Multicenter Evaluation of Epidemiological Typing of Methicillin-Resistant Staphylococcus aureus Strains by Repetitive-Element PCR Analysis

PubMed Central

Deplano, Ariane; Schuermans, Annette; Van Eldere, Johan; Witte, Wolfgang; Meugnier, Hèléne; Etienne, Jerome; Grundmann, Hajo; Jonas, Daniel; Noordhoek, Gerda T.; Dijkstra, Jolanda; van Belkum, Alex; van Leeuwen, Willem; Tassios, Panayotis T.; Legakis, Nicholas J.; van der Zee, Anneke; Bergmans, Anneke; Blanc, Dominique S.; Tenover, Fred C.; Cookson, Barry C.; O'Neil, Gael; Struelens, Marc J.

2000-01-01

Rapid and efficient epidemiologic typing systems would be useful to monitor transmission of methicillin-resistant Staphylococcus aureus (MRSA) at both local and interregional levels. To evaluate the intralaboratory performance and interlaboratory reproducibility of three recently developed repeat-element PCR (rep-PCR) methods for the typing of MRSA, 50 MRSA strains characterized by pulsed-field gel electrophoresis (PFGE) (SmaI) analysis and epidemiological data were blindly typed by inter-IS256, 16S-23S ribosomal DNA (rDNA), and MP3 PCR in 12 laboratories in eight countries using standard reagents and protocols. Performance of typing was defined by reproducibility (R), discriminatory power (D), and agreement with PFGE analysis. Interlaboratory reproducibility of pattern and type classification was assessed visually and using gel analysis software. Each typing method showed a different performance level in each center. In the center performing best with each method, inter-IS256 PCR typing achieved R = 100% and D = 100%; 16S-23S rDNA PCR, R = 100% and D = 82%; and MP3 PCR, R = 80% and D = 83%. Concordance between rep-PCR type and PFGE type ranged by center: 70 to 90% for inter-IS256 PCR, 44 to 57% for 16S-23S rDNA PCR, and 53 to 54% for MP3 PCR analysis. In conclusion, the performance of inter-IS256 PCR typing was similar to that of PFGE analysis in some but not all centers, whereas other rep-PCR protocols showed lower discrimination and intralaboratory reproducibility. None of these assays, however, was sufficiently reproducible for interlaboratory exchange of data. PMID:11015358

76 FR 256 - Informed Consent Elements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-04

... societies, trade organizations representing clinical research organizations, drug and device sponsors, blood banks, clinical research organizations, research hospitals, medical device manufacturers, nonprofit... Administration Amendments Act of 2007 (FDAAA) and is designed to promote transparency of clinical research to...

49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

49 CFR 240.105 - Criteria for selection of designated supervisors of locomotive engineers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of locomotive engineers. 240.105 Section 240.105 Transportation Other Regulations Relating to... CERTIFICATION OF LOCOMOTIVE ENGINEERS Component Elements of the Certification Process § 240.105 Criteria for selection of designated supervisors of locomotive engineers. (a) Each railroad's program shall include...

Advanced Wavefront Sensor Concepts.

DTIC Science & Technology

1981-01-01

internal optics (a) Characteristics (see Figure 47) - Intensification with a 256 element linear self scanned diode array - Optical input; lenticular ...34 diameter - Lenticular array input to fiber optics which spread out to tubes - Photon counting for low noise fac- tor (b) Pe r fo rmance - Bialkali...problem in making the lenslet arrays in the pupil divider rectangular. The last optical elements are the lenticular lens arrays. In this group, the first

75 FR 81337 - Interim Final Regulation Deferring the Reporting Date for Certain Data Elements Required Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

... Meat processing facilities. 311411 Frozen fruit, juice, and vegetable manufacturing facilities. 311421... volume conversion factor. Y 98.256(m)(3) Only total quantity of crude oil plus the quantity of...

Efficient Parallel Formulations of Hierarchical Methods and Their Applications

NASA Astrophysics Data System (ADS)

Grama, Ananth Y.

1996-01-01

Hierarchical methods such as the Fast Multipole Method (FMM) and Barnes-Hut (BH) are used for rapid evaluation of potential (gravitational, electrostatic) fields in particle systems. They are also used for solving integral equations using boundary element methods. The linear systems arising from these methods are dense and are solved iteratively. Hierarchical methods reduce the complexity of the core matrix-vector product from O(n^2) to O(n log n) and the memory requirement from O(n^2) to O(n). We have developed highly scalable parallel formulations of a hybrid FMM/BH method that are capable of handling arbitrarily irregular distributions. We apply these formulations to astrophysical simulations of Plummer and Gaussian galaxies. We have used our parallel formulations to solve the integral form of the Laplace equation. We show that our parallel hierarchical mat-vecs yield high efficiency and overall performance even on relatively small problems. A problem containing approximately 200K nodes takes under a second to compute on 256 processors and yet yields over 85% efficiency. The efficiency and raw performance is expected to increase for bigger problems. For the 200K node problem, our code delivers about 5 GFLOPS of performance on a 256 processor T3D. This is impressive considering the fact that the problem has floating point divides and roots, and very little locality resulting in poor cache performance. A dense matrix-vector product of the same dimensions would require about 0.5 TeraBytes of memory and about 770 TeraFLOPS of computing speed. Clearly, if the loss in accuracy resulting from the use of hierarchical methods is acceptable, our code yields significant savings in time and memory. We also study the convergence of a GMRES solver built around this mat-vec. We accelerate the convergence of the solver using three preconditioning techniques: diagonal scaling, block-diagonal preconditioning, and inner-outer preconditioning. We study the performance and parallel efficiency of these preconditioned solvers. Using this solver, we solve dense linear systems with hundreds of thousands of unknowns. Solving a 105K unknown problem takes about 10 minutes on a 64 processor T3D. Until very recently, boundary element problems of this magnitude could not even be generated, let alone solved.

Qualification of M256 Breechblock Repair Procedure

DTIC Science & Technology

1994-03-01

Percent) Element Chemistry Carbon 0.30/0.40 Silicon 0.15/0.35 Manganese 0.40/0.70 Phosphorus 0.015 max Sulfur 0.015 max Aluminum 0.0 15 max Chromium 1.00...Weld Filler Metal, AWS A&28 Class ER120S.1 (Weight Percent) Element Chemistry Carbon 0.07 Silicon 0.35 Sulfur 0.0008 Phosphorus 0.0006 Chromium 0.45...14OS-l) (Weight Percent) Element Chemistry Carbon 0.11 Silicon 0.35 Sulfur 0.0008 Phosphorus 0.0005 Chromium 0.70 Nickel 2.60 Molybdenum 0.90 Manganese

Imaging spectroscopy using embedded diffractive optical arrays

NASA Astrophysics Data System (ADS)

Hinnrichs, Michele; Hinnrichs, Bradford

2017-09-01

Pacific Advanced Technology (PAT) has developed an infrared hyperspectral camera based on diffractive optic arrays. This approach to hyperspectral imaging has been demonstrated in all three infrared bands SWIR, MWIR and LWIR. The hyperspectral optical system has been integrated into the cold-shield of the sensor enabling the small size and weight of this infrared hyperspectral sensor. This new and innovative approach to an infrared hyperspectral imaging spectrometer uses micro-optics that are made up of an area array of diffractive optical elements where each element is tuned to image a different spectral region on a common focal plane array. The lenslet array is embedded in the cold-shield of the sensor and actuated with a miniature piezo-electric motor. This approach enables rapid infrared spectral imaging with multiple spectral images collected and processed simultaneously each frame of the camera. This paper will present our optical mechanical design approach which results in an infrared hyper-spectral imaging system that is small enough for a payload on a small satellite, mini-UAV, commercial quadcopter or man portable. Also, an application of how this spectral imaging technology can easily be used to quantify the mass and volume flow rates of hydrocarbon gases. The diffractive optical elements used in the lenslet array are blazed gratings where each lenslet is tuned for a different spectral bandpass. The lenslets are configured in an area array placed a few millimeters above the focal plane and embedded in the cold-shield to reduce the background signal normally associated with the optics. The detector array is divided into sub-images covered by each lenslet. We have developed various systems using a different number of lenslets in the area array. Depending on the size of the focal plane and the diameter of the lenslet array will determine the number of simultaneous different spectral images collected each frame of the camera. A 2 x 2 lenslet array will image four different spectral images of the scene each frame and when coupled with a 512 x 512 focal plane array will give spatial resolution of 256 x 256 pixel each spectral image. Another system that we developed uses a 4 x 4 lenslet array on a 1024 x 1024 pixel element focal plane array which gives 16 spectral images of 256 x 256 pixel resolution each frame. This system spans the SWIR and MWIR bands with a single optical array and focal plane array.

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

PubMed Central

Zhao, Xiangshan; Gan, Lixia; Pan, Haiyun; Kan, Donghui; Majeski, Michael; Adam, Stephen A; Unterman, Terry G

2004-01-01

FOXO1, a Forkhead transcription factor, is an important target of insulin and growth factor action. Phosphorylation of Thr-24, Ser-256 and Ser-319 promotes nuclear exclusion of FOXO1, yet the mechanisms regulating nuclear/cytoplasmic shuttling of FOXO1 are poorly understood. Previous studies have identified an NLS (nuclear localization signal) in the C-terminal basic region of the DBD (DNA-binding domain), and a leucine-rich, leptomycin-B sensitive NES (nuclear export signal) located further downstream. Here, we find that other elements in the DBD also contribute to nuclear localization, and that multiple mechanisms contribute to nuclear exclusion of FOXO1. Phosphorylation of Ser-319 and a cluster of nearby residues (Ser-322, Ser-325 and Ser-329) functions co-operatively with the nearby NES to promote nuclear exclusion. The N-terminal region of FOXO1 (amino acids 1-149) also is sufficient to promote nuclear exclusion, and does so through multiple mechanisms. Amino acids 1-50 are sufficient to promote nuclear exclusion of green fluorescent protein fusion proteins, and the phosphorylation of Thr-24 is required for this effect. A leucine-rich, leptomycin B-sensitive export signal is also present nearby. Phosphorylated FOXO1 binds 14-3-3 proteins, and co-precipitation studies with tagged proteins indicate that 14-3-3 binding involves co-operative interactions with both Thr-24 and Ser-256. Ser-256 is located in the C-terminal region of the DBD, where 14-3-3 proteins may interfere both with DNA-binding and with nuclear-localization functions. Together, these studies demonstrate that multiple elements contribute to nuclear/cytoplasmic shuttling of FOXO1, and that phosphorylation and 14-3-3 binding regulate the cellular distribution and function of FOXO1 through multiple mechanisms. The presence of these redundant mechanisms supports the concept that the regulation of FOXO1 function plays a critical role in insulin and growth factor action. PMID:14664696

Status of two-color and large format HgCdTe FPA technology at Raytheon Vision Systems

NASA Astrophysics Data System (ADS)

Smith, E. P. G.; Bornfreund, R. E.; Kasai, I.; Pham, L. T.; Patten, E. A.; Peterson, J. M.; Roth, J. A.; Nosho, B. Z.; De Lyon, T. J.; Jensen, J. E.; Bangs, J. W.; Johnson, S. M.; Radford, W. A.

2006-02-01

Raytheon Vision Systems (RVS) is developing two-color and large format single color FPAs fabricated from molecular beam epitaxy (MBE) grown HgCdTe triple layer heterojunction (TLHJ) wafers on CdZnTe substrates and double layer heterojunction (DLHJ) wafers on Si substrates, respectively. MBE material growth development has resulted in scaling TLHJ growth on CdZnTe substrates from 10cm2 to 50cm2, long-wavelength infrared (LWIR) DLHJ growth on 4-inch Si substrates and the first demonstration of mid-wavelength infrared (MWIR) DLHJ growth on 6-inch Si substrates with low defect density (<1000cm -2) and excellent uniformity (composition<0.1%, cut-off wavelength Δcenter-edge<0.1μm). Advanced FPA fabrication techniques such as inductively coupled plasma (ICP) etching are being used to achieve high aspect ratio mesa delineation of individual detector elements with benefits to detector performance. Recent two-color detectors with MWIR and LWIR cut-off wavelengths of 5.5μm and 10.5μm, respectively, exhibit significant improvement in 78K LW performance with >70% quantum efficiency, diffusion limited reverse bias dark currents below 300pA and RA products (zero field-of-view, +150mV bias) in excess of 1×103 Ωcm2. Two-color 20μm unit-cell 1280×720 MWIR/LWIR FPAs with pixel response operability approaching 99% have been produced and high quality simultaneous imaging of the spectral bands has been achieved by mating the FPA to a readout integrated circuit (ROIC) with Time Division Multiplexed Integration (TDMI). Large format mega pixel 20μm unit-cell 2048×2048 and 25μm unit-cell 2560×512 FPAs have been demonstrated using DLHJ HgCdTe growth on Si substrates in the short wavelength infrared (SWIR) and MWIR spectral range. Recent imaging of 30μm unit-cell 256×256 LWIR FPAs with 10.0-10.7μm 78K cut-off wavelength and pixel response operability as high as 99.7% show the potential for extending HgCdTe/Si technology to LWIR wavelengths.

Development and validation of real-time PCR screening methods for detection of cry1A.105 and cry2Ab2 genes in genetically modified organisms.

PubMed

Dinon, Andréia Z; Prins, Theo W; van Dijk, Jeroen P; Arisi, Ana Carolina M; Scholtens, Ingrid M J; Kok, Esther J

2011-05-01

Primers and probes were developed for the element-specific detection of cry1A.105 and cry2Ab2 genes, based on their DNA sequence as present in GM maize MON89034. Cry genes are present in many genetically modified (GM) plants and they are important targets for developing GMO element-specific detection methods. Element-specific methods can be of use to screen for the presence of GMOs in food and feed supply chains. Moreover, a combination of GMO elements may indicate the potential presence of unapproved GMOs (UGMs). Primer-probe combinations were evaluated in terms of specificity, efficiency and limit of detection. Except for specificity, the complete experiment was performed in 9 PCR runs, on 9 different days and by testing 8 DNA concentrations. The results showed a high specificity and efficiency for cry1A.105 and cry2Ab2 detection. The limit of detection was between 0.05 and 0.01 ng DNA per PCR reaction for both assays. These data confirm the applicability of these new primer-probe combinations for element detection that can contribute to the screening for GM and UGM crops in food and feed samples.

48 CFR 2845.105 - Records of Government property.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2845.105 Records of Government property. If departmental elements maintain the Government's official property management records, the contract records may be kept as a...

48 CFR 2845.105 - Records of Government property.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2845.105 Records of Government property. If departmental elements maintain the Government's official property management records, the contract records may be kept as a...

Trace elements contamination and human health risk assessment in drinking water from Shenzhen, China.

PubMed

Lu, Shao-You; Zhang, Hui-Min; Sojinu, Samuel O; Liu, Gui-Hua; Zhang, Jian-Qing; Ni, Hong-Gang

2015-01-01

The levels of seven essential trace elements (Mn, Co, Ni, Cu, Zn, Se, and Mo) and six non-essential trace elements (Cr, As, Cd, Sb, Hg, and Pb) in a total of 89 drinking water samples collected in Shenzhen, China were determined using inductively coupled plasma mass spectrometry (ICP-MS) in the present study. Both the essential and non-essential trace elements were frequently detectable in the different kinds of drinking waters assessed. Remarkable temporal and spatial variations were observed among most of the trace elements in the tap water collected from two tap water treatment plants. Meanwhile, potential human health risk from these non-essential trace elements in the drinking water for local residents was also assessed. The median values of cancer risks associated with exposure to carcinogenic metals via drinking water consumption were estimated to be 6.1 × 10(-7), 2.1 × 10(-8), and 2.5 × 10(-7) for As, Cd, and Cr, respectively; the median values of incremental lifetime for non-cancer risks were estimated to be 6.1 × 10(-6), 4.4 × 10(-5), and 2.2 × 10(-5) for Hg, Pb, and Sb, respectively. The median value of total incremental lifetime health risk induced by the six non-essential trace elements for the population was 3.5 × 10(-5), indicating that the potential health risks from non-carcinogenic trace elements in drinking water also require some attention. Sensitivity analysis indicates that the most important factor for health risk assessment should be the levels of heavy metal in drinking water.

41 CFR 105-62.103 - Access to GSA-originated materials.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administration 62-DOCUMENT SECURITY AND DECLASSIFICATION 62.1-Classified Materials § 105-62.103 Access to GSA..., provided that: (1) A written determination is made by the Administrator of General Services that such... element having classification jurisdiction for such information or material makes a written determination...

Fission in the landscape of heaviest elements: Some recent examples

NASA Astrophysics Data System (ADS)

Khuyagbaatar, J.; Yakushev, A.; Düllmann, Ch. E.; Ackermann, D.; Andersson, L.-L.; Block, M.; Brand, H.; Even, J.; Forsberg, U.; Hartmann, W.; Herzberg, R.-D.; Heßberger, F. P.; Hoffmann, J.; Hübner, A.; Jäger, E.; Jeppsson, J.; Kindler, B.; Kratz, J. V.; Krier, J.; Kurz, N.; Lommel, B.; Maiti, M.; Minami, S.; Rudolph, D.; Runke, J.; Sarmiento, L. G.; Schädel, M.; Schausten, B.; Steiner, J.; Heidenreich, T. Torres De; Uusitalo, J.; Wiehl, N.; Yakusheva, V.

2016-12-01

The fission process still remains a main factor that determines the stability of the atomic nucleus of heaviest elements. Fission half-lives vary over a wide range, 10-19-1024 s. Present experimental techniques for the synthesis of the superheavy elements that usually measure α-decay chains are sensitive only in a limited range of half-lives, often 10-5-103 s. In the past years, measurement techniques for very short-lived and very long-lived nuclei were significantly improved at the gas-filled recoil separator TASCA at GSI Darmstadt. Recently, several experimental studies of fission-related phenomena have successfully been performed. In this paper, results on 254-256Rf and 266Lr are presented and corresponding factors for retarding the fission process are discussed.

Combination of LC/TOF-MS and LC/Ion Trap MS/MS for the Identification of Diphenhydramine in Sediment Samples

USGS Publications Warehouse

Ferrer, I.; Heine, C.E.; Thurman, E.M.

2004-01-01

Diphenhydramine (Benadryl) is a popular over-the-counter antihistaminic medication used for the treatment of allergies. After consumption, excretion, and subsequent discharge from wastewater treatment plants, it is possible that diphenhydramine will be found in environmental sediments due to its hydrophobicity (log P = 3.27). This work describes a methodology for the first unequivocal determination of diphenhydramine bound to environmental sediments. The drug is removed from the sediments by accelerated solvent extraction and then analyzed by liquid chromatography with a time-of-flight mass spectrometer and an ion trap mass spectrometer. This combination of techniques provided unequivocal identification and confirmation of diphenhydramine in two sediment samples. The accurate mass measurements of the protonated molecules were m/z 256.1703 and 256.1696 compared to the calculated mass of m/z 256.1701, resulting in errors of 0.8 and 2.3 ppm. This mass accuracy was sufficient to verify the elemental composition of diphenhydramine in each sample. Furthermore, accurate mass measurements of the primary fragment ion were obtained. This work is the first application of time-of-flight mass spectrometry for the identification of diphenhydramine and shows the accumulation of an over-the-counter medication in aquatic sediments at five different locations.

Solar observations with the prototype of the Brazilian Decimetric Array

NASA Astrophysics Data System (ADS)

Sawant, H. S.; Ramesh, R.; Faria, C.; Cecatto, J. R.; Fernandes, F. C. R.; Madsen, F. H. R.; Subramanian, K. R.; Sundararajan, M. S.

The prototype of the Brazilian Decimetric Array BDA consists of 5 element alt-az mounted parabolic mesh type dishes of 4-meter diameter having base lines up to 220 meters in the E--W direction The array was put into regular operation at Cachoeira Paulista Brazil longitude 45 r 00 20 W and latitude 22 r 41 19 S This array operates in the frequency range of 1 2 -- 1 7 GHz Solar observations are carried at sim 1 4 GHz in transit and tracking modes Spatial fine structures superimposed on the one dimensional brightness map of the sun associated with active regions and or with solar activity and their time evolution will be presented In the second phase of the project the frequency range will be increased to 1 2 - 1 7 2 8 and 5 6 GHz Central part of the array will consist of 26 antennas with 4-meter diameter laid out randomically in the square of 256 by 256 meter with minimum and maximum base lines of 8 and 256 meters respectively Details of this array with imaging capabilities in snap shot mode for solar observations and procedure of the phase and amplitude calibrations will be presented The development of instrument will be completed by the beginning of 2008

A synergetic biomineralization strategy for immobilizing strontium during calcification of the coccolithophore Emiliania huxleyi.

PubMed

Sun, Shiyong; Liu, Mingxue; Nie, Xiaoqin; Dong, Faqin; Hu, Wenyuan; Tan, Daoyong; Huo, Tingting

2018-01-24

The coccolithophore species Emiliania huxleyi has one of the most global distributions in the modern oceans. They are characteristically covered with calcite scales called coccoliths. In this study, stable strontium immobilization during the calcification process was investigated to indirectly assess a proposed bioremediation approach for removing Sr 2+ contamination from marine environments. Results indicate that E. huxleyi has high Sr 2+ tolerance and removal efficiency in response to Sr 2+ stress ranging from 5.6 to 105.6 ppm. Sr 2+ immobilization during E. huxleyi calcification indicates a concentration-dependent synergistic mechanism. At lower concentrations of Sr 2+ (25.6 ppm), Sr 2+ is incorporated into coccoliths through competitive supply between Sr 2+ and Ca 2+ . In addition, calcite productivity decreases with increased Sr 2+ removal efficiency due to crystallographic transformation of coccoliths from hydrated calcite into aragonite at 55.6 ppm Sr 2+ . Further formation of strontianite at 105.6 ppm Sr 2+ is due to precipitation of Sr 2+ on the edge of the rims and radial arrays of the coccoliths. Our study implies that coccolithophores are capable of significant removal of Sr 2+ from the marine environment.

Coagulase-Negative Staphylococci in Human Milk From Mothers of Preterm Compared With Term Neonates.

PubMed

Soeorg, Hiie; Metsvaht, Tuuli; Eelmäe, Imbi; Metsvaht, Hanna Kadri; Treumuth, Sirli; Merila, Mirjam; Ilmoja, Mari-Liis; Lutsar, Irja

2017-05-01

Human milk is the preferred nutrition for neonates and a source of bacteria. Research aim: The authors aimed to characterize the molecular epidemiology and genetic content of staphylococci in the human milk of mothers of preterm and term neonates. Staphylococci were isolated once per week in the 1st month postpartum from the human milk of mothers of 20 healthy term and 49 preterm neonates hospitalized in the neonatal intensive care unit. Multilocus variable-number tandem-repeats analysis and multilocus sequence typing were used. The presence of the mecA gene, icaA gene of the ica-operon, IS 256, and ACME genetic elements was determined by PCR. The human milk of mothers of preterm compared with term neonates had higher counts of staphylococci but lower species diversity. The human milk of mothers of preterm compared with term neonates more often contained Staphylococcus epidermidis mecA (32.7% vs. 2.6%), icaA (18.8% vs. 6%), IS 256 (7.9% vs. 0.9%), and ACME (15.4% vs. 5.1%), as well as Staphylococcus haemolyticus mecA (90.5% vs. 10%) and IS 256 (61.9% vs. 10%). The overall distribution of multilocus variable-number tandem-repeats analysis (MLVA) types and sequence types was similar between the human milk of mothers of preterm and term neonates, but a few mecA-IS 256-positive MLVA types colonized only mothers of preterm neonates. Maternal hospitalization within 1 month postpartum and the use of an arterial catheter or antibacterial treatment in the neonate increased the odds of harboring mecA-positive staphylococci in human milk. Limiting exposure of mothers of preterm neonates to the hospital could prevent human milk colonization with more pathogenic staphylococci.

[Expressions of angiogenesis-related factors: CD105, EphA2 and EphrinA1 in laryngeal squamous cell carcinoma and clinical implication].

PubMed

Su, J; Ji, X B; Xie, J H; Li, W

2016-12-07

Objective: To investigate the expressions of endoglin (CD105), erythropoietin-producing hepatocyte receptor A2 (EphA2) and its ligand ephrinA1 proteins in laryngeal squamous cell carcinoma (LSCC) and the relationship between their expressions and the clinicopathological factors of LSCC. Methods: The expressions of CD105, EphA2 and EphrinA1 proteins were detected with immunohistochemical staining in LSCC in 76 cases and adjacent normal laryngeal tissues (ANLT) (S-P) in 25 cases.SPSS 17.0 software was used to analyze the data. Results: The mean microvessel density (MVD) value marked by CD105 staining in LSCC was 10.33±2.29, which was significantly higher than that in ANLT(1.20±1.04, t =18.732, P <0.05). The CD105-MVD was correlated with T stage, histological grading, clinical stage, lymph node metastasis, recurrence and prognosis in LSCC (F value was 5.34, 4.79, 5.36, t value was -2.70, 2.56, all P <0.05). The positive expression rates of EphA2 and EphrinA1 in LSCC were 78.95% (60/76), and 81.85% (62/76), which were respectively significantly higher than 40% (10/25) for EphA2 expression and 44% (11/25) for EphrinA1, expression in ANLT (χ 2 value was 13.41, 13.26, both P <0.05). EphA2 expression was correlated with histological grading, T stage, clinical stage, lymph node metastasis, recurrence and prognosis in LSCC (χ 2 value was 6.25, 14.60, 15.11, 8.52, 5.54, all P <0.05). EphrinA1 expression was correlated with T stage, clinical stage, lymph node metastasis, recurrence and prognosis in LSCC (χ 2 value was 6.44, 12.28, 16.78, 6.44, all P <0.05). The expressions of CD105, EphA2 and EphrinA1 were positively correlated with each other r value was 0.72, 0.74, 0.64, all P <0.05. Survival analysis indicated that the expressions of CD105 and EphA2, histological grading, lymph node metastasis, clinical stage and recurrence were independent factors for tumor prognosis in LSCC ( P <0.05). Conclusions: The expressions of CD105, EphA2 and EphrinA1 protein were positively correlated with each other in LSCC. They may play important roles in the tumorigenesis, malignant progression and poor prognosis of LSCC.

Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine.

PubMed

Félix, Luís M; Antunes, Luís M; Coimbra, Ana M; Valentim, Ana M

2017-02-01

Ketamine has been associated with pediatric risks that include neurocognitive impairment and long-term behavioral disorders. However, the neurobehavioral effects of ketamine exposure in early development remain uncertain. This study aimed to test stage- and dose-dependent effects of ketamine exposure on certain brain functions by evaluating alterations in locomotion, anxiety-like and avoidance behaviors, as well as socialization. Embryos were exposed to different concentrations of ketamine (0, 0.2, 0.4, and 0.8 mg mL -1 ) for 20 min during the 256-cell (2.5 h post fertilization-hpf), 50% epiboly (5.5 hpf), and 1-4 somites (10.5 hpf) stages. General exploratory activities, natural escape-like responses, and social interactions were analyzed under continuous light or under a moving light stimulus. A dose-dependent decrease in the overall mean speed was perceived in the embryos exposed during the 256-cell stage. These results were related to previously observed head and eye malformations, following ketamine exposure at this stage and may indicate possible neurobehavioral disorders when ketamine exposure is performed at this stage. Results also showed that ketamine exposure during the 50% epiboly and 1-4 somites stages induced a significant increment of the anxiety-like behavior and a decrease in avoidance behavior in all exposed groups. Overall, the results validate the neurodevelopmental risks of early-life exposure to ketamine.

14C autoradiography with an energy-sensitive silicon pixel detector.

PubMed

Esposito, M; Mettivier, G; Russo, P

2011-04-07

The first performance tests are presented of a carbon-14 ((14)C) beta-particle digital autoradiography system with an energy-sensitive hybrid silicon pixel detector based on the Timepix readout circuit. Timepix was developed by the Medipix2 Collaboration and it is similar to the photon-counting Medipix2 circuit, except for an added time-based synchronization logic which allows derivation of energy information from the time-over-threshold signal. This feature permits direct energy measurements in each pixel of the detector array. Timepix is bump-bonded to a 300 µm thick silicon detector with 256 × 256 pixels of 55 µm pitch. Since an energetic beta-particle could release its kinetic energy in more than one detector pixel as it slows down in the semiconductor detector, an off-line image analysis procedure was adopted in which the single-particle cluster of hit pixels is recognized; its total energy is calculated and the position of interaction on the detector surface is attributed to the centre of the charge cluster. Measurements reported are detector sensitivity, (4.11 ± 0.03) × 10(-3) cps mm(-2) kBq(-1) g, background level, (3.59 ± 0.01) × 10(-5) cps mm(-2), and minimum detectable activity, 0.0077 Bq. The spatial resolution is 76.9 µm full-width at half-maximum. These figures are compared with several digital imaging detectors for (14)C beta-particle digital autoradiography.

Design and Characterization of Dual-Curvature 1.5-Dimensional High-Intensity Focused Ultrasound Phased-Array Transducer

PubMed Central

Chen, Gin-Shin; Lin, Che-Yu; Jeong, Jong Seob; Cannata, Jonathan M.; Lin, Win-Li; Chang, Hsu; Shung, K. Kirk

2013-01-01

A dual-curvature focused ultrasound phased-array transducer with a symmetric control has been developed for noninvasive ablative treatment of tumors. The 1.5-D array was constructed in-house and the electro-acoustic conversion efficiency was measured to be approximately 65%. In vitro experiments demonstrated that the array uses 256 independent elements to achieve 2-D wide-range high-intensity electronic focusing. PMID:22293745

40 CFR Table A-6 to Subpart A of... - Data Elements That Are Inputs to Emission Equations and for Which the Reporting Deadline Is...

Code of Federal Regulations, 2011 CFR

2011-07-01

... to calculate recycling correction factor). Y 98.256(i)(5) Only annual mass of green coke fed, carbon...) All. GG 98.336(b)(7) All. GG 98.336(b)(10) All. HH 98.346(a) Only year in which landfill first accepted waste, last year the landfill accepted waste, capacity of the landfill, and waste disposal...

An Overview of Antenna R&D Efforts in Support of NASA's Space Exploration Vision

NASA Technical Reports Server (NTRS)

Manning, Robert M.

2007-01-01

This presentation reviews the research and development work being conducted at Glenn Research Center in the area of antennas for space exploration. In particular, after reviewing the related goals of the agency, antenna technology development at GRC is discussed. The antennas to be presented are large aperture inflatable antennas, phased array antennas, a 256 element Ka-band antenna, a ferroelectric reflectarray antenna, multibeam antennas, and several small antennas.

STS-105 Crew Training in VR Lab

NASA Image and Video Library

2001-03-15

JSC2001-00751 (15 March 2001) --- Astronaut Scott J. Horowitz, STS-105 mission commander, uses the virtual reality lab at the Johnson Space Center (JSC) to train for his duties aboard the Space Shuttle Discovery. This type of computer interface paired with virtual reality training hardware and software helps to prepare the entire team for dealing with International Space Station (ISS) elements.

STS-105 Crew Training in VR Lab

NASA Image and Video Library

2001-03-15

JSC2001-00758 (15 March 2001) --- Astronaut Frederick W. Sturckow, STS-105 pilot, uses the virtual reality lab at the Johnson Space Center (JSC) to train for his duties aboard the Space Shuttle Discovery. This type of computer interface paired with virtual reality training hardware and software helps to prepare the entire team for dealing with International Space Station (ISS) elements.

Synthesis and electrochemical characterization of Li 1.05RE xCr yMn 2- x- yO 4 spinel as cathode material for rechargeable Li-battery

NASA Astrophysics Data System (ADS)

Xie, Yanting; Yang, Rudong; Yan, Lan; Qi, Lu; Dai, Kehua; He, Ping

The spinel phases of Li 1.05RE xCr yMn 2- x- yO 4 (RE = Sc, Ce, Pr, Tb; 0 ≤ x ≤ 0.05; 0 ≤ y ≤ 0.1) were prepared by a soft chemical method. The structural and electrochemical properties of Li 1.05RE xCr yMn 2- x- yO 4 were investigated by X-ray diffraction (XRD), Transmission electron microscopy (TEM) and charge-discharge experiments. Rare earth element-Sc and transition metal-Cr as co-substituents stabilize the spinel framework and improve charge-discharge performance. For Li 1.05Sc 0.01Cr 0.03Mn 1.96O 4, the capacity of the cell maintained 95% of the initial capacity at the 80th cycle. The rare earth elements of the variable valent metals such as Ce 3+/4+, Pr 3+/4+, Tb 3+/4+ with transition metal Cr 3+ as co-substituent do not stable framework of spinel or improve the cycling performance. Cyclic voltammetry (CV) were measured to provide clues for the improved cycling performance of cathode electrodes.

Improved Aeroprediction Code. Part 1. Summary of New Methods and Comparison with Experiment

DTIC Science & Technology

1993-05-01

and the results stored in tabular form as functions of Mach number, altitude, and angle of attack. This information can then be accessed by an...WIGBD9AI3OFGRAINUE 10 VALIDATIO ..... PRO .. SS7 . ..CON .......U... 5 ....... ... ........ .. . .. .. ...4-6 0 .......... NSWCDD/TR-93/9 I 256 AP 01 APIS3 1...Unit Block 13. Abstract. Include a brief (Maximum 200 Element Accession No. words) factual summary of the most significant information contained in

Information Warfare and Cyber Defense

DTIC Science & Technology

2002-04-22

Information Technology Trends Power Is Up 1980 1982 1986 1989 1992 1996 1998 2000 286 386 486 Pentium P6 Pentium 4 286k 1MB 4MB 16MB 64MB 256 MB...384 MBDRAM CPU (Source: EIA, CNET, Gartner, Dell -- 2000) 2002 512 MB Pentium 4/ Celeron 5 Information Technology Trends Price Is Down Cost per MIPS...Operations Architecture Technology Info Assurance PDD-56 PDD-63 PDD-68 Information Operations Focus Areas Elements • PSYOP • Deception • EW •

The Remote Analysis Station (RAS) as an instructional system

NASA Technical Reports Server (NTRS)

Rogers, R. H.; Wilson, C. L.; Dye, R. H.; Jaworski, E.

1981-01-01

"Hands-on" training in LANDSAT data analysis techniques can be obtained using a desk-top, interactive remote analysis station (RAS) which consists of a color CRT imagery display, with alphanumeric overwrite and keyboard, as well as a cursor controller and modem. This portable station can communicate via modem and dial-up telephone with a host computer at 1200 baud or it can be hardwired to a host computer at 9600 baud. A Z80 microcomputer controls the display refresh memory and remote station processing. LANDSAT data is displayed as three-band false-color imagery, one-band color-sliced imagery, or color-coded processed imagery. Although the display memory routinely operates at 256 x 256 picture elements, a display resolution of 128 x 128 can be selected to fill the display faster. In the false color mode the computer packs the data into one 8-bit character. When the host is not sending pictorial information the characters sent are in ordinary ASCII code. System capabilities are described.

Astronomical image data compression by morphological skeleton transformation

NASA Astrophysics Data System (ADS)

Huang, L.; Bijaoui, A.

A compression method adapted for exact restoring of the detected objects and based on the morphological skeleton transformation is presented. The morphological skeleton provides a complete and compact description of an object and gives an efficient compression rate. The flexibility of choosing a structuring element adapted to different images and the simplicity of the implementation are considered to be advantages of the method. The experiment was carried out on three typical astronomical images. The first two images were obtained by digitizing a Palomar Schmidt photographic plate in a coma field with the PDS microdensitometer at Nice Observatory. The third image was obtained by CCD camera at the Pic du Midi Observatory. Each pixel was coded by 16 bits and stored at a computer system (VAX785) with STII format. Each image is characterized by 256 x 256 pixels. It is found that first image represents a stellar field, the second represents a set of galaxies in the Coma, and the third image contains an elliptical galaxy.

Extraction, characterization and antioxidant activities of Se-enriched tea polysaccharides.

PubMed

Wang, Yuanfeng; Li, Yongfu; Liu, Yangyang; Chen, Xueqing; Wei, Xinlin

2015-01-01

Se-polysaccharides from Se-enriched tea leaves were purified by DEAE-sepharose fast flow gel column (2.5×60cm) and three polysaccharide fractions (Se-TPS1, Se-TPS2, and Se-TPS3) were isolated and purified with yields of 6.5, 37.14, and 8.57%, respectively. The average sizes of Se-TPS1 and Se-TPS2 were determined by HPGPC system, with molecular weights of 1.1×10(5) and 2.4×10(5)Da, respectively. Se-TPS3 was a polysaccharide polymer with two peaks with molecular weights of 9.2×10(5) and 2.5×10(5)Da. Monosaccharide components analysis by ion chromatography revealed Se-polysaccharides were acidic polysaccharoses and different from each other in monosaccharide kinds and molar ratio. Elements of Se, C, H, N, S, and 14 kinds of mineral elements were analyzed by AFS, EA, and ICP-AES, respectively. Spectral analysis (IR and UV) indicated Se-polysaccharides were typical glycoproteins. Morphological analyses of the samples were determined by SEM and AFM. In addition, the DPPH and superoxide radicals scavenging activities were also discussed to assess antioxidant activities of the samples, and Se-polysaccharides showed higher antioxidant activities compared to the ordinary polysaccharides. Copyright © 2015 Elsevier B.V. All rights reserved.

Dual-Use of Compact HF Radars for the Detection of Mid-and Large-size Vessels

DTIC Science & Technology

2010-01-01

make detecting a ship nearby very difficult. The zero-Doppler is from signals returned from any stationary object wile the sea-echo Bragg peaks are due...the six detection processes IIR-128 (blue), IIR-256 (red), IIR-256 (magenta), Median-64 (dark brown ), Median-128 ( brown ), Median-256 (dark green). As...IIR-256 (red), IIR-256 (magenta), Median-64 (dark brown ), Median-128 ( brown ), Median-256 (dark green). Acknowledgements This work was funded by the

AQP2 Plasma Membrane Diffusion Is Altered by the Degree of AQP2-S256 Phosphorylation

PubMed Central

Arnspang, Eva C.; Login, Frédéric H.; Koffman, Jennifer S.; Sengupta, Prabuddha; Nejsum, Lene N.

2016-01-01

Fine tuning of urine concentration occurs in the renal collecting duct in response to circulating levels of arginine vasopressin (AVP). AVP stimulates intracellular cAMP production, which mediates exocytosis of sub-apical vesicles containing the water channel aquaporin-2 (AQP2). Protein Kinase A (PKA) phosphorylates AQP2 on serine-256 (S256), which triggers plasma membrane accumulation of AQP2. This mediates insertion of AQP2 into the apical plasma membrane, increasing water permeability of the collecting duct. AQP2 is a homo-tetramer. When S256 on all four monomers is changed to the phosphomimic aspartic acid (S256D), AQP2-S256D localizes to the plasma membrane and internalization is decreased. In contrast, when S256 is mutated to alanine (S256A) to mimic non-phosphorylated AQP2, AQP2-S256A localizes to intracellular vesicles as well as the plasma membrane, with increased internalization from the plasma membrane. S256 phosphorylation is not necessary for exocytosis and dephosphorylation is not necessary for endocytosis, however, the degree of S256 phosphorylation is hypothesized to regulate the kinetics of AQP2 endocytosis and thus, retention time in the plasma membrane. Using k-space Image Correlation Spectroscopy (kICS), we determined how the number of phosphorylated to non-phosphorylated S256 monomers in the AQP2 tetramer affects diffusion speed of AQP2 in the plasma membrane. When all four monomers mimicked constitutive phosphorylation (AQP2-S256D), diffusion was faster than when all four were non-phosphorylated (AQP2-S256A). AQP2-WT diffused at a speed similar to that of AQP2-S256D. When an average of two or three monomers in the tetramer were constitutively phosphorylated, the average diffusion coefficients were not significantly different to that of AQP2-S256D. However, when only one monomer was phosphorylated, diffusion was slower and similar to AQP2-S256A. Thus, AQP2 with two to four phosphorylated monomers has faster plasma membrane kinetics, than the tetramer which contains just one or no phosphorylated monomers. This difference in diffusion rate may reflect behavior of AQP2 tetramers destined for either plasma membrane retention or endocytosis. PMID:27801846

AQP2 Plasma Membrane Diffusion Is Altered by the Degree of AQP2-S256 Phosphorylation.

PubMed

Arnspang, Eva C; Login, Frédéric H; Koffman, Jennifer S; Sengupta, Prabuddha; Nejsum, Lene N

2016-10-28

Fine tuning of urine concentration occurs in the renal collecting duct in response to circulating levels of arginine vasopressin (AVP). AVP stimulates intracellular cAMP production, which mediates exocytosis of sub-apical vesicles containing the water channel aquaporin-2 (AQP2). Protein Kinase A (PKA) phosphorylates AQP2 on serine-256 (S256), which triggers plasma membrane accumulation of AQP2. This mediates insertion of AQP2 into the apical plasma membrane, increasing water permeability of the collecting duct. AQP2 is a homo-tetramer. When S256 on all four monomers is changed to the phosphomimic aspartic acid (S256D), AQP2-S256D localizes to the plasma membrane and internalization is decreased. In contrast, when S256 is mutated to alanine (S256A) to mimic non-phosphorylated AQP2, AQP2-S256A localizes to intracellular vesicles as well as the plasma membrane, with increased internalization from the plasma membrane. S256 phosphorylation is not necessary for exocytosis and dephosphorylation is not necessary for endocytosis, however, the degree of S256 phosphorylation is hypothesized to regulate the kinetics of AQP2 endocytosis and thus, retention time in the plasma membrane. Using k-space Image Correlation Spectroscopy (kICS), we determined how the number of phosphorylated to non-phosphorylated S256 monomers in the AQP2 tetramer affects diffusion speed of AQP2 in the plasma membrane. When all four monomers mimicked constitutive phosphorylation (AQP2-S256D), diffusion was faster than when all four were non-phosphorylated (AQP2-S256A). AQP2-WT diffused at a speed similar to that of AQP2-S256D. When an average of two or three monomers in the tetramer were constitutively phosphorylated, the average diffusion coefficients were not significantly different to that of AQP2-S256D. However, when only one monomer was phosphorylated, diffusion was slower and similar to AQP2-S256A. Thus, AQP2 with two to four phosphorylated monomers has faster plasma membrane kinetics, than the tetramer which contains just one or no phosphorylated monomers. This difference in diffusion rate may reflect behavior of AQP2 tetramers destined for either plasma membrane retention or endocytosis.

Destroyer Engineered Operating Cycle (DDEOC), System Maintenance Analysis DDG-37 Class, Salt Water Circulating System SMA 37-106-256, Review of Experience

DTIC Science & Technology

1978-07-01

horizontally mounted, single-end suction, single- stage centrifugal pumps. The rotating elements are mounted on the shaft of the driving motor, and the pump...annual open-and-inspect requirement for MIP E-17/296-21, MRC 21 A14V A. Industrial Facility Improvements -- None IMA Improvements -- None Intergrated ...Circulating Pump, Warren Pumps, Inc., NAVSHIPS 347-3146, January 1959. 4. Technical Manual - Horizontal Close-Co!;pled Pumps Sea (Salt) Water

Implementation of a noise reduction circuit for spaceflight IR spectrometers

NASA Technical Reports Server (NTRS)

Ramirez, L.; Hickok, R.; Pain, B.; Staller, C.

1992-01-01

The paper discusses the implementation and analysis of a correlated triple sampling circuit using analog subtractor/integrators. The software and test setup for noise measurements are also described. The correlation circuitry is part of the signal chain for a 256-element InSb line array used in the Visible and Infrared Mapping Spectrometer. Using a focal-plane array (FPA) simulator, system noise measurements of 0.7 DN are obtained. A test setup for FPA/SPE (signal processing electronics) characterization along with noise measurements is demonstrated.

Multi-Core Programming Design Patterns: Stream Processing Algorithms for Dynamic Scene Perceptions

DTIC Science & Technology

2014-05-01

processor developed by IBM and other companies , incorpo- rates the verb—POWER5— processor as the Power Processor Element (PPE), one of the early general...deliver an power efficient single-precision peak performance of more than 256 GFlops. Substantially more raw power became available later, when nVIDIA ...algorithms, including IBM’s Cell/B.E., GPUs from NVidia and AMD and many-core CPUs from Intel.27 The vast growth of digital video content has been a

Water analysis via portable X-ray fluorescence spectrometry

NASA Astrophysics Data System (ADS)

Pearson, Delaina; Chakraborty, Somsubhra; Duda, Bogdan; Li, Bin; Weindorf, David C.; Deb, Shovik; Brevik, Eric; Ray, D. P.

2017-01-01

Rapid, in-situ elemental water analysis would be an invaluable tool in studying polluted and/or salt-impacted waters. Analysis of water salinity has commonly used electrical conductance (EC); however, the identity of the elements responsible for the salinity are not revealed using EC. Several studies have established the viability of using portable X-ray fluorescence (PXRF) spectrometry for elemental data analysis of soil, sediment, and other matrices. However, the accuracy of PXRF is known to be affected while scanning moisture-laden soil samples. This study used PXRF elemental data in water samples to predict water EC. A total of 256 water samples, from 10 different countries were collected and analyzed via PXRF, inductively coupled plasma atomic emission spectroscopy (ICP-AES), and a digital salinity bridge. The PXRF detected some elements more effectively than others, but overall results indicated that PXRF can successfully predict water EC via quantifying Cl in water samples (validation R2 and RMSE of 0.77 and 0.95 log μS cm-1, respectively). The findings of this study elucidated the potential of PXRF for future analysis of pollutant and/or metal contaminated waters.

802GHz integrated horn antennas imaging array

NASA Technical Reports Server (NTRS)

Ali-Ahmad, Walid Y.; Rebeiz, Gabriel M.; Dave, Hemant; Chin, Gordon

1991-01-01

Pattern measurements at 802GHz of a single element in 256-element integrated horn imaging array are presented. The integrated-horn antenna consists of a dipole-antenna suspended on a 1-micron dielectric membrane inside a pyramidal cavity etched in silicon. The theoretical far-field patterns, calculated using reciprocity and Floquet-modes representation of the free-space field, agree well with the measured far-field patterns at 802GHz. The associated directivity for a 1.40 lambda horn aperture, calculated from the measured E and H-plane patterns is 12.3dB + or - 0.2dB. This work demonstrates that high-efficiency integrated-horn antennas are easily scalable to terahertz frequencies and could be used for radio-astronomical and plasma-diagnostic applications.

Requirement of Hsp105 in CoCl{sub 2}-induced HIF-1α accumulation and transcriptional activation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mikami, Hiroki; Saito, Youhei, E-mail: ysaito@mb.kyoto-phu.ac.jp; Okamoto, Namiko

The mammalian stress protein Hsp105α protects cells from stress conditions. Several studies have indicated that Hsp105α is overexpressed in many types of solid tumors, which contain hypoxic microenvironments. However, the role of Hsp105α in hypoxic tumors remains largely unknown. We herein demonstrated the involvement of Hsp105α in HIF-1 functions induced by the hypoxia-mimetic agent CoCl{sub 2}. While Hsp105α is mainly localized in the cytoplasm under normal conditions, a treatment with CoCl{sub 2} induces the nuclear localization of Hsp105α, which correlated with HIF-1α expression levels. The overexpression of degradation-resistant HIF-1α enhances the nuclear localization of Hsp105α without the CoCl{sub 2} treatment.more » The CoCl{sub 2}-dependent transcriptional activation of HIF-1, which is measured using a reporter gene containing a HIF-responsive element, is reduced by the knockdown of Hsp105α. Furthermore, the CoCl{sub 2}-induced accumulation of HIF-1α is enhanced by heat shock, which results in the nuclear localization of Hsp105, and is suppressed by the knockdown of Hsp105. Hsp105 associates with HIF-1α in CoCl{sub 2}-treated cells. These results suggest that Hsp105α plays an important role in the functions of HIF-1 under hypoxic conditions, in which Hsp105α enhances the accumulation and transcriptional activity of HIF-1 through the HIF-1α-mediated nuclear localization of Hsp105α. - Highlights: • Hsp105α is required for the CoCl{sub 2}-induced transcriptional activation and accumulation of HIF-1. • Hsp105α localizes to the nucleus and interacts with HIF-1α in CoCl{sub 2}-treated cells. • Hsp105 enhances the CoCl{sub 2}-induced accumulation of HIF-1α under heat shock conditions.« less

A novel digital image sensor with row wise gain compensation for Hyper Spectral Imager (HySI) application

NASA Astrophysics Data System (ADS)

Lin, Shengmin; Lin, Chi-Pin; Wang, Weng-Lyang; Hsiao, Feng-Ke; Sikora, Robert

2009-08-01

A 256x512 element digital image sensor has been developed which has a large pixel size, slow scan and low power consumption for Hyper Spectral Imager (HySI) applications. The device is a mixed mode, silicon on chip (SOC) IC. It combines analog circuitry, digital circuitry and optical sensor circuitry into a single chip. This chip integrates a 256x512 active pixel sensor array, a programming gain amplifier (PGA) for row wise gain setting, I2C interface, SRAM, 12 bit analog to digital convertor (ADC), voltage regulator, low voltage differential signal (LVDS) and timing generator. The device can be used for 256 pixels of spatial resolution and 512 bands of spectral resolution ranged from 400 nm to 950 nm in wavelength. In row wise gain readout mode, one can set a different gain on each row of the photo detector by storing the gain setting data on the SRAM thru the I2C interface. This unique row wise gain setting can be used to compensate the silicon spectral response non-uniformity problem. Due to this unique function, the device is suitable for hyper-spectral imager applications. The HySI camera located on-board the Chandrayaan-1 satellite, was successfully launched to the moon on Oct. 22, 2008. The device is currently mapping the moon and sending back excellent images of the moon surface. The device design and the moon image data will be presented in the paper.

The 150 ns detector project: Prototype preamplifier results

NASA Astrophysics Data System (ADS)

Warburton, W. K.; Russell, S. R.; Kleinfelder, Stuart A.

1994-08-01

The long-term goal of the 150 ns detector project is to develop a pixel area detector capable of 6 MHz frame rates (150 ns/frame). Our milestones toward this goal are: a single pixel, 1×256 1D and 8×8 2D detectors, 256×256 2D detectors and, finally, 1024 × 1024 2D detectors. The design strategy is to supply a complete electronics chain (resetting preamp, selectable gain amplifier, analog-to-digital converter (ADC), and memory) for each pixel. In the final detectors these will all be custom integrated circuits. The front-end preamplifiers are integrated first, since their design and performance are the most unusual and also critical to the project's success. Similarly, our early work is concentrated on devising and perfecting detector structures. In this paper we demonstrate the performance of prototypes of our integrated preamplifiers. While the final design will have 64 preamps to a chip, including a switchable gain stage, the prototypes were integrated 8 channels to a "Tiny Chip" and tested in 4 configurations (feedback capacitor Cf equal 2.5 or 4.0 pF, output directly or through a source follower). These devices have been tested thoroughly for reset settling times, gain, linearity, and electronic noise. They generally work as designed, being fast enough to easily integrate detector charge, settle, and reset in 150 ns. Gain and linearity appear to be acceptable. Current values of electronic noise, in double-sampling mode, are about twice the design goal of {2}/{3} of a single photon at 6 keV. We expect this figure to improve with the addition of the onboard amplifier stage and improved packaging. Our next test chip will include these improvements and allow testing with our first detector samples, which will be 1×256 (50 μm wide pixels) and 8×8 (1 mm 2 pixels) element detector on 1 mm thick silicon.

Evaluation of ADINA. Part I. Theory and Programing Descriptions.

DTIC Science & Technology

1980-06-08

Problem," Numerical and Computer Methods in Structural Mechanics, S. J. Feaves, N. Pe-rone, J. Robinson and W.C. Schnobrich, eds., Academic Press, New...connectivity array N102 ’NDM*NlJME-ITW0 YL Element nodal coordinates N103 ---- NUME IELT Element number of nodes N104 NUME IPST Stress printing flag N105 NUME

Testing a Model of Diabetes Self-Care Management: A Causal Model Analysis with LISREL.

ERIC Educational Resources Information Center

Nowacek, George A.; And Others

1990-01-01

A diabetes-management model is presented, which includes an attitudinal element and depicts relationships among causal elements. LISREL-VI was used to analyze data from 115 Type-I and 105 Type-II patients. The data did not closely fit the model. Results support the importance of the personal meaning of diabetes. (TJH)

25 CFR 256.26 - Can I receive Housing Improvement Program services if I am living in a mobile home?

Code of Federal Regulations, 2010 CFR

2010-04-01

... am living in a mobile home? 256.26 Section 256.26 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... I am living in a mobile home? Yes. If you meet the eligibility criteria in § 256.6 and there is... § 256.7. If you require Category B services and your mobile home has exterior walls of less than three...

40 CFR 256.40 - Requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements. 256.40 Section 256.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.40...

40 CFR 256.40 - Requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements. 256.40 Section 256.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.40...

40 CFR 256.40 - Requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements. 256.40 Section 256.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.40...

40 CFR 256.40 - Requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements. 256.40 Section 256.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.40...

40 CFR 256.40 - Requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements. 256.40 Section 256.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.40...

40 CFR 256.11 - Recommendations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommendations. 256.11 Section 256.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT...; Distribution of Funding § 256.11 Recommendations. (a) Responsibilities should be identified for each of the...

40 CFR 256.11 - Recommendations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommendations. 256.11 Section 256.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT...; Distribution of Funding § 256.11 Recommendations. (a) Responsibilities should be identified for each of the...

17 CFR 38.256 - Trade reconstruction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Trade reconstruction. 38.256 Section 38.256 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DESIGNATED CONTRACT MARKETS Prevention of Market Disruption § 38.256 Trade reconstruction. The designated contract market must...

17 CFR 38.256 - Trade reconstruction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Trade reconstruction. 38.256 Section 38.256 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION DESIGNATED CONTRACT MARKETS Prevention of Market Disruption § 38.256 Trade reconstruction. The designated contract market must...

Addition of transcription activator-like effector binding sites to a pathogen strain-specific rice bacterial blight resistance gene makes it effective against additional strains and against bacterial leaf streak.

PubMed

Hummel, Aaron W; Doyle, Erin L; Bogdanove, Adam J

2012-09-01

Xanthomonas transcription activator-like (TAL) effectors promote disease in plants by binding to and activating host susceptibility genes. Plants counter with TAL effector-activated executor resistance genes, which cause host cell death and block disease progression. We asked whether the functional specificity of an executor gene could be broadened by adding different TAL effector binding elements (EBEs) to it. We added six EBEs to the rice Xa27 gene, which confers resistance to strains of the bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) that deliver the TAL effector AvrXa27. The EBEs correspond to three other effectors from Xoo strain PXO99(A) and three from strain BLS256 of the bacterial leaf streak pathogen Xanthomonas oryzae pv. oryzicola (Xoc). Stable integration into rice produced healthy lines exhibiting gene activation by each TAL effector, and resistance to PXO99(A) , a PXO99(A) derivative lacking AvrXa27, and BLS256, as well as two other Xoo and 10 Xoc strains virulent toward wildtype Xa27 plants. Transcripts initiated primarily at a common site. Sequences in the EBEs were found to occur nonrandomly in rice promoters, suggesting an overlap with endogenous regulatory sequences. Thus, executor gene specificity can be broadened by adding EBEs, but caution is warranted because of the possible coincident introduction of endogenous regulatory elements. © 2012 The Authors. New Phytologist © 2012 New Phytologist Trust.

One-Step Derivatization-Extraction Method for Rapid Analysis of Eleven Amphetamines and Cathinones in Oral Fluid by GC-MS.

PubMed

Mohamed, Khaled

2017-09-01

A simple analytical method was developed for in-matrix derivatization of 11 amphetamine-like molecules. Ethyl chloroformate as the derivatization reagent and ethyl acetate as the extraction solvent were added directly to oral fluid samples at alkaline pH. Samples were analyzed by gas chromatography-mass spectrometry. Ions monitored for quantification were m/z 44, 91 and 116 for amphetamine (AMP); m/z 58, 91 and 130 for methamphetamine (MA); m/z 44, 105 and 116 for 4-methylamphetamine; m/z 44, 116 and 251 for 3,4-methylenedioxyamphetamine; m/z 58, 130 and 265 for 3,4-methylenedioxymethamphetamine (MDMA); m/z 72, 116 and 144 for 3,4-methylenedioxyethylamphetamine; m/z 44, 105 and 116 for cathinone; m/z 58, 105 and 130 for methcathinone; m/z 58, 119 and 130 for mephedrone; m/z 58, 107 and 130 for ephedrine (EPH); m/z 207, 250 and 322 for fenethylline; m/z 48, 92 and 120 for AMP-D5; m/z 62, 92 and 134 for MA-D5; m/z 48, 120 and 256 for MDA-D5; and m/z 62, 134 and 270 for MDMA-D5. The underlined ions were used as quantifier ions. Calibration curves were linear in the concentration range of 2.5-1,000 ng/mL for all analytes except for EPH, which was linear within 5-1,000 ng/mL. Precision and accuracy were less than 12.9% (relative standard deviation) and ±12.8% (bias), respectively, for all analytes. The method was tested in the analysis of oral fluid specimens collected from users. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

7 CFR 2018.256-2018.300 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false [Reserved] 2018.256-2018.300 Section 2018.256-2018.300 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... (CONTINUED) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information §§ 2018.256-2018.300 [Reserved] ...

7 CFR 2018.256-2018.300 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false [Reserved] 2018.256-2018.300 Section 2018.256-2018.300 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... (CONTINUED) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information §§ 2018.256-2018.300 [Reserved] ...

7 CFR 2018.256-2018.300 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false [Reserved] 2018.256-2018.300 Section 2018.256-2018.300 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... (CONTINUED) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information §§ 2018.256-2018.300 [Reserved] ...

7 CFR 2018.256-2018.300 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false [Reserved] 2018.256-2018.300 Section 2018.256-2018.300 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... (CONTINUED) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information §§ 2018.256-2018.300 [Reserved] ...

7 CFR 2018.256-2018.300 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false [Reserved] 2018.256-2018.300 Section 2018.256-2018.300 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... (CONTINUED) ADMINISTRATIVE REGULATIONS GENERAL Availability of Information §§ 2018.256-2018.300 [Reserved] ...

Boiler-turbine life extension

DOE Office of Scientific and Technical Information (OSTI.GOV)

Natzkov, S.; Nikolov, M.

1995-12-01

The design life of the main power equipment-boilers and turbines is about 105 working hours. The possibilities for life extension are after normatively regulated control tests. The diagnostics and methodology for Boilers and Turbines Elements Remaining Life Assessment using up to date computer programs, destructive and nondestructive control of metal of key elements of units equipment, metal creep and low cycle fatigue calculations. As well as data for most common damages and some technical decisions for elements life extension are presented.

A comparison of the structural strength between fiberglass and jute fiber in the Acehnese Traditional Boat Jalo Kayoh using finite element method

NASA Astrophysics Data System (ADS)

Akram; Hasanuddin, Iskandar; Nazaruddin; Syahril Anwar, M.; Zulfan; Ahmad, Norhafizan

2018-05-01

The Acehnese traditional boat, known as Jalo Kayoh, is a mean of transportation used by Acehnese fishermen. The main constituent of the boat is wood. However, due to the decline of high-quality wood supply and as a preventative measure of illegal logging, fiberglass and jute fiber are used instead of wood. This study compares the strength of the two materials using finite element method. The Jalo Kayoh model plan stands at 4m in length, 0.6 m in width, and 0.4 m in height. A 2500 N static load is applied to the surface, using a C3D10 quadratic tetrahedron 0.02 mesh. The result of the simulation to the fiberglass is a maximum displacement of 7.123 x 10-5m, while the jute fiber has a maximum displacement of 2.255 x 10-4 m. The maximum stress stands at 1.612 x 106 Pa for the fiberglass and 1.523 x 106 Pa for the jute fiber. The maximum strain occurs at 1.654 x 10-5 for the fiberglass and 4.581 x 10-5 for the jute fiber. To conclude, fiber glass has more stress 1.05 % and less strain 2.76 % than jute fiber and both the materials can sustain the load given.

Trace element geochemistry of volcanic gases and particles from 1983-1984 eruptive episodes of Kilauea Volcano

NASA Astrophysics Data System (ADS)

Crowe, Bruce M.; Finnegan, David L.; Zoller, William H.; Boynton, William V.

1987-12-01

Compositional data have been obtained for volcanic gases and particles collected from fume emitted at the Pu'u O'o vent on the east rift zone of Kilauea volcano. The samples were collected by pumping fume through a filter pack system consisting of a front stage particulate filter followed by four base-treated filters (7LiOH). Particles and condensed phases are trapped on the particulate filter, and acidic gases are collected on the treated filters. The filters are analyzed for 30 elements by instrumental neutron activation analysis. Fume samples were collected from the Pu'u O'o vent for two eruptive episodes: (1) 7 days after episode 11 (cooling vent samples) and (2) the waning stage of episode 13 (active vent samples). Additional samples were collected by aircraft from the gas plume released during the lava fountaining phase of episode 17 (aircraft samples). Element concentrations in the vent gases were > 104 μg m-3 for S, Cl, and F. Enrichment factors (EFs) for the volcanic fume versus the source magma were calculated using the volatile element Br as the reference element for normalization and the U.S. Geological Survey standard BHVO-1 as the magma standard. This removes the ash dilution effect obtained by using an ash constituent (Al, Sc, or Mg) as the reference element. Bromine-normalized EFs (× 105) range from 101 to 102 for Na, K, and Cu; 102 to 105 for Zn, W, Sb, In, Ir, Ag, F, and As; and > 105 for Au, Cd, Re, Cl, Se, and S. The highest enrichment factors are for aircraft samples collected during the most gas-rich phase of an eruption cycle. Metal and volatile-element data form two groups: (1) elements showing little or no variation in abundance ratios with sample type (group 1: Cl, Br, and Re) and (2) elements that show significant variation in abundance ratios by sample type (group 2: Zn, W, Sb, In, Ir, Au, and Cd). Bivariate plots of elements of the first group versus elements of the second group separate by sample type. The separation corresponds to samples collected during eruptive activity versus samples collected during repose periods. Monitoring trace metal ratios in volcanic fume could provide an additional tool for predicting volcanic eruptions. The F/Cl ratio of cooling vent samples is higher than those of active vent or aircraft samples, and the ratio is inversely correlated with EFs for most volatile metals.

17 CFR 256.123 - Investment in associate companies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Investment in associate companies. 256.123 Section 256.123 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 2. Investments § 256.123 Investment in associate companies. This...

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommendations for assuring facility development. 256.42 Section 256.42 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan...

17 CFR 256.123 - Investment in associate companies.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Investment in associate companies. 256.123 Section 256.123 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 2. Investments § 256.123 Investment in associate companies. This...

32 CFR 256.7 - Accident potential zone guidelines.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Accident potential zone guidelines. 256.7 Section 256.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS AIR INSTALLATIONS COMPATIBLE USE ZONES § 256.7 Accident potential zone guidelines...

40 CFR 256.31 - Recommendations for developing and implementing resource conservation and recovery programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... implementing resource conservation and recovery programs. 256.31 Section 256.31 Protection of Environment... SOLID WASTE MANAGEMENT PLANS Resource Conservation and Resource Recovery Programs § 256.31 Recommendations for developing and implementing resource conservation and recovery programs. (a) In order to...

17 CFR 256.01-6 - Departmental classification required.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Departmental classification required. 256.01-6 Section 256.01-6 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-6 Departmental classification required...

32 CFR 256.7 - Accident potential zone guidelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Accident potential zone guidelines. 256.7 Section 256.7 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS AIR INSTALLATIONS COMPATIBLE USE ZONES § 256.7 Accident potential zone guidelines...

25 CFR 256.4 - Information Collection.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Information Collection. 256.4 Section 256.4 Indians... Information Collection. The information collection requirements contained in § 256.9 have been approved by the... information is collected to determine applicant eligibility for services and eligibility to participate in the...

17 CFR 256.310 - Aircraft and airport equipment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Aircraft and airport equipment. 256.310 Section 256.310 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 Service Company Property Accounts § 256.310 Aircraft and airport...

17 CFR 256.310 - Aircraft and airport equipment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Aircraft and airport equipment. 256.310 Section 256.310 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... UTILITY HOLDING COMPANY ACT OF 1935 Service Company Property Accounts § 256.310 Aircraft and airport...

The Use of Sparse Direct Solver in Vector Finite Element Modeling for Calculating Two Dimensional (2-D) Magnetotelluric Responses in Transverse Electric (TE) Mode

NASA Astrophysics Data System (ADS)

Yihaa Roodhiyah, Lisa’; Tjong, Tiffany; Nurhasan; Sutarno, D.

2018-04-01

The late research, linear matrices of vector finite element in two dimensional(2-D) magnetotelluric (MT) responses modeling was solved by non-sparse direct solver in TE mode. Nevertheless, there is some weakness which have to be improved especially accuracy in the low frequency (10-3 Hz-10-5 Hz) which is not achieved yet and high cost computation in dense mesh. In this work, the solver which is used is sparse direct solver instead of non-sparse direct solverto overcome the weaknesses of solving linear matrices of vector finite element metod using non-sparse direct solver. Sparse direct solver will be advantageous in solving linear matrices of vector finite element method because of the matrix properties which is symmetrical and sparse. The validation of sparse direct solver in solving linear matrices of vector finite element has been done for a homogen half-space model and vertical contact model by analytical solution. Thevalidation result of sparse direct solver in solving linear matrices of vector finite element shows that sparse direct solver is more stable than non-sparse direct solver in computing linear problem of vector finite element method especially in low frequency. In the end, the accuracy of 2D MT responses modelling in low frequency (10-3 Hz-10-5 Hz) has been reached out under the efficient allocation memory of array and less computational time consuming.

Magnetization and magnetoresistance of common alloy wires used in cryogenic instrumentation.

PubMed

Abrecht, M; Adare, A; Ekin, J W

2007-04-01

We present magnetization and magnetoresistance data at liquid-helium and liquid-nitrogen temperatures for wire materials commonly used for instrumentation wiring of specimens, sensors, and heaters in cryogenic probes. The magnetic susceptibilities in Systeme International units at 4.2 K were found to be: Manganin 1.25x10(-2), Nichrome 5.6x10(-3), and phosphor bronze -3.3x10(-5), indicating that phosphor bronze is the most suitable for high-field applications. We also show the ferromagnetic hysteresis loop of Constantan wire at liquid-helium temperature. The magnetoresistance of these four wires was relatively small: the changes in resistance at 4 K due to a 10 T transverse magnetic field are -2.56% for Constantan, -2.83% for Manganin, +0.69% for Nichrome, and +4.5% for phosphor bronze, compared to about +188% for a typical copper wire under the same conditions.

Magnetization and magnetoresistance of common alloy wires used in cryogenic instrumentation

NASA Astrophysics Data System (ADS)

Abrecht, M.; Adare, A.; Ekin, J. W.

2007-04-01

We present magnetization and magnetoresistance data at liquid-helium and liquid-nitrogen temperatures for wire materials commonly used for instrumentation wiring of specimens, sensors, and heaters in cryogenic probes. The magnetic susceptibilities in Systeme International units at 4.2 K were found to be: Manganin 1.25×10-2, Nichrome 5.6×10-3, and phosphor bronze -3.3×10-5, indicating that phosphor bronze is the most suitable for high-field applications. We also show the ferromagnetic hysteresis loop of Constantan wire at liquid-helium temperature. The magnetoresistance of these four wires was relatively small: the changes in resistance at 4 K due to a 10 T transverse magnetic field are -2.56% for Constantan, -2.83% for Manganin, +0.69% for Nichrome, and +4.5% for phosphor bronze, compared to about +188% for a typical copper wire under the same conditions.

Characterization of microstructural, mechanical and thermophysical properties of Th-52U alloy

NASA Astrophysics Data System (ADS)

Das, Santanu; Kaity, S.; Kumar, R.; Banerjee, J.; Roy, S. B.; Chaudhari, G. P.; Daniel, B. S. S.

2016-11-01

Th-52 wt.% U alloy has a microstructure featuring interspersed networks of uranium rich and thorium rich phases. Room temperature hardness of the alloy is more than twice that of unalloyed thorium. The alloy age hardens (550 °C) only slightly (peak hardness/hardness of solution heated and quenched = 1.05). Room temperature thermal conductivity (25.6 W m-1 °C-1) is close to that of uranium and most of the binary and ternary metallic alloy fuel materials. Average linear coefficient of thermal expansion (CTE) of Th-52 wt.% U alloy [11.2 × 10-06 °C-1 (27-290 °C) and 16.75 × 10-06 °C-1 (27-600 °C)] are comparable with that of many metallic alloy fuel candidates. Th-52 wt.% U alloy with non-age hardenable microstructure, appreciable thermal conductivity, moderate thermal expansion may find metallic fuel applications in nuclear reactors.

30 CFR 256.2 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Policy. 256.2 Section 256.2 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.2 Policy...

24 CFR 25.6 - Violations creating grounds for administrative action.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Violations creating grounds for administrative action. 25.6 Section 25.6 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development MORTGAGEE REVIEW BOARD § 25.6 Violations creating grounds for administrative...

30 CFR 256.71 - Directional drilling.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Directional drilling. 256.71 Section 256.71..., and Extensions § 256.71 Directional drilling. In accordance with an approved exploration plan or development and production plan, a lease may be maintained in force by directional wells drilled under the...

40 CFR 25.6 - Public meetings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Public meetings. 25.6 Section 25.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC PARTICIPATION IN PROGRAMS UNDER THE RESOURCE CONSERVATION AND RECOVERY ACT, THE SAFE DRINKING WATER ACT, AND THE CLEAN WATER ACT § 25.6 Public...

17 CFR 256.188 - Research, development, or demonstration expenditures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Research, development, or demonstration expenditures. 256.188 Section 256.188 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 4. Deferred Debits § 256.188 Research, development, or...

30 CFR 256.71 - Directional drilling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Directional drilling. 256.71 Section 256.71... OIL AND GAS IN THE OUTER CONTINENTAL SHELF Assignments, Transfers, and Extensions § 256.71 Directional drilling. In accordance with an approved exploration plan or development and production plan, a lease may...

30 CFR 256.71 - Directional drilling.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Directional drilling. 256.71 Section 256.71... LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Assignments, Transfers, and Extensions § 256.71 Directional drilling. In accordance with a BOEM-approved exploration plan or development and...

30 CFR 256.71 - Directional drilling.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Directional drilling. 256.71 Section 256.71... LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Assignments, Transfers, and Extensions § 256.71 Directional drilling. In accordance with a BOEM-approved exploration plan or development and...

30 CFR 256.71 - Directional drilling.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Directional drilling. 256.71 Section 256.71... LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Assignments, Transfers, and Extensions § 256.71 Directional drilling. In accordance with a BOEM-approved exploration plan or development and...

17 CFR 256.01-2 - Application to service companies doing business with nonassociate companies.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-2 Application to service companies doing business with nonassociate companies. While this... companies doing business with nonassociate companies. 256.01-2 Section 256.01-2 Commodity and Securities...

40 CFR 81.256 - Northeast Iowa Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Northeast Iowa Intrastate Air Quality Control Region. 81.256 Section 81.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.256 Northeast Iowa Intrastate Air Quality Control Region. The Northeast Iowa...

25 CFR 256.12 - Who administers the Housing Improvement Program?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Who administers the Housing Improvement Program? 256.12 Section 256.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.12 Who administers the Housing Improvement Program? The Housing Improvement Program is...

25 CFR 256.12 - Who administers the Housing Improvement Program?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Who administers the Housing Improvement Program? 256.12 Section 256.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.12 Who administers the Housing Improvement Program? The Housing Improvement Program is...

25 CFR 256.12 - Who administers the Housing Improvement Program?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Who administers the Housing Improvement Program? 256.12 Section 256.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.12 Who administers the Housing Improvement Program? The Housing Improvement Program is...

25 CFR 256.12 - Who administers the Housing Improvement Program?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Who administers the Housing Improvement Program? 256.12 Section 256.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.12 Who administers the Housing Improvement Program? The Housing Improvement Program is...

25 CFR 256.12 - Who administers the Housing Improvement Program?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Who administers the Housing Improvement Program? 256.12 Section 256.12 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.12 Who administers the Housing Improvement Program? The Housing Improvement Program is...

Pstl repeat: a family of short interspersed nucleotide element (SINE)-like sequences in the genomes of cattle, goat, and buffalo.

PubMed

Sheikh, Faruk G; Mukhopadhyay, Sudit S; Gupta, Prabhakar

2002-02-01

The PstI family of elements are short, highly repetitive DNA sequences interspersed throughout the genome of the Bovidae. We have cloned and sequenced some members of the PstI family from cattle, goat, and buffalo. These elements are approximately 500 bp, have a copy number of 2 x 10(5) - 4 x 10(5), and comprise about 4% of the haploid genome. Studies of nucleotide sequence homology indicate that the buffalo and goat PstI repeats (type II) are similar types of short interspersed nucleotide element (SINE) sequences, but the cattle PstI repeat (type I) is considerably more divergent. Additionally, the goat PstI sequence showed significant sequence homology with bovine serine tRNA, and is therefore likely derived from serine tRNA. Interestingly, Southern hybridization suggests that both types of SINEs (I and II) are present in all the species of Bovidae. Dendrogram analysis indicates that cattle PstI SINE is similar to bovine Alu-like SINEs. Goat and buffalo SINEs formed a separate cluster, suggesting that these two types of SINEs evolved separately in the genome of the Bovidae.

Second-generation detector work in Israel

NASA Astrophysics Data System (ADS)

Rosenfeld, David

2001-10-01

A tremendous developmental effort in the field of infrared detectors during the last decade in Israel has resulted in a variety of InSb and HgCdTe infrared detectors. Additional and significant R&D effort associated with other IR components, have also been done in Israel, in order to integrate the detectors into advanced Detector-Dewar-Cooler assemblies (DDCs). This R&D effort included notable activities in the field of materials, signal processors, dewars and cryocoolers. These activities are presented together with the status of infrared detector work in Israel. Several two-dimensional InSb staring detectors and DDCs are demonstrated. This includes two versions of the classical 256 X 256 detectors and DDCs, improved 640 X 480 InSb detectors and DDC, and a 2000- element detector with high TDI level. SADA II type HgCdTe detectors are also presented. Considerations regarding the course of future detector work are also described. The classical DDC requirement list which traditionally included demands for high D*, low NETD and high resolution is widened to include cost related issues such as higher reliability, lower maintenance, smaller volume, lower power consumption and higher operation temperature.

New Fragment Separation Technology for Superheavy Element Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaughnessy, D A; Moody, K J; Henderson, R A

2008-01-28

This project consisted of three major research areas: (1) development of a solid Pu ceramic target for the MASHA separator, (2) chemical separation of nuclear decay products, and (3) production of new isotopes and elements through nuclear reactions. There have been 16 publications as a result of this project, and this collection of papers summarizes our accomplishments in each of the three areas of research listed above. The MASHA (Mass Analyzer for Super-Heavy Atoms) separator is being constructed at the U400 Cyclotron at the Flerov Laboratory of Nuclear Reactions in Dubna, Russia. The purpose of the separator is to physicallymore » separate the products from nuclear reactions based on their isotopic masses rather than their decay characteristics. The separator was designed to have a separation between isotopic masses of {+-}0.25 amu, which would enable the mass of element 114 isotopes to be measured with outstanding resolution, thereby confirming their discovery. In order to increase the production rate of element 114 nuclides produced via the {sup 244}Pu+{sup 48}Ca reaction, a new target technology was required. Instead of a traditional thin actinide target, the MASHA separator required a thick, ceramic-based Pu target that was thick enough to increase element 114 production while still being porous enough to allow reaction products to migrate out of the target and travel through the separator to the detector array located at the back end. In collaboration with UNLV, we began work on development of the Pu target for MASHA. Using waste-form synthesis technology, we began by creating zirconia-based matrices that would form a ceramic with plutonium oxide. We used samarium oxide as a surrogate for Pu and created ceramics that had varying amounts of the starting materials in order to establish trends in material density and porosity. The results from this work are described in more detail in Refs. [1,4,10]. Unfortunately, work on MASHA was delayed in Russia because it was found that the efficiency of transporting products from the target chamber to the detector array was much too low for applications in heavy element experiments where production rates are on the order of one atom per day or less. Work continues on the MASHA separator, and once the efficiency has been improved, we plan to continue our work on the Pu target for future element 114 experiments. Due to the delays of the MASHA separator, work on establishing the identity of heavy element species produced through nuclear reactions focused instead on chemical separations. In particular, element 115 decays through a series of alpha decays, terminating with an element 105 isotope with a long half-life ({approx} 1 day). By chemically separating the element 105 daughter and observing its subsequent fission decay, the identity of the original parent nucleus can be established through the genetic correlation of the initial series of alpha decays. Chemical separations of element 105 were developed in Switzerland, Russia, and at LLNL. Over the course of two experiments, reaction products from the {sup 243}Am+{sup 48}Ca reaction were collected in a copper block and subsequently processed for chemical separation of the Group Five elements [8,9,13,15]. The Group Five elements were initially separated from the Group Four species, and then the samples were sub-divided into tantalum and niobium fractions. All of the fission events were observed in the tantalum fractions, which implied that element 105 behaved more like tantalum under the chemical conditions of these experiments. These experiments were very successful, and not only demonstrated that chemical separation could be performed on single atoms of interest, but also lent proof to the identity of the parent nucleus as element 115. Subsequent analysis of the alpha spectra taken during the experiment further prove that the fission events observed during the two experiments came from element 105 as the decay daughter of element 115 and could not attributed to interference from other background species [16]. The final aspect of this project was the production of new isotopes and elements. All of the experiments were performed in Dubna at the U400 Cyclotron and the results are described in more detail in Refs. [2,3,5-8,11,12,14]. The first experiments were designed to establish the decay properties of isotopes of elements 112, 114, and 116 [5]. Because these isotopic signatures were established through these initial experiments, the discovery of element 118 [11] was possible, since the 118 nuclides decayed into these previously studied isotopes. This was the first successful report of the discovery of element 118, which was reported by the media to a large extent. The last experiment that was performed for this project was the production and detection of a new isotope of element 113 [14].« less

27 CFR 24.256 - Bottle aging wine.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Bottle aging wine. 24.256 Section 24.256 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... of Wine § 24.256 Bottle aging wine. Wine bottled or packed and stored for the purpose of aging need...

27 CFR 24.256 - Bottle aging wine.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Bottle aging wine. 24.256 Section 24.256 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... of Wine § 24.256 Bottle aging wine. Wine bottled or packed and stored for the purpose of aging need...

27 CFR 24.256 - Bottle aging wine.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Bottle aging wine. 24.256 Section 24.256 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... of Wine § 24.256 Bottle aging wine. Wine bottled or packed and stored for the purpose of aging need...

27 CFR 24.256 - Bottle aging wine.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Bottle aging wine. 24.256 Section 24.256 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... of Wine § 24.256 Bottle aging wine. Wine bottled or packed and stored for the purpose of aging need...

42 CFR 84.256 - Quality control requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in paragraphs...

42 CFR 84.256 - Quality control requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in paragraphs...

42 CFR 84.256 - Quality control requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in paragraphs...

42 CFR 84.256 - Quality control requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in paragraphs...

42 CFR 84.256 - Quality control requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in paragraphs...

30 CFR 256.25 - Areas near coastal States.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Areas near coastal States. 256.25 Section 256... SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Call for Information and Nominations § 256.25 Areas near coastal States. (a) At the time information is solicited for leasing of areas within 3...

30 CFR 256.50 - Dating of leases.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Dating of leases. 256.50 Section 256.50 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Issuance of Leases § 256.50 Dating of leases. All leases issued under...

30 CFR 256.82 - Environmental studies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Environmental studies. 256.82 Section 256.82... INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Studies § 256.82 Environmental studies. (a) The Director shall conduct a study of any area or region included in any lease sale...

30 CFR 256.82 - Environmental studies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Environmental studies. 256.82 Section 256.82... OIL AND GAS IN THE OUTER CONTINENTAL SHELF Studies § 256.82 Environmental studies. (a) The Director shall conduct a study of any area or region included in any lease sale in order to establish information...

24 CFR 203.256 - Insurance of open-end advance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance of open-end advance. 203.256 Section 203.256 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 203.256 Insurance of open-end advance. Insurance on an open-end advance will be evidenced by...

24 CFR 203.256 - Insurance of open-end advance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Insurance of open-end advance. 203.256 Section 203.256 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 203.256 Insurance of open-end advance. Insurance on an open-end advance will be evidenced by...

24 CFR 203.256 - Insurance of open-end advance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Insurance of open-end advance. 203.256 Section 203.256 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 203.256 Insurance of open-end advance. Insurance on an open-end advance will be evidenced by...

24 CFR 203.256 - Insurance of open-end advance.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Insurance of open-end advance. 203.256 Section 203.256 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 203.256 Insurance of open-end advance. Insurance on an open-end advance will be evidenced by...

24 CFR 203.256 - Insurance of open-end advance.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Insurance of open-end advance. 203.256 Section 203.256 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 203.256 Insurance of open-end advance. Insurance on an open-end advance will be evidenced by...

17 CFR 256.01-7 - Records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Records. 256.01-7 Section 256... COMPANY ACT OF 1935 General Instructions § 256.01-7 Records. (a) The books of account and other records of... identification and audit. (b) The books and records referred to herein shall include not only accounting records...

17 CFR 256.01-7 - Records.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Records. 256.01-7 Section 256... COMPANY ACT OF 1935 General Instructions § 256.01-7 Records. (a) The books of account and other records of... identification and audit. (b) The books and records referred to herein shall include not only accounting records...

30 CFR 256.63 - Service fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Service fees. 256.63 Section 256.63 Mineral... IN THE OUTER CONTINENTAL SHELF Assignments, Transfers, and Extensions § 256.63 Service fees. (a) The table in this paragraph (a) shows the fees that you must pay to MMS for the services listed. The fees...

40 CFR 256.02 - Scope of the State solid waste management plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., General Requirements, Definitions § 256.02 Scope of the State solid waste management plan. (a)(1) The... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Scope of the State solid waste management plan. 256.02 Section 256.02 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

40 CFR 256.02 - Scope of the State solid waste management plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., General Requirements, Definitions § 256.02 Scope of the State solid waste management plan. (a)(1) The... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Scope of the State solid waste management plan. 256.02 Section 256.02 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

40 CFR 256.02 - Scope of the State solid waste management plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., General Requirements, Definitions § 256.02 Scope of the State solid waste management plan. (a)(1) The... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Scope of the State solid waste management plan. 256.02 Section 256.02 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

40 CFR 256.02 - Scope of the State solid waste management plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., General Requirements, Definitions § 256.02 Scope of the State solid waste management plan. (a)(1) The... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Scope of the State solid waste management plan. 256.02 Section 256.02 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

40 CFR 256.02 - Scope of the State solid waste management plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., General Requirements, Definitions § 256.02 Scope of the State solid waste management plan. (a)(1) The... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Scope of the State solid waste management plan. 256.02 Section 256.02 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...

30 CFR 256.80 - Leases of other minerals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Leases of other minerals. 256.80 Section 256.80 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Section 6 Leases § 256.80 Leases of other minerals. The...

Clinical Trial of AC105 (Mg/PEG) for Treatment of Acute Spinal Cord Injury (SCI). Phase 2

DTIC Science & Technology

2013-10-01

glycol with a molecular weight of 3350 Daltons ( PEG 3350 ), is manufactured by Dow Chemical Company and complies with NF, FCC and EurPh requirements...Mg/ PEG ) for Treatment of Acute Spinal Cord Injury (SCI) PRINCIPAL INVESTIGATOR: Andrew Blight, PhD RECIPIENT: Acorda Therapeutics...of AC105 (Mg/ PEG ) for Treatment of Acute Spinal Cord Injury (SCI) 5b. GRANT NUMBER W81XWH-12-2 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

Vertical Mixing In Western Lake Constance Due To Long Internal Waves

NASA Astrophysics Data System (ADS)

Boehrer, B.

Current profiles in the pelagic waters of western Lake Constance have been broken up into modes of the internal wave equation [1,2]. All current profiles can be well represented by a combination of the first and second mode wave. The temporal vari- ation of the modal composition with the interaction of the first and second mode im- plies current shear at varying depths. From current and density profiles, the gradient Richardson number can be evaluated in its spatial and temporal pattern with occa- tional occurence of supercritical values at all depths, also in the deep hypolimnion. An empiric connection between gradient Richardson number and diapycnical mixing [3] is applied to yield a profile of vertical transport coefficients, which can be com- pared with transport coefficients from gradient flux calculations of temperature and electrical conductivity profiles [4]. [1] B. Boehrer, J. Ilmberger and K.O. Münnich (2000): Vertical Structure of Current in Western Lake Constance, JGR-Oceans, 105 (12), 28823-28835 [2] B. Boehrer (2000): Modal Response of a Deep Stratified Lake: Western Lake Con- stance, JGR-Oceans, 105 (12), 28837-28845 [3] H. Peeters, M.C. Gregg and J.M. Toole (1988): On the parameterization of equa- torial turbulence, JGR, 93, 1199-1218 [4] G. Heinz, J. Ilmberger and M. Schimmele (1990): Vertical Mixing in Überlinger See, western part of Lake Constance, Aquat. Sci., 52(3), 256-268

Predictive value of GSTP1 Ile105Val polymorphism in clinical outcomes of chemotherapy in gastric and colorectal cancers: a systematic review and meta-analysis.

PubMed

Shen, Xiaobing; Wang, Jia; Yan, Xiaoluan; Ren, Xiaofeng; Wang, Fan; Chen, Xiaowei; Xu, Yuchao

2016-06-01

Gastric and colorectal cancers remain the major causes of cancer-related death with a bad prognosis. Up to now, platinum combined with fluoropyrimidines has been most commonly used in chemotherapy regimens of gastric and colorectal cancers. Recently, a series of studies have been conducted to investigate the associations of biomarkers, such as GSTP1 Ile105Val polymorphism, with the chemotherapy efficacy in gastric and colorectal cancers; however, the results were not consistent and inconclusive. Here, we performed a systematic review and meta-analysis to summarize the associations of GSTP1 Ile105Val polymorphism with the chemotherapy efficacy in gastric and colorectal cancers. A systematic review was conducted to search relevant studies in English databases (PubMed, ISI Web of Science, and EMBASE) up to November 30, 2015. The pooling ORs or HRs were used to assess the strength of the associations of GSTP1 Ile105Val polymorphism with clinical outcomes such as tumor response, toxicity, progression-free survival (PFS), and overall survival (OS). Forty-one papers containing 8169 cases were finally included in the present meta-analysis study. Of which, 28 articles were performed in colorectal cancers, one in gastrointestinal carcinoma (gastric and colon cancer), 11 in gastric cancers, and one in colorectal and gastroesophageal cancers. After pooling all the eligible studies, we identified significant associations of GSTP1 Ile105Val polymorphism with chemotherapy-related tumor response (G vs. A: OR 1.697, 95 % CI 1.191-2.418; GG vs. AA: OR 2.804, 95 % CI 1.414-5.560; AG vs. AA: OR 1.540, 95 % CI 1.011-2.347; GG vs. AAAG: OR 2.139, 95 % CI 1.256-3.641), PFS (GG vs. AA, HR 0.640, 95 % CI 0.455-0.900; AGGG vs. AA: HR 0.718, 95 % CI 0.562-0.919), and OS (AG vs. AA: HR 0.857, 95 % CI 0.746-0.986; GG vs. AA: HR 0.679, 95 % CI 0.523-0.882; AGGG vs. AA: HR 0.663, 95 % CI 0.542-0.812) in gastric and colorectal cancers and no significant association was found between the polymorphism with toxicity. GSTP1 Ile105Val polymorphism was associated with tumor response, PFS, and OS in gastric and colorectal cancers after chemotherapy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vinuesa, Ricardo; Fick, Lambert; Negi, Prabal

In the present document we describe a toolbox for the spectral-element code Nek5000, aimed at computing turbulence statistics. The toolbox is presented for a small test case, namely a square duct with L x = 2h, L y = 2h and L z = 4h, where x, y and z are the horizontal, vertical and streamwise directions, respectively. The number of elements in the xy-plane is 16 X 16 = 256, and the number of elements in z is 4, leading to a total of 1,204 spectral elements. A polynomial order of N = 5 is chosen, and the meshmore » is generated using the Nek5000 tool genbox. The toolbox presented here allows to compute mean-velocity components, the Reynolds-stress tensor as well as turbulent kinetic energy (TKE) and Reynolds-stress budgets. Note that the present toolbox allows to compute turbulence statistics in turbulent flows with one homogeneous direction (where the statistics are based on time-averaging as well as averaging in the homogeneous direction), as well as in fully three-dimensional flows (with no periodic directions, where only time-averaging is considered).« less

Sensor Agent Processing Software (SAPS)

DTIC Science & Technology

2004-05-01

buildings, sewers, and tunnels. The time scale governs many aspects of tactical sensing. In high intensity combat situations forces move within...21 Figure 9-2 BAE Systems Sitex00 High Bandwidth...float) Subscribers Subscribers Preprocessor Channel 1 xout[256] Data File in Memory xout[256] S w i t c h High Pass Filter (IIR) xin[256] xout[256

Providing Cryptographic Security and Evidentiary Chain-of-Custody with the Advanced Forensic Format, Library, and Tools

DTIC Science & Technology

2008-08-19

1 hash of the page page%d sha256 The segment for the SHA256 hash of the page Bad Sector Management: badsectors The number of sectors in the image...written, AFFLIB can automatically compute the page’s MD5, SHA-1, and/or SHA256 hash and write an associated segment containing the hash value. The...are written into segments themselves, with the segment name being name/ sha256 where name is the original segment name sha256 is the hash algorithm used

MSTI-3 sensor package optical design

NASA Astrophysics Data System (ADS)

Horton, Richard F.; Baker, William G.; Griggs, Michael; Nguyen, Van; Baker, H. Vernon

1995-06-01

The MSTI-3 sensor package is a three band imaging telescope for military and dual use sensing missions. The MSTI-3 mission is one of the Air Force Phillips Laboratory's Pegasus launched space missions, a third in the series of state-of-the-art lightweight sensors on low cost satellites. The satellite is planned for launch into a 425 Km orbit in late 1995. The MSTI- 3 satellite is configured with a down looking two axis gimbal and gimbal mirror. The gimbal mirror is an approximately 13 cm by 29 cm mirror which allows a field of regard approximately 100 degrees by 180 degrees. The optical train uses several novel optical features to allow for compactness and light weight. A 105 mm Ritchey Chretien Cassegrain imaging system with a CaF(subscript 2) dome astigmatism corrector is followed by a CaF(subscript 2) beamsplitter cube assembly at the systems first focus. The dichroic beamsplitter cube assembly separates the light into a visible and two IR channels of approximately 2.5 to 3.3, (SWIR), and 3.5 to 4.5, (MWIR), micron wavelength bands. The two IR imaging channels each consist of unity power re-imaging lens cluster, a cooled seven position filter wheel, a cooled Lyot stop and an Amber 256 X 256 InSb array camera. The visible channel uses a unity power re- imaging system prior to a linear variable filter with a Sony CCD array, which allows for a multispectral imaging capability in the 0.5 to 0.8 micron region. The telescope field of view is 1.4 degrees square.

31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

Code of Federal Regulations, 2011 CFR

2011-07-01

... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

Code of Federal Regulations, 2010 CFR

2010-07-01

... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

Code of Federal Regulations, 2012 CFR

2012-07-01

... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

Code of Federal Regulations, 2014 CFR

2014-07-01

... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

31 CFR 256.13 - Are agencies required to supply a taxpayer identification number (TIN) when submitting a request...

Code of Federal Regulations, 2013 CFR

2013-07-01

... taxpayer identification number (TIN) when submitting a request for payment? 256.13 Section 256.13 Money and... BILLS Requesting Payments § 256.13 Are agencies required to supply a taxpayer identification number (TIN) when submitting a request for payment? Yes, agencies must include a valid TIN on all requests for...

25 CFR 256.28 - What can I do if I disagree with actions taken under the Housing Improvement Program?

Code of Federal Regulations, 2010 CFR

2010-04-01

... Housing Improvement Program? 256.28 Section 256.28 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.28 What can I do if I disagree with actions taken under the Housing Improvement Program? You may appeal action or inaction by an official of the Bureau of...

The magnetic field and the evolution of element spots on the surface of the HgMn eclipsing binary ARAur

NASA Astrophysics Data System (ADS)

Hubrig, S.; Savanov, I.; Ilyin, I.; González, J. F.; Korhonen, H.; Lehmann, H.; Schöller, M.; Granzer, T.; Weber, M.; Strassmeier, K. G.; Hartmann, M.; Tkachenko, A.

2010-10-01

The system ARAur is a young late B-type double-lined eclipsing binary with a primary star of HgMn peculiarity. We applied the Doppler imaging method to reconstruct the distribution of Fe and Y over the surface of the primary using spectroscopic time series obtained in 2005 and from 2008 October to 2009 February. The results show a remarkable evolution of the element distribution and overabundances. Measurements of the magnetic field with the moment technique using several elements reveal the presence of a longitudinal magnetic field of the order of a few hundred gauss in both stellar components and a quadratic field of the order of 8kG on the surface of the primary star. Based on observations obtained at the 2.56-m Nordic Optical Telescope on La Palma, the Karl-Schwarzschild-Observatorium in Tautenburg and the STELLA robotic telescope on Tenerife. E-mail: shubrig@aip.de

25 CFR 256.20 - How are these repairs or construction trades persons, home building contractors, or construction...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false How are these repairs or construction trades persons, home building contractors, or construction companies selected and paid? 256.20 Section 256.20 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.20 How are these repairs or construction trades persons...

Restriction fragment length polymorphism markers associated with silk maysin, antibiosis to corn earworm (Lepidoptera: Noctuidae) larvae, in a dent and sweet corn cross.

PubMed

Guo, B Z; Zhang, Z J; Li, R G; Widstrom, N W; Snook, M E; Lynch, R E; Plaisted, D

2001-04-01

Maysin, a C-glycosylflavone in maize silk, has insecticidal activity against corn earworm, Helicoverpa zea (Boddie), larvae. Sweet corn, Zea mays L., is a vulnerable crop to ear-feeding insects and requires pesticide protection from ear damage. This study was conducted to identify maize chromosome regions associated with silk maysin concentration and eventually to transfer and develop high silk maysin sweet corn lines with marker-assisted selection (MAS). Using an F2 population derived from SC102 (high maysin dent corn) and B31857 (low maysin sh2 sweet corn), we detected two major quantitative trait loci (QTL). It was estimated that 25.6% of the silk maysin variance was associated with segregation in the genomic region of npi286 (flanking to p1) on chromosome 1S. We also demonstrated that a1 on chromosome 3L had major contribution to silk maysin (accounted for 15.7% of the variance). Locus a1 has a recessive gene action for high maysin with the presence of functional p1 allele. Markers umc66a (near c2) and umc105a on chromosome 9S also were detected in this analysis with minor contribution. A multiple-locus model, which included npi286, a1, csu3 (Bin 1.05), umc245 (Bin 7.05), agrr21 (Bin 8.09), umc105a, and the epistatic interactions npi286 x a1, a1 x agrr21, csu3 x umc245, and umc105a x umc245, accounted for 76.3% of the total silk maysin variance. Tester crosses showed that at the a1 locus, SC102 has functional A1 alleles and B31857 has homozygous recessive a1 alleles. Individuals of (SC102 x B31857) x B31857 were examined with MAS and plants with p1 allele from SC102 and homozygous a1 alleles from B31857 had consistent high silk maysin. Marker-assisted selection seems to be a suitable method to transfer silk maysin to sweet corn lines to reduce pesticide application.

Osteoporosis‐like Changes in Walker Carcinoma 256‐Bearing Rats, Not Accompanied with Hypercalcemia or Parathyroid Hormone‐related Protein Production

PubMed Central

Waki, Yoshihiro; Kasugai, Shohei; Ohya, Keiichi

1995-01-01

Walker carcinoma 256 (W256) was reported to induce hypercalcemia dependent on bone metastasis and/or parathyroid hormone‐related protein (PTHrP) in the rat, providing a model of the humoral hypercalcemia of malignancy. In this study, after the subcutaneous inoculation of cells of the W256/S line, which is maintained in this laboratory, into young female Wistar Imamichi rats (6 weeks old), serum calcium and phosphorus levels changed only within the control range, whereas serum alkaline phosphatase activity and urinary calcium level significantly increased and urinary phosphorus decreased during the tumor growth, resulting in hypercalciuria and hypophosphaturia. W256/S did not express PTHrP‐mRNA, whereas LLC‐W256 cells did express it. Serum PTHrP level was not changed in W256/S‐bearing rats. Osteoporosis‐like changes, bone weight loss, low contents of bone calcium and phosphorus, and a decrease in the bone mineral density (BMD), were observed in the femur 14 days after the tumor inoculation. There was a pronounced decrease in the serum 17β‐estradiol level during the tumor growth. The reduction of BMD of femurs in W256/S‐bearing rats was significantly inhibited by treatment with salmon calcitonin or 17β‐estradiol. On the basis of these results, W256/S carcinoma‐bearing rats seem to be a useful model for osteoporosis of hypoovarianism. PMID:7540609

High-performance parallel processors based on star-coupled wavelength division multiplexing optical interconnects

DOEpatents

Deri, Robert J.; DeGroot, Anthony J.; Haigh, Ronald E.

2002-01-01

As the performance of individual elements within parallel processing systems increases, increased communication capability between distributed processor and memory elements is required. There is great interest in using fiber optics to improve interconnect communication beyond that attainable using electronic technology. Several groups have considered WDM, star-coupled optical interconnects. The invention uses a fiber optic transceiver to provide low latency, high bandwidth channels for such interconnects using a robust multimode fiber technology. Instruction-level simulation is used to quantify the bandwidth, latency, and concurrency required for such interconnects to scale to 256 nodes, each operating at 1 GFLOPS performance. Performance scales have been shown to .apprxeq.100 GFLOPS for scientific application kernels using a small number of wavelengths (8 to 32), only one wavelength received per node, and achievable optoelectronic bandwidth and latency.

Theoretical predictions of properties and gas-phase chromatography behaviour of bromides of group-5 elements Nb, Ta, and element 105, Db.

PubMed

Pershina, V; Anton, J

2012-01-21

Fully relativistic, four-component density functional theory electronic structure calculations were performed for MBr(5), MOBr(3), MBr(6)(-), KMBr(6), and MBr(5)Cl(-) of group-5 elements Nb, Ta, and element 105, Db, with the aim to predict adsorption behaviour of the bromides in gas-phase chromatography experiments. It was shown that in the atmosphere of HBr/BBr(3), the pentabromides are rather stable, and their stability should increase in the row Nb < Db < Ta. Several mechanisms of adsorption were considered. In the case of adsorption by van der Waals forces, the sequence in volatility of the pentabromides should be Nb < Ta < Db, being in agreement with the sublimation enthalpies of the Nb and Ta pentabromides. In the case of adsorption by chemical forces (on a quartz surface modified with KBr∕KCl), formation of the MBr(5)L(-) (L = Cl, Br) complex should occur, so that the volatility should change in an opposite way, i.e., Nb > Ta > Db. This sequence is in agreement with the one observed in the "one-atom-at-a-time" chromatography experiments. Some other scenarios, such as surface oxide formation were also considered but found to be irrelevant. © 2012 American Institute of Physics

Image Filtering with Boolean and Statistical Operators.

DTIC Science & Technology

1983-12-01

S3(2) COMPLEX AMAT(256, 4). BMAT (256. 4). CMAT(256. 4) CALL IOF(3. MAIN. AFLNM. DFLNI, CFLNM. MS., 82, S3) CALL OPEN(1.AFLNM* 1.IER) CALL CHECKC!ER...RDBLK(2. 6164. MAT. 16, IER) CALL CHECK(IER) DO I K-1. 4 DO I J-1.256 CMAT(J. K)-AMAT(J. K)’. BMAT (J. K) I CONTINUE S CALL WRBLK(3. 164!. CMAT. 16. IER

Finite element fatigue analysis of rectangular clutch spring of automatic slack adjuster

NASA Astrophysics Data System (ADS)

Xu, Chen-jie; Luo, Zai; Hu, Xiao-feng; Jiang, Wen-song

2015-02-01

The failure of rectangular clutch spring of automatic slack adjuster directly affects the work of automatic slack adjuster. We establish the structural mechanics model of automatic slack adjuster rectangular clutch spring based on its working principle and mechanical structure. In addition, we upload such structural mechanics model to ANSYS Workbench FEA system to predict the fatigue life of rectangular clutch spring. FEA results show that the fatigue life of rectangular clutch spring is 2.0403×105 cycle under the effect of braking loads. In the meantime, fatigue tests of 20 automatic slack adjusters are carried out on the fatigue test bench to verify the conclusion of the structural mechanics model. The experimental results show that the mean fatigue life of rectangular clutch spring is 1.9101×105, which meets the results based on the finite element analysis using ANSYS Workbench FEA system.

High-frame rate multiport CCD imager and camera

NASA Astrophysics Data System (ADS)

Levine, Peter A.; Patterson, David R.; Esposito, Benjamin J.; Tower, John R.; Lawler, William B.

1993-01-01

A high frame rate visible CCD camera capable of operation up to 200 frames per second is described. The camera produces a 256 X 256 pixel image by using one quadrant of a 512 X 512 16-port, back illuminated CCD imager. Four contiguous outputs are digitally reformatted into a correct, 256 X 256 image. This paper details the architecture and timing used for the CCD drive circuits, analog processing, and the digital reformatter.

Micromachining Techniques in Developing High-Frequency Piezoelectric Composite Ultrasonic Array Transducers

PubMed Central

Liu, Changgeng; Djuth, Frank T.; Zhou, Qifa; Shung, K. Kirk

2014-01-01

Several micromachining techniques for the fabrication of high-frequency piezoelectric composite ultrasonic array transducers are described in this paper. A variety of different techniques are used in patterning the active piezoelectric material, attaching backing material to the transducer, and assembling an electronic interconnection board for transmission and reception from the array. To establish the feasibility of the process flow, a hybrid test ultrasound array transducer consisting of a 2-D array having an 8 × 8 element pattern and a 5-element annular array was designed, fabricated, and assessed. The arrays are designed for a center frequency of ~60 MHz. The 2-D array elements are 105 × 105 μm in size with 5-μm kerfs between elements. The annular array surrounds the square 2-D array and provides the option of transmitting from the annular array and receiving with the 2-D array. Each annular array element has an area of 0.71 mm2 with a 16-μm kerf between elements. The active piezoelectric material is (1 − x) Pb(Mg1/3Nb2/3)O3−xPbTiO3 (PMN-PT)/epoxy 1–3 composite with a PMN-PT pillar lateral dimension of 8 μm and an average gap width of ~4 μm, which was produced by deep reactive ion etching (DRIE) dry etching techniques. A novel electric interconnection strategy for high-density, small-size array elements was proposed. After assembly, the array transducer was tested and characterized. The capacitance, pulse–echo responses, and crosstalk were measured for each array element. The desired center frequency of ~60 MHz was achieved and the −6-dB bandwidth of the received signal was ~50%. At the center frequency, the crosstalk between adjacent 2-D array elements was about −33 dB. The techniques described herein can be used to build larger arrays containing smaller elements. PMID:24297027

Review of Recent BABAR Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lista, L.

2004-12-02

We present a review of recent results from BaBar experiment. BaBar detector has collected about 256 millions of B{bar B} events at PEP-II, the asymmetric e{sup +}e{sup -} collider located at SLAC running at the {Upsilon}(4S) resonance. We have studied CP violation in B mesons, observing the first evidence of direct CP violation in B meson decays and measured CP asymmetries relevant for the determination of the angles of the CKM Unitarity Triangle. BaBar physics program covers many other topics, including measurements of CKM matrix elements, charm physics, and search for new physics processes.

40 CFR 256.25 - Recommendation for inactive facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... notification of agencies responsible for public health and safety. ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommendation for inactive facilities. 256.25 Section 256.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

40 CFR 256.25 - Recommendation for inactive facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... notification of agencies responsible for public health and safety. ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommendation for inactive facilities. 256.25 Section 256.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

40 CFR 256.25 - Recommendation for inactive facilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... notification of agencies responsible for public health and safety. ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommendation for inactive facilities. 256.25 Section 256.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID...

78 FR 58601 - Notice of Request for the Extension of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-24

... (TEA-21), Public Law 105-85, as amended by the Safe, Accountable, Flexible, Efficient, Transportation.... These services are an important element of the U.S. transportation system. TEA-21 authorized FTA's OTRB...

The development of infrared detectors and mechanisms for use in future infrared space missions

NASA Technical Reports Server (NTRS)

Houck, James R.

1995-01-01

The environment above earth's atmosphere offers significant advantages in sensitivity and wavelength coverage in infrared astronomy over ground-based observatories. In support of future infrared space missions, technology development efforts were undertaken to develop detectors sensitive to radiation between 2.5 micron and 200 micron. Additionally, work was undertaken to develop mechanisms supporting the imaging and spectroscopy requirements of infrared space missions. Arsenic-doped-Silicon and Antimony-doped-Silicon Blocked Impurity Band detectors, responsive to radiation between 4 micron and 45 micron, were produced in 128x128 picture element arrays with the low noise, high sensitivity performance needed for space environments. Technology development continued on Gallium-doped-Germanium detectors (for use between 80 micron and 200 micron), but were hampered by contamination during manufacture. Antimony-doped-Indium detectors (for use between 2.5 micron and 5 micron) were developed in a 256x256 pixel format with high responsive quantum efficiency and low dark current. Work began on adapting an existing cryogenic mechanism design for space-based missions; then was redirected towards an all-fixed optical design to improve reliability and lower projected mission costs.

Bioinspired architecture approach for a one-billion transistor smart CMOS camera chip

NASA Astrophysics Data System (ADS)

Fey, Dietmar; Komann, Marcus

2007-05-01

In the paper we present a massively parallel VLSI architecture for future smart CMOS camera chips with up to one billion transistors. To exploit efficiently the potential offered by future micro- or nanoelectronic devices traditional on central structures oriented parallel architectures based on MIMD or SIMD approaches will fail. They require too long and too many global interconnects for the distribution of code or the access to common memory. On the other hand nature developed self-organising and emergent principles to manage successfully complex structures based on lots of interacting simple elements. Therefore we developed a new as Marching Pixels denoted emergent computing paradigm based on a mixture of bio-inspired computing models like cellular automaton and artificial ants. In the paper we present different Marching Pixels algorithms and the corresponding VLSI array architecture. A detailed synthesis result for a 0.18 μm CMOS process shows that a 256×256 pixel image is processed in less than 10 ms assuming a moderate 100 MHz clock rate for the processor array. Future higher integration densities and a 3D chip stacking technology will allow the integration and processing of Mega pixels within the same time since our architecture is fully scalable.

The GONG Data Reduction and Analysis System. [solar oscillations

NASA Technical Reports Server (NTRS)

Pintar, James A.; Andersen, Bo Nyborg; Andersen, Edwin R.; Armet, David B.; Brown, Timothy M.; Hathaway, David H.; Hill, Frank; Jones, Harrison P.

1988-01-01

Each of the six GONG observing stations will produce three, 16-bit, 256X256 images of the Sun every 60 sec of sunlight. These data will be transferred from the observing sites to the GONG Data Management and Analysis Center (DMAC), in Tucson, on high-density tapes at a combined rate of over 1 gibabyte per day. The contemporaneous processing of these data will produce several standard data products and will require a sustained throughput in excess of 7 megaflops. Peak rates may exceed 50 megaflops. Archives will accumulate at the rate of approximately 1 terabyte per year, reaching nearly 3 terabytes in 3 yr of observing. Researchers will access the data products with a machine-independent GONG Reduction and Analysis Software Package (GRASP). Based on the Image Reduction and Analysis Facility, this package will include database facilities and helioseismic analysis tools. Users may access the data as visitors in Tucson, or may access DMAC remotely through networks, or may process subsets of the data at their local institutions using GRASP or other systems of their choice. Elements of the system will reach the prototype stage by the end of 1988. Full operation is expected in 1992 when data acquisition begins.

Continued improvement in reduced-mode (REM) diodes enable 272 W from 105 μm 0.15 NA beam

NASA Astrophysics Data System (ADS)

Kanskar, M.; Bao, L.; Chen, Z.; Dawson, D.; DeVito, M.; Dong, W.; Grimshaw, M.; Guan, X.; Hemenway, M.; Martinsen, R.; Urbanek, W.; Zhang, S.

2017-02-01

High-power, high-brightness diode lasers from 8xx nm to 9xx nm have been pursued in many applications including fiber laser pumping, materials processing, solid-state laser pumping, and consumer electronics manufacturing. In particular, 915 nm - 976 nm diodes are of interest as diode pumps for the kilowatt CW fiber lasers. Thus, there have been many technical efforts on driving the diode lasers to have both high power and high brightness to achieve high-performance and reduced manufacturing costs. This paper presents our continued progress in the development of high brightness fiber-coupled product platform, elementTM. In the past decade, the amount of power coupled into a single 105 μm and 0.15 NA fiber has increased by over a factor of ten through improved diode laser brilliance and the development of techniques for efficiently coupling multiple emitters into a single fiber. In this paper, we demonstrate the further brightness improvement and power-scaling enabled by both the rise in chip brightness/power and the increase in number of chips coupled into a given numerical aperture. We report a new x-REM design with brightness as high as 4.3 W/mm-mrad at a BPP of 3 mm-mrad. We also report the record 272W from a 2×9 elementTM with 105 μm/0.15 NA beam using x-REM diodes and a new product introduction at 200W output power from 105 μm/0.15 NA beam at 915 nm.

Improvement in reduced-mode (REM) diodes enable 315 W from 105-μm 0.15-NA fiber-coupled modules

NASA Astrophysics Data System (ADS)

Kanskar, M.; Bao, L.; Chen, Z.; Dawson, D.; DeVito, M.; Dong, W.; Grimshaw, M.; Guan, X.; Hemenway, M.; Martinsen, R.; Urbanek, W.; Zhang, S.

2018-02-01

High-power, high-brightness diode lasers have been pursued for many applications including fiber laser pumping, materials processing, solid-state laser pumping, and consumer electronics manufacturing. In particular, 915 nm - and 976 nm diodes are of interest as diode pumps for the kilowatt CW fiber lasers. As a result, there have been many technical thrusts for driving the diode lasers to have both high power and high brightness to achieve high-performance and reduced manufacturing costs. This paper presents our continued progress in the development of high brightness fiber-coupled product platform, nLIGHT element®. In the past decade, the power coupled into a single 105 μm and 0.15 NA fiber has increased by over a factor of ten through improved diode laser brightness and the development of techniques for efficiently coupling multiple emitters. In this paper, we demonstrate further brightness improvement and power-scaling enabled by both the rise in chip brightness/power and the increase in number of chips coupled into a given numerical aperture. We report a new chip technology using x-REM design with brightness as high as 4.3 W/mm-mrad at a BPP of 3 mm-mrad. We also report record 315 W output from a 2×12 nLIGHT element with 105 μm diameter fiber using x-REM diodes and these diodes will allow next generation of fiber-coupled product capable of 250W output power from 105 μm/0.15 NA beam at 915 nm.

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2010 CFR

2010-07-01

... development. 256.42 Section 256.42 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility... unrestricted movement of solid and hazardous waste across State and local boundaries. ...

40 CFR 256.65 - Recommendations for public participation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... participation. 256.65 Section 256.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Public... designed to encourage informed public participation in the development and implementation of solid waste...

17 CFR 256.931 - Rents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Rents. 256.931 Section 256.931 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS..., computers, data processing equipment, micro-wave and telecommunication equipment, airplanes, automobiles...

Toward imaging the body at 10.5 tesla.

PubMed

Ertürk, M Arcan; Wu, Xiaoping; Eryaman, Yiğitcan; Van de Moortele, Pierre-François; Auerbach, Edward J; Lagore, Russell L; DelaBarre, Lance; Vaughan, J Thomas; Uğurbil, Kâmil; Adriany, Gregor; Metzger, Gregory J

2017-01-01

To explore the potential of performing body imaging at 10.5 Tesla (T) compared with 7.0T through evaluating the transmit/receive performance of similarly configured dipole antenna arrays. Fractionated dipole antenna elements for 10.5T body imaging were designed and evaluated using numerical simulations. Transmit performance of antenna arrays inside the prostate, kidneys and heart were investigated and compared with those at 7.0T using both phase-only radiofrequency (RF) shimming and multi-spoke pulses. Signal-to-noise ratio (SNR) comparisons were also performed. A 10-channel antenna array was constructed to image the abdomen of a swine at 10.5T. Numerical methods were validated with phantom studies at both field strengths. Similar power efficiencies were observed inside target organs with phase-only shimming, but RF nonuniformity was significantly higher at 10.5T. Spokes RF pulses allowed similar transmit performance with accompanying local specific absorption rate increases of 25-90% compared with 7.0T. Relative SNR gains inside the target anatomies were calculated to be >two-fold higher at 10.5T, and 2.2-fold SNR gain was measured in a phantom. Gradient echo and fast spin echo imaging demonstrated the feasibility of body imaging at 10.5T with the designed array. While comparable power efficiencies can be achieved using dipole antenna arrays with static shimming at 10.5T; increasing RF nonuniformities underscore the need for efficient, robust, and safe parallel transmission methods. Magn Reson Med 77:434-443, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Ahmed glaucoma valve in eyes with preexisting episcleral encircling element.

PubMed

Choudhari, Nikhil Shreeram; George, Ronnie; Shantha, Balekudaru; Neog, Aditya; Tripathi, Shweta; Srinivasan, Bhaskar; Vijaya, Lingam

2014-05-01

To describe the use of Ahmed glaucoma valve (AGV) in the management of intractable glaucoma in eyes with a preexisting episcleral encircling element. This is a retrospective, consecutive, noncomparative study. The study included 12 eyes of 12 patients with a preexisting episcleral encircling element that underwent implantation of silicone AGV to treat intractable glaucoma during January 2009 to September 2010. The mean patient age was 25.6 (standard deviation 17.1) years. Five (41.6%) patients were monocular. The indications for AGV were varied. The mean duration between placement of episcleral encircling element and implantation of AGV was 30.5 (33.8) months. The mean follow-up was 37.4 (22.9) weeks. Preoperatively, the mean intraocular pressure (IOP) was 31.4 (7.9) mmHg and the mean antiglaucoma medications were 2.8. At the final postoperative follow-up, the mean IOP was 12.5 (3.5) mmHg and the mean number of antiglaucoma medications was 0.8 (P < 0.001). The complications observed over the follow-up period did include corneal graft failure in three eyes, tube erosion in two eyes and rhegmatogenous retinal detachment in one eye. AGV is an effective option in the management of intractable glaucoma in eyes with a preexisting episcleral encircling element keeping in mind the possibility of significant postoperative complications.

17 CFR 256.301 - Organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Organization. 256.301 Section 256.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM... service company such as stock, minute books and corporate seal. Note: This account shall not include any...

17 CFR 256.301 - Organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Organization. 256.301 Section 256.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM... service company such as stock, minute books and corporate seal. Note: This account shall not include any...

40 CFR 256.25 - Recommendation for inactive facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommendation for inactive facilities. 256.25 Section 256.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.25 - Recommendation for inactive facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommendation for inactive facilities. 256.25 Section 256.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

17 CFR 256.303 - Miscellaneous intangible plant.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Miscellaneous intangible plant. 256.303 Section 256.303 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... plant. (a) This account shall include the cost of patent rights, licenses, privileges, and other...

17 CFR 256.216 - Unappropriated retained earnings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... retained earnings. This account shall include the balance, either debit or credit, arising from earnings... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Unappropriated retained earnings. 256.216 Section 256.216 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

Some aspects of adaptive transform coding of multispectral data

NASA Technical Reports Server (NTRS)

Ahmed, N.; Natarajan, T.

1977-01-01

This paper concerns a data compression study pertaining to multi-spectral scanner (MSS) data. The motivation for this undertaking is the need for securing data compression of images obtained in connection with the Landsat Follow-On Mission, where a compression of at least 6:1 is required. The MSS data used in this study consisted of four scenes: Tristate, consisting of 256 pels per row and a total of 512 rows - i.e., (256x512), (2) Sacramento (256x512), (3) Portland (256x512), and (4) Bald Knob (200x256). All these scenes were on digital tape at 6 bits/pel. The corresponding reconstructed scenes of 1 bit/pel (i.e., a 6:1 compression) are included.

40 CFR 256.22 - Recommendations for State regulatory powers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommendations for State regulatory powers. 256.22 Section 256.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.22 - Recommendations for State regulatory powers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommendations for State regulatory powers. 256.22 Section 256.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.21 - Requirements for State regulatory powers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for State regulatory powers. 256.21 Section 256.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.21 - Requirements for State regulatory powers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for State regulatory powers. 256.21 Section 256.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.21 - Requirements for State regulatory powers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for State regulatory powers. 256.21 Section 256.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.22 - Recommendations for State regulatory powers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommendations for State regulatory powers. 256.22 Section 256.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

17 CFR 256.426.1 - Donations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Donations. 256.426.1 Section... COMPANY ACT OF 1935 Income and Expense Accounts § 256.426.1 Donations. This account shall include all payments or donations for charitable, social or community welfare purposes. ...

17 CFR 256.426.1 - Donations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Donations. 256.426.1 Section... COMPANY ACT OF 1935 Income and Expense Accounts § 256.426.1 Donations. This account shall include all payments or donations for charitable, social or community welfare purposes. ...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 25.6 - Public meetings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Public meetings. 25.6 Section 25.6... meetings. Public meetings are any assemblies or gathering, (such as conferences, informational sessions... to attend. Public meetings are less formal than public hearings. They do not require formal...

Plate-shaped non-contact ultrasonic transporter using flexural vibration.

PubMed

Ishii, Takahiko; Mizuno, Yosuke; Koyama, Daisuke; Nakamura, Kentaro; Harada, Kana; Uchida, Yukiyoshi

2014-02-01

We developed a plate-shaped non-contact transporter based on ultrasonic vibration, exploiting a phenomenon that a plate can be statically levitated at the place where its gravity and the acoustic radiation force are balanced. In the experiment, four piezoelectric zirconate titanate elements were attached to aluminum plates, on which lattice flexural vibration was excited at 22.3 kHz. The vibrating plates were connected to a loading plate via flexible posts that can minimize the influence of the flexure induced by heavy loads. The distribution of the vibration displacement on the plate was predicted through finite-element analysis to find the appropriate positions of the posts. The maximum levitation height of this transporter was 256 μm with no load. When two vibrating plates were connected to a loading plate, the maximum transportable load was 4.0 kgf. Copyright © 2013. Published by Elsevier B.V.

Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016

PubMed Central

Scott, Janet T.; Baxter, Julia M.; Parkes, Craig K.; Dwivedi, Rahul; Czanner, Gabriela; Vandy, Matthew J.; Momorie, Fayiah; Fornah, Alimamy D.; Komba, Patrick; Richards, Jade; Sahr, Foday; Beare, Nicholas A.V.; Semple, Malcolm G.

2017-01-01

We conducted a case–control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%–85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%–87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%–16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%–25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry. PMID:28628441

Chemical composition, antioxidant properties and anti-cholinesterase activity of Cordia gilletii (Boraginaceae) leaves essential oil.

PubMed

Bonesi, Marco; Okusa, Philippe N; Tundis, Rosa; Loizzo, Monica R; Menichini, Federica; Stévigny, Caroline; Duez, Pierre; Menichini, Francesco

2011-02-01

This study aimed to investigate for the first time the chemical composition, the antioxidant properties and the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of the essential oil from the leaves of Cordia gilletii De Wild (Boraginaceae). The essential oil, characterized by 23 constituents (90.1% of the total oil), was constituted by terpene derivatives (25.6%) and non-terpene derivatives (64.5%), among which aldehydes, fatty acids and alkanes were present with the percentage of 16.5%, 18.8% and 23.1%, respectively. The antioxidant activity of C. gilletii essential oil was screened by two in vitro tests: DPPH and beta-carotene bleaching test. The essential oil revealed antioxidant activity with an IC50 value of 75.0 and 129.9 microg/mL on DPPH radical and beta-carotene decoloration tests, respectively. Moreover, C. gilletii inhibited AChE enzyme with an IC50 value of 105.6 microg/mL.

Carbon nanotubes based vacuum gauge

NASA Astrophysics Data System (ADS)

Rudyk, N. N.; Il'in, O. I.; Il'ina, M. V.; Fedotov, A. A.; Klimin, V. S.; Ageev, O. A.

2017-11-01

We have created an ionization type Vacuum gauge with sensor element based on an array of vertically aligned carbon nanotubes. Obtained asymmetrical current-voltage characteristics at different voltage polarity on the electrode with the CNTs. It was found that when applying a negative potential on an electrode with the CNTs, the current in the gap is higher than at a positive potential. In the pressure range of 1 ÷ 103 Torr vacuum gauge sensitivity was 6 mV/Torr (at a current of 4.5·10-5 A) and in the range of 10-5 ÷ 1 Torr was 10 mV/Torr (at a current of 1.3·10-5 A). It is shown that the energy efficiency of vacuum gauge can be increased in the case where electrode with CNT operates as an emitter of electrons.

Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study.

PubMed

Kunutsor, Setor Kwadzo; Whitehouse, Michael Richard; Blom, Ashley William; Laukkanen, Jari Antero

2017-07-01

Magnesium, which is an essential trace element that plays a key role in several cellular processes, is a major component of bone; however, its relationship with risk of major bone fractures is uncertain. We aimed to investigate the association of baseline serum magnesium concentrations with risk of incident fractures. We analyzed data on 2245 men aged 42-61 years in the Kuopio Ischemic Heart Disease prospective cohort study, with the assessment of serum magnesium measurements and dietary intakes made at baseline. Hazard ratios [95% confidence intervals (CI)] for incident total (femoral, humeral, and forearm) and femoral fractures were assessed. During a median follow-up of 25.6 years, 123 total fractures were recorded. Serum magnesium was non-linearly associated with risk of total fractures. In age-adjusted Cox regression analysis, the hazard ratio (HR) (95% CIs) for total fractures in a comparison of the bottom quartile versus top quartile of magnesium concentrations was 2.10 (1.30-3.41), which persisted on adjustment for several established risk factors 1.99 (1.23-3.24). The association remained consistent on further adjustment for renal function, socioeconomic status, total energy intake, and several trace elements 1.80 (1.10-2.94). The corresponding adjusted HRs for femoral fractures were 2.56 (1.38-4.76), 2.43 (1.30-4.53) and 2.13 (1.13-3.99) respectively. There was no evidence of an association of dietary magnesium intake with risk of any fractures. In middle-aged Caucasian men, low serum magnesium is strongly and independently associated with an increased risk of fractures. Further research is needed to assess the potential relevance of serum magnesium in the prevention of fractures.

Next generation miniature simultaneous multi-hyperspectral imaging systems

NASA Astrophysics Data System (ADS)

Hinnrichs, Michele; Gupta, Neelam

2014-03-01

The concept for a hyperspectral imaging system using a Fabry-Perot tunable filter (FPTF) array that is fabricated using "miniature optical electrical mechanical system" (MOEMS) technology. [1] Using an array of FPTF as an approach to hyperspectral imaging relaxes wavelength tuning requirements considerably because of the reduced portion of the spectrum that is covered by each element in the array. In this paper, Pacific Advanced Technology and ARL present the results of a concept design and performed analysis of a MOEMS based tunable Fabry-Perot array (FPTF) to perform simultaneous multispectral and hyperspectral imaging with relatively high spatial resolution. The concept design was developed with support of an Army SBIR Phase I program The Fabry-Perot tunable MOEMS filter array was combined with a miniature optics array and a focal plane array of 1024 x 1024 pixels to produce 16 colors every frame of the camera. Each color image has a spatial resolution of 256 x 256 pixels with an IFOV of 1.7 mrads and FOV of 25 degrees. The spectral images are collected simultaneously allowing high resolution spectral-spatial-temporal information in each frame of the camera, thus enabling the implementation of spectral-temporal-spatial algorithms in real-time to provide high sensitivity for the detection of weak signals in a high clutter background environment with low sensitivity to camera motion. The challenge in the design was the independent actuation of each Fabry Perot element in the array allowing for individual tuning. An additional challenge was the need to maximize the fill factor to improve the spatial coverage with minimal dead space. This paper will only address the concept design and analysis of the Fabry-Perot tunable filter array. A previous paper presented at SPIE DSS in 2012 explained the design of the optical array.

The effect of electronically steering a phased array ultrasound transducer on near-field tissue heating.

PubMed

Payne, Allison; Vyas, Urvi; Todd, Nick; de Bever, Joshua; Christensen, Douglas A; Parker, Dennis L

2011-09-01

This study presents the results obtained from both simulation and experimental techniques that show the effect of mechanically or electronically steering a phased array transducer on proximal tissue heating. The thermal response of a nine-position raster and a 16-mm diameter circle scanning trajectory executed through both electronic and mechanical scanning was evaluated in computer simulations and experimentally in a homogeneous tissue-mimicking phantom. Simulations were performed using power deposition maps obtained from the hybrid angular spectrum (HAS) method and applying a finite-difference approximation of the Pennes' bioheat transfer equation for the experimentally used transducer and also for a fully sampled transducer to demonstrate the effect of acoustic window, ultrasound beam overlap and grating lobe clutter on near-field heating. Both simulation and experimental results show that electronically steering the ultrasound beam for the two trajectories using the 256-element phased array significantly increases the thermal dose deposited in the near-field tissues when compared with the same treatment executed through mechanical steering only. In addition, the individual contributions of both beam overlap and grating lobe clutter to the near-field thermal effects were determined through comparing the simulated ultrasound beam patterns and resulting temperature fields from mechanically and electronically steered trajectories using the 256-randomized element phased array transducer to an electronically steered trajectory using a fully sampled transducer with 40 401 phase-adjusted sample points. Three distinctly different three distinctly different transducers were simulated to analyze the tradeoffs of selected transducer design parameters on near-field heating. Careful consideration of design tradeoffs and accurate patient treatment planning combined with thorough monitoring of the near-field tissue temperature will help to ensure patient safety during an MRgHIFU treatment.

17 CFR 256.124 - Other investments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Other investments. 256.124... COMPANY ACT OF 1935 2. Investments § 256.124 Other investments. This account shall include the cost or current value of investments, whichever is less, in securities, club memberships, associations, life...

40 CFR 256.24 - Recommendations for closing or upgrading open dumps.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommendations for closing or upgrading open dumps. 256.24 Section 256.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS...

40 CFR 256.24 - Recommendations for closing or upgrading open dumps.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommendations for closing or upgrading open dumps. 256.24 Section 256.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.24 - Recommendations for closing or upgrading open dumps.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommendations for closing or upgrading open dumps. 256.24 Section 256.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

17 CFR 256.124 - Other investments.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Other investments. 256.124... COMPANY ACT OF 1935 2. Investments § 256.124 Other investments. This account shall include the cost or current value of investments, whichever is less, in securities, club memberships, associations, life...

30 CFR 256.12 - Supplemental sales.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Supplemental sales. 256.12 Section 256.12 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management...

30 CFR 256.2 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Policy. 256.2 Section 256.2 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and...

17 CFR 256.01-8 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-8 Definitions. Definitions contained in the Public... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definitions. 256.01-8 Section...

15 CFR 256.2 - The Research Associate Program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific...

15 CFR 256.2 - The Research Associate Program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific...

30 CFR 256.26 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false General. 256.26 Section 256.26 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS... for environmental analysis and consideration for leasing. The Director, on his/her own motion, may...

17 CFR 256.01-13 - Submission of questions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Submission of questions. 256.01-13 Section 256.01-13 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... interpretation of the prescribed accounting to the Division of Corporate Regulation or its successor for...

15 CFR 256.2 - The Research Associate Program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false The Research Associate Program. 256.2... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES RESEARCH ASSOCIATE PROGRAM § 256.2 The Research Associate Program. The Bureau provides its facilities, scientific...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

17 CFR 256.01-3 - General structure of accounting system.

Code of Federal Regulations, 2010 CFR

2010-04-01

... accounting system. 256.01-3 Section 256.01-3 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE... accounting system. (a) The accounts provided herein are in two general categories: Balance sheet accounts and...

30 CFR 256.29 - Proposed notice of sale.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Proposed notice of sale. 256.29 Section 256.29 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE... measures, including lease stipulations and conditions, to mitigate adverse impacts on the environments. For...

40 CFR 256.31 - Recommendations for developing and implementing resource conservation and recovery programs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommendations for developing and implementing resource conservation and recovery programs. 256.31 Section 256.31 Protection of Environment... are identified. These studies should review various technological approaches, environmental...

40 CFR 256.31 - Recommendations for developing and implementing resource conservation and recovery programs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommendations for developing and implementing resource conservation and recovery programs. 256.31 Section 256.31 Protection of Environment... are identified. These studies should review various technological approaches, environmental...

40 CFR 256.31 - Recommendations for developing and implementing resource conservation and recovery programs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommendations for developing and implementing resource conservation and recovery programs. 256.31 Section 256.31 Protection of Environment... are identified. These studies should review various technological approaches, environmental...

40 CFR 256.31 - Recommendations for developing and implementing resource conservation and recovery programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommendations for developing and implementing resource conservation and recovery programs. 256.31 Section 256.31 Protection of Environment... are identified. These studies should review various technological approaches, environmental...

Curriculum Design Issues in Developing a Doctor of Philosophy Program in Aeronology.

ERIC Educational Resources Information Center

Johnson, Jeffrey A.

1997-01-01

Aviation education institutions (75 of 105 surveyed) expressed their preferences for the elements of a Ph.D. program in aeronology (nonengineering aerospace/aeronautical sciences). A research/practitioner model, core curriculum, and second area of specialization were supported. (SK)

49 CFR 195.256 - Crossing of railroads and highways.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 3 2010-10-01 2010-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

40 CFR 256.41 - Recommendations for assessing the need for facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommendations for assessing the need for facilities. 256.41 Section 256.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... their impact on facility needs should be assessed. (3) Current and projected movement of solid and...

40 CFR 256.41 - Recommendations for assessing the need for facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommendations for assessing the need for facilities. 256.41 Section 256.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... their impact on facility needs should be assessed. (3) Current and projected movement of solid and...

17 CFR 256.236 - Taxes accrued.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Taxes accrued. 256.236 Section... COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.236 Taxes accrued. (a) This account shall be credited with the amount of taxes accrued during the accounting period, corresponding debits being made to...

40 CFR 256.64 - Requirements for public participation in the open dump inventory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for public participation in the open dump inventory. 256.64 Section 256.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.63 - Requirements for public participation in the permitting of facilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for public participation in the permitting of facilities. 256.63 Section 256.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.64 - Requirements for public participation in the open dump inventory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for public participation in the open dump inventory. 256.64 Section 256.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.61 - Requirements for public participation in the annual State work program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for public participation in the annual State work program. 256.61 Section 256.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.23 - Requirements for closing or upgrading open dumps.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for closing or upgrading open dumps. 256.23 Section 256.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid...

40 CFR 256.64 - Requirements for public participation in the open dump inventory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for public participation in the open dump inventory. 256.64 Section 256.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.61 - Requirements for public participation in the annual State work program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for public participation in the annual State work program. 256.61 Section 256.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.63 - Requirements for public participation in the permitting of facilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for public participation in the permitting of facilities. 256.63 Section 256.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.23 - Requirements for closing or upgrading open dumps.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for closing or upgrading open dumps. 256.23 Section 256.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid...

40 CFR 256.61 - Requirements for public participation in the annual State work program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for public participation in the annual State work program. 256.61 Section 256.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.63 - Requirements for public participation in the permitting of facilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for public participation in the permitting of facilities. 256.63 Section 256.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.61 - Requirements for public participation in the annual State work program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for public participation in the annual State work program. 256.61 Section 256.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.23 - Requirements for closing or upgrading open dumps.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for closing or upgrading open dumps. 256.23 Section 256.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid...

40 CFR 256.64 - Requirements for public participation in the open dump inventory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for public participation in the open dump inventory. 256.64 Section 256.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.63 - Requirements for public participation in the permitting of facilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for public participation in the permitting of facilities. 256.63 Section 256.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

30 CFR 256.8 - Leasing maps and diagrams.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Leasing maps and diagrams. 256.8 Section 256.8 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management...

30 CFR 256.10 - Information to States.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Information to States. 256.10 Section 256.10 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management...

40 CFR 256.05 - Annual work program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Annual work program. 256.05 Section..., Definitions § 256.05 Annual work program. (a) The annual work program submitted for financial assistance under... Administrator and the State shall agree on the contents of the annual work program. The Administrator will...

40 CFR 256.05 - Annual work program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Annual work program. 256.05 Section..., Definitions § 256.05 Annual work program. (a) The annual work program submitted for financial assistance under... Administrator and the State shall agree on the contents of the annual work program. The Administrator will...

47 CFR 15.214 - Cordless telephones.

Code of Federal Regulations, 2010 CFR

2010-10-01

... discrete digital codes. Factory-set codes must be continuously varied over at least 256 possible codes as... readily select from among at least 256 possible discrete digital codes. The cordless telephone shall be... fixed code that is continuously varied among at least 256 discrete digital codes as each telephone is...

17 CFR 256.108 - Accumulated provision for depreciation and amortization of service company property.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., unless the company maintains costs and related reserves for specific units or types of property. (c... depreciation and amortization of service company property. 256.108 Section 256.108 Commodity and Securities... COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Balance Sheet...

49 CFR 195.256 - Crossing of railroads and highways.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

49 CFR 195.256 - Crossing of railroads and highways.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

49 CFR 195.256 - Crossing of railroads and highways.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

49 CFR 195.256 - Crossing of railroads and highways.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Crossing of railroads and highways. 195.256... TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.256 Crossing of railroads and highways. The pipe at each railroad or highway crossing must be installed so as to adequately withstand the dynamic...

40 CFR 256.64 - Requirements for public participation in the open dump inventory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for public participation in the open dump inventory. 256.64 Section 256.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.61 - Requirements for public participation in the annual State work program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for public participation in the annual State work program. 256.61 Section 256.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.60 - Requirements for public participation in State and substate plans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for public participation in State and substate plans. 256.60 Section 256.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

17 CFR 256.920 - Salaries and wages.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Salaries and wages. 256.920... COMPANY ACT OF 1935 2. Expense § 256.920 Salaries and wages. (a) This account shall include salaries, wages, bonuses and other consideration for services, with the exception of director's fees paid directly...

17 CFR 256.411 - Provision for deferred income taxes-credit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... taxes-credit. 256.411 Section 256.411 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... deferred income taxes—credit. This account shall be credited and Accumulated Deferred Income Taxes debited with an amount equal to the portion of taxes on income payable for the year which is attributable to a...

17 CFR 256.255 - Accumulated deferred investment tax credits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... investment tax credits. 256.255 Section 256.255 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... investment tax credits. (a) This account shall be credited and account 411.5, Investment tax credit, debited with investment tax credits deferred by companies which do not apply such credits as a reduction of the...

28 CFR 25.6 - Accessing records in the system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Accessing records in the system. 25.6 Section 25.6 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The...) Search the relevant databases (i.e., NICS Index, NCIC, III) for any matching records; and (iv) Provide...

28 CFR 25.6 - Accessing records in the system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Accessing records in the system. 25.6 Section 25.6 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The...) Search the relevant databases (i.e., NICS Index, NCIC, III) for any matching records; and (iv) Provide...

28 CFR 25.6 - Accessing records in the system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Accessing records in the system. 25.6 Section 25.6 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The...) Search the relevant databases (i.e., NICS Index, NCIC, III) for any matching records; and (iv) Provide...

28 CFR 25.6 - Accessing records in the system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Accessing records in the system. 25.6 Section 25.6 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The...) Search the relevant databases (i.e., NICS Index, NCIC, III) for any matching records; and (iv) Provide...

17 CFR 256.135 - Working funds.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Working funds. 256.135 Section... COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.135 Working funds. This account shall include cash advanced to officers, agents, employees and others as petty cash or working funds. ...

17 CFR 256.135 - Working funds.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Working funds. 256.135 Section... COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.135 Working funds. This account shall include cash advanced to officers, agents, employees and others as petty cash or working funds. ...

40 CFR 60.256 - Continuous monitoring requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

....256 Section 60.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... rates of 25 Mg (28 tons) per year or more, a bag leak detection system according to the requirements in... performance test on an operating day average basis. (c) Each bag leak detection system used to comply with...

40 CFR 60.256 - Continuous monitoring requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

....256 Section 60.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... rates of 25 Mg (28 tons) per year or more, a bag leak detection system according to the requirements in... performance test on an operating day average basis. (c) Each bag leak detection system used to comply with...

40 CFR 60.256 - Continuous monitoring requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

....256 Section 60.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... rates of 25 Mg (28 tons) per year or more, a bag leak detection system according to the requirements in... performance test on an operating day average basis. (c) Each bag leak detection system used to comply with...

40 CFR 60.256 - Continuous monitoring requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

....256 Section 60.256 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... rates of 25 Mg (28 tons) per year or more, a bag leak detection system according to the requirements in... performance test on an operating day average basis. (c) Each bag leak detection system used to comply with...

17 CFR 256.237 - Interest accrued.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Interest accrued. 256.237... COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.237 Interest accrued. This account shall include the amount of interest accrued on all liabilities of the service company. Supporting records shall...

17 CFR 256.237 - Interest accrued.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Interest accrued. 256.237... COMPANY ACT OF 1935 7. Current and Accrued Liabilities § 256.237 Interest accrued. This account shall include the amount of interest accrued on all liabilities of the service company. Supporting records shall...

Design of HIFU transducers for generating specified nonlinear ultrasound fields

PubMed Central

Rosnitskiy, Pavel B.; Yuldashev, Petr V.; Sapozhnikov, Oleg A.; Maxwell, Adam; Kreider, Wayne; Bailey, Michael R.; Khokhlova, Vera A.

2016-01-01

Various clinical applications of high intensity focused ultrasound (HIFU) have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of this work was to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasilinear conditions at the focus. Multi-parametric nonlinear modeling based on the KZK equation with an equivalent source boundary condition was employed. Peak pressures, shock amplitudes at the focus, and corresponding source outputs were determined for different transducer geometries and levels of nonlinear distortion. Results are presented in terms of the parameters of an equivalent single-element, spherically shaped transducer. The accuracy of the method and its applicability to cases of strongly focused transducers were validated by comparing the KZK modeling data with measurements and nonlinear full-diffraction simulations for a single-element source and arrays with 7 and 256 elements. The results provide look-up data for evaluating nonlinear distortions at the focus of existing therapeutic systems as well as for guiding the design of new transducers that generate specified nonlinear fields. PMID:27775904

Heavy metals and mineral elements not included on the nutritional labels in table olives.

PubMed

López-López, Antonio; López, Rafael; Madrid, Fernando; Garrido-Fernández, Antonio

2008-10-22

The average contents, in mg/kg edible portion (e.p.), of elements not considered for nutritional labeling in Spanish table olives were as follows: aluminum, 71.1; boron, 4.41; barium, 2.77; cadmium, 0.04; cobalt, 0.12; chromium, 0.19; lithium, 6.56; nickel, 0.15; lead, 0.15; sulfur, 321; tin, 18.4; strontium, 9.71; and zirconium, 0.04. Sulfur was the most abundant element in table olives, followed by aluminum and tin (related to green olives). There were significant differences between elaboration styles, except for aluminum, tin, and sulfur. Ripe olives had significantly higher concentrations (mg/kg e.p.) of boron (5.32), barium (3.91), cadmium (0.065), cobalt (0.190), chromium (0.256), lithium (10.01), nickel (0.220), and strontium (10.21), but the levels of tin (25.55) and zirconium (0.039) were higher in green olives. The content of contaminants (cadmium, nickel, and tin) was always below the maximum limits legally established. The discriminant analysis led to an overall 86% correct classification of cases (80% after cross-validation).

The effect of melt composition on the partitioning of trace elements between titanite and silicate melt

NASA Astrophysics Data System (ADS)

Prowatke, S.; Klemme, S.

2003-04-01

The aim of this study is to systematically investigate the influence of melt composition on the partitioning of trace elements between titanite and different silicate melts. Titanite was chosen because of its important role as an accessory mineral, particularly with regard to intermediate to silicic alkaline and calc-alkaline magmas [e.g. 1] and of its relative constant mineral composition over a wide range of bulk compositions. Experiments at atmospheric pressure were performed at temperatures between 1150°C and 1050°C. Bulk compositions were chosen to represent a basaltic andesite (SH3 - 53% SiO2), a dacite (SH2 - 65 SiO2) and a rhyolite (SH1 - 71% SiO2). Furthermore, two additional experimental series were conducted to investigate the effect of Al-Na and the Na-K ratio of melts on partitioning. Starting materials consisted of glasses that were doped with 23 trace elements including some selected rare earth elements (La, Ce, Pr, Sm, Gd, Lu), high field strength elements (Zr, Hf, Nb, Ta) and large ion lithophile elements (Cs, Rb, Ba) and Th and U. The experimental run products were analysed for trace elements using secondary ion mass spectrometry at Heidelberg University. Preliminary results indicate a strong effect of melt composition on trace element partition coefficients. Partition coefficients for rare-earth elements uniformly show a convex-upward shape [2, 3], since titanite accommodates the middle rare-earth elements more readily than the light rare-earth elements or the heavy rare-earth elements. Partition coefficients for the rare-earth elements follow a parabolic trend when plotted against ionic radius. The shape of the parabola is very similar for all studied bulk compositions, the position of the parabola, however, is strongly dependent on bulk composition. For example, isothermal rare-earth element partition coefficients (such as La) are incompatible (D<1) in alkali-rich silicate melts and strongly compatible (D>>1) in alkali-poor melt compositions. From our experimental data we present an model that combines the influence of the crystal lattice on partitioning with the effect of melt composition on trace element partition coefficients. [1] Nakada, S. (1991) Am. Mineral. 76: 548-560 [2] Green, T.H. and Pearson, N.J. (1986) Chem. Geol. 55: 105-119 [3] Tiepolo, M.; Oberti, R. and Vannucci, R. (2002) Chem. Geol. 191: 105-119

42 CFR 447.256 - Procedures for CMS action on assurances and State plan amendments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... plan amendments. 447.256 Section 447.256 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... action on assurances and State plan amendments. (a) Criteria for approval. (1) CMS approval action on State plans and State plan amendments, is taken in accordance with subpart B of part 430 of this chapter...

42 CFR 447.256 - Procedures for CMS action on assurances and State plan amendments.

Code of Federal Regulations, 2013 CFR

2013-10-01

... plan amendments. 447.256 Section 447.256 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... action on assurances and State plan amendments. (a) Criteria for approval. (1) CMS approval action on State plans and State plan amendments, is taken in accordance with subpart B of part 430 of this chapter...

17 CFR 256.409 - Income taxes.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Income taxes. 256.409 Section... COMPANY ACT OF 1935 Income and Expense Accounts § 256.409 Income taxes. (a) This account shall include the amount of local, State and Federal taxes on income properly accruable during the period covered by the...

27 CFR 24.256 - Bottle aging wine.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle aging wine. 24.256... OF THE TREASURY LIQUORS WINE Storage, Treatment and Finishing of Wine Bottling, Packing, and Labeling of Wine § 24.256 Bottle aging wine. Wine bottled or packed and stored for the purpose of aging need...

17 CFR 256.01-5 - Determination of service cost accounting.

Code of Federal Regulations, 2010 CFR

2010-04-01

... accounting. Service at cost and fair allocation of costs require, first of all, an accurate accounting for... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Determination of service cost accounting. 256.01-5 Section 256.01-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

17 CFR 256.411.5 - Investment tax credit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Investment tax credit. 256.411... HOLDING COMPANY ACT OF 1935 Income and Expense Accounts § 256.411.5 Investment tax credit. (a) This account shall be debited with the amounts of investment tax credits related to service company property...

40 CFR 256.27 - Recommendation for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommendation for schedules leading to compliance with the prohibition of open dumping. 256.27 Section 256.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE...

40 CFR 256.27 - Recommendation for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommendation for schedules leading to compliance with the prohibition of open dumping. 256.27 Section 256.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE...

40 CFR 256.26 - Requirement for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirement for schedules leading to compliance with the prohibition of open dumping. 256.26 Section 256.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE...

40 CFR 256.26 - Requirement for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement for schedules leading to compliance with the prohibition of open dumping. 256.26 Section 256.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE...

40 CFR 256.27 - Recommendation for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommendation for schedules leading to compliance with the prohibition of open dumping. 256.27 Section 256.27 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE...

40 CFR 256.26 - Requirement for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement for schedules leading to compliance with the prohibition of open dumping. 256.26 Section 256.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Review, negotiation, and approval of bids. 422.256..., and Related Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a... aggregate bid amounts submitted under § 422.252 and conduct negotiations with MA organizations regarding...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Review, negotiation, and approval of bids. 422.256..., and Related Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a... aggregate bid amounts submitted under § 422.252 and conduct negotiations with MA organizations regarding...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Review, negotiation, and approval of bids. 422.256..., and Related Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a... aggregate bid amounts submitted under § 422.252 and conduct negotiations with MA organizations regarding...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Review, negotiation, and approval of bids. 422.256... Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a) Authority. Subject to... submitted under § 422.252 and conduct negotiations with MA organizations regarding these bids (including the...

42 CFR 422.256 - Review, negotiation, and approval of bids.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Review, negotiation, and approval of bids. 422.256... Information and Plan Approval § 422.256 Review, negotiation, and approval of bids. (a) Authority. Subject to... submitted under § 422.252 and conduct negotiations with MA organizations regarding these bids (including the...

17 CFR 256.411.5 - Investment tax credit.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Investment tax credit. 256.411... HOLDING COMPANY ACT OF 1935 Income and Expense Accounts § 256.411.5 Investment tax credit. (a) This account shall be debited with the amounts of investment tax credits related to service company property...

30 CFR 256.0 - Authority for information collection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.0 Authority for information collection. (a... information collection is “30 CFR part 256, Leasing of Sulphur or Oil and Gas in the Outer Continental Shelf...

17 CFR 256.409 - Income taxes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Income taxes. 256.409 Section... COMPANY ACT OF 1935 Income and Expense Accounts § 256.409 Income taxes. (a) This account shall include the amount of local, State and Federal taxes on income properly accruable during the period covered by the...

31 CFR 256.31 - How does FMS compute interest on payments?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false How does FMS compute interest on payments? 256.31 Section 256.31 Money and Finance: Treasury Regulations Relating to Money and Finance... compute interest on payments? FMS computes interest according to the terms of the statute that waives...

24 CFR 232.256 - Partial payment of claims.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Partial payment of claims. 232.256 Section 232.256 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

24 CFR 232.256 - Partial payment of claims.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Partial payment of claims. 232.256 Section 232.256 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN...

30 CFR 256.65 - Attorney General review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Attorney General review. 256.65 Section 256.65... give due consideration to the views of the Attorney General. The Secretary may act on an assignment or transfer if the Attorney General has not responded to the request for consultation within 30 days of said...

30 CFR 250.256 - What related facilities and operations information must accompany the DPP or DOCD?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What related facilities and operations information must accompany the DPP or DOCD? 250.256 Section 250.256 Mineral Resources MINERALS MANAGEMENT... SHELF Plans and Information Contents of Development and Production Plans (dpp) and Development...

40 CFR 256.60 - Requirements for public participation in State and substate plans.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for public participation in State and substate plans. 256.60 Section 256.60 Protection of Environment ENVIRONMENTAL PROTECTION... shall: (1) Publicize information in news media having broad audiences in the geographic area; (2) Place...

40 CFR 256.60 - Requirements for public participation in State and substate plans.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for public participation in State and substate plans. 256.60 Section 256.60 Protection of Environment ENVIRONMENTAL PROTECTION... shall: (1) Publicize information in news media having broad audiences in the geographic area; (2) Place...

40 CFR 256.60 - Requirements for public participation in State and substate plans.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for public participation in State and substate plans. 256.60 Section 256.60 Protection of Environment ENVIRONMENTAL PROTECTION... shall: (1) Publicize information in news media having broad audiences in the geographic area; (2) Place...

40 CFR 256.60 - Requirements for public participation in State and substate plans.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for public participation in State and substate plans. 256.60 Section 256.60 Protection of Environment ENVIRONMENTAL PROTECTION... shall: (1) Publicize information in news media having broad audiences in the geographic area; (2) Place...

17 CFR 256.01-4 - Construction or service contracts, and centralized procurement accounting.

Code of Federal Regulations, 2010 CFR

2010-04-01

... expenses directly attributable to construction work shall be excluded from the accounting system of the... companies. Cost of goods procured shall be excluded from the accounting system of the service company and... contracts, and centralized procurement accounting. 256.01-4 Section 256.01-4 Commodity and Securities...

30 CFR 256.43 - Chargeability for production.

Code of Federal Regulations, 2010 CFR

2010-07-01

....41 of this part, chargeability under § 256.46(g) of this part, 1.454 barrels of natural gas liquids... SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Issuance of Leases § 256.43 Chargeability for..., certificate of deposit for a security, fractional undivided interest in oil, gas, or other mineral rights, or...

30 CFR 256.80 - Leases of other minerals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Leases of other minerals. 256.80 Section 256.80 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE....80 Leases of other minerals. The existence of a lease that meets the requirements of section 6(a) of...

48 CFR 9.105-2 - Determinations and documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... a responsive small business lacks certain elements of responsibility, the contracting officer shall... business concern (see subpart 19.6), the contracting officer shall accept the Small Business Administration... integrity and business ethics; and (C) The Small Business Administration does not issue a Certificate of...

48 CFR 9.105-2 - Determinations and documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... a responsive small business lacks certain elements of responsibility, the contracting officer shall... business concern (see subpart 19.6), the contracting officer shall accept the Small Business Administration... integrity and business ethics; and (C) The Small Business Administration does not issue a Certificate of...

48 CFR 9.105-2 - Determinations and documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... a responsive small business lacks certain elements of responsibility, the contracting officer shall... business concern (see subpart 19.6), the contracting officer shall accept the Small Business Administration... integrity and business ethics; and (C) The Small Business Administration does not issue a Certificate of...

Grid Effect on Spherical Shallow Water Jets Using Continuous and Discontinuous Galerkin Methods

DTIC Science & Technology

2013-01-01

The high-order Legendre -Gauss-Lobatto (LGL) points are added to the linear grid by projecting the linear elements onto the auxiliary gnomonic space...mapping, the triangles are subdivided into smaller ones by a Lagrange polynomial of order nI . The number of quadrilateral elements and grid points of...of the acceleration of gravity and the vertical height of the fluid), ν∇2 is the artificial viscosity term of viscous coefficient ν = 1× 105 m2 s−1

The Correlation Between Subjective and Objective Measures of Coded Speech Quality and Intelligibility Following Noise Corruption

DTIC Science & Technology

1981-12-01

VALUES OF EACH BLOCK C TO BE PRINTED. C C ASTORE - 256 VALUE REAL ARRAY USED TO C STORE THE CONVERTED VOLTAGES C FROM ISTORE C C SBLK- STARTING BLOCK...BETWEEN -5.00 C VOLTS AND +5.00 VOLTS. C ~c INTEGER IFILE(13),SBLK,CBLK,ISTORE(256),ST(22), " IBLOCKSJFILE(13),EBLK t :- C REAL ASTORE (256) C C ENTER...CONVERT EACH BLOCK TO BE PRINTED INTO VOLTAGES AND C STORE IN THE ARRAY ASTORE . WRITE ASTORE INTO THE C FILE NAMED BY JFILE C C DO 60 I=1,256 ASTORE (I

A positive immunoselection method to isolate villous cytotrophoblast cells from first trimester and term placenta to high purity.

PubMed

Pötgens, A J G; Kataoka, H; Ferstl, S; Frank, H-G; Kaufmann, P

2003-04-01

We developed a method for isolating highly pure villous cytotrophoblast cells from first trimester and term placenta that excludes extravillous trophoblast and syncytiotrophoblast fragments. The method is based on positive immunoselection using an antibody (mAb C76/18) reacting with hepatocyte growth factor activator inhibitor 1, HAI-1, a membrane antigen on villous cytotrophoblast. As a comparison, we also immunopurified cells using an antibody against CD105, present on syncytiotrophoblast and some extravillous trophoblast cells. The isolates were characterized by flow cytometry. HAI-1-positive cells from first trimester and term placentae were highly pure (>98 per cent cytokeratin 7-positive) mononuclear trophoblast cells. These isolations were contaminated with only very small percentages of vimentin and CD45-positive cells. HAI-1-positive trophoblast cells lacked CD105 and also HLA class I, a marker for extravillous trophoblast. In culture HAI-1-positive cells adhered, displayed an epithelial morphology, and survived for more than three days. In contrast, CD105-positive cell fractions from first trimester placenta were a heterogeneous mixture of mononuclear and multinuclear elements consisting of syncytiotrophoblast fragments, extravillous trophoblast cells, as well as around 5 per cent non-trophoblastic contaminants. In conclusion, the positive immunoselection method using antibody C76/18 yielded highly pure villous cytotrophoblast cells devoid of elements derived from syncytiotrophoblast or extravillous trophoblast.

25 CFR 256.24 - Will I need flood insurance?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Will I need flood insurance? 256.24 Section 256.24... Will I need flood insurance? You will need flood insurance if your dwelling is located in an area identified as having special flood hazards under the Flood Disaster Protection Act of 1973 (Pub. L. 93-234...

30 CFR 256.58 - Termination of the period of liability and cancellation of a bond.

Code of Federal Regulations, 2011 CFR

2011-07-01

... provide an alternative form of security, and the Regional Director determines that the alternative form of... cancellation of a bond. 256.58 Section 256.58 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... retain other forms of security as shown in the following table: For the following type of bond The period...

30 CFR 250.256 - What related facilities and operations information must accompany the DPP or DOCD?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What related facilities and operations information must accompany the DPP or DOCD? 250.256 Section 250.256 Mineral Resources BUREAU OF OCEAN ENERGY... OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of Development and Production Plans...

31 CFR 256.41 - When is reimbursement due for CDA and No FEAR payments?

Code of Federal Regulations, 2010 CFR

2010-07-01

... No FEAR payments? 256.41 Section 256.41 Money and Finance: Treasury Regulations Relating to Money and... When is reimbursement due for CDA and No FEAR payments? Reimbursement for a CDA or No FEAR payment... Management (OPM) regulations, No FEAR reimbursements or payment reimbursement plans must be made within 45...

33 CFR 127.1205 - Emergency shutdown.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Hazardous Gas Equipment § 127.1205 Emergency shutdown. (a) Each... elements that melt at less than 105 °C (221 °F) and activate the emergency shutdown, or have a sensor that...

33 CFR 127.1205 - Emergency shutdown.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Hazardous Gas Equipment § 127.1205 Emergency shutdown. (a) Each... elements that melt at less than 105 °C (221 °F) and activate the emergency shutdown, or have a sensor that...

31 CFR 215.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE WITHHOLDING OF DISTRICT OF COLUMBIA, STATE, CITY AND....S.C. 105 and 102, respectively) and the United States Postal Service; and in addition, for city or county withholding purposes only, all elements of the judicial branch. (b) City means any unit of general...

31 CFR 215.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE WITHHOLDING OF DISTRICT OF COLUMBIA, STATE, CITY AND....S.C. 105 and 102, respectively) and the United States Postal Service; and in addition, for city or county withholding purposes only, all elements of the judicial branch. (b) City means any unit of general...

Structure-guided modification of Rhizomucor miehei lipase for production of structured lipids.

PubMed

Zhang, Jun-Hui; Jiang, Yu-Yan; Lin, Ying; Sun, Yu-Fei; Zheng, Sui-Ping; Han, Shuang-Yan

2013-01-01

To improve the performance of yeast surface-displayed Rhizomucor miehei lipase (RML) in the production of human milk fat substitute (HMFS), we mutated amino acids in the lipase substrate-binding pocket based on protein hydrophobicity, to improve esterification activity. Five mutants: Asn87Ile, Asn87Ile/Asp91Val, His108Leu/Lys109Ile, Asp256Ile/His257Leu, and His108Leu/Lys109Ile/Asp256Ile/His257Leu were obtained and their hydrolytic and esterification activities were assayed. Using Discovery Studio 3.1 to build models and calculate the binding energy between lipase and substrates, compared to wild-type, the mutant Asp256Ile/His257Leu was found to have significantly lower energy when oleic acid (3.97 KJ/mol decrease) and tripalmitin (7.55 KJ/mol decrease) were substrates. This result was in accordance with the esterification activity of Asp256Ile/His257Leu (2.37-fold of wild-type). The four mutants were also evaluated for the production of HMFS in organic solvent and in a solvent-free system. Asp256Ile/His257Leu had an oleic acid incorporation of 28.27% for catalyzing tripalmitin and oleic acid, and 53.18% for the reaction of palm oil with oleic acid. The efficiency of Asp256Ile/His257Leu was 1.82-fold and 1.65-fold that of the wild-type enzyme for the two reactions. The oleic acid incorporation of Asp256Ile/His257Leu was similar to commercial Lipozyme RM IM for palm oil acidolysis with oleic acid. Yeast surface-displayed RML mutant Asp256Ile/His257Leu is a potential, economically feasible catalyst for the production of structured lipids.

Extending the Advanced Forensic Format to Accommodate Multiple Data Sources, Logical Evidence, Arbitrary Information and Forensic Workflow

DTIC Science & Technology

2009-01-01

objects, and in particular the attribute of SHA256 hash is expressed (but other attributes may also be expressed). Digital signatures have been used in...34a62f06/00000 aff4: sha256 ¼þXf4i..7rPCgo ¼ urn:aff4:34a62f06/00000.idx aff4: sha256 ¼ ptV7xOK6..C7R6Xs ¼ urn:aff4:34a62f06/properties aff4: sha256 ¼ yoZ..YMtk...urn:aff4:34a62f06 aff4: sha256 ¼ udajC5C.BVii7psU ¼ fls-i aff4 ‘‘NY case 1’’ aff4imager -i -o http://ny.wan/evidence2.aff4 \\ -k http://ny.wan/alice.key

Serum concentrations of trace elements in patients with Crohn's disease receiving enteral nutrition.

PubMed

Johtatsu, Tomoko; Andoh, Akira; Kurihara, Mika; Iwakawa, Hiromi; Tsujikawa, Tomoyuki; Kashiwagi, Atsunori; Fujiyama, Yoshihide; Sasaki, Masaya

2007-11-01

We investigated the trace element status in Crohn's disease (CD) patients receiving enteral nutrition, and evaluated the effects of trace element-rich supplementation. Thirty-one patients with CD were enrolled in this study. All patients were placed on an enteral nutrition regimen with Elental(R) (Ajinomoto pharmaceutical. Ltd., Tokyo, Japan). Serum selenium, zinc and copper concentrations were determined by atomic absorption spectroscopy. Serum selenoprotein P levels were determined by an ELISA system. Average serum levels of albumin, selenium, zinc and copper were 4.1 +/- 0.4 g/dl, 11.2 +/- 2.8 microg/dl, 71.0 +/- 14.8 microg/dl, and 112.0 +/- 25.6 microg/dl, respectively. In 9 patients of 31 CD patients, serum albumin levels were lower than the lower limit of the normal range. Serum selenium, zinc and copper levels were lower than lower limits in 12 patients, 9 patients and 1 patient, respectively. Serum selenium levels significantly correlated with both serum selenoprotein P levels and glutathione peroxidase activity. Supplementation of selenium (100 microg/day) and zinc (10 mg/day) for 2 months significantly improved the trace element status in CD patients. In conclusion, serum selenium and zinc levels are lower in many CD patients on long-term enteral nutrition. In these patients, supplementation of selenium and zinc was effective in improving the trace element status.

Ahmed glaucoma valve in eyes with preexisting episcleral encircling element

PubMed Central

Choudhari, Nikhil Shreeram; George, Ronnie; Shantha, Balekudaru; Neog, Aditya; Tripathi, Shweta; Srinivasan, Bhaskar; Vijaya, Lingam

2014-01-01

Background: To describe the use of Ahmed glaucoma valve (AGV) in the management of intractable glaucoma in eyes with a preexisting episcleral encircling element. Materials and Methods: This is a retrospective, consecutive, noncomparative study. The study included 12 eyes of 12 patients with a preexisting episcleral encircling element that underwent implantation of silicone AGV to treat intractable glaucoma during January 2009 to September 2010. Results: The mean patient age was 25.6 (standard deviation 17.1) years. Five (41.6%) patients were monocular. The indications for AGV were varied. The mean duration between placement of episcleral encircling element and implantation of AGV was 30.5 (33.8) months. The mean follow-up was 37.4 (22.9) weeks. Preoperatively, the mean intraocular pressure (IOP) was 31.4 (7.9) mmHg and the mean antiglaucoma medications were 2.8. At the final postoperative follow-up, the mean IOP was 12.5 (3.5) mmHg and the mean number of antiglaucoma medications was 0.8 (P < 0.001). The complications observed over the follow-up period did include corneal graft failure in three eyes, tube erosion in two eyes and rhegmatogenous retinal detachment in one eye. Conclusion: AGV is an effective option in the management of intractable glaucoma in eyes with a preexisting episcleral encircling element keeping in mind the possibility of significant postoperative complications. PMID:24881603

LBNL DSD Whole Frog Project

Science.gov Websites

500 x 1Byte x 136 images. So each 500 bytes from this dataset represents one scan line of the slice image. For example, using PBM: Get frame one: rawtopgm 256 256 < tomato.data > frame1 Get frames one to four into a single image: rawtopgm 256 1024 < tomato.data >frame1-4 Get frame two (skip

The Natural Selection of the Chemical Elements (by R. J. P. Williams and J. J. R. Fraústo da Silva)

NASA Astrophysics Data System (ADS)

Kauffman, George B.

1998-12-01

Clarendon: New York, 1996. xxvi + 646 pp. Figs., tables. 20.5 x 25.6 cm. ISBN 0-19-855843-0. $80.00. R. J. P. Williams, Royal Society Research Professor Emeritus at Wadham College, Oxford University, and J. J. R. Fraústo da Silva, Professor of Analytical Chemistry at the Instituto Superior Técnico, Universidade Técnica de Lisboa, have collaborated on two previous volumes: New Trends in Bio-inorganic Chemistry (1978) and The Biological Chemistry of the Elements (3rd printing, 1994). Their latest collaborative effort is a book whose ambitious objective is "to show the relationship of every kind of material around us, living and nonliving, to the properties of the chemical elements of the periodic table." The "natural selection" of the chemical elements results from a number of factors, all of which are described in detail. Among these are chemical affinity related to the electronic configuration of their atoms, thermodynamic and kinetic stability, and "functional value to an organisation such as a living system". The physicist's approach to material through phase structure and the phase rule is stressed rather than the chemist's approach through bonding theories. The entire book possesses a strong environmental and interdisciplinary emphasis.

Air quality in urban parking garages (PM10, major and trace elements, PAHs): Instrumental measurements vs. active moss biomonitoring

NASA Astrophysics Data System (ADS)

Vuković, Gordana; Aničić Urošević, Mira; Razumenić, Ivana; Kuzmanoski, Maja; Pergal, Miodrag; Škrivanj, Sandra; Popović, Aleksandar

2014-03-01

This study was performed in four parking garages in downtown of Belgrade with the aim to provide multi-pollutant assessment. Concentrations of 16 US EPA priority PAHs and Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, Sr and Zn were determined in PM10 samples. The carcinogenic health risk of employees' occupational exposure to heavy metals (Cd, Cr, Ni and Pb) and PAHs (B[a]A, Cry, B[b]F, B[k]F, B[a]P and DB[ah]A) was estimated. A possibility of using Sphagnum girgensohnii moss bags for monitoring of trace element air pollution in semi-enclosed spaces was evaluated as well. The results showed that concentrations of PM10, Cd, Ni and B[a]P exceeded the EU Directive target values. Concentration of Zn, Ba and Cu were two orders of magnitude higher than those measured at different urban sites in European cities. Cumulative cancer risk obtained for heavy metals and PAHs was 4.51 × 10-5 and 3.75 × 10-5 in M and PP, respectively; upper limit of the acceptable US EPA range is 10-4. In the moss, higher post-exposure than pre-exposure (background) element concentrations was observed. In comparison with instrumental monitoring data, similar order of abundances of the most elements in PM10 and moss samples was found. However, using of the S. girgensohnii moss bag technique in indoor environments needs further justification.

76 FR 41323 - Over-the-Road Bus Accessibility Program Grants

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

..., authorized by Section 3038 of the Transportation Equity Act for the 21st Century (TEA-21). The OTRB... (TEA-21), Public Law 105-85 as amended by the Safe, Accountable, Flexible, Efficient, Transportation... bus services. These services are an important element of the U.S. transportation system. TEA-21...

Direct evidence for interaction between nano-anatase and superoxide dismutase from rat erythrocytes

NASA Astrophysics Data System (ADS)

Ma, Linglan; Ze, Yuguang; Liu, Jie; Liu, Huiting; Liu, Chao; Li, Zhongrui; Zhao, Jinfang; Yan, Jinying; Duan, Yanmei; Xie, Yaning; Hong, Fashui

2009-07-01

Nano-TiO2 and superoxide dismutase (SOD, EC 1.15.1.1) have been added to cosmetics and used to prevent injury of skin from UV-radiation, which might be related to the decrease of oxidative damage of skin. In previous studies we had proven that nano-anatase could increase the activity of SOD and decrease the oxidative damage in vivo. The mechanisms by which nano-anatase promoted SOD activity, however, are still not clearly understood. In the present work, nano-anatase in various concentrations was added to SOD from rat erythrocytes in vitro to gain insight into the mechanism of molecular interactions between nano-anatase and SOD by various spectral methods, suggesting that the reaction between SOD and nano-anatase was two-order, which meant that the SOD activity was greatly increased by low concentration of nano-anatase and inhibited by high concentration of nano-anatase. The spectroscopic assays suggested that the nano-anatase was determined to directly bind to SOD; the binding site of nano-anatase to SOD was 0.256 and the binding constants were 6.54 × 105 and 3.6 × 105 L mol-1; Ti was bound with three oxygen or nitrogen atoms and a sulfur atoms of amino acid residues at the Ti-O(N) and Ti-S bond lengths of 1.86 and 2.37 Å, respectively, the binding nano-anatase entirely altered the secondary structure of SOD. It implied that the nano-anatase coordination created a new metal ion-active site form in SOD, thus leading to an enhancement in SOD activity.

Design of a phased array for the generation of adaptive radiation force along a path surrounding a breast lesion for dynamic ultrasound elastography imaging.

PubMed

Ekeom, Didace; Hadj Henni, Anis; Cloutier, Guy

2013-03-01

This work demonstrates, with numerical simulations, the potential of an octagonal probe for the generation of radiation forces in a set of points following a path surrounding a breast lesion in the context of dynamic ultrasound elastography imaging. Because of the in-going wave adaptive focusing strategy, the proposed method is adapted to induce shear wave fronts to interact optimally with complex lesions. Transducer elements were based on 1-3 piezocomposite material. Three-dimensional simulations combining the finite element method and boundary element method with periodic boundary conditions in the elevation direction were used to predict acoustic wave radiation in a targeted region of interest. The coupling factor of the piezocomposite material and the radiated power of the transducer were optimized. The transducer's electrical impedance was targeted to 50 Ω. The probe was simulated by assembling the designed transducer elements to build an octagonal phased-array with 256 elements on each edge (for a total of 2048 elements). The central frequency is 4.54 MHz; simulated transducer elements are able to deliver enough power and can generate the radiation force with a relatively low level of voltage excitation. Using dynamic transmitter beamforming techniques, the radiation force along a path and resulting acoustic pattern in the breast were simulated assuming a linear isotropic medium. Magnitude and orientation of the acoustic intensity (radiation force) at any point of a generation path could be controlled for the case of an example representing a heterogeneous medium with an embedded soft mechanical inclusion.

25 CFR 256.14 - What are the steps that must be taken to process my application for the Housing Improvement Program?

Code of Federal Regulations, 2010 CFR

2010-04-01

... to process my application for the Housing Improvement Program? (a) The servicing housing office must... 25 Indians 1 2010-04-01 2010-04-01 false What are the steps that must be taken to process my application for the Housing Improvement Program? 256.14 Section 256.14 Indians BUREAU OF INDIAN AFFAIRS...

31 CFR 256.33 - For what period of time is interest computed under 31 U.S.C. 1304(b)?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false For what period of time is interest computed under 31 U.S.C. 1304(b)? 256.33 Section 256.33 Money and Finance: Treasury Regulations Relating to....33 For what period of time is interest computed under 31 U.S.C. 1304(b)? Interest is computed from...

24 CFR 221.256 - Interest rate increase and payment of mortgage insurance premiums on mortgages under § 221.60 and...

Code of Federal Regulations, 2011 CFR

2011-04-01

... of mortgage insurance premiums on mortgages under § 221.60 and § 221.65. 221.256 Section 221.256... Interest rate increase and payment of mortgage insurance premiums on mortgages under § 221.60 and § 221.65.... (c) The liability for payment of mortgage insurance premiums shall begin on and be computed from the...

Two novel compound heterozygous mutations in the BCKDHB gene that cause the intermittent form of maple syrup urine disease.

PubMed

Guo, Yi; Liming, Liu; Jiang, Li

2015-12-01

Intermittent maple syrup urine disease (MSUD) is a potentially life-threatening metabolic disorder caused by a deficiency of branched chain α-ketoacid dehydrogenase (BCKD) complex. In contrast to classic MSUD, children with the intermittent form usually have an atypical clinical manifestation. Here, we describe the presenting symptoms and clinical course of a Chinese boy with intermittent MSUD. Mutation analysis identified two previously unreported mutations in exon 7 of the BCKDHB gene: c.767A > G (p.Y256C) and c.768C > G (p.Y256X); the parents were each heterozygous for one of these mutations. In silico analysis predicted Y256C probably affects protein structure; Y256X leads to a premature stop codon. This case demonstrates intermittent MSUD should be suspected in cases with symptoms of recurrent encephalopathy, especially ataxia or marked drowsiness, which usually present after the neonatal period and in conjunction with infection. symmetrical basal ganglia damage but normal myelination in the posterior limb will assist differential diagnosis; alloisoleucine is a useful diagnostic marker and mutation analysis may be of prognostic value. These novel mutations Y256C and Y256X result in the clinical manifestation of a variant form of MSUD, expanding the mutation spectrum of this disease.

Decay properties of 256-339Ds superheavy nuclei

NASA Astrophysics Data System (ADS)

Santhosh, K. P.; Nithya, C.

2017-09-01

The decay properties of 84 isotopes of darmstadtium superheavy nuclei ( Z = 110) have been studied using various theoretical models. The proton emission half-lives, the alpha decay half-lives, the spontaneous fission half-lives and the cluster decay half-lives of all the isotopes are evaluated. The one-proton emission half-lives and the alpha decay half-lives are predicted using the Coulomb and proximity potential model for deformed nuclei (CPPMDN). The calculated alpha half-lives are compared with the available experimental results as well as with the predictions of other theoretical models. The predicted half-lives matches well with the experimental results. The one-proton half-lives are also compared with the predictions using other formalisms. The shell-effect-dependent formula of Santhosh et al. has been employed for calculating the spontaneous fission half-lives. A theoretical comparison of spontaneous fission half-lives with four different formalisms is performed. By comparing the one-proton emission half-lives, the alpha decay half-lives and the spontaneous fission half-lives decay modes are predicted for all the isotopes of Ds. It is seen that the isotopes within the range 256 ≤ A ≤ 263 and 279 ≤ A ≤ 339 decay through spontaneous fission and the isotopes 264 ≤ A ≤ 278 exhibit alpha decay. Cluster decay half-lives are calculated using different models including the Coulomb and proximity potential (CPPM), for determining the magicities in the superheavy region. The effect of magicity at N = 184 and N = 202 were confirmed from the plot of log_{10}T_{1/2} versus neutron number of the daughter nuclei for the emission of different clusters. We hope that the systematic and detailed study of all the possible decay modes of 256-339Ds using various theoretical models will be helpful in the experimental identification of the isotopes of the element in the future.

Distribution, sources, and fluxes of heavy metals in the Pearl River Delta, South China.

PubMed

Geng, Junjie; Wang, Yiping; Luo, Hanjin

2015-12-30

Riverine samples were collected at various locations in the Pearl River Delta (PRD) to determine the concentrations of heavy metals (Cr, Ni, Cu, Mn, Zn, Cd, and Pb) in time and space and to estimate the fluxes of heavy metals to the coastal waters off South China. Most of the elements exhibit clear temporal and spatial trends. Principal component analysis shows that surface erosion is the major factor affecting metal concentrations in particulates in the PRD. Natural geology is an important source of these heavy metals. The annual fluxes of Cr, Ni, Cu, Mn, Zn, Cd, and Pb in upstream and downstream were 445, 256, 241, 3293, 1279, 12, and 317 t/year and 1823, 1144, 1786, 15,634, 6183, 74, and 2017 t/year, respectively. A comparison indicated that the annual fluxes of Mn accounted for 1.3% of the global river fluxes, whereas other elements contribute <1%. Copyright © 2015 Elsevier Ltd. All rights reserved.

7 CFR 1220.256 - Separability.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Miscellaneous § 1220.256 Separability. If any...

7 CFR 1220.256 - Separability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Miscellaneous § 1220.256 Separability. If any...

Complete Circular Genome Sequence of Successful ST8/SCCmecIV Community-Associated Methicillin-Resistant Staphylococcus aureus (OC8) in Russia: One-Megabase Genomic Inversion, IS256’s Spread, and Evolution of Russia ST8-IV

PubMed Central

Wan, Tsai-Wen; Higuchi, Wataru; Hung, Wei-Chun; Reva, Ivan V.; Singur, Olga A.; Gostev, Vladimir V.; Sidorenko, Sergey V.; Peryanova, Olga V.; Salmina, Alla B.; Reva, Galina V.; Teng, Lee-Jene; Yamamoto, Tatsuo

2016-01-01

ST8/SCCmecIV community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been a common threat, with large USA300 epidemics in the United States. The global geographical structure of ST8/SCCmecIV has not yet been fully elucidated. We herein determined the complete circular genome sequence of ST8/SCCmecIVc strain OC8 from Siberian Russia. We found that 36.0% of the genome was inverted relative to USA300. Two IS256, oppositely oriented, at IS256-enriched hot spots were implicated with the one-megabase genomic inversion (MbIN) and vSaβ split. The behavior of IS256 was flexible: its insertion site (att) sequences on the genome and junction sequences of extrachromosomal circular DNA were all divergent, albeit with fixed sizes. A similar multi-IS256 system was detected, even in prevalent ST239 healthcare-associated MRSA in Russia, suggesting IS256’s strong transmission potential and advantage in evolution. Regarding epidemiology, all ST8/SCCmecIVc strains from European, Siberian, and Far Eastern Russia, examined had MbIN, and geographical expansion accompanied divergent spa types and resistance to fluoroquinolones, chloramphenicol, and often rifampicin. Russia ST8/SCCmecIVc has been associated with life-threatening infections such as pneumonia and sepsis in both community and hospital settings. Regarding virulence, the OC8 genome carried a series of toxin and immune evasion genes, a truncated giant surface protein gene, and IS256 insertion adjacent to a pan-regulatory gene. These results suggest that unique single ST8/spa1(t008)/SCCmecIVc CA-MRSA (clade, Russia ST8-IVc) emerged in Russia, and this was followed by large geographical expansion, with MbIN as an epidemiological marker, and fluoroquinolone resistance, multiple virulence factors, and possibly a multi-IS256 system as selective advantages. PMID:27741255

Complete Circular Genome Sequence of Successful ST8/SCCmecIV Community-Associated Methicillin-Resistant Staphylococcus aureus (OC8) in Russia: One-Megabase Genomic Inversion, IS256's Spread, and Evolution of Russia ST8-IV.

PubMed

Wan, Tsai-Wen; Khokhlova, Olga E; Iwao, Yasuhisa; Higuchi, Wataru; Hung, Wei-Chun; Reva, Ivan V; Singur, Olga A; Gostev, Vladimir V; Sidorenko, Sergey V; Peryanova, Olga V; Salmina, Alla B; Reva, Galina V; Teng, Lee-Jene; Yamamoto, Tatsuo

2016-01-01

ST8/SCCmecIV community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been a common threat, with large USA300 epidemics in the United States. The global geographical structure of ST8/SCCmecIV has not yet been fully elucidated. We herein determined the complete circular genome sequence of ST8/SCCmecIVc strain OC8 from Siberian Russia. We found that 36.0% of the genome was inverted relative to USA300. Two IS256, oppositely oriented, at IS256-enriched hot spots were implicated with the one-megabase genomic inversion (MbIN) and vSaβ split. The behavior of IS256 was flexible: its insertion site (att) sequences on the genome and junction sequences of extrachromosomal circular DNA were all divergent, albeit with fixed sizes. A similar multi-IS256 system was detected, even in prevalent ST239 healthcare-associated MRSA in Russia, suggesting IS256's strong transmission potential and advantage in evolution. Regarding epidemiology, all ST8/SCCmecIVc strains from European, Siberian, and Far Eastern Russia, examined had MbIN, and geographical expansion accompanied divergent spa types and resistance to fluoroquinolones, chloramphenicol, and often rifampicin. Russia ST8/SCCmecIVc has been associated with life-threatening infections such as pneumonia and sepsis in both community and hospital settings. Regarding virulence, the OC8 genome carried a series of toxin and immune evasion genes, a truncated giant surface protein gene, and IS256 insertion adjacent to a pan-regulatory gene. These results suggest that unique single ST8/spa1(t008)/SCCmecIVc CA-MRSA (clade, Russia ST8-IVc) emerged in Russia, and this was followed by large geographical expansion, with MbIN as an epidemiological marker, and fluoroquinolone resistance, multiple virulence factors, and possibly a multi-IS256 system as selective advantages.

Design of HIFU Transducers for Generating Specified Nonlinear Ultrasound Fields.

PubMed

Rosnitskiy, Pavel B; Yuldashev, Petr V; Sapozhnikov, Oleg A; Maxwell, Adam D; Kreider, Wayne; Bailey, Michael R; Khokhlova, Vera A

2017-02-01

Various clinical applications of high-intensity focused ultrasound have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of this paper is to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasi-linear conditions at the focus. Multiparametric nonlinear modeling based on the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation with an equivalent source boundary condition was employed. Peak pressures, shock amplitudes at the focus, and corresponding source outputs were determined for different transducer geometries and levels of nonlinear distortion. The results are presented in terms of the parameters of an equivalent single-element spherically shaped transducer. The accuracy of the method and its applicability to cases of strongly focused transducers were validated by comparing the KZK modeling data with measurements and nonlinear full diffraction simulations for a single-element source and arrays with 7 and 256 elements. The results provide look-up data for evaluating nonlinear distortions at the focus of existing therapeutic systems as well as for guiding the design of new transducers that generate specified nonlinear fields.

Evaluation of a MMW active through-the-wall surveillance system

NASA Astrophysics Data System (ADS)

Currie, Nicholas C.; Stiefvater, Kenneth

2002-08-01

This paper discusses the TWS data collected with a state-of- the-art 100 GHz radar imager developed for law enforcement use by Millivision, PPC. The system collects a cube of data consisting of 16 azimuth elements by 16 elevation elements by 256 range elements. The cube represents 11 degrees by 11 degrees by 25 m of coverage. The relatively narrow field-of- view (fov) was extended by physically moving the antenna in 11 degree segments and collecting data which is stitched together into larger images, e.g. a 3X3 stitched image represents 33 degrees by 33 degrees by 26 m of coverage. Unfortunately, this stitching process required up to 5 minutes to collect a single (3X3) stitched image. Thus, motion had to be simulated. The paper will discuss the phenomenology of the MMW radar return from various objects including walls, wall-corners, desks and other furniture, and persons simulating walking. Successive frames from a simulated move of a man and woman walking will be presented, and the actual movie shown at the presentation. Comments will be offered as to the practicality of active MMW imaging for TWS application.

The development and test of ultra-large-format multi-anode microchannel array detector systems

NASA Technical Reports Server (NTRS)

Timothy, J. G.

1984-01-01

The specific tasks that were accomplished with each of the key elements of the multi-anode microchannel array detector system are described. The modes of operation of position-sensitive electronic readout systems for use with high-gain microchannel plates are described and their performance characteristics compared and contrasted. Multi-anode microchannel array detector systems with formats as large as 256 x 1024 pixels are currently under evaluation. Preliminary performance data for sealed ultraviolet and visible-light detector tubes show that the detector systems have unique characteristics which make them complementary to photoconductive array detectors, such as CCDs, and superior to alternative pulse-counting detector systems employing high-gain MCPs.

Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 105 Pa

PubMed Central

Berg, Robert F.

2016-01-01

This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 105 Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH. PMID:27274567

Recent advance to 3 × 10(-5) rad near diffraction-limited beam divergence of dye laser with transverse-discharge flash-lamp pumping.

PubMed

Trusov, K K

1994-02-20

A new experimental setup of a Rhodamine 6G dye laser with a transverse-discharge flash-lamp-pumping system is presented. It differs from a previous setup [Sov. J. Quantum Electron. 16, 468-471 (1989)] in that it has a larger laser beam aperture (32 mm) and higher pumping energy (1 kJ), which made it possible to test the scalability and reach near diffraction-limited laser beam divergence of 3 × 10(-5) rad FWHM at beam energy 1.4 J. The effect of spectral dispersion in the active medium and of other optical elements on the beam divergence is also discussed.

48 CFR 53.105 - Computer generation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Data Interchange or a format that can be translated into one of those standards. (b) The standards listed in paragraph (a)(2) of this section may also be used for submission of data set forth in other..., content, or sequence of the data elements, and the form carries the Standard or Optional Form number and...

48 CFR 53.105 - Computer generation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Data Interchange or a format that can be translated into one of those standards. (b) The standards listed in paragraph (a)(2) of this section may also be used for submission of data set forth in other..., content, or sequence of the data elements, and the form carries the Standard or Optional Form number and...

48 CFR 53.105 - Computer generation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Data Interchange or a format that can be translated into one of those standards. (b) The standards listed in paragraph (a)(2) of this section may also be used for submission of data set forth in other..., content, or sequence of the data elements, and the form carries the Standard or Optional Form number and...

Design of a telemetry system based on wireless power transmission for physiological parameter monitoring

NASA Astrophysics Data System (ADS)

Jia, Zhiwei; Yan, Guozheng; Zhu, Bingquan

2015-04-01

An implanted telemetry system for experimental animals with or without anaesthesia can be used to continuously monitor physiological parameters. This system is significant not only in the study of organisms but also in the evaluation of drug efficacy, artificial organs, and auxiliary devices. The system is composed of a miniature electronic capsule, a wireless power transmission module, a data-recording device, and a processing module. An electrocardiograph, a temperature sensor, and a pressure sensor are integrated in the miniature electronic capsule, in which the signals are transmitted in vitro by wireless communication after filtering, amplification, and A/D sampling. To overcome the power shortage of batteries, a wireless power transmission module based on electromagnetic induction was designed. The transmitting coil of a rectangular-section solenoid and a 3D receiving coil are proposed according to stability and safety constraints. Experiments show that at least 150 mW of power could pick up on the load in a volume of Φ10.5 mm × 11 mm, with a transmission efficiency of 2.56%. Vivisection experiments verified the feasibility of the integrated radio-telemetry system.

Real-time chirp-coded imaging with a programmable ultrasound biomicroscope.

PubMed

Bosisio, Mattéo R; Hasquenoph, Jean-Michel; Sandrin, Laurent; Laugier, Pascal; Bridal, S Lori; Yon, Sylvain

2010-03-01

Ultrasound biomicroscopy (UBM) of mice can provide a testing ground for new imaging strategies. The UBM system presented in this paper facilitates the development of imaging and measurement methods with programmable design, arbitrary waveform coding, broad bandwidth (2-80 MHz), digital filtering, programmable processing, RF data acquisition, multithread/multicore real-time display, and rapid mechanical scanning (

A simple test of one minute heart rate variability during deep breathing for evaluation of sympatovagal imbalance in hyperthyroidism.

PubMed

Shuvy, Mony; Arbelle, Jonathan E; Grosbard, Aviva; Katz, Amos

2008-01-01

Heart rate variability is a sensitive marker of cardiac sympathetic activity. To determine whether long-term hyperthyroidism induced by thyroxine suppressive therapy affects HRV. Nineteen patients treated with suppressive doses of thyroxin for thyroid cancer and 19 age-matched controls were enrolled. Thyroid function tests and 1 minute HRV were performed on all subjects and the results were compared between the groups. The 1 minute HRV was analyzed during deep breathing and defined as the difference in beats/minute between the shortest and the longest heart rate interval measured by eletrocardiographic recording during six cycles of deep breathing. One minute HRV during deep breathing was significantly lower among thyroxine-treated patients compared to healthy controls (25.6 +/- 10.5 vs. 34.3 +/- 12.6 beats/min, P < 0.05). There were no significant differences in mean, maximal and minimal heart rate between the groups. Thyroxine therapy administered for epithelial thyroid cancer resulted in subclinical hyperthyroidism and significantly decreased HRV due to autonomic dysfunction rather than basic elevated heart rate.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jia, Zhiwei, E-mail: jiayege@hotmail.com; Yan, Guozheng; Zhu, Bingquan

An implanted telemetry system for experimental animals with or without anaesthesia can be used to continuously monitor physiological parameters. This system is significant not only in the study of organisms but also in the evaluation of drug efficacy, artificial organs, and auxiliary devices. The system is composed of a miniature electronic capsule, a wireless power transmission module, a data-recording device, and a processing module. An electrocardiograph, a temperature sensor, and a pressure sensor are integrated in the miniature electronic capsule, in which the signals are transmitted in vitro by wireless communication after filtering, amplification, and A/D sampling. To overcome themore » power shortage of batteries, a wireless power transmission module based on electromagnetic induction was designed. The transmitting coil of a rectangular-section solenoid and a 3D receiving coil are proposed according to stability and safety constraints. Experiments show that at least 150 mW of power could pick up on the load in a volume of Φ10.5 mm × 11 mm, with a transmission efficiency of 2.56%. Vivisection experiments verified the feasibility of the integrated radio-telemetry system.« less

Advancing Cost-Effective Readiness by Improving the Supply Chain Management of Sparse, Intermittently-Demanded Parts

DTIC Science & Technology

2015-03-26

DEMANDED PARTS DISSERTATION Gregory H. Gehret AFIT-ENS-DS-15-M- 256 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR FORCE INSTITUTE...protection in the United States. AFIT-ENS-DS-15-M- 256 ADVANCING COST-EFFECTIVE READINESS BY IMPROVING THE SUPPLY CHAIN MANAGEMENT OF SPARSE...RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENS-DS-15-M- 256 ADVANCING COST-EFFECTIVE READINESS BY IMPROVING THE SUPPLY CHAIN MANAGEMENT OF SPARSE

Intelligence and Electronic Warfare (IEW) Streamlining Project. Volume 3. Reference Documentation (Part 2), B

DTIC Science & Technology

1992-09-01

DoC* A 0" SAF ED P To FS E’F IRA C cons SPDOD ACES OPTPS 0(14 con 0CAC -O-0( Ell 23n Doc AG DOI on @- TS A Of0 Eg D SSO OIPIV PR0C At"C EMSC EN6ICT...except as noted in specific agreements, through 30 Sep 94. (4) Distribute, on a pro rata basis, across all CMFs, those resource changes imposed by...156A (.RD) Sig Sys Maint Tech WOTTC 1 Oct 93 256A 4C-256A Sig Sys Maint Tecn WOTTC I Oct 93 256A 4-11-C32-256A-RC Phase I Sig Sys Maint Tech SWOT -RC

Effects of lead, molybdenum, rubidium, arsenic and organochlorines on spermatogenesis in fish: monitoring at Mekong Delta area and in vitro experiment.

PubMed

Yamaguchi, Sonoko; Miura, Chiemi; Ito, Aki; Agusa, Tetsuro; Iwata, Hisato; Tanabe, Shinsuke; Tuyen, Bui Cach; Miura, Takeshi

2007-06-05

To estimate the influence of water contaminants on fish reproduction in the Mekong Delta area, we sampled cultivated male catfish (Pangasianodon hypophthalmus), investigated testicular development, and measured persistent organic pollutants (POPs) and trace element levels in muscle and liver, respectively. Various testes sizes were observed although sampling took place during a short period. Histological analysis revealed that all developmental stages of germ cells were observed in catfish with large testis, whereas only necrotic spermatogonia but no other germ cells were observed in catfish with small testis. In small testis, furthermore, vacuolization and hypertrophy of Sertoli cells were observed. Measurement of POPs in muscle and trace elements in liver demonstrated that there were negative correlations between GSI and the concentrations of Pb, Mo, Rb and As. To clarify possible direct effects of Pb, Mo, Rb and As on spermatogenesis in fish, we investigated the effects of these trace elements on spermatogenesis using in vitro testicular organ culture of Japanese eel (Anguilla japonica). Treatment with each of the trace elements alone did not affect spermatogenesis. However, treatment with 10(-7)M of Pb, 10(-5) and 10(-4)M of Mo, 10(-5)-10(-3)M of Rb or 10(-5)M of As inhibited the spermatogenesis induced by 11-ketotestosterone (11KT). Furthermore, treatment with 10(-4)M of As in combination with 11KT caused necrosis of testicular fragments. Taken together, these results are consistent with the hypothesis that Pb, Mo, Rb and As can exert inhibitory effects on spermatogenesis in catfish inhabiting the Mekong Delta area.

An integrated circuit with transmit beamforming flip-chip bonded to a 2-D CMUT array for 3-D ultrasound imaging.

PubMed

Wygant, Ira O; Jamal, Nafis S; Lee, Hyunjoo J; Nikoozadeh, Amin; Oralkan, Omer; Karaman, Mustafa; Khuri-Yakub, Butrus T

2009-10-01

State-of-the-art 3-D medical ultrasound imaging requires transmitting and receiving ultrasound using a 2-D array of ultrasound transducers with hundreds or thousands of elements. A tight combination of the transducer array with integrated circuitry eliminates bulky cables connecting the elements of the transducer array to a separate system of electronics. Furthermore, preamplifiers located close to the array can lead to improved receive sensitivity. A combined IC and transducer array can lead to a portable, high-performance, and inexpensive 3-D ultrasound imaging system. This paper presents an IC flip-chip bonded to a 16 x 16-element capacitive micromachined ultrasonic transducer (CMUT) array for 3-D ultrasound imaging. The IC includes a transmit beamformer that generates 25-V unipolar pulses with programmable focusing delays to 224 of the 256 transducer elements. One-shot circuits allow adjustment of the pulse widths for different ultrasound transducer center frequencies. For receiving reflected ultrasound signals, the IC uses the 32-elements along the array diagonals. The IC provides each receiving element with a low-noise 25-MHz-bandwidth transimpedance amplifier. Using a field-programmable gate array (FPGA) clocked at 100 MHz to operate the IC, the IC generated properly timed transmit pulses with 5-ns accuracy. With the IC flip-chip bonded to a CMUT array, we show that the IC can produce steered and focused ultrasound beams. We present 2-D and 3-D images of a wire phantom and 2-D orthogonal cross-sectional images (Bscans) of a latex heart phantom.

FELIX-2.0: New version of the finite element solver for the time dependent generator coordinate method with the Gaussian overlap approximation

NASA Astrophysics Data System (ADS)

Regnier, D.; Dubray, N.; Verrière, M.; Schunck, N.

2018-04-01

The time-dependent generator coordinate method (TDGCM) is a powerful method to study the large amplitude collective motion of quantum many-body systems such as atomic nuclei. Under the Gaussian Overlap Approximation (GOA), the TDGCM leads to a local, time-dependent Schrödinger equation in a multi-dimensional collective space. In this paper, we present the version 2.0 of the code FELIX that solves the collective Schrödinger equation in a finite element basis. This new version features: (i) the ability to solve a generalized TDGCM+GOA equation with a metric term in the collective Hamiltonian, (ii) support for new kinds of finite elements and different types of quadrature to compute the discretized Hamiltonian and overlap matrices, (iii) the possibility to leverage the spectral element scheme, (iv) an explicit Krylov approximation of the time propagator for time integration instead of the implicit Crank-Nicolson method implemented in the first version, (v) an entirely redesigned workflow. We benchmark this release on an analytic problem as well as on realistic two-dimensional calculations of the low-energy fission of 240Pu and 256Fm. Low to moderate numerical precision calculations are most efficiently performed with simplex elements with a degree 2 polynomial basis. Higher precision calculations should instead use the spectral element method with a degree 4 polynomial basis. We emphasize that in a realistic calculation of fission mass distributions of 240Pu, FELIX-2.0 is about 20 times faster than its previous release (within a numerical precision of a few percents).

Supplementation with L-glutamine prevents tumor growth and cancer-induced cachexia as well as restores cell proliferation of intestinal mucosa of Walker-256 tumor-bearing rats.

PubMed

Martins, Heber Amilcar; Sehaber, Camila Caviquioli; Hermes-Uliana, Catchia; Mariani, Fernando Augusto; Guarnier, Flavia Alessandra; Vicentini, Geraldo Emílio; Bossolani, Gleison Daion Piovezana; Jussani, Laraine Almeida; Lima, Mariana Machado; Bazotte, Roberto Barbosa; Zanoni, Jacqueline Nelisis

2016-12-01

This study aimed to evaluate the intestinal mucosa of the duodenum and jejunum of Walker-256 tumor-bearing rats supplemented with L-glutamine. Thirty-two male 50-day-old Wistar rats (Rattus norvegicus) were randomly divided into four groups: control (C), control supplemented with 2 % L-glutamine (GC), Walker-256 tumor (WT), and Walker-256 tumor supplemented with 2 % L-glutamine (TWG). Walker-256 tumor was induced by inoculation viable tumor cells in the right rear flank. After 10 days, celiotomy was performed and duodenal and jejunal tissues were removed and processed. We evaluated the cachexia index, proliferation index, villus height, crypt depth, total height of the intestinal wall, and number of goblet cells by the technique of periodic acid-Schiff (PAS). Induction of Walker-256 tumor promoted a reduction of metaphase index in the TW group animals, which was accompanied by a reduction in the villous height and crypt depths, resulting in atrophy of the intestinal wall as well as increased PAS-positive goblet cells. Supplementation with L-glutamine reduced the tumor growth and inhibited the development of the cachectic syndrome in animals of the TWG group. Furthermore, amino acid supplementation promoted beneficial effects on the intestinal mucosa in the TWG animals through restoration of the number of PAS-positive goblet cells. Therefore, supplementation with 2 % L-glutamine exhibited a promising role in the prevention of tumor growth and cancer-associated cachexia as well as restoring the intestinal mucosa in the duodenum and jejunum of Walker-256 tumor-bearing rats.

Productivity, Physicochemical Changes, and Antioxidant Activity of Shiitake Culinary-Medicinal Mushroom Lentinus edodes (Agaricomycetes) Cultivated on Lignocellulosic Residues.

PubMed

Gaitán-Hernández, Rigoberto; Zavaleta, Marco Antonio Barradas; Aquino-Bolaños, Elia Nora

2017-01-01

The effects of substrate and strain on productivity, physicochemical characteristics, and compounds with antioxidant activity were evaluated in basidiomes of the shiitake mushroom, Lentinus edodes. Strains IE-245 and IE-256 and the substrates oak wood shavings (OW), sorghum stubble (SS), and sugar cane bagasse (SC) were used. Productivity was evaluated by measuring biological efficiency (BE), production rate (PR), and yield. Total sugars, total soluble solids, pH, titratable acidity, color parameters, total phenolics, flavonoids, ascorbic acid, and antioxidant activity of the basidiomes were measured. BE, PR and yield were higher with the combination IE-256/SS, at 103.71%, 1.32%, and 34.57%, respectively. The largest amount of total sugars (17.61 mg glucose · g-1 dry weight) was found with combination IE-256/SS. Variation was observed in basidiome color; the lowest luminosity (L*) value (darkest color) was found in the IE-256 strain on the OW substrate (L* = 30.45), whereas that of the IE-245 strain on the SC substrate was the lightest in color (L* = 57.00). The largest amounts of total phenolics were recorded in the IE-256 strain on the OW (6.50 mg gallic acid equivalents [GAE] · g-1 dry weight) and the SS substrates (5.85 mg GAE · g-1 dry weight). The best antioxidant activity was obtained with IE-256-0.80, 0.65, and 0.59 μmol Trolox equivalents · g dry weight-1-on the OW, SC, and SS substrates, respectively. Based on the values of BE, PR, and yield, IE-256/SS was the most productive. Substrate and strain, and their interactions, influenced the physicochemical characteristics of the basidiomes and the amounts of compounds with antioxidant activity they contained.

Screening of in vitro antimicrobial activity of plants used in traditional Indonesian medicine.

PubMed

Romulo, Andreas; Zuhud, Ervizal A M; Rondevaldova, Johana; Kokoska, Ladislav

2018-12-01

In many regions of Indonesia, there are numerous traditional herbal preparations for treatment of infectious diseases. However, their antimicrobial potential has been poorly studied by modern laboratory methods. This study investigates in vitro antimicrobial activity of 49 ethanol extracts from 37 plant species used in Indonesian traditional medicine for treatment against Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The plants were collected from the Biopharmaca collection garden, Bogor, Indonesia. The plant material was dried, finely grounded, extracted using ethanol, concentrated, and the dried residue was dissolved in 100% DMSO. Antimicrobial activity was determined in terms of a minimum inhibitory concentration (MIC) using a broth microdilution method in 96-well microplates. The extract of Orthosiphon aristatus (Blume) Miq. (Lamiaceae) leaf produced the strongest antimicrobial effect, inhibiting the growth of C. albicans (MIC 128 μg/mL), S. aureus (MIC 256 μg/mL), E. faecalis (MIC 256 μg/mL) and P. aeruginosa (MIC 256 μg/mL). The leaf extract of Woodfordia floribunda Salisb. (Lythraceae) also exhibited significant effect against C. albicans (MIC 128 μg/mL), S. aureus (MIC 256 μg/mL) and E. faecalis (MIC 256 μg/mL). Rotheca serrata (L.) Steane & Mabb. (Lamiaceae) leaf extract inhibited the growth of S. aureus (MIC 256 µg/mL) and C. albicans (MIC 256 µg/mL). The leaf extract of O. aristatus and W. floribunda exhibited a significant anti-candidal effect. Therefore, both of these plants can serve as prospective source materials for the development of new anti-candidal agents.

Fabrication and Characterization of Single-Aperture 3.5-MHz BNT-Based Ultrasonic Transducer for Therapeutic Application.

PubMed

Taghaddos, Elaheh; Ma, T; Zhong, Hui; Zhou, Qifa; Wan, M X; Safari, Ahmad

2018-04-01

This paper discusses the fabrication and characterization of 3.5-MHz single-element transducers for therapeutic applications in which the active elements are made of hard lead-free BNT-based and hard commercial PZT (PZT-841) piezoceramics. Composition of (BiNa 0.88 K 0.08 Li 0.04 ) 0.5 (Ti 0.985 Mn 0.015 )O 3 (BNKLT88-1.5Mn) was used to develop lead-free piezoelectric ceramic. Mn-doped samples exhibited high mechanical quality factor ( ) of 970, thickness coupling coefficient ( ) of 0.48, a dielectric constant ( ) of 310 (at 1 kHz), depolarization temperature ( ) of 200 °C, and coercive field ( ) of 52.5 kV/cm. Two different unfocused single-element transducers using BNKLT88-1.5Mn and PZT-841 with the same center frequency of 3.5 MHz and similar aperture size of 10.7 and 10.5 mm were fabricated. Pulse-echo response, acoustic frequency spectrum, acoustic pressure field, and acoustic intensity field of transducers were characterized. The BNT-based transducer shows linear response up to the peak-to-peak voltage of 105 V in which the maximum rarefactional acoustic pressure of 1.1 MPa, and acoustic intensity of 43 W/cm 2 were achieved. Natural focal point of this transducer was at 60 mm from the surface of the transducer.

Thermodynamic stability of boron: the role of defects and zero point motion.

PubMed

van Setten, Michiel J; Uijttewaal, Matthé A; de Wijs, Gilles A; de Groot, Robert A

2007-03-07

Its low weight, high melting point, and large degree of hardness make elemental boron a technologically interesting material. The large number of allotropes, mostly containing over a hundred atoms in the unit cell, and their difficult characterization challenge both experimentalists and theoreticians. Even the ground state of this element is still under discussion. For over 30 years, scientists have attempted to determine the relative stability of alpha- and beta-rhombohedral boron. We use density functional calculations in the generalized gradient approximation to study a broad range of possible beta-rhombohedral structures containing interstitial atoms and partially occupied sites within a 105 atoms framework. The two most stable structures are practically degenerate in energy and semiconducting. One contains the experimental 320 atoms in the hexagonal unit cell, and the other contains 106 atoms in the triclinic unit cell. When populated with the experimental 320 electrons, the 106 atom structure exhibits a band gap of 1.4 eV and an in-gap hole trap at 0.35 eV above the valence band, consistent with known experiments. The total energy of these two structures is 23 meV/B lower than the original 105 atom framework, but it is still 1 meV/B above the alpha phase. Adding zero point energies finally makes the beta phase the ground state of elemental boron by 3 meV/B. At finite temperatures, the difference becomes even larger.

17 CFR 256.308 - Office furniture and equipment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... UTILITY HOLDING COMPANY ACT OF 1935 Service Company Property Accounts § 256.308 Office furniture and... equipment, accounting machines, electronic claculators, typewriters and other mechanical office equipment. ...

17 CFR 256.308 - Office furniture and equipment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... UTILITY HOLDING COMPANY ACT OF 1935 Service Company Property Accounts § 256.308 Office furniture and... equipment, accounting machines, electronic claculators, typewriters and other mechanical office equipment. ...

The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats.

PubMed

Brito, Nara Macedo Botelho; Carvalho, Rita de Kássia Vidigal; Matos, Lia Tavares de Moura Brasil; Lobato, Rodolfo Costa; Brito, Rosângela Baía

2009-01-01

Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.

Measurement of the first ionization potential of lawrencium, element 103.

PubMed

Sato, T K; Asai, M; Borschevsky, A; Stora, T; Sato, N; Kaneya, Y; Tsukada, K; Düllmann, Ch E; Eberhardt, K; Eliav, E; Ichikawa, S; Kaldor, U; Kratz, J V; Miyashita, S; Nagame, Y; Ooe, K; Osa, A; Renisch, D; Runke, J; Schädel, M; Thörle-Pospiech, P; Toyoshima, A; Trautmann, N

2015-04-09

The chemical properties of an element are primarily governed by the configuration of electrons in the valence shell. Relativistic effects influence the electronic structure of heavy elements in the sixth row of the periodic table, and these effects increase dramatically in the seventh row--including the actinides--even affecting ground-state configurations. Atomic s and p1/2 orbitals are stabilized by relativistic effects, whereas p3/2, d and f orbitals are destabilized, so that ground-state configurations of heavy elements may differ from those of lighter elements in the same group. The first ionization potential (IP1) is a measure of the energy required to remove one valence electron from a neutral atom, and is an atomic property that reflects the outermost electronic configuration. Precise and accurate experimental determination of IP1 gives information on the binding energy of valence electrons, and also, therefore, on the degree of relativistic stabilization. However, such measurements are hampered by the difficulty in obtaining the heaviest elements on scales of more than one atom at a time. Here we report that the experimentally obtained IP1 of the heaviest actinide, lawrencium (Lr, atomic number 103), is 4.96(+0.08)(-0.07) electronvolts. The IP1 of Lr was measured with (256)Lr (half-life 27 seconds) using an efficient surface ion-source and a radioisotope detection system coupled to a mass separator. The measured IP1 is in excellent agreement with the value of 4.963(15) electronvolts predicted here by state-of-the-art relativistic calculations. The present work provides a reliable benchmark for theoretical calculations and also opens the way for IP1 measurements of superheavy elements (that is, transactinides) on an atom-at-a-time scale.

BigView Image Viewing on Tiled Displays

NASA Technical Reports Server (NTRS)

Sandstrom, Timothy

2007-01-01

BigView allows for interactive panning and zooming of images of arbitrary size on desktop PCs running Linux. Additionally, it can work in a multi-screen environment where multiple PCs cooperate to view a single, large image. Using this software, one can explore on relatively modest machines images such as the Mars Orbiter Camera mosaic [92,160 33,280 pixels]. The images must be first converted into paged format, where the image is stored in 256 256 pages to allow rapid movement of pixels into texture memory. The format contains an image pyramid : a set of scaled versions of the original image. Each scaled image is 1/2 the size of the previous, starting with the original down to the smallest, which fits into a single 256 x 256 page.

Enhanced broadband (11-15 µm) QWIP FPAs for space applications

NASA Astrophysics Data System (ADS)

Nedelcu, Alexandru; de l'Isle, Nadia B.; Truffer, Jean-Patrick; Belhaire, Eric; Costard, Eric; Bois, Philippe; Merken, Patrick; Saint-Pé, Olivier

2017-11-01

A thirty months ESA project started in March 2008, whose purpose is to expand and assess the performance of broadband (11-15μm) quantum detectors for spectro-imaging applications: Fourier Transform Spectrometers and Dispersive Spectrometers. We present here the technical requirements, the development approach chosen as well as preliminary signal to noise ratio (SNR) calculations. Our approach is fully compatible with the final array format (1024x256, pitch 50-60μm). We expect the requested uniformity, operability and SNR levels to be achieved at the goal temperatures (60K for FTS applications and 50K for DS applications). The performance level will be demonstrated on 256x256, 50μm pitch arrays. Also, operability and uniformity issues will be addressed on large mechanical 1024x256 hybrid arrays.

Volumetric gain of the human pancreas after left partial pancreatic resection: A CT-scan based retrospective study.

PubMed

Phillip, Veit; Zahel, Tina; Danninger, Assiye; Erkan, Mert; Dobritz, Martin; Steiner, Jörg M; Kleeff, Jörg; Schmid, Roland M; Algül, Hana

2015-01-01

Regeneration of the pancreas has been well characterized in animal models. However, there are conflicting data on the regenerative capacity of the human pancreas. The aim of the present study was to assess the regenerative capacity of the human pancreas. In a retrospective study, data from patients undergoing left partial pancreatic resection at a single center were eligible for inclusion (n = 185). Volumetry was performed based on 5 mm CT-scans acquired through a 256-slice CT-scanner using a semi-automated software. Data from 24 patients (15 males/9 females) were included. Mean ± SD age was 68 ± 11 years (range, 40-85 years). Median time between surgery and the 1st postoperative CT was 9 days (range, 0-27 days; IQR, 7-13), 55 days (range, 21-141 days; IQR, 34-105) until the 2nd CT, and 191 days (range, 62-1902; IQR, 156-347) until the 3rd CT. The pancreatic volumes differed significantly between the first and the second postoperative CT scans (median volume 25.6 mL and 30.6 mL, respectively; p = 0.008) and had significantly increased further by the 3rd CT scan (median volume 37.9 mL; p = 0.001 for comparison with 1st CT scan and p = 0.003 for comparison with 2nd CT scan). The human pancreas shows a measurable and considerable potential of volumetric gain after partial resection. Multidetector-CT based semi-automated volume analysis is a feasible method for follow-up of the volume of the remaining pancreatic parenchyma after partial pancreatectomy. Effects on exocrine and endocrine pancreatic function have to be evaluated in a prospective manner. Copyright © 2015 IAP and EPC. Published by Elsevier B.V. All rights reserved.

Perioperative risk of major non-cardiac surgery in patients with severe aortic stenosis: a reappraisal in contemporary practice

PubMed Central

Tashiro, Teruko; Pislaru, Sorin V.; Blustin, Jodi M.; Nkomo, Vuyisile T.; Abel, Martin D.; Scott, Christopher G.; Pellikka, Patricia A.

2014-01-01

Aims Severe aortic stenosis (SAS) is a major risk factor for death after non-cardiac surgery, but most supporting data are from studies over a decade old. We evaluated the risk of non-cardiac surgery in patients with SAS in contemporary practice. Methods and results SAS patients (valve area ≤1 cm2, mean gradient ≥40 mmHg or peak aortic velocity ≥4 m/s) undergoing intermediate or high-risk surgery were identified from surgical and echo databases of 2000–2010. Controls were matched for age, sex, and year of surgery. Post-operative (30 days) death and major adverse cardiovascular events (MACE), including death, stroke, myocardial infarction, ventricular tachycardia/fibrillation, and new or worsening heart failure, and 1-year survival were determined. There were 256 SAS patients and 256 controls (age 76 ± 11, 54.3% men). There was no significant difference in 30-day mortality (5.9% vs. 3.1%, P = 0.13). Severe aortic stenosis patients had more MACE (18.8% vs. 10.5%, P = 0.01), mainly due to heart failure. Emergency surgery, atrial fibrillation, and serum creatinine levels of >2 mg/dL were predictors of post-operative death by multivariate analysis [area under the curve: 0.81, 95% confidence intervals: 0.71–0.91]; emergency surgery was the strongest predictor of 30-day mortality for both SAS and controls. Severe aortic stenosis was the strongest predictor of 1-year mortality. Conclusion Severe aortic stenosis is associated with increased risk of MACE. In contemporary practice, perioperative mortality of patients with SAS is lower than previously reported and the difference from controls did not reach statistical significance. Emergency surgery is the strongest predictor of post-operative death. These results have implications for perioperative risk assessment and management strategies in patients with SAS. PMID:24553722

VizieR Online Data Catalog: Low-resolution near-infrared stellar spectra from CIBER (Kim+, 2017)

NASA Astrophysics Data System (ADS)

Kim, M. G.; Lee, H. M.; Arai, T.; Bock, J.; Cooray, A.; Jeong, W.-S.; Kim, S. J.; Korngut, P.; Lanz, A.; Lee, D. H.; Lee, M. G.; Matsumoto, T.; Matsuura, S.; Nam, U. W.; Onishi, Y.; Shirahata, M.; Smidt, J.; Tsumura, K.; Yamamura, I.; Zemcov, M.

2017-06-01

We present flux-calibrated near-infrared spectra of 105 stars from 0.8{<=}λ{<=}1.8μm with spectral resolution 15{<=}λ/Δλ{<=}30 over the range. The Low-Resolution Spectrometer (LRS) is one of the four optical instruments of the Cosmic Infrared Background Experiment (CIBER) payload; the others are a narrowband spectrometer and two wide-field imagers. The LRS is a prism-dispersed spectrometer with five rectangular 5.35°*2.8' slits imaging a 5.8°*5.8° field of view. The detector has 256*256 pixels at a pixel scale of 1.36'*1.36'. CIBER has flown four times (2009 February, 2010 July, 2012 March, and 2013 June) with apogees and total exposure times of over 325km and ~240s, respectively, in the first three flights and of 550km and 335s in the final, non-recovered flight. Due to spurious signal contamination from thermal emission from the shock-heated rocket skin, we do not use the first flight data in this work. The star spectral types are determined by fitting known spectral templates to the measured LRS spectra. We use the Infrared Telescope Facility (IRTF) and Pickles 1998 (Cat. J/PASP/110/863) templates for the SED fitting. The SpeX instrument installed on the IRTF observed stars using a medium-resolution spectrograph (R=2000). The template library contains spectra for 210 cool stars (F to M type) with wavelength coverage from 0.8 to 2.5μm (Cushing 2005ApJ...623.1115C; Rayner 2009ApJS..185..289R). The Pickles library is a synthetic spectral library that combines spectral data from various observations to achieve wavelength coverage from the UV (0.115μm) to the near-infrared (2.5μm). It contains 131 spectral templates for all star types (i.e., O to M type) with a uniform sampling interval of 5Å. (6 data files).

Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.

PubMed

Yu, Liping; Boulware, David C; Beam, Craig A; Hutton, John C; Wenzlau, Janet M; Greenbaum, Carla J; Bingley, Polly J; Krischer, Jeffrey P; Sosenko, Jay M; Skyler, Jay S; Eisenbarth, George S; Mahon, Jeffrey L

2012-06-01

We assessed diabetes risk associated with zinc transporter-8 antibodies (ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 diabetes with the standard biochemical autoantibodies (BAA) to insulin (IAA), GAD65 (GAD65A), and/or insulinoma-associated protein 2 antigen (IA-2A). For this analysis, 2,256 relatives positive for at least one BAA, of whom 142 developed diabetes, were tested for ZnT8A, ICA, and HLA genotype followed by biannual oral glucose tolerance tests. ZnT8A were also tested in 911 randomly chosen antibody-negative relatives. ZnT8A were associated with the other BAA (548 of 2,256 [24.3%] BAA(+) vs. 8 of 911 [0.8%] BAA(-), P < 0.001) and BAA number (177 of 1,683 [10.5%] single-, 221 of 384 [57.6%] double-, and 150 of 189 [79.4%] triple-BAA positivity, P < 0.001). The 4-year diabetes risk was higher in single BAA(+) relatives with ZnT8A than ZnT8A(-) relatives (31 vs. 7%, P < 0.001). In multivariable analysis, age ≤ 20 years (hazard ratio 2.13, P = 0.03), IA-2A (2.15, P = 0.005), IAA (1.73, P = 0.01), ICA (2.37, P = 0.002), and ZnT8A (1.87, P = 0.03) independently predicted diabetes, whereas HLA type (high and moderate vs. low risk) and GAD65A did not (P = 0.81 and 0.86, respectively). In relatives with one standard BAA, ZnT8A identified a subset at higher diabetes risk. ZnT8A predicted diabetes independently of ICA, the standard BAA, age, and HLA type. ZnT8A should be included in type 1 diabetes prediction and prevention studies.

Relevance of cutoff on a 4th generation ELISA performance in the false positive rate during HIV diagnostic in a low HIV prevalence setting.

PubMed

Chacón, Lucía; Mateos, María Luisa; Holguín, África

2017-07-01

Despite the high specificity of fourth-generation enzyme immunoassays (4th-gen-EIA) for screening during HIV diagnosis, their positive predictive value is low in populations with low HIV prevalence. Thus, screening should be optimized to reduce false positive results. The influence of sample cutoff (S/CO) values by a 4th-gen-EIA with the false positive rate during the routine HIV diagnosis in a low HIV prevalence population was evaluated. A total of 30,201 sera were tested for HIV diagnosis using Abbott Architect ® HIV-Ag/Ab-Combo 4th-gen-EIA at a hospital in Spain during 17 months. Architect S/CO values were recorded, comparing the HIV-1 positive results following Architect interpretation (S/CO≥1) with the final HIV-1 diagnosis by confirmatory tests (line immunoassay, LIA and/or nucleic acid test, NAT). ROC curve was also performed. Among the 30,201 HIV performed tests, 256 (0.85%) were positive according to Architect interpretation (S/CO≥1) but only 229 (0.76%) were definitively HIV-1 positive after LIA and/or NAT. Thus, 27 (10.5%) of 256 samples with S/CO≥1 by Architect were false positive diagnose. The false positive rate decreased when the S/CO ratio increased. All 19 samples with S/CO ≤10 were false positives and all 220 with S/CO>50 true HIV-positives. The optimal S/CO cutoff value provided by ROC curves was 32.7. No false negative results were found. We show that very low S/CO values during HIV-1 screening using Architect can result HIV negative after confirmation by LIA and NAT. The false positive rate is reduced when S/CO increases. Copyright © 2017 Elsevier B.V. All rights reserved.

40 CFR 256.05 - Annual work program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 256.05 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose, General Requirements... implementation of the State plan. ...

40 CFR 256.05 - Annual work program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 256.05 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose, General Requirements... implementation of the State plan. ...

Impact of the addition of chicken litter on mercury speciation and emissions from coal combustion in a laboratory-scale fluidized bed combustor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Songgeng Li; Shuang Deng; Andy Wu

Co-combustion of chicken litter with coal was performed in a laboratory-scale fluidized bed combustor to investigate the effect of chicken litter addition on the partitioning behavior of mercury. Gaseous total and elemental mercury concentrations in the flue gas were measured online, and ash was analyzed for particle-bound mercury along with other elemental and surface properties. The mercury mass balance was between 85 and 105%. The experimental results show that co-combustion of chicken litter decreases the amount of elemental and total mercury in the gas phase. Mercury content in fly ash increases with an increasing chicken litter share. 22 refs., 6more » figs., 5 tabs.« less

41 CFR 105-62.202 - Review of classified materials for declassification purposes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... particularity or narrow the scope of the request, the element that received the request shall notify the... referral, it shall process the request in accordance with the requirements of this paragraph and, if so...) Based upon the outcome of the appeal, a reply shall be made to the person making the appeal that either...

An Automated Acquisition System for Media Exploitation

DTIC Science & Technology

2008-06-01

on the acquisition station, AcqMan will pull out the SHA256 image hash, and the device’s model, serial number, and manufacturer. 2. Query the ADOMEX...Repository Using the data collected above, AcqMan will query the ADOMEX repository. The ADOMEX repository will respond to the query with the SHA256 ’s of...whose SHA256s do not match. The last category will be a list of images that the ADOMEX repository already has and that the acquisition station can

The Utility of fMRI for Assessing and Predicting Individual Differences in Fatigue Vulnerability

DTIC Science & Technology

2010-06-15

field of view (FOV) = 25.6 cm, image matrix = 256 x 256. Next, a set of T1-weighted axial low -resolution anatomical images encompassing the whole...wide range of central nervous system disorders and medication effects ( Lowe & Rabbitt, 1998; Randall, Fleck, Shneerson & File, 2004). These tests are...fusiform gyrus (Figure 5E); 6) Brodmann area 19 (Figure 5F); and 7) the entire cerebellum (Figure 5G ). Figure 5. Axial (top row) and sagittal

42 CFR 441.256 - Additional condition for Federal financial participation (FFP).

Code of Federal Regulations, 2010 CFR

2010-10-01

... LIMITS APPLICABLE TO SPECIFIC SERVICES Sterilizations § 441.256 Additional condition for Federal financial participation (FFP). (a) FFP is not available in expenditures for any sterilization or...

A Population-based Study Evaluating the Association between Surgery in Early Life and Child Development at Primary School Entry.

PubMed

O'Leary, James D; Janus, Magdalena; Duku, Eric; Wijeysundera, Duminda N; To, Teresa; Li, Ping; Maynes, Jason T; Crawford, Mark W

2016-08-01

It is unclear whether exposure to surgery in early life has long-term adverse effects on child development. The authors aimed to investigate whether surgery in early childhood is associated with adverse effects on child development measured at primary school entry. The authors conducted a population-based cohort study in Ontario, Canada, by linking provincial health administrative databases to children's developmental outcomes measured by the Early Development Instrument (EDI). From a cohort of 188,557 children, 28,366 children who underwent surgery before EDI completion (age 5 to 6 yr) were matched to 55,910 unexposed children. The primary outcome was early developmental vulnerability, defined as any domain of the EDI in the lowest tenth percentile of the population. Subgroup analyses were performed based on age at first surgery (less than 2 and greater than or equal to 2 yr) and frequency of surgery. Early developmental vulnerability was increased in the exposed group (7,259/28,366; 25.6%) compared with the unexposed group (13,957/55,910; 25.0%), adjusted odds ratio, 1.05; 95% CI, 1.01 to 1.08. Children aged greater than or equal to 2 yr at the time of first surgery had increased odds of early developmental vulnerability compared with unexposed children (odds ratio, 1.05; 95% CI, 1.01 to 1.10), but children aged less than 2 yr at the time of first exposure were not at increased risk (odds ratio, 1.04; 95% CI, 0.98 to 1.10). There was no increase in odds of early developmental vulnerability with increasing frequency of exposure. Children who undergo surgery before primary school age are at increased risk of early developmental vulnerability, but the magnitude of the difference between exposed and unexposed children is small.

The Occurrence of Fetal Microchimeric Cells in Endometrial Tissues Is a Very Common Phenomenon in Benign Uterine Disorders, and the Lower Prevalence of Fetal Microchimerism Is Associated with Better Uterine Cancer Prognoses

PubMed Central

Kotlabova, Katerina; Pirkova, Petra; Libalova, Pavla; Vernerova, Zdenka; Svoboda, Bohuslav; Kucera, Eduard

2014-01-01

This is the first study carried out to describe the role of fetal microchimerism (FM) in the pathogenesis of uterine cancer. The prevalence and concentration of male fetal microchimeric cells (FMCs) were examined in endometrial tissues in relation to subtypes of uterine cancer, and the histological grade and stage of the tumor. FM occurrence was analyzed in relation to risk factors, including hypertension, obesity, type 2 diabetes, dyslipidemia, age at cancer diagnosis, and patient pregnancy history. The prevalence and concentration of FMCs were examined in endometrial tissues using real-time polymerase chain reaction, SRY and β-globin sequences as markers for male fetal FMCs and total DNA. The studied group involved 47 type 1 endometrial cancers, 28 type 2 endometrial cancers, and 41 benign uterine diseases. While the prevalence of FM was decreased only in type 1 endometrial cancer, compared with benign uterine disorders (38.3% vs.70.7%; odds ratio [OR]=0.257, 95% confidence interval [CI]: 0.105 to 0.628, p=0.003), FMC concentrations did not differ within examined groups. The lower FM prevalence was detected in low-grade (grade 1 and grade 2) endometrioid cancer (38.3% vs. 70.7%, OR=0.256, 95% CI: 0.105 to 0.627, p=0.003) and in FIGO 1 tumors (40.7% vs. 70.7%, OR=0.285, 95% CI: 0.120 to 0.675, p=0.004). No correlation between FM prevalence or FMC concentrations and risk factors was demonstrated. A lower prevalence of male FM seemed to be associated with better prognoses in uterine cancer based on tumor subtype, histological grade, and stage of the tumor. PMID:24283364

A Summary Report on the NPH Evaluation of 105-L Disassembly Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshi, J.R.

2002-04-30

The L Area Disassembly Basin (LDB) is evaluated for the natural phenomena hazards (NPH) effects due to earthquake, wind, and tornado in accordance with DOE Order 420.1 and DOE-STD-1020. The deterministic analysis is performed for a Performance Category 3 (PC3) level of loads. Savannah River Site (SRS) specific NPH loads and design criteria are obtained from Engineering Standard 01060. It is demonstrated that the demand to capacity (D/C) ratios for primary and significant structural elements are acceptable (equal to or less than 1.0). Thus, 105-L Disassembly Basin building structure is qualified for the PC3 NPH effects in accordance with DOEmore » Order 420.1.« less

30 CFR 256.12 - Supplemental sales.

Code of Federal Regulations, 2011 CFR

2011-07-01

... INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.12 Supplemental sales. (a) The Secretary may conduct a...

30 CFR 256.10 - Information to States.

Code of Federal Regulations, 2011 CFR

2011-07-01

... INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.10 Information to States. (a) The information covered...

17 CFR 256.01-13 - Submission of questions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... UTILITY HOLDING COMPANY ACT OF 1935 General Instructions § 256.01-13 Submission of questions. To promote... consideration and decision. Balance Sheet Accounts: Assets and Other Debit Accounts 1. service company property ...

Increase in IS256 transposition in invasive vancomycin heteroresistant Staphylococcus aureus isolate belonging to ST100 and its derived VISA mutants.

PubMed

Di Gregorio, Sabrina; Fernandez, Silvina; Perazzi, Beatriz; Bello, Natalia; Famiglietti, Angela; Mollerach, Marta

2016-09-01

In Staphylococcus aureus, transposition of IS256 has been described to play an important role in biofilm formation and antibiotic resistance. This study describes the molecular characterization of two clinical heterogeneous vancomycin-intermediate S. aureus (hVISA) isolates recovered from the same patient (before and after antibiotic treatment) and two VISA derivatives obtained by serial passages in the presence of vancomycin. Our results showed that antibiotic treatment (in vivo and in vitro) could enhance IS256 transposition, being responsible for the eventual loss of agr function. As far as we know this is the first study that reports the increase of IS256 transposition in isogenic strains after antibiotic treatment in a clinical setting. Copyright © 2016 Elsevier B.V. All rights reserved.

An Investigation of the Feasibility of Implementing Substantial Finite Element Codes on Popular Microcomputers.

DTIC Science & Technology

1982-10-01

u~ - ii 256, Ca a- N N :3 z La11) LDw E 00 -- w ’.44 wL ) w w -- CL a - I.- (0.a) J.-O0 1-0 33 ~0 0-4 30 3 C14 04. V)V) zwI w r cd~~ - E L I-c;44x...J . 2 .La I I I I I I I I I w I LM- z 0 = W LL W z z 0r W 1-4 Eflu inz 0- 0 c r zz w a 0 "WWL 4-"I’ )V ’ 1-m a LM a 0 -j (Z r 0o oz z . 281 w N4 0n N

Early Archean Spherule Beds: Chromium Isotopes Confirm Origin through Multiple Impacts of Projectiles of Carbonaceous Chondrite Type: Comment and Reply

NASA Technical Reports Server (NTRS)

Kyte, Frank T.

2003-01-01

This is a exchange in the form of a comment and a reply in regards to an earlier article. The authors of the original article, consider it likely that virtually all of the projectile will condense with the silicate fraction, resulting in very little platinum group element fractionation in the final ejecta deposit. Further, we find no evidence in the commentator's, (i.e., Glikson), comment to support vapor fractionation. We note that the Pd/Ir ratios of published data on 2.56 Ga Hamersley Basin spherules are all greater than in chondrites, contrary to the assertion by Glikson. This is consistent with relatively high Pd concentrations (and Pd/Ir ratios) in crustal rocks.

A factor influence study of trace element bioaccumulation in moss bags.

PubMed

Cesa, M; Campisi, B; Bizzotto, A; Ferraro, C; Fumagalli, F; Nimis, P L

2008-10-01

Moss bags of Rhynchostegium riparioides were exposed to different water concentrations of 11 trace elements under laboratory conditions, according to a saturated fractional factorial design (67 treated combinations), with the aim of measuring (1) element uptake and (2) the main effects and first-order interactions of influent factors. Bioaccumulation was directly proportional to water concentration, but the uptake ratio (ranging from 10(2) to 10(5)) also depended on the concentration of other metals. The highest uptake ratios were observed for Al, Cu, Cr, Hg, and Pb. The multiple regression model showed that interactions among elements exist and induce both antagonism (Fe is the most frequent competitor) and synergism (Cr exerts a great influence on Pb and Zn uptake). Interactions might be relatively strong (as for As, Cr, and Pb) or weak (Cd and Hg). This evidence should be taken into consideration in biomonitoring surveys of industrial sites, where effluents release more than one contaminant.

Determination of sixteen elements and arsenic species in brown, polished and milled rice.

PubMed

Narukawa, Tomohiro; Matsumoto, Eri; Nishimura, Tsutomu; Hioki, Akiharu

2014-01-01

The concentrations of 16 elements in 10 rice flour samples and the distribution of the elements in the rice grains from which the flour were made were determined by ICP-MS and ICP-OES after microwave-assisted digestion of the samples. Arsenic speciation analysis was carried out by HPLC-ICP-MS following heat-assisted extraction of the sample. The concentrations of inorganic As (As(III) and As(V)), monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA) and their distribution in the rice grains were determined. Portions of the brown rice were polished/milled to different degrees to yield milled off samples and polished rice samples. All samples were powdered and analyzed for 16 elements and for As species. The recoveries and mass balances for all elements in all samples showed good agreements with the starting materials. As(III), As(V), MMAA and DMAA were detected, and the sums of the concentrations of all species in the extract were 86-105% of the total As concentration in each case.

30 CFR 256.0 - Authority for information collection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and... part 256, Leasing of Sulphur or Oil and Gas in the Outer Continental Shelf.” (b) MMS collects this...

30 CFR 256.8 - Leasing maps and diagrams.

Code of Federal Regulations, 2011 CFR

2011-07-01

... INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.8 Leasing maps and diagrams. (a) Any area of the OCS...

40 CFR 97.256 - Account error.

Code of Federal Regulations, 2010 CFR

2010-07-01

... BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS CAIR SO2 Allowance Tracking System § 97.256... any error in any CAIR SO2 Allowance Tracking System account. Within 10 business days of making such...

40 CFR 256.27 - Recommendation for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste Disposal Programs § 256.27 Recommendation for schedules leading...

40 CFR 256.26 - Requirement for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste Disposal Programs § 256.26 Requirement for schedules leading to...

40 CFR 256.26 - Requirement for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste Disposal Programs § 256.26 Requirement for schedules leading to...

40 CFR 256.27 - Recommendation for schedules leading to compliance with the prohibition of open dumping.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste Disposal Programs § 256.27 Recommendation for schedules leading...

Performance of Trellis Coded 256 QAM super-multicarrier modem VLSI's for SDH interface outage-free digital microwave radio

NASA Astrophysics Data System (ADS)

Aikawa, Satoru; Nakamura, Yasuhisa; Takanashi, Hitoshi

1994-02-01

This paper describes the performance of an outage free SXH (Synchronous Digital Hierarchy) interface 256 QAM modem. An outage free DMR (Digital Microwave Radio) is achieved by a high coding gain trellis coded SPORT QAM and Super Multicarrier modem. A new frame format and its associated circuits connect the outage free modem to the SDH interface. The newly designed VLSI's are key devices for developing the modem. As an overall modem performance, BER (bit error rate) characteristics and equipment signatures are presented. A coding gain of 4.7 dB (at a BER of 10(exp -4)) is obtained using SPORT 256 QAM and Viterbi decoding. This coding gain is realized by trellis coding as well as by increasing of transmission rate. Roll-off factor is decreased to maintain the same frequency occupation and modulation level as ordinary SDH 256 QAM modern.

Attosecond nanotechnology: NEMS of energy storage and nanostructural transformations in materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beznosyuk, Sergey A., E-mail: bsa1953@mail.ru; Maslova, Olga A., E-mail: maslova-o.a@mail.ru; Zhukovsky, Mark S., E-mail: zhukovsky@list.ru

2015-10-27

The attosecond technology of the nanoelectromechanical system (NEMS) energy storage as active center fast transformation of nanostructures in materials is considered. The self-organizing relaxation of the NEMS active center containing nanocube of 256-atoms limited by planes (100) in the FCC lattice matrix of 4d-transition metals (Ru, Rh, Pd) is described by the quantum NEMS-kinetics (NK) method. Typical for these metals change of the NEMS active center physicochemical characteristics during the time of relaxation is presented. There are three types of intermediate quasistationary states of the NEMS active center. Their forms are plainly distinguishable. The full relaxed NEMS active centers (Ru{submore » 256}, Rh{sub 256}, Pd{sub 256}) accumulate next storage energies: E{sub Ru} = 2.27 eV/at, E{sub Rh} = 1.67 eV/at, E{sub Pd} = 3.02 eV/at.« less

FELIX-2.0: New version of the finite element solver for the time dependent generator coordinate method with the Gaussian overlap approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Regnier, D.; Dubray, N.; Verriere, M.

The time-dependent generator coordinate method (TDGCM) is a powerful method to study the large amplitude collective motion of quantum many-body systems such as atomic nuclei. Under the Gaussian Overlap Approximation (GOA), the TDGCM leads to a local, time-dependent Schrödinger equation in a multi-dimensional collective space. In this study, we present the version 2.0 of the code FELIX that solves the collective Schrödinger equation in a finite element basis. This new version features: (i) the ability to solve a generalized TDGCM+GOA equation with a metric term in the collective Hamiltonian, (ii) support for new kinds of finite elements and different typesmore » of quadrature to compute the discretized Hamiltonian and overlap matrices, (iii) the possibility to leverage the spectral element scheme, (iv) an explicit Krylov approximation of the time propagator for time integration instead of the implicit Crank–Nicolson method implemented in the first version, (v) an entirely redesigned workflow. We benchmark this release on an analytic problem as well as on realistic two-dimensional calculations of the low-energy fission of 240Pu and 256Fm. Low to moderate numerical precision calculations are most efficiently performed with simplex elements with a degree 2 polynomial basis. Higher precision calculations should instead use the spectral element method with a degree 4 polynomial basis. Finally, we emphasize that in a realistic calculation of fission mass distributions of 240Pu, FELIX-2.0 is about 20 times faster than its previous release (within a numerical precision of a few percents).« less

FELIX-2.0: New version of the finite element solver for the time dependent generator coordinate method with the Gaussian overlap approximation

DOE PAGES

Regnier, D.; Dubray, N.; Verriere, M.; ...

2017-12-20

The time-dependent generator coordinate method (TDGCM) is a powerful method to study the large amplitude collective motion of quantum many-body systems such as atomic nuclei. Under the Gaussian Overlap Approximation (GOA), the TDGCM leads to a local, time-dependent Schrödinger equation in a multi-dimensional collective space. In this study, we present the version 2.0 of the code FELIX that solves the collective Schrödinger equation in a finite element basis. This new version features: (i) the ability to solve a generalized TDGCM+GOA equation with a metric term in the collective Hamiltonian, (ii) support for new kinds of finite elements and different typesmore » of quadrature to compute the discretized Hamiltonian and overlap matrices, (iii) the possibility to leverage the spectral element scheme, (iv) an explicit Krylov approximation of the time propagator for time integration instead of the implicit Crank–Nicolson method implemented in the first version, (v) an entirely redesigned workflow. We benchmark this release on an analytic problem as well as on realistic two-dimensional calculations of the low-energy fission of 240Pu and 256Fm. Low to moderate numerical precision calculations are most efficiently performed with simplex elements with a degree 2 polynomial basis. Higher precision calculations should instead use the spectral element method with a degree 4 polynomial basis. Finally, we emphasize that in a realistic calculation of fission mass distributions of 240Pu, FELIX-2.0 is about 20 times faster than its previous release (within a numerical precision of a few percents).« less

The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaynes, J.B.; Johnson, J.E.; Buskin, J.N.

1988-01-01

Muscle creatine kinase (MCK) is induced to high levels during skeletal muscle differentiation. The authors examined the upstream regulatory elements of the mouse MCK gene which specify its activation during myogenesis in culture. Fusion genes containing up to 3,300 nucleotides (nt) of MCK 5' flanking DNA in various positions and orientations relative to the bacterial chloramphenicol acetyltransferase (CAT) structural gene were transfected into cultured cells. Transient expression of CAT was compared between proliferating and differentiated MM14 mouse myoblasts and with nonmyogenic mouse L cells. The major effector of high-level expression was found to have the properties of a transcriptional enhancer.more » This element, located between 1,050 and 1,256 nt upstream of the transcription start site, was also found to have a major influence on the tissue and differentiation specificity of MCK expression; it activated either the MCK promoter or heterologous promoters only in differentiated muscle cells. Comparisons of viral and cellular enhancer sequences with the MCK enhancer revealed some similarities to essential regions of the simian virus 40 enhancer as well as to a region of the immunoglobulin heavy-chain enhancer, which has been implicated in tissue-specific protein binding. Even in the absence of the enhancer, low-level expression from a 776-nt MCK promoter retained differentiation specificity. In addition to positive regulatory elements, our data provide some evidence for negative regulatory elements with activity in myoblasts. These may contribute to the cell type and differentiation specificity of MCK expression.« less

Trace elements levels in centenarian 'dodgers'.

PubMed

Alis, Rafael; Santos-Lozano, Alejandro; Sanchis-Gomar, Fabian; Pareja-Galeano, Helios; Fiuza-Luces, Carmen; Garatachea, Nuria; Lucia, Alejandro; Emanuele, Enzo

2016-05-01

Trace element bioavailability can play a role in several metabolic and physiological pathways known to be altered during the aging process. We aimed to explore the association of trace elements with increased lifespan by analyzing the circulating levels of seven trace elements (Cr, Cu, Fe, Mn, Mo, Se and Zn) in a cohort of healthy centenarians or 'dodgers' (≥100 years, free of major age-related diseases) in comparison with sex-matched younger elderly controls. Centenarians showed significant lower Cu (783.7 (76.7, 1608.9) vs 962.5 (676.3, 2064.4)μg/mL, P<0.001), but higher Fe (1.3 (0.4, 4.7) vs 1.1 (0.5, 8.4)μg/mL, P=0.003) and Se (85.7 (43.0, 256.7) vs 77.8 (24.3, 143.8)ng/mL, P=0.002) values compared with elderly controls. The logistic regression analysis identified the combination of Cu and Se as significant predictor variables associated with successful aging (P=0.001), while receiver operating characteristic (ROC) analysis confirmed that Cu and Se (either alone or in combination) were independent variables associated with healthy aging. An 'improved' trace element profile (reduced Cu and elevated Se, which are involved in key physiological processes) could play a role in the resistance to disease showed by centenarian 'dodgers', and, therefore, at least partly, be involved in the healthy aging phenotype shown by these subjects. These results should be confirmed in larger cohorts of other geographic/ethnic origin and the potential cause-effect association tested in mechanistic experimental settings. Copyright © 2016 Elsevier GmbH. All rights reserved.

Determination of trace elements in automotive fuels by filter furnace atomic absorption spectrometry

NASA Astrophysics Data System (ADS)

Anselmi, Anna; Tittarelli, Paolo; Katskov, Dmitri A.

2002-03-01

The determination of Cd, Cr, Cu, Pb and Ni was performed in gasoline and diesel fuel samples by electrothermal atomic absorption spectrometry using the Transverse Heated Filter Atomizer (THFA). Thermal conditions were experimentally defined for the investigated elements. The elements were analyzed without addition of chemical modifiers, using organometallic standards for the calibration. Forty-microliter samples were injected into the THFA. Gasoline samples were analyzed directly, while diesel fuel samples were diluted 1:4 with n-heptane. The following characteristic masses were obtained: 0.8 pg Cd, 6.4 pg Cr, 12 pg Cu, 17 pg Pb and 27 pg Ni. The limits of determination for gasoline samples were 0.13 μg/kg Cd, 0.4 μg/kg Cr, 0.9 μg/kg Cu, 1.5 μg/kg Pb and 2.5 μg/kg Ni. The corresponding limit of determination for diesel fuel samples was approximately four times higher for all elements. The element recovery was performed using the addition of organometallic compounds to gasoline and diesel fuel samples and was between 85 and 105% for all elements investigated.

27 CFR 25.6 - Delegations of the Administrator.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., DEPARTMENT OF THE TREASURY ALCOHOL BEER Scope of Regulations § 25.6 Delegations of the Administrator. The... 27 CFR Part 25, Beer. You may obtain a copy of this order by accessing the TTB Web site (http://www...

27 CFR 25.6 - Delegations of the Administrator.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., DEPARTMENT OF THE TREASURY LIQUORS BEER Scope of Regulations § 25.6 Delegations of the Administrator. The... 27 CFR Part 25, Beer. You may obtain a copy of this order by accessing the TTB Web site (http://www...

27 CFR 25.6 - Delegations of the Administrator.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., DEPARTMENT OF THE TREASURY ALCOHOL BEER Scope of Regulations § 25.6 Delegations of the Administrator. The... 27 CFR Part 25, Beer. You may obtain a copy of this order by accessing the TTB Web site (http://www...

27 CFR 25.6 - Delegations of the Administrator.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF THE TREASURY LIQUORS BEER Scope of Regulations § 25.6 Delegations of the Administrator. The... 27 CFR Part 25, Beer. You may obtain a copy of this order by accessing the TTB Web site (http://www...

47 CFR 25.256 - Special Requirements for operations in the 3.65-3.7 GHz band.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.256 Special Requirements for....65-3.7 GHz band must negotiate in good faith with that terrestrial licensee to arrive at mutually...

47 CFR 25.256 - Special Requirements for operations in the 3.65-3.7 GHz band.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.256 Special Requirements for....65-3.7 GHz band must negotiate in good faith with that terrestrial licensee to arrive at mutually...

27 CFR 25.6 - Delegations of the Administrator.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF THE TREASURY LIQUORS BEER Scope of Regulations § 25.6 Delegations of the Administrator. The... 27 CFR Part 25, Beer. You may obtain a copy of this order by accessing the TTB Web site (http://www...

15 CFR 256.3 - Procedure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... PROGRAM § 256.3 Procedure. Arrangements for collaborative research by NIST with a Research Associate generally begin through discussions or correspondence between NIST scientists and representatives of... are followed by the consummation of a Memorandum of Agreement which is signed by NIST, the sponsoring...

15 CFR 256.3 - Procedure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... PROGRAM § 256.3 Procedure. Arrangements for collaborative research by NIST with a Research Associate generally begin through discussions or correspondence between NIST scientists and representatives of... are followed by the consummation of a Memorandum of Agreement which is signed by NIST, the sponsoring...

15 CFR 256.3 - Procedure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... PROGRAM § 256.3 Procedure. Arrangements for collaborative research by NIST with a Research Associate generally begin through discussions or correspondence between NIST scientists and representatives of... are followed by the consummation of a Memorandum of Agreement which is signed by NIST, the sponsoring...

15 CFR 256.3 - Procedure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PROGRAM § 256.3 Procedure. Arrangements for collaborative research by NIST with a Research Associate generally begin through discussions or correspondence between NIST scientists and representatives of... are followed by the consummation of a Memorandum of Agreement which is signed by NIST, the sponsoring...

15 CFR 256.3 - Procedure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... PROGRAM § 256.3 Procedure. Arrangements for collaborative research by NIST with a Research Associate generally begin through discussions or correspondence between NIST scientists and representatives of... are followed by the consummation of a Memorandum of Agreement which is signed by NIST, the sponsoring...

Creating an Assured Joint DOD and Interagency Interoperable Net-Centric Enterprise. Report of the Defense Science Board Task Force on Achieving Interoperability in a Net-Centric Environment

DTIC Science & Technology

2009-03-01

policy, elliptic curve public key cryptography using the 256 -bit prime modulus elliptic curve as specified in FIPS-186-2 and SHA - 256 are appropriate for...publications/fips/fips186-2/fips186-2-change1.pdf 76 I P ART I . CH A PT E R 5 Hashing via the Secure Hash Algorithm (using SHA - 256 and...lithography and processing techniques. Field programmable gate arrays ( FPGAs ) are a chip design of interest. These devices are extensively used in

Implementation of cryptographic hash function SHA256 in C++

NASA Astrophysics Data System (ADS)

Shrivastava, Akash

2012-02-01

This abstract explains the implementation of SHA Secure hash algorithm 256 using C++. The SHA-2 is a strong hashing algorithm used in almost all kinds of security applications. The algorithm consists of 2 phases: Preprocessing and hash computation. Preprocessing involves padding a message, parsing the padded message into m-bits blocks, and setting initialization values to be used in the hash computation. It generates a message schedule from padded message and uses that schedule, along with functions, constants, and word operations to iteratively generate a series of hash values. The final hash value generated by the computation is used to determine the message digest. SHA-2 includes a significant number of changes from its predecessor, SHA-1. SHA-2 consists of a set of four hash functions with digests that are 224, 256, 384 or 512 bits. The algorithm outputs a 256 bits message block with an internal state block of 256 bits and initial block size of 512 bits. Maximum message length in bit is generated is 2^64 -1, over all computed over a series of 64 rounds consisting or several operations such as and, or, Xor, Shr, Rot. The code will provide clear understanding of the hash algorithm and generates hash values to retrieve message digest.

Design of HIFU transducers to generate specific nonlinear ultrasound fields.

PubMed

Khokhlova, Vera A; Yuldashev, Petr V; Rosnitskiy, Pavel B; Maxwell, Adam D; Kreider, Wayne; Bailey, Michael R; Sapozhnikov, Oleg A

2016-01-01

Various clinical applications of high intensity focused ultrasound (HIFU) have different requirements on the pressure level and degree of nonlinear waveform distortion at the focus. Applications that utilize nonlinear waves with developed shocks are of growing interest, for example, for mechanical disintegration as well as for accelerated thermal ablation of tissue. In this work, an inverse problem of determining transducer parameters to enable formation of shocks with desired amplitude at the focus is solved. The solution was obtained by performing multiple direct simulations of the parabolic Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation for various parameters of the source. It is shown that results obtained within the parabolic approximation can be used to describe the focal region of single element spherical sources as well as complex transducer arrays. It is also demonstrated that the focal pressure level at which fully developed shocks are formed mainly depends on the focusing angle of the source and only slightly depends on its aperture and operating frequency. Using the simulation results, a 256-element HIFU array operating at 1.5 MHz frequency was designed for a specific application of boiling-histotripsy that relies on the presence of 90-100 MPa shocks at the focus. The size of the array elements and focusing angle of the array were chosen to satisfy technical limitations on the intensity at the array elements and desired shock amplitudes in the focal waveform. Focus steering capabilities of the array were analysed using an open-source T-Array software developed at Moscow State University.

Design of HIFU Transducers to Generate Specific Nonlinear Ultrasound Fields

NASA Astrophysics Data System (ADS)

Khokhlova, Vera A.; Yuldashev, Petr V.; Rosnitskiy, Pavel B.; Maxwell, Adam D.; Kreider, Wayne; Bailey, Michael R.; Sapozhnikov, Oleg A.

Various clinical applications of high intensity focused ultrasound (HIFU) have different requirements on the pressure level and degree of nonlinear waveform distortion at the focus. Applications that utilize nonlinear waves with developed shocks are of growing interest, for example, for mechanical disintegration as well as for accelerated thermal ablation oftissue. In this work, an inverse problem of determining transducer parameters to enable formation of shockswith desired amplitude at the focus is solved. The solution was obtained by performing multipledirect simulations of the parabolic Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation for various parameters of the source. It is shown that results obtained within the parabolic approximation can be used to describe the focal region of single element spherical sourcesas well as complex transducer arrays. It is also demonstrated that the focal pressure level at which fully developed shocksare formed mainly depends on the focusing angle of the source and only slightly depends on its aperture and operating frequency. Using the simulation results, a 256-element HIFU array operating at 1.5 MHz frequency was designed for a specific application of boiling-histotripsy that relies on the presence of 90-100 MPa shocks at the focus. The size of the array elements and focusing angle of the array were chosen to satisfy technical limitations on the intensity at the array elements and desired shock amplitudes in the focal waveform. Focus steering capabilities of the array were analysed using an open-source T-Array software developed at Moscow State University.

Scattering of the field of a multi-element phased array by human ribs

NASA Astrophysics Data System (ADS)

Gélat, P.; ter Haar, G.; Saffari, N.

2012-03-01

The efficacy of high intensity focused ultrasound (HIFU) for the non-invasive treatment of cancer has been demonstrated for a range of different cancers including those of the liver, kidney, prostate and breast. As a non-invasive focused therapy, HIFU offers considerable advantages over other techniques such as chemotherapy and surgical resection, in terms of invasiveness and risk of harmful side effects. Despite its advantages, however, there are a number of significant challenges currently hindering its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the ribcage to induce tissue necrosis at the required foci whilst minimising the formation of side lobes. Multielement random arrays are currently showing great promise in overcoming the limitations of single-element transducers. Nevertheless, successfully treating a patient for liver tumours requires a thorough understanding of the way in which the ultrasonic pressure field from a HIFU array is scattered by the ribcage. A mesh of quadratic pressure patches was generated using CT scan data for ribs nine to twelve on the right side. A boundary element approach based on a Generalised Minimal Residual (GMRES) implementation of the Burton-Miller formulation was used, in conjunction with phase conjugation techniques to focus the field of a 256-element random HIFU array past the ribs at both intercostal and transcostal treatment locations. This method has the advantage of accounting for full effects of scattering and diffraction in three dimensions under continuous wave excitation.

Advancements in DEPMOSFET device developments for XEUS

NASA Astrophysics Data System (ADS)

Treis, J.; Bombelli, L.; Eckart, R.; Fiorini, C.; Fischer, P.; Hälker, O.; Herrmann, S.; Lechner, P.; Lutz, G.; Peric, I.; Porro, M.; Richter, R. H.; Schaller, G.; Schopper, F.; Soltau, H.; Strüder, L.; Wölfel, S.

2006-06-01

DEPMOSFET based Active Pixel Sensor (APS) matrices are a new detector concept for X-ray imaging spectroscopy missions. They can cope with the challenging requirements of the XEUS Wide Field Imager and combine excellent energy resolution, high speed readout and low power consumption with the attractive feature of random accessibility of pixels. From the evaluation of first prototypes, new concepts have been developed to overcome the minor drawbacks and problems encountered for the older devices. The new devices will have a pixel size of 75 μm × 75 μm. Besides 64 × 64 pixel arrays, prototypes with a sizes of 256 × 256 pixels and 128 × 512 pixels and an active area of about 3.6 cm2 will be produced, a milestone on the way towards the fully grown XEUS WFI device. The production of these improved devices is currently on the way. At the same time, the development of the next generation of front-end electronics has been started, which will permit to operate the sensor devices with the readout speed required by XEUS. Here, a summary of the DEPFET capabilities, the concept of the sensors of the next generation and the new front-end electronics will be given. Additionally, prospects of new device developments using the DEPFET as a sensitive element are shown, e.g. so-called RNDR-pixels, which feature repetitive non-destructive readout to lower the readout noise below the 1 e - ENC limit.

The recent and prospective developments of cooled IR FPAs for double application at Electron NRI

NASA Astrophysics Data System (ADS)

Arutunov, V. A.; Vasilyev, I. S.; Ivanov, V. G.; Prokofyev, A. E.

2003-09-01

The recent and prospective developments of monolithic silicon IR-Schottky-barrier staring focal plane arrays (IR SB FPAs), photodetector assembly, and digital thermal imaging cameras (TICs) at Electron National Research Institute (Electron NRI) are considered. Basic parameters for IR SB FPAs with 256x256 and 512x512 pixels, and TICs based on these arrays are presented. The problems emerged while proceeding from the developments of IR SB FPAs for the wavelength range from 3 μm to 5 μm to the developments of those ones for xLWIR range are indicated (an abrupt increase in the level of background architecture). Possibility for further improvement in basic parameters of IR SB FPAs are discussed (a decrease in threshold signal power down to 0.5-1.0"1013 W/element with an increase in quantum efficiency, a decrease in output noise and proceeding to Schottky barriers of degenerated semiconductor/silicon heterojunction, and implementation of these array parameters in photodetector assembly with improved thermal background shielding taking into consideration an optical structure of TIC for concrete application). It is concluded that relative simplicity of the technology and expected low cost of monolithic silicon IR SB FPAs with basic parameters compared with hybrid IR FPAs for the wavelength ranges from 3 μm to 5 μm and from 8 μm to 12 μm maintain large monolithic IR SB FPAs as a basis for developments of double application digital TICs in the Russian Federation.

The Visible Imaging System (VIS) for the Polar Spacecraft

NASA Technical Reports Server (NTRS)

Frank, L. A.; Sigwarth, J. B.; Craven, J. D.; Cravens, J. P.; Dolan, J. S.; Dvorsky, M. R.; Hardebeck, P. K.; Harvey, J. D.; Muller, D. W.

1995-01-01

The Visible Imaging System (VIS) is a set of three low-light-level cameras to be flown on the POLAR spacecraft of the Global Geospace Science (GGS) program which is an element of the International Solar-Terrestrial Physics (ISTP) campaign. Two of these cameras share primary and some secondary optics and are designed to provide images of the nighttime auroral oval at visible wavelengths. A third camera is used to monitor the directions of the fields-of-view of these sensitive auroral cameras with respect to sunlit Earth. The auroral emissions of interest include those from N+2 at 391.4 nm, 0 I at 557.7 and 630.0 nm, H I at 656.3 nm, and 0 II at 732.0 nm. The two auroral cameras have different spatial resolutions. These resolutions are about 10 and 20 km from a spacecraft altitude of 8 R(sub e). The time to acquire and telemeter a 256 x 256-pixel image is about 12 s. The primary scientific objectives of this imaging instrumentation, together with the in-situ observations from the ensemble of ISTP spacecraft, are (1) quantitative assessment of the dissipation of magnetospheric energy into the auroral ionosphere, (2) an instantaneous reference system for the in-situ measurements, (3) development of a substantial model for energy flow within the magnetosphere, (4) investigation of the topology of the magnetosphere, and (5) delineation of the responses of the magnetosphere to substorms and variable solar wind conditions.

Mutagenicity evaluation of forty-one metal salts by the umu test.

PubMed

Yamamoto, Akiko; Kohyama, Yuko; Hanawa, Takao

2002-01-01

Metallic biomaterials implanted in a human body may corrode and wear, releasing metal ions and debris which may induce adverse reactions such as inflammation, allergy, neoplastic formation, developmental malformation, etc. Mutagenicity is a very fundamental and important toxicity related to carcinogenicity and reproductive/developmental toxicity because the damages to genes or DNA can be a cause of carcinogenesis and developmental abnormalities. However, available mutagenic data on metallic ions and compounds are restricted to the number of elements. Therefore, to obtain the systematic data necessary for metal ion mutagenicity, 41 metal salts encompassing 36 metals and 5 metallic elements tested with different valences, were evaluated on their mutagenicity by a microbial test, the umu test. As a result, K(2)Cr(2)O(7), RhCl(3), IrCl(4), and MgCl(2) are positive without metabolic activation. Concentrations having the maximum mutagenic effect (C(max)) are 9.65 x 10(-5), 1.00 x 10(-4), 3.11 x 10(-3), 4.12 x 10(-3) mol. L(-1), respectively. CuCl(2), VCl(3), CuCl, RhCl(3), K(2)Cr(2)O(7), and IrCl(4) are positive with metabolic activation by S-9 mix with C(max) of 1.60 x 10(-5), 3.91 x 10(-5), 1.57 x 10(-4), 2.00 x 10(-4), 3.86 x 10(-4), 1.56 x 10(-2) mol. L(-1), respectively. Thirty-five metal salts were negative for tests performed both with and without metabolic activation, whereas it was impossible to evaluate the mutagenicity of MoCl(5) and ZrCl(4) by the umu test because of their colorimetric reaction to testing reagents. Copyright 2001 John Wiley & Sons, Inc.

Transcriptional regulation of human papillomavirus type 18 P105 promoter by the co-activator CBP.

PubMed

Valencia-Hernández, Armando; Cuevas-Bennett, Christian; Garrido, Efraín

2007-01-01

Human papillomaviruses (HPVs) are the etiological agents of cervical cancer, with HPV-16 and 18 being the representative types of the higher risk group. The expression of the viral genes with transforming activity (E6 and E7) is controlled by the upstream regulatory region (URR), a segment of the viral genome that contains elements recognized by several transcription factors. We have analyzed the participation of the cellular co-activator CBP on the transcriptional regulation of the HPV-18 URR. We generated mutants and 5' end deletion constructs derived from the HPV-18 URR and evaluated their transcriptional activity performing transient co-transfection assays on C-33A cells with a plasmid that over-expresses the co-activator CBP. We also performed quantitative chromatin immunoprecipitation assays to analyze the participation of the co-activator CBP on the HPV-18 P105 promoter. Our results demonstrate that in C-33A cells CBP acts as a strong activator of the HPV-18 P105 promoter by a mechanism that depends on the integrity of the SP1-binding site, directly correlating with the acetylation of the histone H3 that is involved in nucleosomal stability. We propose a mechanism of regulation of the HPV-18 P105 promoter by the cellular co-activator CBP, recruited by the transcription factor SP1. (c) 2008 S. Karger AG, Basel

Association Between Traumatic Brain Injury-Related Brain Lesions and Long-term Caregiver Burden.

PubMed

Guevara, Andrea Brioschi; Demonet, Jean-Francois; Polejaeva, Elena; Knutson, Kristine M; Wassermann, Eric M; Grafman, Jordan; Krueger, Frank

2016-01-01

To investigate the association between traumatic brain injury (TBI)-related brain lesions and long-term caregiver burden in relation to dysexecutive syndrome. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. A total of 256 participants: 105 combat veterans with TBI, 23 healthy control combat veterans (HCv), and 128 caregivers. Caregiver burden assessed by the Zarit Burden Interview at 40 years postinjury. Participants with penetrating TBI were compared with HCv on perceived caregiver burden and neuropsychological assessment measures. Data of computed tomographic scans (overlay lesion maps of participants with a penetrating TBI whose caregivers have a significantly high burden) and behavioral statistical analyses were combined to identify brain lesions associated with caregiver burden. Burden was greater in caregivers of veterans with TBI than in caregivers of HCv. Caregivers of participants with lesions affecting cognitive and behavioral indicators of dysexecutive syndrome (ie, left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex) showed greater long-term burden than caregivers of participants with lesions elsewhere in the brain. The TBI-related brain lesions have a lasting effect on long-term caregiver burden due to cognitive and behavioral factors associated with dysexecutive syndrome.

In vitro biomechanical properties, fluorescence imaging, surface-enhanced Raman spectroscopy, and photothermal therapy evaluation of luminescent functionalized CaMoO4:Eu@Au hybrid nanorods on human lung adenocarcinoma epithelial cells

PubMed Central

Li, Qifei; Parchur, Abdul K.; Zhou, Anhong

2016-01-01

Abstract Highly dispersible Eu3+-doped CaMoO4@Au-nanorod hybrid nanoparticles (HNPs) exhibit optical properties, such as plasmon resonances in the near-infrared region at 790 nm and luminescence at 615 nm, offering multimodal capabilities: fluorescence imaging, surface-enhanced Raman spectroscopy (SERS) detection and photothermal therapy (PTT). HNPs were conjugated with a Raman reporter (4-mercaptobenzoic acid), showing a desired SERS signal (enhancement factor 5.0 × 105). The HNPs have a heat conversion efficiency of 25.6%, and a hyperthermia temperature of 42°C could be achieved by adjusting either concentration of HNPs, or laser power, or irradiation time. HNPs were modified with antibody specific to cancer biomarker epidermal growth factor receptor, then applied to human lung cancer (A549) and mouse hepatocyte cells (AML12), and in vitro PTT effect was studied. In addition, the biomechanical properties of A549 cells were quantified using atomic force microscopy. This study shows the potential applications of these HNPs in fluorescence imaging, SERS detection, and PTT with good photostability and biocompatibility. PMID:27877887

Toward a microfluidic-based rapid amylase assay system.

PubMed

Holmes, Richard J; Summersgil, Philip; Ryan, Timothy; Brown, Bernard J Treves; Mockbil, Amal; Grieve, Bruce D; Fielden, Peter R

2009-08-01

This article describes work into a prototype system for the assay of amylase, using microfludic technologies. The new system has a significantly shorter cycle time than the current laboratory methods, which generally use microtitre plates, yet is capable of generating significantly superior results. As such, we have shown that sensitivity is enhanced by a factor of 10 in the standard assay trials, and by a factor of 2 in the real-sample lab trials. In both assays, the use of a microreactor system reduced the reaction time by a factor of 6.2, from 20 min incubation to 3.2 min. Basing the conclusion on the Megazyme Cerealpha Standard Method, and using the Cerealpha units as a measure of assay efficiency, the typical response for the microfluidic assay was shown to be 1.0 x 10(-3) CU/mL (standard deviation [SD] 2.5 x 10(-4) CU/mL), compared to 2.56 x 10(-4) CU/mL (SD 5.94 x 10(-5) CU/mL) for the standard macroassay. It is believed that this improvement in the reaction schematics is due to the inherent advantages of microfluidic devices such as superior mixing, higher thermal efficiency, and enhanced reaction kinetics.

Comparison of soft-input-soft-output detection methods for dual-polarized quadrature duobinary system

NASA Astrophysics Data System (ADS)

Chang, Chun; Huang, Benxiong; Xu, Zhengguang; Li, Bin; Zhao, Nan

2018-02-01

Three soft-input-soft-output (SISO) detection methods for dual-polarized quadrature duobinary (DP-QDB), including maximum-logarithmic-maximum-a-posteriori-probability-algorithm (Max-log-MAP)-based detection, soft-output-Viterbi-algorithm (SOVA)-based detection, and a proposed SISO detection, which can all be combined with SISO decoding, are presented. The three detection methods are investigated at 128 Gb/s in five-channel wavelength-division-multiplexing uncoded and low-density-parity-check (LDPC) coded DP-QDB systems by simulations. Max-log-MAP-based detection needs the returning-to-initial-states (RTIS) process despite having the best performance. When the LDPC code with a code rate of 0.83 is used, the detecting-and-decoding scheme with the SISO detection does not need RTIS and has better bit error rate (BER) performance than the scheme with SOVA-based detection. The former can reduce the optical signal-to-noise ratio (OSNR) requirement (at BER=10-5) by 2.56 dB relative to the latter. The application of the SISO iterative detection in LDPC-coded DP-QDB systems makes a good trade-off between requirements on transmission efficiency, OSNR requirement, and transmission distance, compared with the other two SISO methods.

49 CFR 256.11 - Applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... execution and be signed by the Chief Executive Officer of the applicant or by the applicant, where the... TRANSPORTATION FINANCIAL ASSISTANCE FOR RAILROAD PASSENGER TERMINALS Regulations Governing Applications for and Disbursement of Financial Assistance § 256.11 Applications. (a) Incorporation by reference in application of...

46 CFR 153.256 - Trunks, domes, and openings of cargo tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Equipment Cargo Tanks § 153.256 Trunks, domes, and openings of cargo tanks. (a) The hatch of a cargo tank... uppermost part of the tank, extending above the weatherdeck; (2) Its hatch at the top of the trunk or dome...

46 CFR 153.256 - Trunks, domes, and openings of cargo tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Equipment Cargo Tanks § 153.256 Trunks, domes, and openings of cargo tanks. (a) The hatch of a cargo tank... uppermost part of the tank, extending above the weatherdeck; (2) Its hatch at the top of the trunk or dome...

46 CFR 153.256 - Trunks, domes, and openings of cargo tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Equipment Cargo Tanks § 153.256 Trunks, domes, and openings of cargo tanks. (a) The hatch of a cargo tank... uppermost part of the tank, extending above the weatherdeck; (2) Its hatch at the top of the trunk or dome...

46 CFR 153.256 - Trunks, domes, and openings of cargo tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Equipment Cargo Tanks § 153.256 Trunks, domes, and openings of cargo tanks. (a) The hatch of a cargo tank... uppermost part of the tank, extending above the weatherdeck; (2) Its hatch at the top of the trunk or dome...

46 CFR 153.256 - Trunks, domes, and openings of cargo tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Equipment Cargo Tanks § 153.256 Trunks, domes, and openings of cargo tanks. (a) The hatch of a cargo tank... uppermost part of the tank, extending above the weatherdeck; (2) Its hatch at the top of the trunk or dome...

37 CFR 256.1 - General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES ADJUSTMENT OF ROYALTY FEE FOR CABLE COMPULSORY LICENSE § 256.1 General. This part establishes adjusted terms and rates for royalty payments in accordance with the provisions of 17...

50 CFR 216.256 - Applications for Letters of Authorization.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to Conducting Precision Strike Weapon Missions in the Gulf of Mexico § 216.256 Applications for Letters of Authorization. To incidentally take...

Chemistry of the superheavy elements.

PubMed

Schädel, Matthias

2015-03-13

The quest for superheavy elements (SHEs) is driven by the desire to find and explore one of the extreme limits of existence of matter. These elements exist solely due to their nuclear shell stabilization. All 15 presently 'known' SHEs (11 are officially 'discovered' and named) up to element 118 are short-lived and are man-made atom-at-a-time in heavy ion induced nuclear reactions. They are identical to the transactinide elements located in the seventh period of the periodic table beginning with rutherfordium (element 104), dubnium (element 105) and seaborgium (element 106) in groups 4, 5 and 6, respectively. Their chemical properties are often surprising and unexpected from simple extrapolations. After hassium (element 108), chemistry has now reached copernicium (element 112) and flerovium (element 114). For the later ones, the focus is on questions of their metallic or possibly noble gas-like character originating from interplay of most pronounced relativistic effects and electron-shell effects. SHEs provide unique opportunities to get insights into the influence of strong relativistic effects on the atomic electrons and to probe 'relativistically' influenced chemical properties and the architecture of the periodic table at its farthest reach. In addition, they establish a test bench to challenge the validity and predictive power of modern fully relativistic quantum chemical models. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Collective intelligence for control of distributed dynamical systems

NASA Astrophysics Data System (ADS)

Wolpert, D. H.; Wheeler, K. R.; Tumer, K.

2000-03-01

We consider the El Farol bar problem, also known as the minority game (W. B. Arthur, The American Economic Review, 84 (1994) 406; D. Challet and Y. C. Zhang, Physica A, 256 (1998) 514). We view it as an instance of the general problem of how to configure the nodal elements of a distributed dynamical system so that they do not "work at cross purposes", in that their collective dynamics avoids frustration and thereby achieves a provided global goal. We summarize a mathematical theory for such configuration applicable when (as in the bar problem) the global goal can be expressed as minimizing a global energy function and the nodes can be expressed as minimizers of local free energy functions. We show that a system designed with that theory performs nearly optimally for the bar problem.

MULTI-CORE AND OPTICAL PROCESSOR RELATED APPLICATIONS RESEARCH AT OAK RIDGE NATIONAL LABORATORY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barhen, Jacob; Kerekes, Ryan A; ST Charles, Jesse Lee

2008-01-01

High-speed parallelization of common tasks holds great promise as a low-risk approach to achieving the significant increases in signal processing and computational performance required for next generation innovations in reconfigurable radio systems. Researchers at the Oak Ridge National Laboratory have been working on exploiting the parallelization offered by this emerging technology and applying it to a variety of problems. This paper will highlight recent experience with four different parallel processors applied to signal processing tasks that are directly relevant to signal processing required for SDR/CR waveforms. The first is the EnLight Optical Core Processor applied to matched filter (MF) correlationmore » processing via fast Fourier transform (FFT) of broadband Dopplersensitive waveforms (DSW) using active sonar arrays for target tracking. The second is the IBM CELL Broadband Engine applied to 2-D discrete Fourier transform (DFT) kernel for image processing and frequency domain processing. And the third is the NVIDIA graphical processor applied to document feature clustering. EnLight Optical Core Processor. Optical processing is inherently capable of high-parallelism that can be translated to very high performance, low power dissipation computing. The EnLight 256 is a small form factor signal processing chip (5x5 cm2) with a digital optical core that is being developed by an Israeli startup company. As part of its evaluation of foreign technology, ORNL's Center for Engineering Science Advanced Research (CESAR) had access to a precursor EnLight 64 Alpha hardware for a preliminary assessment of capabilities in terms of large Fourier transforms for matched filter banks and on applications related to Doppler-sensitive waveforms. This processor is optimized for array operations, which it performs in fixed-point arithmetic at the rate of 16 TeraOPS at 8-bit precision. This is approximately 1000 times faster than the fastest DSP available today. The optical core performs the matrix-vector multiplications, where the nominal matrix size is 256x256. The system clock is 125MHz. At each clock cycle, 128K multiply-and-add operations per second (OPS) are carried out, which yields a peak performance of 16 TeraOPS. IBM Cell Broadband Engine. The Cell processor is the extraordinary resulting product of 5 years of sustained, intensive R&D collaboration (involving over $400M investment) between IBM, Sony, and Toshiba. Its architecture comprises one multithreaded 64-bit PowerPC processor element (PPE) with VMX capabilities and two levels of globally coherent cache, and 8 synergistic processor elements (SPEs). Each SPE consists of a processor (SPU) designed for streaming workloads, local memory, and a globally coherent direct memory access (DMA) engine. Computations are performed in 128-bit wide single instruction multiple data streams (SIMD). An integrated high-bandwidth element interconnect bus (EIB) connects the nine processors and their ports to external memory and to system I/O. The Applied Software Engineering Research (ASER) Group at the ORNL is applying the Cell to a variety of text and image analysis applications. Research on Cell-equipped PlayStation3 (PS3) consoles has led to the development of a correlation-based image recognition engine that enables a single PS3 to process images at more than 10X the speed of state-of-the-art single-core processors. NVIDIA Graphics Processing Units. The ASER group is also employing the latest NVIDIA graphical processing units (GPUs) to accelerate clustering of thousands of text documents using recently developed clustering algorithms such as document flocking and affinity propagation.« less

ESTCP Cost and Performance Report (UX-9909)

DTIC Science & Technology

2006-06-01

watts per square centimeter vii ACKNOWLEDGEMENTS We would like to express appreciation to John Schiavone of Sparta Inc, for his efforts...navsea.navy.mil Project Manager John Schiavone Sparta, Inc. 6000 Technology Drive, Building 3 Huntsville, AL 35805 (256) 837-5282, Ext. 2416 (256) 890

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2014 CFR

2014-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan... facilities, and (4) Development of schedules of implementation. (d) The State plan should encourage private...

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2012 CFR

2012-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan... facilities, and (4) Development of schedules of implementation. (d) The State plan should encourage private...

40 CFR 256.42 - Recommendations for assuring facility development.

Code of Federal Regulations, 2013 CFR

2013-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Facility Planning and Implementation § 256.42 Recommendations for assuring facility development. (a) The State plan... facilities, and (4) Development of schedules of implementation. (d) The State plan should encourage private...

49 CFR 256.13 - Review and approval of applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... local public and private investment, by transportation carriers and others, in improved intercity and local public transportation facilities and services; (7) Encourage the preservation of railroad... 49 Transportation 4 2010-10-01 2010-10-01 false Review and approval of applications. 256.13...

30 CFR 256.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF SULPHUR OR OIL AND GAS IN THE OUTER CONTINENTAL SHELF Outer Continental Shelf Oil, Gas, and Sulphur Management, General § 256.1... Secretary of the Interior (Secretary) will exercise the authority to administer a leasing program for oil...

PATCH image processor user's manual

NASA Technical Reports Server (NTRS)

Nieves, M. J. (Principal Investigator)

1980-01-01

The patch image processor extracts patches in various size (32 x 32, 64 x 64, 128 x 128, and 256 x 256 pixels) from full frame LANDSAT imagery data. With the patches that are extracted, a patch image mosaic is created in the image processing system, IMDACS, format.

17 CFR 256.305 - Structures and improvements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... provided for machinery, apparatus, or other equipment of the company shall be charged to the same account... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Service Company Property Accounts § 256.305 Structures and...

Highly sensitive and area-efficient CMOS image sensor using a PMOSFET-type photodetector with a built-in transfer gate

NASA Astrophysics Data System (ADS)

Seo, Sang-Ho; Kim, Kyoung-Do; Kong, Jae-Sung; Shin, Jang-Kyoo; Choi, Pyung

2007-02-01

In this paper, a new CMOS image sensor is presented, which uses a PMOSFET-type photodetector with a transfer gate that has a high and variable sensitivity. The proposed CMOS image sensor has been fabricated using a 0.35 μm 2-poly 4- metal standard CMOS technology and is composed of a 256 × 256 array of 7.05 × 7.10 μm pixels. The unit pixel has a configuration of a pseudo 3-transistor active pixel sensor (APS) with the PMOSFET-type photodetector with a transfer gate, which has a function of conventional 4-transistor APS. The generated photocurrent is controlled by the transfer gate of the PMOSFET-type photodetector. The maximum responsivity of the photodetector is larger than 1.0 × 10 3 A/W without any optical lens. Fabricated 256 × 256 CMOS image sensor exhibits a good response to low-level illumination as low as 5 lux.

Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5.

PubMed

Roche, Jennifer Virginia; Survery, Sabeen; Kreida, Stefan; Nesverova, Veronika; Ampah-Korsah, Henry; Gourdon, Maria; Deen, Peter M T; Törnroth-Horsefield, Susanna

2017-09-01

The interaction between the renal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein LIP5 targets AQP2 to multivesicular bodies and facilitates lysosomal degradation. This interaction is part of a process that controls AQP2 apical membrane abundance in a vasopressin-dependent manner, allowing for urine volume adjustment. Vasopressin regulates phosphorylation at four sites within the AQP2 C terminus (Ser 256 , Ser 261 , Ser 264 , and Thr 269 ), of which Ser 256 is crucial and sufficient for AQP2 translocation from storage vesicles to the apical membrane. However, whether AQP2 phosphorylation modulates AQP2-LIP5 complex affinity is unknown. Here we used far-Western blot analysis and microscale thermophoresis to show that the AQP2 binds LIP5 in a phosphorylation-dependent manner. We constructed five phospho-mimicking mutants (S256E, S261E, S264E, T269E, and S256E/T269E) and a C-terminal truncation mutant (ΔP242) that lacked all phosphorylation sites but retained a previously suggested LIP5-binding site. CD spectroscopy indicated that wild-type AQP2 and the phospho-mimicking mutants had similar overall structure but displayed differences in melting temperatures possibly arising from C-terminal conformational changes. Non-phosphorylated AQP2 bound LIP5 with the highest affinity, whereas AQP2-ΔP242 had 20-fold lower affinity as determined by microscale thermophoresis. AQP2-S256E, S261E, T269E, and S256E/T269E all had reduced affinity. This effect was most prominent for AQP2-S256E, which fits well with its role in apical membrane targeting. AQP2-S264E had affinity similar to non-phosphorylated AQP2, possibly indicating a role in exosome excretion. Our data suggest that AQP2 phosphorylation allosterically controls its interaction with LIP5, illustrating how altered affinities to interacting proteins form the basis for regulation of AQP2 trafficking by post-translational modifications. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Functional and Structural Characterization of Purine Nucleoside Phosphorylase from Kluyveromyces lactis and Its Potential Applications in Reducing Purine Content in Food

PubMed Central

Mahor, Durga; Priyanka, Anu; Prasad, Gandham S; Thakur, Krishan Gopal

2016-01-01

Consumption of foods and beverages with high purine content increases the risk of hyperuricemia, which causes gout and can lead to cardiovascular, renal, and other metabolic disorders. As patients often find dietary restrictions challenging, enzymatically lowering purine content in popular foods and beverages offers a safe and attractive strategy to control hyperuricemia. Here, we report structurally and functionally characterized purine nucleoside phosphorylase (PNP) from Kluyveromyces lactis (KlacPNP), a key enzyme involved in the purine degradation pathway. We report a 1.97 Å resolution crystal structure of homotrimeric KlacPNP with an intrinsically bound hypoxanthine in the active site. KlacPNP belongs to the nucleoside phosphorylase-I (NP-I) family, and it specifically utilizes 6-oxopurine substrates in the following order: inosine > guanosine > xanthosine, but is inactive towards adenosine. To engineer enzymes with broad substrate specificity, we created two point variants, KlacPNPN256D and KlacPNPN256E, by replacing the catalytically active Asn256 with Asp and Glu, respectively, based on structural and comparative sequence analysis. KlacPNPN256D not only displayed broad substrate specificity by utilizing both 6-oxopurines and 6-aminopurines in the order adenosine > inosine > xanthosine > guanosine, but also displayed reversal of substrate specificity. In contrast, KlacPNPN256E was highly specific to inosine and could not utilize other tested substrates. Beer consumption is associated with increased risk of developing gout, owing to its high purine content. Here, we demonstrate that KlacPNP and KlacPNPN256D could be used to catalyze a key reaction involved in lowering beer purine content. Biochemical properties of these enzymes such as activity across a wide pH range, optimum activity at about 25°C, and stability for months at about 8°C, make them suitable candidates for food and beverage industries. Since KlacPNPN256D has broad substrate specificity, a combination of engineered KlacPNP and other enzymes involved in purine degradation could effectively lower the purine content in foods and beverages. PMID:27768715

RALPH: An online computer program for acquisition and reduction of pulse height data

NASA Technical Reports Server (NTRS)

Davies, R. C.; Clark, R. S.; Keith, J. E.

1973-01-01

A background/foreground data acquisition and analysis system incorporating a high level control language was developed for acquiring both singles and dual parameter coincidence data from scintillation detectors at the Radiation Counting Laboratory at the NASA Manned Spacecraft Center in Houston, Texas. The system supports acquisition of gamma ray spectra in a 256 x 256 coincidence matrix (utilizing disk storage) and simultaneous operation of any of several background support and data analysis functions. In addition to special instruments and interfaces, the hardware consists of a PDP-9 with 24K core memory, 256K words of disk storage, and Dectape and Magtape bulk storage.

SecureQEMU: Emulation-Based Software Protection Providing Encrypted Code Execution and Page Granularity Code Signing

DTIC Science & Technology

2008-12-01

SHA256 DIGEST LENGTH) ) ; peAddSection(&sF i l e , " . S i g S t u b " , dwStubSecSize , dwStubSecSize ) ; 169 peSecure(&sF i l e , deqAddrSize...deqAuthPageAddrSize . s i z e ( ) /2) ∗ (8 + SHA256 DIGEST LENGTH) ) + 16 ; bCode [ 3 4 ] = ( ( char∗)&dwSize ) [ 0 ] ; bCode [ 3 5 ] = ( ( char∗)&dwSize ) [ 1...2) ∗ (8 + SHA256 DIGEST LENGTH... ) ) ; AES KEY aesKey ; unsigned char i v s a l t [ 1 6 ] , temp iv [ 1 6 ] ; 739 unsigned char ∗key

Determination of element levels in human serum: Total reflection X-ray fluorescence applications

NASA Astrophysics Data System (ADS)

Majewska, U.; Łyżwa, P.; Łyżwa, K.; Banaś, D.; Kubala-Kukuś, A.; Wudarczyk-Moćko, J.; Stabrawa, I.; Braziewicz, J.; Pajek, M.; Antczak, G.; Borkowska, B.; Góźdź, S.

2016-08-01

Deficiency or excess of elements could disrupt proper functioning of the human body and could lead to several disorders. Determination of their concentrations in different biological human fluids and tissues should become a routine practice in medical treatment. Therefore the knowledge about appropriate element concentrations in human organism is required. The purpose of this study was to determine the concentration of several elements (P, S, Cl, K, Ca, Cr, Fe, Cu, Zn, Se, Br, Rb, Pb) in human serum and to define the reference values of element concentration. Samples of serum were obtained from 105 normal presumably healthy volunteers (66 women aged between 15 and 78 years old; 39 men aged between 15 and 77 years old). Analysis has been done for the whole studied population and for subgroups by sex and age. It is probably first so a wide study of elemental composition of serum performed in the case of Świętokrzyskie region. Total reflection X-ray fluorescence (TXRF) method was used to perform the elemental analysis. Spectrometer S2 Picofox (Bruker AXS Microanalysis GmbH) was used to identify and measure elemental composition of serum samples. Finally, 1st and 3rd quartiles were accepted as minimum and maximum values of concentration reference range.

40 CFR 256.65 - Recommendations for public participation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Recommendations for public... Participation § 256.65 Recommendations for public participation. (a) State and substate planning agencies should establish an advisory group, or utilize an existing group, to provide recommendations on major policy and...

49 CFR Appendix A to Part 256 - Certificate

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Certificate A Appendix A to Part 256 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... therein are true and correct to the best of his knowledge, information and belief. [43 FR 21890, May 22...

49 CFR Appendix A to Part 256 - Certificate

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Certificate A Appendix A to Part 256 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... therein are true and correct to the best of his knowledge, information and belief. [43 FR 21890, May 22...

49 CFR Appendix A to Part 256 - Certificate

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 4 2014-10-01 2014-10-01 false Certificate A Appendix A to Part 256 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... therein are true and correct to the best of his knowledge, information and belief. [43 FR 21890, May 22...

49 CFR Appendix A to Part 256 - Certificate

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Certificate A Appendix A to Part 256 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... therein are true and correct to the best of his knowledge, information and belief. [43 FR 21890, May 22...

49 CFR Appendix A to Part 256 - Certificate

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Certificate A Appendix A to Part 256 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... therein are true and correct to the best of his knowledge, information and belief. [43 FR 21890, May 22...

40 CFR 256.06 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... § 256.06 Definitions. Terms not defined below have the meanings assigned them by section 1004 of the Act. The Act means the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act... resource recovery system or component thereof, any system, program or facility for resource conservation...

40 CFR 256.06 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... § 256.06 Definitions. Terms not defined below have the meanings assigned them by section 1004 of the Act. The Act means the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act... resource recovery system or component thereof, any system, program or facility for resource conservation...

40 CFR 256.06 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... § 256.06 Definitions. Terms not defined below have the meanings assigned them by section 1004 of the Act. The Act means the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act... resource recovery system or component thereof, any system, program or facility for resource conservation...

40 CFR 256.06 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... § 256.06 Definitions. Terms not defined below have the meanings assigned them by section 1004 of the Act. The Act means the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act... resource recovery system or component thereof, any system, program or facility for resource conservation...

40 CFR 256.06 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... § 256.06 Definitions. Terms not defined below have the meanings assigned them by section 1004 of the Act. The Act means the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act... resource recovery system or component thereof, any system, program or facility for resource conservation...

17 CFR 256.926 - Employee pensions and benefits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Employee pensions and benefits... UTILITY HOLDING COMPANY ACT OF 1935 2. Expense § 256.926 Employee pensions and benefits. This account... employee benefit programs such as medical and surgical benefits, disability benefits, life insurance...

20 CFR 632.256 - Submission of applications.

Code of Federal Regulations, 2010 CFR

2010-04-01

... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.256 Submission of applications. To the extent possible, Native American grantees will be notified of their summer youth allocation at the same time section 401 allocations are announced. The summer plan will be a...

20 CFR 632.256 - Submission of applications.

Code of Federal Regulations, 2012 CFR

2012-04-01

... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.256 Submission of applications. To the extent possible, Native American grantees will be notified of their summer youth allocation at the same time section 401 allocations are announced. The summer plan will be a...

20 CFR 632.256 - Submission of applications.

Code of Federal Regulations, 2011 CFR

2011-04-01

... NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.256 Submission of applications. To the extent possible, Native American grantees will be notified of their summer youth allocation at the same time section 401 allocations are announced. The summer plan will be a...

24 CFR 213.256 - Premiums; insurance upon completion.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Premiums; insurance upon completion... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES COOPERATIVE HOUSING MORTGAGE INSURANCE Contract Rights and Obligations-Projects § 213.256 Premiums...

256. Photocopy of drawing (1975 piping drawing by the Ralph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

256. Photocopy of drawing (1975 piping drawing by the Ralph M. Parsons Company) LIQUID OXYGEN FLOW DIAGRAM FOR THE LSB AREA, SHEET P-2 - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

17 CFR 256.426.5 - Other deductions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... deductible before determining total income before interest charges. (b) Records shall be so maintained by...) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Income and Expense Accounts § 256.426.5 Other deductions. (a) This account...

17 CFR 256.152 - Fuel stock expenses undistributed.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Fuel stock expenses... (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.152 Fuel stock expenses...

24 CFR 3282.256 - Distributor or retailer complaint handling.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Where a distributor or retailer receives a consumer complaint or other information concerning a... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Distributor or retailer complaint... Distributor Responsibilities § 3282.256 Distributor or retailer complaint handling. (a) When a distributor or...

24 CFR 3282.256 - Distributor or dealer complaint handling.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Where a distributor or dealer receives a consumer complaint or other information concerning a... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Distributor or dealer complaint... Distributor Responsibilities § 3282.256 Distributor or dealer complaint handling. (a) When a distributor or...

24 CFR 3282.256 - Distributor or dealer complaint handling.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Where a distributor or dealer receives a consumer complaint or other information concerning a... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Distributor or dealer complaint... Distributor Responsibilities § 3282.256 Distributor or dealer complaint handling. (a) When a distributor or...

24 CFR 3282.256 - Distributor or dealer complaint handling.

Code of Federal Regulations, 2013 CFR

2013-04-01

...) Where a distributor or dealer receives a consumer complaint or other information concerning a... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Distributor or dealer complaint... Distributor Responsibilities § 3282.256 Distributor or dealer complaint handling. (a) When a distributor or...

24 CFR 3282.256 - Distributor or dealer complaint handling.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Where a distributor or dealer receives a consumer complaint or other information concerning a... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Distributor or dealer complaint... Distributor Responsibilities § 3282.256 Distributor or dealer complaint handling. (a) When a distributor or...

17 CFR 256.215 - Appropriated retained earnings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Appropriated retained earnings... UTILITY HOLDING COMPANY ACT OF 1935 Liabilities and Other Credit Accounts § 256.215 Appropriated retained earnings. This account shall include the amount of retained earnings which has been appropriated or set...

l-Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor-bearing rats.

PubMed

Martins, Heber Amilcar; Bazotte, Roberto Barbosa; Vicentini, Geraldo Emilio; Lima, Mariana Machado; Guarnier, Flavia Alessandra; Hermes-Uliana, Catchia; Frez, Flavia Cristina Vieira; Bossolani, Gleison Daion Piovezana; Fracaro, Luciane; Fávaro, Larissa Dos Santos; Manzano, Mariana Inocêncio; Zanoni, Jacqueline Nelisis

2017-03-01

We evaluated the effects of supplementation with oral l-glutamine in Walker-256 tumor-bearing rats. A total of 32 male Wistar rats aged 54 days were randomly divided into four groups: rats without Walker-256 tumor, that is, control rats (C group); control rats supplemented with l-glutamine (CG group); Walker-256 tumor rats without l-glutamine supplementation (WT group); and WT rats supplemented with l-glutamine (WTG group). l-Glutamine was incorporated into standard food at a proportion of 2 g/100 g (2%). After 10 days of the experimental period, the jejunum and duodenum were removed and processed. Protein expression levels of key enzymes of gluconeogenesis, that is, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, were analyzed by western blot and immunohistochemical techniques. In addition, plasma corticosterone, glucose, insulin, and urea levels were evaluated. The WTG group showed significantly increased plasma glucose and insulin levels ( p < 0.05); however, plasma corticosterone and urea remained unchanged. Moreover, the WTG group showed increased immunoreactive staining for jejunal phosphoenolpyruvate carboxykinase and increased expression of duodenal glucose-6-phosphatase. Furthermore, the WTG group presented with less intense cancer cachexia and slower tumor growth. These results could be attributed, at least partly, to increased intestinal gluconeogenesis and insulinemia, and better glycemia maintenance during fasting in Walker-256 tumor rats on a diet supplemented with l-glutamine.

Novel multichannel surface plasmon resonance photonic crystal fiber biosensor

NASA Astrophysics Data System (ADS)

Hameed, Mohamed Farhat O.; Alrayk, Yassmin K. A.; Shaalan, A. A.; El Deeb, Walid S.; Obayya, S. S. A.

2016-04-01

In this paper, a novel design of highly sensitive biosensor based on photonic crystal fiber is presented and analyzed using full vectorial finite element method. The suggested design depends on using silver layer as a plasmonic active material coated by a gold layer to protect silver oxidation. The reported sensor is based on the detection using the quasi transverse electric (TE) and quasi transverse magnetic (TM) modes which offers the possibility of multi-channel/multi-analyte sensing. The sensor geometrical parameters are optimized to achieve high sensitivity for the two polarized modes. High refractive index sensitivity of about 4750 nm/RIU (refractive index unit) and 4300 nm/RIU with corresponding resolutions of 2.1×10-5 RIU, and 2.33×10-5 RIU can be obtained for the quasi TM and quasi TE modes, respectively.