Visualizing Concordance of Sets

DTIC Science & Technology

2006-01-01

Elements Filtering with Human Muscular Dystrophy Dataset of 21 sets and 163 elements. 4.1.4 Diagram Ordering using the Rank-by-Feature Framework...Proceedings of Advanced Visual Interfaces, pp. 110-119, 2000. [4] R. A. Becker and W. S. Cleveland, "Brushing Scatterplots," Technometrics, vol. 29, pp. 127

76 FR 55577 - Findings of Failure To Submit a Complete State Implementation Plan for Section 110(a) Pertaining...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... Failure To Submit a Complete State Implementation Plan for Section 110(a) Pertaining to the 2006 Fine... submission for some or all of these specific requirements. The finding of failure to submit for some or all... making a finding of failure to submit SIPs, or elements of SIPs, required by the CAA, where states have...

Discovery of radioactive silver ((110m)Ag) in spiders and other fauna in the terrestrial environment after the meltdown of Fukushima Dai-ichi nuclear power plant.

PubMed

Nakanishi, Hiromi; Mori, Atsushi; Takeda, Kouki; Tanaka, Houdo; Kobayashi, Natsuko; Tanoi, Keitaro; Yamakawa, Takashi; Mori, Satoshi

2015-01-01

Six months after the explosion of TEPCO's Fukushima Dai-ichi nuclear power plant, radioactive silver ((110m)Ag), was detected in concentrations of 3754 Bq/kg in Nephila clavata (the orb-web spider; Joro-gumo in Japanese) collected at Nimaibashi, Iitate village in Fukushima Prefecture, whereas (110m)Ag in the soil was 43.1 Bq/kg. A survey of 35 faunal species in the terrestrial environment during the 3.5 years after the accident showed that most of Anthropoda had two orders higher (110m)Ag in their tissues than soils, although silver is not an essential element for their life. However, tracing of the activity of (110m)Ag detected in spider Atypus karschi collected regularly at a fixed location showed that it declined much faster than the physical half-life. These results suggest that (110m)Ag was at once biologically concentrated by faunal species, especially Arthropoda, through food chain. The factors affecting the subsequent rapid decline of (110m)Ag concentration in faunal species are discussed.

Discovery of radioactive silver (110mAg) in spiders and other fauna in the terrestrial environment after the meltdown of Fukushima Dai-ichi nuclear power plant

PubMed Central

NAKANISHI, Hiromi; MORI, Atsushi; TAKEDA, Kouki; TANAKA, Houdo; KOBAYASHI, Natsuko; TANOI, Keitaro; YAMAKAWA, Takashi; MORI, Satoshi

2015-01-01

Six months after the explosion of TEPCO’s Fukushima Dai-ichi nuclear power plant, radioactive silver (110mAg), was detected in concentrations of 3754 Bq/kg in Nephila clavata (the orb-web spider; Joro-gumo in Japanese) collected at Nimaibashi, Iitate village in Fukushima Prefecture, whereas 110mAg in the soil was 43.1 Bq/kg. A survey of 35 faunal species in the terrestrial environment during the 3.5 years after the accident showed that most of Anthropoda had two orders higher 110mAg in their tissues than soils, although silver is not an essential element for their life. However, tracing of the activity of 110mAg detected in spider Atypus karschi collected regularly at a fixed location showed that it declined much faster than the physical half-life. These results suggest that 110mAg was at once biologically concentrated by faunal species, especially Arthropoda, through food chain. The factors affecting the subsequent rapid decline of 110mAg concentration in faunal species are discussed. PMID:25864469

40 CFR 52.349 - Control strategy: Carbon monoxide.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... (b) On June 25, 1996, the Governor of Colorado submitted a revision to the Colorado Springs element... the Colorado Springs element was submitted to satisfy certain requirements of part D and section 110... program for the Colorado Springs bus purchase program as a source of emissions reductions credits in the...

40 CFR 52.349 - Control strategy: Carbon monoxide.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... (b) On June 25, 1996, the Governor of Colorado submitted a revision to the Colorado Springs element... the Colorado Springs element was submitted to satisfy certain requirements of part D and section 110... program for the Colorado Springs bus purchase program as a source of emissions reductions credits in the...

40 CFR 52.349 - Control strategy: Carbon monoxide.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... (b) On June 25, 1996, the Governor of Colorado submitted a revision to the Colorado Springs element... the Colorado Springs element was submitted to satisfy certain requirements of part D and section 110... program for the Colorado Springs bus purchase program as a source of emissions reductions credits in the...

40 CFR 52.349 - Control strategy: Carbon monoxide.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... (b) On June 25, 1996, the Governor of Colorado submitted a revision to the Colorado Springs element... the Colorado Springs element was submitted to satisfy certain requirements of part D and section 110... program for the Colorado Springs bus purchase program as a source of emissions reductions credits in the...

Shape memory-based actuators and release mechanisms therefrom

NASA Technical Reports Server (NTRS)

Vaidyanathan, Rajan (Inventor); Snyder, Daniel W. (Inventor); Schoenwald, David K. (Inventor); Lam, Nhin S. (Inventor); Watson, Daniel S. (Inventor); Krishnan, Vinu B. (Inventor); Noebe, Ronald D. (Inventor)

2012-01-01

SM-based actuators (110) and release mechanisms (100) therefrom and systems (500) including one or more release mechanisms (100). The actuators (110) comprise a SM member (118) and a deformable member (140) mechanically coupled to the SM member (118) which deforms upon a shape change of the SM member triggered by a phase transition of the SM member. A retaining element (160) is mechanically coupled to the deformable member (140), wherein the retaining element (160) moves upon the shape change. Release mechanism (100) include an actuator, a rotatable mechanism (120) including at least one restraining feature (178) for restraining rotational movement of the retaining element (160) before the shape change, and at least one spring (315) that provides at least one locked spring-loaded position when the retaining element is in the restraining feature and at least one released position that is reached when the retaining element is in a position beyond the restraining feature (178). The rotatable mechanism (120) includes at least one load-bearing protrusion (310). A hitch (400) is for mechanically coupling to the load, wherein the hitch is supported on the load bearing protrusion (310) when the rotatable mechanism is in the locked spring-loaded position.

10 CFR Appendix I to Part 110 - Illustrative List of Reprocessing Plant Components Under NRC Export Licensing Authority

Code of Federal Regulations, 2010 CFR

2010-01-01

... transuranic elements. Different technical processes can accomplish this separation. However, over the years Purex has become the most commonly used and accepted process. Purex involves the dissolution of... facilities have process functions similar to each other, including: irradiated fuel element chopping, fuel...

Effect of HF Heating Array Directivity Pattern on the Frequency Response of Generated ELF/VLF.

DTIC Science & Technology

1983-01-01

radiators ....... ............ 4 1-2 HF heating array ........ ................... 9 1-3 HF heating array element ...... ................ 9 1-4 View of top...elements looking down at pyramid ....... 9 1-5 Non-planar log-periodic antenna semi-structure dimensions ............ . ....... 10 l-6a Power gain vs...22 1-8 Orientation of 4- and 8-element arrays .. ......... .. 24 1- 9 Comparison of experimental and theoretical patterns. . . 27 1-10 Directive

Predictions of the residue cross-sections for the elements Z = 113 and Z = 114

NASA Astrophysics Data System (ADS)

Bouriquet, B.; Abe, Y.; Kosenko, G.

2004-10-01

A good reproduction of experimental excitation functions is obtained for the 1 n reactions producing the elements with Z = 108, 110, 111 and 112 by the combined usage of the two-step model for fusion and the statistical decay code KEWPIE. Furthermore, the model provides reliable predictions of productions of the elements with Z = 113 and Z = 114 which will be a useful guide for plannings of experiments.

SRG110 Stirling Generator Dynamic Simulator Vibration Test Results and Analysis Correlation

NASA Technical Reports Server (NTRS)

Suarez, Vicente J.; Lewandowski, Edward J.; Callahan, John

2006-01-01

The U.S. Department of Energy (DOE), Lockheed Martin (LM), and NASA Glenn Research Center (GRC) have been developing the Stirling Radioisotope Generator (SRG110) for use as a power system for space science missions. The launch environment enveloping potential missions results in a random input spectrum that is significantly higher than historical RPS launch levels and is a challenge for designers. Analysis presented in prior work predicted that tailoring the compliance at the generator-spacecraft interface reduced the dynamic response of the system thereby allowing higher launch load input levels and expanding the range of potential generator missions. To confirm analytical predictions, a dynamic simulator representing the generator structure, Stirling convertors and heat sources was designed and built for testing with and without a compliant interface. Finite element analysis was performed to guide the generator simulator and compliant interface design so that test modes and frequencies were representative of the SRG110 generator. This paper presents the dynamic simulator design, the test setup and methodology, test article modes and frequencies and dynamic responses, and post-test analysis results. With the compliant interface, component responses to an input environment exceeding the SRG110 qualification level spectrum were all within design allowables. Post-test analysis included finite element model tuning to match test frequencies and random response analysis using the test input spectrum. Analytical results were in good overall agreement with the test results and confirmed previous predictions that the SRG110 power system may be considered for a broad range of potential missions, including those with demanding launch environments.

SRG110 Stirling Generator Dynamic Simulator Vibration Test Results and Analysis Correlation

NASA Technical Reports Server (NTRS)

Lewandowski, Edward J.; Suarez, Vicente J.; Goodnight, Thomas W.; Callahan, John

2007-01-01

The U.S. Department of Energy (DOE), Lockheed Martin (LM), and NASA Glenn Research Center (GRC) have been developing the Stirling Radioisotope Generator (SRG110) for use as a power system for space science missions. The launch environment enveloping potential missions results in a random input spectrum that is significantly higher than historical radioisotope power system (RPS) launch levels and is a challenge for designers. Analysis presented in prior work predicted that tailoring the compliance at the generator-spacecraft interface reduced the dynamic response of the system thereby allowing higher launch load input levels and expanding the range of potential generator missions. To confirm analytical predictions, a dynamic simulator representing the generator structure, Stirling convertors and heat sources were designed and built for testing with and without a compliant interface. Finite element analysis was performed to guide the generator simulator and compliant interface design so that test modes and frequencies were representative of the SRG110 generator. This paper presents the dynamic simulator design, the test setup and methodology, test article modes and frequencies and dynamic responses, and post-test analysis results. With the compliant interface, component responses to an input environment exceeding the SRG110 qualification level spectrum were all within design allowables. Post-test analysis included finite element model tuning to match test frequencies and random response analysis using the test input spectrum. Analytical results were in good overall agreement with the test results and confirmed previous predictions that the SRG110 power system may be considered for a broad range of potential missions, including those with demanding launch environments.

10 CFR Appendix O to Part 110 - Illustrative List of Fuel Element Fabrication Plant Equipment and Components Under NRC's Export...

Code of Federal Regulations, 2010 CFR

2010-01-01

... performance and safety during reactor operation. Also, in all cases precise control of processes, procedures... elements include equipment that: (1) Normally comes in direct contact with, or directly processes or... pellets; (2) Automatic welding machines especially designed or prepared for welding end caps onto the fuel...

26 CFR 1.72-5 - Expected return.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the joint and survivor annuity element 110.40 Multiple from Table I (male, age 60) 18.2 Number of... anticipatable with respect to the joint and survivor annuity element 124.80 Multiple from Table V (age 60) 24.2... annuity payments to be received annually by the multiple shown in Table I or V (whichever is applicable...

26 CFR 1.72-5 - Expected return.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the joint and survivor annuity element 110.40 Multiple from Table I (male, age 60) 18.2 Number of... anticipatable with respect to the joint and survivor annuity element 124.80 Multiple from Table V (age 60) 24.2... annuity payments to be received annually by the multiple shown in Table I or V (whichever is applicable...

26 CFR 1.72-5 - Expected return.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the joint and survivor annuity element 110.40 Multiple from Table I (male, age 60) 18.2 Number of... anticipatable with respect to the joint and survivor annuity element 124.80 Multiple from Table V (age 60) 24.2... annuity payments to be received annually by the multiple shown in Table I or V (whichever is applicable...

26 CFR 1.72-5 - Expected return.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the joint and survivor annuity element 110.40 Multiple from Table I (male, age 60) 18.2 Number of... anticipatable with respect to the joint and survivor annuity element 124.80 Multiple from Table V (age 60) 24.2... annuity payments to be received annually by the multiple shown in Table I or V (whichever is applicable...

Convergence rates for finite element problems with singularities. Part 1: Antiplane shear. [crack

NASA Technical Reports Server (NTRS)

Plunkett, R.

1980-01-01

The problem of a finite crack in an infinite medium under antiplane shear load is considered. It is shown that the nodal forces at the tip of the crack accurately gives the order of singularity, that n energy release methods can give the strength to better than 1 percent with element size 1/10 the crack length, and that nodal forces give a much better estimate of the stress field than do the elements themselves. The finite element formulation and the factoring of tridiagonal matrices are discussed.

77 FR 33380 - Approval and Promulgation of Implementation Plans; South Carolina; 110(a)(1) and (2)(E) and (G...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-06

... infrastructure elements for the 1997 and 2006 PM 2.5 NAAQS, however the subject of this notice is limited to... had submitted or failed to submit a complete SIP that provided the basic program elements of section.... The requirements that are the subject of the infrastructure rulemaking process are listed below \\1...

Surface-structure-controlled sectoral zoning of the rare earth elements in fluorite from Long Lake, New York, and Bingham, New Mexico, USA

NASA Astrophysics Data System (ADS)

Bosze, Stephanie; Rakovan, John

2002-03-01

The concentration and distribution of rare earth elements (REE) in sectorally zoned fluorite crystals from Long Lake, New York, and the Hansonburg Mining District, Bingham, New Mexico, have been studied using cathodoluminescence and synchrotron X-ray fluorescence microanalysis (SXRFMA). In cubo-octahedral samples from Long Lake, New York, Ce, Nd, Gd, Dy, Ho, Er, and Tm are preferentially partitioned into the |111| sector relative to the |100| sector. Partition coefficients (K d = concentration in |111| sector/concentration in |100| sector) range between 3.5 for Ce, to 1.4 for Tm, with a general decrease in K d as elements deviated from the ionic radius of Ca 2+, for which REE substitute in fluorite. Diffusion of the REE has occurred, as evidenced by gradual changes in composition over distances of 0.2 to 0.3 mm at sector boundaries. In Bingham samples, three different partition coefficients were determined for Dy: K d|100|/|111| = 2.83, K d |100|/|110| = 1.77, and K d |110|/|111| = 1.60. These are mean K d values for a 95% confidence interval. In another sample from the same deposit, Dy, Er, and Gd were found to be preferentially incorporated into the |100| sector relative to the |210| sector with average K d |100|/|210| of 3.1, 2.4, and 2.9, respectively. In a third sample, Nd was found to be preferentially incorporated into the |110| sector relative to the |321| sector with an average K d |110|/|321| value of 2.3. Compositional heterogeneities in a given sector (concentric zoning) have been resolved using SXRFMA but are significantly less than the concentration difference across sector boundaries. Often fluorite exists in a wide variety of morphologies, as is the case in the Hansonburg Mining District of Bingham. We suggest caution when using the REE as petrogenetic indicators because fluorite trace element chemistry can vary greatly among crystals within a deposit depending on the internal morphology of a particular crystal.

Theoretical Predictions of Cross-Sections of the Super-Heavy Elements

NASA Astrophysics Data System (ADS)

Bouriquet, B.; Kosenko, G.; Abe, Y.

The evaluation of the residue cross-sections of reactionssynthesising superheavy elements has been achieved by the combination of the two-step model for fusion and the evaporation code (KEWPIE) for survival probability. The theoretical scheme of those calculations is presented, and some encouraging results are given, together with some difficulties. With this approach, the measured excitation functions of the 1n reactions producing elements with Z=108, 110, 111 and 112 are well reproduced. Thus, the model has been used to predict the cross-sections of the reactions leading to the formation of the elements with Z=113 and Z=114.

76 FR 59090 - Approval and Promulgation of Implementation Plans; Oregon: New Source Review/Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

...EPA is proposing to approve a portion of the State Implementation Plan (SIP) revision submitted by the State of Oregon for the purpose of addressing the third element of the interstate transport provisions of Clean Air Act (CAA or the Act) section 110(a)(2)(D)(i)(II) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 and 2006 fine particulate matter (PM2.5) NAAQS. The third element of CAA section 110(a)(2)(D)(i)(II) requires that a State not interfere with any other State's required measures to prevent significant deterioration (PSD) of its air quality. EPA is also proposing to approve numerous revisions to the Oregon SIP that were submitted to EPA by the State of Oregon on October 8, 2008; October 10, 2008; March 17, 2009; June 23, 2010; December 22, 2010 and May 5, 2011. The revisions include updating Oregon's new source review (NSR) rules to be consistent with current Federal regulations and streamlining Oregon's air quality rules by clarifying requirements, removing duplicative rules, and correcting errors. The revisions were submitted in accordance with the requirements of section 110 and part D of the Act).

The Research Base for a Public Relations Curriculum: A National Survey of Topics "Essential" to a Public Relations Curriculum.

ERIC Educational Resources Information Center

Kendall, Robert; Anderson, James W.

In order to rate the importance of elements involved in a public relations curriculum, a study analyzed the responses of public relations educators from all academic associations teaching the subject as well as practitioners from all specializations. Questionnaires were sent to 544 people who rated 110 elements as not essential to essential on a…

Spectral characterization of novel ternary zinc(II) complexes containing 1,10-phenanthroline and Schiff bases derived from amino acids and salicylaldehyde-5-sulfonates

NASA Astrophysics Data System (ADS)

Boghaei, Davar M.; Gharagozlou, Mehrnaz

2007-07-01

A series of new ternary zinc(II) complexes [Zn(L 1-10)(phen)], where phen is 1,10-phenanthroline and H 2L 1-10 = tridentate Schiff base ligands derived from the condensation of amino acids (glycine, L-phenylalanine, L-valine, L-alanine, and L-leucine) and salicylaldehyde-5-sulfonates (sodium salicylaldehyde-5-sulfonate and sodium 3-methoxy-salicylaldehyde-5-sulfonate), have been synthesized. The complexes were characterized by elemental analysis, IR, UV-vis, 1H NMR, and 13C NMR spectra. The IR spectra of the complexes showed large differences between νas(COO) and νs(COO), Δ ν ( νas(COO) - νs(COO)) of 191-225 cm -1, indicating a monodentate coordination of the carboxylate group. Spectral data showed that in these ternary complexes the zinc atom is coordinated with the Schiff base ligand acts as a tridentate ONO moiety, coordinating to the metal through its phenolic oxygen, imine nitrogen, and carboxyl oxygen, and also with the neutral planar chelating ligand, 1,10-phenanthroline, coordinating through nitrogens.

Determination of major elements by wavelength-dispersive X-ray fluorescence spectrometry and trace elements by inductively coupled plasma mass spectrometry in igneous rocks from the same fused sample (110 mg)

NASA Astrophysics Data System (ADS)

Amosova, Alena A.; Panteeva, Svetlana V.; Chubarov, Victor M.; Finkelshtein, Alexandr L.

2016-08-01

The fusion technique is proposed for simultaneous determination of 35 elements from the same sample. Only 110 mg of rock sample was used to obtain fused glasses for quantitative determination of 10 major elements by wavelength dispersive X-ray fluorescence analysis, 16 rare earth elements and some other trace elements by inductively coupled plasma mass spectrometry analysis. Fusion was performed with 1.1 g of lithium metaborate and LiBr solution as the releasing agent in platinum crucible in electric furnace at 1100 °C. The certified reference materials of ultramafic, mafic, intermediate and felsic igneous rocks have been applied to obtain the calibration curves for rock-forming oxides (Na2O, MgO, Al2O3, SiO2, P2O5, K2O, CaO, TiO2, MnO, Fe2O3) and some trace elements (Ba, Sr, Zr) determination by X-ray fluorescence analysis. The repeatability does not exceed the allowable standard deviation for a wide range of concentrations. In the most cases the relative standard deviation was less than 5%. Obtained glasses were utilized for the further determination of rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and some other (Ba, Sr, Zr, Rb, Cs, Y, Nb, Hf, Ta, Th and U) trace elements by inductively coupled plasma mass spectrometry analysis with the same certified reference materials employed. The results could mostly be accepted as satisfactory. The proposed procedure essentially reduces the expenses in comparison with separate sample preparation for inductively coupled plasma mass spectrometry and X-ray fluorescence analysis.

Hybrid chip-on-board LED module with patterned encapsulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soer, Wouter Anthon; Helbing, Rene; Huang, Guan

Different wavelength conversion materials, or different concentrations of a wavelength conversion material are used to encapsulate the light emitting elements of different colors of a hybrid light emitting module. In an embodiment of this invention, second light emitting elements (170) of a particular color are encapsulated with a transparent second encapsulant (120;420;520), while first light emitting elements (160) of a different color are encapsulated with a wavelength conversion first encapsulant (110;410;510). In another embodiment of this invention, a particular second set of second and third light emitting elements (170,580) of different colors is encapsulated with a different encapsulant than anothermore » first set of first light emitting elements (160).« less

Improved Finite Element Analysis of Thick Laminated Composite Plates by the Predictor Corrector Technique and Approximation of C(1) Continuity with a New Least Squares Element

DTIC Science & Technology

1991-03-06

O= = UO’, + z¢ ,2 = C + zKT (1.7) OyV 7 _ w - =0 (1.9) 7zz = O w- + o + wZ (1.10) _ Ov Ow (.1 YZ -Oz + = y + W(. _Ou Ot, ’Ty = au + v= Uoy + Voz ...to solve for the natural frequencies and mode shapes of our problem. From eqn (2.55) the elemental stiffness matrix is [k] L [O]T A J [ Ip ] + [4]T [AI

[The direct AAS determination of micro elements in hair and nail by base-digestion].

PubMed

Ju, Hong-fang

2002-08-01

The study of micro elements is more and more extensively, and people can gain some informations by the level of micro elements in tissue. This paper tempts to dissolve hair or nail in 2 mol.L-1 NaOH and determinate nine micro elements including calcium, zinc, iron, manganese, nickel, cadmium, copper, lead and bismuth in them by base-digestion with FAAS and GFAAS. It shows that the measured value of these elements is coincident with reference articles reported, except bismuth. The elements' percent recoveries are 90.0%-110.8%. The result also shows that the level of zinc and copper in hair are higher than in nail, and the level of bismuth, cadmium and iron in hair are lower than in nail, but the level of micro elements in hair and in nail are not correlative.

The uses of synchrotron radiation sources for elemental and chemical microanalysis

USGS Publications Warehouse

Chen, J.R.; Chao, E.C.T.; Minkin, J.A.; Back, J.M.; Jones, K.W.; Rivers, M.L.; Sutton, S.R.

1990-01-01

Synchrotron radiation sources offer important features for the analysis of a material. Among these features is the ability to determine both the elemental composition of the material and the chemical state of its elements. For microscopic analysis synchrotron X-ray fluorescence (SXRF) microprobes now offer spatial resolutions of 10 ??m with minimum detection limits in the 1-10 ppm range depending on the nature of the sample and the synchrotron source used. This paper describes the properties of synchrotron radiation and their importance for elemental analysis, existing synchrotron facilities and those under construction that are optimum for SXRF microanalysis, and a number of applications including the high energy excitation of the K lines of heavy elements, microtomography, and XANES and EXAFS spectroscopies. ?? 1990.

78 FR 41311 - Approval of Air Quality Implementation Plans; Indiana; Approval of “Infrastructure” SIP With...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... Elements Required Under Sections 110(a)(1) and (2) for the 2006 24-Hour Fine Particle (PM 2.5 ) National... Indiana Nonregulatory and Quasi-Regulatory Provisions Title Indiana date EPA approval Explanation...

Device for improved air and fuel distribution to a combustor

DOEpatents

Laster, Walter R.; Schilp, Reinhard

2016-05-31

A flow conditioning device (30, 50, 70, 100, 150) for a can annular gas turbine engine, including a plurality of flow elements (32, 34, 52, 54, 72, 74, 102) disposed in a compressed air flow path (42, 60, 80, 114, 122) leading to a combustor (12), configured such that relative adjustment of at least one flow directing element (32, 52, 72, 110) with respect to an adjacent flow directing element (34, 54, 74, 112, 120) during operation of the gas turbine engine is effective to adjust a level of choking of the compressed air flow path (42, 60, 80, 114, 122).

Study on the method of improving the flashover voltage of 110kV suspension porcelain insulators based on neural network genetic algorithm

NASA Astrophysics Data System (ADS)

Zhang, Ruiqi; Cai, Li; Chen, Junwu; Wang, Luo; Tan, Xuefeng

2018-04-01

This paper presents a new method to improve 110kV porcelain insulator flashover voltage by adding a metal ring on the insulator cap, which can not only effectively reduce the field strength of the steel cap, but also reduce the tangential field intensity of the umbrella group and inhibit the development of the discharge process, thus the flashover voltage can be increased. The surface strength calculation model of 110kV porcelain insulator is established by the finite element method (FEM), and the parameters of the metal ring are designed by neural network genetic algorithm (BP-GA). Then the experiments were carried out to verify the results, and the results show that the metal ring plate under the optimum parameters can greatly improve the flashover voltage.

The Virtual Observatory Service TheoSSA: Establishing a Database of Synthetic Stellar Flux Standards II. NLTE Spectral Analysis of the OB-Type Subdwarf Feige 110

NASA Technical Reports Server (NTRS)

Rauch, T.; Rudkowski, A.; Kampka, D.; Werner, K.; Kruk, J. W.; Moehler, S.

2014-01-01

Context. In the framework of the Virtual Observatory (VO), the German Astrophysical VO (GAVO) developed the registered service TheoSSA (Theoretical Stellar Spectra Access). It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code, generally for all effective temperatures, surface gravities, and elemental compositions. We will establish a database of SEDs of flux standards that are easily accessible via TheoSSA's web interface. Aims. The OB-type subdwarf Feige 110 is a standard star for flux calibration. State-of-the-art non-local thermodynamic equilibrium stellar-atmosphere models that consider opacities of species up to trans-iron elements will be used to provide a reliable synthetic spectrum to compare with observations. Methods. In case of Feige 110, we demonstrate that the model reproduces not only its overall continuum shape from the far-ultraviolet (FUV) to the optical wavelength range but also the numerous metal lines exhibited in its FUV spectrum. Results. We present a state-of-the-art spectral analysis of Feige 110. We determined Teff =47 250 +/- 2000 K, log g=6.00 +/- 0.20, and the abundances of He, N, P, S, Ti, V, Cr, Mn, Fe, Co, Ni, Zn, and Ge. Ti, V, Mn, Co, Zn, and Ge were identified for the first time in this star. Upper abundance limits were derived for C, O, Si, Ca, and Sc. Conclusions. The TheoSSA database of theoretical SEDs of stellar flux standards guarantees that the flux calibration of astronomical data and cross-calibration between different instruments can be based on models and SEDs calculated with state-of-the-art model atmosphere codes.

76 FR 20602 - Approval and Promulgation of Implementation Plans; Texas; Proposed Disapproval of Interstate...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... state with respect to the 2006 24-hour fine particle (PM 2.5 ) national ambient air quality standards... ``Guidance on SIP Elements Required Under Sections 110(a)(1) and (2) for the 2006 24-Hour Fine Particle (PM 2...

Determination of selected trace elements in foodstuffs and biological materials by destructive neutron activation analysis.

PubMed

Bayat, I; Etehadiyan, M; Ansar, M

1995-01-01

Concentration of trace elements in Nescafé, Fariman sugar, and Sadaf turmeric and mercury content in cancerous blood were determined by radiochemical, neutron activation analysis. By this separation method levels of 110mAg, 198Au, 203Hg, 76Se, 51Cr, 24Na, 42K, 99Mo, 122Sb, 82Br, 59Fe, 60Co were measured without interference in the gamma spectroscopy. A nondestructive method has also been used for the analysis of sodium, potassium, and bromine.

Structural Characterization of POSS Siloxane Dimer and Trimer (PREPRINT)

DTIC Science & Technology

2005-11-14

68.49 (s, 1 Si); -109.77 (s, 1 Si). Elemental analysis found (theoretical): %C 50.12 (50.11); %H 7.88 (7.71). HPLC showed a single peak. Synthesis...s, 1 Si); -68.88 (s, 1 Si); -110.09 (s, 1 Si). Elemental analysis found (theoretical): %C 51.37 (51.22); %H 7.96 (7.88). HPLC showed a single...when tethered or blended into polydimethylsiloxane . Attempts to model siloxanes28-30 are not new. Sun and Rigby31 were the first to develop a

Modification of carbon nanotube's dispersion using cetyltrimethyl ammonium bromide (CTAB) as cancer drug delivery

NASA Astrophysics Data System (ADS)

Wulan, Praswati PDK.; Wulandari, Hanifia; Ulwan, Sekar H.; Purwanto, Widodo W.; Mulia, Kamarza

2018-02-01

Cancer is a disease that causes many deaths globally. Cancer treatments have side effects that can danger the human body. Carbon nanotube (CNT) becomes drug (anti-cancer) delivery towards cancer cells that have been targeted. Yet, CNT tends to aggregate. It could be overcome by functionalization (modification) of CNT using Cetyltrimethyl Ammonium Bromide (CTAB). The variations we use were CNT-CTAB with a dose of CNT 100 mg and CTAB varied between 80, 90, 100, 110, and 120 mg. There were several stages of CNT modification process: dispersion, filtration, washing, and drying. The optimum condition obtained was on CNT-110 mg CTAB because it could be dispersed up to 70 hours better than pure CNT, Zeta Potential (ZP) ≥16 mV, and absorbance Uv-vis 1.05. Both the ZP value and the absorbance of Uv-vis showed the CNT dispersion modified to be better than the pure CNT. Furthermore, SEM-EDX did not produce structural damage to CNT modified surfaces, the percentage of the mass of Oxygen (O) elements as characteristic of increased hydrophilic properties, and Ni elements as toxic impurities become reduced. FTIR spectrum results showed the highest intensity occurred at CTAB CNT-110mg at 1221 m-1. This strong C-N vibration interaction suggests that CNTs CNT modification become readily dispersed in water.

Home - Southern IPM Center

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National Institute of Food and Agriculture Invests in Research on the Implications of Gene Editing Profiles PMSPs IPM Elements Crop Timelines United States Department of Agriculture - National Institute of Food and Agriculture Website managed by the Southern IPM Center. 1730 Varsity Drive, STE 110, NCSU

Home - Southern IPM Center

Science.gov Websites

of Food and Agriculture Invests in Research on the Implications of Gene Editing Technologies USDA IPM Elements Crop Timelines United States Department of Agriculture - National Institute of Food and Agriculture Website managed by the Southern IPM Center. 1730 Varsity Drive, STE 110, NCSU Centennial Campus

Atomically Visualizing Elemental Segregation-Induced Surface Alloying and Restructuring

DOE PAGES

Zou, Lianfeng; Li, Jonathan; Zakharov, Dmitri; ...

2017-12-01

Using in situ transmission electron microscopy that spatially and temporally resolves the evolution of the atomic structure in the surface and subsurface regions, we Find that the surface segregation of Au atoms in a Cu(Au) solid solution results in the nucleation and growth of a (2 × 1) missing-row reconstructed, half-unit-cell thick L1 2 Cu 3Au(110) surface alloy. Our in situ electron microscopy observations and atomistic simulations demonstrate that the (2 × 1) reconstruction of the Cu 3Au(110) surface alloy remains as a stable surface structure as a result of the favored Cu-Au diatom configuration.

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110

PubMed Central

2012-01-01

Background Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As the incidence of diabetes is rapidly rising worldwide, an ever increasing demand for diabetes drugs, such as acarbose, needs to be anticipated. Consequently, derived Actinoplanes strains with increased acarbose yields are being used in large scale industrial batch fermentation since 1990 and were continuously optimized by conventional mutagenesis and screening experiments. This strategy reached its limits and is generally superseded by modern genetic engineering approaches. As a prerequisite for targeted genetic modifications, the complete genome sequence of the organism has to be known. Results Here, we present the complete genome sequence of Actinoplanes sp. SE50/110 [GenBank:CP003170], the first publicly available genome of the genus Actinoplanes, comprising various producers of pharmaceutically and economically important secondary metabolites. The genome features a high mean G + C content of 71.32% and consists of one circular chromosome with a size of 9,239,851 bp hosting 8,270 predicted protein coding sequences. Phylogenetic analysis of the core genome revealed a rather distant relation to other sequenced species of the family Micromonosporaceae whereas Actinoplanes utahensis was found to be the closest species based on 16S rRNA gene sequence comparison. Besides the already published acarbose biosynthetic gene cluster sequence, several new non-ribosomal peptide synthetase-, polyketide synthase- and hybrid-clusters were identified on the Actinoplanes genome. Another key feature of the genome represents the discovery of a functional actinomycete integrative and conjugative element. Conclusions The complete genome sequence of Actinoplanes sp. SE50/110 marks an important step towards the rational genetic optimization of the acarbose production. In this regard, the identified actinomycete integrative and conjugative element could play a central role by providing the basis for the development of a genetic transformation system for Actinoplanes sp. SE50/110 and other Actinoplanes spp. Furthermore, the identified non-ribosomal peptide synthetase- and polyketide synthase-clusters potentially encode new antibiotics and/or other bioactive compounds, which might be of pharmacologic interest. PMID:22443545

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.

PubMed

Schwientek, Patrick; Szczepanowski, Rafael; Rückert, Christian; Kalinowski, Jörn; Klein, Andreas; Selber, Klaus; Wehmeier, Udo F; Stoye, Jens; Pühler, Alfred

2012-03-23

Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As the incidence of diabetes is rapidly rising worldwide, an ever increasing demand for diabetes drugs, such as acarbose, needs to be anticipated. Consequently, derived Actinoplanes strains with increased acarbose yields are being used in large scale industrial batch fermentation since 1990 and were continuously optimized by conventional mutagenesis and screening experiments. This strategy reached its limits and is generally superseded by modern genetic engineering approaches. As a prerequisite for targeted genetic modifications, the complete genome sequence of the organism has to be known. Here, we present the complete genome sequence of Actinoplanes sp. SE50/110 [GenBank:CP003170], the first publicly available genome of the genus Actinoplanes, comprising various producers of pharmaceutically and economically important secondary metabolites. The genome features a high mean G + C content of 71.32% and consists of one circular chromosome with a size of 9,239,851 bp hosting 8,270 predicted protein coding sequences. Phylogenetic analysis of the core genome revealed a rather distant relation to other sequenced species of the family Micromonosporaceae whereas Actinoplanes utahensis was found to be the closest species based on 16S rRNA gene sequence comparison. Besides the already published acarbose biosynthetic gene cluster sequence, several new non-ribosomal peptide synthetase-, polyketide synthase- and hybrid-clusters were identified on the Actinoplanes genome. Another key feature of the genome represents the discovery of a functional actinomycete integrative and conjugative element. The complete genome sequence of Actinoplanes sp. SE50/110 marks an important step towards the rational genetic optimization of the acarbose production. In this regard, the identified actinomycete integrative and conjugative element could play a central role by providing the basis for the development of a genetic transformation system for Actinoplanes sp. SE50/110 and other Actinoplanes spp. Furthermore, the identified non-ribosomal peptide synthetase- and polyketide synthase-clusters potentially encode new antibiotics and/or other bioactive compounds, which might be of pharmacologic interest.

Uncertainties in nuclear transition matrix elements for neutrinoless {beta}{beta} decay

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rath, P. K.

Uncertainties in nuclear transition matrix elements M{sup (0{nu})} and M{sub N}{sup (0{nu})} due to the exchange of light and heavy Majorana neutrinos, respectively have been estimated by calculating sets of twelve nuclear transition matrix elements for the neutrinoless {beta}{beta} decay of {sup 94,96}Zr, {sup 98,100}Mo, {sup 104}Ru, {sup 110}Pd, {sup 128,130}Te and {sup 150}Nd isotopes in the case of 0{sup +}{yields}0{sup +} transition by considering four different parameterizations of a Hamiltonian with pairing plus multipolar effective two-body interaction and three different parameterizations of Jastrow short range correlations. Exclusion of nuclear transition matrix elements calculated with the Miller-Spencer parametrization reduces themore » uncertainties by 10%-15%.« less

DNA Binding Behavior, Sensor Studies, Antimicrobial, Photocleavage and In vitro Cytotoxicity of Synthesized Ru(II) Complexes with Assorted Intercalating Polypyridyl Ligands.

PubMed

Mallepally, Rajender Reddy; Putta, Venkat Reddy; Chintakuntla, Nagamani; Vuradi, Ravi Kumar; Kotha, Laxma Reddy; Sirasani, Satyanarayana

2016-05-01

The four novel Ru(II) polypyridyl complexes of [Ru(Hdpa)2dmbip](2+) (1), [Ru(Hdpa)2NO2-dmbip](2+) (2), [Ru(Hdpa)2debip](2+) (3) and [Ru(Hdpa)2OH-debip](2+) (4) where Hdpa = 2,2'-bipyridylamine, dmbip = 2-(4-N,N-dimethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, debip = 2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, NO2-dmbip = NO2-2-(4-N,N-dimethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline, OH-debip = OH-2-(4-N,N-diethylbenzenamine)1H-imidazo[4,5-f][1,10]phenanthroline were synthesized and fully characterized using elemental analysis, Mass, NMR and FT-IR. The DNA binding behavior of all synthesized complexes were investigated by using electronic absorption spectra, emission spectra, cyclic light switch on and off, sensor studies, electrochemical method and viscosity titrations. Docking studies were performed with human DNA TOP1 by using LibDock. Furthermore explore antimicrobial activity, photocleavage and in vitro cytotoxicity assay of four Ru(II) complexes.

THE SOLAR BATTERY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shchekin, V.

1958-01-01

The maximum output capacity of silicon elements is 10 to 12 milliwatts/ cm/sup 2/ of photosensitive surface area. The efficiency of present-day silicon elements is 11 to 13% compared to 1% with other materials and the maximum efficiency of 22%. The Sputnik'' radio was powered from a solar battery of 5 v and fitted with a miniature TsNK-0.4 storage battery. It is calculated that to supply electricity for lighting a small flat or house at 110 v, 3 amp, a solar battery of 2 x 2 m would be sufficient. (W.D.M.)

Control of Polarization of Vertical-Cavity Surface - Lasers

NASA Astrophysics Data System (ADS)

Sun, Decai

1995-01-01

To date, most vertical-cavity surface-emitting lasers (VCSELs) have been fabricated from structures grown on GaAs (InP) substrates oriented in the (001) crystallographic axis. For the most part, these devices have exhibited linear, but random polarization states with no definite relationship to the in-plane crystallographic axes. The control of the polarization states of these devices is important for polarization-sensitive applications. Such applications include magneto-optic disk recording and coherent detection in advanced communication systems. In this thesis, a novel approach for controlling the polarization eigen-states of VCSELs is investigated. The approach utilizes anisotropic optical properties found in quantum wells (QW) oriented in directions other than the (001) to stabilize their polarization states. Specifically, the (110) direction is chosen for this work. An analysis of the in-plane optical matrix element connected with the gain coefficient of (In,Ga)As/GaAs QW structures grown on (110) GaAs substrates is conducted. It is found that the in-plane gain distribution is elliptically anisotropic--with a maximum directed along the (110) - (110) crystallographic axis. The design and growth of (In,Ga)As/GaAs QW VCSEL structures is studied in this work. The transition wavelengths of the (001) - and (110) -oriented (In,Ga)As/GaAs QW structures are calculated using a finite QW model. Distributed Bragg reflector mirrors consisting of GaAs/AlAs quarter wave layers are modeled using a characteristic matrix method. Threshold gain, internal and differential quantum efficiencies are analyzed. The growth of III-V compounds on (110) GaAs substrates by molecular beam epitaxy is investigated. High quality materials are successfully grown on the misoriented (110) GaAs substrates tilted by 6^circ toward the (111)B surface. (In,Ga)As/GaAs QW VCSEL structures are grown on (001) and (110) GaAs substrates. (In,Ga)As/GaAs QW VCSELs are fabricated from structures grown on the (001) and (110) surfaces. Experimental characterization shows that the devices fabricated from the (110) surface exhibit stable, well-defined polarization states at room temperature; this is in contrast to the random polarization characteristics observed from the VCSELs fabricated from the (001) surface. This stability is believed to be a consequence of the predicted anisotropic gain distribution on the (110) surface. Of the two orthogonal eigen-polarizations observed, the one with the higher optical intensity is found to be aligned along the (110) - (110) crystallographic axis; this is in agreement with theoretical predictions.

Heterogeneous Reduction Pathways for Hg(II) Species on Dry Aerosols: A First-Principles Computational Study

DOE PAGES

Tacey, Sean A.; Xu, Lang; Mavrikakis, Manos; ...

2016-03-25

Here, the atmospheric lifetime of mercury is greatly impacted by redox chemistry resulting from the high deposition rate of reactive mercury (Hg(II)) compared to elemental mercury (Hg 0). Recent laboratory and field studies have observed the reduction of Hg(II) but the chemical mechanism for this reaction has not been identified. Recent laboratory studies have shown that the reduction reaction is heterogeneous and can occur on iron and sodium chloride aerosol surfaces. This study explores the use of density functional theory calculations to discern the reduction pathways of HgCl 2, HgBr 2, Hg(NO 3) 2, and HgSO 4 on clean Fe(110),more » NaCl(100), and NaCl(111) Na surfaces. In doing so, potential energy surfaces have been prepared for the various reduction pathways, indicating that the reduction pathway leading to the production of gas-phase elemental mercury is highly favorable on Fe(110) and NaCl(111) Na. Moreover, the Fe(110) surface requires an external energy source of approximately 0.5 eV to desorb the reduced mercury, whereas the NaCl(111) Na surface requires no energy input. The results indicate that a number of mercury species can be reduced on metallic iron and sodium chloride surfaces, which are known aerosol components, and that a photochemical reaction involving the aerosol surface is likely needed for the reaction to be catalytic.« less

77 FR 47573 - Approval and Promulgation of Implementation Plans; Mississippi; 110(a)(2)(E)(ii) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... Mississippi Department of Environmental Quality (MDEQ), on July 13, 2012, for parallel processing. This... of Contents I. What is parallel processing? II. Background III. What elements are required under... Executive Order Reviews I. What is parallel processing? Consistent with EPA regulations found at 40 CFR Part...

77 FR 57029 - Approval and Promulgation of State Implementation Plan Revisions; Infrastructure Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-17

... either electronically through www.regulations.gov or in hard copy at the Air Program, Environmental... 4 p.m., excluding Federal holidays. FOR FURTHER INFORMATION CONTACT: Kathy Ayala, Air Program, U.S... 1997 ozone NAAQS, states typically have met the basic program elements required in section 110(a)(2...

76 FR 17585 - Approval and Promulgation of Implementation Plans; State of Missouri

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-30

... 1997 revisions to the National Ambient Air Quality Standards (NAAQS) for ozone. Section 110(a)(1... modeling to assure attainment and maintenance of the applicable standards. By statute, SIPs meeting the... ozone and PM 2.5 NAAQS.\\1\\ EPA will address these elements below under the following headings: (A...

75 FR 7525 - Application for a License To Export High-Enriched Uranium

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-19

... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the..., February 2, Uranium (93.35%). uranium (87.3 elements in 2010, February 2, 2010, kilograms U-235). France...

A Study of the Acoustic-Optic Effect in Nematics.

DTIC Science & Technology

1980-12-31

PERFORMING ORGANIZATION NJAME AND ADDRESS R (RORAM ELEMENT PROJECT, TASK 00 Department of Physics and Astronomy University of Hawaii 110 𔃻’ Honolulu...optic-! effect was attributed to soic sort of physical movement within the liquid crysta. In 1970 lesi;or and ’,wyer 7 otited a 10 MHz, ul trusoni c

Numerical study of slip system activity and crystal lattice rotation under wedge nanoindents in tungsten single crystals

NASA Astrophysics Data System (ADS)

Volz, T.; Schwaiger, R.; Wang, J.; Weygand, S. M.

2018-05-01

Tungsten is a promising material for plasma facing components in future nuclear fusion reactors. In the present work, we numerically investigate the deformation behavior of unirradiated tungsten (a body-centered cubic (bcc) single crystal) underneath nanoindents. A finite element (FE) model is presented to simulate wedge indentation. Crystal plasticity finite element (CPFE) simulations were performed for face-centered and body-centered single crystals accounting for the slip system family {110} <111> in the bcc crystal system and the {111} <110> slip family in the fcc system. The 90° wedge indenter was aligned parallel to the [1 ¯01 ]-direction and indented the crystal in the [0 1 ¯0 ]-direction up to a maximum indentation depth of 2 µm. In both, the fcc and bcc single crystals, the activity of slip systems was investigated and compared. Good agreement with the results from former investigations on fcc single crystals was observed. Furthermore, the in-plane lattice rotation in the material underneath an indent was determined and compared for the fcc and bcc single crystals.

Preferred growth orientation and microsegregation behaviors of eutectic in a nickel-based single-crystal superalloy

PubMed Central

Ma, Dexin; Bührig-Polaczek, Andreas

2015-01-01

A nickel-based single-crystal superalloy was employed to investigate the preferred growth orientation behavior of the (γ + γ′) eutectic and the effect of these orientations on the segregation behavior. A novel solidification model for the eutectic island was proposed. At the beginning of the eutectic island’s crystallization, the core directly formed from the liquid by the eutectic reaction, and then preferably grew along [100] direction. The crystallization of the eutectic along [110] always lagged behind that in [100] direction. The eutectic growth in [100] direction terminated on impinging the edge of the dendrites or another eutectic island. The end of the eutectic island’s solidification terminates due to the encroachment of the eutectic liquid/solid interface at the dendrites or another eutectic island in [110] direction. The distribution of the alloying elements depended on the crystalline axis. The degree of the alloying elements’ segregation was lower along [100] than [110] direction with increasing distance from the eutectic island’s center. PMID:27877773

Hydrogen-based electrochemical energy storage

DOEpatents

Simpson, Lin Jay

2013-08-06

An energy storage device (100) providing high storage densities via hydrogen storage. The device (100) includes a counter electrode (110), a storage electrode (130), and an ion conducting membrane (120) positioned between the counter electrode (110) and the storage electrode (130). The counter electrode (110) is formed of one or more materials with an affinity for hydrogen and includes an exchange matrix for elements/materials selected from the non-noble materials that have an affinity for hydrogen. The storage electrode (130) is loaded with hydrogen such as atomic or mono-hydrogen that is adsorbed by a hydrogen storage material such that the hydrogen (132, 134) may be stored with low chemical bonding. The hydrogen storage material is typically formed of a lightweight material such as carbon or boron with a network of passage-ways or intercalants for storing and conducting mono-hydrogen, protons, or the like. The hydrogen storage material may store at least ten percent by weight hydrogen (132, 134) at ambient temperature and pressure.

Flexure-based nanomagnetic actuators

NASA Astrophysics Data System (ADS)

Vasquez, Daniel James

Nanometer-scale actuators powered through applied-magnetic fields have been designed, fabricated, and tested. These actuators consist of one or more ferromagnetic elements attached to a mechanical flexure. Two types of flexures were studied including a cantilever beam that is fixed on one end, and free on the other. The free end of the cantilever is attached to a, ferromagnetic element allowing a bending torque to be applied by a magnetic field. The second type of actuator design uses a set of torsion beams that are each anchored on one end, and attached to the magnetic element on the other end. The torsion beams are designed such that the application of a magnetic field will result in a twist along the long axis of the beam with little to no bending. The smallest fabricated and tested device is a cantilever-based ferromagnetic actuator that consists of a single 1.5-mum-long, 338-nm-wide, and 50-nm-thick nickel element, and a 2.2-mum-long, 110-nm-wide, and 30-nm-thick gold cantilever beam. A deflection of over 17° was measured for this actuator, while a similar one with a 10.1-mum long cantilever beam experienced measured deflections up to 57°. Torsion-based ferromagnetic actuators have been fabricated and tested with 110-nm-wide, and 50-rim-thick magnetic elements. Such magnetic elements contain only a single saturated magnetic domain. The ultimate scalability of ferromagnetic actuation is limited by the ability of thermal noise to affect the temporal stability of a nanometer-scale magnet. Theory to describe thermal noise and ultimate scalability of the ferromagnetic actuators has been developed. The size of the ferromagnetic actuators studied in this manuscript are smaller than most plant and animal cells. This enables the possibility of such actuators to manipulate a, living cell on an intracellular level. Other potential applications of such small actuators include MHz, to GHz frequency resonators, and tunable optical filters.

Reading Instruction for Fourth-Grade Struggling Readers and the Relation to Student Outcomes

ERIC Educational Resources Information Center

Kent, Shawn C.; Wanzek, Jeanne; Al Otaiba, Stephanie

2017-01-01

The present study examined the amount, type, and quality of Tier 1 and supplemental reading instruction provided to 4th-grade struggling readers and whether specific elements of instruction predicted growth in reading skills. In all, 110 students identified as having reading difficulty who were receiving school-based reading instruction in 22…

Power Spectra of Geomagnetic Fluctuations between 0.02 and 20 Hz

DTIC Science & Technology

1981-12-01

BACKGROUND ----------------------------------------- 10 A. MAIN MAGNETIC FIELD ---------------------------- 10 B. ELEMENTS OF THE FIELD...Chew’s Ridge Sensor Orientation ------------------- 33 12. East-West Magnetic Field Fluctuations (.01-S Hz) 8/21/81, 1345 Hrs...36 13. East-West Magnetic Field Fluctuations (.1-10 H:) 8/21/81, 134S Hrs. -------------------------------- 37 14. East-West Magnetic Field

10 CFR Appendix O to Part 110 - Illustrative List of Fuel Element Fabrication Plant Equipment and Components Under NRC's Export...

Code of Federal Regulations, 2011 CFR

2011-01-01

... performance and safety during reactor operation. Also, in all cases precise control of processes, procedures... performance. (a) Items that are considered especially designed or prepared for the fabrication of fuel... pellets; (2) Automatic welding machines especially designed or prepared for welding end caps onto the fuel...

40 CFR 147.2050 - State-administered program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 24, 1984. This program consists of the following elements, as submitted to EPA in the State's program... the Director of the Federal Register effective July 24, 1984. (1) Pollution Control Act, S.C. Code Ann. Sections 48-1-10, 48-1-90, 48-1-100, 48-1-110 (Law. Co-op. 1976 and Supp. 1983). (2) South Carolina...

Environmental mobility of (110m)Ag: lessons learnt from Fukushima accident (Japan) and potential use for tracking the dispersion of contamination within coastal catchments.

PubMed

Lepage, Hugo; Evrard, Olivier; Onda, Yuichi; Patin, Jeremy; Chartin, Caroline; Lefèvre, Irène; Bonté, Philippe; Ayrault, Sophie

2014-04-01

Silver-110 metastable ((110m)Ag) has been far less investigated than other anthropogenic radionuclides, although it has the potential to accumulate in plants and animal tissues. It is continuously produced by nuclear power plants in normal conditions, but emitted in much larger quantities in accidental conditions facilitating its detection, which allows the investigation of its behaviour in the environment. We analysed (110m)Ag in soil and river drape sediment (i.e., mud drapes deposited on channel-bed sand) collected within coastal catchments contaminated in Fukushima Prefecture (Japan) after the Fukushima Dai-ichi Nuclear Power Plant accident that occurred on 11 March 2011. Several field experiments were conducted to document radiosilver behaviour in the terrestrial environment, with a systematic comparison to the more documented radiocesium behaviour. Results show a similar and low mobility for both elements in soils and a strong affinity with the clay fraction. Measurements conducted on sediment sequences accumulated in reservoirs tend to confirm a comparable deposition of those radionuclides even after their redistribution due to erosion and deposition processes. Therefore, as the (110m)Ag:(137)Cs initial activity ratio varied in soils across the area, we justified the relevance of using this tool to track the dispersion of contaminated sediment from the main inland radioactive pollution plume generated by FDNPP accident. Copyright © 2014 Elsevier Ltd. All rights reserved.

Performances of Different Fragment Sizes for Reduced Representation Bisulfite Sequencing in Pigs.

PubMed

Yuan, Xiao-Long; Zhang, Zhe; Pan, Rong-Yang; Gao, Ning; Deng, Xi; Li, Bin; Zhang, Hao; Sangild, Per Torp; Li, Jia-Qi

2017-01-01

Reduced representation bisulfite sequencing (RRBS) has been widely used to profile genome-scale DNA methylation in mammalian genomes. However, the applications and technical performances of RRBS with different fragment sizes have not been systematically reported in pigs, which serve as one of the important biomedical models for humans. The aims of this study were to evaluate capacities of RRBS libraries with different fragment sizes to characterize the porcine genome. We found that the Msp I-digested segments between 40 and 220 bp harbored a high distribution peak at 74 bp, which were highly overlapped with the repetitive elements and might reduce the unique mapping alignment. The RRBS library of 110-220 bp fragment size had the highest unique mapping alignment and the lowest multiple alignment. The cost-effectiveness of the 40-110 bp, 110-220 bp and 40-220 bp fragment sizes might decrease when the dataset size was more than 70, 50 and 110 million reads for these three fragment sizes, respectively. Given a 50-million dataset size, the average sequencing depth of the detected CpG sites in the 110-220 bp fragment size appeared to be deeper than in the 40-110 bp and 40-220 bp fragment sizes, and these detected CpG sties differently located in gene- and CpG island-related regions. In this study, our results demonstrated that selections of fragment sizes could affect the numbers and sequencing depth of detected CpG sites as well as the cost-efficiency. No single solution of RRBS is optimal in all circumstances for investigating genome-scale DNA methylation. This work provides the useful knowledge on designing and executing RRBS for investigating the genome-wide DNA methylation in tissues from pigs.

PROTON MICROPROBE ANALYSIS OF TRACE-ELEMENT VARIATIONS IN VITRINITES IN THE SAME AND DIFFERENT COAL BEDS.

USGS Publications Warehouse

Minkin, J.A.; Chao, E.C.T.; Blank, Herma; Dulong, F.T.

1987-01-01

The PIXE (proton-induced X-ray emission) microprobe can be used for nondestructive, in-situ analyses of areas as small as those analyzed by the electron microprobe, and has a sensitivity of detection as much as two orders of magnitude better than the electron microprobe. Preliminary studies demonstrated that PIXE provides a capability for quantitative determination of elemental concentrations in individual coal maceral grains with a detection limit of 1-10 ppm for most elements analyzed. Encouraged by the earlier results, we carried out the analyses reported below to examine trace element variations laterally (over a km range) as well as vertically (cm to m) in the I and J coal beds in the Upper Cretaceous Ferron Sandstone Member of the Mancos Shale in central Utah, and to compare the data with the data from two samples of eastern coals of Pennsylvanian age.

The production of transuranium elements by the r-process nucleosynthesis

NASA Astrophysics Data System (ADS)

Goriely, S.; Martínez Pinedo, G.

2015-12-01

The production of super-heavy transuranium elements by stellar nucleosynthesis processes remains an open question. The most promising process that could potentially give rise to the formation of such elements is the so-called rapid neutron-capture process, or r-process, known to be at the origin of approximately half of the A > 60 stable nuclei observed in nature. However, despite important efforts, the astrophysical site of the r-process remains unidentified. Here, we study the r-process nucleosynthesis in material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars. Neutron star mergers could potentially be the dominant r-process site in the Galaxy, but also due to the extreme neutron richness found in such environment, could potentially synthesise super-heavy elements. R-process nucleosynthesis during the decompression is known to be largely insensitive to the detailed astrophysical conditions because of efficient fission recycling, producing a composition that closely follows the solar r-abundance distribution for nuclei with mass numbers A > 140. During the neutron irradiation, nuclei up to charge numbers Z ≃ 110 and mass number A ≃ 340 are produced, with a major peak production at the N = 184 shell closure, i.e. around A ≃ 280. Super-heavy nuclei with Z > 110 can hardly be produced due to the efficient fission taking place along those isotopic chains. Long-lived transuranium nuclei are inevitably produced by the r-process. The predictions concerning the production of transuranium nuclei remain however very sensitive to the predictions of fission barrier heights for such super-heavy nuclei. More nuclear predictions within different microscopic approaches are needed.

Synthesis of Textures Using Simultaneous Autoregressive Models.

DTIC Science & Technology

1981-07-01

CHELLAPPA AFOSR-77-3271 UNCLASSIFIED TR- 1082 AFOSR-TR-81-0795 NL 110~2.8 .113:’I0 111.02. 1111I25 II.4~* 1.6 MICROCOPY R[ SOLUTION ILS1 CHARI ,.TR- 81...NUMBER TR- 1082 . 7. AUTHOR(*) S. CONTRACT OR GRANT NUMBER(&) R. Chella-)pa AFOSR-77-3271 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT

77 FR 72287 - Approval and Promulgation of Implementation Plans; Florida; 110(a)(2)(D)(i)(II) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

....gov Web site is an ``anonymous access'' system, which means EPA will not know your identity or contact... inventories, monitoring, and modeling to assure attainment and maintenance of the NAAQS. States were required... infrastructure elements for the 1997 PM 2.5 NAAQS by October 3, 2008. On July 6, 2011, WildEarth Guardians and...

77 FR 34306 - Approval and Promulgation of Implementation Plans; Tennessee; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

...'' system, which means EPA will not know your identity or contact information unless you provide it in the..., including emissions inventories, monitoring, and modeling to assure attainment and maintenance of the NAAQS... elements for the 1997 PM 2.5 NAAQS by October 3, 2008. On July 6, 2011, WildEarth Guardians and Sierra Club...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ingham, J.G.

The IDENT 1578 container, which is a 110-in. long 5.5-in. OD tube, is designed for shipping FFTF fuel elements in T-3 casks between HEDL, HFEF, and other laboratories. The thermal analysis was conducted to evaluate whether or not the container satisfies its thermal design criteria (handle a decay heat load of 600 watts, max fuel pin cladding temperature not exceeding 800/sup 0/F).

77 FR 62191 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Infrastructure and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... such shorter period as EPA may prescribe. Section 110(a)(2) lists the specific infrastructure elements... Act (Act) requires that each state adopt and submit to EPA, within 3 years (or such shorter time... Tailoring Rule because the State does not have the authority to apply the meaning of the term ``subject to...

40 CFR 52.1019 - Identification of plan-conditional approval.

Code of Federal Regulations, 2013 CFR

2013-07-01

...), (C) only as it relates to the PSD program, (D)(i)(II) only as it relates to the PSD program, (D)(ii), (E)(ii), and (J) only as it relates to the PSD program. This conditional approval is contingent upon... conditionally approved for CAA elements 110(a)(2)(A), (C) only as it relates to the PSD program, (D)(i)(II) only...

40 CFR 52.1019 - Identification of plan-conditional approval.

Code of Federal Regulations, 2014 CFR

2014-07-01

...), (C) only as it relates to the PSD program, (D)(i)(II) only as it relates to the PSD program, (D)(ii), (E)(ii), and (J) only as it relates to the PSD program. This conditional approval is contingent upon... conditionally approved for CAA elements 110(a)(2)(A), (C) only as it relates to the PSD program, (D)(i)(II) only...

Debris Cloud Material Characterization for Hypervelocity Impacts of Single- and Multi-Material Projectiles on Thin Target Plates

DTIC Science & Technology

1994-05-01

1979. 110 42. Williams, A.E., and Saravane, I., Debris Chlaraiatiaon SUt&y NRL Letter Rleport 4680-196,1990. 43. Weanzel, A.B., and Dean , J.K., Behind...Commerce, National Bureau of Standards, Washington, D.C., 1971. 52. Stull , D.X, and Sinke, G.C., *Thermodynamic Properties of the Elements", in Advances in

Measuring the content of 17 elements in the flesh of Prunus cerasifera and its cultivars by ICP-MS.

PubMed

Shen, Jing; Xue, Hai-Yan; Li, Gai-Ru; Lu, Yi; Yao, Jun

2014-09-01

The present study compared the contents of inorganic elements in the pulp of purple, red, and yellow Prunus cerasifera with its cultivars. A method was established for the analysis of 17 kinds of trace elements (K, Ca, Mg, Na, Fe, Mn, Cu, Zn, Be, Li, Se, Sr, Cr, Pb, Cd, As and Hg) in the flesh of Prunus cerasifera by microwave digestion-ICP-MS. The detection method is simple and quick, yet shoes high precision and high sensitivity. The recovery rate of 17 elements ranged, from 93.5% to 110.4%. The analysis results showed that the contents of 17 elements in the flesh of purple, red, and yellow Prunus cerasifera and its cultivars are similar, containing extremely rich K elements (as high as 1 per thousand) and higher contents of Ca, Mg, Na, Fe and Mn. The contents of Cu, Zn, Li, Se, Sr and Cr are also present. The contents of Pb, Cd, As, Hg and other harmful element are either very low or not detectable. The experimental results for the study of trace elements in pulp of Prunus cerasifera and its cultivars provide empirical data for. future research in this area.

In-vivo measurement of relationship between applied current amplitude and current density magnitude from 10 mA to 110 mA.

PubMed

DeMonte, Tim P; Wang, Dinghui; Ma, Weijing; Gao, Jia-Hong; Joy, Michael L G

2009-01-01

Current density imaging (CDI) is a magnetic resonance imaging (MRI) technique used to quantitatively measure current density vectors throughout the volume of an object/subject placed in the MRI system. Electrical current pulses are applied externally to the object/subject and are synchronized with the MRI sequence. In this work, CDI is used to measure average current density magnitude in the torso region of an in-vivo piglet for applied current pulse amplitudes ranging from 10 mA to 110 mA. The relationship between applied current amplitude and current density magnitude is linear in simple electronic elements such as wires and resistors; however, this relationship may not be linear in living tissue. An understanding of this relationship is useful for research in defibrillation, human electro-muscular incapacitation (e.g. TASER(R)) and other bioelectric stimulation devices. This work will show that the current amplitude to current density magnitude relationship is slightly nonlinear in living tissue in the range of 10 mA to 110 mA.

76 FR 41088 - Approval and Promulgation of Implementation Plans; Kentucky; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 13, 2007, submission by the Commonwealth of Kentucky, through the Kentucky Division of Air Quality (KDAQ) as demonstrating that the Commonwealth meets the state implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8- hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. Kentucky certified that the Kentucky SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in Kentucky (hereafter referred to as ``infrastructure submission''). Kentucky's infrastructure submission, provided to EPA on December 13, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is responding to adverse comments received on EPA's March 17, 2011, proposed approval of Kentucky's December 13, 2007, infrastructure submission.

76 FR 41100 - Approval and Promulgation of Implementation Plans; Alabama; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 10, 2007, submission by the State of Alabama, through the Alabama Department of Environmental Management (ADEM) as demonstrating that the State meets the state implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8-hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. Alabama certified that the Alabama SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in Alabama (hereafter referred to as ``infrastructure submission''). Alabama's infrastructure submission, provided to EPA on December 10, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is responding to adverse comments received on EPA's March 17, 2011, proposed approval of Alabama's December 10, 2007, infrastructure submission.

76 FR 41123 - Approval and Promulgation of Implementation Plans; Mississippi; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 7, 2007, submission by the State of Mississippi, through the Mississippi Department of Environmental Quality (MDEQ) as demonstrating that the State meets the implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8- hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. Mississippi certified that the Mississippi SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in Mississippi (hereafter referred to as ``infrastructure submission''). Mississippi's infrastructure submission, provided to EPA on December 7, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is responding to adverse comments received on EPA's March 17, 2011, proposed approval of Mississippi's December 7, 2007, infrastructure submission.

Synthesis, spectral, thermal and biological studies of mixed ligand complexes with newly prepared Schiff base and 1,10-phenanthroline ligands

NASA Astrophysics Data System (ADS)

Abd El-Halim, Hanan F.; Mohamed, Gehad G.; Khalil, Eman A. M.

2017-10-01

A series of mixed ligand complexes were prepared from the Schiff base (L1) as a primary ligand, prepared by condensation of oxamide and furan-2-carbaldehyde, and 1,10-phenanthroline (1,10-phen) as a secondary ligand. The Schiff base ligand and its mixed ligand chelates were characterized based on elemental analysis, IR, 1H NMR, thermal analysis, UV-Visible, mass, molar conductance, magnetic moment. X-ray diffraction, solid reflectance and ESR also have been studied. The mixed ligand complexes were found to have the formulae of [M(L1) (1,10-phen)]Clm.nH2O (M = Cr(III) and Fe(III) (m = 3) (n = 0); M = Mn(II), Cu(II) and Cd(II) (m = 2) (n = 0); and M = Co(II) (m = 2) (n = 1), Ni(II) (m = 2) (n = 2) and Zn(II) (m = 2) (n = 3)) and that the geometrical structure of the complexes were octahedral. The parameters of thermodynamic using Coats-Redfern and Horowitz-Metzger equations were calculated. The synthesized Schiff base ligand, 1,10-phenanthroline ligand and Their mixed ligand complexes were also investigated for their antibacterial and antifungal activity against bacterial species (Gram-Ve bacteria: Pseudomonas aeruginosa and Escherichia coli) and (Gram + Ve bacteria: Bacillus subtilis and Streptococcus pneumonia) and fungi (Aspergillus fumigates and Candida albicans). The anticancer activity of the new compounds had been tested against breast (MFC7) and colon (HCT-116) cell lines. The results showed high activity for the synthesized compounds.

Synthesis reactions and radioactive properties of transactinoid elements

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.

1994-10-01

It is well known that the heaviest elements of the periodic table have been synthesized in the cold fusion of magic nuclei of Pb with Z less than 26 ions. Because of dynamic limitations for fusion under strong Coulomb interaction of nuclei, the cross-sections of cold fusion reactions diminish exponentially with growing compound nucleus atomic number. For element Z = 110 produced in the reaction Pb-208(Ni-62,n)(sub 271)110, the expected cross-section is 10(exp -36) sq cm. In still more asymmetric reactions, when isotopes of actinoid elements irradiated with relatively light ions (Z less than or equal 12) are used as the target material, the compound nuclei possess an excitation energy of approx. 50 MeV. At this energy the nuclear shell effects are strongly suppressed and, as a result, in the case of hot compound nuclei of transactinoid elements the fission barrier is practically absent. The transition of these nuclei into the ground state depends strongly on the dynamic properties of the system with respect to the fission degree of freedom. Experimental studies were going on in two directions: (1) determination of the fission time by measuring the prefission neutrons (of Cf-Fm nuclei) in a wide interval of excitation energies; (2) direct synthesis of known nuclides with Z = 102-105 in reactions with ions of Ne-22, Mg-26, Al-27 and P-31 when final nuclei are produced in the ground state after the evaporation of five or six neutrons from the excited compound nuclei (E(sub x) = 50-60 MeV). The dependence of the reaction cross-section (HI, 5-6n) on the atomic number of the compound nucleus in different target-ion combinations points to the possibility of synthesizing new elements in hot fusion reactions. The advantage of these reactions arises from the use of neutron-rich nuclei like Cm-248 and Cf-249 which allows us to synthesize nuclei close to the deformed shell N = 162, for which a considerable growth of stability against spontaneous fission is predicted. Experimental set-ups and methods of detecting rare events of formation and decay of transactinide nuclei are described.

77 FR 34898 - Approval and Promulgation of Implementation Plans; Mississippi; 110(a)(1) and (2) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

...'' system, which means EPA will not know your identity or contact information unless you provide it in the... modeling to assure attainment and maintenance of the NAAQS. States were required to submit such SIPs to EPA... infrastructure elements for the 1997 PM 2.5 NAAQS by October 3, 2008. On July 6, 2011, WildEarth Guardians and...

Eastern Europe: Status of U.S. Assistance Efforts

DTIC Science & Technology

1991-02-26

110 United States e= General Accounting OfficeWashington, D.C. 20548 Accesion For National Security and NTIS CRA&M International Affairs Division DTIC...the international donor community or the East European governments, (2) Hungarian government officials have not clearly identified the type and...through the International Red Cross and $250,000 for medical supplies. The five principal SEED program elements were: " Structural adjustment assistance

40 CFR 52.1519 - Identification of plan-conditional approval.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Air Act (CAA) elements 110(a)(2)(A), (C) only as it relates to the PSD program, (D)(i)(II) only as it relates to the PSD program, (E)(ii), and (J) only as it relates to the PSD program. This conditional... relates to the PSD program, (D)(i)(II) only as it relates to the PSD program, (E)(ii), and (J) only as it...

40 CFR 52.1519 - Identification of plan-conditional approval.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Air Act (CAA) elements 110(a)(2)(A), (C) only as it relates to the PSD program, (D)(i)(II) only as it relates to the PSD program, (E)(ii), and (J) only as it relates to the PSD program. This conditional... relates to the PSD program, (D)(i)(II) only as it relates to the PSD program, (E)(ii), and (J) only as it...

Grisms Developed for FOCAS

NASA Astrophysics Data System (ADS)

Ebizuka, Noboru; Kawabata, Koji S.; Oka, Keiko; Yamada, Akiko; Kashiwagi, Masako; Kodate, Kashiko; Hattori, Takashi; Kashikawa, Nobunari; Iye, Masanori

2011-03-01

Faint Object Camera and Spectrograph (FOCAS) is a versatile common-use optical instrument for the 8.2 m Subaru Telescope, offering imaging and spectroscopic observations. FOCAS employs grisms with resolving powers ranging from 280 to 8200 as dispersive optical elements. A grism is a direct-vision grating composed of a transmission grating and prism(s). FOCAS has five grisms with replica surface-relief gratings including an echelle-type grism, and eight grisms with volume-phase holographic (VPH) gratings. The size of these grisms is 110 mm × 106 mm in aperture with a maximum thickness of 110 mm. We employ not only the dichromated gelatin, but also the hologram resin as a recording material for VPH gratings. We discuss the performance of these FOCAS grisms measured in the laboratory, and verify it by test observations, and show examples of astronomical spectroscopic observations.

Effects of washing on mineral composition of leaf samples of Lycium andersonii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallace, A.; Romney, E.M.; Hunter, R.B.

1982-07-01

Leaves of Lycium andersonii A. Gray from 20 different shrubs from the northern Mojave Desert were collected. Half of each sample was washed in 1/10 N HCl followed with deionized water before analysis in triplicate by optical emission spectrometry, and the other half was analyzed unwashed. Washed samples contained 12, 35, 33, 40, 55, 47, 57, 8, 8, 9, and 20 percent, respectivey, less calcium, zinc, copper, iron, aluminum, silicon, titanium, strontium, barium, lithium, and lead than did unwashed leaves. The losses probably exceed contamination for some elements, because the results differed in some respects from those obtained for citrus.more » Statisticaly significant differences were not obtained for other elements analyzed. Even though 40 to 57 percent of the iron, aluminum, silicon, and titanium was washed from the leaves, cluster analyses grouped the four elements into a common cluster whether or not the leaves had been washed. Washing resulted in a lower coefficient of variation for some of the elements compared with unwashed leaves.« less

Positron states and annihilation characteristics of surface-trapped positrons at the oxidized Cu(110) surface

NASA Astrophysics Data System (ADS)

Fazleev, N. G.; Olenga, Antoine; Weiss, A. H.

2013-03-01

The process by which oxide layers are formed on metal surfaces is still not well understood. In this work we present the results of theoretical studies of positron states and annihilation characteristics of surface-trapped positrons at the oxidized Cu(110) surface. An ab-initio investigation of stability and associated electronic properties of different adsorption phases of oxygen on Cu(110) has been performed on the basis of density functional theory and using DMOl3 code. The changes in the positron work function and the surface dipole moment when oxygen atoms occupy on-surface and sub-surface sites have been attributed to charge redistribution within the first two layers, buckling effects within each layer and interlayer expansion. The computed positron binding energy, positron surface state wave function, and annihilation probabilities of surface trapped positrons with relevant core electrons demonstrate their sensitivity to oxygen coverage, elemental content, atomic structure of the topmost layers of surfaces, and charge transfer effects. Theoretical results are compared with experimental data obtained from studies of oxidized transition metal surfaces using positron annihilation induced Auger electron spectroscopy. This work was supported in part by the National Science Foundation Grant DMR-0907679.

Luminescent hybrid lanthanide sulfates and lanthanide sulfonate-carboxylates with 1,10-phenanthroline involving in-situ oxidation of 2-mercaptonbenzoic acid

NASA Astrophysics Data System (ADS)

Zhong, Jie-Cen; Wan, Fang; Sun, Yan-Qiong; Chen, Yi-Ping

2015-01-01

A series of lanthanide sulfates and lanthanide sulfonate-carboxylates, [Ln2(phen)2(SO4)3(H2O)2]n (I:Ln=Nd(1a), Sm(1b), Eu(1c), phen=1,10-phenanthroline) and [Ln(phen)(2-SBA)(BZA)]n (II: Ln=Sm(2a), Eu(2b), Dy(2c), 2-SBA=2-sulfobenzoate, BZA=benzoate) have been hydrothermally synthesized from lanthanide oxide, 2-mercaptonbenzoic acid with phen as auxiliary ligand and characterized by single-crystal X-ray diffraction, elemental analyses, IR spectra, TG analyses and luminescence spectroscopy. Interestingly, SO4 2 - anions in I came from the in situ deep oxidation of thiol groups of 2-mercaptonbenzoic acid while 2-sulfobenzoate and benzoate ligands in II from the middle oxidation and desulfuration reactions of 2-mercaptonbenzoic acid. Compounds I are organic-inorganic hybrid lanthanide sulfates, which have rare one-dimensional column-like structures. Complexes II are binuclear lanthanide sulfonate-carboxylates with 2-sulfobenzoate and benzoate as bridges and 1,10-phenanthroline as terminal. Photoluminescence studies reveal that complexes I and II exhibit strong lanthanide characteristic emission bands in the solid state at room temperature.

76 FR 41111 - Approval and Promulgation of Implementation Plans; South Carolina; 110(a)(1) and (2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...EPA is taking final action to approve the December 13, 2007, submission submitted by the State of South Carolina, through the South Carolina Department of Health and Environmental Control (SC DHEC) as demonstrating that the State meets the state implementation plan (SIP) requirements of sections 110(a)(1) and (2) of the Clean Air Act (CAA or the Act) for the 1997 8-hour ozone national ambient air quality standards (NAAQS). Section 110(a) of the CAA requires that each state adopt and submit a SIP for the implementation, maintenance, and enforcement of each NAAQS promulgated by the EPA, which is commonly referred to as an ``infrastructure'' SIP. South Carolina certified that the South Carolina SIP contains provisions that ensure the 1997 8-hour ozone NAAQS is implemented, enforced, and maintained in South Carolina (hereafter referred to as ``infrastructure submission''). South Carolina's infrastructure submission, provided to EPA on December 13, 2007, addressed all the required infrastructure elements for the 1997 8-hour ozone NAAQS. Additionally, EPA is correcting an inadvertent error and responding to adverse comments received on EPA's March 17, 2011, proposed approval of South Carolina's December 13, 2007, infrastructure submission.

[Migration of eight harmful elements from household products made with synthetic resin that infants may swallow by mistake].

PubMed

Isama, Kazuo; Kawakami, Tsuyoshi; Nishimura, Tetsuji

2011-01-01

Harmful elements are used as stabilizers and colorants in synthetic resin products. Accidental ingestion of harmful elements from such synthetic resins by infants is a dangerous health hazard. The Japanese Food Sanitation Law and the International Standard ISO 8124-3 "Safety of toys-Part 3: Migration of certain elements" control the levels of migrated harmful elements, such as lead or cadmium, from infants toys. However, the levels of migrated harmful elements from household products that are not infants toys are not controlled, since they are not covered by the law or standard. Therefore, we investigated the level of eight harmful elements (antimony, arsenic, barium, cadmium, chromium, lead, mercury and selenium) migrated from household products made of synthetic resin that infants may swallow by mistake. The extraction test of ISO 8124-3: 2010 was executed in 135 products (total 150 specimens), and the concentration of these elements was measured by inductively coupled plasma mass spectroscopy (ICP-MS). As a result, 1810 mg/kg and 1660 mg/kg of lead, exceeding the maximum acceptable level of the ISO standard, migrated from two products. In addition, lead and/or chromium at levels more than 1/10 of the maximum acceptable levels of the ISO standard migrated from four products. Household products that infants may swallow by mistake should ideally not release harmful elements such as lead and chromium.

Tensile and high cycle fatigue behaviors of high-Mn steels at 298 and 110 K

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seo, Wongyu; Jeong, Daeho; Sung, Hyokyung

Tensile and high cycle fatigue behaviors of high-Mn austenitic steels, including 25Mn, 25Mn0.2Al, 25Mn0.5Cu, 24Mn4Cr, 22Mn3Cr and 16Mn2Al specimens, were investigated at 298 and 110 K. Depending on the alloying elements, tensile ductility of high-Mn steels either increased or decreased with decreasing temperature from 298 to 110 K. Reasonable correlation between the tendency for martensitic tranformation, the critical twinning stress and the percent change in tensile elongation suggested that tensile deformation of high-Mn steels was strongly influenced by SFE determining TRIP and TWIP effects. Tensile strength was the most important parameter in determining the resistance to high cycle fatigue ofmore » high-Mn steels with an exceptional work hardening capability at room and cryogenic temperatures. The fatigue crack nucleation mechanism in high-Mn steels did not vary with decreasing tempertature, except Cr-added specimens with grain boundary cracking at 298 K and slip band cracking at 110 K. The EBSD (electron backscatter diffraction) analyses suggested that the deformation mechanism under fatigue loading was significantly different from tensile deformation which could be affected by TRIP and TWIP effects. - Highlights: •The resistances to HCF of various high-Mn steels were measured. •The variables affecting tensile and HCF behaviors of high-Mn steels were assessed. •The relationship between tensile and the HCF behaviors of high-Mn steels was established.« less

Transition-metal alloying of γ'-Ni3Al : Effects on the ideal uniaxial compressive strength from first-principles calculations

NASA Astrophysics Data System (ADS)

Wen, Minru; Wang, Chong-Yu

2018-01-01

The addition of transition-metal (TM) elements into the γ' precipitate phase of a Ni-based single-crystal superalloy can significantly affect its mechanical properties, including the intrinsic mechanical property of compressive strength. Using first-principles density functional calculations, the effects of 3 d (Sc-Zn), 4 d (Y-Cd), and 5 d (Hf-Au) TM alloying elements on the ideal uniaxial compressive strength of γ'-Ni3Al were investigated. The stress-strain relationships of pure Ni3Al under [100], [110], and [111] compressive loads and the site occupancy behavior of TM elements in Ni3Al were previously studied using a total-energy method based on density functional theory. Our results showed that the capacity of TM elements for strengthening the ideal compressive strength was associated with the d -electron number. The alloying elements with half-filled d bands (i.e., Cr, Mo, W, Tc, and Re) manifested the greatest efficacy for improving the ideal strength of Ni3Al under a deformation along the weakest compressive direction. Furthermore, the charge redistribution of Ni3Al doped with 5 d elements were also analyzed to understand the strengthening mechanisms of TM elements in the γ'-Ni3Al phase.

Small Open Reading Frames, Non-Coding RNAs and Repetitive Elements in Bradyrhizobium japonicum USDA 110

PubMed Central

Hahn, Julia; Tsoy, Olga V.; Thalmann, Sebastian; Čuklina, Jelena; Gelfand, Mikhail S.

2016-01-01

Small open reading frames (sORFs) and genes for non-coding RNAs are poorly investigated components of most genomes. Our analysis of 1391 ORFs recently annotated in the soybean symbiont Bradyrhizobium japonicum USDA 110 revealed that 78% of them contain less than 80 codons. Twenty-one of these sORFs are conserved in or outside Alphaproteobacteria and most of them are similar to genes found in transposable elements, in line with their broad distribution. Stabilizing selection was demonstrated for sORFs with proteomic evidence and bll1319_ISGA which is conserved at the nucleotide level in 16 alphaproteobacterial species, 79 species from other taxa and 49 other Proteobacteria. Further we used Northern blot hybridization to validate ten small RNAs (BjsR1 to BjsR10) belonging to new RNA families. We found that BjsR1 and BjsR3 have homologs outside the genus Bradyrhizobium, and BjsR5, BjsR6, BjsR7, and BjsR10 have up to four imperfect copies in Bradyrhizobium genomes. BjsR8, BjsR9, and BjsR10 are present exclusively in nodules, while the other sRNAs are also expressed in liquid cultures. We also found that the level of BjsR4 decreases after exposure to tellurite and iron, and this down-regulation contributes to survival under high iron conditions. Analysis of additional small RNAs overlapping with 3’-UTRs revealed two new repetitive elements named Br-REP1 and Br-REP2. These REP elements may play roles in the genomic plasticity and gene regulation and could be useful for strain identification by PCR-fingerprinting. Furthermore, we studied two potential toxin genes in the symbiotic island and confirmed toxicity of the yhaV homolog bll1687 but not of the newly annotated higB homolog blr0229_ISGA in E. coli. Finally, we revealed transcription interference resulting in an antisense RNA complementary to blr1853, a gene induced in symbiosis. The presented results expand our knowledge on sORFs, non-coding RNAs and repetitive elements in B. japonicum and related bacteria. PMID:27788207

Advanced Hard Real-Time Operating System, the Maruti Project. Part 2.

DTIC Science & Technology

1997-01-01

Real - Time Operating System , The Maruti Project DASG-60-92-C-0055 5b. Program Element # 62301E 6. Author(s...The maruti hard real - time " operating system . A CM SIGOPS, Operating Systems Review. 23:90-106, July 1989. 254 !1 110) C. L. Liu and J. Layland...February 14, 1995 Abstract The Maruti Real - Time Operating System was developed for applications that must meet hard real-time constraints. In order

76 FR 54410 - Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of Pennsylvania...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

...), (G), (H), (J), (K), (L), and (M), or portions thereof; and the following infrastructure elements for the 2006 PM 2.5 NAAQS: 110(a)(2)(A), (B), (C), (D), (E), (F), (G), (H), (J), (K), (L), and (M), or..., K, L, M. G, H, J , K, L, M. December 7, 2007 D(i)(II)PSD D(i)(II)PSD. June 6, 2008 C, D(i)(II)PSD, J...

Multi-Scale Ballistic Material Modeling of Cross-Plied Compliant Composites

DTIC Science & Technology

2009-01-01

PERFORMING ORGANIZATION REPORT NUMBER 19a. NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER Mica Grujicic 864-656-5639 3. DATES COVERED (From - To...Autodyn [ANSYS/Autodyn version 11.0, User Documentation, Century Dynamics Inc. a subsidiary of ANSYS Inc. (2007)] and ABA- QUS /Explicit [ABAQUS...matrix, Fig. 3(b). Bonding between the matrix and the filaments is represented using 7056 ‘‘cohesive” elements, (ABA- QUS /Explicit designation COH3D6

Cosmic-ray elemental abundances from 1 to 10 GeV per amu for boron through nickel

NASA Technical Reports Server (NTRS)

Dwyer, Robert; Meyer, Peter

1987-01-01

The relative abundances of cosmic-ray nuclei in the charge range boron through nickel over the energy range 1-10 GeV per amu were measured with a balloon-borne detector. The instrument consists of a scintillation and Cerenkov counter telescope with a multiwire proportional chamber hodoscope and has been flown in four high-altitude balloon flights. Good charge resolution (sigma = 0.2 charge units at iron) and high statistical accuracy have been achieved. These data are used to derive the energy dependence of the leakage path length using the leaky box model of propagation and confinement in the galaxy. This energy dependence is found to be best fit by lambda = E(tot) exp -n, where n = 0.49 + or - 0.06 over 1-10 GeV per amu. Relative abundances at the source are consistent with an energy-independent composition.

Experiments on the Synthesis of Superheavy Elements with 48CA Beams at the Separator Vassilissa

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Yeremin, A. V.; Belozerov, A. V.; Chelnokov, M. L.; Chepigin, V. I.; Gorshkov, V. A.; Kabachenko, A. P.; Korotkov, S. P.; Malyshev, O. N.; Popeko, A. G.; Roháč, J.; Sagaidak, R. N.; Hofmann, S.; Münzenberg, G.; Veselsky, M.; Saro, S.; Iwasa, N.; Morita, K.; Giardina, G.

2001-04-01

The study of the decay properties and formation cross sections of the isotopes of elements 110, 112 and 114 were performed at the FLNR JINR with the use of the high intensity 48Ca beams and an electrostatic separator VASSILISSA. 232Th, 238U and 242Pu targets were used in the experiments. At the beam energies corresponding to the calculated cross section maxima of the 3n evaporation channels the isotopes 277110, 283112 and 287114 were produced and identified. The cross section limits were obtained at excitation energies of the compound nucleus corresponding to the maxima of the 4n evaporation channels for the reactions with 232Th and 238U targets.

Method of recovering hazardous waste from phenolic resin filters

DOEpatents

Meikrantz, David H.; Bourne, Gary L.; McFee, John N.; Burdge, Bradley G.; McConnell, Jr., John W.

1991-01-01

The invention is a process for the recovery of hazardous wastes such as heavy metals and radioactive elements from phenolic resin filter by a circulating a solution of 8 to 16 molar nitric acid at a temperature of 110 to 190 degrees F. through the filter. The hot solution dissolves the filter material and releases the hazardous material so that it can be recovered or treated for long term storage in an environmentally safe manner.

Complete Genome Sequence of a Cylindrospermopsin-Producing Cyanobacterium, Cylindrospermopsis raciborskii CS505, Containing a Circular Chromosome and a Single Extrachromosomal Element.

PubMed

Fuentes-Valdés, Juan J; Plominsky, Alvaro M; Allen, Eric E; Tamames, Javier; Vásquez, Mónica

2016-08-25

Cylindrospermopsis raciborskii is a freshwater cyanobacterium producing bloom events and toxicity in drinking water source reservoirs. We present the first genome sequence for C. raciborskii CS505 (Australia), containing one 4.1-Mbp chromosome and one 110-Kbp plasmid having G+C contents of 40.3% (3933 genes) and 39.3% (111 genes), respectively. Copyright © 2016 Fuentes-Valdés et al.

Finite Element Method of Stress Analysis of Nonaxisymmetric Configurations

DTIC Science & Technology

1980-04-01

UC(3*(KK-1)+I+12) = B(3*NP2-3+I) 110 CONTINUE DO 115 KK=1,24 115 UT(KK) = FfG(KK+(NS-1)»12) WRITE(6,900) 900 FORMAT(" "," EL SIGMAR SIGMAZ...1,12) 126 WHiT£(6,200i) T(N),(£PS(I),I=1,12) 200 CONTINUE 2000 FORMAT(129H1 EL fi Z SIGMAR SIGMAZ 3IGMAC SiGMA 1RZ SiGMAZC SIGMACH

Bioconcentration factors (BCF) of silver in wild Agaricus campestris

DOE Office of Scientific and Technical Information (OSTI.GOV)

Falandysz, J.; Danisiewicz, D.

Silver is an element naturally occurring in small concentrations in different environmental sites. However, many anthropogenic sources of silver led to contamination of this element in soil surfaces, pastures, and coastal marine areas in different parts of the world. Estimates are that 40% of the 1.15x10{sup 4}t of silver produced annually worldwide, will escape into the environment. Due to municipal waste discharge and/or industrial effluents with high silver concentrations, 100 x above the background level have been reported in invertebrate species from polluted marine areas. The meta-stabile radioisotope, {sup 110m}Ag, is a main component of the liquid effluents from nuclearmore » facilities under normal operating conditions. The presence of {sup 111}Ag and {sup 110m}Ag also has been widely found throughout Europe in the 1986 Chernobyl fallout. Silver ions are environmentally harmful. High toxic effects have been observed at low concentrations, especially in aquatic species. Species of lower fungi as well as the mushroom Agaricus bisporus are know to bioaccumulate high concentrations of silver when grown on an artificially enriched substrate. This study looks at the relationship between the silver content of soil and bioconcentration potential of wild Agaricus campestris from sites under different use and with different concentrations of heavy metals. 28 refs., 2 figs., 2 tabs.« less

77 FR 6711 - Approval and Promulgation of Implementation Plans; Arkansas; Infrastructure Requirements for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

...EPA is proposing to partially approve and partially disapprove submittals from the state of Arkansas pursuant to the Clean Air Act (CAA or Act) that address the infrastructure elements specified in the CAA section 110(a)(2), necessary to implement, maintain, and enforce the 1997 8-hour ozone and the 1997 and 2006 fine particulate matter (PM2.5) national ambient air quality standards (NAAQS or standards). We are proposing to find that the current Arkansas State Implementation Plan (SIP) meets the following infrastructure elements for the 1997 8-hour ozone NAAQS and the 1997 and 2006 PM2.5 NAAQS: 110(a)(2)(A), (B), (E), (F), (G), (H), (K), (L), (M), and portions of (C), (D)(ii) and (J). We are proposing to find that the current Arkansas SIP does not meet the infrastructure requirements for the 1997 8-hour ozone NAAQS and the 1997 and 2006 PM2.5 NAAQS at 110(a)(2) for portions of (C), (D)(ii), and (J) because the EPA-approved SIP prevention of significant deterioration (PSD) program does not apply to greenhouse gas (GHG) emitting sources. We also are proposing to find that the current Arkansas SIP does not meet the infrastructure requirements for the 1997 and 2006 PM2.5 NAAQS at 110(a)(2) for portions of (C), (D)(ii), and (J) because Arkansas has not submitted the PSD SIP revision required by EPA's Implementation of the New Source Review (NSR) Program for Particulate Matter Less Than 2.5 Micrometers (73 FR 28321, May 16, 2008). Further, we are proposing to partially approve and partially disapprove the provisions of SIP submissions that emissions from sources in Arkansas do not interfere with measures required in the SIP of any other state under part C of the CAA to prevent significant deterioration of air quality, with regard to the 1997 8-hour ozone NAAQS and the 2006 PM2.5 NAAQS. The partial disapprovals herein are because Arkansas cannot issue permits for GHG emissions and because the State did not submit the required PM2.5 PSD SIP revision. Finally, for purposes of the 1997 8-hour ozone NAAQS, EPA is proposing to approve SIP revisions that modify the Arkansas PSD SIP to include nitrogen oxides (NOX) as an ozone precursor. This action is being taken under section 110 and part C of the Act. Finally, EPA is also proposing to make a correction to the attainment status table in 40 CFR 81.304 to accurately reflect the redesignation date of Crittenden County, Arkansas to attainment for the 1997 8-hour ozone standard.

A novel hsp110-related gene, apg-1, that is abundantly expressed in the testis responds to a low temperature heat shock rather than the traditional elevated temperatures.

PubMed

Kaneko, Y; Nishiyama, H; Nonoguchi, K; Higashitsuji, H; Kishishita, M; Fujita, J

1997-01-31

We isolated a novel hsp110-related gene, apg-1, from a testis cDNA library. The apg-1 transcripts were constitutively expressed in the testicular germ cells and, in some degree, most tissues examined. In a mouse TAMA26 Sertoli cell line, apg-1 transcripts were induced in 2 h by a temperature shift from 32 to 39 degrees C, but not by a shift from 37 to 42 degrees C, the traditional heat stress, or a shift from 32 to 42 degrees C. The heat response pattern of hsp110 expression was similar to that of apg-1. Although induction of a hsp70 transcript was observed in 2 h by a shift from 32 to 39 degrees C, the induction was more apparent by a shift from 37 to 42 degrees C or from 32 to 42 degrees C. Essentially similar differential response patterns were observed among these genes in NIH/3T3 fibroblasts as well. The nuclear run-on assay and the native gel mobility shift assay demonstrated that, by the 32 to 39 degrees C temperature shift, the apg-1 gene was transcriptionally activated, and heat shock factor 1 bound to the heat shock elements in the 5'-flanking region of the apg-1 gene. These results demonstrated that expressions of apg-1, hsp110, and hsp70 could be heat-induced at a temperature lower than the traditional elevated temperatures in somatic cells of both testis and nontestis origin and suggest that the mechanisms regulating the transcript levels of apg-1 and hsp110 are different from those of hsp70. Furthermore, the constitutive expression in germ cells suggests that APG-1 plays a specific role in spermatogenesis as well as in stress response.

The effects of structural variations of thiophene-containing Ru(II) complexes on the acid-base and DNA binding properties.

PubMed

Yuan, Cui-Li; Zhang, An-Guo; Zheng, Ze-Bo; Wang, Ke-Zhi

2013-03-01

A phenylthiophenyl-bearing Ru(II) complex of [Ru(bpy)₂(Hbptip)](PF₆)₂ {bpy = 2,2'-bipyridine, Hbptip = 2-(4-phenylthiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline} was synthesized and characterized by elemental analysis, ¹H NMR spectroscopy, and electrospray ionization mass spectrometry. The ground- and excited-state acid-base properties of the complex were studied by UV-visible absorption and photoluminescence spectrophotometric pH titrations and the negative logarithm values of the ground-state acid ionization constants were derived to be pK(a1) = 1.31 ± 0.09 and pK(a2) = 5.71 ± 0.11 with the pK(a2) associated deprotonation/protonation process occurring over 3 pK(a) units more acidic than thiophenyl-free parent complex of [Ru(bpy)₂(Hpip)]²⁺ {Hpip = 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline}. The calf thymus DNA-binding properties of [Ru(bpy)₂(Hbptip)]²⁺ in Tris-HCl buffer (pH 7.1 and 50 mM NaCl) were investigated by DNA viscosities and density functional theoretical calculations as well as UV-visible and emission spectroscopy techniques of UV-visible and luminescence titrations, steady-state emission quenching by [Fe(CN)₆]⁴⁻, DNA competitive binding with ethidium bromide, DNA melting experiments, and reverse salt effects. The complex was evidenced to bind to the DNA intercalatively with binding affinity being greater than those for previously reported analogs of [Ru(bpy)₂(Hip)]²⁺, [Ru(bpy)₂(Htip)]²⁺, and [Ru(bpy)₂(Haptip)]²⁺ {Hip = 1H-imidazo[4,5-f][1,10]phenanthroline, Htip = 2-thiophenimidazo[4,5-f][1,10]phenanthroline, Haptip = 2-(5-phenylthiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline}.

Geothermal chemical elements in lichens of Yellowstone National Park

USGS Publications Warehouse

Bennett, J.P.; Wetmore, C.M.

1999-01-01

Geothermal features (e.g. geysers, fumaroles, vents, and springs) emit gaseous mercury, sulfur and heavy metals and therefore, are natural sources of these elements in the atmosphere. Field studies of heavy metals in lichens in Italy have detected elevated concentrations near geothermal power plants, and have determined that the origin of mercury is from soil degassing, not soil particles. We studied this phenomenon in a geothermal area without power plants to determine the natural levels of mercury and other elements. Two common and abundant species of epiphytic Lichens, Bryoria fremontii and Letharia vulpina, were collected at six localities in Yellowstone National Park, USA in 1998 and analyzed for 22 chemical elements. Thirteen elements differed significantly between species. Some elements were significantly higher in the southern part of the park, while others were higher in the north. Levels of most elements were comparable with those in other national parks and wilderness areas in the region, except Hg, which was unusually high. The most likely sources of this element are the geothermal features, which are known emitters of Hg. Multivariate analyses revealed strong positive associations of Hg with S, and negative associations with soil elements, providing strong evidence that the Hg in the lichens is the result of soil degassing of elemental Hg rather than particulate Hg directly from soils. Average Hg levels in the lichens were 140 p.p.b. in Bryoria and 110 p.p.b. in Letharia, but maxima were 291 and 243 p.p.b., respectively. In spite of this, both species were healthy and abundant throughout the park.

A comparison of several techniques to assign heights to cloud tracers

NASA Technical Reports Server (NTRS)

Nieman, Steven J.; Schmetz, Johannes; Menzel, W. P.

1993-01-01

Experimental results are presented which suggest that the water-vapor technique of radiance measurement is a viable alternative to the CO2 technique for inferring the height of semitransparent cloud elements. Future environmental satellites will rely on H2O-derived cloud-height assignments in the wind-field determinations with the next operational geostationary satellite. On a given day, the heights from the H2O and CO2 approaches compare to within 60-110 hPa rms.

Osculating Keplerian Elements for Highly Non-Keplerian Orbits

DTIC Science & Technology

2017-03-27

1.52133 2 McInnes, C. R., “The Existence and Stability of Families of Displacement Two-Body Orbits”, Celestial Mechanics and Dynamical Astronomy , Vol...j.actaastro.2011.08.012 5 Xu, M. and Xu, S., “Nonlinear dynamical analysis for displaced orbits above a planet”, Celestial Mechanics and Dynamical Astronomy ...Celestial Mechanics and Dynamical Astronomy , Vol. 110, No. 3, 2011, pp. 199-215. doi: 10.1007/s10569-011-9351-5 7 Macdonald, M., McKay, R. J., Vasile, M

The Higher Education Act: Approaches to College Preparation. Hearing before the Subcommittee on Higher Education, Lifelong Learning, and Competitiveness. Committee on Education and Labor, U.S. House of Representatives, One Hundred Tenth Congress, First Session (March 22, 2007). Serial Number 110-13

ERIC Educational Resources Information Center

US House of Representatives, 2007

2007-01-01

This hearing, the second of three on the reauthorization of the Higher Education Act, discussed some of the key federal elements in college preparation and outreach, as well as state and private-sector initiatives. Participating members and witnesses included: Honorable Ruben Hinojosa, Chairman, Subcommittee on Higher Education, Lifelong Learning,…

GRAIN BOUNDARY STRENGTHENING PROPERTIES OF TUNGSTEN ALLOYS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Setyawan, Wahyu; Kurtz, Richard J.

2012-10-10

Density functional theory was employed to investigate grain boundary (GB) properties of W alloys. A range of substitutional solutes across the Periodic Table was investigated to understand the behavior of different electronic orbitals in changing the GB cleavage energy in the Σ27a[110]{525} GB. A number of transition metals were predicted to enhance the GB cohesion. This includes Ru, Re, Os, Ir, V, Cr, Mn, Fe, Co, Ti, Hf, Ta and Nb. While lanthanides, s and p elements were tended to cause GB embrittlement.

Minor elements in Quaternary sediment from the Sea of Japan: a record of surface-water productivity and intermediate-water redox conditions

USGS Publications Warehouse

Piper, D.Z.; Isaacs, C.M.

1995-01-01

Records six episodes of high accumulation rates of Cd, Cr, Cu, Mo, Ni, U, V, and Zn. The high rates correspond to periods of sulfate reduction in the water column at the intermediate depth of Oki Ridge; the intervening low values correspond to periods of denitrification and oxygen respiration. The maxima have a period of 41 k.y., the youngest having an age of 1.10 Ma. -from Authors

Application of Artificial Boundary Conditions in Sensitivity-Based Updating of Finite Element Models

DTIC Science & Technology

2007-06-01

is known as the impedance matrix[ ]( )Z Ω . [ ] [ ] 1( ) ( )Z H −Ω = Ω (12) where [ ] 2( )Z K M j C ⎡ ⎤Ω = −Ω + Ω⎣ ⎦ (13) A. REDUCED ORDER...D.L. A correlation coefficient for modal vector analysis. Proceedings of 1st International Modal Analysis Conference, 1982, 110-116. Anton , H ... Rorres , C ., (2005). Elementary Linear Algebra. New York: John Wiley and Sons. Avitable, Peter (2001, January) Experimental Modal Analysis, A Simple

Trace element and petrologic clues to the formation of forsterite-bearing Ca-Al-rich inclusions in the Allende meteorite

NASA Astrophysics Data System (ADS)

Wark, D. A.; Boynton, W. V.; Keays, R. R.; Palme, H.

1987-03-01

This work presents new trace element and petrographic data for three forsterite-bearing, Ca-Al-rich inclusions from the Allende meteorite: TE, 818a, and 110-A. Such inclusions form a continuum with Type B1 and B2 Ca-Al-rich inclusions (CAIs), and the authors refer to them as "Type B3" CAIs. Textures, mineral chemistries, crystal-chemically fractionated REE patterns, and other properties suggest that Type B3 crystallized from partly molten evaporative residues. They also present evidence that 818a was strongly re-heated and modified in the nebula after its initial crystallization: it consists of a core of coarse-grained Ti-Al-pyroxene (Tpx), forsterite, spinel and metal grains and a thick, surrounding mantle of melilite.

Survival-mediated capture and fusion cross sections for heavy-element synthesis

NASA Astrophysics Data System (ADS)

Yao, L.; Loveland, W.

2018-01-01

The cross section for producing a heavy evaporation residue σEVR in a fusion reaction can be written as a product of three nonseparable factors, i.e., the capture cross section, the fusion probability PCN, and the survival probability Wsur. Each of these factors is dependent on the spin. However, one must remember that the Wsur term is zero or very small for higher spin values, thus effectively limiting the capture and fusion terms. For a series of ˜287 reactions leading to heavy evaporation residues with ZCN≤110 , we point out the implications of this fact for capture cross sections for heavy element formation reactions. From a comparison of calculated and measured evaporation residue cross sections we deduce values of the fusion probability PCN for some of these reactions.

Reorientation-effect measurement of the <21+∥E2̂∥21+> matrix element in 10Be

NASA Astrophysics Data System (ADS)

Orce, J. N.; Drake, T. E.; Djongolov, M. K.; Navrátil, P.; Triambak, S.; Ball, G. C.; Al Falou, H.; Churchman, R.; Cross, D. S.; Finlay, P.; Forssén, C.; Garnsworthy, A. B.; Garrett, P. E.; Hackman, G.; Hayes, A. B.; Kshetri, R.; Lassen, J.; Leach, K. G.; Li, R.; Meissner, J.; Pearson, C. J.; Rand, E. T.; Sarazin, F.; Sjue, S. K. L.; Stoyer, M. A.; Sumithrarachchi, C. S.; Svensson, C. E.; Tardiff, E. R.; Teigelhoefer, A.; Williams, S. J.; Wong, J.; Wu, C. Y.

2012-10-01

The highly-efficient and segmented TIGRESS γ-ray spectrometer at TRIUMF has been used to perform a reorientation-effect Coulomb-excitation study of the 21+ state at 3.368 MeV in 10Be. This is the first Coulomb-excitation measurement that enables one to obtain information on diagonal matrix elements for such a high-lying first excited state from γ-ray data. With the availability of accurate lifetime data, a value of -0.110±0.087 eb is determined for the <21+∥E2̂∥21+> diagonal matrix element, which assuming the rotor model, leads to a negative spectroscopic quadrupole moment of QS(21+)=-0.083±0.066 eb. This result is in agreement with both no-core shell-model calculations performed in this work with the CD-Bonn 2000 two-nucleon potential and large shell-model spaces, and Green's function Monte Carlo predictions with two- plus three-nucleon potentials.

A high-resolution study of ultra-heavy cosmic-ray nuclei (A0178)

NASA Technical Reports Server (NTRS)

Osullivan, D.; Thompson, A.; Oceallaigh, C.; Domingo, V.; Wenzel, K. P.

1984-01-01

The main objective of the experiment is a detailed study of the charge spectra of ultraheavy cosmic-ray nuclei from zinc (Z = 30) to uranium (Z = 92) and beyond using solid-state track detectors. Special emphasis will be placed on the relative abundances in the region Z or - 65, which is thought to be dominated by r-process nucleosynthesis. Subsidiary objectives include the study of the cosmic-ray transiron spectrum a search for the postulated long-lived superheavy (SH) nuclei (Z or = 110), such as (110) SH294, in the contemporary cosmic radiation. The motivation behind the search for super-heavy nuclei is based on predicted half-lives that are short compared to the age of the Earth but long compared to the age of cosmic rays. The detection of such nuclei would have far-reaching consequences for nuclear structure theory. The sample of ultraheavy nuclei obtained in this experiment will provide unique opportunities for many tests concerning element nucleosynthesis, cosmic-ray acceleration, and cosmic-ray propagation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Che, Guang-Bo, E-mail: guangboche@jlnu.edu.cn; Liu, Shu-Yu; Zhang, Qing

Four new lanthanide complexes [Ln(O–NCP){sub 2}(NO{sub 3})]{sub n} based on multifunctional N,O-donor ligand 2-(2-carboxyphenyl)imidazo(4,5-f)-(1,10)phenanthroline (O–HNCP) and Ln(NO{sub 3}){sub 3}·6H{sub 2}O (Ln=Nd(1), La(2), Sm(3), Eu(4)) have been achieved under hydrothermal conditions and characterized by elemental analyses, infrared spectra and single crystal X-ray diffraction. Structural analyses revealed that all of these four complexes possess similar two-dimensional layer structures. In addition, thermal stability and luminescent properties of these complexes were also investigated. - Graphical abstract: A series of lanthanide(III) coordination polymers with intriguing structures based on 2-(2-carboxyphenyl)imidazo(4,5-f)-(1,10)phenanthroline ligand have been hydrothermally synthesized. The thermal stabilities and photoluminescence properties of these complexes have beenmore » investigated. - Highlights: • Four lanthanide(III) complexes have been hydrothermally synthesized. • The N,O-donor O–HNCP was used as the ligand. • TGA and PL properties of complexes 1–4 have been investigated.« less

Modeling electrical double-layer effects for microfluidic impedance spectroscopy from 100 kHz to 110 GHz.

PubMed

Little, Charles A E; Orloff, Nathan D; Hanemann, Isaac E; Long, Christian J; Bright, Victor M; Booth, James C

2017-07-25

Broadband microfluidic-based impedance spectroscopy can be used to characterize complex fluids, with applications in medical diagnostics and in chemical and pharmacological manufacturing. Many relevant fluids are ionic; during impedance measurements ions migrate to the electrodes, forming an electrical double-layer. Effects from the electrical double-layer dominate over, and reduce sensitivity to, the intrinsic impedance of the fluid below a characteristic frequency. Here we use calibrated measurements of saline solution in microfluidic coplanar waveguide devices at frequencies between 100 kHz and 110 GHz to directly measure the double-layer admittance for solutions of varying ionic conductivity. We successfully model the double-layer admittance using a combination of a Cole-Cole response with a constant phase element contribution. Our analysis yields a double-layer relaxation time that decreases linearly with solution conductivity, and allows for double-layer effects to be separated from the intrinsic fluid response and quantified for a wide range of conducting fluids.

Linear combination of atomic orbitals calculation of the Auger neutralization rate of He{sup +} on Al(111) (100), and (110) surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Valdes, Diego; Blanco, J.M.; Monreal, R.C.

2005-06-15

We develop a theory of the Auger neutralization rate of ions on solid surfaces in which the matrix elements for the transition are calculated by means of a linear combination of atomic orbitals technique. We apply the theory to the calculation of the Auger rate of He{sup +} on unreconstructed Al(111) (100), and (110) surfaces, assuming He{sup +} to approach these surfaces on high symmetry positions and compare them with the results of the jellium model. Although there are substantial differences between the Auger rates calculated with both kinds of approaches, those differences tend to compensate when evaluating the integralmore » along the ion trajectory and, consequently, are of minor influence in some physical magnitudes like the ion survival probability for perpendicular energies larger than 100 eV. We find that many atoms contribute to the Auger process and small effects of lateral corrugation are registered.« less

Optical second harmonic generation from Pt nanowires with boomerang-like cross-sectional shapes

NASA Astrophysics Data System (ADS)

Ogata, Yoichi; Anh Tuan, Nguyen; Miyauchi, Yoshihiro; Mizutani, Goro

2011-08-01

We have fabricated Pt nanowires with boomerang-like cross-sectional shapes on the MgO(110) faceted template and observed their optical second-harmonic generation (SHG) response. In the TEM images the Pt nanowires on the MgO substrate had macroscopic C2v symmetry, however, their structure had microscopic imperfections. In the SHG response, as a function of the sample rotation angle around the substrate normal, we found contributions from the nonlinear susceptibility elements χ113, χ223, χ311, χ322, and χ333 originating from the broken symmetry in the 3; [110] direction of the MgO substrate. The indices 1 and 2 denote the [001] and [11¯0] directions, respectively. Under C2v symmetry no SHG is expected in the s-in/s-out polarization configuration, however, a finite SHG was observed in this polarization configuration. We suggest that the SHG in the forbidden configuration might originate from the imperfections in the nanowire structure.

Five novel lanthanide complexes with 2-chloroquinoline-4-carboxylic acid and 1,10-phenanthroline: Crystal structures, molecular spectra, thermal properties and bacteriostatic activities

NASA Astrophysics Data System (ADS)

Wang, Ye; Jin, Cheng-Wei; He, Shu-Mei; Ren, Ning; Zhang, Jian-Jun

2016-12-01

Five novel lanthanide complexes [Ln2(2-ClQL)6(phen)2(H2O)2]·2H2O (Ln = Pr(1), Sm(2), Eu(3), Ho(4), Er(5)); 2-ClQL: 2-chloroquinoline-4-carboxylate; phen: 1,10-phenanthroline; were synthesized by conventional solution method at room temperature and characterized via elemental analysis, powder x-ray diffraction, Infrared spectroscopy and Raman spectrometry. The results indicate that complexes 1-5 are isostructural, and each Ln3+ ion is eight-coordinated adopting a distorted square antiprismatic molecular geometry. Binuclear complex 1 are stitched together via hydrogen bonding interactions to form 1D chains, and further to form 2D sheets by the π-π interactions. Luminescence investigation reveals that complex 3 displays strong red emission. TG/DTG-FTIR, reveal the thermal decomposition processes and products of title complexes. The bacteriostatic activities of the complexes were evaluated against Candida albicans, Escherichia coli, and Staphylococcus aureus.

Anticancer, antibacterial and antifungal activity of new ni (ii) and cu (ii) complexes of imidazole-phenanthroline derivatives.

PubMed

Moghadam, Mahboube Eslami; Divsalar, Adeleh; Zare, Marziye Shahraki; Gholizadeh, Roghayeh; Mahalleh, Doran; Saghatforosh, Lotfali; Sanati, Soheila

2017-11-02

Two new nickel(II) and copper(II) complexes of 2-(Furan-2-yl)-1H-Imidazo[4,5-f][1,10]Phenanthroline (FIP) and 2-(thiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (TIP), imidazophen derivatives were synthesized. The structures of the compounds were determined by UV-visible and FT-IR spectroscopic methods and elemental analysis. The biological activities of Ni and Cu complexes, as anticancer agents, were tested against chronic myelogenous leukemia cell line, K562, at micromolar concentration. The MTT studies showed Cc 50 values are 21 and 160 µM for Cu and Ni(II) complexes, respectively; suggesting that Ni (II) complex has Cc 50 almost seven times of that obtained for cisplatin. Biological activity of the Ni(II) and Cu(II) complexes were also assayed against selective microorganisms by disc diffusion method. These results showed that the Cu(II) complex is antifungal agent but Ni(II) complex has antibacterial activity.

Relationship of Optical Anomalies, Zoning, and Microtopography in Vesuvianite from Jeffrey Mine, Asbestos, Quebec

NASA Astrophysics Data System (ADS)

Smith, Varina Campbell

The role of growth steps in inducing disequilibrium is investigated in crystals of vesuvianite from the Jeffrey mine, Asbestos, Quebec, using optical microscopy, atomic force microscopy, electron microprobe analysis, and single-crystal X-ray diffraction. The selective uptake of elements Fe and Al by asymmetric growth-steps on three crystallographic forms, {100}, {110}, and {121}, is documented. The prisms {100} and {110} show hillocks that display kinetically controlled oscillatory zoning along growth steps parallel to <010> and <11¯1>, but not on vicinal faces defined by [001] steps. Sector-specific zoning of extinction angles and 2V angles indicate different degrees of optical dissymmetrization in crystals spanning a range of growth habits. Unit-cell parameters and the presence of violating reflections confirm sectoral deviations from P4/nnc symmetry in the prismatic sectors. The partial loss of three glide planes follows the pattern expected from order of the cations Al and Fe induced by tangential selectivity at the edge of non-equivalent steps during layer-by-layer growth.

Spectrophotometric determination of vanadium in rutile and in mafic igneous rocks

USGS Publications Warehouse

Marinenko, John; Mei, Leung

1974-01-01

Minor and major levels of vanadium in rutile are separated from titanium and iron by sample fusion with sodium carbonate followed by water leach and filtration. The filtrate is then acidified with hydrochloric acid. Silicates are decomposed with a mixture of hydrofluoric and hydrochloric acids, and iron is separated by extraction of its chloride with diethyl ether. Sample vanadium in hydrochloric acid is then quantitatively reduced to vanadium(IV) with sulfurous acid. The remaining sulfur dioxide is expelled by heating. Vanadium (IV) then is reacted with excess of iron(III) at reduced acidity (pH 5) in the presence of 1,10-phenanthroline to yield the orange-red iron(II) 1,10-phenanthroline complex. Iron(II) generated by vanadium(IV) is a measure of total vanadium in the sample. The proposed method is free from elemental interferences because the color development cannot take place without the two redox reactions described above, and these are, under the outlined experimental conditions, quantitative only for vanadium.

Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population.

PubMed

Cai, Lei; Chen, Tianlu; Yang, Jinglei; Zhou, Kejun; Yan, Xiaomei; Chen, Wenzhong; Sun, Liya; Li, Linlin; Qin, Shengying; Wang, Peng; Yang, Ping; Cui, Donghong; Burmeister, Margit; He, Lin; Jia, Wei; Wan, Chunling

2015-10-12

Little is known about the trace element profile differences between Schizophrenia patients and healthy controls; previous studies about the association of certain elements with Schizophrenia have obtained conflicting results. To identify these differences in the Han Chinese population, inductively coupled plasma-mass spectrometry was used to quantify the levels of 35 elements in the sera of 111 Schizophrenia patients and 110 healthy participants, which consisted of a training (61/61 for cases/controls included) and a test group including remaining participants. An orthogonal projection to latent structures model was constructed from the training group (R(2)Y = 0.465, Q(2)cum = 0.343) had a sensitivity of 76.0% and a specificity of 71.4% in the test group. Single element analysis indicated that the concentrations of cesium, zinc, and selenium were significantly reduced in patients with Schizophrenia in both the training and test groups. The meta-analysis including 522 cases and 360 controls supported that Zinc was significantly associated with Schizophrenia (standardized mean difference [SMD], -0.81; 95% confidence intervals [CI], -1.46 to -0.16, P = 0.01) in the random-effect model. Information theory analysis indicated that Zinc could play roles independently in Schizophrenia. These results suggest clear element profile differences between patients with Schizophrenia and healthy controls, and reduced Zn level is confirmed in the Schizophrenia patients.

Rare earth element recycling from waste nickel-metal hydride batteries.

PubMed

Yang, Xiuli; Zhang, Junwei; Fang, Xihui

2014-08-30

With an increase in number of waste nickel-metal hydride batteries, and because of the importance of rare earth elements, the recycling of rare earth elements is becoming increasingly important. In this paper, we investigate the effects of temperature, hydrochloric acid concentration, and leaching time to optimize leaching conditions and determine leach kinetics. The results indicate that an increase in temperature, hydrochloric acid concentration, and leaching time enhance the leaching rate of rare earth elements. A maximum rare earth elements recovery of 95.16% was achieved at optimal leaching conditions of 70°C, solid/liquid ratio of 1:10, 20% hydrochloric acid concentration, -74μm particle size, and 100min leaching time. The experimental data were best fitted by a chemical reaction-controlled model. The activation energy was 43.98kJ/mol and the reaction order for hydrochloric acid concentration was 0.64. The kinetic equation for the leaching process was found to be: 1-(1-x)(1/3)=A/ρr0[HCl](0.64)exp-439,8008.314Tt. After leaching and filtration, by adding saturated oxalic solution to the filtrate, rare earth element oxalates were obtained. After removing impurities by adding ammonia, filtering, washing with dilute hydrochloric acid, and calcining at 810°C, a final product of 99% pure rare earth oxides was obtained. Copyright © 2014 Elsevier B.V. All rights reserved.

Extrachromosomal genetic elements in Micrococcus.

PubMed

Dib, Julián Rafael; Liebl, Wolfgang; Wagenknecht, Martin; Farías, María Eugenia; Meinhardt, Friedhelm

2013-01-01

Micrococci are Gram-positive G + C-rich, nonmotile, nonspore-forming actinomycetous bacteria. Micrococcus comprises ten members, with Micrococcus luteus being the type species. Representatives of the genus play important roles in the biodegradation of xenobiotics, bioremediation processes, production of biotechnologically important enzymes or bioactive compounds, as test strains in biological assays for lysozyme and antibiotics, and as infective agents in immunocompromised humans. The first description of plasmids dates back approximately 28 years, when several extrachromosomal elements ranging in size from 1.5 to 30.2 kb were found in Micrococcus luteus. Up to the present, a number of circular plasmids conferring antibiotic resistance, the ability to degrade aromatic compounds, and osmotolerance are known, as well as cryptic elements with unidentified functions. Here, we review the Micrococcus extrachromosomal traits reported thus far including phages and the only quite recently described large linear extrachromosomal genetic elements, termed linear plasmids, which range in size from 75 kb (pJD12) to 110 kb (pLMA1) and which confer putative advantageous capabilities, such as antibiotic or heavy metal resistances (inferred from sequence analyses and curing experiments). The role of the extrachromosomal elements for the frequently proven ecological and biotechnological versatility of the genus will be addressed as well as their potential for the development and use as genetic tools.

Development of microchannel plate x-ray optics

NASA Technical Reports Server (NTRS)

Kaaret, Philip; Chen, Andrew

1994-01-01

The goal of this research program was to develop a novel technique for focusing x-rays based on the optical system of a lobster's eye. A lobster eye employs many closely packed reflecting surfaces arranged within a spherical or cylindrical shell. These optics have two unique properties: they have unlimited fields of view and can be manufactured via replication of identical structures. Because the angular resolution is given by the ratio of the size of the individual optical elements to the focal length, optical elements with sizes on the order of one hundred microns are required to achieve good angular resolution with a compact telescope. We employed anisotropic etching of single crystal silicon wafers for the fabrication of micron-scale optical elements. This technique, commonly referred to as silicon micromachining, is based on silicon fabrication techniques developed by the microelectronics industry. An anisotropic etchant is a chemical which etches certain silicon crystal planes much more rapidly than others. Using wafers in which the slowly etched crystal planes are aligned perpendicularly to the wafer surface, it is possible to etch a pattern completely through a wafer with very little distortion. Our optics consist of rectangular pores etched completely through group of zone axes (110) oriented silicon wafers. The larger surfaces of the pores (the mirror elements) were aligned with the group of zone axes (111) planes of the crystal perpendicular to the wafer surface. We have succeeded in producing silicon lenses with a geometry suitable for 1-d focusing x-ray optics. These lenses have an aspect ratio (40:1) suitable for x-ray reflection and have very good optical surface alignment. We have developed a number of process refinements which improved the quality of the lens geometry and the repeatability of the etch process. A significant progress was made in obtaining good optical surface quality. The RMS roughness was decreased from 110 A for our initial lenses to 30 A in the final lenses. A further factor of three improvement in surface quality is required for the production of efficient x-ray optics. In addition to the silicon fabrication, an x-ray beam line was constructed at Columbia for testing the optics.

Syntheses, structures and luminescent properties of a series of 3D lanthanide coordination polymers with tripodal semirigid ligand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qin Junsheng; Department of Applied Chemistry, Jilin Institute of Chemical Technology, Jilin 132022; Du Dongying

2011-02-15

Reactions of the tripodal bridging ligand 5-(4-carboxy-phenoxy)-isophthalic acid (abbreviated as H{sub 3}cpia) with lanthanide salts lead to the formation of a family of different coordination polymers, that is, [Ln(cpia)(H{sub 2}O){sub 2}]{sub n}.nH{sub 2}O (Ln=Ce (1), Pr (2), Nd (3), Sm (4), Eu (5), Gd (6), Dy (7), Er (8), Tm (9) and Y (10)) in the presence of formic acid or diethylamine, which are characterized by elemental analysis, IR spectrum, thermogravimetric analysis (TGA), XRPD spectrum and single-crystal X-ray diffraction. Compounds 1-10 are isostructural and exhibit three-dimensional microporous frameworks. Furthermore, the photoluminescent properties of 4, 5 and 7 have been studiedmore » in detail. -- Graphical abstract: Reactions of the tripodal bridging ligand (H{sub 3}cpia) with lanthanide ions lead to the formation of a series of coordination polymers in the presence of formic acid or diethylamine. Display Omitted Research Highlights: {yields} Ten new lanthanides-based coordination polymers (1-10) have been synthesized. {yields} 1-10 exhibit 3D (4,8)-connected fluorite topology networks with 1D channel parallel to the b-axis. {yields} Compounds 4, 5 and 7 exhibit characteristic luminescence of Sm{sup 3+}, Eu{sup 3+} and Dy{sup 3+} ions, respectively.« less

The role of molecular chaperones in clathrin mediated vesicular trafficking

PubMed Central

Sousa, Rui; Lafer, Eileen M.

2015-01-01

The discovery that the 70 kD “uncoating ATPase,” which removes clathrin coats from vesicles after endocytosis, is the constitutively expressed Hsc70 chaperone was a surprise. Subsequent work, however, revealed that uncoating is an archetypal Hsp70 reaction: the cochaperone auxilin, which contains a clathrin binding domain and an Hsc70 binding J domain, recruits Hsc70*ATP to the coat and, concomitant with ATP hydrolysis, transfers it to a hydrophobic Hsc70-binding element found on a flexible tail at the C-terminus of the clathrin heavy chain. Release of clathrin in association with Hsc70*ADP follows, and the subsequent, persistent association of clathrin with Hsc70 is important to prevent aberrant clathrin polymerization. Thus, the two canonical functions of Hsp70—dissociation of existing protein complexes or aggregates, and binding to a protein to inhibit its inappropriate aggregation—are recapitulated in uncoating. Association of clathrin with Hsc70 in vivo is regulated by Hsp110, an Hsp70 NEF that is itself a member of the Hsp70 family. How Hsp110 activity is itself regulated to make Hsc70-free clathrin available for endocytosis is unclear, though at synapses it's possible that the influx of calcium that accompanies depolarization activates the Ca++/calmodulin dependent calcineurin phosphatase which then dephosphorylates and activates Hsp110 to stimulate ADP/ATP exchange and release clathrin from Hsc70*ADP:clathrin complexes. PMID:26042225

The decline of soil due to the pile of highway project Medan-Kualanamu (STA 35 + 901) with the finite element method

NASA Astrophysics Data System (ADS)

Hastuty, I. P.; Roesyanto; Sihite, A. B.

2018-02-01

Consolidation is the process of discharge of water from the ground through the pore cavity. Consolidation occurs in soft soil or unstable soil that allows an improvement in order to make the soil more stable. The method of using Prefabricated Vertical Drain (PVD) is one way to improve unstable soils. PVD works like a sand column that can drain water vertically. This study aims to determine the decrease, pore water pressure and soil consolidation rate with Prefabricated Vertical Drain (PVD) and without PVD analytically and using finite element method that affect the duration of soil decline to reach 90% consolidation or in other words soil does not decline anymore. Based on the analytical calculation, the decrease obtained is equal to 0.47 m meanwhile the result of calculation using finite element method is 0.45 m. The consolidation rate obtained from analytical calculation is 19 days with PVD and 115 days without PVD. The consolidation rate obtained from finite element method is 63 days with PVD and 110 days without PVD. And the pore water pressure is 0.92 KN/m2.

Length Scales of Reactive Transport in Basalt: Hydrothermal Flow-through Experiments and Anhydrite Precipitation

NASA Astrophysics Data System (ADS)

Los, C.; Kahl, W. A.; Bach, W.

2017-12-01

Hydrothermal circulation is a large contributor to mass and heat exchange between oceanic lithosphere and hydrosphere. Cold, unaltered seawater infiltrates in the shallow basaltic crust, leading to sulfate precipitation and clogging of fluid pathways. Anhydrite (CaSO4) veins are common in hydrothermal discharge zones, where entrained seawater is heated and anhydrite quickly forms. Anhydrite is also found in hydrothermal recharge zones, but questions regarding time and length scale in this setting remain. To investigate element transport and anhydrite precipitation we have conducted flow-through experiments using a gypsum-undersaturated CaSO4 solution in pre-fractured basalt at 95, 110 and 140°C. Each run was terminated upon clogging of the input tubes, which took 2-8 weeks. The rock core was scanned before the run and weekly during the experiment using X-ray tomography. Fluid major element chemistry was analyzed using ICP-OES. Geochemical modeling with the software package EQ3/6 showed that the starting solution became supersaturated in anhydrite (SI=IAP/K of 2.5 or higher) in all cases upon heating to the experimental temperature. The software CRUNCH FLOW was used to analyze chemical effects over the length of the core (3cm). The 95°C run and a first run at 110°C did not show any anhydrite. Instead, hematite rosettes and sulfur-bearing (maximum of 1 wt.%) globular Fe-rich structures were present. Tomography images showed that fractures and pores were slightly thinned over the whole core length. Single pores in a second 110°C run and fractures in the 140°C run did show formation of anhydrite and quartz close to the outlet. CRUNCH FLOW modeling predicts the observed release of Mg, Fe, Si, Al, Na and K due to silicate dissolution close to the inlet, while the outlet area should contain some anhydrite. No other sulfur-bearing phases were predicted. The results of this study show that anhydrite needs a large supersaturation (SI>2.5) to precipitate at temperatures below 110°C. This is easier accomplished close to the outlet, where the largest amount of cations is released from the rock. Iron dissolution from primary phases is fast, but its mobility is low as it is rapidly captured in hematite. Anhydrite and hematite precipitation do not seem to induce fracturing in the surrounding rock but close the pre-existing pore space.

A parametric study of hard tissue injury prediction using finite elements: consideration of geometric complexity, subfailure material properties, CT-thresholding, and element characteristics.

PubMed

Arregui-Dalmases, Carlos; Del Pozo, Eduardo; Duprey, Sonia; Lopez-Valdes, Francisco J; Lau, Anthony; Subit, Damien; Kent, Richard

2010-06-01

The objectives of this study were to examine the axial response of the clavicle under quasistatic compressions replicating the body boundary conditions and to quantify the sensitivity of finite element-predicted fracture in the clavicle to several parameters. Clavicles were harvested from 14 donors (age range 14-56 years). Quasistatic axial compression tests were performed using a custom rig designed to replicate in situ boundary conditions. Prior to testing, high-resolution computed tomography (CT) scans were taken of each clavicle. From those images, finite element models were constructed. Factors varied parametrically included the density used to threshold cortical bone in the CT scans, the presence of trabecular bone, the mesh density, Young's modulus, the maximum stress, and the element type (shell vs. solid, triangular vs. quadrilateral surface elements). The experiments revealed significant variability in the peak force (2.41 +/- 0.72 kN) and displacement to peak force (4.9 +/- 1.1 mm), with age (p < .05) and with some geometrical traits of the specimens. In the finite element models, the failure force and location were moderately dependent upon the Young's modulus. The fracture force was highly sensitive to the yield stress (80-110 MPa). Neither fracture location nor force was strongly dependent on mesh density as long as the element size was less than 5 x 5 mm(2). Both the fracture location and force were strongly dependent upon the threshold density used to define the thickness of the cortical shell.

Search for Majorana Neutrinos Near the Inverted Mass Hierarchy Region with KamLAND-Zen

NASA Astrophysics Data System (ADS)

Gando, A.; Gando, Y.; Hachiya, T.; Hayashi, A.; Hayashida, S.; Ikeda, H.; Inoue, K.; Ishidoshiro, K.; Karino, Y.; Koga, M.; Matsuda, S.; Mitsui, T.; Nakamura, K.; Obara, S.; Oura, T.; Ozaki, H.; Shimizu, I.; Shirahata, Y.; Shirai, J.; Suzuki, A.; Takai, T.; Tamae, K.; Teraoka, Y.; Ueshima, K.; Watanabe, H.; Kozlov, A.; Takemoto, Y.; Yoshida, S.; Fushimi, K.; Banks, T. I.; Berger, B. E.; Fujikawa, B. K.; O'Donnell, T.; Winslow, L. A.; Efremenko, Y.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Detwiler, J. A.; Enomoto, S.; Decowski, M. P.; KamLAND-Zen Collaboration

2016-08-01

We present an improved search for neutrinoless double-beta (0 ν β β ) decay of 136Xe in the KamLAND-Zen experiment. Owing to purification of the xenon-loaded liquid scintillator, we achieved a significant reduction of the Agm110 contaminant identified in previous searches. Combining the results from the first and second phase, we obtain a lower limit for the 0 ν β β decay half-life of T1/2 0 ν>1.07 ×1 026 yr at 90% C.L., an almost sixfold improvement over previous limits. Using commonly adopted nuclear matrix element calculations, the corresponding upper limits on the effective Majorana neutrino mass are in the range 61-165 meV. For the most optimistic nuclear matrix elements, this limit reaches the bottom of the quasidegenerate neutrino mass region.

The 1 MV multi-element AMS system for biomedical applications at the Netherlands Organization for Applied Scientific Research (TNO)

NASA Astrophysics Data System (ADS)

Klein, Matthias; Vaes, W. H. J.; Fabriek, B.; Sandman, H.; Mous, D. J. W.; Gottdang, A.

2013-01-01

The Netherlands Organization for Applied Scientific Research (TNO) has installed a compact 1 MV multi-element AMS system manufactured by High Voltage Engineering Europa B.V., The Netherlands. TNO performs clinical research programs for pharmaceutical and innovative foods industry to obtain early pharmacokinetic data and to provide anti-osteoporotic efficacy data of new treatments. The AMS system will analyze carbon, iodine and calcium samples for this purpose. The first measurements on blank samples indicate background levels in the low 10-12 for calcium and iodine, making the system well suited for these biomedical applications. Carbon blanks have been measured at low 10-16. For unattended, around-the-clock analysis, the system features the 200 sample version of the SO110 hybrid ion source and user friendly control software.

Experimental ball bearing dynamics study. [by high speed photography

NASA Technical Reports Server (NTRS)

Signer, H. R.

1973-01-01

A photographic method was employed to record the kinematic performance of rolling elements in turbo machinery ball bearings. The 110 mm split inner ring test bearings had nominal contact angles of 26 deg and 34 deg. High speed films were taken at inner ring speeds of 4,000, 8,000 and 12,000 rpm and at thrust loads of 4,448 N and 22,240 N (1,000 and 5,000 lbs). The films were measured and this data reduced to obtain separator speed, ball speed and ball spin axis orientation.

Report of the Secretary of Defense Caspar W. Weinberger to the Congress on the FY 1988/FY 1989 Budget and FY 1988-92 Defense Programs, January 12, 1987.

DTIC Science & Technology

1987-01-01

enough to sustain one wartime station overseas as well as satisfy training and maintenance needs. Advanced TacticalAir Reconnaissance System ( ATARS ...The ATARS is an umbrella concept for a series of upgrades in tactical reconnaissance capabilities. Major elements of the program include the Tactical...Funding Funding Funding E-3A Modifkation Development: $ Millions 105.2 96.8 110.7 88.4 Procurement: Quantity - - - - $ Millions .9 33.5 27.7 40.7 ATARS

Respirable antimony and other trace-elements inside and outside an elementary school in Flagstaff, AZ, USA.

PubMed

Majestic, Brian J; Turner, Joseph A; Marcotte, Aurelie R

2012-10-01

Because people spend almost 90% of their time indoors, ambient air monitors may severely underestimate actual exposure to atmospheric particulate matter (PM). Therefore, it becomes increasingly important to better understand the microenvironments where people are spending their time. For preadolescent children, the best estimates of exposure may be inside of their school. In this study, 11 size fractions of PM were collected inside and outside of an elementary school in Flagstaff, AZ, USA. In particles<1 μm (PM1), the total mass indoors was similar to the mass outdoors (indoor:outdoor, I:O, ratio=0.92 ± 0.16). In the PM1-10 fraction, however, the mass concentration inside the school was highly elevated relative to outside the school (I:O ratios=13 ± 3). Mass concentrations of 27 elements were analyzed by ICP-MS. For all metals except for antimony (Sb), the PM1 and PM1-10 I:O ratios are found to be similar to the overall PM mass (near 1 and 13, respectively). In addition, indoor and outdoor particle size distributions reveal a crustal character for every element except Cu, Zn, Pb, and Sb. Therefore, we hypothesize that most of the PM mass inside the school is a result of transport from outside the school followed by resuspension from floors and clothing. In the PM1 fraction, the indoor mass of Sb was 86 times greater than the outdoor mass and had an air concentration of 17 ngm(-3) - greater than many urban areas around the world. Cu:Sb ratios and size distribution functions suggest that the excess source of PM1 indoor Sb results from the suspension of embedded Sb (used as a flame retardant) in the carpeting. This is the first study to observe elevated submicron Sb in schools and further studies are required to determine if this is a widespread health risk. Copyright © 2012 Elsevier B.V. All rights reserved.

Comment on "A non-primitive origin of near-chondritic Ssbnd Sesbnd Te ratios in mantle peridotites: Implications for the Earth's late accretionary history" by König S. et al. [Earth Planet. Sci. Lett. 385 (2014) 110-121

NASA Astrophysics Data System (ADS)

Wang, Zaicong; Becker, Harry

2015-05-01

The abundances and ratios of S, Se and Te in rocks from the Earth's mantle may yield valuable constraints on the partitioning of these chalcophile elements between the mantle and basaltic magmas and on the compositions of these elements in the primitive mantle (PM) (e.g. Wang and Becker, 2013). Recently, König et al. (2014) proposed a model in which the CI chondrite-like Se/Te of mantle lherzolites (Se /Te = 8 ± 2, 1σ) are explained by mixing of sulfide melts with low Se/Te with harzburgites containing supposedly residual sulfides with high Se/Te. In this model sulfide melts and platinum group element (PGE) rich telluride phases with low Se/Te are assumed to have precipitated during refertilization of harzburgites by basic melts to form lherzolites. Because of the secondary nature of these re-enrichment processes, the authors state that abundances and ratios of S, Se and Te in fertile lherzolites cannot reflect the composition of the PM.

Simultaneous trace multielement determination by ICP-OES after solid phase extraction with modified octadecyl silica gel.

PubMed

Karbasi, Mohamad-Hadi; Jahanparast, Babak; Shamsipur, Mojtaba; Hassan, Jalal

2009-10-15

Multielement simultaneous determination of 35 trace elements in environmental samples was carried out by inductively coupled plasma emission spectrometry (ICP-OES) after preconcentration with octadecyl silicagel, modified with aurin tricarboxylic acid (Aluminon). Optimal experimental conditions including pH of sample solution, sample volume, sample and eluent flow rate, type, concentration and volume of eluent and foreign ions effect were investigated and established. Trace element ions in aqueous solution were quantitatively adsorbed onto octadecyl silicagel modified with aurin tricarboxylic acid at pH 8.0 with a flow rate of 11.0 mL min(-1). The adsorbed element ions were eluted with 3-5 mL of 0.5 mol L(-1) HNO(3) at a flow rate of 10.0 mL min(-1) and analyzed by ICP-OES simultaneously. The proposed method has at least preconcentration factor of 100 in water samples, which results high sensitive detection of ultra-trace and trace analysis. The present methodology gave recoveries better than 70% and RSD less than 16%.

Metal characterization of white hawthorn organs and infusions.

PubMed

Juranović Cindrić, Iva; Zeiner, Michaela; Konanov, Darija Mihajlov; Stingeder, Gerhard

2015-02-18

Hawthorn is one of the most commonly used European and North American phytopharmaceuticals. Because there is no information on metals in seeds, and only rare data for leaves and flowers, the aim of the present study was elemental analysis of the white hawthorn (Crataegus monogyna) by inductively coupled plasma emission spectrometry (ICP-AES) or inductively coupled plasma mass spectrometry (ICP-MS) after digestion in a microwave-assisted system. The limits of detection are below 2 μg/g for ICP-AES and 0.5 μg/g for ICP-MS. Hawthorn leaves and flowers contain essential elements at concentrations (mean values, RSD 2-8%) in mg/g of Ca, 1-4; K, 4-5; Mg, 1-2; and Na, <0.2); and at μg/g levels of Ba, 1-10; Co, <0.16; Cr, <1.4; Cu, 0.6-7; Fe, 1-37; Li, <0.5; Mn, 1-13; Mo, <0.17; Ni, <0.6; Sr, 0.2-2; and Zn, 1-31. Toxic elements were found in low quantities: As (<0.04), Cd (0.04-0.1), and Pb (0.1-2). Up to 10% of the metals is extracted into the infusions. The analyzed plant parts and infusions contain essential elements justifying its use as a medicinal plant, whereas the low quantities of harmful elements will not pose any risk to humans when consumed.

ORBITAL SOLUTIONS AND ABSOLUTE ELEMENTS OF THE ECLIPSING BINARY EE AQUARII

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wronka, Marissa Diehl; Gold, Caitlin; Sowell, James R.

2010-04-15

EE Aqr is a 7.9 mag Algol variable with a 12 hr orbital period. The Wilson-Devinney program is used to simultaneously solve 11 previously published light curves together with two existing radial velocity curves. The resulting masses are M {sub 1} = 2.24 {+-} 0.13 M {sub sun} and M {sub 2} = 0.72 {+-} 0.04 M {sub sun}, and the radii are R {sub 1} = 1.76 {+-} 0.03 R {sub sun} and R {sub 2} = 1.10 {+-} 0.02 R {sub sun}. The system has the lower-mass component completely filling its Roche lobe. Its distance from Hipparcos observationsmore » is 112 {+-} 10 pc. An improved ephemeris is derived, and no deviations in the period over time were seen. Light and velocity curve parameters, orbital elements, and absolute dimensions are presented, plus a comparison is made with previous solutions.« less

Neutral atoms facility for space sensors characterization and BepiColombo/ELENA development instrument's progresses.

NASA Astrophysics Data System (ADS)

de Angelis, E.; di Lellis, A. M.; Orsini, S.; Zanza, V.; Maggi, M.; Vertolli, N.; D'Amicis, R.; Tilia, B.; Sibio, A.

2003-04-01

An Energetic Neutral Atoms facility to test and calibrate Neutral Atoms Analyzers has been developed in the Scientific Technical Unit of Fusion at the ENEA Research Center in Frascati (Rome-Italy). In the last years a collaboration with IFSI (Interplanetary Space and Physics Institute, CNR-Rome-Italy) has allowed to use this facility for space sensors and for characterization of crucial instruments elements. The ENA beam is realized with an ion source and a neutralization cell, and allows to test any instrument in the energy range 300eV-110keV with the available masses of Hydrogen, Deuterium or Helium. At the moment, the critical elements of ELENA (Emitted Low Energy Neutral Atoms) instrument proposed for BepiColombo ESA cornerstone mission to Mercury is under development testing. The facility, its potentiality and the instrument characterization progresses are presented.

Search for Majorana Neutrinos Near the Inverted Mass Hierarchy Region with KamLAND-Zen.

PubMed

Gando, A; Gando, Y; Hachiya, T; Hayashi, A; Hayashida, S; Ikeda, H; Inoue, K; Ishidoshiro, K; Karino, Y; Koga, M; Matsuda, S; Mitsui, T; Nakamura, K; Obara, S; Oura, T; Ozaki, H; Shimizu, I; Shirahata, Y; Shirai, J; Suzuki, A; Takai, T; Tamae, K; Teraoka, Y; Ueshima, K; Watanabe, H; Kozlov, A; Takemoto, Y; Yoshida, S; Fushimi, K; Banks, T I; Berger, B E; Fujikawa, B K; O'Donnell, T; Winslow, L A; Efremenko, Y; Karwowski, H J; Markoff, D M; Tornow, W; Detwiler, J A; Enomoto, S; Decowski, M P

2016-08-19

We present an improved search for neutrinoless double-beta (0νββ) decay of ^{136}Xe in the KamLAND-Zen experiment. Owing to purification of the xenon-loaded liquid scintillator, we achieved a significant reduction of the ^{110m}Ag contaminant identified in previous searches. Combining the results from the first and second phase, we obtain a lower limit for the 0νββ decay half-life of T_{1/2}^{0ν}>1.07×10^{26}  yr at 90% C.L., an almost sixfold improvement over previous limits. Using commonly adopted nuclear matrix element calculations, the corresponding upper limits on the effective Majorana neutrino mass are in the range 61-165 meV. For the most optimistic nuclear matrix elements, this limit reaches the bottom of the quasidegenerate neutrino mass region.

Impact of impedance unbalance on the efficiency of electricity transmission and distribution - A case study

NASA Astrophysics Data System (ADS)

Pavlov, L'uboš; Skurčák, L'uboš; Chovanec, Juraj; Altus, Juraj

2017-11-01

This article is devoted to the analysis of the possible influence of impedance asymmetry on the efficiency of electricity transmission and distribution in the electricity system in Slovakia, at a voltage level of 110 kV - 400 kV, using synchronic phasor monitoring results. For simplicity of calculations, in practice, the impedance imbalance from mutual interfacial inductive capacitances bonds is neglected. In this way, the 3-phase network is interpreted as symmetrical in the calculations. In this case, it is possible to determine only some components of losses (ohmic losses, corona loss, leakages, etc). The influence of impedance asymmetry can be quantified by calculation using the results of the monitoring of the synchronous phasors of selected electricity system elements (OHL, transformer, choke) or by 3-phase modelling of real system elements. frequency to test the transformer for induced over voltage test, and its characteristics is analysed.

Search for Majorana Neutrinos Near the Inverted Mass Hierarchy Region with KamLAND-Zen

DOE PAGES

Gando, A.; Gando, Y.; Hachiya, T.; ...

2016-08-16

Here, we present an improved search for neutrinoless double-beta (0νββ) decay of Xe 136 in the KamLAND-Zen experiment. Owing to purification of the xenon-loaded liquid scintillator, we achieved a significant reduction of the Ag 110m contaminant identified in previous searches. Combining the results from the first and second phase, we obtain a lower limit for the 0νββ decay half-life of Tmore » $$0v\\atop{1/2}$$ > 1.07×10 26 yr at 90% C.L., an almost sixfold improvement over previous limits. Using commonly adopted nuclear matrix element calculations, the corresponding upper limits on the effective Majorana neutrino mass are in the range 61-165 meV. Finally, for the most optimistic nuclear matrix elements, this limit reaches the bottom of the quasidegenerate neutrino mass region.« less

Development of high flux thermal neutron generator for neutron activation analysis

NASA Astrophysics Data System (ADS)

Vainionpaa, Jaakko H.; Chen, Allan X.; Piestrup, Melvin A.; Gary, Charles K.; Jones, Glenn; Pantell, Richard H.

2015-05-01

The new model DD110MB neutron generator from Adelphi Technology produces thermal (<0.5 eV) neutron flux that is normally achieved in a nuclear reactor or larger accelerator based systems. Thermal neutron fluxes of 3-5 · 107 n/cm2/s are measured. This flux is achieved using four ion beams arranged concentrically around a target chamber containing a compact moderator with a central sample cylinder. Fast neutron yield of ∼2 · 1010 n/s is created at the titanium surface of the target chamber. The thickness and material of the moderator is selected to maximize the thermal neutron flux at the center. The 2.5 MeV neutrons are quickly thermalized to energies below 0.5 eV and concentrated at the sample cylinder. The maximum flux of thermal neutrons at the target is achieved when approximately half of the neutrons at the sample area are thermalized. In this paper we present simulation results used to characterize performance of the neutron generator. The neutron flux can be used for neutron activation analysis (NAA) prompt gamma neutron activation analysis (PGNAA) for determining the concentrations of elements in many materials. Another envisioned use of the generator is production of radioactive isotopes. DD110MB is small enough for modest-sized laboratories and universities. Compared to nuclear reactors the DD110MB produces comparable thermal flux but provides reduced administrative and safety requirements and it can be run in pulsed mode, which is beneficial in many neutron activation techniques.

Oxides for sustainable photovoltaics with earth-abundant materials

NASA Astrophysics Data System (ADS)

Wagner, Alexander; Stahl, Mathieu; Ehrhardt, Nikolai; Fahl, Andreas; Ledig, Johannes; Waag, Andreas; Bakin, Andrey

2014-03-01

Energy conversion technologies are aiming to extremely high power capacities per year. Nontoxicity and abundance of the materials are the key requirements to a sustainable photovoltaic technology. Oxides are among the key materials to reach these goals. We investigate the influence of thin buffer layers on the performance of an ZnO:Al/buffer/Cu2O solar cells. Introduction of a thin ZnO or Al2O3 buffer layer, grown by thermal ALD, between ZnO:Al and Cu2O resulted in 45% increase of the solar cell efficiency. VPE growth of Cu2O employing elemental copper and pure oxygen as precursor materials is presented. The growth is performed on MgO substrates with the (001) orientation. On- and off- oriented substrates have been employed and the growth results are compared. XRD investigations show the growth of the (110) oriented Cu2O for all temperatures, whereas at a high substrate temperature additional (001) Cu2O growth occurs. An increase of the oxygen partial pressure leads to a more pronounced 2D growth mode, whereby pores between the islands still remain. The implementation of off-axis substrates with 3.5° and 5° does not lead to an improvement of the layer quality. The (110) orientation remains predominant, the grain size decreases and the FWHM of the (220) peak increases. From the AFM images it is concluded, that the (110) surface grows with a tilt angle to the substrate surface.

Ab initio molecular dynamics simulations of low energy recoil events in MgO

NASA Astrophysics Data System (ADS)

Petersen, B. A.; Liu, B.; Weber, W. J.; Zhang, Y.

2017-04-01

Low-energy recoil events in MgO are studied using ab intio molecular dynamics simulations to reveal the dynamic displacement processes and final defect configurations. Threshold displacement energies, Ed, are obtained for Mg and O along three low-index crystallographic directions, [100], [110], and [111]. The minimum values for Ed are found along the [110] direction consisting of the same element, either Mg or O atoms. Minimum threshold values of 29.5 eV for Mg and 25.5 eV for O, respectively, are suggested from the calculations. For other directions, the threshold energies are considerably higher, 65.5 and 150.0 eV for O along [111] and [100], and 122.5 eV for Mg along both [111] and [100] directions, respectively. These results show that the recoil events in MgO are partial-charge transfer assisted processes where the charge transfer plays an important role. There is a similar trend found in other oxide materials, where the threshold displacement energy correlates linearly with the peak partial-charge transfer, suggesting this behavior might be universal in ceramic oxides.

Synthesis, structural characterization and dielectric behavior of new oxime-cyclotriphosphazene derivatives

NASA Astrophysics Data System (ADS)

Koran, Kenan; Özen, Furkan; Biryan, Fatih; Görgülü, Ahmet Orhan

2016-02-01

The cyclotriphosphazene compound (2) bearing formyl groups as side groups was obtained from the reaction of 2,2-Dichloro-4,4,6,6-bis[spiro(2‧,2″-dioxy-1‧,1″-biphenylyl)]cyclotriphosphazene (1) with 4-hydroxy-3-methoxybenzaldehyde in the presence K2CO3 in tetrahydrofuran. Oxime-cyclotriphosphazene compound (3) was synthesized from the reaction of compound 2 with hydroxylamine hydrochloride in pyridine. The synthesized oxime-phosphazene compound (3) was reacted with alkyl and acyl halides. As a results, the cyclotriphosphazene compounds (1-10) bearing oxime ether and ester as side groups were obtained. The chemical structures of these compounds (1-10) were determined by elemental analysis, FT-IR, 1H, 13C and 31P NMR spectroscopic methods. Dielectric constant, dielectric loss factors and conductivity properties of cyclotriphosphazene compounds were measured over the frequency range from 100 Hz to 2 kHz at 25 °C and compared with each other. It is found that ester substituted cyclotriphosphazenes have higher dielectric constant. Our study suggests that these phosphazenes promising candidate materials in multifunctional optoelectronic devices.

Two novel copper(II) complexes constructed from dicarboxylate ligands with different spacer lengths and 2-phenylimidazo[4,5- f]1,10-phenanthroline (PIP): Synthesis, structures and properties

NASA Astrophysics Data System (ADS)

Wang, X.-L.; Chen, Yongqiang; Liu, Guocheng; Lin, Hongyan; Zhang, Jinxia

2009-09-01

Two novel metal-organic coordination polymers [Cu(PIP)(bpea)(H 2O)]·H 2O ( 1) and [Cu(PIP)(1,4-bdc)] ( 2) have been obtained from hydrothermal reaction of copper(II) with the mixed ligands [biphenylethene-4,4'-dicarboxylic acid (bpea) for 1, benzene-1,4-dicarboxylic acid (1,4-H 2bdc) for 2, and 2-phenylimidazo[4,5- f]1,10-phenanthroline (PIP)]. Both complexes have been structurally characterized by elemental analyses, IR and single-crystal X-ray diffraction analyses. Structural analyses reveal that complex 1 possesses infinite one-dimensional zigzag chain, 2 exhibits a two-dimensional (4,4) network, both of which are extended into three-dimensional supramolecular network by weak interactions. The different structures of the title complexes illustrate the influence of the flexibility (the spacer length of carboxyl groups and the structural rigidity of the spacer) of organic dicarboxylate ligands on the formation of such coordination architectures. Moreover, the thermal properties and the voltammetric behavior of complexes 1 and 2 have been reported.

One Step Synthesis of NiO Nanoparticles via Solid-State Thermal Decomposition at Low-Temperature of Novel Aqua(2,9-dimethyl-1,10-phenanthroline)NiCl2 Complex

PubMed Central

Barakat, Assem; Al-Noaimi, Mousa; Suleiman, Mohammed; Aldwayyan, Abdullah S.; Hammouti, Belkheir; Ben Hadda, Taibi; Haddad, Salim F.; Boshaala, Ahmed; Warad, Ismail

2013-01-01

[NiCl2(C14H12N2)(H2O)] complex has been synthesized from nickel chloride hexahydrate (NiCl2·6H2O) and 2,9-dimethyl-1,10-phenanthroline (dmphen) as N,N-bidentate ligand. The synthesized complex was characterized by elemental analysis, infrared (IR) spectroscopy, ultraviolet-visible (UV-vis) spectroscopy and differential thermal/thermogravimetric analysis (TG/DTA). The complex was further confirmed by single crystal X-ray diffraction (XRD) as triclinic with space group P-1. The desired complex, subjected to thermal decomposition at low temperature of 400 ºC in an open atmosphere, revealed a novel and facile synthesis of pure NiO nanoparticles with uniform spherical particle; the structure of the NiO nanoparticles product was elucidated on the basis of Fourier transform infrared (FT-IR), UV-vis spectroscopy, TG/DTA, XRD, scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDXS) and transmission electron microscopy (TEM). PMID:24351867

Origin discrimination of defatted pork via trace elements profiling, stable isotope ratios analysis, and multivariate statistical techniques.

PubMed

Park, Yu Min; Lee, Cheong Mi; Hong, Joon Ho; Jamila, Nargis; Khan, Naeem; Jung, Jong-Hyun; Jung, Young-Chul; Kim, Kyong Su

2018-09-01

This study verified the origin of 346 defatted Korean and non-Korean pork samples via trace elements profiling, and C and N stable isotope ratios analysis. The analyzed elements were 6 Li, 7 Li, 10 B, 11 B, 51 V , 50 Cr, 52 Cr, 53 Cr, 55 Mn, 58 Ni, 60 Ni, 59 Co, 63 Cu, 65 Cu, 64 Zn, 66 Zn, 69 Ga, 71 Ga, 75 As, 82 Se, 84 Sr, 86 Sr, 87 Sr, 88 Sr, 85 Rb, 94 Mo, 95 Mo, 97 Mo, 107 Ag, 109 Ag, 110 Cd, 111 Cd, 113 Cd, 112 Cd, 114 Cd, 116 Cd, 133 Cs, 206 Pb, 207 Pb, and 208 Pb. Content (mg/kg) of 51 V (0.012), 50 Cr (0.882), 75 As (0.017), 85 Rb (57.7), and 87 Sr (46.3) were high in Korean pork samples whereas 6 Li, 7 Li, 59 Co, 55 Mn, 58 Ni, 84 Sr, 86 Sr, 88 Sr, 111 Cd, and 133 Cs were found higher in non-Korean samples. The results of discriminant analysis showed that the trace elements content and stable isotope ratios were significant for the discrimination of geographical origins with a perfect discrimination rate of 100%. Copyright © 2018 Elsevier Ltd. All rights reserved.

The Effects of Surface Roughness on the NEAR XRS Elemental Results: Monte-Carlo Modeling

NASA Technical Reports Server (NTRS)

Lin, Lucy F.; Nittler, Larry R.

2011-01-01

The objective of the NEAR-Shoemaker X-ray Gamma-Ray Spec1roscopy ("XGRS") investigation was to determine the elemental composition of the near-Earth asteroid 433 Eros. The X-ray Spectrometer (XRS) system measured the characteristic fluorescence of six major elements (Mg, Al, Si, S, Ca, Fe) in the 1-10 keV energy range excited by the interaction of solar X-rays with the upper 100 microns of the surface of 433 Eros. Various investigators, using both laboratory experiments and computer simulations have established that X-ray fluorescent line ratios can be influenced by small-scale surface roughness at high incidence or emission angles. The effect on the line ratio is specific to the geometry, excitation spectrum, and composition involved, In general, however, the effect is only substantial for ratios of lines with a significant energy difference between them: Fe/Si and Ca/Si are much more likely to be affected than AI/Si or Mg/Si. We apply a Monte-Carlo code to the specific geometry and spectrum of a major NEAR XRS solar flare observation, using an H chondrite composition as the substrate. The seventeen most abundant elements were included in the composition model, from oxygen to titanium.

Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS.

PubMed

Heitland, Peter; Köster, Helmut D

2006-01-01

The trace elements Ag, As, Au, B, Ba, Be, Bi, Cd, Ce, Co, Cs, Cu, Ga, Hf, Hg, In, La, Mn, Mo, Ni, Pb, Pd, Rb, Rh, Ru, Sb, Se, Sn, Sr, Te, Th, Tl, U, V, W, Y and Zr were determined in 130 human blood samples from occupationally non-exposed volunteers living in the greater area of Bremen in northern Germany. The blood samples were collected in lithium heparin monovettes developed for trace metal determination and were analysed by inductively coupled plasma mass spectrometry (ICP-MS) with an octopole-based collision/reaction cell. For sample introduction into the ICP, the blood samples were diluted 1/10 (V/V) with a 0.1% Triton-X-100 and 0.5% (V/V) ammonia solution. The method validation of our developed routine method is described for all 37 elements and results about internal and external quality assurance are discussed. Information on exposure conditions of all human subjects were collected by questionnaire-based interviews, including smoking habits, seafood consumption and the type of dental alloys in the teeth. Mean values, geometric mean values, ranges and selected percentiles of all elemental concentrations in human blood are presented, which helps toxicologists and clinical chemists planning research about exposition to metals and health effects caused by exposition to metals.

The 1ST Battalion 7TH Infantry in the Gulf War

DTIC Science & Technology

1993-03-23

TAB Urnarnol:necd 0 Jusltifcollur) By_ Avjilbihity Codes Dist SpecialI 1V v\\ l tdqO ABSTRACT AUTHOR: Stephen S. Smith, LTC(P), USA TITLE: The Ist...the base element for the movement of the entire brigade. Our C Co, under the command of Cpt Tracy Cleaver, had the responsibility for guiding our...under the sand because of the heavy rains. 32 AN~ f4SM;VI9A AAAO%~ TOT A L S W%-TO R :ý 300 K 110 K AA To SPot: 9 OW ~001 1AL -UI-. Afte Actio Review 10

Coherent Detector Arrays for Continuum and Spectral Line Applications

NASA Technical Reports Server (NTRS)

Gaier, Todd C.

2006-01-01

This viewgraph presentation reviews the requirements for improved coherent detector arrays for use in continuum and spectral line applications. With detectors approaching fundamental limits, large arrays offer the only path to sensitivity improvement. Monolithic Microwave Integrated Circuit (MMIC) technology offers a straightforward path to massive focal plane millimeter wave arrays: The technology will readily support continuum imagers, polarimeters and spectral line receivers from 30-110 GHz. Science programs, particularly large field blind surveys will benefit from simultaneous observations of hundreds or thousands of pixels 1000 element array is competitive with a cost less than $2M.

Energy investigation of effects of O on mechanical properties of NiAl intermetallics.

PubMed

Hu, Xue-Lan; Liu, Li-Hua; Zhang, Ying; Lu, Guang-Hong; Wang, Tianmin

2011-01-19

We have investigated effects of O on mechanical properties of NiAl by calculating the cleavage energy (γ(C)) and the unstable stacking fault energy (γ(us)) using a first-principles method. O is shown to reduce γ(C)/γ(us) for the [001](110) and [100](001) slip systems, indicating that the presence of O should be associated with the ductility reduction of NiAl. Further, γ(C)/γ(us) of the NiAl-O system can be increased by Cr, suggesting the possibility to suppress the negative effect of O via alloying elements.

US Army Corps of Engineers Reconnaissance Report: North Coast of Honduras Flooding,

DTIC Science & Technology

1988-03-01

1,000 ’ Study Element O Sector Two Sector Six Coordination (Other Agencies, etc) $ 60 $ 40 $ 50 Institutional/Financial 30 10 30 " Agricultural...Socioeconnic 100 180 150 Hydrologic 80 130 110 Hydraulic 170 260 200 Geotechnical 130 100 90 , Structural 80 50 70 Cost Estimating 20 30 40 Surveys and...77- cc CC Ar 0~ , - .1i cr* 6 *1*, ~..tic V𔃾t ’ e-4 rN. I- - B-10 ona- 20 T. n 10 7- tl o l I 40 - 30 - ~.ll 1 r- r. Fig B-" MEA MOTL

KSC-2009-5920

NASA Image and Video Library

2009-10-27

CAPE CANAVERAL, Fla. - At the weather station on Cape Canaveral Air Force Station in Florida, a meteorological data specialist prepares to release a low resolution flight element rawinsonde to support the countdown for the flight test of NASA's Ares I-X rocket. A GPS-tracked weather balloon, a rawinsonde has a tethered instrument package which radios its altitude to the ground along with atmospheric data such as temperature, dewpoint and humidity, and wind speed and direction. Rawinsondes can reach altitudes up to 110,000 feet. For information on the Ares I-X vehicle and flight test, visit http://www.nasa.gov/aresIX. Photo credit: NASA/Jack Pfaller

KSC-2009-5921

NASA Image and Video Library

2009-10-27

CAPE CANAVERAL, Fla. - At the weather station on Cape Canaveral Air Force Station in Florida, a meteorological data specialist releases a low resolution flight element rawinsonde to support the countdown for the flight test of NASA's Ares I-X rocket. A GPS-tracked weather balloon, a rawinsonde has a tethered instrument package which radios its altitude to the ground along with atmospheric data such as temperature, dewpoint and humidity, and wind speed and direction. Rawinsondes can reach altitudes up to 110,000 feet. For information on the Ares I-X vehicle and flight test, visit http://www.nasa.gov/aresIX. Photo credit: NASA/Jack Pfaller

KSC-2009-5919

NASA Image and Video Library

2009-10-27

CAPE CANAVERAL, Fla. - In the weather station on Cape Canaveral Air Force Station in Florida, a meteorological data specialist prepares a low resolution flight element rawinsonde to support the countdown for the flight test of NASA's Ares I-X rocket. A GPS-tracked weather balloon, a rawinsonde has a tethered instrument package which radios its altitude to the ground along with atmospheric data such as temperature, dewpoint and humidity, and wind speed and direction. Rawinsondes can reach altitudes up to 110,000 feet. For information on the Ares I-X vehicle and flight test, visit http://www.nasa.gov/aresIX. Photo credit: NASA/Jack Pfaller

KSC-2009-5918

NASA Image and Video Library

2009-10-27

CAPE CANAVERAL, Fla. - In the weather station on Cape Canaveral Air Force Station in Florida, meteorological data specialists prepare two low resolution flight element rawinsonde to support the countdown for the flight test of NASA's Ares I-X rocket. A GPS-tracked weather balloon, a rawinsonde has a tethered instrument package which radios its altitude to the ground along with atmospheric data such as temperature, dewpoint and humidity, and wind speed and direction. Rawinsondes can reach altitudes up to 110,000 feet. For information on the Ares I-X vehicle and flight test, visit http://www.nasa.gov/aresIX. Photo credit: NASA/Jack Pfaller

[Determination of multi-element contents in gypsum by ICP-AES].

PubMed

Guo, Zhong-bao; Bai, Yong-zhi; Cui, Jin-hua; Mei, Yi-fei; Ma, Zhen-zhu

2014-08-01

The content of multi-element in gypsum was determined by ICP-AES. The sample was pretreated by acid-soluble method or alkali-fusion method. Acid-soluble method is suitable for the determination of CaO, SOs, Al2O3, Fe2O3, MgO, K2O, Na2O, TiO2, P2O5, MnO, SrO and BaO. Alkali-fusion method is suitable for the determination of CaO, SO3, SiO2, Al2O3, Fe2O3, MgO, TiO2, P2O5, MnO, SrO, BaO and B2O3. Different series standard solutions were prepared considering the properties and content of elements and solution matrix. The limit of detection and quantification were confirmed for each element under their best analysis spectral lines. The recoveries of the two pretreatment methods were from 93% to 110%, besides that for TiO2 was 81%-87% as pretreated by acid-soluble method. All RSDs (n=6) of tests were from 0.70%-3.42%. The accuracies of CaO and SO3 with ICP-AES method were less than the chemical analysis method. The determination of CaO and SO3 with ICP-AES method is only suitable for the case of low accuracy requirement. The results showed that the method can be used for the determination of multi-element contents in gypsum, with simple operation, fast analysis and reliable results. Total elements can be analysed with both acid-soluble method and alkali-fusion method.

[A finite element analysis of petal-shaped poly-axial locking plate fixation in treatment of Y-shaped patellar fracture].

PubMed

Meng, Depeng; Ouyang, Yueping; Hou, Chunlin

2017-12-01

To establish the finite element model of Y-shaped patellar fracture fixed with titanium-alloy petal-shaped poly-axial locking plate and to implement the finite element mechanical analysis. The three-dimensional model was created by software Mimics 19.0, Rhino 5.0, and 3-Matic 11.0. The finite element analysis was implemented by ANSYS Workbench 16.0 to calculate the Von-Mises stress and displacement. Before calculated, the upper and lower poles of the patella were constrained. The 2.0, 3.5, and 4.4 MPa compressive stresses were applied to the 1/3 patellofemoral joint surface of the lower, middle, and upper part of the patella respectively, and to simulated the force upon patella when knee flexion of 20, 45, and 90°. The number of nodes and elements of the finite element model obtained was 456 839 and 245 449, respectively. The max value of Von-Mises stress of all the three conditions simulated was 151.48 MPa under condition simulating the knee flexion of 90°, which was lower than the yield strength value of the titanium-alloy and patella. The max total displacement value was 0.092 8 mm under condition simulating knee flexion of 45°, which was acceptable according to clinical criterion. The stress concentrated around the non-vertical fracture line and near the area where the screws were sparse. The titanium-alloy petal-shaped poly-axial locking plate have enough biomechanical stiffness to fix the Y-shaped patellar fracture, but the result need to be proved in future.

10 CFR 110.110 - Default.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Default. 110.110 Section 110.110 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Hearings § 110.110 Default. When a participant fails to act within a specified time, the presiding officer may consider him in default, issue an...

Compositional variations at ultra-structure length scales in coral skeleton

NASA Astrophysics Data System (ADS)

Meibom, Anders; Cuif, Jean-Pierre; Houlbreque, Fanny; Mostefaoui, Smail; Dauphin, Yannicke; Meibom, Karin L.; Dunbar, Robert

2008-03-01

Distributions of Mg and Sr in the skeletons of a deep-sea coral ( Caryophyllia ambrosia) and a shallow-water, reef-building coral ( Pavona clavus) have been obtained with a spatial resolution of 150 nm, using the NanoSIMS ion microprobe at the Muséum National d'Histoire Naturelle in Paris. These trace element analyses focus on the two primary ultra-structural components in the skeleton: centers of calcification (COC) and fibrous aragonite. In fibrous aragonite, the trace element variations are typically on the order of 10% or more, on length scales on the order of 1-10 μm. Sr/Ca and Mg/Ca variations are not correlated. However, Mg/Ca variations in Pavona are strongly correlated with the layered organization of the skeleton. These data allow for a direct comparison of trace element variations in zooxanthellate and non-zooxanthellate corals. In both corals, all trace elements show variations far beyond what can be attributed to variations in the marine environment. Furthermore, the observed trace element variations in the fibrous (bulk) part of the skeletons are not related to the activity of zooxanthellae, but result from other biological activity in the coral organism. To a large degree, this biological forcing is independent of the ambient marine environment, which is essentially constant on the growth timescales considered here. Finally, we discuss the possible detection of a new high-Mg calcium carbonate phase, which appears to be present in both deep-sea and reef-building corals and is neither aragonite nor calcite.

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

PubMed

Guillermet-Guibert, Julie; Bjorklof, Katja; Salpekar, Ashreena; Gonella, Cristiano; Ramadani, Faruk; Bilancio, Antonio; Meek, Stephen; Smith, Andrew J H; Okkenhaug, Klaus; Vanhaesebroeck, Bart

2008-06-17

The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110alpha, p110beta, and p110delta) occur in complex with a Src homology 2 (SH2) domain-containing p85 regulatory subunit, which has been shown to link p110alpha and p110delta to Tyr kinase signaling pathways. The p84/p101 regulatory subunits of the p110gamma class IB PI3K lack SH2 domains and instead couple p110gamma to G protein-coupled receptors (GPCRs). Here, we show, using small-molecule inhibitors with selectivity for p110beta and cells derived from a p110beta-deficient mouse line, that p110beta is not a major effector of Tyr kinase signaling but couples to GPCRs. In macrophages, both p110beta and p110gamma contributed to Akt activation induced by the GPCR agonist complement 5a, but not by the Tyr kinase ligand colony-stimulating factor-1. In fibroblasts, which express p110beta but not p110gamma, p110beta mediated Akt activation by the GPCR ligands stromal cell-derived factor, sphingosine-1-phosphate, and lysophosphatidic acid but not by the Tyr kinase ligands PDGF, insulin, and insulin-like growth factor 1. Introduction of p110gamma in these cells reduced the contribution of p110beta to GPCR signaling. Taken together, these data show that p110beta and p110gamma can couple redundantly to the same GPCR agonists. p110beta, which shows a much broader tissue distribution than the leukocyte-restricted p110gamma, could thus provide a conduit for GPCR-linked PI3K signaling in the many cell types where p110gamma expression is low or absent.

The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ

PubMed Central

Guillermet-Guibert, Julie; Bjorklof, Katja; Salpekar, Ashreena; Gonella, Cristiano; Ramadani, Faruk; Bilancio, Antonio; Meek, Stephen; Smith, Andrew J. H.; Okkenhaug, Klaus; Vanhaesebroeck, Bart

2008-01-01

The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and p110δ) occur in complex with a Src homology 2 (SH2) domain-containing p85 regulatory subunit, which has been shown to link p110α and p110δ to Tyr kinase signaling pathways. The p84/p101 regulatory subunits of the p110γ class IB PI3K lack SH2 domains and instead couple p110γ to G protein-coupled receptors (GPCRs). Here, we show, using small-molecule inhibitors with selectivity for p110β and cells derived from a p110β-deficient mouse line, that p110β is not a major effector of Tyr kinase signaling but couples to GPCRs. In macrophages, both p110β and p110γ contributed to Akt activation induced by the GPCR agonist complement 5a, but not by the Tyr kinase ligand colony-stimulating factor-1. In fibroblasts, which express p110β but not p110γ, p110β mediated Akt activation by the GPCR ligands stromal cell-derived factor, sphingosine-1-phosphate, and lysophosphatidic acid but not by the Tyr kinase ligands PDGF, insulin, and insulin-like growth factor 1. Introduction of p110γ in these cells reduced the contribution of p110β to GPCR signaling. Taken together, these data show that p110β and p110γ can couple redundantly to the same GPCR agonists. p110β, which shows a much broader tissue distribution than the leukocyte-restricted p110γ, could thus provide a conduit for GPCR-linked PI3K signaling in the many cell types where p110γ expression is low or absent. PMID:18544649

Characteristics of trace metals in traffic-derived particles in Hsuehshan Tunnel, Taiwan: size distribution, fingerprinting metal ratio, and emission factor

NASA Astrophysics Data System (ADS)

Lin, Y.-C.; Tsai, C.-J.; Wu, Y.-C.; Zhang, R.; Chi, K.-H.; Huang, Y.-T.; Lin, S.-H.; Hsu, S.-C.

2014-05-01

Traffic emissions are a significant source of airborne particulate matter (PM) in ambient environments. These emissions contain high abundance of toxic metals and thus pose adverse effects on human health. Size-fractionated aerosol samples were collected from May to September 2013 by using micro-orifice uniform deposited impactor (MOUDI). Sample collection was conducted simultaneously at the inlet and outlet sites of Hsuehshan Tunnel in northern Taiwan, which is the second longest freeway tunnel (12.9 km) in Asia. Such endeavor aims to characterize the chemical constituents, size distributions, and fingerprinting ratios, as well as the emission factors of particulate metals emitted by vehicle fleets. A total of 36 metals in size-resolved aerosols were determined through inductively coupled plasma mass spectrometry. Three major groups, namely, tailpipe emissions (Zn, Pb, and V), wear debris (Cu, Cd, Fe, Ga, Mn, Mo, Sb, and Sn), and resuspended dust (Ca, Mg, K, and Rb), of airborne PM metals were categorized on the basis of the results of enrichment factor, correlation matrix, and principal component analysis. Size distributions of wear-originated metals resembled the pattern of crustal elements, which were predominated by super-micron particulates (PM1-10). By contrast, tailpipe exhaust elements such as Zn, Pb, and V were distributed mainly in submicron particles. By employing Cu as a tracer of wear abrasion, several inter-metal ratios, including Fe/Cu (14), Ba/Cu (1.05), Sb/Cu (0.16), Sn/Cu (0.10), and Ga/Cu (0.03), served as fingerprints for wear debris. Emission factor of PM10 mass was estimated to be 7.7 mg vkm-1. The metal emissions were mostly predominated in super-micron particles (PM1-10). Finally, factors that possibly affect particulate metal emissions inside Hsuehshan Tunnel are discussed.

ELECTRON PROBE MICROANALYSIS OF IRRADIATED AND 1600°C SAFETY-TESTED AGR-1 TRISO FUEL PARTICLES WITH LOW AND HIGH RETAINED 110MAG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, Karen E.; van Rooyen, Isabella J.

2016-11-01

AGR-1 fuel Compact 4-3-3 achieved 18.63% FIMA and was exposed subsequently to a safety test at 1600°C. Two particles, AGR1-433-003 and AGR1-433-007, with measured-to-calculated 110mAg inventories of <22% and 100%, respectively, were selected for comparative electron microprobe analysis to determine whether the distribution or abundance of fission products differed proximally and distally from the deformed kernel in AGR1-433-003, and how this compared to fission product distribution in AGR1-433-007. On the deformed side of AGR1-433-003, Xe, Cs, I, Eu, Sr, and Te concentrations in the kernel buffer interface near the protruded kernel were up to six times higher than on themore » opposite, non-deformed side. At the SiC-inner pyrolytic carbon (IPyC) interface proximal to the deformed kernel, Pd and Ag concentrations were 1.2 wt% and 0.04 wt% respectively, whereas on the SiC-IPyC interface distal from the kernel deformation those elements measured 0.4 and 0.01 wt%, respectively. Palladium and Ag concentrations at the SiC-IPyC interface of AGR1-433-007 were 2.05 and 0.05 wt.%, respectively. Rare earth element concentrations at the SiC-IPyC interface of AGR1-433-007 were a factor of ten higher than at the SiC-IPyC interfaces measured in particle AGR1-433-003. Palladium permeated the SiC layer of AGR1-433-007 and the non-deformed SiC layer of AGR1-433-003.« less

Determination of essential elements in beverages, herbal infusions and dietary supplements using a new straightforward sequential approach based on flame atomic absorption spectrometry.

PubMed

Gómez-Nieto, Beatriz; Gismera, Mª Jesús; Sevilla, Mª Teresa; Procopio, Jesús R

2017-03-15

A simple method based on FAAS was developed for the sequential multi-element determination of Cu, Zn, Mn, Mg and Si in beverages and food supplements with successful results. The main absorption lines for Cu, Zn and Si and secondary lines for Mn and Mg were selected to carry out the measurements. The sample introduction was performed using a flow injection system. Using the choice of the absorption line wings, the upper limit of the linear range increased up to 110mgL -1 for Mg, 200mgL -1 for Si and 13mgL -1 for Zn. The determination of the five elements was carried out, in triplicate, without the need of additional sample dilutions and/or re-measurements, using less than 3.5mL of sample to perform the complete analysis. The LODs were 0.008mgL -1 for Cu, 0.017mgL -1 for Zn, 0.011mgL -1 for Mn, 0.16mgL -1 for Si and 0.11mgL -1 for Mg. Copyright © 2016 Elsevier Ltd. All rights reserved.

Metal insulator transitions in perovskite SrIrO{sub 3} thin films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biswas, Abhijit; Jeong, Yoon Hee, E-mail: yhj@postech.ac.kr; Kim, Ki-Seok

Understanding of metal insulator transitions in a strongly correlated system, driven by Anderson localization (disorder) and/or Mott localization (correlation), is a long standing problem in condensed matter physics. The prevailing fundamental question would be how these two mechanisms contrive to accomplish emergent anomalous behaviors. Here, we have grown high quality perovskite SrIrO{sub 3} thin films, containing a strong spin orbit coupled 5d element Ir, on various substrates such as GdScO{sub 3} (110), DyScO{sub 3} (110), SrTiO{sub 3} (001), and NdGaO{sub 3} (110) with increasing lattice mismatch, in order to carry out a systematic study on the transport properties. We foundmore » that metal insulator transitions can be induced in this system; by either reducing thickness (on best lattice matched substrate) or changing degree of lattice strain (by lattice mismatch between film and substrates) of films. Surprisingly these two pathways seek two distinct types of metal insulator transitions; the former falls into disorder driven Anderson type whereas the latter turns out to be of unconventional Mott-Anderson type with the interplay of disorder and correlation. More interestingly, in the metallic phases of SrIrO{sub 3}, unusual non-Fermi liquid characteristics emerge in resistivity as Δρ ∝ T{sup ε} with ε evolving from 4/5 to 1 to 3/2 with increasing lattice strain. We discuss theoretical implications of these phenomena to shed light on the metal insulator transitions.« less

Investigation of Clostridium botulinum group III's mobilome content.

PubMed

Woudstra, Cédric; Le Maréchal, Caroline; Souillard, Rozenn; Anniballi, Fabrizio; Auricchio, Bruna; Bano, Luca; Bayon-Auboyer, Marie-Hélène; Koene, Miriam; Mermoud, Isabelle; Brito, Roseane B; Lobato, Francisco C F; Silva, Rodrigo O S; Dorner, Martin B; Fach, Patrick

2018-02-01

Clostridium botulinum group III is mainly responsible for botulism in animals. It could lead to high animal mortality rates and, therefore, represents a major environmental and economic concern. Strains of this group harbor the botulinum toxin locus on an unstable bacteriophage. Since the release of the first complete C. botulinum group III genome sequence (strain BKT015925), strains have been found to contain others mobile elements encoding for toxin components. In this study, seven assays targeting toxin genes present on the genetic mobile elements of C. botulinum group III were developed with the objective to better characterize C. botulinum group III strains. The investigation of 110 C. botulinum group III strains and 519 naturally contaminated samples collected during botulism outbreaks in Europe showed alpha-toxin and C2-I/C2-II markers to be systematically associated with type C/D bont-positive samples, which may indicate an important role of these elements in the pathogenicity mechanisms. On the contrary, bont type D/C strains and the related positive samples appeared to contain almost none of the markers tested. Interestingly, 31 bont-negative samples collected on farms after a botulism outbreak revealed to be positive for some of the genetic mobile elements tested. This suggests loss of the bont phage, either in farm environment after the outbreak or during laboratory handling. Copyright © 2017 Elsevier Ltd. All rights reserved.

Hydrology of the solid waste burial ground as related to potential migration of radionuclides, Idaho National Engineering Laboratory

USGS Publications Warehouse

Barraclough, Jack T.; Robertson, J.B.; Janzer, V.J.; Saindon, L.G.

1976-01-01

A study was made (1970-1974) to evaluate the geohydrologic and geochemical controls on subsurface migration of radionuclides from pits and trenches in the Idaho National Engineering Laboratory (INEL) solid waste burial ground and to determine the existence and extent of radionuclide migration from the burial ground. A total of about 1,700 sediment, rock, and water samples were collected from 10 observation wells drilled in and near the burial ground of Idaho National Engineering Laboratory, formerly the National Reactor Testing Station (NRTS). Within the burial ground area, the subsurface rocks are composed principally of basalt. Wind- and water-deposited sediments occur at the surface and in beds between the thicker basalt zones. Two principal sediment beds occur at about 110 feet and 240 feet below the land surface. The average thickness of the surficial sedimentary layer is about 15 feet while that of the two principal subsurface layers is 13 and 14 feet, respectively. The water table in the aquifer beneath the burial ground is at a depth of about 580 feet. Fission, activation, and transuranic elements were detected in some of the samples from the 110- and 240-foot sedimentary layers. (Woodard-USGS)

Ab initio molecular dynamics simulations of low energy recoil events in MgO

DOE PAGES

Petersen, B. A.; Liu, B.; Weber, W. J.; ...

2017-01-11

In this paper, low-energy recoil events in MgO are studied using ab initio molecular dynamics simulations to reveal the dynamic displacement processes and final defect configurations. Threshold displacement energies, E d, are obtained for Mg and O along three low-index crystallographic directions, [100], [110], and [111]. The minimum values for E d are found along the [110] direction consisting of the same element, either Mg or O atoms. Minimum threshold values of 29.5 eV for Mg and 25.5 eV for O, respectively, are suggested from the calculations. For other directions, the threshold energies are considerably higher, 65.5 and 150.0 eVmore » for O along [111] and [100], and 122.5 eV for Mg along both [111] and [100] directions, respectively. These results show that the recoil events in MgO are partial-charge transfer assisted processes where the charge transfer plays an important role. Finally, there is a similar trend found in other oxide materials, where the threshold displacement energy correlates linearly with the peak partial-charge transfer, suggesting this behavior might be universal in ceramic oxides.« less

A phenomenological creep model for nickel-base single crystal superalloys at intermediate temperatures

NASA Astrophysics Data System (ADS)

Gao, Siwen; Wollgramm, Philip; Eggeler, Gunther; Ma, Anxin; Schreuer, Jürgen; Hartmaier, Alexander

2018-07-01

For the purpose of good reproduction and prediction of creep deformation of nickel-base single crystal superalloys at intermediate temperatures, a phenomenological creep model is developed, which accounts for the typical γ/γ‧ microstructure and the individual thermally activated elementary deformation processes in different phases. The internal stresses from γ/γ‧ lattice mismatch and deformation heterogeneity are introduced through an efficient method. The strain hardening, the Orowan stress, the softening effect due to dislocation climb along γ/γ‧ interfaces and the formation of < 112> dislocation ribbons, and the Kear–Wilsdorf-lock effect as key factors in the main flow rules are formulated properly. By taking the cube slip in < 110> \\{100\\} slip systems and < 112> \\{111\\} twinning mechanisms into account, the creep behavior for [110] and [111] loading directions are well captured. Without specific interaction and evolution of dislocations, the simulations of this model achieve a good agreement with experimental creep results and reproduce temperature, stress and crystallographic orientation dependences. It can also be used as the constitutive relation at material points in finite element calculations with complex boundary conditions in various components of superalloys to predict creep behavior and local stress distributions.

Synthesis, characterization, crystal structure, DNA/BSA binding ability and antibacterial activity of asymmetric europium complex based on 1,10- phenanthroline

NASA Astrophysics Data System (ADS)

Alfi, Nafiseh; Khorasani-Motlagh, Mozhgan; Rezvani, Ali Reza; Noroozifar, Meissam; Molčanov, Krešimir

2017-06-01

A heteroleptic europium coordination compound formulated as [Eu(phen)2(OH2)2(Cl)2](Cl)(H2O) (phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis, FT-IR spectroscopy, and single-crystal X-ray diffractometer. Crystal structure analysis reveals the complex is crystallized in orthorhombic system with Pca21 space group. Electronic absorption and various emission methods for investigation of the binding system of europium(III) complex to Fish Salmon deoxyribonucleic acid (FS-DNA) and Bovamin Serum Albumin (BSA) have been explored. Furthermore, the binding constants, binding sites and the corresponding thermodynamic parameters of the interaction system based on the van't Hoff equation for FS-DNA and BSA were calculated. The thermodynamic parameters reflect the exothermic nature of emission process (ΔH°<0 and ΔS°<0). The experimental results seem to indicate that the [Eu(phen)2(OH2)2(Cl)2](Cl)(H2O) bound to FS-DNA by non-intercalative mode which the groove binding is preferable mode. Also, the complex exhibits a brilliant antimicrobial activity in vitro against standard bacterial strains.

Liquid petroleum gas sensing application of ZnO/CdO:ZnO nanocomposites at low temperature

NASA Astrophysics Data System (ADS)

Rajput, Jeevitesh K.; Pathak, T. K.; Kumar, V.; Swart, H. C.; Purohit, L. P.

2018-04-01

ZnO and CdO:ZnO nanoparticles are synthesized by sol-gel precipitation method. The structural analysis shows composite structure for CdO:ZnO nanoparticles with (002) and (111) phase. The SEM images show wedge like morphology and 3-D hexagonal morphology with ˜110 nm in size. The uniform growth of CdO:ZnO nanoparticles were observed in EDS element mapping image. LPG sensing was observed for CdO:ZnO nanoparticle with rapid sensing response 8.69% at operating temperature 50°C. This sensing response can be accounted due by absorption ions reactions at low operating temperature.

Shaping Ge islands on Si(001) surfaces with misorientation angle.

PubMed

Persichetti, L; Sgarlata, A; Fanfoni, M; Balzarotti, A

2010-01-22

A complete description of Ge growth on vicinal Si(001) surfaces in the angular miscut range 0 degrees -8 degrees is presented. The key role of substrate vicinality is clarified from the very early stages of Ge deposition up to the nucleation of 3D islands. By a systematic scanning tunneling microscopy investigation we are able to explain the competition between step-flow growth and 2D nucleation and the progressive elongation of the 3D islands along the miscut direction [110]. Using finite element calculations, we find a strict correlation between the morphological evolution and the energetic factors which govern the {105} faceting at atomic scale.

Surface-structural Control on Minor Element Zoning and Growth Mechanism in Synthetic Magmatic Clinopyroxene

NASA Astrophysics Data System (ADS)

Paquette, J.; Deakin, M.; Baker, D. R.

2006-12-01

Because in situ observations of actively growing surfaces are technically impractical, our understanding of crystal growth mechanisms at hydrothermal and magmatic conditions lags behind that of minerals that can be grown from aqueous solutions at or near room temperature. Growing silicate minerals from hydrous synthetic carbonate melts offers the opportunity to relate directly minor element incorporation to their surface microtopography. Natural hydrothermal diopside was used to seed experiments in which synthetic clinopyroxene crystals were grown at 800 degrees C and 10 kbars for 24 hours, from alkaline melts modelled after the lavas of the Tanzanian volcano Oldoinyo Lengai. The melts were prepared from Na2CO3, K2CO3, CaCO3, MgCO3 and Fe3O4 reagents. One run was anhydrous and the others contained either 2.5 or 5 wt. % H2O. Euhedral tabular crystals ranging in size from 100 to 300 ìm across were found in all three runs, hand-picked and freed from their carbonate matrix by overnight immersion in dilute acetic acid. The crystals consist of \\{110\\} prism, \\{100\\} and \\{001\\} pinacoids and a \\{111\\} dipyramid. AFM images resolved a distinct surface microtopography on each form: arrays of broad macrosteps on \\{100\\}, lens- shaped islands on \\{001\\} facets and striated fiber-like crystallites on \\{110\\}. EMP analyses of polished grain mounts show that compositional zoning of Na and Fe occurs not only among non-equivalent growth sectors but also within single \\{100\\} sectors. Electron microprobe maps of sequentially polished sections indicate that zoning within \\{100\\} sectors reflects differential uptake of Na and Fe on symmetrically non-equivalent steps. Near the crystal surface, the non- equivalent coeval vicinal faces of growth hillocks on \\{100\\} are either diopside-like, Na.007Ca1.00(Mg0.754Fe2+0.22Mn2+0.013Al_{0.003)Si2.00O6 , or acmitic, Ca0.63Na0.35(Mg0.64Fe3+ 0.36)Al0.01Si1.99O6 in composition. Step-specific incorporation of minor elements in a clinopyroxene face has only been documented once, in a hydrothermal diopside from Orford (Quebec), where Fe(II) and Mn(II) were differentially incorporated on steps oriented parallel to [010] on \\{100\\} faces. This natural example and our synthetic crystals reflect growth regimes where minor element incorporation was limited by surface-structural kinetics rather than diffusion- controlled kinetics. Such step-specific surface-structural control has never been reported in clinopyroxenes grown from silicate melts. Is it present, but more subtle, or do silicate melts promote a significantly different growth regime? Comparing zoning patterns in synthetic silicates grown from carbonate versus silicate melts could put new constraints on current models of element partitioning.

Trace elements in atmospheric particulate matter over a coal burning power production area of western Macedonia, Greece.

PubMed

Petaloti, Christina; Triantafyllou, Athanasios; Kouimtzis, Themistoklis; Samara, Constantini

2006-12-01

Total suspended particle (TSP) concentrations were determined in the Eordea basin (western Macedonia, Greece), an area with intensive lignite burning for power generation. The study was conducted over a one-year period (November 2000-November 2001) at 10 sites located at variable distances from the power plants. Ambient TSP samples were analyzed for 27 major, minor and trace elements. Annual means of TSP concentrations ranged between 47+/-33 microg m(-3) and 110+/-50 microg m(-3) at 9 out of the 10 sites. Only the site closest to the power stations and the lignite conveyor belts exhibited annual TSP levels (210+/-97 microg m(-3)) exceeding the European standard (150 microg m(-3), 80/779/EEC). Concentrations of TSP and almost all elemental components exhibited significant spatial variations; however, the elemental profiles of TSP were quite similar among all sites suggesting that they are affected by similar source types. At all sites, statistical analysis indicated insignificant (P<0.05) seasonal variation for TSP concentrations. Some elements (Cl, As, Pb, Br, Se, S, Cd) exhibited significantly higher concentrations at certain sites during the cold period suggesting more intense emissions from traffic, domestic heating and other combustion sources. On the contrary, concentrations significantly higher in the warm period were found at other sites mainly for crustal elements (Ti, Mn, K, P, Cr, etc.) suggesting stronger influence from soil resuspension and/or fly ash in the warm months. The most enriched elements against local soil or road dust were S, Cl, Cu, As, Se, Br, Cd and Pb, whereas negligible enrichment was found for Ti, Mn, Mg, Al, Si, P, Cr. At most sites, highest concentrations of TSP and elemental components were associated with low- to moderate-speed winds favoring accumulation of emissions from local sources. Influences from the power generation were likely at those sites located closest to the power plants and mining activities.

Structural and Thermodynamic Factors of Suppressed Interdiffusion Kinetics in Multi-component High-entropy Materials

PubMed Central

Chang, Shou-Yi; Li, Chen-En; Huang, Yi-Chung; Hsu, Hsun-Feng; Yeh, Jien-Wei; Lin, Su-Jien

2014-01-01

We report multi-component high-entropy materials as extraordinarily robust diffusion barriers and clarify the highly suppressed interdiffusion kinetics in the multi-component materials from structural and thermodynamic perspectives. The failures of six alloy barriers with different numbers of elements, from unitary Ti to senary TiTaCrZrAlRu, against the interdiffusion of Cu and Si were characterized, and experimental results indicated that, with more elements incorporated, the failure temperature of the barriers increased from 550 to 900°C. The activation energy of Cu diffusion through the alloy barriers was determined to increase from 110 to 163 kJ/mole. Mechanistic analyses suggest that, structurally, severe lattice distortion strains and a high packing density caused by different atom sizes, and, thermodynamically, a strengthened cohesion provide a total increase of 55 kJ/mole in the activation energy of substitutional Cu diffusion, and are believed to be the dominant factors of suppressed interdiffusion kinetics through the multi-component barrier materials. PMID:24561911

Effects of Transition Metals on the Grain Boundary Cohesion in Tungsten

DOE Office of Scientific and Technical Information (OSTI.GOV)

Setyawan, Wahyu; Kurtz, Richard J.

2012-04-01

We report on the effects of alloying transition metals on the interfacial cohesion of W {Sigma}27<110>{l_brace}525{r_brace} symmetrical tilt grain boundary (GB). Density-functional-theory calculations show that the effects are related to the sensitivity of the d-orbital's occupation with respect to the atomic environments at the GB. Systematic trends of cleavage energy as a function of the electronic valence of the impurities were observed across different interfacial positions. Segregation formation energies were calculated to study the stability of the substitutional sites. All of the energetically preferred sites also correspond to the positions at which the alloying elements increase the GB cleavage energy.more » For each element, the more stable the configuration, the higher the cleavage energy. This finding is crucial in designing polycrystalline W-alloys with improved fracture toughness. Considering the solubility limit, the results suggest that Ta, Nb, Re, Ru, and Os are potential additives against intergranular fracture.« less

Equation of State of Fe3C and Implications for the Carbon Content of Earth's Core

NASA Astrophysics Data System (ADS)

Davis, A.; Brauser, N.; Thompson, E. C.; Chidester, B.; Greenberg, E.; Prakapenka, V. B.; Campbell, A.

2017-12-01

Carbon is a common component in protoplanetary cores, as represented by iron meteorites. Therefore, along with silicon, oxygen, and other light elements, it is likely to be an alloying component with iron in Earth's core. Previous studies of the densities of iron carbides have not reached the combined pressure and temperature conditions relevant to Earth's core. To better understand the geophysical implications of carbon addition to Earth's core, we report P-V-T measurements of Fe3C to pressures and temperatures exceeding 110 GPa and 2500 K, using synchrotron X-ray diffraction in a laser heated diamond anvil cell. Fitting these measurements to an equation of state and assuming 1.5% density change upon melting and a 4000 K core-mantle boundary temperature, we report a value of 6 wt% carbon necessary to match the PREM density in the outer core. This value should be considered an upper bound due to the likely presence of other light elements.

Lunar highland rocks - Element partitioning among minerals. II - Electron microprobe analyses of Al, P, Ca, Ti, Cr, Mn and Fe in olivine

NASA Technical Reports Server (NTRS)

Smith, J. V.; Hansen, E. C.; Steele, I. M.

1980-01-01

Lunar olivines from anorthosites, granulitic impactites, and rocks in the Mg-rich plutonic trend were subjected to electron probe measurements for Al, P, Ca, Ti, Cr and Mn, which show that the FeO/MnO ratio for lunar olivines lies between 80 and 110 with little difference among the rock types. The low values of Ca in lunar olivines indicate slow cooling to subsolidus temperatures, with blocking temperatures of about 750 C for 67667 and 1000 C for 60255,73-alpha determined by the Finnerty and Boyd (1978) experiments. An important paradox is noted in the low Ti content of Fe-rich olivines from anorthosites, although both Ti and Fe tend to become enriched in liquid during fractional distillation. Except for Ca and Mn, olivine from anorthosites has lower minor element values than other rock types. Formation from a chemically distinct system is therefore implied.

New insights on Ba overabundance in open clusters. Evidence for the intermediate neutron-capture process at play?

NASA Astrophysics Data System (ADS)

Mishenina, T.; Pignatari, M.; Carraro, G.; Kovtyukh, V.; Monaco, L.; Korotin, S.; Shereta, E.; Yegorova, I.; Herwig, F.

2015-02-01

Recently, an increasing number of studies were devoted to measure the abundances of neutron-capture elements heavier than iron in stars belonging to Galactic Open Clusters (OCs). OCs span a sizeable range in metallicity (-0.6 ≤ [Fe/H] ≤ +0.4), and they show abundances of light elements similar to disc stars of the same age. A different pattern is observed for heavy elements. A large scatter is observed for Ba, with most OCs showing [Ba/Fe] and [Ba/La] overabundant with respect to the Sun. The origin of this overabundance is not clearly understood. With the goal of providing new observational insights, we determined radial velocities, atmospheric parameters and chemical composition of 27 giant stars members of five OCs: Cr 110, Cr 261, NGC 2477, NGC 2506 and NGC 5822. We used high-resolution spectra obtained with the UVES spectrograph at European Southern Observatory Paranal. We perform a detailed spectroscopic analysis of these stars to measure the abundance of up to 22 elements per star. We study the dependence of element abundance on metallicity and age with unprecedented detail, complementing our analysis with data culled from the literature. We confirm the trend of Ba overabundance in OCs, and show its large dispersion for clusters younger than ˜4 Gyr. Finally, the implications of our results for stellar nucleosynthesis are discussed. We show in this work that the Ba enrichment compared to other neutron-capture elements in OCs cannot be explained by the contributions from the slow neutron-capture process and the rapid neutron-capture process. Instead, we argue that this anomalous signature can be explained by assuming an additional contribution by the intermediate neutron-capture process.

An open source software tool to assign the material properties of bone for ABAQUS finite element simulations.

PubMed

Pegg, Elise C; Gill, Harinderjit S

2016-09-06

A new software tool to assign the material properties of bone to an ABAQUS finite element mesh was created and compared with Bonemat, a similar tool originally designed to work with Ansys finite element models. Our software tool (py_bonemat_abaqus) was written in Python, which is the chosen scripting language for ABAQUS. The purpose of this study was to compare the software packages in terms of the material assignment calculation and processing speed. Three element types were compared (linear hexahedral (C3D8), linear tetrahedral (C3D4) and quadratic tetrahedral elements (C3D10)), both individually and as part of a mesh. Comparisons were made using a CT scan of a hemi-pelvis as a test case. A small difference, of -0.05kPa on average, was found between Bonemat version 3.1 (the current version) and our Python package. Errors were found in the previous release of Bonemat (version 3.0 downloaded from www.biomedtown.org) during calculation of the quadratic tetrahedron Jacobian, and conversion of the apparent density to modulus when integrating over the Young׳s modulus field. These issues caused up to 2GPa error in the modulus assignment. For these reasons, we recommend users upgrade to the most recent release of Bonemat. Processing speeds were assessed for the three different element types. Our Python package took significantly longer (110s on average) to perform the calculations compared with the Bonemat software (10s). Nevertheless, the workflow advantages of the package and added functionality makes 'py_bonemat_abaqus' a useful tool for ABAQUS users. Copyright © 2016 Elsevier Ltd. All rights reserved.

Estimation of the Young's modulus of the human pars tensa using in-situ pressurization and inverse finite-element analysis.

PubMed

Rohani, S Alireza; Ghomashchi, Soroush; Agrawal, Sumit K; Ladak, Hanif M

2017-03-01

Finite-element models of the tympanic membrane are sensitive to the Young's modulus of the pars tensa. The aim of this work is to estimate the Young's modulus under a different experimental paradigm than currently used on the human tympanic membrane. These additional values could potentially be used by the auditory biomechanics community for building consensus. The Young's modulus of the human pars tensa was estimated through inverse finite-element modelling of an in-situ pressurization experiment. The experiments were performed on three specimens with a custom-built pressurization unit at a quasi-static pressure of 500 Pa. The shape of each tympanic membrane before and after pressurization was recorded using a Fourier transform profilometer. The samples were also imaged using micro-computed tomography to create sample-specific finite-element models. For each sample, the Young's modulus was then estimated by numerically optimizing its value in the finite-element model so simulated pressurized shapes matched experimental data. The estimated Young's modulus values were 2.2 MPa, 2.4 MPa and 2.0 MPa, and are similar to estimates obtained using in-situ single-point indentation testing. The estimates were obtained under the assumptions that the pars tensa is linearly elastic, uniform, isotropic with a thickness of 110 μm, and the estimates are limited to quasi-static loading. Estimates of pars tensa Young's modulus are sensitive to its thickness and inclusion of the manubrial fold. However, they do not appear to be sensitive to optimization initialization, height measurement error, pars flaccida Young's modulus, and tympanic membrane element type (shell versus solid). Copyright © 2017 Elsevier B.V. All rights reserved.

Fabrication of a two-dimensional piezoelectric micromachined ultrasonic transducer array using a top-crossover-to-bottom structure and metal bridge connections

NASA Astrophysics Data System (ADS)

Jung, Joontaek; Kim, Sangwon; Lee, Wonjun; Choi, Hongsoo

2013-12-01

A new design methodology and fabrication process for two-dimensional (2D) piezoelectric micromachined ultrasonic transducer (pMUT) arrays using a top-crossover-to-bottom (TCTB) structure was developed. Individual sensing and actuation of pMUT elements from a small number of connection lines was enabled by the TCTB structure, and the parasitic coupling capacitance of the array was significantly reduced as a result. A 32 × 32 pMUT array with a TCTB structure was fabricated, resulting in 64 connection lines over an area of 4.8 × 4.8 mm2. The top electrodes for each pMUT element were re-connected by metal bridging after bottom-electrode etching caused them to become disconnected. A deep reactive ion etching process was used to compactify the array. Each pMUT element was a circular-shaped K31-type ultrasonic transducer using a 1 µm thick sol-gel lead zirconate titanate (PZT: Pb1.10 Zr0.52 Ti0.48) thin film. To characterize a single element in the 2D pMUT array, the resonant frequency and coupling coefficient of 20 pMUT elements were averaged to 3.85 MHz and 0.0112, respectively. The maximum measured ultrasound intensity in water, measured at a distance of 4 mm, was 4.6 µW cm-2 from a single pMUT element driven by a 5 Vpp sine wave at 2.22 MHz. Potential applications for development of a TCTB-arranged 2D pMUT array include ultrasonic medical imaging, ultrasonic communication, ultrasonic range-finding and handwriting input systems.

A correlation between the heavy element content of transiting extrasolar planets and the metallicity of their parent stars

NASA Astrophysics Data System (ADS)

Guillot, T.; Santos, N. C.; Pont, F.; Iro, N.; Melo, C.; Ribas, I.

2006-07-01

Context.Nine extrasolar planets with masses between 110 and 430 M_⊕ are known to transit their star. The knowledge of their masses and radii allows an estimate of their composition, but uncertainties on equations of state, opacities and possible missing energy sources imply that only inaccurate constraints can be derived when considering each planet separately.Aims.We seek to better understand the composition of transiting extrasolar planets by considering them as an ensemble, and by comparing the obtained planetary properties to that of the parent stars.Methods.We use evolution models and constraints on the stellar ages to derive the mass of heavy elements present in the planets. Possible additional energy sources like tidal dissipation due to an inclined orbit or to downward kinetic energy transport are considered.Results.We show that the nine transiting planets discovered so far belong to a quite homogeneous ensemble that is characterized by a mass of heavy elements that is a relatively steep function of the stellar metallicity, from less than 20 earth masses of heavy elements around solar composition stars, to up to ~100 M_⊕ for three times the solar metallicity (the precise values being model-dependant). The correlation is still to be ascertained however. Statistical tests imply a worst-case 1/3 probability of a false positive.Conclusions.Together with the observed lack of giant planets in close orbits around metal-poor stars, these results appear to imply that heavy elements play a key role in the formation of close-in giant planets. The large masses of heavy elements inferred for planets orbiting metal rich stars was not anticipated by planet formation models and shows the need for alternative theories including migration and subsequent collection of planetesimals.

Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis.

PubMed

Matheny, Ronald W; Riddle-Kottke, Melissa A; Leandry, Luis A; Lynch, Christine M; Abdalla, Mary N; Geddis, Alyssa V; Piper, David R; Zhao, Jean J

2015-04-01

Phosphoinositide 3-OH kinase (PI3K) regulates a number of developmental and physiologic processes in skeletal muscle; however, the contributions of individual PI3K p110 catalytic subunits to these processes are not well-defined. To address this question, we investigated the role of the 110-kDa PI3K catalytic subunit β (p110β) in myogenesis and metabolism. In C2C12 cells, pharmacological inhibition of p110β delayed differentiation. We next generated mice with conditional deletion of p110β in skeletal muscle (p110β muscle knockout [p110β-mKO] mice). While young p110β-mKO mice possessed a lower quadriceps mass and exhibited less strength than control littermates, no differences in muscle mass or strength were observed between genotypes in old mice. However, old p110β-mKO mice were less glucose tolerant than old control mice. Overexpression of p110β accelerated differentiation in C2C12 cells and primary human myoblasts through an Akt-dependent mechanism, while expression of kinase-inactive p110β had the opposite effect. p110β overexpression was unable to promote myoblast differentiation under conditions of p110α inhibition, but expression of p110α was able to promote differentiation under conditions of p110β inhibition. These findings reveal a role for p110β during myogenesis and demonstrate that long-term reduction of skeletal muscle p110β impairs whole-body glucose tolerance without affecting skeletal muscle size or strength in old mice. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

A mass-balance model to separate and quantify colloidal and solute redistributions in soil

USGS Publications Warehouse

Bern, C.R.; Chadwick, O.A.; Hartshorn, A.S.; Khomo, L.M.; Chorover, J.

2011-01-01

Studies of weathering and pedogenesis have long used calculations based upon low solubility index elements to determine mass gains and losses in open systems. One of the questions currently unanswered in these settings is the degree to which mass is transferred in solution (solutes) versus suspension (colloids). Here we show that differential mobility of the low solubility, high field strength (HFS) elements Ti and Zr can trace colloidal redistribution, and we present a model for distinguishing between mass transfer in suspension and solution. The model is tested on a well-differentiated granitic catena located in Kruger National Park, South Africa. Ti and Zr ratios from parent material, soil and colloidal material are substituted into a mixing equation to quantify colloidal movement. The results show zones of both colloid removal and augmentation along the catena. Colloidal losses of 110kgm-2 (-5% relative to parent material) are calculated for one eluviated soil profile. A downslope illuviated profile has gained 169kgm-2 (10%) colloidal material. Elemental losses by mobilization in true solution are ubiquitous across the catena, even in zones of colloidal accumulation, and range from 1418kgm-2 (-46%) for an eluviated profile to 195kgm-2 (-23%) at the bottom of the catena. Quantification of simultaneous mass transfers in solution and suspension provide greater specificity on processes within soils and across hillslopes. Additionally, because colloids include both HFS and other elements, the ability to quantify their redistribution has implications for standard calculations of soil mass balances using such index elements. ?? 2011.

Influence of chemical composition of zirconium alloy E110 on embrittlement under LOCA conditions - Part 1: Oxidation kinetics and macrocharacteristics of structure and fracture

NASA Astrophysics Data System (ADS)

Nikulin, S. A.; Rozhnov, A. B.; Belov, V. A.; Li, E. V.; Glazkina, V. S.

2011-11-01

Exploratory investigations of the influence of alloying and impurity content in the E110 alloy cladding tubes on the behavior under conditions of Loss of Coolant Accidents (LOCA) has been performed. Three alloys of E110 type have been tested: E110 alloy of nominal composition Zr-1%Nb (E110), E110 alloy of modified composition Zr-1%Nb-0.12%Fe-0.13%O (E110M), E110 alloy of nominal composition Zr-1%Nb with reduced impurity content (E110G). Alloys E110 and E110M were manufactured on the electrolytic basis and alloy E110G was manufactured on the basis of zirconium sponge. The high temperature oxidation tests in steam ( T = 1100 °C, 18% of equivalent cladding reacted (ECR)) have been conducted, kinetics of oxidation was investigated. Quantitative research of structure and fracture macrocharacteristics was performed by means of optical and electron microscopy. The results received were compared with the residual ductility of specimens. The results of the investigation showed the existence of "breakaway oxidation" kinetics and white spalling oxide in E110 and E110M alloys while the specimen oxidation kinetics in E110G alloy was characterized by a parabolic law and specimens had a dense black oxide. Oxygen and iron alloying in the E110 alloy positively changed the macrocharacteristics of structure and fracture. However, in general, it did not improve the resistance to embrittlement in LOCA conditions apparently because of a strong impurity influence caused by electrolytic process of zirconium production.

Cationic metal complex, carbonatobis(1,10-phenanthroline)cobalt(III) as anion receptor: Synthesis, characterization, single crystal X-ray structure and packing analysis of [Co(phen) 2CO 3](3,5-dinitrobenzoate)·5H 2O

NASA Astrophysics Data System (ADS)

Sharma, Raj Pal; Singh, Ajnesh; Brandão, Paula; Felix, Vitor; Venugopalan, Paloth

2009-03-01

To explore the potential of [Co(phen) 2CO 3] + as anion receptor, red coloured single crystals of [Co(phen) 2CO 3](dnb)·5H 2O (dnb = 3,5-dinitrobenzoate) were obtained by recrystallizing the red microcrystalline product synthesised by the reaction of carbonatobis (1,10-phenanthroline)cobalt(III)chloride with sodium salt of 3,5-dinitrobenzoic acid in aqueous medium (1:1 molar ratio). The newly synthesized complex salt has been characterized by elemental analysis, spectroscopic studies (IR, UV/visible, 1H and 13C NMR), solubility and conductance measurements. The complex salt crystallizes in the triclinic crystal system with space group P1¯, having the cell dimensions a = 10.3140(8), b = 12.2885(11), c = 12.8747(13), α = 82.095(4), β = 85.617(4), γ = 79.221(4)°, V = 1585.6(2) Å 3, Z = 2. Single crystal X-ray structure determination revealed ionic structure consisting of cationic carbonatobis(1,10-phenanthroline)cobalt(III), dnb anion and five lattice water molecule. In the complex cation [Co(phen) 2CO 3] +, the cobalt(III) is bonded to four nitrogen atoms, originating from two phenanthroline ligands and two oxygen atoms from the bidentate carbonato group showing an octahedral geometry around cobalt(III) center. Supramolecular networks between ionic groups [ CHphen+⋯Xanion-] by second sphere coordination i.e. C sbnd H⋯O (benzoate), C sbnd H⋯O (nitro), C sbnd H⋯O (water) besides electrostatic forces of attraction alongwith π-π interactions stabilize the crystal lattice.

Progress in Solving the Elusive Ag Transport Mechanism in TRISO Coated Particles: What is new?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isabella Van Rooyen

2014-10-01

The TRISO particle for HTRs has been developed to an advanced state where the coating withstands internal gas pressures and retains fission products during irradiation and under postulated accidents. However, one exception is Ag that has been found to be released from high quality TRISO coated particles when irradiated and can also during high temperature accident heating tests. Although out- of- pile laboratory tests have never hither to been able to demonstrate a diffusion process of Ag in SiC, effective diffusion coefficients have been derived to successfully reproduce measured Ag-110m releases from irradiated HTR fuel elements, compacts and TRISO particlesmore » It was found that silver transport through SiC does not proceed via bulk volume diffusion. Presently grain boundary diffusion that may be irradiation enhanced either by neutron bombardment or by the presence of fission products such as Pd, are being investigated. Recent studies of irradiated AGR-1 TRISO fuel using scanning transmission electron microscopy (STEM), transmission kukuchi diffraction (TKD) patterns and high resolution transmission electron microscopy (HRTEM) have been used to further the understanding of Ag transport through TRISO particles. No silver was observed in SiC grains, but Ag was identified at triple-points and grain boundaries of the SiC layer in the TRISO particle. Cadmium was also found in some of the very same triple junctions, but this could be related to silver behavior as Ag-110m decays to Cd-110. Palladium was identified as the main constituent of micron-sized precipitates present at the SiC grain boundaries and in most SiC grain boundaries and the potential role of Pd in the transport of Ag will be discussed.« less

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

PubMed

Hale, Benjamin G; Batty, Ian H; Downes, C Peter; Randall, Richard E

2008-01-18

Influenza A virus NS1 protein stimulates host-cell phosphoinositide 3-kinase (PI3K) signaling by binding to the p85beta regulatory subunit of PI3K. Here, in an attempt to establish a mechanism for this activation, we report further on the functional interaction between NS1 and p85beta. Complex formation was found to be independent of NS1 RNA binding activity and is mediated by the C-terminal effector domain of NS1. Intriguingly, the primary direct binding site for NS1 on p85beta is the inter-SH2 domain, a coiled-coil structure that acts as a scaffold for the p110 catalytic subunit of PI3K. In vitro kinase activity assays, together with protein binding competition studies, reveal that NS1 does not displace p110 from the inter-SH2 domain, and indicate that NS1 can form an active heterotrimeric complex with PI3K. In addition, it was established that residues at the C terminus of the inter-SH2 domain are essential for mediating the interaction between p85beta and NS1. Equivalent residues in p85alpha have previously been implicated in the basal inhibition of p110. However, such p85alpha residues were unable to substitute for those in p85beta with regards NS1 binding. Overall, these data suggest a model by which NS1 activates PI3K catalytic activity by masking a normal regulatory element specific to the p85beta inter-SH2 domain.

Analysis of the Symbiotic Performance of Bradyrhizobium japonicum USDA 110 and Its Derivative I-110 and Discovery of a New Mannitol-Utilizing, Nitrogen-Fixing USDA 110 Derivative.

PubMed

Mathis, J N; Israel, D W; Barbour, W M; Jarvis, B D; Elkan, G H

1986-07-01

Previously, Bradyrhizobium japonicum USDA 110 was shown to contain colony morphology variants which differed in nitrogen-fixing ability. Mannitol-utilizing derivatives L1-110 and L2-110 have been shown to be devoid of symbiotic nitrogen fixation ability, and non-mannitol-utilizing derivatives I-110 and S-110 have been shown to be efficient at nitrogen fixation. The objectives of this study were to determine the effect of media carbon sources on the symbiotic N(2)-fixing ability of strain USDA 110 and to compare the effectiveness of strain USDA 110 and derivative I-110. Based on acetylene reduction activity and the nitrogen content of 41-day-old soybean plants, neither derivative I-110 nor cultures of USDA 110 grown in media favoring non-mannitol-using derivatives had symbiotic nitrogen fixation that was statistically superior to that of cultures of USDA 110 grown in media favoring mannitol-using derivatives. In another experiment 200 individual nodules formed by strain USDA 110 grown in yeast extract gluconate were screened for colony morphology of occupying variant(s) and acetylene reduction activity. Nodules occupied by mannitol-using derivatives (large colony type on 0.1% yeast extract-0.05% K(2)HPO(4)-0.08% MgSO(4) . 7H(2)O-0.02% NaCl-0.001% FeCl(3) . 6H(2)O [pH 6.7] with 1% mannitol [YEM] plates) had a mean acetylene reduction activity equal to that of nodules occupied by non-mannitol-using derivatives (small colony type on YEM plates). A total of 20 large colonial derivatives and 10 small colonial derivatives (I-110-like) were isolated and purified by repeated culture in YEM and YEG (same as YEM except 1% gluconate instead of 1% mannitol) media, respectively, followed by dilution in solutions containing 0.05% Tween 40. After 25 days of growth, soybean plants inoculated with the large colony isolates had mean whole-plant acetylene reduction activity, whole-plant dry weight, and whole-plant nitrogen contents equal to or better than those of plants inoculated with either the small colony isolates (I-110-like) or the I-110 (non-mannitol-using) derivative. Hence, the existence of a mannitol-utilizing derivative that fixes nitrogen in a culture of strain USDA 110 obtained from the U.S. Department of Agriculture, Beltsville, Md., was established. This new USDA 110 derivative was designated as MN-110 because it was a mannitol-utilizing nitrogen-fixing USDA 110 derivative. This derivative was morphologically indistinguishable from the non-nitrogen-fixing derivative L2-110 found in cultures obtained earlier from the U.S. Department of Agriculture, Beltsville. DNA-DNA homology and restriction enzyme analyses indicated that MN-110 is genetically related to other USDA 110 derivatives that have been characterized previously.

Trace elements in primitive meteorites—VII Antarctic unequilibrated ordinary chondrites

NASA Astrophysics Data System (ADS)

Wang, Ming-Sheng; Lipschutz, Michael E.

2007-02-01

We report RNAA results for Co, Au, Sb, Ga, Rb, Cs, Se, Ag, Te, Zn, In, Bi, Tl and Cd (in increasing order of metamorphic mobility) in 22 Antarctic unequilibrated ordinary chondrites (UOC). This brings to 38 the number of UOC for which data for highly volatile elements are known. For elements of lesser mobility (Co to Se, omitting Cs) overall variability in UOC are low, relative standard deviations (one sigma) being no more than a factor of two. For Ag, Te and Zn, relative standard deviations are 2-4×, while for Cs and the four most volatile elements, the variabilities are 8-110×. Elemental abundances do not vary with chemical type (H, L and LL) nor with UOC subtype (3.0-3.9). Contents of all elements reach levels up to, even exceeding, cosmic and all but Cd and the two alkalis, seem unaffected by post-accretionary processes. Contents of highly volatile elements are consistent with the idea that source regions producing contemporary falls and older Antarctic UOC differed in thermal histories. The presence or absence of carbide magnetite assemblages (CMA) generally accords with high or low Cd contents, respectively. This relationship accords with the prior suggestion that CMA formed by alteration of Fe-Ni metal by C-O-H-containing fluids at temperatures <700 K, generated by thermal metamorphism in parent body interiors. The absence of CMA in most UOC (and OC), may indicate that they were subsequently destroyed as metamorphic intensity increased. The high, often supercosmic, Rb and Cs levels in UOC may result from their high solubility in liquid water signalling their redistribution by C-O-H-containing fluid while in the liquid water field. Because of its uniquely high mobility, Cd could have been enriched by the C-O-H fluids and should have been lost from parent regions during later, higher temperature anhydrous metamorphism at temperatures in the 500-600 °C range.

Composites reinforced via mechanical interlocking of surface-roughened microplatelets within ductile and brittle matrices.

PubMed

Libanori, R; Carnelli, D; Rothfuchs, N; Binelli, M R; Zanini, M; Nicoleau, L; Feichtenschlager, B; Albrecht, G; Studart, A R

2016-04-12

Load-bearing reinforcing elements in a continuous matrix allow for improved mechanical properties and can reduce the weight of structural composites. As the mechanical performance of composite systems are heavily affected by the interfacial properties, tailoring the interactions between matrices and reinforcing elements is a crucial problem. Recently, several studies using bio-inspired model systems suggested that interfacial mechanical interlocking is an efficient mechanism for energy dissipation in platelet-reinforced composites. While cheap and effective solutions are available at the macroscale, the modification of surface topography in micron-sized reinforcing elements still represents a challenging task. Here, we report a simple method to create nanoasperities with tailored sizes and densities on the surface of alumina platelets and investigate their micromechanical effect on the energy dissipation mechanisms of nacre-like materials. Composites reinforced with roughened platelets exhibit improved mechanical properties for both organic ductile epoxy and inorganic brittle cement matrices. Mechanical interlocking increases the modulus of toughness (area under the stress-strain curve) by 110% and 56% in epoxy and cement matrices, respectively, as compared to those reinforced with flat platelets. This interlocking mechanism can potentially lead to a significant reduction in the weight of mechanical components while retaining the structural performance required in the application field.

[Analysis of cis-regulatory element distribution in gene promoters of Gossypium raimondii and Arabidopsis thaliana].

PubMed

Sun, Gao-Fei; He, Shou-Pu; Du, Xiong-Ming

2013-10-01

Cotton genomic studies have boomed since the release of Gossypium raimondii draft genome. In this study, cis-regulatory element (CRE) in 1 kb length sequence upstream 5' UTR of annotated genes were selected and scanned in the Arabidopsis thaliana (At) and Gossypium raimondii (Gr) genomes, based on the database of PLACE (Plant cis-acting Regulatory DNA Elements). According to the definition of this study, 44 (12.3%) and 57 (15.5%) CREs presented "peak-like" distribution in the 1 kb selected sequences of both genomes, respectively. Thirty-four of them were peak-like distributed in both genomes, which could be further categorized into 4 types based on their core sequences. The coincidence of TATABOX peak position and their actual position ((-) -30 bp) indicated that the position of a common CRE was conservative in different genes, which suggested that the peak position of these CREs was their possible actual position of transcription factors. The position of a common CRE was also different between the two genomes due to stronger length variation of 5' UTR in Gr than At. Furthermore, most of the peak-like CREs were located in the region of -110 bp-0 bp, which suggested that concentrated distribution might be conductive to the interaction of transcription factors, and then regulate the gene expression in downstream.

New bioinformatic tool for quick identification of functionally relevant endogenous retroviral inserts in human genome.

PubMed

Garazha, Andrew; Ivanova, Alena; Suntsova, Maria; Malakhova, Galina; Roumiantsev, Sergey; Zhavoronkov, Alex; Buzdin, Anton

2015-01-01

Endogenous retroviruses (ERVs) and LTR retrotransposons (LRs) occupy ∼8% of human genome. Deep sequencing technologies provide clues to understanding of functional relevance of individual ERVs/LRs by enabling direct identification of transcription factor binding sites (TFBS) and other landmarks of functional genomic elements. Here, we performed the genome-wide identification of human ERVs/LRs containing TFBS according to the ENCODE project. We created the first interactive ERV/LRs database that groups the individual inserts according to their familial nomenclature, number of mapped TFBS and divergence from their consensus sequence. Information on any particular element can be easily extracted by the user. We also created a genome browser tool, which enables quick mapping of any ERV/LR insert according to genomic coordinates, known human genes and TFBS. These tools can be used to easily explore functionally relevant individual ERV/LRs, and for studying their impact on the regulation of human genes. Overall, we identified ∼110,000 ERV/LR genomic elements having TFBS. We propose a hypothesis of "domestication" of ERV/LR TFBS by the genome milieu including subsequent stages of initial epigenetic repression, partial functional release, and further mutation-driven reshaping of TFBS in tight coevolution with the enclosing genomic loci.

[The establishment and meaning of the three-dimensional finite element model of pelvic floor levator ani muscle in an old healthy woman].

PubMed

Chen, Wei; Wn, Lijun; Yan, Zhihan; Wang, Jusong; Fu, Yalan; Chen, Xiongfei; Liu, Kun; Wu, Zhipeng

2011-10-01

This paper is to establish a three-dimensional finite element model (3D-FEM) of pelvic floor levator ani muscles in an old healthy women. We acquired the image data of the pelvic bones and pelvic floor muscles from CT and MRI scanning in a non-pregnant old healthy female volunteers. The 3-D reconstruction and mesh optimization of the whole pelvic bones and muscles with application of image processing software Mimics12.0 and Geomagic9.0 were obtained. Then we built the 3D-FEM of the musculoskeletal system of the pelvic bones and levator ani muscles with Ansys11.0 software. We obtained an accurate 3D-FEM of pelvic bones and levator ani muscles in the older healthy woman. The results showed that it was reliable to build 3D-FEM with CT and MRI scanning data and this model could vividly reflect the huge space anatomy of the real pelvic floor levator ani muscles. It avoids the defects to gain the model from the body of anatomical specimens in the past. The image data of model are closer to vivisection, and the model is more conducive to the latter finite element analysis.

Evolution of magnetism in single-crystal C a 2 R u 1 - x I r x O 4 ( 0 ≤ x ≤ 0.65 )

DOE PAGES

Yuan, S. J.; Terzic, J.; Wang, J. C.; ...

2015-07-24

In this paper, we report structural, magnetic, transport, and thermal properties of single-crystal Ca 2Ru 1-xIr xO 4(0≤x≤0.65). Ca 2RuO 4 is a structurally driven Mott insulator with a metal-insulator transition at T MI=357K, which is well separated from antiferromagnetic order at T N=110K. Substitution of a 5d element, Ir, for Ru enhances spin-orbit coupling and locking between the structural distortions and magnetic moment canting. Ir doping intensifies the distortion or rotation of Ru/IrO 6 octahedra and induces weak ferromagnetic behavior along the c axis. In particular, Ir doping suppresses T N but concurrently causes an additional magnetic ordering Tmore » N2 at a higher temperature up to 210 K for x=0.65. The effect of Ir doping sharply contrasts with that of 3d-element doping such as Cr, Mn, and Fe, which suppresses T N and induces unusual negative volume thermal expansion. Finally, the stark difference between 3d- and 5d-element doping underlines a strong magnetoelastic coupling inherent in the Ir-rich oxides.« less

Partially etched Ti3AlC2 as a promising high capacity Lithium-ion battery anode.

PubMed

Chen, Xifan; Zhu, Yuanzhi; Zhu, Xiaoquan; Peng, Wenchao; Li, Yang; Zhang, Guoliang; Zhang, Fengbao; Fan, Xiaobin

2018-06-25

MXenes, a family of two-dimensional transition-metal carbide and nitride materials, are supposed to be the promising materials in energy storage because of the high electronic conductivity, hydrophilic surfaces and low diffusion barriers. MXenes are generally prepared by removing the "A" elements (A = Al, Si, Sn, etc.) from their corresponding MAX phases by using hydrofluoric acid (HF) and the other etching agents, despite the fact that these "A" elements usually have great volumetric and gravimetric capacities. Herein, we studied the etching progress of Ti3AlC2 and evaluated their anode performance in Lithium-ion batteries. We found that a partially etched sample (0.5h-peTi3C2Tx) showed much higher capacity (160 mA h g-1, 331.6 mA h cm-3 at 1C) when compared with the fully etched Ti3C2Tx (110 mA h g-1, 190.3 mA h cm-3 at 1C). Besides, a 99% capacity retention was observed even after 1000 cycles in the 0.5h-peTi3C2Tx anode. This interesting result can be explained, at least in part, by the alloying of the residue Al element during lithiation. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

21 CFR 110.110 - Natural or unavoidable defects in food for human use that present no health hazard.

Code of Federal Regulations, 2011 CFR

2011-04-01

... use that present no health hazard. 110.110 Section 110.110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING... unavoidable defects in food for human use that present no health hazard. (a) Some foods, even when produced...

Assimilation of trace elements ingested by the mussel Mytilus edulis: effects of algal food abundance

USGS Publications Warehouse

Wang, W.-X.; Fisher, N.S.; Luoma, S.N.

1995-01-01

Pulse-chase feeding and multi-labeled radiotracer techniques were employed to measure the assimilation of 6 trace elements (110mAg, 241Am, 109Cd, 57Co, 75Se and 65Zn) from ingested diatoms in the mussel Mytilus edulis feeding at different rates (0.1, 0.49 and 1.5 mg dry wt h-1). Uniformly radiolabeled diatoms Thalassiosira pseudonana were fed to mussels for 0.5 h, and the behavior of the radiotracers in individual mussels was followed for 96 h in a depuration seawater system. Assimilation efficiency (AE) of each element declined with increasing ingestion rate and increased with gut passage time. The importance of extracellular digestion relative to intracellular digestion increased with ingestion activity, which, when coupled with a decline in AE, suggested that extracellular digestion is less efficient in metal absorption. Zn assimilation was most affected by ingestion rate, suggesting that AE may play a role in the physiological regulation of this metal in M. edulis. In an experiment to simulate the effects of an acidic gut, lowered pH (5.5) enhanced the release of elements from intact diatom cells, especially at low particle concentration. These results indicate that both feeding components of the mussel (i.e. gut passage time, digestive partitioning) and metal chemistry (i.e. metal release at lowered pH within the bivalve gut) are responsible for the difference in the assimilation of trace metals at different food quantities observed in mussels.

A direct link between chorus emissions and pulsating aurora on timescales from milliseconds to minutes: A case study at subauroral latitudes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozaki, Mitsunori; Yagitani, Satoshi; Sawai, Kaoru

A correlation was observed between chorus emissions and pulsating aurora (PA) from observations at Athabasca (L ≈ 4.3) in Canada at 9:00–9:20 UT on 7 February 2013, using an electron multiplying charge-coupled device camera and a VLF loop antenna with sampling rates of 110 Hz and 100 kHz, respectively. Pulsating aurora having a quasiperiodic variation in luminosity and a few hertz modulation was observed together with chorus emissions consisting of a group of successive rising-tone elements. The repetition period and modulation frequency of the PA are in good agreement with those of the modulated chorus. After 9:11 UT, the temporalmore » features of the aurora became aperiodic PA of indistinct modulation. Simultaneously, the rising-tone chorus turned into chorus emissions consisting of numerous rising-tone elements. The equatorial geomagnetic field inhomogeneity calculated using the Tsyganenko 2002 model shows a decreasing trend during the period. This result is consistent with nonlinear wave growth theory having a small geomagnetic field inhomogeneity, which contributes to a decrease in the threshold amplitude to trigger discrete chorus elements. As a result, these observations show a close connection between chorus emissions and PA on timescales from milliseconds for generation of discrete chorus elements on the microphysics of wave-particle interaction to minutes for the variations of the geomagnetic field inhomogeneity related with the substorm activity.« less

Spectral and Wavefront Error Performance of WFIRST/AFTA Prototype Filters

NASA Technical Reports Server (NTRS)

Quijada, Manuel; Seide, Laurie; Marx, Cathy; Pasquale, Bert; McMann, Joseph; Hagopian, John; Dominguez, Margaret; Gong, Qian; Morey, Peter

2016-01-01

The Cycle 5 design baseline for the Wide-Field Infrared Survey Telescope Astrophysics Focused Telescope Assets (WFIRSTAFTA) instrument includes a single wide-field channel (WFC) instrument for both imaging and slit-less spectroscopy. The only routinely moving part during scientific observations for this wide-field channel is the element wheel (EW) assembly. This filter-wheel assembly will have 8 positions that will be populated with 6 bandpass filters, a blank position, and a Grism that will consist of a three-element assembly to disperse the full field with an undeviated central wavelength for galaxy redshift surveys. All filter elements in the EW assembly will be made out of fused silica substrates (110 mm diameter) that will have the appropriate bandpass coatings according to the filter designations (Z087, Y106, J129, H158, F184, W149 and Grism). This paper presents and discusses the performance (including spectral transmission and reflectedtransmitted wavefront error measurements) of a subset of bandpass filter coating prototypes that are based on the WFC instrument filter compliment. The bandpass coating prototypes that are tested in this effort correspond to the Z087, W149, and Grism filter elements. These filter coatings have been procured from three different vendors to assess the most challenging aspects in terms of the in-band throughput, out of band rejection (including the cut-on and cutoff slopes), and the impact the wavefront error distortions of these filter coatings will have on the imaging performance of the de-field channel in the WFIRSTAFTA observatory.

A direct link between chorus emissions and pulsating aurora on timescales from milliseconds to minutes: A case study at subauroral latitudes

DOE PAGES

Ozaki, Mitsunori; Yagitani, Satoshi; Sawai, Kaoru; ...

2015-11-27

A correlation was observed between chorus emissions and pulsating aurora (PA) from observations at Athabasca (L ≈ 4.3) in Canada at 9:00–9:20 UT on 7 February 2013, using an electron multiplying charge-coupled device camera and a VLF loop antenna with sampling rates of 110 Hz and 100 kHz, respectively. Pulsating aurora having a quasiperiodic variation in luminosity and a few hertz modulation was observed together with chorus emissions consisting of a group of successive rising-tone elements. The repetition period and modulation frequency of the PA are in good agreement with those of the modulated chorus. After 9:11 UT, the temporalmore » features of the aurora became aperiodic PA of indistinct modulation. Simultaneously, the rising-tone chorus turned into chorus emissions consisting of numerous rising-tone elements. The equatorial geomagnetic field inhomogeneity calculated using the Tsyganenko 2002 model shows a decreasing trend during the period. This result is consistent with nonlinear wave growth theory having a small geomagnetic field inhomogeneity, which contributes to a decrease in the threshold amplitude to trigger discrete chorus elements. As a result, these observations show a close connection between chorus emissions and PA on timescales from milliseconds for generation of discrete chorus elements on the microphysics of wave-particle interaction to minutes for the variations of the geomagnetic field inhomogeneity related with the substorm activity.« less

CP110 exhibits novel regulatory activities during centriole assembly in Drosophila

PubMed Central

Franz, Anna; Roque, Hélio; Saurya, Saroj; Dobbelaere, Jeroen

2013-01-01

CP110 is a conserved centriole protein implicated in the regulation of cell division, centriole duplication, and centriole length and in the suppression of ciliogenesis. Surprisingly, we report that mutant flies lacking CP110 (CP110Δ) were viable and fertile and had no obvious defects in cell division, centriole duplication, or cilia formation. We show that CP110 has at least three functions in flies. First, it subtly influences centriole length by counteracting the centriole-elongating activity of several centriole duplication proteins. Specifically, we report that centrioles are ∼10% longer than normal in CP110Δ mutants and ∼20% shorter when CP110 is overexpressed. Second, CP110 ensures that the centriolar microtubules do not extend beyond the distal end of the centriole, as some centriolar microtubules can be more than 50 times longer than the centriole in the absence of CP110. Finally, and unexpectedly, CP110 suppresses centriole overduplication induced by the overexpression of centriole duplication proteins. These studies identify novel and surprising functions for CP110 in vivo in flies. PMID:24297749

On Surface Losses in Direct Metal Laser Sintering Printed Millimeter and Submillimeter Waveguides

NASA Astrophysics Data System (ADS)

Holmberg, Max; Dancila, Dragos; Rydberg, Anders; Hjörvarsson, Björgvin; Jansson, Ulf; Marattukalam, Jithin James; Johansson, Niklas; Andersson, Joakim

2018-02-01

Different lengths of WR3 (220-330 GHz) and WR10 (75-110 GHz) waveguides are fabricated through direct metal laser sintering (DMLS). The losses in these waveguides are measured and modelled using the Huray surface roughness model. The losses in WR3 are around 0.3 dB/mm and in WR10 0.05 dB/mm. The Huray equation model is accounting relatively good for the attenuation in the WR10 waveguide but deviates more in the WR3 waveguide. The model is compared to finite element simulations of the losses assuming an approximate surface structure similar to the resulting one from the DMLS process.

On Surface Losses in Direct Metal Laser Sintering Printed Millimeter and Submillimeter Waveguides

NASA Astrophysics Data System (ADS)

Holmberg, Max; Dancila, Dragos; Rydberg, Anders; Hjörvarsson, Björgvin; Jansson, Ulf; Marattukalam, Jithin James; Johansson, Niklas; Andersson, Joakim

2018-06-01

Different lengths of WR3 (220-330 GHz) and WR10 (75-110 GHz) waveguides are fabricated through direct metal laser sintering (DMLS). The losses in these waveguides are measured and modelled using the Huray surface roughness model. The losses in WR3 are around 0.3 dB/mm and in WR10 0.05 dB/mm. The Huray equation model is accounting relatively good for the attenuation in the WR10 waveguide but deviates more in the WR3 waveguide. The model is compared to finite element simulations of the losses assuming an approximate surface structure similar to the resulting one from the DMLS process.

HIGH-RESOLUTION FOURIER TRANSFORM SPECTROSCOPY OF Nb i IN THE NEAR-INFRARED

DOE Office of Scientific and Technical Information (OSTI.GOV)

Er, A.; Güzelçimen, F.; Başar, Gö.

In this study, a Fourier Transform spectrum of Niobium (Nb) is investigated in the near-infrared spectral range from 6000 to 12,000 cm{sup −1} (830–1660 nm). The Nb spectrum is produced using a hollow cathode discharge lamp in an argon atmosphere. Both Nb and Ar spectral lines are visible in the spectrum. A total of 110 spectral lines are assigned to the element Nb. Of these lines, 90 could be classified as transitions between known levels of atomic Nb. From these classified Nb i transitions, 27 have not been listed in literature previously. Additionally, 8 lines are classified for the firstmore » time.« less

KSC-03pd0764

NASA Image and Video Library

2003-03-20

KENNEDY SPACE CENTER, Fla. - With cables released, this Mars Exploration Rover sits on the floor of the Payload Hazardous Servicing Facility. Processing of the rovers, cruise stage, lander and heat shield elements is ongoing. Set to launch in 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The rovers will be identical to each other, but will land at different regions of Mars. The first rover has a launch window opening May 30, and the second rover a window opening June 25, 2003.

KSC-03pd0765

NASA Image and Video Library

2003-03-20

KENNEDY SPACE CENTER, Fla. - With cables released, this Mars Exploration Rover (MER) sits on the floor of the Payload Hazardous Servicing Facility. Processing of the rovers, cruise stage, lander and heat shield elements is ongoing. Set to launch in 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The rovers will be identical to each other, but will land at different regions of Mars. The first rover has a launch window opening May 30, and the second rover a window opening June 25, 2003.

KSC-03pd0762

NASA Image and Video Library

2003-03-20

KENNEDY SPACE CENTER, Fla. - A worker in the Payload Hazardous Servicing Facility makes adjustments on one of the Mars Exploration Rovers (MER). Processing of the rovers, cruise stage, lander and heat shield elements is ongoing. Set to launch in 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The rovers will be identical to each other, but will land at different regions of Mars. The first rover has a launch window opening May 30, and the second rover a window opening June 25, 2003.

KSC-03pd0761

NASA Image and Video Library

2003-03-20

KENNEDY SPACE CENTER, Fla. - Workers in the Payload Hazardous Servicing Facility look over one of the Mars Exploration Rovers (MER). Processing of the rovers, cruise stage, lander and heat shield elements is ongoing. Set to launch in 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The rovers will be identical to each other, but will land at different regions of Mars. The first rover has a launch window opening May 30, and the second rover a window opening June 25, 2003.

KSC-03pd0758

NASA Image and Video Library

2003-03-20

KENNEDY SPACE CENTER, FLA. - One of the Mars Exploration Rovers (MER) sits on a stand in the Payload Hazardous Servicing Facility. Processing of the rovers, cruise stage, lander and heat shield elements is ongoing. Set to launch in 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The rovers will be identical to each other, but will land at different regions of Mars. The first rover has a launch window opening May 30, and the second rover a window opening June 25, 2003.

Nationwide residues of mercury, lead, cadmium, arsenic, and selenium in starlings, 1973

USGS Publications Warehouse

White, D.H.; Bean, J.R.; Longcore, J.R.

1977-01-01

Starlings (Sturnus vulgaris) collected in 1973 at 51 sites throughout the continental United States were analyzed for mercury, lead, cadmium, arsenic, and selenium. All samples contained detectable levels of these elements. In general, residues were low: mercury residues ranged from <0.01 to 0.20 ppm: lead, from <0.10 10 3.20 ppm: cadmium, from <0.05 to 0.20 ppm: arsenic, from <0.05 to 1.40 ppm: and selenium, from 0.10 to 1.10 ppm. There was a significant overall decline in mercury and lead residues in starlings since 1971, and a significant increase in arsenic residues. Lead residues were significantly higher in starlings from urban areas than from rural areas.

ELECTRIC IMPEDANCE OF ASTERIAS EGGS

PubMed Central

Cole, Kenneth S.; Cole, Robert H.

1936-01-01

The alternating current resistance and capacity of suspensions of unfertilized eggs of Asterias forbesi have been measured at frequencies from one thousand to sixteen million cycles per second. The plasma membrane of the egg has a static capacity of 1.10µf/cm.2 which is practically independent of frequency. The suspensions show a capacity dependent on frequency at low frequencies which may be attributable to surface conductance. The specific resistance of the cytoplasm is between 136 and 225 ohm cm. (4 to 7 times sea water), indicating a relatively high concentration of non-electrolytes. At frequencies above one million cycles there is definite evidence of another element of which the nucleus is presumably a part. PMID:19872951

Development of Planar Optics for an Optical Tracking Sensor

NASA Astrophysics Data System (ADS)

Kawano, Hiroyuki; Sasagawa, Tomohiro

1998-10-01

An optical tracking sensor for large-capacity flexible disk drive (FDD) is demonstrated. The passive optics is compact and lightweight (5.4 mm length×3.6 mm width×1.2 mm height in size and 18 mg weight). It comprises all passive optical elements necessary for optical tracking, e.g., a focusing lens, a three-beam grating, an aperture and a beam splitter grating. Three beams were focused to a predetermined spot size of 13 µm at designed intervals of 110 µm on a disk surface and the reflected beams were successfully guided to photodiodes. This confirms that the application of the planar optical technique is very useful for realizing a compact and light optical sensor.

Adsorption and diffusion of atomic oxygen and sulfur at pristine and doped Ni surfaces with implications for stress corrosion cracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexandrov, Vitaly; Sushko, Maria L.; Schreiber, Daniel K.

A density-functional-theory modeling study of atomic oxygen/sulfur adsorption and diffusion at pristine and doped Ni(111) and (110) surfaces is presented. We find that oxygen and sulfur feature comparable adsorption energies over the same surface sites, however, the surface diffusion of sulfur is characterized by an activation barrier about one half that of oxygen. Calculations with different alloying elements at Ni surfaces show that Cr strongly enhances surface binding of both species in comparison to Al. These results in combination with previous modeling studies help explain the observed differences in selective grain boundary oxidation mechanisms of Ni-Cr and Ni-Al alloys.

P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse

PubMed Central

Iyengar, Sunil; Clear, Andrew; Bödör, Csaba; Maharaj, Lenushka; Lee, Abigail; Calaminici, Maria; Matthews, Janet; Iqbal, Sameena; Auer, Rebecca; Joel, Simon

2013-01-01

Phosphoinositide-3 kinase (PI3K) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis, but early-phase studies of the PI3K p110δ inhibitor GS-1101 have reported inferior responses in MCL compared with other non-Hodgkin lymphomas. Because the relative importance of the class IA PI3K isoforms p110α, p110β, and p110δ in MCL is not clear, we studied expression of these isoforms and assessed their contribution to PI3K signaling in this disease. We found that although p110δ was highly expressed in MCL, p110α showed wide variation and expression increased significantly with relapse. Loss of phosphatase and tensin homolog expression was found in 16% (22/138) of cases, whereas PIK3CA and PIK3R1 mutations were absent. Although p110δ inhibition was sufficient to block B-cell receptor–mediated PI3K activation, combined p110α and p110δ inhibition was necessary to abolish constitutive PI3K activation. In addition, GDC-0941, a predominantly p110α/δ inhibitor, was significantly more active compared with GS-1101 against MCL cell lines and primary samples. We found that a high PIK3CA/PIK3CD ratio identified a subset of primary MCLs resistant to GS-1101 and this ratio increased significantly with relapse. These findings support the use of dual p110α/p110δ inhibitors in MCL and suggest a role for p110α in disease progression. PMID:23341541

3 CFR - Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims Protection Act of 2000, as Amended Presidential Documents Other Presidential Documents Memorandum of July 29, 2013 Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims...

3 CFR - Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 3 The President 1 2013-01-01 2013-01-01 false Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking Victims Protection Act of 2000, as Amended Presidential Documents Other Presidential Documents Memorandum of February 3, 2012 Delegation of Authority Pursuant to Sections 110(d)(4) and 110(f) of the Trafficking...

Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin.

PubMed

Feltus, F A; Groner, B; Melner, M H

1999-07-01

Altered PRL levels are associated with infertility in women. Molecular targets at which PRL elicits these effects have yet to be determined. These studies demonstrate transcriptional regulation by PRL of the gene encoding the final enzymatic step in progesterone biosynthesis: 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase (3beta-HSD). A 9/9 match with the consensus Stat5 response element was identified at -110 to -118 in the human Type II 3beta-HSD promoter. 3beta-HSD chloramphenicol acetyltransferase (CAT) reporter constructs containing either an intact or mutated Stat5 element were tested for PRL activation. Expression vectors for Stat5 and the PRL receptor were cotransfected with a -300 --> +45 3beta-HSD CAT reporter construct into HeLa cells, which resulted in a 21-fold increase in reporter activity in the presence of PRL. Promoter activity showed an increased response with a stepwise elevation of transfected Stat5 expression or by treatment with increasing concentrations of PRL (max, 250 ng/ml). This effect was dramatically reduced when the putative Stat5 response element was removed by 5'-deletion of the promoter or by the introduction of a 3-bp mutation into critical nucleotides in the element. Furthermore, 32P-labeled promoter fragments containing the Stat5 element were shifted in electrophoretic mobility shift assay experiments using nuclear extracts from cells treated with PRL, and this complex was supershifted with antibodies to Stat5. These results demonstrate that PRL has the ability to regulate expression of a key human enzyme gene (type II 3beta-HSD) in the progesterone biosynthetic pathway, which is essential for maintaining pregnancy.

Are additional trace elements necessary in total parenteral nutrition for patients with esophageal cancer receiving cisplatin-based chemotherapy?

PubMed

Akutsu, Yasunori; Kono, Tsuguaki; Uesato, Masaya; Hoshino, Isamu; Murakami, Kentaro; Fujishiro, Takeshi; Imanishi, Shunsuke; Endo, Satoshi; Toyozumi, Takeshi; Matsubara, Hisahiro

2012-12-01

It is known that cisplatin induces the excretion of zinc from the urine and thereby reduces its serum concentration. However, the fluctuation of these trace elements during or after cisplatin-based chemotherapy has not been evaluated. To answer this question, we performed a clinical study in esophageal cancer patients undergoing cisplatin-based chemotherapy. Eighteen patients with esophageal cancer who were not able to swallow food or water orally due to complete stenosis of the esophagus were evaluated. The patients were divided into a control group [total parenteral nutrition (TPN) alone for 28 days, ten cases] and an intervention group (TPN with additional trace elements for 28 days, eight cases). The serum concentrations of zinc, iron, copper, manganese, triiodothyronin (T3), and thyroxin (T4), as alternative indicators of iodine, were measured on days 0, 14, and 28 of treatment, and statistically analyzed on day 28. In the control group, the serum concentration of copper was significantly decreased from 135.4 (day 0) to 122.1 μg/ml (day 14), and finally to 110.6 μg/ml (day 28, p = 0.015). The concentration of manganese was also significantly decreased from 1.34 (day 0) to 1.17 μg/ml (day 14) and finally to 1.20 (day 28, p = 0.049). The levels of zinc, iron, T3, and T4 were not significantly changed. In the intervention group, the supplementation with trace elements successfully prevented these decreases in their concentrations. TPN with supplementary trace elements is preferable and recommended for patients who are undergoing chemotherapy in order to maintain the patients' nutrient homeostasis.

Determination of 18 kinds of trace impurities in the vanadium battery grade vanadyl sulfate by ICP-OES

NASA Astrophysics Data System (ADS)

Yong, Cheng

2018-03-01

The method that direct determination of 18 kinds of trace impurities in the vanadium battery grade vanadyl sulfate by inductively coupled plasma atomic emission spectrometry (ICP-OES) was established, and the detection range includes 0.001% ∼ 0.100% of Fe, Cr, Ni, Cu, Mn, Mo, Pb, As, Co, P, Ti, Zn and 0.005% ∼ 0.100% of K, Na, Ca, Mg, Si, Al. That the influence of the matrix effects, spectral interferences and background continuum superposition in the high concentrations of vanadium ions and sulfate coexistence system had been studied, and then the following conclusions were obtained: the sulfate at this concentration had no effect on the determination, but the matrix effects or continuous background superposition which were generated by high concentration of vanadium ions had negative interference on the determination of potassium and sodium, and it produced a positive interference on the determination of the iron and other impurity elements, so that the impacts of high vanadium matrix were eliminated by the matrix matching and combining synchronous background correction measures. Through the spectral interference test, the paper classification summarized the spectral interferences of vanadium matrix and between the impurity elements, and the analytical lines, the background correction regions and working parameters of the spectrometer were all optimized. The technical performance index of the analysis method is that the background equivalent concentration -0.0003%(Na)~0.0004%(Cu), the detection limit of the element is 0.0001%∼ 0.0003%, RSD<10% when the element content is in the range from 0.001% to 0.007%, RSD< 20% even if the element content is in the range from 0.0001% to 0.001% that is beyond the scope of the method of detection, recoveries is 91.0% ∼ 110.0%.

10 CFR 110.101 - Filing and service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Filing and service. 110.101 Section 110.101 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Hearings § 110.101 Filing and service. Filing and service of hearing documents shall be pursuant to § 110.89. ...

Characterization, photophysical and DFT calculation study on 2-(2,4-difluorophenyl)-1-(4-methoxyphenyl)-1H-imidazo[4,5-f][1,10]phenanthroline ligand.

PubMed

Jayabharathi, Jayaraman; Thanikachalam, Venugopal; Venkatesh Perumal, Marimuthu

2012-09-01

The synthesized imidazole derivative 2-(2,4-difluorophenyl)-1-(4-methoxyphenyl)-1H-imidazo[4,5-f][1,10] phenanthroline (dfpmpip) has been characterized using IR, mass, (1)H, (13)C NMR and elemental analysis. The photophysical properties of dfpmpip have been studied using UV-visible and fluorescence spectroscopy in different solvents. The solvent effect on the absorption and fluorescence bands has been analyzed by a multi-component linear regression. Theoretically calculated bond lengths, bond angles and dihedral angles are found to be slightly higher than that of X-ray Diffraction (XRD) values of its parent compound. The charge distribution has been calculated from the atomic charges by non-linear optical (NLO) and natural bond orbital (NBO) analysis. Since the synthesized imidazole derivative has the largest μ(g)β(0) value, the reported imidazole can be used as potential NLO material. The energies of the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels and the molecular electrostatic potential (MEP) energy surface studies evidenced the existence of intramolecular charge transfer (ICT) within the molecule. Theoretical calculations regarding the chemical potential (μ), hardness (η) and electrophilicity index (ω) have also been calculated. Copyright © 2012 Elsevier B.V. All rights reserved.

Silicon chemistry in the mesosphere and lower thermosphere

PubMed Central

Gómez‐Martín, Juan Carlos; Feng, Wuhu; Janches, Diego

2016-01-01

Abstract Silicon is one of the most abundant elements in cosmic dust, and meteoric ablation injects a significant amount of Si into the atmosphere above 80 km. In this study, a new model for silicon chemistry in the mesosphere/lower thermosphere is described, based on recent laboratory kinetic studies of Si, SiO, SiO2, and Si+. Electronic structure calculations and statistical rate theory are used to show that the likely fate of SiO2 is a two‐step hydration to silicic acid (Si(OH)4), which then polymerizes with metal oxides and hydroxides to form meteoric smoke particles. This chemistry is then incorporated into a whole atmosphere chemistry‐climate model. The vertical profiles of Si+ and the Si+/Fe+ ratio are shown to be in good agreement with rocket‐borne mass spectrometric measurements between 90 and 110 km. Si+ has consistently been observed to be the major meteoric ion around 110 km; this implies that the relative injection rate of Si from meteoric ablation, compared to metals such as Fe and Mg, is significantly larger than expected based on their relative chondritic abundances. Finally, the global abundances of SiO and Si(OH)4 show clear evidence of the seasonal meteoric input function, which is much less pronounced in the case of other meteoric species. PMID:27668138

Methylation guide RNA evolution in archaea: structure, function and genomic organization of 110 C/D box sRNA families across six Pyrobaculum species.

PubMed

Lui, Lauren M; Uzilov, Andrew V; Bernick, David L; Corredor, Andrea; Lowe, Todd M; Dennis, Patrick P

2018-05-16

Archaeal homologs of eukaryotic C/D box small nucleolar RNAs (C/D box sRNAs) guide precise 2'-O-methyl modification of ribosomal and transfer RNAs. Although C/D box sRNA genes constitute one of the largest RNA gene families in archaeal thermophiles, most genomes have incomplete sRNA gene annotation because reliable, fully automated detection methods are not available. We expanded and curated a comprehensive gene set across six species of the crenarchaeal genus Pyrobaculum, particularly rich in C/D box sRNA genes. Using high-throughput small RNA sequencing, specialized computational searches and comparative genomics, we analyzed 526 Pyrobaculum C/D box sRNAs, organizing them into 110 families based on synteny and conservation of guide sequences which determine methylation targets. We examined gene duplications and rearrangements, including one family that has expanded in a pattern similar to retrotransposed repetitive elements in eukaryotes. New training data and inclusion of kink-turn secondary structural features enabled creation of an improved search model. Our analyses provide the most comprehensive, dynamic view of C/D box sRNA evolutionary history within a genus, in terms of modification function, feature plasticity, and gene mobility.

Thick target total bremsstrahlung spectra of lead compounds in the photon energy region 1-10keV by 90Sr beta particles.

PubMed

Sharma, Suhansar Jit; Singh, Tajinder; Singh, Doordarshi; Singh, Amrit; Dhaliwal, A S

2017-12-01

Total bremsstrahlung spectral photon distribution generated in thick targets of lead compounds Pb(CH 3 COO) 2 ·3H 2 O, Pb(NO 3 ) 2 and PbCl 2 by 90 Sr beta particles has been investigated theoretically and experimentally in the photon energy region 1-10keV. The experimental results are compared with the theoretical models describing ordinary bremsstrahlung and the theoretical model which includes polarization bremsstrahlung into ordinary bremsstrahlung, in stripped approximation. It is observed that the experimental results show better agreement with the model which describes bremsstrahlung in stripped approximation in the energy range 3-10keV. However, the results show positive deviation in the photon energy region of 1-3keV. Further, it has been found that there is a continuous decrease of polarization bremsstrahlung contribution into ordinary bremsstrahlung in the formation of total bremsstrahlung spectra with increase in photon energy. The suppression of polarization bremsstrahlung has been observed due to the presence of large fraction of low Z elements in the compounds. The results clearly indicate that polarization bremsstrahlung plays an important role in the formation of total bremsstrahlung spectra in compounds in the studied energy region. Copyright © 2017 Elsevier Ltd. All rights reserved.

Size effects in MgO cube dissolution.

PubMed

Baumann, Stefan O; Schneider, Johannes; Sternig, Andreas; Thomele, Daniel; Stankic, Slavica; Berger, Thomas; Grönbeck, Henrik; Diwald, Oliver

2015-03-10

Stability parameters and dissolution behavior of engineered nanomaterials in aqueous systems are critical to assess their functionality and fate under environmental conditions. Using scanning electron microscopy, transmission electron microscopy, and X-ray diffraction, we investigated the stability of cubic MgO particles in water. MgO dissolution proceeding via water dissociation at the oxide surface, disintegration of Mg(2+)-O(2-) surface elements, and their subsequent solvation ultimately leads to precipitation of Mg(OH)2 nanosheets. At a pH ≥ 10, MgO nanocubes with a size distribution below 10 nm quantitatively dissolve within few minutes and convert into Mg(OH)2 nanosheets. This effect is different from MgO cubes originating from magnesium combustion in air. With a size distribution in the range 10 nm ≤ d ≤ 1000 nm they dissolve with a significantly smaller dissolution rate in water. On these particles water induced etching generates (110) faces which, above a certain face area, dissolve at a rate equal to that of (100) planes.1 The delayed solubility of microcrystalline MgO is attributed to surface hydroxide induced self-inhibition effects occurring at the (100) and (110) microplanes. The present work underlines the importance of morphology evolution and surface faceting of engineered nanomaterials particles during their dissolution.

Gastric Inhibitory Peptide Controls Adipose Insulin Sensitivity via Activation of cAMP-response Element-binding Protein and p110β Isoform of Phosphatidylinositol 3-Kinase*

PubMed Central

Mohammad, Sameer; Ramos, Lavoisier S.; Buck, Jochen; Levin, Lonny R.; Rubino, Francesco; McGraw, Timothy E.

2011-01-01

Gastric inhibitory peptide (GIP) is an incretin hormone secreted in response to food intake. The best known function of GIP is to enhance glucose-dependent insulin secretion from pancreatic β-cells. Extra-pancreatic effects of GIP primarily occur in adipose tissues. Here, we demonstrate that GIP increases insulin-dependent translocation of the Glut4 glucose transporter to the plasma membrane and exclusion of FoxO1 transcription factor from the nucleus in adipocytes, establishing that GIP has a general effect on insulin action in adipocytes. Stimulation of adipocytes with GIP alone has no effect on these processes. Using pharmacologic and molecular genetic approaches, we show that the effect of GIP on adipocyte insulin sensitivity requires activation of both the cAMP/protein kinase A/CREB signaling module and p110β phosphoinositol-3′ kinase, establishing a novel signal transduction pathway modulating insulin action in adipocytes. This insulin-sensitizing effect is specific for GIP because isoproterenol, which elevates adipocyte cAMP and activates PKA/CREB signaling, does not affect adipocyte insulin sensitivity. The insulin-sensitizing activity points to a more central role for GIP in intestinal regulation of peripheral tissue metabolism, an emerging feature of inter-organ communication in the control of metabolism. PMID:22027830

Silicon Chemistry in the Mesosphere and Lower Thermosphere

NASA Technical Reports Server (NTRS)

Plane, John M. C.; Gomez-Martin, Juan Carlos; Feng, Wuhu; Janches, Diego

2016-01-01

Silicon is one of the most abundant elements in cosmic dust, and meteoric ablation injects a significant amount of Si into the atmosphere above 80 km. In this study, a new model for silicon chemistry in the mesosphere lower thermosphere is described, based on recent laboratory kinetic studies of Si, SiO,SiO2, and S(exp +). Electronic structure calculations and statistical rate theory are used to show that the likely fate of SiO2 is a two-step hydration to silicic acid (Si(OH)4), which then polymerizes with metal oxides and hydroxides to form meteoric smoke particles. This chemistry is then incorporated into a whole atmosphere chemistry-climate model. The vertical profiles of Si+ and the Si(exp +)Fe(exp +) ratio are shown to be in good agreement with rocket-borne mass spectrometric measurements between 90 and 110 km. Si(exp +) has consistently been observed to be the major meteoric ion around 110 km; this implies that the relative injection rate of Si from meteoric ablation, compared to metals such as Fe and Mg, is significantly larger than expected based on the irrelative chondritic abundances. Finally, the global abundances of SiO and Si(OH)4 show clear evidence of the seasonal meteoric input function, which is much less pronounced in the case of other meteoric species.

Glass precursor approach to high-temperature superconductors

NASA Technical Reports Server (NTRS)

Bansal, Narottam P.

1992-01-01

The available studies on the synthesis of high T sub c superconductors (HTS) via the glass precursor approach were reviewed. Melts of the Bi-Sr-Ca-Cu-O system as well as those doped with oxides of some other elements (Pb, Al, V, Te, Nb, etc.) could be quenched into glasses which, on further heat treatments under appropriate conditions, crystallized into the superconducting phase(s). The nature of the HTS phase(s) formed depends on the annealing temperature, time, atmosphere, and the cooling rate and also on the glass composition. Long term annealing was needed to obtain a large fraction of the 110 K phase. The high T sub c phase did not crystallize out directly from the glass matrix, but was preceded by the precipitation of other phases. The 110 K HTS was produced at high temperatures by reaction between the phases formed at lower temperatures resulting in multiphase material. The presence of a glass former such as B2O3 was necessary for the Y-Ba-Cu-O melt to form a glass on fast cooling. A discontinuous YBa2Cu3O(7-delta) HTS phase crystallized out on heat treatment of this glass. Attempts to prepare Tl-Ba-Ca-Cu-O system in the glassy state were not successful.

Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway

PubMed Central

Ma, Benting; Zhu, Junjie; Tan, Juan; Mao, Yulei; Tang, Lingyun; Shen, Chunling; Zhang, Hongxing; Kuang, Ying; Fei, Jian; Yang, Xiao; Wang, Zhugang

2017-01-01

Hepatocarcinogenesis is a complex process that includes pronounced necroinflammation, unregulated hepatocyte damage, subsequent extensive fibrosis, and carcinogenesis. GPR110 was an adhesion G protein-coupled receptor. Analysis of the expression pattern of Gpr110 in mice displayed that Gpr110 was expressed highly in liver, implicating the tissue compartments where Gpr110 could execute its functions, the role of Gpr110 in the physiological and pathological state of liver remains unclear. Based on a Gpr110 knockout mouse model, we evaluated the role of Gpr110 in hepatocarcinogenesis by using a carbon tetrachloride (CCl4)-induced liver injury and fibrosis model, as well as diethylnitrosamine (DEN) plus CCl4-induced liver cancer model. In this study, we found subdued chronic liver injury, reduced compensatory proliferation, lower liver fibrosis, but enhanced inflammation occurred in Gpr110-/- mice during CCl4 challenge. In addition, Gpr110-/- mice were resistant to liver tumorigenesis induced by DEN plus CCl4 injection. Molecular mechanisms underlying these differences correlated with augmented activation of the IL-6/STAT3 pathway, which exerted hepatoprotective effects during liver damage, fibrosis, and oncogenesis in Gpr110-/- mice. Furthermore, pharmacological inhibition of the activation of the IL-6/STAT3 pathway enhanced hepatic fibrosis and promoted DEN plus CCl4-induced carcinogenesis in Gpr110-/- mice. In summary, absence of Gpr110 decelerates liver fibrosis/cirrhosis progressing into tumorigenesis, due to strengthening activation of the IL-6/STAT3 pathway, leading to a weaker liver injury and fibrosis microenvironment. It is indicated that targeting Gpr110 and activating the IL-6/STAT3 pathway may be considered to be preventive methods for some cirrhosis transition. PMID:28401002

Oxidative potential of on-road fine particulate matter (PM2.5) measured on major freeways of Los Angeles, CA, and a 10-year comparison with earlier roadside studies

NASA Astrophysics Data System (ADS)

Shirmohammadi, Farimah; Wang, Dongbin; Hasheminassab, Sina; Verma, Vishal; Schauer, James J.; Shafer, Martin M.; Sioutas, Constantinos

2017-01-01

This study describes on-road measurements of fine particulate matter (PM2.5) using a mobile instrumentation platform to assess the chemical composition and oxidative potential of PM2.5, using the dithiothreitol (DTT) assay, over three representative roadways in the Los Angeles Basin: the I-110 and I-710 freeways, the Wilshire/Sunset boulevards as well as the main campus of the University of Southern California (USC), used as a reference urban background site. Samples were chemically analyzed for elemental carbon (EC), organic carbon (OC), polycyclic aromatic hydrocarbons (PAHs) and 50 elements. The cumulative mass fraction of the measured PAHs was highest on the freeways (0.16 ± 0.01 and 0.15 ± 0.01 ng/μg PM, on I-110 and I-710, respectively); which on average was 3 and 3.3-fold higher than at Wilshire/Sunset and USC site, respectively. Mass fractions of Ba, Cr, Cu, Mn, Ni, Pb, Sb and Zn, tracers of vehicular abrasion, were 3.8 ± 0.8 times higher on both freeways in comparison to Wilshire/Sunset. The observed intrinsic (normalized per PM mass) DTT activity was greatest on freeways, averaging 30.13 ± 3.15 nmol/min mg PM and being roughly 1.9 and 2.1 times higher than the values obtained at Wilshire/Sunset and USC, respectively. Furthermore, comparison of our results with previous on-road and roadside studies conducted in the last decade in Los Angeles indicated an overall reduction in the contribution of carbonaceous species and PAHs (important tracers of exhaust emissions) to PM mass, especially on I-710 freeway with the higher heavy-duty diesel vehicle fraction, indicating the effectiveness of diesel vehicle emissions control policies implemented in recent years in California. In contrast, greater contributions of certain groups of metals and trace elements that are indicators of non-tailpipe emissions compared to previous studies provide evidence on the increasing importance of non-tailpipe emissions to the oxidative potential of on-road PM2.5 as vehicular exhaust emissions becomes cleaner. This finding was also reflected in the increased levels of on-road DTT activity by factors of 1.4-1.5 in comparison to the DTT activity of vehicular emissions estimated in previous dynamometer studies.

46 CFR 110.25-3 - Procedure for submitting plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Procedure for submitting plans. 110.25-3 Section 110.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Plan Submittal § 110.25-3 Procedure for submitting plans. (a) The plans required by § 110.25-1...

46 CFR 110.25-3 - Procedure for submitting plans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Procedure for submitting plans. 110.25-3 Section 110.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Plan Submittal § 110.25-3 Procedure for submitting plans. (a) The plans required by § 110.25-1...

46 CFR 110.25-3 - Procedure for submitting plans.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Procedure for submitting plans. 110.25-3 Section 110.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Plan Submittal § 110.25-3 Procedure for submitting plans. (a) The plans required by § 110.25-1...

46 CFR 110.25-3 - Procedure for submitting plans.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Procedure for submitting plans. 110.25-3 Section 110.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Plan Submittal § 110.25-3 Procedure for submitting plans. (a) The plans required by § 110.25-1...

46 CFR 110.25-3 - Procedure for submitting plans.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Procedure for submitting plans. 110.25-3 Section 110.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Plan Submittal § 110.25-3 Procedure for submitting plans. (a) The plans required by § 110.25-1...

11 CFR 110.17 - Price index increase.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Price index increase. 110.17 Section 110.17... PROHIBITIONS § 110.17 Price index increase. (a) Price index increases for party committee expenditure... 11 CFR 109.32 and 110.8 shall be increased by the percent difference between the price index, as...

Air-Coupled Ultrasonic Receivers with High Electromechanical Coupling PMN-32%PT Strip-Like Piezoelectric Elements

PubMed Central

Kazys, Rymantas J.; Sliteris, Reimondas; Sestoke, Justina

2017-01-01

For improvement of the efficiency of air-coupled ultrasonic transducers PMN-32%PT piezoelectric crystals which possess very high piezoelectric properties may be used. The electromechanical coupling factor of such crystals for all main vibration modes such as the thickness extension and transverse extension modes is more than 0.9. Operation of ultrasonic transducers with such piezoelectric elements in transmitting and receiving modes is rather different. Therefore, for transmission and reception of ultrasonic signals, separate piezoelectric elements with different dimensions must be used. The objective of this research was development of novel air-coupled ultrasonic receivers with PMN-32%PT strip-like piezoelectric elements vibrating in a transverse-extension mode with electromechanically controlled operation and suitable for applications in ultrasonic arrays. Performance of piezoelectric receivers made of the PMN-32%PT strip-like elements vibrating in this mode may be efficiently controlled by selecting geometry of the electrodes covering side surfaces of the piezoelectric element. It is equivalent to introduction of electromechanical damping which does not require any additional backing element. For this purpose; we have proposed the continuous electrodes to divide into two pairs of electrodes. The one pair is used to pick up the electric signal; another one is exploited for electromechanical damping. Two types of electrodes may be used—rectangular or non-rectangular—with a gap between them directed at some angle, usually 45°. The frequency bandwidth is wider (up to 9 kHz) in the case of non-rectangular electrodes. The strip-like acoustic matching element bonded to the tip of the PMN-32%PT crystal may significantly enhance the performance of the ultrasonic receiver. It was proposed to use for this purpose AIREX T10.110 rigid polymer foam, the acoustic impedance of which is close to the optimal value necessary for matching with air. It was found that in order to get a wide bandwidth the length of the matching strip should be selected not a quarter wavelength λ/4 at the antiresonance frequency but at lower frequency. It allowed achieving the frequency bandwidth (14–18)% with respect to the central frequency at −3 dB level. PMID:29035348

Three new insertion sequence elements ISLdl2, ISLdl3, and ISLdl4 in Lactobacillus delbrueckii: isolation, molecular characterization, and potential use for strain identification.

PubMed

Ravin, Victor; Alatossava, Tapani

2003-05-01

A group of new insertion sequence (IS) elements, ISLdl2, ISLdl3, and ISLdl4, from Lactobacillus delbrueckii subsp. lactis ATCC 15808 was isolated, characterized, and used for strain identification together with ISLdl1, recently characterized as an L. delbrueckii IS element belonging to the ISL3 family. ISLdl2 was 1367 bp in size and had a 24 bp IR and an 8 bp DR. The single ORF of ISLdl2 encoded a protein of 392 aa similar to transposases of the IS256 family. ISLdl3 had a single ORF encoding a protein of 343 aa similar to transposases of the IS30 family. Finally, ISLdl4 had a single ORF encoding a protein of 406 aa and displayed homology to the transposases of the IS110 family. ISLdl4 was only slight different from ISL4 (Accession No. AY040213). ISLdl1, ISLdl2, and ISLdl4 were present in all of the 10 L. delbrueckii subsp. lactis and subsp. delbrueckii strains tested, as well as in three of the 11 L. delbrueckii subsp. bulgaricus strains tested. ISLdl3 was present only in four closely related strains of L. delbrueckii subsp. lactis. These IS elements were not observed in Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus helveticus, or Lactobacillus plantarum. A cluster of IS elements, ISLdl1, ISLdl2, ISLdl3, ISLdl4, and ISL6, was observed in L. delbrueckii subsp. lactis strain ATCC 15808. Within this cluster, ISLdl4 was inserted into ISLdl1 between the left IR and the start codon of ORF455, encoding a putative transposase. Most of the integration sites of the IS elements were strain-specific. We have observed that IS elements can migrate from one strain to another as integral parts of bacterial DNA by using phage LL-H as a vehicle. We demonstrate for the first time that inverse PCR and vectorette PCR methods with primers based on sequences of the IS elements could be used for identification of L. delbrueckii strains.

Assimilation efficiencies and turnover rates of trace elements in marine bivalves: A comparison of oysters, clams and mussels

USGS Publications Warehouse

Reinfelder, J.R.; Wang, W.-X.; Luoma, S. N.; Fisher, N.S.

1997-01-01

Assimilation efficiencies (AEs) and physiological turnover-rate constants (k) of six trace elements (Ag, Am, Cd, Co, Se, Zn) in four marine bivalves (Crassostrea virginica Gmelin,Macoma balthica Linnaeus, Mercenaria mercenaria Linnaeus, and Mytilus edulis Linnaeus) were measured in radiotracer-depuration experiments. Egestion rates of unassimilated elements were highest during the first 24 h of depuration and declined thereafter. Significant egestion of unassimilated Co, however, continued for up to 5 d in Macoma balthica,Mercenaria mercenaria and Mytilus edulis. With the exception of the extremely low values for110 mAg, 109Cd, and 65Zn in C. virginica, physiological turnover-rate constants (k) showed no general pattern of variation among elements, bivalve species or food types, and were relatively invariant. Values from  ≤0.001 to 0.1 d−1 were observed, but excluding those for Co, most values were  ≤0.04 d−1. In all four species, the AEs of Ag, Am, and Co were generally lower than those of Cd, Se, and Zn. The AEs of Ag, Cd, Se, and Zn in these bivalves are directly related to the proportion of each element in the cytoplasmic fraction of ingested phytoplankton, indicating that >80% of elements in a prey alga's cytoplasm was assimilated. C. virginica, Macoma balthica, and Mercenaria mercenaria assimilated ∼36% of the Ag and Cd associated with the non-cytoplasmic (membrane/organelle) fraction of ingested cells in addition to the cytoplasmic fraction. The ratio of AE:k, which is proportional to the consumer–prey trace-element bioaccumulation factor (concentration in consumer:concentration in prey) was generally greater for Cd, Se, and Zn than for Ag, Am, and Co. This ratio was lowest in Mytilus edulis, suggesting that this bivalve, the most widely employed organism in global biomonitoring, is relatively inefficient at accumulating important elements such as Ag, Cd, and Zn from ingested phytoplankton.

Air-Coupled Ultrasonic Receivers with High Electromechanical Coupling PMN-32%PT Strip-Like Piezoelectric Elements.

PubMed

Kazys, Rymantas J; Sliteris, Reimondas; Sestoke, Justina

2017-10-16

For improvement of the efficiency of air-coupled ultrasonic transducers PMN-32%PT piezoelectric crystals which possess very high piezoelectric properties may be used. The electromechanical coupling factor of such crystals for all main vibration modes such as the thickness extension and transverse extension modes is more than 0.9. Operation of ultrasonic transducers with such piezoelectric elements in transmitting and receiving modes is rather different. Therefore, for transmission and reception of ultrasonic signals, separate piezoelectric elements with different dimensions must be used. The objective of this research was development of novel air-coupled ultrasonic receivers with PMN-32%PT strip-like piezoelectric elements vibrating in a transverse-extension mode with electromechanically controlled operation and suitable for applications in ultrasonic arrays. Performance of piezoelectric receivers made of the PMN-32%PT strip-like elements vibrating in this mode may be efficiently controlled by selecting geometry of the electrodes covering side surfaces of the piezoelectric element. It is equivalent to introduction of electromechanical damping which does not require any additional backing element. For this purpose; we have proposed the continuous electrodes to divide into two pairs of electrodes. The one pair is used to pick up the electric signal; another one is exploited for electromechanical damping. Two types of electrodes may be used-rectangular or non-rectangular-with a gap between them directed at some angle, usually 45°. The frequency bandwidth is wider (up to 9 kHz) in the case of non-rectangular electrodes. The strip-like acoustic matching element bonded to the tip of the PMN-32%PT crystal may significantly enhance the performance of the ultrasonic receiver. It was proposed to use for this purpose AIREX T10.110 rigid polymer foam, the acoustic impedance of which is close to the optimal value necessary for matching with air. It was found that in order to get a wide bandwidth the length of the matching strip should be selected not a quarter wavelength λ/4 at the antiresonance frequency but at lower frequency. It allowed achieving the frequency bandwidth (14-18)% with respect to the central frequency at -3 dB level.

77 FR 14603 - Approval and Promulgation of Implementation Plans; Arkansas; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

...The EPA is partially approving and partially disapproving a revision to the Arkansas State Implementation Plan (SIP) intended to address the regional haze (RH) requirements of the Clean Air Act (CAA or Act). In addition, EPA is partially approving and partially disapproving the portion of the Arkansas Interstate Transport SIP submittal that addresses the visibility requirement of section 110(a)(2)(D)(i)(II) for the 1997 8-hour ozone and 1997 fine particulate matter (PM2.5) national ambient air quality standards (NAAQS) that the Arkansas SIP contain adequate provisions to prohibit emissions from interfering with measures required in another state to protect visibility. EPA is approving certain core elements of the RH SIP including: identification of affected Class I areas; determination of baseline and natural visibility conditions; determination of Uniform Rate of Progress (URP); reasonable progress goal (RPG) consultation and long term strategy (LTS) consultation; coordination of RH and reasonably attributable visibility impairment (RAVI); regional haze monitoring strategy and other SIP requirements under 40 CFR 51.308(d)(4); commitment to submit periodic regional haze SIP revisions and periodic progress reports describing progress towards the RPGs; commitment to make a determination of the adequacy of the existing SIP at the time a progress report is submitted; and consultation and coordination with Federal land managers (FLMs). EPA is partially approving and partially disapproving portions of other core elements of the SIP including: identification of best available retrofit technology (BART) eligible sources and subject to BART sources; requirements for BART; Chapter 15 of the Air Pollution Control and Ecology Commission (APCEC) Regulation No. 19, also known as the State's RH Rule; and the LTS. EPA is disapproving Arkansas's reasonable progress goals (RPGs) required under 40 CFR 51.308(d)(1). This action is being taken under section 110 and part C of the CAA.

49 CFR 110.110 - After-grant requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PUBLIC SECTOR TRAINING AND PLANNING GRANTS § 110.110 After-grant requirements. The Associate... must submit all financial, performance, and other reports required as a condition of the grant, within...

The PI3K Isoforms p110α and p110δ are Essential for Pre-B Cell Receptor Signaling and B Cell Development

PubMed Central

Ramadani, Faruk; Bolland, Daniel J.; Garcon, Fabien; Emery, Juliet L.; Vanhaesebroeck, Bart; Corcoran, Anne E.; Okkenhaug, Klaus

2013-01-01

B cell development is controlled by a series of checkpoints that ensure that the immunoglobulin (Ig)-encoding genes are assembled in frame to produce a functional B cell receptor (BCR) and antibodies. The BCR consists of Ig proteins in complex with the immunoreceptor tyrosine-based activation motif (ITAM)-containing Igα and Igβ chains. Whereas the activation of Src and Syk tyrosine kinases is essential for BCR signaling, the pathways that act downstream of these kinases are incompletely defined. Previous work has revealed a key role for the p110δ isoform of phosphoinositide 3-kinase (PI3K) in agonist-induced BCR signaling; however, early B cell development and mature B cell survival, which depend on tonic BCR signaling, are not substantially affected by a deficiency in p110δ. Here, we show that in the absence of p110δ, p110α, but not p110β, can compensate to promote early B cell development in the bone marrow and B cell survival in the spleen. In the absence of both p110α and p110δ activities, pre-BCR signaling fails to suppress the production of recombination-activating gene (Rag) protein and to promote developmental progression of B cell progenitors. By contrast, p110α does not contribute to agonist-induced BCR signaling. These studies indicate that either p110α or p110δ can mediate tonic signaling from the BCR, but that only p110δ can contribute to antigen-dependent activation of B cells. PMID:20699475

Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles

PubMed Central

Zhang, Jinsong; Taylor, Ethan W; Wan, Xiaochun; Peng, Dungeng

2012-01-01

Background Elemental selenium nanoparticles have emerged as a novel selenium source with the advantage of reduced risk of selenium toxicity. The present work investigated whether heat treatment affects the size, structure, and bioactivity of selenium nanoparticles. Methods and results After a one-hour incubation of solution containing 80 nm selenium particles in a 90°C water bath, the nanoparticles aggregated into larger 110 nm particles and nanorods (290 nm × 70 nm), leading to significantly reduced bioavailability and phase II enzyme induction in selenium-deficient mice. When a solution containing 40 nm selenium nanoparticles was treated under the same conditions, the nanoparticles aggregated into larger 72 nm particles but did not transform into nanorods, demonstrating that the thermostability of selenium nanoparticles is size-dependent, smaller selenium nanoparticles being more resistant than larger selenium nanoparticles to transformation into nanorods during heat treatment. Conclusion The present results suggest that temperature and duration of the heat process, as well as the original nanoparticle size, should be carefully selected when a solution containing selenium nanoparticles is added to functional foods. PMID:22359458

Profile and bioconcentration of minerals by King Bolete (Boletus edulis) from the Płocka Dale in Poland.

PubMed

Frankowska, Aneta; Ziółkowska, Joanna; Bielawski, Leszek; Falandysz, Jerzy

2010-01-01

This study aimed to provide basic data on the composition of metallic elements, including toxicologically important Cd and Hg, in popular and prized wild King Bolete mushrooms. We investigated the importance of soil substratum as a source of these metals. ICP-OES and CV-AAS were applied to determine the profile of Al, Ba, Ca, Cd, Cu, Fe, Hg, K, Mg, Mn, Na, Sr and Zn in caps and stipes of King Bolete mushroom and in the surface layer of soil (0-10 cm) from the Płocka Dale area of Poland. Hg, Cu, Cd, Zn, Mg and K exhibited bioconcentration factors (BCF) > 1. Specifically, Hg, Cu and Cd (mean BCFs for caps were 110, 19 and 16, respectively) were efficiently bioconcentrated by King Bolete, while other elements were bioexcluded (BCF < 1). Cadmium was present in the caps at mean levels of 5.5 ± 2.4 mg kg(-1) dry weight (dw) and mercury at levels of 4.9 ± 1.4 mg kg(-1) dw, both occurring at elevated concentrations in those King Bolete mushrooms surveyed.

Assessment of risk factors for death in electrical injury.

PubMed

Dokov, William

2009-02-01

Fatal high-voltage injuries present a problem which has not yet been studied sufficiently in the context of interaction between the human body and electricity, as a technical, anthropogenic and natural phenomenon. The forensic medicine records of 291 cases of death caused by high-voltage current for a 41-year-long period (1965-2006) were examined in retrospect. The descriptive statistical analyses were made using the SPSS 11.0 software. Death was found to result most commonly from contact between the deceased and elements of the power transmission and distribution grid: (41.24%), and from the action of lightning: (32.3%), the difference in their relative share being insignificant. Much more rarely, death was due to contact with construction and repair electrical devices: (7.56%), or with elements of the power transport railway infrastructure: (6.87%). Death resulting from contact with agricultural electrical devices was only occasional: (0.68%). The victims' average age was 36.19 years. Our analysis indicates that the relative share (43.98%) of the victims is the highest in the age period between 25 and 44. The ratio between women and men is 1:21.38.

Inductively coupled plasma-mass spectrometric method for the determination of dissolved trace elements in natural water

USGS Publications Warehouse

Garbarino, J.R.; Taylor, Howard E.

1996-01-01

An inductively coupled plasma-mass spectrometry method was developed for the determination of dissolved Al, As, B, Ba, Be, Cd, Co, Cr, Cu, Li, Mn, Mo, Ni, Pb, Sr, Tl, U, V, and Zn in natural waters. Detection limits are generally in the 50-100 picogram per milliliter (pg/mL) range, with the exception of As which is in the 1 microgram per liter (ug/L) range. Interferences associated with spectral overlap from concomitant isotopes or molecular ions and sample matrix composition have been identified. Procedures for interference correction and reduction related to isotope selection, instrumental operating conditions, and mathematical data processing techniques are described. Internal standards are used to minimize instrumental drift. The average analytical precision attainable for 5 times the detection limit is about 16 percent. The accuracy of the method was tested using a series of U.S. Geological Survey Standard Reference Water Standards (SWRS), National Research Council Canada Riverine Water Standard, and National Institute of Standards and Technology (NIST) Trace Elements in Water Standards. Average accuracies range from 90 to 110 percent of the published mean values.

New Fission Fragment Distributions and r-Process Origin of the Rare-Earth Elements

NASA Astrophysics Data System (ADS)

Goriely, S.; Sida, J.-L.; Lemaître, J.-F.; Panebianco, S.; Dubray, N.; Hilaire, S.; Bauswein, A.; Janka, H.-T.

2013-12-01

Neutron star (NS) merger ejecta offer a viable site for the production of heavy r-process elements with nuclear mass numbers A≳140. The crucial role of fission recycling is responsible for the robustness of this site against many astrophysical uncertainties, but calculations sensitively depend on nuclear physics. In particular, the fission fragment yields determine the creation of 110≲A≲170 nuclei. Here, we apply a new scission-point model, called SPY, to derive the fission fragment distribution (FFD) of all relevant neutron-rich, fissioning nuclei. The model predicts a doubly asymmetric FFD in the abundant A≃278 mass region that is responsible for the final recycling of the fissioning material. Using ejecta conditions based on relativistic NS merger calculations, we show that this specific FFD leads to a production of the A≃165 rare-earth peak that is nicely compatible with the abundance patterns in the Sun and metal-poor stars. This new finding further strengthens the case of NS mergers as possible dominant origin of r nuclei with A≳140.

Effects of trace elements on the crystal field parameters of Nd ions at the surface of Nd{sub 2}Fe{sub 14}B grains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toga, Yuta; Suzuki, Tsuneaki; Sakuma, Akimasa, E-mail: sakuma@solid.apph.tohoku.ac.jp

2015-06-14

Using first-principles calculations, we investigate the positional dependence of trace elements such as O and Cu on the crystal field parameter A{sub 2}{sup 0}, proportional to the magnetic anisotropy constant K{sub u} of Nd ions placed at the surface of Nd{sub 2}Fe{sub 14}B grains. The results suggest the possibility that the A{sub 2}{sup 0} parameter of Nd ions at the (001) surface of Nd{sub 2}Fe{sub 14}B grains exhibits a negative value when the O or Cu atom is located near the surface, closer than its equilibrium position. At the (110) surface, however, O atoms located at the equilibrium position providemore » a negative A{sub 2}{sup 0}, while for Cu additions A{sub 2}{sup 0} remains positive regardless of Cu's position. Thus, Cu atoms are expected to maintain a positive local K{sub u} of surface Nd ions more frequently than O atoms when they approach the grain surfaces in the Nd-Fe-B grains.« less

ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor

PubMed Central

Simond, Alexandra M.; Rao, Trisha; Zuo, Dongmei; Zhao, Jean J.; Muller, William J.

2017-01-01

Breast cancer is the most common cancer among women and 30% will be diagnosed with an ErbB2-positive cancer. Forty percent of ErbB2-positive breast tumors have an activating mutation in p110α, a catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical and experimental data show that breast tumors treated with a p110α-specific inhibitor often circumvent inhibition and resume growth. To understand this mechanism of resistance, we crossed a p110α conditional (p110αflx/flx) mouse model with mice that overexpresses the ErbB2/Neu-IRES-Cre transgene (NIC) specifically in the mammary epithelium. Although mammary-specific deletion of p110α dramatically delays tumor onset, tumors eventually arise and are dependent on p110β. Through biochemical analyses we find that a proportion of p110α-deficient tumors (23%) display downregulation of the Pten tumor suppressor. We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110α to p110β in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110α inhibition. PMID:28783168

Role of Tat-interacting protein of 110 kDa and microRNAs in the regulation of hematopoiesis.

PubMed

Liu, Ying; He, Johnny J

2016-07-01

Hematopoiesis is regulated by cellular factors including transcription factors, microRNAs, and epigenetic modifiers. Understanding how these factors regulate hematopoiesis is pivotal for manipulating them to achieve their desired potential. In this review, we will focus on HIV-1 Tat-interacting protein of 110 kDa (Tip110) and its regulation of hematopoiesis. There are several pathways in hematopoiesis that involve Tip110 regulation. Tip110 is expressed in human cord blood CD34 cells; its expression decreases when CD34 cells begin to differentiate. Tip110 is also expressed in mouse marrow hematopoietic stem cells (HSC) and hematopoietic progenitor cells (HPC). Tip110 expression increases the number, survival, and cell cycling of HPC. Tip110-mediated regulation of hematopoiesis has been linked to its reciprocal control of proto-oncogene expression. Small noncoding microRNAs (miRs) have been shown to play important roles in regulation of hematopoiesis. miR-124 specifically targets 3'-untranslated region of Tip110 and subsequently regulates Tip110 expression in HSC. Our recent findings for manipulating expression levels of Tip110 in HSC and HPC could be useful for expanding HSC and HPC and for improving engraftment of cord blood HSC/HPC.

The atomic geometries of GaP(110) and ZnS(110) revisited - A structural ambiguity and its resolution

NASA Technical Reports Server (NTRS)

Duke, C. B.; Paton, A.; Kahn, A.

1984-01-01

The atomic geometries of GaP(110) and ZnS(110) are reexamined using the R-factor minimization procedure, developed for GaAs(110) and previously applied to GaSb(110), ZnTe(110), InAs(110), and AlP(110), to analyze experimental elastic low-energy electron diffraction intensities. Unlike most of the earlier cases, both GaP(110) and ZnS(110) exhibit two distinct minimum-Rx structures which cannot be distinguished by analysis of the shapes of the intensity profiles alone. One region of best-fit structures exhibits top-layer displacements normal to the surface characterized by a small bond-length-conserving, top-layer rotation (omega aproximately 2-3 deg), a small relaxation of the top layer away from the surface, and a 10 percent expansion of the top-layer bond length. The other region of best-fit structures is the conventional one: nearly bond-length-conserving rotations of omega = 26-28 deg in the top layer and a small (approximately 0.1 A) contraction of the uppermost layer spacing. This ambiguity may be removed, however, by consideration of the integrated beam intensities. The conventional region of structural parameters provides a decisively better description of the relative magnitudes of the integrated beam intensities and hence is the preferred structure.

Search for naturally occurring superheavy elements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoughton, R.W.; Halperin, J.; Drury, J.S.

1973-11-12

Several ores, minerals, concentrates and special samples were examined for evidence of superheavy elements using a neutron multiplicity counter. This counter contains 20 /sup 3/He detectors in a paraffin matrix, and enables evaluation of the emitted neutron multiplicity spectrum of large samples with littie or no chemical processing. Such measurements provide an effective tool in the search for superheavy elements, since their decay or the decay of daughter nuclides is expected to proceed by spontaneous fission. In a search for Element 114(ekalead) a massive galena sample and a sample of galena-barite were examined, together with some chalcophilic samples, iron andmore » zinc sulphides, cerussite (PbCO/ sub 3/), and flux dust samples in Cottrell precipitators from the roasting of pentlandite (iron nickel sulphide). Element 114 would be expected to be more volatile than Hg, and intermediate between Pb and Au in nobility, and for this reason a technique was applied which was successfully developed to locate Hg ore bodies. This technique is described. In another attempt to detect possible volatile superheavy elements, such as 118 (ekaradon) or 112 (ekamercury) a sample of silica gel was examined, previously used in a plant for the production of noble gases; a gas mixture of crude Xe from the same plant was also investigated. With regard to Element 110 (ekaplatinum) several ultrabasic rocks were examined. For Element 119 (ekafracium) several potash ores were examined, as well as bittern from the Great Salt Lake, Utah. A sample of native Bi, as well as reagent Bi, were examined for Element 115 (ekabismuth). Several special samples included iron-rich meteorites, samples of biotite in which dwarf haloes had been found, some monazite samples associated with giant haloes, and some haematite and magnetite samples; also manganese nodules, sharks' teeth, and carbonaceous chondrite meteorite samples. The latter were particularly interesting since there is a Xe component in some carbonaceous chondrites that shows a higher /sup 136/Xe/sup 134/Xe ratio than Xe from any known fission source, possibly due to fission of one or more relatively volatile superheavy elements. All the results are summarized in tabular form. None of the samples examined showed evidence of spontaneous fission rates in excess of the detection limit. (UK)« less

The ZnSe(110) puzzle - Comparison with GaAs(110)

NASA Technical Reports Server (NTRS)

Duke, C. B.; Paton, A.; Kahn, A.; Tu, D.-W.

1984-01-01

The surface structure of monocrystalline ZnSe(110) and of 4-5-nm-thick ZnSe(110) layers epitaxially grown on GaAs(110) is investigated by means of elastic LEED and AES; the results are analyzed using the computer programs and R-factor methods of Duke et al. (1981 and 1983), presented in graphs and tables, and compared to those for GaAs(110). Significant differences are attributed to bond-length-conserving outward rotation of Se and inward rotation of Zn in the top layer, with an angle of 4 deg between the actual plane of the cation-anion chain and the truncated bulk surface. The R intensities measured for ZnSe(110) and GaAs(110) are given as Rx = 0.22 and RI = 0.21 and Rx = 0.24 and RI = 0.16, respectively.

Optimum rolling ratio for obtaining {001}<110> recrystallization texture in Ti-Nb-Al biomedical shape memory alloy.

PubMed

Inamura, T; Shimizu, R; Kim, H Y; Miyazaki, S; Hosoda, H

2016-04-01

The rolling rate (r) dependence of textures was investigated in the Ti-26Nb-3Al (mol%) alloy to reveal the conditions required to form the {001}<110> recrystallization texture, which is a desirable orientation for the β-titanium shape memory alloy. {001}<110> was the dominant cold-rolling texture when r=90% and it was transferred to the recrystallization texture without forming {112}<110>, which is detrimental for the isotropic mechanical properties of the rolled sheet. A further increase in r resulted in the formation of {112}<110> in both rolling and recrystallization textures. Therefore, r should be controlled to form only the {001}<110> rolling texture, because the {112}<110> texture can overwhelm the {001}<110> texture during recrystallization. Copyright © 2016 Elsevier B.V. All rights reserved.

Cyclin-dependent kinase 11p110 (CDK11p110) is crucial for human breast cancer cell proliferation and growth

PubMed Central

Zhou, Yubing; Han, Chao; Li, Duolu; Yu, Zujiang; Li, Fengmei; Li, Feng; An, Qi; Bai, Huili; Zhang, Xiaojian; Duan, Zhenfeng; Kan, Quancheng

2015-01-01

Cyclin-dependent kinases (CDKs) play important roles in the development of many types of cancers by binding with their paired cyclins. However, the function of CDK11 larger protein isomer, CDK11p110, in the tumorigenesis of human breast cancer remains unclear. In the present study, we explored the effects and molecular mechanisms of CDK11p110 in the proliferation and growth of breast cancer cells by determining the expression of CDK11p110 in breast tumor tissues and examining the phenotypic changes of breast cancer cells after CDK11p110 knockdown. We found that CDK11p110 was highly expressed in breast tumor tissues and cell lines. Tissue microarray analysis showed that elevated CDK11p110 expression in breast cancer tissues significantly correlated with poor differentiation, and was also associated with advanced TNM stage and poor clinical prognosis for breast cancer patients. In vitro knockdown of CDK11p110 by siRNA significantly inhibited cell growth and migration, and dramatically induced apoptosis in breast cancer cells. Flow cytometry demonstrated that cells were markedly arrested in G1 phase of the cell cycle after CDK11p110 downregulation. These findings suggest that CDK11p110 is critical for the proliferation and growth of breast cancer cells, which highlights CDK11p110 may be a promising therapeutic target for the treatment of breast cancer. PMID:25990212

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

PubMed Central

Whitehead, Maria A.; Bombardieri, Michele; Pitzalis, Costantino; Vanhaesebroeck, Bart

2012-01-01

PI3Ks (phosphoinositide 3-kinases) are signalling molecules and drug targets with important biological functions, yet the regulation of PI3K gene expression is poorly understood. Key PI3Ks are the class IA PI3Ks that consist of a catalytic subunit (p110α, p110β and p110δ) in complex with a p85 regulatory subunit. Whereas p110α and p110β are ubiquitously expressed, high levels of p110δ are mainly found in white blood cells, with most non-leucocytes expressing low levels of p110δ. In the present paper we report that TNFα (tumour necrosis factor α) stimulation induces p110δ expression in human ECs (endothelial cells) and synovial fibroblasts, but not in leucocytes, through transcription start sites located in a novel promoter region in the p110δ gene (PIK3CD). This promoter is used in all cell types, including solid tumour cell lines that express p110δ, and is activated by TNFα in ECs and synovial fibroblasts. We further present a detailed biochemical and bioinformatic characterization of p110δ gene regulation, demonstrating that PIK3CD has distinct promoters, some of which can be dynamically activated by pro-inflammatory mediators. This is the first molecular identification of a PI3K promoter under the control of acute extracellular stimulation. PMID:22375552

Hotspots for selected metal elements and microbes accumulation and the corresponding water quality deterioration potential in an unchlorinated drinking water distribution system.

PubMed

Liu, Gang; Tao, Yu; Zhang, Ya; Lut, Maarten; Knibbe, Willem-Jan; van der Wielen, Paul; Liu, Wentso; Medema, Gertjan; van der Meer, Walter

2017-11-01

Biofilm formation, loose deposit accumulation and water quality deterioration in drinking water distribution systems have been widely reported. However, the accumulation and distribution of harbored elements and microbes in the different niches (loose deposits, PVC-U biofilm, and HDPE biofilm) and their corresponding potential contribution to water quality deterioration remain unknown. This precludes an in-depth understanding of water quality deterioration and the development of proactive management strategies. The present study quantitatively evaluated the distribution of elements, ATP, Aeromonas spp., and bacterial communities in distribution pipes (PVC-U, D = 110 mm, loose deposit and biofilm niches) and household connection pipes (HDPE, D = 32 mm, HDPE biofilm niches) at ten locations in an unchlorinated distribution system. The results show that loose deposits in PVC-U pipes, acting as sinks, constitute a hotspot (highest total amount per meter pipe) for elements, ATP, and target bacteria groups (e.g., Aeromonas spp., Mycobacterium spp., and Legionella spp.). When drinking water distribution system niches with harbored elements and microbes become sources in the event of disturbances, the highest quality deterioration potential (QDP) is that of HDPE biofilm; this can be attributed to its high surface-to-volume ratio. 16s rRNA analysis demonstrates that, at the genus level, the bacterial communities in the water, loose deposits, PVC-U biofilm, and HDPE biofilm were dominated, respectively, by Polaromonas spp. (2-23%), Nitrosipra spp. (1-47%), Flavobacterium spp. (1-36%), and Flavobacterium spp. (5-67%). The combined results of elemental composition and bacterial community analyses indicate that different dominant bio-chemical processes might occur within the different niches-for example, iron-arsenic oxidizing in loose deposits, bio-calumniation in PVC-U biofilm, and methane oxidizing in HDPE biofilm. The release of 20% loose deposits, 20% PVC-U biofilm and 10% HDPE biofilm will cause significant changes of water bacterial community. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Final Long-Term Management and Storage of Elemental Mercury Environmental Impact Statement Volume1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2011-01-01

Pursuant to the Mercury Export Ban Act of 2008 (P.L. 110-414), DOE was directed to designate a facility or facilities for the long-term management and storage of elemental mercury generated within the United States. Therefore, DOE has analyzed the storage of up to 10,000 metric tons (11,000 tons) of elemental mercury in a facility(ies) constructed and operated in accordance with the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act (74 FR 31723).DOE prepared this Final Mercury Storage EIS in accordance with the National Environmental Policy Act of 1969 (NEPA), as amended (42 U.S.C. 4321 etmore » seq.), the Council on Environmental Quality (CEQ) implementing regulations (40 CFR 1500–1508), and DOE’s NEPA implementing procedures (10 CFR 1021) to evaluate reasonable alternatives for a facility(ies) for the long-term management and storage of elemental mercury. This Final Mercury Storage EIS analyzes the potential environmental, human health, and socioeconomic impacts of elemental mercury storage at seven candidate locations:Grand Junction Disposal Site near Grand Junction, Colorado; Hanford Site near Richland, Washington; Hawthorne Army Depot near Hawthorne, Nevada; Idaho National Laboratory near Idaho Falls, Idaho;Kansas City Plant in Kansas City, Missouri; Savannah River Site near Aiken, South Carolina; and Waste Control Specialists, LLC, site near Andrews, Texas. As required by CEQ NEPA regulations, the No Action Alternative was also analyzed as a basis for comparison. DOE intends to decide (1) where to locate the elemental mercury storage facility(ies) and (2) whether to use existing buildings, new buildings, or a combination of existing and new buildings. DOE’s Preferred Alternative for the long-term management and storage of mercury is the Waste Control Specialists, LLC, site near Andrews, Texas.« less

Complete genetic analysis of plasmids carrying mcr-1 and other resistance genes in an Escherichia coli isolate of animal origin.

PubMed

Li, Ruichao; Xie, Miaomiao; Lv, Jingzhang; Wai-Chi Chan, Edward; Chen, Sheng

2017-03-01

To investigate the genetic features of three plasmids recovered from an MCR-1 and ESBL-producing Escherichia coli strain, HYEC7, and characterize the transmission mechanism of mcr-1 . The genetic profiles of three plasmids were determined by PCR, S1-PFGE, Southern hybridization and WGS analysis. The ability of the mcr-1 -bearing plasmid to undergo conjugation was also assessed. The mcr-1 -bearing transposon Tn 6330 was characterized by PCR and DNA sequencing. Complete sequences of three plasmids were obtained. A non-conjugative phage P7-like plasmid, pHYEC7- mcr1 , was found to harbour the mcr-1 -bearing transposon Tn 6330 , which could be excised from the plasmid by generating a circular intermediate harbouring mcr-1 and the IS Apl1 element. The insertion of the circular intermediate into another plasmid, pHYEC7-IncHI2, could form pHNSHP45-2, the original IncHI2-type mcr-1 -carrying plasmid that was reported. The third plasmid, pHYEC7-110, harboured two replicons, IncX1 and IncFIB, and comprised multiple antimicrobial resistance mobile elements, some of which were shared by pHYEC7-IncHI2. The Tn 6330 element located in the phage-like plasmid pHYEC7- mcr1 could be excised from the plasmid and formed a circular intermediate that could be integrated into plasmids containing the IS Apl1 element. This phenomenon indicated that Tn 6330 is a key element responsible for widespread dissemination of mcr-1 among various types of plasmids and bacterial chromosomes. The dissemination rate of such an element may be further enhanced upon translocation into phage-like vectors, which may also be transmitted via transduction events. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Characterization of size, morphology and elemental composition of nano-, submicron, and micron particles of street dust separated using field-flow fractionation in a rotating coiled column.

PubMed

Fedotov, Petr S; Ermolin, Mikhail S; Karandashev, Vasily K; Ladonin, Dmitry V

2014-12-01

For the first time, nano- and submicron particles of street dust have been separated, weighted, and analyzed. A novel technique, sedimentation field-flow fractionation in a rotating coiled column, was applied to the fractionation of dust samples with water being used as a carrier fluid. The size and morphology of particles in the separated fractions were characterized by electronic microscopy before digestion and the determination of the concentration of elements by ICP-AES and ICP-MS. The elements that may be of anthropogenic origin (Zn, Cr, Ni, Cu, Cd, Sn, Pb) were found to concentrate mainly in <0.3 and 0.3-1 μm fractions. It has been shown that the concentrations of Cr, Ni, Zn in the finest fraction (<0.3 μm) of street dust can be one order of magnitude higher than the concentrations of elements in bulk sample and coarse fractions. For example, the concentrations of Ni in <0.3, 0.3-1, 1-10, and 10-100 μm fractions were 297 ± 46, 130 ± 21, 36 ± 10, and 21 ± 4 mg/kg, correspondingly. Though the finest particles present only about 0.1 mass% of the sample they are of special concern due to their increased mobility and ability to penetrate into the deepest alveolar area of the lungs. For rare earth elements (La, Ce, Pr, Nd, Sm) that are evidently of natural source and may be found in soil minerals, in contrary, higher concentrations were observed in large particles (10-100 μm). Sc was an exception that needs further studies. The proposed approach to the fractionation and analysis of nano-, submicron, and micron particles can be a powerful tool for risk assessment related to toxic elements in dust, ash, and other particulate environmental samples. Copyright © 2014 Elsevier B.V. All rights reserved.

Final Long-Term Management and Storage of Elemental Mercury Environmental Impact Statement Volume 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Pursuant to the Mercury Export Ban Act of 2008 (P.L. 110-414), DOE was directed to designate a facility or facilities for the long-term management and storage of elemental mercury generated within the United States. Therefore, DOE has analyzed the storage of up to 10,000 metric tons (11,000 tons) of elemental mercury in a facility(ies) constructed and operated in accordance with the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act (74 FR 31723). DOE prepared this Final Mercury Storage EIS in accordance with the National Environmental Policy Act of 1969 (NEPA), as amended (42 U.S.C. 4321more » et seq.), the Council on Environmental Quality (CEQ) implementing regulations (40 CFR 1500–1508), and DOE’s NEPA implementing procedures (10 CFR 1021) to evaluate reasonable alternatives for a facility(ies) for the long-term management and storage of elemental mercury. This Final Mercury Storage EIS analyzes the potential environmental, human health, and socioeconomic impacts of elemental mercury storage at seven candidate locations: Grand Junction Disposal Site near Grand Junction, Colorado; Hanford Site near Richland, Washington; Hawthorne Army Depot near Hawthorne, Nevada; Idaho National Laboratory near Idaho Falls, Idaho; Kansas City Plant in Kansas City, Missouri; Savannah River Site near Aiken, South Carolina; and Waste Control Specialists, LLC, site near Andrews, Texas. As required by CEQ NEPA regulations, the No Action Alternative was also analyzed as a basis for comparison. DOE intends to decide (1) where to locate the elemental mercury storage facility(ies) and (2) whether to use existing buildings, new buildings, or a combination of existing and new buildings. DOE’s Preferred Alternative for the long-term management and storage of mercury is the Waste Control Specialists, LLC, site near Andrews, Texas.« less

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

PubMed Central

Guillermet-Guibert, Julie; Smith, Lee B.; Halet, Guillaume; Whitehead, Maria A.; Pearce, Wayne; Rebourcet, Diane; León, Kelly; Crépieux, Pascale; Nock, Gemma; Strömstedt, Maria; Enerback, Malin; Chelala, Claude; Graupera, Mariona; Carroll, John; Cosulich, Sabina; Saunders, Philippa T. K.; Huhtaniemi, Ilpo; Vanhaesebroeck, Bart

2015-01-01

The organismal roles of the ubiquitously expressed class I PI3K isoform p110β remain largely unknown. Using a new kinase-dead knockin mouse model that mimics constitutive pharmacological inactivation of p110β, we document that full inactivation of p110β leads to embryonic lethality in a substantial fraction of mice. Interestingly, the homozygous p110β kinase-dead mice that survive into adulthood (maximum ~26% on a mixed genetic background) have no apparent phenotypes, other than subfertility in females and complete infertility in males. Systemic inhibition of p110β results in a highly specific blockade in the maturation of spermatogonia to spermatocytes. p110β was previously suggested to signal downstream of the c-kit tyrosine kinase receptor in germ cells to regulate their proliferation and survival. We now report that p110β also plays a germ cell-extrinsic role in the Sertoli cells (SCs) that support the developing sperm, with p110β inactivation dampening expression of the SC-specific Androgen Receptor (AR) target gene Rhox5, a homeobox gene critical for spermatogenesis. All extragonadal androgen-dependent functions remain unaffected by global p110β inactivation. In line with a crucial role for p110β in SCs, selective inactivation of p110β in these cells results in male infertility. Our study is the first documentation of the involvement of a signalling enzyme, PI3K, in the regulation of AR activity during spermatogenesis. This developmental pathway may become active in prostate cancer where p110β and AR have previously been reported to functionally interact. PMID:26132308

40 CFR 405.110 - Applicability; description of the condensed whey subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... condensed whey subcategory. 405.110 Section 405.110 Protection of Environment ENVIRONMENTAL PROTECTION... Condensed Whey Subcategory § 405.110 Applicability; description of the condensed whey subcategory. The... whey and condensed acid whey. ...

Laser-ablation ICP-MS as a tool for whole rock trace element analyses on fused powders

NASA Astrophysics Data System (ADS)

Girard, G.; Rooney, T. O.

2013-12-01

Here we present an accurate and precise technique for routine trace element analysis of geologic materials by laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). We focus on rock powders previously prepared for X-ray fluorescence by fusion in a Li2B4O7 flux, and subsequently quenched in a Pt mold to form a glass disk. Our method allows for the analysis up to 30 trace elements by LA-ICP-MS using a Photon-Machines Analyte G2 193 nm excimer laser coupled to a Thermo-Fisher Scientific ICAP Q quadrupole ICP-MS. Analyses are run as scans on the surface of the disks. Laser ablation conditions for which trace element fractionation effects are minimal have been empirically determined to be ~ 4 J m-2 fluence, at 10 Hz , and 10 μm s-1 scan speed, using a 110 μm laser beam size. Ablated material is carried into the ICP-MS by a He carrier at a rate of 0.75 L min-1. Following pre-ablation to remove surface particles, samples are ablated for 200 s, of which 140 s are used for data acquisition. At the end of each scan, a gas blank is collected for 30 s. Dwell times for each element vary between 15 and 60 μs, depending on abundance and instrument sensitivity, allowing 120 readings of each element during the data acquisition time window. To correct for variations in the total volume of material extracted by the laser, three internal standards are used, Ca, Fe and Zr. These elements are routinely analyzed by X-ray fluorescence by the Geoanalytical laboratory at Michigan State University with precision and accuracy of <5%. The availability of several internal standards allows for better correction of possible persisting laser ablation fractionation effects; for a particular trace element, we correct using the internal standard that best reproduces its ablation behavior. Our calibration is based on a combination of fused powders of US Geological Survey and Geological Survey of Japan rock standards, NIST SRM 612 glass, and US Geological Survey natural and synthetic basalt glasses. Instrumental drift is monitored during each run using two fused standards analyzed multiple times as unknowns. We routinely achieve an external precision of <5% on multiple replicates of standards run as unknowns, which are also within <5% of certified values. Elements analyzed include most first row transition metals, large ion lithophile elements, high field strength elements, lanthanide and actinide rare earth elements.

Assimilation of trace elements ingested by the mussel Mytilus edulis: effects of algal food abundance

USGS Publications Warehouse

Wang, W.-X.; Fisher, N.S.; Luoma, S. N.

1995-01-01

Pulse-chase feeding and multi-labeled radiotracer techniques were employed to measure the assimilation of 6 trace elements (110mAg, 241Am, 109Cd, 57Co, 75Se and 65Zn) from ingested diatoms in the mussel Mytilus edulis feeding at different rates (0.1, 0.49 and 1.5 mg dry wt h-1). Uniformly radiolabeled diatoms Thalassiosira pseudonana were fed to mussels for 0.5 h, and the behavior of the radiotracers in individual mussels was followed for 96 h in a depuration seawater system. Assimilation efficiency (AE) of each element declined with increasing ingestion rate and increased with gut passage time. The importance of extracellular digestion relative to intracellular digestion increased with ingestion activity, which, when coupled with a decline in AE, suggested that extracellular digestion is less efficient in metal absorption. Zn assimilation was most affected by ingestion rate, suggesting that AE may play a role in the physiological regulation of this metal in M. edulis. In an experiment to simulate the effects of an acidic gut, lowered pH (5.5) enhanced the release of elements from intact diatom cells, especially at low particle concentration. These results indicate that both feeding components of the mussel (i.e. gut passage time, digestive partitioning) and metal chemistry (i.e. metal release at lowered pH within the bivalve gut) are responsible for the difference in the assimilation of trace metals at different food quantities observed in mussels.

Spectral and Wavefront Error Performance of WFIRST-AFTA Bandpass Filter Coating Prototypes

NASA Technical Reports Server (NTRS)

Quijada, Manuel A.; Seide, Laurie; Pasquale, Bert A.; McMann, Joseph C.; Hagopian, John G.; Dominguez, Margaret Z.; Gong, Quian; Marx, Catherine T.

2016-01-01

The Cycle 5 design baseline for the Wide-Field Infrared Survey Telescope Astrophysics Focused Telescope Assets (WFIRST/AFTA) instrument includes a single wide-field channel (WFC) instrument for both imaging and slit-less spectroscopy. The only routinely moving part during scientific observations for this wide-field channel is the element wheel (EW) assembly. This filter-wheel assembly will have 8 positions that will be populated with 6 bandpass filters, a blank position, and a Grism that will consist of a three-element assembly to disperse the full field with an undeviated central wavelength for galaxy redshift surveys. All filter elements in the EW assembly will be made out of fused silica substrates (110 mm diameter) that will have the appropriate bandpass coatings according to the filter designations (Z087, Y106, J129, H158, F184, W149 and Grism). This paper presents and discusses the performance (including spectral transmission and reflected/transmitted wavefront error measurements) of a subset of bandpass filter coating prototypes that are based on the WFC instrument filter compliment. The bandpass coating prototypes that are tested in this effort correspond to the Z087, W149, and Grism filter elements. These filter coatings have been procured from three different vendors to assess the most challenging aspects in terms of the in-band throughput, out of band rejection (including the cut-on and cutoff slopes), and the impact the wavefront error distortions of these filter coatings will have on the imaging performance of the wide-field channel in the WFIRST/AFTA observatory.

Friends-enemies: endogenous retroviruses are major transcriptional regulators of human DNA

NASA Astrophysics Data System (ADS)

Buzdin, Anton A.; Prassolov, Vladimir; Garazha, Andrew V.

2017-06-01

Endogenous retroviruses are mobile genetic elements hardly distinguishable from infectious, or “exogenous”, retroviruses at the time of insertion in the host DNA. Human endogenous retroviruses (HERVs) are not rare. They gave rise to multiple families of closely related mobile elements that occupy 8% of the human genome. Together, they shape genomic regulatory landscape by providing at least 320,000 human transcription factor binding sites (TFBS) located on 110,000 individual HERV elements. The HERVs host as many as 155,000 mapped DNaseI hypersensitivity sites, which denote loci active in the regulation of gene expression or chromatin structure. The contemporary view of the HERVs evolutionary dynamics suggests that at the early stages after insertion, the HERV is treated by the host cells as a foreign genetic element, and is likely to be suppressed by the targeted methylation and mutations. However, at the later stages, when significant number of mutations has been already accumulated and when the retroviral genes are broken, the regulatory potential of a HERV may be released and recruited to modify the genomic balance of transcription factor binding sites. This process goes together with further accumulation and selection of mutations, which reshape the regulatory landscape of the human DNA. However, developmental reprogramming, stress or pathological conditions like cancer, inflammation and infectious diseases, can remove the blocks limiting expression and HERV-mediated host gene regulation. This, in turn, can dramatically alter the gene expression equilibrium and shift it to a newer state, thus further amplifying instability and exacerbating the stressful situation.

Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.

PubMed

Kumasaka, Mayuko Y; Yamanoshita, Osamu; Shimizu, Shingo; Ohnuma, Shoko; Furuta, Akio; Yajima, Ichiro; Nizam, Saika; Khalequzzaman, Md; Shekhar, Hossain U; Nakajima, Tamie; Kato, Masashi

2013-03-01

Various carcinomas including skin cancer are explosively increasing in arsenicosis patients who drink arsenic-polluted well water, especially in Bangladesh. Although well drinking water in the cancer-prone areas contains various elements, very little is known about the effects of elements except arsenic on carcinogenicity. In order to clarify the carcinogenic effects of coexposure to arsenic and iron, anchorage-independent growth and invasion in human untransformed HaCaT and transformed A431 keratinocytes were examined. Since the mean ratio of arsenic and iron in well water was 1:10 in cancer-prone areas of Bangladesh, effects of 1 μM arsenic and 10 μM iron were investigated. Iron synergistically promoted arsenic-mediated anchorage-independent growth in untransformed and transformed keratinocytes. Iron additionally increased invasion in both types of keratinocytes. Activities of c-SRC and ERK that regulate anchorage-independent growth and invasion were synergistically enhanced in both types of keratinocytes. Our results suggest that iron promotes arsenic-mediated transformation of untransformed keratinocytes and progression of transformed keratinocytes. We then developed a low-cost and high-performance adsorbent composed of a hydrotalcite-like compound for arsenic and iron. The adsorbent rapidly reduced concentrations of both elements from well drinking water in cancer-prone areas of Bangladesh to levels less than those in WHO health-based guidelines for drinking water. Thus, we not only demonstrated for the first time increased carcinogenicity by coexposure to arsenic and iron but also proposed a novel remediation system for well drinking water.

ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

PubMed

Aragoneses-Fenoll, L; Montes-Casado, M; Ojeda, G; Acosta, Y Y; Herranz, J; Martínez, S; Blanco-Aparicio, C; Criado, G; Pastor, J; Dianzani, U; Portolés, P; Rojo, J M

2016-04-15

Class IA phosphoinositide 3-kinases (PI3Ks) are essential to function of normal and tumor cells, and to modulate immune responses. T lymphocytes express high levels of p110α and p110δ class IA PI3K. Whereas the functioning of PI3K p110δ in immune and autoimmune reactions is well established, the role of p110α is less well understood. Here, a novel dual p110α/δ inhibitor (ETP-46321) and highly specific p110α (A66) or p110δ (IC87114) inhibitors have been compared concerning T cell activation in vitro, as well as the effect on responses to protein antigen and collagen-induced arthritis in vivo. In vitro activation of naive CD4(+) T lymphocytes by anti-CD3 and anti-CD28 was inhibited more effectively by the p110δ inhibitor than by the p110α inhibitor as measured by cytokine secretion (IL-2, IL-10, and IFN-γ), T-bet expression and NFAT activation. In activated CD4(+) T cells re-stimulated through CD3 and ICOS, IC87114 inhibited Akt and Erk activation, and the secretion of IL-2, IL-4, IL-17A, and IFN-γ better than A66. The p110α/δ inhibitor ETP-46321, or p110α plus p110δ inhibitors also inhibited IL-21 secretion by differentiated CD4(+) T follicular (Tfh) or IL-17-producing (Th17) helper cells. In vivo, therapeutic administration of ETP-46321 significantly inhibited responses to protein antigen as well as collagen-induced arthritis, as measured by antigen-specific antibody responses, secretion of IL-10, IL-17A or IFN-γ, or clinical symptoms. Hence, p110α as well as p110δ Class IA PI3Ks are important to immune regulation; inhibition of both subunits may be an effective therapeutic approach in inflammatory autoimmune diseases like rheumatoid arthritis. Copyright © 2016 Elsevier Inc. All rights reserved.

40 CFR 141.110 - General requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false General requirements. 141.110 Section 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements...

40 CFR 141.110 - General requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false General requirements. 141.110 Section 141.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Treatment Techniques § 141.110 General requirements...

48 CFR 49.110 - Settlement negotiation memorandum.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Settlement negotiation memorandum. 49.110 Section 49.110 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.110 Settlement negotiation memorandum...

T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response

PubMed Central

Aragoneses-Fenoll, Laura; Ojeda, Gloria; Montes-Casado, María; Acosta-Ampudia, Yeny; Dianzani, Umberto; Portolés, Pilar; Rojo, José M.

2018-01-01

Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The role of p110δ PI3K in normal or pathological immune responses is well established, yet the importance of p110α subunits in T cell-dependent immune responses is not clear. To address this problem, mice with p110α conditionally deleted in CD4+ and CD8+ T lymphocytes (p110α−/−ΔT) were used. p110α−/−ΔT mice show normal development of T cell subsets, but slightly reduced numbers of CD4+ T cells in the spleen. “In vitro,” TCR/CD3 plus CD28 activation of naive CD4+ and CD8+ p110α−/−ΔT T cells showed enhanced effector function, particularly IFN-γ secretion, T-bet induction, and Akt, Erk, or P38 activation. Tfh derived from p110α−/−ΔT cells also have enhanced responses when compared to normal mice, and IL-2 expanded p110α−/−ΔT CD8+ T cells had enhanced levels of LAMP-1 and Granzyme B. By contrast, the expansion of p110α−/−ΔT iTreg cells was diminished. Also, p110α−/−ΔT mice had enhanced anti-keyhole limpet hemocyanin (KLH) IFN-γ, or IL-4 responses and IgG1 and IgG2b anti-KLH antibodies, using CFA or Alum as adjuvant, respectively. When compared to WT mice, p110α−/−ΔT mice inoculated with B16.F10 melanoma showed delayed tumor progression. The percentage of CD8+ T lymphocytes was higher and the percentage of Treg cells lower in the spleen of tumor-bearing p110α−/−ΔT mice. Also, IFN-γ production in tumor antigen-activated spleen cells was enhanced. Thus, PI3K p110α plays a significant role in antigen activation and differentiation of CD4+ and CD8+ T lymphocytes modulating antitumor immunity. PMID:29535720

Modeling the high-frequency complex modulus of silicone rubber using standing Lamb waves and an inverse finite element method.

PubMed

Jonsson, Ulf; Lindahl, Olof; Andersson, Britt

2014-12-01

To gain an understanding of the high-frequency elastic properties of silicone rubber, a finite element model of a cylindrical piezoelectric element, in contact with a silicone rubber disk, was constructed. The frequency-dependent elastic modulus of the silicone rubber was modeled by a fourparameter fractional derivative viscoelastic model in the 100 to 250 kHz frequency range. The calculations were carried out in the range of the first radial resonance frequency of the sensor. At the resonance, the hyperelastic effect of the silicone rubber was modeled by a hyperelastic compensating function. The calculated response was matched to the measured response by using the transitional peaks in the impedance spectrum that originates from the switching of standing Lamb wave modes in the silicone rubber. To validate the results, the impedance responses of three 5-mm-thick silicone rubber disks, with different radial lengths, were measured. The calculated and measured transitional frequencies have been compared in detail. The comparison showed very good agreement, with average relative differences of 0.7%, 0.6%, and 0.7% for the silicone rubber samples with radial lengths of 38.0, 21.4, and 11.0 mm, respectively. The average complex elastic moduli of the samples were (0.97 + 0.009i) GPa at 100 kHz and (0.97 + 0.005i) GPa at 250 kHz.

Control of interior surface materials for speech privacy in high-speed train cabins.

PubMed

Jang, H S; Lim, H; Jeon, J Y

2017-05-01

The effect of interior materials with various absorption coefficients on speech privacy was investigated in a 1:10 scale model of one high-speed train cabin geometry. The speech transmission index (STI) and privacy distance (r P ) were measured in the train cabin to quantify speech privacy. Measurement cases were selected for the ceiling, sidewall, and front and back walls and were classified as high-, medium- and low-absorption coefficient cases. Interior materials with high absorption coefficients yielded a low r P , and the ceiling had the largest impact on both the STI and r P among the interior elements. Combinations of the three cases were measured, and the maximum reduction in r P by the absorptive surfaces was 2.4 m, which exceeds the space between two rows of chairs in the high-speed train. Additionally, the contribution of the interior elements to speech privacy was analyzed using recorded impulse responses and a multiple regression model for r P using the equivalent absorption area. The analysis confirmed that the ceiling was the most important interior element for improving speech privacy. These results can be used to find the relative decrease in r P in the acoustic design of interior materials to improve speech privacy in train cabins. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Characterization of thunderstorm induced Maxwell current densities in the middle atmosphere

NASA Technical Reports Server (NTRS)

Baginski, Michael Edward

1989-01-01

Middle atmospheric transient Maxwell current densities generated by lightning induced charge perturbations are investigated via a simulation of Maxwell's equations. A time domain finite element analysis is employed for the simulations. The atmosphere is modeled as a region contained within a right circular cylinder with a height of 110 km and radius of 80 km. A composite conductivity profile based on measured data is used when charge perturbations are centered about the vertical axis at altitudes of 6 and 10 km. The simulations indicate that the temporal structure of the Maxwell current density is relatively insensitive to altitude variation within the region considered. It is also shown that the electric field and Maxwell current density are not generally aligned.

KSC-03pd0752

NASA Image and Video Library

2003-03-17

KENNEDY SPACE CENTER, FLA. - In the Payload Hazardous Servicing Facility, workers align the Rover Equipment Deck (RED) on one of the Mars Exploration Rovers (MER) with the Warm Electronics Box (WEB). Processing of the rovers, plus cruise stage, lander and heat shield elements, is ongoing. Set to launch in 2003, the MER Mission will consist of two identical rovers designed to cover roughly 110 yards each Martian day. Each rover will carry five scientific instruments that will allow it to search for evidence of liquid water that may have been present in the planet's past. The rovers will be identical to each other, but will land at different regions of Mars. The first rover has a launch window opening May 30, and the second rover a window opening June 25, 2003.

Computational study of alkali-metal-noble gas collisions in the presence of nonresonant lasers - Na + Xe + h/2/pi/omega sub 1 + h/2/pi/omega sub 2 system

NASA Technical Reports Server (NTRS)

Devries, P. L.; Chang, C.; George, T. F.; Laskowski, B.; Stallcop, J. R.

1980-01-01

The collision of Na with Xe in the presence of both the rhodamine-110 dye laser and the Nd-glass laser is investigated within a quantum-mechanical close-coupled formalism, utilizing ab initio potential curves and transition dipole matrix elements. Both one- and two-photon processes are investigated; the Na + Xe system is not asymptotically resonant with the radiation fields, so that these processes can only occur in the molecular collision region. The one-photon processes are found to have measurable cross sections at relatively low intensities; even the two-photon process has a significant section for field intensities as low as 10 MW/sq cm.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wedding, Jason L.; Harris, Hugh H.; Bader, Christie A.

Optical fluorescence microscopy was used in conjunction with X-ray fluorescence microscopy to monitor the stability and intracellular distribution of the luminescent rhenium(I) complex fac-[Re(CO) 3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex, in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence techniques. Furthermore, X-ray fluorescence also showed that the Re-I complex disrupted the homeostasis of some biologically relevant elements,more » such as chlorine, potassium and zinc.« less

Two-Electron Photoejection of He and H{sup {minus}}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyer, K.W.; Greene, C.H.; Esry, B.D.

1997-06-01

In order to overcome difficulties in the description of the two-electron continuum problem, we develop a finite element method to treat two-electron escape processes. Two-electron photoejection cross sections are obtained for helium and H{sup {minus}} at photon energies in the range of 79{endash}460 and 14.4{endash}110eV. The H{sup {minus}} double detachment calculations are apparently the first nonperturbative quantum results in this energy range since the pioneering work of Broad and Reinhardt in 1976. Our branching ratio between single and double detachment of H{sup {minus}} peaks at a value 25{percent}{endash}40{percent} higher than the results from that early study. {copyright} {ital 1997} {italmore » The American Physical Society}« less

Synthesis Characterization and DNA Interaction Studies of a New Zn(II) Complex Containing Different Dinitrogen Aromatic Ligands

PubMed Central

Shahabadi, Nahid; Mohammadi, Somaye

2012-01-01

A mononuclear complex of Zn(II), [Zn(DIP)2 (DMP)] (NO3)2 ·2H2O in which DIP is 4,7-diphenyl-1,10-phenanthroline and DMP is 4,4′-dimethyl-2,2′-bipyridine has been prepared and characterized by 1HNMR spectroscopy, FT-IR, UV-Vis and elemental analysis techniques. DNA-binding properties of the complex were studied using UV-vis spectra, circular dichroism (CD) spectra, fluorescence, cyclic voltammetry (CV), and viscosity measurements. The results indicate that this zinc(II) complex can intercalate into the stacked base pairs of DNA and compete with the strong intercalator ethidium bromide for the intercalative binding sites. PMID:22956919

7 CFR 917.110 - Communications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 8 2012-01-01 2012-01-01 false Communications. 917.110 Section 917.110 Agriculture... CALIFORNIA Rules and Regulations General § 917.110 Communications. Unless otherwise prescribed in this... commodity committee, all reports, applications, submittals, requests, and communications in connection with...

7 CFR 917.110 - Communications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 8 2013-01-01 2013-01-01 false Communications. 917.110 Section 917.110 Agriculture... CALIFORNIA Rules and Regulations General § 917.110 Communications. Unless otherwise prescribed in this... commodity committee, all reports, applications, submittals, requests, and communications in connection with...

10 CFR 51.110 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false [Reserved] 51.110 Section 51.110 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) Rulemaking § 51.110...

47 CFR 301.110 - Organization and operations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Organization and operations. 301.110 Section 301.110 Telecommunication NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE RELOCATION OF AND SPECTRUM SHARING BY FEDERAL GOVERNMENT STATIONS Technical Panel § 301.110...

47 CFR 301.110 - Organization and operations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Organization and operations. 301.110 Section 301.110 Telecommunication NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE RELOCATION OF AND SPECTRUM SHARING BY FEDERAL GOVERNMENT STATIONS Technical Panel § 301.110...

7 CFR 917.110 - Communications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Communications. 917.110 Section 917.110 Agriculture... CALIFORNIA Rules and Regulations General § 917.110 Communications. Unless otherwise prescribed in this... commodity committee, all reports, applications, submittals, requests, and communications in connection with...

10 CFR 51.110 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false [Reserved] 51.110 Section 51.110 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) Rulemaking § 51.110...

7 CFR 917.110 - Communications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Communications. 917.110 Section 917.110 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... CALIFORNIA Rules and Regulations General § 917.110 Communications. Unless otherwise prescribed in this...

22 CFR 513.110 - Coverage.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Coverage. 513.110 Section 513.110 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) General § 513.110 Coverage. (a) These regulations...

22 CFR 513.110 - Coverage.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Coverage. 513.110 Section 513.110 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) General § 513.110 Coverage. (a) These regulations...

22 CFR 513.110 - Coverage.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Coverage. 513.110 Section 513.110 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) General § 513.110 Coverage. (a) These regulations...

22 CFR 513.110 - Coverage.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Coverage. 513.110 Section 513.110 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) General § 513.110 Coverage. (a) These regulations...

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

PubMed Central

Cizmecioglu, Onur; Ni, Jing; Xie, Shaozhen; Zhao, Jean J; Roberts, Thomas M

2016-01-01

We aimed to understand how spatial compartmentalization in the plasma membrane might contribute to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110α and p110β. We found that p110β localizes to membrane rafts in a Rac1-dependent manner. This localization potentiates Akt activation by G-protein-coupled receptors (GPCRs). Thus genetic targeting of a Rac1 binding-deficient allele of p110β to rafts alleviated the requirement for p110β-Rac1 association for GPCR signaling, cell growth and migration. In contrast, p110α, which does not play a physiological role in GPCR signaling, is found to reside in nonraft regions of the plasma membrane. Raft targeting of p110α allowed its EGFR-mediated activation by GPCRs. Notably, p110β dependent, PTEN null tumor cells critically rely upon raft-associated PI3K activity. Collectively, our findings provide a mechanistic account of how membrane raft localization regulates differential activation of distinct PI3K isoforms and offer insight into why PTEN-deficient cancers depend on p110β. DOI: http://dx.doi.org/10.7554/eLife.17635.001 PMID:27700986

The Goodrich 3rd generation DB-110 system: operational on tactical and unmanned aircraft

NASA Astrophysics Data System (ADS)

Iyengar, Mrinal; Lange, Davis

2006-05-01

Goodrich's DB-110 Reconnaissance Airborne Pod for TORnado (RAPTOR) and Data Link Ground Station (DLGS) have been used operationally for several years by the Royal Air Force (RAF). A variant of the RAPTOR DB-110 Sensor System is currently being used by the Japan Maritime Self Defense Force (JMSDF). Recently, the DB-110 system was flown on the Predator B Unmanned Aerial Vehicle (UAV), demonstrating the DB-110 system's utility on unmanned reconnaissance aircraft. The DB-110 is a dual-band EO and IR imaging capability for long, medium, and short standoff ranges, including oblique and over-flight imaging, in a single sensor package. The DB-110 system has also proven performance for real-time high bandwidth data link imagery transmission. Goodrich has leveraged this operational experience in building a 3rd Generation DB-110 system including new Reconnaissance Airborne Pod and Ground System, to be first used by the Polish Air Force. This 3rd Generation system maintains all the capability of the current 2nd Generation DB-110 system and adds several new features. The 3rd Generation system upgrades include an increase in resolution via new focal planes, addition of a third ("super-wide") field of view, and new avionics. This paper summarizes the Goodrich DB-110 3rd Generation System in terms of its basic design and capabilities. Recent demonstration of the DB-110 on the Predator B UAV is overviewed including sample imagery.

Expression and prognostic role of orphan receptor GPR110 in glioma.

PubMed

Shi, Haiping; Zhang, Shiyuan

2017-09-16

Glioma is the most common type of malignancy in the central nervous system, which has a poor prognosis due to its rapid progression and diffuse invasion. Identification of novel biomarkers for glioma would be invaluable for studying disease mechanism and improving prognosis. Orphan G protein-coupled receptor 110 (GPR110) belongs to the subfamily VI of adhesion GPCR. The knowledge of the ligand, signaling pathway or physiology function of GPR110 is poorly elucidated. The potential role of GPR110 as an oncogene in mouse has been recently reported by mutagenesis screen. However, its expression and role in human glioma hasn't been identified. Here in the current study, we initially explored the RNA and protein expression of GPR110 in patients with glioma. Statistical analysis proved that GPR110 was highly expressed in some patients, which was correlated with advanced disease stages. Furthermore, univariate and multivariate analyses revealed its role as an independent prognostic biomarker for the overall survival of glioma patients. Interestingly, cellular studies showed that overexpression or knockdown of GPR110 in U87 cells didn't affect cell proliferation and migration. However, the invasion of U87 cells was significantly enhanced by GPR110-overepxression, while inhibited by GPR110-knockdown. The detailed mechanisms remain further investigation although our results suggested the possible participation of STAT3 instead of ERK in the GPR110 signaling pathways. Copyright © 2017 Elsevier Inc. All rights reserved.

Temperature effects on cathodoluminescence of enstatite

NASA Astrophysics Data System (ADS)

Ohgo, S.; Nishido, H.

2017-12-01

Cathodoluminescence (CL) of enstatite has been extensively investigated for planetary science applications. The CL features are affected by many factors of impurities such as transition metal elements, structural defects and sample temperature. However, the temperature effects on enstatite CL have not been clarified so far. In this study, we have quantitatively evaluated temperature effects on enstatite CL. Three samples of luminescent enstatite were employed for CL spectral measurements. Color CL imaging was carried out using a cold-cathode type Luminoscope with a cooled-CCD camera. CL spectroscopy was made by a SEM-CL system, which is comprised of SEM (JEOL: JSM-5410LV) combined with a grating monochromator (OXFORD: Mono CL2). The CL emitted from the sample was collected in the range of 300-800 nm with a photomultiplier tube by a photon counting method at various temperatures from -193-50 degree C. All CL spectra were corrected for total instrumental response. Color CL imaging reveals various CL emissions with red, reddish-purple and bluish-purple in the terrestrial and extraterrestrial enstatite. All of them have two broad emission bands at around 400 nm in a blue region and at around 670 nm in a red region at room and liquid nitrogen temperatures. The spectral peak in a red region is sharpened and enhanced at lower temperature due to reduction of thermal lattice vibration and an increase in luminescent efficiency. CL intensity at around 670 nm of enstatite decreases with an increase in sample temperature up to -110 degree C from -193 degree C, and increases with an increase in sample temperature between -110 and 50 degree C. This behavior is not able to be explained by a temperature quenching theory based on an increase in the probability of non-radiative transition with the rise of temperature. A least-square fitting of the Arrhenius plot by assuming a Mott-Seitz model provides an activation energy of less than 0.01 eV in temperature quenching process from -193 to -110 degree C. According to an analytical method proposed by Barnett and Bailiff (1996), an activation energy of 0.03-0.16 eV can be estimated as a sensitizing effect on the CL from -110 up to 50 degree C. The unusual sensitizing effect has not been reported so far in the pyroxene minerals.

Tracing cadmium, zinc and lead sources in bivalves from the coasts of western Canada and the USA using isotopes

NASA Astrophysics Data System (ADS)

Shiel, Alyssa E.; Weis, Dominique; Orians, Kristin J.

2012-01-01

Environmental monitoring and remediation require techniques to identify the source and fate of metals emissions. The measurement of heavy metal isotopic signatures, made possible by the advent of the MC-ICP-MS, is a powerful new geochemical tool, which may be used to trace the source of these metals in the environment. In a multi-tracer study, Cd, Zn and Pb isotopic compositions (MC-ICP-MS) and elemental concentrations (HR-ICP-MS) are used to distinguish between natural and anthropogenic sources of these metals in bivalves collected from western Canada (British Columbia), Hawaii, and the USA East Coast. Variability in the δ 114/110Cd values of bivalves (-1.20‰ to -0.09‰) is attributed to differences in the relative contributions of Cd from natural and anthropogenic sources between sites. Cadmium isotopic compositions (δ 114/110Cd = -0.69‰ to -0.09‰) identify high Cd levels in B.C. oysters as primarily natural (i.e., upwelling of Cd rich intermediate waters in the North Pacific), with some variability attributed to anthropogenic sources (e.g., mining and smelting). Variability in the δ 66/64Zn values exhibited by the B.C. bivalves is relatively small (0.28-0.36‰). Despite the low Pb levels found in B.C. oysters, Pb isotopes are used to identify emissions from industrial processes and the consumption of unleaded gasoline and diesel fuel as significant metal sources. Although the Cd concentrations of the USA East Coast bivalves are primarily lower than those of B.C. oysters, their relatively light Cd isotopic compositions (δ 114/110Cd = -1.20‰ to -0.54‰) indicate the significance of anthropogenic Cd sources and are attributed to the high prevalence of industry on this coast. The δ 114/110Cd values of USA East Coast bivalves include the lightest ever reported, with the exception of values reported for extraterrestrial materials. In addition, the Pb isotopic compositions of bivalves from the USA East Coast indicate Pb emissions from the combustion of coal are an important source of Pb, consistent with the high consumption of coal for power production on this coast. This study demonstrates the effective use of Cd and Zn isotopes to trace anthropogenic sources in the environment and the benefit of combining these tools with Pb "fingerprinting" techniques.

10 CFR 110.29 - Restricted destinations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel Libya...

7 CFR 1280.110 - Information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Information. 1280.110 Section 1280.110 Agriculture... INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.110 Information. Information means information and programs that are designed to increase efficiency in producing lambs, to...

7 CFR 1280.110 - Information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Information. 1280.110 Section 1280.110 Agriculture... INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.110 Information. Information means information and programs that are designed to increase efficiency in producing lambs, to...

7 CFR 1280.110 - Information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Information. 1280.110 Section 1280.110 Agriculture... INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.110 Information. Information means information and programs that are designed to increase efficiency in producing lambs, to...

7 CFR 1280.110 - Information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Information. 1280.110 Section 1280.110 Agriculture... INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.110 Information. Information means information and programs that are designed to increase efficiency in producing lambs, to...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.29 - Restricted destinations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel Libya...

10 CFR 110.29 - Restricted destinations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel Libya...

10 CFR 110.29 - Restricted destinations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel Libya...

10 CFR 110.29 - Restricted destinations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Restricted destinations. 110.29 Section 110.29 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Licenses § 110.29 Restricted destinations. Afghanistan Andorra Angola Burma (Myanmar) Djibouti India Israel Libya...

7 CFR 1280.110 - Information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Information. 1280.110 Section 1280.110 Agriculture... INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.110 Information. Information means information and programs that are designed to increase efficiency in producing lambs, to...

10 CFR 110.4 - Communications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Communications. 110.4 Section 110.4 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.4 Communications. Except where otherwise specified in this part, all communications and reports...

10 CFR 110.4 - Communications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Communications. 110.4 Section 110.4 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.4 Communications. Except where otherwise specified in this part, all communications and reports...

40 CFR 415.110 - Applicability; description of the potassium metal production subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... potassium metal production subcategory. 415.110 Section 415.110 Protection of Environment ENVIRONMENTAL... SOURCE CATEGORY Potassium Metal Production Subcategory § 415.110 Applicability; description of the potassium metal production subcategory. The provisions of this subpart are applicable to discharges...

40 CFR 415.110 - Applicability; description of the potassium metal production subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... potassium metal production subcategory. 415.110 Section 415.110 Protection of Environment ENVIRONMENTAL... SOURCE CATEGORY Potassium Metal Production Subcategory § 415.110 Applicability; description of the potassium metal production subcategory. The provisions of this subpart are applicable to discharges...

40 CFR 415.110 - Applicability; description of the potassium metal production subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... potassium metal production subcategory. 415.110 Section 415.110 Protection of Environment ENVIRONMENTAL... SOURCE CATEGORY Potassium Metal Production Subcategory § 415.110 Applicability; description of the potassium metal production subcategory. The provisions of this subpart are applicable to discharges...

40 CFR 415.110 - Applicability; description of the potassium metal production subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... potassium metal production subcategory. 415.110 Section 415.110 Protection of Environment ENVIRONMENTAL... SOURCE CATEGORY Potassium Metal Production Subcategory § 415.110 Applicability; description of the potassium metal production subcategory. The provisions of this subpart are applicable to discharges...

40 CFR 415.110 - Applicability; description of the potassium metal production subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... potassium metal production subcategory. 415.110 Section 415.110 Protection of Environment ENVIRONMENTAL... SOURCE CATEGORY Potassium Metal Production Subcategory § 415.110 Applicability; description of the potassium metal production subcategory. The provisions of this subpart are applicable to discharges...

10 CFR 110.4 - Communications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Communications. 110.4 Section 110.4 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL General Provisions § 110.4 Communications. Except where otherwise specified in this part, all communications and reports...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

10 CFR 110.122 - Classification assistance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Classification assistance. 110.122 Section 110.122 Energy... Procedures for Classified Information in Hearings § 110.122 Classification assistance. On the request of any... security classification of information and the protective requirements to be observed. ...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

42 CFR 401.110 - Publications for sale.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 2 2012-10-01 2012-10-01 false Publications for sale. 401.110 Section 401.110... PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.110 Publications for sale. The following publications containing information pertaining to the program, organization, functions...

42 CFR 401.110 - Publications for sale.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 2 2013-10-01 2013-10-01 false Publications for sale. 401.110 Section 401.110... PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.110 Publications for sale. The following publications containing information pertaining to the program, organization, functions...

Ovarian FAM110C (Family with Sequence Similarity 110C): Induction During the Periovulatory Period and Regulation of Granulosa Cell Cycle Kinetics in Rats1

PubMed Central

Li, Feixue; Jang, Hyein; Puttabyatappa, Muraly; Jo, Misung; Curry,, Thomas E.

2012-01-01

ABSTRACT FAM110C belongs to a family of proteins that regulates cell proliferation. In the present study, the spatiotemporal expression pattern of FAM110C and its potential role were examined during the periovulatory period. Immature female rats were injected with equine chorionic gonadotropin (eCG) followed by human chorionic gonadotropin (hCG) and ovaries or granulosa cells were collected at various times after hCG administration (n = 3/time point). Expression levels of Fam110c mRNA and protein were highly induced both in intact ovaries and granulosa cells at 8 to 12 h after hCG treatment. In situ hybridization analysis demonstrated Fam110c mRNA expression was induced in theca and granulosa cells at 4 h after hCG, primarily localized to granulosa cells at 8 h and 12 h, and decreased at 24 h after hCG. There was negligible Fam110c mRNA detected in newly forming corpora lutea. In rat granulosa cell cultures, hCG induced expression of Fam110c mRNA was inhibited by RU486, whereas NS398 and AG1478 had no effect, suggesting that Fam110c expression is regulated in part by the progesterone receptor pathway. Promoter activity analysis revealed that an Sp1 site was important for the induction of Fam110c expression by hCG. Overexpression of FAM110C promoted granulosa cells to arrest at the G1 phase of the cell cycle but did not change progesterone levels. In summary, hCG induces Fam110c mRNA expression in granulosa cells by activation of an Sp1-binding site and the actions of progesterone. Our findings suggest that FAM110C may control granulosa cell differentiation into luteal cells by arresting cell cycle progression. PMID:22460667

[Clinical significance and mechanism of upregulation of PI3Kp110α in non-small cell lung carcinoma].

PubMed

Xiong, Y; Qu, L L; Li, D; Wang, Y; Li, T

2017-10-23

Objective: To investigate the clinical significance and mechanism of upregulation of phosphoinositide 3-kinase p110α(PI3Kp110α)in non-small cell lung carcinoma (NSCLC). Methods: Expressions of PI3Kp110α and other components in PI3K signaling pathway (including phospho-Akt (p-Akt, Ser 473), MET, ROS1, HER-2, ALK, total EGFR and mutant EGFR) and p53 (the transcription factor of PIK3CA) mutation in NSCLC were detected by immunohistochemistry. The relationships between PI3Kp110α expression and clinicopathological characteristics, expressions of other proteins in PI3K pathway and p53 mutation were analyzed. Results: In 170 NSCLC patients, 72 cases (42.4%) showed lower expression and 98 cases (57.6%) showed higher expression of PI3Kp110α. Upregulation of PI3Kp110α was not significantly associated with gender, age, T stage and pathologic grade ( P >0.05). While upregulation of PI3Kp110α was significantly associated with smoking status of patients, pathologic classification, N stage, TNM stage and Ki-67 index ( P <0.05). Expression of PI3Kp110α was positively correlated with expressions of MET ( P <0.05) and mutant EGFR ( P =0.018), while not significantly related with expressions of p-Akt(Ser473), HER-2, ALK, ROS1, total EGFR or p53 mutation ( P >0.05). Conclusions: Upregulation of PI3Kp110α is closely related with tumorigenesis of non-smoking lung adenocarcinoma. MET overexpression and EGFR mutation may be crucial to upregulate expression of PI3Kp110α in NSCLC. Overexpression of PI3Kp110α may inhibit tumor cell proliferation in NSCLC through a different pathway other than classical PI3K pathway. Upregulation of PI3Kp110α may predict favorable prognosis of NSCLC patients.

41 CFR 115-1.110 - Deviations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Deviations. 115-1.110 Section 115-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) ENVIRONMENTAL PROTECTION AGENCY 1-INTRODUCTION 1.1-Regulation System § 115-1.110 Deviations...

7 CFR 29.110 - Method of sampling.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Method of sampling. 29.110 Section 29.110 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Inspectors, Samplers, and Weighers § 29.110 Method of sampling. In sampling tobacco...

24 CFR 572.110 - Identifying and selecting eligible families for homeownership.

Code of Federal Regulations, 2011 CFR

2011-04-01

... families for homeownership. 572.110 Section 572.110 Housing and Urban Development Regulations Relating to... FAMILY HOMES PROGRAM (HOPE 3) Homeownership Program Requirements-Implementation Grants § 572.110 Identifying and selecting eligible families for homeownership. (a) Selection procedures. (1) Recipients must...

7 CFR 29.110 - Method of sampling.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Method of sampling. 29.110 Section 29.110 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Inspectors, Samplers, and Weighers § 29.110 Method of sampling. In sampling tobacco...

42 CFR 401.110 - Publications for sale.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Publications for sale. 401.110 Section 401.110 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.110 Publications for sale...

44 CFR 16.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Self-evaluation. 16.110 Section 16.110 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... ACTIVITIES CONDUCTED BY THE FEDERAL EMERGENCY MANAGEMENT AGENCY § 16.110 Self-evaluation. (a) The agency...

33 CFR 110.26 - Marblehead Harbor, Marblehead, Mass.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marblehead Harbor, Marblehead, Mass. 110.26 Section 110.26 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.26 Marblehead Harbor, Marblehead...

33 CFR 110.26 - Marblehead Harbor, Marblehead, Mass.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marblehead Harbor, Marblehead, Mass. 110.26 Section 110.26 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.26 Marblehead Harbor, Marblehead...

33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

33 CFR 110.26 - Marblehead Harbor, Marblehead, Mass.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marblehead Harbor, Marblehead, Mass. 110.26 Section 110.26 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.26 Marblehead Harbor, Marblehead...

33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

33 CFR 110.26 - Marblehead Harbor, Marblehead, Mass.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marblehead Harbor, Marblehead, Mass. 110.26 Section 110.26 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.26 Marblehead Harbor, Marblehead...

33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

33 CFR 110.26 - Marblehead Harbor, Marblehead, Mass.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marblehead Harbor, Marblehead, Mass. 110.26 Section 110.26 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.26 Marblehead Harbor, Marblehead...

33 CFR 110.231 - Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Passenger Vessel Anchorage. 110.231 Section 110.231 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.231 Ketchikan Harbor, Alaska, Large Passenger Vessel Anchorage. (a) The anchorage grounds. Ketchikan Harbor, Alaska, Large...

32 CFR 110.6 - Information requirement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Information requirement. 110.6 Section 110.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... RESERVE OFFICERS' TRAINING CORPS § 110.6 Information requirement. The reporting requirement for paragraph...

22 CFR 1103.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Self-evaluation. 1103.110 Section 1103.110 Foreign Relations INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES... INTERNATIONAL BOUNDARY AND WATER COMMISSION, UNITED STATES AND MEXICO, UNITED STATES SECTION § 1103.110 Self...

10 CFR 110.81 - Written comments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Written comments. 110.81 Section 110.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Public Participation Procedures Concerning License Applications § 110.81 Written comments. (a) The Commission encourages written...

32 CFR 110.6 - Information requirement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Information requirement. 110.6 Section 110.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN... RESERVE OFFICERS' TRAINING CORPS § 110.6 Information requirement. The reporting requirement for paragraph...

7 CFR 922.110 - Container exemption.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Container exemption. 922.110 Section 922.110... COUNTIES IN WASHINGTON Container Exemption; Waivers of Inspection and Certification § 922.110 Container exemption. Whenever container limitations are effective pursuant to § 922.52, a handler may make test...

16 CFR 6.110 - Self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Self-evaluation. 6.110 Section 6.110 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ENFORCEMENT OF....110 Self-evaluation. (a) The Commission shall, by February 1, 1989, evaluate its current policies and...

49 CFR 1014.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... or organizations representing handicapped persons, to participate in the self-evaluation process by... 49 Transportation 8 2014-10-01 2014-10-01 false Self-evaluation. 1014.110 Section 1014.110... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE SURFACE TRANSPORTATION BOARD § 1014.110 Self-evaluation...

49 CFR 807.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Self-evaluation. 807.110 Section 807.110... TRANSPORTATION SAFETY BOARD § 807.110 Self-evaluation. (a) The agency shall, by April 9, 1987, evaluate its... interested persons, including handicapped persons or organizations representing handicapped persons, to...

40 CFR 12.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... organizations representing individuals with handicaps to, participate in the self-evaluation process by... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Self-evaluation. 12.110 Section 12.110... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION AGENCY § 12.110 Self-evaluation...

22 CFR 219.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Self-evaluation. 219.110 Section 219.110... INTERNATIONAL DEVELOPMENT § 219.110 Self-evaluation. (a) The agency shall, by April 9, 1987, evaluate its... interested persons, including handicapped persons or organizations representing handicapped persons, to...

16 CFR 6.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Self-evaluation. 6.110 Section 6.110 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ENFORCEMENT OF....110 Self-evaluation. (a) The Commission shall, by February 1, 1989, evaluate its current policies and...

16 CFR 6.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Self-evaluation. 6.110 Section 6.110 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ENFORCEMENT OF....110 Self-evaluation. (a) The Commission shall, by February 1, 1989, evaluate its current policies and...

40 CFR 110.4 - Dispersants.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Dispersants. 110.4 Section 110.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DISCHARGE OF OIL § 110.4 Dispersants. Addition of dispersants or emulsifiers to oil to be discharged that would circumvent the...

40 CFR 110.4 - Dispersants.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Dispersants. 110.4 Section 110.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DISCHARGE OF OIL § 110.4 Dispersants. Addition of dispersants or emulsifiers to oil to be discharged that would circumvent the...

24 CFR 100.110 - Discriminatory practices in residential real estate-related transactions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... residential real estate-related transactions. 100.110 Section 100.110 Housing and Urban Development... Discrimination in Residential Real Estate-Related Transactions § 100.110 Discriminatory practices in residential real estate-related transactions. (a) This subpart provides the Department's interpretation of the...

24 CFR 100.110 - Discriminatory practices in residential real estate-related transactions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... residential real estate-related transactions. 100.110 Section 100.110 Housing and Urban Development... Discrimination in Residential Real Estate-Related Transactions § 100.110 Discriminatory practices in residential real estate-related transactions. (a) This subpart provides the Department's interpretation of the...

24 CFR 100.110 - Discriminatory practices in residential real estate-related transactions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... residential real estate-related transactions. 100.110 Section 100.110 Housing and Urban Development... Discrimination in Residential Real Estate-Related Transactions § 100.110 Discriminatory practices in residential real estate-related transactions. (a) This subpart provides the Department's interpretation of the...

24 CFR 100.110 - Discriminatory practices in residential real estate-related transactions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... residential real estate-related transactions. 100.110 Section 100.110 Housing and Urban Development... Discrimination in Residential Real Estate-Related Transactions § 100.110 Discriminatory practices in residential real estate-related transactions. (a) This subpart provides the Department's interpretation of the...

24 CFR 100.110 - Discriminatory practices in residential real estate-related transactions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... residential real estate-related transactions. 100.110 Section 100.110 Housing and Urban Development... Discrimination in Residential Real Estate-Related Transactions § 100.110 Discriminatory practices in residential real estate-related transactions. (a) This subpart provides the Department's interpretation of the...

42 CFR 494.110 - Condition: Quality assessment and performance improvement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... improvement. 494.110 Section 494.110 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... RENAL DISEASE FACILITIES Patient Care § 494.110 Condition: Quality assessment and performance... renal bone disease. (iv) Anemia management. (v) Vascular access. (vi) Medical injuries and medical...

42 CFR 494.110 - Condition: Quality assessment and performance improvement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... improvement. 494.110 Section 494.110 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... RENAL DISEASE FACILITIES Patient Care § 494.110 Condition: Quality assessment and performance... renal bone disease. (iv) Anemia management. (v) Vascular access. (vi) Medical injuries and medical...

42 CFR 494.110 - Condition: Quality assessment and performance improvement.

Code of Federal Regulations, 2012 CFR

2012-10-01

... improvement. 494.110 Section 494.110 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... RENAL DISEASE FACILITIES Patient Care § 494.110 Condition: Quality assessment and performance... renal bone disease. (iv) Anemia management. (v) Vascular access. (vi) Medical injuries and medical...

49 CFR 28.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Self-evaluation. 28.110 Section 28.110 Transportation Office of the Secretary of Transportation ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28.110 Self-evaluation...

1 CFR 500.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Self-evaluation. 500.110 Section 500.110... PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL COMMISSION FOR EMPLOYMENT POLICY § 500.110 Self-evaluation... or organizations representing handicapped persons, to participate in the self-evaluation process by...

49 CFR 1014.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false Self-evaluation. 1014.110 Section 1014.110... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE SURFACE TRANSPORTATION BOARD § 1014.110 Self-evaluation... or organizations representing handicapped persons, to participate in the self-evaluation process by...

1 CFR 457.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Self-evaluation. 457.110 Section 457.110... PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL CAPITAL PLANNING COMMISSION § 457.110 Self-evaluation. (a... organizations representing handicapped persons, to participate in the self-evaluation process by submitting...

22 CFR 1510.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Self-evaluation. 1510.110 Section 1510.110... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE AFRICAN DEVELOPMENT FOUNDATION § 1510.110 Self-evaluation... handicaps or organizations representing individuals with handicaps, to participate in the self-evaluation...

16 CFR 1034.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Self-evaluation. 1034.110 Section 1034.110 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE CONSUMER PRODUCT SAFETY COMMISSION § 1034.110...

42 CFR 110.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Purpose. 110.1 Section 110.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM General Provisions § 110.1 Purpose. This part implements the Public Readiness and Emergency...

42 CFR 110.74 - Disapproval of benefits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Disapproval of benefits. 110.74 Section 110.74 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.74 Disapproval of benefits. (a) If the...

42 CFR 110.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Purpose. 110.1 Section 110.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM General Provisions § 110.1 Purpose. This part implements the Public Readiness and Emergency...

42 CFR 110.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Purpose. 110.1 Section 110.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM General Provisions § 110.1 Purpose. This part implements the Public Readiness and Emergency...

42 CFR 110.31 - Medical benefits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Medical benefits. 110.31 Section 110.31 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Available Benefits § 110.31 Medical benefits. (a) Injured countermeasure recipients may...

42 CFR 110.31 - Medical benefits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Medical benefits. 110.31 Section 110.31 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Available Benefits § 110.31 Medical benefits. (a) Injured countermeasure recipients may...

42 CFR 110.74 - Disapproval of benefits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Disapproval of benefits. 110.74 Section 110.74 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.74 Disapproval of benefits. (a) If the...

42 CFR 110.31 - Medical benefits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Medical benefits. 110.31 Section 110.31 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Available Benefits § 110.31 Medical benefits. (a) Injured countermeasure recipients may...

42 CFR 110.74 - Disapproval of benefits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Disapproval of benefits. 110.74 Section 110.74 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.74 Disapproval of benefits. (a) If the...

42 CFR 110.74 - Disapproval of benefits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Disapproval of benefits. 110.74 Section 110.74 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.74 Disapproval of benefits. (a) If the...

42 CFR 110.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Purpose. 110.1 Section 110.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM General Provisions § 110.1 Purpose. This part implements the Public Readiness and Emergency...

42 CFR 110.31 - Medical benefits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Medical benefits. 110.31 Section 110.31 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Available Benefits § 110.31 Medical benefits. (a) Injured countermeasure recipients may...

40 CFR 110.4 - Dispersants.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Dispersants. 110.4 Section 110.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DISCHARGE OF OIL § 110.4 Dispersants. Addition of dispersants or emulsifiers to oil to be discharged that would circumvent the...

40 CFR 110.4 - Dispersants.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Dispersants. 110.4 Section 110.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DISCHARGE OF OIL § 110.4 Dispersants. Addition of dispersants or emulsifiers to oil to be discharged that would circumvent the...

40 CFR 110.4 - Dispersants.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Dispersants. 110.4 Section 110.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DISCHARGE OF OIL § 110.4 Dispersants. Addition of dispersants or emulsifiers to oil to be discharged that would circumvent the...

46 CFR 403.110 - Accounting entities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Accounting entities. 403.110 Section 403.110 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE UNIFORM ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate accounting...

p110α and p110β isoforms of PI3K signaling: are they two sides of the same coin?

PubMed

Singh, Paramjeet; Dar, Mohd Saleem; Dar, Mohd Jamal

2016-09-01

Class-1 phosphatidylinositol-3-kinases (PI3Ks) are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes. p110α and p110β are the two most studied isoforms of the class-1A PI3K signaling pathway. Although these two isoforms are ubiquitously expressed and play multiple redundant roles, they also have distinct functions within the cell. More recently, p110α and p110β isoforms have been shown to translocate into the nucleus and play a role in DNA replication and repair, and in cell cycle progression. In the following Review article, we discuss the overlapping and unique roles of p110α and p110β isoforms with a particular focus on their structure, expression analysis, subcellular localization, and signaling contributions in various cell types and model organisms. © 2016 Federation of European Biochemical Societies.

Electrophysiological approach to determine kinetic parameters of sucrose uptake by single sieve elements or phloem parenchyma cells in intact Vicia faba plants.

PubMed

Hafke, Jens B; Höll, Sabina-Roxana; Kühn, Christina; van Bel, Aart J E

2013-01-01

Apart from cut aphid stylets in combination with electrophysiology, no attempts have been made thus far to measure in vivo sucrose-uptake properties of sieve elements. We investigated the kinetics of sucrose uptake by single sieve elements and phloem parenchyma cells in Vicia faba plants. To this end, microelectrodes were inserted into free-lying phloem cells in the main vein of the youngest fully-expanded leaf, half-way along the stem, in the transition zone between the autotrophic and heterotrophic part of the stem, and in the root axis. A top-to-bottom membrane potential gradient of sieve elements was observed along the stem (-130 mV to -110 mV), while the membrane potential of the phloem parenchyma cells was stable (approx. -100 mV). In roots, the membrane potential of sieve elements dropped abruptly to -55 mV. Bathing solutions having various sucrose concentrations were administered and sucrose/H(+)-induced depolarizations were recorded. Data analysis by non-linear least-square data fittings as well as by linear Eadie-Hofstee (EH) -transformations pointed at biphasic Michaelis-Menten kinetics (2 MM, EH: K m1 1.2-1.8 mM, K m2 6.6-9.0 mM) of sucrose uptake by sieve elements. However, Akaike's Information Criterion (AIC) favored single MM kinetics. Using single MM as the best-fitting model, K m values for sucrose uptake by sieve elements decreased along the plant axis from 1 to 7 mM. For phloem parenchyma cells, higher K m values (EH: K m1 10 mM, K m2 70 mM) as compared to sieve elements were found. In preliminary patch-clamp experiments with sieve-element protoplasts, small sucrose-coupled proton currents (-0.1 to -0.3 pA/pF) were detected in the whole-cell mode. In conclusion (a) K m values for sucrose uptake measured by electrophysiology are similar to those obtained with heterologous systems, (b) electrophysiology provides a useful tool for in situ determination of K m values, (c) As yet, it remains unclear if one or two uptake systems are involved in sucrose uptake by sieve elements, (d) Affinity for sucrose uptake by sieve elements exceeds by far that by phloem parenchyma cells, (e) Patch-clamp studies provide a feasible basis for quantification of sucrose uptake by single cells. The consequences of the findings for whole-plant carbohydrate partitioning are discussed.

Electrophysiological approach to determine kinetic parameters of sucrose uptake by single sieve elements or phloem parenchyma cells in intact Vicia faba plants

PubMed Central

Hafke, Jens B.; Höll, Sabina-Roxana; Kühn, Christina; van Bel, Aart J. E.

2013-01-01

Apart from cut aphid stylets in combination with electrophysiology, no attempts have been made thus far to measure in vivo sucrose-uptake properties of sieve elements. We investigated the kinetics of sucrose uptake by single sieve elements and phloem parenchyma cells in Vicia faba plants. To this end, microelectrodes were inserted into free-lying phloem cells in the main vein of the youngest fully-expanded leaf, half-way along the stem, in the transition zone between the autotrophic and heterotrophic part of the stem, and in the root axis. A top-to-bottom membrane potential gradient of sieve elements was observed along the stem (−130 mV to −110 mV), while the membrane potential of the phloem parenchyma cells was stable (approx. −100 mV). In roots, the membrane potential of sieve elements dropped abruptly to −55 mV. Bathing solutions having various sucrose concentrations were administered and sucrose/H+-induced depolarizations were recorded. Data analysis by non-linear least-square data fittings as well as by linear Eadie–Hofstee (EH) -transformations pointed at biphasic Michaelis–Menten kinetics (2 MM, EH: Km1 1.2–1.8 mM, Km2 6.6–9.0 mM) of sucrose uptake by sieve elements. However, Akaike's Information Criterion (AIC) favored single MM kinetics. Using single MM as the best-fitting model, Km values for sucrose uptake by sieve elements decreased along the plant axis from 1 to 7 mM. For phloem parenchyma cells, higher Km values (EH: Km1 10 mM, Km2 70 mM) as compared to sieve elements were found. In preliminary patch-clamp experiments with sieve-element protoplasts, small sucrose-coupled proton currents (−0.1 to −0.3 pA/pF) were detected in the whole-cell mode. In conclusion (a) Km values for sucrose uptake measured by electrophysiology are similar to those obtained with heterologous systems, (b) electrophysiology provides a useful tool for in situ determination of Km values, (c) As yet, it remains unclear if one or two uptake systems are involved in sucrose uptake by sieve elements, (d) Affinity for sucrose uptake by sieve elements exceeds by far that by phloem parenchyma cells, (e) Patch-clamp studies provide a feasible basis for quantification of sucrose uptake by single cells. The consequences of the findings for whole-plant carbohydrate partitioning are discussed. PMID:23914194

The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells

PubMed Central

Ivison, Sabine M.; Khan, Mohammed A. S.; Graham, Nicholas R.; Shobab, Leila A.; Yao, Yu; Kifayet, Arnawaz; Sly, Laura M.; Steiner, Theodore S.

2010-01-01

Background. Bacterial flagellin triggers inflammation in mammalian cells via Toll-like receptor (TLR) 5. Release of the chemokine IL-8 in response to flagellin involves NF-κB, p38 MAP kinase, and phosphatidylinositol 3-kinase (PI3K). However, PI3K has been reported to be either pro- or anti-inflammatory in different model systems. We hypothesized that this could be due to different activities of the p110α and β isoforms of PI3K. Results. PI3K and Akt were rapidly activated in Caco-2 colon carcinoma cells by flagellin. Using a plasmid-based shRNA delivery system and novel p110 isoform-specific inhibitors, we found that flagellin-induced IL-8 production was dependent on both p110α and p110β. However in the mouse, inhibition of p110β but not p110α reduced the increase of serum IL-6 levels induced by intraperitoneal injection of flagellin. Conclusions. These data demonstrate that the p110α and β isoforms of class IA PI3K are both required for the proinflammatory response to flagellin. PMID:20953381

41 CFR 101-1.110 - Deviation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Deviation. 101-1.110 Section 101-1.110 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101-1.110 Deviation...

41 CFR 105-1.110 - Deviation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Deviation. 105-1.110 Section 105-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.110 Deviation. (a...

34 CFR 300.110 - Program options.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Program options. 300.110 Section 300.110 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Other Fape Requirements § 300.110 Program options. The State must ensure that...

38 CFR 4.110 - Ulcers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Ulcers. 4.110 Section 4.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings The Digestive System § 4.110 Ulcers. Experience has shown that the term “peptic...

42 CFR 136.110 - Facilities construction.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Facilities construction. 136.110 Section 136.110... Facilities and Services § 136.110 Facilities construction. In addition to other requirements of this subpart..., clinic, health station or quarters for housing personnel associated with such facilities, must in its...

33 CFR 110.77 - Amistad Reservoir, Tex.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Amistad Reservoir, Tex. 110.77 Section 110.77 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.77 Amistad Reservoir, Tex. (a) Diablo East, Tex. That...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.77 - Amistad Reservoir, Tex.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Amistad Reservoir, Tex. 110.77 Section 110.77 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.77 Amistad Reservoir, Tex. (a) Diablo East, Tex. That...

33 CFR 110.77 - Amistad Reservoir, Tex.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Amistad Reservoir, Tex. 110.77 Section 110.77 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.77 Amistad Reservoir, Tex. (a) Diablo East, Tex. That...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.67 - Delaware River, Essington, Pa.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Delaware River, Essington, Pa. 110.67 Section 110.67 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.67 Delaware River, Essington, Pa. North of...

33 CFR 110.77 - Amistad Reservoir, Tex.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Amistad Reservoir, Tex. 110.77 Section 110.77 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.77 Amistad Reservoir, Tex. (a) Diablo East, Tex. That...

45 CFR 158.110 - Reporting requirements related to premiums and expenditures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... expenditures. 158.110 Section 158.110 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS Disclosure and Reporting § 158.110 Reporting requirements related to premiums and expenditures. (a) General...

45 CFR 158.110 - Reporting requirements related to premiums and expenditures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... expenditures. 158.110 Section 158.110 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS Disclosure and Reporting § 158.110 Reporting requirements related to premiums and expenditures. (a) General...

45 CFR 158.110 - Reporting requirements related to premiums and expenditures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... expenditures. 158.110 Section 158.110 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS Disclosure and Reporting § 158.110 Reporting requirements related to premiums and expenditures. (a) General...

45 CFR 158.110 - Reporting requirements related to premiums and expenditures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... expenditures. 158.110 Section 158.110 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS ISSUER USE OF PREMIUM REVENUE: REPORTING AND REBATE REQUIREMENTS Disclosure and Reporting § 158.110 Reporting requirements related to premiums and expenditures. (a) General...

7 CFR 1.10 - Search services.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Search services. 1.10 Section 1.10 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.10 Search services. Search services are services of agency personnel—clerical or professional—used in trying to find the...

33 CFR 110.142 - Nantucket Harbor, Mass.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Nantucket Harbor, Mass. 110.142 Section 110.142 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.142 Nantucket Harbor, Mass. (a) The anchorage grounds. In the...

33 CFR 110.138 - Boston Harbor, Mass.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Boston Harbor, Mass. 110.138 Section 110.138 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.138 Boston Harbor, Mass. (a) The anchorage grounds—(1) Bird...

33 CFR 110.142 - Nantucket Harbor, Mass.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Nantucket Harbor, Mass. 110.142 Section 110.142 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.142 Nantucket Harbor, Mass. (a) The anchorage grounds. In the...

7 CFR 4290.110 - Qualified management.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Qualified management. 4290.110 Section 4290.110... Qualifications for the RBIC Program Organizing A Rbic § 4290.110 Qualified management. Link to an amendment..., that its current or proposed management team is qualified and has the knowledge, experience, and...

46 CFR 403.110 - Accounting entities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 8 2011-10-01 2011-10-01 false Accounting entities. 403.110 Section 403.110 Shipping... ACCOUNTING SYSTEM General § 403.110 Accounting entities. Each Association shall be a separate accounting entity. However, the records shall be maintained with sufficient particularity to allocate items to each...

45 CFR 1158.110 - Certification and disclosure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Certification and disclosure. 1158.110 Section 1158.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NEW RESTRICTIONS ON LOBBYING General § 1158.110...

50 CFR 550.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Self-evaluation. 550.110 Section 550.110 Wildlife and Fisheries MARINE MAMMAL COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY MARINE MAMMAL COMMISSION § 550.110 Self-evaluation. (a) The...

32 CFR 1699.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Self-evaluation. 1699.110 Section 1699.110 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ENFORCEMENT OF....110 Self-evaluation. (a) The agency shall, within one year of the effective date of this part...

32 CFR 1699.110 - Self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Self-evaluation. 1699.110 Section 1699.110 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ENFORCEMENT OF....110 Self-evaluation. (a) The agency shall, within one year of the effective date of this part...

32 CFR 1699.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Self-evaluation. 1699.110 Section 1699.110 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ENFORCEMENT OF....110 Self-evaluation. (a) The agency shall, within one year of the effective date of this part...

32 CFR 1699.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Self-evaluation. 1699.110 Section 1699.110 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ENFORCEMENT OF....110 Self-evaluation. (a) The agency shall, within one year of the effective date of this part...

32 CFR 1699.110 - Self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Self-evaluation. 1699.110 Section 1699.110 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ENFORCEMENT OF....110 Self-evaluation. (a) The agency shall, within one year of the effective date of this part...

40 CFR 98.110 - Definition of the source category.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Definition of the source category. 98.110 Section 98.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Ferroalloy Production § 98.110 Definition of the source...

45 CFR 2523.110 - Can Federal agencies submit multiple applications?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Can Federal agencies submit multiple applications? 2523.110 Section 2523.110 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION... AMERICORPS PROGRAM ASSISTANCE § 2523.110 Can Federal agencies submit multiple applications? No. The...

40 CFR 440.110 - Applicability; description of the platinum ore subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... platinum ore subcategory. 440.110 Section 440.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Platinum Ores Subcategory § 440.110 Applicability; description of the platinum ore subcategory. The provisions of this...

40 CFR 440.110 - Applicability; description of the platinum ore subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... platinum ore subcategory. 440.110 Section 440.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Platinum Ores Subcategory § 440.110 Applicability; description of the platinum ore subcategory. The provisions of this...

41 CFR 105-53.110 - Creation and authority.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management... General § 105-53.110 Creation and authority. The General Services Administration was established by...

41 CFR 105-53.110 - Creation and authority.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management... General § 105-53.110 Creation and authority. The General Services Administration was established by...

41 CFR 105-53.110 - Creation and authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management... General § 105-53.110 Creation and authority. The General Services Administration was established by...

42 CFR 412.110 - Total Medicare payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Payments to Hospitals Under the Prospective Payment Systems § 412.110 Total Medicare payment. Under the prospective payment systems, Medicare... 42 Public Health 2 2010-10-01 2010-10-01 false Total Medicare payment. 412.110 Section 412.110...

45 CFR 1175.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... organizations representing handicapped persons, to participate in the self-evaluation process by submitting... 45 Public Welfare 3 2013-10-01 2013-10-01 false Self-evaluation. 1175.110 Section 1175.110 Public... PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL ENDOWMENT FOR THE HUMANITIES § 1175.110 Self-evaluation...

45 CFR 1181.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... or organizations representing handicapped persons, to participate in the self-evaluation process by... 45 Public Welfare 3 2013-10-01 2013-10-01 false Self-evaluation. 1181.110 Section 1181.110 Public... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE INSTITUTE OF MUSEUM AND LIBRARY SERVICES § 1181.110 Self...

45 CFR 1175.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... organizations representing handicapped persons, to participate in the self-evaluation process by submitting... 45 Public Welfare 3 2014-10-01 2014-10-01 false Self-evaluation. 1175.110 Section 1175.110 Public... PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL ENDOWMENT FOR THE HUMANITIES § 1175.110 Self-evaluation...

46 CFR 507.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... or organizations representing handicapped persons, to participate in the self-evaluation process by... 46 Shipping 9 2014-10-01 2014-10-01 false Self-evaluation. 507.110 Section 507.110 Shipping... BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL MARITIME COMMISSION § 507.110 Self...

22 CFR 144.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... or organizations representing handicapped persons, to participate in the self-evaluation process by... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Self-evaluation. 144.110 Section 144.110... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF STATE § 144.110 Self...

45 CFR 1181.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... or organizations representing handicapped persons, to participate in the self-evaluation process by... 45 Public Welfare 3 2014-10-01 2014-10-01 false Self-evaluation. 1181.110 Section 1181.110 Public... IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE INSTITUTE OF MUSEUM AND LIBRARY SERVICES § 1181.110 Self...

10 CFR 110.44 - Physical security standards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Physical security standards. 110.44 Section 110.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Review of License Applications § 110.44 Physical security standards. (a) Physical security measures in recipient...

45 CFR 159.110 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Definitions. 159.110 Section 159.110 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.110 Definitions. For purposes of part 159, the following definitions...

34 CFR 110.32 - Mediation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Mediation. 110.32 Section 110.32 Education Regulations..., Conciliation, and Enforcement Procedures § 110.32 Mediation. (a) ED promptly refers to the Federal Mediation and Conciliation Service or to the mediation agency designated by the Secretary of Health and Human...

46 CFR 110.30-1 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false General. 110.30-1 Section 110.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Testing and Inspection § 110.30-1 General. (a) This section supplements the general requirements for testing and inspecting...

46 CFR 110.01-1 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false General. 110.01-1 Section 110.01-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-1 General. (a) This subchapter applies to all electrical installations on vessels subject to...

46 CFR 110.01-1 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false General. 110.01-1 Section 110.01-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Applicability § 110.01-1 General. (a) This subchapter applies to all electrical installations on vessels subject to...

46 CFR 110.30-5 - Inspection for certification.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Inspection for certification. 110.30-5 Section 110.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Testing and Inspection § 110.30-5 Inspection for certification. Electric installations and electric...

46 CFR 110.30-1 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false General. 110.30-1 Section 110.30-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Testing and Inspection § 110.30-1 General. (a) This section supplements the general requirements for testing and inspecting...

46 CFR 110.30-5 - Inspection for certification.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Inspection for certification. 110.30-5 Section 110.30-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Testing and Inspection § 110.30-5 Inspection for certification. Electric installations and electric...

10 CFR 110.100 - Public hearings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Public hearings. 110.100 Section 110.100 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Hearings § 110.100 Public hearings. Hearings under this part will be public unless the Commission directs otherwise. ...

40 CFR 420.110 - Applicability; description of the alkaline cleaning subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... alkaline cleaning subcategory. 420.110 Section 420.110 Protection of Environment ENVIRONMENTAL PROTECTION... Alkaline Cleaning Subcategory § 420.110 Applicability; description of the alkaline cleaning subcategory... alkaline cleaning baths to remove mineral and animal fats or oils from the steel, and those rinsing...

40 CFR 420.110 - Applicability; description of the alkaline cleaning subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... alkaline cleaning subcategory. 420.110 Section 420.110 Protection of Environment ENVIRONMENTAL PROTECTION... Alkaline Cleaning Subcategory § 420.110 Applicability; description of the alkaline cleaning subcategory... alkaline cleaning baths to remove mineral and animal fats or oils from the steel, and those rinsing...

40 CFR 420.110 - Applicability; description of the alkaline cleaning subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... alkaline cleaning subcategory. 420.110 Section 420.110 Protection of Environment ENVIRONMENTAL PROTECTION... Alkaline Cleaning Subcategory § 420.110 Applicability; description of the alkaline cleaning subcategory... alkaline cleaning baths to remove mineral and animal fats or oils from the steel, and those rinsing...

40 CFR 420.110 - Applicability; description of the alkaline cleaning subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... alkaline cleaning subcategory. 420.110 Section 420.110 Protection of Environment ENVIRONMENTAL PROTECTION... Alkaline Cleaning Subcategory § 420.110 Applicability; description of the alkaline cleaning subcategory... alkaline cleaning baths to remove mineral and animal fats or oils from the steel, and those rinsing...

40 CFR 420.110 - Applicability; description of the alkaline cleaning subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... alkaline cleaning subcategory. 420.110 Section 420.110 Protection of Environment ENVIRONMENTAL PROTECTION... Alkaline Cleaning Subcategory § 420.110 Applicability; description of the alkaline cleaning subcategory... alkaline cleaning baths to remove mineral and animal fats or oils from the steel, and those rinsing...

24 CFR 87.110 - Certification and disclosure.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Certification and disclosure. 87.110 Section 87.110 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NEW RESTRICTIONS ON LOBBYING General § 87.110 Certification and disclosure. (a) Each...

38 CFR 4.110 - Ulcers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Ulcers. 4.110 Section 4.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings The Digestive System § 4.110 Ulcers. Experience has shown that the term “peptic...

38 CFR 4.110 - Ulcers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Ulcers. 4.110 Section 4.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings The Digestive System § 4.110 Ulcers. Experience has shown that the term “peptic...

38 CFR 4.110 - Ulcers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Ulcers. 4.110 Section 4.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings The Digestive System § 4.110 Ulcers. Experience has shown that the term “peptic...

38 CFR 4.110 - Ulcers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Ulcers. 4.110 Section 4.110 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS SCHEDULE FOR RATING DISABILITIES Disability Ratings The Digestive System § 4.110 Ulcers. Experience has shown that the term “peptic...

10 CFR 1041.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Self-evaluation. 1041.110 Section 1041.110 Energy... PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF ENERGY § 1041.110 Self-evaluation. (a) The agency... representing handicapped persons, to participate in the self-evaluation process by submitting comments (both...

45 CFR 1175.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Self-evaluation. 1175.110 Section 1175.110 Public... PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL ENDOWMENT FOR THE HUMANITIES § 1175.110 Self-evaluation... organizations representing handicapped persons, to participate in the self-evaluation process by submitting...

22 CFR 1005.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Self-evaluation. 1005.110 Section 1005.110... PROGRAMS OR ACTIVITIES CONDUCTED BY THE INTER-AMERICAN FOUNDATION § 1005.110 Self-evaluation. (a) The... representing handicapped persons, to participate in the self-evaluation process by submitting comments (both...

22 CFR 1005.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Self-evaluation. 1005.110 Section 1005.110 Foreign Relations INTER-AMERICAN FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE INTER-AMERICAN FOUNDATION § 1005.110 Self-evaluation. (a) The...

45 CFR 1158.110 - Certification and disclosure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Certification and disclosure. 1158.110 Section 1158.110 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS NEW RESTRICTIONS ON LOBBYING General § 1158.110...

42 CFR 110.33 - Death benefits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Death benefits. 110.33 Section 110.33 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Available Benefits § 110.33 Death benefits. (a) Eligible survivors may be able to receive...

42 CFR 110.73 - Approval of benefits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Approval of benefits. 110.73 Section 110.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.73 Approval of benefits. When the Secretary has...

42 CFR 110.73 - Approval of benefits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Approval of benefits. 110.73 Section 110.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.73 Approval of benefits. When the Secretary has...

42 CFR 110.73 - Approval of benefits.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Approval of benefits. 110.73 Section 110.73 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES VACCINES COUNTERMEASURES INJURY COMPENSATION PROGRAM Secretarial Determinations § 110.73 Approval of benefits. When the Secretary has...