114. ARAI Hot cell (ARA626) Building details of fuel storage ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

114. ARA-I Hot cell (ARA-626) Building details of fuel storage pit in plan and section. Spaces shown for 20 elements. Norman Engineering Company: 961-area/SF-626-S-4. Date: January 1959. Ineel index code no. 068-0626-60-613-102752. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

Development of a Plutonium Ceramic Target for the MASHA Separator

NASA Astrophysics Data System (ADS)

Shaughnessy, D. A.; Moody, K. J.; Kenneally, J. M.; Wild, J. F.; Stoyer, M. A.; Lougheed, R. W.; Yeremin, A. V.; Oganessian, Yu. Ts.

2004-04-01

We are participating in the development of the target for the MASHA (Mass Analyzer of Super Heavy Atoms) on-line mass separator in Dubna. Along with recent upgrades of the U400 cyclotron, MASHA will provide for at least a ten-fold increase in the production- and-detection rate for element 114 atoms, and will allow us to measure their atomic masses precisely. The MASHA separator will employ a thick Pu ceramic target capa- ble of tolerating temperatures in the vicinity of 2000 C without vaporizing the actinide compound. Reaction products will diffuse out of the target and will drift to an ECR ion source after which they will be transported through the separator and will impinge on a position-sensitive focal-plane detector array. Furthermore, operation of the MASHA hot target/ion source combination will provide chemical volatility information that will support our assignment of an atomic number of 114 to these nuclei. Taken together, these experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments in which the chemical properties of the heaviest elements are studied.

Periodic variation and its effect on management and prognosis of Korean patients with acute myocardial infarction.

PubMed

Park, Hyo Eun; Koo, Bon-Kwon; Lee, Wonjae; Cho, Youngjin; Park, Jin Sik; Choi, Ji-Yong; Jeong, Myung-Ho; Kim, Jong Hyun; Chae, Shung Chull; Kim, Young Jo; Nam, Chang-Wook; Lee, Jae-Hwan; Choi, Dong Hoon; Hong, Taek Jong; Chae, Jei Keon; Rhew, Jae Young; Kim, Kee Sik; Kim, Hyo-Soo; Oh, Byung-Hee; Park, Young Bae

2010-05-01

The characteristics of the periodic variation in acute myocardial infarction (AMI) and the subsequent effect on management and prognosis have not been fully investigated in a large number of Asian populations. From a prospective, observational multicenter online registry, 4,573 patients diagnosed as AMI in Korea from January to December 2006 were included. The highest incidence of AMI was between 8 a.m. and noon. The number of cases was highest in the winter and lowest in the autumn (13.6 vs 11.4 patients per day, P<0.001). Patients with symptom onset during working hours had a shorter time to first medical contact (203+/-288 min) compared with out-of-hours onset (230+/-288 min, P=0.003). In patients who underwent primary angioplasty, out-of hours symptom onset was associated with a greater time delay in both the patient's and the medical facility's response (door-to-balloon time out-of hours vs working hours: 101+/-54 min vs 84+/-44 min, P<0.001). In patients with ST-segment elevation myocardial infarction, symptoms to first medical contact showed a significant relationship to in-hospital mortality (for every 10 min of symptoms to first medical contact, odds ratio 1.006, 95% confidence interval 1.001-1.012, P=0.018) Circadian and periodic variation in AMI exists in Korean patients, which resulted in different patient behavior, hospital management and outcomes.

Field, coil, and echo-time influence on sensitivity and reproducibility of brain proton MR spectroscopy.

PubMed

Inglese, M; Spindler, M; Babb, J S; Sunenshine, P; Law, M; Gonen, O

2006-03-01

Clinical MR imaging scanners now offer many choices of hardware configurations that were not available in the first 25 years of their existence. Our goal was to assess the influence of coil technology, magnetic field strength, and echo time (TE) on the sensitivity, reflected by the signal intensity-to-noise-ratio (SNR) and reproducibility of proton MR spectroscopy (1H-MR spectroscopy). The SNR, the intersubject reproducibility, and the intrasubject reproducibility of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) levels were compared at the common TEs of 30, 144, and 288 ms, by using 1H-MR spectroscopy in 6 volunteers at (1) 3T with a single-element quadrature (SEQ); (2) 1.5T with SEQ; and (3) 1.5T with a 12-channel phased-array (PA) head coil. In terms of sensitivity, the best SNR for all metabolites was obtained at the shortest TE (30 ms). It was comparable between the 3 and 1.5T with the PA, but approximately 35% better than the 1.5T with SEQ. This SNR difference declined <25% at TE of 144 ms and to equity among all imagers at TE of 288 ms. Reproducibility, reflected in the coefficient of variation (CV), was best for NAA at TE of 288 ms, 15%-50% better than at TE of 30 ms in either gray (GM) or white matter (WM). The CV for Cr was best, at TE of 288 ms for GM, but its WM results were independent of TE. Metabolite level reproducibility did not depend on coil technology or magnetic field strength. For the same coil type, the SNR of all major metabolites was approximately 35% better at 3T than at 1.5T. This advantage, however, was offset at 1.5T with a PA coil, making it a cost-effective upgrade for existing scanners. Surprisingly and counterintuitively, despite the lowest SNR, the best reproducibility was obtained at the longest TE (288 ms), regardless of field or coil.

High copy number of highly similar mariner-like transposons in planarian (Platyhelminthe): evidence for a trans-phyla horizontal transfer.

PubMed

Garcia-Fernàndez, J; Bayascas-Ramírez, J R; Marfany, G; Muñoz-Mármol, A M; Casali, A; Baguñà, J; Saló, E

1995-05-01

Several DNA sequences similar to the mariner element were isolated and characterized in the platyhelminthe Dugesia (Girardia) tigrina. They were 1,288 bp long, flanked by two 32 bp-inverted repeats, and contained a single 339 amino acid open-reading frame (ORF) encoding the transposase. The number of copies of this element is approximately 8,000 per haploid genome, constituting a member of the middle-repetitive DNA of Dugesia tigrina. Sequence analysis of several elements showed a high percentage of conservation between the different copies. Most of them presented an intact ORF and the standard signals of actively expressed genes, which suggests that some of them are or have recently been functional transposons. The high degree of similarity shared with other mariner elements from some arthropods, together with the fact that this element is undetectable in other planarian species, strongly suggests a case of horizontal transfer between these two distant phyla.

Archaeological Investigations at Sites 45-OK-287 and 45-OK-288, Chief Joseph Dam Project, Washington.

DTIC Science & Technology

1984-01-01

marks and evidence of burning by element ........ ........................ . 258 xviii .. . - ... ., ." xvii LIST OF PLATES Plate 1-1. 45-OK-287: view...which the site is located, and glaclotacustrlne sediments of two ages exposed In the opposite bank. The lowest major terrace the river cut In the...the site were exposed in fewer excavation units, but they have a finer grain size and greater proportion of angular cobbles, deriving from the bedrock

The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers.

PubMed

Othman, Ahmed A; Haig, George; Florian, Hana; Locke, Charles; Gertsik, Lev; Dutta, Sandeep

2014-06-01

ABT-288 is a potent and selective H3 receptor antagonist with procognitive effects in several preclinical models. In previous studies, 3 mg once daily was the maximal tolerated dose in healthy volunteers. This study characterized the safety, tolerability and pharmacokinetics of ABT-288 in stable subjects with schizophrenia. This was a randomized, double-blind, placebo-controlled, dose-escalating study of ABT-288 (10 dose levels, from 1 to 60 mg once daily for 14 days) in stable subjects with schizophrenia treated with an atypical antipsychotic. In each dose group, five to seven and two to three participants were assigned to ABT-288 and placebo, respectively. Of the 67 participants enrolled, nine participants (on ABT-288) were prematurely discontinued, in seven of these due to adverse events. ABT-288 was generally safe and tolerated at doses up to 45 mg once daily. The most common adverse events, in decreasing frequency (from 31 to 5%), were abnormal dreams, headache, insomnia, dizziness, somnolence, dysgeusia, dry mouth, psychotic disorder, parosmia and tachycardia. Adverse events causing early termination were psychotic events (four) and increased creatine phosphokinase, pyrexia and insomnia (one each). The half-life of ABT-288 ranged from 28 to 51 h, and steady state was achieved by day 12 of dosing. At comparable multiple doses, ABT-288 exposure in subjects with schizophrenia was 45% lower than that previously observed in healthy subjects. At trough, ABT-288 cerebrospinal fluid concentrations were 40% of the total plasma concentrations. ABT-288 was tolerated at a 15-fold higher dose and 12-fold higher exposures in subjects with schizophrenia than previously observed in healthy volunteers. The greater ABT-288 tolerability was not due to limited brain uptake. © 2013 The British Pharmacological Society.

New Fragment Separation Technology for Superheavy Element Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaughnessy, D A; Moody, K J; Henderson, R A

2008-01-28

This project consisted of three major research areas: (1) development of a solid Pu ceramic target for the MASHA separator, (2) chemical separation of nuclear decay products, and (3) production of new isotopes and elements through nuclear reactions. There have been 16 publications as a result of this project, and this collection of papers summarizes our accomplishments in each of the three areas of research listed above. The MASHA (Mass Analyzer for Super-Heavy Atoms) separator is being constructed at the U400 Cyclotron at the Flerov Laboratory of Nuclear Reactions in Dubna, Russia. The purpose of the separator is to physicallymore » separate the products from nuclear reactions based on their isotopic masses rather than their decay characteristics. The separator was designed to have a separation between isotopic masses of {+-}0.25 amu, which would enable the mass of element 114 isotopes to be measured with outstanding resolution, thereby confirming their discovery. In order to increase the production rate of element 114 nuclides produced via the {sup 244}Pu+{sup 48}Ca reaction, a new target technology was required. Instead of a traditional thin actinide target, the MASHA separator required a thick, ceramic-based Pu target that was thick enough to increase element 114 production while still being porous enough to allow reaction products to migrate out of the target and travel through the separator to the detector array located at the back end. In collaboration with UNLV, we began work on development of the Pu target for MASHA. Using waste-form synthesis technology, we began by creating zirconia-based matrices that would form a ceramic with plutonium oxide. We used samarium oxide as a surrogate for Pu and created ceramics that had varying amounts of the starting materials in order to establish trends in material density and porosity. The results from this work are described in more detail in Refs. [1,4,10]. Unfortunately, work on MASHA was delayed in Russia because it was found that the efficiency of transporting products from the target chamber to the detector array was much too low for applications in heavy element experiments where production rates are on the order of one atom per day or less. Work continues on the MASHA separator, and once the efficiency has been improved, we plan to continue our work on the Pu target for future element 114 experiments. Due to the delays of the MASHA separator, work on establishing the identity of heavy element species produced through nuclear reactions focused instead on chemical separations. In particular, element 115 decays through a series of alpha decays, terminating with an element 105 isotope with a long half-life ({approx} 1 day). By chemically separating the element 105 daughter and observing its subsequent fission decay, the identity of the original parent nucleus can be established through the genetic correlation of the initial series of alpha decays. Chemical separations of element 105 were developed in Switzerland, Russia, and at LLNL. Over the course of two experiments, reaction products from the {sup 243}Am+{sup 48}Ca reaction were collected in a copper block and subsequently processed for chemical separation of the Group Five elements [8,9,13,15]. The Group Five elements were initially separated from the Group Four species, and then the samples were sub-divided into tantalum and niobium fractions. All of the fission events were observed in the tantalum fractions, which implied that element 105 behaved more like tantalum under the chemical conditions of these experiments. These experiments were very successful, and not only demonstrated that chemical separation could be performed on single atoms of interest, but also lent proof to the identity of the parent nucleus as element 115. Subsequent analysis of the alpha spectra taken during the experiment further prove that the fission events observed during the two experiments came from element 105 as the decay daughter of element 115 and could not attributed to interference from other background species [16]. The final aspect of this project was the production of new isotopes and elements. All of the experiments were performed in Dubna at the U400 Cyclotron and the results are described in more detail in Refs. [2,3,5-8,11,12,14]. The first experiments were designed to establish the decay properties of isotopes of elements 112, 114, and 116 [5]. Because these isotopic signatures were established through these initial experiments, the discovery of element 118 [11] was possible, since the 118 nuclides decayed into these previously studied isotopes. This was the first successful report of the discovery of element 118, which was reported by the media to a large extent. The last experiment that was performed for this project was the production and detection of a new isotope of element 113 [14].« less

46 CFR 502.288 - Reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 9 2013-10-01 2013-10-01 false Reports. 502.288 Section 502.288 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Nonadjudicatory Investigations § 502.288 Reports. The Commission may issue an order requiring a person to file a report or...

46 CFR 502.288 - Reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 9 2011-10-01 2011-10-01 false Reports. 502.288 Section 502.288 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Nonadjudicatory Investigations § 502.288 Reports. The Commission may issue an order requiring a person to file a report or...

46 CFR 502.288 - Reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 9 2014-10-01 2014-10-01 false Reports. 502.288 Section 502.288 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Nonadjudicatory Investigations § 502.288 Reports. The Commission may issue an order requiring a person to file a report or...

46 CFR 502.288 - Reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 9 2012-10-01 2012-10-01 false Reports. 502.288 Section 502.288 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Nonadjudicatory Investigations § 502.288 Reports. The Commission may issue an order requiring a person to file a report or...

46 CFR 502.288 - Reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Reports. 502.288 Section 502.288 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Nonadjudicatory Investigations § 502.288 Reports. The Commission may issue an order requiring a person to file a report or...

42 CFR 137.288 - What is the National Historic Preservation Act (NHPA)?

Code of Federal Regulations, 2010 CFR

2010-10-01

... (NHPA)? 137.288 Section 137.288 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Nepa Process § 137.288 What is the National Historic Preservation Act (NHPA)? The NHPA requires Federal...

Theoretical Predictions of Cross-Sections of the Super-Heavy Elements

NASA Astrophysics Data System (ADS)

Bouriquet, B.; Kosenko, G.; Abe, Y.

The evaluation of the residue cross-sections of reactionssynthesising superheavy elements has been achieved by the combination of the two-step model for fusion and the evaporation code (KEWPIE) for survival probability. The theoretical scheme of those calculations is presented, and some encouraging results are given, together with some difficulties. With this approach, the measured excitation functions of the 1n reactions producing elements with Z=108, 110, 111 and 112 are well reproduced. Thus, the model has been used to predict the cross-sections of the reactions leading to the formation of the elements with Z=113 and Z=114.

MCT Detectors and ROICS for Various Format MWIR and LWIR Arrays

DTIC Science & Technology

2009-10-01

ABSTRACT Silicon ROICs for MCT LWIR (4x288, 6x576) and MWIR (128x128) diode matrix arrays were designed, manufactured and tested. MCT layers...of polysilicon and two metallization levels. MCT Detectors and ROICs for Various Format MWIR and LWIR Arrays RTO-MP-SET-151 7 - 1...Format MWIR and LWIR Arrays 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f

Archaeological Investigations at Sites 45-OK-287 and 45-OK-288, Chief Joseph Dam Project, Washington.

DTIC Science & Technology

1984-01-01

Table C-1. Distribution of butchering marks and evidence of burning by element .. ....... ....... ....... .. 258 xvii9. LIST OF PLATES Plate 1-1. 45-OK...the vicinity of the Omak Trench. Till forms the terrace on which the site Is located, and glaclolacustrIne sediments of two ! -ages exposed In the...the site were exposed In fewer excavation units, but they have a finer grain size and greater proportion of angular cobbles, deriving from the bedrock

Proceedings of the 2010 Antenna Applications Symposium Held in Monticello, Illinois on 21-23 September 2010. Volume 2

DTIC Science & Technology

2010-12-01

papers relating to antenna arrays and elements, millimeter wave antennas, simulation and measurement of antennas, integrated antennas, and antenna...Hansen 282 v Artificial Impedance Surface Antenna Design and Simulation D.J. Gregoire and J.S. Colburn 288 uCAST - A New Generation UTD...radiating mode to be self-resonant in the electrically small region. 260 hs (cm) Predicted L0 (nH) Simulated L0 (nH) R1 (Ω) Q1 -- -- -- 7.5

High-performance IR detectors at SCD present and future

NASA Astrophysics Data System (ADS)

Nesher, O.; Klipstein, P. C.

2005-09-01

For over 27 years, SCD has been manufacturing and developing a wide range of high performance infra-red detectors, designed to operate in either the mid-wave (MWIR) or the long-wave (LWIR) atmospheric windows. These detectors have been integrated successfully into many different types of system including missile seekers, Time Delay Integration scanning systems, Hand-Held cameras, Missile Warning Systems and many others. SCD's technology for the MWIR wavelength range is based on its well established 2-D arrays of InSb photodiodes. The arrays are flip-chip bonded to SCD's analogue or digital signal processors, all of which have been designed in-house. The 2-D Focal Plane Array (FPA) detectors have a format of 320×256 elements for a 30 μm pitch and 480×384 or 640×512 elements for a 20 μm pitch. Typical operating temperatures are around 77-85K. Five years ago SCD began to develop a new generation of MWIR detectors based on the epitaxial growth of Antimonide Based Compound Semiconductors (ABCS). This ABCS technology allows band-gap engineering of the detection material which enables higher operating temperatures and multi-spectral detection. This year SCD presented its first prototype FPA from this program, an InAlSb based detector operating at a temperature of 100 K. By the end of this year SCD will introduce the first prototype MWIR detector with a 640×512 element format and a pitch of 15 μm. For the LWIR wave-length range SCD manufactures both linear Hg1-xCdxTe (MCT) detectors with a line of 250 elements and Time Delay and Integration (TDI) detectors with formats of 288×4 and 480×6. Recently, SCD has demonstrated its first prototype un-cooled detector which is based on VOx technology and which has a format of 384×288 elements, a pitch of 25 μm and a typical NETD of 50mK at F/1. In this paper we describe the present technologies and products of SCD and the future evolution of our detectors for the MWIR and LWIR detection.

High-performance IR detectors at SCD present and future

NASA Astrophysics Data System (ADS)

Nesher, O.; Klipstein, P. C.

2006-03-01

For over 27 years, SCD has been manufacturing and developing a wide range of high performance infrared detectors, designed to operate in either the mid-wave (MWIR) or the long-wave (LWIR) atmospheric windows. These detectors have been integrated successfully into many different types of system including missile seekers, time delay integration scanning systems, hand-held cameras, missile warning systems and many others. SCD's technology for the MWIR wavelength range is based on its well established 2D arrays of InSb photodiodes. The arrays are flip-chip bonded to SCD's analogue or digital signal processors, all of which have been designed in-house. The 2D focal plane array (FPA) detectors have a format of 320×256 elements for a 30-μm pitch and 480×384 or 640×512 elements for a 20-μm pitch. Typical operating temperatures are around 77-85 K. Five years ago SCD began to develop a new generation of MWIR detectors based on the epitaxial growth of antimonide based compound semiconductors (ABCS). This ABCS technology allows band-gap engineering of the detection material which enables higher operating temperatures and multi-spectral detection. This year SCD presented its first prototype FPA from this program, an InAlSb based detector operating at a temperature of 100 K. By the end of this year SCD will introduce the first prototype MWIR detector with a 640×512 element format and a pitch of 15 μm. For the LWIR wavelength range SCD manufactures both linear Hg1-xCdxTe (MCT) detectors with a line of 250 elements and time delay and integration (TDI) detectors with formats of 288×4 and 480×6. Recently, SCD has demonstrated its first prototype uncooled detector which is based on VOx technology and which has a format of 384×288 elements, a pitch of 25 μm, and a typical NETD of 50 mK at F/1. In this paper, we describe the present technologies and products of SCD and the future evolution of our detectors for the MWIR and LWIR detection.

77 FR 9841 - Modification of Area Navigation Route T-288; WY

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-21

...-1193; Airspace Docket No. 11-ANM-14] Modification of Area Navigation Route T-288; WY AGENCY: Federal...) route T-288 by extending the route westward from the Rapid City, SD, VORTAC to the Gillette, WY, VOR/DME... published in the Federal Register a notice of proposed rulemaking (NPRM) to modify RNAV route T-288 by...

ANALYSIS OF SURGICAL SITE INFECTIONS IN PEDIATRIC PATIENTS AFTER ORTHOPEDIC SURGERY: A CASE-CONTROL STUDY

PubMed Central

Chagas, Mariana de Queiroz Leite; Costa, Ana Maria Magalhães; Mendes, Pedro Henrique Barros; Gomes, Saint Clair

2017-01-01

ABSTRACT Objectives: To describe the rate of surgical site infections in children undergoing orthopedic surgery in centers of excellence and analyze the patients’ profiles. Methods: Medical records of pediatric patients undergoing orthopedic surgery in the Jamil Haddad National Institute of Traumatology and Orthopedics from January 2012 to December 2013 were analyzed and monitored for one year. Patients diagnosed with surgical site infection were matched with patients without infection by age, date of admission, field of orthopedic surgery and type of surgical procedure. Patient, surgical and follow-up variables were examined. Descriptive, bivariate and correspondence analyses were performed to evaluate the patients’ profiles. Results: 347 surgeries and 10 surgical site infections (2.88%) were identified. There was association of infections with age - odds ratio (OR) 11.5 (confidence interval - 95%CI 1.41-94.9) -, implant - OR 7.3 (95%CI 1.46-36.3) -, preoperative period - OR 9.8 (95%CI 1.83-53.0), and length of hospitalization - OR 20.6 (95%CI 3.7-114.2). The correspondence analysis correlated the infection and preoperative period, weight, weight Z-score, age, implant, type of surgical procedure, and length of hospitalization. Average time to diagnosis of infection occurred 26.5±111.46 days after surgery. Conclusions: The rate of surgical site infection was 2.88%, while higher in children over 24 months of age who underwent surgical implant procedures and had longer preoperative periods and lengths of hospitalization. This study identified variables for the epidemiological surveillance of these events in children. Available databases and appropriate analysis methods are essential to monitor and improve the quality of care offered to the pediatric population. PMID:28977312

Mercury and neuromotor function among children in a rural town in Chile

PubMed Central

Huber, Stella Maria; Schomaker, Michael; Heumann, Christian; Schierl, Rudolf; Michalke, Bernhard; Jenni, Oskar G.; Caflisch, Jon; Muñoz, Daniel Moraga; von Ehrenstein, Ondine S.; Radon, Katja

2016-01-01

Background Mercury (Hg) exposure from artisanal gold mining has adverse effects on the neuromotor function in adults. However, few studies have examined this relationship in children. Objectives To investigate the impact of Hg exposure on children’s neuromotor function. Methods Cross-sectional data on Hg risk factors and demographics were collected from n = 288 children (response = 68.9%). Based on complete cases (CCs) (n = 130) and multiple imputations (n = 288), associations between fingernail Hg and four different neuromotor function components were calculated using multiple logistic regression adjusted for confounders. Results Of the children, 11.1, 14.9, 63.9, and 10.4% had pathologic pure motor skills, adaptive fine motor skills, adaptive gross motor skills, and static balance, respectively. No significant association between fingernail Hg and any neuromotor component was found. However, Hg burning in the household was significantly associated with children’s pathologic pure motor skills (OR 3.07 95% CI 1.03–9.18). Conclusion Elemental Hg exposure in the household might have adverse long-term effects on children’s pure motor skills. PMID:27078174

Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers

PubMed Central

Othman, Ahmed A; Haig, George; Florian, Hana; Locke, Charles; Zhang, Jun; Dutta, Sandeep

2013-01-01

Aim The objective of this work was to characterize the safety, tolerability and pharmacokinetics of ABT-288, a highly selective histamine H3 receptor antagonist, in healthy young adults and elderly subjects following single and multiple dosing in a phase 1 setting. Methods Single doses (0.1, 0.3, 1, 3, 10, 20 and 40 mg ABT-288) and multiple doses (0.5, 1.5, 3 and 6 mg ABT-288 once-daily for 14 days) were evaluated in young adults and multiple doses (0.5, 1.5, 3 and 5 mg ABT-288 once-daily for 12 days) were evaluated in elderly subjects using randomized, double-blind, placebo-controlled, dose-escalating study designs. The effect of food on ABT-288 pharmacokinetics (5 mg single dose) was evaluated using an open label, randomized, crossover design. Results ABT-288 safety, tolerability and pharmacokinetics were comparable in young and elderly subjects. Single doses up to 40 mg and multiple doses up to 3 mg once-daily were generally safe and well tolerated. The most frequently reported adverse events were hot flush, headache, abnormal dreams, insomnia, nausea and dizziness. ABT-288 exposure (AUC) was dose-proportional over the evaluated dose ranges. The mean elimination half-life ranged from 40 to 61 h across dose groups. Steady state was achieved by day 10 of once-daily dosing with 3.4- to 4.2-fold accumulation. Food did not have a clinically meaningful effect on ABT-288 exposure. Conclusions Based on the above results, 1 and 3 mg once-daily doses of ABT-288 were advanced to phase 2 evaluation in Alzheimer's patients. PMID:23016924

Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers.

PubMed

Othman, Ahmed A; Haig, George; Florian, Hana; Locke, Charles; Zhang, Jun; Dutta, Sandeep

2013-05-01

The objective of this work was to characterize the safety, tolerability and pharmacokinetics of ABT-288, a highly selective histamine H3 receptor antagonist, in healthy young adults and elderly subjects following single and multiple dosing in a phase 1 setting. Single doses (0.1, 0.3, 1, 3, 10, 20 and 40 mg ABT-288) and multiple doses (0.5, 1.5, 3 and 6 mg ABT-288 once-daily for 14 days) were evaluated in young adults and multiple doses (0.5, 1.5, 3 and 5 mg ABT-288 once-daily for 12 days) were evaluated in elderly subjects using randomized, double-blind, placebo-controlled, dose-escalating study designs. The effect of food on ABT-288 pharmacokinetics (5 mg single dose) was evaluated using an open label, randomized, crossover design. ABT-288 safety, tolerability and pharmacokinetics were comparable in young and elderly subjects. Single doses up to 40 mg and multiple doses up to 3 mg once-daily were generally safe and well tolerated. The most frequently reported adverse events were hot flush, headache, abnormal dreams, insomnia, nausea and dizziness. ABT-288 exposure (AUC) was dose-proportional over the evaluated dose ranges. The mean elimination half-life ranged from 40 to 61 h across dose groups. Steady state was achieved by day 10 of once-daily dosing with 3.4- to 4.2-fold accumulation. Food did not have a clinically meaningful effect on ABT-288 exposure. Based on the above results, 1 and 3 mg once-daily doses of ABT-288 were advanced to phase 2 evaluation in Alzheimer's patients. © 2012 Abbott Laboratories. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.

Clinicians' adherence to international guidelines in the clinical care of adults with inflammatory bowel disease.

PubMed

Jackson, Belinda D; Con, Danny; Liew, Danny; De Cruz, Peter

2017-05-01

Although evidence-based guidelines have been developed for inflammatory bowel disease (IBD), the extent to which they are followed is unclear. The objective of this study was to review clinicians' adherence to international IBD guidelines. Retrospective data collection of patients attending a tertiary Australian hospital IBD clinic over a 12-month period. Management practices were audited and compared to ECCO (European Crohn's and Colitis Organization) guidelines. Data from 288 patients were collected: 47% (136/288) male; mean age 43; 140/288 (49%) patients had ulcerative colitis (UC); 145/288 (50%) patients had Crohn's disease (CD); 3/288 (1%) patients had IBD-unclassified (IBD-U). Patient care was undertaken by gastroenterologists, trainees and general practitioners. Overall adherence to disease management guidelines occurred in 204/288 (71%) of patient encounters. Discrepancies between guidelines and management were found in: 25/80 (31%) of patients with UC in remission receiving oral 5-aminosalicyclates (5-ASAs) as maintenance therapy, and; 46/110 (42%) of patients with small bowel and/or ileo-cecal CD receiving 5-ASA. Preventive Care: Adherence to ≥1 additional component of preventive care was observed in 73/288 (25%) of patient encounters: 12/133 (9%) on thiopurines underwent annual skin checks; 61/288 (21%) of patients with IBD underwent a bone scan; 46/288 (16%) patients were reminded to have their influenza vaccine. Psychological care: Assessment of psychological wellbeing was undertaken in only 16/288 (6%) of patients. There remains a gap between adherence to international guidelines and clinical practice. Standardizing practice using evidence-based clinical pathways may be a strategy towards improving the quality of IBD outpatient management.

Chemical experiments with superheavy elements.

PubMed

Türler, Andreas

2010-01-01

Unnoticed by many chemists, the Periodic Table of the Elements has been extended significantly in the last couple of years and the 7th period has very recently been completed with eka-Rn (element 118) currently being the heaviest element whose synthesis has been reported. These 'superheavy' elements (also called transactinides with atomic number > or = 104 (Rf)) have been artificially synthesized in fusion reactions at accelerators in minute quantities of a few single atoms. In addition, all isotopes of the transactinide elements are radioactive and decay with rather short half-lives. Nevertheless, it has been possible in some cases to investigate experimentally chemical properties of transactinide elements and even synthesize simple compounds. The experimental investigation of superheavy elements is especially intriguing, since theoretical calculations predict significant deviations from periodic trends due to the influence of strong relativistic effects. In this contribution first experiments with hassium (Hs, atomic number 108), copernicium (Cn, atomic number 112) and element 114 (eka-Pb) are reviewed.

Measurement of the transverse four-dimensional beam rms-emittance of an intense uranium beam at 11.4 MeV/u

NASA Astrophysics Data System (ADS)

Xiao, C.; Groening, L.; Gerhard, P.; Maier, M.; Mickat, S.; Vormann, H.

2016-06-01

Knowledge of the transverse four-dimensional beam rms-parameters is essential for applications that involve lattice elements that couple the two transverse degrees of freedom (planes). Usually pepper-pots are used for measuring these beam parameters. However, for ions their application is limited to energies below 150 keV/u. This contribution is on measurements of the full transverse four-dimensional second-moments beam matrix of high intensity uranium ions at an energy of 11.4 MeV/u. The combination of skew quadrupoles with a slit/grid emittance measurement device has been successfully applied.

Studies of Flerovium and Element 115 Homologs with Macrocyclic Extractants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Despotopulos, John D.

2015-03-12

Study of the chemistry of the heaviest elements, Z ≥ 104, poses a unique challenge due to their low production cross-sections and short half-lives. Chemistry also must be studied on the one-atom-at-a-time scale, requiring automated, fast, and very efficient chemical schemes. Recent studies of the chemical behavior of copernicium (Cn, element 112) and flerovium (Fl, element 114) together with the discovery of isotopes of these elements with half-lives suitable for chemical studies have spurred a renewed interest in the development of rapid systems designed to study the chemical properties of elements with Z ≥ 114. This dissertation explores both extractionmore » chromatography and solvent extraction as methods for development of a rapid chemical separation scheme for the homologs of flerovium (Pb, Sn, Hg) and element 115 (Bi, Sb), with the goal of developing a chemical scheme that, in the future, can be applied to on-line chemistry of both Fl and element 115. Carrier-free radionuclides, used in these studies, of the homologs of Fl and element 115 were obtained by proton activation of high-purity metal foils at the Lawrence Livermore National Laboratory (LLNL) Center for Accelerator Mass Spectrometry (CAMS): natIn(p,n) 113Sn, natSn(p,n) 124Sb, and Au(p,n) 197m,gHg. The carrier-free activity was separated from the foils by novel separation schemes based on ion exchange and extraction chromatography techniques. Carrier-free Pb and Bi isotopes were obtained from development of a novel generator based on cation exchange chromatography using the 232U parent to generate 212Pb and 212Bi. Macrocyclic extractants, specifically crown ethers and their derivatives, were chosen for these studies; crown ethers show high selectivity for metal ions. Finally. a potential chemical system for Fl was established based on the Eichrom Pb resin, and insight to an improved system based on thiacrown ethers is presented.« less

4 CFR 28.8 - Informal procedural advice.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Informal procedural advice. 28.8 Section 28.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL APPEALS BOARD; PROCEDURES APPLICABLE TO CLAIMS CONCERNING EMPLOYMENT PRACTICES AT THE GOVERNMENT ACCOUNTABILITY OFFICE...

Comparison of oral montelukast with oral zileuton in acute asthma: A randomized, double-blind, placebo-controlled study

PubMed Central

Magazine, Rahul; Shahul, Hameed Aboobackar; Chogtu, Bharti; Kamath, Asha

2016-01-01

Background: Leukotriene modifiers have an established role in the management of chronic asthma but their role in acute asthma is still under evaluation. Objective: To study and compare the effects of oral montelukast with oral zileuton in acute asthma. Materials and Methods: This study included 120 asthmatics and was conducted from September 2012 to March 2014. Patients were randomized into three different groups to receive montelukast or zileuton or placebo in addition to standard treatment for asthma exacerbation. Peak expiratory flow rate (PEFR) values, details of rescue medication and vital signs were recorded at 6 h, 12 h, 24 h, and 48 h of drug or placebo administration and at discharge. Additional recording was done in the morning (8–10 am) following admission. The primary endpoint was the mean PEFR of each group at these time points; the secondary end point being the need for rescue medications. Results: The mean PEFR recordings of the three study groups – placebo, montelukast, and zileuton – respectively, at various time points were as follows: at 6 h (223.25 ± 90.40, 199.00 ± 82.52, 233.75 ± 84.05; P = 0.240); at 12 h (271.00 ± 109.38, 251.50 ± 101.44, 309.50 ± 129.63; P = 0.048); at 24 h (288.25 ± 114.26, 269.00 ± 107.51, 324.50 ± 127.88; P = 0.080); and at 48 h (295.00 ± 114.80, 293.50 ± 113.24, 344.75 ± 119.91; P = 0.015); discharge (305.00 ± 118.56, 305.25 ± 119.51, 361.25 ± 119.70; P = 0.010). The mean PEFR for the three study groups at 8–10 am on the morning following admission was 268.75 ± 111.43, 252.50 ± 99.99, 306.75 ± 114.44; P = 0.047. Total rescue doses needed were 10, 1, and 0, respectively (P = 0.049). Conclusion: Zileuton is better than montelukast as an additional drug in acute asthma and results in significant improvement in lung function, and reduction in the need for rescue medications. PMID:27185992

Positron Annihilation Spectroscopy and Small Angle Neutron Scattering Characterization of Nanostructural Features in Irradiated Fe-Cu-Mn Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wirth, B D; Asoka-Kumar, P; Howell, R H

2001-01-01

Radiation embrittlement of nuclear reactor pressure vessel steels results from a high number density of nanometer sized Cu-Mn-Ni rich precipitates (CRPs) and sub-nanometer matrix features, thought to be vacancy-solute cluster complexes (VSC). However, questions exist regarding both the composition of the precipitates and the defect character and composition of the matrix features. We present results of positron annihilation spectroscopy (PAS) and small angle neutron scattering (SANS) characterization of irradiated and thermally aged Fe-Cu and Fe-Cu-Mn alloys. These complementary techniques provide insight into the composition and character of both types of nanoscale features. The SANS measurements indicate populations of CRPs andmore » VSCs in both alloys. The CRPs are coarser in the Fe-Cu alloy and the number densities of CRP and VSC increase with the addition of Mn. The PAS involved measuring both the positron lifetimes and the Doppler broadened annihilation spectra in the high momentum region to provide elemental sensitivity at the annihilation site. The spectra in Fe-Cu-Mn specimens thermally aged to peak hardness at 450 C and irradiated at 288 C are nearly identical to elemental Cu. Positron lifetime and spectrum measurements in Fe-Cu specimens irradiated at 288 C clearly show the existence of long lifetime ({approx}500 ps) open volume defects, which also contain Cu. Thus the SANS and PAS provide a self-consistent picture of nanostructures composed of CRPs and VSCs and tend to discount high Fe concentrations in the CRPs.« less

7 CFR 28.8 - Classification of cotton; determination.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

7 CFR 28.8 - Classification of cotton; determination.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

7 CFR 28.8 - Classification of cotton; determination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

7 CFR 28.8 - Classification of cotton; determination.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 2 2012-01-01 2012-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

7 CFR 28.8 - Classification of cotton; determination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Classification of cotton; determination. 28.8 Section... CONTAINER REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act Administrative and General § 28.8 Classification of cotton; determination. For the purposes of...

Implementation and Evaluation of a Recurring Interdisciplinary Community Health Fair in a Remote U.S.-Mexico Border Community.

PubMed

Lee, July; McKennett, Marianne; Rodriguez, Xavier; Smith, Sunny

2018-03-06

The purpose of this project was to design, implement, and assess a recurring interdisciplinary community health fair in an underserved border town. University of California San Diego (UCSD) medical and pharmacy students, under faculty supervision, worked alongside community partners in Calexico, California to implement a health fair two miles from the U.S.-Mexico border. Demographic and screening data were described from 293 participants from 2014 to 2016. Over 90% (269/293) listed Mexico as their country of birth, 82.9% (243/293) were monolingual Spanish speakers, 75.4% (221/293) had an annual household income of ≤ $20,000, and 58.7% (172/293) described their health as fair or poor. Screening revealed 91.1% (265/291) were overweight or obese, 37.8% (109/288) had hypertension, 9.3% (27/289) had elevated blood sugar, and 11.4% (33/289) had elevated total cholesterol levels. This model could be replicated in other training settings to increase exposure to border health issues and connect patients to local health services.

The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation.

PubMed

Gupta, P; Brown, D; Butler, P; Ellis, P; Grayson, K L; Land, G C; Macor, J E; Robson, S F; Wythes, M J; Shepperson, N B

1995-11-01

1. The aim of the present study was to investigate the in vivo pharmacological profile of CP-122,288, an indole-derivative with a conformationally restricted N-methylpyrrolidinyl basic side chain in the C-3 position. This C-3 substituent structurally differentiates CP-122,288 from the 5-HT1D receptor agonist sumatriptan, which possesses an N,N-dimethylaminoethyl group. [Formula: see text] 2. When administered prior to electrical stimulation of the trigeminal ganglion, CP-122,288 (0.3-300 ng kg-1, i.v.) produced a dose-related inhibition of plasma protein extravasation in rat dura mater (minimum effective dose, MED, 3 ng kg-1 i.v., P < 0.05; maximal inhibition of plasma extravasation at 30 ng kg-1 i.v., P < 0.01). Sumatriptan produced a similar inhibition of plasma leakage in the dura, but at much higher dose levels (MED, 100 micrograms kg-1 i.v., P < 0.05). Thus, CP-122,288 is of the order of 10(4) fold more potent than sumatriptan. 3. At all doses tested, CP-122,288 did not inhibit plasma protein extravasation measured in extracranial tissues such as the lower lip, eyelid, and conjunctiva. 4. In a separate series of studies in the anaesthetized rat, CP-122,288 (0.003-3 micrograms kg-1 i.v.) produced no change in either heart rate or mean arterial blood pressure, thus demonstrating that doses of CP-122,288 which inhibit plasma protein leakage in rat dura, are devoid of hemodynamic effects. 5. Following a 5 min period of electrical stimulation of the trigeminal ganglion, a 20 min period of sustained neurogenically-driven plasma extravasation, occurring in the absence of electrical stimulation, was initiated. By administration of the compound 5 min after completing the phase of electrical stimulation, this protocol permitted the evaluation of the activity of CP-122,288 on an ongoing and established inflammatory event. CP-122,288 (30 and 300 ng kg-1, i.v., P < 0.01 and P < 0.05, respectively) produced a complete inhibition of plasma protein leakage which was consistent with its effects when administered prior to trigeminal ganglion stimulation. 6. In the anaesthetized dog, CP-122,288 and sumatriptan, at 1-300 micrograms kg-1, i.v., produced a dose-dependent reduction in carotid arterial blood flow and coronary arterial diameter. These data demonstrate that sumatriptan inhibits neurogenic inflammation in the rat (MED, 100 micrograms kg-1, i.v.), and produces vasoconstriction in the dog, over a similar dose-range. Interestingly, doses of CP-122,288 that inhibit neurogenic inflammation in rat dura mater (0.3-300 ng kg-1) were demonstrated to be devoid of vasoconstrictor activity in either the carotid or coronary vascular beds of dog. 7. These data demonstrate that in the rat, CP-122,288 is a highly potent and selective inhibitor of neurogenic inflammation in intracranial tissues, at doses which are devoid of vasoconstrictor activity in dog. Potentially, CP-122,288 may be of use for the acute treatment of migraine, without the risk of cardiovascular side-effects.

Increased Risk of Interstitial Lung Disease in Children with a Single R288K Variant of ABCA3

PubMed Central

Wittmann, Thomas; Frixel, Sabrina; Höppner, Stefanie; Schindlbeck, Ulrike; Schams, Andrea; Kappler, Matthias; Hegermann, Jan; Wrede, Christoph; Liebisch, Gerhard; Vierzig, Anne; Zacharasiewicz, Angela; Kopp, Matthias Volkmar; Poets, Christian F; Baden, Winfried; Hartl, Dominik; van Kaam, Anton H; Lohse, Peter; Aslanidis, Charalampos; Zarbock, Ralf; Griese, Matthias

2016-01-01

The ABCA3 gene encodes a lipid transporter in type II pneumocytes critical for survival and normal respiratory function. The frequent ABCA3 variant R288K increases the risk for neonatal respiratory distress syndrome among term and late preterm neonates, but its role in children’s interstitial lung disease has not been studied in detail. In a retrospective cohort study of 228 children with interstitial lung disease related to the alveolar surfactant system, the frequency of R288K was assessed and the phenotype of patients carrying a single R288K variant further characterized by clinical course, lung histology, computed tomography and bronchoalveolar lavage phosphatidylcholine PC 32:0. Cell lines stably transfected with ABCA3-R288K were analyzed for intracellular transcription, processing and targeting of the protein. ABCA3 function was assessed by detoxification assay of doxorubicin, and the induction and volume of lamellar bodies. We found nine children with interstitial lung disease carrying a heterozygous R288K variant, a frequency significantly higher than in the general Caucasian population. All identified patients had neonatal respiratory insufficiency, recovered and developed chronic interstitial lung disease with intermittent exacerbations during early childhood. In vitro analysis showed normal transcription, processing, and targeting of ABCA3-R288K, but impaired detoxification function and smaller lamellar bodies. We propose that the R288K variant can underlie interstitial lung disease in childhood due to reduced function of ABCA3, demonstrated by decelerated detoxification of doxorubicin, reduced PC 32:0 content and decreased lamellar body volume. PMID:26928390

20 CFR 404.288 - Recomputing when you are entitled to a monthly pension based on noncovered employment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... monthly pension based on noncovered employment. 404.288 Section 404.288 Employees' Benefits SOCIAL... monthly pension based on noncovered employment. (a) After entitlement to old-age or disability insurance... later become entitled to a monthly pension based on noncovered employment, we may recompute your primary...

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cash, Jennifer N.; Rejon, Carlis A.; McPherron, Alexandra C.

2009-09-29

Myostatin is a member of the transforming growth factor-{beta} (TGF-{beta}) family and a strong negative regulator of muscle growth. Here, we present the crystal structure of myostatin in complex with the antagonist follistatin 288 (Fst288). We find that the prehelix region of myostatin very closely resembles that of TGF-{beta} class members and that this region alone can be swapped into activin A to confer signalling through the non-canonical type I receptor Alk5. Furthermore, the N-terminal domain of Fst288 undergoes conformational rearrangements to bind myostatin and likely acts as a site of specificity for the antagonist. In addition, a unique continuousmore » electropositive surface is created when myostatin binds Fst288, which significantly increases the affinity for heparin. This translates into stronger interactions with the cell surface and enhanced myostatin degradation in the presence of either Fst288 or Fst315. Overall, we have identified several characteristics unique to myostatin that will be paramount to the rational design of myostatin inhibitors that could be used in the treatment of muscle-wasting disorders.« less

Transformation of a Finite-Element Model of a Piezoelectric Spherical Shell Transducer from a Nodal to a Spherical Harmonic Function Representation

DTIC Science & Technology

1990-06-01

J) :(270, )..pTod( 301,j)s(331,j)- pcod (302.j) s(271,j)-prod(303,J)s(332,j ):prod(304,J) s(272,J) prod(305,i) s(333,j) prod(306,j) s(273,jJ.’ptod(307...j).prodf 335,J) sf348, j)-prod( 336.1) 9(288,j)-prod(337,J) of 349, j)- pcod ( 338,J) s(209, j)-prod(339,J) of 350,j)-prod( 340,J) s(290,jJ.. pCod (341,J

30 CFR 250.288 - When and how must I submit the Conceptual Plan?

Code of Federal Regulations, 2014 CFR

2014-07-01

... engineering design of the well safety control system or subsea production systems to be used after well... 30 Mineral Resources 2 2014-07-01 2014-07-01 false When and how must I submit the Conceptual Plan? 250.288 Section 250.288 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT...

18 CFR 284.288 - Code of conduct for unbundled sales service.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Code of conduct for unbundled sales service. 284.288 Section 284.288 Conservation of Power and Water Resources FEDERAL ENERGY... information upon which it billed the prices it charged for natural gas it sold pursuant to its market based...

30 CFR 250.288 - When and how must I submit the Conceptual Plan?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false When and how must I submit the Conceptual Plan? 250.288 Section 250.288 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... Plan to the Regional Director after you have decided on the general concept(s) for development and...

Reconstructed Serine 288 in the Left Flipper Region of the Rat P2X7 Receptor Stabilizes Nonsensitized States.

PubMed

Ishchenko, Yevheniia; Novosolova, Nataliia; Khafizov, Kamil; Bart, Geneviève; Timonina, Arina; Fayuk, Dmitriy; Skorinkin, Andrei; Giniatullin, Rashid

2017-07-05

Serine 275, a conserved residue of the left flipper region of ATP-gated P2X3 receptors, plays a key role in both agonist binding and receptor desensitization. It is conserved in most of the P2X receptors except P2X7 and P2X6. By combining experimental patch-clamp and modeling approaches, we explored the role of the corresponding residue in the rat P2X7 receptor (rP2X7) by replacing the phenylalanine at position 288 with serine and characterizing the membrane currents generated by either the wild-type (WT) or the mutated rP2X7 receptor. F288S, an rP2X7 mutation, slowed the deactivation subsequent to 2 and 20 s applications of 1 mM ATP. F288S also prevented sensitization (a progressive current growth) observed with the WT in response to a 20 s application of 1 mM ATP. Increasing the ATP concentration to 5 mM promoted sensitization also in the mutated rP2X7 receptor, accelerating the deactivation rate to typical WT values. YO-PRO1 uptake in cells expressing either the WT or the F288S P2X7 receptor was consistent with recorded membrane current data. Interestingly, in the human P2X7 (hP2X7) receptor, substitution Y288S did not change the deactivation rate, while the Y288F mutant generated a "rat-like" phenotype with a fast deactivation rate. Our combined experimental, kinetic, and molecular modeling data suggest that the rat F288S novel phenotype is due to a slower rate of ATP binding and/or unbinding and stabilization of nonsensitized receptor states.

Macronutrients and trace metals in soil and food crops of Isfahan Province, Iran.

PubMed

Keshavarzi, Behnam; Moore, Farid; Ansari, Maryam; Rastegari Mehr, Meisam; Kaabi, Helena; Kermani, Maryam

2015-01-01

The distribution of 10 macronutrients and trace metals in the arable soils of Isfahan Province, their phytoavailability, and associated health risks were investigated; 134 plant and 114 soil samples (from 114 crop fields) were collected and analyzed at harvesting time. Calculation of the soil pollution index (SPI) revealed that arable soil polluted by metals was more severe in the north and southwest of the study area. The results of cluster analysis indicated that Pb, Zn, and Cu share a similar origin from industries and traffic. The concentrations of macronutrients and trace metals in the sampled crops were found in the order of K > Ca > S > Mg > P and Fe > Mn > Zn > Cu > Pb, respectively, whereas calculation of the bioconcentration factor (BCF) indicated that the accumulation of the investigated elements in crops was generally in the order of S ≈ K > P > Mg > Ca and Zn > Cu > Mn > Pb > Fe, respectively. Thus, various parameters including crop species and the physical, chemical, and biological properties of soil also affected the bioavailability of the elements besides the total element contents in soil. Daily intake (DI) values of elements were lower than the recommended daily intake (RDI) levels in rice grains except for Fe and Mn, but for wheat grains, all elements displayed DI values higher than the RDI. Moreover, based on the hazard index (HI) values, inhabitants are experiencing a significant potential health risk solely due to the consumption of wheat and rice grains (particularly wheat grains). Mn health quotient (HQ) also indicated a high risk of Mn absorption for crop consumer inhabitants.

[Deficiency of selenium in pneumonia: an accident or regularity? Problem of nutriciology and gastroenterology].

PubMed

Orlov, A M; Bakulin, I G; Mazo, V K

2013-01-01

Study of features of community-acquired pneumonia in young adults with deficiency of trace element selenium and the development directions of optimization of treatment. The study of 114 patients with community-acquired pneumonia, were evaluated nutritional deficiencies, the level of selenium in the blood plasma and the efficiency of application selenium biologically active additives in treatment of community acquired pneumonia. The vast majority of the 114 patients with community-acquired pneumonia is marked by malnutrition and selenium varying degrees of symptoms. Application of selenium dietary supplement in patients with community-acquired pneumonia contributes to earlier periods of permission of pneumonia and increase outcomes from full resolution infiltrative pulmonary field changes according to the radiographic study in patients of this category.

40 CFR 97.288 - CAIR SO2 allowance allocations to CAIR SO2 opt-in units.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false CAIR SO2 allowance allocations to CAIR SO2 opt-in units. 97.288 Section 97.288 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS...

40 CFR 96.288 - CAIR SO2 allowance allocations to CAIR SO2 opt-in units.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false CAIR SO2 allowance allocations to CAIR SO2 opt-in units. 96.288 Section 96.288 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR...

{Nb288O768(OH)48(CO3)12}: A Macromolecular Polyoxometalate with Niobium Atoms Close to 300.

PubMed

Wu, Yan-Lan; Li, Xin-Xiong; Qi, Yan-Jie; Yu, Hao; Jin, Lu; Zheng, Shou-Tian

2018-05-29

A protein-sized (ca. 4.2 ᵡ 4.2 ᵡ 3.6 nm3) non-biologically derived molecule {Nb288O768(OH)48(CO3)12} (Nb288) containing up to 288 niobium atoms has been obtained, which is by far the largest and the highest nuclearity polyoxoniobate (PONb). Particularly, in terms of metal nuclearity number, Nb288 is the second largest cluster so far reported in classic polyoxometalate chemistry (V, Mo, W, Nb, and Ta). Nb288 can be described as a giant windmill-like cluster aggregate of six brand-new, nanoscale high-nuclearity PONb units {Nb47O128(OH)6(CO3)2} (Nb47) joined together by six additional Nb ions. Interestingly, the in situ generated 47-nuclearity Nb47 units can be isolated and bridged by copper complexes to form an inorganic-organic hybrid three-dimensional PONb framework, which exhibits effective catalytic activity for hydrolyzing nerve agent simulant of dimethyl methylphosphonate. The unique Nb47 cluster also provides a new type of topology to very limited family of Nb-O clusters. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Investigating the binary nature of active asteroid 288P/300163

NASA Astrophysics Data System (ADS)

Agarwal, Jessica

2016-10-01

We propose to study the suspected binary nature of active asteroid 288P/300163. We aim to confirm or disprove the existence of a binary nucleus, and - if confirmed - to measure the mutual orbital period and orbit orientation of the compoents, and their sizes. We request 5 orbits of WFC3 imaging, spaced at intervals of 8-12 days. 288P belongs to the recently discovered group of active asteroids, and is particularly remarkable as HST images obtained during its last close approach to Earth in 2011 are consistent with a barely resolved binary system. If confirmed, 288P would be the first known active binary asteroid. For the first time, we would see two important consequences of rotational break-up in a single object: binary formation and dust ejection, highlighting the importance of the YORP-effect in re-shaping the asteroid belt. Confirming 288P as a binary would be a key step towards understanding the evolutionary processes underlying asteroid activity. In order to resolve the two components we need 288P at a geocentric distance comparable to or less than we had in 2011 December (1.85 AU). This condition will be fulfilled for the first time since 2011, between mid-July and mid-November of 2016. The next opportunity to carry out such observations will be in 2021.

A systematic study of superheavy nuclei for Z = 114 and beyond using the relativistic mean field approach

NASA Astrophysics Data System (ADS)

Patra, S. K.; Wu, Cheng-Li; Praharaj, C. R.; Gupta, Raj K.

1999-05-01

We have studied the structural properties of even-even, neutron deficient, Z = 114-126, superheavy nuclei in the mass region A ˜ 270-320, using an axially deformed relativistic mean field model. The calculations are performed with three parameter sets (NL1, TM1 and NL-SH), in order to see the dependence of the structural properties on the force used. The calculated ground state shapes are found to be parameter dependent. For some parameter sets, many of the nuclei are degenerate in their ground state configuration. Special attention is given to the investigation of the magic structures (spherical shell closures) in the superheavy region. We find that some known magic numbers are absent and new closed shells are predicted. Large shell gaps appear at Z = 80, 92, (114), 120 and 138, N = 138, (164), (172), 184, (198), (228) and 258, irrespective of the parameter sets used. The numbers in parenthesis are those which correspond to relatively smaller gaps. The existence of new magic numbers in the valley of superheavy elements is discussed. It is suggested that nuclei around Z = 114 and N = 164 ˜ 172 could be considered as candidates for the next search of superheavy nuclei. The existence of superheavy islands around Z = 120 and N = 172 or N = 184 double shell closure is also discussed.

Search for naturally occurring superheavy elements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoughton, R.W.; Halperin, J.; Drury, J.S.

1973-11-12

Several ores, minerals, concentrates and special samples were examined for evidence of superheavy elements using a neutron multiplicity counter. This counter contains 20 /sup 3/He detectors in a paraffin matrix, and enables evaluation of the emitted neutron multiplicity spectrum of large samples with littie or no chemical processing. Such measurements provide an effective tool in the search for superheavy elements, since their decay or the decay of daughter nuclides is expected to proceed by spontaneous fission. In a search for Element 114(ekalead) a massive galena sample and a sample of galena-barite were examined, together with some chalcophilic samples, iron andmore » zinc sulphides, cerussite (PbCO/ sub 3/), and flux dust samples in Cottrell precipitators from the roasting of pentlandite (iron nickel sulphide). Element 114 would be expected to be more volatile than Hg, and intermediate between Pb and Au in nobility, and for this reason a technique was applied which was successfully developed to locate Hg ore bodies. This technique is described. In another attempt to detect possible volatile superheavy elements, such as 118 (ekaradon) or 112 (ekamercury) a sample of silica gel was examined, previously used in a plant for the production of noble gases; a gas mixture of crude Xe from the same plant was also investigated. With regard to Element 110 (ekaplatinum) several ultrabasic rocks were examined. For Element 119 (ekafracium) several potash ores were examined, as well as bittern from the Great Salt Lake, Utah. A sample of native Bi, as well as reagent Bi, were examined for Element 115 (ekabismuth). Several special samples included iron-rich meteorites, samples of biotite in which dwarf haloes had been found, some monazite samples associated with giant haloes, and some haematite and magnetite samples; also manganese nodules, sharks' teeth, and carbonaceous chondrite meteorite samples. The latter were particularly interesting since there is a Xe component in some carbonaceous chondrites that shows a higher /sup 136/Xe/sup 134/Xe ratio than Xe from any known fission source, possibly due to fission of one or more relatively volatile superheavy elements. All the results are summarized in tabular form. None of the samples examined showed evidence of spontaneous fission rates in excess of the detection limit. (UK)« less

Computer Resources Handbook for Flight Critical Systems.

DTIC Science & Technology

1985-01-01

8183 UNCLASSIFIED F /G 1 /3 NLllEEEEEEEEEEEE Illll lflflflflfl Illlfll..lflll EIEEIhEEIIIIII llElfllfllflfllfll .flflflflflflflflflflflll llEEEEEEllEII...Requiring Simulation .... ............. ... 114 6-4 Typical Transition Elements of Care III. ...... ............ 116 D- 1 F -16 Digital Flight Control...following forms: 1 . By reference to MIL- F -9490(for flight control systems); 2. By reference, with tailoring if required, to a Federal Aviation Regulation

VizieR Online Data Catalog: HARPS and HARPS-N 55 Cnc radial velocities (Lopez-Morales+, 2014)

NASA Astrophysics Data System (ADS)

Lopez-Morales, M.; Triaud, A. H. M. J.; Rodler, F.; Dumusque, X.; Buchhave, L. A.; Harutyunyan, A.; Hoyer, S.; Alonso, R.; Gillon, M.; Kaib, N. A.; Latham, D. W.; Lovis, C.; Pepe, F.; Queloz, D.; Raymond, S. N.; Segransan, D.; Waldmann, I. P.; Udry, S.

2017-04-01

Shortly after the detection of 55 Cnc e's transit was announced, we requested four spectroscopic time series on HARPS (Prog. ID 288.C-5010; PI: Triaud) as Director Discretionary Time. HARPS is installed on the 3.6 m telescope at the European Southern Observatory on La Silla, Chile (Mayor et al. 2003Msngr.114...20M). The position of 55 Cnc in the sky-RA(J2000)=08:52:35.81, DE(J2000)=+28:10:50.95-is low as seen from La Silla. The target remains at a zenith distance of z<2 for only ~2.5 hr per night, with a transit duration of about 1.5 hr having to fit within this tight window. This constraint on the airmass, essential to obtain precise radial velocities (RVs), is set by the instrumental atmospheric dispersion corrector. We used the ephemeris by Gillon et al. (2012, J/A+A/539/A28), then at an advanced stage of preparation, to schedule our observations. In total, we gathered 179 spectra on the nights starting on 2012 January 27, 2012 February 13, 2012 February 27, and 2012 March 15 UT. (1 data file).

Roseomonas oryzae sp. nov., isolated from paddy rhizosphere soil.

PubMed

Ramaprasad, E V V; Sasikala, Ch; Ramana, Ch V

2015-10-01

A non-motile, coccus-shaped, pale-pink-pigmented bacterium, designated strain JC288T, was isolated from a paddy rhizosphere soil collected from Western Ghats, Kankumbi, Karnataka, India. Cells were found to be Gram-stain-negative, and catalase- and oxidase-positive; the major fatty acids were C16 : 0, C16 : 1ω7c/C16 : 1ω6c, C18 : 1ω7c/C18 : 1ω6c and C18 : 1 2-OH. The predominant respiratory quinone was Q-10 and the genomic DNA G+C content was 67.5 mol%. Strain JC288T contained diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, four unidentified aminolipids, three unidentified phospholipids, two unidentified lipids, an aminophospholipid and a glycolipid. Hydroxyspirilloxanthin was the major carotenoid of strain JC288T. 16S rRNA gene sequence comparisons indicated that strain JC288T represents a member of the genus Roseomonas within the family Acetobacteraceae of the phylum Proteobacteria. Strain JC288T shared the highest 16S rRNA gene sequence similarity with Roseomonas rhizosphaerae YW11T (97.3 %), Roseomonas aestuarii JC17T (97.1 %), Roseomonas cervicalis CIP 104027T (95.9 %) and other members of the genus Roseomonas ( < 95.5 %). The distinct genomic difference and morphological, physiological and chemotaxonomic differences from the previously described taxa support the classification of strain JC288T as a representative of a novel species of the genus Roseomonas, for which the name Roseomonas oryzae sp. nov. is proposed. The type strain is JC288T ( = KCTC 42542T = LMG 28711T).

The Hot Horizontal-Branch Stars in NGC288 - Effects of Diffusion and Stratification on Their Atmospheric Parameters*

NASA Technical Reports Server (NTRS)

Moehler, S.; Dreizler, S.; LeBlanc, F.; Khalack, V.; Michaud, G.; Richer, J.; Sweigart, Allen V.; Grundahl, F.

2014-01-01

Context. NGC288 is a globular cluster with a well developed blue horizontal branch covering the so-called u-jump which indicates the onset of diffusion. It is therefore well suited to study the effects of diffusion in blue horizontal branch (HB) stars. Aims. We compare observed abundances to predictions from stellar evolution models calculated with diffusion and from stratified atmospheric models. We verify the effect of using stratified model spectra to derive atmospheric parameters. In addition we investigate the nature of the overluminous blue HB stars around the u-jump. Methods. We define a new photometric index sz from uvby measurements that is gravity sensitive between 8 000K and 12 000 K. Using medium-resolution spectra and Stroemgren photometry we determine atmospheric parameters (Teff, logg) and abundances for the blue HB stars. We use both homogeneous and stratified model spectra for our spectroscopic analyses. Results. The atmospheric parameters and masses of the hot HB stars in NGC288 show a behaviour seen also in other clusters for temperatures between 9 000K and 14 000 K. Outside this temperature range, however, they follow rather the results found for such stars in (omega)Cen. The abundances derived from our observations are for most elements (except He and P) within the abundance range expected from evolutionary models that include the effects of atomic diffusion and assume a surface mixed mass of 10(exp -7) M. The abundances predicted by stratified model atmospheres are generally significantly more extreme than observed, except for Mg. The use of stratified model spectra to determine effective temperatures, surface gravities and masses moves the hotter stars to a closer agreement with canonical evolutionary predictions. Conclusions. Our results show definite promise towards solving the long-standing issue of surface gravity and mass discrepancies for hot HB stars, but there is still much work needed to arrive at a self-consistent solution.

Effect of Service Environment on Composite Materials

DTIC Science & Technology

1980-08-01

AGARC -CP-288 . z AGARD Conference Procee•dings No.288 Effect of Service Environment on Composite Materials M1TflIBInj4 STATE 9s~k 7- II LLU...ORGANISATION DU TRAITE DE L’ATLANTI )UE NOR3) AGARD Conference Proceedings 1, o.288 EFFECT OF SERVICE ENVIRONM ENT ONj I COMPOSITE MATERIALS --- I... composites soumis aux divers types d’agressions que l’on recouvre aujourd’hui du vocable d’...environnement". On doit admettre que cette revue 6tait part

2 CFR 25.330 - Foreign public entity.

Code of Federal Regulations, 2013 CFR

2013-01-01

... organization, which is an organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f); (c) An...

2 CFR 25.330 - Foreign public entity.

Code of Federal Regulations, 2012 CFR

2012-01-01

... organization, which is an organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f); (c) An...

2 CFR 25.330 - Foreign public entity.

Code of Federal Regulations, 2011 CFR

2011-01-01

... organization, which is an organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f); (c) An...

2 CFR 200.46 - Foreign public entity.

Code of Federal Regulations, 2014 CFR

2014-01-01

... organization, which is an organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f); (c) An...

Spacesuit guidebook

NASA Technical Reports Server (NTRS)

1991-01-01

This guidebook is designed to supplement the Spacesuit wall chart (WAL-114) published by the Education Affairs Division, January 1990. The wall chart depicts Astronaut Bruce McCandless on his historic first untethered spacewalk using the manned maneuvering unit. He flew on Shuttle mission 41-B, and ventured 100 meters for the Shuttle's cargo bay and returned safely. This guidebook explains in depth the elements depicted on the wall chart in see-through and cut-away perspectives. Together the wall chart and guidebook show as well as explain the inside workings of the spacesuit and its various components. Forty separate elements are identified with an accompanying numerical legend. Those elements are further explained in this guidebook along with their functions and how they work in relation to other elements. Additional chapters discuss essential components of the spacesuit such as the primary life support system and the manned maneuvering unit, and the method for donning the spacesuit.

2 CFR 25.330 - Foreign public entity.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., which is an organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f); (c) An entity owned (in...

Thermal oxidative degradation reactions of linear perfluoroalky lethers

NASA Technical Reports Server (NTRS)

Jones, W. R., Jr.; Paciorek, K. J. L.; Ito, T. I.; Kratzer, R. H.

1982-01-01

Thermal and thermal oxidative stability studies were performed on linear perfluoro alkyl ether fluids. The effect on degradation by metal catalysts and degradation inhibitors are reported. The liner perfluoro alkylethers are inherently unstable at 316 C in an oxidizing atmosphere. The metal catalysts greatly increased the rate of degradation in oxidizing atmospheres. In the presence of these metals in an oxidizing atmosphere, the degradation inhibitors were highly effective in arresting degradation at 288 C. However, the inhibitors had only limited effectiveness at 316 C. The metals promote degradation by chain scission. Based on elemental analysis and oxygen consumption data, the linear perfluoro alkylether fluids have a structural arrangement based on difluoroformyl and tetrafluoroethylene oxide units, with the former predominating.

a Plutonium Ceramic Target for Masha

NASA Astrophysics Data System (ADS)

Wilk, P. A.; Shaughnessy, D. A.; Moody, K. J.; Kenneally, J. M.; Wild, J. F.; Stoyer, M. A.; Patin, J. B.; Lougheed, R. W.; Ebbinghaus, B. B.; Landingham, R. L.; Oganessian, Yu. Ts.; Yeremin, A. V.; Dmitriev, S. N.

2005-09-01

We are currently developing a plutonium ceramic target for the MASHA mass separator. The MASHA separator will use a thick plutonium ceramic target capable of tolerating temperatures up to 2000 °C. Promising candidates for the target include oxides and carbides, although more research into their thermodynamic properties will be required. Reaction products will diffuse out of the target into an ion source, where they will then be transported through the separator to a position-sensitive focal-plane detector array. Experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments where the chemical properties of the heaviest elements are studied.

High Rate User Ka-Band Phased Array Antenna Test Results

NASA Technical Reports Server (NTRS)

Caroglanian, Armen; Perko, Kenneth; Seufert, Steve; Dod, Tom; Warshowsky, Jay; Day, John H. (Technical Monitor)

2001-01-01

The High Rate User Phased Array Antenna (HRUPAA) is a Ka-Band planar phased array designed by the Harris Corporation for the NASA Goddard Space Flight Center. The HRUPAA permits a satellite to downlink data either to a ground station or through the Tracking and Data Relay Satellite System (TDRSS). The HRUPAA is scanned electronically by ground station / user satellite command over a 120 degree cone angle. The phased array has the advantage of not imparting attitude disturbances to the user spacecraft. The 288-element transmit-only array has distributed RF amplifiers integrated behind each of the printed patch antenna elements. The array has 33 dBW EIRP and is left-hand circularly polarized. An engineering model of a partially populated array has been developed and delivered to NASA Goddard Space Flight Center. This report deals with the testing of the engineering model at the Goddard Antenna Range near-field and compact range facilities. The antenna specifications are described first, followed by the test plan and test results.

Diarrhoea in slum children: observation from a large diarrhoeal disease hospital in Dhaka, Bangladesh.

PubMed

Ferdous, Farzana; Das, Sumon Kumar; Ahmed, Shahnawaz; Farzana, Fahmida Dil; Malek, Mohammad Abdul; Das, Jui; Latham, Jonathan Ross; Faruque, Abu Syed Golam; Chisti, Mohammod Jobayer

2014-10-01

To determine and compare socio-demographic, nutritional and clinical characteristics of children under five with diarrhoea living in slums with those of children who do not live in slums of Dhaka, Bangladesh. From 1993 to 2012, a total of 28 948 under fives children with diarrhoea attended the Dhaka Hospital of icddr,b. Data were extracted from the hospital-based Diarrhoea Disease Surveillance System, which comprised 17 548 under fives children from slum and non-slum areas of the city. Maternal illiteracy [aOR = 1.57; 95% confidence interval (1.36, 1.81), P-value <0.001], paternal illiteracy [1.37 (1.21, 1.56) <0.001], mother's employment [1.59 (1.37, 1.85) <0.001], consumption of untreated water [2.73 (2.26, 3.30) <0.001], use of non-sanitary toilets [3.48 (3.09, 3.93) <0.001], 1st wealth quintile background [3.32 (2.88, 3.84) <0.001], presence of fever [1.14 (1.00, 1.29) 0.047], some or severe dehydration [1.21 (1.06, 1.40) 0.007], stunting [1.14 (1.01, 1.29) 0.030] and infection with Vibrio cholerae [1.21 (1.01, 1.45) 0.039] were significantly associated with slum-dwelling children after controlling for co-variates. Measles immunisation [0.52 (0.47, 0.59) P < 0.001] and vitamin A supplementation rates [0.36 (0.31, 0.41) P < 0.001] amongst children 12-59 months were lower for slum dwellers than other children in univarate analysis only. Slum-dwelling children are more malnourished, have lower immunisation rates (measles vaccination and vitamin A supplementation) and higher rates of measles, are more susceptible to diarrhoeal illness due to V. cholerae and suffer from severe dehydration more often than children from non-slum areas. Improved health and nutrition strategies should give priority to children living in urban slums. © 2014 John Wiley & Sons Ltd.

Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmad, Md. Faiz; Kaushal, Prem Singh; Wan, Qun

2012-11-01

Ribonucleotide reductases (RRs) catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Eukaryotic RRs consist of two proteins, RR1 ({alpha}) that contains the catalytic site and RR2 ({beta}) that houses a diferric-tyrosyl radical essential for ribonucleoside diphosphate reduction. Biochemical analysis has been combined with isothermal titration calorimetry (ITC), X-ray crystallography and yeast genetics to elucidate the roles of two loop 2 mutations R293A and Q288A in Saccharomyces cerevisiae RR1 (ScRR1). These mutations, R293A and Q288A, cause lethality and severe S phase defects, respectively, in cells that use ScRR1 as the sole source of RR1 activity. Compared to the wild-typemore » enzyme activity, R293A and Q288A mutants show 4% and 15%, respectively, for ADP reduction, whereas they are 20% and 23%, respectively, for CDP reduction. ITC data showed that R293A ScRR1 is unable to bind ADP and binds CDP with 2-fold lower affinity compared to wild-type ScRR1. With the Q288A ScRR1 mutant, there is a 6-fold loss of affinity for ADP binding and a 2-fold loss of affinity for CDP compared to the wild type. X-ray structures of R293A ScRR1 complexed with dGTP and AMPPNP-CDP [AMPPNP, adenosine 5-({beta},{gamma}-imido)triphosphate tetralithium salt] reveal that ADP is not bound at the catalytic site, and CDP binds farther from the catalytic site compared to wild type. Our in vivo functional analyses demonstrated that R293A cannot support mitotic growth, whereas Q288A can, albeit with a severe S phase defect. Taken together, our structure, activity, ITC and in vivo data reveal that the arginine 293 and glutamine 288 residues of ScRR1 are crucial in facilitating ADP and CDP substrate selection.« less

Thermodynamic Study of Solid-Liquid Equilibrium in NaCl-NaBr-H2O System at 288.15 K

NASA Astrophysics Data System (ADS)

Li, Dan; Meng, Ling-zong; Deng, Tian-long; Guo, Ya-fei; Fu, Qing-Tao

2018-06-01

The solubility data, composition of the solid solution and refractive indices of the NaCl-NaBr-H2O system at 288.15 K were studied with the isothermal equilibrium dissolution method. The solubility diagram and refractive index diagram of this system were plotted at 288.15 K. The solubility diagram consists of two crystallization zones for solid solution Na(Cl,Br) · 2H2O and Na(Cl,Br), one invariant points cosaturated with two solid solution and two univariant solubility isothermal curves. On the basis of Pitzer and Harvie-Weare (HW) chemical models, the composition equations and solubility equilibrium constant equations of the solid solutions at 288.15 K were acquired using the solubility data, the composition of solid solutions, and binary Pitzer parameters. The solubilities calculated using the new method combining the equations are in good agreement with the experimental data.

KENNEDY SPACE CENTER, FLA. - Members of the STS-114 crew take a look at the Japanese Experiment Module (JEM) pressure module in the Space Station Processing Facility. A research laboratory, the pressurized module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo and is Japan's primary contribution to the Station. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

NASA Image and Video Library

2003-06-09

KENNEDY SPACE CENTER, FLA. - Members of the STS-114 crew take a look at the Japanese Experiment Module (JEM) pressure module in the Space Station Processing Facility. A research laboratory, the pressurized module is the first element of the JEM, named "Kibo" (Hope), to be delivered to KSC. The National Space Development Agency of Japan (NASDA) developed the laboratory at the Tsukuba Space Center near Tokyo and is Japan's primary contribution to the Station. The JEM also includes an exposed facility (platform) for space environment experiments, a robotic manipulator system, and two logistics modules. The various JEM components will be assembled in space over the course of three Shuttle missions.

Are we developing walkable suburbs through urban planning policy? Identifying the mix of design requirements to optimise walking outcomes from the 'Liveable Neighbourhoods' planning policy in Perth, Western Australia.

PubMed

Hooper, Paula; Knuiman, Matthew; Bull, Fiona; Jones, Evan; Giles-Corti, Billie

2015-05-16

Planning policy makers and practitioners are requesting clearer guidance on the 'essential' ingredients as assessed by public health researchers to ensure suburban neighbourhood environments are designed to promote active living behaviours such as walking. To identify the combination of design requirements from the 'Liveable Neighbourhoods' (LN) planning policy in Perth, Western Australia that were optimally supportive of walking. K-means cluster analysis identified groups of developments with homogeneous LN features from its community design (CD), movement network (MN), lot layout (LL) and public parkland (PP) elements. Walking behaviours measured using the Neighbourhood Physical Activity Questionnaire were compared between participants resident in the different clusters, adjusting for demographic characteristics, self-selection factors, stage of construction and scale of development. Compared with participants living in the referent cluster of 'poor CD and PP developments' those living in: 'MN and LL developments' had higher odds of doing any (OR = 1.74; 95 % CI = 1.22, 2.48) and ≥60 min walking for recreation (WR) (OR = 2.05; 1.46, 2.88); 'PP developments' had increased odds of doing any WR (OR = 3.53; 2.02, 6.17), ≥60 min WR (OR = 3.37; 1.98, 5.74) and any total walking (TW) (OR = 2.35; 1.36, 4.09); 'CD-MN developments' had increased odds of doing any walking for transport (WT) (OR = 2.64; 1.38, 5.06), ≥60 min WT (OR = 1.98; 1.09, 3.61), any TW (OR = 1.71; 1.44, 2.03), ≥60 min TW (OR = 1.77; 1.14, 2.76) and ≥150 min TW (OR = 1.47; 1.15, 1.86). This study is the first to have empirically identified a mix of specific and distinguishing planning policy neighbourhood design requirements to optimise walking outcomes. These findings will assist in the assessment of urban plans for greenfield suburban developments designed to promote walking and physical activity.

Mercury emissions to the atmosphere from natural and anthropogenic sources in the Mediterranean region

NASA Astrophysics Data System (ADS)

Pirrone, N.; Costa, P.; Pacyna, J. M.; Ferrara, R.

This report discusses past, current and projected mercury emissions to the atmosphere from major industrial sources, and presents a first assessment of the contribution to the regional mercury budget from selected natural sources. Emissions (1995 estimates) from fossil fuels combustion (29.8 t yr -1) , cement production (28.8 t yr -1) and incineration of solid wastes (27.6 t yr -1) , all together account for about 82% of the regional anthropogenic total (105.7 t yr -1) . Other industrial sources in the region are smelters (4.8 t yr -1) , iron-steel plants (4.8 t yr -1) and other minor sources (chlor-alkali plants, crematoria, chemicals production) that have been considered together in the miscellaneous category (9.6 t yr -1) . Regional emissions from anthropogenic sources increased at a rate of 3% yr-1 from 1983 to 1995 and are projected to increase at a rate of 1.9% yr-1 in the next 25 years, if no improvement in emission control policy occurs. On a country-by-country basis, France is the leading emitter country with 22.6 t yr -1 followed by Turkey (16.1 t yr -1) , Italy (11.4 t yr -1) , Spain (9.1 t yr -1) , the former Yugoslavia 7.9 ( t yr -1) , Morocco (6.9 t yr -1) , Bulgaria (6.8 t yr -1) , Egypt (6.1 t yr -1) , Syria (3.6 t yr -1) , Libya (2.9 t yr -1) , Tunisia (2.8 t yr -1) and Greece (2.7 t yr -1) , whereas the remaining countries account for less than 7% of the regional total. The annual emission from natural sources is 110 t yr -1, although this figure only includes the volatilisation of elemental mercury from surface waters and emissions from volcanoes, whereas the contribution due to the degassing of mercury from top soil and vegetation has not been included in this first assessment. Therefore, natural and anthropogenic sources in the Mediterranean region release annually about 215 t of mercury, which represents a significant contribution to the total mercury budget released in Europe and to the global atmosphere.

17 CFR 288.101 - Schedule A. Information required in reports pursuant to § 288.3.

Code of Federal Regulations, 2010 CFR

2010-04-01

... practicable, the itemization shall include transfer agents' fees, cost of printing and engraving, and legal and accounting fees. The information may be given as subject to future contingencies. If the amounts...

Trace elements in animal-based food from Shanghai markets and associated human daily intake and uptake estimation considering bioaccessibility.

PubMed

Lei, Bingli; Chen, Liang; Hao, Ying; Cao, Tiehua; Zhang, Xinyu; Yu, Yingxin; Fu, Jiamo

2013-10-01

The concentrations of four human essential trace elements [iron (Fe), manganese (Mn), zinc (Zn), chromium (Cr)] and non-essential elements [cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg)] in eighteen animal-based foods including meat, fish, and shellfish collected from markets in Shanghai, China, were analyzed, and the associated human daily intake and uptake considering bioaccessibility were estimated. The mean concentration ranges for eight trace elements measured in the foods were 3.98-131µgg(-1) for Fe, 0.437-18.5µgg(-1) for Mn, 5.47-53.8µgg(-1) for Zn, none detected-0.101µgg(-1) for Cr, 2.88×10(-4)-2.48×10(-2)µgg(-1) for Cd, 1.18×10(-3)-0.747µgg(-1) for Pb, none detected-0.498µgg(-1) for As, and 8.98×10(-4)-6.52×10(-2)µgg(-1) for Hg. The highest mean concentrations of four human essential elements were all found in shellfish. For all the trace elements, the observed mean concentrations are mostly in agreement with the reported values around the world. The total daily intake of trace elements via ingestion of animal-based food via an average Shanghai resident was estimated as 7371µgd(-1) for the human essential elements and 13.0µgd(-1) for the human non-essential elements, but the uptake decreased to 4826µgd(-1) and 6.90µgd(-1), respectively, after trace element bioaccessibility was considered. Livestock and fish for human essential and non-essential elements, respectively, were the main contributor, no matter whether the bioaccessibility was considered or not. Risk estimations showed that the intake and uptake of a signal trace element for an average Shanghai resident via ingestion animal-based foods from Shanghai markets do not exceed the recommended dietary allowance values; consequently, a health risk situation is not indicated. Copyright © 2013. Published by Elsevier Inc.

Cloud point extraction and flame atomic absorption spectrometric determination of cadmium and nickel in drinking and wastewater samples.

PubMed

Naeemullah; Kazi, Tasneem G; Shah, Faheem; Afridi, Hassan I; Baig, Jameel Ahmed; Soomro, Abdul Sattar

2013-01-01

A simple method for the preconcentration of cadmium (Cd) and nickel (Ni) in drinking and wastewater samples was developed. Cloud point extraction has been used for the preconcentration of both metals, after formation of complexes with 8-hydroxyquinoline (8-HQ) and extraction with the surfactant octylphenoxypolyethoxyethanol (Triton X-114). Dilution of the surfactant-rich phase with acidified ethanol was performed after phase separation, and the Cd and Ni contents were measured by flame atomic absorption spectrometry. The experimental variables, such as pH, amounts of reagents (8-HQ and Triton X-114), temperature, incubation time, and sample volume, were optimized. After optimization of the complexation and extraction conditions, enhancement factors of 80 and 61, with LOD values of 0.22 and 0.52 microg/L, were obtained for Cd and Ni, respectively. The proposed method was applied satisfactorily for the determination of both elements in drinking and wastewater samples.

Graphite furnace atomic absorption spectrometric determination of vanadium after cloud point extraction in the presence of graphene oxide

NASA Astrophysics Data System (ADS)

López-García, Ignacio; Marín-Hernández, Juan José; Hernández-Córdoba, Manuel

2018-05-01

Vanadium (V) and vanadium (IV) in the presence of a small concentration of graphene oxide (0.05 mg mL-1) are quantitatively transferred to the coacervate obtained with Triton X-114 in a cloud point microextraction process. The surfactant-rich phase is directly injected into the graphite atomizer of an atomic absorption spectrometer. Using a 10-mL aliquot sample and 150 μL of a 15% Triton X-114 solution, the enrichment factor for the analyte is 103, which results in a detection limit of 0.02 μg L-1 vanadium. The separation of V(V) and V(IV) using an ion-exchanger allows speciation of the element at low concentrations. Data for seven reference water samples with certified vanadium contents confirm the reliability of the procedure. Several beer samples are also analyzed, those supplied as canned drinks showing low levels of tetravalent vanadium.

Going to sleep in the supine position is a modifiable risk factor for late pregnancy stillbirth; Findings from the New Zealand multicentre stillbirth case-control study

PubMed Central

Thompson, John M. D.; Cronin, Robin S.; Li, Minglan; Stacey, Tomasina; Stone, Peter R.; Lawton, Beverley A.; Ekeroma, Alec J.; Mitchell, Edwin A.

2017-01-01

Objective Our objective was to test the primary hypothesis that maternal non-left, in particular supine going-to-sleep position, would be a risk factor for late stillbirth (≥28 weeks of gestation). Methods A multicentre case-control study was conducted in seven New Zealand health regions, between February 2012 and December 2015. Cases (n = 164) were women with singleton pregnancies and late stillbirth, without congenital abnormality. Controls (n = 569) were women with on-going singleton pregnancies, randomly selected and frequency matched for health region and gestation. The primary outcome was adjusted odds of late stillbirth associated with self-reported going-to-sleep position, on the last night. The last night was the night before the late stillbirth was thought to have occurred or the night before interview for controls. Going-to-sleep position on the last night was categorised as: supine, left-side, right-side, propped or restless. Multivariable logistic regression adjusted for known confounders. Results Supine going-to-sleep position on the last night was associated with increased late stillbirth risk (adjusted odds ratios (aOR) 3.67, 95% confidence interval (CI) 1.74 to 7.78) with a population attributable risk of 9.4%. Other independent risk factors for late stillbirth (aOR, 95% CI) were: BMI (1.04, 1.01 to 1.08) per unit, maternal age ≥40 (2.88, 1.31 to 6.32), birthweight <10th customised centile (2.76, 1.59 to 4.80), and <6 hours sleep on the last night (1.81, 1.14 to 2.88). The risk associated with supine-going-to-sleep position was greater for term (aOR 10.26, 3.00 to 35.04) than preterm stillbirths (aOR 3.12, 0.97 to 10.05). Conclusions Supine going-to-sleep position is associated with a 3.7 fold increase in overall late stillbirth risk, independent of other common risk factors. A public health campaign encouraging women not to go-to-sleep supine in the third trimester has potential to reduce late stillbirth by approximately 9%. PMID:28609468

KSC-04pd0524

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - The STS-114 crew pose for a photo in front of a solid rocket booster aft skirt in the SRB Assembly and Refurbishment Facility. In front, from left, are Cynthia Perrons, electrical technician with United Space Alliance; Commander Eileen Collins, Pilot James Kelly, and Mission Specialists Charles Camarda and Andrew Thomas. In back are Paul Gutierrez, associate program manager in SRB Element, USA; John Cleary Jr., electrical engineer with USA; Mike Leppert, project lead, Manufacturing Operations, USA; Don Noah, Materials and Processes engineer, USA; Bob Herman, deputy associate program manager, SRB Element, USA; Mission Specialist Soichi Noguchi; Dale Marlow, thermal protection system engineer with USA; Mission Specialist Stephen Robinson; Greg Henry, director, Manufacturing Operations, USA.

Crosstalk-free operation of multielement superconducting nanowire single-photon detector array integrated with single-flux-quantum circuit in a 0.1 W Gifford-McMahon cryocooler.

PubMed

Yamashita, Taro; Miki, Shigehito; Terai, Hirotaka; Makise, Kazumasa; Wang, Zhen

2012-07-15

We demonstrate the successful operation of a multielement superconducting nanowire single-photon detector (SSPD) array integrated with a single-flux-quantum (SFQ) readout circuit in a compact 0.1 W Gifford-McMahon cryocooler. A time-resolved readout technique, where output signals from each element enter the SFQ readout circuit with finite time intervals, revealed crosstalk-free operation of the four-element SSPD array connected with the SFQ readout circuit. The timing jitter and the system detection efficiency were measured to be 50 ps and 11.4%, respectively, which were comparable to the performance of practical single-pixel SSPD systems.

A Plutonium Ceramic Target for MASHA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilk, P A; Shaughnessy, D A; Moody, K J

2004-07-06

We are currently developing a plutonium ceramic target for the MASHA mass separator. The MASHA separator will use a thick plutonium ceramic target capable of tolerating temperatures up to 2000 C. Promising candidates for the target include oxides and carbides, although more research into their thermodynamic properties will be required. Reaction products will diffuse out of the target into an ion source, where they will then be transported through the separator to a position-sensitive focal-plane detector array. Experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments wheremore » the chemical properties of the heaviest elements are studied.« less

One-on-one care management and procurement of Naloxone for ambulatory use.

PubMed

Whittington, Richard; Whittington, Kathleen; Whittington, John; Porter, Joel; Zimmermann, Karla; Case, Holly; Berg, Stacey

2018-02-16

Morbidity and mortality from prescription opioids has reached unprecedented levels. Opioids remain part of chronic pain treatment in primary care. This study was designed to determine whether one-on-one care management increases procurement of Naloxone, an opioid antagonist shown to reduce morbidity and mortality in opioid overdoses. Participants included all patients ≥18 years enrolled in a primary care-based chronic pain management program and who were prescribed a daily dose of opioids for treatment of chronic pain. In total, 153 patients chose to participate. Each had a 1 h one-on-one education meeting with a registered nurse. Among the enrolled, eight patients (5.2%) had procured Naloxone prior to intervention. Overall, 31 additional patients (20.2%) procured Naloxone after intervention, a 288% relative improvement in the attainment of Naloxone (P < 0.0001) (χ2 = 29.032 with 1 degree freedom). Of the 114 participants who never procured Naloxone, 69.3% believed it was unnecessary, 20% forgot about Naloxone, 8% said it was cost prohibitive, 3.5% had access concerns and 0.9% had concerns about side effects. Direct one-on-one nurse care management sessions were associated with an increased procurement of Naloxone in a primary care-based pain management program. A significant number of patients believed Naloxone was unnecessary after the intervention.

Validation of the A&D BP UB-542 wrist device for home blood pressure measurement according to the European Society of Hypertension International Protocol revision 2010.

PubMed

Saladini, Francesca; Benetti, Elisabetta; Fania, Claudio; Palatini, Paolo

2013-08-01

The objective of this study was to determine the accuracy of the A&D BP UB-542 wrist device for home blood pressure (BP) measurement according to the International Protocol of the European Society of Hypertension (ESH). Device evaluation was carried out in 33 patients. The mean age was 50.9±10.1 years, the mean systolic BP was 141.6±22.8 mmHg (range 92 : 189), the mean diastolic BP was 89.2±11.4 mmHg (range 62 : 120), the mean arm circumference was 28.8±3.2 cm (range 23-35), and the mean wrist circumference was 17.1±1.4 cm (range 14-19.5). The protocol requirements were followed precisely. The device passed all requirements, fulfilling the standards of the protocol. On average, the device overestimated the systolic BP by 1.8±7.2 mmHg and diastolic BP by 1.6±5.7 mmHg. These data show that the A&D BP UB-542 wrist device met the requirements for validation by the International Protocol and can be recommended for clinical use in the adult population.

Assessment of the Antimicrobial Activity of Algae Extracts on Bacteria Responsible of External Otitis

PubMed Central

Pane, Gianluca; Cacciola, Gabriele; Giacco, Elisabetta; Mariottini, Gian Luigi; Coppo, Erika

2015-01-01

External otitis is a diffuse inflammation around the external auditory canal and auricle, which is often occurred by microbial infection. This disease is generally treated using antibiotics, but the frequent occurrence of antibiotic resistance requires the development of new antibiotic agents. In this context, unexplored bioactive natural candidates could be a chance for the production of targeted drugs provided with antimicrobial activity. In this paper, microbial pathogens were isolated from patients with external otitis using ear swabs for over one year, and the antimicrobial activity of the two methanol extracts from selected marine (Dunaliella salina) and freshwater (Pseudokirchneriella subcapitata) microalgae was tested on the isolated pathogens. Totally, 114 bacterial and 11 fungal strains were isolated, of which Staphylococcus spp. (28.8%) and Pseudomonas aeruginosa (P. aeruginosa) (24.8%) were the major pathogens. Only three Staphylococcus aureus (S. aureus) strains and 11 coagulase-negative Staphylococci showed resistance to methicillin. The two algal extracts showed interesting antimicrobial properties, which mostly inhibited the growth of isolated S. aureus, P. aeruginosa, Escherichia coli, and Klebsiella spp. with MICs range of 1.4 × 109 to 2.2 × 1010 cells/mL. These results suggest that the two algae have potential as resources for the development of antimicrobial agents. PMID:26492256

Saccharomyces cerevisiae FLO1 Gene Demonstrates Genetic Linkage to Increased Fermentation Rate at Low Temperatures

PubMed Central

Deed, Rebecca C.; Fedrizzi, Bruno; Gardner, Richard C.

2017-01-01

Low fermentation temperatures are of importance to food and beverage industries working with Saccharomyces cerevisiae. Therefore, the identification of genes demonstrating a positive impact on fermentation kinetics is of significant interest. A set of 121 mapped F1 progeny, derived from a cross between haploid strains BY4716 (a derivative of the laboratory yeast S288C) and wine yeast RM11-1a, were fermented in New Zealand Sauvignon Blanc grape juice at 12.5°. Analyses of five key fermentation kinetic parameters among the F1 progeny identified a quantitative trait locus (QTL) on chromosome I with a significant degree of linkage to maximal fermentation rate (Vmax) at low temperature. Independent deletions of two candidate genes within the region, FLO1 and SWH1, were constructed in the parental strains (with S288C representing BY4716). Fermentation of wild-type and deletion strains at 12.5 and 25° confirmed that the genetic linkage to Vmax corresponds to the S288C version of the FLO1 allele, as the absence of this allele reduced Vmax by ∼50% at 12.5°, but not at 25°. Reciprocal hemizygosity analysis (RHA) between S288C and RM11-1a FLO1 alleles did not confirm the prediction that the S288C version of FLO1 was promoting more rapid fermentation in the opposing strain background, suggesting that the positive effect on Vmax derived from S288C FLO1 may only provide an advantage in haploids, or is dependent on strain-specific cis or trans effects. This research adds to the growing body of evidence demonstrating the role of FLO1 in providing stress tolerance to S. cerevisiae during fermentation. PMID:28143947

The Use of Spray-Dried Mn₃O₄/C Composites as Electrocatalysts for Li-O₂ Batteries.

PubMed

Yang, Hong-Kai; Chin, Chih-Chun; Chen, Jenn-Shing

2016-11-07

The electrocatalytic activities of Mn₃O₄/C composites are studied in lithium-oxygen (Li-O₂) batteries as cathode catalysts. The Mn₃O₄/C composites are fabricated using ultrasonic spray pyrolysis (USP) with organic surfactants as the carbon sources. The physical and electrochemical performance of the composites is characterized by X-ray diffraction, scanning electron microscopy, particle size analysis, Brunauer-Emmett-Teller (BET) measurements, elemental analysis, galvanostatic charge-discharge methods and rotating ring-disk electrode (RRDE) measurements. The electrochemical tests demonstrate that the Mn₃O₄/C composite that is prepared using Trition X-114 (TX114) surfactant has higher activity as a bi-functional catalyst and delivers better oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalytic performance in Li-O₂ batteries because there is a larger surface area and particles are homogeneous with a meso/macro porous structure. The rate constant ( k f ) for the production of superoxide radical (O₂ • - ) and the propylene carbonate (PC)-electrolyte decomposition rate constant ( k ) for M₃O₄/C and Super P electrodes are measured using RRDE experiments and analysis in the 0.1 M tetrabutylammonium hexafluorophosphate (TBAPF₆)/PC electrolyte. The results show that TX114 has higher electrocatalytic activity for the first step of ORR to generate O₂ • - and produces a faster PC-electrolyte decomposition rate.

Thermal oxidative degradation reactions of linear perfluoroalkyl ethers

NASA Technical Reports Server (NTRS)

Jones, W. R., Jr.; Paclorek, K. J. L.; Ito, T. I.; Kratzer, R. H.

1983-01-01

Thermal and thermal oxidative stability studies were performed on linear perfluoroalkyl ether fluids. The effect on degradation by metal catalysts and degradation inhibitors is reported. The linear perfluoroalkyl ethers are inherently unstable at 316 C in an oxidizing atmosphere. The metal catalysts greatly increased the rate of degradation in oxidizing atmospheres. In the presence of these metals in an oxidizing atmosphere, the degradation inhibitors were highly effective in arresting degradation at 288 C. However, the inhibitors had only limited effectiveness at 316 C. The metals promote degradation by chain scission. Based on elemental analysis and oxygen consumption data, the linear perfluoroalkyl ether fluids have a structural arrangement based on difluoroformyl and tetrafluoroethylene oxide units, with the former predominating. Previously announced in STAR as N82-26468

Chemistry of the superheavy elements.

PubMed

Schädel, Matthias

2015-03-13

The quest for superheavy elements (SHEs) is driven by the desire to find and explore one of the extreme limits of existence of matter. These elements exist solely due to their nuclear shell stabilization. All 15 presently 'known' SHEs (11 are officially 'discovered' and named) up to element 118 are short-lived and are man-made atom-at-a-time in heavy ion induced nuclear reactions. They are identical to the transactinide elements located in the seventh period of the periodic table beginning with rutherfordium (element 104), dubnium (element 105) and seaborgium (element 106) in groups 4, 5 and 6, respectively. Their chemical properties are often surprising and unexpected from simple extrapolations. After hassium (element 108), chemistry has now reached copernicium (element 112) and flerovium (element 114). For the later ones, the focus is on questions of their metallic or possibly noble gas-like character originating from interplay of most pronounced relativistic effects and electron-shell effects. SHEs provide unique opportunities to get insights into the influence of strong relativistic effects on the atomic electrons and to probe 'relativistically' influenced chemical properties and the architecture of the periodic table at its farthest reach. In addition, they establish a test bench to challenge the validity and predictive power of modern fully relativistic quantum chemical models. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl.

PubMed Central

Matsumoto, M; Imagawa, M; Aoki, Y

1999-01-01

3,3',4,4',5-Pentachlorobiphenyl (PenCB), one of the most toxic co-planar polychlorinated biphenyl congeners, specifically induces class Pi glutathione S-transferase (GSTP1) as well as cytochrome P-450 1A1 in primary cultured rat liver parenchymal cells [Aoki, Matsumoto and Suzuki (1993) FEBS Lett. 333, 114-118]. However, the 5'-flanking sequence of the GSTP1 gene does not contain a xenobiotic responsive element, to which arylhydrocarbon receptor binds. Using a chloramphenicol acetyltransferase assay we demonstrate here that the enhancer termed GSTP1 enhancer I (GPEI) is necessary for the stimulation by PenCB of GSTP1 gene expression in primary cultured rat liver parenchymal cells. GPEI is already known to contain a dyad of PMA responsive element-like elements oriented palindromically. It is suggested that a novel signal transduction pathway activated by PenCB contributes to the stimulation of GSTP1 expression. PMID:10051428

Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.

PubMed

Barazzuol, Lara; Rickett, Nicole; Ju, Limei; Jeggo, Penny A

2015-10-01

The embryonic neural stem cell compartment is characterised by rapid proliferation from embryonic day (E)11 to E16.5, high endogenous DNA double-strand break (DSB) formation and sensitive activation of apoptosis. Here, we ask whether DSBs arise in the adult neural stem cell compartments, the sub-ventricular zone (SVZ) of the lateral ventricles and the sub-granular zone (SGZ) of the hippocampal dentate gyrus, and whether they activate apoptosis. We used mice with a hypomorphic mutation in DNA ligase IV (Lig4(Y288C)), ataxia telangiectasia mutated (Atm(-/-)) and double mutant Atm(-/-)/Lig4(Y288C) mice. We demonstrate that, although DSBs do not arise at a high frequency in adult neural stem cells, the low numbers of DSBs that persist endogenously in Lig4(Y288C) mice or that are induced by low radiation doses can activate apoptosis. A temporal analysis shows that DSB levels in Lig4(Y288C) mice diminish gradually from the embryo to a steady state level in adult mice. The neonatal SVZ compartment of Lig4(Y288C) mice harbours diminished DSBs compared to its differentiated counterpart, suggesting a process selecting against unfit stem cells. Finally, we reveal high endogenous apoptosis in the developing SVZ of wild-type newborn mice. © 2015. Published by The Company of Biologists Ltd.

26 CFR 31.3121(b)(15)-1 - Services in employ of international organization.

Code of Federal Regulations, 2014 CFR

2014-04-01

... organization. (a) Subject to the provisions of section 1 of the International Organizations Immunities Act (22... public international organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2...

26 CFR 31.3121(b)(15)-1 - Services in employ of international organization.

Code of Federal Regulations, 2012 CFR

2012-04-01

... organization. (a) Subject to the provisions of section 1 of the International Organizations Immunities Act (22... public international organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2...

26 CFR 31.3121(b)(15)-1 - Services in employ of international organization.

Code of Federal Regulations, 2013 CFR

2013-04-01

... organization. (a) Subject to the provisions of section 1 of the International Organizations Immunities Act (22... public international organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2...

26 CFR 31.3121(b)(15)-1 - Services in employ of international organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... organization. (a) Subject to the provisions of section 1 of the International Organizations Immunities Act (22... public international organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2...

26 CFR 31.3121(b)(15)-1 - Services in employ of international organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... organization. (a) Subject to the provisions of section 1 of the International Organizations Immunities Act (22... public international organization entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2...

An active Mitochondrial Complex II Present in Mature Seeds Contains an Embryo-Specific Iron-Sulfur Subunit Regulated by ABA and bZIP53 and Is Involved in Germination and Seedling Establishment.

PubMed

Restovic, Franko; Espinoza-Corral, Roberto; Gómez, Isabel; Vicente-Carbajosa, Jesús; Jordana, Xavier

2017-01-01

Complex II (succinate dehydrogenase) is an essential mitochondrial enzyme involved in both the tricarboxylic acid cycle and the respiratory chain. In Arabidopsis thaliana , its iron-sulfur subunit (SDH2) is encoded by three genes, one of them ( SDH2.3 ) being specifically expressed during seed maturation in the embryo. Here we show that seed SDH2.3 expression is regulated by abscisic acid (ABA) and we define the promoter region (-114 to +49) possessing all the cis -elements necessary and sufficient for high expression in seeds. This region includes between -114 and -32 three ABRE (ABA-responsive) elements and one RY-enhancer like element, and we demonstrate that these elements, although necessary, are not sufficient for seed expression, our results supporting a role for the region encoding the 5' untranslated region (+1 to +49). The SDH2.3 promoter is activated in leaf protoplasts by heterodimers between the basic leucine zipper transcription factors bZIP53 (group S1) and bZIP10 (group C) acting through the ABRE elements, and by the B3 domain transcription factor ABA insensitive 3 (ABI3). The in vivo role of bZIP53 is further supported by decreased SDH2.3 expression in a knockdown bzip53 mutant. By using the protein synthesis inhibitor cycloheximide and sdh2 mutants we have been able to conclusively show that complex II is already present in mature embryos before imbibition, and contains mainly SDH2.3 as iron-sulfur subunit. This complex plays a role during seed germination sensu-stricto since we have previously shown that seeds lacking SDH2.3 show retarded germination and now we demonstrate that low concentrations of thenoyltrifluoroacetone, a complex II inhibitor, also delay germination. Furthermore, complex II inhibitors completely block hypocotyl elongation in the dark and seedling establishment in the light, highlighting an essential role of complex II in the acquisition of photosynthetic competence and the transition from heterotrophy to autotrophy.

Discovery of rare, diagnostic AluYb8/9 elements in diverse human populations.

PubMed

Feusier, Julie; Witherspoon, David J; Scott Watkins, W; Goubert, Clément; Sasani, Thomas A; Jorde, Lynn B

2017-01-01

Polymorphic human Alu elements are excellent tools for assessing population structure, and new retrotransposition events can contribute to disease. Next-generation sequencing has greatly increased the potential to discover Alu elements in human populations, and various sequencing and bioinformatics methods have been designed to tackle the problem of detecting these highly repetitive elements. However, current techniques for Alu discovery may miss rare, polymorphic Alu elements. Combining multiple discovery approaches may provide a better profile of the polymorphic Alu mobilome. Alu Yb8/9 elements have been a focus of our recent studies as they are young subfamilies (~2.3 million years old) that contribute ~30% of recent polymorphic Alu retrotransposition events. Here, we update our ME-Scan methods for detecting Alu elements and apply these methods to discover new insertions in a large set of individuals with diverse ancestral backgrounds. We identified 5,288 putative Alu insertion events, including several hundred novel Alu Yb8/9 elements from 213 individuals from 18 diverse human populations. Hundreds of these loci were specific to continental populations, and 23 non-reference population-specific loci were validated by PCR. We provide high-quality sequence information for 68 rare Alu Yb8/9 elements, of which 11 have hallmarks of an active source element. Our subfamily distribution of rare Alu Yb8/9 elements is consistent with previous datasets, and may be representative of rare loci. We also find that while ME-Scan and low-coverage, whole-genome sequencing (WGS) detect different Alu elements in 41 1000 Genomes individuals, the two methods yield similar population structure results. Current in-silico methods for Alu discovery may miss rare, polymorphic Alu elements. Therefore, using multiple techniques can provide a more accurate profile of Alu elements in individuals and populations. We improved our false-negative rate as an indicator of sample quality for future ME-Scan experiments. In conclusion, we demonstrate that ME-Scan is a good supplement for next-generation sequencing methods and is well-suited for population-level analyses.

Evaluation of the Impact of Kerojet (trademark) Aquarius Water Scavenger Additive on the Thermal Stability of Jet A Fuels

DTIC Science & Technology

2014-12-01

113 Figure 64 - Elemental Analysis, Typical TMS Post - Test , Post Carbon Burn-off, Hexane rinsed ............ 114 Figure 65 – SEM (20X...Agency’s Wright-Patterson Aerospace Fuels Laboratory AFRL Air Force Research Laboratory AFTSTU Aviation Fuel Thermal Stability Test Unit ARSFSS Advanced...Approved for public release; distribution unlimited. For all ARSFSS testing , SV hysteresis is measure pre- and post - test and is defined by relating

Pulsed power accelerator for material physics experiments

DOE PAGES

Reisman, D.  B.; Stoltzfus, B.  S.; Stygar, W.  A.; ...

2015-09-01

We have developed the design of Thor: a pulsed power accelerator that delivers a precisely shaped current pulse with a peak value as high as 7 MA to a strip-line load. The peak magnetic pressure achieved within a 1-cm-wide load is as high as 100 GPa. Thor is powered by as many as 288 decoupled and transit-time isolated bricks. Each brick consists of a single switch and two capacitors connected electrically in series. The bricks can be individually triggered to achieve a high degree of current pulse tailoring. Because the accelerator is impedance matched throughout, capacitor energy is delivered tomore » the strip-line load with an efficiency as high as 50%. We used an iterative finite element method (FEM), circuit, and magnetohydrodynamic simulations to develop an optimized accelerator design. When powered by 96 bricks, Thor delivers as much as 4.1 MA to a load, and achieves peak magnetic pressures as high as 65 GPa. When powered by 288 bricks, Thor delivers as much as 6.9 MA to a load, and achieves magnetic pressures as high as 170 GPa. We have developed an algebraic calculational procedure that uses the single brick basis function to determine the brick-triggering sequence necessary to generate a highly tailored current pulse time history for shockless loading of samples. Thor will drive a wide variety of magnetically driven shockless ramp compression, shockless flyer plate, shock-ramp, equation of state, material strength, phase transition, and other advanced material physics experiments.« less

Mars at Ls 288°: Syrtis Major

NASA Image and Video Library

2005-09-21

This picture, released 21 September 2005, is a composite of Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) daily global images acquired at Ls 288° during a previous Mars year. This month, Mars looks similar, as Ls 288° occurred in mid-September 2005. The picture shows the Syrtis Major face of Mars. Over the course of the month, additional faces of Mars as it appears at this time of year are being posted for MOC Picture of the Day. Ls, solar longitude, are a measure of the time of year on Mars. Mars travels 360° around the Sun in 1 Mars year. The year begins at Ls 0°, the start of northern spring and southern autumn.

Cadmium, zinc, copper, sodium and potassium concentrations in rooster and turkey semen and their correlation.

PubMed

Massanyi, Peter; Weis, Jan; Lukac, Norbert; Trandzik, Jozef; Bystricka, Judita

2008-04-01

The purpose of this study was to assess concentration of selected elements (cadmium, zinc, copper, sodium and potassium) in rooster and turkey semen and to find possible correlations between these elements. Samples were analyzed on the atomic absorption spectrophotometer. The analysis of cadmium showed that the concentration in rooster is 9.06 +/- 7.70 and in turkey 4.10 +/- 3.59 microg/mL. In zinc 5.25 +/- 1.96 microg/mL in rooster and 3.70 +/- 1.26 microg/mL in turkey were detected. Higher concentration of copper was found in rooster semen (6.79 +/- 6.42 microg/mL) in comparison with turkey semen (4.29 +/- 5.43 microg/mL). The level of sodium (3.96 +/- 1.02 microg/mL; 3.14 +/- 0.85 microg/mL) and potassium (2.88 +/- 0.65 microg/mL; 3.42 +/- 1.41 microg/mL) was very similar in both species. Correlation analysis detected high positive correlation between cadmium and zinc (r = 0.701) in rooster and between sodium and potassium (r = 0.899) in turkey semen.

Experiments on the Synthesis of Superheavy Elements with 48CA Beams at the Separator Vassilissa

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Yeremin, A. V.; Belozerov, A. V.; Chelnokov, M. L.; Chepigin, V. I.; Gorshkov, V. A.; Kabachenko, A. P.; Korotkov, S. P.; Malyshev, O. N.; Popeko, A. G.; Roháč, J.; Sagaidak, R. N.; Hofmann, S.; Münzenberg, G.; Veselsky, M.; Saro, S.; Iwasa, N.; Morita, K.; Giardina, G.

2001-04-01

The study of the decay properties and formation cross sections of the isotopes of elements 110, 112 and 114 were performed at the FLNR JINR with the use of the high intensity 48Ca beams and an electrostatic separator VASSILISSA. 232Th, 238U and 242Pu targets were used in the experiments. At the beam energies corresponding to the calculated cross section maxima of the 3n evaporation channels the isotopes 277110, 283112 and 287114 were produced and identified. The cross section limits were obtained at excitation energies of the compound nucleus corresponding to the maxima of the 4n evaporation channels for the reactions with 232Th and 238U targets.

26 CFR 31.3306(c)(16)-1 - Services in employ of international organization.

Code of Federal Regulations, 2012 CFR

2012-04-01

... provisions of section 1 of the International Organizations Immunities Act (22 U.S.C. 228), services performed... entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2) Section 1 of the International...

26 CFR 31.3306(c)(16)-1 - Services in employ of international organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... provisions of section 1 of the International Organizations Immunities Act (22 U.S.C. 228), services performed... entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2) Section 1 of the International...

26 CFR 31.3306(c)(16)-1 - Services in employ of international organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... provisions of section 1 of the International Organizations Immunities Act (22 U.S.C. 228), services performed... entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2) Section 1 of the International...

26 CFR 31.3306(c)(16)-1 - Services in employ of international organization.

Code of Federal Regulations, 2014 CFR

2014-04-01

... provisions of section 1 of the International Organizations Immunities Act (22 U.S.C. 228), services performed... entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2) Section 1 of the International...

26 CFR 31.3306(c)(16)-1 - Services in employ of international organization.

Code of Federal Regulations, 2013 CFR

2013-04-01

... provisions of section 1 of the International Organizations Immunities Act (22 U.S.C. 228), services performed... entitled to enjoy privileges, exemptions, and immunities as an international organization under the International Organizations Immunities Act (22 U.S.C. 288-288f). (2) Section 1 of the International...

[Analysis of community composition in dental plaque of elder people with root caries].

PubMed

Ma, Shan-fen; Liang, Jing-ping; Jiang, Yun-tao; Zhu, Cai-lian

2011-10-01

To analyze the community in dental plaque of elder people with root caries. Total DNAs were extracted from the root caries dental plaques of nine elders over 60 years of age. Polymerase chaid reaction-based denaturing gradient gel electrophoresis (PCR-DGGE) was used to analyze the microbial composition, DGGE bands were excised from the gels for sequencing and identification. The dominant genus in root caries dental plaque of elder people were: Acinetobacte [0.9% (1/114)], Actinobaculum [1.8% (2/114)], Actinomyces [15.8% (18/114)], Aggregatibacter [0.9% (1/114)], Capnocytophaga [14.0% (16/114)], Corynebacterium [0.9% (1/114)], Haemophilus [0.9% (1/114)], Mobiluncus [0.9% (1/114)], Naxibacter [0.9% (1/114)], Neisseriaceae [10.5% (12/114)], Porphyromonas [0.9% (1/114)], Prevotella [12.3% (14/114)], Selenomonas [6.1% (7/114)], Staphylococcus [1.8% (2/114)], Oralis streptococcus [6.1% (7/114)], Mutans streptococcu [7.9% (9/114)], Tannerella [0.9% (1/114)], Treponema [1.8% (2/114)], Veillonella [10.5% (12/114)] and two uncultured unknown genus [1.8% (2/114)]. Uncultred genotypes accounted for 19.30% of the total. Gram-positive bacteria genotype accounted for 31.6% (36/114), and Gram-negative bacteria genotype accounted for 66.7% (76/114). There were many bacteria genotypes in root caries dental plaque in the elderly, which were widely distributed. Gram-negative bacteria accounted for the majority. Genotype-specific pathogenic bacteria were not found.

Luminescence properties of ZnxMg1-xSe layers

NASA Astrophysics Data System (ADS)

Bala, Waclaw; Firszt, Franciszek; Dzik, Janusz; Gapinski, Adam; Glowacki, Grzegorz

1995-10-01

This work deals with the study of luminescence properties of ZnxMg1-xSe layers prepared by different methods. ZnxMg1-xSe mixed crystal layers were obtained by: (a) thermal diffusion of Mg metal in the temperature range 1050 K - 1200 K into ZnSe single crystal grown by Bridgman method, and (b) epitaxial growth on (001) GaAs and (111) ZnTe substrates by MBE using elemental Zn, Se and Mg sources. The luminescence spectra of ZnxMg1-xSe layers grown on (001) GaAs and (111) ZnTe substrates are dominated by narrow blue and violet emission bands with maxima positioned at about 3.05 - 3.28 eV, 2.88 - 3.04 eV, and 2.81 - 2.705 eV.

Power Controller 28VDC Load Switching (N.O. SPST).

DTIC Science & Technology

1980-01-21

34111111CATION0 TS PAGE (W~ Ow at~ eal________________ REPORT DOCUMENTATION PAGE ______________aINGFORK 1 . REPORT HM1119ER 12. Govt ACCESSION NO: L...ackin N 62269-77-C-0413 1 9. 109111ORMrNG ORGANIZATION NAME AMCO AOORESS 10-O PROGRAM ELEMENT. PROJECT. TASK Govenmen Comuniatio SysemsARA A WORK UNIT...DATE Naval Air Development center (AVTD-P) 21 January1980 Iwarminster, Pennsylvania 18974I&HM114OiPA9 1 ,L WMNITORINO AGENCY MNMG ADDRESS4I dfeel aeet

The Human Element in Space: Lessons from Antarctica

DTIC Science & Technology

1988-02-10

misunderstandings and conflicts between space traveler and ground support personnel ( Kubis , 1972; Oberg, 1981). In the Antarctic, levels of depressive...biomedical opportunities in space. New Engl J Med 315: 1196-1200. 19 - .•__r• w • ,# •. • L • -- • l•- ••.- . •- 1 1111-1_114• • Kubis , J.F. (1972) isolation...325 Nardini, 3.E,, Herrmann, R.S., and Rasmussen, J.E, (1962) Navy psychiatric assessment in the Antarctic. Am 3 Psychiatry 119s 97-105. Natani, K

Thermophysical Properties of Matter - The TPRC Data Series. Volume 4. Specific Heat - Metallic Elements and Alloys

DTIC Science & Technology

1971-01-01

alloys— sodium — sodium alloya— solder—carbon ateels—chromium steels—silicon steels—tantalum—tantalum alloys—terbium—thallium—thallium alloys—thorium...Praseodymium 45 Rhenium 46 Rhodium 47 Rubidium 48 Ruthenium 4» Samarium 50 Scandium 51 Selenium 52 Silicon 5:i Silver 54 Sodium 55 Strontium 56...Potassium ♦ Sodium 111 Sodium * Potassium 112 Tantalum ♦ Tungsten 113 Thallium + Lead, PbTl| 114 Tin ♦ Bismuth 115 Tin ♦ Indium 116 Tin+ Lead 117

Minnesota Water Allocation Law. Volume 1. Commentary on and Abstracts of Treaties, Legislation and Rules.

DTIC Science & Technology

1987-09-01

If applicable) 8c. ADDRESS(City, State, and ZIP Code) 10. SOURCE OF FUNDING NUMBERS ELEMENT NO. NO. NO ACCESSION NO .T 11 TITLE (Include Security...Indians 1-13 Domestic Water Supply on Reservations 1-14 Ground water sources 1-16 Surface water sources 1-16 Commentary on Indian Water Resources 1-17...General’s Office - St. Paul, Minnesota 4 DATA COLLECTION AND REPORT ORGANIZATION Data collected for these volumes result from three primary sources

Modern physics - Guest editorial

NASA Astrophysics Data System (ADS)

Howes, Ruth

2000-02-01

What an exciting time to be a physicist! You only have to attend the plenaries at an AAPT meeting to realize just how many mysteries there still are. Will string theory actually prove to be a Theory of Everything? Can we use physics to understand, predict, and perhaps eventually mitigate damaging hurricanes? Is the warming trend of the Earth due to man-made changes in the atmosphere? Have we found the nuclear "island of stability" with elements 114, 116, and 118? For that matter, why is ice slippery?

Fighting the Global War on Terror Tolerably: Augmenting the Global Counter Insurgency Strategy with Surrogates

DTIC Science & Technology

2007-03-27

186, 198 36 their cattle .114 It was left to the BATT to determine how to overcome these predicaments; from forgoing the element of surprise and...demonstrating the CAS to planning and executing what might be the first cattle drive to be conducted with CAS and artillery providing security. For all...demonstrated that the Firqat were not pawns of the British. The relegation of the Harkis to a constant subordinate role effectively castrated them in the

Host Materials for Transition-Metal Ions

DTIC Science & Technology

1989-09-01

Spectra of 3d Transition Elements in KMgF3 Crystal, Soy. Phys. Solid State 19 (1977), 340. 21. H . Onuki , F. Sugawara, M. Hirano, and Y. Yamaguchi...on Cs2SnBr 6 .... h ............. 84 13.2 Crystal-Field Components, Anm, for Sn (Oh) Site .............. 814 13.3 Experimental Parameters...A.M VSg Kleef, Y. N. .3oshi, and R. P. Srivastava, Analysis of’ Cd V: I.--4Ida-id’ 5p Transitions, Physica 114IC (1982), 105. 15. H . Benschop, Y. N

Self-purification of agrosoddy-podzolic sandy loamy soils fertilized with sewage sludge

NASA Astrophysics Data System (ADS)

Plekhanova, I. O.

2017-04-01

Sandy loamy agrosoddy-podzolic soils and plants growing on them were studied. The soils had been treated with sewage sludge from the Lyubertsy aeration station applied as organic fertilizer for 5-10 years before 1990. Initially, these soils were used for cultivating vegetables and fodder crops. The content and mobility of heavy metal compounds increased in the plow horizons of studied soils under the influence of sewage sludge. The concentrations of Cd and Zn exceeded the tentative permissible concentrations (TPC) for these elements by 8-16 and 2-4 times, respectively. The contaminated layer was found at the depths within 30-50 cm, which attests to a low migration rate of heavy metals added to the studied soils with sewage sludge (SS) 25 years ago. The concentration of Cd exceeded the maximum permissible concentration (MPC) of this element in all vegetable and fodder crops cultivated on the studied soils. The content of heavy metals in plants differed by three-five times in dependence on the capacity of particular plants to accumulate them. The period of soil self-purification from heavy metals was found to depend on the soil contamination level and element mobility, as well as on the element removal with harvested crops and with soil water flows. The maximal time of achieving the normal level of Cd concentration was estimated as 288 years for maximally contaminated soils; the corresponding values for Cu and Zn were estimated as 74 and 64 years, respectively.

The refractive index of krypton for lambda in the closed interval 168-288 nm

NASA Technical Reports Server (NTRS)

Smith, P. L.; Parkinson, W. H.; Huber, M. C. E.

1975-01-01

The index of refraction of krypton has been measured at 27 wavelengths between and including 168 and 288 nm. The probable error of each measurement is plus or minus 0.1%. Our results are compared with other measurements. Our data are about 3.8% smaller than those of Abjean et al.

Ureaplasma serotypes associated with the bovine urogenital tract.

PubMed Central

Truscott, R B

1983-01-01

One hundred and thirty-one ureaplasma isolates were tested using the immunoperoxidase system. Thirty-four were from semen, 34 from preputial washes of normal bulls and 63 were from vaginal swabs from herds experiencing infertility problems and/or vulvovaginitis. The serotypes from semen were T44 (12.1%), Bu2 (11.2%), D48 (2.8%), T315 (0.9%) and T288 (0.9%). Those from preputial washes were T44 (9.3%), Bu2 (8.4%), T288 (7.5%), D48 (0.9%) and T95 (0.9%). From vaginal swabs the serotypes were D48 (22.4%), Bu2 (10.3%), T45 (4.7%), T288 (3.8%) and T315 (1.9%). PMID:6365295

21 CFR 114.5 - Current good manufacturing practice.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Current good manufacturing practice. 114.5 Section...) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS General Provisions § 114.5 Current good manufacturing practice. The criteria in §§ 114.10, 114.80, 114.83, 114.89, and 114.100, as well as the criteria in part...

Seasonal determination of trace and ultra-trace content in Macrocystis pyrifera from San Jorge Gulf (Patagonia) by Total Reflection X-ray Fluorescence

NASA Astrophysics Data System (ADS)

Salomone, Vanesa N.; Riera, Marina; Cerchietti, Luciana; Custo, Graciela; Muniain, Claudia

2017-05-01

Seaweed have a great capacity to accumulate heavy metals in their tissues. The chemical characterization of seaweed is important due to their use in environmental monitoring and human or animal food. The aim of the present study was to evaluate the multi-elemental composition of seaweed from San Jorge Gulf (Patagonia, Argentina) by Total Reflection X-ray Fluorescence (TXRF). The elements As, Br, Cu, Cr, Fe, Mn, Ni, Pb, Rb, Sr, V and Zn were seasonally analyzed and quantified in blades of Macrocystis pyrifera. TXRF showed to be a suitable technique for simultaneous multi-element analysis in this kind of samples. The results revealed seasonal variations in the chemical content for some elements; arsenic content was maximum in summer and autumn, iron concentration increased to the winter and zinc concentration was maximum in autumn. The sum of principal micronutrients (Fe + Zn + Mn + Cu) varied between 114 and 171 mg k- 1 g dw. The total As concentration ranged between 36 and 66 mg kg- 1. Lead, nickel and copper were not detected.

Two contrasting late Paleozoic magmatic episodes in the northwestern Chinese Tianshan Belt, NW China: Implication for tectonic transition from plate convergence to intra-plate adjustment during accretionary orogenesis

NASA Astrophysics Data System (ADS)

Wang, Xiangsong; Cai, Keda; Sun, Min; Xiao, Wenjiao; Xia, Xiaoping; Wan, Bo; Bao, Zihe; Wang, Yannan

2018-03-01

Late Carboniferous to Early Permian is a critical period for the final amalgamation of the Central Asian Orogenic Belt (CAOB). However, as most of the accreted terranes of the CAOB are unclear in tectonic nature and origin, the timing and processes of their mutual amalgamation have been poorly constrained. To understand assembly of the West Junggar Terrane with the Yili Block, a suite of the late Paleozoic magmatic rocks, including ignimbrite, rhyolite and granite, in northwestern Chinese Tianshan Belt were studied for their petrogenesis and tectonic implications. Our new results of secondary ion mass spectrometry (SIMS) zircon U-Pb dating reveal two separate magmatic episodes, ca. 300 Ma volcanism (ignimbrite and rhyolite) and ca. 288 Ma plutonsim (biotite granite). Geochemically, for the ca. 300 Ma volcanism, the ignimbrites have low SiO2 (65.8-71.5 wt.%) and Mg# (6-13) values, and exhibit arc affinity with significantly enriched in large ion lithophile elements (LILE) and depleted in high field strength elements (HFSE) such as Nb, Ta and Ti. The whole-rock εNd(t) and zircon εHf(t) values range from +6.9 to +7.0 and +9.9 to +14.1 respectively, indicating a juvenile basaltic lower crustal origin. Rhyolites have slightly high SiO2 (72.7-74.0 wt.%) and K2O (3.86-4.53 wt.%) contents, high zircon δ18O (11.67-13.23‰) values, and low whole-rock εNd(t) (+2.9 to +3.8) and zircon εHf(t) (+2.8 to +10.0) values, which may suggest sediment involvements during magma generation. In contrast, for the ca. 288 Ma plutonism, the biotite granites have obviously higher SiO2 (74.7-75.5 wt.%) contents and whole-rock εNd(t) (+7.7 to +8.8), zircon εHf(t) (+9.8 to +12.7), and lower zircon δ18O (5.99-6.84‰) values, than those of the ca. 300 Ma volcanic rocks, which are consistent with signatures of juvenile magma source. According to our estimates of zircon saturation temperatures, together with their contrasting genesis, we attribute the formation of ca. 300 Ma high temperature (815-938 °C) volcanism to oceanic slab break-off during assembly of the West Junggar Terrane with the Yili Block, and relate the generation of ca. 288 Ma low temperature (723-735 °C) plutonism to subsequent strike-slipping of North Tianshan Fault that facilitated introduction of water-fluxes triggering hydrous partial melting of juvenile lower crust. The sequential magmatic episodes in the northwestern Chinese Tianshan Belt may provide a crucial clue to a tectonic transition from plate convergence to intra-plate adjustment during the formation of the Kazakhstan Orocline in the late Paleozoic.

30 CFR 250.288 - When and how must I submit the Conceptual Plan?

Code of Federal Regulations, 2010 CFR

2010-07-01

... OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Deepwater Operations Plans (dwop) § 250.288 When and how must I submit the Conceptual Plan? You must submit four copies... 30 Mineral Resources 2 2010-07-01 2010-07-01 false When and how must I submit the Conceptual Plan...

A novel construction scheme of QC-LDPC codes based on the RU algorithm for optical transmission systems

NASA Astrophysics Data System (ADS)

Yuan, Jian-guo; Liang, Meng-qi; Wang, Yong; Lin, Jin-zhao; Pang, Yu

2016-03-01

A novel lower-complexity construction scheme of quasi-cyclic low-density parity-check (QC-LDPC) codes for optical transmission systems is proposed based on the structure of the parity-check matrix for the Richardson-Urbanke (RU) algorithm. Furthermore, a novel irregular QC-LDPC(4 288, 4 020) code with high code-rate of 0.937 is constructed by this novel construction scheme. The simulation analyses show that the net coding gain ( NCG) of the novel irregular QC-LDPC(4 288,4 020) code is respectively 2.08 dB, 1.25 dB and 0.29 dB more than those of the classic RS(255, 239) code, the LDPC(32 640, 30 592) code and the irregular QC-LDPC(3 843, 3 603) code at the bit error rate ( BER) of 10-6. The irregular QC-LDPC(4 288, 4 020) code has the lower encoding/decoding complexity compared with the LDPC(32 640, 30 592) code and the irregular QC-LDPC(3 843, 3 603) code. The proposed novel QC-LDPC(4 288, 4 020) code can be more suitable for the increasing development requirements of high-speed optical transmission systems.

Collective properties of low-lying octupole excitations in 20882Pb126, 6020Ca40 and 288O20

NASA Astrophysics Data System (ADS)

Zhou, X. R.; Zhao, E. G.; Dong, B. G.; Zhang, X. Z.; Long, G. L.

2003-08-01

The octupole strengths of three nuclei: β-stable nucleus 20882Pb 126, neutron skin nucleus 6020Ca 40 and neutron drip line nucleus 288O 20 are studied by using the self-consistent Hartree-Fock calculation with the random phase approximation. The collective properties of low-lying excitations are analyzed by particle-vibration coupling. The results show that there is the coexistence of the collective excitations and the decoupled strong continuum strength near the threshold in the lowest isoscalar states in 6020Ca 40 and 288O 20. For these three nuclei, both the low-lying isoscalar states and giant isoscalar resonance carry isovector strength. The ratio B(IV)/ B(IS) is checked and it is found that, for 20882Pb 126, the ratio is equal to (( N- Z)/ A) 2 in good accuracy, while for 6020Ca 40 and 288O 20, the ratios are much larger than (( N- Z)/ A) 2. The study shows that the enhancement of the ratio is due to the excess neutrons that have small binding energies in 6020Ca 40 and 288O 20.

Advanced age and incidence of atrial fibrillation in the postoperative period of aortic valve replacement

PubMed Central

Pivatto Júnior, Fernando; Teixeira Filho, Guaracy Fernandes; Sant'anna, João Ricardo Michelin; Py, Pablo Mondim; Prates, Paulo Roberto; Nesralla, Ivo Abrahão; Kalil, Renato Abdala Karam

2014-01-01

Objective This study aims to describe the correlation between age and occurrence of atrial fibrillation after aortic stenosis surgery in the elderly as well as evaluate the influence of atrial fibrillation on the incidence of strokes, hospital length of stay, and hospital mortality. Methods Cross-sectional retrospective study of > 70 year-old patients who underwent isolated aortic valve replacement. Results 348 patients were included in the study (mean age 76.8±4.6 years). Overall, post-operative atrial fibrillation was 32.8% (n=114), but it was higher in patients aged 80 years and older (42.9% versus 28.8% in patients aged 70-79 years, P=0.017). There was borderline significance for linear correlation between age and atrial fibrillation (P=0.055). Intensive Care Unit and hospital lengths of stay were significantly increased in atrial fibrillation (P<0.001), but there was no increase in mortality or stroke associated with atrial fibrillation. Conclusion Post-operative atrial fibrillation incidence in aortic valve replacement is high and correlates with age in patients aged 70 years and older and significantly more pronounced in patients aged 80 years. There was increased length of stay at Intensive Care Unit and hospital, but there was no increase in mortality or stroke. These data are important for planning prophylaxis and early treatment for this subgroup. PMID:24896162

Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis

PubMed Central

Ng, Jia Lin; Ong, Whee Sze; Chia, Claramae Shulyn; Tan, Grace Hwei Ching; Soo, Khee-Chee; Teo, Melissa Ching Ching

2016-01-01

Background. Peritoneal Carcinomatosis Index (PCI) is a widely established scoring system that describes disease burden in isolated colorectal peritoneal carcinomatosis (CPC). Its significance may be diminished with complete cytoreduction. We explore the utility of the recently described Peritoneal Surface Disease Severity Score (PSDSS) and compare its prognostic value against PCI. Methods. The endpoints were overall survival (OS), progression-free survival (PFS), and survival less than 18 months (18 MS). Results. Fifty patients underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for CPC from 2003 to 2014, with 98% achieving complete cytoreduction. Median OS was 28.8 months (95% CI, 18.0–39.1); median PFS was 9.4 months (95% CI, 7.7–13.9). Univariate analysis showed that higher PCI was significantly associated with poorer OS (HR 1.11; 95% CI, 1.03–1.20) and PFS (HR 1.09; 95% CI, 1.03–1.14). Conversely, PSDSS was not associated with either endpoint. Multivariate analysis showed that PCI, but not PSDSS, was predictive of OS and PFS. PCI was also able to discriminate survival outcomes better than PSDSS for both OS and PFS. There was no association between 18 MS and either score. Conclusion. PCI is superior to PSDSS in predicting OS and PFS and remains the prognostic score of choice in CPC patients undergoing CRS/HIPEC. PMID:27006828

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), points to data on the console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), points to data on the console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), stands inside the Japanese Experiment Module (JEM) that is undergoing a Multi-Element Integrated Test (MEIT) with the U.S. Node 2. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), stands inside the Japanese Experiment Module (JEM) that is undergoing a Multi-Element Integrated Test (MEIT) with the U.S. Node 2. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (left), with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM) in the Space Station Processing Facility. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 provides attach locations for the Japanese laboratory, as well as European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. Installation of the module will complete the U.S. Core of the ISS.

Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods.

PubMed

Lin, Tong; Liu, Tiebing; Lin, Yucheng; Yan, Lailai; Chen, Zhongxue; Wang, Jingyu

2017-09-01

The etiology and pathophysiology of schizophrenia (SCZ) remain obscure. This study explored the associations between SCZ risk and serum levels of 39 macro and trace elements (MTE). A 1:1 matched case-control study was conducted among 114 schizophrenia patients and 114 healthy controls matched by age, sex and region. Blood samples were collected to determine the concentrations of 39 MTE by ICP-AES and ICP-MS. Both supervised learning methods and classical statistical testing were used to uncover the difference of MTE levels between cases and controls. The best prediction accuracies were 99.21% achieved by support vector machines in the original feature space (without dimensionality reduction), and 98.82% achieved by Naive Bayes with dimensionality reduction. More than half of MTE were found to be significantly different between SCZ patients and the controls. The presented investigation showed that there existed remarkable differences in concentrations of MTE between SCZ patients and healthy controls. The results of this study might be useful to diagnosis and prognosis of SCZ; they also indicated other promising applications in pharmacy and nutrition. However, the results should be interpreted with caution due to limited sample size and the lack of potential confounding factors, such as alcohol, smoking, body mass index (BMI), use of antipsychotics and dietary intakes. In the future the application of the analyses will be useful in designs that have larger sample sizes. Copyright © 2017 Elsevier GmbH. All rights reserved.

Mars at Ls 288o: Acidalia/Mare Erythraeum

NASA Technical Reports Server (NTRS)

2005-01-01

13 September 2005 This picture is a composite of Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) daily global images acquired at Ls 288o during a previous Mars year. This month, Mars looks similar, as Ls 288o occurs in mid-September 2005. The picture shows the Acidalia/Mare Erythraeum face of Mars. Over the course of the month, additional faces of Mars as it appears at this time of year are being posted for MOC Picture of the Day. Ls, solar longitude, is a measure of the time of year on Mars. Mars travels 360o around the Sun in 1 Mars year. The year begins at Ls 0o, the start of northern spring and southern autumn.

Season: Northern Winter/Southern Summer

Mars at Ls 288o: Elysium/Mare Cimmerium

NASA Technical Reports Server (NTRS)

2005-01-01

27 September 2005 This picture is a composite of Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) daily global images acquired at Ls 288o during a previous Mars year. This month, Mars looks similar, as Ls 288o occurred in mid-September 2005. The picture shows the Elysium/Mare Cimmerium face of Mars. Over the course of the month, additional faces of Mars as it appears at this time of year are being posted for MOC Picture of the Day. Ls, solar longitude, is a measure of the time of year on Mars. Mars travels 360o around the Sun in 1 Mars year. The year begins at Ls 0o, the start of northern spring and southern autumn.

Season: Northern Winter/Southern Summer

What do the trace metal contents of urine and toenail samples from Qatar׳s farm workers bioindicate?

PubMed

Kuiper, Nora; Rowell, Candace; Nriagu, Jerome; Shomar, Basem

2014-05-01

Qatar׳s farm workers provide a unique population for exposure study: they are young, healthy males. This study combined trace element profiles in urine and toenail with survey information from 239 farm workers to assess the extent to which the biomarkers provide complementary exposure information. Urinary Mo levels (average=114 µg/L) were elevated; average urinary values (µg/L) for all other elements were: V (1.02), Cr (0.55), Mn (2.15), Fe (34.1), Co (0.47), Ni (2.95), Cu (15.0), As (47.8), Se (25.7), Cd (1.09), Ba (22.5), Pb (2.50) and U (0.15). Average toenail concentrations (mg/kg) were: Mn (2.48), Cu (4.43), As (0.26), Se (0.58), Mo (0.07), Cd (0.03), Ba (1.00), Pb (0.51) and U (0.02). No significant association was found between corresponding elements in urine and toenails. Elemental profiles suggest groundwater (with the exception of Mo) and soil-dust-crop exposure pathways cannot account for elemental variations. The main factors moderating trace element contents are related to depuration processes involving participants׳ trace element body burden prior to work in Qatar, and interactions of trace element metabolic cycles which over-ride the exposure footprint. Toenail and urine need to be carefully validated before reliable use as biomarkers of exposure in general populations for most elements in the study. Copyright © 2014 Elsevier Inc. All rights reserved.

LBT/MODS spectroscopy of globular clusters in the irregular galaxy NGC 4449

NASA Astrophysics Data System (ADS)

Annibali, F.; Morandi, E.; Watkins, L. L.; Tosi, M.; Aloisi, A.; Buzzoni, A.; Cusano, F.; Fumana, M.; Marchetti, A.; Mignoli, M.; Mucciarelli, A.; Romano, D.; van der Marel, R. P.

2018-05-01

We present intermediate-resolution (R ˜ 1000) spectra in the ˜3500-10 000 Å range of 14 globular clusters in the Magellanic irregular galaxy NGC 4449 acquired with the Multi-Object Double Spectrograph on the Large Binocular Telescope. We derived Lick indices in the optical and the Ca II triplet index in the near-infrared in order to infer the clusters' stellar population properties. The inferred cluster ages are typically older than ˜9 Gyr, although ages are derived with large uncertainties. The clusters exhibit intermediate metallicities, in the range -1.2 ≲ [Fe/H] ≲ -0.7, and typically sub-solar [α/Fe] ratios, with a peak at ˜-0.4. These properties suggest that (i) during the first few Gyr NGC 4449 formed stars slowly and inefficiently, with galactic winds having possibly contributed to the expulsion of the α-elements, and (ii) globular clusters in NGC 4449 formed relatively `late', from a medium already enriched in the products of Type Ia supernovae. The majority of clusters appear also underabundant in CN compared to Milky Way halo globular clusters, perhaps because of the lack of a conspicuous N-enriched, second generation of stars like that observed in Galactic globular clusters. Using the cluster velocities, we infer the dynamical mass of NGC 4449 inside 2.88 kpc to be M(<2.88 kpc) = 3.15^{+3.16}_{-0.75} × 10^9 M_{\\odot }. We also report the serendipitous discovery of a planetary nebula within one of the targeted clusters, a rather rare event.

Extended HSR/CARD domain mediates AIRE binding to DNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maslovskaja, Julia, E-mail: julia.maslovskaja@ut.ee; Saare, Mario; Liiv, Ingrid

Autoimmune regulator (AIRE) activates the transcription of many genes in an unusual promiscuous and stochastic manner. The mechanism by which AIRE binds to the chromatin and DNA is not fully understood, and the regulatory elements that AIRE target genes possess are not delineated. In the current study, we demonstrate that AIRE activates the expression of transiently transfected luciferase reporters that lack defined promoter regions, as well as intron and poly(A) signal sequences. Our protein-DNA interaction experiments with mutated AIRE reveal that the intact homogeneously staining region/caspase recruitment domain (HSR/CARD) and amino acids R113 and K114 are key elements involved inmore » AIRE binding to DNA. - Highlights: • Promoter and mRNA processing elements are not important for AIRE to activate gene expression from reporter plasmids. • AIRE protein fragment aa 1–138 mediates direct binding to DNA. • Integrity of the HSR/CARD domain is needed for AIRE binding to DNA.« less

A pure inorganic 1D chain based on {Mo8O28} clusters and Mn(II) ions: [Mn(H2O)2Mo8O28 ] n 6 n -

NASA Astrophysics Data System (ADS)

Zhang, Xiaofen; Yan, Yonghong; Wu, Lizhou; Yu, Chengxin; Dong, Xinbo; Hu, Huaiming; Xue, Ganglin

2016-01-01

A new pure inorganic polymer, (NH4)6n[Mn(H2O)2Mo8O28)]n(H2O)2n(1), has been synthesized and characterized by elemental analyses, IR spectrum, UV-vis absorption spectra, TG-DSC and electrochemical studies. In 1, [Mo8O28]8- anions act as tetradentate ligands and are alternately linked by Mn(H2O)2 2 + ions into a one-dimensional chain structure. It is interesting that 1 represents the first example of pure inorganic-inorganic hybrid based on octamolybdate and transition metal ions. Moreover, it was indicated that 1 had definite catalytic activities on the probe reaction of benzyl alcohol oxidation to benzaldehyde with H2O2.

Synthesis and characterization of 3-ketohexadecanoic acid-1-14-C, DL-3-hydroxyhexadecanoic acid-1-14-C, and trans-2-hexadecenoic acid-1-14-C.

PubMed

Jones, J A; Blecher, M

1966-05-01

The chemical synthesis and characterization of three intermediates in the Beta oxidation of palmitic acid-1-(14)C by rat liver mitochondria, namely, 3-ketohexadecanoic acid-1-(14)C, DL-3-hydroxyhexadecanoic acid-1-(14)C, and trans-2-hexadecenoic acid-1-(14)C, are described.

Birth, life, and demise of the Andean-syn-collisional Gissar arc: Late Paleozoic tectono-magmatic-metamorphic evolution of the southwestern Tian Shan, Tajikistan

NASA Astrophysics Data System (ADS)

Worthington, James R.; Kapp, Paul; Minaev, Vladislav; Chapman, James B.; Mazdab, Frank K.; Ducea, Mihai N.; Oimahmadov, Ilhomjon; Gadoev, Mustafo

2017-10-01

The amalgamation of the Central Asian Orogenic Belt in the southwestern Tian Shan in Tajikistan is represented by tectono-magmatic-metamorphic processes that accompanied late Paleozoic ocean closure and collision between the Karakum-Tarim and Kazakh-Kyrgyz terranes. Integrated U-Pb geochronology, thermobarometry, pseudosection modeling, and Hf geochemistry constrain the timing and petro-tectonic nature of these processes. The Gissar batholith and the Garm massif represent an eastward, along-strike increase in paleodepth from upper-batholith ( 21-7 km) to arc-root ( 36-19 km) levels of the Andean-syn-collisional Gissar arc, which developed from 323-288 Ma in two stages: (i) Andean, I-type granitoid magmatism from 323-306 Ma due to northward subduction of the Gissar back-arc ocean basin under the Gissar microcontinent, which was immediately followed by (ii) syn-collisional, I-S-type granitoid magmatism in the Gissar batholith and the Garm massif from 304-288 Ma due to northward subduction/underthrusting of Karakum marginal-continental crust under the Gissar microcontinent. A rapid isotopic pull-up from 288-286 Ma signals the onset of juvenile, alkaline-syenitic, post-collisional magmatism by 280 Ma, which was driven by delamination of the Gissar arclogite root and consequent convective asthenospheric upwelling. Whereas M-HT/LP prograde metamorphism in the Garm massif (650-750°C/6-7 kbar) from 310-288 Ma was associated with subduction-magma inundation and crustal thickening, HT/LP heating and decompression to peak-metamorphic temperatures ( 800-820°C/6-4 kbar) at 288 ± 6 Ma was driven by the transmission of a post-collisional, mantle-derived heat wave through the Garm-massif crust.

Charles Dicken’s Use of Folklore: A Study of Elements in Bleak House

DTIC Science & Technology

1981-04-21

witchcraft . This association is first seen In Bleak House when the son of Chancery is identified as the accoutarit-general and Chancery’ father 1 i ’,i,’wi...story of Little Red Riding Hood had undertones of witchcraft md cannibalism, Esther’s other offering, "Puss N1’ Boots," was concerned with a helpful...since the early days of the church and as a result of this association, Jews had a reputation for practicing evil and witchcraft (114/108). Reference

Biodegradation of DIMP, Dieldrin, Isodrin, DBCP, and PCPMSO in Rocky Mountain Arsenal Soils. Installation Restoration Program, Environmental Technology Development

DTIC Science & Technology

1989-01-01

Number DAAK- 1 1 -85-D-007 Report Number CETHA-TE-CR-89006 January 1989 Prepared for: COMMANDER, U.S. ARMY TOXIC AND HAZARDOUS MATERIALS AGENCY Aberdeen...UNIT Aberdeen Proving Ground, MD 21010-5401 ELEMENT NO. NO. NO. ACCESSION NO. 1 . TITLE (Include Security Classification) - Biodegradation of DIMP...TYPE OF REPORT 113b. TIME COVERED 114. DATE OF REPORT (Year, Month, Day) 15. PAGE COUNT Final I FROM 1 /87 TO_1/89 1989 January 30 6. SUPPLEMENTARY

High-throughput simultaneous determination of plasma water deuterium and 18-oxygen enrichment using a high-temperature conversion elemental analyzer with isotope ratio mass spectrometry.

PubMed

Richelle, M; Darimont, C; Piguet-Welsch, C; Fay, L B

2004-01-01

This paper presents a high-throughput method for the simultaneous determination of deuterium and oxygen-18 (18O) enrichment of water samples isolated from blood. This analytical method enables rapid and simple determination of these enrichments of microgram quantities of water. Water is converted into hydrogen and carbon monoxide gases by the use of a high-temperature conversion elemental analyzer (TC-EA), that are then transferred on-line into the isotope ratio mass spectrometer. Accuracy determined with the standard light Antartic precipitation (SLAP) and Greenland ice sheet precipitation (GISP) is reliable for deuterium and 18O enrichments. The range of linearity is from 0 up to 0.09 atom percent excess (APE, i.e. -78 up to 5725 delta per mil (dpm)) for deuterium enrichment and from 0 up to 0.17 APE (-11 up to 890 dpm) for 18O enrichment. Memory effects do exist but can be avoided by analyzing the biological samples in quintuplet. This method allows the determination of 1440 samples per week, i.e. 288 biological samples per week. Copyright 2004 John Wiley & Sons, Ltd.

Follistatin: A Potential Anabolic Treatment for Re-Innervated Muscle

DTIC Science & Technology

2016-09-01

and force generation studies of tibial nerve and gastrocnemius muscle.- pending • Immunohistology staining and histology of muscle (3 months) Fiber...Cross sections of muscle specimens will be stained and fiber size, axon numbers, and myelination measured.- pending • Data Analysis (3 months...AV-288 Follistatin 5 Control 5 Follistatin Protein 2 Animal Weight ( grams ): AV FS-288 (FPP6 to FPP10) Average 256.72 STDEV 6.28267459

The Development of Empathy in Chinese and American Children Between Three and Six Years of Age: A Cross-Cultural Study.

ERIC Educational Resources Information Center

Borke, Helene

A series of social interaction situations representing the four emotions of happy, afraid, sad, and angry were administered to 288 American children and 288 Chinese children. Twenty-four girls and 24 boys, half from middle class families and half from disadvantaged families, were tested at six-month intervals between 3 and 6 years of age. Children…

Assessment of growth and spectral properties of Cr3+-doped La0.83Y0.29Sc2.88(BO3)4 crystal

NASA Astrophysics Data System (ADS)

Huang, Yisheng; Sun, Shijia; Lin, Zhoubin; Zhang, Lizhen; Wang, Guofu

2017-10-01

This paper reports the spectral characteristic of Cr3+-doped La0.83Y0.29 Sc2.88 (BO3)4 crystal. Cr3+-doped La0.83Y0.29Sc2.88 (BO3)4 crystal was grown from a flux of Li6B4O9 by the top seeded Solution growth method. Cr3+:La0.83Y0.29 Sc2.88 (BO3)4 crystal exhibits broad absorption and emission bands of Cr3+ ions. The absorption cross-section σa is 3.38 × 10-20 cm2 at 467 nm and 4.40 × 10-20 cm2 at 656 nm for E//c, respectively. The emission band with a peak at 906 nm has a full width at half maximum (FWHM) of 188 nm for E//c. The emission cross-section σe at 906 nm is 2.35 × 10-20 cm2 for E//c axis and 2.03 × 10-20 cm2 for E⊥c axis. The fluorescence lifetime of 4T2 → 4A2 transition is 37.7 μs. The investigated result indicates that it may be considered as a potential CW tunable laser crystal material.

Gas phase chemical studies of superheavy elements using the Dubna gas-filled recoil separator - Stopping range determination

NASA Astrophysics Data System (ADS)

Wittwer, D.; Abdullin, F. Sh.; Aksenov, N. V.; Albin, Yu. V.; Bozhikov, G. A.; Dmitriev, S. N.; Dressler, R.; Eichler, R.; Gäggeler, H. W.; Henderson, R. A.; Hübener, S.; Kenneally, J. M.; Lebedev, V. Ya.; Lobanov, Yu. V.; Moody, K. J.; Oganessian, Yu. Ts.; Petrushkin, O. V.; Polyakov, A. N.; Piguet, D.; Rasmussen, P.; Sagaidak, R. N.; Serov, A.; Shirokovsky, I. V.; Shaughnessy, D. A.; Shishkin, S. V.; Sukhov, A. M.; Stoyer, M. A.; Stoyer, N. J.; Tereshatov, E. E.; Tsyganov, Yu. S.; Utyonkov, V. K.; Vostokin, G. K.; Wegrzecki, M.; Wilk, P. A.

2010-01-01

Currently, gas phase chemistry experiments with heaviest elements are usually performed with the gas-jet technique with the disadvantage that all reaction products are collected in a gas-filled thermalisation chamber adjacent to the target. The incorporation of a physical preseparation device between target and collection chamber opens up the perspective to perform new chemical studies. But this approach requires detailed knowledge of the stopping force (STF) of the heaviest elements in various materials. Measurements of the energy loss of mercury (Hg), radon (Rn), and nobelium (No) in Mylar and argon (Ar) were performed at low kinetic energies of around (40-270) keV per nucleon. The experimentally obtained values were compared with STF calculations of the commonly used program for calculating stopping and ranges of ions in matter (SRIM). Using the obtained data points an extrapolation of the STF up to element 114, eka-lead, in the same stopping media was carried out. These estimations were applied to design and to perform a first chemical experiment with a superheavy element behind a physical preseparator using the nuclear fusion reaction 244Pu( 48Ca; 3n) 289114. One decay chain assigned to an atom of 285112, the α-decay product of 289114, was observed.

The cross sections of fusion-evaporation reactions: the most promising route to superheavy elements beyond Z=118

NASA Astrophysics Data System (ADS)

Jadambaa, Khuyagbaatar

2017-11-01

The synthesis of superheavy elements beyond oganesson (Og), which has atomic number Z = 118, is currently one of the main topics in nuclear physics. An absence of sufficient amounts of target material with atomic numbers heavier than californium (Z = 98) forces the use of projectiles heavier than 48Ca (Z = 20), which has been successfully used for the discoveries of elements with Z = 114 - 118 in complete fusion reactions. Experimental cross sections of 48Ca with actinide targets behave very differently to "cold" and "hot" fusion-evaporation reactions, where doubly-magic lead and deformed actinides are used as targets, respectively. The known cross sections of these reactions have been analysed compared to calculated fission barriers. It has been suggested that observed discrepancies between the cross sections of 48Ca-induced and other fusionevaporation reactions originate from the shell structure of the compound nucleus, which lies in the island of the stability. Besides scarcely known data on other reactions involving heavier projectiles, the most promising projectile for the synthesis of the elements beyond Og seems to be 50Ti. However, detailed studies of 50Ti, 54Cr, 58Fe and 64Ni-induced reactions are necessary to be performed in order to fully understand the complexities of superheavy element formation.

Chemical composition and pharmacological significance of Anethum Sowa L. Root.

PubMed

Saleh-E-In, Md Moshfekus; Sultana, Nasim; Rahim, Md Matiur; Ahsan, Md Aminul; Bhuiyan, Md Nurul Huda; Hossain, Md Nur; Rahman, Md Mahbubar; Kumar Roy, Sudhangshu; Islam, Md Rabiul

2017-02-23

Medicinal herbs are used for the treatment of different ailments since antiquity. Different parts of Anethum sowa L. is used in folk medicine as a carminative for the treatment of flatulence, colic and hiccups of infants and children, antioxidant, antimicrobial and antispasmodic agent. The aim of our present study is to evaluate the chemical composition of the essential oil, proximate and elemental composition, amino acid, fatty acid profile and thermal behaviour of its root part as well as different pharmacological activities like antioxidant, antimicrobial and cytotoxicity of the root essential oil. The air-dried roots of Anethum sowa L. were subjected to hydro-distillation to yield the essential oil. The antioxidant activity of the essential oil was studied by DPPH radical scavenging activity. The antimicrobial activity was tested against four Gram-positive, six Gram-negative bacteria and four fungi species. The minimum inhibitory concentration (MIC) and Minimum bacterial concentration (MBC) for each examined microorganism were determined using the micro-dilution method. The LC 50 value of the oil was also evaluated by brine shrimp lethality assay. The subsequent proximate analysis was also done by AOAC methods. The elemental analysis of the root powder was analysed by ICP-MS, AAS and FP system. The fatty acid was extracted by hot and cold extraction method and the analyses were carried out by GC. The amino acid profile was done by the amino acid analyzer. The DTA, DTG and TG of the root powder were taken by the thermogravimetric analyzer. A total of 24 constituents was identified and quantified in the essential oil and its water extract portion by GC and GC-MS. Apiol (81.99 and 74.779%) was found the highest phenylpropanoid constituent followed by m-diaminobenzene (10.446 and 8.778%) in the essential oil and aqueous extract portion. On the other hand, β-butyrolactone (5.13%) and isobutyl acetone (3.73%) were found in the major constituents in the water extract part. The IC 50 value of the essential oil was found to be 3.07 mg/mL by DPPH radical assay methods. The LC 50 value of the brine shrimp cytotoxicity assay of the essential oil was observed at 0.81 μg/mL. The essential oil showed better activity on Gram-negative bacteria than Gram-positive bacteria and fungi. The proximate composition showed that root contained 5.29% ash, 2.01% protein, 54.09% crude fibre, 0.15% essential oil and 1.14% fatty oil for hot extract and 0.23% for cold extract on the dried basis. The palmitic (33.81 & 31.58%) and linoleic acid (30.03 & 23.79%) were the major saturated and unsaturated fatty acids in the cold and hot extracted root powder respectively. Ca (23,600 mg/kg), Mg (7620.33 mg/kg) and K (1286.15 mg/kg) were the most predominant elements followed by Ni (1187.30 mg/kg), Se (913.79 mg/kg), Li (317.84 mg/kg), Na (288.72 mg/kg) and Fe (206.88 mg/kg). The toxic elements were found to be within the permissible limit. Glutamic acid (19.37%), glycine (14.53%) and lysine (17.08%) were found as the major amino acids. The decomposition rates were obtained by TG, DTG and DTA curve of the powder sample at various temperature ranges. The results demonstrated that the root part of Anethum sowa L. is a rich source of mineral elements, essential amino acid and fatty acids. The essential oil is the highly potential as bioactive oil for pharmaceuticals and medical applications, possessing antioxidant, antimicrobial and cytotoxic activities. The thermal analysis suggested as a simple, effective and rapid method to characterize the Anethum sowa L. species as well as to assess for herbal formulation.

Using Animated Computer Simulation to Determine the Optimal Resource Support for the Endodontic Specialty Practice at Fort Lewis.

DTIC Science & Technology

1998-03-01

Series Pt Endo Tx 114 Time Series Pt Perio Ex 114 None Pt Perio Tx 114 None Pt Perio Sx 114 None Pt Perio Pot 114 None Pt Exam 114 None Pt Other...prevention, diagnosis, and treatment of diseases and injuries that affect the dental pulp, tooth root, and periapical tissue" (Jablonski, 1982...Time Priority Scheduled Disable Logic Entrance 1 480 99 Yes No wait 180 * Entities * Name Speed (fpm) Stats Pt Endo Ex 114 Time

78 FR 73109 - Radio Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-05

... Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and Shamrock, TX AGENCY... 237C3 at Benjamin, Texas; Channel 261C3 at Cisco, Texas; Channel 288C2 at Rule, Texas; and Channel 225C2..., Channel 237C3; by removing Cisco, Channel 261C3; by removing Channel 288C2 at Rule; and by removing...

The Discovery of the b Quark at Fermilab in 1977: The Experiment Coordinator's Story

DOE R&D Accomplishments Database

Yoh, J.

1997-12-01

I present the history of the discovery of the Upsilon ({Upsilon}) particle (the first member of the b-quark family to be observed) at Fermilab in 1977 by the CFS (Columbia-Fermilab-Stony Brook collaboration) E288 experiment headed by Leon Lederman. We found the first evidence of the {Upsilon} in November 1976 in an early phase of E288. The subsequent discovery in the spring of 1977 resulted from an upgraded E288 the {mu}{mu}II phase, optimized for dimuons, with about 100 times the sensitivity of the previous investigatory dimuon phase (which had been optimized for dielectrons). The events leading to the discovery, the planning of {mu}{mu}II and the running, including a misadventure (the infamous Shunt Fire of May 1977), are described. Some discussions of the aftermath, a summary, and an acknowledgement list end this brief historical note.

Comparison of PD-L1 mRNA Expression Measured with the CheckPoint Typer® Assay with PD-L1 Protein Expression Assessed with Immunohistochemistry in Non-small Cell Lung Cancer.

PubMed

Erber, Ramona; Stöhr, Robert; Herlein, Stefanie; Giedl, Claudia; Rieker, Ralf Joachim; Fuchs, Florian; Ficker, Joachim H; Hartmann, Arndt; Veltrup, Elke; Wirtz, Ralph M; Brueckl, Wolfgang M

2017-12-01

Immunohistochemical (IHC) assessment of programmed death-ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) has become important since the development of anti-PD-1/-PD-L1 directed drugs. Various PD-L1 antibodies and cut-offs have been used in different trials to predict response to these drugs, thus comparison of those studies is difficult. We compared PD-L1 mRNA expression measured by RT-qPCR with PD-L1 protein expression evaluated by IHC. Moreover, we investigated the impact of different tumour tissue acquisition methods on the reliability of PD-L1 measurement techniques. NSCLC cases (N=22), including n=9 mediastinal lymph node biopsies acquired by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and n=5 metastases, were evaluated prospectively for PD-L1 protein on tumor cells (TC) and immune cells (IC) using E1L3N and 28-8 antibodies and PD-L1 mRNA using the CheckPoint TYPER® assay. In primary NSCLC tissues, agreement between PD-L1 mRNA and TC staining using the 28-8 antibody was excellent (ĸ=0.85, p=0.0002). Comparing both PD-L1 antibodies against each other showed a kappa value of 0.58 (p=0.0106). In EBUS-TBNA, PD-L1 mRNA correlated perfectly with the 28-8 antibody (ĸ=1.0, p=0.0023). PD-L1 mRNA levels significantly differed when comparing 28-8 TC staining of tumours >49% with 1-49% and 0% (p=0.0040; p=0.0081, respectively). In metastatic lesions, differences between PD-L1 mRNA and IHC became apparent (ĸ=0.2, p=0.2525). Testing of PD-L1 mRNA and 28-8 IHC showed an excellent agreement in NSCLC samples including mediastinal lymph node biopsies. Since PD-L1 expression in >50% TC detected by 28-8 IHC can be reliably detected by RT-qPCR, quantitative PD-L1 mRNA determination should be considered as an alternative to IHC as there is no interobserver variability in RNA results. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Raman and and x-ray diffraction study of iron and iron-nickel alloys at varying P-T conditions

NASA Astrophysics Data System (ADS)

Goncharov, A.; Struzhkin, V.; Gregoryanz, E.; Maddury, S.; Huang, E.; Hemley, R. J.; Mao, H.

2002-05-01

High-pressure properties of iron and iron-rich alloys are crucial for understanding of the Earth interior, because iron is the major constitute element of the Earth core. Using recently developed [1,2] Raman spectroscopy technique for shear elastic modulus determination, we studied iron-rich alloys of Ni (0 to 20 % Ni) up to 150 GPa, and also at varying temperatures (78-400 K). We find substantial decrease of the Raman hcp-phonon frequency compared to the pure iron, and also considerable anharmonic temperature effects. In contrast, low-temperature x-ray diffraction measurements indicate a usual temperature variation of the lattice constants. Possible implications to the Earth core composition and properties are discussed. [1] A. P. Jephcoat, H. Olijnyk, K. Refson, Eos 80, F929 (1999). [2] S. Merkel et al., Science 288, 1626 (2000).

Comparison of in situ versus in vitro methods of fiber digestion at 120 and 288 hours to quantify the indigestible neutral detergent fiber fraction of corn silage samples.

PubMed

Bender, R W; Cook, D E; Combs, D K

2016-07-01

Ruminal digestion of neutral detergent fiber (NDF) is affected in part by the proportion of NDF that is indigestible (iNDF), and the rate at which the potentially digestible NDF (pdNDF) is digested. Indigestible NDF in forages is commonly determined as the NDF residue remaining after long-term in situ or in vitro incubations. Rate of pdNDF digestion can be determined by measuring the degradation of NDF in ruminal in vitro or in situ incubations at multiple time points, and fitting the change in residual pdNDF by time with log-transformed linear first order or nonlinear mathematical treatments. The estimate of indigestible fiber is important because it sets the pool size of potentially digestible fiber, which in turn affects the estimate of the proportion of potentially digestible fiber remaining in the time series analysis. Our objective was to compare estimates of iNDF based on in vitro (IV) and in situ (IS) measurements at 2 fermentation end points (120 and 288h). Further objectives were to compare the subsequent rate, lag, and estimated total-tract NDF digestibility (TTNDFD) when iNDF from each method was used with a 7 time point in vitro incubation of NDF to model fiber digestion. Thirteen corn silage samples were dried and ground through a 1-mm screen in a Wiley mill. A 2×2 factorial trial was conducted to determine the effect of time of incubation and method of iNDF analysis on iNDF concentration; the 2 factors were method of iNDF analysis (IS vs. IV) and incubation time (120 vs. 288h). Four sample replicates were used, and approximately 0.5g/sample was weighed into each Ankom F 0285 bag (Ankom Technology, Macedon, NY; pore size=25 µm) for all techniques. The IV-120 had a higher estimate of iNDF (37.8% of NDF) than IS-120 (32.1% of NDF), IV-288 (31.2% of NDF), or IS-288 technique (25.7% of NDF). Each of the estimates of iNDF was then used to calculate the rate of degradation of pdNDF from a 7 time point in vitro incubation. When the IV-120 NDF residue was used, the subsequent rates of pdNDF digestion were fastest (2.8% h(-1)) but the estimate of lag was longest (10.3h), compared with when iNDF was based on the IS-120 or IV-288 NDF residues (rates of 2.3%h(-1) and 2.4%h(-1); lag times of 9.7 and 9.8 h, respectively). Rate of pdNDF degradation was slowest (2.1% h(-1)) when IS-288 NDF residue was used as the estimate of iNDF. The estimate of lag based on IS-288 (9.4h) was similar to lag estimates calculated when IS-120 or IV-288 were used as the estimate of iNDF. The TTNDFD estimates did not differ between treatments (35.5%), however, because differences in estimated pools of iNDF resulted in subsequent changes in rates and lag times of fiber digestion that tended to cancel out. Estimates of fiber digestion kinetic parameters and TTNDFD were similar when fit to either the linear or nonlinear fiber degradation models. All techniques also yielded estimates of iNDF that were higher than predicted iNDF based on the commonly used ratio of 2.4 × lignin. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Mission Command in an Age of Persistent Conflict: Historical And Theoretical Approaches to Developing Mission Command

DTIC Science & Technology

2014-04-01

2011): 288. 31 Ibid., 288. 32 Littlejohn, Theories of Human Communication , 3. 33 Franklin Fearing, “Toward a Psychological Theory of Human ...Stephen W. Theories of Human Communication . Belmont, CA: Wadsworth Publishing Company, 1983. Paul, Richard. The Thinker’s Guide to the Nature and... Communication ,” in Foundations of Communication Theory, ed. Kenneth K. Sereno et al. (New York: Harper and Row, Publishers, 1970), 48-49. 34 Peter A. Facione

Compendium of Post-Failure Analysis Techniques for Composite Materials.

DTIC Science & Technology

1987-01-01

HHdrocarbon 285.0 Ether or alcohol 286.5 Ketone 288.0 Ester 288.8 (Ref. 5) Figure 3-37. Carbon Peak Shifts in XPS 5-B70227Rt -130 " Hydrocarbon...structure overlays composite material since neutrons are not as attenuated by metal as X-rays, and are relatively sensitive to poly - meric materials...Thermal Aging 3-18 Glass Transition Temperature Determination - 3-37 TMA Penetration Test Setup 3-19 Glass Transition Temperature Determination - 3-37 TMA

A binary main-belt comet.

PubMed

Agarwal, Jessica; Jewitt, David; Mutchler, Max; Weaver, Harold; Larson, Stephen

2017-09-20

Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids called main-belt comets, the sublimation of excavated volatiles causes transient comet-like activity. Torques exerted by sublimation measurably influence the spin rates of active comets and might lead to the splitting of bilobate comet nuclei. The kilometre-sized main-belt asteroid 288P (300163) showed activity for several months around its perihelion 2011 (ref. 11), suspected to be sustained by the sublimation of water ice and supported by rapid rotation, while at least one component rotates slowly with a period of 16 hours (ref. 14). The object 288P is part of a young family of at least 11 asteroids that formed from a precursor about 10 kilometres in diameter during a shattering collision 7.5 million years ago. Here we report that 288P is a binary main-belt comet. It is different from the known asteroid binaries in its combination of wide separation, near-equal component size, high eccentricity and comet-like activity. The observations also provide strong support for sublimation as the driver of activity in 288P and show that sublimation torques may play an important part in binary orbit evolution.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, Dongwook; Han, Sang-Il; Lee, Young-Wook

There is increasing evidence for the presence of multiple red giant branches (RGBs) in the color-magnitude diagrams of massive globular clusters (GCs). In order to investigate the origin of this split on the RGB, we have performed new narrow-band Ca photometry and low-resolution spectroscopy for M22, NGC 1851, and NGC 288. We find significant differences (more than 4σ) in calcium abundance from the spectroscopic HK' index for M22 and NGC 1851. We also find more than 8σ differences in CN-band strength between the Ca-strong and Ca-weak subpopulations for these GCs. For NGC 288, however, a large difference is detected onlymore » in the CN strength. The calcium abundances of RGB stars in this GC are identical to within the errors. This is consistent with the conclusion from our new Ca photometry where the RGB splits are confirmed in M22 and NGC 1851, but not in NGC 288. We also find interesting differences in the CN-CH correlations among these GCs. While CN and CH are anti-correlated in NGC 288, they show a positive correlation in M22. NGC 1851, however, shows no difference in CH between the two groups of stars with different CN strengths. We suggest that all of these systematic differences would be best explained by how strongly Type II supernovae enrichment has contributed to the chemical evolution of these GCs.« less

CHANDRA Observations OF The Shock Heated Gas Around 3c 288 And 3c 449

NASA Astrophysics Data System (ADS)

Lal, Dharam V.; Kraft, R. P.; Evans, D. A.; Hardcastle, M. J.; Nulsen, P. E. J.; Croston, J. H.; Forman, W. R.; Jones, C.; Lee, J. C.

2010-03-01

The inflation of radio bubbles in the hot gas atmospheres of clusters of galaxies plays an important role in the overall energy budget of the ICM. Regular gentle (i.e. subsonic) nuclear outbursts may be able to provide sufficient energy to the gas in the cool cores of clusters to offset radiative losses and regulate large cooling flows; and one method to supplement the total energy input into the gas is for the lobes to initially drive strong shocks into the gas. We present results from Chandra/ACIS-S observations of the hot gas atmospheres of two powerful, nearby radio galaxies in poor clusters: 3C 288 and 3C 449. We measure the total energy of the current outburst to be a few times 10^{59} ergs for 3C 288 (T = 2.8 keV, L_X = 1.4 × 10^{44} ergs) and ˜10^{58} ergs for 3C 449 (T = 1.5 keV, L_X = 2.0 × 10^{42} ergs). We find multiple surface brightness discontinuities in the gas, which are probably shocks and are indicative of supersonic heating by the inflation of the radio lobe. We do not find X-ray cavity in 3C 288, whereas cavities are associated with both the radio lobes in 3C 449.

13 CFR 114.100 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Definitions. 114.100 Section 114.100 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION ADMINISTRATIVE CLAIMS UNDER THE... § 114.100 Definitions. As used throughout this part 114, date of accrual means the date you know or...

Measles, mumps, rubella, and varicella seroprevalence in refugees in Germany in 2015.

PubMed

Jablonka, Alexandra; Happle, Christine; Grote, Ulrike; Schleenvoigt, Benjamin Thomas; Hampel, Annika; Dopfer, Christian; Hansen, Gesine; Schmidt, Reinhold Ernst; Behrens, Georg M N

2016-12-01

The current extent of migration poses emerging socio-economic and humanitarian challenges. Little is known on vaccination rates in migrants entering Europe, and the implementation of guidelines for serological testing and vaccination of refugees are pending. We conducted seroprevalence analyses for measles, mumps, rubella and varicella (MMRV) in 678 refugees coming to Germany during the current crisis. The mean age of refugees was 28.8±11.4 years, and 76.1 % of subjects were male. Overall, IgG seronegativity was 7.4 % (95 % CI 5.5-9.6) for measles, 10.2 % (95 % CI 8.0-12.5) for mumps, 2.2 % (95 % CI 1.2-3.4) for rubella, and 3.3 % (95 % CI 1.9-4.9) for varicella. Seropositivity rates were age-dependent with considerably low values in children. For example, overall MMR immunity was 90.9 % (95 % CI 88.8-93.1), but only 73.1 % of minor aged refugees displayed complete seroprevalence against all three diseases, and only 68.9 % of children and adolescents were completely MMRV immune. Our initial data set suggests overall satisfactory MMRV immunity in adult migrants coming to Europe, but the observed low MMRV seroprevalences in refugee children support thorough and prompt vaccination of young migrants entering Europe. Taken together, our data set underlines the urgent need to implement and validate vaccination guidelines for refugee care in the current crisis.

Langley Aerospace Research Summer Scholars. Part 2

NASA Technical Reports Server (NTRS)

Schwan, Rafaela (Compiler)

1995-01-01

The Langley Aerospace Research Summer Scholars (LARSS) Program was established by Dr. Samuel E. Massenberg in 1986. The program has increased from 20 participants in 1986 to 114 participants in 1995. The program is LaRC-unique and is administered by Hampton University. The program was established for the benefit of undergraduate juniors and seniors and first-year graduate students who are pursuing degrees in aeronautical engineering, mechanical engineering, electrical engineering, material science, computer science, atmospheric science, astrophysics, physics, and chemistry. Two primary elements of the LARSS Program are: (1) a research project to be completed by each participant under the supervision of a researcher who will assume the role of a mentor for the summer, and (2) technical lectures by prominent engineers and scientists. Additional elements of this program include tours of LARC wind tunnels, computational facilities, and laboratories. Library and computer facilities will be available for use by the participants.

Application of the mass-spectrometer MASHA for mass-spectrometry and laser-spectroscopy

NASA Astrophysics Data System (ADS)

Rodin, A. M.; Belozerov, A. V.; Dmitriev, S. N.; Oganessian, Yu. Ts.; Sagaidak, R. N.; Salamatin, V. S.; Stepantsov, S. V.; Vanin, D. V.

2010-02-01

We report the present status of the mass-spectrometer MASHA (Mass-Analyzer of Supper Heavy Atoms) designed for determination of the masses of superheavy elements. The mass-spectrometer is connected to the U-400M cyclotron of the Flerov Laboratory for Nuclear Reactions (FLNR) JINR, Dubna. The first experiments on mass-measurements for 112 and 114 elements will be performed in the upcoming 2010. For this purpose a hot catcher, based on a graphite stopper, is constructed. The α-decay of the superheavy nuclides or spontaneous fission products will be detected with a silicon 192 strips detector. The experimental program of future investigations using the technique of a gas catcher is discussed. It should be regarded as an alternative of the classical ISOL technique. The possibilities are considered for using this mass-spectrometer for laser spectroscopy of nuclei far off-stability.

Technical Reports: Langley Aerospace Research Summer Scholars. Part 1

NASA Technical Reports Server (NTRS)

Schwan, Rafaela (Compiler)

1995-01-01

The Langley Aerospace Research Summer Scholars (LARSS) Program was established by Dr. Samuel E. Massenberg in 1986. The program has increased from 20 participants in 1986 to 114 participants in 1995. The program is LaRC-unique and is administered by Hampton University. The program was established for the benefit of undergraduate juniors and seniors and first-year graduate students who are pursuing degrees in aeronautical engineering, mechanical engineering, electrical engineering, material science, computer science, atmospheric science, astrophysics, physics, and chemistry. Two primary elements of the LARSS Program are: (1) a research project to be completed by each participant under the supervision of a researcher who will assume the role of a mentor for the summer, and (2) technical lectures by prominent engineers and scientists. Additional elements of this program include tours of LARC wind tunnels, computational facilities, and laboratories. Library and computer facilities will be available for use by the participants.

Study of SHE at SHIP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofmanna, Sigurd; Institut fuer Kernphysik, Goethe-Universitaet Frankfurt, Max von Laue-Strasse 1, 60438 Frankfurt am Main

2010-06-01

The nuclear shell model predicts that the next doubly magic shell-closure beyond {sup 208}Pb is at a proton number Z = 114, 120, or 126 and at a neutron number N = 184. The outstanding aim of experimental investigations is the exploration of this region of spherical 'SuperHeavy Elements'(SHEs). Experimental methods are described, which allowed for the identification of elements produced on a cross-section level of about 1 pb. Reactions used at SHIP are based on targets of lead and uranium. The decay data reveal that for the heaviest elements, the dominant decay mode is alpha emission, not fission. Decaymore » properties as well as reaction cross-sections are compared with results obtained at other laboratories and with results of theoretical investigations. Finally, plans are presented for the further development of the experimental set-up and the application of new techniques, as for instance the precise mass measurement of the produced nuclei using ion traps. At increased sensitivity, detailed exploration of the region of spherical SHEs will start, after first steps on the island of SHEs were made in recent years.« less

Studies of SHE at SHIP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hofmann, Sigurd; Institut fuer Kernphysik, Goethe-Universitaet Frankfurt, Max von Laue-Strasse 1, 60438 Frankfurt am Main

2010-04-30

The nuclear shell model predicts that the next doubly magic shell-closure beyond {sup 208}Pb is at a proton number Z = 114, 120, or 126 and at a neutron number N = 184. The outstanding aim of experimental investigations is the exploration of this region of spherical 'Super-Heavy Elements'(SHEs). Experimental methods are described, which allowed for the identification of elements produced on a cross-section level of about 1 pb. Reactions used at SHIP are based on targets of lead and uranium. The decay data reveal that for the heaviest elements, the dominant decay mode is alpha emission, not fission. Decaymore » properties as well as reaction cross-sections are compared with results obtained at other laboratories and with results of theoretical investigations. Finally, plans are presented for the further development of the experimental setup and the application of new techniques, as for instance the precise mass measurement of the produced nuclei using ion traps. At increased sensitivity, detailed exploration of the region of spherical SHEs will start, after first steps on the island of SHEs were made in recent years.« less

A Study to Determine the Role of Competition in Contracting for the Movement of Air Freight within the Domestic Market.

DTIC Science & Technology

1980-06-01

ES2ABLISHMENT OF MOBILIZATION VALUES FOR SELECTED AIRCRAFT ... ............ 83 B. INTERVIEW GUIDE , SUBPROBLEM 1 .. ......... 87 C. INTERVIEW GUIDE , SUBPROBLEM...2 (PEACETIME). ... 91 D. INTERVIEW GUIDE , SUBPROBLEM 2 (EMERGENCY) . 96 E. FORMAL QUESTIONNAIRE, SUBPROBLEM 3 ........ .100 vi Page F. INTERVIEW GUIDE ... ratemaking func- tion under part 288 [of the FAA Act of 19581. On the basis of this review, we propose for three principal reasons to amend Part 288 to

Effects of Prior Aging at 288 deg C in Argon Environment on Creep Response of Carbon Fiber Reinforced PMR-15 Composite with + or - 45 deg Fiber Orientation at 288 deg C

DTIC Science & Technology

2009-06-01

typically consists of a thermoset or thermoplastic polymer matrix reinforced with fibers that are much stronger and stiffer than the matrix. The PMCs are...high thermal or electrical conductivity, stealth characteristics , the ability to self-heal, communication, and sensor capabilities. The multi...have factual evidence of limitations and characteristics so as to utilize the material in a manner consistent with its strengths and weaknesses

Effects of Prior Aging on the Creep Response of Carbon Fiber Reinforced PMR-15 Neat Resin at 288 C in an Air Environment

DTIC Science & Technology

2007-06-01

strain versus creep time curves. During creep , stress remains constant, but strain increases. The creep curves of the unaged specimens at 30...recovery period and then levels off and remains nearly constant until the end of the recovery period. The amount of creep strain recovered may...EFFECTS OF PRIOR AGING ON THE CREEP RESPONSE OF CARBON FIBER REINFORCED PMR-15 NEAT RESIN AT 288ºC IN

Effect of high-temperature water and hydrogen on the fracture behavior of a low-alloy reactor pressure vessel steel

NASA Astrophysics Data System (ADS)

Roychowdhury, S.; Seifert, H.-P.; Spätig, P.; Que, Z.

2016-09-01

Structural integrity of reactor pressure vessels (RPV) is critical for safety and lifetime. Possible degradation of fracture resistance of RPV steel due to exposure to coolant and hydrogen is a concern. In this study tensile and elastic-plastic fracture mechanics (EPFM) tests in air (hydrogen pre-charged) and EFPM tests in hydrogenated/oxygenated high-temperature water (HTW) was done, using a low-alloy RPV steel. 2-5 wppm hydrogen caused embrittlement in air tensile tests at room temperature (25 °C) and at 288 °C, effects being more significant at 25 °C and in simulated weld coarse grain heat affected zone material. Embrittlement at 288 °C is strain rate dependent and is due to localized plastic deformation. Hydrogen pre-charging/HTW exposure did not deteriorate the fracture resistance at 288 °C in base metal, for investigated loading rate range. Clear change in fracture morphology and deformation structures was observed, similar to that after air tests with hydrogen.

Life on rock. Scaling down biological weathering in a new experimental design at Biosphere-2

NASA Astrophysics Data System (ADS)

Zaharescu, D. G.; Dontsova, K.; Burghelea, C. I.; Chorover, J.; Maier, R.; Perdrial, J. N.

2012-12-01

Biological colonization and weathering of bedrock on Earth is a major driver of landscape and ecosystem development, its effects reaching out into other major systems such climate and geochemical cycles of elements. In order to understand how microbe-plant-mycorrhizae communities interact with bedrock in the first phases of mineral weathering we developed a novel experimental design in the Desert Biome at Biosphere-2, University of Arizona (U.S.A). This presentation will focus on the development of the experimental setup. Briefly, six enclosed modules were designed to hold 288 experimental columns that will accommodate 4 rock types and 6 biological treatments. Each module is developed on 3 levels. A lower volume, able to withstand the weight of both, rock material and the rest of the structure, accommodates the sampling elements. A middle volume, houses the experimental columns in a dark chamber. A clear, upper section forms the habitat exposed to sunlight. This volume is completely sealed form exterior and it allows a complete control of its air and water parameters. All modules are connected in parallel with a double air purification system that delivers a permanent air flow. This setup is expected to provide a model experiment, able to test important processes in the interaction rock-life at grain-to- molecular scale.

Contamination of infectious RD-114 virus in vaccines produced using non-feline cell lines.

PubMed

Yoshikawa, Rokusuke; Sato, Eiji; Miyazawa, Takayuki

2011-01-01

All domestic cats have a replication-competent endogenous retrovirus, termed RD-114 virus, in their genome and several feline cell lines produce RD-114 viruses. Recently, we found that a portion of live attenuated feline and canine vaccines produced using feline cell lines was contaminated with infectious RD-114 viruses. In this study, we expanded our survey and examined canine vaccines produced using 'non-feline' cell lines. Consequently, we found two vaccines containing RD-114 viral RNA by reverse transcriptase (RT)-polymerase chain reaction (PCR) and real-time RT-PCR. We also confirmed the presence of infectious RD-114 virus in the vaccines by the LacZ marker rescue assay and PCR to detect proviral DNA in TE671 cells (human rhabdomyosarcoma cells) inoculated with the vaccines. It is impossible to investigate the definitive cause of contamination with RD-114 virus; however, we suspect that a seed canine parvovirus type 2 was contaminated with RD-114 virus, because many canine parvoviruses have been isolated and attenuated using feline cell lines. To exclude RD-114 virus from live attenuated vaccines, we must pay attention to the contamination of seed viruses with RD-114 virus in addition to avoiding feline cell lines producing RD-114 virus when manufacturing vaccines. Copyright © 2010 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

Microvascular resistance of the culprit coronary artery in acute ST-elevation myocardial infarction

PubMed Central

Carrick, David; Haig, Caroline; Carberry, Jaclyn; McCartney, Peter; Welsh, Paul; Ahmed, Nadeem; McEntegart, Margaret; Petrie, Mark C.; Eteiba, Hany; Lindsay, Mitchell; Hood, Stuart; Watkins, Stuart; Rauhalammi, Samuli M.O.; Mordi, Ify; Ford, Ian; Radjenovic, Aleksandra; Sattar, Naveed; Oldroyd, Keith G.

2016-01-01

BACKGROUND. Failed myocardial reperfusion is common and prognostically important after acute ST-elevation myocardial infarction (STEMI). The purpose of this study was to investigate coronary flow reserve (CFR), a measure of vasodilator capacity, and the index of microvascular resistance (IMR; mmHg × s) in the culprit artery of STEMI survivors. METHODS. IMR (n = 288) and CFR (n = 283; mean age [SD], 60 [12] years) were measured acutely using guide wire–based thermodilution. Cardiac MRI disclosed left ventricular pathology, function, and volumes at 2 days (n = 281) and 6 months after STEMI (n = 264). All-cause death or first heart failure hospitalization was independently adjudicated (median follow-up 845 days). RESULTS. Myocardial hemorrhage and microvascular obstruction occurred in 89 (42%) and 114 (54%) patients with evaluable T2*-MRI maps. IMR and CFR were associated with microvascular pathology (none vs. microvascular obstruction only vs. microvascular obstruction and myocardial hemorrhage) (median [interquartile range], IMR: 17 [12.0–33.0] vs. 17 [13.0–39.0] vs. 37 [21.0–63.0], P < 0.001; CFR: 1.7 [1.4–2.5] vs. 1.5 [1.1–1.8] vs. 1.4 [1.0–1.8], P < 0.001), whereas thrombolysis in myocardial infarction blush grade was not. IMR was a multivariable associate of changes in left ventricular end-diastolic volume (regression coefficient [95% CI] 0.13 [0.01, 0.24]; P = 0.036), whereas CFR was not (P = 0.160). IMR (5 units) was a multivariable associate of all-cause death or heart failure hospitalization (n = 30 events; hazard ratio [95% CI], 1.09 [1.04, 1.14]; P < 0.001), whereas CFR (P = 0.124) and thrombolysis in myocardial infarction blush grade (P = 0.613) were not. IMR had similar prognostic value for these outcomes as <50% ST-segment resolution on the ECG. CONCLUSIONS. IMR is more closely associated with microvascular pathology, left ventricular remodeling, and health outcomes than the angiogram or CFR. TRIAL REGISTRATION. NCT02072850. FUNDING. A British Heart Foundation Project Grant (PG/11/2/28474), the National Health Service, the Chief Scientist Office, a Scottish Funding Council Senior Fellowship, a British Heart Foundation Intermediate Fellowship (FS/12/62/29889), and a nonfinancial research agreement with Siemens Healthcare. PMID:27699259

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), works at a console during a Multi-Element Integrated Test (MEIT) of the U.S. Node 2 and the Japanese Experiment Module (JEM). Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), rests inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), rests inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi (right), with the National Space Development Agency of Japan (NASDA), is inside the Japanese Experiment Module (JEM), undergoing a Multi-Element Integrated Test (MEIT) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), signals success during a Multi-Element Integrated Test (MEIT ) of the Japanese Experiment Module (JEM) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

NASA Image and Video Library

2003-09-03

KENNEDY SPACE CENTER, FLA. - Astronaut Soichi Noguchi, with the National Space Development Agency of Japan (NASDA), signals success during a Multi-Element Integrated Test (MEIT ) of the Japanese Experiment Module (JEM) in the Space Station Processing Facility. Noguchi is assigned to mission STS-114 as a mission specialist. Node 2 attaches to the end of the U.S. Lab on the ISS and provides attach locations for the Japanese laboratory, European laboratory, the Centrifuge Accommodation Module and, eventually, Multipurpose Logistics Modules. It will provide the primary docking location for the Shuttle when a pressurized mating adapter is attached to Node 2. Installation of the module will complete the U.S. Core of the ISS. The JEM, developed by NASDA, is Japan's primary contribution to the Station. It will enhance the unique research capabilities of the orbiting complex by providing an additional environment for astronauts to conduct science experiments.

Development of Fine-Grained, Low-Carbon Bainitic Steels with High Strength and Toughness Produced Through the Conventional Hot-Rolling and Air-Cooling

NASA Astrophysics Data System (ADS)

Dhua, Sanjay Kumar; Sarkar, Partha Pratim; Saxena, Atul; Jha, Bimal Kumar

2016-12-01

Low-carbon bainitic steels have created enormous interest among scientists across the world in the past few decades because of their high strength, toughness, and weldability replacing the conventional quenched and tempered medium-carbon steels. Three experimental steels with varying alloy additions were made in a 100-kg laboratory induction furnace and cast into 100-mm-diameter cylindrical ingots. These ingots were hot-rolled and air-cooled to 6-mm plates in an experimental rolling mill with selected thermomechanical parameters. Steels processed through this process provided an ultrafine low-carbon bainitic microstructure with maximum yield strength (YS) and ultimate tensile strength (UTS) 575 and 705 MPa, respectively. The Charpy impact toughness of the experimental steels was excellent, and at 253 K (-20 °C), it varied from 114 to 170 Joules. Cu-B-added steel was found to give an optimum combination of strength, YS-575 MPa, and toughness, 114 J at 253 K (-20 °C). Thus, fine-grained, low-carbon bainitic steels could be developed with a proper combination of alloying elements and thermomechanical parameters even by air-cooling.

Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications.

PubMed

Otero, José Manuel; Vongsangnak, Wanwipa; Asadollahi, Mohammad A; Olivares-Hernandes, Roberto; Maury, Jérôme; Farinelli, Laurent; Barlocher, Loïc; Osterås, Magne; Schalk, Michel; Clark, Anthony; Nielsen, Jens

2010-12-22

The need for rapid and efficient microbial cell factory design and construction are possible through the enabling technology, metabolic engineering, which is now being facilitated by systems biology approaches. Metabolic engineering is often complimented by directed evolution, where selective pressure is applied to a partially genetically engineered strain to confer a desirable phenotype. The exact genetic modification or resulting genotype that leads to the improved phenotype is often not identified or understood to enable further metabolic engineering. In this work we performed whole genome high-throughput sequencing and annotation can be used to identify single nucleotide polymorphisms (SNPs) between Saccharomyces cerevisiae strains S288c and CEN.PK113-7D. The yeast strain S288c was the first eukaryote sequenced, serving as the reference genome for the Saccharomyces Genome Database, while CEN.PK113-7D is a preferred laboratory strain for industrial biotechnology research. A total of 13,787 high-quality SNPs were detected between both strains (reference strain: S288c). Considering only metabolic genes (782 of 5,596 annotated genes), a total of 219 metabolism specific SNPs are distributed across 158 metabolic genes, with 85 of the SNPs being nonsynonymous (e.g., encoding amino acid modifications). Amongst metabolic SNPs detected, there was pathway enrichment in the galactose uptake pathway (GAL1, GAL10) and ergosterol biosynthetic pathway (ERG8, ERG9). Physiological characterization confirmed a strong deficiency in galactose uptake and metabolism in S288c compared to CEN.PK113-7D, and similarly, ergosterol content in CEN.PK113-7D was significantly higher in both glucose and galactose supplemented cultivations compared to S288c. Furthermore, DNA microarray profiling of S288c and CEN.PK113-7D in both glucose and galactose batch cultures did not provide a clear hypothesis for major phenotypes observed, suggesting that genotype to phenotype correlations are manifested post-transcriptionally or post-translationally either through protein concentration and/or function. With an intensifying need for microbial cell factories that produce a wide array of target compounds, whole genome high-throughput sequencing and annotation for SNP detection can aid in better reducing and defining the metabolic landscape. This work demonstrates direct correlations between genotype and phenotype that provides clear and high-probability of success metabolic engineering targets. The genome sequence, annotation, and a SNP viewer of CEN.PK113-7D are deposited at http://www.sysbio.se/cenpk.

Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications

PubMed Central

2010-01-01

Background The need for rapid and efficient microbial cell factory design and construction are possible through the enabling technology, metabolic engineering, which is now being facilitated by systems biology approaches. Metabolic engineering is often complimented by directed evolution, where selective pressure is applied to a partially genetically engineered strain to confer a desirable phenotype. The exact genetic modification or resulting genotype that leads to the improved phenotype is often not identified or understood to enable further metabolic engineering. Results In this work we performed whole genome high-throughput sequencing and annotation can be used to identify single nucleotide polymorphisms (SNPs) between Saccharomyces cerevisiae strains S288c and CEN.PK113-7D. The yeast strain S288c was the first eukaryote sequenced, serving as the reference genome for the Saccharomyces Genome Database, while CEN.PK113-7D is a preferred laboratory strain for industrial biotechnology research. A total of 13,787 high-quality SNPs were detected between both strains (reference strain: S288c). Considering only metabolic genes (782 of 5,596 annotated genes), a total of 219 metabolism specific SNPs are distributed across 158 metabolic genes, with 85 of the SNPs being nonsynonymous (e.g., encoding amino acid modifications). Amongst metabolic SNPs detected, there was pathway enrichment in the galactose uptake pathway (GAL1, GAL10) and ergosterol biosynthetic pathway (ERG8, ERG9). Physiological characterization confirmed a strong deficiency in galactose uptake and metabolism in S288c compared to CEN.PK113-7D, and similarly, ergosterol content in CEN.PK113-7D was significantly higher in both glucose and galactose supplemented cultivations compared to S288c. Furthermore, DNA microarray profiling of S288c and CEN.PK113-7D in both glucose and galactose batch cultures did not provide a clear hypothesis for major phenotypes observed, suggesting that genotype to phenotype correlations are manifested post-transcriptionally or post-translationally either through protein concentration and/or function. Conclusions With an intensifying need for microbial cell factories that produce a wide array of target compounds, whole genome high-throughput sequencing and annotation for SNP detection can aid in better reducing and defining the metabolic landscape. This work demonstrates direct correlations between genotype and phenotype that provides clear and high-probability of success metabolic engineering targets. The genome sequence, annotation, and a SNP viewer of CEN.PK113-7D are deposited at http://www.sysbio.se/cenpk. PMID:21176163

UK114, a YjgF/Yer057p/UK114 family protein highly conserved from bacteria to mammals, is localized in rat liver peroxisomes.

PubMed

Antonenkov, Vasily D; Ohlmeier, Steffen; Sormunen, Raija T; Hiltunen, J Kalervo

2007-05-25

Mammalian UK114 belongs to a highly conserved family of proteins with unknown functions. Although it is believed that UK114 is a cytosolic or mitochondrial protein there is no detailed study of its intracellular localization. Using analytical subcellular fractionation, electron microscopic colloidal gold technique, and two-dimensional gel electrophoresis of peroxisomal matrix proteins combined with mass spectrometric analysis we show here that a large portion of UK114 is present in rat liver peroxisomes. The peroxisomal UK114 is a soluble matrix protein and it is not inducible by the peroxisomal proliferator clofibrate. The data predict involvement of UK114 in peroxisomal metabolism.

40 CFR 428.114 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false [Reserved] 428.114 Section 428.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS RUBBER MANUFACTURING POINT SOURCE CATEGORY Latex Foam Subcategory § 428.114 [Reserved] ...

40 CFR 428.114 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false [Reserved] 428.114 Section 428.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS RUBBER MANUFACTURING POINT SOURCE CATEGORY Latex Foam Subcategory § 428.114 [Reserved] ...

40 CFR 415.114 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 415.114 Section 415.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Metal Production Subcategory § 415.114...

40 CFR 415.114 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 30 2013-07-01 2012-07-01 true [Reserved] 415.114 Section 415.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Metal Production Subcategory § 415.114...

40 CFR 415.114 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 29 2011-07-01 2009-07-01 true [Reserved] 415.114 Section 415.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Metal Production Subcategory § 415.114...

40 CFR 415.114 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 30 2012-07-01 2012-07-01 false [Reserved] 415.114 Section 415.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Metal Production Subcategory § 415.114...

40 CFR 415.114 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 29 2014-07-01 2012-07-01 true [Reserved] 415.114 Section 415.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Metal Production Subcategory § 415.114...

Origin discrimination of defatted pork via trace elements profiling, stable isotope ratios analysis, and multivariate statistical techniques.

PubMed

Park, Yu Min; Lee, Cheong Mi; Hong, Joon Ho; Jamila, Nargis; Khan, Naeem; Jung, Jong-Hyun; Jung, Young-Chul; Kim, Kyong Su

2018-09-01

This study verified the origin of 346 defatted Korean and non-Korean pork samples via trace elements profiling, and C and N stable isotope ratios analysis. The analyzed elements were 6 Li, 7 Li, 10 B, 11 B, 51 V , 50 Cr, 52 Cr, 53 Cr, 55 Mn, 58 Ni, 60 Ni, 59 Co, 63 Cu, 65 Cu, 64 Zn, 66 Zn, 69 Ga, 71 Ga, 75 As, 82 Se, 84 Sr, 86 Sr, 87 Sr, 88 Sr, 85 Rb, 94 Mo, 95 Mo, 97 Mo, 107 Ag, 109 Ag, 110 Cd, 111 Cd, 113 Cd, 112 Cd, 114 Cd, 116 Cd, 133 Cs, 206 Pb, 207 Pb, and 208 Pb. Content (mg/kg) of 51 V (0.012), 50 Cr (0.882), 75 As (0.017), 85 Rb (57.7), and 87 Sr (46.3) were high in Korean pork samples whereas 6 Li, 7 Li, 59 Co, 55 Mn, 58 Ni, 84 Sr, 86 Sr, 88 Sr, 111 Cd, and 133 Cs were found higher in non-Korean samples. The results of discriminant analysis showed that the trace elements content and stable isotope ratios were significant for the discrimination of geographical origins with a perfect discrimination rate of 100%. Copyright © 2018 Elsevier Ltd. All rights reserved.

48 CFR 49.114 - Unsettled contract changes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Unsettled contract changes. 49.114 Section 49.114 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.114 Unsettled contract changes. (a) Before...

7 CFR 1150.114 - Promotion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Dairy Promotion and Research Order Definitions § 1150.114 Promotion. Promotion means actions such as paid advertising, sales... 7 Agriculture 9 2010-01-01 2009-01-01 true Promotion. 1150.114 Section 1150.114 Agriculture...

10 CFR 745.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Cooperative research. 745.114 Section 745.114 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.114 Cooperative research. Cooperative research... of cooperative research projects, each institution is responsible for safeguarding the rights and...

10 CFR 745.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Cooperative research. 745.114 Section 745.114 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.114 Cooperative research. Cooperative research... of cooperative research projects, each institution is responsible for safeguarding the rights and...

10 CFR 745.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Cooperative research. 745.114 Section 745.114 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.114 Cooperative research. Cooperative research... of cooperative research projects, each institution is responsible for safeguarding the rights and...

10 CFR 745.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Cooperative research. 745.114 Section 745.114 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.114 Cooperative research. Cooperative research... of cooperative research projects, each institution is responsible for safeguarding the rights and...

10 CFR 745.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Cooperative research. 745.114 Section 745.114 Energy DEPARTMENT OF ENERGY PROTECTION OF HUMAN SUBJECTS § 745.114 Cooperative research. Cooperative research... of cooperative research projects, each institution is responsible for safeguarding the rights and...

48 CFR 632.114 - Unusual contract financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Unusual contract financing. 632.114 Section 632.114 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Non-Commercial Item Purchase Financing 632.114 Unusual contract financing. The...

Presence of infectious RD-114 virus in a proportion of canine parvovirus isolates.

PubMed

Yoshikawa, Rokusuke; Sato, Eiji; Miyazawa, Takayuki

2012-03-01

We recently found that certain canine live attenuated vaccines produced using `non-feline' cell lines were contaminated with an infectious feline endogenous retrovirus, termed RD-114 virus. We suspected that RD-114 virus may have contaminated the seed stock of canine parvovirus (CPV) during the production of the contaminated vaccines. In this study, we collected stock viruses of CPVs propagated in a feline cell line, and checked the presence of infectious RD-114 virus. Consequently, we found that RD-114 viral RNA was present in all stock viruses, and 7 out of 18 stock viruses were contaminated with infectious RD-114 virus. We also found that RD-114 virus was stable physically and is capable of retaining its infectivity for a long period at -80°C.

20 CFR 498.114 - Collateral estoppel.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Collateral estoppel. 498.114 Section 498.114 Employees' Benefits SOCIAL SECURITY ADMINISTRATION CIVIL MONETARY PENALTIES, ASSESSMENTS AND RECOMMENDED EXCLUSIONS § 498.114 Collateral estoppel. In a proceeding under section 1129 of the Social Security Act that...

28 CFR 115.114 - Juveniles and youthful detainees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Juveniles and youthful detainees. 115.114 Section 115.114 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Prevention Planning § 115.114 Juveniles and youthful detainees...

28 CFR 115.114 - Juveniles and youthful detainees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Juveniles and youthful detainees. 115.114 Section 115.114 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Prevention Planning § 115.114 Juveniles and youthful detainees...

28 CFR 115.114 - Juveniles and youthful detainees.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Juveniles and youthful detainees. 115.114 Section 115.114 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Prevention Planning § 115.114 Juveniles and youthful detainees...

32 CFR 219.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

32 CFR 219.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

32 CFR 219.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

32 CFR 219.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

32 CFR 219.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare of...

34 CFR 101.114 - Expeditious treatment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Expeditious treatment. 101.114 Section 101.114 Education Regulations of the Offices of the Department of Education OFFICE FOR CIVIL RIGHTS, DEPARTMENT OF... § 101.114 Expeditious treatment. Requests for expeditious treatment of matters pending before the...

14 CFR 1240.114 - Delegation of authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Delegation of authority. 1240.114 Section 1240.114 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INVENTIONS AND CONTRIBUTIONS Awards for Scientific and Technical Contributions § 1240.114 Delegation of authority. (a) The...

42 CFR 66.114 - Copyright.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Copyright. 66.114 Section 66.114 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.114 Copyright. Where the work accomplished under an...

42 CFR 66.114 - Copyright.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Copyright. 66.114 Section 66.114 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.114 Copyright. Where the work accomplished under an...

42 CFR 66.114 - Copyright.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Copyright. 66.114 Section 66.114 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.114 Copyright. Where the work accomplished under an...

42 CFR 66.114 - Copyright.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Copyright. 66.114 Section 66.114 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.114 Copyright. Where the work accomplished under an...

42 CFR 66.114 - Copyright.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Copyright. 66.114 Section 66.114 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL RESEARCH SERVICE AWARDS Direct Awards § 66.114 Copyright. Where the work accomplished under an...

7 CFR 457.114-457.115 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false [Reserved] 457.114-457.115 Section 457.114-457.115 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS §§ 457.114-457.115 [Reserved] ...

76 FR 7570 - Proposed Collection; Comment Request; National Institutes of Health Loan Repayment Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

...In compliance with the requirement of Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, for opportunity for public comment on proposed data collection projects, the Division of Loan Repayment, National Institutes of Health (NIH), will publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed Collection: Title: National Institutes of Health Loan Repayment Programs. Type of Information Collection Request: Extension of a currently approved collection (OMB No. 0925-0361, expiration date 06/30/11). Form Numbers: NIH 2674-1, NIH 2674-2, NIH 2674-3, NIH 2674- 4, NIH 2674-5, NIH 2674-6, NIH 2674-7, NIH 2674-8, NIH 2674-9, NIH 2674-10, NIH 2674-11, NIH 2674-12, NIH 2674-13, NIH 2674-14, NIH 2674- 15, NIH 2674-16, NIH 2674-17, NIH 2674-18, and NIH 2674-19. Need and Use of Information Collection: The NIH makes available financial assistance, in the form of educational loan repayment, to M.D., PhD, Pharm.D., D.D.S., D.M.D., D.P.M., D.C., and N.D. degree holders, or the equivalent, who perform biomedical or behavioral research in NIH intramural laboratories or as extramural grantees or scientists funded by domestic nonprofit organizations for a minimum of 2 years (3 years for the General Research Loan Repayment Program (LRP)) in research areas supporting the mission and priorities of the NIH. The AIDS Research LRP (AIDS-LRP) is authorized by section 487A of the Public Health Service Act (PHS Act) (42 U.S.C. 288-1), and the Clinical Research LRP for Individuals from Disadvantaged Backgrounds (CR-LRP) is authorized by section 487E (42 U.S.C. 288-5). The General Research LRP (GR-LRP) is authorized by section 487C of the PHS Act (42 U.S.C. 288-3), and the Clinical Research LRP (LRP-CR) is authorized by section 487F (42 U.S.C. 288-5a). The Pediatric Research LRP (PR-LRP) is authorized by section 487F of the PHS Act (42 U.S.C. 288-6), and the Extramural Clinical Research LRP for Individuals from Disadvantaged Backgrounds (ECR-LRP) is authorized by an amendment to section 487E (42 U.S.C. 288-5). The Contraception and Infertility Research LRP (CIR-LRP) is authorized by section 487B of the PHS Act (42 U.S.C. 288-2), and the Health Disparities Research LRP (HD- LRP) is authorized by section 485G (42 U.S.C. 287c-33). The Loan Repayment Programs can repay up to $35,000 per year toward a participant's extant eligible educational loans, directly to financial institutions. The information proposed for collection will be used by the Division of Loan Repayment to determine an applicant's eligibility for participation in the program. Frequency of Response: Initial application and one- or two-year renewal application. Affected Public: Individuals or households, nonprofits, and businesses or other for-profit. Type of Respondents: Physicians, other scientific or medical personnel, and institutional representatives. The annual reporting burden is as follows:

14 CFR 1245.114 - Findings and recommendations of the Board.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Findings and recommendations of the Board. 1245.114 Section 1245.114 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.114 Findings and...

14 CFR 1245.114 - Findings and recommendations of the Board.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Findings and recommendations of the Board. 1245.114 Section 1245.114 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.114 Findings and...

42 CFR 1003.114 - Collateral estoppel.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Collateral estoppel. 1003.114 Section 1003.114 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES CIVIL MONEY PENALTIES, ASSESSMENTS AND EXCLUSIONS § 1003.114 Collateral estoppel. (a) Where a...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates...

11 CFR 114.8 - Trade associations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 11 Federal Elections 1 2014-01-01 2014-01-01 false Trade associations. 114.8 Section 114.8 Federal Elections FEDERAL ELECTION COMMISSION GENERAL CORPORATE AND LABOR ORGANIZATION ACTIVITY § 114.8 Trade associations. (a) Definition. A trade association is generally a membership organization of persons engaging in...

11 CFR 114.8 - Trade associations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 11 Federal Elections 1 2013-01-01 2012-01-01 true Trade associations. 114.8 Section 114.8 Federal Elections FEDERAL ELECTION COMMISSION GENERAL CORPORATE AND LABOR ORGANIZATION ACTIVITY § 114.8 Trade associations. (a) Definition. A trade association is generally a membership organization of persons engaging in...

11 CFR 114.8 - Trade associations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 11 Federal Elections 1 2011-01-01 2011-01-01 false Trade associations. 114.8 Section 114.8 Federal Elections FEDERAL ELECTION COMMISSION GENERAL CORPORATE AND LABOR ORGANIZATION ACTIVITY § 114.8 Trade associations. (a) Definition. A trade association is generally a membership organization of persons engaging in...

11 CFR 114.8 - Trade associations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 11 Federal Elections 1 2012-01-01 2012-01-01 false Trade associations. 114.8 Section 114.8 Federal Elections FEDERAL ELECTION COMMISSION GENERAL CORPORATE AND LABOR ORGANIZATION ACTIVITY § 114.8 Trade associations. (a) Definition. A trade association is generally a membership organization of persons engaging in...

45 CFR 690.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Cooperative research. 690.114 Section 690.114... OF HUMAN SUBJECTS § 690.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research...

21 CFR 56.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Cooperative research. 56.114 Section 56.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL INSTITUTIONAL REVIEW BOARDS IRB Functions and Operations § 56.114 Cooperative research. In complying with these...

45 CFR 690.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Cooperative research. 690.114 Section 690.114... OF HUMAN SUBJECTS § 690.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research...

21 CFR 56.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Cooperative research. 56.114 Section 56.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL INSTITUTIONAL REVIEW BOARDS IRB Functions and Operations § 56.114 Cooperative research. In complying with these...

21 CFR 56.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Cooperative research. 56.114 Section 56.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL INSTITUTIONAL REVIEW BOARDS IRB Functions and Operations § 56.114 Cooperative research. In complying with these...

45 CFR 690.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Cooperative research. 690.114 Section 690.114... OF HUMAN SUBJECTS § 690.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research...

21 CFR 56.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Cooperative research. 56.114 Section 56.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL INSTITUTIONAL REVIEW BOARDS IRB Functions and Operations § 56.114 Cooperative research. In complying with these...

45 CFR 690.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Cooperative research. 690.114 Section 690.114... OF HUMAN SUBJECTS § 690.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research...

45 CFR 690.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Cooperative research. 690.114 Section 690.114... OF HUMAN SUBJECTS § 690.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research...

21 CFR 56.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Cooperative research. 56.114 Section 56.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL INSTITUTIONAL REVIEW BOARDS IRB Functions and Operations § 56.114 Cooperative research. In complying with these...

29 CFR 779.114 - Transportation employees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Transportation employees. 779.114 Section 779.114 Labor... Coverage Employees Engaged in Commerce Or in the Production of Goods for Commerce § 779.114 Transportation employees. Transportation employees of retail businesses, such as truck drivers or truck drivers' helpers...

10 CFR 1304.114 - Responsibility for maintaining adequate safeguards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Responsibility for maintaining adequate safeguards. 1304.114 Section 1304.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.114 Responsibility for maintaining adequate safeguards. The Board has the responsibility for maintaining adequate...

10 CFR 1304.114 - Responsibility for maintaining adequate safeguards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Responsibility for maintaining adequate safeguards. 1304.114 Section 1304.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.114 Responsibility for maintaining adequate safeguards. The Board has the responsibility for maintaining adequate...

10 CFR 1304.114 - Responsibility for maintaining adequate safeguards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Responsibility for maintaining adequate safeguards. 1304.114 Section 1304.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.114 Responsibility for maintaining adequate safeguards. The Board has the responsibility for maintaining adequate...

10 CFR 1304.114 - Responsibility for maintaining adequate safeguards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Responsibility for maintaining adequate safeguards. 1304.114 Section 1304.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.114 Responsibility for maintaining adequate safeguards. The Board has the responsibility for maintaining adequate...

29 CFR 779.114 - Transportation employees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Transportation employees. 779.114 Section 779.114 Labor... Coverage Employees Engaged in Commerce Or in the Production of Goods for Commerce § 779.114 Transportation employees. Transportation employees of retail businesses, such as truck drivers or truck drivers' helpers...

29 CFR 779.114 - Transportation employees.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Transportation employees. 779.114 Section 779.114 Labor... Coverage Employees Engaged in Commerce Or in the Production of Goods for Commerce § 779.114 Transportation employees. Transportation employees of retail businesses, such as truck drivers or truck drivers' helpers...

29 CFR 779.114 - Transportation employees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Transportation employees. 779.114 Section 779.114 Labor... Coverage Employees Engaged in Commerce Or in the Production of Goods for Commerce § 779.114 Transportation employees. Transportation employees of retail businesses, such as truck drivers or truck drivers' helpers...

29 CFR 779.114 - Transportation employees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Transportation employees. 779.114 Section 779.114 Labor... Coverage Employees Engaged in Commerce Or in the Production of Goods for Commerce § 779.114 Transportation employees. Transportation employees of retail businesses, such as truck drivers or truck drivers' helpers...

21 CFR 114.100 - Records.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Records. 114.100 Section 114.100 Food and Drugs... CONSUMPTION ACIDIFIED FOODS Records and Reports § 114.100 Records. (a) Records shall be maintained of... action levels. (b) Processing and production records showing adherence to scheduled processes, including...

21 CFR 114.100 - Records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Records. 114.100 Section 114.100 Food and Drugs... CONSUMPTION ACIDIFIED FOODS Records and Reports § 114.100 Records. (a) Records shall be maintained of... action levels. (b) Processing and production records showing adherence to scheduled processes, including...

21 CFR 114.100 - Records.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Records. 114.100 Section 114.100 Food and Drugs... CONSUMPTION ACIDIFIED FOODS Records and Reports § 114.100 Records. (a) Records shall be maintained of... action levels. (b) Processing and production records showing adherence to scheduled processes, including...

Lipidomic profile in three species of dinoflagellates (Amphidinium carterae, Cystodinium sp., and Peridinium aciculiferum) containing very long chain polyunsaturated fatty acids.

PubMed

Řezanka, Tomáš; Lukavský, Jaromír; Nedbalová, Linda; Sigler, Karel

2017-07-01

This study describes the identification of very long chain polyunsaturated fatty acids (VLCPUFAs) in three strains of dinoflagellates (Amphidinium carterae, Cystodinium sp., and Peridinium aciculiferum). The strains were cultivated and their lipidomic profiles were obtained by high resolution mass spectrometry with the aid of positive and negative electrospray ionization (ESI) mode by Orbitrap apparatus. Hydrophilic interaction liquid chromatography (HILIC/ESI) was used to separate major lipid classes of the three genera of dinoflagellates by neutral loss scan showing the ion [M + H-28:8] + , where 28:8 was octacosaoctaenoic acid, and by precursor ion scanning of ions at m/z 407, which was an ion corresponding to the structure of acyl of 28:8 acid (C 27 H 39 COO - ). Based on these analyzes, it was found that out of more than a dozen lipid classes present in the total lipids, only two classes of neutral lipids, i.e. major triacylglycerols and minor diacylglycerols contain VLCPUFAs. In polar lipids, VLCPUFAs were identified only in phosphatidic acid (PA) and phosphatidyl choline (PC) or in their lyso-forms (LPA and LPC). Further analysis of individual lipid classes by reversed-phase high-performance liquid chromatography (RP-HPLC) showed the presence of triacylglycerols (TAGs) containing VLCPUFAs, i.e. molecular species of the sn-28:7/28:8/28:8, sn-26:7/28:7/28:8, or sn-26:7/28:8/28:8 types. These TAGs are the longest and most unsaturated TAGs isolated from a natural source that have yet been synthesized. In the case of PA and PC, tandem MS identified sn-28:8/16:0-PA and sn-28:8/16:0-PC and the corresponding lyso-forms (28:8-LPC and 28:8-LPA). All these results indicate that TAGs containing VLCPUFAs are biosynthesized in dinoflagellates in the same manner as in higher eukaryotic organisms, which means that the PA, after conversion to DAG, serves as a precursor in the biosynthesis of other phospholipids, e.g. PC, and, after further acylation, also of TAG. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Reactivations of Main-Belt Comets 238P/READ, 259P/Garradd, and 288P/(300163) 2006 VW139

NASA Astrophysics Data System (ADS)

Hsieh, Henry H.; Ishiguro, Masateru; Kim, Yoonyoung; Knight, Matthew M.; Lin, Zhong-Yi; Micheli, Marco; Moskovitz, Nicholas; Sheppard, Scott S.; Thirouin, Audrey; Trujillo, Chadwick

2017-10-01

We report on the confirmation and monitoring of recurrent activity for main-belt comets (MBCs) 238P/Read and 288P/(300163) 2006 VW139 in 2016 (cf. Agarwal et al. 2016, CBET 4306; Hsieh et al. 2016, CBET 4307), as well as the identification of activity for 288P in Sloan Digital Sky Survey images from November 2000. We will also report on the confirmation of recurrent activity in 2017 (Hsieh et al. 2017, CBET 4388) and the progress of the ongoing monitoring campaign (April 2017 through December 2017) that we are conducting for MBC 259P/Garradd. With these observations, 238P and 288P have now each been observed to be active on three separate orbit passages with intervening periods of inactivity and 259P has been observed to be active on two separate orbit passages, firmly establishing the cometary (i.e., sublimation-driven) nature of their activity. We are currently conducting a multi-facility observing campaign to monitor the photometric and morphological evolution of these objects, using the Canada-France-Hawaii Telescope, the Gemini North and South telescopes (under a Gemini Large and Long Program), the Magellan telescopes, the Discovery Channel Telescope, and the Lulin One-meter Telescope. During their most recent perihelion encounters, 238P was observed to be active as early as 2016 July 8 at a true anomaly of 329 degrees, 288P was observed to be active as early as 2016 June 8 at a true anomaly of 318 degrees, and 259P was observed to be active as early at 2017 April 26 at a true anomaly of 315 degrees. We also report on the results of numerical modeling analyses of the morphological evolution of all three objects aimed at assessing both the properties of their current active episodes and changes in activity strength from one epoch to the next to help constrain the active lifetimes of MBCs, a key parameter for inferring the total number of MBCs in the asteroid belt from survey results. This work was supported by the NASA Solar System Observations program under Grant NNX16AD68G.

1 CFR 11.4 - The United States Government Manual.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 1 General Provisions 1 2011-01-01 2011-01-01 false The United States Government Manual. 11.4 Section 11.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.4 The United States Government Manual. Copies of...

1 CFR 11.4 - The United States Government Manual.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false The United States Government Manual. 11.4 Section 11.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.4 The United States Government Manual. Copies of...

10 CFR 1304.114 - Responsibility for maintaining adequate safeguards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the security and privacy of personal data. (4) The disposal and disposition of identifiable personal... contained in a system of records are adequately trained to protect the security and privacy of such records....114 Section 1304.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PRIVACY ACT OF 1974 § 1304.114...

19 CFR § 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2018-04-01

... 19 Customs Duties 1 2018-04-01 2018-04-01 false Contents. § 122.114 Section § 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form...

29 CFR 780.114 - Wild commodities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Agricultural Or Horticultural Commodities § 780.114 Wild commodities. Employees engaged in the gathering or harvesting of wild commodities such as mosses, wild rice, burls and laurel plants, the trapping of wild... 29 Labor 3 2013-07-01 2013-07-01 false Wild commodities. 780.114 Section 780.114 Labor Regulations...

29 CFR 780.114 - Wild commodities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Agricultural Or Horticultural Commodities § 780.114 Wild commodities. Employees engaged in the gathering or harvesting of wild commodities such as mosses, wild rice, burls and laurel plants, the trapping of wild... 29 Labor 3 2011-07-01 2011-07-01 false Wild commodities. 780.114 Section 780.114 Labor Regulations...

29 CFR 780.114 - Wild commodities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Agricultural Or Horticultural Commodities § 780.114 Wild commodities. Employees engaged in the gathering or harvesting of wild commodities such as mosses, wild rice, burls and laurel plants, the trapping of wild... 29 Labor 3 2014-07-01 2014-07-01 false Wild commodities. 780.114 Section 780.114 Labor Regulations...

29 CFR 780.114 - Wild commodities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Agricultural Or Horticultural Commodities § 780.114 Wild commodities. Employees engaged in the gathering or harvesting of wild commodities such as mosses, wild rice, burls and laurel plants, the trapping of wild... 29 Labor 3 2010-07-01 2010-07-01 false Wild commodities. 780.114 Section 780.114 Labor Regulations...

29 CFR 780.114 - Wild commodities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Agricultural Or Horticultural Commodities § 780.114 Wild commodities. Employees engaged in the gathering or harvesting of wild commodities such as mosses, wild rice, burls and laurel plants, the trapping of wild... 29 Labor 3 2012-07-01 2012-07-01 false Wild commodities. 780.114 Section 780.114 Labor Regulations...

1 CFR 11.4 - The United States Government Manual.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true The United States Government Manual. 11.4 Section 11.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.4 The United States Government Manual. (a) The...

1 CFR 11.4 - The United States Government Manual.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true The United States Government Manual. 11.4 Section 11.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.4 The United States Government Manual. (a) The...

14 CFR 1215.114 - Service rates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Service rates. 1215.114 Section 1215.114 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION TRACKING AND DATA RELAY SATELLITE SYSTEM (TDRSS) Use and Reimbursement Policy for Non-U.S. Government Users § 1215.114 Service rates. (a) Non-U.S...

21 CFR 114.90 - Methodology.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Methodology. 114.90 Section 114.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.90 Methodology. Methods that may be used to...

21 CFR 114.90 - Methodology.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Methodology. 114.90 Section 114.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.90 Methodology. Methods that may be used to...

21 CFR 114.90 - Methodology.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Methodology. 114.90 Section 114.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION ACIDIFIED FOODS Production and Process Controls § 114.90 Methodology. Methods that may be used to...

11 CFR 1.14 - Specific exemptions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... to refer apparent violations of the Act to the Attorney General or other law enforcement authorities... 11 Federal Elections 1 2010-01-01 2010-01-01 false Specific exemptions. 1.14 Section 1.14 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.14 Specific exemptions. (a) No individual, under the...

19 CFR 148.114 - Shipment of unaccompanied articles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 2 2013-04-01 2013-04-01 false Shipment of unaccompanied articles. 148.114 Section 148.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... States § 148.114 Shipment of unaccompanied articles. One copy of the validated Customs Form 255 shall be...

19 CFR 148.114 - Shipment of unaccompanied articles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 2 2011-04-01 2011-04-01 false Shipment of unaccompanied articles. 148.114 Section 148.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... States § 148.114 Shipment of unaccompanied articles. One copy of the validated Customs Form 255 shall be...

19 CFR 148.114 - Shipment of unaccompanied articles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 2 2014-04-01 2014-04-01 false Shipment of unaccompanied articles. 148.114 Section 148.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... States § 148.114 Shipment of unaccompanied articles. One copy of the validated Customs Form 255 shall be...

19 CFR 148.114 - Shipment of unaccompanied articles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 2 2012-04-01 2012-04-01 false Shipment of unaccompanied articles. 148.114 Section 148.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... States § 148.114 Shipment of unaccompanied articles. One copy of the validated Customs Form 255 shall be...

19 CFR 148.114 - Shipment of unaccompanied articles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Shipment of unaccompanied articles. 148.114 Section 148.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... States § 148.114 Shipment of unaccompanied articles. One copy of the validated Customs Form 255 shall be...

19 CFR § 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2015-04-01

... 19 Customs Duties 1 2015-04-01 2015-04-01 false Contents. § 122.114 Section § 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form...

7 CFR 1c.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Cooperative research. 1c.114 Section 1c.114 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one...

7 CFR 1c.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Cooperative research. 1c.114 Section 1c.114 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

45 CFR 46.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Cooperative research. 46.114 Section 46.114 Public... HHS Policy for Protection of Human Research Subjects § 46.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the...

45 CFR 46.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Cooperative research. 46.114 Section 46.114 Public... HHS Policy for Protection of Human Research Subjects § 46.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the...

7 CFR 1c.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Cooperative research. 1c.114 Section 1c.114 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one...

45 CFR 46.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Cooperative research. 46.114 Section 46.114 Public... HHS Policy for Protection of Human Research Subjects § 46.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the...

7 CFR 1c.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Cooperative research. 1c.114 Section 1c.114 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

45 CFR 46.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Cooperative research. 46.114 Section 46.114 Public... HHS Policy for Protection of Human Research Subjects § 46.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the...

45 CFR 46.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Cooperative research. 46.114 Section 46.114 Public... HHS Policy for Protection of Human Research Subjects § 46.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the...

7 CFR 1c.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Cooperative research. 1c.114 Section 1c.114 Agriculture Office of the Secretary of Agriculture PROTECTION OF HUMAN SUBJECTS § 1c.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

34 CFR 97.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false Cooperative research. 97.114 Section 97.114 Education... Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than...

7 CFR 1260.114 - Eligible organization.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Eligible organization. 1260.114 Section 1260.114... Promotion and Research Order Definitions § 1260.114 Eligible organization. Eligible organization means any organization which has been certified by the Secretary pursuant to the Act and this part as being eligible to...

7 CFR 1160.114 - Eligible organization.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Eligible organization. 1160.114 Section 1160.114... Order Definitions § 1160.114 Eligible organization. Eligible organization means an organization eligible... organization pursuant to section 501(c) (3), (5), or (6) of the Internal Revenue Code (26 U.S.C. 501(c) (3), (5...

7 CFR 11.4 - Other laws and regulations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Other laws and regulations. 11.4 Section 11.4 Agriculture Office of the Secretary of Agriculture NATIONAL APPEALS DIVISION National Appeals Divison Rules of Procedures § 11.4 Other laws and regulations. (a) The provisions of the Administrative Procedure Act...

33 CFR 114.50 - Right of appeal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Right of appeal. 114.50 Section 114.50 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES GENERAL § 114.50 Right of appeal. A District Commander's decision to deny a bridge permit application or an...

21 CFR 146.114 - Lemon juice.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Lemon juice. 146.114 Section 146.114 Food and....114 Lemon juice. (a) Identity—(1) Description. Lemon juice is the unfermented juice, obtained by mechanical process, from sound, mature lemons (Citrus limon (L.) Burm. f.), from which seeds (except...

7 CFR 11.4 - Other laws and regulations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Other laws and regulations. 11.4 Section 11.4 Agriculture Office of the Secretary of Agriculture NATIONAL APPEALS DIVISION National Appeals Divison Rules of Procedures § 11.4 Other laws and regulations. (a) The provisions of the Administrative Procedure Act...

10 CFR 1303.114 - Appeals.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Appeals. 1303.114 Section 1303.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.114 Appeals. (a)(1) Appeals of adverse... Executive Director: (i) By mail to: U.S. Nuclear Waste Technical Review Board, 2300 Clarendon Boulevard...

10 CFR 1303.114 - Appeals.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Appeals. 1303.114 Section 1303.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.114 Appeals. (a)(1) Appeals of adverse... Executive Director: (i) By mail to: U.S. Nuclear Waste Technical Review Board, 2300 Clarendon Boulevard...

10 CFR 1303.114 - Appeals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Appeals. 1303.114 Section 1303.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.114 Appeals. (a)(1) Appeals of adverse... Executive Director: (i) By mail to: U.S. Nuclear Waste Technical Review Board, 2300 Clarendon Boulevard...

10 CFR 1303.114 - Appeals.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Appeals. 1303.114 Section 1303.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.114 Appeals. (a)(1) Appeals of adverse... Executive Director: (i) By mail to: U.S. Nuclear Waste Technical Review Board, 2300 Clarendon Boulevard...

10 CFR 1303.114 - Appeals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Appeals. 1303.114 Section 1303.114 Energy NUCLEAR WASTE TECHNICAL REVIEW BOARD PUBLIC INFORMATION AND REQUESTS § 1303.114 Appeals. (a)(1) Appeals of adverse... Executive Director: (i) By mail to: U.S. Nuclear Waste Technical Review Board, 2300 Clarendon Boulevard...

7 CFR 905.114 - Redistricting of citrus districts and reapportionment of grower members.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Redistricting of citrus districts and reapportionment of grower members. 905.114 Section 905.114 Agriculture Regulations of the Department of Agriculture... Regulations § 905.114 Redistricting of citrus districts and reapportionment of grower members. Pursuant to...

7 CFR 905.114 - Redistricting of citrus districts and reapportionment of grower members.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 8 2011-01-01 2011-01-01 false Redistricting of citrus districts and reapportionment of grower members. 905.114 Section 905.114 Agriculture Regulations of the Department of Agriculture... Regulations § 905.114 Redistricting of citrus districts and reapportionment of grower members. Pursuant to...

21 CFR 133.114 - Cheddar cheese for manufacturing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Cheddar cheese for manufacturing. 133.114 Section 133.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Standardized Cheese and Related Products § 133.114 Cheddar cheese for manufacturing. Cheddar cheese for...

7 CFR 760.114 - Minors.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 7 2011-01-01 2011-01-01 false Minors. 760.114 Section 760.114 Agriculture... Assistance Programs § 760.114 Minors. A minor child is eligible to apply for program benefits under ELAP, LFP, LIP, SURE, or TAP if all the eligibility requirements are met and the provision for minor children in...

7 CFR 760.114 - Minors.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Minors. 760.114 Section 760.114 Agriculture... Assistance Programs § 760.114 Minors. A minor child is eligible to apply for program benefits under ELAP, LFP, LIP, SURE, or TAP if all the eligibility requirements are met and the provision for minor children in...

29 CFR 2570.114 - Consequences of default.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.114 Section 2570.114 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(6) § 2570.114 Consequences of default. For 502(c)(6) civil penalty proceedings...

32 CFR 643.114 - Civil disturbances.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Civil disturbances. 643.114 Section 643.114... ESTATE Additional Authority of Commanders § 643.114 Civil disturbances. Without reference to higher... facilities during civil disturbance for not more than 30 days to the National Guard and to municipal, county...

32 CFR 643.114 - Civil disturbances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Civil disturbances. 643.114 Section 643.114... ESTATE Additional Authority of Commanders § 643.114 Civil disturbances. Without reference to higher... facilities during civil disturbance for not more than 30 days to the National Guard and to municipal, county...

32 CFR 643.114 - Civil disturbances.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 4 2014-07-01 2013-07-01 true Civil disturbances. 643.114 Section 643.114... ESTATE Additional Authority of Commanders § 643.114 Civil disturbances. Without reference to higher... facilities during civil disturbance for not more than 30 days to the National Guard and to municipal, county...

32 CFR 643.114 - Civil disturbances.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 4 2012-07-01 2011-07-01 true Civil disturbances. 643.114 Section 643.114... ESTATE Additional Authority of Commanders § 643.114 Civil disturbances. Without reference to higher... facilities during civil disturbance for not more than 30 days to the National Guard and to municipal, county...

32 CFR 643.114 - Civil disturbances.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 4 2013-07-01 2013-07-01 false Civil disturbances. 643.114 Section 643.114... ESTATE Additional Authority of Commanders § 643.114 Civil disturbances. Without reference to higher... facilities during civil disturbance for not more than 30 days to the National Guard and to municipal, county...

Histologic work-up of non-palpable breast lesions classified as probably benign at initial mammography and/or ultrasound (BI-RADS category 3).

PubMed

Gruber, R; Jaromi, S; Rudas, M; Pfarl, G; Riedl, C C; Flöry, D; Graf, O; Sickles, E A; Helbich, T H

2013-03-01

To determine the accuracy of a probably benign assessment of non-palpable breast lesions (BI-RADS category 3) at mammography and/or ultrasound with immediate histological work-up. Stereotactic or ultrasound guided core needle breast biopsy (NBB) was performed to evaluate 288 lesions, which were prospectively assessed as BI-RADS category 3. Imaging findings included 195 masses, 73 calcification cases, 16 focal asymmetries, and four architectural distortion cases. After NBB, patients underwent either open surgical biopsy (OSB) (n=204) or mammographic follow-up (n=84) for at least 24 months. Histological results of NBB were compared with those of OSB. Three of the 288 lesions (1.0%) proved to be malignant at histological work-up, two of them were ductal carcinoma in situ (DCIS) and one of them was an invasive carcinoma. NBB revealed invasive carcinoma in 1/288 (0.35%) and atypical ductal hyperplasia (ADH) in 13/288 (4.5%) lesions. OSB revealed DCIS in 2/204 (1%) and invasive carcinoma in 1/204 (0.5%) lesions. The two DCIS were underestimated as ADH by NBB. The remaining 285 (99%) lesions proved to be benign at OSB or remained stable during follow-up. Confirmed by tissue diagnosis, the low likelihood of malignancy of prospectively assessed probably benign lesions is below the 2% threshold established for BI-RADS category 3. Imaging follow-up is a safe and effective alternative to immediate histological work-up for such lesions. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Solid-liquid phase equilibria in the ternary system (LiBO2 + Li2CO3 + H2O) at 288.15 and 298.15 K

NASA Astrophysics Data System (ADS)

Wang, Shi-qiang; Guo, Ya-fei; Yang, Jian-sen; Deng, Tian-long

2015-12-01

Experimental studies on the solubilities and physicochemical properties including density, refractive index and pH value in the ternary systems (LiBO2 + Li2CO3 + H2O) at 288.15 and 298.15 K were determined with the method of isothermal dissolution equilibrium. Based on the experimental results, the phase diagrams and their corresponding physicochemical properties versus composition diagram in the system were plotted. In the phase diagrams of the ternary system at 288.15 and 298.15 K, there are one eutectic point and two crystallization regions corresponding to lithium metaborate octahydrate (LiBO2 · 8H2O) and lithium carbonate (Li2CO3), respectively. This system at both temperatures belongs to hydrate type I, and neither double salt nor solid solution was found. A comparison of the phase diagrams for this ternary system at 288.15 and 298.15 K shows that the solid phase numbers and exist minerals are the same, and the area of crystallization region of Li2CO3 is increased obviously with the increasing temperature while that of LiBO2 · 8H2O is decreased. The physicochemical properties (density, pH value and refractive index) of the solutions of the ternary system at two temperatures changes regularly with the increasing lithium carbonate concentration. The calculated values of density and refractive index using empirical equations of the ternary system are in good agreement with the experimental values.

Lung volumes, pulmonary ventilation, and hypoxia following rapid decompression to 60,000 ft (18,288 m).

PubMed

Connolly, Desmond M; D'Oyly, Timothy J; McGown, Amanda S; Lee, Vivienne M

2013-06-01

Rapid decompressions (RD) to 60,000 ft (18,288 m) were undertaken by six subjects to provide evidence of satisfactory performance of a contemporary, partial pressure assembly life support system for the purposes of flight clearance. A total of 12 3-s RDs were conducted with subjects breathing 56% oxygen (balance nitrogen) at the base (simulated cabin) altitude of 22,500 ft (6858 m), switching to 100% oxygen under 72 mmHg (9.6 kPa) of positive pressure at the final (simulated aircraft) altitude. Respiratory pressures, flows, and gas compositions were monitored continuously throughout. All RDs were completed safely, but one subject experienced significant hypoxia during the minute at final altitude, associated with severe hemoglobin desaturation to a low of 53%. Accurate data on subjects' lung volumes were obtained and individual responses post-RD were reviewed in relation to patterns of pulmonary ventilation. The occurrence of severe hypoxia is explained by hypoventilation in conjunction with unusually large lung volumes (total lung capacity 10.18 L). Subjects' lung volumes and patterns of pulmonary ventilation are critical, but idiosyncratic, determinants of alveolar oxygenation and severity of hypoxia following RD to 60,000 ft (18,288 m). At such extreme altitudes even vaporization of water condensate in the oxygen mask may compromise oxygen delivery. An altitude ceiling of 60,000 ft (18,288 m) is the likely threshold for reliable protection using partial pressure assemblies and aircrew should be instructed to take two deep 'clearing' breaths immediately following RD at such extreme pressure breathing altitudes.

Smoking cessation interventions in the pre-admission clinic: assessing two approaches.

PubMed

Sachs, Robyn; Wild, T Cameron; Thomas, Laura; Hammal, Fadi; Finegan, Barry A

2012-07-01

Brief intervention (BI) to encourage patients who smoke to quit is effective and should occur at every patient interaction. If smokers receive a motivational interview in addition to BI and are offered pharmacotherapy to treat nicotine withdrawal, cessation rates may be improved. We compared the uptake, implementation, and effectiveness of these two approaches in the delivery of a smoking cessation intervention during assessments in a pre-admission clinic (PAC). The study was performed in the PAC at two tertiary care hospitals. At both hospitals, PAC patients were screened for smoking status, and current smokers were offered the opportunity to participate in a cessation program. Those who agreed were asked to consent to participate in an evaluation of program effectiveness that included a telephone interview about smoking status six months after hospital discharge. A cohort design was used to compare cessation outcomes across PACs during a one-year period of patient recruitment. The primary outcome measure was a self-reported continuous quit rate six months following hospitalization. Secondary outcomes included the number of patients willing to participate and the completeness of the delivery of program components. A BI delivered at one PAC consisted of brief advice and self-help materials, including handing the patient a business card with an available 1-800 Quit line (a telephone smoking cessation help line). The other PAC offered an intensive intervention (II) that included augmenting the BI with an in-hospital and post-discharge motivational interview and access to nicotine replacement therapy (NRT) during admission. At follow-up, we were able to contact 147 of the 288 smokers who agreed to participate in the evaluation of the program, and the self-reported quit rates for the BI and II interventions were 11.4% and 19.5%, respectively. More than 1,200 current smokers were identified and approached at both PACs during the 12-month patient recruitment period, and 60% of those were willing to accept the offered smoking cessation intervention (either BI or II). Implementation of II was uneven, particularly the delivery of the in-hospital motivational interview and prescription of NRT. Uptake of the 1-800 Quit service after discharge was inadequate. The PAC is a feasible location to identify smokers and offer a cessation intervention. There are considerable logistical barriers to the development of an II intervention program as described. A program that incorporates elements of BI and II could offer a practical approach to the implementation of a hospital-wide smoking cessation intervention.

78 FR 60698 - Safety Zone, Lucas Oil Drag Boat Racing Series; Thompson Bay, Lake Havasu City, AZ.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

...]26'51.99'' N, 114[deg]21'03.83'' W South Zone Line: 34[deg]27'07.99'' N, 114[deg]21'09.93'' W 34[deg]26'51.99'' N, 114[deg]21'03.83'' W This safety zone is necessary to ensure personnel and vessels...]21'09.93'' W 34[deg]26'51.99'' N, 114[deg]21'03.83'' W South Zone Line: 34[deg]27'07.99'' N, 114[deg...

STS-114 and Expedition 11 Onboard Group Photo

NASA Technical Reports Server (NTRS)

2005-01-01

The seven crew members of the STS-114 mission and two Expedition 11 crew members gather for a group shot in the Destiny Laboratory of the International Space Station (ISS). From the left (front row) are astronauts Andrew S. W. Thomas, mission specialist (MS); Eileen M. Collins, STS-114 commander; Cosmonaut Sergei K. Kriklev, Expedition 11 commander representing Russia's Federal Space Agency; and John L. Phillips, Expedition 11 NASA Space Station officer and flight engineer. From the left (back row) are astronauts Soichi Noguchi, STS-114 MS, representing the Japan Aerospace Exploration Agency (JAXA); James M. Kelly, STS-114 pilot; and Charles J. Camarda, Wendy B. Lawrence, and Stephen K. Robinson, all STS-114 mission specialists.

48 CFR 18.114 - Contracting with the Small Business Administration (The 8(a) Program).

Code of Federal Regulations, 2011 CFR

2011-10-01

... Business Administration (The 8(a) Program). 18.114 Section 18.114 Federal Acquisition Regulations System... Acquisition Flexibilities 18.114 Contracting with the Small Business Administration (The 8(a) Program). Contracts may be awarded to the Small Business Administration (SBA) for performance by eligible 8(a) firms...

48 CFR 18.114 - Contracting with the Small Business Administration (The 8(a) Program).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Business Administration (The 8(a) Program). 18.114 Section 18.114 Federal Acquisition Regulations System... Acquisition Flexibilities 18.114 Contracting with the Small Business Administration (The 8(a) Program). Contracts may be awarded to the Small Business Administration (SBA) for performance by eligible 8(a) firms...

14 CFR 1215.114 - Service rates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... (TDRSS) Use and Reimbursement Policy for Non-U.S. Government Users § 1215.114 Service rates. (a) Non-U.S... user. These rates are subject to change. (e) The per minute charge for TDRSS service is computed by... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Service rates. 1215.114 Section 1215.114...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

7 CFR 1.14 - Appeals.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Appeals. 1.14 Section 1.14 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.14 Appeals. (a) Requesters seeking administrative appeal of a denial of a request for records or denial of a fee waiver must ensure that the appeal...

21 CFR 163.114 - Lowfat cocoa.

Code of Federal Regulations, 2010 CFR

2010-04-01

... CONSUMPTION CACAO PRODUCTS Requirements for Specific Standardized Cacao Products § 163.114 Lowfat cocoa. (a) Description. Lowfat cocoa is the food that conforms to the definition and standard of identity, and is subject... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Lowfat cocoa. 163.114 Section 163.114 Food and...

29 CFR 452.114 - Write-in votes.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Write-in votes. 452.114 Section 452.114 Labor Regulations... OF 1959 Election Procedures; Rights of Members § 452.114 Write-in votes. Where write-in votes are... an election complaint under section 402 and then only if the arrangements for write-in votes were so...

19 CFR 122.114 - Contents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Contents. 122.114 Section 122.114 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit air cargo...

29 CFR 1915.114 - Chain falls and pull-lifts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 7 2010-07-01 2010-07-01 false Chain falls and pull-lifts. 1915.114 Section 1915.114 Labor... and Materials Handling § 1915.114 Chain falls and pull-lifts. The provisions of this section shall apply to ship repairing, shipbuilding and shipbreaking. (a) Chain falls and pull-lifts shall be clearly...

29 CFR 1915.114 - Chain falls and pull-lifts.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 7 2011-07-01 2011-07-01 false Chain falls and pull-lifts. 1915.114 Section 1915.114 Labor... and Materials Handling § 1915.114 Chain falls and pull-lifts. The provisions of this section shall apply to ship repairing, shipbuilding and shipbreaking. (a) Chain falls and pull-lifts shall be clearly...

14 CFR 1215.114 - Service rates.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Service rates. 1215.114 Section 1215.114... (TDRSS) Use and Reimbursement Policy for Non-U.S. Government Users § 1215.114 Service rates. (a) Rates for TDRSS services will be established by the DAA for SCaN. (b) Per-minute rates will reflect TDRSS...

14 CFR 1215.114 - Service rates.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Service rates. 1215.114 Section 1215.114... (TDRSS) Use and Reimbursement Policy for Non-U.S. Government Users § 1215.114 Service rates. (a) Non-U.S. Government user rates will reflect TDRSS total operational and maintenance costs prorated to a per-minute...

29 CFR 1915.114 - Chain falls and pull-lifts.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 7 2014-07-01 2014-07-01 false Chain falls and pull-lifts. 1915.114 Section 1915.114 Labor... and Materials Handling § 1915.114 Chain falls and pull-lifts. The provisions of this section shall apply to ship repairing, shipbuilding and shipbreaking. (a) Chain falls and pull-lifts shall be clearly...

29 CFR 1915.114 - Chain falls and pull-lifts.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 7 2013-07-01 2013-07-01 false Chain falls and pull-lifts. 1915.114 Section 1915.114 Labor... and Materials Handling § 1915.114 Chain falls and pull-lifts. The provisions of this section shall apply to ship repairing, shipbuilding and shipbreaking. (a) Chain falls and pull-lifts shall be clearly...

29 CFR 1915.114 - Chain falls and pull-lifts.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 7 2012-07-01 2012-07-01 false Chain falls and pull-lifts. 1915.114 Section 1915.114 Labor... and Materials Handling § 1915.114 Chain falls and pull-lifts. The provisions of this section shall apply to ship repairing, shipbuilding and shipbreaking. (a) Chain falls and pull-lifts shall be clearly...

19 CFR 114.23 - Maximum period.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Maximum period. 114.23 Section 114.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARNETS Processing of Carnets § 114.23 Maximum period. (a) A.T.A. carnet. No A.T.A. carnet with a period...

9 CFR 11.4 - Inspection and detention of horses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Inspection and detention of horses. 11.4 Section 11.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.4 Inspection and detention of horses. For the...

9 CFR 11.4 - Inspection and detention of horses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Inspection and detention of horses. 11.4 Section 11.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.4 Inspection and detention of horses. For the...

9 CFR 11.4 - Inspection and detention of horses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Inspection and detention of horses. 11.4 Section 11.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.4 Inspection and detention of horses. For the...

9 CFR 11.4 - Inspection and detention of horses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Inspection and detention of horses. 11.4 Section 11.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.4 Inspection and detention of horses. For the...

9 CFR 11.4 - Inspection and detention of horses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Inspection and detention of horses. 11.4 Section 11.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.4 Inspection and detention of horses. For the...

49 CFR 230.114 - Wheel centers.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., following the repair, the crankpin and axle shall remain tight in the wheel. Banding of the hub is permitted... 49 Transportation 4 2013-10-01 2013-10-01 false Wheel centers. 230.114 Section 230.114... Tenders Wheels and Tires § 230.114 Wheel centers. (a) Filling blocks and shims. Driving and trailing wheel...

49 CFR 230.114 - Wheel centers.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., following the repair, the crankpin and axle shall remain tight in the wheel. Banding of the hub is permitted... 49 Transportation 4 2014-10-01 2014-10-01 false Wheel centers. 230.114 Section 230.114... Tenders Wheels and Tires § 230.114 Wheel centers. (a) Filling blocks and shims. Driving and trailing wheel...

49 CFR 230.114 - Wheel centers.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., following the repair, the crankpin and axle shall remain tight in the wheel. Banding of the hub is permitted... 49 Transportation 4 2012-10-01 2012-10-01 false Wheel centers. 230.114 Section 230.114... Tenders Wheels and Tires § 230.114 Wheel centers. (a) Filling blocks and shims. Driving and trailing wheel...

49 CFR 230.114 - Wheel centers.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., following the repair, the crankpin and axle shall remain tight in the wheel. Banding of the hub is permitted... 49 Transportation 4 2011-10-01 2011-10-01 false Wheel centers. 230.114 Section 230.114... Tenders Wheels and Tires § 230.114 Wheel centers. (a) Filling blocks and shims. Driving and trailing wheel...

49 CFR 230.114 - Wheel centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., following the repair, the crankpin and axle shall remain tight in the wheel. Banding of the hub is permitted... 49 Transportation 4 2010-10-01 2010-10-01 false Wheel centers. 230.114 Section 230.114... Tenders Wheels and Tires § 230.114 Wheel centers. (a) Filling blocks and shims. Driving and trailing wheel...

38 CFR 75.114 - Accelerated response.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Accelerated response. 75.114 Section 75.114 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) INFORMATION SECURITY MATTERS Data Breaches § 75.114 Accelerated response. (a) The Secretary, in the exercise of his or her discretion, may provide...

Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

PubMed Central

Carballo, Jesús A.; Panizza, Silvia; Serrentino, Maria Elisabetta; Johnson, Anthony L.; Geymonat, Marco; Borde, Valérie; Klein, Franz; Cha, Rita S.

2013-01-01

An essential feature of meiosis is Spo11 catalysis of programmed DNA double strand breaks (DSBs). Evidence suggests that the number of DSBs generated per meiosis is genetically determined and that this ability to maintain a pre-determined DSB level, or “DSB homeostasis”, might be a property of the meiotic program. Here, we present direct evidence that Rec114, an evolutionarily conserved essential component of the meiotic DSB-machinery, interacts with DSB hotspot DNA, and that Tel1 and Mec1, the budding yeast ATM and ATR, respectively, down-regulate Rec114 upon meiotic DSB formation through phosphorylation. Mimicking constitutive phosphorylation reduces the interaction between Rec114 and DSB hotspot DNA, resulting in a reduction and/or delay in DSB formation. Conversely, a non-phosphorylatable rec114 allele confers a genome-wide increase in both DSB levels and in the interaction between Rec114 and the DSB hotspot DNA. These observations strongly suggest that Tel1 and/or Mec1 phosphorylation of Rec114 following Spo11 catalysis down-regulates DSB formation by limiting the interaction between Rec114 and DSB hotspots. We also present evidence that Ndt80, a meiosis specific transcription factor, contributes to Rec114 degradation, consistent with its requirement for complete cessation of DSB formation. Loss of Rec114 foci from chromatin is associated with homolog synapsis but independent of Ndt80 or Tel1/Mec1 phosphorylation. Taken together, we present evidence for three independent ways of regulating Rec114 activity, which likely contribute to meiotic DSBs-homeostasis in maintaining genetically determined levels of breaks. PMID:23825959

Molecular genetic characterization of the RD-114 gene family of endogenous feline retroviral sequences.

PubMed Central

Reeves, R H; O'Brien, S J

1984-01-01

RD-114 is a replication-competent, xenotropic retrovirus which is homologous to a family of moderately repetitive DNA sequences present at ca. 20 copies in the normal cellular genome of domestic cats. To examine the extent and character of genomic divergence of the RD-114 gene family as well as to assess their positional association within the cat genome, we have prepared a series of molecular clones of endogenous RD-114 DNA segments from a genomic library of cat cellular DNA. Their restriction endonuclease maps were compared with each other as well as to that of the prototype-inducible RD-114 which was molecularly cloned from a chronically infected human cell line. The endogenous sequences analyzed were similar to each other in that they were colinear with RD-114 proviral DNA, were bounded by long terminal redundancies, and conserved many restriction sites in the gag and pol regions. However, the env regions of many of the sequences examined were substantially deleted. Several of the endogenous RD-114 genomes contained a novel envelope sequence which was unrelated to the env gene of the prototype RD-114 env gene but which, like RD-114 and endogenous feline leukemia virus provirus, was found only in species of the genus Felis, and not in other closely related Felidae genera. The endogenous RD-114 sequences each had a distinct cellular flank which indicates that these sequences are not tandem but dispersed nonspecifically throughout the genome. Southern analysis of cat cellular DNA confirmed the conclusions about conserved restriction sites in endogenous sequences and indicated that a single locus may be responsible for the production of the major inducible form of RD-114. Images PMID:6090693

Forest carbon stocks and fluxes in physiographic zones of India.

PubMed

Sheikh, Mehraj A; Kumar, Munesh; Bussman, Rainer W; Todaria, Np

2011-12-25

Reducing carbon Emissions from Deforestation and Degradation (REDD+) is of central importance to combat climate change. Foremost among the challenges is quantifying nation's carbon emissions from deforestation and degradation, which requires information on forest carbon storage. Here we estimated carbon storage in India's forest biomass for the years 2003, 2005 and 2007 and the net flux caused by deforestation and degradation, between two assessment periods i.e., Assessment Period first (ASP I), 2003-2005 and Assessment Period second (ASP II), 2005-2007. The total estimated carbon stock in India's forest biomass varied from 3325 to 3161 Mt during the years 2003 to 2007 respectively. There was a net flux of 372 Mt of CO2 in ASP I and 288 Mt of CO2 in ASP II, with an annual emission of 186 and 114 Mt of CO2 respectively. The carbon stock in India's forest biomass decreased continuously from 2003 onwards, despite slight increase in forest cover. The rate of carbon loss from the forest biomass in ASP II has dropped by 38.27% compared to ASP I. With the Copenhagen Accord, India along with other BASIC countries China, Brazil and South Africa is voluntarily going to cut emissions. India will voluntary reduce the emission intensity of its GDP by 20-25% by 2020 in comparison to 2005 level, activities like REDD+ can provide a relatively cost-effective way of offsetting emissions, either by increasing the removals of greenhouse gases from the atmosphere by afforestation programmes, managing forests, or by reducing emissions through deforestation and degradation.

Distance Learning Course for Healthcare Professionals: Continuing Education in Tuberculosis.

PubMed

Cabral, Vagner Kunz; Valentini, Dirceu Felipe; Rocha, Marcos Vinícius Vieira; de Almeida, Carlos Podalírio Borges; Cazella, Sílvio Cesar; Silva, Denise Rossato

2017-12-01

Continuing education of healthcare workers (HCWs) is an essential strategy for the control of tuberculosis (TB) transmission, enabling HCWs in early detection and appropriate treatment of TB cases. We developed a distance learning (DL) course on TB for nurses. We conducted a quasi-experimental before and after study to evaluate the DL community at the participant's learning level. In addition, to evaluate the DL community at the level of participant satisfaction, a cross-sectional study was carried out after the course. Nurses involved in active inpatient or outpatient care of patients were recruited to participate in the study. Sixty-six participants started and completed the course and they were included in the analysis. The overall mean pretest and post-test scores were 10.3 ± 2.2 and 11.4 ± 2.7, respectively. Participants increased their knowledge to a statistically significant degree (p < 0.0001). At baseline, the frequency of correct answers was very low in some questions: number of people infected by Mycobacterium tuberculosis in the world (10.6%); number of TB cases in Brazil (36.4%); contagiousness of latent TB infection (LTBI) (28.8%); and definition of active case finding (45.5%). Course feedback was mostly positive, with majority of users saying they were satisfied or totally satisfied. A brief DL course on TB was associated with some improvement in knowledge among nurses. The baseline knowledge was low regarding TB epidemiologic data, concepts on LTBI, and active case finding. This finding emphasizes the need to further improve the competencies and knowledge of nurses.

Whole Grain Intake and Glycaemic Control in Healthy Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

PubMed

Marventano, Stefano; Vetrani, Claudia; Vitale, Marilena; Godos, Justyna; Riccardi, Gabriele; Grosso, Giuseppe

2017-07-19

There is growing evidence from both observational and intervention studies that Whole Grain (WG) cereals exert beneficial effects on human health, especially on the metabolic profile. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCT) to assess the acute and medium/long-term effect of WG foods on glycaemic control and insulin sensitivity in healthy individuals. A search for all the published RCT on the effect of WG food intake on glycaemic and insulin response was performed up to December 2016. Effect size consisted of mean difference (MD) and 95% CI between the outcomes of intervention and the control groups using the generic inverse-variance random effects model. The meta-analysis of the 14 studies testing the acute effects of WG foods showed significant reductions of the post-prandial values of the glucose iAUC (0-120 min) by -29.71 mmol min/L (95% CI: -43.57, -15.85 mmol min/L), the insulin iAUC (0-120 min) by -2.01 nmol min/L (95% CI: -2.88, -1.14 nmol min/L), and the maximal glucose and insulin response. In 16 medium- and long-term RCTs, effects of WG foods on fasting glucose and insulin and homeostatic model assessment-insulin resistance values were not significant. The consumption of WG foods is able to improve acutely the postprandial glucose and insulin homeostasis compared to similar refined foods in healthy subjects. Further research is needed to better understand the long-term effects and the biological mechanisms.

THE IMPACT OF MODE OF ACQUISITION ON BIOLOGICAL MARKERS OF PAEDIATRIC HEPATITIS C VIRUS INFECTION

PubMed Central

England, Kirsty; Thorne, Claire; Harris, Helen; Ramsay, Mary; Newell, Marie-Louise

2012-01-01

Background Despite the introduction of blood donor screening, worldwide, children continue to become infected with HCV via un-sterile medical injections, receipt of unscreened blood and isolated hospital contamination outbreaks. It is plausible that the natural history and disease progression in these children might differ from that of their vertically infected counterparts. Materials and Methods Vertically and parenterally HCV infected children were prospectively followed within the European Paediatric HCV Network and the UK National HCV Register respectively. Biological profiles were compared. Results Vertically and parenterally HCV infected children differed in terms of some key characteristics including the male:female ratio and the proportion of children receiving therapy. Parenterally infected children were more likely to have at least one hepatomegaly event during follow-up, 20% vs. 10%. Parenteral infection did not significantly affect the odds of being consistently viraemic, AOR 1.14 p=0.703 and there was no significant difference in the odds of having consistently elevated ALT levels and mode of acquisition, AOR 0.83 p=0.748. The proportion of children with 2 or more markers of HCV infection did not differ significantly by mode of acquisition, χ21.13 p=0.288. Conclusions This analysis does not support substantial differences between vertically and parenterally infected groups but there are specific mechanisms identified requiring further investigation. Given the continued parenteral infection of children worldwide it is vital that knowledge of disease progression in this group is accurate and that the differences in comparison to vertically infected children are clarified to inform more accurate and individualised clinical management. PMID:21762285

Critical incidents in a French department of paediatric anaesthesia.

PubMed

Kupersztych-Hagege, Elisa; Duracher-Gout, Caroline; Ortego, Rocio; Carli, Pierre; Orliaguet, Gilles

2017-04-01

Several studies have highlighted the importance of critical incident (CI) reporting in order to enhance patient safety. We have implemented an anonymous procedure for CI reporting in our department of paediatric anaesthesia. This study aims at analysing those CIs so as to improve patient care and risk management. CIs were reported by the anaesthetic team using the World Health Organization classification and analysed using the ORION methodology. CIs were classified according to type, surgery and complications. Risk factors and consequences for patients and for the institution were analysed. Risk factors with high degree of harm for the patient were identified using a univariate analysis and odds ratios (OR). Over an 18-month period, 114 CIs were reported for 103 patients (median age: 7.0 years [95% CI: 3.6-9.8]). We found that 29.9% of reported CIs had consequences for the patients and 76.3% were considered preventable. The two main types of CI were "respiratory" (28.8%) and "drug-related" (22.8%) incidents. The main risk factor was 'human error' (42.3%). Several consequences for the patient and the hospital were identified. An ASA score≥3 (OR: 2.52; [95% CI: 1.10-5.78]) was an independent risk factor for a high degree of patient harm. Improving quality of care must be a priority for paediatric anaesthesiologists as most of the CIs observed are preventable and have consequences for the patient and the institution. Copyright © 2016 Société française d'anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.

Forest carbon stocks and fluxes in physiographic zones of India

PubMed Central

2011-01-01

Background Reducing carbon Emissions from Deforestation and Degradation (REDD+) is of central importance to combat climate change. Foremost among the challenges is quantifying nation's carbon emissions from deforestation and degradation, which requires information on forest carbon storage. Here we estimated carbon storage in India's forest biomass for the years 2003, 2005 and 2007 and the net flux caused by deforestation and degradation, between two assessment periods i.e., Assessment Period first (ASP I), 2003-2005 and Assessment Period second (ASP II), 2005-2007. Results The total estimated carbon stock in India's forest biomass varied from 3325 to 3161 Mt during the years 2003 to 2007 respectively. There was a net flux of 372 Mt of CO2 in ASP I and 288 Mt of CO2 in ASP II, with an annual emission of 186 and 114 Mt of CO2 respectively. The carbon stock in India's forest biomass decreased continuously from 2003 onwards, despite slight increase in forest cover. The rate of carbon loss from the forest biomass in ASP II has dropped by 38.27% compared to ASP I. Conclusion With the Copenhagen Accord, India along with other BASIC countries China, Brazil and South Africa is voluntarily going to cut emissions. India will voluntary reduce the emission intensity of its GDP by 20-25% by 2020 in comparison to 2005 level, activities like REDD+ can provide a relatively cost-effective way of offsetting emissions, either by increasing the removals of greenhouse gases from the atmosphere by afforestation programmes, managing forests, or by reducing emissions through deforestation and degradation. PMID:22196920

Childhood ADHD and addictive behaviours in adolescence: a canadian sample.

PubMed

Ostojic, Dragana; Charach, Alice; Henderson, Joanna; McAuley, Tara; Crosbie, Jennifer

2014-05-01

To compare rates of early addictive behaviours in a clinic sample of youth with childhood attention-deficit/hyperactivity disorder (ADHD) with those in community populations. We surveyed 142 adolescents (14.1 ± 1.14 years), diagnosed with ADHD before age 12, about early substance use and problem gambling using questions from two cross-sectional population studies: the Canadian National Longitudinal Survey of Children and Youth, Ontario subsample, (N=1,317; 10-15 years) and the Ontario Student Drug Use and Health Survey (N=9,288; 12-18 years). The ADHD sample reported using cigarettes, 17.8% (95% CI 12.1-25.5), alcohol, 27.1% (20.1-35.5), cannabis, 14.2% (8.9-21.7), at a similar or lower rate than the NLSCY (cigarettes, 28.3% (25.8-30.9), alcohol, 28.6% (26.0-31.3), cannabis, 16.5% (14.0-19.4), and OSDUHS samples (cigarettes, 21.9% (20.2-23.7), alcohol, 58.6% (56.0-61.2), cannabis, 26.0% (23.9-28.2). With regards to gambling, there is a non-significant trend for ADHD youth to report gambling more frequently than the provincial average, 7.9% (3.3-17.9) vs. 4.3% (2.9-6.3). Our findings support the emerging literature that youth diagnosed with ADHD in childhood may not be at greater risk for onset of substance use in early adolescence. The study identified two areas that warrant further investigation in this population; the possible increased risk for substance use among females and a trend toward early onset of gambling behaviours.

2,4-Dichlorophenoxyacetic acid and non-Hodgkin's lymphoma, gastric cancer, and prostate cancer: meta-analyses of the published literature.

PubMed

Goodman, Julie E; Loftus, Christine T; Zu, Ke

2015-08-01

Despite evidence from experimental studies indicating that the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), is not carcinogenic, several epidemiology studies have evaluated links between 2,4-D and cancer. Some suggest that 2,4-D is associated with non-Hodgkin's lymphoma (NHL), gastric cancer, and prostate cancer, but results have been inconsistent. We conducted meta-analyses to evaluate the weight of epidemiology evidence for these cancers. We identified articles from PubMed, Scopus, and TOXLINE databases and reference lists of review articles. We evaluated study quality and calculated summary risk estimates using random effects models. We conducted subgroup and sensitivity analyses when possible. We identified nine NHL, three gastric cancer, and two prostate cancer studies for inclusion in our meta-analyses. We found that 2,4-D was not associated with NHL (relative risk [RR] = 0.97, 95% confidence interval [CI] = 0.77-1.22, I(2) = 28.8%, Pheterogeneity = .19), and this result was generally robust to subgroup and sensitivity analyses. 2,4-D was not associated with gastric (RR = 1.14, 95% CI = 0.62-2.10, I(2) = 54.9%, Pheterogeneity = .11) or prostate cancer (RR = 1.32, 95% CI = 0.37-4.69, I(2) 87.0%, Pheterogeneity = .01). The epidemiology evidence does not support an association between 2,4-D and NHL, gastric cancer, or prostate cancer risk. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Effect of acaricidal components isolated from lettuce (Lactuca sativa) on carmine spider mite (Tetranychus cinnabarinus Boisd.).

PubMed

Li, M; Zhang, Y; Ding, W; Luo, J; Li, S; Zhang, Q

2018-06-01

This study aimed to evaluate the acaricidal activity of lettuce (Lactuca sativa) extracts against carmine spider mites (Tetranychus cinnabarinus Boisd.) and isolate the acaricidal components. Acaricidal activities of lettuce extracts isolated from different parts (the leaf, root and seed) using various solvents (petroleum ether, acetone and methanol) were evaluated with slide-dip bioassay and relatively high median lethal concentration (LC50) values were detected. Acetone extracts of lettuce leaves harvested in July and September were fractionated and isolated with silica gel and thin-layer chromatography. Consequently, acetone extracts of lettuce leaves harvested in July exhibited higher acaricidal activity than those harvested in September, with an LC50 value of 0.268 mg ml-1 at 72 h post-treatment. A total of 27 fractions were obtained from the acetone extract of lettuce leaves harvested in July, and mite mortalities with the 11th and 12th fractions were higher than those with the other 25 fractions (LC50: 0.751 and 1.258 mg ml-1 at 48 h post-treatment, respectively). Subsequently, active acaricidal components of the 11th fraction were identified by infrared, nuclear magnetic resonance and liquid chromatography/mass spectrometry. Five components were isolated from the 11th fraction, with components 11-a and 11-b showing relatively high acaricidal activities (LC50: 0.288 and 0.114 mg ml-1 at 48 h post-treatment, respectively). Component 11-a was identified as β-sitosterol. In conclusion, acetone extracts of lettuce leaves harvested in July might be used as a novel phytogenic acaricide to control mites.

Contraception and pregnancy then and now: examining the experiences of a cohort of mid-age Australian women.

PubMed

Read, Christine; Bateson, Deborah; Weisberg, Edith; Estoesta, Jane

2009-08-01

More than 50% of women who have an unplanned pregnancy report using a contraceptive method. Since the launch of the pill 50 years ago, a number of cross-sectional surveys have examined contraceptive use in the Australian context. There is, however, little data on contraceptive use and efficacy over a woman's reproductive years. To determine the pattern of contraceptive use of Australian women over their reproductive lifespan, with particular emphasis on the relationship between contraceptive use and pregnancy. One thousand women from the mid-age cohort of the Australian Women's Longitudinal Study were invited to participate in the Family Planning survey by completing a questionnaire about their reproductive histories. Completed questionnaires were received for 812 women. The contraceptive pill was the most commonly ever used contraceptive method at 94% and also the most commonly used method prior to all pregnancies. Contraceptive failure increased with increasing gravidity; 11.4% with the first pregnancy to 23.0% with the fourth pregnancy, while 28.8% of the respondents reported an 'accidental' pregnancy due to stopping contraception for reasons such as concern about long-term effects and media stories. While surveys indicate that 66-70% of Australian women use a contraceptive method, more than half of unplanned pregnancies apparently occur in women using contraception. The modern Australian woman, in common with her predecessors, still faces significant challenges in her fertility management. This survey provides a longitudinal perspective on contraceptive use in relation to pregnancy and highlights the issue of efficacy of contraceptives in real-life situations.

[Dual contraception adherence among HIV-infected women].

PubMed

Brandão, Karina de Sá Adami Gonçalves; Lima, Bruno Gil de Carvalho; Travassos, Ana Gabriela Álvares; de Brito, Fabielle de Oliveira Rocha; de Souza, Eveline Xavier Pereira; Haguihara, Tatiana; da Silva, Carlos Alberto Lima

2015-10-01

To determine adherence to dual contraception using depot-medroxyprogesterone acetate (DMPA) and condom among HIV-infected women. A cross-sectional study carried out from December 2013 to September 2014 at a local reference center, with application of questionnaire elaborated after Delphi panel and content validation to 114 HIV(+) women aged 15 to 49 years, using DMPA plus condom for contraception. Mean age was 33.2 ± 7.2 years, mean time since HIV detection was 8.1 ± 5.2 years, mean time of antiretroviral use was 6.8 ± 5 years and mean CD4 cells/mm3 count was 737.6 ± 341.1. Sexual HIV acquisition was reported by 98.2% (112/114), antiretroviral use by 85.9% (98/114), and 77.7% (84/114) had a CD4>500/mm3 count. Having a single sex partner was reported by 78.9% (90/114), with HIV serodiscordance in 41.2% (47/114) of couples, 21.9% did not know the serological status of their partner and in 37.7% of cases (43/114) the partner was unaware of the HIV(+) status of the woman. The last pregnancy was unplanned in 71.9% of cases (82/114) and 14.9% of the women had become pregnant the year before, with pregnancy being unplanned in 70.5% (12/17) of cases. Current use of DMPA was reported by 64.9% (74/114), with genital bleeding in 48.2% (55/114) and weight gain in 67.5% (77/114). Use of a male condom was reported by 62.2% of the subjects (71/114). Three reported that they always used a female condom and ten that they eventually used it. Unprotected vaginal sex was reported by 37.7% (43/114) and unprotected anal intercourse was reported by 32.4% (37/114). Partner resistance to use a condom occurred in 30.7% of cases (35/114). Dual contraception using DMPA with condom was reported by 42.9% (49/114). A partner who resisted wearing a condom was associated with poor adhesion (PR=0.3; 95%CI 0.2-0.7; p<0.001). A partner who was unaware that a woman was infected with HIV favored adherence (PR=1.8; 95%CI 1.2-2.7; p=0.013). The percentage of dual contraception using DMPA plus condom was 42.9%, maintaining unplanned pregnancies and unprotected sex. Resistance of partners to use a condom increased three times the chance of a woman not adhering to dual contraception, and the partner not knowing women's HIV infection almost doubled the chance to adhere to safe contraception. to offer new hormonal contraceptives and to involve the partners in contraception and serologic detection tests.

Millimeter-wave studies

NASA Technical Reports Server (NTRS)

Allen, Kenneth C.

1988-01-01

Progress on millimeter-wave propagation experiments in Hawaii is reported. A short path for measuring attenuation in rain at 9.6, 28.8, 57.6, and 96.1 GHz is in operation. A slant path from Hilo to the top of Mauna Kea is scheduled. On this path, scattering from rain and clouds that may cause interference for satellites closely spaced in geosynchronous orbit will be measured at the same frequencies at 28.8 and 96.1 GHz. In addition the full transmission matrix will be measured at the same frequencies on the slant path. The technique and equipment used to measure the transmission matrix are described.

Occupational Survey Report. Food Service Career Ladder AFSC 622X0

DTIC Science & Technology

1980-09-01

FRY MEATS, SEAFOODS, OR POULTRY 47 G212 COOK CEREALS SUCH AS OATMEAL OR CORNMEAL 47 G209 BRAISE MEATS, SEAFOODS, OR POULTRY 47 G253 PREPARE MEATS...OATMEAL OR CORNMEAL 62 G210 BREW COFFEE OR TEA 62 G259 PREPARE SANDWICHES 61 G245 PREPARE GARNISHES 61 G260 PREPARE SOUPS 61 1341 CLEAN WORK TABLES 61 H288...EGGS FOR COOKING 80 G260 PREPARE SOUPS 80 G257 PREPARE RICE OR PASTA 80 G212 COOK CEREALS, SUCH AS OATMEAL OR CORNMEAL 77 H288 PREPARE GRIDDLES FOR USE

49 CFR 179.103 - Special requirements for class 114A * * * tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Special requirements for class 114A * * * tank car...) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.103 Special requirements for class 114A * * * tank car tanks. (a) In addition to the applicable...

49 CFR 179.103 - Special requirements for class 114A * * * tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Special requirements for class 114A * * * tank car...) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.103 Special requirements for class 114A * * * tank car tanks. (a) In addition to the applicable...

49 CFR 179.103 - Special requirements for class 114A * * * tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Special requirements for class 114A * * * tank car...) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.103 Special requirements for class 114A * * * tank car tanks. (a) In addition to the applicable...

49 CFR 179.103 - Special requirements for class 114A * * * tank car tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Special requirements for class 114A * * * tank car... SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.103 Special requirements for class 114A * * * tank car tanks. (a) In addition to the applicable...

19 CFR § 122.114 - Contents.

Code of Federal Regulations, 2010 CFR

2008-04-01

... 19 Customs Duties 1 2008-04-01 2008-04-01 false Contents. § 122.114 Section § 122.114 Customs Duties BUREAU OF CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.114 Contents. (a) Form duplicates original manifest. Each transit...

30 CFR 291.114 - How do I appeal to the IBLA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I appeal to the IBLA? 291.114 Section 291.114 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR APPEALS OPEN AND NONDISCRIMINATORY ACCESS TO OIL AND GAS PIPELINES UNDER THE OUTER CONTINENTAL SHELF LANDS ACT § 291.114 How do I...

Time-Based Competition for Competitive Advantage: An Information Technology Perspective

DTIC Science & Technology

1990-05-25

Northern Telecom Competes on Time," Harvard Business Review (July-August 1989): 109. 5 Stalk, Jr., 48. 6 Stalk, 49. 7 Dumaine, 56. 8 Beverly Geber , "Speed...Where the People Fit In," Training, 24 August 1989: 27. 9 Dumaine, 56. 10 Bower, 114. 11 Bower, 114. 12 Dumaine, 57. 13 Bower, 115. 14 Geber , 29. 15... Geber , 28. 70 16 Geber , 29. 17 Dumaine, 59. 18 Geber , 29. 19 Merrills, 113. 20 Merrills, 114. 21 Merrills, 114. 22 Merrills, 114. 23 Merrills, 113. 24

Better Care Teams: A Stepwise Skill Reinforcement Model.

PubMed

Christopher, Beth-Anne; Grantner, Mary; Coke, Lola A; Wideman, Marilyn; Kwakwa, Francis

2016-06-01

The Building Healthy Urban Communities initiative presents a path for organizations partnering to improve patient outcomes with continuing education (CE) as a key component. Components of the CE initiative included traditional CE delivery formats with an essential element of adaptability and new methods, with rigorous evaluation over time that included evaluation prior to the course, immediately following the CE session, 6 to 8 weeks after the CE session, and then subsequent monthly "testlets." Outcome measures were designed to allow for ongoing adaptation of content, reinforcement of key learning objectives, and use of innovative concordant testing and retrieval practice techniques. The results after 1 year of programming suggest the stepwise skill reinforcement model is effective for learning and is an efficient use of financial and human resources. More important, its design is one that could be adopted at low cost by organizations willing to work in close partnership. J Contin Educ Nurs. 2016;47(6):283-288. Copyright 2016, SLACK Incorporated.

PlantTFDB 3.0: a portal for the functional and evolutionary study of plant transcription factors

PubMed Central

Jin, Jinpu; Zhang, He; Kong, Lei; Gao, Ge; Luo, Jingchu

2014-01-01

With the aim to provide a resource for functional and evolutionary study of plant transcription factors (TFs), we updated the plant TF database PlantTFDB to version 3.0 (http://planttfdb.cbi.pku.edu.cn). After refining the TF classification pipeline, we systematically identified 129 288 TFs from 83 species, of which 67 species have genome sequences, covering main lineages of green plants. Besides the abundant annotation provided in the previous version, we generated more annotations for identified TFs, including expression, regulation, interaction, conserved elements, phenotype information, expert-curated descriptions derived from UniProt, TAIR and NCBI GeneRIF, as well as references to provide clues for functional studies of TFs. To help identify evolutionary relationship among identified TFs, we assigned 69 450 TFs into 3924 orthologous groups, and constructed 9217 phylogenetic trees for TFs within the same families or same orthologous groups, respectively. In addition, we set up a TF prediction server in this version for users to identify TFs from their own sequences. PMID:24174544

A comparison of reflector antenna designs for wide-angle scanning

NASA Technical Reports Server (NTRS)

Zimmerman, M.; Lee, S. W.; Houshmand, B.; Rahmatsamii, Y.; Acosta, R. J.

1989-01-01

Conventional reflector antennas are typically designed for up to + or - 20 beamwidths scan. An attempt was made to stretch this scan range to some + or - 300 beamwidths. Six single and dual reflector antennas were compared. It is found that a symmetrical parabolic reflector with f/D = 2 and a single circular waveguide feed has the minimum scan loss (only 0.6 dB at Theta sub 0 = 8 deg, or a 114 beamwidths scan). The scan is achieved by tilting the parabolic reflector by an angle equal to the half-scan angle. The f/D may be shortened if a cluster 7 to 19 elements instead of one element is used for the feed. The cluster excitation is adjusted for each new beam scan direction to compensate for the imperfect field distribution over the reflector aperture. The antenna can be folded into a Cassegrain configuration except that, due to spillover and blockage considerations, the amount of folding achievable is small.

Process standardization and characterization of Rajata Sindura.

PubMed

Gokarn, Rohit A; Gokarn, Supriya R; Hiremath, Shobha G

2014-01-01

Rajata Sindura (RS) is a mercurial preparation, known for its properties like Rasayana (rejuvinating), Balya (strengthening), Vrushya (aphrodisiac), Medhya (increasing intellect) and can cure various diseases when used with appropriate adjuvant. It is prepared with Hingulottha Parada (purified mercury), Shuddha Gandhaka (purified sulfur) and Shuddha Rajata (purified silver) in a proportion of 1:1:4. Process standardization and characterization of RS are not reported until date. Pharmaceutical standardization and characterization of Rajata Sindura. Purified mercury and silver were triturated to form amalgam, followed by the addition of purified sulfur to prepare Kajjali and lavigated with Vatankura (leaf buds of Ficus benghalensis Linn.) swarasa (juice). This Kajjali was processed by Kupipakwa method. RS was prepared in 33 h with 20.25% yield. Scanning electron microscope coupled with energy dispersive spectroscopy analysis has shown Mercury 86.21%, sulfur 13.27% as major elements; iron, calcium, potassium, magnesium and silver were other detected minor elements. X-ray diffraction report revealed the chemical nature of RS as HgS compound, having cubic crystal structure.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Honglin; Peng, Xiaohui; Key Laboratory of Structural Biology, Chinese Academy of Sciences, Hefei, Anhui 230026

This study examined recombinant wild-type human phosphoribosylpyrophosphate synthetase 1 (wt-PRS1, EC 2.7.6.1) and the point mutant Asn114Ser PRS1 (N114S-Mutant) in cells of a patient with primary gout. Dynamic light-scattering and sedimentation velocity experiments indicated that the monomeric wt-PRS1 in solution was assembled into hexamers after adding the substrate ATP. However, this ATP-induced aggregation effect was not observed with N114S-Mutant, which has a 50% higher enzymatic activity than that of wt-PRS1. Synchrotron radiation circular dichroism spectroscopy revealed that the point mutation causes an increase of {alpha}-helix content and a decrease of turn content. Examination of the crystal structure of wt-PRS1 indicatedmore » that 12 hydrogen bonds formed by 6 pairs of N114 and D139 have an important role in stabilizing the hexamer. We suggest that the substitution of S114 for N114 in N114S-Mutant leads to the rupture of 12 hydrogen bonds and breakage of the PO{sub 4}{sup 3-} allosteric site where PO{sub 4}{sup 3-} functions as a fixer of the ATP-binding loop. Therefore, we consider that formation of the hexamer as the structural basis of the ADP allosteric inhibition is greatly weakened by the N114S mutation, and that alteration of the ATP-binding loop conformation is the key factor in the increased activity of N114S-Mutant. These two factors could be responsible for the high level of activity of N114S-Mutant in this patient.« less

Multiple invasions of an infectious retrovirus in cat genomes

PubMed Central

Shimode, Sayumi; Nakagawa, So; Miyazawa, Takayuki

2015-01-01

Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of host germ-line cells. While most ERVs are defective, some are active and express viral proteins. The RD-114 virus is a replication-competent feline ERV, and several feline cell lines produce infectious RD-114 viral particles. All domestic cats are considered to have an ERV locus encoding a replication-competent RD-114 virus in their genomes; however, the locus has not been identified. In this study, we investigated RD-114 virus-related proviral loci in genomes of domestic cats, and found that none were capable of producing infectious viruses. We also found that all domestic cats have an RD-114 virus-related sequence on chromosome C2, termed RDRS C2a, but populations of the other RDRSs are different depending on the regions where cats live or breed. Our results indicate that RDRS C2a, the oldest RD-114-related provirus, entered the host genome before an ancestor of domestic cats started diverging and the other new RDRSs might have integrated into migrating cats in Europe. We also show that infectious RD-114 virus can be resurrected by the recombination between two non-infectious RDRSs. From these data, we conclude that cats do not harbor infectious RD-114 viral loci in their genomes and RD-114-related viruses invaded cat genomes multiple times. PMID:25641657

27 CFR 478.114 - Importation by members of the U.S. Armed Forces.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the U.S. Armed Forces. 478.114 Section 478.114 Alcohol, Tobacco Products, and Firearms BUREAU OF... FIREARMS AND AMMUNITION Importation § 478.114 Importation by members of the U.S. Armed Forces. (a) The... to the place of residence of any military member of the U.S. Armed Forces who is on active duty...

27 CFR 478.114 - Importation by members of the U.S. Armed Forces.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the U.S. Armed Forces. 478.114 Section 478.114 Alcohol, Tobacco Products, and Firearms BUREAU OF... FIREARMS AND AMMUNITION Importation § 478.114 Importation by members of the U.S. Armed Forces. (a) The... to the place of residence of any military member of the U.S. Armed Forces who is on active duty...

25 CFR 11.114 - What is the criminal jurisdiction of the Court of Indian Offenses?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What is the criminal jurisdiction of the Court of Indian Offenses? 11.114 Section 11.114 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.114 What is the criminal...

25 CFR 11.114 - What is the criminal jurisdiction of the Court of Indian Offenses?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false What is the criminal jurisdiction of the Court of Indian Offenses? 11.114 Section 11.114 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.114 What is the criminal...

25 CFR 11.114 - What is the criminal jurisdiction of the Court of Indian Offenses?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What is the criminal jurisdiction of the Court of Indian Offenses? 11.114 Section 11.114 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.114 What is the criminal...

25 CFR 11.114 - What is the criminal jurisdiction of the Court of Indian Offenses?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true What is the criminal jurisdiction of the Court of Indian Offenses? 11.114 Section 11.114 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.114 What is the criminal...

Comparison of the Trace Elements and Active Components of Lonicera japonica flos and Lonicera flos Using ICP-MS and HPLC-PDA.

PubMed

Zhao, Yueran; Dou, Deqiang; Guo, Yueqiu; Qi, Yue; Li, Jun; Jia, Dong

2018-06-01

Thirteen trace elements and active constituents of 40 batches of Lonicera japonica flos and Lonicera flos were comparatively studied using inductively coupled plasma mass-spectrometry (ICP-MS) and high-performance liquid chromatography-photodiode array (HPLC-PDA). The trace elements were 24 Mg, 52 Cr, 55 Mn, 57 Fe, 60 Ni, 63 Cu, 66 Zn, 75 As, 82 Se, 98 Mo, 114 Cd, 202 Hg, and 208 Pb, and the active compounds were chlorogenic acid, 3,5-O-dicaffeoylquinc acid, 4,5-O-dicaffeoylquinc acid, luteolin-7-O-glucoside, and 4-O-caffeoylquinic acid. The data of 18 variables were statistically processed using principal component analysis (PCA) and discriminate analysis (DA) to classify L. japonica flos and L. flos. The validated method was developed to divide the 40 samples into two groups based on the PCA in terms of 18 variables. Furthermore, the species of Lonicera was better discriminated by using DA with 12 variables. These results suggest that the method and statistical analysis of the contents of trace elements and chemical components can classify the L. japonica flos and L. flos using 12 variables, such as 3,5-O-dicaffeoylquincacid, luteolin-7-O-glucoside, Cd, Mn, Hg, Pb, Ni, 4-O-caffeoyl-quinic acid, 4,5-O-dicaffeoylquinc acid, Fe, Mg, and Cr.

Air-Coupled Low Frequency Ultrasonic Transducers and Arrays with PMN-32%PT Piezoelectric Crystals

PubMed Central

Kazys, Rymantas J.; Sliteris, Reimondas; Sestoke, Justina

2017-01-01

Air-coupled ultrasonic techniques are being increasingly used for material characterization, non-destructive evaluation of composite materials using guided waves as well as for distance measurements. Application of those techniques is mainly limited by the big losses of ultrasonic signals due to attenuation and mismatch of the acoustic impedances of ultrasonic transducers and air. One of the ways to solve this problem is by application of novel more efficient piezoelectric materials like lead magnesium niobate-lead titanate (PMN-PT) type crystals. The objective of this research was the development and investigation of low frequency (<50 kHz) wide band air-coupled ultrasonic transducers and arrays with an improved performance using PMN-32%PT crystals. Results of finite element modelling and experimental investigations of the developed transducers and arrays are presented. For improvement of the performance strip-like matching elements made of low acoustic impedance, materials such as polystyrene foams were applied. It allowed to achieve transduction losses for one single element transducer −11.4 dB, what is better than of commercially available air-coupled ultrasonic transducers. Theoretical and experimental investigations of the acoustic fields radiated by the eight element ultrasonic array demonstrated not only a good performance of the array in a pulse mode, but also very good possibilities to electronically focus and steer the ultrasonic beam in space. PMID:28067807

Material flow analysis of NdFeB magnets for Denmark: a comprehensive waste flow sampling and analysis approach.

PubMed

Habib, Komal; Schibye, Peter Klausen; Vestbø, Andreas Peter; Dall, Ole; Wenzel, Henrik

2014-10-21

Neodymium-iron-boron (NdFeB) magnets have become highly desirable for modern hi-tech applications. These magnets, in general, contain two key rare earth elements (REEs), i.e., neodymium (Nd) and dysprosium (Dy), which are responsible for the very high strength of these magnets, allowing for considerable size and weight reduction in modern applications. This study aims to explore the current and future potential of a secondary supply of neodymium and dysprosium from recycling of NdFeB magnets. For this purpose, material flow analysis (MFA) has been carried out to perform the detailed mapping of stocks and flows of NdFeB magnets in Denmark. A novel element of this study is the value added to the traditionally practiced MFAs at national and/or global levels by complementing them with a comprehensive sampling and elemental analysis of NdFeB magnets, taken out from a sample of 157 different products representing 18 various product types. The results show that the current amount of neodymium and dysprosium in NdFeB magnets present in the Danish waste stream is only 3 and 0.2 Mg, respectively. However, this number is estimated to increase to 175 Mg of neodymium and 11.4 Mg of dysprosium by 2035. Nevertheless, efficient recovery of these elements from a very diverse electronic waste stream remains a logistic and economic challenge.

Efficient Extracellular Expression of Metalloprotease for Z-Aspartame Synthesis.

PubMed

Zhu, Fucheng; Liu, Feng; Wu, Bin; He, Bingfang

2016-12-28

Metalloprotease PT121 and its mutant Y114S (Tyr114 was substituted to Ser) are effective catalysts for the synthesis of Z-aspartame (Z-APM). This study presents the selection of a suitable signal peptide for improving expression and extracellular secretion of proteases PT121 and Y114S by Escherichia coli. Co-inducers containing IPTG and arabinose were used to promote protease production and cell growth. Under optimal conditions, the expression levels of PT121 and Y114S reached >500 mg/L, and the extracellular activity of PT121/Y114S accounted for 87/82% of the total activity of proteases. Surprisingly, purer protein was obtained in the supernatant, because arabinose reduced cell membrane permeability, avoiding cell lysis. Comparison of Z-APM synthesis and caseinolysis between proteases PT121 and Y114S showed that mutant Y114S presented remarkably higher activity of Z-APM synthesis and considerably lower activity of caseinolysis. The significant difference in substrate specificity renders these enzymes promising biocatalysts.

Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes.

PubMed Central

Moola, Z B; Scawen, M D; Atkinson, T; Nicholls, D J

1994-01-01

This study shows that the antigenicity of Erwinia chrysanthemi L-asparaginase can be reduced by site-directed mutagenesis. Ten B-cell epitopes of the enzyme were identified using synthetic hexapeptides and polyclonal antisera from rabbits and mice. The region 282GIVPPDEELP292 near the C-terminus was an immunodominant epitope. Binding of two hexapeptides (283IVPPDE288 and 287DEELPG292) to the antibodies was dependent on Pro285, and Pro286, since their replacement by almost any other amino acid resulted in reduced binding. The other residues were less important for binding the antibodies, as binding was relatively unaffected by amino acid substitutions. Three site-directed mutant enzymes, P285T (proline-285-->threonine etc.), P286Q and E288A, were expressed in Escherichia coli. The purified enzymes had subunit M(r) values of 35,000. The pI values of P285T, P286Q and the wild-type enzymes were 8.6, and that for the mutant E288A was 9.2. The kcat. and Km values for the mutants P286Q and E288A with L-asparagine and L-glutamine were comparable with those of the wild-type enzyme. The Km values for the mutant P285T with both substrates was similar to that of the wild-type enzyme, whereas the kcat. was reduced by 2-fold with L-asparagine and by 4-fold with L-glutamine. The change proline-->threonine reduced the antigenicity of the enzyme by 8-fold, as shown in sandwich e.l.i.s.a.s. using monoclonal antibodies raised against the wild-type enzyme. PMID:7945221

Particle size alterations of feedstuffs during in situ neutral detergent fiber incubation.

PubMed

Krämer, M; Nørgaard, P; Lund, P; Weisbjerg, M R

2013-07-01

Particle size alterations during neutral detergent fiber (NDF) determination and in situ rumen incubation were analyzed by dry sieving and image analysis to evaluate the in situ procedure for estimation of NDF degradation parameters and indigestible NDF concentration in terms of particle size. Early-cut and late-cut grass silages, corn silage, alfalfa silage, rapeseed meal, and dried distillers grains were examined. Treatments were (1) drying and grinding of forage samples and grinding of concentrates; (2) neutral detergent-soluble (NDS) extraction; (3) machine washing and NDS extraction; (4) 24-h rumen incubation, machine washing, and NDS extraction; and (5) 288-h rumen incubation, machine washing, and NDS extraction. Degradation profiles for potentially degradable NDF were determined and image analysis was used to estimate particle size profiles and thereby the risk for particle loss. Particle dimensions changed during NDF determination and in situ rumen incubation and variations depended on feedstuff and treatment. Corn silage and late-cut grass silage varied most in particle area among feedstuffs, with an increase of 139% between 0 and 24h and a decrease of 77% between 24 and 288 h for corn silage and a decrease of 74% for late-cut grass silage between 24- and 288-h in situ rumen incubation. Especially for late-cut grass silage residues after 288 h in situ rumen incubation, a high mass proportion in the critical zone for escape was found. Particle area decreased linearly with increasing incubation time. Particle loss during in situ rumen incubation cannot be excluded and is likely to vary among feedstuffs. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Functional characterization of the novel intronic nucleotide change c.288+9C>T within the BCKDHA gene: understanding a variant presentation of maple syrup urine disease.

PubMed

Fernández-Guerra, Paula; Navarrete, Rosa; Weisiger, Kara; Desviat, Lourdes R; Packman, Seymour; Ugarte, Magdalena; Rodríguez-Pombo, Pilar

2010-12-01

Mutations in any of the three different genes--BCKDHA, BCKDHB, and DBT--encoding for the E1α, E1β, and E2 catalytic components of the branched-chain α-ketoacid dehydrogenase complex can cause maple syrup urine disease (MSUD). Disease severity ranges from the classic to the mildest variant types and precise genotypes, mostly based on missense mutations, have been associated to the less severe presentations of the disease. Herein, we examine the consequences at the messenger RNA (mRNA) level of the novel intronic alteration c.288+9C>T found in heterozygous fashion in a BCKDHA variant MSUD patient who also carries the nucleotide change c.745G>A (p.Gly249Ser), previously described as a severe change. Direct analysis of the processed transcripts from the patient showed--in addition to a low but measurable level of normal mRNA product--an aberrantly spliced mRNA containing a 7-bp fragment of intron 2, which could be rescued when the patient's cells were treated with emetine. This aberrant transcript with a premature stop codon would be unstable, supporting the possible activation of nonsense-mediated mRNA decay pathway. Consistent with this finding, minigene splicing assays demonstrated that the point mutation c.288+9C>T is sufficient to create a cryptic splice site and cause the observed 7-bp insertion. Furthermore, our results strongly suggest that the c.288+9C>T allele in the patient generates both normal and aberrant transcripts that could sustain the variant presentation of the disease, highlighting the importance of correct genotyping to establish genotype-phenotype correlations and as basis for the development of therapeutic interventions.

JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet.

PubMed

Nakatsu, Daiki; Kano, Fumi; Taguchi, Yuki; Sugawara, Taichi; Nishizono, Takashi; Nishikawa, Kiyotaka; Oda, Yukako; Furuse, Mikio; Murata, Masayuki

2014-07-01

Tricellular tight junctions (tTJs) are specialized structural variants of tight junctions within tricellular contacts of an epithelial sheet and comprise several transmembrane proteins including lipolysis-stimulated lipoprotein receptor (angulin-1/LSR) and tricellulin. To elucidate the mechanism of its formation, we carried out stepwise screening of kinase inhibitors followed by RNAi screening to identify kinases that regulate intracellular localization of angulin-1/LSR to the tTJs using a fluorescence image-based screen. We found that the activity of JNK1 and JNK2, but not JNK3, was required for the exclusive localization of angulin-1/LSR at the tTJs. Based on a bioinformatics approach, we estimated the potential phosphorylation site of angulin-1/LSR by JNK1 to be serine 288 and experimentally confirmed that JNK1 directly phosphorylates angulin-1/LSR at this site. We found that JNK2 was also involved in the phosphorylation of angulin-1/LSR. Furthermore, GFP-tagged angulin-1/LSR(S288A), in which serine 288 was substituted by alanine, was observed to be dispersed to bicellular junctions, indicating that phosphorylation of Ser288 is crucial for the exclusive localization of angulin-1/LSR and tricellulin at tTJs. Our fluorescence image-based screening for kinases inhibitor or siRNAs combined with the phosphorylation site prediction could become a versatile and useful tool to elucidate the mechanisms underlying the maintenance of tTJs regulated by kinase networks. © 2014 The Authors Genes to Cells © 2014 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

KSC-05PD-0605

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. From inside the viewing room of the Launch Control Center, KSC employees watch Space Shuttle Discovery as it creeps along the crawlerway toward the horizon, and Launch Pad 39B at NASAs Kennedy Space Center. First motion of the Shuttle out of the Vehicle Assembly Building (VAB) was at 2:04 p.m. EDT. The Mobile Launcher Platform is moved by the Crawler-Transporter underneath. The Crawler is 20 feet high, 131 feet long and 114 feet wide. It moves on eight tracks, each containing 57 shoes, or cleats, weighing one ton each. Loaded with the Space Shuttle, the Crawler can move at a maximum speed of approximately 1 mile an hour. A leveling system in the Crawler keeps the Shuttle vertical while negotiating the 5 percent grade leading to the top of the launch pad. Launch of Discovery on its Return to Flight mission, STS-114, is targeted for May 15 with a launch window that extends to June 3. During its 12-day mission, Discoverys seven-person crew will test new hardware and techniques to improve Shuttle safety, as well as deliver supplies to the International Space Station. Discovery was moved on March 29 from the Orbiter Processing Facility to the VAB and attached to its propulsion elements, a redesigned ET and twin SRBs.

KSC-05PD-0606

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. As Space Shuttle Discovery creeps along the crawlerway toward the horizon, and Launch Pad 39B at NASAs Kennedy Space Center, media and workers in the foreground appear as ants. First motion of the Shuttle out of the Vehicle Assembly Building (VAB) was at 2:04 p.m. EDT. The Mobile Launcher Platform is moved by the Crawler-Transporter underneath. The Crawler is 20 feet high, 131 feet long and 114 feet wide. It moves on eight tracks, each containing 57 shoes, or cleats, weighing one ton each. Loaded with the Space Shuttle, the Crawler can move at a maximum speed of approximately 1 mile an hour. A leveling system in the Crawler keeps the Shuttle vertical while negotiating the 5 percent grade leading to the top of the launch pad. Launch of Discovery on its Return to Flight mission, STS- 114, is targeted for May 15 with a launch window that extends to June 3. During its 12-day mission, Discoverys seven-person crew will test new hardware and techniques to improve Shuttle safety, as well as deliver supplies to the International Space Station. Discovery was moved on March 29 from the Orbiter Processing Facility to the VAB and attached to its propulsion elements, a redesigned ET and twin SRBs.

Amino acid, mineral and fatty acid content of pumpkin seeds (Cucurbita spp) and Cyperus esculentus nuts in the Republic of Niger.

PubMed

Glew, R H; Glew, R S; Chuang, L-T; Huang, Y-S; Millson, M; Constans, D; Vanderjagt, D J

2006-06-01

Dried seeds and nuts are widely consumed by indigenous populations of the western Sahel, especially those who inhabit rural areas. In light of the need for quantitative information regarding the content of particular nutrients in these plant foods, we collected dried pumpkin (Cucurbita spp) seeds and nuts of Cyperus esculentus in the Republic of Niger and analyzed them for their content of essential amino acids, minerals and trace elements, and fatty acids. On a dry weight basis, pumpkin seed contained 58.8% protein and 29.8% fat. However, the lysine score of the protein was only 65% relative to the FAO/WHO protein standard. The pumpkin seed contained useful amounts of linoleic (92 microg/g dry weight) and the following elements (on a microg per g dry weight basis): potassium (5,790), magnesium (5,690), manganese (49.3), zinc (113), selenium (1.29), copper (15.4), chromium (2.84), and molybdenum (0.81), but low amounts of calcium and iron. Except for potassium (5,573 microg/g dry weight) and chromium (2.88 microg/g dry weight), the C. esculentis nuts contained much less of these same nutrients compared to pumpkin seeds. In conclusion, pumpkin seeds represent a useful source of many nutrients essential to humans. The data in this report should of practical value to public health officials in rural areas of sub-Saharan Africa.

Rare earth and precious elements in the urban sewage sludge and lake surface sediments under anthropogenic influence in the Republic of Benin.

PubMed

Yessoufou, Arouna; Ifon, Binessi Edouard; Suanon, Fidèle; Dimon, Biaou; Sun, Qian; Dedjiho, Comlan Achille; Mama, Daouda; Yu, Chang-Ping

2017-11-09

Nowadays, sewage sludge and water bodies are subjected to heavy pollution due to rapid population growth and urbanization. Heavy metal pollution represents one of the main challenges threatening our environment and the ecosystem. The present work aims to evaluate the contamination state of the sewage sludge and lake sediments in the Republic of Benin. Twenty metallic elements including 15 rare earth elements (Eu, Sb, Cs, Nd, Pr, Gd, La, Ce, Tb, Sm, Dy, Ho, Eu, Yb, and Lu) and five precious elements (Ag, Au, Pd, Pt, and Ru) were investigated using inductive plasma-mass spectrometry. Results showed broad range concentrations of the elements. Ce, La, and Nd were present in both sediments and sewage sludge at concentrations ranging 5.80-41.30 mg/kg dry matter (DM), 3.23-15.60 mg/kg DM, and 2.74-19.26 mg/kg DM, respectively. Pr, Sm, Gd, Tb, Dy, Eu, Er, Yb, Cs, Ho, and Tm concentrations were lower (0.02-5.94 mg/kg DM). Among precious elements, Ag was detected at the highest concentration in all sites (0.43-4.72 mg/kg DM), followed by Pd (0.20-0.57 mg/kg DM) and Au (0.01-0.57 mg/kg DM). Ru and Pt concentrations were < 0.20 mg/kg DM in all samples. Pollution indices and enrichment factor indicated a strong to severe enrichment of the elements, mainly Ce and precious elements in both sediments and sewage sludge. This revealed a growing anthropogenic input which was also implied by principal component analysis. The evaluation of pollution loading index (PLI) indicated a moderate to strong contamination (0.12 ≤ PLI ≤ 0.58; 37 ≤ PLI ≤ 114, respectively, for rare earth elements and precious elements), while the degree of contamination indicated a moderate polymetallic contamination for rare earth elements and significant contamination for precious elements.

Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lo, Yuan-Hung; Ho, Po-Chun; Chen, Min-Shan

Highlights: Black-Right-Pointing-Pointer Proliferating Cell Nuclear Antigen (PCNA) is phosphorylated at Y114. Black-Right-Pointing-Pointer Phospho-Y114 of PCNA is not required for cell proliferation for normal growth. Black-Right-Pointing-Pointer MCE during adipogenesis is abolished in the lack of the phosphorylation. Black-Right-Pointing-Pointer Homozygous Y114F mice are resistant to high fat diet induced obesity. Black-Right-Pointing-Pointer Our results shed light on the interface between proliferation and differentiation. -- Abstract: Clonal proliferation is an obligatory component of adipogenesis. Although several cell cycle regulators are known to participate in the transition between pre-adipocyte proliferation and terminal adipocyte differentiation, how the core DNA synthesis machinery is coordinately regulated in adipogenesismore » remains elusive. PCNA (Proliferating Cell Nuclear Antigen) is an indispensable component for DNA synthesis during proliferation. Here we show that PCNA is subject to phosphorylation at the highly conserved tyrosine residue 114 (Y114). Replacing the Y114 residue with phenylalanine (Y114F), which is structurally similar to tyrosine but cannot be phosphorylated, does not affect normal animal development. However, when challenged with high fat diet, mice carrying homozygous Y114F alleles (PCNA{sup F/F}) are resistant to adipose tissue enlargement in comparison to wild-type (WT) mice. Mouse embryonic fibroblasts (MEFs) harboring WT or Y114F mutant PCNA proliferate at similar rates. However, when subjected to adipogenesis induction in culture, PCNA{sup F/F} MEFs are not able to re-enter the cell cycle and fail to form mature adipocytes, while WT MEFs undergo mitotic clonal expansion in response to the adipogenic stimulation, accompanied by enhanced Y114 phosphorylation of PCNA, and differentiate to mature adipocytes. Consistent with the function of Y114 phosphorylation in clonal proliferation in adipogenesis, fat tissues isolated from WT mice contain significantly more adipocytes than those isolated from PCNA{sup F/F} mice. This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.« less

Extended mid-infrared emission from VV 114: Probing the birth of a ULIRG

NASA Astrophysics Data System (ADS)

Le Floc'h, E.; Charmandaris, V.; Laurent, O.; Mirabel, I. F.; Gallais, P.; Sauvage, M.; Vigroux, L.; Cesarsky, C.

2002-08-01

We present our 5-16 mu m spectro-imaging observations of VV 114, an infrared luminous early-stage merger of two galaxies VV 114E and VV 114W, taken with the ISOCAM camera on-board the Infrared Space Observatory. We find that only 40% of the mid-infrared (MIR) flux is associated with a compact nuclear region of VV 114E, while the rest of the emission originates from a rather diffuse component extended over several kpc in the regions between VV 114E and VV 114W. This is in stark contrast with the very compact MIR starbursts usually seen in luminous and ultraluminous infrared galaxies. A secondary peak of MIR emission is associated with an extra-nuclear star forming region of VV 114W which displays the largest Hα equivalent width in the whole system. Comparing our data with the distribution of the molecular gas and cold dust, as well as with radio observations, it becomes evident that the conversion of molecular gas into stars can be triggered over large areas at the very first stages of an interaction. This extended star formation along with the extreme nuclear starburst observed in VV 114E can easily lead to the heating of dust grains found in the tidally disturbed disks of the progenitor galaxies and subsequently traced via their MIR emission. The presence of a very strong continuum at the 5-6.5 mu m range in the spectrum of VV 114E indicates that an enshrouded active galactic nucleus (AGN) may contribute to ~ 40% of its MIR flux. We finally note that the relative variations in the UV to radio spectral properties between VV 114E and VV 114W provide evidence that the extinction-corrected star formation rate of similar objects at high z, such as those detected in optical deep surveys, cannot be accurately derived from their rest-frame UV properties. Based on observations with the ISO satellite, an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, the Netherlands and the United Kingdom) and with the participation of ISAS and NASA.

Monitoring flux through the oxidative pentose phosphate pathway using [1-14C]gluconate.

PubMed

Garlick, Andrew P; Moore, Catherine; Kruger, Nicholas J

2002-12-01

The aim of this work was to examine the metabolism of exogenous gluconate by a 4-day-old cell suspension culture of Arabidopsis thaliana (L.) Heynh. Release of (14)CO(2) from [1-(14)C]gluconate was dependent on the concentration in the medium and could be resolved into a substrate-saturable component (apparent K(m) of approximately 0.4 mM) and an unsaturable component. At an external concentration of 0.3 mM, the rate of decarboxylation of applied gluconate was 0.2% of the rate of oxygen consumption by the cells. There was no effect of 0.3 mM gluconate on the rate of oxygen consumption, or on the rate of (14)CO(2) release from either [1-(14)C]glucose or [6-(14)C]glucose by the culture. The following observations argue that gluconate taken up by the cells is metabolised by direct phosphorylation to 6-phosphogluconate and subsequent decarboxylation through 6-phosphogluconate dehydrogenase. First, more than 95% of the label released from [1-(14)C]gluconate during metabolism by the cell culture was recovered as (14)CO(2). Secondly, inhibition of the oxidative pentose phosphate pathway (OPPP) by treatment with 6-aminonicotinamide preferentially inhibited release of (14)CO(2) from [1-(14)C]gluconate relative to that from [1-(14)C]glucose. Thirdly, perturbation of glucose metabolism by glucosamine did not affect (14)CO(2) from [1-(14)C]gluconate. Fourth, stimulation of the OPPP by phenazine methosulphate stimulated release of (14)CO(2) from [1-(14)C]gluconate to a far greater extent than that from [1-(14)C]glucose. It is proposed that measurement of (14)CO(2) from [1-(14)C]gluconate provides a simple and sensitive technique for monitoring flux through the OPPP pathway in plants.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Yi; Keller, Jonathan; Zhang, Zhiwei

The planetary load sharing characteristics of wind turbine gearboxes supported by cylindrical roller bearings (CRBs) and preloaded tapered roller bearings (TRBs) when subjected to rotor moments are compared in this work. Planetary bearing loads were measured in field-representative dynamometer tests and compared to loads predicted by finite-element models. Load sharing was significantly improved with preloaded TRBs. In pure torque conditions, the upwind planet bearing loads in the gearbox with preloaded TRBs were a maximum of 1.14 compared to 1.47 in the gearbox with CRBs. Consequently, the predicted fatigue life of the complete set of planetary bearings for the gearbox withmore » preloaded TRBs is 3.5 times greater than that of the gearbox with CRBs.« less

Local Distribution Fiber Optic Cable Communication System.

DTIC Science & Technology

1981-03-20

T 1 0 1 72 2304 T 1 0 0 36 1152 T 0 1 1 18 576 T 0 1 0 9 288 T 0 0 1 128 4096 S 1 1 0 64 2048 S 1 0 1 48 1536 S 1 0 0 32 1024 S 0 1 1 16 512 S 0 1 0a...channels. For 32 kb/s channels, the trunk transmission rates are 256, 288, 512, 576, 1024, 1152, 1536, 2048 , and 2304 kb/s. The DGM functions as...connectors will remain mated, even under transport conditions. In the MP shelter, power cables are drawn from the VDI /CAP nest. Extra flexible hook-up

Vapor-liquid equilibria for hydrogen fluoride + 1,1-difluoroethane at 288.23 and 298.35 K

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, J.; Kim, H.; Lim, J.S.

1997-07-01

Isothermal vapor-liquid equilibria for hydrogen fluoride + 1,1-difluoroethane at 288.23 and 298.35 K were measured using a circulation type apparatus equipped with an equilibrium view cell. The compositions of both vapor and liquid phases were analyzed by an on-line gas chromatographic method. They were compared with PTx equilibrium data measured by the total pressure method. The experimental data were correlated with Anderko`s equation of state using the Wong-Sandler mixing rule as well as the van der Waals one-fluid mixing rule. The Wong-Sandler mixing rule gives better results, and the relevant parameters are presented.

Saccharomyces cerevisiae KNU5377 stress response during high-temperature ethanol fermentation.

PubMed

Kim, Il-Sup; Kim, Young-Saeng; Kim, Hyun; Jin, Ingnyol; Yoon, Ho-Sung

2013-03-01

Fuel ethanol production is far more costly to produce than fossil fuels. There are a number of approaches to cost-effective fuel ethanol production from biomass. We characterized stress response of thermotolerant Saccharomyces cerevisiae KNU5377 during glucose-based batch fermentation at high temperature (40°C). S. cerevisiae KNU5377 (KNU5377) transcription factors (Hsf1, Msn2/4, and Yap1), metabolic enzymes (hexokinase, glyceraldehyde-3-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase, and alcohol dehydrogenase), antioxidant enzymes (thioredoxin 3, thioredoxin reductase, and porin), and molecular chaperones and its cofactors (Hsp104, Hsp82, Hsp60, Hsp42, Hsp30, Hsp26, Cpr1, Sti1, and Zpr1) are upregulated during fermentation, in comparison to S. cerevisiae S288C (S288C). Expression of glyceraldehyde-3-phosphate dehydrogenase increased significantly in KNU5377 cells. In addition, cellular hydroperoxide and protein oxidation, particularly lipid peroxidation of triosephosphate isomerase, was lower in KNU5377 than in S288C. Thus, KNU5377 activates various cell rescue proteins through transcription activators, improving tolerance and increasing alcohol yield by rapidly responding to fermentation stress through redox homeostasis and proteostasis.

Comparative analysis of mitochondrial genomes between the hau cytoplasmic male sterility (CMS) line and its iso-nuclear maintainer line in Brassica juncea to reveal the origin of the CMS-associated gene orf288.

PubMed

Heng, Shuangping; Wei, Chao; Jing, Bing; Wan, Zhengjie; Wen, Jing; Yi, Bin; Ma, Chaozhi; Tu, Jinxing; Fu, Tingdong; Shen, Jinxiong

2014-04-30

Cytoplasmic male sterility (CMS) is not only important for exploiting heterosis in crop plants, but also as a model for investigating nuclear-cytoplasmic interaction. CMS may be caused by mutations, rearrangement or recombination in the mitochondrial genome. Understanding the mitochondrial genome is often the first and key step in unraveling the molecular and genetic basis of CMS in plants. Comparative analysis of the mitochondrial genome of the hau CMS line and its maintainer line in B. juneca (Brassica juncea) may help show the origin of the CMS-associated gene orf288. Through next-generation sequencing, the B. juncea hau CMS mitochondrial genome was assembled into a single, circular-mapping molecule that is 247,903 bp in size and 45.08% in GC content. In addition to the CMS associated gene orf288, the genome contains 35 protein-encoding genes, 3 rRNAs, 25 tRNA genes and 29 ORFs of unknown function. The mitochondrial genome sizes of the maintainer line and another normal type line "J163-4" are both 219,863 bp and with GC content at 45.23%. The maintainer line has 36 genes with protein products, 3 rRNAs, 22 tRNA genes and 31 unidentified ORFs. Comparative analysis the mitochondrial genomes of the hau CMS line and its maintainer line allowed us to develop specific markers to separate the two lines at the seedling stage. We also confirmed that different mitotypes coexist substoichiometrically in hau CMS lines and its maintainer lines in B. juncea. The number of repeats larger than 100 bp in the hau CMS line (16 repeats) are nearly twice of those found in the maintainer line (9 repeats). Phylogenetic analysis of the CMS-associated gene orf288 and four other homologous sequences in Brassicaceae show that orf288 was clearly different from orf263 in Brassica tournefortii despite of strong similarity. The hau CMS mitochondrial genome was highly rearranged when compared with its iso-nuclear maintainer line mitochondrial genome. This study may be useful for studying the mechanism of natural CMS in B. juncea, performing comparative analysis on sequenced mitochondrial genomes in Brassicas, and uncovering the origin of the hau CMS mitotype and structural and evolutionary differences between different mitotypes.

Hydrocortisone selectively inhibits IgE-dependent arachidonic acid release from rat peritoneal mast cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heiman, A.S.; Crews, F.T.

Purified rat mst cells were used to study the effects of antiinflammatory steroids on the release of (1-14C)-arachidonic acid ((1-14C)AA) and metabolites. Mast cell were incubated overnight with glucocorticoids, (1-14C)AA incorporated into cellular phospholipids and the release of (1-14C)AA, and metabolites determined using a variety of secretagogues. Release of (1-14C)AA and metabolites by concanavalin A, the antigen ovalbumin and anti-immunoglobulin E antibody was markedly reduced by glucocorticoid treatment. Neither the total incorporation of (1-14C)AA nor the distribution into phospholipids was altered by hydrocortisone pretreatment. Glucocorticoid pretreatment did not alter (1-14C)AA release stimulated by somatostatin, compound 48/80, or the calcium ionophore,more » A23187. These data indicate that antiinflammatory steroids selectively inhibit immunoglobulin dependent release of arachidonic acid from rat mast cells. These findings question the role of lipomodulin and macrocortin as general phospholipase inhibitors and suggest that they may be restricted to immunoglobulin stimuli.« less

A Dual-Layer Transducer Array for 3-D Rectilinear Imaging

PubMed Central

Yen, Jesse T.; Seo, Chi Hyung; Awad, Samer I.; Jeong, Jong S.

2010-01-01

2-D arrays for 3-D rectilinear imaging require very large element counts (16,000–65,000). The difficulties in fabricating and interconnecting 2-D arrays with a large number of elements (>5,000) have limited the development of suitable transducers for 3-D rectilinear imaging. In this paper, we propose an alternative solution to this problem by using a dual-layer transducer array design. This design consists of two perpendicular 1-D arrays for clinical 3-D imaging of targets near the transducer. These targets include the breast, carotid artery, and musculoskeletal system. This transducer design reduces the fabrication complexity and the channel count making 3-D rectilinear imaging more realizable. With this design, an effective N × N 2-D array can be developed using only N transmitters and N receivers. This benefit becomes very significant when N becomes greater than 128, for example. To demonstrate feasibility, we constructed a 4 × 4 cm prototype dual-layer array. The transmit array uses diced PZT-5H elements, and the receive array is a single sheet of undiced P[VDF-TrFE] copolymer. The receive elements are defined by the copper traces on the flexible interconnect circuit. The measured −6 dB fractional bandwidth was 80% with a center frequency of 4.8 MHz. At 5 MHz, the nearest neighbor crosstalk of the PZT array and PVDF array was −30.4 ± 3.1 dB and −28.8 ± 3.7 dB respectively. This dual-layer transducer was interfaced with an Ultrasonix Sonix RP system, and a synthetic aperture 3-D data set was acquired. We then performed off-line 3-D beamforming to obtain volumes of nylon wire targets. The theoretical lateral beamwidth was 0.52 mm compared to measured beamwidths of 0.65 mm and 0.67 mm in azimuth and elevation respectively. 3-D images of an 8 mm diameter anechoic cyst phantom were also acquired. PMID:19213647

Tracing cadmium, zinc and lead sources in bivalves from the coasts of western Canada and the USA using isotopes

NASA Astrophysics Data System (ADS)

Shiel, Alyssa E.; Weis, Dominique; Orians, Kristin J.

2012-01-01

Environmental monitoring and remediation require techniques to identify the source and fate of metals emissions. The measurement of heavy metal isotopic signatures, made possible by the advent of the MC-ICP-MS, is a powerful new geochemical tool, which may be used to trace the source of these metals in the environment. In a multi-tracer study, Cd, Zn and Pb isotopic compositions (MC-ICP-MS) and elemental concentrations (HR-ICP-MS) are used to distinguish between natural and anthropogenic sources of these metals in bivalves collected from western Canada (British Columbia), Hawaii, and the USA East Coast. Variability in the δ 114/110Cd values of bivalves (-1.20‰ to -0.09‰) is attributed to differences in the relative contributions of Cd from natural and anthropogenic sources between sites. Cadmium isotopic compositions (δ 114/110Cd = -0.69‰ to -0.09‰) identify high Cd levels in B.C. oysters as primarily natural (i.e., upwelling of Cd rich intermediate waters in the North Pacific), with some variability attributed to anthropogenic sources (e.g., mining and smelting). Variability in the δ 66/64Zn values exhibited by the B.C. bivalves is relatively small (0.28-0.36‰). Despite the low Pb levels found in B.C. oysters, Pb isotopes are used to identify emissions from industrial processes and the consumption of unleaded gasoline and diesel fuel as significant metal sources. Although the Cd concentrations of the USA East Coast bivalves are primarily lower than those of B.C. oysters, their relatively light Cd isotopic compositions (δ 114/110Cd = -1.20‰ to -0.54‰) indicate the significance of anthropogenic Cd sources and are attributed to the high prevalence of industry on this coast. The δ 114/110Cd values of USA East Coast bivalves include the lightest ever reported, with the exception of values reported for extraterrestrial materials. In addition, the Pb isotopic compositions of bivalves from the USA East Coast indicate Pb emissions from the combustion of coal are an important source of Pb, consistent with the high consumption of coal for power production on this coast. This study demonstrates the effective use of Cd and Zn isotopes to trace anthropogenic sources in the environment and the benefit of combining these tools with Pb "fingerprinting" techniques.

Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome.

PubMed

Tolunay, Harun Egemen; Şükür, Yavuz Emre; Ozkavukcu, Sinan; Seval, Mehmet Murat; Ateş, Can; Türksoy, Vugar Ali; Ecemiş, Tolga; Atabekoğlu, Cem Somer; Özmen, Batuhan; Berker, Bülent; Sönmezer, Murat

2016-03-01

To assess the effects of heavy metal and trace element concentrations in blood and follicular fluid on assisted reproductive technology cycle outcome. A prospective study was conducted between January 2012 and July 2012 in a university hospital infertility clinic. One hundred and one patients with unexplained infertility who underwent intracytoplasmic sperm injection using GnRH-antagonist protocol were recruited. Concentrations of four toxic metals (Cd, Pb, Hg, As) and three trace elements (Cu, Zn, Fe) were measured both in blood and follicular fluid specimens. Patients were evaluated in two groups; the study group consisted of patients with ongoing pregnancy (n=20) and the reference group consisted of patients experienced assisted reproductive technology failure, miscarriage or biochemical pregnancy (n=81). Demographics and cycle parameters were comparable between the groups except for median number of day 3 Grade A embryos. Statistically significant negative correlations were found between blood Pb levels and number of MII oocytes, implantation, clinical pregnancy and ongoing pregnancy rates. Results of the log binomial regression revealed 2.2% lower risk for ongoing pregnancy for each 1μg/dL higher blood Pb concentration while holding the other variables in the model constant (RR 0.978; 95% CI 0.956-0.998; P=.041). Also, the results revealed 71.9% lower risk for ongoing pregnancy for each 1μg/dL higher follicular fluid Cu concentration while holding the other variables in the model constant (RR 0.288; 95% CI 0.085-0.92; P=.039). Blood concentrations of Pb and follicular fluid concentrations of Cu seem to have significant impacts on assisted reproductive technology cycle outcome. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

General Lack of Correlations between Age and Signs of the Metabolic Syndrome in Subjects with Non-diabetic Fasting Glucose Values.

PubMed

Preuss, Harry G; Mrvichin, Nate; Clouatre, Dallas; Bagchi, Debasis; Preuss, Jeffrey M; Perricone, Nicholas V; Swaroop, Anand; Kaats, Gilbert R

2017-01-01

Insulin resistance and advancing age are well-recognized risk factors for metabolic syndrome. Recent reports indicate that fasting glucose levels in non-diabetic patients correlate appropriately with the development of certain elements in metabolic syndrome, which suggest a cause-effect relationship with insulin resistance. The present investigation assessed whether a significant association exists between chronological age and various elements of metabolic syndrome in this same group of subjects possessing non-diabetic fasting glucose levels. Baseline data were taken from 288 subjects (age 17-87 years) with fasting glucose levels ≤ 125 mg/dl. Correlations between chronological age and different metabolic parameters were assessed to determine any statistically significant relationships and compare these with previously demonstrated metabolic parameters. With the exception of systolic blood pressure, the following correlations between age and components of metabolic syndrome were not significant or even significant in the opposite direction compared to those found in the same population using fasting glucose as the independent variable: body weight, body fat, diastolic blood pressure, white blood cell count (WBC)/neutrophil count, and circulating levels of insulin, high-density lipoprotein (HDL) cholesterol, triglycerides, high-sensitivity C-reactive protein (hs-CRP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Although systolic blood pressure still increased, it was to a lesser extent than might be expected. In the present investigation, a cross-sectional analysis was carried out over a wide age range of subjects. It is noteworthy that fasting glucose levels and the other major elements of metabolic syndrome did not change significantly with advancing age. These results demonstrate that decreasing insulin resistance and fasting glucose levels may be an important way to overcome the adverse effects and perturbations of advancing age-induced consequences of metabolic syndrome.

40 CFR 11.4 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Definitions. 11.4 Section 11.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SECURITY CLASSIFICATION REGULATIONS... revelation of sensitive intelligence operations; and the disclosure of scientific or technological...

40 CFR 11.4 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Definitions. 11.4 Section 11.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SECURITY CLASSIFICATION REGULATIONS... revelation of sensitive intelligence operations; and the disclosure of scientific or technological...

40 CFR 11.4 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Definitions. 11.4 Section 11.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SECURITY CLASSIFICATION REGULATIONS... revelation of sensitive intelligence operations; and the disclosure of scientific or technological...

40 CFR 11.4 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Definitions. 11.4 Section 11.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SECURITY CLASSIFICATION REGULATIONS... revelation of sensitive intelligence operations; and the disclosure of scientific or technological...

Kinetic study of benzyl [1-14C]acetate as a potential probe for astrocytic energy metabolism in the rat brain: Comparison with benzyl [2-14C]acetate.

PubMed

Okada, Maki; Yanamoto, Kazuhiko; Kagawa, Tomohiko; Yoshino, Keiko; Hosoi, Rie; Abe, Kohji; Zhang, Ming-Rong; Inoue, Osamu

2016-02-01

Brain uptake of [(14)C]acetate has been reported to be a useful marker of astrocytic energy metabolism. In addition to uptake values, the rate of radiolabeled acetate washout from the brain appears to reflect CO2 exhaustion and oxygen consumption in astrocytes. We measured the time-radioactivity curves of benzyl [1-(14)C]acetate ([1-(14)C]BA), a lipophilic probe of [1-(14)C]acetate, and compared it with that of benzyl [2-(14)C]acetate ([2-(14)C]BA) in rat brains. The highest brain uptake was observed immediately after injecting either [1-(14)C]BA or [2-(14)C]BA, and both subsequently disappeared from the brain in a single-exponential manner. Estimated [1-(14)C]BA washout rates in the cerebral cortex and cerebellum were higher than those of [2-(14)C]BA. These results suggested that [1-(14)C]BA could be a useful probe for estimating the astrocytic oxidative metabolism. The [1-(14)C]BA washout rate in the cerebral cortex of immature rats was lower than that of mature rats. An autoradiographic study showed that the washout rates of [1-(14)C]BA from the rat brains of a lithium-pilocarpine-induced status epilepticus model were not significantly different from the values in control rat brains except for the medial septal nucleus. These results implied that the enhancement of amino acid turnover rate rather than astrocytic oxidative metabolism was increased in status epilepticus. © The Author(s) 2015.

49 CFR 572.114 - Thorax.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Thorax. 572.114 Section 572.114 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES Side Impact Hybrid Dummy 50th...

49 CFR 572.114 - Thorax.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Thorax. 572.114 Section 572.114 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES Side Impact Hybrid Dummy 50th...

49 CFR 572.114 - Thorax.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Thorax. 572.114 Section 572.114 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES Side Impact Hybrid Dummy 50th...

49 CFR 572.114 - Thorax.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Thorax. 572.114 Section 572.114 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES Side Impact Hybrid Dummy 50th...

49 CFR 572.114 - Thorax.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Thorax. 572.114 Section 572.114 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES Side Impact Hybrid Dummy 50th...

7 CFR 1463.114 - Appeals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Appeals. 1463.114 Section 1463.114 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS 2005-2014 TOBACCO TRANSITION PROGRAM Tobacco Transition...

STS-114 with Expedition 7 during ASC/CAP/OES Training.

NASA Image and Video Library

2002-11-12

JSC2002-02020 (12 November 2002) --- The STS-114 and Expedition Seven crews, attired in training versions of the full-pressure launch and entry suit, pose for a group photo prior to a training session in the Space Vehicle Mockup Facility at the Johnson Space Center (JSC). From the left are astronauts Soichi Noguchi, Stephen K. Robinson, both STS-114 mission specialists; James M. Kelly, STS-114 pilot; Eileen M. Collins, STS-114 mission commander; Edward T. Lu, Expedition Seven flight engineer; cosmonauts Yuri I. Malenchenko, Expedition Seven mission commander; and Alexander Y. Kaleri, Expedition Seven flight engineer. Noguchi represents Japan’s National Space Development Agency (NASDA). Malenchenko and Kaleri represent Rosaviakosmos.

Cadmium and zinc isotopes of organic-rich marine sediments during Oceanic Anoxic Event 2

NASA Astrophysics Data System (ADS)

Sweere, T.; Dickson, A. J.; Jenkyns, H. C.; Porcelli, D.; Henderson, G. M.; van den Boorn, S.

2017-12-01

Mesozoic Oceanic Anoxic Events (OAEs) are characterized by widespread deposition of organic-rich sediments and the spread of low-oxygen marine environments. To drive and sustain unusually efficient carbon-burial during these events requires high export productivity rates, which has to be supported by an abundance of nutrients in the surface ocean. The presence of redox-sensitive bio-essential micronutrients may be particularly important, and potentially bio-limiting, during such events as they may be drawn down into sediment under low-oxygen conditions. Cadmium and zinc isotopes have potential as tracers for past (micro)nutrient dynamics considering their nutrient-like distribution in the modern ocean and isotope fractionation with uptake by primary producers. The modern deep ocean is generally well mixed for Cd and Zn while short-term cycling of these elements in the surface ocean imposes regional variation. Additional regional variation may be caused by sulfide formation and associated isotope fractionation in euxinic environments. The impact of such regional environmental conditions on the Cd- and Zn-isotope composition of the sediment therefore needs to be addressed in order to explore the use of these elements as a proxy for past nutrient conditions. Here we present an extensive dataset of cadmium- and zinc-isotope compositions of organic-rich marine sediments from different basins deposited during OAE 2 (Late Cretaceous). This comparison highlights regional differences in Cd- and Zn-isotope compositions. However, despite regional environmental controls, a correlation between δ114Cd and δ66Zn across the different sites is observed, which implies a largely similar control on the two isotope systems. When regional environmental controls are accounted for, the data may provide insight in the δ66Zn and δ114Cd evolution of global seawater during OAE 2 as well as information on the global cycling of redox-sensitive micronutrients during the event

Proximate and elemental composition of Chamelea gallina from the southern coast of the Marmara Sea (Turkey).

PubMed

Arik Colakoglu, Fatma; Ormanci, Hasan Basri; Berik, Nermin; Kunili, Ibrahim Ender; Colakoglu, Serhat

2011-11-01

The venerid clam Chamelea gallina is a popular and economic foodstuff around the Mediterranean countries especially in Italy, Spain, and France. The aim of this study is to evaluate the nutritional quality of striped venus of Southern Marmara. Samples were harvested seasonally at five stations and analyzed to determine meat yield, proximate, and elemental composition. According to the results, meat yield ranged from 20.24% to 29.94%. Means of water, protein, lipid, and ash content were 67%, 10.12%, 2.57%, and 1.66%, respectively. The mean concentrations (mg/kg wet weight) of elements in tissues are as follows: B: 2.37-4.24; Cr: 0-0.76; Co: 0-0.43; Cu: 0.71-5.30; Mn: 0.30-5.94; Zn: 13.08-77.76; Ni: 0-1.22; Fe: 2.46-114.22; Al: 1.23-75.49; Pb: 0.18-3.24; Ba: 0.66-15.97; Cd: 0.04-0.69. Among the reported metal levels, only Pb and Zn in two stations exceeded the maximum critical concentrations enforced by Turkish legislation and European Commission. Therefore, we report that striped venus from Southern Marmara Sea, in general, are safe for human consumption; nonetheless, Pb and Zn levels should be closely monitored in the future.

14 CFR 1240.114 - Delegation of authority.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Delegation of authority. 1240.114 Section 1240.114 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INVENTIONS AND... Associate Administrator for Aerospace Technology and the Chairperson, Inventions and Contributions Board...

14 CFR 1240.114 - Delegation of authority.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Delegation of authority. 1240.114 Section 1240.114 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INVENTIONS AND... Associate Administrator for Aerospace Technology and the Chairperson, Inventions and Contributions Board...

7 CFR 3015.114 - Budgets-general.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Budgets-general. 3015.114 Section 3015.114 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Programmatic Changes and Budget Revisions...

40 CFR 11.4 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Definitions. 11.4 Section 11.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL SECURITY CLASSIFICATION REGULATIONS.... Confidential refers to that national security information or material which requires protection. The test for...

17 CFR 200.114 - Sanctions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Sanctions. 200.114 Section 200.114 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

17 CFR 200.114 - Sanctions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Sanctions. 200.114 Section 200.114 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

17 CFR 200.114 - Sanctions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Sanctions. 200.114 Section 200.114 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

17 CFR 200.114 - Sanctions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Sanctions. 200.114 Section 200.114 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

17 CFR 200.114 - Sanctions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Sanctions. 200.114 Section 200.114 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

19 CFR 207.114 - Initial determination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Initial determination. 207.114 Section 207.114 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER INJURY TO DOMESTIC INDUSTRIES RESULTS FROM IMPORTS SOLD AT LESS THAN FAIR VALUE OR FROM...

7 CFR 4288.114-4288.119 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false [Reserved] 4288.114-4288.119 Section 4288.114-4288.119 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

7 CFR 4288.114-4288.119 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false [Reserved] 4288.114-4288.119 Section 4288.114-4288.119 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

7 CFR 4288.114-4288.119 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false [Reserved] 4288.114-4288.119 Section 4288.114-4288.119 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment...

40 CFR 405.114 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 405.114 Section 405.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS DAIRY PRODUCTS PROCESSING POINT SOURCE CATEGORY Condensed Whey...

42 CFR 418.114 - Condition of participation: Personnel qualifications.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 3 2011-10-01 2011-10-01 false Condition of participation: Personnel qualifications. 418.114 Section 418.114 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM HOSPICE CARE Conditions of participation...

38 CFR 52.30 - Recognition and certification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Healthcare Group (114), of the action taken. (2) For each facility recognized as a State home, the director..., Geriatrics and Extended Care Strategic Healthcare Group (114), of the certification, provisional... Chief Consultant, Geriatrics and Extended Care Strategic Healthcare Group (114). The letter will include...

42 CFR 418.114 - Condition of participation: Personnel qualifications.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Condition of participation: Personnel qualifications. 418.114 Section 418.114 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) HOSPICE CARE Conditions of...

42 CFR 418.114 - Condition of participation: Personnel qualifications.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Condition of participation: Personnel qualifications. 418.114 Section 418.114 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) HOSPICE CARE Conditions of...

42 CFR 418.114 - Condition of participation: Personnel qualifications.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 3 2013-10-01 2013-10-01 false Condition of participation: Personnel qualifications. 418.114 Section 418.114 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) HOSPICE CARE Conditions of...

24 CFR 257.114 - Appraisal.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Appraisal. 257.114 Section 257.114 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

24 CFR 257.114 - Appraisal.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Appraisal. 257.114 Section 257.114 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

24 CFR 4001.114 - Appraisal.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Appraisal. 4001.114 Section 4001.114 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... shall be conducted in accordance with Uniform Standards of Professional Appraisal Practice (USPAP) but...

24 CFR 4001.114 - Appraisal.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Appraisal. 4001.114 Section 4001.114 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... shall be conducted in accordance with Uniform Standards of Professional Appraisal Practice (USPAP) but...

KSC-02pd1845

NASA Image and Video Library

2002-11-08

KENNEDY SPACE CENTER, FLA. - At the Space Station Processing Facility, STS-114 Mission Specialist Stephen Robinson (center), dressed in cleanroom attire, participates in familiarization activities on equipment that will fly on the STS-114 mission, as support personnel look on. STS-114 is a utilization and logistics flight that will carry Multi-Purpose Logistics Module Raffaello and the External Stowage Platform (ESP-2), as well as the Expedition 7 crew, to the International Space Station. Launch of STS-114 is currently targeted for March 1, 2003.

KSC-02pd1843

NASA Image and Video Library

2002-11-08

KENNEDY SPACE CENTER, FLA. - At the SPACEHAB facility in Cape Canaveral, STS-114 Pilot James Kelly (left), Commander Eileen Collins (center) and a technician participate in familiarization activities on the module that will fly on the STS-114 mission. STS-114 is a utilization and logistics flight that will carry Multi-Purpose Logistics Module Raffaello and the External Stowage Platform (ESP-2), as well as the Expedition 7 crew, to the International Space Station. Launch of STS-114 is currently targeted for March 1, 2003.

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Wendy Lawrence autographs the sign presented to workers in the Orbiter Processing Facility. Lawrence is a new addition to the crew. The STS-114 crew is at KSC to take part in crew equipment and orbiter familiarization.

NASA Image and Video Library

2003-10-30

KENNEDY SPACE CENTER, FLA. - STS-114 Mission Specialist Wendy Lawrence autographs the sign presented to workers in the Orbiter Processing Facility. Lawrence is a new addition to the crew. The STS-114 crew is at KSC to take part in crew equipment and orbiter familiarization.

Stimulation of Cortical Myosin Phosphorylation by p114RhoGEF Drives Cell Migration and Tumor Cell Invasion

PubMed Central

Zihni, Ceniz; Harris, Andrew R.; Bailly, Maryse; Charras, Guillaume T.; Balda, Maria S.; Matter, Karl

2012-01-01

Actinomyosin activity is an important driver of cell locomotion and has been shown to promote collective cell migration of epithelial sheets as well as single cell migration and tumor cell invasion. However, the molecular mechanisms underlying activation of cortical myosin to stimulate single cell movement, and the relationship between the mechanisms that drive single cell locomotion and those that mediate collective cell migration of epithelial sheets are incompletely understood. Here, we demonstrate that p114RhoGEF, an activator of RhoA that associates with non-muscle myosin IIA, regulates collective cell migration of epithelial sheets and tumor cell invasion. Depletion of p114RhoGEF resulted in specific spatial inhibition of myosin activation at cell-cell contacts in migrating epithelial sheets and the cortex of migrating single cells, but only affected double and not single phosphorylation of myosin light chain. In agreement, overall elasticity and contractility of the cells, processes that rely on persistent and more constant forces, were not affected, suggesting that p114RhoGEF mediates process-specific myosin activation. Locomotion was p114RhoGEF-dependent on Matrigel, which favors more roundish cells and amoeboid-like actinomyosin-driven movement, but not on fibronectin, which stimulates flatter cells and lamellipodia-driven, mesenchymal-like migration. Accordingly, depletion of p114RhoGEF led to reduced RhoA, but increased Rac activity. Invasion of 3D matrices was p114RhoGEF-dependent under conditions that do not require metalloproteinase activity, supporting a role of p114RhoGEF in myosin-dependent, amoeboid-like locomotion. Our data demonstrate that p114RhoGEF drives cortical myosin activation by stimulating myosin light chain double phosphorylation and, thereby, collective cell migration of epithelial sheets and amoeboid-like motility of tumor cells. PMID:23185572

A Nine Month Photometric Study of the Very Slowly Rotating Asteroid 288 Glauke

NASA Astrophysics Data System (ADS)

Pilcher, Frederick; Franco, Lorenzo; Pravec, Petr

2015-01-01

Fifteen images of the extremely slowly rotating 288 Glauke were obtained every clear night except when the target was very close to the Moon in the interval 2013 Nov. 5 - 2014 July 27 during which the object was more than 60 degrees from the Sun, a total of 187 nights. Tumbling behavior was found, with possible periods near 1170 hours and 740 hours, respectively, and uncertainties probably no larger than 2%. The reliability of tumbling behavior was assessed as PAR=-2. The color index was also determined as V-R=0.48. Magnitude parameters in the V photometric system H=9.99 ± 0.04 and G=0.24 ± 0.02 were found.

45 CFR 400.114 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false [Reserved] 400.114 Section 400.114 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Child Welfare Services § 400...

47 CFR 25.114 - Applications for space station authorizations.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... If the space station can vary channel bandwidth in a particular frequency band with on-board... 47 Telecommunication 2 2014-10-01 2014-10-01 false Applications for space station authorizations. 25.114 Section 25.114 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER...

14 CFR 1230.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Cooperative research. 1230.114 Section 1230... § 1230.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

15 CFR 27.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Cooperative research. 27.114 Section... § 27.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

14 CFR 1230.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Cooperative research. 1230.114 Section 1230... § 1230.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

22 CFR 225.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

22 CFR 225.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

22 CFR 225.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

15 CFR 27.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Cooperative research. 27.114 Section... § 27.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

49 CFR 11.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Cooperative research. 11.114 Section 11.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

16 CFR 1028.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Cooperative research. 1028.114 Section 1028... § 1028.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

49 CFR 11.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 1 2014-10-01 2014-10-01 false Cooperative research. 11.114 Section 11.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

14 CFR 1230.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Cooperative research. 1230.114 Section 1230... § 1230.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

16 CFR 1028.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Cooperative research. 1028.114 Section 1028... § 1028.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

16 CFR 1028.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Cooperative research. 1028.114 Section 1028... § 1028.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

14 CFR 1230.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Cooperative research. 1230.114 Section 1230... § 1230.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

15 CFR 27.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Cooperative research. 27.114 Section... § 27.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

15 CFR 27.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Cooperative research. 27.114 Section... § 27.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

49 CFR 11.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Cooperative research. 11.114 Section 11.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

22 CFR 225.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

49 CFR 11.114 - Cooperative research.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Cooperative research. 11.114 Section 11.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

22 CFR 225.114 - Cooperative research.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Cooperative research. 225.114 Section 225.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

49 CFR 11.114 - Cooperative research.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 1 2013-10-01 2013-10-01 false Cooperative research. 11.114 Section 11.114... research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution is responsible for...

15 CFR 27.114 - Cooperative research.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Cooperative research. 27.114 Section... § 27.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

16 CFR 1028.114 - Cooperative research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Cooperative research. 1028.114 Section 1028... § 1028.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each...

34 CFR 300.114 - LRE requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false LRE requirements. 300.114 Section 300.114 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

40 CFR 420.114 - New source performance standards (NSPS).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 30 2013-07-01 2012-07-01 true New source performance standards (NSPS). 420.114 Section 420.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY Alkaline Cleaning Subcategory...

40 CFR 420.114 - New source performance standards (NSPS).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 29 2011-07-01 2009-07-01 true New source performance standards (NSPS). 420.114 Section 420.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY Alkaline Cleaning Subcategory...

40 CFR 420.114 - New source performance standards (NSPS).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 29 2014-07-01 2012-07-01 true New source performance standards (NSPS). 420.114 Section 420.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY Alkaline Cleaning Subcategory...

40 CFR 420.114 - New source performance standards (NSPS).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true New source performance standards (NSPS). 420.114 Section 420.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY Alkaline Cleaning Subcategory...

40 CFR 420.114 - New source performance standards (NSPS).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 30 2012-07-01 2012-07-01 false New source performance standards (NSPS). 420.114 Section 420.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS IRON AND STEEL MANUFACTURING POINT SOURCE CATEGORY Alkaline Cleaning Subcategory...

40 CFR 417.114 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 417.114 Section 417.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY SO3 Solvent and...

40 CFR 417.114 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 417.114 Section 417.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY SO3 Solvent and...

40 CFR 417.114 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Pretreatment standards for existing sources. 417.114 Section 417.114 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY SO3 Solvent and...