32 CFR 11.6 - Crimes and elements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... must be a direct result of the substance's effect or effects on the human body (e.g., asphyxiation...) The accused caused serious injury to the body or health of one or more persons; (B) The accused... of the body, and serious damage to internal organs. (13) Mutilation or maiming—(i) Elements. (A) The...

KSC-06pd2287

NASA Image and Video Library

2006-10-12

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is transferred from the checkout cell for attaching to its twin solid rocket boosters on the mobile launch platform in highbay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission no. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

40 CFR Table A-7 to Subpart A of... - Data Elements That Are Inputs to Emission Equations and for Which the Reporting Deadline Is March...

Code of Federal Regulations, 2013 CFR

2013-07-01

... mass balance equation. K 98.116(b) Only annual production by product from each EAF (No CEMS). K 98.116... contributed by methane. Y 98.256(f)(7) Only molar volume conversion factor. Y 98.256(f)(10) Only coke burn-off... methane in coking gas. Y 98.256(l)(5) Only molar volume conversion factor. Y 98.256(m)(3) Only total...

Minnesota Water Allocation Law. Volume 1. Commentary on and Abstracts of Treaties, Legislation and Rules.

DTIC Science & Technology

1987-09-01

If applicable) 8c. ADDRESS(City, State, and ZIP Code) 10. SOURCE OF FUNDING NUMBERS ELEMENT NO. NO. NO ACCESSION NO .T 11 TITLE (Include Security...Indians 1-13 Domestic Water Supply on Reservations 1-14 Ground water sources 1-16 Surface water sources 1-16 Commentary on Indian Water Resources 1-17...General’s Office - St. Paul, Minnesota 4 DATA COLLECTION AND REPORT ORGANIZATION Data collected for these volumes result from three primary sources

Remedial Investigation Report, Presidio Main Installation, Presidio of San Francisco. Volume 3: Figures Sections 1-5

DTIC Science & Technology

1997-01-01

0 REFCE02F01 -TDEPTH 0.0’ 0- 0 I° IE T.DEPTH 00 LITOLOGY MS UTHOLOGY MISC Beryllium ɘ.1 Beryllium Y0 A211I RF 5REFCF09 REFCF07 REFCFO4 REFCF01PT 7 T...LITHOLOGY FILL B`EID 1BE11D1Copper 18.300 7.290 f 29𔃼�a a DEPTH 0.2’ 2.2 5.9 * LITOLOGY BE/DU FILL BE/DU S!Copper 32.200 44.400T LF7SBO6 1 11-6 112...34IGATION RESULTS. LC7 Pa 2I 2 2.80 ,%as I.’. aa-2 RA .1" "co SKEET RANGE* 6s4 es2 DEPTH 4.3Ŗ’~iS • • ~ ~ LITOLOGY BEIDU OL At Lead ɟ.440 H A i DEPTH

The optimal thickness of a transmission-mode GaN photocathode

NASA Astrophysics Data System (ADS)

Wang, Xiao-Hui; Shi, Feng; Guo, Hui; Hu, Cang-Lu; Cheng, Hong-Chang; Chang, Ben-Kang; Ren, Ling; Du, Yu-Jie; Zhang, Jun-Ju

2012-08-01

A 150-nm-thick GaN photocathode with a Mg doping concentration of 1.6 × 1017 cm-3 is activated by Cs/O in an ultrahigh vacuum chamber, and a quantum efficiency (QE) curve of the negative electron affinity transmission-mode (t-mode) of the GaN photocathode is obtained. The maximum QE reaches 13.0% at 290 nm. According to the t-mode QE equation solved from the diffusion equation, the QE curve is fitted. From the fitting results, the electron escape probability is 0.32, the back-interface recombination velocity is 5 × 104 cm·s-1, and the electron diffusion length is 116 nm. Based on these parameters, the influence of GaN thickness on t-mode QE is simulated. The simulation shows that the optimal thickness of GaN is 90 nm, which is better than the 150-nm GaN.

25 CFR 290.3 - Information collection.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Information collection. 290.3 Section 290.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES TRIBAL REVENUE ALLOCATION PLANS § 290.3 Information collection. The information collection requirements contained in §§ 290.12, 290.17...

25 CFR 290.3 - Information collection.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Information collection. 290.3 Section 290.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES TRIBAL REVENUE ALLOCATION PLANS § 290.3 Information collection. The information collection requirements contained in §§ 290.12, 290.17...

Thermal Diodes Based on Near-Field Radiation

DTIC Science & Technology

2015-10-01

silicon dioxide (SiO2) for its surface phonon polariton resonances, at 495 cm-1 and 1160 cm-1, known to allow near-field heat transfer. Silicon...transfer between two nano-beams – a fixed and a mobile one. At small gap, evanescent surface polariton resonances at the SiO2 surfaces couple to...the predictions of boundary element method simulations for parallel nanobeams. OCIS codes: (240.5420) Polaritons ; (290.6815) Thermal Emission

Filter Effectiveness Evaluation

DTIC Science & Technology

2013-08-01

Bramer U.S. Army TARDEC Force Projection Technologies Warren, Michigan Contract No. W56HZV-09- C -0100 (WD17-Task 7) UNCLASSIFIED...No. W56HZV-09- C -0100 (WD17-Task 7) SwRI® Project No. 08.14734.17.290 UNCLASSIFIED: Distribution Statement A. Approved for public release...W56HZV-09- C -0100 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Canant, Philip A.; Bessee, Gary B.; Hutzler, Scott A. 5d. PROJECT

Theoretical predictions for α -decay chains of 118 290 -298Og isotopes using a finite-range nucleon-nucleon interaction

NASA Astrophysics Data System (ADS)

Ismail, M.; Adel, A.

2018-04-01

The α -decay half-lives of the recently synthesized superheavy nuclei (SHN) are investigated by employing the density dependent cluster model. A realistic nucleon-nucleon (NN ) interaction with a finite-range exchange part is used to calculate the microscopic α -nucleus potential in the well-established double-folding model. The calculated potential is then implemented to find both the assault frequency and the penetration probability of the α particle by means of the Wentzel-Kramers-Brillouin (WKB) approximation in combination with the Bohr-Sommerfeld quantization condition. The calculated values of α -decay half-lives of the recently synthesized Og isotopes and its decay products are in good agreement with the experimental data. Moreover, the calculated values of α -decay half-lives have been compared with those values evaluated using other theoretical models, and it was found that our theoretical values match well with their counterparts. The competition between α decay and spontaneous fission is investigated and predictions for possible decay modes for the unknown nuclei 118 290 -298Og are presented. We studied the behavior of the α -decay half-lives of Og isotopes and their decay products as a function of the mass number of the parent nuclei. We found that the behavior of the curves is governed by proton and neutron magic numbers found from previous studies. The proton numbers Z =114 , 116, 108, 106 and the neutron numbers N =172 , 164, 162, 158 show some magic character. We hope that the theoretical prediction of α -decay chains provides a new perspective to experimentalists.

KSC-06pd2292

NASA Image and Video Library

2006-10-13

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is mated to its twin solid rocket boosters on the mobile launch platform in high bay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6 feet wide and 154 feet tall. STS-116 will be mission No. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2291

NASA Image and Video Library

2006-10-13

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is mated to its twin solid rocket boosters on the mobile launch platform in high bay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6 feet wide and 154 feet tall. STS-116 will be mission No. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2289

NASA Image and Video Library

2006-10-13

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is mated to its twin solid rocket boosters on the mobile launch platform in high bay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission No. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2290

NASA Image and Video Library

2006-10-13

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is mated to its twin solid rocket boosters on the mobile launch platform in high bay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the space shuttle system at 27.6 feet wide and 154 feet tall. STS-116 will be mission No. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2293

NASA Image and Video Library

2006-10-13

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is mated to its twin solid rocket boosters on the mobile launch platform in high bay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6 feet wide and 154 feet tall. STS-116 will be mission No. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

Finite element validation of stress intensity factor calculation models for thru-thickness and thumb-nail cracks in double edge notch specimens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beres, W.; Koul, A.K.

1994-09-01

Stress intensity factors for thru-thickness and thumb-nail cracks in the double edge notch specimens, containing two different notch radius (R) to specimen width (W) ratios (R/W = 1/8 and 1/16), are calculated through finite element analysis. The finite element results are compared with predictions based on existing empirical models for SIF calculations. The effects of a change in R/W ratio on SIF of thru-thickness and thumb-nail cracks are also discussed. 34 refs.

Synthesis, Decay Properties, and Identification of Superheavy Nuclei Produced in 48Ca-induced Reactions

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Utyonkov, V. K.; Lobanov, Yu. V.; Abdullin, F. Sh.; Polyakov, A. N.; Sagaidak, R. N.; Shirokovsky, I. V.; Tsyganov, Yu. S.; Voinov, A. A.; Iliev, S.; Subbotin, V. G.; Sukhov, A. M.; Gulbekian, G. G.; Bogomolov, S. L.; Gikal, B. N.; Mezentsev, A. N.; Subotic, K.; Zagrebaev, V. I.; Itkis, M. G.; Moody, K. J.; Henderson, R. A.; Patin, J. B.; Shaughnessy, D. A.; Stoyer, M. A.; Stoyer, N. J.; Wilk, P. A.; Kenneally, J. M.; Landrum, J. H.; Wild, J. F.; Lougheed, R. W.

2007-10-01

Thirty-four new nuclides with Z = 104-116, 118 and N = 161-177 have been synthesized in the complete-fusion reactions of 238U, 237Np, 242,244Pu, 243Am, 245,248Cm, and 249Cf targets with 48Ca beams. The masses of evaporation residues were identified through measurements of the excitation functions of the xn-evaporation channels and from cross bombardments. The decay properties of the new nuclei agree with those of previously known heavy nuclei and with predictions from different theoretical models. A discussion of self-consistent interpretations of all observed decay chains originating from the parent isotopes 282,283112, 282113, 286-289114, 287,288115, 290-293116, and 294118 is presented. Decay energies and lifetimes of the neutron-rich superheavy nuclei as well as their production cross sections indicate a considerable increase in the stability of nuclei with the approach to the theoretically predicted nuclear shells with N = 184 and Z = 114.

Synthesis, Decay Properties, and Identification of Superheavy Nuclei Produced in 48CA-INDUCED Reactions

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Utyonkov, V. K.; Lobanov, Yu. V.; Abdullin, F. Sh.; Polyakov, A. N.; Sagaidak, R. N.; Shirokovsky, I. V.; Tsyganov, Yu. S.; Voinov, A. A.; Iliev, S.; Subbotin, V. G.; Sukhov, A. M.; Gulbekian, G. G.; Bogomolov, S. L.; Gikal, B. N.; Mezentsev, A. N.; Subotic, K.; Zagrebaev, V. I.; Itkis, M. G.; Moody, K. J.; Henderson, R. A.; Patin, J. B.; Shaughnessy, D. A.; Stoyer, M. A.; Stoyer, N. J.; Wilk, P. A.; Kenneally, J. M.; Landrum, J. H.; Wild, J. F.; Lougheed, R. W.

2008-04-01

Thirty-four new nuclides with Z = 104-116, 118 and N = 161-177 have been synthesized in the complete-fusion reactions of 238U, 237Np, 242,244Pu, 243Am, 245,248Cm, and 249Cf targets with 48Ca beams. The masses of evaporation residues were identified through measurements of the excitation functions of the xn-evaporation channels and from cross bombardments. The decay properties of the new nuclei agree with those of previously known heavy nuclei and with predictions from different theoretical models. A discussion of self-consistent interpretations of all observed decay chains originating from the parent isotopes 282,283112, 282113, 286-289114, 287,288115, 290-293116, and 294118 is presented. Decay energies and lifetimes of the neutron-rich superheavy nuclei as well as their production cross sections indicate a considerable increase in the stability of nuclei with the approach to the theoretically predicted nuclear shells with N = 184 and Z = 114.

40 CFR 1065.290 - PM gravimetric balance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false PM gravimetric balance. 1065.290 Section 1065.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments Pm Measurements § 1065.290 PM gravimetric...

40 CFR 1065.290 - PM gravimetric balance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 33 2014-07-01 2014-07-01 false PM gravimetric balance. 1065.290 Section 1065.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments Pm Measurements § 1065.290 PM gravimetric...

40 CFR 1065.290 - PM gravimetric balance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false PM gravimetric balance. 1065.290 Section 1065.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments Pm Measurements § 1065.290 PM gravimetric...

KSC-06pd2284

NASA Image and Video Library

2006-10-12

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, workers prepare to transfer the external tank from the checkout cell for attaching to its twin solid rocket boosters on the mobile launch platform in highbay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission no. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2286

NASA Image and Video Library

2006-10-12

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is transferred from the checkout cell for attaching to its twin solid rocket boosters on the mobile launch platform in highbay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission no. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2283

NASA Image and Video Library

2006-10-12

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, workers prepare to transfer the external tank from the checkout cell for attaching to its twin solid rocket boosters on the mobile launch platform in highbay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission no. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2288

NASA Image and Video Library

2006-10-12

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, the external tank is transferred from the checkout cell for attaching to its twin solid rocket boosters on the mobile launch platform in highbay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission no. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

KSC-06pd2285

NASA Image and Video Library

2006-10-12

KENNEDY SPACE CENTER, FLA. - Inside the Vehicle Assembly Building, workers prepare to transfer the external tank from the checkout cell for attaching to its twin solid rocket boosters on the mobile launch platform in highbay 3 for mission STS-116. The gigantic, rust-colored external tank is the largest element of the Space Shuttle system at 27.6-feet wide and 154-feet tall. STS-116 will be mission no. 20 to the International Space Station and construction flight 12A.1. The mission payload is the SPACEHAB module, the P5 integrated truss structure and other key components. Launch is scheduled for no earlier than Dec. 7. Photo credit: NASA/Jack Pfaller

Comparison of Medium Power Hall Effect Thruster Ion Acceleration for Krypton and Xenon Propellants

DTIC Science & Technology

2016-09-14

Concentration ppb 87 1000 Stable Isotopes 9 6 Odd Isotopes 2 1 Critical Pressure MPa 5.84 5.50 Critical Temperature K 290 209 Boiling Point (1 atm) K 161 120...The velocity profile in Fig. 6 shows the velocities slightly negative, nearest the anode (at approximately - 9 mm). This negative velocity near the...Krypton and Xenon Propellants 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6 . AUTHOR(S) William A. Hargus, Jr.; Gregory M. Azarnia; Michael R

Multiscale techniques for parabolic equations.

PubMed

Målqvist, Axel; Persson, Anna

2018-01-01

We use the local orthogonal decomposition technique introduced in Målqvist and Peterseim (Math Comput 83(290):2583-2603, 2014) to derive a generalized finite element method for linear and semilinear parabolic equations with spatial multiscale coefficients. We consider nonsmooth initial data and a backward Euler scheme for the temporal discretization. Optimal order convergence rate, depending only on the contrast, but not on the variations of the coefficients, is proven in the [Formula: see text]-norm. We present numerical examples, which confirm our theoretical findings.

Risk factors for stillbirth and dystocia in Japanese Black cattle.

PubMed

Uematsu, Mizuho; Sasaki, Yosuke; Kitahara, Go; Sameshima, Hiroshi; Osawa, Takeshi

2013-10-01

Stillbirth and dystocia are major factors reducing the productivity of beef cattle. The objective of this study was to determine the effect of season, parity and gestation length on the rates of stillbirth and dystocia in Japanese Black cattle. Calving records were obtained from 905 farms in Miyazaki Prefecture, Japan. Data were collected from 41,116 calvings in 15,378 (14.42% primiparous). There were 1013 stillbirths (2.46%) and 3514 dystocias (8.55%). The stillbirth rate in winter (December to February) (3.18%) was higher (odds ratio (OR) [95% confidence interval]: 1.008 [1.004-1.012]) than that in summer (June to August). Similarly, the dystocia rates in winter (OR: 1.011 [1.004-1.019]) and spring (March to May) (OR: 1.020 [1.013-1.027]) were significantly higher than in summer. For primiparous cows, the rates of stillbirth (OR: 1.010 [1.004-1.015]) and dystocia (OR: 1.053 [1.042-1.064]) were higher than in cows with fifth parity (reference parity). Stillbirth rates were higher in cows at ≥ 301 days of pregnancy (OR: 1.049 [1.035-1.062]) and those at ≤ 270 days of pregnancy (OR: 2.072 [2.044-2.101]) than those at between 281 and 290 days of pregnancy. Likewise, dystocia rates were higher in cows at ≥ 301 days of pregnancy (OR: 1.033 [1.008-1.059]) and those at ≤ 270 days of pregnancy (OR: 1.124 [1.095-1.154]) than those at between 281 and 290 days of pregnancy. Winter, primiparity, and long and short gestation lengths were risk factors for stillbirth and dystocia in this cohort of Japanese Black cattle. Copyright © 2013 Elsevier Ltd. All rights reserved.

40 CFR 421.290 - Applicability: Description of the secondary tin subcategory.

Code of Federal Regulations, 2012 CFR

2012-07-01

... secondary tin subcategory. 421.290 Section 421.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tin Subcategory § 421.290 Applicability: Description of the secondary tin subcategory. The provisions of this subpart are applicable to discharges resulting from the production of tin at secondary tin...

40 CFR 421.290 - Applicability: Description of the secondary tin subcategory.

Code of Federal Regulations, 2010 CFR

2010-07-01

... secondary tin subcategory. 421.290 Section 421.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tin Subcategory § 421.290 Applicability: Description of the secondary tin subcategory. The provisions of this subpart are applicable to discharges resulting from the production of tin at secondary tin...

40 CFR 421.290 - Applicability: Description of the secondary tin subcategory.

Code of Federal Regulations, 2013 CFR

2013-07-01

... secondary tin subcategory. 421.290 Section 421.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tin Subcategory § 421.290 Applicability: Description of the secondary tin subcategory. The provisions of this subpart are applicable to discharges resulting from the production of tin at secondary tin...

40 CFR 421.290 - Applicability: Description of the secondary tin subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... secondary tin subcategory. 421.290 Section 421.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tin Subcategory § 421.290 Applicability: Description of the secondary tin subcategory. The provisions of this subpart are applicable to discharges resulting from the production of tin at secondary tin...

40 CFR 421.290 - Applicability: Description of the secondary tin subcategory.

Code of Federal Regulations, 2014 CFR

2014-07-01

... secondary tin subcategory. 421.290 Section 421.290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tin Subcategory § 421.290 Applicability: Description of the secondary tin subcategory. The provisions of this subpart are applicable to discharges resulting from the production of tin at secondary tin...

Development of freight policy analysis tool for northeastern Illinois and the United States.

DOT National Transportation Integrated Search

2010-10-01

Freight transportation is a vital element in the economic prosperity of any country. According to the : nationwide commodity flow survey, over 12 billion tons of goods, valued at more than $11.6 trillion, were moved in : America in the year 2007(Bure...

32 CFR 290.8 - Fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Fees. 290.8 Section 290.8 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM § 290.8 Fees. (a) Fees...

32 CFR 290.8 - Fees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Fees. 290.8 Section 290.8 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM § 290.8 Fees. (a) Fees...

33 CFR 105.290 - Additional requirements-cruise ship terminals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES Facility Security Requirements § 105.290 Additional requirements—cruise ship terminals...

18 CFR 290.102 - Information gathering and filing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Information gathering and filing. 290.102 Section 290.102 Conservation of Power and Water Resources FEDERAL ENERGY... POLICIES ACT OF 1978 Coverage, Compliance and Definitions § 290.102 Information gathering and filing. All...

18 CFR 290.102 - Information gathering and filing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Information gathering and filing. 290.102 Section 290.102 Conservation of Power and Water Resources FEDERAL ENERGY... POLICIES ACT OF 1978 Coverage, Compliance and Definitions § 290.102 Information gathering and filing. All...

46 CFR 148.290 - Peat moss.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 5 2011-10-01 2011-10-01 false Peat moss. 148.290 Section 148.290 Shipping COAST GUARD... SPECIAL HANDLING Special Requirements for Certain Materials § 148.290 Peat moss. (a) Before shipment, peat... handling or coming into contact with peat moss must wear gloves, a dust mask, and goggles. ...

27 CFR 28.290 - Receipt in foreign trade zone.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Receipt in foreign trade zone. 28.290 Section 28.290 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... in Foreign-Trade Zone § 28.290 Receipt in foreign trade zone. On receipt at the zone, the shipment...

27 CFR 28.290 - Receipt in foreign trade zone.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Receipt in foreign trade zone. 28.290 Section 28.290 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... in Foreign-Trade Zone § 28.290 Receipt in foreign trade zone. On receipt at the zone, the shipment...

27 CFR 28.290 - Receipt in foreign trade zone.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Receipt in foreign trade zone. 28.290 Section 28.290 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... in Foreign-Trade Zone § 28.290 Receipt in foreign trade zone. On receipt at the zone, the shipment...

27 CFR 28.290 - Receipt in foreign trade zone.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Receipt in foreign trade zone. 28.290 Section 28.290 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... in Foreign-Trade Zone § 28.290 Receipt in foreign trade zone. On receipt at the zone, the shipment...

12 CFR 150.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2014 CFR

2014-01-01

... investment or distribution? 150.290 Section 150.290 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF FEDERAL SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 150.290 What must I do with fiduciary funds awaiting investment or...

12 CFR 550.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2014 CFR

2014-01-01

... investment or distribution? 550.290 Section 550.290 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 550.290 What must I do with fiduciary funds awaiting investment or...

12 CFR 550.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2012 CFR

2012-01-01

... investment or distribution? 550.290 Section 550.290 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 550.290 What must I do with fiduciary funds awaiting investment or...

12 CFR 550.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2011 CFR

2011-01-01

... investment or distribution? 550.290 Section 550.290 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 550.290 What must I do with fiduciary funds awaiting investment or...

12 CFR 150.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2012 CFR

2012-01-01

... investment or distribution? 150.290 Section 150.290 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF FEDERAL SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 150.290 What must I do with fiduciary funds awaiting investment or...

12 CFR 550.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2013 CFR

2013-01-01

... investment or distribution? 550.290 Section 550.290 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 550.290 What must I do with fiduciary funds awaiting investment or...

12 CFR 150.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2013 CFR

2013-01-01

... investment or distribution? 150.290 Section 150.290 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF FEDERAL SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds Awaiting Investment Or Distribution § 150.290 What must I do with fiduciary funds awaiting investment or...

32 CFR 290.4 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 290.4 Section 290.4 National Defense... PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM § 290.4 Policy. Agency policy and procedures are those cited in DoD 5400.7-R. In addition, DCAA will: (a) Promote public trust...

21 CFR 290.6 - Spanish-language version of required warning.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Spanish-language version of required warning. 290.6 Section 290.6 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.6 Spanish-language version of required...

18 CFR 290.103 - Time of filing and reporting period.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Time of filing and reporting period. 290.103 Section 290.103 Conservation of Power and Water Resources FEDERAL ENERGY... POLICIES ACT OF 1978 Coverage, Compliance and Definitions § 290.103 Time of filing and reporting period...

18 CFR 290.103 - Time of filing and reporting period.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Time of filing and reporting period. 290.103 Section 290.103 Conservation of Power and Water Resources FEDERAL ENERGY... POLICIES ACT OF 1978 Coverage, Compliance and Definitions § 290.103 Time of filing and reporting period...

33 CFR 334.290 - Elizabeth River, Southern Branch, Va., naval restricted areas.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Va., naval restricted areas. 334.290 Section 334.290 Navigation and Navigable Waters CORPS OF....290 Elizabeth River, Southern Branch, Va., naval restricted areas. (a) The areas—(1) St. Helena Annex Area. Beginning at a point at St. Helena Annex of the Norfolk Naval Shipyard, on the eastern shore of...

33 CFR 334.290 - Elizabeth River, Southern Branch, Va., naval restricted areas.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Va., naval restricted areas. 334.290 Section 334.290 Navigation and Navigable Waters CORPS OF....290 Elizabeth River, Southern Branch, Va., naval restricted areas. (a) The areas—(1) St. Helena Annex Area. Beginning at a point at St. Helena Annex of the Norfolk Naval Shipyard, on the eastern shore of...

32 CFR 219.116 - General requirements for informed consent.

Code of Federal Regulations, 2012 CFR

2012-07-01

... will not adversely affect the rights and welfare of the subjects; (3) The research could not... subject in research covered by this policy unless the investigator has obtained the legally effective... investigator, the sponsor, the institution or its agents from liability for negligence. (a) Basic elements of...

14 CFR § 1230.116 - General requirements for informed consent.

Code of Federal Regulations, 2014 CFR

2014-01-01

... will not adversely affect the rights and welfare of the subjects; (3) The research could not... research covered by this policy unless the investigator has obtained the legally effective informed consent..., the institution or its agents from liability for negligence. (a) Basic elements of informed consent...

U. S. Naval Forces, Vietnam Monthly Historical Summary for February 1970

DTIC Science & Technology

1970-04-09

Search Turn Campaign .................... 28 Riverine Strike Grouo ..... .............. . . . . . . 33 Breezy Cove. ......... . . . . . . . . . 34...116 MVAYAL ADIVYSORY GROUP SUMRY . .. .. .. .. .. .. . .. 119 Vietnamese Mdarine Corps .. .. .. .. .. .. .. ... . 137 VNMC Operations Control ...helicopter (Dustoff) and artillery assistance wias requested. At 1 9377, -an Air Force rors-ard Air Controller arrived on station and air elements

Testing the antidepressant properties of the peptide ARA290 in a human neuropsychological model of drug action.

PubMed

Cerit, Hilâl; Veer, Ilya M; Dahan, Albert; Niesters, Marieke; Harmer, Catherine J; Miskowiak, Kamilla W; Rombouts, Serge A R B; Van der Does, Willem

2015-12-01

Studies on the neural effects of Erythropoietin (EPO) indicate that EPO may have antidepressant effects. Due to its hematopoietic effects, EPO may cause serious side-effects with repeated administration if patients are not monitored extensively. ARA290 is an EPO-analog peptide without such hematopoietic side-effects but may have neurotrophic and antidepressant effects. The aim of this study was to investigate the possible antidepressant effects of ARA290 in a neuropsychological model of drug action. Healthy participants (N=36) received ARA290 (2mg) or placebo in a double-blind, randomized, parallel-group design. Neural and cognitive effects were assessed one week after administration. Primary outcome measures were the neural processing of fearful vs happy faces and the behavioral recognition of emotional facial expressions. ARA290-treated individuals displayed lower neural responses to happy faces in the fusiform gyrus. ARA290 tended to lower the recognition of happy and disgust facial expressions. Although ARA290 was not associated with a better memory for positive words, it was associated with faster categorization of positive vs negative words. Finally, ARA290 increased attention towards positive emotional pictures. No effects were observed on mood and affective symptoms. ARA290 may modulate some aspects of emotional processing, however, the direction and the strength of its effects do not unequivocally support an antidepressant-like profile for ARA290. Future studies may investigate the effects of different timing and dose. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

25 CFR 290.21 - May an Indian tribe appeal the ABO's decision?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true May an Indian tribe appeal the ABO's decision? 290.21 Section 290.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES TRIBAL REVENUE ALLOCATION PLANS § 290.21 May an Indian tribe appeal the ABO's decision? Yes, you may appeal the...

25 CFR 290.21 - May an Indian tribe appeal the ABO's decision?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false May an Indian tribe appeal the ABO's decision? 290.21 Section 290.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES TRIBAL REVENUE ALLOCATION PLANS § 290.21 May an Indian tribe appeal the ABO's decision? Yes, you may appeal the...

32 CFR Appendix C to Part 290 - For Official Use Only

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false For Official Use Only C Appendix C to Part 290.... 290, App. C Appendix C to Part 290—For Official Use Only (a) General. Information that has not been... 22161. (c) Markings. (1) Location of Markings. (i) An unclassified document containing FOUO information...

Antisense Oligonucleotide (AON)-based Therapy for Leber Congenital Amaurosis Caused by a Frequent Mutation in CEP290

PubMed Central

Collin, Rob WJ; den Hollander, Anneke I; van der Velde-Visser, Saskia D; Bennicelli, Jeannette; Bennett, Jean; Cremers, Frans PM

2012-01-01

Leber congenital amaurosis (LCA) is the most severe form of inherited retinal degeneration, with an onset in the first year of life. The most frequent mutation that causes LCA, present in at least 10% of individuals with LCA from North-American and Northern-European descent, is an intronic mutation in CEP290 that results in the inclusion of an aberrant exon in the CEP290 mRNA. Here, we describe a genetic therapy approach that is based on antisense oligonucleotides (AONs), small RNA molecules that are able to redirect normal splicing of aberrantly processed pre-mRNA. Immortalized lymphoblastoid cells of individuals with LCA homozygously carrying the intronic CEP290 mutation were transfected with several AONs that target the aberrant exon that is incorporated in the mutant CEP290 mRNA. Subsequent RNA isolation and reverse transcription-PCR analysis revealed that a number of AONs were capable of almost fully redirecting normal CEP290 splicing, in a dose-dependent manner. Other AONs however, displayed no effect on CEP290 splicing at all, indicating that the rescue of aberrant CEP290 splicing shows a high degree of sequence specificity. Together, our data show that AON-based therapy is a promising therapeutic approach for CEP290-associated LCA that warrants future research in animal models to develop a cure for this blinding disease. PMID:23343883

25 CFR 290.15 - Must the Indian tribe establish trust accounts with financial institutions for minors and legal...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Must the Indian tribe establish trust accounts with financial institutions for minors and legal incompetents? 290.15 Section 290.15 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ECONOMIC ENTERPRISES TRIBAL REVENUE ALLOCATION PLANS § 290.15 Must the Indian tribe establish trust accounts with...

Concentrations of choline-containing compounds and betaine in common foods.

PubMed

Zeisel, Steven H; Mar, Mei-Heng; Howe, Juliette C; Holden, Joanne M

2003-05-01

Choline is important for normal membrane function, acetylcholine synthesis and methyl group metabolism; the choline requirement for humans is 550 mg/d for men (Adequate Intake). Betaine, a choline derivative, is important because of its role in the donation of methyl groups to homocysteine to form methionine. In tissues and foods, there are multiple choline compounds that contribute to total choline concentration (choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin). In this study, we collected representative food samples and analyzed the choline concentration of 145 common foods using liquid chromatography-mass spectrometry. Foods with the highest total choline concentration (mg/100 g) were: beef liver (418), chicken liver (290), eggs (251), wheat germ (152), bacon (125), dried soybeans (116) and pork (103). The foods with the highest betaine concentration (mg/100 g) were: wheat bran (1339), wheat germ (1241), spinach (645), pretzels (237), shrimp (218) and wheat bread (201). A number of epidemiologic studies have examined the relationship between dietary folic acid and cancer or heart disease. It may be helpful to also consider choline intake as a confounding factor because folate and choline methyl donation can be interchangeable.

Posttraumatic stress disorder following ethnoreligious conflict in Jos, Nigeria.

PubMed

Obilom, Rose E; Thacher, Tom D

2008-08-01

In September 2001, ethnoreligious rioting occurred in Jos, Nigeria. Using a multistage cluster sampling technique, 290 respondents were recruited in Jos 7 to 9 months after the riot. Data were collected regarding demographics, exposure to traumatic events, and psychological symptoms. Resting pulse and blood pressure were recorded. A total of 145 (52.5%) witnessed or were victims of personal attacks, 165 (59.6%) lost their possessions, 56 (20.7%) had their homes burned, 44 (16.2%) witnessed relatives' deaths, and 8 (2.9%) were robbed. A total of 252 (89.7%) of the respondents met reexperiencing criteria, 138 (49.1%) met avoidance criteria, and 236 (84.0%) met arousal criteria for posttraumatic stress disorder (PTSD). A total of 116 (41%, 95% confidence interval [CI] = 36% to 47%) met all three categories for PTSD. Only personal attacks (adjusted odds ratio = 2.8, 95% CI = 1.7 to 4.7) and a heart rate of 90 beats/min or more (adjusted odds ratio = 2.8, 95% CI = 1.4 to 5.8) were significantly related to PTSD in a multivariate model.

ICD-10 procedure codes produce transition challenges.

PubMed

Boyd, Andrew D; Li, Jianrong 'John'; Kenost, Colleen; Zaim, Samir Rachid; Krive, Jacob; Mittal, Manish; Satava, Richard A; Burton, Michael; Smith, Jacob; Lussier, Yves A

2018-01-01

The transition of procedure coding from ICD-9-CM-Vol-3 to ICD-10-PCS has generated problems for the medical community at large resulting from the lack of clarity required to integrate two non-congruent coding systems. We hypothesized that quantifying these issues with network topology analyses offers a better understanding of the issues, and therefore we developed solutions (online tools) to empower hospital administrators and researchers to address these challenges. Five topologies were identified: "identity"(I), "class-to-subclass"(C2S), "subclass-toclass"(S2C), "convoluted(C)", and "no mapping"(NM). The procedure codes in the 2010 Illinois Medicaid dataset (3,290 patients, 116 institutions) were categorized as C=55%, C2S=40%, I=3%, NM=2%, and S2C=1%. Majority of the problematic and ambiguous mappings (convoluted) pertained to operations in ophthalmology cardiology, urology, gyneco-obstetrics, and dermatology. Finally, the algorithms were expanded into a user-friendly tool to identify problematic topologies and specify lists of procedural codes utilized by medical professionals and researchers for mitigating error-prone translations, simplifying research, and improving quality.http://www.lussiergroup.org/transition-to-ICD10PCS.

7 CFR 205.290 - Temporary variances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Temporary variances. 205.290 Section 205.290 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT...

STS116-S-001

NASA Image and Video Library

2006-07-01

STS116-S-001 (July 2006) --- The STS-116 patch design signifies the continuing assembly of the International Space Station (ISS). The primary mission objective is to deliver and install the P5 truss element. The P5 installation will be conducted during the first of three planned spacewalks, and will involve use of both the shuttle and station robotic arms. The remainder of the mission will include a major reconfiguration and activation of the ISS electrical and thermal control systems, as well as delivery of Zvezda Service Module debris panels, which will increase ISS protection from potential impacts of micro-meteorites and orbital debris. In addition, a single expedition crewmember will launch on STS-116 to remain onboard the station, replacing an expedition crew member that will fly home with the shuttle crew. The crew patch depicts the space shuttle rising above the Earth and ISS. The United States and Swedish flags trail the orbiter, depicting the international composition of the STS-116 crew. The seven stars of the constellation Ursa Major are used to provide direction to the North Star, which is superimposed over the installation location of the P5 truss on ISS. The NASA insignia design for space shuttle flights is reserved for use by the astronauts and for other official use as the NASA Administrator may authorize. Public availability has been approved only in the forms of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, the change will be publicly announced. Photo credit: NASA

Mechanism of estrogen activation of c-myc oncogene expression.

PubMed

Dubik, D; Shiu, R P

1992-08-01

The estrogen receptor complex is a known trans-acting factor that regulates transcription of specific genes through an interaction with a specific estrogen-responsive cis-acting element (ERE). In previous studies we have shown that in estrogen-responsive human breast cancer cells estrogen rapidly activates c-myc expression. This activated expression occurs through enhanced transcription and does not require the synthesis of new protein intermediates; therefore, an ERE is present in the human c-myc gene regulatory region. To localize the ERE, constructs containing varying lengths of the c-myc 5'-flanking region ranging from -2327 to +25 (relative to the P1 promoter) placed adjacent to the chloramphenicol acetyl transferase reporter gene (CAT) were prepared. They were used in transient transfection studies in MCF-7 and HeLa cells co-transfected with an estrogen receptor expression vector. These studies reveal that all constructs containing the P2 promoter region exhibited estrogen-regulated CAT expression and that a 116-bp region upstream and encompassing the P2 TATA box is necessary for this activity. Analysis of this 116-bp region failed to identify a cis-acting element with sequences resembling the consensus ERE; however, co-transfection studies with mutant estrogen receptor expression vectors showed that the DNA-binding domain of the receptor is essential for estrogen-regulated CAT gene expression. We have also observed that anti-estrogen receptor complexes can weakly trans-activate from this 116-bp region but fail to do so from the ERE-containing ApoVLDLII-CAT construct. To explain these results we propose a new mechanism of estrogen trans-activation in the c-myc gene promoter.

Further Insights into the Allan-Herndon-Dudley Syndrome: Clinical and Functional Characterization of a Novel MCT8 Mutation.

PubMed

Armour, Christine M; Kersseboom, Simone; Yoon, Grace; Visser, Theo J

2015-01-01

Mutations in the thyroid hormone (TH) transporter MCT8 have been identified as the cause for Allan-Herndon-Dudley Syndrome (AHDS), characterized by severe psychomotor retardation and altered TH serum levels. Here we report a novel MCT8 mutation identified in 4 generations of one family, and its functional characterization. Proband and family members were screened for 60 genes involved in X-linked cognitive impairment and the MCT8 mutation was confirmed. Functional consequences of MCT8 mutations were studied by analysis of [125I]TH transport in fibroblasts and transiently transfected JEG3 and COS1 cells, and by subcellular localization of the transporter. The proband and a male cousin demonstrated clinical findings characteristic of AHDS. Serum analysis showed high T3, low rT3, and normal T4 and TSH levels in the proband. A MCT8 mutation (c.869C>T; p.S290F) was identified in the proband, his cousin, and several female carriers. Functional analysis of the S290F mutant showed decreased TH transport, metabolism and protein expression in the three cell types, whereas the S290A mutation had no effect. Interestingly, both uptake and efflux of T3 and T4 was impaired in fibroblasts of the proband, compared to his healthy brother. However, no effect of the S290F mutation was observed on TH efflux from COS1 and JEG3 cells. Immunocytochemistry showed plasma membrane localization of wild-type MCT8 and the S290A and S290F mutants in JEG3 cells. We describe a novel MCT8 mutation (S290F) in 4 generations of a family with Allan-Herndon-Dudley Syndrome. Functional analysis demonstrates loss-of-function of the MCT8 transporter. Furthermore, our results indicate that the function of the S290F mutant is dependent on cell context. Comparison of the S290F and S290A mutants indicates that it is not the loss of Ser but its substitution with Phe, which leads to S290F dysfunction.

Further Insights into the Allan-Herndon-Dudley Syndrome: Clinical and Functional Characterization of a Novel MCT8 Mutation

PubMed Central

Yoon, Grace; Visser, Theo J.

2015-01-01

Background Mutations in the thyroid hormone (TH) transporter MCT8 have been identified as the cause for Allan-Herndon-Dudley Syndrome (AHDS), characterized by severe psychomotor retardation and altered TH serum levels. Here we report a novel MCT8 mutation identified in 4 generations of one family, and its functional characterization. Methods Proband and family members were screened for 60 genes involved in X-linked cognitive impairment and the MCT8 mutation was confirmed. Functional consequences of MCT8 mutations were studied by analysis of [125I]TH transport in fibroblasts and transiently transfected JEG3 and COS1 cells, and by subcellular localization of the transporter. Results The proband and a male cousin demonstrated clinical findings characteristic of AHDS. Serum analysis showed high T3, low rT3, and normal T4 and TSH levels in the proband. A MCT8 mutation (c.869C>T; p.S290F) was identified in the proband, his cousin, and several female carriers. Functional analysis of the S290F mutant showed decreased TH transport, metabolism and protein expression in the three cell types, whereas the S290A mutation had no effect. Interestingly, both uptake and efflux of T3 and T4 was impaired in fibroblasts of the proband, compared to his healthy brother. However, no effect of the S290F mutation was observed on TH efflux from COS1 and JEG3 cells. Immunocytochemistry showed plasma membrane localization of wild-type MCT8 and the S290A and S290F mutants in JEG3 cells. Conclusions We describe a novel MCT8 mutation (S290F) in 4 generations of a family with Allan-Herndon-Dudley Syndrome. Functional analysis demonstrates loss-of-function of the MCT8 transporter. Furthermore, our results indicate that the function of the S290F mutant is dependent on cell context. Comparison of the S290F and S290A mutants indicates that it is not the loss of Ser but its substitution with Phe, which leads to S290F dysfunction. PMID:26426690

Chemical Dissolution of Simulant FCA Cladding and Plates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel, G.; Pierce, R.; O'Rourke, P.

The Savannah River Site (SRS) has received some fast critical assembly (FCA) fuel from the Japan Atomic Energy Agency (JAEA) for disposition. Among the JAEA FCA fuel are approximately 7090 rectangular Stainless Steel clad fuel elements. Each element has an internal Pu-10.6Al alloy metal wafer. The thickness of each element is either 1/16 inch or 1/32 inch. The dimensions of each element ranges from 2 inches x 1 inch to 2 inches x 4 inches. This report discusses the potential chemical dissolution of the FCA clad material or stainless steel. This technology uses nitric acid-potassium fluoride (HNO 3-KF) flowsheets ofmore » H-Canyon to dissolve the FCA elements from a rack of materials. Historically, dissolution flowsheets have aimed to maximize Pu dissolution rates while minimizing stainless steel dissolution (corrosion) rates. Because the FCA cladding is made of stainless steel, this work sought to accelerate stainless steel dissolution.« less

25 CFR 290.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... or programs, such as payments made for social welfare, medical assistance, education, housing or... 25 Indians 1 2011-04-01 2011-04-01 false Definitions. 290.2 Section 290.2 Indians BUREAU OF INDIAN... Definitions. Appropriate Bureau official (ABO) means the Bureau official with delegated authority to approve...

45 CFR 156.290 - Non-renewal and decertification of QHPs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Section 156.290 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.290 Non-renewal and...

45 CFR 156.290 - Non-renewal and decertification of QHPs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Section 156.290 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.290 Non-renewal and...

45 CFR 156.290 - Non-renewal and decertification of QHPs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 156.290 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE ISSUER STANDARDS UNDER THE AFFORDABLE CARE ACT, INCLUDING STANDARDS RELATED TO EXCHANGES Qualified Health Plan Minimum Certification Standards § 156.290 Non-renewal and...

15 CFR 290.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Purpose. 290.1 Section 290.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF...

15 CFR 290.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Purpose. 290.1 Section 290.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF...

15 CFR 290.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Purpose. 290.1 Section 290.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF...

15 CFR 290.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Purpose. 290.1 Section 290.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF...

15 CFR 290.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Purpose. 290.1 Section 290.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF...

Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice.

PubMed

Devalliere, Julie; Dooley, Kevin; Hu, Yong; Kelangi, Sarah S; Uygun, Basak E; Yarmush, Martin L

2017-10-01

Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth factor (KGF) and the cellular protective peptide ARA290 into a protein polymer suspension with the purpose of increasing their proteolytic resistance, thus their activity in vivo. KGF and ARA290 were fused with elastin-like peptide (ELP), a protein polymer derived from tropoelastin, that confers the ability to separate into a colloidal suspension of liquid-like coacervates. ELP fusion did not diminish peptides activities as demonstrated by ability of KGF-ELP to accelerate keratinocyte proliferation and migration, and ARA290-ELP to protect cells from apoptosis. We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model. In this model, ARA290-ELP was found to accelerate healing, notably by increasing angiogenesis in the wound bed. We further showed that co-delivery of ARA290 and KGF, with the 1:4 KGF-ELP to ARA290-ELP ratio, was the most effective wound treatment with the fastest healing rate, the thicker granulation tissue and regenerated epidermis after 28 days. Overall, this study shows that ARA290-ELP and KGF-ELP constitute promising new therapeutics for treatment of chronic wounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

Antisense Oligonucleotide-Based Splicing Correction in Individuals with Leber Congenital Amaurosis due to Compound Heterozygosity for the c.2991+1655A>G Mutation in CEP290.

PubMed

Duijkers, Lonneke; van den Born, L Ingeborgh; Neidhardt, John; Bax, Nathalie M; Pierrache, Laurence H M; Klevering, B Jeroen; Collin, Rob W J; Garanto, Alejandro

2018-03-07

Leber congenital amaurosis (LCA) is a rare inherited retinal disorder affecting approximately 1:50,000 people worldwide. So far, mutations in 25 genes have been associated with LCA, with CEP290 (encoding the Centrosomal protein of 290 kDa) being the most frequently mutated gene. The most recurrent LCA-causing CEP290 mutation, c.2991+1655A>G, causes the insertion of a pseudoexon into a variable proportion of CEP290 transcripts. We previously demonstrated that antisense oligonucleotides (AONs) have a high therapeutic potential for patients homozygously harbouring this mutation, although to date, it is unclear whether rescuing one single allele is enough to restore CEP290 function. Here, we assessed the AON efficacy at RNA, protein and cellular levels in samples that are compound heterozygous for this mutation, together with a protein-truncating mutation in CEP290 . We demonstrate that AONs can efficiently restore splicing and increase protein levels. However, due to a high variability in ciliation among the patient-derived cell lines, the efficacy of the AONs was more difficult to assess at the cellular level. This observation points towards the importance of the severity of the second allele and possibly other genetic variants present in each individual. Overall, AONs seem to be a promising tool to treat CEP290 -associated LCA, not only in homozygous but also in compound heterozygous carriers of the c.2991+1655A>G variant.

Transformation of a Finite-Element Model of a Piezoelectric Spherical Shell Transducer from a Nodal to a Spherical Harmonic Function Representation

DTIC Science & Technology

1990-06-01

J) :(270, )..pTod( 301,j)s(331,j)- pcod (302.j) s(271,j)-prod(303,J)s(332,j ):prod(304,J) s(272,J) prod(305,i) s(333,j) prod(306,j) s(273,jJ.’ptod(307...j).prodf 335,J) sf348, j)-prod( 336.1) 9(288,j)-prod(337,J) of 349, j)- pcod ( 338,J) s(209, j)-prod(339,J) of 350,j)-prod( 340,J) s(290,jJ.. pCod (341,J

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

21 CFR 173.290 - Trichloroethylene.

Code of Federal Regulations, 2014 CFR

2014-04-01

... trichloroethylene resulting from its use as a solvent in the manufacture of foods as follows: Decaffeinated ground... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Trichloroethylene. 173.290 Section 173.290 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SECONDARY...

24 CFR 290.30 - General.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

24 CFR 290.30 - General.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

24 CFR 290.30 - General.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

24 CFR 290.30 - General.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

41 CFR 102-118.290 - Must every electronic and paper transportation bill undergo a prepayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... and paper transportation bill undergo a prepayment audit? 102-118.290 Section 102-118.290 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Confidentiality of cave location information. 290.4 Section 290.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... organizations assisting the land management agencies with cave management activities. To request confidential...

15 CFR 290.9 - Intellectual property rights.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR...

15 CFR 290.9 - Intellectual property rights.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR...

15 CFR 290.9 - Intellectual property rights.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR...

15 CFR 290.9 - Intellectual property rights.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR...

15 CFR 290.9 - Intellectual property rights.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Intellectual property rights. 290.9 Section 290.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR...

Computer Resources Handbook for Flight Critical Systems.

DTIC Science & Technology

1985-01-01

8183 UNCLASSIFIED F /G 1 /3 NLllEEEEEEEEEEEE Illll lflflflflfl Illlfll..lflll EIEEIhEEIIIIII llElfllfllflfllfll .flflflflflflflflflflflll llEEEEEEllEII...Requiring Simulation .... ............. ... 114 6-4 Typical Transition Elements of Care III. ...... ............ 116 D- 1 F -16 Digital Flight Control...following forms: 1 . By reference to MIL- F -9490(for flight control systems); 2. By reference, with tailoring if required, to a Federal Aviation Regulation

21 CFR 173.290 - Trichloroethylene.

Code of Federal Regulations, 2013 CFR

2013-04-01

... established for residues of trichloroethylene resulting from its use as a solvent in the manufacture of foods... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Trichloroethylene. 173.290 Section 173.290 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

21 CFR 173.290 - Trichloroethylene.

Code of Federal Regulations, 2012 CFR

2012-04-01

... established for residues of trichloroethylene resulting from its use as a solvent in the manufacture of foods... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Trichloroethylene. 173.290 Section 173.290 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

33 CFR 105.290 - Additional requirements-cruise ship terminals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

33 CFR 105.290 - Additional requirements-cruise ship terminals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

33 CFR 105.290 - Additional requirements-cruise ship terminals.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

33 CFR 105.290 - Additional requirements-cruise ship terminals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Additional requirements—cruise ship terminals. At all MARSEC Levels, in coordination with a vessel moored at...

29 CFR 1952.290 - Description of the plan as initially approved.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 1952.290 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... § 1952.290 Description of the plan as initially approved. (a) The Nevada Occupational Safety and Health program will be administered and enforced by the Department of Occupational Safety and Health of the...

21 CFR 290.10 - Definition of emergency situation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Definition of emergency situation. 290.10 Section...) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.10 Definition of emergency situation. For the... Controlled Substances Act, the term emergency situation means those situations in which the prescribing...

18 CFR 290.101 - Applicability and exemptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... total sales of electric energy by such utility for purposes other than resale exceed 500 million... by name in Appendix A to this part; or (2) That has total sales of electric energy for purposes other... exemptions. 290.101 Section 290.101 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY...

18 CFR 290.101 - Applicability and exemptions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... total sales of electric energy by such utility for purposes other than resale exceed 500 million... by name in Appendix A to this part; or (2) That has total sales of electric energy for purposes other... exemptions. 290.101 Section 290.101 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kang, Kyungsu; Lee, Kyung-Mi; Yoo, Ji-Hye

Graphical abstract: Schematic diagram of the possible molecular mechanism underlying the inhibition of the Wnt/{beta}-catenin signaling pathway and the induction of G0/G1-phase arrest by gomisins J and N, derived from the fruits of S. chinensis, in HCT116 human colon cancer cells. Highlights: Black-Right-Pointing-Pointer Gomisins J and N inhibited Wnt/{beta}-catenin signaling pathway in HCT116 cells. Black-Right-Pointing-Pointer Gomisins J and N disrupted the binding of {beta}-catenin to specific DNA sequences, TBE. Black-Right-Pointing-Pointer Gomisins J and N inhibited the HCT116 cell proliferation through G0/G1 phase arrest. Black-Right-Pointing-Pointer Gomisins J and N inhibited the expression of Cyc D1, a Wnt/{beta}-catenin target gene. -- Abstract:more » Here, we report that gomisin J and gomisin N, dibenzocyclooctadiene type lignans isolated from Schisandra chinensis, inhibit Wnt/{beta}-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/{beta}-catenin signaling by disrupting the interaction between {beta}-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the {beta}-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/{beta}-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/{beta}-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers.« less

Antenatal education and postnatal support strategies for improving rates of exclusive breast feeding: randomised controlled trial.

PubMed

Su, Lin-Lin; Chong, Yap-Seng; Chan, Yiong-Huak; Chan, Yah-Shih; Fok, Doris; Tun, Kay-Thwe; Ng, Faith S P; Rauff, Mary

2007-09-22

To investigate whether antenatal breast feeding education alone or postnatal lactation support alone improves rates of exclusive breast feeding compared with routine hospital care. Randomised controlled trial. A tertiary hospital in Singapore. 450 women with uncomplicated pregnancies. Primary outcomes were rates of exclusive breast feeding at discharge from hospital and two weeks, six weeks, three months, and six months after delivery. Secondary outcomes were rates of any breast feeding. Compared with women who received routine care, women in the postnatal support group were more likely to breastfeed exclusively at two weeks (relative risk 1.82, 95% confidence interval 1.14 to 2.90), six weeks (1.85, 1.11 to 3.09), three months (1.87, 1.03 to 3.41), and six months (2.12, 1.03 to 4.37) postnatally. Women receiving antenatal education were more likely to breast feed exclusively at six weeks (1.73, 1.04 to 2.90), three months (1.92, 1.07 to 3.48), and six months (2.16, 1.05 to 4.43) postnatally. The numbers needed to treat to achieve one woman exclusively breast feeding at six months were 11 (6 to 80) for postnatal support and 10 (6 to 60) for antenatal education. Women who received postnatal support were more likely to exclusively or predominantly breast feed two weeks after delivery compared with women who received antenatal education (1.53, 1.01 to 2.31). The rate of any breastfeeding six weeks after delivery was also higher in the postnatal support group compared with women who received routine care (1.16, 1.02 to 1.31). Antenatal breast feeding education and postnatal lactation support, as single interventions based in hospital both significantly improve rates of exclusive breast feeding up to six months after delivery. Postnatal support was marginally more effective than antenatal education. Clinical Trials NCT00270920 [ClinicalTrials.gov].

Cost-effectiveness analysis of the bivalent compared with the quadrivalent human papillomavirus vaccines in Taiwan.

PubMed

Demarteau, Nadia; Tang, Chao-Hsiun; Chen, Hui-Chi; Chen, Chien-Jen; Van Kriekinge, Georges

2012-01-01

To compare the epidemiological and economic impact of additional cross-protection against oncogenic human papillomavirus (HPV) types beyond 16/18 of the bivalent vaccine (BV) versus protection against nononcogenic HPV types 6/11 of the quadrivalent vaccine (QV) in Taiwan. A lifetime Markov model calibrated to the Taiwanese setting simulated the natural history of low-risk (engendering cervical intraepithelial neoplasia [CIN] 1 and genital warts) and high-risk HPV (engendering CIN1, CIN2/3, and cervical cancer [CC]) infections, screening, and vaccination (100% coverage) for a cohort of 12-year-old girls (N = 153,000). Transition probabilities, costs, and utilities were estimated from published data and expert opinion. Vaccine efficacy was obtained from each vaccine's respective clinical trials. Price-parity and lifelong protection was assumed for both vaccines. The number of CIN lesions, CC cases, CC deaths and genital wart (GW) cases, and quality-adjusted life-years were estimated. Costs and outcomes (discounted at 3% and 1.5%, respectively) were compared from a payer's perspective. The model estimated that the BV led to an additional, undiscounted, 11,484 CIN1, 1,779 (+34.3% vs. QV) CIN2/3, 188 (+29.0% vs. QV) CC, and 69 (+29.0% vs. QV) CC deaths prevented compared with the QV, while the QV prevented 4,150 GW (+71%). This resulted in an additional 768 quality-adjusted life-years (QALY) and 11.6 million new Taiwan dollars costs saved for the BV versus the QV after discounting. Both vaccines have a different epidemiological impact with an increased number of CC-related lesions potentially prevented for the BV because of additional cross-protection. In the Taiwanese setting, HPV mass vaccination using the BV was estimated to dominate vaccination using the QV. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.

PubMed

Luciano, Brenda S; Hsu, Sang; Channavajhala, Padma L; Lin, Lih-Ling; Cuozzo, John W

2004-12-10

Cot/Tpl2/MAP3K8 is a serine/threonine kinase known to activate the ERK, p38, and JNK kinase pathways. Studies of Tpl2 knock-out mice reveal a clear defect in tumor necrosis factor-alpha production, although very little detail is known about its regulation and the signaling events involved. In the present study we demonstrated that phosphorylation of Cot was required for its maximal activity as phosphatase treatment of Cot decreased its kinase activity. The Cot sequence contains a conserved threonine at position 290 in the activation loop of the kinase domain. We found that mutation of this residue to alanine eliminated its ability to activate MEK/ERK and NF-kappaB pathways, whereas a phosphomimetic mutation to aspartic acid could rescue the ability to activate MEK. Thr-290 was also required for robust autophosphorylation of Cot. Antibody generated to phospho-Thr-290-Cot recognized both wild-type and kinase-dead Cot, suggesting that phosphorylation of Thr-290 did not occur through autophosphorylation but via another kinase. We showed that Cot was constitutively phosphorylated at Thr-290 in transfected human embryonic kidney 293T cells as well as human monocytes as this residue was phosphorylated in unstimulated and lipopolysaccharide-stimulated cells to the same degree. Treatment with herbimycin A inhibited Cot activity in the MEK/ERK pathway but did not inhibit phosphorylation at Thr-290. Together these results showed that phosphorylation of Cot at Thr-290 is necessary but not sufficient for full kinase activity in the MEK/ERK pathway.

20 CFR 661.290 - Under what circumstances may States require Local Boards to take part in regional planning...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Local Boards to take part in regional planning activities? 661.290 Section 661.290 Employees' Benefits... what circumstances may States require Local Boards to take part in regional planning activities? (a...) Participate in a regional planning process that results in regional performance measures for workforce...

32 CFR 290.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Definitions. 290.5 Section 290.5 National... Definitions. The terms used in this rule with the exception of the following are defined in DCAAP 5410.14. (a... means. This does not include computer software, which is the tool by which to create, store, or retrieve...

12 CFR 550.290 - What must I do with fiduciary funds awaiting investment or distribution?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What must I do with fiduciary funds awaiting investment or distribution? 550.290 Section 550.290 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FIDUCIARY POWERS OF SAVINGS ASSOCIATIONS Exercising Fiduciary Powers Funds...

18 CFR Appendix A to Part 290 - Nonexempt Electric Utilities

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Nonexempt Electric... 1978 Pt. 290, App. A Appendix A to Part 290—Nonexempt Electric Utilities Electric utilities that are... follows: Department of Water and Power of the City of Los Angeles, California. Pacific Gas & Electric Co...

18 CFR Appendix A to Part 290 - Nonexempt Electric Utilities

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Nonexempt Electric... 1978 Pt. 290, App. A Appendix A to Part 290—Nonexempt Electric Utilities Electric utilities that are... follows: Department of Water and Power of the City of Los Angeles, California. Pacific Gas & Electric Co...

18 CFR Appendix A to Part 290 - Nonexempt Electric Utilities

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Nonexempt Electric... 1978 Pt. 290, App. A Appendix A to Part 290—Nonexempt Electric Utilities Electric utilities that are... follows: Department of Water and Power of the City of Los Angeles, California. Pacific Gas & Electric Co...

18 CFR Appendix A to Part 290 - Nonexempt Electric Utilities

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Nonexempt Electric... 1978 Pt. 290, App. A Appendix A to Part 290—Nonexempt Electric Utilities Electric utilities that are... follows: Department of Water and Power of the City of Los Angeles, California. Pacific Gas & Electric Co...

18 CFR Appendix A to Part 290 - Nonexempt Electric Utilities

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Nonexempt Electric... 1978 Pt. 290, App. A Appendix A to Part 290—Nonexempt Electric Utilities Electric utilities that are... follows: Department of Water and Power of the City of Los Angeles, California. Pacific Gas & Electric Co...

41 CFR 102-38.290 - What types of payment may we accept?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What types of payment may we accept? 102-38.290 Section 102-38.290 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL...

21 CFR 290.5 - Drugs; statement of required warning.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Drugs; statement of required warning. 290.5... (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.5 Drugs; statement of required warning... Controlled Substances Act shall, when dispensed to or for a patient, contain the following warning: “Caution...

21 CFR 290.5 - Drugs; statement of required warning.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drugs; statement of required warning. 290.5... (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.5 Drugs; statement of required warning... Controlled Substances Act shall, when dispensed to or for a patient, contain the following warning: “Caution...

21 CFR 290.5 - Drugs; statement of required warning.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Drugs; statement of required warning. 290.5... (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.5 Drugs; statement of required warning... Controlled Substances Act shall, when dispensed to or for a patient, contain the following warning: “Caution...

21 CFR 290.5 - Drugs; statement of required warning.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Drugs; statement of required warning. 290.5... (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.5 Drugs; statement of required warning... Controlled Substances Act shall, when dispensed to or for a patient, contain the following warning: “Caution...

21 CFR 290.5 - Drugs; statement of required warning.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Drugs; statement of required warning. 290.5... (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.5 Drugs; statement of required warning... Controlled Substances Act shall, when dispensed to or for a patient, contain the following warning: “Caution...

21 CFR 137.290 - Self-rising yellow corn meal.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Self-rising yellow corn meal. 137.290 Section 137... Cereal Flours and Related Products § 137.290 Self-rising yellow corn meal. Self-rising yellow corn meal conforms to the definition and standard of identity prescribed by § 137.270 for self-rising white corn meal...

76 FR 60582 - Buy America Waiver Notification

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... 1/ 2'' x 0.008 steel fiber with ultimate tensile strength of 290ksi for experimental use in Ultra... 0.008 steel fiber with ultimate tensile strength of 290ksi for experimental use in UHPC in Iowa. In... potential domestic manufacturers for 1/2'' x 0.008 steel fiber with ultimate tensile strength of 290ksi for...

21 CFR 137.290 - Self-rising yellow corn meal.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Self-rising yellow corn meal. 137.290 Section 137... Cereal Flours and Related Products § 137.290 Self-rising yellow corn meal. Self-rising yellow corn meal conforms to the definition and standard of identity prescribed by § 137.270 for self-rising white corn meal...

21 CFR 290.6 - Spanish-language version of required warning.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Spanish-language version of required warning. 290... (CONTINUED) DRUGS: GENERAL CONTROLLED DRUGS General Provisions § 290.6 Spanish-language version of required... of this drug to any person other than the patient for whom it was prescribed.” The Spanish version of...

Publications - GMC 290 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 290 Publication Details Title: Organic carbon and rock-eval pyrolysis data of cuttings from Reference Unknown, 1999, Organic carbon and rock-eval pyrolysis data of cuttings from the Husky Oil NPR Products Report Report Information gmc290.pdf (177.0 K) Keywords Pyrolysis; Rock-Eval Pyrolysis Top of Page

Chikusetsusaponin IVa methyl ester induces cell cycle arrest by the inhibition of nuclear translocation of β-catenin in HCT116 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Kyung-Mi; Yun, Ji Ho; Lee, Dong Hwa

2015-04-17

We demonstrate that chikusetsusaponin IVa methyl ester (CME), a triterpenoid saponin from the root of Achyranthes japonica, has an anticancer activity. We investigate its molecular mechanism in depth in HCT116 cells. CME reduces the amount of β-catenin in nucleus and inhibits the binding of β-catenin to specific DNA sequences (TCF binding elements, TBE) in target gene promoters. Thus, CME appears to decrease the expression of cell cycle regulatory proteins such as Cyclin D1, as a representative target for β-catenin, as well as CDK2 and CDK4. As a result of the decrease of the cell cycle regulatory proteins, CME inhibits cellmore » proliferation by arresting the cell cycle at the G0/G1 phase. Therefore, we suggest that CME as a novel Wnt/β-catenin inhibitor can be a putative agent for the treatment of colorectal cancers. - Highlights: • CME inhibits cell proliferation in HCT116 cells. • CME increases cell cycle arrest at G0/G1 phase and apoptosis. • CME attenuates cyclin D1 and regulates cell cycle regulatory proteins. • CME inhibits β-catenin translocation to nucleus.« less

[Determination of heavy metals in four traditional Chinese medicines by ICP-MS].

PubMed

Wen, Hui-Min; Chen, Xiao-Hui; Dong, Ting-Xia; Zhan, Hua-Qiang; Bi, Kai-Shun

2006-08-01

To establish a ICP-MS method for the determination of heavy metals, including As, Hg, Pb, Cd, in four traditional Chinese medicines. The samples were digested by closed-versel microwave. The four heavy metals were directly analyzed by ICP-MS. Select internal standard element in for the method by which the analyse signal drife is corrected by the signal of another element (internal standard elements) added to both the standard solution and sample. For all of the analyzed heary methals, the correlative coefficient of the calibration curves was over 0.999 2. The recovery rates of the procedure were 97.5%-108.0%, and its RSD was lower than 11.6%. This method was convenient, quick-acquired, accurate and highly sensitive. The method can be used for the quality control of trace elements in traditional Chinese medicines and for the contents determination of traditional Chinese medicines from different habitats and species.

49 CFR 174.290 - Materials extremely poisonous by inhalation shipped by, for, or to the Department of Defense.

Code of Federal Regulations, 2012 CFR

2012-10-01

... shipped by, for, or to the Department of Defense. 174.290 Section 174.290 Transportation Other Regulations... described in paragraph (b) of this section, must be accompanied by a Department of Defense qualified escort... Department of Defense specifications. When a shipment is loaded in a gondola car it must be securely blocked...

49 CFR 174.290 - Materials extremely poisonous by inhalation shipped by, for, or to the Department of Defense.

Code of Federal Regulations, 2014 CFR

2014-10-01

... shipped by, for, or to the Department of Defense. 174.290 Section 174.290 Transportation Other Regulations... described in paragraph (b) of this section, must be accompanied by a Department of Defense qualified escort... Department of Defense specifications. When a shipment is loaded in a gondola car it must be securely blocked...

49 CFR 174.290 - Materials extremely poisonous by inhalation shipped by, for, or to the Department of Defense.

Code of Federal Regulations, 2011 CFR

2011-10-01

... shipped by, for, or to the Department of Defense. 174.290 Section 174.290 Transportation Other Regulations... described in paragraph (b) of this section, must be accompanied by a Department of Defense qualified escort... Department of Defense specifications. When a shipment is loaded in a gondola car it must be securely blocked...

49 CFR 174.290 - Materials extremely poisonous by inhalation shipped by, for, or to the Department of Defense.

Code of Federal Regulations, 2013 CFR

2013-10-01

... shipped by, for, or to the Department of Defense. 174.290 Section 174.290 Transportation Other Regulations... described in paragraph (b) of this section, must be accompanied by a Department of Defense qualified escort... Department of Defense specifications. When a shipment is loaded in a gondola car it must be securely blocked...

41 CFR 102-34.290 - What forms do I use to report a crash involving a domestic fleet motor vehicle?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What forms do I use to report a crash involving a domestic fleet motor vehicle? 102-34.290 Section 102-34.290 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT...

Applying the silver-tube introduction method for thermal conversion elemental analyses and a new δ2H value for NBS 22 oil

USGS Publications Warehouse

Coplen, Tyler B.; Qi, Haiping

2010-01-01

The δ2HVSMOW–SLAP value of total hydrogen of the international measurement standard NBS 22 oil was determined by a new method of sealing water in silver tubes for use in a thermal conversion elemental analysis (TC/EA) reduction unit. The isotopic fractionation of water due to evaporation is virtually non-existent in this silver-tube method. A new value for the δ2HVSMOW–SLAP of NBS 22 oil, calibrated with isotopic reference waters, was determined to be −116.9 ± 0.8‰ (1σ and n = 31).

The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells.

PubMed

Yuan, Kai; Ai, Wen-Bing; Wan, Lin-Yan; Tan, Xiao; Wu, Jiang-Feng

2017-01-01

Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in the mouse embryonic stem cells and involved in various biological processes. In this paper, we reviewed the research progress of the function of the miR-290-295 cluster in embryonic stem cells. The miR-290-295 cluster is involved in regulating embryonic stem cell pluripotency maintenance, self-renewal, and reprogramming somatic cells to an embryonic stem cell-like state. Moreover, the miR-290-295 cluster has a latent pro-survival function in embryonic stem cells and involved in tumourigenesis and senescence with a great significance. Elucidating the interaction between the miR-290-295 cluster and other modes of gene regulation will provide us new ideas on the biology of pluripotent stem cells. In the near future, the broad prospects of the miRNA cluster will be shown in the stem cell field, such as altering cell identities with high efficiency through the transient introduction of tissue-specific miRNA cluster.

Determination of trace elements in honey from different regions in Rio de Janeiro State (Brazil) by total reflection X-ray fluorescence.

PubMed

Ribeiro, Roberta de Oliveira Resende; Mársico, Eliane Teixeira; de Jesus, Edgar Francisco Oliveira; da Silva Carneiro, Carla; Júnior, Carlos Adam Conte; de Almeida, Eduardo; Filho, Virgílio Franco do Nascimento

2014-04-01

Trace and minor elements in Brazilian honey were analyzed by total reflection X-ray fluorescence spectroscopy. Up to 12 elements (K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Se, Br, and Sr) were detected in 160 samples of honey from 4 regions of Rio de Janeiro State (Barra Mansa, Teresópolis, northern and southern Nova Friburgo). The results showed the samples from Teresópolis had higher rates of essential and nonessential elements than samples from the other regions, except for Ni. K and Ca were the most abundant elements in all samples, in the range of 116.5 to 987.0 μg g(-1) . Ni, Cu, Zn, Se, and Sr were identified in small concentrations (0.01 to 12.08 μg g(-1) ) in all samples, indicating a low level of contamination in all the regions. © 2014 Institute of Food Technologists®

ICD-10 procedure codes produce transition challenges

PubMed Central

Boyd, Andrew D.; Li, Jianrong ‘John’; Kenost, Colleen; Zaim, Samir Rachid; Krive, Jacob; Mittal, Manish; Satava, Richard A.; Burton, Michael; Smith, Jacob; Lussier, Yves A.

2018-01-01

The transition of procedure coding from ICD-9-CM-Vol-3 to ICD-10-PCS has generated problems for the medical community at large resulting from the lack of clarity required to integrate two non-congruent coding systems. We hypothesized that quantifying these issues with network topology analyses offers a better understanding of the issues, and therefore we developed solutions (online tools) to empower hospital administrators and researchers to address these challenges. Five topologies were identified: “identity”(I), “class-to-subclass”(C2S), “subclass-toclass”(S2C), “convoluted(C)”, and “no mapping”(NM). The procedure codes in the 2010 Illinois Medicaid dataset (3,290 patients, 116 institutions) were categorized as C=55%, C2S=40%, I=3%, NM=2%, and S2C=1%. Majority of the problematic and ambiguous mappings (convoluted) pertained to operations in ophthalmology cardiology, urology, gyneco-obstetrics, and dermatology. Finally, the algorithms were expanded into a user-friendly tool to identify problematic topologies and specify lists of procedural codes utilized by medical professionals and researchers for mitigating error-prone translations, simplifying research, and improving quality.http://www.lussiergroup.org/transition-to-ICD10PCS PMID:29888037

Depth-varying density and organization of chondrocytes in immature and mature bovine articular cartilage assessed by 3d imaging and analysis.

PubMed

Jadin, Kyle D; Wong, Benjamin L; Bae, Won C; Li, Kelvin W; Williamson, Amanda K; Schumacher, Barbara L; Price, Jeffrey H; Sah, Robert L

2005-09-01

Articular cartilage is a heterogeneous tissue, with cell density and organization varying with depth from the surface. The objectives of the present study were to establish a method for localizing individual cells in three-dimensional (3D) images of cartilage and quantifying depth-associated variation in cellularity and cell organization at different stages of growth. Accuracy of nucleus localization was high, with 99% sensitivity relative to manual localization. Cellularity (million cells per cm3) decreased from 290, 310, and 150 near the articular surface in fetal, calf, and adult samples, respectively, to 120, 110, and 50 at a depth of 1.0 mm. The distance/angle to the nearest neighboring cell was 7.9 microm/31 degrees , 7.1 microm/31 degrees , and 9.1 microm/31 degrees for cells at the articular surface of fetal, calf, and adult samples, respectively, and increased/decreased to 11.6 microm/31 degrees , 12.0 microm/30 degrees , and 19.2 microm/25 degrees at a depth of 0.7 mm. The methodologies described here may be useful for analyzing the 3D cellular organization of cartilage during growth, maturation, aging, degeneration, and regeneration.

Depth-varying density and organization of chondrocytes in immature and mature bovine articular cartilage assessed by 3d imaging and analysis

NASA Technical Reports Server (NTRS)

Jadin, Kyle D.; Wong, Benjamin L.; Bae, Won C.; Li, Kelvin W.; Williamson, Amanda K.; Schumacher, Barbara L.; Price, Jeffrey H.; Sah, Robert L.

2005-01-01

Articular cartilage is a heterogeneous tissue, with cell density and organization varying with depth from the surface. The objectives of the present study were to establish a method for localizing individual cells in three-dimensional (3D) images of cartilage and quantifying depth-associated variation in cellularity and cell organization at different stages of growth. Accuracy of nucleus localization was high, with 99% sensitivity relative to manual localization. Cellularity (million cells per cm3) decreased from 290, 310, and 150 near the articular surface in fetal, calf, and adult samples, respectively, to 120, 110, and 50 at a depth of 1.0 mm. The distance/angle to the nearest neighboring cell was 7.9 microm/31 degrees , 7.1 microm/31 degrees , and 9.1 microm/31 degrees for cells at the articular surface of fetal, calf, and adult samples, respectively, and increased/decreased to 11.6 microm/31 degrees , 12.0 microm/30 degrees , and 19.2 microm/25 degrees at a depth of 0.7 mm. The methodologies described here may be useful for analyzing the 3D cellular organization of cartilage during growth, maturation, aging, degeneration, and regeneration.

30 CFR 290.107 - Where are the rules concerning the effect of the Department not issuing a decision in my appeal...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Where are the rules concerning the effect of the Department not issuing a decision in my appeal within the statutory time frame? 290.107 Section... PROCEDURES Minerals Revenue Management Appeal Procedures § 290.107 Where are the rules concerning the effect...

25 CFR 290.8 - Do Indian tribes have to make per capita payments from net gaming revenues to tribal members?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Do Indian tribes have to make per capita payments from net gaming revenues to tribal members? 290.8 Section 290.8 Indians BUREAU OF INDIAN AFFAIRS... to make per capita payments from net gaming revenues to tribal members? No. You do not have to make...

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone

PubMed Central

Li, Chunmei; Kennedy, Julie; Garcia-Gonzalo, Francesc R.; Romani, Marta; De Mori, Roberta; Bruel, Ange-Line; Gaillard, Dominique; Doray, Bérénice; Lopez, Estelle; Rivière, Jean-Baptiste; Faivre, Laurence; Thauvin-Robinet, Christel; Reiter, Jeremy F.; Blacque, Oliver E.; Valente, Enza Maria; Leroux, Michel R.

2016-01-01

Cilia have a unique diffusion barrier (“gate”) within their proximal region, termed transition zone (TZ), that compartmentalises signalling proteins within the organelle. The TZ is known to harbour two functional modules/complexes (Meckel syndrome [MKS] and Nephronophthisis [NPHP]) defined by genetic interaction, interdependent protein localisation (hierarchy), and proteomic studies. However, the composition and molecular organisation of these modules and their links to human ciliary disease are not completely understood. Here, we reveal Caenorhabditis elegans CEP-290 (mammalian Cep290/Mks4/Nphp6 orthologue) as a central assembly factor that is specific for established MKS module components and depends on the coiled coil region of MKS-5 (Rpgrip1L/Rpgrip1) for TZ localisation. Consistent with a critical role in ciliary gate function, CEP-290 prevents inappropriate entry of membrane-associated proteins into cilia and keeps ARL-13 (Arl13b) from leaking out of cilia via the TZ. We identify a novel MKS module component, TMEM-218 (Tmem218), that requires CEP-290 and other MKS module components for TZ localisation and functions together with the NPHP module to facilitate ciliogenesis. We show that TZ localisation of TMEM-138 (Tmem138) and CDKL-1 (Cdkl1/Cdkl2/Cdkl3/Cdlk4 related), not previously linked to a specific TZ module, similarly depends on CEP-290; surprisingly, neither TMEM-138 or CDKL-1 exhibit interdependent localisation or genetic interactions with core MKS or NPHP module components, suggesting they are part of a distinct, CEP-290-associated module. Lastly, we show that families presenting with Oral-Facial-Digital syndrome type 6 (OFD6) have likely pathogenic mutations in CEP-290-dependent TZ proteins, namely Tmem17, Tmem138, and Tmem231. Notably, patient fibroblasts harbouring mutated Tmem17, a protein not yet ciliopathy-associated, display ciliogenesis defects. Together, our findings expand the repertoire of MKS module-associated proteins—including the previously uncharacterised mammalian Tmem80—and suggest an MKS-5 and CEP-290-dependent assembly pathway for building a functional TZ. PMID:26982032

Fragmentation Cross Sections of 290 and 400 MeV/nucleon 12C Beamson Elemental Targets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeitlin, C.; Guetersloh, S.; Heilbronn, L.

Charge-changing and fragment production cross sections at 0circ have been obtained for interactions of 290 MeV/nucleon and 400MeV/nucleon carbon beams with C, CH2, Al, Cu, Sn, and Pb targets. Thesebeams are relevant to cancer therapy, space radiation, and the productionof radioactive beams. We compare to previously published results using Cand CH2 targets at similar beam energies. Due to ambiguities arising fromthe presence of multiple fragments on many events, previous publicationshave reported only cross sections for B and Be fragments. In this work wehave extracted cross sections for all fragment species, using dataobtained at three distinct values of angular acceptance, supplementedmore » bydata taken with the detector stack placed off the beam axis. A simulationof the experiment with the PHITS Monte Carlo code shows fair agreementwith the data obtained with the large acceptance detectors, but agreementis poor at small acceptance. The measured cross sections are alsocompared to the predictions of the one-dimensional cross section modelsEPAX2 and NUCFRG2; the latter is presently used in NASA's space radiationtransport calculations. Though PHITS and NUCFRG2 reproduce thecharge-changing cross sections with reasonable accuracy, none of themodels is able to accurately predict the fragment cross sections for allfragment species and target materials.« less

Characteristics of thermally-induced transverse cracks in graphite epoxy composite laminates

NASA Technical Reports Server (NTRS)

Adams, D. S.; Bowles, D. E.; Herakovich, C. T.

1983-01-01

The characteristics of thermally induced transverse cracks in T300/5208 graphite-epoxy cross-ply and quasi-isotropic laminates were investigated both experimentally and analytically. The formation of transverse cracks and the subsequent crack spacing present during cool down to -250 F (116K) and thermal cycling between 250 and -250 F (116 and 394K) was investigated. The state of stress in the vicinity of a transverse crack and the influence of transverse cracking on the laminate coefficient of thermal expansion (CTE) was predicted using a generalized plane strain finite element analysis and a modified shear lag analysis. A majority of the cross-ply laminates experienced transverse cracking during the initial cool down to -250 F whereas the quasi-isotropic laminates remained uncracked. The in situ transverse strength of the 90 degree layers was more than 1.9 times greater than the transverse strength of the unidirectional 90 degree material for all laminates investigated.

Key sources and distribution patterns of particulate material in the South Atlantic: data from the UK GEOTRACES A10 cruise

NASA Astrophysics Data System (ADS)

Milne, A.; Palmer, M.; Lohan, M. C.

2016-02-01

Particles play a fundamental role in the biogeochemical cycling of both major- and micro-nutrients in marine systems, including trace elements and isotopes. However, knowledge of particulate distributions, and their potential to regulate dissolved elemental concentrations, remains limited and poorly understood. The paradox is, that the oceanic inventory of trace metals is dominated by particulate inputs (e.g. aerosol deposition, shelf sediment resuspension). Moreover the labile fraction of particulate trace elements could be an important regulator of dissolved concentrations. Here we present particulate data from the UK GEOTRACES South Atlantic transect (GA10) from South Africa to Uruguay. Data from a range of elements (e.g. Fe, Al, Mn) revealed a greater input of particulate metals from the Argentine shelf (up to 290 nM of pFe) in comparison to the South African shelf (< 40 nM of pFe). Overall, higher concentrations of all metals were observed in the bottom waters of the Argentine basin and penetrated deeper up the water column (up to 1300 m), a result of intense benthic storms. The imprint of leakage from the Agulhas Current, identified through temperature and salinity, was observed in the upper water column profile of numerous particulate data (e.g. Pb, Ni, Cd). Measured elemental gradients, combined with measurements from a vertical mixing-profiler, will allow estimates of particulate fluxes to be calculated.

KSC-06pd2382

NASA Image and Video Library

2006-07-05

JOHNSON SPACE CENTER, Houston, Texas -- STS116-S-001 (July 2006) - The STS-116 patch design signifies the continuing assembly of the International Space Station (ISS). The primary mission objective is to deliver and install the P5 truss element. The P5 installation will be conducted during the first of three planned spacewalks, and will involve use of both the shuttle and station robotic arms. The remainder of the mission will include a major reconfiguration and activation of the ISS electrical and thermal control systems, as well as delivery of Zvezda Service Module debris panels, which will increase ISS protection from potential impacts of micro-meteorites and orbital debris. In addition, a single expedition crew member will launch on STS-116 to remain onboard the station, replacing an expedition crew member who will fly home with the shuttle crew. The crew patch depicts the space shuttle rising above the Earth and ISS. The United States and Swedish flags trail the orbiter, depicting the international composition of the STS-116 crew. The seven stars of the constellation Ursa Major are used to provide direction to the North Star, which is superimposed over the installation location of the P5 truss on ISS. The NASA insignia design for space shuttle space flights is reserved for use by the astronauts and other official use as the NASA Administrator may authorize. Public availability has been approved only in the form of illustrations by the various news media. When and if there is any change in this policy, which is not anticipated, such will be publicly announced.

Cell Context Dependent p53 Genome-Wide Binding Patterns and Enrichment at Repeats

DOE PAGES

Botcheva, Krassimira; McCorkle, Sean R.

2014-11-21

The p53 ability to elicit stress specific and cell type specific responses is well recognized, but how that specificity is established remains to be defined. Whether upon activation p53 binds to its genomic targets in a cell type and stress type dependent manner is still an open question. Here we show that the p53 binding to the human genome is selective and cell context-dependent. We mapped the genomic binding sites for the endogenous wild type p53 protein in the human cancer cell line HCT116 and compared them to those we previously determined in the normal cell line IMR90. We reportmore » distinct p53 genome-wide binding landscapes in two different cell lines, analyzed under the same treatment and experimental conditions, using the same ChIP-seq approach. This is evidence for cell context dependent p53 genomic binding. The observed differences affect the p53 binding sites distribution with respect to major genomic and epigenomic elements (promoter regions, CpG islands and repeats). We correlated the high-confidence p53 ChIP-seq peaks positions with the annotated human repeats (UCSC Human Genome Browser) and observed both common and cell line specific trends. In HCT116, the p53 binding was specifically enriched at LINE repeats, compared to IMR90 cells. The p53 genome-wide binding patterns in HCT116 and IMR90 likely reflect the different epigenetic landscapes in these two cell lines, resulting from cancer-associated changes (accumulated in HCT116) superimposed on tissue specific differences (HCT116 has epithelial, while IMR90 has mesenchymal origin). In conclusion, our data support the model for p53 binding to the human genome in a highly selective manner, mobilizing distinct sets of genes, contributing to distinct pathways.« less

Finite element simulations of the Portevin Le Chatelier effect in aluminium alloy

NASA Astrophysics Data System (ADS)

Hopperstad, O. S.; Børvik, T.; Berstad, T.; Benallal, A.

2006-08-01

Finite element simulations of the Portevin-Le Chatelier effect in aluminium alloy 5083-H116 are presented and evaluated against existing experimental results. The constitutive model of McCormick (1988) for materials exhibiting negative steady-state strain-rate sensitivity is incorporated into an elastic-viscoplastic model for large plastic deformations and implemented in LS-DYNA for use with the explicit or implicit solver. Axisymmetric tensile specimens loaded at different strain rates are studied numerically, and it is shown that the model predicts the experimental behaviour with reasonable accuracy; including serrated yielding and propagating bands of localized plastic deformation along the gauge length of the specimen at intermediate strain rates.

Research misconduct oversight: defining case costs.

PubMed

Gammon, Elizabeth; Franzini, Luisa

2013-01-01

This study uses a sequential mixed method study design to define cost elements of research misconduct among faculty at academic medical centers. Using time driven activity based costing, the model estimates a per case cost for 17 cases of research misconduct reported by the Office of Research Integrity for the period of 2000-2005. Per case cost of research misconduct was found to range from $116,160 to $2,192,620. Research misconduct cost drivers are identified.

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Study

PubMed Central

Heij, Lara; Niesters, Marieke; Swartjes, Maarten; Hoitsma, Elske; Drent, Marjolein; Dunne, Ann; Grutters, Jan C; Vogels, Oscar; Brines, Michael; Cerami, Anthony; Dahan, Albert

2012-01-01

ARA 290 (a peptide designed to activate the innate repair receptor that arrests injury and initiates cytoprotection, antiinflammation and healing) reduces allodynia in preclinical neuropathy models. We studied the safety and efficacy of ARA 290 to reduce symptoms of small fiber neuropathy (SFN) in patients with sarcoidosis. A total of 22 patients diagnosed with sarcoidosis and symptoms of SFN were enrolled in a double-blind, placebo-controlled exploratory trial consisting of three times weekly intravenous dosing of ARA 290 (2 mg; n = 12) or placebo (n = 10) for 4 wks. Inclusion criteria were a diagnosis of neuropathy and a spontaneous pain score of ≥5 (Brief Pain Inventory [BPI]). Endpoints assessed were changes in pain intensity and the small fiber neuropathy screening list (SFNSL) score, quality of life (SF-36), depressive symptoms (Inventory of Depressive Symptomatology [IDS]) and fatigue (Fatigue Assessment Scale [FAS]). No safety concerns were raised by clinical or laboratory assessments. The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in SFNSL score compared with placebo (Δ −11.5 ± 3.04 versus Δ −2.9 ± 3.34 [standard error of the mean]). Additionally, the ARA 290 group showed a significant change from baseline in the pain and physical functioning dimensions of the SF-36 (Δ −23.4 ± 5.5 and Δ −14.6 ± 3.9, respectively). The mean BPI and FAS scores improved significantly but equivalently in both patient groups. No change was observed in the IDS. ARA 290 appears to be safe in patients with sarcoidosis and can reduce neuropathic symptoms. PMID:23168581

Dipole defects in MgAl2O4 spinel crystals

NASA Astrophysics Data System (ADS)

Ayres, F.; de Souza, S. S.; Blak, A. R.

In order to study defects of dipole origin in normal and inverse spinel structures, Thermally Stimulated Depolarisation Current (TSDC) measurements have been carried out in MgAl2O4 spinel crystals doped with Fe, Cr, Mn and Co. The TSDC spectrum of the as-received sample labelled R shows two bands at 160K and 290K. Temperatures above 700K destroy the 290K band and γ-irradiation up to 1,500kGy restores the peak. In another sample labelled UC, the 290K band, of dipole origin, is only detected after γ-irradiation. The dipole origin of the 160K band has already been verified. This band is affected neither by γ-irradiation nor by thermal treatment. The reduction of the 290K band is observed when heating the samples between 350K and 480K for three minutes at each temperature. The correlation between the thermal reduction of the 290K band and the study of V-centres in MgAl2O4 spinels indicates the possible attribution of the band to V-type centres.

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2012 CFR

2012-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2014 CFR

2014-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

Quasifree analyzing powers using the (p-->,n) reaction

NASA Astrophysics Data System (ADS)

Hicks, K. H.; Vetterli, M. C.; Celler, A.; Helmer, R. L.; Henderson, R. S.; Jackson, K. P.; Jeppesen, R. G.; Trudel, A.; Yen, S.

1989-12-01

The (p-->,n) reaction has been measured for 12C and 54Fe targets at 290 MeV for a lab angle of 20.4° and at 420 MeV for a lab angle of 24.0°. An additional angle of 27.0° was measured for 12C at 290 MeV. Both cross sections and analyzing powers were obtained up to excitation energies close to the quasifree peak. The (p-->,n) analyzing powers are suppressed relative to the free nucleon-nucleon values for the 12C data at 290 and 420 MeV, and for the 54Fe data at 290 MeV. An enhanced analyzing power is observed for the 54Fe data at 420 MeV. The data are compared with both relativistic and nonrelativistic model calculations.

Erosion of fluorinated diamond-like carbon films by exposure to soft X-rays

NASA Astrophysics Data System (ADS)

Kanda, Kazuhiro; Takamatsu, Hiroki; Miura-Fujiwara, Eri; Akasaka, Hiroki; Saiga, Akihiro; Tamada, Koji

2018-04-01

The effects of soft X-ray irradiation on fluorinated diamond-like carbon (F-DLC) films were investigated using synchrotron radiation (SR). The Vickers hardness of the F-DLC films substantially increased from an initial value of about 290 to about 800 HV at a dose of 50 mA·h and the remained constant at about 1100 HV at doses of more than 300 mA·h. This dose dependence was consistent with those of the film thickness and elemental composition. The depth profile of the elemental composition inside each F-DLC film obtained by the measurement of the X-ray photoelectron spectrum (XPS) during sputtering showed that the composition ratio of fluorine was approximately constant from the surface to the neighborhood of the substrate. Namely, fluorine atoms were desorbed by SR irradiation from not only the surface but also the substrate neighborhood. Modification by SR irradiation was found to occur in the entire F-DLC film of about 200 nm thickness.

UV Radiation–Sensitive Norin 1 Rice Contains Defective Cyclobutane Pyrimidine Dimer Photolyase

PubMed Central

Hidema, Jun; Kumagai, Tadashi; Sutherland, Betsy M.

2000-01-01

Norin 1, a progenitor of many economically important Japanese rice strains, is highly sensitive to the damaging effects of UVB radiation (wavelengths 290 to 320 nm). Norin 1 seedlings are deficient in photorepair of cyclobutane pyrimidine dimers. However, the molecular origin of this deficiency was not known and, because rice photolyase genes have not been cloned and sequenced, could not be determined by examining photolyase structural genes or upstream regulatory elements for mutations. We therefore used a photoflash approach, which showed that the deficiency in photorepair in vivo resulted from a functionally altered photolyase. These results were confirmed by studies with extracts, which showed that the Norin 1 photolyase–dimer complex was highly thermolabile relative to the wild-type Sasanishiki photolyase. This deficiency results from a structure/function alteration of photolyase rather than of nonspecific repair, photolytic, or regulatory elements. Thus, the molecular origin of this plant DNA repair deficiency, resulting from a spontaneously occurring mutation to UV radiation sensitivity, is defective photolyase. PMID:11006332

Studies on a 300 k pixel detector telescope

NASA Astrophysics Data System (ADS)

Middelkamp, Peter; Antinori, F.; Barberis, D.; Becks, K. H.; Beker, H.; Beusch, W.; Burger, P.; Campbell, M.; Cantatore, E.; Catanesi, M. G.; Chesi, E.; Darbo, G.; D'Auria, S.; Davia, C.; di Bari, D.; di Liberto, S.; Elia, D.; Gys, T.; Heijne, E. H. M.; Helstrup, H.; Jacholkowski, A.; Jæger, J. J.; Jakubek, J.; Jarron, P.; Klempt, W.; Krummenacher, F.; Knudson, K.; Kralik, I.; Kubasta, J.; Lasalle, J. C.; Leitner, R.; Lemeilleur, F.; Lenti, V.; Letheren, M.; Lopez, L.; Loukas, D.; Luptak, M.; Martinengo, P.; Meddeler, G.; Meddi, F.; Morando, M.; Munns, A.; Pellegrini, F.; Pengg, F.; Pospisil, S.; Quercigh, E.; Ridky, J.; Rossi, L.; Safarik, K.; Scharfetter, L.; Segato, G.; Simone, S.; Smith, K.; Snoeys, W.; Vrba, V.

1996-02-01

Four silicon pixel detector planes are combined to form a tracking telescope in the lead ion experiment WA97 at CERN with 290 304 sensitive elements each of 75 μm by 500 μm area. An electronic pulse processing circuit is associated with each individual sensing element and the response for ionizing particles is binary with an adjustable threshold. The noise rate for a threshold of 6000 e- has been measured to be less than 10-10. The inefficient area due to malfunctioning pixels is 2.8% of the 120 cm2. Detector overlaps within one plane have been used to determine the alignment of the components of the plane itself, without need for track reconstruction using external detectors. It is the first time that such a big surface covered with active pixels has been used in a physics experiment. Some aspects concerning inclined particle tracks and time walk have been measured separately in a beam test at the CERN SPS H6 beam.

Financial Relationships between Organizations That Produce Clinical Practice Guidelines and the Biomedical Industry: A Cross-Sectional Study.

PubMed

Campsall, Paul; Colizza, Kate; Straus, Sharon; Stelfox, Henry T

2016-05-01

Financial relationships between organizations that produce clinical practice guidelines and biomedical companies are vulnerable to conflicts of interest. We sought to determine whether organizations that produce clinical practice guidelines have financial relationships with biomedical companies and whether there are associations between organizations' conflict of interest policies and recommendations and disclosures provided in guidelines. We conducted a cross-sectional survey and review of websites of 95 national/international medical organizations that produced 290 clinical practice guidelines published on the National Guideline Clearinghouse website from January 1 to December 31, 2012. Survey responses were available for 68% (65/95) of organizations (167/290 guidelines, 58%), and websites were reviewed for 100% (95/95) of organizations (290/290 guidelines, 100%). In all, 63% (60/95) of organizations producing clinical practice guidelines reported receiving funds from a biomedical company; 80% (76/95) of organizations reported having a policy for managing conflicts of interest. Disclosure statements (disclosing presence or absence of financial relationships with biomedical companies) were available in 65% (188/290) of clinical practice guidelines for direct funding sources to produce the guideline, 51% (147/290) for financial relationships of the guideline committee members, and 1% (4/290) for financial relationships of the organizations producing the guidelines. Among all guidelines, 6% (18/290) disclosed direct funding by biomedical companies, 40% (117/290) disclosed financial relationships between committee members and biomedical companies (38% of guideline committee members, 773/2,043), and 1% (4/290) disclosed financial relationships between the organizations producing the guidelines and biomedical companies. In the survey responses, 60 organizations reported the procedures that they included in their conflict of interest policies (158 guidelines): guidelines produced by organizations reporting more comprehensive conflict of interest policies (per additional procedure, range 5-17) included fewer positive (rate ratio [RR] 0.91, 95% CI 0.86-0.95) and more negative (RR 1.32, 95% CI 1.09-1.60) recommendations regarding patented biomedical products. The clinical practice guidelines produced by organizations reporting more comprehensive conflict of interest policies were also more likely to include disclosure statements for direct funding sources (odds ratio [OR] 1.31, 95% CI 1.10-1.56) and financial relationships of guideline committee members (OR 1.36, 95% CI 1.09-1.79), but not financial relationships of the organizations (0 disclosures). Limitations of the study include the use of the National Guideline Clearinghouse as the single source of clinical practice guidelines and the self-report of survey responses and organizations' website postings. Financial relationships between organizations that produce clinical practice guidelines and biomedical companies are common and infrequently disclosed in guidelines. Our study highlights the need for an effective policy to manage organizational conflicts of interest and disclosure of financial relationships.

Phytogeographical Analysis of Seed Plant Genera in China

PubMed Central

QIAN, HONG; WANG, SILONG; HE, JIN-SHENG; ZHANG, JUNLI; WANG, LISONG; WANG, XIANLI; GUO, KE

2006-01-01

• Background and Aims A central goal of biogeography and ecology is to uncover and understand distributional patterns of organisms. China has long been a focus of attention because of its rich biota, especially with respect to plants. Using 290 floras from across China, this paper quantitatively characterizes the composition of floristic elements at multiple scales (i.e. national, provincial and local), and explores the extent to which climatic and geographical factors associated with each flora can jointly and independently explain the variation in floristic elements in local floras. • Methods A study was made of 261 local floras, 28 province-level floras and one national-level flora across China. Genera of seed plants in each flora were assigned to 14 floristic elements according to their worldwide geographical distributions. The composition of floristic elements was related to climatic and geographical factors. • Key Results and Conclusions Variations in percentages of cosmopolitan, tropical and temperate genera among local floras tend to be greater at higher latitudes than at lower latitudes. Latitude is strongly correlated with the proportions of 13 of the 14 floristic elements. Correlations of the proportions of floristic elements with longitude are much weaker than those with latitude. Climate represented by the first principal component of a principal component analysis was strongly correlated with the proportions of floristic elements in local floras (|r| = 0·75 ± 0·18). Geographical coordinates independently explained about four times as much variation in floristic elements as did climate. Further research is necessary to examine the roles of water–energy dynamics, geology, soils, biotic interactions, and historical factors such as land connections between continents in the past and at present in creating observed floristic patterns. PMID:16945946

40 CFR 60.290 - Applicability and designation of affected facility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Glass Manufacturing Plants § 60.290 Applicability and designation of affected facility. (a...

Reading Level and Length of Written Research Consent Forms

PubMed Central

Foe, Gabriella; Lally, Rachel

2015-01-01

Abstract In 100 Institutional Review Board approved consent forms (CFs), we assessed pages, reading levels, and whether they included essential elements. CF page numbers ranged from 3 to 28 (mean, 10.3) and readability ranged from grades 5.6 to 28.9 (mean, 11.6). The CF mean score for including essential elements was 90.8% (range: 63.5–100%). There were no significant differences by specialty in number of pages (p = 0.053), but surgical specialties had the highest readability (mean, 13.1), and pediatrics the lowest (10.5), p = 0.008. While approved CFs generally included the Office for Human Research Protections recommended essential elements, they were very long, and even pediatric forms, which had the lowest reading levels, were written on average at a tenth grade level. Researchers need guidance to resolve pressure between regulatory mandates and guidelines and “keeping it simple and clear.” PMID:25580939

Buckling Testing and Analysis of Honeycomb Sandwich Panel Arc Segments of a Full-Scale Fairing Barrel: Comparison of In- and Out-of-Autoclave Facesheet Configurations

NASA Technical Reports Server (NTRS)

Pineda, Evan Jorge; Myers, David E.; Kosareo, Daniel N.; Zalewski, Bart F.; Kellas, Sotiris; Dixon, Genevieve D.; Krivanek, Thomas M.; Gyekenyesi, Thomas G.

2014-01-01

Four honeycomb sandwich panels, representing 1/16th arc segments of a 10-m diameter barrel section of the Heavy Lift Launch Vehicle, were manufactured and tested under the NASA Composites for Exploration and the NASA Constellation Ares V programs. Two configurations were chosen for the panels: 6-ply facesheets with 1.125 in. honeycomb core and 8-ply facesheets with 1.0 in. honeycomb core. Additionally, two separate carbon fiber/epoxy material systems were chosen for the facesheets: in-autoclave IM7/977-3 and out-of-autoclave T40-800b/5320-1. Smaller 3 ft. by 5 ft. panels were cut from the 1/16th barrel sections and tested under compressive loading. Furthermore, linear eigenvalue and geometrically nonlinear finite element analyses were performed to predict the compressive response of each 3 ft. by 5 ft. panel. To improve the robustness of the geometrically nonlinear finite element model, measured surface imperfections were included in the geometry of the model. Both the linear and nonlinear models yielded good qualitative and quantitative predictions. Additionally, it was correctly predicted that the panel would fail in buckling prior to failing in strength. Furthermore, several imperfection studies were performed to investigate the influence of geometric imperfections, fiber angle misalignments, and three-dimensional effects on the compressive response of the panel.

Test-retest reliability of infant event related potentials evoked by faces.

PubMed

Munsters, N M; van Ravenswaaij, H; van den Boomen, C; Kemner, C

2017-04-05

Reliable measures are required to draw meaningful conclusions regarding developmental changes in longitudinal studies. Little is known, however, about the test-retest reliability of face-sensitive event related potentials (ERPs), a frequently used neural measure in infants. The aim of the current study is to investigate the test-retest reliability of ERPs typically evoked by faces in 9-10 month-old infants. The infants (N=31) were presented with neutral, fearful and happy faces that contained only the lower or higher spatial frequency information. They were tested twice within two weeks. The present results show that the test-retest reliability of the face-sensitive ERP components is moderate (P400 and Nc) to substantial (N290). However, there is low test-retest reliability for the effects of the specific experimental manipulations (i.e. emotion and spatial frequency) on the face-sensitive ERPs. To conclude, in infants the face-sensitive ERP components (i.e. N290, P400 and Nc) show adequate test-retest reliability, but not the effects of emotion and spatial frequency on these ERP components. We propose that further research focuses on investigating elements that might increase the test-retest reliability, as adequate test-retest reliability is necessary to draw meaningful conclusions on individual developmental trajectories of the face-sensitive ERPs in infants. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...

Application of Pilates principles increases paraspinal muscle activation.

PubMed

Andrade, Letícia Souza; Mochizuki, Luís; Pires, Flávio Oliveira; da Silva, Renato André Sousa; Mota, Yomara Lima

2015-01-01

To analyze the effect of Pilates principles on the EMG activity of abdominal and paraspinal muscles on stable and unstable surfaces. Surface EMG data about the rectus abdominis (RA), iliocostalis (IL) and lumbar multifidus (MU) of 19 participants were collected while performing three repetitions of a crunch exercise in the following conditions: 1) with no Pilates technique and stable surface (nP + S); 2) with no Pilates technique and unstable surface (nP + U); 3) with Pilates technique and stable surface (P + S); 4) with Pilates and unstable surface (P + U). The EMG Fanalysis was conducted using a custom-made Matlab(®) 10. There was no condition effect in the RA iEMG with stable and unstable surfaces (F(1,290) = 0 p = 0.98) and with and without principles (F(1,290) = 1.2 p = 0.27). IL iEMG was higher for the stable surface condition (F(1,290) = 32.3 p < 0.001) with Pilates principles (F(1,290) = 21.9 p < 0.001). The MU iEMG was higher for the stable surface condition with and without Pilates principles (F(1,290) = 84.9 p < 0.001). Copyright © 2014 Elsevier Ltd. All rights reserved.

ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density.

PubMed

Dahan, Albert; Dunne, Ann; Swartjes, Maarten; Proto, Paolo L; Heij, Lara; Vogels, Oscar; van Velzen, Monique; Sarton, Elise; Niesters, Marieke; Tannemaat, Martijn R; Cerami, Anthony; Brines, Michael

2013-11-08

Small nerve fiber loss and damage (SNFLD) is a frequent complication of sarcoidosis that is associated with autonomic dysfunction and sensory abnormalities, including pain syndromes that severely degrade the quality of life. SNFLD is hypothesized to arise from the effects of immune dysregulation, an essential feature of sarcoidosis, on the peripheral and central nervous systems. Current therapy of sarcoidosis-associated SNFLD consists primarily of immune suppression and symptomatic treatment; however, this treatment is typically unsatisfactory. ARA 290 is a small peptide engineered to activate the innate repair receptor that antagonizes inflammatory processes and stimulates tissue repair. Here we show in a blinded, placebo-controlled trial that 28 d of daily subcutaneous administration of ARA 290 in a group of patients with documented SNFLD significantly improves neuropathic symptoms. In addition to improved patient-reported symptom-based outcomes, ARA 290 administration was also associated with a significant increase in corneal small nerve fiber density, changes in cutaneous temperature sensitivity, and an increased exercise capacity as assessed by the 6-minute walk test. On the basis of these results and of prior studies, ARA 290 is a potential disease-modifying agent for treatment of sarcoidosis-associated SNFLD.

ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Increases Corneal Nerve Fiber Density

PubMed Central

Dahan, Albert; Dunne, Ann; Swartjes, Maarten; Proto, Paolo L; Heij, Lara; Vogels, Oscar; van Velzen, Monique; Sarton, Elise; Niesters, Marieke; Tannemaat, Martijn R; Cerami, Anthony; Brines, Michael

2013-01-01

Small nerve fiber loss and damage (SNFLD) is a frequent complication of sarcoidosis that is associated with autonomic dysfunction and sensory abnormalities, including pain syndromes that severely degrade the quality of life. SNFLD is hypothesized to arise from the effects of immune dysregulation, an essential feature of sarcoidosis, on the peripheral and central nervous systems. Current therapy of sarcoidosis-associated SNFLD consists primarily of immune suppression and symptomatic treatment; however, this treatment is typically unsatisfactory. ARA 290 is a small peptide engineered to activate the innate repair receptor that antagonizes inflammatory processes and stimulates tissue repair. Here we show in a blinded, placebo-controlled trial that 28 d of daily subcutaneous administration of ARA 290 in a group of patients with documented SNFLD significantly improves neuropathic symptoms. In addition to improved patient-reported symptom-based outcomes, ARA 290 administration was also associated with a significant increase in corneal small nerve fiber density, changes in cutaneous temperature sensitivity, and an increased exercise capacity as assessed by the 6-minute walk test. On the basis of these results and of prior studies, ARA 290 is a potential disease-modifying agent for treatment of sarcoidosis-associated SNFLD. PMID:24136731

Multielement analysis of interplanetary dust particles using TOF-SIMS

NASA Technical Reports Server (NTRS)

Stephan, T.; Kloeck, W.; Jessberger, E. K.; Rulle, H.; Zehnpfenning, J.

1993-01-01

Sections of three stratospheric particles (U2015G1, W7029*A27, and L2005P9) were analyzed with TOF-SIMS (Time Of Flight-Secondary Ion Mass Spectrometry) continuing our efforts to investigate the element distribution in interplanetary dust particles (IDP's) with high lateral resolution (approximately 0.2 micron), to examine possible atmospheric contamination effects, and to further explore the abilities of this technique for element analysis of small samples. The samples, previously investigated with SXRF (synchrotron X-ray fluorescence analysis), are highly enriched in Br (Br/Fe: 59 x CI, 9.2 x CI, and 116 x CI, respectively). U2015G1 is the IDP with the by far highest Zn/Fe-ratio (81 x CI) ever reported in chondritic particles.

24 CFR 290.33 - Sale of delinquent mortgages securing subsidized projects.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.33 Sale of...

24 CFR 290.33 - Sale of delinquent mortgages securing subsidized projects.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.33 Sale of...

24 CFR 290.31 - Sale of current mortgages securing subsidized projects.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.31 Sale of current...

24 CFR 290.31 - Sale of current mortgages securing subsidized projects.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.31 Sale of current...

24 CFR 290.31 - Sale of current mortgages securing subsidized projects.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.31 Sale of current...

24 CFR 290.33 - Sale of delinquent mortgages securing subsidized projects.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.33 Sale of...

24 CFR 290.33 - Sale of delinquent mortgages securing subsidized projects.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.33 Sale of...

24 CFR 290.31 - Sale of current mortgages securing subsidized projects.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.31 Sale of current...

Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives.

PubMed

Zanella, Aline Margioti; Nakazone, Marcelo Arruda; Pinhel, Marcela Augusta Souza; Souza, Dorotéia Rossi Silva

2011-03-01

To evaluate whether lipid profile (LP), apolipoprotein A-1 (apo A-I) and malondialdehyde (MDA) have any relationship with physical exercise by comparing the groups of footballers (FG) with sedentary individuals (CG) and their relatives (RFG and RCG). Twenty individuals from FG and CG, 60 from RFG, and 57 from RCG were studied. FG showed lower levels of total cholesterol (119.5 ± 37.9 mg/dL), LDL-cholesterol fraction (53.6 ± 30.3), apo A-I (116.7 ± 11.9), and higher level of HDL-cholesterol fraction (HDLc) (49.7 ± 8.5) compared to RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; and 42.7 ± 7.7, P < 0.01; respectively). Moreover, FG had reduced levels of MDA (101.0 ± 77.0 ng/mL) compared to CG (290.0 ± 341.0, P = 0.03) and RFG (209.9 ± 197.5, P = 0.04). These results suggest an association between physical exercise and lower levels of MDA in FG. Physical activity seems to promote beneficial effects on the LP regardless of the genetic influence considering HDLc levels.

A Methodology to Measure the Cost of a Single Outpatient Visit in the Family Practice Clinic

DTIC Science & Technology

1986-07-01

17,598 EDEA Other Base Support 116 " i 25,480 453 EDCA Maint Real Prop 116 Is 25,480 4,652 EDDA Minor Const 116 " H 25,480 460 EDFA Leases/Rentals 116...Engineer Liaison 116 22,319 177 EDBA Utilities 116 " " 22,319 15,414 EDEA Other Base Support 116 " " 22,319 398 EDCA Maint Real Prop 116 22,319 4,075 EDDA ...Liaison 116 4,301 34 EDBA Utilities 116 " " 4,301 2,970 EDEA Other Base Support 116 " " 4,301 76 EDCA Maint Real Prop 116 " " 4,301 785 EDDA Minor Const 116

Financial Relationships between Organizations That Produce Clinical Practice Guidelines and the Biomedical Industry: A Cross-Sectional Study

PubMed Central

Campsall, Paul; Colizza, Kate; Straus, Sharon; Stelfox, Henry T.

2016-01-01

Background Financial relationships between organizations that produce clinical practice guidelines and biomedical companies are vulnerable to conflicts of interest. We sought to determine whether organizations that produce clinical practice guidelines have financial relationships with biomedical companies and whether there are associations between organizations’ conflict of interest policies and recommendations and disclosures provided in guidelines. Methods and Findings We conducted a cross-sectional survey and review of websites of 95 national/international medical organizations that produced 290 clinical practice guidelines published on the National Guideline Clearinghouse website from January 1 to December 31, 2012. Survey responses were available for 68% (65/95) of organizations (167/290 guidelines, 58%), and websites were reviewed for 100% (95/95) of organizations (290/290 guidelines, 100%). In all, 63% (60/95) of organizations producing clinical practice guidelines reported receiving funds from a biomedical company; 80% (76/95) of organizations reported having a policy for managing conflicts of interest. Disclosure statements (disclosing presence or absence of financial relationships with biomedical companies) were available in 65% (188/290) of clinical practice guidelines for direct funding sources to produce the guideline, 51% (147/290) for financial relationships of the guideline committee members, and 1% (4/290) for financial relationships of the organizations producing the guidelines. Among all guidelines, 6% (18/290) disclosed direct funding by biomedical companies, 40% (117/290) disclosed financial relationships between committee members and biomedical companies (38% of guideline committee members, 773/2,043), and 1% (4/290) disclosed financial relationships between the organizations producing the guidelines and biomedical companies. In the survey responses, 60 organizations reported the procedures that they included in their conflict of interest policies (158 guidelines): guidelines produced by organizations reporting more comprehensive conflict of interest policies (per additional procedure, range 5–17) included fewer positive (rate ratio [RR] 0.91, 95% CI 0.86–0.95) and more negative (RR 1.32, 95% CI 1.09–1.60) recommendations regarding patented biomedical products. The clinical practice guidelines produced by organizations reporting more comprehensive conflict of interest policies were also more likely to include disclosure statements for direct funding sources (odds ratio [OR] 1.31, 95% CI 1.10–1.56) and financial relationships of guideline committee members (OR 1.36, 95% CI 1.09–1.79), but not financial relationships of the organizations (0 disclosures). Limitations of the study include the use of the National Guideline Clearinghouse as the single source of clinical practice guidelines and the self-report of survey responses and organizations’ website postings. Conclusions Financial relationships between organizations that produce clinical practice guidelines and biomedical companies are common and infrequently disclosed in guidelines. Our study highlights the need for an effective policy to manage organizational conflicts of interest and disclosure of financial relationships. PMID:27244653

Leber Congenital Amaurosis Associated with Mutations in CEP290, Clinical Phenotype, and Natural History in Preparation for Trials of Novel Therapies.

PubMed

Sheck, Leo; Davies, Wayne I L; Moradi, Phillip; Robson, Anthony G; Kumaran, Neruban; Liasis, Alki C; Webster, Andrew R; Moore, Anthony T; Michaelides, Michel

2018-06-01

To investigate and describe in detail the demographics, functional and anatomic characteristics, and clinical course of Leber congenital amaurosis (LCA) associated with mutations in the CEP290 gene (LCA-CEP290) in a large cohort of adults and children. Retrospective case series. Patients with mutations in CEP290 identified at a single UK referral center. Review of case notes and results of retinal imaging (color fundus photography, fundus autofluorescence [FAF] imaging, OCT), electrophysiologic assessment, and molecular genetic testing. Molecular genetic testing, clinical findings including visual acuity and retinal imaging, and electrophysiologic assessment. Forty patients with LCA-CEP290 were identified. The deep intronic mutation c.2991+1655 A>G was the most common disease-causing variant (23/40 patients) identified in the compound heterozygous state in 20 patients (50%) and homozygous in 2 patients (5%). Visual acuity (VA) varied from 6/9 to no perception of light, and only 2 of 12 patients with longitudinal VA data showed deterioration in VA in their better-seeing eye over time. A normal fundus was found at diagnosis in younger patients (mean age, 1.9 years), with older patients showing white flecks (mean age, 5.9 years) or pigmentary retinopathy (mean age, 21.7 years). Eleven of 12 patients (92%) with OCT imaging had preservation of foveal architecture. Ten of 12 patients (83%) with FAF imaging had a perifoveal hyperautofluorescent ring. Having 2 nonsense CEP290 mutations was associated with worse final VA and the presence of nonocular features. Detailed analysis of the clinical phenotype of LCA-CEP290 in a large cohort confirms that there is a window of opportunity in childhood for therapeutic intervention based on relative structural preservation in the central cone-rich retina in a significant proportion of patients, with the majority harboring the deep intronic variant potentially tractable to several planned gene editing approaches. Copyright © 2018 American Academy of Ophthalmology. All rights reserved.

Ketamine Does Not Produce Relief of Neuropathic Pain in Mice Lacking the β-Common Receptor (CD131)

PubMed Central

Swartjes, Maarten; Niesters, Marieke; Heij, Lara; Dunne, Ann; Aarts, Leon; Hand, Carla Cerami; Kim, Hyung-Suk; Brines, Michael; Cerami, Anthony; Dahan, Albert

2013-01-01

Neuropathic pain (NP) is a debilitating condition associated with traumatic, metabolic, autoimmune and neurological etiologies. Although the triggers for NP are diverse, there are common underlying pathways, including activation of immune cells in the spinal cord and up-regulation of the N-methyl-D-aspartate receptor (NMDAR). Ketamine, a well-known NDMAR antagonist, reduces neuropathic pain in a sustained manner. Recent study has shown that the novel 11-amino acid peptide erythropoietin derivative ARA290 produces a similar, long-lasting relief of NP. Here, we show that both drugs also have similar effects on the expression of mRNA of the NMDAR, as well as that of microglia, astrocytes and chemokine (C-C motif) ligand 2, all-important contributors to the development of NP. Although the effects of ketamine and ARA 290 on NP and its molecular mediators suggest a common mechanism of action, ARA 290 has no affinity for the NMDAR and acts specifically via the innate repair receptor (IRR) involved in tissue protection. We speculated therefore, that the IRR might be critically involved in the action of ketamine on neuropathic pain. To evaluate this, we studied the effects of ketamine and ARA 290 on acute pain, side effects, and allodynia following a spared nerve injury model in mice lacking the β-common receptor (βcR), a structural component of the IRR. Ketamine (50 mg/kg) and ARA 290 (30 µg/kg) produced divergent effects on acute pain: ketamine produced profound antinociception accompanied with psychomotor side effects, but ARA290 did not, in both normal and knock out mice. In contrast, while both drugs were antiallodynic in WT mice, they had no effect on NP in mice lacking the βcR. Together, these results show that an intact IRR is required for the effective treatment of NP with either ketamine or ARA 290, but is not involved in ketamine’s analgesic and side effects. PMID:23936499

24 CFR 290.35 - Sale of HUD-held mortgages securing unsubsidized projects.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.35 Sale of HUD-held...

24 CFR 290.35 - Sale of HUD-held mortgages securing unsubsidized projects.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.35 Sale of HUD-held...

24 CFR 290.35 - Sale of HUD-held mortgages securing unsubsidized projects.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.35 Sale of HUD-held...

24 CFR 290.35 - Sale of HUD-held mortgages securing unsubsidized projects.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.35 Sale of HUD-held...

Spectral, optical and cytotoxicity studies on 2-isonicotinoyl-N-phenylhydrazine-1-carboxamide(H3L) and some of its metal complexes

NASA Astrophysics Data System (ADS)

Hosny, Nasser M.; Hassan, Nader Y.; Mahmoud, Heba M.; Abdel-Rhman, Mohamed H.

2018-03-01

The ligand 2-isonicotinoyl-N-phenylhydrazine-1-carboxamide (H3L) and its metal complexes with Co(II), Ni(II), Cu(II) and Zn(II) acetates have been synthesized. The isolated compounds have been characterized by elemental analyses, FT-IR, 1H NMR, 13C NMR, ESR, mass, electronic spectra, electrical conductivity, effective magnetic moments and thermal analyses. The free organic ligand exists in the keto form, but in the metal complexes, it coordinates in the enol form. Four coordinated species were suggested for all the isolated metal complexes. The measured optical band gap values confirmed the presence of direct electronic transition and the semi-conductivity of the compounds. The ligand and its Zn(II) complex were examined as cytotoxic agent against HCT-116 and HePG-2. The ligand showed very strong cytotoxic effect against HePG-2, but moderate cytotoxicity against HCT-116. Zn(II) complex showed weak cytotoxicity against the two cell lines.

Thermophysical Properties of Matter - The TPRC Data Series. Volume 4. Specific Heat - Metallic Elements and Alloys

DTIC Science & Technology

1971-01-01

alloys— sodium — sodium alloya— solder—carbon ateels—chromium steels—silicon steels—tantalum—tantalum alloys—terbium—thallium—thallium alloys—thorium...Praseodymium 45 Rhenium 46 Rhodium 47 Rubidium 48 Ruthenium 4» Samarium 50 Scandium 51 Selenium 52 Silicon 5:i Silver 54 Sodium 55 Strontium 56...Potassium ♦ Sodium 111 Sodium * Potassium 112 Tantalum ♦ Tungsten 113 Thallium + Lead, PbTl| 114 Tin ♦ Bismuth 115 Tin ♦ Indium 116 Tin+ Lead 117

Exclusion Area Radiation Release during the MIT Reactor Design Basis Accident.

DTIC Science & Technology

1983-05-06

Concrete Wall 116 6.2 Concrete Albedo Dose 121 6.3 Steel Door Scattering Dose 124 7.1 Total Dose Results 133 A.1 Values of N /NO for Neutron -Capture...plate fuel elements arranged in x a compact hexagonal core. This core design maximizes the neutron flux in the DO2 reflector region where numerous...sec) V = Volume of the fuel (cm 3 f Ef = Macroscopic fission cross section (cm ) = Thermal neutron flux ( neutrons /cm2 - sec) = Core-averaged value Yi

Modern physics - Guest editorial

NASA Astrophysics Data System (ADS)

Howes, Ruth

2000-02-01

What an exciting time to be a physicist! You only have to attend the plenaries at an AAPT meeting to realize just how many mysteries there still are. Will string theory actually prove to be a Theory of Everything? Can we use physics to understand, predict, and perhaps eventually mitigate damaging hurricanes? Is the warming trend of the Earth due to man-made changes in the atmosphere? Have we found the nuclear "island of stability" with elements 114, 116, and 118? For that matter, why is ice slippery?

Iran-Regional Country Study.

DTIC Science & Technology

1982-04-16

AO-A116 226 ARMY WAR COLL CARLISLE BARRACKS PA F/6 5/4 IRAN-REGIONAL C OUNTRY STUDY.IUI UNCLASSIFIED AR8 AE I m I I..h EE f ii111112.0...ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT, PROJECT. TASK AREA & WORK UNIT NUMBERS US Army War College Carlisle Barracks, PA 17013 11. CONTROLLING...PAGE(WIFhIf Date REmfot)J Bi9 US ARMY WAR COLLEGE INDIVIDUAL RESEARCH BASED ESSAY The views xpressed in this paper are those of the author and do not

Application of Artificial Boundary Conditions in Sensitivity-Based Updating of Finite Element Models

DTIC Science & Technology

2007-06-01

is known as the impedance matrix[ ]( )Z Ω . [ ] [ ] 1( ) ( )Z H −Ω = Ω (12) where [ ] 2( )Z K M j C ⎡ ⎤Ω = −Ω + Ω⎣ ⎦ (13) A. REDUCED ORDER...D.L. A correlation coefficient for modal vector analysis. Proceedings of 1st International Modal Analysis Conference, 1982, 110-116. Anton , H ... Rorres , C ., (2005). Elementary Linear Algebra. New York: John Wiley and Sons. Avitable, Peter (2001, January) Experimental Modal Analysis, A Simple

Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns

PubMed Central

Bohr, Stefan; Patel, Suraj J.; Shen, Keyue; Vitalo, Antonia G.; Brines, Michael; Cerami, Anthony; Berthiaume, Francois; Yarmush, Martin L.

2013-01-01

Alternate erythropoietin (EPO)–mediated signaling via the heteromeric receptor composed of the EPO receptor and the β-common receptor (CD131) exerts the tissue-protective actions of EPO in various types of injuries. Herein we investigated the effects of the EPO derivative helix beta surface peptide (synonym: ARA290), which specifically triggers alternate EPO-mediated signaling, but does not bind the erythropoietic EPO receptor homodimer, on the progression of secondary tissue damage following cutaneous burns. For this purpose, a deep partial thickness cutaneous burn injury was applied on the back of mice, followed by systemic administration of vehicle or ARA290 at 1, 12, and 24 h postburn. With vehicle-only treatment, wounds exhibited secondary microvascular thrombosis within 24 h postburn, and subsequent necrosis of the surrounding tissue, thus converting to a full-thickness injury within 48 h. On the other hand, when ARA290 was systemically administered, patency of the microvasculature was maintained. Furthermore, ARA290 mitigated the innate inflammatory response, most notably tumor necrosis factor-alpha–mediated signaling. These findings correlated with long-term recovery of initially injured yet viable tissue components. In conclusion, ARA290 may be a promising therapeutic approach to prevent the conversion of partial- to full-thickness burn injuries. In a clinical setting, the decrease in burn depth and area would likely reduce the necessity for extensive surgical debridement as well as secondary wound closure by means of skin grafting. This use of ARA290 is consistent with its tissue-protective properties previously reported in other models of injury, such as myocardial infarction and hemorrhagic shock. PMID:23401545

Gallium arsenide quantum well-based far infrared array radiometric imager

NASA Technical Reports Server (NTRS)

Forrest, Kathrine A.; Jhabvala, Murzy D.

1991-01-01

We have built an array-based camera (FIRARI) for thermal imaging (lambda = 8 to 12 microns). FIRARI uses a square format 128 by 128 element array of aluminum gallium arsenide quantum well detectors that are indium bump bonded to a high capacity silicon multiplexer. The quantum well detectors offer good responsivity along with high response and noise uniformity, resulting in excellent thermal images without compensation for variation in pixel response. A noise equivalent temperature difference of 0.02 K at a scene temperature of 290 K was achieved with the array operating at 60 K. FIRARI demonstrated that AlGaAS quantum well detector technology can provide large format arrays with performance superior to mercury cadmium telluride at far less cost.

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2013 CFR

2013-04-01

... loan restructuring or final compromise of the mortgage debt and shall include a covenant in any... defined in § 290.3. (2) This requirement shall continue in effect until the mortgage debt is satisfied. (d...

Effect of ultraviolet radiation, smoking and nutrition on hair.

PubMed

Trüeb, Ralph M

2015-01-01

Similar to the rest of the skin, the hair is exposed to noxious environmental factors. While ultraviolet radiation (UVR) and smoking are well appreciated as major factors contributing to the extrinsic aging of the skin, their effects on the condition of hair have only lately attracted the attention of the medical community. Terrestrial solar UVR ranges from approximately 290 to 400 nm; UV-B (290-315 nm) reaches only the upper dermis, while the penetration of UV-A (315-400 nm) into the dermis increases with wavelength. The two most important chronic effects of UVR on the skin and bald scalp are photocarcinogenesis and solar elastosis; however, the effects of UVR on hair have largely been ignored. As a consequence of increased leisure time and a growing popularity of outdoor activities and holidays in the sun, the awareness of sun protection of the skin has become important and should also apply to the hair. Besides being the single-most preventable cause of significant cardiovascular and pulmonary morbidity and an important cause of death, the association of tobacco smoking with various adverse effects on the skin and hair has also been recognized. Increasing public awareness of the association between smoking and hair loss seems to offer a good opportunity for the prevention or cessation of smoking, since the appearance of hair plays an important role in the overall physical appearance and self-perception of people. Finally, the quantity and quality of hair are closely related to the nutritional state of an individual. Normal supply, uptake, and transport of proteins, calories, trace elements, and vitamins are of fundamental importance in tissues with high biosynthetic activity, such as the hair follicle. In instances of protein and calorie malnutrition as well as essential amino acid, trace element, and vitamin deficiencies, hair growth and pigmentation may be impaired. Ultimately, important commercial interest lies in the question of whether increasing the content of an already adequate diet with specific amino acids, vitamins and/or trace elements may further promote hair growth. Unless the hair is impaired due to nutritional deficiency, there is only so much that nutrients can do to increase the size of individual hairs because hair thickness is largely genetic. Nevertheless, there are external factors that influence hair health to such a degree that micronutrients could boost hair that is suffering from these problems. © 2015 S. Karger AG, Basel.

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., HUD acquires a project. (c) Methods of notification—(1) To tenants. Pre-disposition notification will... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

15 CFR 290.5 - Basic proposal qualifications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.5 Basic proposal qualifications. (a) NIST shall... emphasis on areas consistent with NIST technology research programs and organizational expertise. (viii) A...

15 CFR 290.5 - Basic proposal qualifications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.5 Basic proposal qualifications. (a) NIST shall... emphasis on areas consistent with NIST technology research programs and organizational expertise. (viii) A...

15 CFR 290.5 - Basic proposal qualifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.5 Basic proposal qualifications. (a) NIST shall... emphasis on areas consistent with NIST technology research programs and organizational expertise. (viii) A...

15 CFR 290.5 - Basic proposal qualifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.5 Basic proposal qualifications. (a) NIST shall... emphasis on areas consistent with NIST technology research programs and organizational expertise. (viii) A...

32 CFR 706.2 - Certifications of the Secretary of the Navy under Executive Order 11964 and 33 U.S.C. 1605.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 774 2.9 USS TEXAS SSN 775 2.90 USS HAWAII SSN 776 2.90 USS NORTH CAROLINA SSN 777 2.90 USS NEW....1 below USS TORNADO PC 14 1 27.8 3.01 1.1 below USS DOLPHIN AGSS 555 227.51/2 1191/2 1911/2 2.1 10.8... SSN 773 209° 4.4 6.1 3.4 1.7 below USS VIRGINIA SSN 774 205° 4.37 11.05 2.8 0.30 below USS TEXAS SSN...

Select Components and Finish System Design of a Window Air Conditioner with Propane

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, Bo; Abdelaziz, Omar

This report describes the technical targets for developing a high efficiency window air conditioner (WAC) using propane (R-290). The baseline unit selected for this activity is a GE R-410A WAC. We established collaboration with a Chinese rotary compressor manufacturer, to select an R-290 compressor. We first modelled and calibrated the WAC system model using R-410A. Next, we applied the calibrated system model to design the R-290 WAC, and decided the strategies to reduce the system charge below 260 grams and achieve the capacity and efficiency targets.

Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis.

PubMed

Drivas, Theodore G; Wojno, Adam P; Tucker, Budd A; Stone, Edwin M; Bennett, Jean

2015-06-10

Genetic pleiotropy, the phenomenon by which mutations in the same gene result in markedly different disease phenotypes, has proven difficult to explain with traditional models of disease pathogenesis. We have developed a model of pleiotropic disease that explains, through the process of basal exon skipping, how different mutations in the same gene can differentially affect protein production, with the total amount of protein produced correlating with disease severity. Mutations in the centrosomal protein of 290 kDa (CEP290) gene are associated with a spectrum of phenotypically distinct human diseases (the ciliopathies). Molecular biologic examination of CEP290 transcript and protein expression in cells from patients carrying CEP290 mutations, measured by quantitative polymerase chain reaction and Western blotting, correlated with disease severity and corroborated our model. We show that basal exon skipping may be the mechanism underlying the disease pleiotropy caused by CEP290 mutations. Applying our model to a different disease gene, CC2D2A (coiled-coil and C2 domains-containing protein 2A), we found that the same correlations held true. Our model explains the phenotypic diversity of two different inherited ciliopathies and may establish a new model for the pathogenesis of other pleiotropic human diseases. Copyright © 2015, American Association for the Advancement of Science.

Development of technology for modeling of a 1/8-scale dynamic model of the shuttle Solid Rocket Booster (SRB)

NASA Technical Reports Server (NTRS)

Levy, A.; Zalesak, J.; Bernstein, M.; Mason, P. W.

1974-01-01

A NASTRAN analysis of the solid rocket booster (SRB) substructure of the space shuttle 1/8-scale structural dynamics model. The NASTRAN finite element modeling capability was first used to formulate a model of a cylinder 10 in. radius by a 200 in. length to investigate the accuracy and adequacy of the proposed grid point spacing. Results were compared with a shell analysis and demonstrated relatively accurate results for NASTRAN for the lower modes, which were of primary interest. A finite element model of the full SRB was then formed using CQUAD2 plate elements containing membrane and bending stiffness and CBAR offset bar elements to represent the longerons and frames. Three layers of three-dimensional CHEXAI elements were used to model the propellant. This model, consisting of 4000 degrees of freedom (DOF) initially, was reduced to 176 DOF using Guyan reduction. The model was then submitted for complex Eigenvalue analysis. After experiencing considerable difficulty with attempts to run the complete model, it was split into two substructres. These were run separately and combined into a single 116 degree of freedom A set which was successfully run. Results are reported.

Determination of elements in hospital waste with neutron activation analysis method

NASA Astrophysics Data System (ADS)

Dwijananti, P.; Astuti, B.; Alwiyah; Fianti

2018-03-01

The producer of the biggest B3 waste is hospital. The waste is from medical and laboratory activities. The purpose of this study is to determine the elements contained in the liquid waste from hospital and calculate the levels of these elements. This research was done by analysis of the neutron activation conducted at BATAN Yogyakarta. The neutron activation analysis is divided into two stages: activation of the samples using neutron sources of reactor Kartini, then chopping by using a set of tools, gamma spectrometer with HPGe detector. Qualitative and quantitative analysis were done by matching the gamma spectrum peak to the Neutron Activation Table. The sample was taken from four points of the liquid waste treatment plant (WWTP) Bhakti Wira Tamtama Semarang hospital. The results showed that the samples containing elements of Cr, Zn, Fe, Co, and Na, with the levels of each element is Cr (0.033 - 0.075) mg/L, Zn (0.090 - 1.048) mg/L, Fe (2.937-37.743) mg/L, Co (0.005-0.023) mg/L, and Na (61.088-116.330) mg/L. Comparing to the standard value, the liquid is safe to the environment.

15 CFR 290.5 - Basic proposal qualifications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.5 Basic proposal qualifications. (a) NIST shall... with any invention or copyright which may result from the involvement in the Center's technology...

1,000-Ship Navy: New Concept or Current SOUTHCOM Maritime SOP

DTIC Science & Technology

2007-05-10

and delivered over 3.9 million dollars in parts and supplies.22 This 20 USCGC GENTIAN ( WIX 290...at the “West2007, AFCEA/Naval Institute Conference”, San Diego, CA, 9 February 2007 . USCGC GENTIAN ( WIX 290) Caribbean Support Tender

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-04-01

... respect to the disposition of multifamily projects under subpart A, HUD may follow any other method of... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2011 CFR

2011-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.3 Program description. (a) The Secretary, acting through the... for the Transfer of Manufacturing Technology. Each Center shall be affiliated with a U.S.-based...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.3 Program description. (a) The Secretary, acting through the... for the Transfer of Manufacturing Technology. Each Center shall be affiliated with a U.S.-based...

Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290

PubMed Central

Kaftanovskaya, Elena M.; Soula, Mariluz; Myhr, Courtney; Ho, Brian A.; Moore, Stefanie N.; Yoo, Changwon; Cervantes, Briana; How, Javier; Marugan, Juan; Agoulnik, Irina U.

2017-01-01

Relaxin, a small peptide hormone of the insulin/relaxin family, demonstrated antifibrotic, organ protective, vasodilatory, and proangiogenic properties in clinical trials and several animal models of human diseases. Relaxin family peptide receptor 1 (RXFP1) is the relaxin cognate G protein-coupled receptor. We have identified a series of small molecule agonists of human RXFP1. The lead compound ML290 demonstrated preferred absorption, distribution, metabolism, and excretion profiles, is easy to synthesize, and has high stability in vivo. However, ML290 does not activate rodent RXFP1s and therefore cannot be tested in common preclinical animal models. Here we describe the production and analysis of a mouse transgenic model, a knock-out/knock-in of the human RXFP1 (hRXFP1) complementary DNA into the mouse Rxfp1 (mRxfp1) gene. Insertion of the vector into the mRxfp1 locus caused disruption of mRxfp1 and expression of hRXFP1. The transcriptional expression pattern of the hRXFP1 allele was similar to mRxfp1. Female mice homozygous for hRXFP1 showed relaxation of the pubic symphysis at parturition and normal development of mammary nipples and vaginal epithelium, indicating full complementation of mRxfp1 gene ablation. Intravenous injection of relaxin led to an increase in heart rate in humanized and wild-type females but not in Rxfp1-deficient mice, whereas ML290 increased heart rate in humanized but not wild-type animals, suggesting specific target engagement by ML290. Moreover, intraperitoneal injection of ML290 caused a decrease in blood osmolality. Taken together, our data show humanized RXFP1 mice can be used for testing relaxin receptor modulators in various preclinical studies. PMID:28825052

Growth characteristics of Lactobacillus brevis KB290 in the presence of bile.

PubMed

Kimoto-Nira, Hiromi; Suzuki, Shigenori; Suganuma, Hiroyuki; Moriya, Naoko; Suzuki, Chise

2015-10-01

Live Lactobacillus brevis KB290 have several probiotic activities, including immune stimulation and modulation of intestinal microbial balance. We investigated the adaptation of L. brevis KB290 to bile as a mechanism of intestinal survival. Strain KB290 was grown for 5 days at 37 °C in tryptone-yeast extract-glucose (TYG) broth supplemented with 0.5% sodium acetate (TYGA) containing 0.15%, 0.3%, or 0.5% bile. Growth was determined by absorbance at 620 nm or by dry weight. Growth was enhanced as the broth's bile concentration increased. Bile-enhanced growth was not observed in TYG broth or with xylose or fructose as the carbon source, although strain KB290 could assimilate these sugars. Compared with cells grown without bile, cells grown with bile had twice the cell yield (dry weight) and higher hydrophobicity, which may improve epithelial adhesion. Metabolite analysis revealed that bile induced more lactate production by glycolysis, thus enhancing growth efficiency. Scanning electron microscopy revealed that cells cultured without bile for 5 days in TYGA broth had a shortened rod shape and showed lysis and aggregation, unlike cells cultured for 1 day; cells grown with bile for 5 days had an intact rod shape and rarely appeared damaged. Cellular material leakage through autolysis was lower in the presence of bile than in its absence. Thus lysis of strain KB290 cells cultured for extended periods was suppressed in the presence of bile. This study provides new role of bile and sodium acetate for retaining an intact cell shape and enhancing cell yield, which are beneficial for intestinal survival. Copyright © 2015 Elsevier Ltd. All rights reserved.

Importance of the residue Asp 290 on chain length selectivity and catalytic efficiency of recombinant Staphylococcus simulans lipase expressed in E. coli.

PubMed

Sayari, Adel; Mosbah, Habib; Gargouri, Youssef

2007-05-01

In addition to their physiological importance, microbial lipases, like staphylococcal ones, are of considerable commercial interest for biotechnological applications such as detergents, food production, and pharmaceuticals and industrial synthesis of fine chemicals. The gene encoding the extracellular lipase of Staphylococcus simulans (SSL) was subcloned in the pET-14b expression vector and expressed in Esherichia coli BL21 (DE3). The wild-type SSL was expressed as amino terminal His6-tagged recombinant protein. One-step purification of the recombinant lipase was achieved with nickel metal affinity column. The purified His-tagged SSL (His6-SSL) is able to hydrolyse triacylglycerols without chain length selectivity. The major differences among lipases are reflected in their chemical specificity in the hydrolysis of peculiar ester bonds, and their respective capacity to hydrolyse substrates having different physico-chemical properties. It has been proposed, using homology alignment, that the region around the residue 290 of Staphylococcus hyicus lipase could be involved in the selection of the substrate. To evaluate the importance of this environment, the residue Asp290 of Staphylococcus simulans lipase was mutated to Ala using site-directed mutagenesis. The mutant expression plasmid was also overexpressed in Esherichia coli and purified with a nickel metal affinity column. The substitution of Asp290 by Ala was accompanied by a significant shift of the acyl-chain length specificity of the mutant towards short chain fatty acid esters. Kinetic studies of wild-type SSL and its mutant D290A were carried out, and show essentially that the catalytic efficiency (k cat /K M ) of the mutant was affected. Our results confirmed that Asp290 is important for the chain length selectivity and catalytic efficiency of Staphylococcus simulans lipase.

Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.

PubMed

Barny, Iris; Perrault, Isabelle; Michel, Christel; Soussan, Mickael; Goudin, Nicolas; Rio, Marlène; Thomas, Sophie; Attié-Bitach, Tania; Hamel, Christian; Dollfus, Hélène; Kaplan, Josseline; Rozet, Jean-Michel; Gerard, Xavier

2018-05-16

CEP290 mutations cause a spectrum of ciliopathies from Leber congenital amaurosis type 10 (LCA10) to embryo-lethal Meckel syndrome (MKS). Using panel-based molecular diagnosis testing for inherited retinal diseases, we identified two individuals with some preserved vision despite biallelism for presumably truncating CEP290 mutations. The first one carried a homozygous 1 base-pair deletion in exon 17, introducing a premature termination codon (PTC) in exon 18 (c.1666del; p.Ile556Phefs*17). mRNA analysis revealed a basal exon skipping (BES) of exon 18, providing mutant cells with the ability to escape protein truncation, while disrupting the reading frame in controls. The second individual harbored compound heterozygous nonsense mutations in exon 8 (c.508A>T, p.Lys170*) and exon 32 (c.4090G>T, p.Glu1364*), respectively. Some CEP290 lacking exon 8 were detected in mutant fibroblasts but not in controls whereas some skipping of exon 32 occurred in both lines, but with higher amplitude in the mutant. Considering that the deletion of either exon maintains the reading frame in either line, skipping in mutant cells likely involves nonsense-associated altered splicing (NAS) alone (exon 8), or with BES (exon 32). Skipping of PTC-containing exons in mutant cells allowed production of CEP290 isoforms with preserved ability to assemble into a high molecular weight complex and to interact efficiently with proteins important for cilia formation and intraflagellar trafficking. In contrast, studying LCA10 and MKS fibroblasts we show moderate to severe cilia alterations, providing support for a correlation between disease severity and the ability of cells to express shortened, yet functional, CEP290 isoforms.

Buckling Testing and Analysis of Honeycomb Sandwich Panel Arc Segments of a Full-Scale Fairing Barrel. Part 3; 8-ply Out-of-Autoclave Facesheets

NASA Technical Reports Server (NTRS)

Pineda, Evan J.; Myers, David E.; Kosareo, Daniel N.; Kellas, Sotiris

2014-01-01

Four honeycomb sandwich panels, representing 1/16th arc segments of a 10 m diameter barrel section of the heavy lift launch vehicle, were manufactured under the NASA Composites for Exploration program and the NASA Constellation Ares V program. Two configurations were chosen for the panels: 6-ply facesheets with 1.125 in. honeycomb core and 8-ply facesheets with 1.000 in. honeycomb core. Additionally, two separate carbon fiber/epoxy material systems were chosen for the facesheets: inautoclave IM7/977-3 and out-of-autoclave T40-800B/5320-1. Smaller 3- by 5-ft panels were cut from the 1/16th barrel sections. These panels were tested under compressive loading at the NASA Langley Research Center. Furthermore, linear eigenvalue and geometrically nonlinear finite element analyses were performed to predict the compressive response of the 3- by 5-ft panels. This manuscript summarizes the experimental and analytical modeling efforts pertaining to the panel composed of 8-ply, T40-800B/5320-1 facesheets (referred to as Panel C). To improve the robustness of the geometrically nonlinear finite element model, measured surface imperfections were included in the geometry of the model. Both the linear and nonlinear, two-dimensional (2-D) and three-dimensional (3-D), models yield good qualitative and quantitative predictions. Additionally, it was predicted correctly that the panel would fail in buckling prior to failing in strength.

The role of Ia molecules in the activation of T lymphocytes. I. The activation of an IL 1-dependent IL 2-producing T cell hybridoma by Con A requires an interaction, which is not H-2-restricted, with an Ia-bearing accessory cell.

PubMed

Rock, K L

1982-10-01

A model of accessory cell-dependent lectin-mediated T cell activation was investigated by utilizing a mitogen-inducible T cell hybridoma. A continuous MHC-restricted antigen-specific T cell line was fused with the azaguanine-resistant AKR thymoma BW5147. A hybrid, RF1.16B, was identified that is minimally inducible by Con A stimulation alone but is stimulated by Con A in the presence of T cell-depleted accessory cells to produce interleukin 2. The accessory cell function can be replaced by the monokine interleukin 1. Thus the lectin is a sufficient trigger for the hybrid in the absence of MHC restriction elements. The accessory cell function from splenocytes is provided by a non-B, non-T, predominantly Ia-bearing radioresistant cell. The interaction between the RF1.16B hybrid and the accessory cell population is not H-2-restricted. Control experiments, including the use of a cloned source of accessory cells, ruled out contaminating T cells or direct lectin effects as an explanation for the lack of H-2 restriction. The finding that an Ia-bearing cell is required for activation in an MHC-nonrestricted manner is discussed, and a hypothesis is raised that Ia antigens may play a role in addition to that of being a restriction element.

24 CFR 290.15 - Disposition plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.15 Disposition plan. (a) In general. Before disposing of a HUD-owned multifamily housing project, HUD will develop an initial and a final disposition plan...

24 CFR 290.15 - Disposition plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.15 Disposition plan. (a) In general. Before disposing of a HUD-owned multifamily housing project, HUD will develop an initial and a final disposition plan...

24 CFR 290.15 - Disposition plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.15 Disposition plan. (a) In general. Before disposing of a HUD-owned multifamily housing project, HUD will develop an initial and a final disposition plan...

21 CFR 556.290 - Furazolidone.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD Specific Tolerances for Residues of New Animal Drugs § 556.290 Furazolidone. A tolerance of zero is established for residues of...

47 CFR 80.290 - Auxiliary receiving antenna.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not available...

47 CFR 80.290 - Auxiliary receiving antenna.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not available...

47 CFR 80.290 - Auxiliary receiving antenna.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not available...

47 CFR 80.290 - Auxiliary receiving antenna.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not available...

47 CFR 80.290 - Auxiliary receiving antenna.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Auxiliary receiving antenna. 80.290 Section 80... antenna. An auxiliary receiving antenna must be provided when necessary to avoid unauthorized interruption or reduced efficiency of the required watch because the normal receiving antenna is not available...

Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles

PubMed Central

Zhang, Jinsong; Taylor, Ethan W; Wan, Xiaochun; Peng, Dungeng

2012-01-01

Background Elemental selenium nanoparticles have emerged as a novel selenium source with the advantage of reduced risk of selenium toxicity. The present work investigated whether heat treatment affects the size, structure, and bioactivity of selenium nanoparticles. Methods and results After a one-hour incubation of solution containing 80 nm selenium particles in a 90°C water bath, the nanoparticles aggregated into larger 110 nm particles and nanorods (290 nm × 70 nm), leading to significantly reduced bioavailability and phase II enzyme induction in selenium-deficient mice. When a solution containing 40 nm selenium nanoparticles was treated under the same conditions, the nanoparticles aggregated into larger 72 nm particles but did not transform into nanorods, demonstrating that the thermostability of selenium nanoparticles is size-dependent, smaller selenium nanoparticles being more resistant than larger selenium nanoparticles to transformation into nanorods during heat treatment. Conclusion The present results suggest that temperature and duration of the heat process, as well as the original nanoparticle size, should be carefully selected when a solution containing selenium nanoparticles is added to functional foods. PMID:22359458

Systematic prediction of control proteins and their DNA binding sites

PubMed Central

Sorokin, Valeriy; Severinov, Konstantin; Gelfand, Mikhail S.

2009-01-01

We present here the results of a systematic bioinformatics analysis of control (C) proteins, a class of DNA-binding regulators that control time-delayed transcription of their own genes as well as restriction endonuclease genes in many type II restriction-modification systems. More than 290 C protein homologs were identified and DNA-binding sites for ∼70% of new and previously known C proteins were predicted by a combination of phylogenetic footprinting and motif searches in DNA upstream of C protein genes. Additional analysis revealed that a large proportion of C protein genes are translated from leaderless RNA, which may contribute to time-delayed nature of genetic switches operated by these proteins. Analysis of genetic contexts of newly identified C protein genes revealed that they are not exclusively associated with restriction-modification genes; numerous instances of associations with genes originating from mobile genetic elements were observed. These instances might be vestiges of ancient horizontal transfers and indicate that during evolution ancestral restriction-modification system genes were the sites of mobile elements insertions. PMID:19056824

21 CFR 1271.290 - Tracking.

Code of Federal Regulations, 2010 CFR

2010-04-01

... TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.290 Tracking. (a) General. If you perform any... designed to facilitate effective tracking, using the distinct identification code, from the donor to the... for recording the distinct identification code and type of each HCT/P distributed to a consignee to...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the requirements of 12 U.S.C. 1701z-11 for the management and disposition of multifamily housing projects and the...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the requirements of 12 U.S.C. 1701z-11 for the management and disposition of multifamily housing projects and the...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the requirements of 12 U.S.C. 1701z-11 for the management and disposition of multifamily housing projects and the...

40 CFR 35.290 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants State Indoor Radon Grants (section 306) § 35.290 Purpose. (a) Purpose... mitigate radon and that aim at reducing radon health risks. State Indoor Radon Grant funds may be used for...

36 CFR 290.4 - Confidentiality of cave location information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AGRICULTURE CAVE RESOURCES MANAGEMENT § 290.4 Confidentiality of cave location information. (a) Information... determines that disclosure will further the purposes of the Act and will not create a substantial risk of... Federal or State governmental agencies, bona fide educational or research institutes, or individuals or...

36 CFR 290.3 - Nomination, evaluation, and designation of significant caves.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF AGRICULTURE CAVE RESOURCES MANAGEMENT § 290.3 Nomination, evaluation, and designation of... humans, biota, or development of cave resources. (5) Recreational. The cave provides or could provide... consultation with individuals and organizations interested in the management and use of caves and cave...

15 CFR 290.7 - Proposal selection process.

Code of Federal Regulations, 2013 CFR

2013-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR... proposals will be reviewed by NIST to assure compliance with § 290.5 of these procedures. Proposals which... Director of NIST will appoint an evaluation panel to review and evaluate all qualified proposals in...

15 CFR 290.7 - Proposal selection process.

Code of Federal Regulations, 2011 CFR

2011-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR... proposals will be reviewed by NIST to assure compliance with § 290.5 of these procedures. Proposals which... Director of NIST will appoint an evaluation panel to review and evaluate all qualified proposals in...

15 CFR 290.7 - Proposal selection process.

Code of Federal Regulations, 2012 CFR

2012-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR... proposals will be reviewed by NIST to assure compliance with § 290.5 of these procedures. Proposals which... Director of NIST will appoint an evaluation panel to review and evaluate all qualified proposals in...

15 CFR 290.7 - Proposal selection process.

Code of Federal Regulations, 2014 CFR

2014-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR... proposals will be reviewed by NIST to assure compliance with § 290.5 of these procedures. Proposals which... Director of NIST will appoint an evaluation panel to review and evaluate all qualified proposals in...

15 CFR 290.7 - Proposal selection process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR... proposals will be reviewed by NIST to assure compliance with § 290.5 of these procedures. Proposals which... Director of NIST will appoint an evaluation panel to review and evaluate all qualified proposals in...

Tn5401, a new class II transposable element from Bacillus thuringiensis.

PubMed Central

Baum, J A

1994-01-01

A new class II (Tn3-like) transposable element, designated Tn5401, was recovered from a sporulation-deficient variant of Bacillus thuringiensis subsp. morrisoni EG2158 following its insertion into a recombinant plasmid. Sequence analysis of the insert revealed a 4,837-bp transposon with two large open reading frames, in the same orientation, encoding proteins of 36 kDa (306 residues) and 116 kDa (1,005 residues) and 53-bp terminal inverted repeats. The deduced amino acid sequence for the 36-kDa protein shows 24% sequence identity with the TnpI recombinase of the B. thuringiensis transposon Tn4430, a member of the phage integrase family of site-specific recombinases. The deduced amino acid sequence for the 116-kDa protein shows 42% sequence identity with the transposase of Tn3 but only 28% identity with the TnpA transposase of Tn4430. Two small open reading frames of unknown function, designated orf1 (85 residues) and orf2 (74 residues), were also identified. Southern blot analysis indicated that Tn5401, in contrast to Tn4430, is not commonly found among different subspecies of B. thuringiensis and is not typically associated with known insecticidal crystal protein genes. Transposition was studied with B. thuringiensis by using plasmid pEG922, a temperature-sensitive shuttle vector containing Tn5401. Tn5401 transposed to both chromosomal and plasmid target sites but displayed an apparent preference for plasmid sites. Transposition was replicative and resulted in the generation of a 5-bp duplication at the target site. Transcriptional start sites within Tn5401 were mapped by primer extension analysis. Two promoters, designated PL and PR, direct the transcription of orf1-orf2 and tnpI-tnpA, respectively, and are negatively regulated by TnpI. Sequence comparison of the promoter regions of Tn5401 and Tn4430 suggests that the conserved sequence element ATGTCCRCTAAY mediates TnpI binding and cointegrate resolution. The same element is contained within the 53-bp terminal inverted repeats, thus accounting for their unusual lengths and suggesting an additional role for TnpI in regulating Tn5401 transposition. Images PMID:7514590

36 CFR 290.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MANAGEMENT § 290.1 Purpose and scope. The rules of this part implement the requirements of the Federal Cave... management on National Forest System lands. These rules, in conjunction with rules in part 261 of this... outlined in the Forest Service Directive System and the management direction contained in the individual...

36 CFR 290.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... MANAGEMENT § 290.1 Purpose and scope. The rules of this part implement the requirements of the Federal Cave... management on National Forest System lands. These rules, in conjunction with rules in part 261 of this... outlined in the Forest Service Directive System and the management direction contained in the individual...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 290.27 - Up-front grants and loans.

Code of Federal Regulations, 2014 CFR

2014-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.27 Up-front grants and loans. (a) General. HUD... development costs as part of the disposition of a multifamily housing project that is HUD-owned, upon making a...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 290.27 - Up-front grants and loans.

Code of Federal Regulations, 2012 CFR

2012-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.27 Up-front grants and loans. (a) General. HUD... development costs as part of the disposition of a multifamily housing project that is HUD-owned, upon making a...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

40 CFR 1065.290 - PM gravimetric balance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false PM gravimetric balance. 1065.290... balance. (a) Application. Use a balance to weigh net PM on a sample medium for laboratory testing. (b) Component requirements. We recommend that you use a balance that meets the specifications in Table 1 of...

40 CFR 1065.290 - PM gravimetric balance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false PM gravimetric balance. 1065.290... balance. (a) Application. Use a balance to weigh net PM on a sample medium for laboratory testing. (b) Component requirements. We recommend that you use a balance that meets the specifications in Table 1 of...

5 CFR 792.102 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... EMPLOYEES' HEALTH AND COUNSELING PROGRAMS Regulatory Requirements for Alcoholism and Drug Abuse Programs and..., alcoholism, and/or drug abuse required under 42 U.S.C. 290dd-1(a) and 290ee-1(a). Federal departments and... employees with alcohol and/or drug problems. Short-term counseling and/or referral, or offers thereof, shall...

5 CFR 792.102 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... EMPLOYEES' HEALTH AND COUNSELING PROGRAMS Regulatory Requirements for Alcoholism and Drug Abuse Programs and..., alcoholism, and/or drug abuse required under 42 U.S.C. 290dd-1(a) and 290ee-1(a). Federal departments and... employees with alcohol and/or drug problems. Short-term counseling and/or referral, or offers thereof, shall...

5 CFR 792.102 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... EMPLOYEES' HEALTH AND COUNSELING PROGRAMS Regulatory Requirements for Alcoholism and Drug Abuse Programs and..., alcoholism, and/or drug abuse required under 42 U.S.C. 290dd-1(a) and 290ee-1(a). Federal departments and... employees with alcohol and/or drug problems. Short-term counseling and/or referral, or offers thereof, shall...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

32 CFR Appendix D to Part 290 - Audit Working Papers

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Audit Working Papers D Appendix D to Part 290 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt...

Magnetohydrodynamic models of bipolar knotty jet in henize 2-90

NASA Technical Reports Server (NTRS)

Lee, C.; Sahai, R.

2004-01-01

A remarkably linear, bipolar, knotty jet was recently discovered in Hen 2-90, an object classified as a young planetary nebula. Using two-dimensional, magnetohydrodynamic simulations, we investigate periodic variations in jet density and velocity as the mechanism for producing the jet and its knotty structures.

Effects of site-directed mutagenesis of Asn116 in the β-hairpin of the N-terminal domain of thermolysin on its activity and stability.

PubMed

Menach, Evans; Yasukawa, Kiyoshi; Inouye, Kuniyo

2012-09-01

In the N-terminal domain of thermolysin, two anti-parallel β-strands, Asn112-Ala113-Phe114-Trp115 and Ser118-Gln119-Met120-Val121-Tyr122 are connected by an Asn116-Gly117 turn to form a β-hairpin structure. In this study, we examined the role of Asn116 in the activity and stability of thermolysin by site-directed mutagenesis. Of the 19 Asn116 variants, four (N116A, N116D, N116T and N116Q) were produced in Escherichia coli, by co-expressing the mature and pro domains separately, while the other 15 were not. In the hydrolysis of N-[3-(2-furyl)acryloyl]-glycyl-L-leucine amide (FAGLA) at 25°C, the intrinsic k(cat)/K(m) value of N116D was 320% of that of the wild-type thermolysin (WT), and in the hydrolysis of N-carbobenzoxy-L-aspartyl-L-phenylalanine methyl ester (ZDFM) at pH 7.5 at 25°C, the k(cat)/K(m) value of N116D was 140% of that of WT, indicating that N116D exhibited higher activity than WT. N116Q exhibited similar activity as WT, and N116A and N116T exhibited reduced activities. The first-order rate constants, k(obs), of the thermal inactivation at 80°C were in the order N116A, N116D, N116T > N116Q > WT at all CaCl(2) concentrations examined (1-100 mM), indicating that all variants exhibited reduced stabilities. These results suggest that Asn116 plays an important role in the activity and stability of thermolysin presumably by stabilizing this β-hairpin structure.

Evaluation of the Utility of Static and Adaptive Mesh Refinement for Idealized Tropical Cyclone Problems in a Spectral Element Shallow Water Model

DTIC Science & Technology

2015-04-09

where u is the zonal momentum per unit mass, v is the meridional momentum per unit mass, h is the fluid depth, and f is the Coriolis parameter. An...from each cyclone advects the other116 creating a net cyclonic motion (the Fujiwhara effect ; Fujiwhara 1921) (case 2 idealization).117 In Fig. 2c, the...the interaction of the two136 vortices cause a net cyclonic motion (the Fujiwhara effect ).137 The initial condition for the binary vortex interaction

Thiosulfate as an Antidote to Mustard Poisoning, A Review of the Literature.

DTIC Science & Technology

1982-09-01

FRANCISCO CA UNCLASSIFIED K D MCKINLEY ET AL. SEP 82 LRIR-127 F/G 61209 N MENOMONEE NONIEhhhhhhhhhEND 1168 UL 1.0. * 1.25 I 1,1.6 MICROCOPY RESOLUTION TEST...ORGANIZATION NAME AND ADDRESS 10. PRORA ELEMENT. PROJECT, TASK AREA &J’WORC UNIT N UMSIERS Division of Research Support, Letterman ArmyPojN/3124A7 Institute...block 2,If different fram Report) I& SUPPLI111ENTARY NOTES I9. KEY WORDS (Centinue n reverse side If natessy and identlity5 b ock number) Sodium

Thermal Conductivity of Metals and Alloys at Low Temperatures. A Review of the Literature

DTIC Science & Technology

1954-09-01

between OnF and Ag , Ni. anda .. er.ta.. ducovruml s f (96) .. J m Sa . Oye-rveehg odciiy.. W.1 Powe28). sample .. &...... - .3a. IM. C.. Dp..... .Je...R. KikuchiBERYLIUM (932). Cominrl See figure 2, under "Metallic Elements".. E.J. Lewi 6.0 Ag ............. k= 1.16at27WC...9 Al 2 Zn, 0.1 .71 1.32 ........................ Aged . Mo. U ~5.Cu, 0.5 Si, 0.8 Fe, 0.5 Mn, 1.23 ......................... Quenched. MIA.B

Major and trace elements in Boletus aereus and Clitopilus prunulus growing on volcanic and sedimentary soils of Sicily (Italy).

PubMed

Alaimo, M G; Dongarrà, G; La Rosa, A; Tamburo, E; Vasquez, G; Varrica, D

2018-08-15

The aim of this study was to determine and compare the content of 28 elements (Ag, Al, As, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Rb, Sb, Se, Sr, Tl, U, V and Zn) in fruiting bodies of Boletus aereus Bull. and Clitopilus prunulus P. Kumm collected from eleven unpolluted sites of Sicily (Italy) and, also to relate the abundance of chemical elements in soil with their concentration in mushrooms. Median concentrations of the most abundant elements in Boletus aereus ranged from 31,290 μg/g (K) to 107 μg/g (Zn) in caps and from 24,009 μg/g (K) to 57 μg/g (Zn) in stalks with the following abundance order: K > Na > Ca > Mg > Fe > Al > Rb > Zn. The same elements, in the whole fruiting body of Clitopilus prunulus samples, varied in the range 54,073-92 μg/g following the abundance order: K > Na > Mg > Ca > Fe > Al > Rb > Zn. Metal contents in Boletus aereus and in the whole fruiting body of Clitopilus prunulus, collected from the same sampling sites, showed statistically significant differences for most elements. In particular, Clitopilus prunulus contained around two to four times more Co, Cr, Fe, Mg, Mo, Pb, U and V than caps and stalks of Boletus aereus species which, in turn, was from two to four times more enriched in Cu, Se and Tl. Thus, the elemental content of Boletus aereus and Clitopilus prunulus appeared to be species-dependent. The distribution of chemical elements in Boletus aereus was not uniform throughout the whole fruiting body as most elements were significantly bioconcentrated in caps. Furthermore, the fruit bodies of Boletus aereus from the volcanic soil differed both in major and minor elements concentrations from those collected from sedimentary soils. Cadmium and lead concentrations were below the threshold limits for wild mushrooms proposed by EU Directives (2008 and 2015). The elemental content was not significantly influenced by soil pH. Copyright © 2018 Elsevier Inc. All rights reserved.

["I dreamed that I dreamed": some notes on the clinical evaluation of therapist interventions, exemplified by Deserno's case study (session 290)].

PubMed

Berns, U; Hemprich, L

2001-01-01

In No. 8, 48th year, August 1998, of the journal "Psychotherapie--Psychosomatik--Medizinische Psychologie" the tape recorder transcription of the 290th session of a long-term analysis was studied by three methods (BIP, Frames, ZBKT). The paper presented here was stimulated by this publication. From the author's viewpoint substantial clinical aspects of evaluation could be added by applying a clinical evaluation method developed by R. Langs and his corresponding concept of interpretation. Clinical vignettes exemplify the possibility to resolve pathological countertransference by using this evaluation method. With the help of this method the presented transcription of the 290th session is evaluated partially.

The Effect of Aviation Fuels Containing Low Amounts of Static Dissipater Additive on Electrostatic Charge Generation

DTIC Science & Technology

1994-05-01

60 9.44 22.67 105 53.3 3.4 11.5 70 963 22.6? 12: so 3.14 11 S so 9.73 22.57 135 Soo 3 4 116 s0 9.73 22.6? ISO 53.3 3.4 11.6 t00 9.75 22.67 165...50.0 3.4 11.6 I10 9.73 22.57 ISO 5O0. 3.4 11.6 120 9.73 22.67 115 50.0 3.4 11.6 130 9.76 22.67 210 50.0 3.4 11.6 140 9.73 22.67 225 S3.3 3.4 11.6I... ISO 9.75 22.67 240 50.0 3.4 11.6 160 9.67 22.67 255 50.0 3.4 11.6 170 I.53 22.67 270 50.* 3.4 11.6 Igo 9.46 22.67 265 5O0. 3.4 11.6U Ito 9.03 22.67

Religious and Spiritual Beliefs of Physicians.

PubMed

Robinson, Kristin A; Cheng, Meng-Ru; Hansen, Patrick D; Gray, Richard J

2017-02-01

The aim of this study is to describe religious and spiritual beliefs of physicians and examine their influence on the decision to pursue medicine and daily medical practice. An anonymous survey was e-mailed to physicians at a large, multidisciplinary tertiary referral center with satellite clinics. Data were collected from January 2014 through February 2014. There were 2097 respondents (69.1 % men), and number of practicing years ranged from ≤1 to ≥30. Primary care physicians or medical specialists represented 74.1 %, 23.6 % were in surgical specialties, and 2.3 % were psychiatrists. The majority of physicians believe in God (65.2 %), and 51.2 % reported themselves as religious, 24.8 % spiritual, 12.4 % agnostic, and 11.6 % atheist. This self-designation was largely independent of specialty except for psychiatrists, who were more likely report agnosticism (P = 0.003). In total, 29.0 % reported that religious or spiritual beliefs influenced their decision to become a physician. Frequent prayer was reported by 44.7 % of physicians, but only 20.7 % reported having prayed with patients. Most physicians consider themselves religious or spiritual, but the rates of agnosticism and atheism are higher than the general population. Psychiatrists are the least religious group. Despite the influence of religion on physicians' lives and medical practice, the majority have not incorporated prayer into patient encounters.

Prevalence of precore-defective mutant of hepatitis B virus in HBV carriers.

PubMed

Niitsuma, H; Ishii, M; Saito, Y; Miura, M; Kobayashi, K; Ohori, H; Toyota, T

1995-08-01

Two hundred and seventy-three serum specimens from hepatitis B virus (HBV) carriers were examined for the presence of a characteristic one point mutation at nucleotide (nt) 1896 from the EcoRI site of the HBV genome in the precore region (the preC mutant) using restriction fragment length polymorphism (RFLP) analysis. This assay approach could detect preC mutants or wild-type sequences when either form constituted more than 10% of the total sample. Overall, 65.5% (76/116) of HBeAg-positive carriers had only the preC wild-type. All HBeAg-positive asymptomatic carriers (n = 14) had only the preC wild-type. In patients with chronic hepatitis B and in anti-HBe-positive asymptomatic carriers, increased prevalence of the preC mutant was associated with the development of anti-HBe antibodies and normalization of the serum alanine aminotransferase concentration. Furthermore, 27 (29.0%) of 93 HBeAg-negative carriers had unexpectedly preC wild-type sequences only. Direct sequencing of the HBV precore region of HBV specimens from 24 patients revealed no mutation at nt 1896, supporting the specificity of the RFLP analysis. These results suggest that RFLP analysis was accurate for the detection of the preC mutation and that the absence of serum HBeAg cannot be explained solely by the dominance of the preC mutant.

Comparison of surgical outcomes among infants in neonatal intensive care units treated by pediatric surgeons versus general surgeons: The need for pediatric surgery specialists.

PubMed

Boo, Yoon Jung; Lee, Eun Hee; Lee, Ji Sung

2017-11-01

This study compared the outcomes of infants who underwent surgery in neonatal intensive care units by pediatric surgeons and by general surgeons. This was a retrospective study of infants who underwent surgery in neonatal intensive care units between 2010 and 2014. A total of 227 patients were included. Of these patients, 116 were operated on by pediatric surgeons (PS) and 111 were operated on by general surgeons (GS). The outcome measures were the overall rate of operative complications, unplanned reoperation, mortality rate, length of stay, operative time, and number of total number of operative procedures. The overall operative complication rate was higher in the GS group compared with the PS group (18.7% vs. 7.0%, p=0.0091). The rate of unplanned reoperations was also higher in the GS group (10.8% vs. 3.5%, p=0.0331). The median operation time (90min vs. 75min, p=0.0474) and median length of stay (24days vs. 18days, p=0.0075) were significantly longer in the GS group. The adjusted odd ratios of postoperative complications for GS were 2.9 times higher than that of PS (OR 2.90, p=0.0352). The operative quality and patient outcomes of the PS group were superior to those of the GS group. III. Copyright © 2017 Elsevier Inc. All rights reserved.

Motivations for and barriers to choosing an interventional cardiology career path: results from the EAPCI Women Committee worldwide survey.

PubMed

Capranzano, Piera; Kunadian, Vijay; Mauri, Josepa; Petronio, Anna Sonia; Salvatella, Neus; Appelman, Yolande; Gilard, Martine; Mikhail, Ghada W; Schüpke, Stefanie; Radu, Maria D; Vaquerizo, Beatriz; Presbitero, Patrizia; Morice, Marie-Claude; Mehilli, Julinda

2016-05-17

Very few women become interventional cardiologists, although a substantial proportion of cardiologists and the majority of medical students are women. In accordance with the EAPCI Women Committee mission of attaining gender equality at the professional level, a worldwide survey was recently conducted aiming to understand better the motivations and the barriers for women in selecting interventional cardiology (IC) as a career path. A total of 1,787 individuals (60.7% women) responded to the survey. Women compared to men were less frequently married (women vs. men, 57.0% vs. 79.8%, p<0.001) and more frequently childless (46.6% vs. 20.5%, p<0.002). The most prevalent reason for choosing IC was passion (83.3% vs. 76.1%, p=0.12), while those for not choosing were, sequentially, lack of opportunity (29.0% vs. 45.7%), radiation concerns (19.9% vs. 11.6%) and preference (16.2% vs. 29.5%), p<0.001. According to 652 men replying to why, in their opinion, women do not choose IC, on-calls and long working hours were the most frequent reasons (35.3%). Several barriers preclude women from choosing IC, including lack of opportunity, concerns regarding radiation exposure and the prejudices of their male colleagues. This highlights the need to develop new strategies for future training, education, and support of women in order to choose IC.

Efficient synthesis and evaluation of bis-pyridinium/bis-quinolinium metallosalophens as antibiotic and antitumor candidates

NASA Astrophysics Data System (ADS)

Elshaarawy, Reda F. M.; Eldeen, Ibrahim M.; Hassan, Eman M.

2017-01-01

Inspired with the pharmacological diversity of salophens and in our endeavor to explore a new strategy which may conflict the invasion of drug resistance, we report herein efficient synthetic routes for the synthesis of new RO-salophen(Cl), pyridinium/quinolinium-based salophens (3a-e) and metallosalophens (4a-j). These new architectures have been structurally characterized by elemental and spectral analysis as well pharmacologically evaluated for their in vitro antimicrobial, against a common panel of pathogenic bacterial and fungal strains, and anticancer activities against human colon carcinoma (HCT-116) cell lines. Antimicrobial assay results revealed that all tested compounds exhibited moderate to superb broad-spectrum efficacy in comparison to the standard antibiotic with a preferential ability to perform as a fungicides than to act as bactericides. Noteworthy, VO(II)-salophens are more effective in reduction HCT-116 cell viability than Cu(II)-salophens. For example, VO(II)-salophen3 (4f) (IC50 = 2.13 μg/mL) was ca. 10-fold more efficient than Cu(II)-salophen3 (4e) (IC50 = 20.30 μg/mL).

76 FR 52379 - Buy America Waiver Notification

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... 0.008 steel fiber with ultimate tensile strength of 290ksi for experimental use in Ultra High... for \\1/2\\'' x 0.008 steel fiber with ultimate tensile strength of 290ksi for experimental use in UHPC... there are no domestic manufacturers of \\1/2\\'' x 0.008 steel fiber with ultimate tensile strength of...

27 CFR 24.290 - Removal of wine as distilling material.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removal of wine as... TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Removal, Return and Receipt of Wine Removals Without Payment of Tax § 24.290 Removal of wine as distilling material. (a) General. Still wine may be...

30 CFR 250.290 - What operations require approval of the Conceptual Plan?

Code of Federal Regulations, 2010 CFR

2010-07-01

... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Deepwater Operations Plans (dwop) § 250.290 What operations require approval of the Conceptual Plan? You may... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What operations require approval of the...

77 FR 6134 - Agency Information Collection Activities: Form I-290B, Extension of an Existing Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

...: 60-Day Notice of Information Collection Under Review: Form I- 290B, Notice of Appeal or Motion...., permitting electronic submission of responses. Overview of this information collection: (1) Type of...: Notice of Appeal or Motion. (3) Agency form number, if any, and the applicable component of the...

76 FR 34064 - Procurement List; Proposed Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

... the Department of Defense, as aggregated by the Defense Logistics Agency Troop Support, Philadelphia...--Envelope, Bubble Padded, 14\\1/2\\'' x 20''. NSN: 8105-00-290-0340--Envelope, Macerated Paper Padded, 6'' x 10''. NSN: 8105-00-290-0343--Envelope, Macerated Paper Padded, 8\\1/2\\'' x 12''. NSN: 8105-00-281-1168...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2011 CFR

2011-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2012 CFR

2012-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2014 CFR

2014-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

50 CFR 648.290 - Tilefish Annual Catch Limit (ACL).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Tilefish Annual Catch Limit (ACL). 648... Measures for the Tilefish Fishery § 648.290 Tilefish Annual Catch Limit (ACL). (a) The Tilefish Monitoring Committee shall recommend to the MAFMC an ACL for the commercial tilefish fishery, which shall be equal to...

50 CFR 648.290 - Tilefish Annual Catch Limit (ACL).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Tilefish Annual Catch Limit (ACL). 648... Measures for the Tilefish Fishery § 648.290 Tilefish Annual Catch Limit (ACL). (a) The Tilefish Monitoring Committee shall recommend to the MAFMC an ACL for the commercial tilefish fishery, which shall be equal to...

50 CFR 648.290 - Tilefish Annual Catch Limit (ACL).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Tilefish Annual Catch Limit (ACL). 648... Measures for the Tilefish Fishery § 648.290 Tilefish Annual Catch Limit (ACL). (a) The Tilefish Monitoring Committee shall recommend to the MAFMC an ACL for the commercial tilefish fishery, which shall be equal to...

50 CFR 648.290 - Individual fishing quota program and other restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Individual fishing quota program and other... Management Measures for the Tilefish Fishery § 648.290 Individual fishing quota program and other restrictions. The fishing year is the 12-month period beginning with November 1, 2001. (a)Total allowable...

17 CFR 290.4 - Preparation and filing of reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... BANK FOR RECONSTRUCTION AND DEVELOPMENT ACT § 290.4 Preparation and filing of reports. (a) Every report.... (c) The report shall be in the English language. If any exhibit or other paper or document filed with the report is in a foreign language, it shall be accompanied by a translation into the English...

76 FR 11436 - Application to Export Electric Energy; Ontario Power Generation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... facilities. DOE renewed the OPG export authorization on June 21, 2006 in Order No. EA-290-A. Order No. EA-290..., Federal power marketing agencies, and other entities within the United States. The existing international transmission facilities to be utilized by OPG have previously been authorized by Presidential permits issued...

Zika-Virus-Related Photo Sharing on Pinterest and Instagram.

PubMed

Fung, Isaac Chun-Hai; Blankenship, Elizabeth B; Goff, M Elizabeth; Mullican, Lindsay A; Chan, Kwun Cheung; Saroha, Nitin; Duke, Carmen H; Eremeeva, Marina E; Fu, King-Wa; Tse, Zion Tsz Ho

2017-12-01

Pinterest (San Francisco, CA) and Instagram (Menlo Park, CA) are 2 popular photo-sharing social media platforms among young individuals. We assessed differences between Instagram and Pinterest in relaying photographic information regarding Zika virus. Specifically, we investigated whether the percentage of Zika-virus-related photos with Spanish or Portuguese texts embedded therein was higher for Instagram than for Pinterest and whether the contents of Zika-virus-related photos shared on Pinterest were different from those shared on Instagram. We retrieved and manually coded 616 Pinterest (key words: "zika" AND "virus") and 616 Instagram (hashtag: #zikavirus) photos. Among the manually coded samples, 47% (290/616) of Pinterest photos and 23% (144/616) of Instagram photos were relevant to Zika virus. Words were embedded in 57% (164/290) of relevant Pinterest photos and all 144 relevant Instagram photos. Among the photos with embedded words, photos in Spanish or Portuguese were more prevalent on Instagram (77/144, 53%) than on Pinterest (14/164, 9%). There were more Zika-virus-related photos on Instagram than on Pinterest pertinent to Zika virus prevention (59/144, 41%, versus 41/290, 14%; P<0.0001), the effects of Zika virus on pregnancy (27/144, 19%, versus 32/290, 11%; P=0.04), and Zika-virus-associated deaths (4/144, 2%, versus 0/290, 0%; P=0.01). Pinterest and Instagram are similar platforms for Zika virus prevention communication. (Disaster Med Public Health Preparedness. 2017;11:656-659).

Seaweeds along KwaZulu-Natal coast of South Africa-3: elemental uptake by Ulva lactuca (Sea lettuce).

PubMed

Misheer, Natasha; Kindness, A; Jonnalagadda, S B

2006-01-01

The elemental uptake by Ulva lactuca (Sea lettuce), a marine macro-algae (chlorophyta, green alga) grown richly along KwaZulu-Natal coastline. The total elemental concentrations of seven important elements, namely manganese, iron, arsenic, boron, titanium, zinc and mercury, selected based on their abundance in U. lactuca were investigated for one year cycle (June 2002 to May 2003). The four selected sampling sites, Zinkwasi, Ballito, Treasure Beach and Park Ryrie are spread over 150 km wide along the KwaZulu-Natal coastline from North to South. The Ulva lectuca possess good manganese and arsenic accumulating ability and an excellent bio-indicator for most of the metals studied. A typical U. lectuca sample at Zinkwasi (in winter) recorded Mn (25.3 +/- 1.16 ppm), Fe (21.0 +/- 0.85 ppm), As (6.2 +/- 0.30 ppm), B (935 +/- 14 ppb), Ti (863 +/- 34 ppb), Zn (421 +/- 21 ppb), and Hg (61.3 +/- 1.2 ppb). The general trend found at all sites was high elemental concentrations in winter and a decrease in concentrations from winter to spring and summer. Iron uptake was lowest in summer and autumn at all sites. Ulva lactuca recorded highest mercury levels (>400 ppb) during the spring season at the Treasure Beach site near Durban.

Determination of trace elements in epiphytic lichens from Bandar Baru Bangi, Selangor using INAA method

NASA Astrophysics Data System (ADS)

Khairudin, Nurshafiq Ezam; Siong, Khoo Kok; Siong, Wee Boon

2014-02-01

Lichens have been used as effective biomonitors of atmospheric pollutants as they can take up nutrients and pollutants directly from the atmosphere. In this study, trace element contents in epiphytic lichens were determined using INAA method. Samples were collected from 7 sampling locations around Bandar Baru Bangi, Selangor. The elements detected were As (1.73+0.85 mg/kg), Ce (3.65+1.91 mg/kg), Co (0.29+0.12 mg/kg), Cr (5.92+3.54 mg/kg), Cs (0.92+0.25 mg/kg), Eu (0.03+0.02 mg/kg), Fe (1280+760 mg/kg), Hf (0.37+0.18 mg/kg), La (1.52+0.89 mg/kg), Rb (27.7+4.8 mg/kg), Sc (0.33+0.19 mg/kg), Sm (0.28+0.16 mg/kg), Th (1.21+0.62 mg/kg) and Zn (116+27 mg/kg). Comparisons were then made between the elemental concentrations obtained and the baseline data from literature. Results showed that most of the elements were within the concentration range of the baseline data. Enrichment factors (EF) of the trace element in lichens showed that most of the elements were within the range of the baseline data except for As which was found to be slightly enriched (EF: 13.2 - 28.5). Regression analysis indicated significant correlation (p<0.05) with Sc for most of the elements which signifies crustal input except for Cs and Rb. The poor correlations of Cs and Rb with Sc may be due to the mobility of these elements. In summary, trace element data obtained using INAA were very useful and demonstrated that lichens were suitable biomonitors for identifying potential trace element pollutants in ambient air around the sampling area.

Effects of Added Resistance Training on Physical Fitness, Body Composition, and Serum Hormone Concentrations During Eight Weeks of Special Military Training Period.

PubMed

Vaara, Jani P; Kokko, Juha; Isoranta, Manne; Kyröläinen, Heikki

2015-11-01

A high volume of military training has been shown to compromise muscle strength development. We examined effects of added low-volume resistance training during special military training (ST) period, which took place after basic training period. Male conscripts (n = 25) were assigned to standardized ST with added resistance training group (TG, n = 13) and group with standardized ST only (control) (CG, n = 12). Standardized ST with added resistance training group performed 2 resistance training sessions per week for 8 weeks: hypertrophic strength (weeks 1-3), maximal strength (weeks 4-6) and power training (weeks 7-8). Maximal strength tests, load carriage performance (3.2 km, 27 kg), and hormone concentrations were measured before and after ST (mean ± SD). Both groups improved similarly in their load carriage performance time (TG: 1,162 ± 116 seconds vs. 1,047 ± 81 seconds; CG: 1,142 ± 95 seconds vs. 1,035 ± 81 seconds) (p < 0.001) but decreased maximal strength of the lower extremities (TG: 5,250 ± 1,110 N vs. 4,290 ± 720 N; CG: 5,170 ± 1,050 N vs. 4,330 ± 1,230 N) and back muscles (TG: 4,290 ± 990 N vs. 3,570 ± 48 N; CG: 3,920 ± 72 N vs. 3,410 ± 53 N) (p ≤ 0.05). Maximal strength of the upper extremities improved in CG (1,040 ± 200 N vs. 1,140 ± 200 N) (p ≤ 0.05) but not in TG. Maximal strength of the abdominal muscles improved in TG (3,260 ± 510 N vs. 3,740 ± 75 N) (p ≤ 0.05) but not in CG. Testosterone concentration increased in CG (15.2 ± 3.6 nmol·L⁻¹ vs. 21.6 ± 5.0 nmol·L⁻¹) (p < 0.01) but not in TG (18.6 ± 4.3 nmol·L⁻¹ vs. 19.5 ± 9.4 nmol·L⁻¹). In conclusion, interference with strength gains might be related to the high volume of aerobic activities and too low volume of resistance training during ST. To develop strength characteristics, careful periodization and individualization should be adopted in ST.

78 FR 63563 - Buy America Waiver Notification

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2013-10-24

.... steel fibers with ultimate tensile strength of 290 ksi. in Ultra High Performance Concrete (UHPC) at the... appropriate to use UHPC 0.5 in. x 0.008 in. steel fibers with ultimate tensile strength 290 ksi. on Federal... for the use of non-domestic UHPC 0.5 in. x 0.008 in. steel fibers with ultimate tensile strength of...

76 FR 10609 - Agency Information Collection Activities: Form I-290B, Revision of an Existing Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

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76 FR 47564 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

...-117-9886--Envelope, Bubble Padded, 14\\1/2\\'' x 20''. NSN: 8105-00-290-0340--Envelope, Macerated Paper Padded, 6'' x 10''. NSN: 8105-00-290-0343--Envelope, Macerated Paper Padded, 8\\1/2\\'' x 12''. NSN: 8105-00-281-1168--Envelope, Macerated Paper Padded, 9\\1/2\\'' x 14\\1/2\\''. NSN: 8105-00-281-1436--Envelope...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2011 CFR

2011-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2014 CFR

2014-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2010 CFR

2010-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2012 CFR

2012-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, et seq., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, et seq., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

42 CFR 54a.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TITLE V OF THE PUBLIC HEALTH SERVICE ACT, 42 U.S.C. 290aa, ET SEQ., FOR SUBSTANCE ABUSE PREVENTION AND... of the PHS Act, 42 U.S.C. 290aa, et seq., for the provision of substance abuse prevention and or... beneficiary means an individual who receives substance abuse services under a program funded in whole or in...

41 CFR 102-38.290 - What types of payment may we accept?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What types of payment... PROPERTY Completion of Sale Payments § 102-38.290 What types of payment may we accept? You must adopt a payment policy that protects the Government against fraud. Acceptable payments include, but are not...

14. OBLIQUE VIEW OF UPPER ORE BIN AND LOADING DECK, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. OBLIQUE VIEW OF UPPER ORE BIN AND LOADING DECK, LOOKING WEST. DETAIL OF SUPPORTING TIMBERS. THE LOCATION OF THIS ORE BIN IN RELATION TO THE MILL CAN BE SEEN IN MANY OF THE MILL OVERVIEWS. (CA-290-4 THROUGH CA-290-8). - Skidoo Mine, Park Route 38 (Skidoo Road), Death Valley Junction, Inyo County, CA

40 CFR 80.290 - How does a refiner apply for a sulfur baseline?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 17 2014-07-01 2014-07-01 false How does a refiner apply for a sulfur... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Averaging, Banking and Trading (abt) Program-General Information § 80.290 How does a refiner apply for a sulfur baseline? (a) The...

40 CFR 80.290 - How does a refiner apply for a sulfur baseline?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false How does a refiner apply for a sulfur... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Averaging, Banking and Trading (abt) Program-General Information § 80.290 How does a refiner apply for a sulfur baseline? (a) The...

40 CFR 80.290 - How does a refiner apply for a sulfur baseline?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 16 2011-07-01 2011-07-01 false How does a refiner apply for a sulfur... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Averaging, Banking and Trading (abt) Program-General Information § 80.290 How does a refiner apply for a sulfur baseline? (a) The...

40 CFR 80.290 - How does a refiner apply for a sulfur baseline?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 17 2012-07-01 2012-07-01 false How does a refiner apply for a sulfur... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Averaging, Banking and Trading (abt) Program-General Information § 80.290 How does a refiner apply for a sulfur baseline? (a) The...

40 CFR 80.290 - How does a refiner apply for a sulfur baseline?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 17 2013-07-01 2013-07-01 false How does a refiner apply for a sulfur... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Averaging, Banking and Trading (abt) Program-General Information § 80.290 How does a refiner apply for a sulfur baseline? (a) The...

Increased levels of circulating nitrates and impaired endothelium-mediated vasodilation suggest multiple roles of nitric oxide during acute rejection of pulmonary allografts.

PubMed

Wiklund, L; Lewis, D H; Sjöquist, P O; Nilsson, F; Tazelaar, H; Miller, V M; McGregor, C G

1997-05-01

Experiments were designed to determine whether changes in pulmonary artery function could be reduced by treatment with a lipid peroxidation inhibitor (H 290/51) during acute rejection of pulmonary allografts. Single lung transplantation was performed in three groups of dogs: group 1 was maintained on immunosuppression for 8 days after operation (immunosuppressed, n = 5); in group 2, immunosuppression was discontinued on postoperative day 5, so that rejection occurred on postoperative day 8 (rejecting, n = 6); in group 3, immunosuppression was discontinued after 5 days, and the lipid peroxidation inhibitor H 290/51 (25 mg/kg) was given perorally for 3 days (rejecting + H 290/51, n = 6). Plasma nitric oxide (NO(x)) was measured by use of chemoluminescence. On postoperative day 8 rejection was observed in groups 2 and 3. Contractions to angiotensin I and endothelium-dependent relaxations to adenosine diphosphate were reduced in pulmonary arteries from rejecting lungs. Responses of rings from dogs treated with H 290/51 were similar to those from rejecting lungs. Rejection did not alter relaxations to exogenous nitric oxide. However, plasma levels of NO(x) increased significantly during rejection independently of treatment with H 290/51. Results of this study confirm that endothelium-dependent relaxation of pulmonary arteries is reduced during acute rejection of lung allografts. The result extends these observations to suggest that treatment with a lipid peroxidation inhibitor neither protects the pulmonary artery function nor affects levels of circulating NO(x). Therefore mechanisms other than lipid peroxidation participate in vascular changes associated with allograft rejection.

Osmotic characteristics and fertility of murine spermatozoa collected in different solutions.

PubMed

Si, Wei; Men, Hongsheng; Benson, James D; Critser, John K

2009-02-01

Osmotic stress is an important factor that can result in cell damage during cryopreservation. Before ejaculation or collection for cryopreservation, murine spermatozoa are stored in epididymal fluid, a physiologically hyperosmotic environment (approximately 415 mmol/kg). The objectives of this study were to determine the osmotic tolerance limits of sperm motion parameters of ICR and C57BL/6 mouse spermatozoa collected in isosmotic (290 mmol/kg) and hyperosmotic (415 mmol/kg) media, and the effect of the osmolality of sperm collection media on sperm fertility after cryopreservation. Our results indicate that murine spermatozoa collected in media with different osmolalities (290 and 415 mmol/kg Dulbecco's phosphate buffered saline (DPBS)) appeared to have different osmotic tolerances for the maintenance of sperm motility and other motion parameters in both mouse strains. The hypo- and hyperosmotic treatments decreased motility and affected other motion parameters of spermatozoa collected in 290 mmol/kg DPBS. The extent of the change of motion parameters after treatments corresponded with the levels of osmotic stress. However, for spermatozoa collected in 415 mmol/kg DPBS, exposure to 290 mmol/kg DPBS tended to increase sperm motility and the quality of their motion parameters. The osmolality of sperm collection medium can affect murine sperm fertility. Spermatozoa collected in 415 mmol/kg medium showed higher fertility compared with spermatozoa collected in 290 mmol/kg as assessed by IVF. Results characterizing murine sperm osmotic tolerance collected in media with different osmolalities from different strains and the effect of collection media osmolality on sperm fertility after cryopreservation will be useful in designing cryopreservation protocols.

77 FR 69931 - Art Advisory Panel; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... 6, 2012, at 290 Broadway, Foley Square, New York, New York 10007 at 9:30 a.m. FOR FURTHER INFORMATION CONTACT: Ruth M. Vriend, C:AP:SO:ART, 1111 Constitution Ave. NW., Washington, DC 20024. Telephone... Advisory Panel will be held on December 6, 2012, at 290 Broadway, Foley Square at 9:30 a.m., New York, NY...

48 CFR 2901.105-2 - Arrangement of regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... preceded with a 29 or a 290 such that there will always be four numbers to the left of the first decimal. For example, the DOLAR implementation of FAR l.105-l is shown as 290l.105-1 and the DOLAR..., FAR l.104-2(c)(2). References to DOLAR materials within the DOLAR simply cite the identifying number...

48 CFR 2901.105-2 - Arrangement of regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... preceded with a 29 or a 290 such that there will always be four numbers to the left of the first decimal. For example, the DOLAR implementation of FAR l.105-l is shown as 290l.105-1 and the DOLAR..., FAR l.104-2(c)(2). References to DOLAR materials within the DOLAR simply cite the identifying number...

48 CFR 2901.105-2 - Arrangement of regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... preceded with a 29 or a 290 such that there will always be four numbers to the left of the first decimal. For example, the DOLAR implementation of FAR l.105-l is shown as 290l.105-1 and the DOLAR..., FAR l.104-2(c)(2). References to DOLAR materials within the DOLAR simply cite the identifying number...

48 CFR 2901.105-2 - Arrangement of regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... preceded with a 29 or a 290 such that there will always be four numbers to the left of the first decimal. For example, the DOLAR implementation of FAR l.105-l is shown as 290l.105-1 and the DOLAR..., FAR l.104-2(c)(2). References to DOLAR materials within the DOLAR simply cite the identifying number...

48 CFR 2901.105-2 - Arrangement of regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... preceded with a 29 or a 290 such that there will always be four numbers to the left of the first decimal. For example, the DOLAR implementation of FAR l.105-l is shown as 290l.105-1 and the DOLAR..., FAR l.104-2(c)(2). References to DOLAR materials within the DOLAR simply cite the identifying number...

High transmission Ni compound refractive lens for high energy X-rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brancewicz, M., E-mail: brancew@spring8.or.jp; Itou, M.; Sakurai, Y.

We present a new planar Ni compound refractive lens for high energy X-rays (116 keV). The lens is composed of identical plano-concave elements with longitudinal parabolic grooves manufactured by a punch technique. In order to increase the lens transmission, the thickness of the single lens at the parabolic groove vertex was reduced to less than 5 μm and the radius of curvature was reduced to about 20 μm. The small radius of curvature allowed us to reduce the number of single elements needed to get the focal length of 3 m to 54 single lenses. The gain parameter has beenmore » significantly improved compared to the previous lenses due to higher transmission, but the focused beam size and its gain are not as good as expected, mostly due to the aberrations caused by the lens shape imperfections.« less

Translating infection control guidelines into practice: implementation process within a health care institution.

PubMed

Raveis, Victoria H; Conway, Laurie J; Uchida, Mayuko; Pogorzelska-Maziarz, Monika; Larson, Elaine L; Stone, Patricia W

2014-04-01

Health-care-associated infections (HAIs) remain a major patient safety problem even as policy and programmatic efforts designed to reduce HAIs have increased. Although information on implementing effective infection control (IC) efforts has steadily grown, knowledge gaps remain regarding the organizational elements that improve bedside practice and accommodate variations in clinical care settings. We conducted in-depth, semistructured interviews in 11 hospitals across the United States with a range of hospital personnel involved in IC (n = 116). We examined the collective nature of IC and the organizational elements that can enable disparate groups to work together to prevent HAIs. Our content analysis of participants' narratives yielded a rich description of the organizational process of implementing adherence to IC. Findings document the dynamic, fluid, interactional, and reactive nature of this process. Three themes emerged: implementing adherence efforts institution-wide, promoting an institutional culture to sustain adherence, and contending with opposition to the IC mandate.

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels

PubMed Central

Gu, Chunfang; Wilson, Miranda S. C.; Jessen, Henning J.; Saiardi, Adolfo; Shears, Stephen B.

2016-01-01

The HCT116 cell line, which has a pseudo-diploid karotype, is a popular model in the fields of cancer cell biology, intestinal immunity, and inflammation. In the current study, we describe two batches of diverged HCT116 cells, which we designate as HCT116NIH and HCT116UCL. Using both gel electrophoresis and HPLC, we show that HCT116UCL cells contain 6-fold higher levels of InsP8 than HCT116NIH cells. This observation is significant because InsP8 is one of a group of molecules collectively known as ‘inositol pyrophosphates’ (PP-InsPs)—highly ‘energetic’ and conserved regulators of cellular and organismal metabolism. Variability in the cellular levels of InsP8 within divergent HCT116 cell lines could have impacted the phenotypic data obtained in previous studies. This difference in InsP8 levels is more remarkable for being specific; levels of other inositol phosphates, and notably InsP6 and 5-InsP7, are very similar in both HCT116NIH and HCT116UCL lines. We also developed a new HPLC procedure to record 1-InsP7 levels directly (for the first time in any mammalian cell line); 1-InsP7 comprised <2% of total InsP7 in HCT116NIH and HCT116UCL lines. The elevated levels of InsP8 in the HCT116UCL lines were not due to an increase in expression of the PP-InsP kinases (IP6Ks and PPIP5Ks), nor to a decrease in the capacity to dephosphorylate InsP8. We discuss how the divergent PP-InsP profiles of the newly-designated HCT116NIH and HCT116UCL lines should be considered an important research opportunity: future studies using these two lines may uncover new features that regulate InsP8 turnover, and may also yield new directions for studying InsP8 function. PMID:27788189

0{nu}{beta}{beta}-decay nuclear matrix elements with self-consistent short-range correlations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simkovic, Fedor; Bogoliubov Laboratory of Theoretical Physics, JINR, RU-141 980 Dubna, Moscow region; Department of Nuclear Physics, Comenius University, Mlynska dolina F1, SK-842 15 Bratislava

A self-consistent calculation of nuclear matrix elements of the neutrinoless double-beta decays (0{nu}{beta}{beta}) of {sup 76}Ge, {sup 82}Se, {sup 96}Zr, {sup 100}Mo, {sup 116}Cd, {sup 128}Te, {sup 130}Te, and {sup 136}Xe is presented in the framework of the renormalized quasiparticle random phase approximation (RQRPA) and the standard QRPA. The pairing and residual interactions as well as the two-nucleon short-range correlations are for the first time derived from the same modern realistic nucleon-nucleon potentials, namely, from the charge-dependent Bonn potential (CD-Bonn) and the Argonne V18 potential. In a comparison with the traditional approach of using the Miller-Spencer Jastrow correlations, matrix elementsmore » for the 0{nu}{beta}{beta} decay are obtained that are larger in magnitude. We analyze the differences among various two-nucleon correlations including those of the unitary correlation operator method (UCOM) and quantify the uncertainties in the calculated 0{nu}{beta}{beta}-decay matrix elements.« less

Search for double beta decay of 116Cd with enriched 116CdWO4 crystal scintillators (Aurora experiment)

NASA Astrophysics Data System (ADS)

Danevich, F. A.; Barabash, A. S.; Belli, P.; Bernabei, R.; Cappella, F.; Caracciolo, V.; Cerulli, R.; Chernyak, D. M.; d'Angelo, S.; Incicchitti, A.; Kobychev, V. V.; Konovalov, S. I.; Laubenstein, M.; Mokina, V. M.; Poda, D. V.; Polischuk, O. G.; Shlegel, V. N.; Tretyak, V. I.; Umatov, V. I.

2016-05-01

The Aurora experiment to investigate double beta decay of 116 Cd with the help of 1.162 kg cadmium tungstate crystal scintillators enriched in 116 Cd to 82% is in progress at the Gran Sasso Underground Laboratory. The half-life of 116 Cd relatively to the two neutrino double beta decay is measured with the highest up-to-date accuracy T1/2 = (2.62 ± 0.14) × 1019 yr. The sensitivity of the experiment to the neutrinoless double beta decay of 116 Cd to the ground state of 116 Sn is estimated as T1/2 ≥ 1.9 × 1023 yr at 90% CL, which corresponds to the effective Majorana neutrino mass limit (mv) ≤ (1.2 — 1.8) eV. New limits are obtained for the double beta decay of 116 Cd to the excited levels of 116 Sn, and for the neutrinoless double beta decay with emission of majorons.

33 CFR 165.T08-290 - Safety Zone; Gulf of Mexico-Johns Pass, Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone; Gulf of Mexico-Johns... § 165.T08-290 Safety Zone; Gulf of Mexico—Johns Pass, Florida. (a) Regulated area. The Coast Guard is establishing a temporary safety zone on the waters of the Gulf of Mexico, Florida, in the vicinity of the John...

DoD Educational Intervention Programs for Scientists and Engineers.

DTIC Science & Technology

1995-10-01

Nabeel , ed. The Condition of Education: 1993. Washington, D.C.: U.S.Department of Education, National Center for Education Statistics (NCES 93-290), p...Naval Facilities I Undergraduate Academic Program Undergraduate Navy Naval Ocean Sy Cooperative Education Program (COOP) Undergraduate Navy Naval... Nabeel , ed. The Condition of Education: 1993. Washington, D.C.: U.S. Department of Education, National Center for Education Statistics (NCES 93-290

Trace element concentrations in two subpopulations of lesser snow geese from Wrangel Island, Russia

USGS Publications Warehouse

Hui, A.; Takekawa, John Y.; Baranyuk, Vasily V.; Litvin, K.V.

1998-01-01

Lesser snow geese (Anser c. caerulescens) from the Wrangel Island, Russia breeding colony spend the winter in two widely separated areas: the northern subpopulation in southern British Columbia and northern Washington and the southern subpopulation in the Central Valley of California. We examined 19 trace elements in the eggs and livers of geese from these two subpopulations to examine whether geese from the different wintering areas have similar trace element burdens. Eggs collected at the breeding colony from geese of the southern subpopulation had slightly higher levels of manganese, an element that can cause neurological damage and behavioral changes in chicks, than geese of the northern subpopulation. Livers from adult geese collected on the two wintering areas showed significant differences in trace elements including copper, iron, magnesium, molybdenum, and zinc. Copper concentrations in the livers of geese from the southern subpopulation were much higher than those from the northern subpopulation (x¯ = 116 vs. 46 ppm; dry weight). Elevated levels of copper may induce anemia in birds. The differences in trace element concentrations of these two subpopulations may be related to farming practices in their wintering areas. Geese from the northern subpopulation feed in pastures and coastal marshes and migrate along the coast, but geese from the southern subpopulation feed predominantly in rice fields and migrate over farm land. Copper and manganese are major components of fertilizers and fungicides commonly applied during rice cultivation.

Pygoscelis antarcticus feathers as bioindicator of trace element risk in marine environments from Barton Peninsula, 25 de Mayo (King George) Island, Antarctica.

PubMed

Catán, Soledad Perez; Bubach, Debora; Di Fonzo, Carla; Dopchiz, Laura; Arribére, Maria; Ansaldo, Martin

2017-04-01

We report the contents of elements in feathers of Chinstrap penguin (Pygoscelis antarcticus), which had not been informed up to now, such as silver and bromine and others listed as hazardous by the United States Environmental Protection Agency as arsenic, cobalt, chromium, and mercury. Analyses of the element concentrations in feathers, adult and chicken, from Barton Peninsulas at 25 de Mayo (King George) Island, South Shetlands, were made by Instrumental Neutron Activation Analysis. Samarium, lanthanum a, thorium, and uranium concentrations in Chinstrap penguin feathers were below 0.1 mg/kg. This suggests that the elements in feather do not come from atmospheric particles surface deposition. Arsenic (0.120 ± 0.050 mg/kg) and cobalt (0.030 ± 0.020 mg/kg) concentrations were lower than the reports for other colony of Chinstrap penguins, and essential elements as iron (26 ± 12 mg/kg), zinc (78.0 ± 5.3 mg/kg), and chromium (0.51 ± 0.27 mg/kg) were in the same range while Se (2.90 ± 0.65 mg/kg) content were the lowest reported. Mercury (0.43 ± 0.21 mg/kg), chromium (0.210 ± 0.060 mg/kg), and silver (0.083 ± 0.003 mg/kg) in chicks tended to be lower than in adults. Iron, cobalt, and arsenic concentrations in feathers found in this study were the lowest compared to measurements were in several penguin species in Antarctica. These results confirm to feathers like effective indicators for the trace elements incorporated in the penguins and it provide a data set which can adds to the baseline for bioindication studies using feathers.

Arima syndrome caused by CEP290 specific variant and accompanied with pathological cilium; clinical comparison with Joubert syndrome and its related diseases.

PubMed

Itoh, Masayuki; Ide, Shuhei; Iwasaki, Yuji; Saito, Takashi; Narita, Keishi; Dai, Hongmei; Yamakura, Shinji; Furue, Takeki; Kitayama, Hirotsugu; Maeda, Keiko; Takahashi, Eihiko; Matsui, Kiyoshi; Goto, Yu-Ichi; Takeda, Sen; Arima, Masataka

2018-04-01

Arima syndrome (AS) is a rare disease and its clinical features mimic those of Joubert syndrome or Joubert syndrome-related diseases (JSRD). Recently, we clarified the AS diagnostic criteria and its severe phenotype. However, genetic evidence of AS remains unknown. We explored causative genes of AS and compared the clinical and genetic features of AS with the other JSRD. We performed genetic analyses of 4 AS patients of 3 families with combination of whole-exome sequencing and Sanger sequencing. Furthermore, we studied cell biology with the cultured fibroblasts of 3 AS patients. All patients had a specific homozygous variant (c.6012-12T>A, p.Arg2004Serfs*7) or compound heterozygous variants (c.1711+1G>A; c.6012-12T>A, p.Gly570Aspfs*19;Arg2004Serfs*7) in centrosomal protein 290 kDa (CEP290) gene. These unique variants lead to abnormal splicing and premature termination. Morphological analysis of cultured fibroblasts from AS patients revealed a marked decrease of the CEP290-positive cell number with significantly longer cilium and naked and protruded ciliary axoneme without ciliary membrane into the cytoplasm. AS resulted in cilia dysfunction from centrosome disruption. The unique variant of CEP290 could be strongly linked to AS pathology. Here, we provided AS specific genetic evidence, which steers the structure and functions of centrosome that is responsible for normal ciliogenesis. This is the first report that has demonstrated the molecular basis of Arima syndrome. Copyright © 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

CC2D2A Is Mutated in Joubert Syndrome and Interacts with the Ciliopathy-Associated Basal Body Protein CEP290

PubMed Central

Gorden, Nicholas T.; Arts, Heleen H.; Parisi, Melissa A.; Coene, Karlien L.M.; Letteboer, Stef J.F.; van Beersum, Sylvia E.C.; Mans, Dorus A.; Hikida, Abigail; Eckert, Melissa; Knutzen, Dana; Alswaid, Abdulrahman F.; Özyurek, Hamit; Dibooglu, Sel; Otto, Edgar A.; Liu, Yangfan; Davis, Erica E.; Hutter, Carolyn M.; Bammler, Theo K.; Farin, Frederico M.; Dorschner, Michael; Topçu, Meral; Zackai, Elaine H.; Rosenthal, Phillip; Owens, Kelly N.; Katsanis, Nicholas; Vincent, John B.; Hildebrandt, Friedhelm; Rubel, Edwin W.; Raible, David W.; Knoers, Nine V.A.M.; Chance, Phillip F.; Roepman, Ronald; Moens, Cecilia B.; Glass, Ian A.; Doherty, Dan

2008-01-01

Joubert syndrome and related disorders (JSRD) are primarily autosomal-recessive conditions characterized by hypotonia, ataxia, abnormal eye movements, and intellectual disability with a distinctive mid-hindbrain malformation. Variable features include retinal dystrophy, cystic kidney disease, and liver fibrosis. JSRD are included in the rapidly expanding group of disorders called ciliopathies, because all six gene products implicated in JSRD (NPHP1, AHI1, CEP290, RPGRIP1L, TMEM67, and ARL13B) function in the primary cilium/basal body organelle. By using homozygosity mapping in consanguineous families, we identify loss-of-function mutations in CC2D2A in JSRD patients with and without retinal, kidney, and liver disease. CC2D2A is expressed in all fetal and adult tissues tested. In ciliated cells, we observe localization of recombinant CC2D2A at the basal body and colocalization with CEP290, whose cognate gene is mutated in multiple hereditary ciliopathies. In addition, the proteins can physically interact in vitro, as shown by yeast two-hybrid and GST pull-down experiments. A nonsense mutation in the zebrafish CC2D2A ortholog (sentinel) results in pronephric cysts, a hallmark of ciliary dysfunction analogous to human cystic kidney disease. Knockdown of cep290 function in sentinel fish results in a synergistic pronephric cyst phenotype, revealing a genetic interaction between CC2D2A and CEP290 and implicating CC2D2A in cilium/basal body function. These observations extend the genetic spectrum of JSRD and provide a model system for studying extragenic modifiers in JSRD and other ciliopathies. PMID:18950740

Trace elements in groundwater used for water supply in Latvia

NASA Astrophysics Data System (ADS)

Retike, Inga; Kalvans, Andis; Babre, Alise; Kalvane, Gunta; Popovs, Konrads

2014-05-01

Latvia is rich with groundwater resources of various chemical composition and groundwater is the main drinking source. Groundwater quality can be easily affected by pollution or overexploitation, therefore drinking water quality is an issue of high importance. Here the first attempt is made to evaluate the vast data base of trace element concentrations in groundwater collected by Latvian Environment, Geology and Meteorology Centre. Data sources here range from National monitoring programs to groundwater resources prospecting and research projects. First available historical records are from early 1960, whose quality is impossible to test. More recent systematic research has been focused on the agricultural impact on groundwater quality (Levins and Gosk, 2007). This research was mainly limited to Quaternary aquifer. Monitoring of trace elements arsenic, cadmium and lead was included in National groundwater monitoring program of Latvia in 2008 and 2009, but due to lack of funding the monitoring was suspended until 2013. As a result there are no comprehensive baseline studies regarding the trace elements concentration in groundwater. The aim of this study is to determine natural major and trace element concentration in aquifers mainly used for water supply in Latvia and to compare the results with EU potable water standards. A new overview of artesian groundwater quality will be useful for national and regional planning documents. Initial few characteristic traits of trace element concentration have been identified. For example, elevated fluorine, strontium and lithium content can be mainly associated with gypsum dissolution, but the highest barium concentrations are found in groundwaters with low sulphate content. The groundwater composition data including trace element concentrations originating from heterogeneous sources will be processed and analyzed as a part of a newly developed geologic and hydrogeological data management and modeling system with working name "GeoVipum". This study is supported by the European Social Fund project Nr.2013/0054/2DP/2.1.1.1.0/13/APIA/VIAA/007 in Latvia and European Social Fund Mobilitas grant No MJD309 in Estonia. Reference: Levins I., Gosk, E. 2007. Trace elements in groundwater as indicators of anthropogenic impact. Environmental Geology, 55, 285-290.

Content of selected elements in Boletus badius fruiting bodies growing in extremely polluted wastes.

PubMed

Mleczek, Mirosław; Siwulski, Marek; Mikołajczak, Patrycja; Gąsecka, Monika; Sobieralski, Krzysztof; Szymańczyk, Mateusz; Goliński, Piotr

2015-01-01

The aim of the study was to analyse levels of 17 trace elements and 5 major minerals in 11 Boletus badius fruiting bodies able to grow in extremely polluted waste (flotation tailings) and polluted soil in southern Poland. The presented data widen the limited literature data about the abilities of wild-growing mushroom species to grow on heavily contaminated substrates. Content of elements in waste, soil and mushrooms was analysed by flame atomic absorption spectrometry (FAAS) and cold vapour atomic absorption spectrometry (CVAAS - Hg). The industrial areas differed greatly as regards the content of elements in flotation tailings and soil; therefore differences in Ag, Ba, Cd, Co, Fe, Mo, Ni, Pb, Ca, K, Mg, Na and P accumulation in mushrooms were observed. The highest contents of elements in mushrooms were observed for: As, Al, Cu and Zn (86 ± 28, 549 ± 116, 341 ± 59 and 506 ± 40 mg kg(-1) dry matter, respectively). Calculated bioconcentration factor (BCF) values were higher than 1 for Al (15.1-16.9), Fe (10.6-24.4) and Hg (10.2-16.4) only. The main value of the presented results is the fact that one of the common wild-growing mushroom species was able to grow on flotation tailings containing over 22 g kg(-1) of As and, additionally, effective accumulation of other elements was observed. In view of the high content of the majority of analysed elements in fruiting bodies, edible mushrooms from such polluted areas are nonconsumable.

STS-116 Crew Portrait

NASA Technical Reports Server (NTRS)

2006-01-01

This is the STS-116 Crew Portrait. Pictured on the front row from left to right are: William Oefelein, pilot; Joan Higginbotham, mission specialist; and Mark Polansky, commander. On the back row, left to right, are: Robert Curbeam, Nicholas Patrick, Sunita Williams, and the European Space Agency's Christer Fuglesang, all mission specialists. Williams joined Expedition 14 in progress to serve as flight engineer aboard the International Space Station (ISS). Launched aboard the Space Shuttle Discovery on December 9, 2006, the seven delivered two high profile Marshall Space Flight Center (MSFC') payloads: The Lab-On-A Chip Application Development Portable Test System (LOCAD-PTS) and the Water Delivery System, a vital component of the Station's Oxygen Generation System. The primary mission objective was to deliver and install the P5 truss element. The P5 installation was conducted during the first of three space walks, and involved use of both the shuttle and station's robotic arms. The remainder of the mission included a major reconfiguration and activation of the ISS electrical and thermal control systems, as well as delivery of Zvezda Service Module debris panels, which will increase ISS protection from potential impacts of micro-meteorites and orbital debris.

Buckling Testing and Analysis of Honeycomb Sandwich Panel Arc Segments of a Full-Scale Fairing Barrel. Part 2; 6-Ply In-Autoclave Facesheets

NASA Technical Reports Server (NTRS)

Pineda, Evan J.; Meyers, David E.; Kosareo, Daniel N.; Zalewski, Bart F.; Dixon, Genevieve D.

2013-01-01

Four honeycomb sandwich panel types, representing 1/16th arc segments of a 10-m diameter barrel section of the Heavy Lift Launch Vehicle (HLLV), were manufactured and tested under the NASA Composites for Exploration program and the NASA Constellation Ares V program. Two configurations were chosen for the panels: 6-ply facesheets with 1.125 in. honeycomb core and 8-ply facesheets with 1.000 in. honeycomb core. Additionally, two separate carbon fiber/epoxy material systems were chosen for the facesheets: in-autoclave IM7/977-3 and out-of-autoclave T40-800b/5320-1. Smaller 3- by 5-ft panels were cut from the 1/16th barrel sections. These panels were tested under compressive loading at the NASA Langley Research Center (LaRC). Furthermore, linear eigenvalue and geometrically nonlinear finite element analyses were performed to predict the compressive response of each 3- by 5-ft panel. This manuscript summarizes the experimental and analytical modeling efforts pertaining to the panels composed of 6-ply, IM7/977-3 facesheets (referred to as Panels B-1 and B-2). To improve the robustness of the geometrically nonlinear finite element model, measured surface imperfections were included in the geometry of the model. Both the linear and nonlinear models yield good qualitative and quantitative predictions. Additionally, it was correctly predicted that the panel would fail in buckling prior to failing in strength. Furthermore, several imperfection studies were performed to investigate the influence of geometric imperfections, fiber angle misalignments, and three-dimensional (3-D) effects on the compressive response of the panel.

Buckling Testing and Analysis of Honeycomb Sandwich Panel Arc Segments of a Full-Scale Fairing Barrel Part 1: 8-Ply In-Autoclave Facesheets. Part 1; 8-Ply In-Autoclave Facesheets

NASA Technical Reports Server (NTRS)

Myers, David E.; Pineda, Evan J.; Zalewski, Bart F.; Kosareo, Daniel N.; Kellas, Sotiris

2013-01-01

Four honeycomb sandwich panels, representing 1/16th arc segments of a 10-m diameter barrel section of the heavy lift launch vehicle, were manufactured under the NASA Composites for Exploration program and the NASA Space Launch Systems program. Two configurations were chosen for the panels: 6-ply facesheets with 1.125 in. honeycomb core and 8-ply facesheets with 1.000 in. honeycomb core. Additionally, two separate carbon fiber/epoxy material systems were chosen for the facesheets: inautoclave IM7/977-3 and out-of-autoclave T40-800b/5320-1. Smaller 3.00- by 5.00-ft panels were cut from the 1/16th barrel sections. These panels were tested under compressive loading at the NASA Langley Research Center. Furthermore, linear eigenvalue and geometrically nonlinear finite element analysis was performed to predict the compressive response of the 3.00- by 5.00-ft panels. This manuscript summarizes the experimental and analytical modeling efforts pertaining to the panel composed of 8-ply, IM7/977-3 facesheets (referred to Panel A). To improve the robustness of the geometrically nonlinear finite element model, measured surface imperfections were included in the geometry of the model. Both the linear and nonlinear models yield good qualitative and quantitative predictions. Additionally, it was predicted correctly that the panel would fail in buckling prior to failing in strength. Furthermore, several imperfection studies were performed to investigate the influence of geometric imperfections, fiber misalignments, and three-dimensional (3 D) effects on the compressive response of the panel.

Establishing physico-chemical reference conditions in Mediterranean streams according to the European Water Framework Directive.

PubMed

Sánchez-Montoya, María del Mar; Arce, Maria Isabel; Vidal-Abarca, María Rosario; Suárez, María Luisa; Prat, Narcís; Gómez, Rosa

2012-05-01

Type-specific physico-chemical reference conditions are required for the assessment of ecological status in the Water Framework Directive context, similarly to the biological and hydro-morphological elements. This directive emphasises that natural variability of quality elements in high status (reference condition) needs to be quantified. Mediterranean streams often present a marked seasonal pattern in hydrological, biological and geochemical processes which could affect physico-chemical reference conditions. This study establishes general physico-chemical reference conditions (oxygenation, nutrient, salinity and acidification conditions) for different Mediterranean stream types. 116 potential reference sites located in 23 Mediterranean catchments in Spain were sampled in spring, summer and autumn in 2003. All sites were subjected to a screening method for the selection of reference sites in Mediterranean streams (Mediterranean Reference Criteria) and classified using a pre-established stream typology that establishes five different stream types (temporary streams, evaporite-calcareous at medium altitude, siliceous headwaters, calcareous headwaters and large watercourses). Reference conditions (reference value and reference threshold equivalents to high-good class boundary) were calculated using two different methods according to the availability of reference sites: the reference site 75th percentile approach of all reference sites and the 25th percentile of the population approach. The majority of the studied potential reference sites (76 out of 116) were selected as reference sites. Regarding type-specific reference conditions, only siliceous headwaters could be considered different from the rest of stream types because lower conductivity and pH. All reference stream types presented seasonal differences as regards some parameters, except for temporary streams due to the high natural variation of this stream type. For those parameters which presented seasonal differences in a specific stream type, the least restrictive values were proposed as reference conditions. Copyright © 2012 Elsevier Ltd. All rights reserved.

7 CFR 1150.116 - Nutrition education.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 9 2014-01-01 2013-01-01 true Nutrition education. 1150.116 Section 1150.116 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Order Definitions § 1150.116 Nutrition education. Nutrition education means those activities intended to...

7 CFR 1150.116 - Nutrition education.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 9 2013-01-01 2013-01-01 false Nutrition education. 1150.116 Section 1150.116 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Order Definitions § 1150.116 Nutrition education. Nutrition education means those activities intended to...

7 CFR 1150.116 - Nutrition education.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 9 2012-01-01 2012-01-01 false Nutrition education. 1150.116 Section 1150.116 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Order Definitions § 1150.116 Nutrition education. Nutrition education means those activities intended to...

7 CFR 1150.116 - Nutrition education.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 9 2011-01-01 2011-01-01 false Nutrition education. 1150.116 Section 1150.116 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Order Definitions § 1150.116 Nutrition education. Nutrition education means those activities intended to...

Origin discrimination of defatted pork via trace elements profiling, stable isotope ratios analysis, and multivariate statistical techniques.

PubMed

Park, Yu Min; Lee, Cheong Mi; Hong, Joon Ho; Jamila, Nargis; Khan, Naeem; Jung, Jong-Hyun; Jung, Young-Chul; Kim, Kyong Su

2018-09-01

This study verified the origin of 346 defatted Korean and non-Korean pork samples via trace elements profiling, and C and N stable isotope ratios analysis. The analyzed elements were 6 Li, 7 Li, 10 B, 11 B, 51 V , 50 Cr, 52 Cr, 53 Cr, 55 Mn, 58 Ni, 60 Ni, 59 Co, 63 Cu, 65 Cu, 64 Zn, 66 Zn, 69 Ga, 71 Ga, 75 As, 82 Se, 84 Sr, 86 Sr, 87 Sr, 88 Sr, 85 Rb, 94 Mo, 95 Mo, 97 Mo, 107 Ag, 109 Ag, 110 Cd, 111 Cd, 113 Cd, 112 Cd, 114 Cd, 116 Cd, 133 Cs, 206 Pb, 207 Pb, and 208 Pb. Content (mg/kg) of 51 V (0.012), 50 Cr (0.882), 75 As (0.017), 85 Rb (57.7), and 87 Sr (46.3) were high in Korean pork samples whereas 6 Li, 7 Li, 59 Co, 55 Mn, 58 Ni, 84 Sr, 86 Sr, 88 Sr, 111 Cd, and 133 Cs were found higher in non-Korean samples. The results of discriminant analysis showed that the trace elements content and stable isotope ratios were significant for the discrimination of geographical origins with a perfect discrimination rate of 100%. Copyright © 2018 Elsevier Ltd. All rights reserved.

Mapping cis-Regulatory Domains in the Human Genome UsingMulti-Species Conservation of Synteny

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahituv, Nadav; Prabhakar, Shyam; Poulin, Francis

2005-06-13

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A totalmore » of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains within these CBS we analyzed the prevalence and distribution of chromosomal aberrations leading to position effects (disruption of a genes regulatory environment), observing a clear bias not only for mapping onto CBS but also for longer CBS size. Our results provide a genome wide data set characterizing the regulatory domains of genes and the conserved regulatory elements within them.« less

33 CFR 165.930 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Des Plaines River located between mile marker 286.0 (Brandon Road Lock and Dam) and mile marker 290.0... Sanitary and Ship Canal. All U.S. waters of the Chicago Sanitary and Ship Canal between mile marker 290.0... (Main Branch) and North Branch Chicago River). (4) Chicago River (Main Branch). All U.S. waters of the...

Dicarboxylic acid transport in Bradyrhizobium japonicum: use of Rhizobium meliloti dct gene(s) to enhance nitrogen fixation.

PubMed Central

Birkenhead, K; Manian, S S; O'Gara, F

1988-01-01

A recombinant plasmid encoding Rhizobium meliloti sequences involved in dicarboxylic acid transport (plasmid pRK290:4:46) (E. Bolton, B. Higgisson, A. Harrington, and F. O'Gara, Arch. Microbiol. 144:142-146, 1986) was used to study the relationship between dicarboxylic acid transport and nitrogen fixation in Bradyrhizobium japonicum. The expression of the dct sequences on plasmid pRK290:4:46 in B. japonicum CJ1 resulted in increased growth rates in media containing dicarboxylic acids as the sole source of carbon. In addition, strain CJ1(pRK290:4:46) exhibited enhanced succinate uptake activity when grown on dicarboxylic acids under aerobic conditions. Under free-living nitrogen-fixing conditions, strain CJ1(pRK290:4:46) exhibited higher nitrogenase (acetylene reduction) activity compared with that of the wild-type strain. This increase in nitrogenase activity also correlated with an enhanced dicarboxylic acid uptake rate under these microaerobic conditions. The regulation of dicarboxylic acid transport by factors such as metabolic inhibitors and the presence of additional carbon sources was similar in both the wild-type and the engineered strains. The implications of increasing nitrogenase activity through alterations in the dicarboxylic acid transport system are discussed. PMID:3422072

CORROSION EXPERIENCE WITH ALUMINUM POWDER PRODUCTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Draley, J.E.; Ruther, W.E.; Greenberg, S.

1963-11-01

Extrusions of aluminum alloy powder products were obtained from several sources and evaluated for corrosion resistance to high-temperature (260-- 350 deg C) water. Several types of tubing impact-extruded by ALCOA were tested. The stronger tabing (M655) failed very rapidly. The weaker tubing suffered extensive localized surface attack and penetration of the corrosion attack along the extrusion direction after prolonged ( approximates 3 months) exposure to 290 deg C water. A precorrosion heat treatment was effective in reducing both types of attack on the weaker tubing. Armour Research Foundation supplied several types of tubing extraded through a bridge die. All tubesmore » failed on prolonged ( approximates 8 months) corrosion in 290 deg C water at the longitudinal bond lines. These lines were formed by the rejoining of the metal streams passing over the mandrel supports in the die during extrusion. Directly extruded tubing supplied by the Torrance Brass Company also failed on extended exposure to 290 deg C water. Many experimental rod extrusions (from Armour Research Foundation and Trefimetaux) exhibited corrosion resistance to static 290 deg C water equivalent to that of wrought alloys. The Trefimetaux specimens were also tested in rapidly flowing water at 315 deg C. Under these conditions a corrosion rate significantly faster than for the wrought alloy was measured. (auth)« less

14 CFR 1245.116 - Miscellaneous provisions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Miscellaneous provisions. 1245.116 Section 1245.116 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.116 Miscellaneous provisions. (a) Filing of...

14 CFR 1245.116 - Miscellaneous provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Miscellaneous provisions. 1245.116 Section 1245.116 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.116 Miscellaneous provisions. (a) Filing of...

40 CFR 116.1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Applicability. 116.1 Section 116.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.1 Applicability. This regulation designates hazardous substances under section 311(b)(2)(A...

7 CFR 1942.116 - Economic feasibility requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Economic feasibility requirements. 1942.116 Section 1942.116 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Facilities Projects § 1942.116 Economic feasibility requirements. All projects financed under this section...

7 CFR 1942.116 - Economic feasibility requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 13 2011-01-01 2009-01-01 true Economic feasibility requirements. 1942.116 Section 1942.116 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Facilities Projects § 1942.116 Economic feasibility requirements. All projects financed under this section...

7 CFR 1942.116 - Economic feasibility requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 13 2013-01-01 2013-01-01 false Economic feasibility requirements. 1942.116 Section 1942.116 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Facilities Projects § 1942.116 Economic feasibility requirements. All projects financed under this section...

7 CFR 1942.116 - Economic feasibility requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 13 2012-01-01 2012-01-01 false Economic feasibility requirements. 1942.116 Section 1942.116 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Facilities Projects § 1942.116 Economic feasibility requirements. All projects financed under this section...

7 CFR 1942.116 - Economic feasibility requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 13 2014-01-01 2013-01-01 true Economic feasibility requirements. 1942.116 Section 1942.116 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Facilities Projects § 1942.116 Economic feasibility requirements. All projects financed under this section...

40 CFR 116.1 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Applicability. 116.1 Section 116.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.1 Applicability. This regulation designates hazardous substances under section 311(b)(2)(A...

40 CFR 116.1 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Applicability. 116.1 Section 116.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.1 Applicability. This regulation designates hazardous substances under section 311(b)(2)(A...

Quantifying fluctuations of resting state networks using arterial spin labeling perfusion MRI

PubMed Central

Varma, Gopal; Scheidegger, Rachel; Alsop, David C

2015-01-01

Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) has been widely used to investigate spontaneous low-frequency signal fluctuations across brain resting state networks. However, BOLD only provides relative measures of signal fluctuations. Arterial Spin Labeling (ASL) MRI holds great potential for quantitative measurements of resting state network fluctuations. This study systematically quantified signal fluctuations of the large-scale resting state networks using ASL data from 20 healthy volunteers by separating them from global signal fluctuations and fluctuations caused by residual noise. Global ASL signal fluctuation was 7.59% ± 1.47% relative to the ASL baseline perfusion. Fluctuations of seven detected resting state networks vary from 2.96% ± 0.93% to 6.71% ± 2.35%. Fluctuations of networks and residual noise were 6.05% ± 1.18% and 6.78% ± 1.16% using 4-mm resolution ASL data applied with Gaussian smoothing kernel of 6mm. However, network fluctuations were reduced by 7.77% ± 1.56% while residual noise fluctuation was markedly reduced by 39.75% ± 2.90% when smoothing kernel of 12 mm was applied to the ASL data. Therefore, global and network fluctuations are the dominant structured noise sources in ASL data. Quantitative measurements of resting state networks may enable improved noise reduction and provide insights into the function of healthy and diseased brain. PMID:26661226

Quantifying fluctuations of resting state networks using arterial spin labeling perfusion MRI.

PubMed

Dai, Weiying; Varma, Gopal; Scheidegger, Rachel; Alsop, David C

2016-03-01

Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) has been widely used to investigate spontaneous low-frequency signal fluctuations across brain resting state networks. However, BOLD only provides relative measures of signal fluctuations. Arterial Spin Labeling (ASL) MRI holds great potential for quantitative measurements of resting state network fluctuations. This study systematically quantified signal fluctuations of the large-scale resting state networks using ASL data from 20 healthy volunteers by separating them from global signal fluctuations and fluctuations caused by residual noise. Global ASL signal fluctuation was 7.59% ± 1.47% relative to the ASL baseline perfusion. Fluctuations of seven detected resting state networks vary from 2.96% ± 0.93% to 6.71% ± 2.35%. Fluctuations of networks and residual noise were 6.05% ± 1.18% and 6.78% ± 1.16% using 4-mm resolution ASL data applied with Gaussian smoothing kernel of 6mm. However, network fluctuations were reduced by 7.77% ± 1.56% while residual noise fluctuation was markedly reduced by 39.75% ± 2.90% when smoothing kernel of 12 mm was applied to the ASL data. Therefore, global and network fluctuations are the dominant structured noise sources in ASL data. Quantitative measurements of resting state networks may enable improved noise reduction and provide insights into the function of healthy and diseased brain. © The Author(s) 2015.

Phase I dose-escalation and pharmacokinetic study (TED 11576) of cabazitaxel in Japanese patients with castration-resistant prostate cancer.

PubMed

Mukai, Hirofumi; Takahashi, Shunji; Nozawa, Masahiro; Onozawa, Yusuke; Miyazaki, Jun; Ohno, Keiji; Suzuki, Kazuhiro

2014-04-01

The purpose of the study is to analyze the pharmacokinetic (PK) profile of cabazitaxel and evaluate its safety and tolerability as a 1-h IV infusion every 3 weeks in Japanese patients with castration-resistant prostate cancer (CRPC). Seventeen patients were treated with cabazitaxel at doses of 20 and 25 mg/m(2) for PK analyses. Dose escalation was performed only in the absence of dose-limiting toxicity (DLT). The maximum tolerated dose (MTD) was the highest dose at which less than 33 % of the patients developed DLT. Cabazitaxel exhibited a triphasic elimination profile with a long terminal half-life of 116 ± 29.0 or 113 ± 28.0 h after IV infusion of 20 or 25 mg/m(2) cabazitaxel, respectively. The major differences in the PK parameters of cabazitaxel and docetaxel were cabazitaxel's fairly high clearance rate, representing approximately half the hepatic flow, and its large volume of distribution at steady-state conditions. No DLT was observed during Cycle 1. Mild-to-moderate hematological adverse events (AEs), including neutropenia, and other AEs typically associated with taxanes were observed; all AEs were manageable. Cabazitaxel at 25 mg/m(2) every 3 weeks was selected as the MTD in Japanese patients. The PK parameters of cabazitaxel in Japanese CRPC patients were comparable with those previously determined in Caucasian subjects. The safety and tolerability of cabazitaxel were also comparable in both ethnic populations.

Ultrareliable fault-tolerant control systems

NASA Technical Reports Server (NTRS)

Webster, L. D.; Slykhouse, R. A.; Booth, L. A., Jr.; Carson, T. M.; Davis, G. J.; Howard, J. C.

1984-01-01

It is demonstrated that fault-tolerant computer systems, such as on the Shuttles, based on redundant, independent operation are a viable alternative in fault tolerant system designs. The ultrareliable fault-tolerant control system (UFTCS) was developed and tested in laboratory simulations of an UH-1H helicopter. UFTCS includes asymptotically stable independent control elements in a parallel, cross-linked system environment. Static redundancy provides the fault tolerance. A polling is performed among the computers, with results allowing for time-delay channel variations with tight bounds. When compared with the laboratory and actual flight data for the helicopter, the probability of a fault was, for the first 10 hr of flight given a quintuple computer redundancy, found to be 1 in 290 billion. Two weeks of untended Space Station operations would experience a fault probability of 1 in 24 million. Techniques for avoiding channel divergence problems are identified.

An Integrated Computerized Triage System in the Emergency Department

PubMed Central

Aronsky, Dominik; Jones, Ian; Raines, Bill; Hemphill, Robin; Mayberry, Scott R; Luther, Melissa A; Slusser, Ted

2008-01-01

Emergency department (ED) triage is a fast-paced process that prioritizes the allocation of limited health care resources to patients in greatest need. This paper describes the experiences with an integrated, computerized triage application. The system exchanges information with other information systems, including the ED patient tracking board, the longitudinal electronic medical record, the computerized provider order entry, and the medication reconciliation application. The application includes decision support capabilities such as assessing the patient’s acuity level, age-dependent alerts for vital signs, and clinical reminders. The browser-based system utilizes the institution’s controlled vocabulary, improves data completeness and quality, such as compliance with capturing required data elements and screening questions, initiates clinical processes, such as pneumococcal vaccination ordering, and reminders to start clinical pathways, issues alerts for clinical trial eligibility, and facilitates various reporting needs. The system has supported the triage documentation of >290,000 pediatric and adult patients. PMID:18999190

Polarization splitter based on interference effects in all-solid photonic crystal fibers.

PubMed

Mao, Dong; Guan, Chunying; Yuan, Libo

2010-07-01

We propose a novel kind of polarization splitter in all-solid photonic crystal fibers based on the mode interference effects. Both the full-vector finite-element method and the semi-vector three-dimensional beam propagation method are employed to design and analyze the characteristics of the splitter. Numerical simulations show that x-polarized and y-polarized modes are split entirely along with 6.8 mm long propagation. An extinction ratio of more than 20 dB and a crosstalk of less than -20 dB are obtained within the wavelength range of 1.541-1.556 microm. The extinction ratio and the crosstalk at 1.55 microm are 28.9 and -29.0 dB for x polarization, while the extinction ratio and the crosstalk at 1.55 microm are 29.9 and -29.8 dB for y polarization, respectively.

40 CFR 428.116 - Pretreatment standards for new sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Pretreatment standards for new sources. 428.116 Section 428.116 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS RUBBER MANUFACTURING POINT SOURCE CATEGORY Latex Foam Subcategory § 428.116...

40 CFR 428.116 - Pretreatment standards for new sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pretreatment standards for new sources. 428.116 Section 428.116 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS RUBBER MANUFACTURING POINT SOURCE CATEGORY Latex Foam Subcategory § 428.116...

32 CFR 536.116 - Responsibilities as to claims arising overseas under international agreements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... under international agreements. 536.116 Section 536.116 National Defense Department of Defense... Under International Agreements § 536.116 Responsibilities as to claims arising overseas under international agreements. (a) Command claims services or other responsible JA offices within whose jurisdiction...

32 CFR 536.116 - Responsibilities as to claims arising overseas under international agreements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... under international agreements. 536.116 Section 536.116 National Defense Department of Defense... Under International Agreements § 536.116 Responsibilities as to claims arising overseas under international agreements. (a) Command claims services or other responsible JA offices within whose jurisdiction...

32 CFR 536.116 - Responsibilities as to claims arising overseas under international agreements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... under international agreements. 536.116 Section 536.116 National Defense Department of Defense... Under International Agreements § 536.116 Responsibilities as to claims arising overseas under international agreements. (a) Command claims services or other responsible JA offices within whose jurisdiction...

32 CFR 536.116 - Responsibilities as to claims arising overseas under international agreements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... under international agreements. 536.116 Section 536.116 National Defense Department of Defense... Under International Agreements § 536.116 Responsibilities as to claims arising overseas under international agreements. (a) Command claims services or other responsible JA offices within whose jurisdiction...

32 CFR 536.116 - Responsibilities as to claims arising overseas under international agreements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... under international agreements. 536.116 Section 536.116 National Defense Department of Defense... Under International Agreements § 536.116 Responsibilities as to claims arising overseas under international agreements. (a) Command claims services or other responsible JA offices within whose jurisdiction...

42 CFR 438.116 - Solvency standards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Solvency standards. 438.116 Section 438.116 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Enrollee Rights and Protections § 438.116 Solvency standards. (a...

9 CFR 116.5 - Reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Reports. 116.5 Section 116.5 Animals..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.5 Reports. (a) When required by the Administrator, reports containing accurate and complete information concerning...

9 CFR 116.5 - Reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Reports. 116.5 Section 116.5 Animals..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.5 Reports. (a) When required by the Administrator, reports containing accurate and complete information concerning...

9 CFR 116.5 - Reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Reports. 116.5 Section 116.5 Animals..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.5 Reports. (a) When required by the Administrator, reports containing accurate and complete information concerning...

9 CFR 116.5 - Reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Reports. 116.5 Section 116.5 Animals..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.5 Reports. (a) When required by the Administrator, reports containing accurate and complete information concerning...

Synthesis and Characterization of a New Benzoindole Derivative with Apoptotic Activity Against Colon Cancer Cells.

PubMed

Hajiaghaalipour, Fatemeh; Faraj, Fadhil L; Bagheri, Elham; Ali, Hapipah M; Abdulla, Mahmood Ameen; Majid, Nazia A

2017-01-01

Colorectal cancer is the third most common form of cancer in both men and women around the world. The chemistry and biological study of heterocyclic compounds have been an interesting area for a long time in pharmaceutical and medicinal chemistry. A new synthetic compound, 2-(1,1-dimethyl-1H-benzo[e]indol-2-yl)-3-((2-hydroxyphenyl)amino) acrylaldehyde, abbreviated as DBID, was prepared through the reaction of 2-(diformylmethylidene)-1,1- dimethylbenzo[e]indole with 2-aminophenol. The chemical structure of the synthesized compound was characterized by 1H NMR, 13C NMR and APT-NMR spectroscopy and confirmed by elemental analysis (CHN). The compound was screened for the antiproliferation effect against colorectal cancer cell line, HCT 116 and its possible mechanism of action was elucidated. To determine the IC50 value, the MTT assay was used and its apoptosisinducing effect was investigated. DBID inhibited the proliferation of HCT 116 cells with an IC50 of 9.32 µg/ml and significantly increased the levels of caspase -8, -9 and -3/7 in the treated cells compared to untreated cells. Apoptosis features in HCT 116 cell was detected in treated cells by using the AO/PI staining that confirmed that the cells had undergone remarkable morphological changes in apoptotic bodies. Furthermore, this changes in expression of caspase -8, -9 and -3 were confirmed by gene and protein quantification using RT-PCR and western blot analysis, respectively. The current study showed that the DBID compound has demonstrated chemotherapeutic activity which was evidenced by significant increases in the expression and activation of caspase and exploit the apoptotic signaling pathways to trigger cancer cell death. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

[Influence of trabecular microstructure modeling on finite element analysis of dental implant].

PubMed

Shen, M J; Wang, G G; Zhu, X H; Ding, X

2016-09-01

To analyze the influence of trabecular microstructure modeling on the biomechanical distribution of implant-bone interface with a three-dimensional finite element mandible model of trabecular structure. Dental implants were embeded in the mandibles of a beagle dog. After three months of the implant installation, the mandibles with dental implants were harvested and scaned by micro-CT and cone-beam CT. Two three-dimensional finite element mandible models, trabecular microstructure(precise model) and macrostructure(simplified model), were built. The values of stress and strain of implant-bone interface were calculated using the software of Ansys 14.0. Compared with the simplified model, the precise models' average values of the implant bone interface stress increased obviously and its maximum values did not change greatly. The maximum values of quivalent stress of the precise models were 80% and 110% of the simplified model and the average values were 170% and 290% of simplified model. The maximum and average values of equivalent strain of precise models were obviously decreased, and the maximum values of the equivalent effect strain were 17% and 26% of simplified model and the average ones were 21% and 16% of simplified model respectively. Stress and strain concentrations at implant-bone interface were obvious in the simplified model. However, the distributions of stress and strain were uniform in the precise model. The precise model has significant effect on the distribution of stress and strain at implant-bone interface.

The performance of moss, grass, and 1- and 2-year old spruce needles as bioindicators of contamination: a comparative study at the scale of the Czech Republic.

PubMed

Suchara, Ivan; Sucharova, Julie; Hola, Marie; Reimann, Clemens; Boyd, Rognvald; Filzmoser, Peter; Englmaier, Peter

2011-05-01

Moss (Pleurozium schreberi), grass (Avenella flexuosa), and 1- and 2-year old spruce (Picea abies) needles were collected over the territory of the Czech Republic at an average sample density of 1 site per 290km(2). The samples were analysed for 39 elements (Ag, Al, As, Ba, Be, Bi, Ca, Cd, Ce, Co, Cr, Cs, Cu, Fe, Ga, Hg, K, La, Li, Mg, Mn, Mo, Na, Nd, Ni, Pb, Pr, Rb, S, Sb, Se, Sn, Sr, Th, Tl, U, V, Y and Zn) using ICP-MS and ICP-AES techniques (the major nutrients Ca, K, Mg and Na were not analysed in moss). Moss showed by far the highest element concentrations for most elements. Exceptions were Ba (spruce), Mn (spruce), Mo (grass), Ni (spruce), Rb (grass) and S (grass). Regional distribution maps and spatial trend analysis were used to study the suitability of the four materials as bioindicators of anthropogenic contamination. The highly industrialised areas in the north-west and the far east of the country and several more local contamination sources were indicated in the distribution maps of one or several sample materials. At the scale of the whole country moss was the best indicator of known contamination sources. However, on a more local scale, it appeared that spruce needles were especially well suited for detection of urban contamination. Copyright © 2010 Elsevier B.V. All rights reserved.

He2-90'S APPEARANCE DECEIVES ASTRONOMERS

NASA Technical Reports Server (NTRS)

2002-01-01

Astronomers using NASA's Hubble Space Telescope have stumbled upon a mysterious object that is grudgingly yielding clues to its identity. A quick glance at the Hubble picture at top shows that this celestial body, called He2-90, looks like a young, dust-enshrouded star with narrow jets of material streaming from each side. But it's not. The object is classified as a planetary nebula, the glowing remains of a dying, lightweight star. But the Hubble observations suggest that it may not fit that classification, either. The Hubble astronomers now suspect that this enigmatic object may actually be a pair of aging stars masquerading as a single youngster. One member of the duo is a bloated red giant star shedding matter from its outer layers. This matter is then gravitationally captured in a rotating, pancake-shaped accretion disk around a compact partner, which is most likely a young white dwarf (the collapsed remnant of a sun-like star). The stars cannot be seen in the Hubble images because a lane of dust obscures them. The Hubble picture at top shows a centrally bright object with jets, appearing like strings of beads, emanating from both sides of center. (The other streaks of light running diagonally from He2-90 are artificial effects of the telescope's optical system.) Each jet possesses at least six bright clumps of gas, which are speeding along at rates estimated to be at least 375,000 miles an hour (600,000 kilometers an hour). These gaseous salvos are being ejected into space about every 100 years, and may be caused by periodic instabilities in He2-90's accretion disk. The jets from very young stars behave in a similar way. Deep images taken from terrestrial observatories show each jet extending at least 100,000 astronomical units (one astronomical unit equals the Earth-Sun distance, 93 million miles). The jets' relatively modest speed implies that one member of the duo is a white dwarf. Observations by the Compton Gamma-Ray Observatory, however, discovered a gamma-ray source in the vicinity of He2-90, suggesting that the companion may be a neutron star or a black hole (the compact corpses of dying, massive stars). But the jets from accretion disks around neutron stars or black holes travel at a few tenths the speed of light, much faster than the plodding pace of He2-90's jets. The Hubble astronomers are planning more observations to pinpoint the gamma-ray source to determine whether it is associated with He2-90. An accretion disk needs gravity to form. For gravity to create He2-90's disk, the pair of stars must reside at a cozy distance from each other: within about 10 astronomical units. Although the astronomers are uncertain about the details, they believe that magnetic fields associated with the accretion disk produce and constrict the pencil-thin jets seen in the Hubble image. The close-up Hubble photo at bottom shows a dark, flaring, disk-like structure [off-center] bisecting the bright light from the object. The disk is seen edge-on. Although too large to be an accretion disk, this dark, flaring disk may provide indirect proof of the other's existence. Most theories for producing jets require the presence of an accretion disk. The jets are seen streaming from both sides of the central object. The round, white objects at the lower left and upper right corners are two bright clumps of gas in the jets. The astronomers traced the jets to within 1,000 astronomical units of the central obscured star. The star ejected this jet material about 30 years ago. Scientists discovered this puzzling object while taking a census of planetary nebulae. They knew it had been classified as a dying, sun-like star. He2-90 is enshrouded in very hot (17,500 degrees Fahrenheit or 10,000 degrees Kelvin), glowing gas, a typical feature of planetary nebulae. And yet the disk and jets indicated the presence of an embryonic star. The mystified astronomers needed more information. Since embryonic stars are usually associated with cool, dense clouds of gas and dust, they used a ground-based radio telescope in Chile to look for evidence of such a cloud around He2-90. No such cloud was found, and He2-90's neighborhood showed no traces of developing stars. He2-90 lies about 8,000 light-years from Earth in the constellation Centaurus in the southern sky. The images were taken Sept 28, 1999 with the Wide Field and Planetary Camera 2. The images and results appear in the Aug. 1 issue of the Astrophysical Journal Letters. Credits: NASA, Raghvendra Sahai (NASA Jet Propulsion Laboratory), Lars-Ake Nyman (European Southern Observatory, Chile and Onsala Space Observatory, Sweden)

Rhenium Complex with Noninnocent Dioxolene Ligand: Combined Experimental and ab Initio Study of [(3,5-di-tert-Bu2C6H2O2)ReCl3(OPPh3)].

PubMed

Abramov, Pavel A; Gritsan, Nina P; Suturina, Elizaveta A; Bogomyakov, Artem S; Sokolov, Maxim N

2015-07-20

Reaction of [ReOCl3(PPh3)2] with 3,5-di-tert-butyl-1,2-benzoquinone (3,5-DTBQ) in hot toluene produces a new complex [(3,5-di-tert-Bu2C6H2O2)Re(OPPh3)Cl3] (1), which was isolated and characterized by elemental analysis, IR, UV-vis spectroscopy, and cyclic voltammetry. In order to clarify the charge state of rhenium and the coordinated dioxolene ligand, X-ray experiments at 150 and 290 K were carried out. The C-O, C-C, and Re-O bond distances at both 150 and 290 K fall between those for semiquinolate (3,5-DTBSQ) and catecholate (3,5-DTBCat) forms; an empirical "metrical oxidation state" of the dioxolene ligand was estimated to be -1.5. High-level ab initio calculations (SOC-CASSCF/NEVPT2) revealed a mixed valence nature of the triplet ground state of complex 1 corresponding to a superposition of the Re(IV)-SQ and Re(V)-cat forms. In agreement with the high-level ab initio and DFT calculations, the temperature dependence of the magnetic susceptibility (5-300 K) is well described in the assumption of the triplet ground state, with the anomalously large zero-field splitting (ZFS) arising from the spin-orbit coupling. According to the ab initio calculations, all absorption bands in the visible region of the electronic absorptions spectrum are assigned to the LMCT bands, with significant contribution of the intraligand transition in the most intense band at 555 nm.

32 CFR 219.116 - General requirements for informed consent.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false General requirements for informed consent. 219.116 Section 219.116 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.116 General requirements for informed...

40 CFR 89.116 - Engine families.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Engine families. 89.116 Section 89.116... Provisions § 89.116 Engine families. (a) A manufacturer's product line is divided into engine families that... life periods. (b) The following characteristics distinguish engine families: (1) Fuel; (2) Cooling...

40 CFR 116.2 - Abbreviations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Abbreviations. 116.2 Section 116.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.2 Abbreviations. ppm=parts per million mg=milligram(s) kg=kilogram(s) mg/l=milligrams(s) per...

7 CFR 1.16 - Extension of administrative deadlines.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Extension of administrative deadlines. 1.16 Section 1.16 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.16 Extension of administrative deadlines. (a) In unusual circumstances as specified in this section...

40 CFR 405.116 - Pretreatment standards for new sources.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for new sources. 405.116 Section 405.116 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS DAIRY PRODUCTS PROCESSING POINT SOURCE CATEGORY Condensed Whey Subcategory § 405.116...

40 CFR 81.116 - Northern Missouri Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Quality Control Region. 81.116 Section 81.116 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.116 Northern Missouri Intrastate Air Quality Control Region. The Northern Missouri Intrastate Air Quality Control Region consists of the territorial area encompassed by the...

40 CFR 81.116 - Northern Missouri Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Quality Control Region. 81.116 Section 81.116 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.116 Northern Missouri Intrastate Air Quality Control Region. The Northern Missouri Intrastate Air Quality Control Region consists of the territorial area encompassed by the...

45 CFR 400.116 - Service for unaccompanied minors.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Service for unaccompanied minors. 400.116 Section 400.116 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Child Welfare Services § 400.116 Service for unaccompanied minors. (a) A State must provide...

46 CFR 116.510 - Embarkation stations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Embarkation stations. 116.510 Section 116.510 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... and Embarkation Station Requirements § 116.510 Embarkation stations. (a) A vessel must have a least...

46 CFR 116.510 - Embarkation stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Embarkation stations. 116.510 Section 116.510 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150... and Embarkation Station Requirements § 116.510 Embarkation stations. (a) A vessel must have a least...

40 CFR 116.2 - Abbreviations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Abbreviations. 116.2 Section 116.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.2 Abbreviations. ppm=parts per million mg=milligram(s) kg=kilogram(s) mg/l=milligrams(s) per...

40 CFR 116.2 - Abbreviations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Abbreviations. 116.2 Section 116.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.2 Abbreviations. ppm=parts per million mg=milligram(s) kg=kilogram(s) mg/l=milligrams(s) per...

40 CFR 89.116 - Engine families.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Engine families. 89.116 Section 89.116... Provisions § 89.116 Engine families. (a) A manufacturer's product line is divided into engine families that... life periods. (b) The following characteristics distinguish engine families: (1) Fuel; (2) Cooling...

46 CFR 116.520 - Emergency evacuation plan.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Emergency evacuation plan. 116.520 Section 116.520... ARRANGEMENT Escape and Embarkation Station Requirements § 116.520 Emergency evacuation plan. The owner or managing operator shall prepare an evacuation plan that must: (a) Identify possible casualties involving...

46 CFR 116.520 - Emergency evacuation plan.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Emergency evacuation plan. 116.520 Section 116.520... ARRANGEMENT Escape and Embarkation Station Requirements § 116.520 Emergency evacuation plan. The owner or managing operator shall prepare an evacuation plan that must: (a) Identify possible casualties involving...

46 CFR 116.520 - Emergency evacuation plan.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Emergency evacuation plan. 116.520 Section 116.520... ARRANGEMENT Escape and Embarkation Station Requirements § 116.520 Emergency evacuation plan. The owner or managing operator shall prepare an evacuation plan that must: (a) Identify possible casualties involving...

46 CFR 116.520 - Emergency evacuation plan.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Emergency evacuation plan. 116.520 Section 116.520... ARRANGEMENT Escape and Embarkation Station Requirements § 116.520 Emergency evacuation plan. The owner or managing operator shall prepare an evacuation plan that must: (a) Identify possible casualties involving...

42 CFR 136.116 - Reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Reports. 136.116 Section 136.116 Public Health... and Services § 136.116 Reports. In addition to the reporting and information requirements provided in... Federal financial assistance shall make such reports and information available to the Indian people served...

42 CFR 136.116 - Reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Reports. 136.116 Section 136.116 Public Health... and Services § 136.116 Reports. In addition to the reporting and information requirements provided in... Federal financial assistance shall make such reports and information available to the Indian people served...

42 CFR 136.116 - Reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Reports. 136.116 Section 136.116 Public Health... and Services § 136.116 Reports. In addition to the reporting and information requirements provided in... Federal financial assistance shall make such reports and information available to the Indian people served...

28 CFR 0.116 - Board of Immigration Appeals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Board of Immigration Appeals. 0.116 Section 0.116 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Executive Office for Immigration Review § 0.116 Board of Immigration Appeals. The Board of Immigration...

Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.

PubMed

Sheridan, P L; Schorpp, M; Voz, M L; Jones, K A

1995-03-03

We have isolated a human cDNA clone encoding HIP116, a protein that binds to the SPH repeats of the SV40 enhancer and to the TATA/inhibitor region of the human immunodeficiency virus (HIV)-1 promoter. The predicted HIP116 protein is related to the yeast SNF2/SWI2 transcription factor and to other members of this extended family and contains seven domains similar to those found in the vaccinia NTP1 ATPase. Interestingly, HIP116 also contains a C3HC4 zinc-binding motif (RING finger) interspersed between the ATPase motifs in an arrangement similar to that found in the yeast RAD5 and RAD16 proteins. The HIP116 amino terminus is unique among the members of this family, and houses a specific DNA-binding domain. Antiserum raised against HIP116 recognizes a 116-kDa nuclear protein in Western blots and specifically supershifts SV40 and HIV-1 protein-DNA complexes in gel shift experiments. The binding site for HIP116 on the SV40 enhancer directly overlaps the site for TEF-1, and like TEF-1, binding of HIP116 to the SV40 enhancer is destroyed by mutations that inhibit SPH enhancer activity in vivo. Purified fractions of HIP116 display strong ATPase activity that is preferentially stimulated by SPH DNA and can be inhibited specifically by antibodies to HIP116. These findings suggest that HIP116 might affect transcription, directly or indirectly, by acting as a DNA binding site-specific ATPase.

DOD Financial Management: Continued Actions Needed to Address Congressional Committee Panel Recommendations

DTIC Science & Technology

2015-09-01

which was intended to fundamentally transform DOD’s financial management operations and achieve clean financial 12GAO-15-290. 13GAO-15-290. 14Pub...Actions to Implement the Panel on Defense Financial Management and Auditability Reform Recommendations valuations for these assets. For example, DOD’s...governance, the department is managing its business systems, including ERP systems, as portfolios of investments . The goal is to aggregate data from

34 CFR 668.116 - Hearing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false Hearing. 668.116 Section 668.116 Education Regulations... Program Review Determinations § 668.116 Hearing. (a) A hearing is a process conducted by the hearing official whereby an orderly presentation of arguments and evidence is made by the parties. (b) The hearing...

45 CFR 46.116 - General requirements for informed consent.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false General requirements for informed consent. 46.116 Section 46.116 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.116 General requirements...

45 CFR 46.116 - General requirements for informed consent.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false General requirements for informed consent. 46.116 Section 46.116 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.116 General requirements...

45 CFR 46.116 - General requirements for informed consent.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false General requirements for informed consent. 46.116 Section 46.116 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.116 General requirements...

29 CFR 102.116 - Signature of orders.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false Signature of orders. 102.116 Section 102.116 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8 Certification and Signature of Documents § 102.116 Signature of orders. The executive secretary or the associate executive...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 264.116 - Survey plat.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Survey plat. 264.116 Section 264.116...-Closure § 264.116 Survey plat. No later than the submission of the certification of closure of each... authority with jurisdiction over local land use, and to the Regional Administrator, a survey plat indicating...

40 CFR 264.116 - Survey plat.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Survey plat. 264.116 Section 264.116...-Closure § 264.116 Survey plat. No later than the submission of the certification of closure of each... authority with jurisdiction over local land use, and to the Regional Administrator, a survey plat indicating...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 264.116 - Survey plat.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Survey plat. 264.116 Section 264.116...-Closure § 264.116 Survey plat. No later than the submission of the certification of closure of each... authority with jurisdiction over local land use, and to the Regional Administrator, a survey plat indicating...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 264.116 - Survey plat.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Survey plat. 264.116 Section 264.116...-Closure § 264.116 Survey plat. No later than the submission of the certification of closure of each... authority with jurisdiction over local land use, and to the Regional Administrator, a survey plat indicating...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 265.116 - Survey plat.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Survey plat. 265.116 Section 265.116... and Post-Closure § 265.116 Survey plat. No later than the submission of the certification of closure..., or the authority with jurisdiction over local land use, and to the Regional Administrator, a survey...

40 CFR 264.116 - Survey plat.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Survey plat. 264.116 Section 264.116...-Closure § 264.116 Survey plat. No later than the submission of the certification of closure of each... authority with jurisdiction over local land use, and to the Regional Administrator, a survey plat indicating...

42 CFR 433.116 - FFP for operation of mechanized claims processing and information retrieval systems.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and information retrieval systems. 433.116 Section 433.116 Public Health CENTERS FOR MEDICARE... FISCAL ADMINISTRATION Mechanized Claims Processing and Information Retrieval Systems § 433.116 FFP for operation of mechanized claims processing and information retrieval systems. (a) Subject to paragraph (j) of...

42 CFR 433.116 - FFP for operation of mechanized claims processing and information retrieval systems.

Code of Federal Regulations, 2013 CFR

2013-10-01

... and information retrieval systems. 433.116 Section 433.116 Public Health CENTERS FOR MEDICARE... FISCAL ADMINISTRATION Mechanized Claims Processing and Information Retrieval Systems § 433.116 FFP for operation of mechanized claims processing and information retrieval systems. (a) Subject to paragraph (j) of...

42 CFR 433.116 - FFP for operation of mechanized claims processing and information retrieval systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

... and information retrieval systems. 433.116 Section 433.116 Public Health CENTERS FOR MEDICARE... FISCAL ADMINISTRATION Mechanized Claims Processing and Information Retrieval Systems § 433.116 FFP for operation of mechanized claims processing and information retrieval systems. (a) Subject to paragraph (j) of...

42 CFR 433.116 - FFP for operation of mechanized claims processing and information retrieval systems.

Code of Federal Regulations, 2012 CFR

2012-10-01

... and information retrieval systems. 433.116 Section 433.116 Public Health CENTERS FOR MEDICARE... FISCAL ADMINISTRATION Mechanized Claims Processing and Information Retrieval Systems § 433.116 FFP for operation of mechanized claims processing and information retrieval systems. (a) Subject to paragraph (j) of...

46 CFR 116.970 - Protection against hot piping.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Protection against hot piping. 116.970 Section 116.970 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Rails and Guards § 116.970 Protection against hot piping. Piping, including valves, pipe fittings...

46 CFR 116.970 - Protection against hot piping.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Protection against hot piping. 116.970 Section 116.970 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Rails and Guards § 116.970 Protection against hot piping. Piping, including valves, pipe fittings...

46 CFR 116.970 - Protection against hot piping.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Protection against hot piping. 116.970 Section 116.970 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Rails and Guards § 116.970 Protection against hot piping. Piping, including valves, pipe fittings...

46 CFR 116.970 - Protection against hot piping.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Protection against hot piping. 116.970 Section 116.970 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Rails and Guards § 116.970 Protection against hot piping. Piping, including valves, pipe fittings...

46 CFR 116.970 - Protection against hot piping.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Protection against hot piping. 116.970 Section 116.970 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Rails and Guards § 116.970 Protection against hot piping. Piping, including valves, pipe fittings...

42 CFR 435.116 - Pregnant women.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 4 2013-10-01 2013-10-01 false Pregnant women. 435.116 Section 435.116 Public..., AND AMERICAN SAMOA Mandatory Coverage Mandatory Coverage of Pregnant Women, Children Under 19, and Newborn Children § 435.116 Pregnant women. (a) Basis. This section implements sections 1902(a)(10)(A)(i...

42 CFR 435.116 - Pregnant women.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 4 2014-10-01 2014-10-01 false Pregnant women. 435.116 Section 435.116 Public..., AND AMERICAN SAMOA Mandatory Coverage Mandatory Coverage of Pregnant Women, Children Under 19, and Newborn Children § 435.116 Pregnant women. (a) Basis. This section implements sections 1902(a)(10)(A)(i...

21 CFR 133.116 - Low sodium cheddar cheese.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Low sodium cheddar cheese. 133.116 Section 133.116... FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.116 Low sodium cheddar cheese. Low sodium cheddar cheese is the food...

21 CFR 133.116 - Low sodium cheddar cheese.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Low sodium cheddar cheese. 133.116 Section 133.116... FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.116 Low sodium cheddar cheese. Low sodium cheddar cheese is the food...

40 CFR 116.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Definitions. 116.3 Section 116.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.3 Definitions. As used in this part, all terms shall have the meaning defined in the Act and...

40 CFR 116.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Definitions. 116.3 Section 116.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS DESIGNATION OF HAZARDOUS SUBSTANCES § 116.3 Definitions. As used in this part, all terms shall have the meaning defined in the Act and...

23 CFR 636.116 - What organizational conflict of interest requirements apply to design-build projects?

Code of Federal Regulations, 2011 CFR

2011-04-01

... apply to design-build projects? 636.116 Section 636.116 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.116 What organizational conflict of interest requirements apply to design-build projects? (a) State...

23 CFR 636.116 - What organizational conflict of interest requirements apply to design-build projects?

Code of Federal Regulations, 2014 CFR

2014-04-01

... apply to design-build projects? 636.116 Section 636.116 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.116 What organizational conflict of interest requirements apply to design-build projects? (a) State...

23 CFR 636.116 - What organizational conflict of interest requirements apply to design-build projects?

Code of Federal Regulations, 2012 CFR

2012-04-01

... apply to design-build projects? 636.116 Section 636.116 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.116 What organizational conflict of interest requirements apply to design-build projects? (a) State...

23 CFR 636.116 - What organizational conflict of interest requirements apply to design-build projects?

Code of Federal Regulations, 2013 CFR

2013-04-01

... apply to design-build projects? 636.116 Section 636.116 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.116 What organizational conflict of interest requirements apply to design-build projects? (a) State...

9 CFR 116.7 - Test records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Test records. 116.7 Section 116.7..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.7 Test records. Detailed records of all tests conducted on each serial and each subserial shall be maintained by the...

9 CFR 116.7 - Test records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Test records. 116.7 Section 116.7..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.7 Test records. Detailed records of all tests conducted on each serial and each subserial shall be maintained by the...

20 CFR 632.116 - Conflict of interest.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conflict of interest. 632.116 Section 632.116... EMPLOYMENT AND TRAINING PROGRAMS Prevention of Fraud and Program Abuse § 632.116 Conflict of interest. (a) No... contractor shall avoid personal and organizational conflict of interest in awarding financial assistance and...

9 CFR 116.6 - Animal records.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal records...

9 CFR 116.6 - Animal records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal records...

9 CFR 116.6 - Animal records.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal records...