector to independently confirm that findings from the developing group of the SCDDs still hold true for the commercial version of the SCDDs. We further explore if the use of the microDiamond detector can be expanded to high‐energy photon beams of up to 15 MV and to large field measurements. Measurements were performed with an Elekta Synergy linear accelerator delivering 6, 10, and 15 MV X‐rays, as well as 6, 9, 12, 15, and 20 MeV electron beams. The dependence of the microdiamond detector response on absorbed dose after connecting the detector was investigated. Furthermore, the dark current of the diamond detector was observed after irradiation. Results are compared to similar results from measurements with a diamond detector type 60003. Energy dependency was investigated, as well. Photon depth‐dose curves were measured for field sizes 3×3,10×10, and 30×30cm2. PDDs were measured with the Semiflex type 31010 detector, microLion type 31018 detector, P Diode type 60016, SRS Diode type 60018, and the microDiamond type 60019 detector (all PTW‐Freiburg). Photon profiles were measured at a depth of 10 cm. Electron depth‐dose curves normalized to the dose maximum were measured with the 14×14cm2 electron cone. PDDs were measured with a Markus chamber type 23343, an E Diode type 60017 and the microDiamond type 60019 detector (all PTW‐Freiburg). Profiles were measured with the E Diode and microDiamond at half of D90,D90,D70, and D50 depths and for electron cone sizes of 6×6cm2, 14×14cm2, and 20×20cm2. Within a tolerance of 0.5% detector response of the investigated detector was stable without any preirradiation. After preirradition with approximately 250 cGy the detector response was stable within 0.1%. A dark current after irradiation was not observed. The microDiamond detector shows no energy dependence in high energy photon or electron dosimetry. Electron PDD measurements with the E Diode and microDiamond are in good agreement. However, compared to E Diode measurements, dose values in the bremsstrahlungs region are about 0.5% lower when measured with the microDiamond detector. Markus detector measurements agree with E Diode measurements in the bremsstrahlungs region. For depths larger than dmax, depth‐dose curves of photon beams measured with the microDiamond detector are in close agreement to those measured with the microLion detector for small fields and with those measured with a Semiflex 0.125 cc ionization chamber for large fields. Differences are in the range of 0.25% and less. For profile measurements, microDiamond detector measurements agree well with microLion and P Diode measurements in the high‐dose region of the profile and the penumbra region. For areas outside the open field, P Diode measurements are about 0.5%–1.0% higher than microDiamond and microLion measurements. Thus it becomes evident that the investigated diamond detector (type 60019) is suitable for a wide range of applications in high‐energy photon and electron dosimetry and is interesting for relative, as well as absolute, dosimetry. PACS numbers: 00.06, 80.87 PMID:25493512

  6. Conversion of school nurse policy and procedure manual to electronic format.

    PubMed

    Randall, Joellyn; Knee, Rachel; Galemore, Cynthia

    2006-10-01

    Policy and procedure manuals are essential to establishing standards of practice and ensuring quality of care to students and families. The Olathe District Schools (Kansas) Technology Department created the Virtual File Cabinet to provide online access to employee policies, school board policies, forms, and other documents. A task force of school nurses was formed to convert the nursing department's policies, procedures, protocols, and forms from hard copy to electronic format and make them available on the district's Virtual File Cabinet. Having the policy and procedure manuals in electronic format allows for quick access and ease in updating information, thereby guaranteeing the school nurses have access to the most current information. Cost savings were realized by reducing the amount of paper and staff time needed to copy, collate, and assemble materials.

  7. Development and Validation of a Real-Time PCR for Detection of Pathogenic Leptospira Species in Clinical Materials

    PubMed Central

    Ahmed, Ahmed; Engelberts, Mirjam F. M.; Boer, Kimberly R.; Ahmed, Niyaz; Hartskeerl, Rudy A.

    2009-01-01

    Available serological diagnostics do not allow the confirmation of clinically suspected leptospirosis at the early acute phase of illness. Several conventional and real-time PCRs for the early diagnosis of leptospirosis have been described but these have been incompletely evaluated. We developed a SYBR Green-based real-time PCR targeting secY and validated it according to international guidelines. To determine the analytical specificity, DNA from 56 Leptospira strains belonging to pathogenic, non-pathogenic and intermediate Leptospira spp. as well as 46 other micro-organisms was included in this study. All the pathogenic Leptospira gave a positive reaction. We found no cross-reaction with saprophytic Leptospira and other micro-organisms, implying a high analytical specificity. The analytical sensitivity of the PCR was one copy per reaction from cultured homologous strain M 20 and 1.2 and 1.5 copy for heterologous strains 1342 K and Sarmin, respectively. In spiked serum & blood and kidney tissue the sensitivity was 10 and 20 copies for M 20, 15 and 30 copies for 1342 K and 30 and 50 copies for Sarmin. To determine the diagnostic sensitivity (DSe) and specificity (DSp), clinical blood samples from 26 laboratory-confirmed and 107 negative patients suspected of leptospirosis were enrolled as a prospective consecutive cohort. Based on culture as the gold standard, we found a DSe and DSp of 100% and 93%, respectively. All eight PCR positive samples that had a negative culture seroconverted later on, implying a higher actual DSp. When using culture and serology as the gold standard, the DSe was lower (89%) while the DSp was higher (100%). DSe was 100% in samples collected within the first – for treatment important - 4 days after onset of the illness. Reproducibility and repeatability of the assay, determined by blind testing kidney samples from 20 confirmed positive and 20 negative rodents both appeared 100%. In conclusion we have described for the first time the development of a robust SYBR Green real-time PCR for the detection of pathogenic Leptospira combined with a detailed assessment of its clinical accuracy, thus providing a method for the early diagnosis of leptospirosis with a well-defined satisfactory performance. PMID:19763264

  8. 76 FR 32198 - Science Advisory Board Staff Office Notification of a Joint Public Meeting of the Chartered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... meeting. Written statements should be supplied to the DFO in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, MS Word, WordPerfect, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are...

  9. 17 CFR 240.17Ad-7 - Record retention.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... electronic or micrographic media and may be preserved in those formats for the time required by § 240.17Ad-7... substitute for the hard copy records required to be maintained pursuant to § 240.17Ad-6. (1) For purposes of..., in escrow with an independent third party and keep current a copy of the physical and logical format...

  10. 76 FR 4346 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... their consideration. Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format...

  11. 75 FR 4816 - Science Advisory Board Staff Office; Notification of Two Public Teleconferences of the Chartered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to provide...

  12. 75 FR 80048 - Science Advisory Board Staff Office; Notification of an Upcoming Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... be supplied to the DFO in the following formats: One hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format). Submitters are requested to provide two...

  13. 75 FR 37793 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... supplied to the DFO in the following formats: One hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format). Submitters are requested to provide two versions...

  14. 75 FR 1381 - Science Advisory Board Staff Office; Notification of a Public Teleconference of the Clean Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... supplied to the DFO in the following formats: one hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, MS Word, WordPerfect, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to provide versions of each...

  15. 76 FR 16769 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... statements should be supplied to the DFO in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are requested to provide...

  16. 75 FR 62386 - Science Advisory Board Staff Office; Notification of Two Public Teleconferences of the Science...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    .... Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to...

  17. 76 FR 11245 - Science Advisory Board Staff Office; Notification of Two Public Teleconferences of the Science...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... their consideration. Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format...

  18. 76 FR 39813 - Notice of Funding Availability of Applications (NOFA) for Section 514 Farm Labor Housing Loans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ...- application. If leveraged funds are in the form of tax credits, the applicant must document that it has... provide an electronic copy of all hard copy forms and documents submitted in the pre-application/ application package as requested by this Notice. The forms and documents must be submitted to the appropriate...

  19. 75 FR 39975 - Applications and Amendments to Facility Operating Licenses Involving No Significant Hazards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... events. In WCAP-17072-P, leakage is modeled as flow through a porous medium via the use of the Darcy... cases to mail copies on electronic storage media. Participants may not submit paper copies of their...-mail at [email protected] , or by a toll-free call at (866) 672-7640. The NRC Meta System Help Desk...

  20. 76 FR 5614 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... to contact of the tube with the tubesheet. The leakage is modeled as flow through a porous medium... cases to mail copies on electronic storage media. Participants may not submit paper copies of their...-mail at [email protected] , or by a toll-free call at 1-866- 672-7640. The NRC Meta System Help...

  1. miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments.

    PubMed

    Hackenberg, Michael; Sturm, Martin; Langenberger, David; Falcón-Pérez, Juan Manuel; Aransay, Ana M

    2009-07-01

    Next-generation sequencing allows now the sequencing of small RNA molecules and the estimation of their expression levels. Consequently, there will be a high demand of bioinformatics tools to cope with the several gigabytes of sequence data generated in each single deep-sequencing experiment. Given this scene, we developed miRanalyzer, a web server tool for the analysis of deep-sequencing experiments for small RNAs. The web server tool requires a simple input file containing a list of unique reads and its copy numbers (expression levels). Using these data, miRanalyzer (i) detects all known microRNA sequences annotated in miRBase, (ii) finds all perfect matches against other libraries of transcribed sequences and (iii) predicts new microRNAs. The prediction of new microRNAs is an especially important point as there are many species with very few known microRNAs. Therefore, we implemented a highly accurate machine learning algorithm for the prediction of new microRNAs that reaches AUC values of 97.9% and recall values of up to 75% on unseen data. The web tool summarizes all the described steps in a single output page, which provides a comprehensive overview of the analysis, adding links to more detailed output pages for each analysis module. miRanalyzer is available at http://web.bioinformatics.cicbiogune.es/microRNA/.

  2. Preparation, characterization and nonlinear absorption studies of cuprous oxide nanoclusters, micro-cubes and micro-particles

    NASA Astrophysics Data System (ADS)

    Sekhar, H.; Narayana Rao, D.

    2012-07-01

    Cuprous oxide nanoclusters, micro-cubes and micro-particles were successfully synthesized by reducing copper(II) salt with ascorbic acid in the presence of sodium hydroxide via a co-precipitation method. The X-ray diffraction and FTIR studies revealed that the formation of pure single-phase cubic. Raman and EPR spectral studies show the presence of CuO in as-synthesized powders of Cu2O. Transmission electron microscopy and field emission scanning electron microscopy data revealed that the morphology evolves from nanoclusters to micro-cubes and micro-particles by increasing the concentration of NaOH. Linear optical measurements show absorption peak maximum shifts towards red with changing morphology from nanoclusters to micro-cubes and micro-particles. The nonlinear optical properties were studied using open aperture Z-scan technique with 532 nm 6 ns laser pulses. Samples-exhibited both saturable as well as reverse saturable absorption. Due to confinement effects (enhanced band gap), we observed enhanced nonlinear absorption coefficient (β) in the case of nanoclusters compared to their micro-cubes and micro-particles.

  3. 75 FR 52551 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... Dayton, OH; Jahwa Electronics Co., Ltd. of Chungchongbuk-do, South Korea; Huizhou Jahwa Electronics Co., Ltd of Guangdong Province, China; Copy Technologies, Inc. of Atlanta, GA; Laser Toner Technology, Inc...

  4. Fabrication of smooth patterned structures of refractory metals, semiconductors, and oxides via template stripping.

    PubMed

    Park, Jong Hyuk; Nagpal, Prashant; McPeak, Kevin M; Lindquist, Nathan C; Oh, Sang-Hyun; Norris, David J

    2013-10-09

    The template-stripping method can yield smooth patterned films without surface contamination. However, the process is typically limited to coinage metals such as silver and gold because other materials cannot be readily stripped from silicon templates due to strong adhesion. Herein, we report a more general template-stripping method that is applicable to a larger variety of materials, including refractory metals, semiconductors, and oxides. To address the adhesion issue, we introduce a thin gold layer between the template and the deposited materials. After peeling off the combined film from the template, the gold layer can be selectively removed via wet etching to reveal a smooth patterned structure of the desired material. Further, we demonstrate template-stripped multilayer structures that have potential applications for photovoltaics and solar absorbers. An entire patterned device, which can include a transparent conductor, semiconductor absorber, and back contact, can be fabricated. Since our approach can also produce many copies of the patterned structure with high fidelity by reusing the template, a low-cost and high-throughput process in micro- and nanofabrication is provided that is useful for electronics, plasmonics, and nanophotonics.

  5. Patterns, correlates, and reduction of homework copying

    NASA Astrophysics Data System (ADS)

    Palazzo, David J.; Lee, Young-Jin; Warnakulasooriya, Rasil; Pritchard, David E.

    2010-06-01

    Submissions to an online homework tutor were analyzed to determine whether they were copied. The fraction of copied submissions increased rapidly over the semester, as each weekly deadline approached and for problems later in each assignment. The majority of students, who copied less than 10% of their problems, worked steadily over the three days prior to the deadline, whereas repetitive copiers (those who copied >30% of their submitted problems) exerted little effort early. Importantly, copying homework problems that require an analytic answer correlates with a 2(σ) decline over the semester in relative score for similar problems on exams but does not significantly correlate with the amount of conceptual learning as measured by pretesting and post-testing. An anonymous survey containing questions used in many previous studies of self-reported academic dishonesty showed ˜1/3 less copying than actually was detected. The observed patterns of copying, free response questions on the survey, and interview data suggest that time pressure on students who do not start their homework in a timely fashion is the proximate cause of copying. Several measures of initial ability in math or physics correlated with copying weakly or not at all. Changes in course format and instructional practices that previous self-reported academic dishonesty surveys and/or the observed copying patterns suggested would reduce copying have been accompanied by more than a factor of 4 reduction of copying from ˜11% of all electronic problems to less than 3%. As expected (since repetitive copiers have approximately three times the chance of failing), this was accompanied by a reduction in the overall course failure rate. Survey results indicate that students copy almost twice as much written homework as online homework and show that students nationally admit to more academic dishonesty than MIT students.

  6. PREFACE: MicroTherm' 2013 - Microtechnology and Thermal Problems in Electronics

    NASA Astrophysics Data System (ADS)

    Lisik, Zbigniew; Raj, Ewa

    2014-04-01

    MicroTherm is an International Conference on Microtechnology and Thermal Problems in Electronics organised as a cyclic event since 1996. The success of the first seminar, which was devoted mainly to thermal management aspects, and the successive conferences have led us to the tenth edition. Since the first meeting, the scope of the conference has expanded, following the progress of electronics. Now, it covers subjects connected with extreme temperature, electronics, sensors and measurement techniques, modelling, simulation, wide band-gap materials, packaging and reliability, renewable energy sources and photonics with special emphasis on microelectronic technologies. MicroTherm' 2013 was held in Lodz, Poland, on 25-28 June 2013. The programme consistied of invited talks and nine regular sessions in the form of planar discussions and poster presentations, including a Students' Session. The Students' session gave an opportunity for students and young researchers to present their first achievements in the field of science. The next MicroTherm Conference is going to be held on 22-25 June 2015, in Lodz — a beautiful, post-industrial city located in the centre of Poland. Please, feel invited to MicroTherm' 2015 (www.microtherm.dsod.pl). Ewa Raj and Zbigniew Lisik Editors

  7. 14 CFR 1206.200 - Types of records to be made available.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... instructions regarding the scope and contents of all papers, reports, or examinations; (4) Substantive rules of... instructions to staff that affect a member of the public; (iv) Copies of all records, regardless of form or... electronically, through an electronic reading room and in electronic forms or formats. (ii) In connection with...

  8. CTEPP STANDARD OPERATING PROCEDURE FOR MAINTAINING AND RECORDING ELECTRONIC CHAIN-OF-CUSTODY (SOP-4.11)

    EPA Science Inventory

    The method for maintaining and recording electronic Chain-of-Custody (CoC) Records for CTEPP samples is summarized in this SOP. The CoC Records that will be logged electronically include the creation of a sample's identification code, bar code labels, and hard-copy CoC document...

  9. 78 FR 49280 - 30-Day Notice of Proposed Information Collection: Third-Party Documentation Facsimile Transmittal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... calling the toll-free Federal Relay Service at (800) 877-8339. This is not a toll- free number. Copies of... produces an electronic version of the document that will be matched with the electronic application....g., permitting electronic submission of responses. HUD encourages interested parties to submit...

  10. Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis.

    PubMed

    Refinetti, Paulo; Arstad, Christian; Thilly, William G; Morgenthaler, Stephan; Ekstrøm, Per Olaf

    2017-01-01

    The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occurred in a founding cell and spread through cell division. Micro-anatomical dissection of a tumor coupled with assays for mitochondrial point mutations permits new insights into this growth process. More generally, the ability to detect and trace, at a histological level, somatic mitochondrial mutations in human tissues and tumors, makes these mutations into markers for lineage tracing. A tumor was first sampled by a large punch biopsy and scanned for any significant degree of heteroplasmy in a set of sequences containing known mutational hotspots of the mitochondrial genome. A heteroplasmic tumor was sliced at a 12 μm thickness and placed on membranes. Laser capture micro-dissection was used to take 25000 μm 2 subsamples or spots. After DNA amplification, cycling temperature capillary electrophoresis (CTCE) was used on the laser captured samples to quantify mitochondrial mutant fractions. Of six testicular tumors studied, one, a Leydig tumor, was discovered to carry a detectable degree of heteroplasmy for two separate point mutations: a C → T mutation at bp 64 and a T → C mutation found at bp 152. From this tumor, 381 spots were sampled with laser capture micro-dissection. The ordered distribution of spots exhibited a wide range of fractions of the mutant sequences from 0 to 100% mutant copies. The two mutations co-distributed in the growing tumor indicating they were present on the same genome copies in the founding cell. Laser capture microdissection of sliced tumor samples coupled with CTCE-based point mutation assays provides an effective and practical means to obtain maps of mitochondrial mutational heteroplasmy within human tumors.

  11. PCR-based detection of micro-organisms in extreme environments during the EuroGeoMars MDRS campaign

    NASA Astrophysics Data System (ADS)

    Thiel, Cora S.; Ullrich, Oliver

    Deoxyribonucleic acid (DNA) is found in all known living organisms and some viruses on earth. The main function of DNA molecules is the long-term storage of genetic information. They are passed on from generation to generation as the hereditary material. The polymerase chain reaction (PCR) is a revolutionary technique which allows amplifying a single or few copies of DNA molecules across several orders of magnitude, generating millions of copies of the original DNA fragment allowing detection of minimal traces of DNA. The compactness of the nowadays PCR instruments makes routine sample analysis possible with only a minimum of laboratory space. Our goal was to establish a routine for detection of DNA from micro-organisms based on the effective but also robust and simple PCR technique during the EuroGeoMars simula-tion campaign at The Mars Society's Mars Desert Research Station (MDRS) in February 2009. During the MDRS simulation we were able to show that it is possible to establish a minimal molecular biology lab in the habitat for an immediate on-site analysis by PCR after sample collection. Soil and water samples were taken from different locations and soil depths. The sample analysis was started immediately after returning to the habitat and was completed dur-ing the following days. DNA was isolated from micro-organisms and was used as a template for PCR analysis of the highly conserved ribosomal DNA to identify representatives of the different groups of micro-organisms (archaea, bacteria, eukaryotes). PCR products were visualized by agarose gel electrophoresis and documented by UV-transilluminator and digital camera. For the first time it was possible to demonstrate a direct on-site DNA analysis by PCR at MDRS, situated in an extreme environment that functions as a model for preparation and optimization of techniques to be used for future Mars exploration.

  12. Integrated Molecular Characterization of Uterine Carcinosarcoma.

    PubMed

    Cherniack, Andrew D; Shen, Hui; Walter, Vonn; Stewart, Chip; Murray, Bradley A; Bowlby, Reanne; Hu, Xin; Ling, Shiyun; Soslow, Robert A; Broaddus, Russell R; Zuna, Rosemary E; Robertson, Gordon; Laird, Peter W; Kucherlapati, Raju; Mills, Gordon B; Weinstein, John N; Zhang, Jiashan; Akbani, Rehan; Levine, Douglas A

    2017-03-13

    We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest among all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were identified. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. 40 CFR 35.6705 - Records retention.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... This requirement applies to all financial and programmatic records, supporting documents, statistical... ten-year period, whichever is later. (c) Substitution of an unalterable electronic format. An unalterable electronic format, acceptable to EPA, may be substituted for the original records. The copying of...

  14. 40 CFR 35.6705 - Records retention.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... This requirement applies to all financial and programmatic records, supporting documents, statistical... ten-year period, whichever is later. (c) Substitution of an unalterable electronic format. An unalterable electronic format, acceptable to EPA, may be substituted for the original records. The copying of...

  15. 40 CFR 35.6705 - Records retention.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... This requirement applies to all financial and programmatic records, supporting documents, statistical... ten-year period, whichever is later. (c) Substitution of an unalterable electronic format. An unalterable electronic format, acceptable to EPA, may be substituted for the original records. The copying of...

  16. 40 CFR 35.6705 - Records retention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... This requirement applies to all financial and programmatic records, supporting documents, statistical... ten-year period, whichever is later. (c) Substitution of an unalterable electronic format. An unalterable electronic format, acceptable to EPA, may be substituted for the original records. The copying of...

  17. 40 CFR 35.6705 - Records retention.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... This requirement applies to all financial and programmatic records, supporting documents, statistical... ten-year period, whichever is later. (c) Substitution of an unalterable electronic format. An unalterable electronic format, acceptable to EPA, may be substituted for the original records. The copying of...

  18. 7 CFR 1409.8 - Public inspection and copying of records; applicable fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., electronic recording, transcription of the recording, or minutes of the discussion of any item on the agenda...., Washington, DC 20250. (c) The transcripts, minutes, or transcriptions of electronic recordings of a Board... of transcription or duplication. ...

  19. 7 CFR 1409.8 - Public inspection and copying of records; applicable fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., electronic recording, transcription of the recording, or minutes of the discussion of any item on the agenda...., Washington, DC 20250. (c) The transcripts, minutes, or transcriptions of electronic recordings of a Board... of transcription or duplication. ...

  20. Micro and Nano Systems for Space Exploration

    NASA Technical Reports Server (NTRS)

    Manohara, Harish

    2007-01-01

    This slide presentation reviews the use of micro and nano systems in Space exploration. Included are: an explanation of the rationales behind nano and micro technologies for space exploration, a review of how the devices are fabricated, including details on lithography with more information on Electron Beam (E-Beam) lithography, and X-ray lithography, a review of micro gyroscopes and inchworm Microactuator as examples of the use of MicroElectoMechanical (MEMS) technology. Also included is information on Carbon Nanotubes, including a review of the CVD growth process. These micro-nano systems have given rise to the next generation of miniature X-ray Diffraction, X-ray Fluorescence instruments, mass spectrometers, and terahertz frequency vacuum tube oscillators and amplifiers, scanning electron microscopes and energy dispersive x-ray spectroscope. The nanotechnology has also given rise to coating technology, such as silicon nanotip anti-reflection coating.

  1. Surface study of graphene ink for fine solid lines printed on BOPP Substrate in micro-flexographic printing using XPS analysis technique

    NASA Astrophysics Data System (ADS)

    Hassan, S.; Yusof, M. S.; Embong, Z.; Ding, S.; Maksud, M. I.

    2018-01-01

    Micro-flexographic printing is a combination of flexography and micro-contact printing technique. It is a new printing method for fine solid lines printing purpose. Graphene material has been used as depositing agent or printing ink in other printing technique like inkjet printing. This graphene ink is printed on biaxially oriented polypropylene (BOPP) by using Micro-flexographic printing technique. The choose of graphene as a printing ink is due to its wide application in producing electronic and micro-electronic devices such as Radio-frequency identification (RFID) and printed circuit board. The graphene printed on the surface of BOPP substrate was analyzed using X-Ray Photoelectron Spectroscopy (XPS). The positions for each synthetic component in the narrow scan are referred to the electron binding energy (eV). This research is focused on two narrow scan regions which are C 1s and O 1s. Further discussion of the narrow scan spectrum will be explained in detail. From the narrow scan analysis, it is proposed that from the surface adhesive properties of graphene, it is suitable as an alternative printing ink medium for Micro-flexographic printing technique in printing multiple fine solid lines at micro to nano scale feature.

  2. Tissue Oxygenation Monitoring using Resonance Raman Spectroscopy during Hemorrhage

    DTIC Science & Technology

    2013-12-27

    saturation measurements using resonance Raman intravital micros- copy. Am J Physiol Heart Circ Physiol. 2005;289:H488 H495. 14. Ward KR, Ivatury RR, Barbee...Nighswander-Rempel SP, Kupriyanov VV, Shaw RA. Relative contribu- tions of hemoglobin and myoglobin to near-infrared spectroscopic images of cardiac tissue...DC, Shapiro NI. The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image

  3. Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.

    PubMed

    Marrale, Maurizio; Albanese, Nadia Ninfa; Calì, Francesco; Romano, Valentino

    2014-01-01

    Autism Spectrum Disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies have investigated the role of de novo Copy Number Variants (CNVs) and microRNAs as important but distinct etiological factors in ASD. We developed a novel computational procedure to assess the potential pathogenic role of microRNA genes overlapping de novo CNVs in ASD patients. Here we show that for chromosomes # 1, 2 and 22 the actual number of miRNA loci affected by de novo CNVs in patients was found significantly higher than that estimated by Monte Carlo simulation of random CNV events. Out of 24 miRNA genes over-represented in CNVs from these three chromosomes only hsa-mir-4436b-1 and hsa-mir-4436b-2 have not been detected in CNVs from non-autistic subjects as reported in the Database of Genomic Variants. Altogether the results reported in this study represent a first step towards a full understanding of how a dysregulated expression of the 24 miRNAs genes affect neurodevelopment in autism. We also propose that the procedure used in this study can be effectively applied to CNVs/miRNA genes association data in other genomic disorders beyond autism.

  4. Assessing consumption of bioactive micro-particles by filter-feeding Asian carp

    USGS Publications Warehouse

    Jensen, Nathan R.; Amberg, Jon J.; Luoma, James A.; Walleser, Liza R.; Gaikowski, Mark P.

    2012-01-01

    Silver carp Hypophthalmichthys molitrix (SVC) and bighead carp H. nobilis (BHC) have impacted waters in the US since their escape. Current chemical controls for aquatic nuisance species are non-selective. Development of a bioactive micro-particle that exploits filter-feeding habits of SVC or BHC could result in a new control tool. It is not fully understood if SVC or BHC will consume bioactive micro-particles. Two discrete trials were performed to: 1) evaluate if SVC and BHC consume the candidate micro-particle formulation; 2) determine what size they consume; 3) establish methods to evaluate consumption of filter-feeders for future experiments. Both SVC and BHC were exposed to small (50-100 μm) and large (150-200 μm) micro-particles in two 24-h trials. Particles in water were counted electronically and manually (microscopy). Particles on gill rakers were counted manually and intestinal tracts inspected for the presence of micro-particles. In Trial 1, both manual and electronic count data confirmed reductions of both size particles; SVC appeared to remove more small particles than large; more BHC consumed particles; SVC had fewer overall particles in their gill rakers than BHC. In Trial 2, electronic counts confirmed reductions of both size particles; both SVC and BHC consumed particles, yet more SVC consumed micro-particles compared to BHC. Of the fish that ate micro-particles, SVC consumed more than BHC. It is recommended to use multiple metrics to assess consumption of candidate micro-particles by filter-feeders when attempting to distinguish differential particle consumption. This study has implications for developing micro-particles for species-specific delivery of bioactive controls to help fisheries, provides some methods for further experiments with bioactive micro-particles, and may also have applications in aquaculture.

  5. Critical Infrastructure References: Documented Literature Search

    DTIC Science & Technology

    2012-10-01

    the literature search document can be a resource for DRDC and external partners. Future plans: At present, the electronic copies of the reference...Personal Information Protection and Electronic Documents Act (S.C. 2000, c. 5) Title: Personal Information Protection and Electronic Documents Act (S.C...2011 Overview: • "An Act to support and promote electronic commerce by protecting personal information that is collected, used or disclosed in

  6. Managing the Manpower Aspects of Applying Micro-Electronics Technology.

    ERIC Educational Resources Information Center

    Thornton, P.; Routledge, C.

    1980-01-01

    Outlines major effects that the application of micro-electronics devices in products/processes and in office systems will have on future manpower and skill requirements in manufacturing organizations. Identifies the type of problems these changes will pose for manpower managers. Provides general guidelines for the successful management of these…

  7. Characterization of spiral ganglion neurons cultured on silicon micro-pillar substrates for new auditory neuro-electronic interfaces.

    PubMed

    Mattotti, M; Micholt, L; Braeken, D; Kovačić, D

    2015-04-01

    One of the strategies to improve cochlear implant technology is to increase the number of electrodes in the neuro-electronic interface. The objective was to characterize in vitro cultures of spiral ganglion neurons (SGN) cultured on surfaces of novel silicon micro-pillar substrates (MPS). SGN from P5 rat pups were cultured on MPS with different micro-pillar widths (1-5.6 μm) and spacings (0.6-15 μm) and were compared with control SGN cultures on glass coverslips by immunocytochemistry and scanning electron microscopy (SEM). Overall, MPS support SGN growth equally well as the control glass surfaces. Micro-pillars of a particular size-range (1.2-2.4 μm) were optimal in promoting SGN presence, neurite growth and alignment. On this specific micro-pillar size, more SGN were present, and neurites were longer and more aligned. SEM pictures highlight how cells on micro-pillars with smaller spacings grow directly on top of pillars, while at wider spacings (from 3.2 to 15 μm) they grow on the bottom of the surface, losing contact guidance. Further, we found that MPS encourage more monopolar and bipolar SGN morphologies compared to the control condition. Finally, MPS induce longest neurite growth with minimal interaction of S100+ glial cells. These results indicate that silicon micro-pillar substrates create a permissive environment for the growth of primary auditory neurons promoting neurite sprouting and are a promising technology for future high-density three-dimensional CMOS-based auditory neuro-electronic interfaces.

  8. The Integrity of Digital Information: Mechanics and Definitional Issues.

    ERIC Educational Resources Information Center

    Lynch, Clifford A.

    1994-01-01

    Considers issues regarding the migration of a system of literature into electronic formats. Highlights include integrity in an information distribution system; digest technology; tracings that permit detection of copied digital objects; verifying sources; digital signature technology and cryptography; electronic publishing; and intellectual…

  9. Off the Shelf: Trends in the Purchase and Use of Electronic Reference Books

    ERIC Educational Resources Information Center

    Korah, Abe; Cassidy, Erin; Elmore, Eric; Jerabek, Ann

    2009-01-01

    What is the future direction of reference books? What types of policies are libraries implementing regarding the purchase of electronic reference books? Are libraries still buying hard copy reference items when an electronic equivalent is available? This paper discusses a national survey of libraries regarding the purchase and use of electronic…

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sankar, M. S. Ravi, E-mail: rameshg.phy@pondiuni.edu; Gangineni, Ramesh Babu, E-mail: rameshg.phy@pondiuni.edu

    The present work reveals soft lithography strategy based on self assembly and replica molding for carrying out micro and nanofabrication. It provides a convenient, effective and very low cost method for the formation and manufacturing of micro and nano structures. Al-layer of compact disc (sony CD-R) used as a stamp with patterned relief structures to generate patterns and structures with pattern size of 100nm height, 1.7 μm wide. In literature, PDMS (Polydimethylsiloxane) solution is widely used to get negative copy of the Al-layer. In this work, we have used inexpensive white glue (Polyvinylacetate + water), 15gm (□5) and PVDF (Polyvinylidenemore » difluoride) spin coated films and successfully transferred the nano patterns of Al layer on to white glue and PVDF films.« less

  11. Comparing the detection of iron-based pottery pigment on a carbon-coated sherd by SEM-EDS and by Micro-XRF-SEM.

    PubMed

    Pendleton, Michael W; Washburn, Dorothy K; Ellis, E Ann; Pendleton, Bonnie B

    2014-03-01

    The same sherd was analyzed using a scanning electron microscope with energy dispersive spectroscopy (SEM-EDS) and a micro X-ray fluorescence tube attached to a scanning electron microscope (Micro-XRF-SEM) to compare the effectiveness of elemental detection of iron-based pigment. To enhance SEM-EDS mapping, the sherd was carbon coated. The carbon coating was not required to produce Micro-XRF-SEM maps but was applied to maintain an unbiased comparison between the systems. The Micro-XRF-SEM analysis was capable of lower limits of detection than that of the SEM-EDS system, and therefore the Micro-XRF-SEM system could produce elemental maps of elements not easily detected by SEM-EDS mapping systems. Because SEM-EDS and Micro-XRF-SEM have been used for imaging and chemical analysis of biological samples, this comparison of the detection systems should be useful to biologists, especially those involved in bone or tooth (hard tissue) analysis.

  12. Comparing the Detection of Iron-Based Pottery Pigment on a Carbon-Coated Sherd by SEM-EDS and by Micro-XRF-SEM

    PubMed Central

    Pendleton, Michael W.; Washburn, Dorothy K.; Ellis, E. Ann; Pendleton, Bonnie B.

    2014-01-01

    The same sherd was analyzed using a scanning electron microscope with energy dispersive spectroscopy (SEM-EDS) and a micro X-ray fluorescence tube attached to a scanning electron microscope (Micro-XRF-SEM) to compare the effectiveness of elemental detection of iron-based pigment. To enhance SEM-EDS mapping, the sherd was carbon coated. The carbon coating was not required to produce Micro-XRF-SEM maps but was applied to maintain an unbiased comparison between the systems. The Micro-XRF-SEM analysis was capable of lower limits of detection than that of the SEM-EDS system, and therefore the Micro-XRF-SEM system could produce elemental maps of elements not easily detected by SEM-EDS mapping systems. Because SEM-EDS and Micro-XRF-SEM have been used for imaging and chemical analysis of biological samples, this comparison of the detection systems should be useful to biologists, especially those involved in bone or tooth (hard tissue) analysis. PMID:24600333

  13. Indentation-Enabled In Situ Mechanical Characterization of Micro/Nanopillars in Electron Microscopes

    NASA Astrophysics Data System (ADS)

    Guo, Qiang; Fu, Xidan; Guo, Xiaolei; Liu, Zhiying; Shi, Yan; Zhang, Di

    2018-04-01

    Indentation-enabled micro/nanomechanical characterization of small-scale specimens provides powerful new tools for probing materials properties that were once unattainable by conventional experimental methods. Recent advancement in instrumentation further allows mechanical testing to be carried out in situ in electron microscopes, with high spatial and temporal resolution. This review discusses the recent development of nanoindentation-enabled in situ mechanical testing in electron microscopes, with an emphasis on the study of micro/nanopillars. Focus is given to novel applications beyond simple compressive and tensile testing that have been developed in the past few years, and limitations and possible future research directions in this field are proposed and discussed.

  14. Safe Practices for Copy and Paste in the EHR

    PubMed Central

    Lehmann, Christoph U.; Michel, Jeremy; Solomon, Ronni; Possanza, Lorraine; Gandhi, Tejal

    2017-01-01

    Summary Background Copy and paste functionality can support efficiency during clinical documentation, but may promote inaccurate documentation with risks for patient safety. The Partnership for Health IT Patient Safety was formed to gather data, conduct analysis, educate, and disseminate safe practices for safer care using health information technology (IT). Objective To characterize copy and paste events in clinical care, identify safety risks, describe existing evidence, and develop implementable practice recommendations for safe reuse of information via copy and paste. Methods The Partnership 1) reviewed 12 reported safety events, 2) solicited expert input, and 3) performed a systematic literature review (2010 to January 2015) to identify publications addressing frequency, perceptions/attitudes, patient safety risks, existing guidance, and potential interventions and mitigation practices. Results The literature review identified 51 publications that were included. Overall, 66% to 90% of clinicians routinely use copy and paste. One study of diagnostic errors found that copy and paste led to 2.6% of errors in which a missed diagnosis required patients to seek additional unplanned care. Copy and paste can promote note bloat, internal inconsistencies, error propagation, and documentation in the wrong patient chart. Existing guidance identified specific responsibilities for authors, organizations, and electronic health record (EHR) developers. Analysis of 12 reported copy and paste safety events was congruent with problems identified from the literature review. Conclusion Despite regular copy and paste use, evidence regarding direct risk to patient safety remains sparse, with significant study limitations. Drawing on existing evidence, the Partnership developed four safe practice recommendations: 1) Provide a mechanism to make copy and paste material easily identifiable; 2) Ensure the provenance of copy and paste material is readily available; 3) Ensure adequate staff training and education; 4) Ensure copy and paste practices are regularly monitored, measured, and assessed. PMID:28074211

  15. Safe Practices for Copy and Paste in the EHR. Systematic Review, Recommendations, and Novel Model for Health IT Collaboration.

    PubMed

    Tsou, Amy Y; Lehmann, Christoph U; Michel, Jeremy; Solomon, Ronni; Possanza, Lorraine; Gandhi, Tejal

    2017-01-11

    Copy and paste functionality can support efficiency during clinical documentation, but may promote inaccurate documentation with risks for patient safety. The Partnership for Health IT Patient Safety was formed to gather data, conduct analysis, educate, and disseminate safe practices for safer care using health information technology (IT). To characterize copy and paste events in clinical care, identify safety risks, describe existing evidence, and develop implementable practice recommendations for safe reuse of information via copy and paste. The Partnership 1) reviewed 12 reported safety events, 2) solicited expert input, and 3) performed a systematic literature review (2010 to January 2015) to identify publications addressing frequency, perceptions/attitudes, patient safety risks, existing guidance, and potential interventions and mitigation practices. The literature review identified 51 publications that were included. Overall, 66% to 90% of clinicians routinely use copy and paste. One study of diagnostic errors found that copy and paste led to 2.6% of errors in which a missed diagnosis required patients to seek additional unplanned care. Copy and paste can promote note bloat, internal inconsistencies, error propagation, and documentation in the wrong patient chart. Existing guidance identified specific responsibilities for authors, organizations, and electronic health record (EHR) developers. Analysis of 12 reported copy and paste safety events was congruent with problems identified from the literature review. Despite regular copy and paste use, evidence regarding direct risk to patient safety remains sparse, with significant study limitations. Drawing on existing evidence, the Partnership developed four safe practice recommendations: 1) Provide a mechanism to make copy and paste material easily identifiable; 2) Ensure the provenance of copy and paste material is readily available; 3) Ensure adequate staff training and education; 4) Ensure copy and paste practices are regularly monitored, measured, and assessed.

  16. A double exposed portal image comparison between electronic portal imaging hard copies and port films in radiation therapy treatment setup confirmation to determine its clinical application in a radiotherapy center.

    PubMed

    Hatherly, K E; Smylie, J C; Rodger, A; Dally, M J; Davis, S R; Millar, J L

    2001-01-01

    At the William Buckland Radiotherapy Center (WBRC), field-only electronic portal image (EPI) hard copies are used for radiation treatment field verification for whole brain, breast, chest, spine, and large pelvic fields, as determined by a previous study. A subsequent research project, addressing the quality of double exposed EPI hard copies for sites where field only EPI was not considered adequate to determine field placement, has been undertaken. The double exposed EPI hard copies were compared to conventional double exposed port films for small pelvic, partial brain, and head and neck fields and for a miscellaneous group. All double exposed EPIs were captured during routine clinical procedures using liquid ion chamber cassettes. EPI hard copies were generated using a Visiplex multi-format camera. In sites where port film remained the preferred verification format, the port films were generated as per department protocol. In addition EPIs were collected specifically for this project. Four radiation oncologists performed the evaluation of EPI and port film images independently with a questionnaire completed at each stage of the evaluation process to assess the following: Adequacy of information in the image to assess field placement. Adequacy of information for determining field placement correction. Clinician's preferred choice of imaging for field placement assessment The results indicate that double exposed EPI hard copies generally do containsufficient information to permit evaluation of field placement and can replace conventionaldouble exposed port films in a significant number of sites. These include the following:pelvis fields < 12 X 12 cm, partial brain fields, and a miscellaneous group. However forradical head and neck fields, the preferred verification image format remained port film dueto the image hard copy size and improved contrast for this media. Thus in this departmenthard copy EPI is the preferred modality of field verification for all sites except radical headand neck treatments. This should result in an increase in efficiency of workloadmanagement and patient care.

  17. Breakthrough: micro-electronic photovoltaics

    ScienceCinema

    Okandan, Murat; Gupta, Vipin

    2018-01-16

    Sandia developed tiny glitter-sized photovoltaic (PV) cells that could revolutionize solar energy collection. The crystalline silicon micro-PV cells will be cheaper and have greater efficiencies than current PV collectors. Micro-PV cells require relatively little material to form well-controlled, highly efficient devices. Cell fabrication uses common microelectric and micro-electromechanical systems (MEMS) techniques.

  18. Applications of Gas Imaging Micro-Well Detectors to an Advanced Compton Telescope

    NASA Technical Reports Server (NTRS)

    Bloser, P. F.; Hunter, S. D.; Ryan, J. M.; McConnell, M. L.; Miller, R. S.; Jackson, T. N.; Bai, B.; Jung, S.

    2003-01-01

    We present a concept for an Advanced Compton Telescope (ACT) based on the use of pixelized gas micro-well detectors to form a three-dimensional electron track imager. A micro-well detector consists of an array of individual micro-patterned proportional counters opposite a planar drift electrode. When combined with thin film transistor array readouts, large gas volumes may be imaged with very good spatial and energy resolution at reasonable cost. The third dimension is determined by timing the drift of the ionization electrons. The primary advantage of this approach is the excellent tracking of the Compton recoil electron that is possible in a gas volume. Such good electron tracking allows us to reduce the point spread function of a single incident photon dramatically, greatly improving the imaging capability and sensitivity. The polarization sensitivity, which relies on events with large Compton scattering angles, is particularly enhanced. We describe a possible ACT implementation of this technique, in which the gas tracking volume is surrounded by a CsI calorimeter, and present our plans to build and test a small prototype over the next three years.

  19. Mechanism of total electron emission yield reduction using a micro-porous surface

    NASA Astrophysics Data System (ADS)

    Ye, Ming; Wang, Dan; He, Yongning

    2017-03-01

    Suppression of the total secondary electron yield (TEY) of metal surfaces is important in many areas such as accelerator, satellite, and Hall thruster. Among TEY suppression techniques, micro-porous surfaces have been demonstrated as an effective method. In this work, we developed an analytical model that is able to obtain the contributions of TEY from both the 1st and 2nd generation secondary electrons (SEs). Calculation results show that the TEY contributed by the bottom of the hole dominates the TEY of the micro-porous surface with the aspect ratio we have chosen. Thus, we developed the following design guidance for the improvement of the TEY suppression efficiency of the micro-porous surface: either lower the TEY of the bottom or guide its SEs to the lateral side of the hole. To verify this idea, we performed the following numerical simulations: a micro-hole with its inner surfaces coated with a low TEY material and a micro-hole with nano-triangular grooves or nano-truncated cone pillars embedded at its bottom. Compared with a usual micro-hole, the proposed hybrid micro/nano structures show improved TEY suppression efficiency as expected from the analytical model. The percentage ratios of the 1st and 2nd generation SEs obtained from the simulation agree well with the predictions of the analytical model. What is more, we also present the results of the emitting angle distribution of SEs which represent remarkable deviation from the usual cosine distribution.

  20. A facile bacterial assisted electrochemical self-assembly of polypyrrole micro-pillars: towards underwater low adhesive superoleophobicity

    NASA Astrophysics Data System (ADS)

    Cheng, Zhe; Ding, Chunmei; Liu, Huan; Zhu, Ying; Jiang, Lei

    2013-12-01

    By taking advantage of bacterial extracellular electron transfer behavior, a facile method was developed to fabricate oriented polypyrrole micro-pillars (PPy-MP) with nanoscale surface roughness. Microbes acted as a living conductive template on which PPy was in situ polymerized. The as-prepared PPy-MP exhibit the distinctive underwater low adhesive superoleophobicity which is attributable to the unique hierarchical micro/nano-structures and the high surface energy by doping with inorganic small anions.By taking advantage of bacterial extracellular electron transfer behavior, a facile method was developed to fabricate oriented polypyrrole micro-pillars (PPy-MP) with nanoscale surface roughness. Microbes acted as a living conductive template on which PPy was in situ polymerized. The as-prepared PPy-MP exhibit the distinctive underwater low adhesive superoleophobicity which is attributable to the unique hierarchical micro/nano-structures and the high surface energy by doping with inorganic small anions. Electronic supplementary information (ESI) available: The shape of a water drop on PPy-MPA and cauliflower-like PPy film in air. See DOI: 10.1039/c3nr03788f

  1. Human MicroRNA Responses Predict Cytomegalovirus Replication Following Solid Organ Transplantation.

    PubMed

    Han, Sang Hoon; Kumar, Deepali; Ferreira, Victor H; Egli, Adrian; Hirsch, Hans H; Weisser, Maja; Garzoni, Christian; van Delden, Christian; Bochud, Pierre-Yves; Manuel, Oriol; Meylan, Pascal; Boggian, Katia; Husain, Shahid; Mueller, Nicolas J; Humar, Atul

    2017-02-15

    Homo sapiens mature micro-ribonucleic acid (miRNA)-200b-3p and 200c-3p are predicted to bind to 3' untranslated region of mRNA encoding human cytomegalovirus (HCMV) immediate early protein 2 (IE2). We hypothesized that expression of these miRNAs pretransplant could predict HCMV replication after solid organ transplantation (SOT). A total of 272 SOT recipients were HCMV-seropositive pretransplant and were managed using preemptive therapy. Pretransplant peripheral blood mononuclear cells were stimulated with HCMV followed by collection of RNA 1 day poststimulation. The miRNAs were quantified using real-time reverse transcription-polymerase chain reaction. Human foreskin fibroblasts were transfected with 200b-3p and 200c-3p and infected with HCMV 1 hour post-transfection. Protein was collected at 3 days postinfection (dpi) and 7 dpi underwent immunoblotting for IE2. Medians of 200b-3p and 200c-3p were significantly lower in recipients with HCMV replication (n = 144) (361.6 vs 552.6, P = .035; 3586.8 vs 12986.8 copies/μL, P = .03, respectively). Multivariate regression revealed that 200b-3p ≥100 copies/μL (odds ratio [OR]: 0.53; P = .02), was associated with less HCMV replication. Transfection with 200b-3p resulted in 2.7- and 2.5-fold decreased IE2 at 3 dpi and 7 dpi, respectively, compared to mock cells. MicroRNAs may play a biologically relevant role in controlling HCMV replication post-transplant. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  2. Reading performance with large fonts on high-resolution displays

    NASA Astrophysics Data System (ADS)

    Powers, Maureen K.; Larimer, James O.; Gille, Jennifer; Liu, Hsien-Chang

    2004-06-01

    Reading is a fundamental task and skill in many environments including business, education, and the home. Today, reading often occurs on electronic displays in addition to traditional hard copy media such as books and magazines, presenting issues of legibility and other factors that can affect human performance [1]. In fact, the transition to soft copy media for text images is often met with worker complaints about their vision and comfort while reading [2-6]. Careful comparative evaluations of reading performance across hard and soft copy device types are rare, even though they are clearly important given the rapid and substantial improvements in soft copy devices available in the marketplace over the last 5 years. To begin to fill this evaluation gap, we compared reading performance on three different soft copy devices and traditional paper. This study does not investigate comfort factors such as display location, seating comfort, and more general issues of lighting, rather we focus instead on a narrow examination of reading performance differences across display types when font sizes are large.

  3. Microstructural Evolution at Micro/Meso-Scale in an Ultrafine-Grained Pure Aluminum Processed by Equal-Channel Angular Pressing with Subsequent Annealing Treatment.

    PubMed

    Xu, Jie; Li, Jianwei; Zhu, Xiaocheng; Fan, Guohua; Shan, Debin; Guo, Bin

    2015-11-04

    Micro-forming with ultrafine-grained (UFG) materials is a promising direction for the fabrication of micro-electro-mechanical systems (MEMS) components due to the improved formability, good surface quality, and excellent mechanical properties it provides. In this paper, micro-compression tests were performed using UFG pure aluminum processed by equal-channel angular pressing (ECAP) with subsequent annealing treatment. Microstructural evolution was investigated by electron back-scattered diffraction (EBSD) and transmission electron microscopy (TEM). The results show that microstructural evolutions during compression tests at the micro/meso-scale in UFG pure Al are absolutely different from the coarse-grained (CG) materials. A lot of low-angle grain boundaries (LAGBs) and recrystallized fine grains are formed inside of the original large grains in CG pure aluminum after micro-compression. By contrast, ultrafine grains are kept with few sub-grain boundaries inside the grains in UFG pure aluminum, which are similar to the original microstructure before micro-compression. The surface roughness and coordinated deformation ability can be signmicrostructure; micro/meso-forming; ultrafine grains; ECAP; aluminumificantly improved with UFG pure aluminum, which demonstrates that the UFG materials have a strong potential application in micro/meso-forming.

  4. Textural Evolution During Micro Direct Metal Deposition of NiTi Alloy

    NASA Astrophysics Data System (ADS)

    Khademzadeh, Saeed; Bariani, Paolo F.; Bruschi, Stefania

    2018-03-01

    In this research, a micro direct metal deposition process, newly developed as a potential method for micro additive manufacturing was used to fabricate NiTi builds. The effect of scanning strategy on grain growth and textural evolution was investigated using scanning electron microscope equipped with electron backscattered diffraction detector. Investigations showed that, the angle between the successive single tracks has an important role in grain size distribution and textural evolution of NiTi phase. Unidirectional laser beam scanning pattern developed a fiber texture; conversely, a backward and forward scanning pattern developed a strong < {100} > ‖‖ RD texture on the surface of NiTi cubic samples produced by micro direct metal deposition.

  5. Textural Evolution During Micro Direct Metal Deposition of NiTi Alloy

    NASA Astrophysics Data System (ADS)

    Khademzadeh, Saeed; Bariani, Paolo F.; Bruschi, Stefania

    2018-07-01

    In this research, a micro direct metal deposition process, newly developed as a potential method for micro additive manufacturing was used to fabricate NiTi builds. The effect of scanning strategy on grain growth and textural evolution was investigated using scanning electron microscope equipped with electron backscattered diffraction detector. Investigations showed that, the angle between the successive single tracks has an important role in grain size distribution and textural evolution of NiTi phase. Unidirectional laser beam scanning pattern developed a fiber texture; conversely, a backward and forward scanning pattern developed a strong < {100} > ‖‖ RD texture on the surface of NiTi cubic samples produced by micro direct metal deposition.

  6. 14 CFR 300.3 - Reporting of communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Electronic copies of written communications and oral summaries shall be posted to the DOT's electronic docket... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Reporting of communications. 300.3 Section... of communications. (a) General. The following types of substantive communication shall be reported as...

  7. 75 FR 80068 - Renewal of Approved Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ...-0168 in your correspondence. Before including your address, phone number, e-mail address, or other..., or by electronic mail at [email protected] . Please provide a copy of your comments to the BLM via mail, fax, or electronic mail. Mail: Bureau Information Collection Clearance Officer (WO-630...

  8. 47 CFR 63.20 - Electronic filing, copies required; fees; and filing periods for international service providers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... homepage. For information on electronic filing requirements, see part 1, §§ 1.1000 through 1.10018 of this chapter and the IBFS homepage at http://www.fcc.gov/ibfs. Each application shall be accompanied by the fee...

  9. A comparison of manual and electronic counting for total nucleated cell counts on synovial fluid from canine stifle joints.

    PubMed

    Atilola, M A; Lumsden, J H; Rooke, F

    1986-04-01

    Synovial fluids collected from the stifle joints of 20 physically normal adult dogs were subjected to cytological examination. A total nucleated cell count was performed on each sample using both an electronic cell counter and a hemocytometer. The mean of the total counts done with the electronic counter was significantly higher (1008 cells/microL) than that obtained manually with the hemocytometer (848 cells/microL).

  10. Copper vertical micro dendrite fin arrays and their superior boiling heat transfer capability

    NASA Astrophysics Data System (ADS)

    Wang, Ya-Qiao; Lyu, Shu-Shen; Luo, Jia-Li; Luo, Zhi-Yong; Fu, Yuan-Xiang; Heng, Yi; Zhang, Jian-Hui; Mo, Dong-Chuan

    2017-11-01

    Micro pin fin arrays have been widely used in electronic cooling, micro reactors, catalyst support, and wettability modification and so on, and a facile way to produce better micro pin fin arrays is demanded. Herein, a simple electrochemical method has been developed to fabricate copper vertical micro dendrite fin arrays (Cu-VMDFA) with controllable shapes, number density and height. High copper sulphate concentration is one key point to make the dendrite stand vertically. Besides, the applied current should rise at an appropriate rate to ensure the copper dendrite can grow vertically on its own. The Cu-VMDFA can significantly enhance the heat transfer coefficient by approximately twice compared to the plain copper surface. The Cu-VMDFA may be widely used in boiling heat transfer areas such as nuclear power plants, electronic cooling, heat exchangers, and so on.

  11. Electron Spin Dephasing and Decoherence by Interaction with Nuclear Spins in Self-Assembled Quantum Dots

    NASA Technical Reports Server (NTRS)

    Lee, Seungwon; vonAllmen, Paul; Oyafuso, Fabiano; Klimeck, Gerhard; Whale, K. Birgitta

    2004-01-01

    Electron spin dephasing and decoherence by its interaction with nuclear spins in self-assembled quantum dots are investigated in the framework of the empirical tight-binding model. Electron spin dephasing in an ensemble of dots is induced by the inhomogeneous precession frequencies of the electron among dots, while electron spin decoherence in a single dot arises from the inhomogeneous precession frequencies of nuclear spins in the dot. For In(x)Ga(1-x) As self-assembled dots containing 30000 nuclei, the dephasing and decoherence times are predicted to be on the order of 100 ps and 1 (micro)s.

  12. Advanced Sensor and Packaging Technologies for Intelligent Adaptive Engine Controls (Preprint)

    DTIC Science & Technology

    2013-05-01

    combination of micro-electromechanical systems (MEMS) sensor technology, novel ceramic materials, high - temperature electronics, and advanced harsh...with simultaneous pressure measurements up to 1,000 psi. The combination of a high - temperature , high -pressure-ratio compressor system, and adaptive...combination of micro-electromechanical systems (MEMS) sensor technology, novel ceramic materials, high temperature electronics, and advanced harsh

  13. Effect of nano-scale morphology on micro-channel wall surface and electrical characterization in lead silicate glass micro-channel plate

    NASA Astrophysics Data System (ADS)

    Cai, Hua; Li, Fangjun; Xu, Yanglei; Bo, Tiezhu; Zhou, Dongzhan; Lian, Jiao; Li, Qing; Cao, Zhenbo; Xu, Tao; Wang, Caili; Liu, Hui; Li, Guoen; Jia, Jinsheng

    2017-10-01

    Micro-channel plate (MCP) is a two dimensional arrays of microscopic channel charge particle multiplier. Silicate composition and hydrogen reduction are keys to determine surface morphology of micro-channel wall in MCP. In this paper, lead silicate glass micro-channel plates in two different cesium contents (0at%, 0.5at%) and two different hydrogen reduction temperatures (400°C,450°C) were present. The nano-scale morphology, elements content and chemical states of microporous wall surface treated under different alkaline compositions and reduction conditions was investigated by Atomic Force Microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS), respectively. Meanwhile, the electrical characterizations of MCP, including the bulk resistance, electron gain and the density of dark current, were measured in a Vacuum Photoelectron Imaging Test Facility (VPIT).The results indicated that the granular phase occurred on the surface of microporous wall and diffuses in bulk glass is an aggregate of Pb atom derived from the reduction of Pb2+. In micro-channel plate, the electron gain and bulk resistance were mainly correlated to particle size and distribution, the density of dark current (DDC) went up with the increasing root-mean-square roughness (RMS) on the microporous wall surface. Adding cesiums improved the size of Pb atomic aggregation, lowered the relative concentration of [Pb] reduced from Pb2+ and decreased the total roughness of micro-channel wall surface, leading a higher bulk resistance, a lower electron gain and a less dark current. Increasing hydrogen reduction temperature also improved the size of Pb atomic aggregation, but enhanced the relative concentration of [Pb] and enlarged the total roughness of micro-channel wall surface, leading a higher bulk resistance, a lower electron gain and a larger dark current. The reasons for the difference of electrical characteristics were discussed.

  14. Study on the steady operating state of a micro-pulse electron gun.

    PubMed

    Kui, Zhou; Xiangyang, Lu; Shengwen, Quan; Jifei, Zhao; Xing, Luo; Ziqin, Yang

    2014-09-01

    Micro-pulse electron gun (MPG) employs the basic concept of multipacting to produce high-current and short-pulse electron beams from a radio-frequency (RF) cavity. The concept of MPG has been proposed for more than two decades. However, the unstable operating state of MPG vastly obstructs its practical applications. This paper presents a study on the steady operating state of a micro-pulse electron gun with theory and experiments. The requirements for the steady operating state are proposed through the analysis of the interaction between the RF cavity and the beam load. Accordingly, a MPG cavity with the frequency of 2856 MHz has been designed, constructed, and tested. Some primary experiments have been finished. Both the unstable and stable operating states of the MPG have been observed. The stable output beam current has been detected at about 3.8 mA. Further experimental study is under way now.

  15. 49 CFR 171.16 - Detailed hazardous materials incident reports.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... quantity of hazardous waste; (3) A specification cargo tank with a capacity of 1,000 gallons or greater..., DC 20590-0001, or an electronic Hazardous Material Incident Report to the Information System Manager..., submit a written or electronic copy of the Hazardous Materials Incident Report to the FAA Security Field...

  16. 10 CFR 2.1004 - Amendments and additions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... for the Issuance of Licenses for the Receipt of High-Level Radioactive Waste at a Geologic Repository... electronic form must be identified in an electronic notice and made available for inspection and copying by... Pre-License Application Presiding Officer or the Presiding Officer designated for the high-level waste...

  17. 10 CFR 2.1019 - Depositions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Applicable to Proceedings for the Issuance of Licenses for the Receipt of High-Level Radioactive Waste at a... the failure to sign, and shall promptly transmit an electronic copy of the deposition to the Secretary of the Commission for entry into the electronic docket. (e) Where the deposition is to be taken on...

  18. 10 CFR 2.1019 - Depositions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Issuance of Licenses for the Receipt of High-Level Radioactive Waste at a Geologic Repository § 2.1019... the failure to sign, and shall promptly transmit an electronic copy of the deposition to the Secretary of the Commission for entry into the electronic docket. (e) Where the deposition is to be taken on...

  19. 10 CFR 2.1019 - Depositions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Issuance of Licenses for the Receipt of High-Level Radioactive Waste at a Geologic Repository § 2.1019... the failure to sign, and shall promptly transmit an electronic copy of the deposition to the Secretary of the Commission for entry into the electronic docket. (e) Where the deposition is to be taken on...

  20. 49 CFR 171.16 - Detailed hazardous materials incident reports.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... quantity of hazardous waste; (3) A specification cargo tank with a capacity of 1,000 gallons or greater..., DC 20590-0001, or an electronic Hazardous Material Incident Report to the Information System Manager..., submit a written or electronic copy of the Hazardous Materials Incident Report to the FAA Security Field...

  1. 49 CFR 171.16 - Detailed hazardous materials incident reports.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... quantity of hazardous waste; (3) A specification cargo tank with a capacity of 1,000 gallons or greater..., DC 20590-0001, or an electronic Hazardous Material Incident Report to the Information System Manager..., submit a written or electronic copy of the Hazardous Materials Incident Report to the FAA Security Field...

  2. 10 CFR 2.1004 - Amendments and additions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for the Issuance of Licenses for the Receipt of High-Level Radioactive Waste at a Geologic Repository... electronic form must be identified in an electronic notice and made available for inspection and copying by... Pre-License Application Presiding Officer or the Presiding Officer designated for the high-level waste...

  3. 4 CFR 201.3 - Publicly available documents and electronic reading room.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Publicly available documents and electronic reading room. 201.3 Section 201.3 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND... Board. (5) Biographical information about the Chairman and other Board members. (6) Copies of records...

  4. 78 FR 38070 - Renewal of Approved Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... information from individuals and entities seeking authorization for free use of mineral or vegetative... Information and Regulatory Affairs, fax 202-395-5806, or by electronic mail at [email protected] . Please provide a copy of your comments to the BLM. You may do so via mail, fax, or electronic mail. Mail...

  5. Electric Composition Cost Comparison.

    ERIC Educational Resources Information Center

    Joint Committee on Printing, Washington, DC.

    Experience of the U.S. Government Printing Office and others has shown that electronic composition of computer processed data is more economical than printing from camera copy produced by the line printers of digital computers. But electronic composition of data not already being processed by computer is not necessarily economical. This analysis…

  6. 14 CFR 302.3 - Filing of documents.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... in Washington, DC. Documents may be filed either on paper or by electronic means using the process set at the DOT Dockets Management System (DMS) internet website. (2) Such documents will be deemed to... below the space provided for signature. Electronic filers need only submit one copy of the document...

  7. 14 CFR 302.3 - Filing of documents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... in Washington, DC. Documents may be filed either on paper or by electronic means using the process set at the DOT Dockets Management System (DMS) internet website. (2) Such documents will be deemed to... below the space provided for signature. Electronic filers need only submit one copy of the document...

  8. 5 CFR 850.303 - Return of personal documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATIONS (CONTINUED) ELECTRONIC RETIREMENT PROCESSING Records § 850.303 Return of personal documents. An..., OPM may provide the individual with a copy of the document that is derived from electronic records. ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Return of personal documents. 850.303...

  9. 14 CFR 302.3 - Filing of documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... in Washington, DC. Documents may be filed either on paper or by electronic means using the process set at the DOT Dockets Management System (DMS) internet website. (2) Such documents will be deemed to... below the space provided for signature. Electronic filers need only submit one copy of the document...

  10. 14 CFR 302.3 - Filing of documents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... in Washington, DC. Documents may be filed either on paper or by electronic means using the process set at the DOT Dockets Management System (DMS) internet website. (2) Such documents will be deemed to... below the space provided for signature. Electronic filers need only submit one copy of the document...

  11. The New Publishing: Technology's Impact on the Publishing Industry over the Next Decade.

    ERIC Educational Resources Information Center

    Rawlins, Gregory J. E.

    1992-01-01

    Discusses technology's impact on the products, revenue sources, and distribution channels of the publishing industry over the next decade. Highlights include electronic books and copy protection; copyright; advantages of electronic books to users, libraries, and publishers; retailing schemes; changes in education; subscription publishing;…

  12. 75 FR 1757 - Office of Special Education and Rehabilitative Services (OSERS); Overview Information; National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... as artificial intelligence or information technology devices, software, and systems. For more... in an accessible format (e.g., braille, large print, audiotape, or computer diskette) by contacting... electronic application, you may wish to print a copy of it for your records. After you electronically submit...

  13. 48 CFR 4.502 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATTERS Electronic Commerce in Contracting 4.502 Policy. (a) The Federal Government shall use electronic commerce whenever practicable or cost-effective. The use of terms commonly associated with paper transactions (e.g., “copy,” “document,” “page,” “printed,” “sealed envelope,” and “stamped”) shall not be...

  14. Electronic Portfolios.

    ERIC Educational Resources Information Center

    Purves, Alan C.

    1996-01-01

    Outlines three forms of electronic portfolio based on a student's work, a class project about a specific topic, and a class seminar on a broad topic. Discusses logistical problems of management, access, and cross-referencing; technical problems of input, access, and copying; and theoretical issues of the lack of realia, of ownership and copyright,…

  15. Flexible probe for measuring local conductivity variations in Li-ion electrode films

    NASA Astrophysics Data System (ADS)

    Hardy, Emilee; Clement, Derek; Vogel, John; Wheeler, Dean; Mazzeo, Brian

    2018-04-01

    Li-ion battery performance is governed by electronic and ionic properties of the battery. A key metric that characterizes Li-ion battery cell performance is the electronic conductivity of the electrodes, which are metal foils with thin coatings of electrochemically active materials. To accurately measure the spatial variation of electronic conductivity of these electrodes, a micro-four-line probe (μ4LP) was designed and used to non-destructively measure the properties of commercial-quality Li-ion battery films. This previous research established that the electronic conductivity of film electrodes is not homogeneous throughout the entirety of the deposited film area. In this work, a micro-N-line probe (μNLP) and a flexible micro-flex-line probe (μFLP) were developed to improve the non-destructive micro-scale conductivity measurements that we can take. These devices were validated by comparing test results to that of the predecessor, the micro-four-line probe (μ4LP), on various commercial-quality Li-ion battery electrodes. Results show that there is significant variation in conductivity on a millimeter and even micrometer length scale through the electrode film. Compared to the μ4LP, the μNLP and μFLP also introduce additional measurement configuration possibilities, while providing a more robust design. Researchers and manufacturers can use these probes to identify heterogeneity in their electrodes during the fabrication process, which will lead to the development of better batteries.

  16. Adult Competency Education Kit. Basic Skills in Speaking, Math, and Reading for Employment. Part P: ACE Competency Based Job Descriptions: #77--Secretary; #78--Keypunch Operator; Assembly Worker Core Job Description; #82--Electronics Assembler; #83--Printed Circuit Assembler; #84--Micro Electronics Assembler; #85--Chassis Assembler; #87--Machinist Apprentice.

    ERIC Educational Resources Information Center

    San Mateo County Office of Education, Redwood City, CA. Career Preparation Centers.

    This thirteenth of fifteen sets of Adult Competency Education (ACE) Competency Based Job Descriptions in the ACE kit contains job descriptions for Secretary, Keypunch Operator, Electronics Assembler, Printed Circuit Assembler, Micro Electronincs Assembler, Chassis Assembler, and Machinist Apprentice. Each begins with a fact sheet that includes…

  17. An Alu-based, MGB Eclipse real-time PCR method for quantitation of human DNA in forensic samples.

    PubMed

    Nicklas, Janice A; Buel, Eric

    2005-09-01

    The forensic community needs quick, reliable methods to quantitate human DNA in crime scene samples to replace the laborious and imprecise slot blot method. A real-time PCR based method has the possibility of allowing development of a faster and more quantitative assay. Alu sequences are primate-specific and are found in many copies in the human genome, making these sequences an excellent target or marker for human DNA. This paper describes the development of a real-time Alu sequence-based assay using MGB Eclipse primers and probes. The advantages of this assay are simplicity, speed, less hands-on-time and automated quantitation, as well as a large dynamic range (128 ng/microL to 0.5 pg/microL).

  18. Graphene-based in-plane micro-supercapacitors with high power and energy densities

    PubMed Central

    Wu, Zhong–Shuai; Parvez, Khaled; Feng, Xinliang; Müllen, Klaus

    2013-01-01

    Micro-supercapacitors are important on-chip micro-power sources for miniaturized electronic devices. Although the performance of micro-supercapacitors has been significantly advanced by fabricating nanostructured materials, developing thin-film manufacture technologies and device architectures, their power or energy densities remain far from those of electrolytic capacitors or lithium thin-film batteries. Here we demonstrate graphene-based in-plane interdigital micro-supercapacitors on arbitrary substrates. The resulting micro-supercapacitors deliver an area capacitance of 80.7 μF cm−2 and a stack capacitance of 17.9 F cm−3. Further, they show a power density of 495 W cm−3 that is higher than electrolytic capacitors, and an energy density of 2.5 mWh cm−3 that is comparable to lithium thin-film batteries, in association with superior cycling stability. Such microdevices allow for operations at ultrahigh rate up to 1,000 V s−1, three orders of magnitude higher than that of conventional supercapacitors. Micro-supercapacitors with an in-plane geometry have great promise for numerous miniaturized or flexible electronic applications. PMID:24042088

  19. Graphene-based in-plane micro-supercapacitors with high power and energy densities.

    PubMed

    Wu, Zhong-Shuai; Parvez, Khaled; Feng, Xinliang; Müllen, Klaus

    2013-01-01

    Micro-supercapacitors are important on-chip micro-power sources for miniaturized electronic devices. Although the performance of micro-supercapacitors has been significantly advanced by fabricating nanostructured materials, developing thin-film manufacture technologies and device architectures, their power or energy densities remain far from those of electrolytic capacitors or lithium thin-film batteries. Here we demonstrate graphene-based in-plane interdigital micro-supercapacitors on arbitrary substrates. The resulting micro-supercapacitors deliver an area capacitance of 80.7 μF cm⁻² and a stack capacitance of 17.9 F cm⁻³. Further, they show a power density of 495 W cm⁻³ that is higher than electrolytic capacitors, and an energy density of 2.5 mWh cm⁻³ that is comparable to lithium thin-film batteries, in association with superior cycling stability. Such microdevices allow for operations at ultrahigh rate up to 1,000 V s⁻¹, three orders of magnitude higher than that of conventional supercapacitors. Micro-supercapacitors with an in-plane geometry have great promise for numerous miniaturized or flexible electronic applications.

  20. 26 CFR 1.401(a)-21 - Rules relating to the use of an electronic medium to provide applicable notices and to make...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... electronic system must be designed to alert the recipient, at the time an applicable notice is provided, to... electronic delivery of an applicable notice on a prospective basis at any time and explains the procedures... recipient has the effective ability to access. (3) Free paper copy of applicable notice. At the time the...

  1. 26 CFR 1.401(a)-21 - Rules relating to the use of an electronic medium to provide applicable notices and to make...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... electronic system must be designed to alert the recipient, at the time an applicable notice is provided, to... electronic delivery of an applicable notice on a prospective basis at any time and explains the procedures... recipient has the effective ability to access. (3) Free paper copy of applicable notice. At the time the...

  2. 26 CFR 1.401(a)-21 - Rules relating to the use of an electronic medium to provide applicable notices and to make...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... electronic system must be designed to alert the recipient, at the time an applicable notice is provided, to... electronic delivery of an applicable notice on a prospective basis at any time and explains the procedures... recipient has the effective ability to access. (3) Free paper copy of applicable notice. At the time the...

  3. 26 CFR 1.401(a)-21 - Rules relating to the use of an electronic medium to provide applicable notices and to make...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... electronic system must be designed to alert the recipient, at the time an applicable notice is provided, to... electronic delivery of an applicable notice on a prospective basis at any time and explains the procedures... recipient has the effective ability to access. (3) Free paper copy of applicable notice. At the time the...

  4. Scalable fabrication of high-power graphene micro-supercapacitors for flexible and on-chip energy storage

    NASA Astrophysics Data System (ADS)

    El-Kady, Maher F.; Kaner, Richard B.

    2013-02-01

    The rapid development of miniaturized electronic devices has increased the demand for compact on-chip energy storage. Microscale supercapacitors have great potential to complement or replace batteries and electrolytic capacitors in a variety of applications. However, conventional micro-fabrication techniques have proven to be cumbersome in building cost-effective micro-devices, thus limiting their widespread application. Here we demonstrate a scalable fabrication of graphene micro-supercapacitors over large areas by direct laser writing on graphite oxide films using a standard LightScribe DVD burner. More than 100 micro-supercapacitors can be produced on a single disc in 30 min or less. The devices are built on flexible substrates for flexible electronics and on-chip uses that can be integrated with MEMS or CMOS in a single chip. Remarkably, miniaturizing the devices to the microscale results in enhanced charge-storage capacity and rate capability. These micro-supercapacitors demonstrate a power density of ~200 W cm-3, which is among the highest values achieved for any supercapacitor.

  5. Design of Architectures and Materials in In-Plane Micro-supercapacitors: Current Status and Future Challenges.

    PubMed

    Qi, Dianpeng; Liu, Yan; Liu, Zhiyuan; Zhang, Li; Chen, Xiaodong

    2017-02-01

    The rapid development of integrated electronics and the boom in miniaturized and portable devices have increased the demand for miniaturized and on-chip energy storage units. Currently thin-film batteries or microsized batteries are commercially available for miniaturized devices. However, they still suffer from several limitations, such as short lifetime, low power density, and complex architecture, which limit their integration. Supercapacitors can surmount all these limitations. Particularly for micro-supercapacitors with planar architectures, due to their unique design of the in-plane electrode finger arrays, they possess the merits of easy fabrication and integration into on-chip miniaturized electronics. Here, the focus is on the different strategies to design electrode finger arrays and the material engineering of in-plane micro-supercapacitors. It is expected that the advances in micro-supercapacitors with in-plane architectures will offer new opportunities for the miniaturization and integration of energy-storage units for portable devices and on-chip electronics. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. [Isolation and identification of electrochemically active microorganism from micro-aerobic environment].

    PubMed

    Wu, Song; Xiao, Yong; Zheng, Zhi-Yong; Zheng, Yue; Yang, Zhao-Hui; Zhao, Feng

    2014-10-01

    Extracellular electron transfer of electrochemically active microorganism plays vital role in biogeochemical cycling of metals and carbon and in biosynthesis of bioenergy. Compared to anaerobic anode, micro-aerobic anode captures more energy from microbial fuel cell. However, most of previous researches focused on functioning bacteria in anaerobic anode, functioning bacteria in micro-aerobic anode was rarely studied. Herein, we used the traditional aerobic screening technology to isolate functioning bacteria from a micro-aerobic anode. Three pure cultures Aeromonas sp. WS-XY2, Citrobacter sp. WS-XY3 and Bacterium strain WS-XY4 were obtained. WS-XY2 and WS-XY3 were belonged to Proteobacteria, whereas WS-XY4 was possibly a new species. Cyclic voltammetry and chronoamperometry analysis demonstrated all of them showed the electrochemical activity by direct extracellular electron transfer, and micro-aerobic anode could select bacteria that have similar electrochemical activity to proliferate on the anode. We further conclude that functioning bacteria in micro-aerobic anode are more efficient than that of anaerobic anode may be the reason that micro-aerobic anode has better performance than anaerobic anode. Therefore, a thorough study of functioning bacteria in micro-aerobic anode will significantly promote the energy recovery from microbial fuel cell.

  7. Direct laser-patterned micro-supercapacitors from paintable MoS2 films.

    PubMed

    Cao, Liujun; Yang, Shubin; Gao, Wei; Liu, Zheng; Gong, Yongji; Ma, Lulu; Shi, Gang; Lei, Sidong; Zhang, Yunhuai; Zhang, Shengtao; Vajtai, Robert; Ajayan, Pulickel M

    2013-09-09

    Micrometer-sized electrochemical capacitors have recently attracted attention due to their possible applications in micro-electronic devices. Here, a new approach to large-scale fabrication of high-capacitance, two-dimensional MoS2 film-based micro-supercapacitors is demonstrated via simple and low-cost spray painting of MoS2 nanosheets on Si/SiO2 chip and subsequent laser patterning. The obtained micro-supercapacitors are well defined by ten interdigitated electrodes (five electrodes per polarity) with 4.5 mm length, 820 μm wide for each electrode, 200 μm spacing between two electrodes and the thickness of electrode is ∼0.45 μm. The optimum MoS2 -based micro-supercapacitor exhibits excellent electrochemical performance for energy storage with aqueous electrolytes, with a high area capacitance of 8 mF cm(-2) (volumetric capacitance of 178 F cm(-3) ) and excellent cyclic performance, superior to reported graphene-based micro-supercapacitors. This strategy could provide a good opportunity to develop various micro-/nanosized energy storage devices to satisfy the requirements of portable, flexible, and transparent micro-electronic devices. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Cancer Genomics: Integrative and Scalable Solutions in R / Bioconductor | Informatics Technology for Cancer Research (ITCR)

    Cancer.gov

    This proposal develops scalable R / Bioconductor software infrastructure and data resources to integrate complex, heterogeneous, and large cancer genomic experiments. The falling cost of genomic assays facilitates collection of multiple data types (e.g., gene and transcript expression, structural variation, copy number, methylation, and microRNA data) from a set of clinical specimens. Furthermore, substantial resources are now available from large consortium activities like The Cancer Genome Atlas (TCGA).

  9. The theoretical simulation on electrostatic distribution of 1st proximity region in proximity focusing low-light-level image intensifier

    NASA Astrophysics Data System (ADS)

    Zhang, Liandong; Bai, Xiaofeng; Song, De; Fu, Shencheng; Li, Ye; Duanmu, Qingduo

    2015-03-01

    Low-light-level night vision technology is magnifying low light level signal large enough to be seen by naked eye, which uses the photons - photoelectron as information carrier. Until the micro-channel plate was invented, it has been possibility for the realization of high performance and miniaturization of low-light-level night vision device. The device is double-proximity focusing low-light-level image intensifier which places a micro-channel plate close to photocathode and phosphor screen. The advantages of proximity focusing low-light-level night vision are small size, light weight, small power consumption, no distortion, fast response speed, wide dynamic range and so on. It is placed parallel to each other for Micro-channel plate (both sides of it with metal electrode), the photocathode and the phosphor screen are placed parallel to each other. The voltage is applied between photocathode and the input of micro-channel plate when image intensifier works. The emission electron excited by photo on the photocathode move towards to micro-channel plate under the electric field in 1st proximity focusing region, and then it is multiplied through the micro-channel. The movement locus of emission electrons can be calculated and simulated when the distributions of electrostatic field equipotential lines are determined in the 1st proximity focusing region. Furthermore the resolution of image tube can be determined. However the distributions of electrostatic fields and equipotential lines are complex due to a lot of micro-channel existing in the micro channel plate. This paper simulates electrostatic distribution of 1st proximity region in double-proximity focusing low-light-level image intensifier with the finite element simulation analysis software Ansoft maxwell 3D. The electrostatic field distributions of 1st proximity region are compared when the micro-channel plates' pore size, spacing and inclination angle ranged. We believe that the electron beam movement trajectory in 1st proximity region will be better simulated when the electronic electrostatic fields are simulated.

  10. Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

    NASA Astrophysics Data System (ADS)

    Acciarri, R.; Adams, C.; An, R.; Anthony, J.; Asaadi, J.; Auger, M.; Bagby, L.; Balasubramanian, S.; Baller, B.; Barnes, C.; Barr, G.; Bass, M.; Bay, F.; Bishai, M.; Blake, A.; Bolton, T.; Bullard, B.; Camilleri, L.; Caratelli, D.; Carls, B.; Castillo Fernandez, R.; Cavanna, F.; Chen, H.; Church, E.; Cianci, D.; Cohen, E.; Collin, G. H.; Conrad, J. M.; Convery, M.; Crespo-Anadón, J. I.; De Geronimo, G.; Del Tutto, M.; Devitt, D.; Dytman, S.; Eberly, B.; Ereditato, A.; Escudero Sanchez, L.; Esquivel, J.; Fadeeva, A. A.; Fleming, B. T.; Foreman, W.; Furmanski, A. P.; Garcia-Gamez, D.; Garvey, G. T.; Genty, V.; Goeldi, D.; Gollapinni, S.; Graf, N.; Gramellini, E.; Greenlee, H.; Grosso, R.; Guenette, R.; Hackenburg, A.; Hamilton, P.; Hen, O.; Hewes, J.; Hill, C.; Ho, J.; Horton-Smith, G.; Hourlier, A.; Huang, E.-C.; James, C.; de Vries, J. Jan; Jen, C.-M.; Jiang, L.; Johnson, R. A.; Joshi, J.; Jostlein, H.; Kaleko, D.; Karagiorgi, G.; Ketchum, W.; Kirby, B.; Kirby, M.; Kobilarcik, T.; Kreslo, I.; Laube, A.; Li, S.; Li, Y.; Lister, A.; Littlejohn, B. R.; Lockwitz, S.; Lorca, D.; Louis, W. C.; Luethi, M.; Lundberg, B.; Luo, X.; Marchionni, A.; Mariani, C.; Marshall, J.; Martinez Caicedo, D. A.; Meddage, V.; Miceli, T.; Mills, G. B.; Moon, J.; Mooney, M.; Moore, C. D.; Mousseau, J.; Murrells, R.; Naples, D.; Nienaber, P.; Nowak, J.; Palamara, O.; Paolone, V.; Papavassiliou, V.; Pate, S. F.; Pavlovic, Z.; Piasetzky, E.; Porzio, D.; Pulliam, G.; Qian, X.; Raaf, J. L.; Radeka, V.; Rafique, A.; Rescia, S.; Rochester, L.; von Rohr, C. Rudolf; Russell, B.; Schmitz, D. W.; Schukraft, A.; Seligman, W.; Shaevitz, M. H.; Sinclair, J.; Smith, A.; Snider, E. L.; Soderberg, M.; Söldner-Rembold, S.; Soleti, S. R.; Spentzouris, P.; Spitz, J.; St. John, J.; Strauss, T.; Szelc, A. M.; Tagg, N.; Terao, K.; Thomson, M.; Thorn, C.; Toups, M.; Tsai, Y.-T.; Tufanli, S.; Usher, T.; Van De Pontseele, W.; Van de Water, R. G.; Viren, B.; Weber, M.; Wickremasinghe, D. A.; Wolbers, S.; Wongjirad, T.; Woodruff, K.; Yang, T.; Yates, L.; Yu, B.; Zeller, G. P.; Zennamo, J.; Zhang, C.

    2017-08-01

    The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outside the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. This noise level is significantly lower than previous experiments utilizing warm front-end electronics.

  11. Electron microscopic evaluation of a gold glaucoma micro shunt after explantation.

    PubMed

    Berk, Thomas A; Tam, Diamond Y; Werner, Liliana; Mamalis, Nick; Ahmed, Iqbal Ike K

    2015-03-01

    We present a case of an explanted gold glaucoma micro shunt (GMS Plus) and the subsequent light and electron microscopic analyses. The shunt was implanted in a patient with medically refractive glaucoma. The intraocular pressure (IOP) was stable at 12 mm Hg 6 months postoperatively but spiked to 26 mm Hg 6 months later; membranous growth was visible on the implant gonioscopically. A second gold micro shunt was placed 2 years after the first. The IOP was 7 mm Hg 1 week postoperatively but increased to 23 mm Hg 3 weeks later; similar membranous growth was visible on this implant. One of the shunts was explanted, and light and scanning electron microscopic analyses revealed encapsulation around the shunt exterior and connective tissue invasion of the microstructure. This represents the first electron microscopic analysis of an explanted gold glaucoma micro shunt and the first unequivocal images of the fibrotic pseudo-capsule traversing its microchannels and fenestrations. Dr. Ahmed is a consultant to and has received research grants from Solx, Inc. No other author has a financial or proprietary interest in any material or method mentioned. Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  12. SU-F-T-68: Characterizes of Microdetectors in Electron Beam Dosimetry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Das, I; Andersen, A; Akino, Y

    Purpose: Electron beam dosimetry requires high resolution data due to finite range that can be accomplished with small volume detectors. The small-field used in advance technologies in photon beam has created a market for microdetectors, however characteristics are significantly variable in photon beams and relatively unknown in electron beam that is investigated in this study. Methods: Among nearly 2 dozen microdetectors that have been investigated in small fields of photon beam, two popular detectors (microDiamond 60019 (PTW)) and W1 plastic scintillator detector (Standard Imaging)) that are tissue equivalent and have very small sensitive volume are selected. Electron beams from Varianmore » linear accelerators were used to investigate dose linearity dose rate dependence, energy dependence, depth dose and profiles in a reference condition in a water phantom. For W1 that has its own Supermax electrometer point by point measurements were performed. For microDiamond, a PTW-scanning tank was used for both scanning and point dose measurements. Results: W1 detector showed excellent dose linearity (r{sup 2} =1.0) from 5–500 MU either with variation of dose rate or beam energy. Similar findings were also observed for microdiamond with r{sup 2}=1.0. Percent variations in dose/MU for W1 and microDiamond were 0.2–1.1% and 0.4–1.2%, respectively among dose rate and beam energy. This variation was random for microDiamond, whereas it decreased with beam energy and dose rate for W1. The depth dose and profiles were within ±1 mm for both detectors. Both detectors did not show any energy dependence in electron beams. Conclusion: Both microDiamond and W1 detectors provided superior characteristics of beam parameters in electron beam including dose, dose rate linearity and energy independence. Both can be used in electron beam except W1 require point by point measurements and microdiamond requires 1500 MU for initial quenching.« less

  13. Ionization Electron Signal Processing in Single Phase LArTPCs II. Data/Simulation Comparison and Performance in MicroBooNE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, C.; et al.

    The single-phase liquid argon time projection chamber (LArTPC) provides a large amount of detailed information in the form of fine-grained drifted ionization charge from particle traces. To fully utilize this information, the deposited charge must be accurately extracted from the raw digitized waveforms via a robust signal processing chain. Enabled by the ultra-low noise levels associated with cryogenic electronics in the MicroBooNE detector, the precise extraction of ionization charge from the induction wire planes in a single-phase LArTPC is qualitatively demonstrated on MicroBooNE data with event display images, and quantitatively demonstrated via waveform-level and track-level metrics. Improved performance of inductionmore » plane calorimetry is demonstrated through the agreement of extracted ionization charge measurements across different wire planes for various event topologies. In addition to the comprehensive waveform-level comparison of data and simulation, a calibration of the cryogenic electronics response is presented and solutions to various MicroBooNE-specific TPC issues are discussed. This work presents an important improvement in LArTPC signal processing, the foundation of reconstruction and therefore physics analyses in MicroBooNE.« less

  14. Cost-Effective Red Water Disposal by Electron Beam Radiolysis.

    DTIC Science & Technology

    1994-06-28

    mixed with amonium nitrate to form Amatols, or with aluminum powder to form Tritonal, or with RDX to form Cyclonite, or with Composition B. It is also...Department of’ the Army position, policy, or decision, unless so designated by other documentation. ILPM~ fi 4 vbm. d ) MASTER COPY KEEP THIS COPY FOR...by nitration of toluene, meta-nitrotoluene or ortho-nitrotoluene U with mixed nitric and sulfuric acid in several steps. Insoluble and unwanted

  15. On-chip micro-power: three-dimensional structures for micro-batteries and micro-supercapacitors

    NASA Astrophysics Data System (ADS)

    Beidaghi, Majid; Wang, Chunlei

    2010-04-01

    With the miniaturization of portable electronic devices, there is a demand for micro-power source which can be integrated on the semiconductor chips. Various micro-batteries have been developed in recent years to generate or store the energy that is needed by microsystems. Micro-supercapacitors are also developed recently to couple with microbatteries and energy harvesting microsystems and provide the peak power. Increasing the capacity per footprint area of micro-batteries and micro-supercapacitors is a great challenge. One promising route is the manufacturing of three dimensional (3D) structures for these micro-devices. In this paper, the recent advances in fabrication of 3D structure for micro-batteries and micro-supercapacitors are briefly reviewed.

  16. Michel electron reconstruction using cosmic-ray data from the MicroBooNE LArTPC

    NASA Astrophysics Data System (ADS)

    Acciarri, R.; Adams, C.; An, R.; Anthony, J.; Asaadi, J.; Auger, M.; Bagby, L.; Balasubramanian, S.; Baller, B.; Barnes, C.; Barr, G.; Bass, M.; Bay, F.; Bishai, M.; Blake, A.; Bolton, T.; Bugel, L.; Camilleri, L.; Caratelli, D.; Carls, B.; Castillo Fernandez, R.; Cavanna, F.; Chen, H.; Church, E.; Cianci, D.; Cohen, E.; Collin, G. H.; Conrad, J. M.; Convery, M.; Crespo-Anadón, J. I.; Del Tutto, M.; Devitt, D.; Dytman, S.; Eberly, B.; Ereditato, A.; Escudero Sanchez, L.; Esquivel, J.; Fleming, B. T.; Foreman, W.; Furmanski, A. P.; Garcia-Gamez, D.; Garvey, G. T.; Genty, V.; Goeldi, D.; Gollapinni, S.; Graf, N.; Gramellini, E.; Greenlee, H.; Grosso, R.; Guenette, R.; Hackenburg, A.; Hamilton, P.; Hen, O.; Hewes, J.; Hill, C.; Ho, J.; Horton-Smith, G.; Huang, E.-C.; James, C.; de Vries, J. Jan; Jen, C.-M.; Jiang, L.; Johnson, R. A.; Joshi, J.; Jostlein, H.; Kaleko, D.; Karagiorgi, G.; Ketchum, W.; Kirby, B.; Kirby, M.; Kobilarcik, T.; Kreslo, I.; Laube, A.; Li, Y.; Lister, A.; Littlejohn, B. R.; Lockwitz, S.; Lorca, D.; Louis, W. C.; Luethi, M.; Lundberg, B.; Luo, X.; Marchionni, A.; Mariani, C.; Marshall, J.; Martinez Caicedo, D. A.; Meddage, V.; Miceli, T.; Mills, G. B.; Moon, J.; Mooney, M.; Moore, C. D.; Mousseau, J.; Murrells, R.; Naples, D.; Nienaber, P.; Nowak, J.; Palamara, O.; Paolone, V.; Papavassiliou, V.; Pate, S. F.; Pavlovic, Z.; Piasetzky, E.; Porzio, D.; Pulliam, G.; Qian, X.; Raaf, J. L.; Rafique, A.; Rochester, L.; von Rohr, C. Rudolf; Russell, B.; Schmitz, D. W.; Schukraft, A.; Seligman, W.; Shaevitz, M. H.; Sinclair, J.; Snider, E. L.; Soderberg, M.; Söldner-Rembold, S.; Soleti, S. R.; Spentzouris, P.; Spitz, J.; St. John, J.; Strauss, T.; Sutton, K. A.; Szelc, A. M.; Tagg, N.; Terao, K.; Thomson, M.; Toups, M.; Tsai, Y.-T.; Tufanli, S.; Usher, T.; Van de Water, R. G.; Viren, B.; Weber, M.; Wickremasinghe, D. A.; Wolbers, S.; Wongjirad, T.; Woodruff, K.; Yang, T.; Yates, L.; Zeller, G. P.; Zennamo, J.; Zhang, C.

    2017-09-01

    The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by the decay at rest of cosmic-ray muons. Michel electrons are abundantly produced in the TPC, and given their well known energy spectrum can be used to study MicroBooNE's detector response to low-energy electrons (electrons with energies up to ~ 50 MeV). We describe the fully-automated algorithm developed to reconstruct Michel electrons, with which a sample of ~ 14,000 Michel electron candidates is obtained. Most of this article is dedicated to studying the impact of radiative photons produced by Michel electrons on the accuracy and resolution of their energy measurement. In this energy range, ionization and bremsstrahlung photon production contribute similarly to electron energy loss in argon, leading to a complex electron topology in the TPC. By profiling the performance of the reconstruction algorithm on simulation we show that the ability to identify and include energy deposited by radiative photons leads to a significant improvement in the energy measurement of low-energy electrons. The fractional energy resolution we measure improves from over 30% to ~ 20% when we attempt to include radiative photons in the reconstruction. These studies are relevant to a large number of analyses which aim to study neutrinos by measuring electrons produced by νe interactions over a broad energy range.

  17. Michel Electron Reconstruction Using Cosmic-Ray Data from the MicroBooNE LArTPC

    DOE PAGES

    Acciarri, R.

    2017-09-14

    The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by the decay at rest of cosmic-ray muons. Michel electrons are abundantly produced in the TPC, and given their well known energy spectrum can be used to study MicroBooNE's detector response to low-energy electrons (electrons with energies up to ~50 MeV). We describe the fully-automated algorithm developed to reconstruct Michel electrons, with which a sample of ~14,000 Michel electron candidates is obtained. Most of this article is dedicated to studying the impact of radiative photons produced by Michel electrons on the accuracy and resolution of their energy measurement. In this energy range, ionization and bremsstrahlung photon production contribute similarly to electron energy loss in argon, leading to a complex electron topology in the TPC. By profiling the performance of the reconstruction algorithm on simulation we show that the ability to identify and include energy deposited by radiative photons leads to a significant improvement in the energy measurement of low-energy electrons. The fractional energy resolution we measure improves from over 30% to ~20% when we attempt to include radiative photons in the reconstruction. These studies are relevant to a large number of analyses which aim to study neutrinos by measuring electrons produced bymore » $$\

  18. Gene expression and pharmacology of nematode NLP-12 neuropeptides.

    PubMed

    McVeigh, Paul; Leech, Suzie; Marks, Nikki J; Geary, Timothy G; Maule, Aaron G

    2006-05-31

    This study examines the biology of NLP-12 neuropeptides in Caenorhabditis elegans, and in the parasitic nematodes Ascaris suum and Trichostrongylus colubriformis. DYRPLQFamide (1 nM-10 microM; n > or =6) produced contraction of innervated dorsal and ventral Ascaris body wall muscle preparations (10 microM, 6.8+/-1.9 g; 1 microM, 4.6+/-1.8 g; 0.1 microM, 4.1+/-2.0 g; 10 nM, 3.8+/-2.0 g; n > or =6), and also caused a qualitatively similar, but quantitatively lower contractile response (10 microM, 4.0+/-1.5 g, n=6) on denervated muscle strips. Ovijector muscle displayed no measurable response (10 microM, n=5). nlp-12 cDNAs were characterised from A. suum (As-nlp-12) and T. colubriformis (Tc-nlp-12), both of which show sequence similarity to C. elegans nlp-12, in that they encode multiple copies of -LQFamide peptides. In C. elegans, reverse transcriptase (RT)-PCR analysis showed that nlp-12 was transcribed throughout the life cycle, suggesting that DYRPLQFamide plays a constitutive role in the nervous system of this nematode. Transcription was also identified in both L3 and adult stages of T. colubriformis, in which Tc-nlp-12 is expressed in a single tail neurone. Conversely, As-nlp-12 is expressed in both head and tail tissue of adult female A. suum, suggesting species-specific differences in the transcription pattern of this gene.

  19. Fabrication of Smooth Patterned Structures of Refractory Metals, Semiconductors, and Oxides via Template Stripping

    PubMed Central

    2013-01-01

    The template-stripping method can yield smooth patterned films without surface contamination. However, the process is typically limited to coinage metals such as silver and gold because other materials cannot be readily stripped from silicon templates due to strong adhesion. Herein, we report a more general template-stripping method that is applicable to a larger variety of materials, including refractory metals, semiconductors, and oxides. To address the adhesion issue, we introduce a thin gold layer between the template and the deposited materials. After peeling off the combined film from the template, the gold layer can be selectively removed via wet etching to reveal a smooth patterned structure of the desired material. Further, we demonstrate template-stripped multilayer structures that have potential applications for photovoltaics and solar absorbers. An entire patterned device, which can include a transparent conductor, semiconductor absorber, and back contact, can be fabricated. Since our approach can also produce many copies of the patterned structure with high fidelity by reusing the template, a low-cost and high-throughput process in micro- and nanofabrication is provided that is useful for electronics, plasmonics, and nanophotonics. PMID:24001174

  20. 75 FR 25869 - The National Institutes of Health and the Food and Drug Administration Joint Leadership Council...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... comments to the Division of Dockets Management (HFA- 305), Food and Drug Administration, 5630 Fishers Lane..., an ever-changing economic landscape resulting from globalization, and the prospect for fundamental... Dockets Management (see ADDRESSES) written or electronic comments. Submit a single copy of electronic...

  1. 49 CFR 172.201 - Preparation and retention of shipping papers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... basic description required by § 172.202(a). (5) Electronic shipping papers. For transportation by rail... the shipping paper required by § 172.200(a), or an electronic image thereof, that is accessible at or... hazardous waste, the shipping paper copy must be retained for three years after the material is accepted by...

  2. 77 FR 4000 - Privacy Act of 1974; Altered System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ..., citizenship, proof of relationship, and limited use for genealogical purposes. The first change updates the... the 15 CFR part 50 and in accordance with 13 U.S.C. 8 to provide proof of age, citizenship, proof of... electronic media. Paper copies, digital media, and electronic media that contain sensitive information are...

  3. 78 FR 38872 - Approval and Promulgation of Air Quality Implementation Plans; Idaho Amalgamated Sugar Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... form of encryption, and be free of any defects or viruses. Docket: All documents in the electronic... hard copy form. Publicly available docket materials are available either electronically in www... determination for TASCO's fossil fuel-fired Riley Boiler. This alternative control measure is also referred to...

  4. 77 FR 55171 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Deferral for CO2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... consider your comment. Electronic files should avoid the use of special characters, any form of encryption... copy form. Publicly available docket materials are available either electronically in www.regulations... biologically-based materials other than fossil fuels and mineral sources of carbon. Examples of ``biogenic CO 2...

  5. ELNET--The Electronic Library Database System.

    ERIC Educational Resources Information Center

    King, Shirley V.

    1991-01-01

    ELNET (Electronic Library Network), a Japanese language database, allows searching of index terms and free text terms from articles and stores the full text of the articles on an optical disc system. Users can order fax copies of the text from the optical disc. This article also explains online searching and discusses machine translation. (LRW)

  6. 47 CFR 101.1523 - Sharing and coordination among non-government licensees and between non-government and government...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Wireless Telecommunications Bureau announces by public notice the implementation of a third-party database...) Provide an electronic copy of an interference analysis to the third-party database manager which...-party database managers shall receive and retain the interference analyses electronically and make them...

  7. 47 CFR 101.1523 - Sharing and coordination among non-government licensees and between non-government and government...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Wireless Telecommunications Bureau announces by public notice the implementation of a third-party database...) Provide an electronic copy of an interference analysis to the third-party database manager which...-party database managers shall receive and retain the interference analyses electronically and make them...

  8. 47 CFR 101.1523 - Sharing and coordination among non-government licensees and between non-government and government...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Wireless Telecommunications Bureau announces by public notice the implementation of a third-party database...) Provide an electronic copy of an interference analysis to the third-party database manager which...-party database managers shall receive and retain the interference analyses electronically and make them...

  9. 47 CFR 101.1523 - Sharing and coordination among non-government licensees and between non-government and government...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Wireless Telecommunications Bureau announces by public notice the implementation of a third-party database...) Provide an electronic copy of an interference analysis to the third-party database manager which...-party database managers shall receive and retain the interference analyses electronically and make them...

  10. 47 CFR 101.1523 - Sharing and coordination among non-government licensees and between non-government and government...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Wireless Telecommunications Bureau announces by public notice the implementation of a third-party database...) Provide an electronic copy of an interference analysis to the third-party database manager which...-party database managers shall receive and retain the interference analyses electronically and make them...

  11. 77 FR 61443 - Acceptance of Application for Special Nuclear Materials License From Rensselaer Polytechnic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... determination by the presiding officer that the filing demonstrates good cause by satisfying the following three... on electronic storage media. Participants may not submit paper copies of their filings unless they.... Participants who believe that they have a good cause for not submitting documents electronically must file an...

  12. 77 FR 9998 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... on electronic storage media. Participants may not submit paper copies of their filings unless they... that they have a good cause for not submitting documents electronically must file an exemption request.... Participants are requested not to include personal privacy information, such as social security numbers, home...

  13. 75 FR 13314 - Duke Energy Carolinas, LLC; Notice of Consideration of Issuance of Amendments to Facility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... on electronic storage media. Participants may not submit paper copies of their filings unless they... holidays. Participants who believe that they have a good cause for not submitting documents electronically..., such as social security numbers, home addresses, or home phone numbers in their filings, unless an NRC...

  14. 75 FR 71467 - Exelon Nuclear Texas Holdings, LLC, Early Site Permit Application for the Victoria County Station...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... on electronic storage media. Participants may not submit paper copies of their filings unless they... have a good cause for not submitting documents electronically must file an exemption request, in.... Participants are requested not to include personal privacy information, such as social security numbers, home...

  15. 49 CFR 1104.1 - Address, identification, and electronic filing option.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 2 of 4” and so forth). (e) Persons filing pleadings and documents with the Board have the option of electronically filing (e-filing) certain types of pleadings and documents instead of filing paper copies. Details regarding the types of pleadings and documents eligible for e-filing, the procedures to be followed, and...

  16. 9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    PubMed Central

    Dodonova, Svetlana O; Aderhold, Patrick; Kopp, Juergen; Ganeva, Iva; Röhling, Simone; Hagen, Wim J H; Sinning, Irmgard; Wieland, Felix; Briggs, John A G

    2017-01-01

    COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane, triggering polymerization and budding. The vesicle uncoats before fusion with a target membrane. Coat components are structurally conserved between COPI and clathrin/adaptor proteins. Using cryo-electron tomography and subtomogram averaging, we determined the structure of the COPI coat assembled on membranes in vitro at 9 Å resolution. We also obtained a 2.57 Å resolution crystal structure of βδ-COP. By combining these structures we built a molecular model of the coat. We additionally determined the coat structure in the presence of ArfGAP proteins that regulate coat dissociation. We found that Arf1 occupies contrasting molecular environments within the coat, leading us to hypothesize that some Arf1 molecules may regulate vesicle assembly while others regulate coat disassembly. DOI: http://dx.doi.org/10.7554/eLife.26691.001 PMID:28621666

  17. Amplification and up-regulation of MIR30D was associated with disease progression of cervical squamous cell carcinomas.

    PubMed

    Zhou, You; Hao, Yinghua; Li, Yuxia; Li, Ruizhen; Wu, Ruifang; Wang, Shubin; Fang, Zhengyu

    2017-03-29

    Cervical squamous cell carcinoma (CSCC) is the most frequent type among cervical cancers. Although the altered miRNA miR-30d expression and the amplified chromosome locus of MIR30D, 8q24, have been reported in somatic cancers, the definitive functional impact of such region especially in CSCC remains under-investigated. One hundred thirty-six cases of CSCC tissues and matched adjacent normal ovarian epithelial tissues were assessed in this study. FISH and qPCR were performed to detect the copy number and microRNA expression of MIR30D gene in the collected samples. In in-vitro study, proliferation of CSCC cells were analyzed using WST-1 assay and invasion abilities of CSCC cells were evaluated by transwell assay. In-vivo study using a model of nude mice bearing tumor was also performed. Copy number gains of MIR30D were detected in 22.8% (31 out of 136) of CSCC samples. Copy number of MIR30D was positively correlated with tumor progression. CSCCs with lymph node metastases (LNM) also showed more frequencies (36.4%) of MIR30D amplification than those without LNM (18.4%, p < 0.05). CSCCs with increased copy number of MIR30D also showed a positive correlation with miR-30d up-regulation. Inhibition of miR-30d in CSCC cells led to impaired tumor growth and migration. Copy number amplifications of MIR30D gene and enhanced expression of miR-30d were positively correlated with tumor progression in CSCCs, indicating miR-30d might play an oncomiric role in the progression of CSCC.

  18. Copy-Number Gains of HUWE1 Due to Replication- and Recombination-Based Rearrangements

    PubMed Central

    Froyen, Guy; Belet, Stefanie; Martinez, Francisco; Santos-Rebouças, Cíntia Barros; Declercq, Matthias; Verbeeck, Jelle; Donckers, Lene; Berland, Siren; Mayo, Sonia; Rosello, Monica; Pimentel, Márcia Mattos Gonçalves; Fintelman-Rodrigues, Natalia; Hovland, Randi; Rodrigues dos Santos, Suely; Raymond, F. Lucy; Bose, Tulika; Corbett, Mark A.; Sheffield, Leslie; van Ravenswaaij-Arts, Conny M.A.; Dijkhuizen, Trijnie; Coutton, Charles; Satre, Veronique; Siu, Victoria; Marynen, Peter

    2012-01-01

    We previously reported on nonrecurrent overlapping duplications at Xp11.22 in individuals with nonsyndromic intellectual disability (ID) harboring HSD17B10, HUWE1, and the microRNAs miR-98 and let-7f-2 in the smallest region of overlap. Here, we describe six additional individuals with nonsyndromic ID and overlapping microduplications that segregate in the families. High-resolution mapping of the 12 copy-number gains reduced the minimal duplicated region to the HUWE1 locus only. Consequently, increased mRNA levels were detected for HUWE1, but not HSD17B10. Marker and SNP analysis, together with identification of two de novo events, suggested a paternally derived intrachromosomal duplication event. In four independent families, we report on a polymorphic 70 kb recurrent copy-number gain, which harbors part of HUWE1 (exon 28 to 3′ untranslated region), including miR-98 and let-7f-2. Our findings thus demonstrate that HUWE1 is the only remaining dosage-sensitive gene associated with the ID phenotype. Junction and in silico analysis of breakpoint regions demonstrated simple microhomology-mediated rearrangements suggestive of replication-based duplication events. Intriguingly, in a single family, the duplication was generated through nonallelic homologous recombination (NAHR) with the use of HUWE1-flanking imperfect low-copy repeats, which drive this infrequent NAHR event. The recurrent partial HUWE1 copy-number gain was also generated through NAHR, but here, the homologous sequences used were identified as TcMAR-Tigger DNA elements, a template that has not yet been reported for NAHR. In summary, we showed that an increased dosage of HUWE1 causes nonsyndromic ID and demonstrated that the Xp11.22 region is prone to recombination- and replication-based rearrangements. PMID:22840365

  19. Dysregulation of serum microRNA-574-3p and its clinical significance in hepatocellular carcinoma.

    PubMed

    Shen, Xianjuan; Xue, Yajing; Cong, Hui; Wang, Xudong; Ju, Shaoqing

    2018-07-01

    Objectives To explore microRNA-574-3p expression in serum of patients with hepatocellular carcinoma and investigate correlations between serum microRNA-574-3p expression and the development and prognosis of hepatocellular carcinoma. Design and methods Serum samples were collected from 70 patients with primary hepatocellular carcinoma, 40 patients with cirrhosis and 45 healthy controls. Serum microRNA-574-3p expression levels were detected by real-time quantitative polymerase chain reaction. The linearity, specificity and reproducibility were evaluated. In addition, the diagnostic value of microRNA-574-3p and its correlations with clinicopathologic features were assessed. Results The relative expression of microRNA-574-3p in hepatocellular carcinoma patients, cirrhosis patients and healthy controls was 2.306 (1.801-3.130), 1.362 (0.994-1.665) and 1.263 (0.765-1.723), respectively, indicating that it was significantly higher in hepatocellular carcinoma patients than that in the other two groups ( U = 439.5, 514.5, both P < 0.0001) and was significantly correlated with hepatitis B virus DNA copies ( U = 383.0, P = 0.018). In hepatitis B virus-positive hepatocellular carcinoma patients, the relative expression of microRNA-574-3p was significantly correlated with hepatitis B virus DNA concentration ( r = 0.348, P = 0.022). Compared with healthy control group, AUC ROC of serum microRNA-574-3p in hepatocellular carcinoma group was 0.837 with 95% CI: 0.763-0.910. Combining microRNA-574-3p, AFU and alpha-fetoprotein together, the sensitivity was highest compared with other markers alone or combined. Conclusions The relative expression of serum microRNA-574-3p in hepatocellular carcinoma patients was significantly higher than that in cirrhosis patients and healthy controls, and it may be an important biomarker in the auxiliary diagnosis of hepatocellular carcinoma.

  20. Study of Electromagnetic Interactions with the MicroBooNE Detector

    NASA Astrophysics Data System (ADS)

    Caratelli, David; MicroBooNE Collaboration

    2017-01-01

    MicroBooNE is an experiment which employs the Liquid Argon Time Projection Chamber (LArTPC) detector technology to study neutrinos produced with the Fermilab Booster Neutrino Beam. As for any accelerator-based detector interested in studying neutrino oscillations, it is essential to be able to identify and reconstruct the kinematic properties of electrons and photons produced in μν and νe interactions. We report current progress in reconstructing electron and photon electromagnetic (EM) showers using data from the MicroBooNE LArTPC. These studies cover EM showers in the tens to hundreds of MeV energy range; they lay the foundation for MicroBooNE's investigation of the excess of low-energy EM events reported by MiniBooNE, and are of interest to the wider LArTPC neutrino community.

  1. Simultaneous determination of chlorinated organic compounds from environmental samples using gas chromatography coupled with a micro electron capture detector and micro-plasma atomic emission detector

    NASA Astrophysics Data System (ADS)

    Quan, Xie; Chen, Shuo; Platzer, Bernhard; Chen, Jingwen; Gfrerer, Marion

    2002-01-01

    Water and sediment samples were screened simultaneously for the presence of polychlorinated organic compounds using gas chromatography (GC) coupled with an micro electron capture detector (μ-ECD) and a newly developed helium plasma based on a micro-atomic emission detector (μ-AED). The GC column effluent was split 15:85 between two detectors. In this way, two chromatograms, one obtained by μ-ECD and another by μ-AED, were recorded simultaneously. α-, β-hexachlorocyclohexane and p, p'-DDE were detected. RSDs of the monitoring results from the two detection methods were <20% for the three compounds. A detection limit of 8.5 pg and at least 3 orders of magnitude of linear range for μ-AED was observed.

  2. Steps to achieve quantitative measurements of microRNA using two step droplet digital PCR.

    PubMed

    Stein, Erica V; Duewer, David L; Farkas, Natalia; Romsos, Erica L; Wang, Lili; Cole, Kenneth D

    2017-01-01

    Droplet digital PCR (ddPCR) is being advocated as a reference method to measure rare genomic targets. It has consistently been proven to be more sensitive and direct at discerning copy numbers of DNA than other quantitative methods. However, one of the largest obstacles to measuring microRNA (miRNA) using ddPCR is that reverse transcription efficiency depends upon the target, meaning small RNA nucleotide composition directly effects primer specificity in a manner that prevents traditional quantitation optimization strategies. Additionally, the use of reagents that are optimized for miRNA measurements using quantitative real-time PCR (qRT-PCR) appear to either cause false positive or false negative detection of certain targets when used with traditional ddPCR quantification methods. False readings are often related to using inadequate enzymes, primers and probes. Given that two-step miRNA quantification using ddPCR relies solely on reverse transcription and uses proprietary reagents previously optimized only for qRT-PCR, these barriers are substantial. Therefore, here we outline essential controls, optimization techniques, and an efficacy model to improve the quality of ddPCR miRNA measurements. We have applied two-step principles used for miRNA qRT-PCR measurements and leveraged the use of synthetic miRNA targets to evaluate ddPCR following cDNA synthesis with four different commercial kits. We have identified inefficiencies and limitations as well as proposed ways to circumvent identified obstacles. Lastly, we show that we can apply these criteria to a model system to confidently quantify miRNA copy number. Our measurement technique is a novel way to quantify specific miRNA copy number in a single sample, without using standard curves for individual experiments. Our methodology can be used for validation and control measurements, as well as a diagnostic technique that allows scientists, technicians, clinicians, and regulators to base miRNA measures on a single unit of measurement rather than a ratio of values.

  3. Steps to achieve quantitative measurements of microRNA using two step droplet digital PCR

    PubMed Central

    Duewer, David L.; Farkas, Natalia; Romsos, Erica L.; Wang, Lili; Cole, Kenneth D.

    2017-01-01

    Droplet digital PCR (ddPCR) is being advocated as a reference method to measure rare genomic targets. It has consistently been proven to be more sensitive and direct at discerning copy numbers of DNA than other quantitative methods. However, one of the largest obstacles to measuring microRNA (miRNA) using ddPCR is that reverse transcription efficiency depends upon the target, meaning small RNA nucleotide composition directly effects primer specificity in a manner that prevents traditional quantitation optimization strategies. Additionally, the use of reagents that are optimized for miRNA measurements using quantitative real-time PCR (qRT-PCR) appear to either cause false positive or false negative detection of certain targets when used with traditional ddPCR quantification methods. False readings are often related to using inadequate enzymes, primers and probes. Given that two-step miRNA quantification using ddPCR relies solely on reverse transcription and uses proprietary reagents previously optimized only for qRT-PCR, these barriers are substantial. Therefore, here we outline essential controls, optimization techniques, and an efficacy model to improve the quality of ddPCR miRNA measurements. We have applied two-step principles used for miRNA qRT-PCR measurements and leveraged the use of synthetic miRNA targets to evaluate ddPCR following cDNA synthesis with four different commercial kits. We have identified inefficiencies and limitations as well as proposed ways to circumvent identified obstacles. Lastly, we show that we can apply these criteria to a model system to confidently quantify miRNA copy number. Our measurement technique is a novel way to quantify specific miRNA copy number in a single sample, without using standard curves for individual experiments. Our methodology can be used for validation and control measurements, as well as a diagnostic technique that allows scientists, technicians, clinicians, and regulators to base miRNA measures on a single unit of measurement rather than a ratio of values. PMID:29145448

  4. Fast probe of local electronic states in nanostructures utilizing a single-lead quantum dot

    PubMed Central

    Otsuka, Tomohiro; Amaha, Shinichi; Nakajima, Takashi; Delbecq, Matthieu R.; Yoneda, Jun; Takeda, Kenta; Sugawara, Retsu; Allison, Giles; Ludwig, Arne; Wieck, Andreas D.; Tarucha, Seigo

    2015-01-01

    Transport measurements are powerful tools to probe electronic properties of solid-state materials. To access properties of local electronic states in nanostructures, such as local density of states, electronic distribution and so on, micro-probes utilizing artificial nanostructures have been invented to perform measurements in addition to those with conventional macroscopic electronic reservoirs. Here we demonstrate a new kind of micro-probe: a fast single-lead quantum dot probe, which utilizes a quantum dot coupled only to the target structure through a tunneling barrier and fast charge readout by RF reflectometry. The probe can directly access the local electronic states with wide bandwidth. The probe can also access more electronic states, not just those around the Fermi level, and the operations are robust against bias voltages and temperatures. PMID:26416582

  5. Transcap: A new integrated hybrid supercapacitor and electrolyte-gated transistor device (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Santato, Clara

    2015-10-01

    The boom in multifunctional, flexible, and portable electronics and the increasing need of low-energy cost and autonomy for applications ranging from wireless sensor networks for smart environments to biomedical applications are triggering research efforts towards the development of self-powered sustainable electronic devices. Within this context, the coupling of electronic devices (e.g. sensors, transistors) with small size energy storage systems (e.g. micro-batteries or micro-supercapacitors) is actively pursued. Micro-electrochemical supercapacitors are attracting much attention in electronics for their capability of delivering short power pulses with high stability over repeated charge/discharge cycling. For their high specific pseudocapacitance, electronically conducting polymers are well known as positive materials for hybrid supercapacitors featuring high surface carbon negative electrodes. The processability of both polymer and carbon is of great relevance for the development of flexible miniaturised devices. Electronically conducting polymers are even well known to feature an electronic conductivity that depends on their oxidation (p-doped state) and that it is modulated by the polymer potential. This property and the related pseudocapacitive response make polymer very attracting channel materials for electrolyte-gated (EG) transistors. Here, we propose a novel concept of "Trans-capacitor", an integrated device that exhibits the storage properties of a polymer/carbon hybrid supercapacitor and the low-voltage operation of an electrolyte-gated transistor.

  6. Study on the steady operating state of a micro-pulse electron gun

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kui, Zhou; Xing, Luo; Institute of Applied Electronics, Chinese Academy of Engineering Physics, Mianyang 621900

    Micro-pulse electron gun (MPG) employs the basic concept of multipacting to produce high-current and short-pulse electron beams from a radio-frequency (RF) cavity. The concept of MPG has been proposed for more than two decades. However, the unstable operating state of MPG vastly obstructs its practical applications. This paper presents a study on the steady operating state of a micro-pulse electron gun with theory and experiments. The requirements for the steady operating state are proposed through the analysis of the interaction between the RF cavity and the beam load. Accordingly, a MPG cavity with the frequency of 2856 MHz has been designed,more » constructed, and tested. Some primary experiments have been finished. Both the unstable and stable operating states of the MPG have been observed. The stable output beam current has been detected at about 3.8 mA. Further experimental study is under way now.« less

  7. Electrothermal energy conversion using electron gas volumetric change inside semiconductors

    NASA Astrophysics Data System (ADS)

    Yazawa, K.; Shakouri, A.

    2016-07-01

    We propose and analyze an electrothermal energy converter using volumetric changes in non-equilibrium electron gas inside semiconductors. The geometric concentration of electron gas under an electric field increases the effective pressure of the electrons, and then a barrier filters out cold electrons, acting like a valve. Nano- and micro-scale features enable hot electrons to arrive at the contact in a short enough time to avoid thermalization with the lattice. Key length and time scales, preliminary device geometry, and anticipated efficiency are estimated for electronic analogs of Otto and Brayton power generators and Joule-Thomson micro refrigerators on a chip. The power generators convert the energy of incident photons from the heat source to electrical current, and the refrigerator can reduce the temperature of electrons in a semiconductor device. The analytic calculations show that a large energy conversion efficiency or coefficient of performance may be possible.

  8. Electrothermal energy conversion using electron gas volumetric change inside semiconductors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yazawa, K.; Shakouri, A.

    2016-07-25

    We propose and analyze an electrothermal energy converter using volumetric changes in non-equilibrium electron gas inside semiconductors. The geometric concentration of electron gas under an electric field increases the effective pressure of the electrons, and then a barrier filters out cold electrons, acting like a valve. Nano- and micro-scale features enable hot electrons to arrive at the contact in a short enough time to avoid thermalization with the lattice. Key length and time scales, preliminary device geometry, and anticipated efficiency are estimated for electronic analogs of Otto and Brayton power generators and Joule-Thomson micro refrigerators on a chip. The powermore » generators convert the energy of incident photons from the heat source to electrical current, and the refrigerator can reduce the temperature of electrons in a semiconductor device. The analytic calculations show that a large energy conversion efficiency or coefficient of performance may be possible.« less

  9. Integrated micro-electro-mechanical sensor development for inertial applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Allen, J.J.; Kinney, R.D.; Sarsfield, J.

    Electronic sensing circuitry and micro electro mechanical sense elements can be integrated to produce inertial instruments for applications unheard of a few years ago. This paper will describe the Sandia M3EMS fabrication process, inertial instruments that have been fabricated, and the results of initial characterization tests of micro-machined accelerometers.

  10. Fabrication of core-shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying

    NASA Astrophysics Data System (ADS)

    Wang, Yazhou; Zhang, Yiqiong; Wang, Bochu; Cao, Yang; Yu, Qingsong; Yin, Tieying

    2013-06-01

    The study aimed at constructing a novel drug delivery system for programmable multiple drug release controlled with core-shell structure. The core-shell structure consisted of chitosan nanoparticles as core and polyvinylpyrrolidone micro/nanocoating as shell to form core-shell micro/nanoparticles, which was fabricated by ionic gelation and emulsion electrospray methods. As model drug agents, Naproxen and rhodamine B were encapsulated in the core and shell regions, respectively. The core-shell micro/nanoparticles thus fabricated were characterized and confirmed by scanning electron microscope, transmission electron microscope, and fluorescence optical microscope. The core-shell micro/nanoparticles showed good release controllability through drug release experiment in vitro. It was noted that a programmable release pattern for dual drug agents was also achieved by adjusting their loading regions in the core-shell structures. The results indicate that emulsion electrospraying technology is a promising approach in fabrication of core-shell micro/nanoparticles for programmable dual drug release. Such a novel multi-drug delivery system has a potential application for the clinical treatment of cancer, tuberculosis, and tissue engineering.

  11. Contact Resistance Evolution and Degradation of Highly Cycled Micro-Contacts

    DTIC Science & Technology

    2014-03-27

    i List of Acronyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ii I. Introduction...scanning electron microscope EDS energy dispersive X-ray spectroscopy ii CONTACT RESISTANCE EVOLUTION AND DEGRADATION OF HIGHLY CYCLED MICRO-CONTACTS I

  12. 49 CFR 213.241 - Inspection records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... inspection; (2) Track inspected, including beginning and end points; (3) Location and type of defects found... as originally submitted without corruption or loss of data; (6) Paper copies of electronic records...

  13. 46 CFR 10.403 - General standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... conducive to learning; (2) Have the necessary equipment, including simulators where appropriate, sufficient...) Effective March 24, 2014, keep physical or electronic copies of the following records for at least 5 years...

  14. 10 CFR 73.70 - Records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... copy throughout the required retention period. The record may also be stored in electronic media with..., alarm check, and tamper indication that identifies the type of alarm, location, alarm circuit, date, and...

  15. Stability assessment of a multi-port power electronic interface for hybrid micro-grid applications

    NASA Astrophysics Data System (ADS)

    Shamsi, Pourya

    Migration to an industrial society increases the demand for electrical energy. Meanwhile, social causes for preserving the environment and reducing pollutions seek cleaner forms of energy sources. Therefore, there has been a growth in distributed generation from renewable sources in the past decade. Existing regulations and power system coordination does not allow for massive integration of distributed generation throughout the grid. Moreover, the current infrastructures are not designed for interfacing distributed and deregulated generation. In order to remedy this problem, a hybrid micro-grid based on nano-grids is introduced. This system consists of a reliable micro-grid structure that provides a smooth transition from the current distribution networks to smart micro-grid systems. Multi-port power electronic interfaces are introduced to manage the local generation, storage, and consumption. Afterwards, a model for this micro-grid is derived. Using this model, the stability of the system under a variety of source and load induced disturbances is studied. Moreover, pole-zero study of the micro-grid is performed under various loading conditions. An experimental setup of this micro-grid is developed, and the validity of the model in emulating the dynamic behavior of the system is verified. This study provides a theory for a novel hybrid micro-grid as well as models for stability assessment of the proposed micro-grid.

  16. 10 CFR 2.811 - Filing of standard design certification application; required copies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (301) 415-7163, or toll free on (800) 368-5642, or send e-mail to [email protected] on these subject... standard design certification, including all amendments to the applications, must be sent either by mail... example, via Electronic Information Exchange, e-mail, or CD-ROM. Electronic submissions must be made in a...

  17. 10 CFR 2.811 - Filing of standard design certification application; required copies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (301) 415-7163, or toll free on (800) 368-5642, or send e-mail to [email protected] on these subject... standard design certification, including all amendments to the applications, must be sent either by mail... example, via Electronic Information Exchange, e-mail, or CD-ROM. Electronic submissions must be made in a...

  18. 10 CFR 2.811 - Filing of standard design certification application; required copies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (301) 415-7163, or toll free on (800) 368-5642, or send e-mail to [email protected] on these subject... standard design certification, including all amendments to the applications, must be sent either by mail... example, via Electronic Information Exchange, e-mail, or CD-ROM. Electronic submissions must be made in a...

  19. 75 FR 16817 - 2010 Scientific Meeting of the National Antimicrobial Resistance Monitoring System; Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... resistance monitoring and research, including activities in other national programs. Date and Time: The... space available basis beginning at 8 a.m. on the day of the meeting. If you need special accommodations... electronic comments to http://www.regulations.gov . Submit a single copy of electronic comments or two paper...

  20. 75 FR 45609 - Commission Information Collection Activities (FERC-542); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... electronically (eFiled) or in paper format, and should refer to Docket No. IC10-542-000. Documents must be.... Commenters making an eFiling should not make a paper filing. Commenters that are not able to file electronically must send an original and two (2) paper copies of their comments to: Federal Energy Regulatory...

  1. 76 FR 799 - Publication of Year 2010 Form M-1 With Electronic Filing Option, Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ...-EBSA (3272). Questions on completing the form are being directed to the EBSA help desk at (202) 693-8360. For questions regarding the electronic filing capability, contact the EBSA computer help desk at... working together with administrators to help them comply with this filing requirement. Copies of the Form...

  2. Automated Methods to Extract Patient New Information from Clinical Notes in Electronic Health Record Systems

    ERIC Educational Resources Information Center

    Zhang, Rui

    2013-01-01

    The widespread adoption of Electronic Health Record (EHR) has resulted in rapid text proliferation within clinical care. Clinicians' use of copying and pasting functions in EHR systems further compounds this by creating a large amount of redundant clinical information in clinical documents. A mixture of redundant information (especially outdated…

  3. 78 FR 51754 - Request To Modify License by Replacing Security Plan With New Radiation Safety Plan; U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... by the presiding officer that the filing demonstrates good cause by satisfying the three factors in... documents over the Internet, or in some cases to mail copies on electronic storage media. Participants may... holidays. Participants who believe that they have a good cause for not submitting documents electronically...

  4. 77 FR 11173 - Renewal of Facility Operating License No. NPF-30, Union Electric Company, Callaway Plant, Unit 1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... the internet, or in some cases to mail copies on electronic storage media. Participants may not submit.... Participants who believe that they have a good cause for not submitting documents electronically must file an.... Participants are requested not to include personal privacy information, such as social security numbers, home...

  5. 75 FR 10519 - Notice of License Amendment Request by the Worcester Polytechnic Institute for Approval of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... on electronic storage media. Participants may not submit paper copies of their filings unless they... holidays. Participants who believe that they have a good cause for not submitting documents electronically..., such as social security numbers, home addresses, or home phone numbers in their filings, unless an NRC...

  6. Advanced Electronic Technology

    DTIC Science & Technology

    1977-11-15

    Electronics 15 III. Materials Research 15 TV. Microelectronics 16 V. Surface- Wave Technology 16 DATA SYSTEMS DIVISION 2 INTRODUCTION This...Processing Digital Voice Processing Packet Speech Wideband Integrated Voice/Data Technology Radar Signal Processing Technology Nuclear Safety Designs...facilities make it possible to track the status of these jobs, retrieve their job control language listings, and direct a copy of printed or punched

  7. Can E-Textbooks Help Save the Planet? It Depends on You

    ERIC Educational Resources Information Center

    Gattiker, Thomas F.; Lowe, Scott E.

    2012-01-01

    Electronic textbooks, often lauded as a cheaper alternative to hard copies, may also seem like a perfect way for colleges to reduce their greenhouse-gas emissions. Many institutions encourage use of e-books, and one state, California, has required that all textbooks used in college classes be made available electronically by 2020. In a sign of…

  8. 76 FR 30995 - Renewed and Amended Memorandum of Understanding (MOU) Assigning Environmental Responsibilities to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    .... The public is invited to comment on any aspect of the proposed MOU, including the scope of..., between 9 a.m. and 5 p.m. (EST), Monday through Friday, except Federal holidays. Docket: For access to the... . SUPPLEMENTARY INFORMATION: Electronic Access An electronic copy of this notice may be downloaded using a...

  9. 78 FR 78355 - Hydro Green Energy, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... (10) a new single-circuit 230-kilovolt transmission line approximately 12 miles in length. The... intent must meet the requirements of 18 CFR 4.36. The Commission strongly encourages electronic filing... (toll free), or (202) 502- 8659 (TTY). In lieu of electronic filing, please send a paper copy to...

  10. Direct electronic communication at bio-interfaces assisted by layered-metal-hydroxide slab arrays with controlled nano-micro structures.

    PubMed

    An, Zhe; He, Jing

    2011-10-28

    The electronic transfer (eT) at bio-interfaces has been achieved by orientating 2D inorganic slabs in a regular arrangement with the slab ab-planes vertical to the electrode substrate. The eT rate is effectively promoted by tuning the nano-micro scale structures of perpendicular LDH arrays. This journal is © The Royal Society of Chemistry 2011

  11. Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Acciarri, R.; et al.

    The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outsidemore » the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. This noise level is significantly lower than previous experiments utilizing warm front-end electronics.« less

  12. Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Acciarri, R.; Adams, C.; An, R.

    The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outsidemore » the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. In conclusion, this noise level is significantly lower than previous experiments utilizing warm front-end electronics.« less

  13. Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC

    DOE PAGES

    Acciarri, R.; Adams, C.; An, R.; ...

    2017-08-04

    The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outsidemore » the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. In conclusion, this noise level is significantly lower than previous experiments utilizing warm front-end electronics.« less

  14. Improving Information Management at Mare Island Naval Shipyard.

    DTIC Science & Technology

    1987-03-01

    copy reports [Ref. 8: pp. 1-41. C. PRIME TOKEN RING The prime ring is a token-type computer network linking five PRIME computers electronically . Each...the PRIME net are for news (a bulletin board), electronic mail, word processing, and data filing. d 4 o, " ,, " "." ’-" r...communications application) This is a group of general-purpose programs that includes word processing. electronic mail, and spreadsheet applications. Access is

  15. Pediatric Voiding Cystourethrogram

    MedlinePlus

    ... the area being examined by making it appear dark (or by electronically reversing the image contrast to ... Disclaimer This information is copied from the RadiologyInfo Web site (http://www.radiologyinfo.org) which is dedicated ...

  16. The effect of redox-active cyanomanganese(I) ligands on intramolecular electron transfer to, and alkyne alignment in, M(CO)(RC[triple bond, length as m-dash]CR)Tp' (M = Mo or W) units.

    PubMed

    Adams, Christopher J; Connelly, Neil G; Onganusorn, Sriwipha

    2009-04-28

    The complexes [(eta-C(5)Me(5))(ON)LMn(micro-CN)M(CO)(RC[triple bond, length as m-dash]CR)Tp'](+) (L = CNXyl, M = Mo; L = CNBu(t), M = Mo or W, R = Ph or Me) and trans- or cis-[(dppm){(EtO)(3)P}(OC)(2)Mn(micro-CN)M(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+), and their linkage isomers [(eta-C(5)Me(5))(ON)LMn(micro-NC)M(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+) and trans- or cis-[(dppm){(EtO)(3)P}(OC)(2)Mn(micro-NC)M(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+), undergo two one-electron oxidations. The complexes [(eta-C(5)Me(5))(ON)LMn(micro-XY)M(CO)(RC[triple bond, length as m-dash]CR)Tp'](+) (XY = CN or NC) are oxidised first at the N-bound metal centre and then at the C-bound centre. For [(dppm){(EtO)(3)P}(OC)(2)Mn(micro-XY)M(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+), the trans isomers are first oxidised at manganese whereas the cis isomers are first oxidised at M. Thus, the order of one-electron oxidation of the two series of binuclear monocations is influenced by linkage isomerisation of the cyanide bridge and cis-trans isomerisation of the Mn(CO)(2) group. IR spectroscopic changes on reaction of Ag(+) with [(eta-C(5)Me(5))(ON)(Bu(t)NC)Mn(micro-CN)W(CO)(MeC[triple bond, length as m-dash]CMe)Tp'](+) are consistent with one-electron at the N-bound tungsten centre. Likewise, trans-[(dppm){(EtO)(3)P}(OC)(2)Mn(micro-NC)M(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+) (M = Mo or W) give the stable dications [(dppm){(EtO)(3)P}(OC)(2)Mn(micro-NC)M(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](2+). Significantly longer Mn-P bond distances in trans-[(dppm){(EtO)(3)P}(OC)(2)Mn(micro-NC)Mo(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](2+) than in trans-[(dppm){(EtO)(3)P}(OC)(2)Mn(micro-NC)Mo(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+) are consistent with one-electron oxidation first at Mn(I); the alignment of the (CN)Mn(CO)(2){P(OEt)(3)}(dppm) fragment relative to the alkyne in trans-[(dppm){(EtO)(3)P}(OC)(2)Mn(micro-NC)Mo(CO)(PhC[triple bond, length as m-dash]CPh)Tp'](+) suggests it acts as a pi-acceptor, in contrast to related species such as trans-(NC)Mn(CO)(2){P(OEt)(3)}(dppm) and (NC)Mn(NO){P(OPh)(3)}(pi-C(5)H(4)Me) which behave as simple N-donors.

  17. MicroED Structure of Au146(p-MBA)57 at Subatomic Resolution Reveals a Twinned FCC Cluster.

    PubMed

    Vergara, Sandra; Lukes, Dylan A; Martynowycz, Michael W; Santiago, Ulises; Plascencia-Villa, Germán; Weiss, Simon C; de la Cruz, M Jason; Black, David M; Alvarez, Marcos M; López-Lozano, Xochitl; Barnes, Christopher O; Lin, Guowu; Weissker, Hans-Christian; Whetten, Robert L; Gonen, Tamir; Yacaman, Miguel Jose; Calero, Guillermo

    2017-11-16

    Solving the atomic structure of metallic clusters is fundamental to understanding their optical, electronic, and chemical properties. Herein we present the structure of the largest aqueous gold cluster, Au 146 (p-MBA) 57 (p-MBA: para-mercaptobenzoic acid), solved by electron micro-diffraction (MicroED) to subatomic resolution (0.85 Å) and by X-ray diffraction at atomic resolution (1.3 Å). The 146 gold atoms may be decomposed into two constituent sets consisting of 119 core and 27 peripheral atoms. The core atoms are organized in a twinned FCC structure, whereas the surface gold atoms follow a C 2 rotational symmetry about an axis bisecting the twinning plane. The protective layer of 57 p-MBAs fully encloses the cluster and comprises bridging, monomeric, and dimeric staple motifs. Au 146 (p-MBA) 57 is the largest cluster observed exhibiting a bulk-like FCC structure as well as the smallest gold particle exhibiting a stacking fault.

  18. Investigations on Mechanical Behaviour of Micro Graphite Particulates Reinforced Al-7Si Alloy Composites

    NASA Astrophysics Data System (ADS)

    Nagaraj, N.; Mahendra, K. V.; Nagaral, Madeva

    2018-02-01

    Micro particulates reinforced metal matrix composites are finding wide range of applications in automotive and sports equipment manufacturing industries. In the present study, an attempt has been made to develop Al-7Si-micro graphite particulates reinforced composites by using liquid melt method. 3 and 6 wt. % of micro graphite particulates were added to the Al-7Si base matrix. Microstructural characterization was done by using scanning electron microscope and energy dispersive spectroscope. Mechanical behaviour of Al-7Si-3 and 6 wt. % composites were evaluated as per ASTM standards. Scanning electron micrographs revealed the uniform distribution of micro graphite particulates in the Al-7Si alloy matrix. EDS analysis confirmed the presence of B and C elements in graphite reinforced composites. Further, it was noted that ultimate tensile and yield strength of Al-7Si alloy increased with the addition of 3 and 6wt. % of graphite particulates. Hardness of graphite reinforced composites was lesser than the base matrix.

  19. Secure communications using nonlinear silicon photonic keys.

    PubMed

    Grubel, Brian C; Bosworth, Bryan T; Kossey, Michael R; Cooper, A Brinton; Foster, Mark A; Foster, Amy C

    2018-02-19

    We present a secure communication system constructed using pairs of nonlinear photonic physical unclonable functions (PUFs) that harness physical chaos in integrated silicon micro-cavities. Compared to a large, electronically stored one-time pad, our method provisions large amounts of information within the intrinsically complex nanostructure of the micro-cavities. By probing a micro-cavity with a rapid sequence of spectrally-encoded ultrafast optical pulses and measuring the lightwave responses, we experimentally demonstrate the ability to extract 2.4 Gb of key material from a single micro-cavity device. Subsequently, in a secure communication experiment with pairs of devices, we achieve bit error rates below 10 -5 at code rates of up to 0.1. The PUFs' responses are never transmitted over the channel or stored in digital memory, thus enhancing the security of the system. Additionally, the micro-cavity PUFs are extremely small, inexpensive, robust, and fully compatible with telecommunications infrastructure, components, and electronic fabrication. This approach can serve one-time pad or public key exchange applications where high security is required.

  20. Recent advances in design and fabrication of on-chip micro-supercapacitors

    NASA Astrophysics Data System (ADS)

    Beidaghi, Majid; Wang, Chunlei

    2012-06-01

    Recent development in miniaturized electronic devices has increased the demand for power sources that are sufficiently compact and can potentially be integrated on a chip with other electronic components. Miniaturized electrochemical capacitors (EC) or micro-supercapacitors have great potential to complement or replace batteries and electrolytic capacitors in a variety of applications. Recently, we have developed several types of micro-supercapacitors with different structural designs and active materials. Carbon-Microelectromechanical Systems (C-MEMS) with three dimensional (3D) interdigital structures are employed both as electrode material for electric double layer capacitor (EDLC) or as three dimensional (3D) current collectors of pseudo-capacitive materials. More recently, we have also developed microsupercapacitor based on hybrid graphene and carbon nanotube interdigital structures. In this paper, the recent advances in design and fabrication of on-chip micro-supercapacitors are reviewed.

  1. Experimental study of multichromatic terahertz wave propagation through planar micro-channels

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shin, Young-Min -Min; Northern Illinois Univ., Dekalb, IL; Fermi National Accelerator Lab.

    2012-04-10

    Previous theoretical and numerical studies [Y. M. Shin and L. R. Barnett, Appl. Phys. Lett. 92, 091501 (2008) and Y. M. Shin et al., Appl. Phys. Lett. 93, 221504 (2008)] have reported that a planar micro-channel with an asymmetric corrugation array supports strongly confined propagation of broadband THz plasmonic waves. The highly broad spectral response is experimentally demonstrated in the near-THz regime of 0.19-0.265 THz. Signal reflection and transmission tests on the three designed micro-channels including directional couplers resulted in a full-width-half-maximum bandwidth of ~ 50-60GHz with an insertion loss of approximately -5 dB, which is in good agreement withmore » simulation data. As a result, these micro-structures can be utilized for free electron beam and electronic/optic integrated devices« less

  2. Laser direct writing of carbon/Au composite electrodes for high-performance micro-supercapacitors

    NASA Astrophysics Data System (ADS)

    Cai, Jinguang; Watanabe, Akira; Lv, Chao

    2017-02-01

    Micro-supercapacitors with small size, light weight, flexibility while maintaining high energy and power output are required for portable miniaturized electronics. The fabrication methods and materials should be cost-effective, scalable, and easily integrated to current electronic industry. Carbon materials have required properties for high-performance flexible supercapacitors, including high specific surface areas, electrochemical stability, and high electrical conductivity, as well as the high mechanical tolerance. Laser direct writing method is a non-contact, efficient, single-step fabrication technique without requirements of masks, post-processing, and complex clean room, which is a useful patterning technique, and can be easily integrated with current electronic product lines for commercial use. Previously we have reported micro-supercapacitors fabricated by laser direct writing on polyimide films in air or Ar, which showed highcapacitive performance. However, the conductivity of the carbon materials is still low for fast charge-discharge use. Here, we demonstrated the fabrication of flexible carbon/Au composite high-performance MSCs by first laser direct writing on commercial polyimide films followed by spin-coating Au nanoparticles ink and second in-situ laser direct writing using the low-cost semiconductor laser. As-prepared micro-supercapacitors show an improved conductivity and capacitance of 1.17 mF/cm2 at a high scanning rate of 10,000 mV/s, which is comparable to the reported capacitance of carbon-based micro-supercapacitors. In addition, the micro-supercapacitors have high bend tolerance and long-cycle stability.

  3. Variability among electronic cigarettes in the pressure drop, airflow rate, and aerosol production.

    PubMed

    Williams, Monique; Talbot, Prue

    2011-12-01

    This study investigated the performance of electronic cigarettes (e-cigarettes), compared different models within a brand, compared identical copies of the same model within a brand, and examined performance using different protocols. Airflow rate required to generate aerosol, pressure drop across e-cigarettes, and aerosol density were examined using three different protocols. First 10 puff protocol: The airflow rate required to produce aerosol and aerosol density varied among brands, while pressure drop varied among brands and between the same model within a brand. Total air hole area correlated with pressure drop for some brands. Smoke-out protocol: E-cigarettes within a brand generally performed similarly when puffed to exhaustion; however, there was considerable variation between brands in pressure drop, airflow rate required to produce aerosol, and the total number of puffs produced. With this protocol, aerosol density varied significantly between puffs and gradually declined. CONSECUTIVE TRIAL PROTOCOL: Two copies of one model were subjected to 11 puffs in three consecutive trials with breaks between trials. One copy performed similarly in each trial, while the second copy of the same model produced little aerosol during the third trial. The different performance properties of the two units were attributed to the atomizers. There was significant variability between and within brands in the airflow rate required to produce aerosol, pressure drop, length of time cartridges lasted, and production of aerosol. Variation in performance properties within brands suggests a need for better quality control during e-cigarette manufacture.

  4. Micro-Structural Study of Fretting Contact Caused by the Difference of the Tin Plating Thickness

    NASA Astrophysics Data System (ADS)

    Ito, Tetsuya; Sawada, Shigeru; Hattori, Yasuhiro; Saitoh, Yasushi; Tamai, Terutaka; Iida, Kazuo

    In recent years, there has been increasing demand to miniaturize wiring harness connectors in automobiles due to the increasing volume of electronic equipment and the reduction of the installation space allocated for the electronic equipment in automobiles for the comfort of the passengers. With this demand, contact failure caused by the fretting corrosion is expected to become a serious problem. In this report, we examined micro-structural observations of fretting contacts of two different tin plating thicknesses using Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) and so on. Based on the results, we compared the microstructure difference of fretting contact caused by the difference of the tin plating thickness.

  5. 32 CFR 856.7 - Action after final decision.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... potentially affecting monetary entitlement or benefits. DFAS will treat such decisions as claims for payment... information, AFBCMR decisions will be made available for review and copying at an electronic public reading...

  6. 32 CFR 856.7 - Action after final decision.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... potentially affecting monetary entitlement or benefits. DFAS will treat such decisions as claims for payment... information, AFBCMR decisions will be made available for review and copying at an electronic public reading...

  7. 32 CFR 856.7 - Action after final decision.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... potentially affecting monetary entitlement or benefits. DFAS will treat such decisions as claims for payment... information, AFBCMR decisions will be made available for review and copying at an electronic public reading...

  8. 32 CFR 856.7 - Action after final decision.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... potentially affecting monetary entitlement or benefits. DFAS will treat such decisions as claims for payment... information, AFBCMR decisions will be made available for review and copying at an electronic public reading...

  9. 49 CFR 173.199 - Category B infectious substances.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... this section; (ii) Anticoagulants used to stabilize blood or plasma; or (iii) Small quantities of Class... copy or electronic image of these instructions must be retained by the manufacturer and subsequent...

  10. 39 CFR 3050.60 - Miscellaneous reports and documents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... copy form, and in electronic form, if available; (d) Household Diary Study (when completed); (e) Input... each year); (f) Succinct narrative explanations of how the estimates in the most recent Annual...

  11. 39 CFR 3050.60 - Miscellaneous reports and documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... copy form, and in electronic form, if available; (d) Household Diary Study (when completed); (e) Input... each year); (f) Succinct narrative explanations of how the estimates in the most recent Annual...

  12. Determination of electron beam polarization using electron detector in Compton polarimeter with less than 1% statistical and systematic uncertainty

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Narayan, Amrendra

    2015-05-01

    The Q-weak experiment aims to measure the weak charge of proton with a precision of 4.2%. The proposed precision on weak charge required a 2.5% measurement of the parity violating asymmetry in elastic electron - proton scattering. Polarimetry was the largest experimental contribution to this uncertainty and a new Compton polarimeter was installed in Hall C at Jefferson Lab to make the goal achievable. In this polarimeter the electron beam collides with green laser light in a low gain Fabry-Perot Cavity; the scattered electrons are detected in 4 planes of a novel diamond micro strip detector while the back scatteredmore » photons are detected in lead tungstate crystals. This diamond micro-strip detector is the first such device to be used as a tracking detector in a nuclear and particle physics experiment. The diamond detectors are read out using custom built electronic modules that include a preamplifier, a pulse shaping amplifier and a discriminator for each detector micro-strip. We use field programmable gate array based general purpose logic modules for event selection and histogramming. Extensive Monte Carlo simulations and data acquisition simulations were performed to estimate the systematic uncertainties. Additionally, the Moller and Compton polarimeters were cross calibrated at low electron beam currents using a series of interleaved measurements. In this dissertation, we describe all the subsystems of the Compton polarimeter with emphasis on the electron detector. We focus on the FPGA based data acquisition system built by the author and the data analysis methods implemented by the author. The simulations of the data acquisition and the polarimeter that helped rigorously establish the systematic uncertainties of the polarimeter are also elaborated, resulting in the first sub 1% measurement of low energy (?1 GeV) electron beam polarization with a Compton electron detector. We have demonstrated that diamond based micro-strip detectors can be used for tracking in a high radiation environment and it has enabled us to achieve the desired precision in the measurement of the electron beam polarization which in turn has allowed the most precise determination of the weak charge of the proton.« less

  13. Determination of electron beam polarization using electron detector in Compton polarimeter with less than 1% statistical and systematic uncertainty

    NASA Astrophysics Data System (ADS)

    Narayan, Amrendra

    The Q-weak experiment aims to measure the weak charge of proton with a precision of 4.2%. The proposed precision on weak charge required a 2.5% measurement of the parity violating asymmetry in elastic electron - proton scattering. Polarimetry was the largest experimental contribution to this uncertainty and a new Compton polarimeter was installed in Hall C at Jefferson Lab to make the goal achievable. In this polarimeter the electron beam collides with green laser light in a low gain Fabry-Perot Cavity; the scattered electrons are detected in 4 planes of a novel diamond micro strip detector while the back scattered photons are detected in lead tungstate crystals. This diamond micro-strip detector is the first such device to be used as a tracking detector in a nuclear and particle physics experiment. The diamond detectors are read out using custom built electronic modules that include a preamplifier, a pulse shaping amplifier and a discriminator for each detector micro-strip. We use field programmable gate array based general purpose logic modules for event selection and histogramming. Extensive Monte Carlo simulations and data acquisition simulations were performed to estimate the systematic uncertainties. Additionally, the Moller and Compton polarimeters were cross calibrated at low electron beam currents using a series of interleaved measurements. In this dissertation, we describe all the subsystems of the Compton polarimeter with emphasis on the electron detector. We focus on the FPGA based data acquisition system built by the author and the data analysis methods implemented by the author. The simulations of the data acquisition and the polarimeter that helped rigorously establish the systematic uncertainties of the polarimeter are also elaborated, resulting in the first sub 1% measurement of low energy (~1GeV) electron beam polarization with a Compton electron detector. We have demonstrated that diamond based micro-strip detectors can be used for tracking in a high radiation environment and it has enabled us to achieve the desired precision in the measurement of the electron beam polarization which in turn has allowed the most precise determination of the weak charge of the proton.

  14. Short-Pulse Laser-Matter Computational Workshop Proceedings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Town, R; Tabak, M

    For three days at the end of August 2004, 55 plasma scientists met at the Four Points by Sheraton in Pleasanton to discuss some of the critical issues associated with the computational aspects of the interaction of short-pulse high-intensity lasers with matter. The workshop was organized around the following six key areas: (1) Laser propagation/interaction through various density plasmas: micro scale; (2) Anomalous electron transport effects: From micro to meso scale; (3) Electron transport through plasmas: From meso to macro scale; (4) Ion beam generation, transport, and focusing; (5) ''Atomic-scale'' electron and proton stopping powers; and (6) K{alpha} diagnostics.

  15. In-Situ Formation of Cobalt-Phosphate Oxygen-Evolving Complex-Anchored Reduced Graphene Oxide Nanosheets for Oxygen Reduction Reaction

    PubMed Central

    Zhao, Zhi-Gang; Zhang, Jing; Yuan, Yinyin; Lv, Hong; Tian, Yuyu; Wu, Dan; Li, Qing-Wen

    2013-01-01

    Oxygen conversion process between O2 and H2O by means of electrochemistry or photochemistry has lately received a great deal of attention. Cobalt-phosphate (Co-Pi) catalyst is a new type of cost-effective artificial oxygen-evolving complex (OEC) with amorphous features during photosynthesis. However, can such Co-Pi OEC also act as oxygen reduction reaction (ORR) catalyst in electrochemical processes? The question remains unanswered. Here for the first time we demonstrate that Co-Pi OEC does be rather active for the ORR. Particularly, Co-Pi OEC anchoring on reduced graphite oxide (rGO) nanosheet is shown to possess dramatically improved electrocatalytic activities. Differing from the generally accepted role of rGO as an “electron reservoir”, we suggest that rGO serves as “peroxide cleaner” in enhancing the electrocatalytic behaviors. The present study may bridge the gap between photochemistry and electrochemistry towards oxygen conversion. PMID:23877331

  16. 36 CFR 1225.22 - When must scheduled records be rescheduled?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... records contain information that is substantially different from the information included in the hard copy.... (4) The electronic records consist of temporary program records maintained in a format other than...

  17. 42 CFR 493.903 - Administrative responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Provide HHS or its designees and participating laboratories with an electronic or a hard copy, or both, of reports of proficiency testing results and all scores for each laboratory's performance in a format as...

  18. 32 CFR 295.3 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... public trust by making the maximum amount of information available to the public, in both hard copy and electronic formats, on the operation and activities of the Department of Defense, consistent with the DoD...

  19. 32 CFR 637.18 - Electronic equipment procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... contain specific authority for the type of equipment to be used, the phone numbers identified as emergency lines and instructions limiting recordings to calls received on the phones so designated. One copy of...

  20. 75 FR 22770 - National Electric Transmission Congestion Study

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Study is available at http://www.oe.energy.gov . DATES: Written comments may be filed electronically in.... Copies of written comments received and other relevant documents and information may be reviewed at http...

  1. 19 CFR 201.41 - Public inspection and copying of records; applicable fees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of transcripts, minutes of Commission meetings, or transcriptions of electronic recordings of Commission meetings, which disclose the identity of each speaker, at the actual cost of transcription or...

  2. 19 CFR 201.41 - Public inspection and copying of records; applicable fees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of transcripts, minutes of Commission meetings, or transcriptions of electronic recordings of Commission meetings, which disclose the identity of each speaker, at the actual cost of transcription or...

  3. Antenna-coupled transition-edge hot-electron microbolometers

    NASA Astrophysics Data System (ADS)

    Ali, Shafinaz; Timbie, Peter T.; Malu, Siddharth; McCammon, Dan; Nelms, Kari L.; Pathak, Rashmi; van der Weide, Daniel W.; Allen, Christine A.; Abrahams, J.; Chervenak, James A.; Hsieh, Wen-Ting; Miller, Timothy M.; Moseley, S. H., Jr.; Stevenson, Thomas R.; Wollack, Edward J.

    2004-10-01

    We are developing a new type of detector for observational cosmology and astrophysical research. Incoming radiation from the sky is coupled to a superconducting microstrip transmission line that terminates in a thin film absorber. At sub-Kelvin temperature, the thermal isolation between the electrons and the lattice makes it possible for the electrons in the small absorber (100's of cubic micro-meter) and superconducting bilayer (Transition Edge Sensor) to heat up by the radiation absorbed by the electrons of the normal absorbing layer. We call this detector a Transition-edge Hot-electron Micro-bolometer (THM). THMs can be fabricated by photo lithography, so it is relatively easy to make matched detectors for a large focal plane array telescope. We report on the thermal properties of Mo/Au THMs with Bi/Au absorbers.

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, ``Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,`` (P.I., M. Reiser); TASK B, ``Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,`` (Co-P.I.`s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, ``Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,`` (Co-P.I.`s, V.L. Granatstein, W. Lawson, M.more » Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks.« less

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,'' (P.I., M. Reiser); TASK B, Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,'' (Co-P.I.'s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,'' (Co-P.I.'s, V.L. Granatstein, W. Lawson, M.more » Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks.« less

  6. Insights on the functional impact of microRNAs present in autism-associated copy number variants.

    PubMed

    Vaishnavi, Varadarajan; Manikandan, Mayakannan; Tiwary, Basant K; Munirajan, Arasambattu Kannan

    2013-01-01

    Autism spectrum disorder is a complex neurodevelopmental disorder that appears during the first three years of infancy and lasts throughout a person's life. Recently a large category of genomic structural variants, denoted as copy number variants (CNVs), were established to be a major contributor of the pathophysiology of autism. To date almost all studies have focussed only on the genes present in the CNV loci, but the impact of non-coding regulatory microRNAs (miRNAs) present in these regions remain largely unexplored. Hence we attempted to elucidate the biological and functional significance of miRNAs present in autism-associated CNV loci and their target genes by using a series of computational tools. We demonstrate that nearly 11% of the CNV loci harbor miRNAs and a few of these miRNAs were previously reported to be associated with autism. A systematic analysis of the CNV-miRNAs based on their interactions with the target genes enabled the identification of top 10 miRNAs namely hsa-miR-590-3p, hsa-miR-944, hsa-miR-570, hsa-miR-34a, hsa-miR-124, hsa-miR-548f, hsa-miR-429, hsa-miR-200b, hsa-miR-195 and hsa-miR-497 as hub molecules. Further, the CNV-miRNAs formed a regulatory loop with transcription factors and their downstream target genes, and annotation of these target genes indicated their functional involvement in neurodevelopment and synapse. Moreover, miRNAs present in deleted and duplicated CNV loci may explain the difference in dosage of the crucial genes controlled by them. These CNV-miRNAs can also impair the global processing and biogenesis of all miRNAs by targeting key molecules in the miRNA pathway. To our knowledge, this is the first report to highlight the significance of CNV-microRNAs and their target genes to contribute towards the genetic heterogeneity and phenotypic variability of autism.

  7. Electronic Spectra from Molecular Dynamics: A Simple Approach.

    DTIC Science & Technology

    1983-10-01

    82.30.Cr. 33.20K. S2.40.1s The authors provided phototypeset copy for this paper using REFER TlL EON, TOFF On UNIX I ELECTRONIC SPECTRA FROM MOLECULAR...Alamos National Laboratory Los Alamos, NM 87545 I. INTRODUCTION In this paper we show how molecular dynamics can be used in a simple manner to com...could equally use Monte Carlo or explicit integration over coordinates to compute equilibrium electronic absorption bands. How- ever, molecular

  8. Reconfigurable Electronics and Non-Volatile Memory Research

    DTIC Science & Technology

    2015-11-10

    Kirtland AFB, NM 87117-5776 2 cys Official Record Copy AFRL /RVSE/Arthur Edwards 1 cy... AFRL -RV-PS- AFRL -RV-PS- TR-2015-0151 TR-2015-0151 RECONFIGURABLE ELECTRONICS AND NON- VOLATILE MEMORY RESEARCH Kristy A. Campbell Boise State... KIRTLAND AIR FORCE BASE, NM 87117-5776 NOTICE AND SIGNATURE PAGE Using Government drawings, specifications, or other data included in this document for

  9. Thermal Transport in Diamond Films for Electronics Thermal Management

    DTIC Science & Technology

    2018-03-01

    AFRL-RY-WP-TR-2017-0219 THERMAL TRANSPORT IN DIAMOND FILMS FOR ELECTRONICS THERMAL MANAGEMENT Samuel Graham Georgia Institute of Technology MARCH...general public, including foreign nationals. Copies may be obtained from the Defense Technical Information Center (DTIC) (http://www.dtic.mil...Signature// JOHN D. BLEVINS, Program Manager ROSS W. DETTMER, Chief Devices for Sensing Branch Devices for Sensing Branch Aerospace Components

  10. Tests of a low-pressure switch protected by a saturating inductor

    NASA Astrophysics Data System (ADS)

    Lauer, E. J.; Birx, D. L.

    1981-10-01

    A triggered low-pressure switch was tested switching a charged capacitor across a damping resistor simulating a transformer. A series saturating inductor protected the switch from electron beam anode damage. The capacitor was 15 micro F and charge voltages up to 50 kV were used. The time to current maximum was 5 to 8 micro S. The current terminated at about 50 micro S and voltage could be reapplied at about 100 micro S.

  11. Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells

    PubMed Central

    Ding, Ding; Xie, Youtao; Li, Kai; Huang, Liping; Zheng, Xuebin

    2018-01-01

    Recently, tantalum has been attracting much attention for its anticorrosion resistance and biocompatibility, and it has been widely used in surface modification for implant applications. To improve its osteogenic differentiation of human bone marrow stem cells (hBMSCs), a micro/nano structure has been fabricated on the tantalum coating surface through the combination of anodic oxidation and plasma spraying method. The morphology, composition, and microstructure of the modified coating were comprehensively studied by employing scanning electron microscopy (SEM), X-ray diffraction (XRD) as well as transmission electron microscopy (TEM). The effects of hierarchical structures as well as micro-porous structure of tantalum coating on the behavior for human bone marrow stem cells (hBMSCs) were evaluated and compared at both cellular and molecular levels in vitro. The experimental results show that a hierarchical micro/nano structure with Ta2O5 nanotubes spread onto a micro-scale tantalum coating has been fabricated successfully, which is confirmed to promote cell adhesion and spreading. Besides, the hierarchical micro/nano tantalum coating can provide 1.5~2.1 times improvement in gene expression, compared with the micro-porous tantalum coating. It demonstrates that it can effectively enhance the proliferation and differentiation of hBMSCs in vitro. PMID:29614022

  12. Micro/Nano Structural Tantalum Coating for Enhanced Osteogenic Differentiation of Human Bone Marrow Stem Cells.

    PubMed

    Ding, Ding; Xie, Youtao; Li, Kai; Huang, Liping; Zheng, Xuebin

    2018-04-03

    Recently, tantalum has been attracting much attention for its anticorrosion resistance and biocompatibility, and it has been widely used in surface modification for implant applications. To improve its osteogenic differentiation of human bone marrow stem cells (hBMSCs), a micro/nano structure has been fabricated on the tantalum coating surface through the combination of anodic oxidation and plasma spraying method. The morphology, composition, and microstructure of the modified coating were comprehensively studied by employing scanning electron microscopy (SEM), X-ray diffraction (XRD) as well as transmission electron microscopy (TEM). The effects of hierarchical structures as well as micro-porous structure of tantalum coating on the behavior for human bone marrow stem cells (hBMSCs) were evaluated and compared at both cellular and molecular levels in vitro. The experimental results show that a hierarchical micro/nano structure with Ta₂O₅ nanotubes spread onto a micro-scale tantalum coating has been fabricated successfully, which is confirmed to promote cell adhesion and spreading. Besides, the hierarchical micro/nano tantalum coating can provide 1.5~2.1 times improvement in gene expression, compared with the micro-porous tantalum coating. It demonstrates that it can effectively enhance the proliferation and differentiation of hBMSCs in vitro.

  13. Synthesis of nanostructured barium phosphate and its application in micro-computed tomography of mouse brain vessels in ex vivo

    NASA Astrophysics Data System (ADS)

    Zhu, Bangshang; Yuan, Falei; Yuan, Xiaoya; Bo, Yang; Wang, Yongting; Yang, Guo-Yuan; Drummen, Gregor P. C.; Zhu, Xinyuan

    2014-02-01

    Micro-computed tomography (micro-CT) is a powerful tool for visualizing the vascular systems of tissues, organs, or entire small animals. Vascular contrast agents play a vital role in micro-CT imaging in order to obtain clear and high-quality images. In this study, a new kind of nanostructured barium phosphate was fabricated and used as a contrast agent for ex vivo micro-CT imaging of blood vessels in the mouse brain. Nanostructured barium phosphate was synthesized through a simple wet precipitation method using Ba(NO3)2, and (NH4)2HPO4 as starting materials. The physiochemical properties of barium phosphate were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and thermal analysis. Furthermore, the impact of the produced nanostructures on cell viability was evaluated via the MTT assay, which generally showed low to moderate cytotoxicity. Finally, the animal test images demonstrated that the use of nanostructured barium phosphate as a contrast agent in Micro-CT imaging produced sharp images with excellent contrast. Both major vessels and the microvasculature were clearly observable in the imaged mouse brain. Overall, the results indicate that nanostructured barium phosphate is a potential and useful vascular contrast agent for micro-CT imaging.

  14. EDI at the Jet Propulsion Laboratory Library

    NASA Technical Reports Server (NTRS)

    Amago, B.

    1994-01-01

    The JPL Library and Information Center orders and claims material elecronically whenever feasible. The NASA Aerospace Research Information Network (ARIN) is used to order books for the library collection; BIP Plus on CD-ROM is used to order office copies. Paper copies of invoices are processed when material is received. Subscriptions are ordered using the vendor's online system; monthly and annual invoices are received both in paper and electronic format (diskette of FTP). Library-developed dbase programs complement or duplicate functions available through ARIN and/or the JPL institutional accounting system.

  15. MEMS in Space Systems

    NASA Technical Reports Server (NTRS)

    Lyke, J. C.; Michalicek, M. A.; Singaraju, B. K.

    1995-01-01

    Micro-electro-mechanical systems (MEMS) provide an emerging technology that has the potential for revolutionizing the way space systems are designed, assembled, and tested. The high launch costs of current space systems are a major determining factor in the amount of functionality that can be integrated in a typical space system. MEMS devices have the ability to increase the functionality of selected satellite subsystems while simultaneously decreasing spacecraft weight. The Air Force Phillips Laboratory (PL) is supporting the development of a variety of MEMS related technologies as one of several methods to reduce the weight of space systems and increase their performance. MEMS research is a natural extension of PL research objectives in micro-electronics and advanced packaging. Examples of applications that are under research include on-chip micro-coolers, micro-gyroscopes, vibration sensors, and three-dimensional packaging technologies to integrate electronics with MEMS devices. The first on-orbit space flight demonstration of these and other technologies is scheduled for next year.

  16. A study on (K, Na) NbO3 based multilayer piezoelectric ceramics micro speaker

    NASA Astrophysics Data System (ADS)

    Gao, Renlong; Chu, Xiangcheng; Huan, Yu; Sun, Yiming; Liu, Jiayi; Wang, Xiaohui; Li, Longtu

    2014-10-01

    A flat panel micro speaker was fabricated from (K, Na) NbO3 (KNN)-based multilayer piezoelectric ceramics by a tape casting and cofiring process using Ag-Pd alloys as an inner electrode. The interface between ceramic and electrode was investigated by scanning electron microscope (SEM) and transmission electron microscope (TEM). The acoustic response was characterized by a standard audio test system. We found that the micro speaker with dimensions of 23 × 27 × 0.6 mm3, using three layers of 30 μm thickness KNN-based ceramic, has a high average sound pressure level (SPL) of 87 dB, between 100 Hz-20 kHz under five voltage. This result was even better than that of lead zirconate titanate (PZT)-based ceramics under the same conditions. The experimental results show that the KNN-based multilayer ceramics could be used as lead free piezoelectric micro speakers.

  17. A design multifunctional plasmonic optical device by micro ring system

    NASA Astrophysics Data System (ADS)

    Pornsuwancharoen, N.; Youplao, P.; Amiri, I. S.; Ali, J.; Yupapin, P.

    2018-03-01

    A multi-function electronic device based on the plasmonic circuit is designed and simulated by using the micro-ring system. From which a nonlinear micro-ring resonator is employed and the selected electronic devices such as rectifier, amplifier, regulator and filter are investigated. A system consists of a nonlinear micro-ring resonator, which is known as a modified add-drop filter and made of an InGaAsP/InP material. The stacked waveguide of an InGaAsP/InP - graphene -gold/silver is formed as a part of the device, the required output signals are formed by the specific control of input signals via the input and add ports. The material and device aspects are reviewed. The simulation results are obtained using the Opti-wave and MATLAB software programs, all device parameters are based on the fabrication technology capability.

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morioka, A.; Misawa, H.; Obara, T.

    Solar micro-type III radio bursts are elements of the so-called type III storms and are characterized by short-lived, continuous, and weak emissions. Their frequency of occurrence with respect to radiation power is quite different from that of ordinary type III bursts, suggesting that the generation process is not flare-related, but due to some recurrent acceleration processes around the active region. We examine the relationship of micro-type III radio bursts with coronal streamers. We also explore the propagation channel of bursts in the outer corona, the acceleration process, and the escape route of electron beams. It is observationally confirmed that micro-typemore » III bursts occur near the edge of coronal streamers. The magnetic field line of the escaping electron beams is tracked on the basis of the frequency drift rate of micro-type III bursts and the electron density distribution model. The results demonstrate that electron beams are trapped along closed dipolar field lines in the outer coronal region, which arise from the interface region between the active region and the coronal hole. A 22 year statistical study reveals that the apex altitude of the magnetic loop ranges from 15 to 50 R{sub S}. The distribution of the apex altitude has a sharp upper limit around 50 R{sub S} suggesting that an unknown but universal condition regulates the upper boundary of the streamer dipolar field.« less

  19. The characterization of canvas painting by the Serbian artist Milo Milunović using X-ray fluorescence, micro-Raman and FTIR spectroscopy

    NASA Astrophysics Data System (ADS)

    Damjanović, Lj.; Gajić-Kvaščev, M.; Đurđević, J.; Andrić, V.; Marić-Stojanović, M.; Lazić, T.; Nikolić, S.

    2015-10-01

    A canvas painting by Milo Milunović "The Inspiration of the poet" was studied by energy dispersive X-Ray fluorescence (EDXRF), micro-Raman and Fourier transform infrared (FTIR) spectroscopy in order to identify materials used by the artist and his painting technique. Study is perfomed combining in situ non-destructive method with the preparation and study of cross-section samples and raw fragments of the samples. Milo Milunović, an eminent painter from Balkan region, made a copy of the Nicolas Poussin's original painting in Louvre in 1926/27. Obtained results revealed following pigments on the investigated canvas painting: vermilion, minium, cobalt blue, ultramarine, lead white, zinc white, cadmium yellow, chrome-based green pigment and several earth pigments - red and yellow ocher, green earth and umber. Ground layer was made of lead white mixed with calcium carbonate.

  20. 17 CFR 229.1118 - (Item 1118) Reports and additional information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Commission maintains an Internet site that contains reports, proxy and information statements, and other... electronic or paper copies of those filings and other reports free of charge upon request. [70 FR 1597, Jan...

  1. 17 CFR 229.1118 - (Item 1118) Reports and additional information.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Commission maintains an Internet site that contains reports, proxy and information statements, and other... electronic or paper copies of those filings and other reports free of charge upon request. [70 FR 1597, Jan...

  2. 17 CFR 229.1118 - (Item 1118) Reports and additional information.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Commission maintains an Internet site that contains reports, proxy and information statements, and other... electronic or paper copies of those filings and other reports free of charge upon request. [70 FR 1597, Jan...

  3. 17 CFR 229.1118 - (Item 1118) Reports and additional information.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Commission maintains an Internet site that contains reports, proxy and information statements, and other... electronic or paper copies of those filings and other reports free of charge upon request. [70 FR 1597, Jan...

  4. 17 CFR 229.1118 - (Item 1118) Reports and additional information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Commission maintains an Internet site that contains reports, proxy and information statements, and other... electronic or paper copies of those filings and other reports free of charge upon request. [70 FR 1597, Jan...

  5. 7 CFR 1486.500 - What are the reporting requirements of the program?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the project, both electronically (preferably in PDF format) and in hard copy. (3) Reporting requirements and formats for both quarterly progress reports and final performance reports are specified in the...

  6. 7 CFR 3404.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705-5128.... Information maintained in our electronic reading room can be accessed at http://www.ars.usda.gov/is/foia...

  7. 7 CFR 3404.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705-5128.... Information maintained in our electronic reading room can be accessed at http://www.ars.usda.gov/is/foia...

  8. 7 CFR 3404.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705-5128.... Information maintained in our electronic reading room can be accessed at http://www.ars.usda.gov/is/foia...

  9. 29 CFR 102.142 - Transcripts, recordings or minutes of closed meetings; public availability; retention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., or transcriptions of electronic recordings including the identification of speakers, shall to the... cost of transcription. (c) The agency shall maintain a complete verbatim copy of the transcript, a...

  10. 29 CFR 102.142 - Transcripts, recordings or minutes of closed meetings; public availability; retention.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., or transcriptions of electronic recordings including the identification of speakers, shall to the... cost of transcription. (c) The agency shall maintain a complete verbatim copy of the transcript, a...

  11. Observation of coherent Smith-Purcell and transition radiation driven by single bunch and micro-bunched electron beams

    NASA Astrophysics Data System (ADS)

    Liang, Yifan; Du, Yingchao; Su, Xiaolu; Wang, Dan; Yan, Lixin; Tian, Qili; Zhou, Zheng; Wang, Dong; Huang, Wenhui; Gai, Wei; Tang, Chuanxiang; Konoplev, I. V.; Zhang, H.; Doucas, G.

    2018-01-01

    Generation of coherent Smith-Purcell (cSPr) and transition/diffraction radiation using a single bunch or a pre-modulated relativistic electron beam is one of the growing research areas aiming at the development of radiation sources and beam diagnostics for accelerators. We report the results of comparative experimental studies of terahertz radiation generation by an electron bunch and micro-bunched electron beams and the spectral properties of the coherent transition and SP radiation. The properties of cSPr spectra are investigated and discussed, and excitations of the fundamental and second harmonics of cSPr and their dependence on the beam-grating separation are shown. The experimental and theoretical results are compared, and good agreement is demonstrated.

  12. High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases.

    PubMed

    Ricciotti, Robert W; Baraff, Aaron J; Jour, George; Kyriss, McKenna; Wu, Yu; Liu, Yuhua; Li, Shao-Chun; Hoch, Benjamin; Liu, Yajuan J

    2017-12-01

    Dedifferentiated liposarcoma (DDLS) is characterized at the molecular level by amplification of genes within 12q13-15 including MDM2 and CDK4. However, other than FNCLCC grade, prognostic markers are limited. We aim to identify molecular prognostic markers for DDLS to help risk stratify patients. To this end, we studied 49 cases of DDLS in our institutional archives and performed cytogenomic microarray analysis on 47 cases. Gene copy numbers for 12 loci were evaluated and correlated with outcome data retrieved from our institutional electronic medical records. Using cut point analysis and comparison of Kaplan-Meier survival curves by log rank tests, high amplification levels of MDM2 (>38 copies) and CDK4 (>30 copies) correlated with decreased disease free survival (DFS) (P = .0168 and 0.0169 respectively) and disease specific survival (DSS) (P = .0082 and 0.0140 respectively). Additionally, MDM2 and CDK4 showed evidence of a synergistic effect so that each additional copy of one enhances the effect on prognosis of each additional copy of the other for decreased DFS (P = .0227, 0.1% hazard). High amplification of JUN (>16 copies) also correlated with decreased DFS (P = .0217), but not DSS. The presence of copy number alteration at 3q29 correlated with decreased DSS (P = .0192). The presence of >10 mitoses per 10 high power fields and FNCLCC grade 3 also correlated with decreased DFS (P = .0310 and 0.0254 respectively). MDM2 and CDK4 gene amplification levels, along with JUN amplification and copy alterations at 3q29, can be utilized for predicting outcome in patients with DDLS. Published by Elsevier Inc.

  13. 150K - 200K miniature pulse tube cooler for micro satellites

    NASA Astrophysics Data System (ADS)

    Chassaing, Clément; Butterworth, James; Aigouy, Gérald; Daniel, Christophe; Crespin, Maurice; Duvivier, Eric

    2014-01-01

    Air Liquide is working with the CNES and Steel électronique in 2013 to design, manufacture and test a Miniature Pulse Tube Cooler (MPTC) to cool infrared detectors for micro-satellite missions. The cooler will be particularly adapted to the needs of the CNES MICROCARB mission to study atmospheric Carbon Dioxide which presents absorption lines in the thermal near infrared, at 1.6 μm and 2.0 μm. The required cooler temperature is from 150 to 200K with cooling power between 1 and 3 watts. The overall electrical power budget including electronics is less than 20W with a 288-300K rejection temperature. Particular attention is therefore paid to optimizing overall system efficiency. The active micro vibration reduction system and thermal control systems already developed for the Air Liquide Large Pulse Tube Cooler (LPTC) are currently being implemented into a new high efficiency electronic architecture. The presented work concerns the new cold finger and electronic design. The cooler uses the compressor already developed for the 80K Miniature Pulse Tube Cryocooler. This Pulse Tube Cooler addresses the requirements of space missions where extended continuous operating life time (>5 years), low mass and low micro vibration levels are critical.

  14. Design, fabrication, and evaluation of on-chip micro-supercapacitors

    NASA Astrophysics Data System (ADS)

    Beidaghi, Majid; Chen, Wei; Wang, Chunlei

    2011-06-01

    Development of miniaturized electronic systems has stimulated the demand for miniaturized power sources that can be integrated into such systems. Among the different micro power sources micro electrochemical energy storage and conversion devices are particularly attractive because of their high efficiency and relatively high energy density. Electrochemical micro-capacitors or micro-supercapacitors offer higher power density compared to micro-batteries and micro-fuel cells. In this paper, development of on-chip micro-supercapacitors based on interdigitated C-MEMS electrode microarrays is introduced. C-MEMS electrodes are employed both as electrode material for electric double layer capacitor (EDLC) or as three dimensional (3D) current collectors of EDLC or pseudo-capacitive materials. Recent advancements in fabrication methods of C-MEMS based micro-supercapacitors are discussed and electrochemical properties of C-MEMS electrodes and it composites are reviewed.

  15. Micro-emulsion-assisted synthesis of ZnS nanospheres and their photocatalytic activity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li Yao; He Xiaoyan; Cao Minhua

    2008-11-03

    ZnS nanospheres with rough surface were synthesized by using a micro-emulsion-assisted solvothemal process. The molar ratio of [water]/[surfactant] played an important role in controlling the size of the ZnS nanospheres. X-ray powder diffraction (XRD), transmission electron microscopy (TEM), field emission-scanning electron microscope (FE-SEM), and selected area electron diffraction (SAED) were used for the characterization of the resulting ZnS nanospheres. A possible formation mechanism was proposed. These ZnS nanospheres exhibited a good photocatalytic activity for degradation of an aqueous p-nitrophenol solution and the total organic carbon (TOC) of the degradation product has also been investigated.

  16. Evaluating Maintenance Performance: Test Administrator's Manual and Test Subject's Instructions for Criterion Referenced Job Task Performance Tests for Electronic Maintenance. Final Report.

    ERIC Educational Resources Information Center

    Shriver, Edgar L.; And Others

    This document furnishes a complete copy of the Test Subject's Instructions and the Test Administrator's Handbook for a battery of criterion referenced Job Task Performance Tests (JTPT) for electronic maintenance. General information is provided on soldering, Radar Set AN/APN-147(v), Radar Set Special Equipment, Radar Set Bench Test Set-Up, and…

  17. Improved efficiency of ZnO hierarchical particle based dye sensitized solar cell by incorporating thin passivation layer in photo-anode

    NASA Astrophysics Data System (ADS)

    Das, Priyanka; Mondal, Biswanath; Mukherjee, Kalisadhan

    2018-01-01

    Present article describes the DSSC performances of photo-anodes prepared using hydrothermal route derived ZnO particles having dissimilar morphologies i.e. simple micro-rod and nano-tips decorated micro-rod. The surface of nano-tips decorated micro-rod is uneven and patterned which facilitate more dye adsorption and better scattering of the incident light resulting superior photo-conversion efficiency (PCE) ( η 1.09%) than micro-rod ZnO ( η 0.86%). To further improve the efficiency of nano-tips decorated micro-rod ZnO based DSSC, thin passivation layer of ZnO is introduced in the corresponding photo-anode and a higher PCE ( η 1.29%) is achieved. The compact thin passivation layer here expedites the transportation of photo-excited electrons, restricts the undesired recombination reactions and prevents the direct contact of electrolyte with conducting substrates. Attempt is made to understand the effect of passivation layer on the transportation kinetics of photo-excited electrons by analyzing the electrochemical impedance spectra of the developed cells.

  18. In situ thermomechanical testing methods for micro/nano-scale materials.

    PubMed

    Kang, Wonmo; Merrill, Marriner; Wheeler, Jeffrey M

    2017-02-23

    The advance of micro/nanotechnology in energy-harvesting, micropower, electronic devices, and transducers for automobile and aerospace applications has led to the need for accurate thermomechanical characterization of micro/nano-scale materials to ensure their reliability and performance. This persistent need has driven various efforts to develop innovative experimental techniques that overcome the critical challenges associated with precise mechanical and thermal control of micro/nano-scale specimens during material characterization. Here we review recent progress in the development of thermomechanical testing methods from miniaturized versions of conventional macroscopic test systems to the current state of the art of in situ uniaxial testing capabilities in electron microscopes utilizing either indentation-based microcompression or integrated microsystems. We discuss the major advantages/disadvantages of these methods with respect to specimen size, range of temperature control, ease of experimentation and resolution of the measurements. We also identify key challenges in each method. Finally, we summarize some of the important discoveries that have been made using in situ thermomechanical testing and the exciting research opportunities still to come in micro/nano-scale materials.

  19. Cryo-electron microscopy study of bacteriophage T4 displaying anthrax toxin proteins

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fokine, Andrei; Bowman, Valorie D.; Battisti, Anthony J.

    2007-10-25

    The bacteriophage T4 capsid contains two accessory surface proteins, the small outer capsid protein (Soc, 870 copies) and the highly antigenic outer capsid protein (Hoc, 155 copies). As these are dispensable for capsid formation, they can be used for displaying proteins and macromolecular complexes on the T4 capsid surface. Anthrax toxin components were attached to the T4 capsid as a fusion protein of the N-terminal domain of the anthrax lethal factor (LFn) with Soc. The LFn-Soc fusion protein was complexed in vitro with Hoc{sup -}Soc{sup -}T4 phage. Subsequently, cleaved anthrax protective antigen heptamers (PA63){sub 7} were attached to the exposedmore » LFn domains. A cryo-electron microscopy study of the decorated T4 particles shows the complex of PA63 heptamers with LFn-Soc on the phage surface. Although the cryo-electron microscopy reconstruction is unable to differentiate on its own between different proposed models of the anthrax toxin, the density is consistent with a model that had predicted the orientation and position of three LFn molecules bound to one PA63 heptamer.« less

  20. Can electronic medical images replace hard-copy film? Defining and testing the equivalence of diagnostic tests.

    PubMed

    Obuchowski, N A

    2001-10-15

    Electronic medical images are an efficient and convenient format in which to display, store and transmit radiographic information. Before electronic images can be used routinely to screen and diagnose patients, however, it must be shown that readers have the same diagnostic performance with this new format as traditional hard-copy film. Currently, there exist no suitable definitions of diagnostic equivalence. In this paper we propose two criteria for diagnostic equivalence. The first criterion ('population equivalence') considers the variability between and within readers, as well as the mean reader performance. This criterion is useful for most applications. The second criterion ('individual equivalence') involves a comparison of the test results for individual patients and is necessary when patients are followed radiographically over time. We present methods for testing both individual and population equivalence. The properties of the proposed methods are assessed in a Monte Carlo simulation study. Data from a mammography screening study is used to illustrate the proposed methods and compare them with results from more conventional methods of assessing equivalence and inter-procedure agreement. Copyright 2001 John Wiley & Sons, Ltd.

  1. MEMS based pumped liquid cooling systems for micro/nano spacecraft thermal control

    NASA Technical Reports Server (NTRS)

    Birur, G. C.; Shakkottai, P.; Sur, T. W.

    2000-01-01

    The electronic and other payload power densities in future micro/nano spacecraft are expected to exceed 25 Watts/cm(sup 2) and require advanced thermal control concepts and technologies to keep their payload within allowable temperature limits. This paper presents background on the need for pumped liquid cooling systems for future micro/nano spacecraft and results from this ongoing experimental investigation.

  2. 48 CFR 204.604 - Responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 204.604 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Reporting 204.604 Responsibilities. (1) The... in the associated Government contract file instead of including a paper copy of the electronically...

  3. 48 CFR 204.604 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Section 204.604 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Reporting 204.604 Responsibilities. (1) The... in the associated Government contract file instead of including a paper copy of the electronically...

  4. 48 CFR 204.604 - Responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Section 204.604 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Reporting 204.604 Responsibilities. (1) The... in the associated Government contract file instead of including a paper copy of the electronically...

  5. 48 CFR 204.604 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Section 204.604 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Reporting 204.604 Responsibilities. (1) The... in the associated Government contract file instead of including a paper copy of the electronically...

  6. 48 CFR 204.604 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Section 204.604 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Reporting 204.604 Responsibilities. (1) The... in the associated Government contract file instead of including a paper copy of the electronically...

  7. 7 CFR 3701.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  8. 7 CFR 3404.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705-5128.... Information maintained in our electronic reading room can be accessed at http://www.ars.usda.gov/is/foia...

  9. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  10. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  11. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  12. 7 CFR 3701.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  13. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  14. 7 CFR 3701.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  15. 7 CFR 3701.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  16. 7 CFR 3601.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  17. 7 CFR 3701.2 - Public inspection, copying, and indexing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...: Information Staff, ARS, REE, USDA, Room 1-2248, Mail Stop 5128, 5601 Sunnyside Avenue, Beltsville, MD 20705... 4:30 p.m. Information maintained in our electronic reading room can be accessed at http://www.ars...

  18. 75 FR 1296 - Small Business Size Regulations; 8(a) Business Development/Small Disadvantaged Business Status...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... program and small business size standards. In conjunction with the public meetings SBA is conducting... supplements his or her testimony. Electronic or digitized copies are encouraged. In conjunction with the...

  19. 78 FR 16527 - Alaska Native Claims Selection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... electronic means, such as facsimile or email, will not be accepted as timely filed. ADDRESSES: A copy of the... call the Federal Information Relay Service (FIRS) at 1-800-877-8339 to contact the BLM during normal...

  20. 75 FR 70617 - Practices and Procedures, Board Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... provisions of 5 U.S.C. 552b(c). Copies of transcripts or minutes, or transcriptions of electronic recordings... furnished to any person, subject to the payment of duplication costs or the actual cost of transcription. (3...

  1. Comparison of dislocation content measured with transmission electron microscopy and micro-Laue diffraction based streak analysis

    DOE PAGES

    Zhang, C.; Balachandran, S.; Eisenlohr, P.; ...

    2017-10-04

    The subsurface dislocation content in a Ti-5Al-2.5Sn (wt%) uniaxial tension sample deformed at ambient temperature was characterized by peak streak analysis of micro-Laue diffraction patterns collected non-destructively by differential aperture X-raymicroscopy, and with focused ion beam transmission electron microscopy of material in the same volume. This comparison reveals that micro-Laue diffraction streak analysis based on an edge dislocation assumption can accurately identify the dominant dislocation slip system history (Burgers vector and plane observed by TEM), despite the fact that dislocations have predominantly screw character. As a result, other dislocations identified by TEM were not convincingly discernible from the peak streakmore » analysis.« less

  2. A high-gain, low ion-backflow double micro-mesh gaseous structure for single electron detection

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiyong; Qi, Binbin; Liu, Chengming; Feng, Jianxin; Liu, Jianbei; Shao, Ming; Zhou, Yi; Hong, Daojin; Lv, You; Song, Guofeng; Wang, Xu; You, Wenhao

    2018-05-01

    Application of micro-pattern gaseous detectors to gaseous photomultiplier tubes has been widely investigated over the past two decades. In this paper, we present a double micro-mesh gaseous structure that has been designed and fabricated for this application. Tests with X-rays and UV laser light indicate that this structure exhibits an excellent gas gain of > 7 × 104 and good energy resolution of 19% (full width at half maximum) for 5.9 keV X-rays. The gas gain can reach up to 106 for single electrons while maintaining a very low ion-backflow ratio down to 0.0005. This structure has good potential for other applications requiring a very low level of ion backflow.

  3. Sensing of single electrons using micro and nano technologies: a review

    NASA Astrophysics Data System (ADS)

    Jalil, Jubayer; Zhu, Yong; Ekanayake, Chandima; Ruan, Yong

    2017-04-01

    During the last three decades, the remarkable dynamic features of microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS), and advances in solid-state electronics hold much potential for the fabrication of extremely sensitive charge sensors. These sensors have a broad range of applications, such as those involving the measurement of ionization radiation, detection of bio-analyte and aerosol particles, mass spectrometry, scanning tunneling microscopy, and quantum computation. Designing charge sensors (also known as charge electrometers) for electrometry is deemed significant because of the sensitivity and resolution issues in the range of micro- and nano-scales. This article reviews the development of state-of-the-art micro- and nano-charge sensors, and discusses their technological challenges for practical implementation.

  4. Comparison of dislocation content measured with transmission electron microscopy and micro-Laue diffraction based streak analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, C.; Balachandran, S.; Eisenlohr, P.

    The subsurface dislocation content in a Ti-5Al-2.5Sn (wt%) uniaxial tension sample deformed at ambient temperature was characterized by peak streak analysis of micro-Laue diffraction patterns collected non-destructively by differential aperture X-raymicroscopy, and with focused ion beam transmission electron microscopy of material in the same volume. This comparison reveals that micro-Laue diffraction streak analysis based on an edge dislocation assumption can accurately identify the dominant dislocation slip system history (Burgers vector and plane observed by TEM), despite the fact that dislocations have predominantly screw character. As a result, other dislocations identified by TEM were not convincingly discernible from the peak streakmore » analysis.« less

  5. Procurement of novel microanalysis equipment for construction materials.

    DOT National Transportation Integrated Search

    2012-02-01

    The equipment procured (i.e. an Orbis micro X-ray Fluorescence (MXRF) and an APSEX personal Scanning Electron Microscope (PSEM)) is part of the next generation of micro analytical equipment. These tools have the ability to make large volumes of...

  6. PCR-based Analysis of Microbial Communities in Extreme Environment: Results from EuroGeoMars MDRS campaign

    NASA Astrophysics Data System (ADS)

    Thiel, C.; Wills, D.; Foing, B.; Wadham, J.; Cullen, D.; van Sluis, C.

    2009-04-01

    Deoxyribonucleic acid (DNA) is found in almost all living organisms. The main function of DNA molecules is the long-term storage of genetic information.They are passed on from generation to generation as the hereditary material. This molecular structure is often compared to a genetic blueprint, a fingerprint, which is unique for each organism and can therefore be used as a mean of identification. In 1984 a revolutionary technique called polymerase chain reaction (PCR) was established, able to amplify a single or few copies of DNA molecules across several orders of magnitude, generating millions of copies of the original DNA fragment. PCR is nowadays a common technique used in medical and biological research laboratories for a large variety of applications like functional analysis of genes, DNA-based phylogeny, diagnosis of hereditary diseases, detection and diagnosis of infectious diseases, and identification of genetic fingerprints. This powerful tool gives us the opportunity to investigate, if there is or was life on Mars since DNA fragments are highly stable what allows not only amplification from living organisms but also from samples with an age of several thousand years. If we assume that micro-organisms were exchanged between Mars and Earth via meteorites, it is imaginable that Martian life might also be based on DNA as carrier of genetic information. Therefore our goal is to establish a routine for detection of DNA from micro-organisms based on the effective but also robust and simple PCR technique, demonstrated during the EuroGeoMars simulation campaign at Mars Desert Research Station (MDRS). We have already analysed some MDRS soil samples at ESTEC ExoGeoLab facility. During the MDRS simulation we will show that it is possible to establish a minimal molecular biology lab in the habitat for an immediate on site analysis by PCR after sample collection. Samples will be taken from different locations and soil depths. The sample analysis will start immediately after returning to the habitat and will be finished during the following days. DNA will be isolated from micro-organisms by Powersoil DNA isolation kit and serves as template for PCR using oligonucleotides specific for ribosomal DNA to identify representatives of the different groups of micro-organisms: archaea, bacteria and eukaryotes. PCR products will be analysed by agarose gel electrophoresis and documented via UV-trans-illuminator and digital camera.

  7. Modeling and control for micro and nano manipulation

    NASA Astrophysics Data System (ADS)

    Wejinya, Uchechukwu C.

    Manipulation of micro and nano entities implies the movement of micro and nano entities from an initial position (location) to the desire position (location). This operation is not only necessary, but a required task with great precision. The tools needed for the manipulation needs to be chosen properly because the capabilities of the human hand are very restricted. Smart micro and nano manipulation are becoming of great interest in many applications including medicine and industry. In industry, high precision manipulation systems are especially needed for mass production of both micro and nano systems which consist of different component in respective scales. The transition from assembling and manipulating micro and nano entities manually to mass products with high quality is only attainable by automated assembly and manipulation systems. An example is the testing of integrated circuits which can be carried out by exchanging the manipulation tool by an electric probe. Furthermore, in medical research it is customary to pick up a single cell (human, plant, or animal), and carry it to another device which is used to further analyze the cell. Consequently, the cell of interest has to be separated from the other cells and picked up using the appropriate micro/nano tool. Hence it becomes absolutely necessary that the appropriate tool be used for specific micro or nano entity manipulation and assembly. In this research, we focus on developing micro tool for manipulating micro and nano entities in liquid environment using a micro fluidic end effector system with in-situ Polyvinylidene Fluoride (PVDF) sensing. The microfluidic end effector system consists of a DC micro-diaphragm pump and compressor, one region of flexible latex tube, a Polyvinylidene Fluoride (PVDF) sensor for in-situ measurement of micro drag force, and a micro pipette. The micro pipette of the novel microfluidic end effector system has an internal diameter (ID) smaller than 20mum used for microfluidic handling and deposition of micro and nano entities such as carbon nanotubes (CNT), DNA, and for droplet control. The novel microfluidic end effector system with force sensing can significantly improve the success rate for handling/depositing micro/nano entities in the case of carbon nanotubes between micro electrodes. The design, calibration, and experimental implementation of the novel microfluidic end effector is carried out in this research. The experimental results show the success rate for carbon nanotube(s) deposition between micro electrodes can reach close to 80%. Furthermore, carbon nanotubes are of particular interest because they are good candidates for many electronics and sensing applications. The interests in using carbon nanotubes to manufacture electronics and sensors have increased in recent years because of the increase need for making electronics smaller, and their excellent electrical and mechanical properties. These potentials can be achieved if CNTs with semiconducting and metallic band structure can be successfully deposited and separated. The use of dielectrophoresis (DEP) has been established as a course towards the efficient deposition and separation of metallic carbon nanotubes from semiconducting carbon nanotubes. For this reason, this research presents a new mathematical model for dielectrophoresis and electrorotation of carbon nanotubes. Simulation results are presented in this research to validate the developed model. The combination of both the micro robotic manipulation system and the atomic force microscopy (AFM) based nano-robotic system will provide a powerful tool for micro and nano manipulation. Additional applications of this research are endless considering the rapid development of micro and nano technologies.

  8. Fixture-abutment connection surface and micro-gap measurements by 3D micro-tomographic technique analysis.

    PubMed

    Meleo, Deborah; Baggi, Luigi; Di Girolamo, Michele; Di Carlo, Fabio; Pecci, Raffaella; Bedini, Rossella

    2012-01-01

    X-ray micro-tomography (micro-CT) is a miniaturized form of conventional computed axial tomography (CAT) able to investigate small radio-opaque objects at a-few-microns high resolution, in a non-destructive, non-invasive, and tri-dimensional way. Compared to traditional optical and electron microscopy techniques, which provide two-dimensional images, this innovative investigation technology enables a sample tri-dimensional analysis without cutting, coating or exposing the object to any particular chemical treatment. X-ray micro-tomography matches ideal 3D microscopy features: the possibility of investigating an object in natural conditions and without any preparation or alteration; non-invasive, non-destructive, and sufficiently magnified 3D reconstruction; reliable measurement of numeric data of the internal structure (morphology, structure and ultra-structure). Hence, this technique has multi-fold applications in a wide range of fields, not only in medical and odontostomatologic areas, but also in biomedical engineering, materials science, biology, electronics, geology, archaeology, oil industry, and semi-conductors industry. This study shows possible applications of micro-CT in dental implantology to analyze 3D micro-features of dental implant to abutment interface. Indeed, implant-abutment misfit is known to increase mechanical stress on connection structures and surrounding bone tissue. This condition may cause not only screw preload loss or screw fracture, but also biological issues in peri-implant tissues.

  9. Electron current extraction from radio frequency excited micro-dielectric barrier discharges

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Jun-Chieh; Kushner, Mark J.; Leoni, Napoleon

    Micro dielectric barrier discharges (mDBDs) consist of micro-plasma devices (10-100 {mu}m diameter) in which the electrodes are fully or partially covered by dielectrics, and often operate at atmospheric pressure driven with radio frequency (rf) waveforms. In certain applications, it may be desirable to extract electron current out of the mDBD plasma, which necessitates a third electrode. As a result, the physical structure of the m-DBD and the electron emitting properties of its materials are important to its operation. In this paper, results from a two-dimensional computer simulation of current extraction from mDBDs sustained in atmospheric pressure N{sub 2} will bemore » discussed. The mDBDs are sandwich structures with an opening of tens-of-microns excited with rf voltage waveforms of up to 25 MHz. Following avalanche by electron impact ionization in the mDBD cavity, the plasma can be expelled from the cavity towards the extraction electrode during the part of the rf cycle when the extraction electrode appears anodic. The electron current extraction can be enhanced by biasing this electrode. The charge collection can be controlled by choice of rf frequency, rf driving voltage, and permittivity of the dielectric barrier.« less

  10. Sulfur-based autotrophic denitrification from the micro-polluted water.

    PubMed

    Zhou, Weili; Liu, Xu; Dong, Xiaojing; Wang, Zheng; Yuan, Ying; Wang, Hui; He, Shengbing

    2016-06-01

    Eutrophication caused by high concentrations of nutrients is a huge problem for many natural lakes and reservoirs. Removing the nitrogen contamination from the low C/N water body has become an urgent need. Autotrophic denitrification with the sulfur compound as electron donor was investigated in the biofilter reactors. Through the lab-scale experiment, it was found that different sulfur compounds and different carriers caused very different treatment performances. Thiosulfate was selected to be the best electron donor and ceramsite was chosen as the suitable carrier due to the good denitrification efficiency, low cost and the good resistibility against the high hydraulic loads. Later the optimum running parameters of the process were determined. Then the pilot-scale experiment was carried out with the real micro-polluted water from the West Lake, China. The results indicated that the autotrophic denitrification with thiosulfate as electron donor was feasible and applicable for the micro-polluted lake water. Copyright © 2016. Published by Elsevier B.V.

  11. High resolution rare-earth elements analyses of natural apatite and its application in geo-sciences: Combined micro-PIXE, quantitative CL spectroscopy and electron spin resonance analyses

    NASA Astrophysics Data System (ADS)

    Habermann, D.; Götte, T.; Meijer, J.; Stephan, A.; Richter, D. K.; Niklas, J. R.

    2000-03-01

    The rare-earth element (REE) distribution in natural apatite is analysed by micro-PIXE, cathodoluminescence (CL) microscopy and spectroscopy and electron spin resonance (ESR) spectroscopy. The micro-PIXE analyses of an apatite crystal from Cerro de Mercado (Mexico) and the summary of 20 analyses of six francolite (conodonts of Triassic age) samples indicate that most of the REEs are enriched in apatite and francolite comparative to average shale standard (NASC). The analyses of fossil francolite revealing the REE-distribution not to be in balance with the REE-distribution of seawater and fish bone debris. Strong inhomogenous lateral REE-distribution in fossil conodont material is shown by CL-mapping and most probably not being a vital effect. Therefore, the resulting REE-signal from fossil francolite is the sum of vital and post-mortem incorporation. The necessary charge compensation for the substitution of divalent Ca by trivalent REE being done by different kind of electron defects and defect ions.

  12. ANNOUNCEMENT: To the readers of Kvantovaya Elektronika

    NASA Astrophysics Data System (ADS)

    1994-06-01

    The Radio i Svyaz' Press is preparing to publish several books on a number of topics in quantum electronics. These books are described below. They are included in the Federal Target Programme for the publication of books in Russia in 1994. In accordance with the Programme, the books are supported financially by the State to pay for the cost of paper and printing. Since at present the question of finance is very problematic and the actual cost of each of these books can be between 12 and 20 thousand roubles per copy, if the number of copies printed is 800-1500 the retail price of each copy would be between 15 and 25 thousand roubles. Consequently, if for any reason we do not receive financial support from the Federal Programme or if we do not receive guaranteed orders from readers, bearing in mind the real retail price, the Press will be unable to publish these books. Guaranteed orders are accepted from organisations and from individuals. The price includes postage on a cash-on-delivery basis if there is a guaranteed print order of 800-1500 copies of each book.

  13. 32 CFR 651.4 - Responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) and Materiel Fielding Plans, Demilitarization/Disposal Plans, system engineering reviews/Integrated... (including NEPA) into the system acquisition strategy, milestone review planning, system engineering, and... copy and make this guidance available on the World Wide Web (WWW) and other electronic means. (13...

  14. 77 FR 38280 - Final Test Guidelines; 810 Series 2000 Product Performance; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... available either electronically through http://www.regulations.gov or in hard copy at the OPP Docket in the...) and revised based on comments received from industry. In addition, formatting changes to incorporate...

  15. 75 FR 25204 - Endangered and Threatened Species; Recovery Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... can obtain an electronic copy (i.e., CD-ROM) from Andrea Berry by calling (866) 300-2948 or by e-mailing a request to [email protected] with the subject line ``CD-ROM Request for CCC coho salmon...

  16. 30 CFR 590.4 - How do I file an appeal?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Notice of Appeal. (1) You must pay electronically through Pay.gov at: https://www.pay.gov/paygov/, and you must include a copy of the Pay.gov confirmation receipt page with your Notice of Appeal. (2) You...

  17. 30 CFR 590.4 - How do I file an appeal?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Notice of Appeal. (1) You must pay electronically through Pay.gov at: https://www.pay.gov/paygov/, and you must include a copy of the Pay.gov confirmation receipt page with your Notice of Appeal. (2) You...

  18. 30 CFR 290.4 - How do I file an appeal?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Appeal. (1) You must pay electronically through Pay.gov at: https://www.pay.gov/paygov/, and you must include a copy of the Pay.gov confirmation receipt page with your Notice of Appeal. (2) You cannot...

  19. 77 FR 25749 - Certain Drill Bits and Products Containing Same; Notice of Receipt of Complaint; Solicitation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ...., Peru; Christensen Chile S.A., Chile; Diamantina Christensen Trading Inc., Panama; and Intermountain... document electronically on or before the deadlines stated above and submit 8 true paper copies to the...

  20. Micro-laser

    DOEpatents

    Hutchinson, Donald P.; Richards, Roger K.

    2003-07-22

    A micro-laser is disclosed which includes a waveguide, a first and a second subwavelength resonant grating in the waveguide, and at least one photonic band gap resonant structure (PBG) in the waveguide and at least one amplifying medium in the waveguide. PBG features are positioned between the first and second subwavelength resonant gratings and allow introduction of amplifying mediums into the highly resonant guided micro-laser microcavity. The micro-laser may be positioned on a die of a bulk substrate material with one or more electronic and optical devices and may be communicably connected to the same. A method for fabricating a micro-laser is disclosed. A method for tuning the micro-laser is also disclosed. The micro-laser may be used as an optical regenerator, or a light source for data transfer or for optical computing.

Some links on this page may take you to non-federal websites. Their policies may differ from this site.
Top