Nd3Ge1.18In0.82 and Sm3Ge1.33In0.67 - New ternary indides with La3GeIn type structure

NASA Astrophysics Data System (ADS)

Kravets, Oksana; Nychyporuk, Galyna; Muts, Ihor; Hlukhyy, Viktor; Pöttgen, Rainer; Zaremba, Vasyl'

2014-06-01

New indides, Nd3Ge1.18In0.82 and Sm3Ge1.33In0.67, were synthesized from the elements by arc-melting and subsequent annealing at 870 K. Single crystals were grown through special annealing procedures in sealed tantalum tubes in a resistance furnace. Both compounds were investigated on the basis of X-ray powder and single crystal data: La3GeIn type structure, Pearson code tI80, space group I4/mcm; a = 1200.1(1), c = 1562.8(1) pm, wR2 = 0.0781, 716 F2 values, 34 variables for Nd3Ge1.18In0.82 and a = 1184.7(2), c = 1537.0(3) pm, wR2 = 0.0305, 911 F2 values, 34 variables for Sm3Ge1.33In0.67. The crystal chemistry in Nd3Ge1.18In0.82 is discussed from a geometrical point of view and in terms of LMTO band structure calculations.

Investigation to synthesis more isotopes of superheavy nuclei Z = 118

NASA Astrophysics Data System (ADS)

Manjunatha, H. C.; Sridhar, K. N.

2018-07-01

We have studied the α-decay properties of superheavy nuclei Z = 118 in the range 275 ≤ A ≤ 325. Most of the predicted, unknown nuclei in the range 291 ≤ A ≤ 301 were found to have α-decay chains. Of these the nuclei 293-301118 were found to have long half-lives and hence could be sufficient to detect them if synthesized in a laboratory. Fusion barries for different projectile-target combinations to synthesis superheavy nuclei Z = 118 are studied and are also represented in simple relations. We have also studied the evaporation residue cross section, compound nucleus formation probability (PCN) and survival probability (PSurv) of different projectile-target combinations to synthesis superheavy element Z = 118. The selected most probable projectile-target combinations are Ca+Cf, Ti+Cm, Sc+Bk, V+Am, Cr+Pu, Fe+U, Mn+Np, Ni+Th and Kr+Pb. We have formulated simple relations for maximum evaporation residue cross sections and its corresponding energies. This helps to identify the projectile-target combinations quickly. Hence, we have identified the most probable projectile-target combinations to synthesis these superheavy nuclei. We hope that our predictions may be a guide for the future experiments in the synthesis of more isotopes of superheavy nuclei Z = 118.

Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.

PubMed

Kahn, Tatyana G; Dorafshan, Eshagh; Schultheis, Dorothea; Zare, Aman; Stenberg, Per; Reim, Ingolf; Pirrotta, Vincenzo; Schwartz, Yuri B

2016-12-01

Polycomb Group (PcG) proteins are epigenetic repressors essential for control of development and cell differentiation. They form multiple complexes of which PRC1 and PRC2 are evolutionary conserved and obligatory for repression. The targeting of PRC1 and PRC2 is poorly understood and was proposed to be hierarchical and involve tri-methylation of histone H3 (H3K27me3) and/or monoubiquitylation of histone H2A (H2AK118ub). Here, we present a strict test of this hypothesis using the Drosophila model. We discover that neither H3K27me3 nor H2AK118ub is required for targeting PRC complexes to Polycomb Response Elements (PREs). We find that PRC1 can bind PREs in the absence of PRC2 but at many PREs PRC2 requires PRC1 to be targeted. We show that one role of H3K27me3 is to allow PcG complexes anchored at PREs to interact with surrounding chromatin. In contrast, the bulk of H2AK118ub is unrelated to PcG repression. These findings radically change our view of how PcG repression is targeted and suggest that PRC1 and PRC2 can communicate independently of histone modifications. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Chemical experiments with superheavy elements.

PubMed

Türler, Andreas

2010-01-01

Unnoticed by many chemists, the Periodic Table of the Elements has been extended significantly in the last couple of years and the 7th period has very recently been completed with eka-Rn (element 118) currently being the heaviest element whose synthesis has been reported. These 'superheavy' elements (also called transactinides with atomic number > or = 104 (Rf)) have been artificially synthesized in fusion reactions at accelerators in minute quantities of a few single atoms. In addition, all isotopes of the transactinide elements are radioactive and decay with rather short half-lives. Nevertheless, it has been possible in some cases to investigate experimentally chemical properties of transactinide elements and even synthesize simple compounds. The experimental investigation of superheavy elements is especially intriguing, since theoretical calculations predict significant deviations from periodic trends due to the influence of strong relativistic effects. In this contribution first experiments with hassium (Hs, atomic number 108), copernicium (Cn, atomic number 112) and element 114 (eka-Pb) are reviewed.

High-mast light poles anchor nut loosening in Alaska : an investigation of field monitoring and finite-element analysis.

DOT National Transportation Integrated Search

2014-09-01

High mast lighting poles (HMLPs) are tall, roadside structures effective for lighting large areas of highways and intersections. The Alaska Department of Transportation : and Public Facilities (AKDOT&PF) maintains 118 such poles in the greater Anchor...

MOLECULAR MECHANISM OF HUMAN NRF2 ACTIVATION AND DEGRADATION: ROLE OF SEQUENTIAL PHOSPHORYLATION BY PROTEIN KINASE CK2

PubMed Central

Pi, Jingbo; Bai, Yushi; Reece, Jeffrey M.; Williams, Jason; Liu, Dianxin; Freeman, Michael L.; Fahl, William E.; Shugar, David; Liu, Jie; Qu, Wei; Collins, Sheila; Waalkes, Michael P.

2007-01-01

Nrf2 is a key transcription factor in the cellular response to oxidative stress. In this study we first identify two phosphorylated forms of endogenous human Nrf2 after chemically-induced oxidative stress and provide evidence that protein kinase CK2-mediated sequential phosphorylation plays potential role in Nrf2 activation and degradation. Human Nrf2 has a predicted molecular mass of 66 kDa. However, immunoblots showed that two bands at 98 and 118 kDa, which are identified as phosphorylated forms, are increased in response to Nrf2 inducers. In addition, human Nrf2 was found to be a substrate for CK2 which mediated two steps of phosphorylation, resulting in two forms of Nrf2 migrating with differing Mr at 98 kDa (Nrf2–98) and 118 kDa (Nrf2–118). Our results support a role in which calmodulin binding regulates CK2 activity, in that cold (25 °C) in Ca2+-free media (cold/Ca2+-free) decreased both cellular calcium levels and CK2-calmodulin binding and induced Nrf2–118 formation, the latter of which was prevented by CK2 specific inhibitors. Gel-shift assays showed that the Nrf2–118 generated under cold/Ca2+-free conditions does not bind to the antioxidant response element, indicating that Nrf2–98 has transcriptional activity. In contrast, Nrf2–118 is more susceptible to degradation. These results provide evidence for phosphorylation by CK2 as a critical controlling factor in Nrf2-mediated cellular antioxidant response. PMID:17512459

Molecular characterization of the sweet potato peroxidase SWPA4 promoter which responds to abiotic stresses and pathogen infection.

PubMed

Ryu, Sun-Hwa; Kim, Yun-Hee; Kim, Cha Young; Park, Soo-Young; Kwon, Suk-Yoon; Lee, Haeng-Soon; Kwak, Sang-Soo

2009-04-01

Previously, the swpa4 peroxidase gene has been shown to be inducible by a variety of abiotic stresses and pathogenic infections in sweet potato (Ipomoea batatas). To elucidate its regulatory mechanism at the transcriptional level under various stress conditions, we isolated and characterized the promoter region (2374 bp) of swpa4 (referred to as SWPA4). We performed a transient expression assay in tobacco protoplasts with deletions from the 5'-end of SWPA4 promoter fused to the beta-glucuronidase (GUS) reporter gene. The -1408 and -374 bp deletions relative to the transcription start site (+1) showed 8 and 4.5 times higher GUS expression than the cauliflower mosaic virus 35S promoter, respectively. In addition, transgenic tobacco plants expressing GUS under the control of -2374, -1408 or -374 bp region of SWPA4 promoter were generated and studied in various tissues under abiotic stresses and pathogen infection. Gel mobility shift assays revealed that nuclear proteins from sweet potato cultured cells specifically interacted with 60-bp fragment (-178/-118) in -374 bp promoter region. In silico analysis indicated that four kinds of cis-acting regulatory sequences, reactive oxygen species-related element activator protein 1 (AP1), CCAAT/enhancer-binding protein alpha element, ethylene-responsive element (ERE) and heat-shock element, are present in the -60 bp region (-178/-118), suggesting that the -60 bp region might be associated with stress inducibility of the SWPA4 promoter.

Actinide targets for the synthesis of super-heavy elements

DOE PAGES

Roberto, J.; Alexander, Charles W.; Boll, Rose Ann; ...

2015-06-18

Since 2000, six new super-heavy elements with atomic numbers 113 through 118 have been synthesized in hot fusion reactions of 48Ca beams on actinide targets. These target materials, including 242Pu, 244Pu, 243Am, 245Cm, 248Cm, 249Cf, and 249Bk, are available in very limited quantities and require specialized production and processing facilities resident in only a few research centers worldwide. This report describes the production and chemical processing of heavy actinide materials for super-heavy element research, current availabilities of these materials, and related target fabrication techniques. The impact of actinide materials in super-heavy element discovery is reviewed, and strategies for enhancing themore » production of rare actinides including 249Bk, 251Cf, and 254Es are described.« less

Explicit Trace Inequalities for Isogeometric Analysis and Parametric Hexahedral Finite Elements

DTIC Science & Technology

2011-05-01

Computational Mechanics, 43:3– 37, 2008. [6] Y Bazilevs, L Beirao da Veiga , J A Cottrell, T J R Hughes, and G Sangalli. Isoge- ometric analysis... Veiga , A Buffa, J Rivas, and G Sangalli. Some estimates for h − p − k refinement in isogeometric analysis. Numerische Mathematik, 118:271–305, 2011

Development of a core Clostridium thermocellum kinetic metabolic model consistent with multiple genetic perturbations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dash, Satyakam; Khodayari, Ali; Zhou, Jilai

Background. Clostridium thermocellum is a Gram-positive anaerobe with the ability to hydrolyze and metabolize cellulose into biofuels such as ethanol, making it an attractive candidate for consolidated bioprocessing (CBP). At present, metabolic engineering in C. thermocellum is hindered due to the incomplete description of its metabolic repertoire and regulation within a predictive metabolic model. Genome-scale metabolic (GSM) models augmented with kinetic models of metabolism have been shown to be effective at recapitulating perturbed metabolic phenotypes. Results. In this effort, we first update a second-generation genome-scale metabolic model (iCth446) for C. thermocellum by correcting cofactor dependencies, restoring elemental and charge balances,more » and updating GAM and NGAM values to improve phenotype predictions. The iCth446 model is next used as a scaffold to develop a core kinetic model (k-ctherm118) of the C. thermocellum central metabolism using the Ensemble Modeling (EM) paradigm. Model parameterization is carried out by simultaneously imposing fermentation yield data in lactate, malate, acetate, and hydrogen production pathways for 19 measured metabolites spanning a library of 19 distinct single and multiple gene knockout mutants along with 18 intracellular metabolite concentration data for a Δgldh mutant and ten experimentally measured Michaelis–Menten kinetic parameters. Conclusions. The k-ctherm118 model captures significant metabolic changes caused by (1) nitrogen limitation leading to increased yields for lactate, pyruvate, and amino acids, and (2) ethanol stress causing an increase in intracellular sugar phosphate concentrations (~1.5-fold) due to upregulation of cofactor pools. Robustness analysis of k-ctherm118 alludes to the presence of a secondary activity of ketol-acid reductoisomerase and possible regulation by valine and/or leucine pool levels. In addition, cross-validation and robustness analysis allude to missing elements in k-ctherm118 and suggest additional experiments to improve kinetic model prediction fidelity. Overall, the study quantitatively assesses the advantages of EM-based kinetic modeling towards improved prediction of C. thermocellum metabolism and develops a predictive kinetic model which can be used to design biofuel-overproducing strains.« less

Development of a core Clostridium thermocellum kinetic metabolic model consistent with multiple genetic perturbations

DOE PAGES

Dash, Satyakam; Khodayari, Ali; Zhou, Jilai; ...

2017-05-02

Background. Clostridium thermocellum is a Gram-positive anaerobe with the ability to hydrolyze and metabolize cellulose into biofuels such as ethanol, making it an attractive candidate for consolidated bioprocessing (CBP). At present, metabolic engineering in C. thermocellum is hindered due to the incomplete description of its metabolic repertoire and regulation within a predictive metabolic model. Genome-scale metabolic (GSM) models augmented with kinetic models of metabolism have been shown to be effective at recapitulating perturbed metabolic phenotypes. Results. In this effort, we first update a second-generation genome-scale metabolic model (iCth446) for C. thermocellum by correcting cofactor dependencies, restoring elemental and charge balances,more » and updating GAM and NGAM values to improve phenotype predictions. The iCth446 model is next used as a scaffold to develop a core kinetic model (k-ctherm118) of the C. thermocellum central metabolism using the Ensemble Modeling (EM) paradigm. Model parameterization is carried out by simultaneously imposing fermentation yield data in lactate, malate, acetate, and hydrogen production pathways for 19 measured metabolites spanning a library of 19 distinct single and multiple gene knockout mutants along with 18 intracellular metabolite concentration data for a Δgldh mutant and ten experimentally measured Michaelis–Menten kinetic parameters. Conclusions. The k-ctherm118 model captures significant metabolic changes caused by (1) nitrogen limitation leading to increased yields for lactate, pyruvate, and amino acids, and (2) ethanol stress causing an increase in intracellular sugar phosphate concentrations (~1.5-fold) due to upregulation of cofactor pools. Robustness analysis of k-ctherm118 alludes to the presence of a secondary activity of ketol-acid reductoisomerase and possible regulation by valine and/or leucine pool levels. In addition, cross-validation and robustness analysis allude to missing elements in k-ctherm118 and suggest additional experiments to improve kinetic model prediction fidelity. Overall, the study quantitatively assesses the advantages of EM-based kinetic modeling towards improved prediction of C. thermocellum metabolism and develops a predictive kinetic model which can be used to design biofuel-overproducing strains.« less

Low Temperature Fluorination of Aerosol Suspensions of Hydrocarbons Utilizing Elemental Fluorine. Aerosol Direct Fluorination-Syntheses of Perfluoroketones.

DTIC Science & Technology

1983-03-01

81.16 ppm (in) 3 *CF 2 - -126.31 ppm (an) 2 *CF2 - -118.66 ppm (an) 2 (a) See Ref. 11. (b) A. L. Renne and Win. C. Francis, 3. Amr. Cbes. Sat...Knoxville’>Tennessee 37916 1 Professor R. Neilson Dr. A. Cowley Department of Chemistry Department of Chemistry Texas Christian University University

Study of rolling element dynamic interactions with separators and raceway paths: Roller to separator contact forces and cage to shaft speed ratios in roller bearings

NASA Technical Reports Server (NTRS)

Nypan, L. J.

1978-01-01

Cage to roller force measurements, cage to shaft forces, and cage to shaft speed ratios are reported for 115 and 118mm bore roller bearings operating at speeds of 4,000, 8,000, and 12,000 rpm under loads ranging from 360 to 6670 N (80 to 1500 lb).

Implementation of a diode-pumped Nd:YAG laser with quick-change output couplers for high-beam quality 1064 or 532 nm wavelength generation

NASA Astrophysics Data System (ADS)

Li, Chun-Hao; Tsai, Ming-Jong

2009-06-01

A novel diode-pumped Nd:YAG laser system that employs a fixed active laser medium and a pair of quick-change output couplers on a precision linear stage for 1064 or 532 nm wavelength generation is presented. Fixed elements include a rear mirror, an acousto-optical Q-switch, and a diode-pumped solid-state laser (DPSSL). Movable elements for 1064 nm generation include an intra-cavity aperture as a mode selection element (MSE) and an output coupler. Movable elements for 532 nm generation include an intra-cavity frequency conversion with KTP, an intra-cavity aperture as a mode selection element (MSE), and an output coupler. Under stable operating conditions, the 1064 nm configuration produced a beam propagation ratio of 1.18 whereas the 532 nm configuration produced a beam propagation ratio of 1.1, both of which used an intra-cavity MSE with an aperture of 1.2 mm and a length of 5 mm.

Chemistry of the superheavy elements.

PubMed

Schädel, Matthias

2015-03-13

The quest for superheavy elements (SHEs) is driven by the desire to find and explore one of the extreme limits of existence of matter. These elements exist solely due to their nuclear shell stabilization. All 15 presently 'known' SHEs (11 are officially 'discovered' and named) up to element 118 are short-lived and are man-made atom-at-a-time in heavy ion induced nuclear reactions. They are identical to the transactinide elements located in the seventh period of the periodic table beginning with rutherfordium (element 104), dubnium (element 105) and seaborgium (element 106) in groups 4, 5 and 6, respectively. Their chemical properties are often surprising and unexpected from simple extrapolations. After hassium (element 108), chemistry has now reached copernicium (element 112) and flerovium (element 114). For the later ones, the focus is on questions of their metallic or possibly noble gas-like character originating from interplay of most pronounced relativistic effects and electron-shell effects. SHEs provide unique opportunities to get insights into the influence of strong relativistic effects on the atomic electrons and to probe 'relativistically' influenced chemical properties and the architecture of the periodic table at its farthest reach. In addition, they establish a test bench to challenge the validity and predictive power of modern fully relativistic quantum chemical models. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl.

PubMed Central

Matsumoto, M; Imagawa, M; Aoki, Y

1999-01-01

3,3',4,4',5-Pentachlorobiphenyl (PenCB), one of the most toxic co-planar polychlorinated biphenyl congeners, specifically induces class Pi glutathione S-transferase (GSTP1) as well as cytochrome P-450 1A1 in primary cultured rat liver parenchymal cells [Aoki, Matsumoto and Suzuki (1993) FEBS Lett. 333, 114-118]. However, the 5'-flanking sequence of the GSTP1 gene does not contain a xenobiotic responsive element, to which arylhydrocarbon receptor binds. Using a chloramphenicol acetyltransferase assay we demonstrate here that the enhancer termed GSTP1 enhancer I (GPEI) is necessary for the stimulation by PenCB of GSTP1 gene expression in primary cultured rat liver parenchymal cells. GPEI is already known to contain a dyad of PMA responsive element-like elements oriented palindromically. It is suggested that a novel signal transduction pathway activated by PenCB contributes to the stimulation of GSTP1 expression. PMID:10051428

Final Hazard Categorization for the Remediation of the 118-D-1, 118-D-2, 118-D-3, 118-H-1, 118-H-2, and 118-H-3 Solid Waste Burial Grounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

T. J. Rodovsky

2006-12-06

This report presents the final hazard categorization (FHC) for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site.

Final Hazard Categorization for the Remediation of the 118-D-1, 118-D-2, 118-D-3, 118-H-1, 118-H-2, and 118-H-3 Solid Waste Burial Grounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

T. J. Rodovsky

2007-04-12

This report presents the final hazard categorization (FHC) for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site.

Final Hazard Categorization and Auditable Safety Analysis for the Remediation of the 118-D-1, 118-D-2, 118-D-3, 118-H-1, 118-H-2 and 118-H-3 Solid Waste Burial Grounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

T. J. Rodovsky

2006-03-01

This report presents the initial hazard categorization, final hazard categorization and auditable safety analysis for the remediation of the 118-D-1, 118-D-2, and 118-D-3 Burial Grounds located within the 100-D/DR Area of the Hanford Site and the 118-H-1, 118-H-2, and 118-H-3 Burial Grounds located within the 100-H Area of the Hanford Site.

All-fiber polarization locked vector soliton laser using carbon nanotubes.

PubMed

Mou, C; Sergeyev, S; Rozhin, A; Turistyn, S

2011-10-01

We report an all-fiber mode-locked erbium-doped fiber laser (EDFL) employing carbon nanotube (CNT) polymer composite film. By using only standard telecom grade components, without any complex polarization control elements in the laser cavity, we have demonstrated polarization locked vector solitons generation with duration of ~583 fs, average power of ~3 mW (pulse energy of 118 pJ) at the repetition rate of ~25.7 MHz. © 2011 Optical Society of America

Phytoextraction of risk elements by willow and poplar trees.

PubMed

Kacálková, Lada; Tlustoš, Pavel; Száková, Jiřina

2015-01-01

To characterize the phytoextraction efficiency of two clones of willow trees (Salix x smithiana Willd., Salix rubens) and two clones of poplar trees (Populus nigra x maximowiczii, Populus nigra Wolterson) were planted in contaminated soil (0.4-2.0 mg Cd.kg(-1), 78-313 mg Zn.kg(-1), 21.3-118 mg Cu.kg(-1)). Field experiment was carried out in Czech Republic. The study investigated their ability to accumulate heavy metals (Cd, Zn, and Cu) in harvestable plant parts. The poplars produced higher amount of biomass than willows. Both Salix clones accumulated higher amount of Cd, Zn and Cu in their biomass (maximum 6.8 mg Cd.kg(-1), 909 mg Zn.kg(-1), and 17.7 mg Cu.kg(-1)) compared to Populus clones (maximum 2.06 mg Cd.kg(-1), 463 mg Zn.kg(-1), and 11.8 mg Cu.kg(-1)). There were no significant differences between clones of individual species. BCs for Cd and Zn were greater than 1 (the highest in willow leaves). BCs values of Cu were very low. These results indicate that Salix is more suitable plant for phytoextraction of Cd and Zn than Populus. The Cu phytoextraction potential of Salix and Populus trees was not confirmed in this experiment due to low soil availability of this element.

New Fragment Separation Technology for Superheavy Element Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shaughnessy, D A; Moody, K J; Henderson, R A

2008-01-28

This project consisted of three major research areas: (1) development of a solid Pu ceramic target for the MASHA separator, (2) chemical separation of nuclear decay products, and (3) production of new isotopes and elements through nuclear reactions. There have been 16 publications as a result of this project, and this collection of papers summarizes our accomplishments in each of the three areas of research listed above. The MASHA (Mass Analyzer for Super-Heavy Atoms) separator is being constructed at the U400 Cyclotron at the Flerov Laboratory of Nuclear Reactions in Dubna, Russia. The purpose of the separator is to physicallymore » separate the products from nuclear reactions based on their isotopic masses rather than their decay characteristics. The separator was designed to have a separation between isotopic masses of {+-}0.25 amu, which would enable the mass of element 114 isotopes to be measured with outstanding resolution, thereby confirming their discovery. In order to increase the production rate of element 114 nuclides produced via the {sup 244}Pu+{sup 48}Ca reaction, a new target technology was required. Instead of a traditional thin actinide target, the MASHA separator required a thick, ceramic-based Pu target that was thick enough to increase element 114 production while still being porous enough to allow reaction products to migrate out of the target and travel through the separator to the detector array located at the back end. In collaboration with UNLV, we began work on development of the Pu target for MASHA. Using waste-form synthesis technology, we began by creating zirconia-based matrices that would form a ceramic with plutonium oxide. We used samarium oxide as a surrogate for Pu and created ceramics that had varying amounts of the starting materials in order to establish trends in material density and porosity. The results from this work are described in more detail in Refs. [1,4,10]. Unfortunately, work on MASHA was delayed in Russia because it was found that the efficiency of transporting products from the target chamber to the detector array was much too low for applications in heavy element experiments where production rates are on the order of one atom per day or less. Work continues on the MASHA separator, and once the efficiency has been improved, we plan to continue our work on the Pu target for future element 114 experiments. Due to the delays of the MASHA separator, work on establishing the identity of heavy element species produced through nuclear reactions focused instead on chemical separations. In particular, element 115 decays through a series of alpha decays, terminating with an element 105 isotope with a long half-life ({approx} 1 day). By chemically separating the element 105 daughter and observing its subsequent fission decay, the identity of the original parent nucleus can be established through the genetic correlation of the initial series of alpha decays. Chemical separations of element 105 were developed in Switzerland, Russia, and at LLNL. Over the course of two experiments, reaction products from the {sup 243}Am+{sup 48}Ca reaction were collected in a copper block and subsequently processed for chemical separation of the Group Five elements [8,9,13,15]. The Group Five elements were initially separated from the Group Four species, and then the samples were sub-divided into tantalum and niobium fractions. All of the fission events were observed in the tantalum fractions, which implied that element 105 behaved more like tantalum under the chemical conditions of these experiments. These experiments were very successful, and not only demonstrated that chemical separation could be performed on single atoms of interest, but also lent proof to the identity of the parent nucleus as element 115. Subsequent analysis of the alpha spectra taken during the experiment further prove that the fission events observed during the two experiments came from element 105 as the decay daughter of element 115 and could not attributed to interference from other background species [16]. The final aspect of this project was the production of new isotopes and elements. All of the experiments were performed in Dubna at the U400 Cyclotron and the results are described in more detail in Refs. [2,3,5-8,11,12,14]. The first experiments were designed to establish the decay properties of isotopes of elements 112, 114, and 116 [5]. Because these isotopic signatures were established through these initial experiments, the discovery of element 118 [11] was possible, since the 118 nuclides decayed into these previously studied isotopes. This was the first successful report of the discovery of element 118, which was reported by the media to a large extent. The last experiment that was performed for this project was the production and detection of a new isotope of element 113 [14].« less

Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry.

PubMed

Poon, G K; Raynaud, F I; Mistry, P; Odell, D E; Kelland, L R; Harrap, K R; Barnard, C F; Murrer, B A

1995-09-29

Bis(acetato)amminedichloro(cyclohexylamine) platinum(IV) (JM216) is a new orally administered platinum complex with antitumor properties, and is currently undergoing phase II clinical trials. When JM216 was incubated with human plasma ultrafiltrate, 93% of the platinum species were protein-bound and 7% were unbound. The unbound platinum complexes in the ultrafiltrates of human plasma were analysed using a liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method. Apart from the parent drug, four metabolites were identified and characterised. These include JM118 [amminedichloro(cyclohexylamine) platinum(II)], JM383 [bis(acetato)ammine(cyclohexylamine)dihydroxo platinum(IV)] and the two isomers JM559 and JM518 [bis(acetato)amminechloro(cyclohexylamine) hydroxo platinum(IV)]. Their elemental compositions were determined by accurate mass measurement during the LC analysis, to confirm their identities. Quantitation of these metabolites by off-line LC atomic absorption spectroscopy demonstrated that JM118 is the major metabolite in plasma from patients receiving JM216 treatment.

Modern physics - Guest editorial

NASA Astrophysics Data System (ADS)

Howes, Ruth

2000-02-01

What an exciting time to be a physicist! You only have to attend the plenaries at an AAPT meeting to realize just how many mysteries there still are. Will string theory actually prove to be a Theory of Everything? Can we use physics to understand, predict, and perhaps eventually mitigate damaging hurricanes? Is the warming trend of the Earth due to man-made changes in the atmosphere? Have we found the nuclear "island of stability" with elements 114, 116, and 118? For that matter, why is ice slippery?

Comparisons and Evaluation of Hall Thruster Models

DTIC Science & Technology

2002-03-20

COVERED (FROM - TO) 20-04-2001 to 20-04-2002 4. TITLE AND SUBTITLE comparisons and Evaluation of Hall Thruster Models Unclassified 5a. CONTRACT NUMBER...TITLE AND SUBTITLE Comparisons and Evaluation of Hall Thruster Models 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 5d. TASK NUMBER 6. AUTHOR(S...evaluation of Hall thruster models G. J. M. Hagelaar, J. Bareilles, L. Garrigues, and J.-P. Boeuf CPAT, Bâtiment 3R2, Université Paul Sabatier 118 Route

Creation of Novel Solid-Solution Alloy Nanoparticles on the Basis of Density-of-States Engineering by Interelement Fusion.

PubMed

Kobayashi, Hirokazu; Kusada, Kohei; Kitagawa, Hiroshi

2015-06-16

Currently 118 known elements are represented in the periodic table. Of these 118 elements, only about 80 elements are stable, nonradioactive, and widely available for our society. From the viewpoint of the "elements strategy", we need to make full use of the 80 elements to bring out their latent ability and create innovative materials. Furthermore, there is a strong demand that the use of rare or toxic elements be reduced or replaced while their important properties are retained. Advanced science and technology could create higher-performance materials even while replacing or reducing minor or harmful elements through the combination of more abundant elements. The properties of elements are correlated directly with their electronic states. In a solid, the magnitude of the density of states (DOS) at the Fermi level affects the physical and chemical properties. In the present age, more attention has been paid to improving the properties of materials by means of alloying elements. In particular, the solid-solution-type alloy is advantageous because the properties can be continuously controlled by tuning the compositions and/or combinations of the constituent elements. However, the majority of bulk alloys are of the phase-separated type under ambient conditions, where constituent elements are immiscible with each other. To overcome the challenge of the bulk-phase metallurgical aspects, we have focused on the nanosize effect and developed methods involving "nonequilibrium synthesis" or "a process of hydrogen absorption/desorption". We propose a new concept of "density-of-states engineering" for the design of materials having the most desirable and suitable properties by means of "interelement fusion". In this Account, we describe novel solid-solution alloys of Pd-Pt, Ag-Rh, and Pd-Ru systems in which the constituent elements are immiscible in the bulk state. The homogeneous solid-solution alloys of Pd and Pt were created from Pd core/Pt shell nanoparticles using a hydrogen absorption/desorption process as a trigger. Several atom percent replacements of Pd with Pt atoms resulted in a significantly enhanced hydrogen absorption capacity compared with Pd nanoparticles. AgxRh1-x and PdxRu1-x solid-solution alloy nanoparticles were also developed by nonequilibrium synthesis based on a polyol method. The AgxRh1-x nanoparticles demonstrated hydrogen storage properties, although pure metal nanoparticles of each constituent element do not adsorb hydrogen. AgxRh1-x is therefore considered to possess a similar electronic structure to Pd as a synthetic pseudo-palladium. The PdxRu1-x nanoparticles showed enhanced catalytic activity for CO oxidation, with the highest catalytic activity found using the equimolar Pd0.5Ru0.5 nanoparticles. The catalytic activity of the Pd0.5Ru0.5 nanoparticles exceeds that of the widely used and best-performing Ru catalysts for CO oxidation and is also higher than that of neighboring Rh on the periodic table. Our present work provides a guiding principle for the design of a suitable DOS shape according to the intended physical and/or chemical properties and a method for the development of novel solid-solution alloys.

Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp. salivarius UCC118.

PubMed

Flynn, Sarah; van Sinderen, Douwe; Thornton, Gerardine M; Holo, Helge; Nes, Ingolf F; Collins, J Kevin

2002-04-01

ABP-118, a small heat-stable bacteriocin produced by Lactobacillus salivarius subsp. salivarius UCC118, a strain isolated from the ileal-caecal region of the human gastrointestinal tract, was purified to homogeneity. Using reverse genetics, a DNA fragment specifying part of ABP-118 was identified on a 10769 bp chromosomal region. Analysis of this region revealed that ABP-118 was a Class IIb two-peptide bacteriocin composed of Abp118alpha, which exhibited the antimicrobial activity, and Abp118beta, which enhanced the antimicrobial activity. The gene conferring strain UCC118 immunity to the action of ABP-118, abpIM, was identified downstream of the abp118beta gene. Located further downstream of abp118beta, several ORFs were identified whose deduced proteins resembled those of proteins involved in bacteriocin regulation and secretion. Heterologous expression of ABP-118 was achieved in Lactobacillus plantarum, Lactococcus lactis and Bacillus cereus. In addition, the abp118 locus encoded an inducing peptide, AbpIP, which was shown to play a role in the regulation of ABP-118 production. This novel bacteriocin is, to the authors' knowledge, the first to be isolated from a known human probiotic bacterium and to be characterized at the genetic level.

Nuclear field shift in natural environments

NASA Astrophysics Data System (ADS)

Moynier, Frédéric; Fujii, Toshiyuki; Brennecka, Gregory A.; Nielsen, Sune G.

2013-03-01

The nuclear field shift (NFS) is an isotope shift in atomic energy levels caused by a combination of differences in nuclear size and shape and electron densities at the nucleus. The effect of NFS in isotope fractionation was theoretically established by Bigeleisen in 1996 [Bigeleisen J. (1996) J. Am. Chem. Soc. 118:3676-3680] and has been analytically measured in laboratory chemical exchange reactions. More recently, some isotopic variations of heavy elements (Hg, Tl, U) measured in natural systems as well as isotopic anomalies measured for lower-mass elements in meteorites have been attributed to the NFS effect. These isotopic variations open up new and exciting fields of investigations in Earth sciences. In this paper, we review the different natural systems in which NFS has been proposed to be the origin of isotopic variations.

Synthesis of superheavy elements at the Dubna gas-filled recoil separator

NASA Astrophysics Data System (ADS)

Voinov, A. A.

2016-12-01

A survey of experiments at the Dubna gas-filled recoil separator (Laboratory of Nuclear Reactions, JINR, Dubna) aimed at the detection and study of the "island of stability" of superheavy nuclei produced in complete fusion reactions of 48Ca ions and 238U-249Cf target nuclei is given. The problems of synthesis of superheavy nuclei, methods for their identification, and investigation of their decay properties, including the results of recent experiments at other separators (SHIP, BGS, TASCA) and chemical setups, are discussed. The studied properties of the new nuclei, the isotopes of elements 112-118, as well as the properties of their decay products, indicate substantial growth of stability of the heaviest nuclei with increasing number of neutrons in the nucleus as the magic number of neutrons N = 184 is approached.

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

PubMed

Dunning, Alison M; Michailidou, Kyriaki; Kuchenbaecker, Karoline B; Thompson, Deborah; French, Juliet D; Beesley, Jonathan; Healey, Catherine S; Kar, Siddhartha; Pooley, Karen A; Lopez-Knowles, Elena; Dicks, Ed; Barrowdale, Daniel; Sinnott-Armstrong, Nicholas A; Sallari, Richard C; Hillman, Kristine M; Kaufmann, Susanne; Sivakumaran, Haran; Moradi Marjaneh, Mahdi; Lee, Jason S; Hills, Margaret; Jarosz, Monika; Drury, Suzie; Canisius, Sander; Bolla, Manjeet K; Dennis, Joe; Wang, Qin; Hopper, John L; Southey, Melissa C; Broeks, Annegien; Schmidt, Marjanka K; Lophatananon, Artitaya; Muir, Kenneth; Beckmann, Matthias W; Fasching, Peter A; Dos-Santos-Silva, Isabel; Peto, Julian; Sawyer, Elinor J; Tomlinson, Ian; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E; Flyger, Henrik; González-Neira, Anna; Perez, Jose I A; Anton-Culver, Hoda; Eunjung, Lee; Arndt, Volker; Brenner, Hermann; Meindl, Alfons; Schmutzler, Rita K; Brauch, Hiltrud; Hamann, Ute; Aittomäki, Kristiina; Blomqvist, Carl; Ito, Hidemi; Matsuo, Keitaro; Bogdanova, Natasha; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Kosma, Veli-Matti; Mannermaa, Arto; Tseng, Chiu-Chen; Wu, Anna H; Lambrechts, Diether; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Peterlongo, Paolo; Radice, Paolo; Olson, Janet E; Giles, Graham G; Milne, Roger L; Haiman, Christopher A; Henderson, Brian E; Goldberg, Mark S; Teo, Soo H; Yip, Cheng Har; Nord, Silje; Borresen-Dale, Anne-Lise; Kristensen, Vessela; Long, Jirong; Zheng, Wei; Pylkäs, Katri; Winqvist, Robert; Andrulis, Irene L; Knight, Julia A; Devilee, Peter; Seynaeve, Caroline; Figueroa, Jonine; Sherman, Mark E; Czene, Kamila; Darabi, Hatef; Hollestelle, Antoinette; van den Ouweland, Ans M W; Humphreys, Keith; Gao, Yu-Tang; Shu, Xiao-Ou; Cox, Angela; Cross, Simon S; Blot, William; Cai, Qiuyin; Ghoussaini, Maya; Perkins, Barbara J; Shah, Mitul; Choi, Ji-Yeob; Kang, Daehee; Lee, Soo Chin; Hartman, Mikael; Kabisch, Maria; Torres, Diana; Jakubowska, Anna; Lubinski, Jan; Brennan, Paul; Sangrajrang, Suleeporn; Ambrosone, Christine B; Toland, Amanda E; Shen, Chen-Yang; Wu, Pei-Ei; Orr, Nick; Swerdlow, Anthony; McGuffog, Lesley; Healey, Sue; Lee, Andrew; Kapuscinski, Miroslav; John, Esther M; Terry, Mary Beth; Daly, Mary B; Goldgar, David E; Buys, Saundra S; Janavicius, Ramunas; Tihomirova, Laima; Tung, Nadine; Dorfling, Cecilia M; van Rensburg, Elizabeth J; Neuhausen, Susan L; Ejlertsen, Bent; Hansen, Thomas V O; Osorio, Ana; Benitez, Javier; Rando, Rachel; Weitzel, Jeffrey N; Bonanni, Bernardo; Peissel, Bernard; Manoukian, Siranoush; Papi, Laura; Ottini, Laura; Konstantopoulou, Irene; Apostolou, Paraskevi; Garber, Judy; Rashid, Muhammad Usman; Frost, Debra; Izatt, Louise; Ellis, Steve; Godwin, Andrew K; Arnold, Norbert; Niederacher, Dieter; Rhiem, Kerstin; Bogdanova-Markov, Nadja; Sagne, Charlotte; Stoppa-Lyonnet, Dominique; Damiola, Francesca; Sinilnikova, Olga M; Mazoyer, Sylvie; Isaacs, Claudine; Claes, Kathleen B M; De Leeneer, Kim; de la Hoya, Miguel; Caldes, Trinidad; Nevanlinna, Heli; Khan, Sofia; Mensenkamp, Arjen R; Hooning, Maartje J; Rookus, Matti A; Kwong, Ava; Olah, Edith; Diez, Orland; Brunet, Joan; Pujana, Miquel Angel; Gronwald, Jacek; Huzarski, Tomasz; Barkardottir, Rosa B; Laframboise, Rachel; Soucy, Penny; Montagna, Marco; Agata, Simona; Teixeira, Manuel R; Park, Sue Kyung; Lindor, Noralane; Couch, Fergus J; Tischkowitz, Marc; Foretova, Lenka; Vijai, Joseph; Offit, Kenneth; Singer, Christian F; Rappaport, Christine; Phelan, Catherine M; Greene, Mark H; Mai, Phuong L; Rennert, Gad; Imyanitov, Evgeny N; Hulick, Peter J; Phillips, Kelly-Anne; Piedmonte, Marion; Mulligan, Anna Marie; Glendon, Gord; Bojesen, Anders; Thomassen, Mads; Caligo, Maria A; Yoon, Sook-Yee; Friedman, Eitan; Laitman, Yael; Borg, Ake; von Wachenfeldt, Anna; Ehrencrona, Hans; Rantala, Johanna; Olopade, Olufunmilayo I; Ganz, Patricia A; Nussbaum, Robert L; Gayther, Simon A; Nathanson, Katherine L; Domchek, Susan M; Arun, Banu K; Mitchell, Gillian; Karlan, Beth Y; Lester, Jenny; Maskarinec, Gertraud; Woolcott, Christy; Scott, Christopher; Stone, Jennifer; Apicella, Carmel; Tamimi, Rulla; Luben, Robert; Khaw, Kay-Tee; Helland, Åslaug; Haakensen, Vilde; Dowsett, Mitch; Pharoah, Paul D P; Simard, Jacques; Hall, Per; García-Closas, Montserrat; Vachon, Celine; Chenevix-Trench, Georgia; Antoniou, Antonis C; Easton, Douglas F; Edwards, Stacey L

2016-04-01

We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. The best candidate causal variants for ER(-) tumors lie in four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaining independent causal variant disrupt a silencer element and putatively increase ESR1 and RMND1 expression.

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

PubMed Central

Dunning, Alison M; Michailidou, Kyriaki; Kuchenbaecker, Karoline B; Thompson, Deborah; French, Juliet D; Beesley, Jonathan; Healey, Catherine S; Kar, Siddhartha; Pooley, Karen A; Lopez-Knowles, Elena; Dicks, Ed; Barrowdale, Daniel; Sinnott-Armstrong, Nicholas A; Sallari, Richard C; Hillman, Kristine M; Kaufmann, Susanne; Sivakumaran, Haran; Marjaneh, Mahdi Moradi; Lee, Jason S; Hills, Margaret; Jarosz, Monika; Drury, Suzie; Canisius, Sander; Bolla, Manjeet K; Dennis, Joe; Wang, Qin; Hopper, John L; Southey, Melissa C; Broeks, Annegien; Schmidt, Marjanka K; Lophatananon, Artitaya; Muir, Kenneth; Beckmann, Matthias W; Fasching, Peter A; dos-Santos-Silva, Isabel; Peto, Julian; Sawyer, Elinor J; Tomlinson, Ian; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E; Flyger, Henrik; González-Neira, Anna; Perez, Jose I A; Anton-Culver, Hoda; Eunjung, Lee; Arndt, Volker; Brenner, Hermann; Meindl, Alfons; Schmutzler, Rita K; Brauch, Hiltrud; Hamann, Ute; Aittomäki, Kristiina; Blomqvist, Carl; Ito, Hidemi; Matsuo, Keitaro; Bogdanova, Natasha; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Kosma, Veli-Matti; Mannermaa, Arto; Tseng, Chiu-chen; Wu, Anna H; Lambrechts, Diether; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Peterlongo, Paolo; Radice, Paolo; Olson, Janet E; Giles, Graham G; Milne, Roger L; Haiman, Christopher A; Henderson, Brian E; Goldberg, Mark S; Teo, Soo H; Yip, Cheng Har; Nord, Silje; Borresen-Dale, Anne-Lise; Kristensen, Vessela; Long, Jirong; Zheng, Wei; Pylkäs, Katri; Winqvist, Robert; Andrulis, Irene L; Knight, Julia A; Devilee, Peter; Seynaeve, Caroline; Figueroa, Jonine; Sherman, Mark E; Czene, Kamila; Darabi, Hatef; Hollestelle, Antoinette; van den Ouweland, Ans M W; Humphreys, Keith; Gao, Yu-Tang; Shu, Xiao-Ou; Cox, Angela; Cross, Simon S; Blot, William; Cai, Qiuyin; Ghoussaini, Maya; Perkins, Barbara J; Shah, Mitul; Choi, Ji-Yeob; Kang, Daehee; Lee, Soo Chin; Hartman, Mikael; Kabisch, Maria; Torres, Diana; Jakubowska, Anna; Lubinski, Jan; Brennan, Paul; Sangrajrang, Suleeporn; Ambrosone, Christine B; Toland, Amanda E; Shen, Chen-Yang; Wu, Pei-Ei; Orr, Nick; Swerdlow, Anthony; McGuffog, Lesley; Healey, Sue; Lee, Andrew; Kapuscinski, Miroslav; John, Esther M; Terry, Mary Beth; Daly, Mary B; Goldgar, David E; Buys, Saundra S; Janavicius, Ramunas; Tihomirova, Laima; Tung, Nadine; Dorfling, Cecilia M; van Rensburg, Elizabeth J; Neuhausen, Susan L; Ejlertsen, Bent; Hansen, Thomas V O; Osorio, Ana; Benitez, Javier; Rando, Rachel; Weitzel, Jeffrey N; Bonanni, Bernardo; Peissel, Bernard; Manoukian, Siranoush; Papi, Laura; Ottini, Laura; Konstantopoulou, Irene; Apostolou, Paraskevi; Garber, Judy; Rashid, Muhammad Usman; Frost, Debra; Izatt, Louise; Ellis, Steve; Godwin, Andrew K; Arnold, Norbert; Niederacher, Dieter; Rhiem, Kerstin; Bogdanova-Markov, Nadja; Sagne, Charlotte; Stoppa-Lyonnet, Dominique; Damiola, Francesca; Sinilnikova, Olga M; Mazoyer, Sylvie; Isaacs, Claudine; Claes, Kathleen B M; De Leeneer, Kim; de la Hoya, Miguel; Caldes, Trinidad; Nevanlinna, Heli; Khan, Sofia; Mensenkamp, Arjen R; Hooning, Maartje J; Rookus, Matti A; Kwong, Ava; Olah, Edith; Diez, Orland; Brunet, Joan; Pujana, Miquel Angel; Gronwald, Jacek; Huzarski, Tomasz; Barkardottir, Rosa B; Laframboise, Rachel; Soucy, Penny; Montagna, Marco; Agata, Simona; Teixeira, Manuel R; Park, Sue Kyung; Lindor, Noralane; Couch, Fergus J; Tischkowitz, Marc; Foretova, Lenka; Vijai, Joseph; Offit, Kenneth; Singer, Christian F; Rappaport, Christine; Phelan, Catherine M; Greene, Mark H; Mai, Phuong L; Rennert, Gad; Imyanitov, Evgeny N; Hulick, Peter J; Phillips, Kelly-Anne; Piedmonte, Marion; Mulligan, Anna Marie; Glendon, Gord; Bojesen, Anders; Thomassen, Mads; Caligo, Maria A; Yoon, Sook-Yee; Friedman, Eitan; Laitman, Yael; Borg, Ake; von Wachenfeldt, Anna; Ehrencrona, Hans; Rantala, Johanna; Olopade, Olufunmilayo I; Ganz, Patricia A; Nussbaum, Robert L; Gayther, Simon A; Nathanson, Katherine L; Domchek, Susan M; Arun, Banu K; Mitchell, Gillian; Karlan, Beth Y; Lester, Jenny; Maskarinec, Gertraud; Woolcott, Christy; Scott, Christopher; Stone, Jennifer; Apicella, Carmel; Tamimi, Rulla; Luben, Robert; Khaw, Kay-Tee; Helland, Åslaug; Haakensen, Vilde; Dowsett, Mitch; Pharoah, Paul D P; Simard, Jacques; Hall, Per; García-Closas, Montserrat; Vachon, Celine; Chenevix-Trench, Georgia; Antoniou, Antonis C; Easton, Douglas F; Edwards, Stacey L

2016-01-01

We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER+ or ER−) and human ERBB2 (HER2+ or HER2−) tumor subtypes, mammographic density and tumor grade. The best candidate causal variants for ER− tumors lie in four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaining independent causal variant disrupt a silencer element and putatively increase ESR1 and RMND1 expression. PMID:26928228

Basic distinctions between cold- and hot-fusion reactions in the synthesis of superheavy elements

NASA Astrophysics Data System (ADS)

Nasirov, A. K.; Muminov, A. I.; Giardina, G.; Mandaglio, G.

2014-07-01

Superheavy elements (SHE) of charge number in the range of Z = 106-112 were synthesized in so-called cold-fusion reactions. The smallness of the excitation energy of compound nuclei is the main advantage of cold-fusion reactions. However, the synthesis of SHEs of charge number in the region of Z ≥ 112 is strongly complicated in cold-fusion reactions by a sharp decrease in the cross section of a compound nucleus formation in the entrance channel because of superiority of quasifission in the competition with complete fusion. Two favorable circumstances contributed to the success of the experiments aimed at the synthesis of the Z = 113-118 elements and performed at the Laboratory of Nuclear Reactions at the Joint Institute for Nuclear Research: large cross sections for the production of a compound nucleus, which are characteristic of hot-fusion reactions, and an increase in the fission barrier for nuclei toward the stability island. The factor that complicates the formation of a compound nucleus in cold-fusion reactions is discussed.

Body burden of toxic metals and rare earth elements in non-smokers, cigarette smokers and electronic cigarette users.

PubMed

Badea, Mihaela; Luzardo, Octavio P; González-Antuña, Ana; Zumbado, Manuel; Rogozea, Liliana; Floroian, Laura; Alexandrescu, Dana; Moga, Marius; Gaman, Laura; Radoi, Mariana; Boada, Luis D; Henríquez-Hernández, Luis Alberto

2018-06-13

Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements. Concentration of 42 elements, including trace elements, elements in the ATSDR's priority pollutant list and rare earth elements (REE) were measured by ICP-MS in the blood serum of participants. Cigarette smokers showed the highest levels of copper, molybdenum, zinc, antimony, and strontium. Electronic cigarette (e-cigarette) users presented the highest concentrations of selenium, silver, and vanadium. Beryllium, europium and lanthanides were detected more frequently among e-cigarette users (20.6%, 23.5%, and 14.7%) than in cigarette smokers (1.7%, 19.0%, and 12.1%, respectively); and the number of detected REE was also higher among e-cigarette users (11.8% of them showed more than 10 different elements). Serum levels of cerium and erbium increased as the duration of the use of e-cigarettes was longer. We have found that smoking is mainly a source of heavy metals while the use of e-cigarettes is a potential source of REE. However, these elements were detected at low concentrations. Copyright © 2018 Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soti, Zsolt; Magill, Joseph; Pfennig, Gerda

Following the success of the 8. Edition of the Karlsruhe Nuclide Chart 2012, a new edition is planned for 2015. Since the 2012 edition, more than 100 nuclides have been discovered and about 1400 nuclides have been updated. In summary, the new 9. edition contains decay and radiation data on approximately 3230 ground state nuclides and 740 isomers from 118 chemical elements. The accompanying booklet provides a detailed explanation of the nuclide box structure used in the Chart. An expanded section contains many additional nuclide decay schemes to aid the user to interpret the highly condensed information in the nuclidemore » boxes. The booklet contains - in addition to the latest values of the physical constants and physical properties - a periodic table of the elements, tables of new and updated nuclides, and a difference chart showing the main changes in the Chart graphically. (authors)« less

Results from the First {sup 249}Cf + {sup 48}Ca Experiment

DOE R&D Accomplishments Database

Oganessian, Y. T.; Utyonkov, V. K.; Lobanov, Y. V.; Abdullin, F. S.; Polyakov, A. N.; Shirokovsky, I. V.; Tsyganov, Y. S.; Mezentsev, A. N.; Iliev, S.; Subbotin, V. G.; Sukhov, A. M.; Ivanov, O. V.; Voinov, A. A.; Subotic, K.; Zagrebaev, V. I.; Itkis, M. G.; Moody, K. J.; Wild, J. F.; Stoyer, M. A.; Stoyer, N. J.; Laue, C. A.; Shaughnessy, D. A.; Patin, J. B.; Lougheed, R. W.

2003-02-03

The present paper reports the results of an attempt aimed at the synthesis of element 118 in the reaction {sup 249}Cf({sup 48}Ca,3n){sup 294}118. The experiment was performed employing the Dubna Gas-filled Recoil Separator and the U400 heavy-ion cyclotron at FLNR, JINR, Dubna. In the course of a 2300-hour irradiation of an enriched {sup 249}Cf target (0.23 mg/cm{sup 2}) with a beam of 245-MeV {sup 48}Ca ions, we accumulated a total beam dose of 2.5 x 10{sup 19} ions. We detected two events that may be attributed to the formation and decay of nuclei with Z=118. For one event, we observed a decay chain of two correlated {alpha}-decays with corresponding energies and correlation times of E{sub {alpha}1} = 11.65 {+-} 0.06 MeV, t{sub {alpha}1} = 2.55 ms and E{sub {alpha}2} = 10.71 {+-} 0.17 MeV, t{sub {alpha}2} = 42.1 ms and, finally, a spontaneous fission with the sum of the kinetic energies of the fission fragments E{sub tot} = 207 MeV (TKE {approx} 230 MeV) and t{sub SF} = 0.52 s. In the second event chain, the recoil nucleus decayed into two fission fragments with E{sub tot} = 223 MeV (TKE {approx} 245 MeV) 3.16 ms later, without intervening {alpha} decays. The probabilities that these events were caused by the chance correlations of unrelated signals are negligible. Both events were observed at an excitation energy of the compound nucleus {sup 297}118 of E* = 30.0 {+-} 2.4 MeV, close to the expected maximum of the 3n-evaporation channel. The relationship between the decay energy Q{sub {alpha}} and decay period T{sub {alpha}} shows that sequential {alpha}-transitions in the first event correspond to the decay chain with Z = 118{_}116{_}114. Decay characteristics of the newly observed nuclides are compared with radioactive decay properties of the even-even isotopes with Z = 116, 114 and 112 previously produced in the reactions {sup 244}Pu, {sup 248}Cm + {sup 48}Ca and calculations made in various nuclear models.

41 CFR 102-118.425 - Is my agency allowed to perform a postpayment audit on our transportation bills?

Code of Federal Regulations, 2010 CFR

2010-07-01

... perform a postpayment audit on our transportation bills? 102-118.425 Section 102-118.425 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits § 102-118...

41 CFR 102-118.435 - What procedures does GSA use to perform a postpayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... use to perform a postpayment audit? 102-118.435 Section 102-118.435 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits § 102-118.435 What...

The reactive element effect of yttrium and yttrium silicon on high temperature oxidation of NiCrAl coating

NASA Astrophysics Data System (ADS)

Ramandhany, S.; Sugiarti, E.; Desiati, R. D.; Martides, E.; Junianto, E.; Prawara, B.; Sukarto, A.; Tjahjono, A.

2018-03-01

The microstructure formed on the bond coat affects the oxidation resistance, particularly the formation of a protective oxide layer. The adhesion of bond coat and TGO increased significantly by addition of reactive element. In the present work, the effect of yttrium and yttrium silicon as reactive element (RE) on NiCrAl coating was investigated. The NiCrAl (without RE) and NiCrAlX (X:Y or YSi) bond coating were deposited on Hastelloy C-276 substrate by High Velocity Oxygen Fuel (HVOF) method. Isothermal oxidation was carried out at 1000 °C for 100 hours. The results showed that the addition of RE could prevent the breakaway oxidation. Therefore, the coating with reactive element were more protective against high temperature oxidation. Furthermore, the oxidation rate of NiCrAlY coating was lower than NiCrAlYSi coating with the total mass change was ±2.394 mg/cm2 after 100 hours of oxidation. The thickness of oxide scale was approximately 1.18 μm consisting of duplex oxide scale of spinel NiCr2O4 in outer scale and protective α-Al2O3 in inner scale.

41 CFR 102-118.445 - Must my agency pay for a postpayment audit when using the GSA Audit Division?

Code of Federal Regulations, 2010 CFR

2010-07-01

... postpayment audit when using the GSA Audit Division? 102-118.445 Section 102-118.445 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits § 102-118...

Computer-Aided Structural Engineering (CASE) Project. Finite Element Studies of a Horizontally Framed Miter Gate. Report 7. Application and Summary.

DTIC Science & Technology

1987-08-01

gate torsion is included in Part IV. The complete list of reports involved in the miter gate study can be found on page I of the preface. 17 . Before...Fig- ure 10. SM and CM results do not match. However, the pattern of distribution is similar; lower girders 17 and 18 carry high compression loads...118 (0.87) 142 (1.04) Girder 15 78 (0.57) 33 (0.24) Girder 16 -44 (-0.32) -30 (-0.22) Girder 17 -106 (-0.78) -147 (-1.08) Girder 18 -182 (-1.34) -134

21 CFR 118.6 - Egg testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Egg testing for Salmonella Enteritidis (SE). 118.6... (CONTINUED) FOOD FOR HUMAN CONSUMPTION PRODUCTION, STORAGE, AND TRANSPORTATION OF SHELL EGGS § 118.6 Egg... age required by § 118.4(a) is positive, you must divert eggs to treatment (defined in § 118.3) for the...

41 CFR 102-118.260 - Must my agency send all quotations, tenders, or contracts with a TSP to GSA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... quotations, tenders, or contracts with a TSP to GSA? 102-118.260 Section 102-118.260 Public Contracts and... REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Use of Government Billing Documents Quotations, Tenders Or Contracts § 102-118.260 Must my agency send all quotations, tenders, or contracts with a TSP to...

21 CFR 118.6 - Egg testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Egg testing for Salmonella Enteritidis (SE). 118.6... (CONTINUED) FOOD FOR HUMAN CONSUMPTION PRODUCTION, STORAGE, AND TRANSPORTATION OF SHELL EGGS § 118.6 Egg... age required by § 118.4(a) is positive, you must divert eggs to treatment (defined in § 118.3) for the...

Synthesis of superheavy elements at the Dubna gas-filled recoil separator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Voinov, A. A., E-mail: voinov@jinr.ru; Collaboration: JINR

2016-12-15

A survey of experiments at the Dubna gas-filled recoil separator (Laboratory of Nuclear Reactions, JINR, Dubna) aimed at the detection and study of the “island of stability” of superheavy nuclei produced in complete fusion reactions of {sup 48}Ca ions and {sup 238}U–{sup 249}Cf target nuclei is given. The problems of synthesis of superheavy nuclei, methods for their identification, and investigation of their decay properties, including the results of recent experiments at other separators (SHIP, BGS, TASCA) and chemical setups, are discussed. The studied properties of the new nuclei, the isotopes of elements 112–118, as well as the properties of theirmore » decay products, indicate substantial growth of stability of the heaviest nuclei with increasing number of neutrons in the nucleus as the magic number of neutrons N = 184 is approached.« less

MM Herculis - An eclipsing binary of the RS CVn

NASA Technical Reports Server (NTRS)

Sowell, J. R.; Hall, D. S.; Henry, G. W.; Burke, E. W., Jr.; Milone, E. F.

1983-01-01

V, B and U differential photoelectric photometry has been obtained for the RS Canum Venaticorum-class eclipsing binary star MM Her, with the light outside the eclipse being Fourier-analyzed to study wave migration and amplitude. These, together with the mean light level of the system, have been monitored from 1976 through 1980. Observations within the eclipse have revealed eclipses to be partial, rather than total as previously thought. The geometric elements of the presently rectified light curve are forced on the pre-1980 light curves and found to be compatible. With these elements, and previously obtained double line radial velocity curves, new absolute dimensions of 1.18 solar masses and 1.58 solar radii are calculated for the hotter star and 1.27 solar masses and 2.83 solar radii for the cooler star. The plotting of color indices on the color-color curve indicates G2V and K2IV spectral types.

48 CFR 18.118 - Trade agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Trade agreements. 18.118 Section 18.118 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities 18.118 Trade agreements...

41 CFR 102-118.265 - What is a prepayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... audit? 102-118.265 Section 102-118.265 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements for Prepayment Audits...

7 CFR 1260.118 - Cattle.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Cattle. 1260.118 Section 1260.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Promotion and Research Order Definitions § 1260.118 Cattle. Cattle means live domesticated bovine animals...

Integrating 360° behavior-orientated feedback in communication skills training for medical undergraduates: concept, acceptance and students' self-ratings of communication competence.

PubMed

Engerer, Cosima; Berberat, Pascal O; Dinkel, Andreas; Rudolph, Baerbel; Sattel, Heribert; Wuensch, Alexander

2016-10-18

Feedback is considered a key didactic element in medical education, especially for teaching of communication skills. This study investigates the impact of a best evidence-based practice feedback concept within the context of communication skills training (CST). We evaluate this concept for acceptance and changes in students self-ratings of communication competence. Our CST integrating feedback process comprises a short theoretical introduction presenting standards for good communication and a constructive 360° feedback from three perspectives: feedback from peers, from standardized patients (SPs), and from a trainer. Feed-forward process was facilitated for documenting suggestions for improvements based on observable behaviors to maximize learning benefits. Our CST was applied to four groups of eight or nine students. We assessed the data on students' acceptance using a 6-point scale ranging from very good (1) to poor (6), applied a forced choice question to rank didactic items, and assessed changes in student' self-ratings of their communication competence on a 10-cm visual analogue scale (VAS). Thirty-four medical undergraduates (82 % female, 18 % male) in their first clinical year, with an average age of 21.4 years (SD = 1.0), participated in the new training. The concept achieved high acceptance from good to very good: overall impression (M = 1.56), sufficient interaction for discussion (M = 1.15), and constructive learning atmosphere (M = 1.18). Specific elements, such as practical training with SPs (M = 1.18) and feedback by SPs (M = 1.12), showed highest acceptance. The forced choice ranking placed all feedback elements at the top of the list (feedback (FB) by SPs, rank 2; FB by trainer, rank 3; FB by colleagues, rank 4), whereas theoretical elements were at the bottom (theoretical introduction, rank 7; memory card, rank 9). Overall, student self-ratings of communication competence significantly improved in nine of the ten communication items assessed by VAS and showed a pre-post effect size of ES = 0.74 on a global rating. This study demonstrates that the training concept based on 360° behavioral feedback was well accepted and generated significant changes in student self-ratings of their communication competence. Further research is needed to determine the effects on objective communication performance.

7 CFR 1956.118 - Approval authority.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Approval authority. 1956.118 Section 1956.118 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Community and Business Programs § 1956.118...

40 CFR 98.118 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Definitions. 98.118 Section 98.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Ferroalloy Production § 98.118 Definitions. All terms used of this subpart have the...

41 CFR 102-118.270 - Must my agency establish a prepayment audit program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... a prepayment audit program? 102-118.270 Section 102-118.270 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements...

41 CFR 102-118.410 - Can GSA suspend my agency's prepayment audit program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency's prepayment audit program? 102-118.410 Section 102-118.410 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Suspension of...

21 CFR 118.1 - Persons covered by the requirements in this part.

Code of Federal Regulations, 2011 CFR

2011-04-01

... a treatment as defined in § 118.3, you must comply only with the refrigeration requirements in § 118... with the refrigeration requirements in § 118.4(e). This section applies only to eggs from farms with 3...

21 CFR 118.1 - Persons covered by the requirements in this part.

Code of Federal Regulations, 2012 CFR

2012-04-01

... a treatment as defined in § 118.3, you must comply only with the refrigeration requirements in § 118... with the refrigeration requirements in § 118.4(e). This section applies only to eggs from farms with 3...

21 CFR 118.1 - Persons covered by the requirements in this part.

Code of Federal Regulations, 2013 CFR

2013-04-01

... a treatment as defined in § 118.3, you must comply only with the refrigeration requirements in § 118... with the refrigeration requirements in § 118.4(e). This section applies only to eggs from farms with 3...

21 CFR 118.1 - Persons covered by the requirements in this part.

Code of Federal Regulations, 2010 CFR

2010-04-01

... a treatment as defined in § 118.3, you must comply only with the refrigeration requirements in § 118... with the refrigeration requirements in § 118.4(e). This section applies only to eggs from farms with 3...

21 CFR 118.1 - Persons covered by the requirements in this part.

Code of Federal Regulations, 2014 CFR

2014-04-01

... a treatment as defined in § 118.3, you must comply only with the refrigeration requirements in § 118... with the refrigeration requirements in § 118.4(e). This section applies only to eggs from farms with 3...

40 CFR 51.118 - Stack height provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Stack height provisions. 51.118 Section 51.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Control Strategy § 51.118 Stack...

7 CFR 1150.118 - Marketing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 9 2013-01-01 2013-01-01 false Marketing. 1150.118 Section 1150.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Order Definitions § 1150.118 Marketing. Marketing means the sale or other disposition in commerce of...

7 CFR 1150.118 - Marketing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 9 2012-01-01 2012-01-01 false Marketing. 1150.118 Section 1150.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Definitions § 1150.118 Marketing. Marketing means the sale or other disposition in commerce of...

7 CFR 1150.118 - Marketing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 9 2014-01-01 2013-01-01 true Marketing. 1150.118 Section 1150.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Order Definitions § 1150.118 Marketing. Marketing means the sale or other disposition in commerce of...

7 CFR 1150.118 - Marketing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 9 2011-01-01 2011-01-01 false Marketing. 1150.118 Section 1150.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Definitions § 1150.118 Marketing. Marketing means the sale or other disposition in commerce of...

7 CFR 1150.118 - Marketing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Marketing. 1150.118 Section 1150.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Definitions § 1150.118 Marketing. Marketing means the sale or other disposition in commerce of...

Rheology of dense granular flows in two dimensions: Comparison of fully two-dimensional flows to unidirectional shear flow

NASA Astrophysics Data System (ADS)

Bhateja, Ashish; Khakhar, Devang V.

2018-06-01

We consider the rheology of steady two-dimensional granular flows, in different geometries, using discrete element method-based simulations of soft spheres. The flow classification parameter (ψ ), which defines the local flow type (ranging from pure rotation to simple shear to pure extension), varies spatially, to a significant extent, in the flows. We find that the material behaves as a generalized Newtonian fluid. The μ -I scaling proposed by Jop et al. [Nature (London) 441, 727 (2006), 10.1038/nature04801] is found to be valid in both two-dimensional and unidirectional flows, as observed in previous studies; however, the data for each flow geometry fall on a different curve. The results for the two-dimensional silo flow indicate that the viscosity does not depend directly on the flow type parameter, ψ . We find that the scaling based on "granular fluidity" [Zhang and Kamrin, Phys. Rev. Lett. 118, 058001 (2017), 10.1103/PhysRevLett.118.058001] gives good collapse of the data to a single curve for all the geometries. The data for the variation of the solid faction with inertial number show a reasonable collapse for the different geometries.

Expanded Owens Valley Solar Array (EOVSA) Testbed and Prototype

NASA Astrophysics Data System (ADS)

Gary, Dale E.; Nita, G. M.; Sane, N.

2012-05-01

NJIT is engaged in constructing a new solar-dedicated radio array, the Expanded Owens Valley Solar Array (EOVSA), which is slated for completion in late 2013. An initial 3-antenna array, the EOVSA Subsystem Testbed (EST), is now in operation from 1-9 GHz based on three of the old OVSA antennas, to test certain design elements of the new array. We describe this instrument and show some results from recent solar flares observed with it. We also describe plans for an upcoming prototype of EOVSA, which will use three antennas of the new design over the full 1-18 GHz signal chain of the entirely new system. The EOVSA prototype will be in operation by late 2012. Highlights of the new design are ability to cover the entire 1-18 GHz in less than 1 s, simultaneous dual polarization, and improved sensitivity and stability. We discuss what can be expected from the prototype, and how it will compare with the full 13-antenna EOVSA. This work was supported by NSF grants AGS-0961867 and AST-0908344, and NASA grant NNX11AB49G to New Jersey Institute of Technology.

Water quality of medium size watercourse under baseflow conditions: the case study of river Sutla in Croatia.

PubMed

Dragun, Zrinka; Kapetanović, Damir; Raspor, Biserka; Teskeredzić, Emin

2011-06-01

The study on medium size river Sutla in Croatia indicated considerable water contamination at specific sites during the baseflow period, probably associated to low flow-rate (0.73-68.8 m3 s(-1)), and consequently low dilution capacity of this river. Various aspects of contamination were observed: increased conductivity to 1,000 microS cm(-1), decreased dissolved oxygen level to 50%, 4-5 degrees C increased water temperature, increased concentrations of several dissolved trace elements (e.g., maximal values of Li: 45.4 microg l(-1); Rb: 10.4 microg l(-1); Mo: 20.1 microg l(-1); Cd: 0.31 microg l(-1); Sn: 30.2 microg l(-1); Sb: 11.8 microg l(-1); Pb: 1.18 microg l(-1); Ti: 1.03 microg l(-1); Mn: 261.1 microg l(-1); and Fe: 80.5 microg l(-1)) and macro elements (e.g., maximal values of Na: 107.5 mg l(-1); and K: 17.3 mg l(-1)), as well as moderate or even critical fecal (E. coli: 4,888 MPN/100 ml; total coliforms: 45,307 MPN/100 ml; enterococci: 1,303 MPN/100 ml) and organic pollution (heterotrophic bacteria: 94,000 cfu/ml). Although metal concentrations still have not exceeded the limits considered as hazardous for aquatic life or eventually for human health, the observed prominent increases of both metal concentrations and bacterial counts in the river water should be considered as a warning and incentive to protect the small and medium size rivers from the future deterioration, as recommended by EU Water Framework Directive.

Element-specific spectral imaging of multiple contrast agents: a phantom study

NASA Astrophysics Data System (ADS)

Panta, R. K.; Bell, S. T.; Healy, J. L.; Aamir, R.; Bateman, C. J.; Moghiseh, M.; Butler, A. P. H.; Anderson, N. G.

2018-02-01

This work demonstrates the feasibility of simultaneous discrimination of multiple contrast agents based on their element-specific and energy-dependent X-ray attenuation properties using a pre-clinical photon-counting spectral CT. We used a photon-counting based pre-clinical spectral CT scanner with four energy thresholds to measure the X-ray attenuation properties of various concentrations of iodine (9, 18 and 36 mg/ml), gadolinium (2, 4 and 8 mg/ml) and gold (2, 4 and 8 mg/ml) based contrast agents, calcium chloride (140 and 280 mg/ml) and water. We evaluated the spectral imaging performances of different energy threshold schemes between 25 to 82 keV at 118 kVp, based on K-factor and signal-to-noise ratio and ranked them. K-factor was defined as the X-ray attenuation in the K-edge containing energy range divided by the X-ray attenuation in the preceding energy range, expressed as a percentage. We evaluated the effectiveness of the optimised energy selection to discriminate all three contrast agents in a phantom of 33 mm diameter. A photon-counting spectral CT using four energy thresholds of 27, 33, 49 and 81 keV at 118 kVp simultaneously discriminated three contrast agents based on iodine, gadolinium and gold at various concentrations using their K-edge and energy-dependent X-ray attenuation features in a single scan. A ranking method to evaluate spectral imaging performance enabled energy thresholds to be optimised to discriminate iodine, gadolinium and gold contrast agents in a single spectral CT scan. Simultaneous discrimination of multiple contrast agents in a single scan is likely to open up new possibilities of improving the accuracy of disease diagnosis by simultaneously imaging multiple bio-markers each labelled with a nano-contrast agent.

41 CFR 102-118.10 - What is a transportation audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is a transportation audit? 102-118.10 Section 102-118.10 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

41 CFR 102-118.15 - What is a transportation payment?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is a transportation payment? 102-118.15 Section 102-118.15 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

41 CFR 102-118.280 - What advantages does the prepayment audit offer my agency?

Code of Federal Regulations, 2010 CFR

2010-07-01

... prepayment audit offer my agency? 102-118.280 Section 102-118.280 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements...

41 CFR 102-118.300 - How does my agency fund its prepayment audit program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... its prepayment audit program? 102-118.300 Section 102-118.300 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements...

Self-assembled nanostructures of optically active phthalocyanine derivatives. Effect of central metal ion on the morphology, dimension, and handedness.

PubMed

Sun, Ranran; Wang, Liang; Tian, Jing; Zhang, Xiaomei; Jiang, Jianzhuang

2012-11-21

Four optically active {(2,3,9,10,16,17,23,24-octa[(S)-2-methylbutoxy]} phthalocyanine derivatives with different central metal ions, namely (S)-H2Pc(β-OC5H11)8 (1), (S)-ZnPc(β-OC5H11)8 (2), (S)-CuPc(β-OC5H11)8 (3), and (S)-NiPc(β-OC5H11)8 (4) have been synthesized and their self-assembly behaviors systematically investigated by electronic absorption and circular dichroism (CD) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) techniques, and X-ray photoelectron spectroscopy (XPS). Metal free phthalocyanine together with its zinc and copper congeners self-assembles into right-handed helical arrangements in a stack of phthalocyanine chromophores according to the CD spectroscopic result, while the nickel complex does so into the left-handed helical arrangements. These helical arrangements, acting as elemental primary structures, further pack in a hierarchical fashion into either highly ordered right-handed fibrous nanostructures with average 300 μm length, 4.8 μm width, and 4.4 μm helical pitch for 1 and 300 μm length, 2.4 μm width, and 1.8 μm helical pitch for 2 but left-handed fibrous nanostructures with average 4 μm length, 0.48 μm width, and 0.12 μm helical pitch for 3 and 300 μm length, 2 μm width, and 1.2 μm helical pitch for 4, clearly revealing the effect of central metal ion on the distance and relative orientation of neighboring phthalocyanine chromophores and in turn the supramolecular chirality, morphology, dimension, and handedness of the self-assembled nanostructures. The present result not only represents a unique phenomenon in the self-assembly of phthalocyanine compounds but more importantly denotes the transcription and amplification of molecular chirality to supramolecular helicity with different helical bias during the self-assembly processes without changing the chiral handles attached to the phthalocyanine chromophore.

33 CFR 118.140 - Painting bridge piers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Painting bridge piers. 118.140 Section 118.140 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.140 Painting bridge piers. The District Commander may require...

33 CFR 118.90 - Bridges crossing channel obliquely.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bridges crossing channel obliquely. 118.90 Section 118.90 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.90 Bridges crossing channel obliquely. Bridges...

41 CFR 102-118.20 - Who is subject to this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who is subject to this part? 102-118.20 Section 102-118.20 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

14 CFR 1245.118 - Record of decisions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Record of decisions. 1245.118 Section 1245.118 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.118 Record of decisions. The findings of fact and...

14 CFR 1245.118 - Record of decisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Record of decisions. 1245.118 Section 1245.118 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.118 Record of decisions. The findings of fact and...

40 CFR 81.118 - Southwest Missouri Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Quality Control Region. 81.118 Section 81.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.118 Southwest Missouri Intrastate Air Quality Control Region. The Southwest Missouri Intrastate Air Quality Control Region consists of the territorial area encompassed by the...

40 CFR 81.118 - Southwest Missouri Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Quality Control Region. 81.118 Section 81.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.118 Southwest Missouri Intrastate Air Quality Control Region. The Southwest Missouri Intrastate Air Quality Control Region consists of the territorial area encompassed by the...

48 CFR 1371.118 - Changes-ship repair.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Changes-ship repair. 1371.118 Section 1371.118 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.118 Changes—ship repair. Insert clause...

41 CFR 102-118.290 - Must every electronic and paper transportation bill undergo a prepayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... and paper transportation bill undergo a prepayment audit? 102-118.290 Section 102-118.290 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation...

41 CFR 102-118.415 - Will the widespread mandatory use of prepayment audits eliminate postpayment audits?

Code of Federal Regulations, 2010 CFR

2010-07-01

... mandatory use of prepayment audits eliminate postpayment audits? 102-118.415 Section 102-118.415 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits...

41 CFR 102-118.400 - Must my agency renew a waiver of the prepayment audit requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... waiver of the prepayment audit requirements? 102-118.400 Section 102-118.400 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services...

49 CFR 176.118 - Electrical requirement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials are...

49 CFR 176.118 - Electrical requirement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 2 2011-10-01 2011-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials are...

49 CFR 176.118 - Electrical requirement.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 2 2012-10-01 2012-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials are...

49 CFR 176.118 - Electrical requirement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 2 2014-10-01 2014-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials are...

49 CFR 176.118 - Electrical requirement.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 2 2013-10-01 2013-10-01 false Electrical requirement. 176.118 Section 176.118... Requirements for Class 1 (Explosive) Materials Stowage § 176.118 Electrical requirement. (a) Electrical... person. (b) Electrical equipment and cables in a cargo space in which Class 1 (explosive) materials are...

19 CFR 118.3 - Written agreement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Written agreement. 118.3 Section 118.3 Customs... CENTRALIZED EXAMINATION STATIONS General Provisions § 118.3 Written agreement. The applicant tentatively selected to operate a CES must sign a written agreement with Customs before commencing operations. Failure...

19 CFR 118.3 - Written agreement.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Written agreement. 118.3 Section 118.3 Customs... CENTRALIZED EXAMINATION STATIONS General Provisions § 118.3 Written agreement. The applicant tentatively selected to operate a CES must sign a written agreement with CBP before commencing operations. Failure to...

7 CFR 900.118 - Costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Costs. 900.118 Section 900.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Meetings To Arbitrate and Mediate Disputes Relating to Sales of Milk or Its Products § 900.118 Costs. The...

33 CFR 118.140 - Painting bridge piers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Painting bridge piers. 118.140 Section 118.140 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.140 Painting bridge piers. The District Commander may require...

33 CFR 118.90 - Bridges crossing channel obliquely.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bridges crossing channel obliquely. 118.90 Section 118.90 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.90 Bridges crossing channel obliquely. Bridges...

View of Crewmembers in the SM during STS-118/Expedition 15 Farewell Ceremony

NASA Image and Video Library

2007-08-18

S118-E-09187 (18 Aug. 2007) --- The STS-118 and Expedition 15 crews gather for a farewell ceremony in the Zvezda Service Module of the International Space Station. Pictured are astronauts Barbara R. Morgan (foreground), Tracy Caldwell (left) and Rick Mastracchio, all STS-118 mission specialists; along with Scott Kelly (right), STS-118 commander. Hatches were closed between the station and Space Shuttle Endeavour at 4:10 p.m. on Aug. 18.

Characterization of Endogenous Plasmids from Lactobacillus salivarius UCC118▿ †

PubMed Central

Fang, Fang; Flynn, Sarah; Li, Yin; Claesson, Marcus J.; van Pijkeren, Jan-Peter; Collins, J. Kevin; van Sinderen, Douwe; O'Toole, Paul W.

2008-01-01

The genome of Lactobacillus salivarius UCC118 comprises a 1.83-Mb chromosome, a 242-kb megaplasmid (pMP118), and two smaller plasmids of 20 kb (pSF118-20) and 44 kb (pSF118-44). Annotation and bioinformatic analyses suggest that both of the smaller plasmids replicate by a theta replication mechanism. Furthermore, it appears that they are transmissible, although neither possesses a complete set of conjugation genes. Plasmid pSF118-20 encodes a toxin-antitoxin system composed of pemI and pemK homologs, and this plasmid could be cured when PemI was produced in trans. The minimal replicon of pSF118-20 was determined by deletion analysis. Shuttle vector derivatives of pSF118-20 were generated that included the replication region (pLS203) and the replication region plus mobilization genes (pLS208). The plasmid pLS203 was stably maintained without selection in Lactobacillus plantarum, Lactobacillus fermentum, and the pSF118-20-cured derivative strain of L. salivarius UCC118 (strain LS201). Cloning in pLS203 of genes encoding luciferase and green fluorescent protein, and expression from a constitutive L. salivarius promoter, demonstrated the utility of this vector for the expression of heterologous genes in Lactobacillus. This study thus expands the knowledge base and vector repertoire of probiotic lactobacilli. PMID:18390685

Trace elements in animal-based food from Shanghai markets and associated human daily intake and uptake estimation considering bioaccessibility.

PubMed

Lei, Bingli; Chen, Liang; Hao, Ying; Cao, Tiehua; Zhang, Xinyu; Yu, Yingxin; Fu, Jiamo

2013-10-01

The concentrations of four human essential trace elements [iron (Fe), manganese (Mn), zinc (Zn), chromium (Cr)] and non-essential elements [cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg)] in eighteen animal-based foods including meat, fish, and shellfish collected from markets in Shanghai, China, were analyzed, and the associated human daily intake and uptake considering bioaccessibility were estimated. The mean concentration ranges for eight trace elements measured in the foods were 3.98-131µgg(-1) for Fe, 0.437-18.5µgg(-1) for Mn, 5.47-53.8µgg(-1) for Zn, none detected-0.101µgg(-1) for Cr, 2.88×10(-4)-2.48×10(-2)µgg(-1) for Cd, 1.18×10(-3)-0.747µgg(-1) for Pb, none detected-0.498µgg(-1) for As, and 8.98×10(-4)-6.52×10(-2)µgg(-1) for Hg. The highest mean concentrations of four human essential elements were all found in shellfish. For all the trace elements, the observed mean concentrations are mostly in agreement with the reported values around the world. The total daily intake of trace elements via ingestion of animal-based food via an average Shanghai resident was estimated as 7371µgd(-1) for the human essential elements and 13.0µgd(-1) for the human non-essential elements, but the uptake decreased to 4826µgd(-1) and 6.90µgd(-1), respectively, after trace element bioaccessibility was considered. Livestock and fish for human essential and non-essential elements, respectively, were the main contributor, no matter whether the bioaccessibility was considered or not. Risk estimations showed that the intake and uptake of a signal trace element for an average Shanghai resident via ingestion animal-based foods from Shanghai markets do not exceed the recommended dietary allowance values; consequently, a health risk situation is not indicated. Copyright © 2013. Published by Elsevier Inc.

33 CFR 118.110 - Daymarks and lateral lighting on bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... bridges. 118.110 Section 118.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.110 Daymarks and lateral lighting on bridges. (a... through bridges with U.S. aids to navigation system lateral marks and lights installed on the...

41 CFR 102-118.30 - Are Government corporations bound by this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Are Government corporations bound by this part? 102-118.30 Section 102-118.30 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118...

41 CFR 102-118.5 - What is the purpose of this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is the purpose of this part? 102-118.5 Section 102-118.5 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

9 CFR 118.2 - Method of detention; Notifications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Method of detention; Notifications. 118.2 Section 118.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT...; SEIZURE AND CONDEMNATION § 118.2 Method of detention; Notifications. An authorized representative of the...

30 CFR 285.118 - What are my appeal rights?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are my appeal rights? 285.118 Section 285.118 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF General Provisions § 285.118...

7 CFR 1.18 - Fee schedule.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Fee schedule. 1.18 Section 1.18 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.18 Fee schedule. Pursuant to § 2.28 of this title, the Chief Financial Officer is delegated authority to promulgate regulations...

28 CFR 0.118 - Office of Chief Administrative Hearing Officer.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Officer. 0.118 Section 0.118 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Executive Office for Immigration Review § 0.118 Office of Chief Administrative Hearing... Law Judges in performance of their duties in accordance with 8 U.S.C. 1324 A and B. ...

21 CFR 133.118 - Colby cheese.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Colby cheese. 133.118 Section 133.118 Food and... CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.118 Colby cheese. (a) Colby cheese is the food prepared from milk and other ingredients...

21 CFR 20.118 - Advisory committee records.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Advisory committee records. 20.118 Section 20.118 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PUBLIC INFORMATION Availability of Specific Categories of Records § 20.118 Advisory committee records. All advisory...

41 CFR 102-118.440 - What are the postpayment audit responsibilities and roles of the GSA Audit Division?

Code of Federal Regulations, 2010 CFR

2010-07-01

... audit responsibilities and roles of the GSA Audit Division? 102-118.440 Section 102-118.440 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits...

41 CFR 102-118.275 - What must my agency consider when designing and implementing a prepayment audit program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... consider when designing and implementing a prepayment audit program? 102-118.275 Section 102-118.275 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation...

41 CFR 102-118.390 - On what basis does GSA grant a waiver to the prepayment audit requirement?

Code of Federal Regulations, 2010 CFR

2010-07-01

... grant a waiver to the prepayment audit requirement? 102-118.390 Section 102-118.390 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services...

41 CFR 102-118.430 - What information must be on my agency's transportation bills submitted for a postpayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... on my agency's transportation bills submitted for a postpayment audit? 102-118.430 Section 102-118.430 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment...

41 CFR 102-118.375 - Who has the authority to grant a waiver of the prepayment audit requirement?

Code of Federal Regulations, 2010 CFR

2010-07-01

... grant a waiver of the prepayment audit requirement? 102-118.375 Section 102-118.375 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services...

41 CFR 102-118.295 - What are the limited exceptions to every bill undergoing a prepayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... exceptions to every bill undergoing a prepayment audit? 102-118.295 Section 102-118.295 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services...

41 CFR 102-118.285 - What options for performing a prepayment audit does my agency have?

Code of Federal Regulations, 2010 CFR

2010-07-01

... performing a prepayment audit does my agency have? 102-118.285 Section 102-118.285 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services...

41 CFR 102-118.320 - What information must be on transportation bills that have completed my agency's prepayment audit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... on transportation bills that have completed my agency's prepayment audit? 102-118.320 Section 102-118.320 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of...

46 CFR 118.300 - Fire pumps.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300...

34 CFR 300.118 - Children in public or private institutions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Children in public or private institutions. 300.118 Section 300.118 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Least Restrictive Environment (lre) § 300.118...

"Astronaut STS-123 EVA 1, NBL Training"

NASA Image and Video Library

2007-04-18

• Event (Mission for flight / Class for training): STS-118 (13A.1) • Title: STS-118 EVA 1 NBL • Date: 4-18-07 • Location: NBL • Key words: 118, 13A.1, S5, NBL • Description: NBL underwater photos of STS-118 EVA 1 S5 install.

41 CFR 102-118.545 - What information must a TSP claim include?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What information must a TSP claim include? 102-118.545 Section 102-118.545 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118...

10 CFR 1.18 - Advisory Committee on Nuclear Waste.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Advisory Committee on Nuclear Waste. 1.18 Section 1.18 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Panels, Boards, and Committees § 1.18 Advisory Committee on Nuclear Waste. The Advisory Committee on...

10 CFR 1.18 - Advisory Committee on Nuclear Waste.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Advisory Committee on Nuclear Waste. 1.18 Section 1.18 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Panels, Boards, and Committees § 1.18 Advisory Committee on Nuclear Waste. The Advisory Committee on...

10 CFR 1.18 - Advisory Committee on Nuclear Waste.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Advisory Committee on Nuclear Waste. 1.18 Section 1.18 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Panels, Boards, and Committees § 1.18 Advisory Committee on Nuclear Waste. The Advisory Committee on...

10 CFR 1.18 - Advisory Committee on Nuclear Waste.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Advisory Committee on Nuclear Waste. 1.18 Section 1.18 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Panels, Boards, and Committees § 1.18 Advisory Committee on Nuclear Waste. The Advisory Committee on...

10 CFR 1.18 - Advisory Committee on Nuclear Waste.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Advisory Committee on Nuclear Waste. 1.18 Section 1.18 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Panels, Boards, and Committees § 1.18 Advisory Committee on Nuclear Waste. The Advisory Committee on...

31 CFR 11.8 - Reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Reports. 11.8 Section 11.8 Money and... FEDERAL PROPERTY UNDER THE CONTROL OF THE DEPARTMENT OF THE TREASURY § 11.8 Reports. This section... each fiscal year, each property managing bureau shall submit a report to the Director, Office of...

31 CFR 11.8 - Reports.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Reports. 11.8 Section 11.8 Money and... FEDERAL PROPERTY UNDER THE CONTROL OF THE DEPARTMENT OF THE TREASURY § 11.8 Reports. This section... each fiscal year, each property managing bureau shall submit a report to the Director, Office of...

31 CFR 11.8 - Reports.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Reports. 11.8 Section 11.8 Money and... FEDERAL PROPERTY UNDER THE CONTROL OF THE DEPARTMENT OF THE TREASURY § 11.8 Reports. This section... each fiscal year, each property managing bureau shall submit a report to the Director, Office of...

33 CFR 118.110 - Daymarks and lateral lighting on bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... bridges. 118.110 Section 118.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.110 Daymarks and lateral lighting on bridges. (a... through bridges with U.S. aids to navigation system lateral marks and lights installed on the...

19 CFR 118.13 - Notification of selection or nonselection.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Notification of selection or nonselection. 118.13 Section 118.13 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CENTRALIZED EXAMINATION STATIONS Application To Establish a CES § 118.13...

Altitude, age, and quality of groundwater, Papio-Missouri River Natural Resources District, eastern Nebraska, 1992 to 2009

USGS Publications Warehouse

McGuire, Virginia L.; Ryter, Derek W.; Flynn, Amanda S.

2012-01-01

The U.S. Geological Survey, in cooperation with the Papio-Missouri River Natural Resources District (PMRNRD), conducted this study to map the water-level altitude of 2009 within the Elkhorn River Valley, Missouri River Valley, and Platte River Valley alluvial aquifers; to present the predevelopment potentiometric-surface altitude within the Dakota aquifer; and to describe the age and quality of groundwater in the five principal aquifers of the PMRNRD in eastern Nebraska using data collected from 1992 to 2009. In addition, implications of alternatives to the current PMRNRD groundwater-quality monitoring approach are discussed. In the PMRNRD, groundwater altitude, relative to National Geodetic Vertical Datum of 1929, ranged from about 1,080 feet (ft) to 1,180 ft in the Elkhorn River Valley alluvial aquifer and from about 960 ft to 1,080 ft in the Missouri River Valley and Platte River Valley alluvial aquifers. In the PMRNRD, the estimated altitude of the potentiometric surface of the Dakota aquifer, predevelopment, ranged from about 1,100 ft to 1,200 ft. To assess groundwater age and quality, groundwater samples were collected from a total of 217 wells from 1992 to 2009 for analysis of various analytes. Groundwater samples collected in the PMRNRD from 1992 to 2009 and interpreted in this report were analyzed for age-dating analytes (chlorofluorocarbons), dissolved gases, major ions, trace elements, nutrients, stable isotope ratios, pesticides and pesticide degradates, volatile organic compounds, explosives, and 222radon. Apparent groundwater age was estimated from concentrations of chlorofluorocarbons measured in samples collected in 2000. Apparent groundwater-recharge dates ranged from older than 1940 in samples from wells screened in the Missouri River Valley alluvial aquifer to the early 1980s in samples from wells screened in the Dakota aquifer. Concentrations of major ions in the most recent sample per well collected from 1992 to 2009 indicate that the predominant water type was calcium bicarbonate. Samples from 4 wells exceeded the U.S. Environmental Protection Agency (USEPA) Secondary Drinking Water Regulation (SDWR) for sulfate [250 milligrams per liter (mg/L)], and samples from 4 wells exceeded the USEPA Drinking Water Advisory Table for sodium (30-60 mg/L). Eighteen of the 21 trace elements analyzed in samples from PMRNRD wells have USEPA drinking-water standards. Sixteen of the trace elements with USEPA standards were detected in the selected samples. In the samples selected for trace-element analysis, the only trace-element concentration that exceeded an enforceable USEPA drinking-water standard, the Maximum Contaminant Level (MCL), was for arsenic; arsenic concentration exceeded the USEPA MCL of 10 micrograms per liter (μg/L) in 4 percent of the samples. Trace-element concentrations that exceeded the USEPA SDWR or Lifetime Health Advisory level were iron (46 percent of the samples were greater than USEPA SDWR of 300 μg/L), manganese (70 percent of the samples were greater than USEPA SDWR of 50 μg/L), and strontium (4 percent of the samples were greater than USEPA Lifetime Health Advisory level of 4,000 μ/L). The concentration of nitrate plus nitrite as nitrogen (nitrate-N) in the most recent nutrient samples collected from the network wells and from one randomly selected well in the well nests from 1992 to 2009 for most wells (80 percent) ranged from less than 0.06 to 8.55 mg/L, with a median value of 0.12 mg/L. Concentrations of nitrate-N in 13 (7 percent) nutrient samples, 1992 to 2009, were greater than or equal to the USEPA MCL and Nebraska Title-118 standard of 10 mg/L, and concentrations of nitrate-N in 35 (18 percent) nutrient samples, 1992 to 2009, were greater than or equal to 5 mg/L, which is the PMRNRD action level for possible management implementation to reduce nitrate concentrations in groundwater. Of the 61 pesticides or pesticide degradates analyzed from 2007 to 2009, 21 were detected. Three of the 21 pesticides detected (alachlor, atrazine, and metolachlor) have established health-based criteria; all detections of these compounds were at concentrations less than their USEPA standards. From 2007 to 2009, 1 or more pesticide compounds were detected in 16 of the 82 network wells and in 18 of the 26 wells in well nests. From 2007 to 2009, the individual pesticide compounds that were detected most frequently were alachlor ethane sulfonic acid, a degradate of alachlor; deethylcyanazine acid, a degradate of cyanazine; and atrazine. Analytes with concentrations that exceeded 30 percent of the applicable Nebraska Title-118 standard were identified so that the PMRNRD can plan to monitor groundwater in the area and consider possible actions should the analyte concentrations continue to rise. The analytical results from the most recent samples collected in the network wells and all the wells in well nests from 1992 to 2009 indicate that, in at least 1 sample, there was a concentration that exceeded 30 percent of the Nebraska Title-118 standard for at least 1 of 3 major ions (chloride, fluoride, and sulfate), 1 nutrient (nitrate-N), 1 pesticide (atrazine), or 3 trace elements (arsenic, iron, and manganese). In addition, 30 percent of the USEPA MCL or Nebraska Title-118 standard for gross alpha activity likely was exceeded in samples from three wells screened in the Dakota aquifer. Study findings indicate that some alternatives to the current PMRNRD groundwater-sampling approach that could be considered are to collect fewer samples for nutrient analysis and to collect samples periodically for determining concentrations of additional analytes, particularly the analytes with concentrations that were at least 30 percent or more than the Nebraska Title-118 standard.

Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling

PubMed Central

North, Justin A.; Javaid, Sarah; Ferdinand, Michelle B.; Chatterjee, Nilanjana; Picking, Jonathan W.; Shoffner, Matthew; Nakkula, Robin J.; Bartholomew, Blaine; Ottesen, Jennifer J.; Fishel, Richard; Poirier, Michael G.

2011-01-01

Nucleosomes, the fundamental units of chromatin structure, are regulators and barriers to transcription, replication and repair. Post-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA processes. Histone H3(T118) is a site of phosphorylation [H3(T118ph)] and is implicated in regulation of transcription and DNA repair. We prepared H3(T118ph) by expressed protein ligation and determined its influence on nucleosome dynamics. We find H3(T118ph) reduces DNA–histone binding by 2 kcal/mol, increases nucleosome mobility by 28-fold and increases DNA accessibility near the dyad region by 6-fold. Moreover, H3(T118ph) increases the rate of hMSH2–hMSH6 nucleosome disassembly and enables nucleosome disassembly by the SWI/SNF chromatin remodeler. These studies suggest that H3(T118ph) directly enhances and may reprogram chromatin remodeling reactions. PMID:21576235

46 CFR 118.400 - Where required.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Where required. 118.400 Section 118.400 Shipping COAST... Extinguishing and Detecting Systems § 118.400 Where required. (a) The following spaces must be equipped with a... unoccupied space with a gross volume of not more than 170 cubic meters (6,000 cubic feet); (2) A pre...

32 CFR 724.118 - Documentary discharge review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Documentary discharge review. 724.118 Section 724.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NAVAL DISCHARGE REVIEW BOARD Definitions § 724.118 Documentary discharge review. A formal session of the NDRB convened for the purpose of reviewing, on the...

32 CFR 724.118 - Documentary discharge review.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Documentary discharge review. 724.118 Section 724.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NAVAL DISCHARGE REVIEW BOARD Definitions § 724.118 Documentary discharge review. A formal session of the NDRB convened for the purpose of reviewing, on the...

32 CFR 724.118 - Documentary discharge review.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Documentary discharge review. 724.118 Section 724.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NAVAL DISCHARGE REVIEW BOARD Definitions § 724.118 Documentary discharge review. A formal session of the NDRB convened for the purpose of reviewing, on the...

32 CFR 724.118 - Documentary discharge review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Documentary discharge review. 724.118 Section 724.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NAVAL DISCHARGE REVIEW BOARD Definitions § 724.118 Documentary discharge review. A formal session of the NDRB convened for the purpose of reviewing, on the...

32 CFR 724.118 - Documentary discharge review.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Documentary discharge review. 724.118 Section 724.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NAVAL DISCHARGE REVIEW BOARD Definitions § 724.118 Documentary discharge review. A formal session of the NDRB convened for the purpose of reviewing, on the...

14 CFR 1230.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Applications and proposals lacking definite plans for involvement of human subjects. 1230.118 Section 1230.118 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.118 Applications and proposals...

14 CFR 1230.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Applications and proposals lacking definite plans for involvement of human subjects. 1230.118 Section 1230.118 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PROTECTION OF HUMAN SUBJECTS § 1230.118 Applications and proposals...

33 CFR 118.130 - Fog signals.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Fog signals. 118.130 Section 118... LIGHTING AND OTHER SIGNALS § 118.130 Fog signals. On waterways where visibility is frequently reduced due... more fog signals to warn the navigator of the presence of the bridge. The fog signals must conform to...

33 CFR 118.130 - Fog signals.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Fog signals. 118.130 Section 118... LIGHTING AND OTHER SIGNALS § 118.130 Fog signals. On waterways where visibility is frequently reduced due... more fog signals to warn the navigator of the presence of the bridge. The fog signals must conform to...

41 CFR 102-118.315 - What must my agency do if the TSP disputes the findings and my agency cannot resolve the dispute?

Code of Federal Regulations, 2010 CFR

2010-07-01

...-118.315 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements for Prepayment Audits § 102-118.315 What must my...

41 CFR 102-118.380 - How does my agency apply for a waiver from a prepayment audit of requirement?

Code of Federal Regulations, 2010 CFR

2010-07-01

... for a waiver from a prepayment audit of requirement? 102-118.380 Section 102-118.380 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services...

41 CFR 102-118.535 - Are there principles governing my agency's TSP debt collection procedures?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Are there principles governing my agency's TSP debt collection procedures? 102-118.535 Section 102-118.535 Public Contracts and... REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Claims and Appeal Procedures General Agency...

27 CFR 21.118 - Methyl n-butyl ketone.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Methyl n-butyl ketone. 21.118 Section 21.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU....118 Methyl n-butyl ketone. (a) Acidity (as acetic acid). 0.02 percent by weight, maximum. (b) Color...

21 CFR 118.10 - Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan. 118.10 Section 118.10 Food and Drugs FOOD AND DRUG ADMINISTRATION... TRANSPORTATION OF SHELL EGGS § 118.10 Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention...

21 CFR 118.10 - Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan. 118.10 Section 118.10 Food and Drugs FOOD AND DRUG ADMINISTRATION... TRANSPORTATION OF SHELL EGGS § 118.10 Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention...

21 CFR 118.10 - Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan. 118.10 Section 118.10 Food and Drugs FOOD AND DRUG ADMINISTRATION... TRANSPORTATION OF SHELL EGGS § 118.10 Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention...

46 CFR 118.300 - Fire pumps.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300 Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On a...

46 CFR 118.600 - Fire axe.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire axe. 118.600 Section 118.600 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Additional Equipment § 118.600 Fire axe. A vessel of more than 19.8 meters (65 feet) in length must have at least one fire axe...

21 CFR 118.10 - Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan. 118.10 Section 118.10 Food and Drugs FOOD AND DRUG ADMINISTRATION... TRANSPORTATION OF SHELL EGGS § 118.10 Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention...

21 CFR 118.10 - Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention plan. 118.10 Section 118.10 Food and Drugs FOOD AND DRUG ADMINISTRATION... TRANSPORTATION OF SHELL EGGS § 118.10 Recordkeeping requirements for the Salmonella Enteritidis (SE) prevention...

32 CFR 701.118 - Privacy, IT, and PIAs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 5 2012-07-01 2012-07-01 false Privacy, IT, and PIAs. 701.118 Section 701.118... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.118 Privacy, IT, and PIAs. (a) Development. Privacy must be considered when requirements are being analyzed and decisions are being made...

32 CFR 701.118 - Privacy, IT, and PIAs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 5 2011-07-01 2011-07-01 false Privacy, IT, and PIAs. 701.118 Section 701.118... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.118 Privacy, IT, and PIAs. (a) Development. Privacy must be considered when requirements are being analyzed and decisions are being made...

32 CFR 701.118 - Privacy, IT, and PIAs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 5 2014-07-01 2014-07-01 false Privacy, IT, and PIAs. 701.118 Section 701.118... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.118 Privacy, IT, and PIAs. (a) Development. Privacy must be considered when requirements are being analyzed and decisions are being made...

32 CFR 701.118 - Privacy, IT, and PIAs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 5 2013-07-01 2013-07-01 false Privacy, IT, and PIAs. 701.118 Section 701.118... THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.118 Privacy, IT, and PIAs. (a) Development. Privacy must be considered when requirements are being analyzed and decisions are being made...

27 CFR 20.118 - Rubbing alcohol general-use formula.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (2) made in accordance with one of the two formulas prescribed in paragraph (b) of this section, and...-use formula. 20.118 Section 20.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Formulas and Statements of Process General-Use Formulas § 20.118 Rubbing alcohol general-use formula. (a...

27 CFR 20.118 - Rubbing alcohol general-use formula.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (2) made in accordance with one of the two formulas prescribed in paragraph (b) of this section, and...-use formula. 20.118 Section 20.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Formulas and Statements of Process General-Use Formulas § 20.118 Rubbing alcohol general-use formula. (a...

27 CFR 20.118 - Rubbing alcohol general-use formula.

Code of Federal Regulations, 2013 CFR

2013-04-01

... (2) made in accordance with one of the two formulas prescribed in paragraph (b) of this section, and...-use formula. 20.118 Section 20.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Formulas and Statements of Process General-Use Formulas § 20.118 Rubbing alcohol general-use formula. (a...

27 CFR 21.118 - Methyl n-butyl ketone.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Methyl n-butyl ketone. 21.118 Section 21.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU....118 Methyl n-butyl ketone. (a) Acidity (as acetic acid). 0.02 percent by weight, maximum. (b) Color...

33 CFR 118.130 - Fog signals.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Fog signals. 118.130 Section 118... LIGHTING AND OTHER SIGNALS § 118.130 Fog signals. On waterways where visibility is frequently reduced due... more fog signals to warn the navigator of the presence of the bridge. The fog signals must conform to...

33 CFR 118.130 - Fog signals.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Fog signals. 118.130 Section 118... LIGHTING AND OTHER SIGNALS § 118.130 Fog signals. On waterways where visibility is frequently reduced due... more fog signals to warn the navigator of the presence of the bridge. The fog signals must conform to...

33 CFR 118.130 - Fog signals.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Fog signals. 118.130 Section 118... LIGHTING AND OTHER SIGNALS § 118.130 Fog signals. On waterways where visibility is frequently reduced due... more fog signals to warn the navigator of the presence of the bridge. The fog signals must conform to...

33 CFR 118.65 - Lights on fixed bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on fixed bridges. 118.65 Section 118.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable...

33 CFR 118.70 - Lights on swing bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on swing bridges. 118.70 Section 118.70 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges. Each...

Pharmacological Consequence of the A118G Mu Opioid Receptor Polymorphism on Morphine- and Fentanyl-mediated Modulation of Ca2+ Channels in Humanized Mouse Sensory Neurons

PubMed Central

Mahmoud, Saifeldin; Thorsell, Annika; Sommer, Wolfgang H.; Heilig, Markus; Holgate, Joan K.; Bartlett, Selena E.; Ruiz-Velasco, Victor

2011-01-01

Background The most common functional single nucleotide polymorphism of the human OPRM1 gene, A118G, has been shown to be associated with inter-individual differences in opioid analgesic requirements, particularly with morphine, in patients with acute postoperative pain. The purpose of the present study was to examine whether this polymorphism would modulate the morphine and fentanyl pharmacological profile of sensory neurons isolated from a humanized mouse model homozygous for either the 118A or 118G allele. Methods The coupling of wild-type and mutant mu opioid receptors to voltage-gated Ca2+ channels after exposure to either ligand was examined by employing the whole-cell variant of the patch-clamp technique in acutely dissociated trigeminal ganglion neurons. Morphine-mediated antinociception was measured in mice carrying either the 118AA or 118GG allele. Results The biophysical parameters (cell size, current density, and peak current amplitude potential) measured from both groups of sensory neurons were not significantly different. In 118GG neurons, morphine was approximately 5-fold less potent and 26% less efficacious than that observed in 118AA neurons. On the other hand, the potency and efficacy of fentanyl were similar for both groups of neurons. Morphine-mediated analgesia in 118GG mice was significantly reduced compared to the 118AA mice. Conclusions This study provides evidence to suggest that the diminished clinical effect observed with morphine in 118G carriers results from an alteration of the receptor’s pharmacology in sensory neurons. Additionally, the impaired analgesic response with morphine may explain why carriers of this receptor variant have an increased susceptibility to become addicted to opioids. PMID:21926562

33 CFR 118.95 - Lights on structures not part of a bridge or approach structure.

Code of Federal Regulations, 2011 CFR

2011-07-01

... a bridge or approach structure. 118.95 Section 118.95 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.95 Lights on structures not part of a bridge or approach structure. Lights on sheer booms, isolated piers, obstructions, and other...

45 CFR 46.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Applications and proposals lacking definite plans for involvement of human subjects. 46.118 Section 46.118 Public Welfare Department of Health and Human... Research Subjects § 46.118 Applications and proposals lacking definite plans for involvement of human...

45 CFR 46.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Applications and proposals lacking definite plans for involvement of human subjects. 46.118 Section 46.118 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... Research Subjects § 46.118 Applications and proposals lacking definite plans for involvement of human...

45 CFR 46.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Applications and proposals lacking definite plans for involvement of human subjects. 46.118 Section 46.118 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... Research Subjects § 46.118 Applications and proposals lacking definite plans for involvement of human...

45 CFR 46.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Applications and proposals lacking definite plans for involvement of human subjects. 46.118 Section 46.118 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... Research Subjects § 46.118 Applications and proposals lacking definite plans for involvement of human...

41 CFR 102-118.60 - To what extent must my agency use electronic commerce?

Code of Federal Regulations, 2014 CFR

2014-01-01

... agency use electronic commerce? 102-118.60 Section 102-118.60 Public Contracts and Property Management... Services § 102-118.60 To what extent must my agency use electronic commerce? Your agency must use electronic commerce in all areas of your transportation program. This includes the use of electronic systems...

41 CFR 102-118.60 - To what extent must my agency use electronic commerce?

Code of Federal Regulations, 2011 CFR

2011-01-01

... agency use electronic commerce? 102-118.60 Section 102-118.60 Public Contracts and Property Management... Services § 102-118.60 To what extent must my agency use electronic commerce? Your agency must use electronic commerce in all areas of your transportation program. This includes the use of electronic systems...

41 CFR 102-118.60 - To what extent must my agency use electronic commerce?

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency use electronic commerce? 102-118.60 Section 102-118.60 Public Contracts and Property Management... Services § 102-118.60 To what extent must my agency use electronic commerce? Your agency must use electronic commerce in all areas of your transportation program. This includes the use of electronic systems...

41 CFR 102-118.60 - To what extent must my agency use electronic commerce?

Code of Federal Regulations, 2013 CFR

2013-07-01

... agency use electronic commerce? 102-118.60 Section 102-118.60 Public Contracts and Property Management... Services § 102-118.60 To what extent must my agency use electronic commerce? Your agency must use electronic commerce in all areas of your transportation program. This includes the use of electronic systems...

41 CFR 102-118.60 - To what extent must my agency use electronic commerce?

Code of Federal Regulations, 2012 CFR

2012-01-01

... agency use electronic commerce? 102-118.60 Section 102-118.60 Public Contracts and Property Management... Services § 102-118.60 To what extent must my agency use electronic commerce? Your agency must use electronic commerce in all areas of your transportation program. This includes the use of electronic systems...

6 CFR 11.8 - Suspension or revocation of eligibility for loans and loan guarantees, licenses, permits, or...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Suspension or revocation of eligibility for loans and loan guarantees, licenses, permits, or privileges. 11.8 Section 11.8 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS § 11.8 Suspension or revocation of...

29 CFR 825.116-825.118 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false [Reserved] 825.116-825.118 Section 825.116-825.118 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act §§ 825.116-825.118...

29 CFR 825.116-825.118 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false [Reserved] 825.116-825.118 Section 825.116-825.118 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act §§ 825.116-825.118...

29 CFR 825.116-825.118 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false [Reserved] 825.116-825.118 Section 825.116-825.118 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act §§ 825.116-825.118...

29 CFR 825.116-825.118 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false [Reserved] 825.116-825.118 Section 825.116-825.118 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act §§ 825.116-825.118...

29 CFR 825.116-825.118 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false [Reserved] 825.116-825.118 Section 825.116-825.118 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Coverage Under the Family and Medical Leave Act §§ 825.116-825.118...

41 CFR 102-118.540 - Who has the authority to audit, settle accounts, and/or start collection action for all...

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency? 102-118.540 Section 102-118.540 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who has the authority to...

21 CFR 118.9 - Administration of the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Administration of the Salmonella Enteritidis (SE) prevention plan. 118.9 Section 118.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... EGGS § 118.9 Administration of the Salmonella Enteritidis (SE) prevention plan. You must have one or...

21 CFR 118.9 - Administration of the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Administration of the Salmonella Enteritidis (SE) prevention plan. 118.9 Section 118.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... EGGS § 118.9 Administration of the Salmonella Enteritidis (SE) prevention plan. You must have one or...

21 CFR 118.9 - Administration of the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Administration of the Salmonella Enteritidis (SE) prevention plan. 118.9 Section 118.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... EGGS § 118.9 Administration of the Salmonella Enteritidis (SE) prevention plan. You must have one or...

21 CFR 118.9 - Administration of the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Administration of the Salmonella Enteritidis (SE) prevention plan. 118.9 Section 118.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... EGGS § 118.9 Administration of the Salmonella Enteritidis (SE) prevention plan. You must have one or...

21 CFR 118.9 - Administration of the Salmonella Enteritidis (SE) prevention plan.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Administration of the Salmonella Enteritidis (SE) prevention plan. 118.9 Section 118.9 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... EGGS § 118.9 Administration of the Salmonella Enteritidis (SE) prevention plan. You must have one or...

33 CFR 118.95 - Lights on structures not part of a bridge or approach structure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... a bridge or approach structure. 118.95 Section 118.95 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.95 Lights on structures not part of a bridge or approach structure. Lights on sheer booms, isolated piers, obstructions, and other...

41 CFR 102-118.460 - What is the time limit for my agency to file a court claim with a TSP for freight charges...

Code of Federal Regulations, 2010 CFR

2010-07-01

... the property? 102-118.460 Section 102-118.460 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is the time limit...

25 CFR 11.118 - What are the jurisdictional limitations of the Court of Indian Offenses?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false What are the jurisdictional limitations of the Court of Indian Offenses? 11.118 Section 11.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.118 What are...

25 CFR 11.118 - What are the jurisdictional limitations of the Court of Indian Offenses?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true What are the jurisdictional limitations of the Court of Indian Offenses? 11.118 Section 11.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.118 What are...

25 CFR 11.118 - What are the jurisdictional limitations of the Court of Indian Offenses?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What are the jurisdictional limitations of the Court of Indian Offenses? 11.118 Section 11.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.118 What are...

25 CFR 11.118 - What are the jurisdictional limitations of the Court of Indian Offenses?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What are the jurisdictional limitations of the Court of Indian Offenses? 11.118 Section 11.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Application; Jurisdiction § 11.118 What are...

41 CFR 102-118.590 - May my agency appeal a prepayment audit decision of the GSA Audit Division?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May my agency appeal a prepayment audit decision of the GSA Audit Division? 102-118.590 Section 102-118.590 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

41 CFR 102-118.335 - What does the GSA Audit Division consider when verifying an agency prepayment audit program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does the GSA Audit Division consider when verifying an agency prepayment audit program? 102-118.335 Section 102-118.335 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118...

41 CFR 102-118.580 - May a TSP appeal a prepayment audit decision of the GSA Audit Division?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May a TSP appeal a prepayment audit decision of the GSA Audit Division? 102-118.580 Section 102-118.580 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

Tetrahedral and polyhedral mesh evaluation for cerebral hemodynamic simulation--a comparison.

PubMed

Spiegel, Martin; Redel, Thomas; Zhang, Y; Struffert, Tobias; Hornegger, Joachim; Grossman, Robert G; Doerfler, Arnd; Karmonik, Christof

2009-01-01

Computational fluid dynamic (CFD) based on patient-specific medical imaging data has found widespread use for visualizing and quantifying hemodynamics in cerebrovascular disease such as cerebral aneurysms or stenotic vessels. This paper focuses on optimizing mesh parameters for CFD simulation of cerebral aneurysms. Valid blood flow simulations strongly depend on the mesh quality. Meshes with a coarse spatial resolution may lead to an inaccurate flow pattern. Meshes with a large number of elements will result in unnecessarily high computation time which is undesirable should CFD be used for planning in the interventional setting. Most CFD simulations reported for these vascular pathologies have used tetrahedral meshes. We illustrate the use of polyhedral volume elements in comparison to tetrahedral meshing on two different geometries, a sidewall aneurysm of the internal carotid artery and a basilar bifurcation aneurysm. The spatial mesh resolution ranges between 5,119 and 228,118 volume elements. The evaluation of the different meshes was based on the wall shear stress previously identified as a one possible parameter for assessing aneurysm growth. Polyhedral meshes showed better accuracy, lower memory demand, shorter computational speed and faster convergence behavior (on average 369 iterations less).

Observation of three-dimensional elemental distributions of a Si device using a 360 degrees -tilt FIB and the cold field-emission STEM system.

PubMed

Yaguchi, Toshie; Konno, Mitsuru; Kamino, Takeo; Watanabe, Masashi

2008-11-01

A technique for preparation of a pillar-shaped specimen and its multidirectional observation using a combination of a scanning transmission electron microscope (STEM) and a focused ion beam (FIB) instrument has been developed. The system employs an FIB/STEM compatible holder with a specially designed tilt mechanism, which allows the specimen to be tilted through 360 degrees [T. Yaguchi, M. Konno, T. Kamino, T. Hashimoto, T. Ohnishi, K. Umemura, K. Asayama, Microsc. Microanal. 9 (Suppl. 2) (2003) 118; T. Yaguchi, M. Konno, T. Kamino, T. Hashimoto, T. Ohnishi, M. Watanabe, Microsc. Microanal. 10 (Suppl. 2) (2004) 1030]. This technique was applied to obtain the three-dimensional (3D) elemental distributions around a contact plug of a Si device used in a 90-nm technology. A specimen containing only one contact plug was prepared in the shape of a pillar with a diameter of 200nm and a length of 5mum. Elemental maps were obtained from the pillar specimen using a 200-kV cold-field emission gun (FEG) STEM model HD-2300C equipped with the EDAX genesis X-ray energy-dispersive spectrometry (XEDS) system through a spectrum imaging technique. In this study, elemental distributions of minor elements with weak signals were enhanced by applying principal component analysis (PCA), which is a superior technique to extract weak signals from a large dataset. The distributions of elements, especially the metallization component Ti and minor dopant As in this particular device, were successfully extracted by PCA. Finally, the 3D elemental distributions around the contact plug could be visualized by reconstruction from the tilt series of maps.

The dome-shaped Fresnel-Köhler concentrator

NASA Astrophysics Data System (ADS)

Zamora, P.; Benitez, P.; Li, Y.; Miñano, J. C.; Mendes-Lopes, J.; Araki, K.

2012-10-01

Manufacturing tolerances, along with a high concentration ratio, are key issues in order to obtain cheap CPV systems for mass production. Consequently, this manuscript presents a novel tolerant and cost effective concentrator optic: the domed-shaped Fresnel-Köhler, presenting a curved Fresnel lens as Primary Optical Element (POE). This concentrator is based on two previous successful CPV designs: the FK concentrator, based on a flat Fresnel lens, and the dome-shaped Fresnel lens system developed by Daido Steel, resulting on a superior concentrator. The manuscript shows outstanding simulation results for geometrical concentration factor of Cg = 1,230x: high tolerance and high optical efficiency, achieving acceptance angles of 1.18° (dealing to a CAP*=0.72) and efficiencies over 85% (without any anti-reflective coating). Moreover, Köhler integration provides good irradiance uniformity on the cell surface without increasing system complexity by means of any extra element. Daido Steel advanced technique for demolding injected plastic pieces will allow for easy manufacture of the dome-shaped POE of DFK concentrator.

Relativistic Prolapse-Free Gaussian Basis Sets of Quadruple-ζ Quality: (aug-)RPF-4Z. III. The f-Block Elements.

PubMed

Teodoro, Tiago Quevedo; Visscher, Lucas; da Silva, Albérico Borges Ferreira; Haiduke, Roberto Luiz Andrade

2017-03-14

The f-block elements are addressed in this third part of a series of prolapse-free basis sets of quadruple-ζ quality (RPF-4Z). Relativistic adapted Gaussian basis sets (RAGBSs) are used as primitive sets of functions while correlating/polarization (C/P) functions are chosen by analyzing energy lowerings upon basis set increments in Dirac-Coulomb multireference configuration interaction calculations with single and double excitations of the valence spinors. These function exponents are obtained by applying the RAGBS parameters in a polynomial expression. Moreover, through the choice of C/P characteristic exponents from functions of lower angular momentum spaces, a reduction in the computational demand is attained in relativistic calculations based on the kinetic balance condition. The present study thus complements the RPF-4Z sets for the whole periodic table (Z ≤ 118). The sets are available as Supporting Information and can also be found at http://basis-sets.iqsc.usp.br .

The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress.

PubMed

Martino, Thiago; Kudrolli, Tarana A; Kumar, Binod; Salviano, Isis; Mencalha, André; Coelho, Marsen Garcia P; Justo, Graça; Costa, Paulo R Ribeiro; Sabino, Kátia C Carvalho; Lupold, Shawn E

2018-02-01

The targeted induction of reactive oxygen species (ROS) is a developing mechanism for cancer therapy. LQB-118 is a pterocarpanquinone and ROS-inducing agent with proven antineoplastic activity. Here, LQB-118 efficacy and mechanism of activity, were examined in Prostate Cancer (PCa) cell and tumor models. PC3, LNCaP, and LAPC4 PCa cells were applied. Dicoumarol treatment was used to inhibit quinone reductase activity. N-acetylcysteine (NAC) was applied as a ROS scavenger. ROS production was quantified by H 2 DCFDA flow cytometry. LQB-118 treated cells were evaluated for changes in lipid peroxidation, viability, and apoptosis. Treatment-induced gene expression was measured by RT-qPCR and Western Blot. SOD1 knockdown was achieved with siRNA or miRNA mimic transfection. MicroRNA specificity was determined by 3'UTR reporter assay. Oral LQB-118 treatment (10 mg/kg/day) efficacy was determined in athymic male nude mice bearing subcutaneous PC3 xenograft tumors. LQB-118 treatment triggered PCa cell death and apoptosis. Therapeutic activity was at least partially dependent upon quinone reduction and ROS generation. LQB-118 treatment caused an increase in cellular ROS and lipid peroxidation. Treated cells exhibited elevated levels of NQO1, Nrf2, and SOD1. The miRNAs miR-206, miR-1, and miR-101 targeted and reduced SOD1 expression. The knockdown of SOD1, by siRNA or miRNA, enhanced LQB-118 cytotoxicity. Orally administered LQB-118 treatment significantly reduced the growth of established PCa xenograft tumors. LQB-118 is a developing and orally active pterocarpanquinone agent that effectively kills PCa cells through quinone reduction and ROS generation. The inhibition SOD1 expression enhances LQB-118 activity, presumably by impairing the cellular antioxidant response. © 2017 Wiley Periodicals, Inc.

Endotoxin-neutralizing activity and mechanism of action of a cationic α-helical antimicrobial octadecapeptide derived from α-amylase of rice.

PubMed

Taniguchi, Masayuki; Ochiai, Akihito; Matsushima, Kenta; Tajima, Koji; Kato, Tetsuo; Saitoh, Eiichi; Tanaka, Takaaki

2016-01-01

We have previously reported that AmyI-1-18, an octadecapeptide derived from α-amylase (AmyI-1) of rice, is a novel cationic α-helical peptide that exhibited antimicrobial activity against human pathogens, including Porphyromonas gingivalis, Pseudomonas aeruginosa, Propionibacterium acnes, Streptococcus mutans, and Candida albicans. In this study, to further investigate the potential functions of AmyI-1-18, we examined its inhibitory ability against the endotoxic activities of lipopolysaccharides (LPSs, smooth and Rc types) and lipid A from Escherichia coli. AmyI-1-18 inhibited the production of endotoxin-induced nitric oxide (NO), an inflammatory mediator, in mouse macrophages (RAW264) in a concentration-dependent manner. The results of a chromogenic Limulus amebocyte lysate assay illustrated that the ability [50% effective concentration (EC50): 0.17 μM] of AmyI-1-18 to neutralize lipid A was similar to its ability (EC50: 0.26 μM) to neutralize LPS, suggesting that AmyI-1-18 specifically binds to the lipid A moiety of LPS. Surface plasmon resonance analysis of the interaction between AmyI-1-18 and LPS or lipid A also suggested that AmyI-1-18 directly binds to the lipid A moiety of LPS because the dissociation constant (KD) of AmyI-1-18 with lipid A is 5.6×10(-10) M, which is similar to that (4.3×10(-10) M) of AmyI-1-18 with LPS. In addition, AmyI-1-18 could block the binding of LPS-binding protein to LPS, although its ability was less than that of polymyxin B. These results suggest that AmyI-1-18 expressing antimicrobial and endotoxin-neutralizing activities is useful as a safe and potent host defense peptide against pathogenic Gram-negative bacteria in many fields of healthcare. Copyright © 2015 Elsevier Inc. All rights reserved.

Stability study of the anticonvulsant enaminone (E118) using HPLC and LC-MS.

PubMed

Abdel-Hamid, Mohammed E; Edafiogho, Ivan O; Hamza, Huda M

2002-01-01

The stability of the new chemical synthetic enaminone derivative (E118) was investigated using a stability-indicating high-performance liquid chromatography (HPLC) procedure. The examined samples were analyzed using a chiral HSA column and a mobile phase (pH 7.5) containing n-octanoic acid (5 mM), isopropyl alcohol and 100 mM disodium hydrogen phosphate solution (1:9 v/v) at a flow rate of 1 ml min(-1). The developed method was specific, accurate and reproducible. The HPLC chromatograms exhibited well-resolved peaks of E118 and the degradation products at retention times <5 min. The stability of E118 was performed in 0.1 M hydrochloric acid, 0.1 M sodium hydroxide, water/ethanol (1:1) and phosphate buffer (pH approximately 7.5) solutions. E118 was found to undergo fast hydrolysis in 0.1 M hydrochloric acid solution. The decomposition of E118 followed first order kinetics under the experimental conditions. The results confirmed that protonation of the enaminone system in the molecule enhanced the hydrolysis of E118 at degradation rate constant of 0.049 min(-1) and degradation half-life of 14.1 min at 25 degrees C. However, E118 was significantly stable in 0.1 M sodium hydroxide, physiological phosphate buffer (pH 7.5) and ethanol/water (1:1) solutions. The degradation rate constants and degradation half-lives were in the ranges 0.0023-0.0086 h(-1) and 80.6-150.6 h, respectively. Analysis of the acid-induced degraded solution of E118 by liquid chromatography-mass spectrometry (LC-MS) revealed at least two degradation products of E118 at m/z 213.1 and 113.1, respectively.

Near East/North Africa Report, Number 2603

DTIC Science & Technology

1982-08-17

Electricity Stations 118 Gum Arabic Belt 118 Popular Development 118 Foreign Exchange Regulating Measures 118 Tombura on HEC Policy 119...Middle East and that this underlines the need for a just solution to the Palestinian problem—a solution that guar - antees the legitimate rights of the...last months of 1360. It must be noted that prices of a number of goods & services, such as cold drinks, washing powder , some cigarettes and telephone

The LIC Planners’s Guide (LPG)

DTIC Science & Technology

1992-03-01

administrative and contract law . 2. ASSIST IN CRIMINAL LAW: Assist Host Nation/Allied governments in filing and processing cases for redress of property and...forces to assist in administrative/ contract law , assist in criminal law, assist in claims, provide legal assistance, and to provide assistance in...SERVICES (LFA): 11-8 ASSIST IN ADMINISTRATIVE/ CONTRACT LAW : 11-8 ASSIST IN CLAIMS: 11-8 ASSIST IN CRIMINAL LAW: 11-8 PROVIDE INTERNATIONAL LAW

Functional Mu Opioid Receptor Polymorphism (OPRM1 A118G) Associated With Heroin Use Outcomes in Caucasian Males: A Pilot Study

PubMed Central

Woodcock, Eric A.; Lundahl, Leslie H.; Burmeister, Margit; Greenwald, Mark K.

2017-01-01

Background Heroin’s analgesic, euphoric and dependence-producing effects are primarily mediated by the mu opioid receptor (MOR). A single gene, OPRM1, encodes the MOR. The functional polymorphism A118G, located in exon 1 of the OPRM1 gene, results in anatomically-specific reductions in MOR expression, which may alter an individual’s response to heroin. In prior studies 118G (rare allele) carriers demonstrated significantly greater opioid tolerance, overdose vulnerability, and pain sensitivity than 118AA homozygotes. Those findings suggest OPRM1 genotype may impact characteristics of heroin use. Methods The present pilot study characterized the impact of OPRM1 genotype (rs1799971, 118G allele carriers vs. 118AA homozygotes) on heroin-use phenotypes associated with heroin dependence severity in a sample of male, Caucasian chronic heroin users (n = 86). Results Results indicate that 118G allele carriers reported significantly more heroin use-related consequences and heroin-quit attempts, and were more likely to have sought treatment for their heroin use than 118AA homozygotes. Conclusions These preliminary findings, consistent with extant data, illustrate a role for OPRM1 allelic variation on heroin use characteristics, and provide support for considering genotype in heroin treatment and relapse prevention. PMID:25911999

Closure Report for Corrective Action Unit 118: Area 27 Super Kukla Facility, Nevada Test Site, Nevada with ROTC 1, Revision 0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mark Burmeister

2007-09-01

This CR provides documentation and justification for the closure of CAU 118 without further corrective action. This justification is based on process knowledge and the results of the investigative and closure activities conducted in accordance with the CAU 118 SAFER Plan: Streamlined Approach for Environmental Restoration (SAFER) Plan for CAU 118: Area 27 Super Kukla Facility, Nevada Test Site, Nevada (NNSA/NSO, 2006). The SAFER Plan provides information relating to site history as well as the scope and planning of the investigation. This CR also provides the analytical and radiological survey data to confirm that the remediation goals were met asmore » specified in the CAU 118 SAFER Plan (NNSA/NSO, 2006). The Nevada Division of Environmental Protection (NDEP) approved the CAU 118 SAFER Plan (Murphy, 2006), which recommends closure in place with use restrictions (URs).« less

Superheavy nuclei from 48Ca-induced reactions

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Utyonkov, V. K.

2015-12-01

The discovery and investigation of the new region of superheavy nuclei at the DGFRS separator based on fusion reactions of 48Ca with 238U-249Cf target nuclei are reviewed. The production cross sections and summaries of the decay properties, including the results of the posterior experiments performed at the SHIP, BGS, and TASCA separators, as well as at the chemistry setups, are discussed and compared with the theoretical calculations and the systematic trends in the α-decay and spontaneous fission properties. The properties of the new nuclei, isotopes of elements 112-118, and their decay products demonstrate significant increases in the stability of the heaviest nuclei with increasing neutron number and closer approach to magic number N = 184.

Validation of Hansen-Roach library for highly enriched uranium metal systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wenz, T.R.; Busch, R.D.

The Hansen-Roach 16-group cross-section library has been validated for use in pure uranium metal systems by modeling the Godiva critical assembly using the neutronics transport theory code ONEDANT to perform effective multiplication factor (k{sub eff}) calculations. The cross-section library used contains data for 118 isotopes (34 unique elements), including the revised cross sections for {sup 235}U and {sup 238}U. The Godiva critical assembly is a 17.4-cm sphere composed of 93.7 wt% {sup 235}U, 1.0 wt% {sup 234}U, and 5.3 wt% {sup 238}U with an effective homogeneous density of 18.7 g/cm{sup 3}.

40 CFR 265.118 - Post-closure plan; amendment of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the wastes, application of advanced technology, or alternative disposal, treatment, or re-use.... 265.118 Section 265.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) INTERIM STATUS STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT...

Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters.

PubMed

Costa, Luciana; Pinheiro, Roberta O; Dutra, Patrícia M L; Santos, Rosiane F; Cunha-Júnior, Edézio F; Torres-Santos, Eduardo C; da Silva, Alcides J M; Costa, Paulo R R; Da-Silva, Silvia A G

2014-01-01

Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model. The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania (Viannia) braziliensis, which is the major Leishmania species related to American tegumentary leishmaniasis. The in vitro antileishmanial activity of LQB-118 on L. braziliensis was tested on the promastigote and intracellular amastigote forms. The cell death induced by LQB-118 in the L. braziliensis promastigotes was analyzed using an annexin V-FITC/PI kit, the oxidative stress was evaluated by 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) and the ATP content by luminescence. In situ labeling of DNA fragments by terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) was used to investigate apoptosis in the intracellular amastigotes. L. braziliensis-infected hamsters were treated from the seventh day of infection with LQB-118 administered intralesionally (26 µg/kg/day, three times a week) or orally (4,3 mg/kg/day, five times a week) for eight weeks. LQB-118 was active against the L. braziliensis promastigotes and intracellular amastigotes, producing IC50 (50% inhibitory concentration) values of 3,4±0,1 and 7,5±0,8 µM, respectively. LQB-118 induced promastigote phosphatidylserine externalization accompanied by increased reactive oxygen species production and ATP depletion. Intracellular amastigote DNA fragmentation was also observed, without affecting the viability of macrophages. The treatment of L. braziliensis-infected hamsters with LQB-118, either orally or intralesionally, was effective in the control of lesion size, parasite load and increase intradermal reaction to parasite antigen. Taken together, these results show that the antileishmanial effect of LQB-118 extends to L. braziliensis in the hamster model, involves the induction of parasite apoptosis and shows promising therapeutic option by oral or local routes in leishmaniasis.

Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters

PubMed Central

Costa, Luciana; Pinheiro, Roberta O.; Dutra, Patrícia M. L.; Santos, Rosiane F.; Cunha-Júnior, Edézio F.; Torres-Santos, Eduardo C.; da Silva, Alcides J. M.; Costa, Paulo R. R.; Da-Silva, Silvia A. G.

2014-01-01

Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model. The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania (Viannia) braziliensis, which is the major Leishmania species related to American tegumentary leishmaniasis. The in vitro antileishmanial activity of LQB-118 on L. braziliensis was tested on the promastigote and intracellular amastigote forms. The cell death induced by LQB-118 in the L. braziliensis promastigotes was analyzed using an annexin V-FITC/PI kit, the oxidative stress was evaluated by 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA) and the ATP content by luminescence. In situ labeling of DNA fragments by terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) was used to investigate apoptosis in the intracellular amastigotes. L. braziliensis-infected hamsters were treated from the seventh day of infection with LQB-118 administered intralesionally (26 µg/kg/day, three times a week) or orally (4,3 mg/kg/day, five times a week) for eight weeks. LQB-118 was active against the L. braziliensis promastigotes and intracellular amastigotes, producing IC50 (50% inhibitory concentration) values of 3,4±0,1 and 7,5±0,8 µM, respectively. LQB-118 induced promastigote phosphatidylserine externalization accompanied by increased reactive oxygen species production and ATP depletion. Intracellular amastigote DNA fragmentation was also observed, without affecting the viability of macrophages. The treatment of L. braziliensis-infected hamsters with LQB-118, either orally or intralesionally, was effective in the control of lesion size, parasite load and increase intradermal reaction to parasite antigen. Taken together, these results show that the antileishmanial effect of LQB-118 extends to L. braziliensis in the hamster model, involves the induction of parasite apoptosis and shows promising therapeutic option by oral or local routes in leishmaniasis. PMID:25340550

Hydrolysis and photolysis of diacylhydrazines-type insect growth regulator JS-118 in aqueous solutions under abiotic conditions.

PubMed

Hu, J-Y; Liu, C; Zhang, Y-C; Zheng, Z-X

2009-05-01

JS-118 is a diacylhydrazines-type insect growth regulator which is now used extensively in China. The hydrolysis and photolysis of the pesticide JS-118 in aqueous solutions have been assessed under natural and controlled conditions in this project. Hydrolysis experimental results show that JS-118 is quite stable in aqueous solutions in dark, with no significant variations be observed in degradation under various conditions. Abiotic hydrolysis is relatively unimportant compared to photolysis. The rate of photodecomposition of JS-118 in aqueous solutions follows first-order kinetics both in UV radiation and natural sunlight. The degradation rates are faster under UV light than sunlight, with the half-lives (t (1/2) = ln2/k) of 6.00-10.85 min and 6.63-10.16 day, respectively. Under UV light, two major photoproducts are detected, and tentatively identified according to HPLC-MS spectral information as N-t-butyl-N-(3,5-dimethylbenzoyl) and 3,7-dimethyl-benzoatedihydrofuran. The corresponding photolysis pathways of JS-118 are also proposed. The results obtained indicate that direct photoreaction is an important dissipation pathway of JS-118 in natural water systems.

Dietary intake of trace elements, minerals, and vitamins of patients on chronic hemodialysis.

PubMed

Bossola, Maurizio; Di Stasio, Enrico; Viola, Antonella; Leo, Alessandra; Carlomagno, Giusy; Monteburini, Tania; Cenerelli, Stefano; Santarelli, Stefano; Boggi, Rolando; Miggiano, Giacinto; Vulpio, Carlo; Mele, Cristina; Tazza, Luigi

2014-04-01

We aimed to estimate dietary intakes of trace elements, minerals, and vitamins in hemodialysis patients (HDP) of three centers in one metropolitan and two urban areas of Italy. Daily dietary intake was assessed using a 3-day diet diary in 128 HDP. Mean daily intakes of trace elements were as follows: zinc, 7.6 ± 5.4 mg; copper, 14.3 ± 11.8 mg; selenium, 28.3 ± 18.1 μg; and iron, 7.2 ± 4.1 mg (7.8 ± 2.6 mg in women, 6.9 ± 2.4 mg in men). The distribution of patients by daily intakes of trace elements showed most were under the recommended values, with the exception of copper intake, which was much higher. Mean daily intakes of minerals were as follows: magnesium, 174.4 ± 94.3 mg; phosphorus, 842.6 ± 576.8 mg; calcium, 371.8 ± 363.7 mg; potassium, 1,616.2 ± 897.3 mg; and sodium, 1,350 ± 1,281 mg. Mean daily intakes of vitamins were as follows: vitamin A, 486.1 ± 544.6 μg; vitamin B1, 0.86 ± 0.7 mg; vitamin B2, 1.1 ± 0.7 mg; vitamin B3, 13.3 ± 8.1 mg; vitamin C, 47.8 ± 50.3 mg; and vitamin E, 9.5 ± 3.6 mg. The distribution of patients by daily intakes of vitamins showed most were under the recommended values. Daily intakes of trace elements and vitamins were similar among the three centers and did not differ between dialysis and non-dialysis days. Many HDP have daily dietary intakes of trace elements and vitamins below the recommended values, whereas the intake of copper is much higher.

Anatomical, chemical, and ecological factors affecting tree species choice in dendrochemistry studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cutter, B.E.; Guyette, R.P.

1993-07-01

Recently, element concentrations in tree rings have been used to monitor metal contamination, fertilization, and the effects of acid precipitation on soils. This has stimulated interest in which tree species may be suitable for use in studies of long-term trends in environmental chemistry. Potential radial translocation of elements across living boundaries can be a confounding factor in assessing environmental change. The selection of species which minimizes radial translocation of elements can be critical to the success of dendrochemical research. Criteria for selection of species with characteristics favorable for dendrochemical analysis are categorized into (1) habitat-based factors, (2) xylem-based factors, andmore » (3) element-based factors. A wide geographic range and ecological amplitude provide an advantage in calibration and better controls on the effects of soil chemistry. The most important xylem-based criteria are heartwood moisture content, permeability, and the nature of the sapwood-heartwood transition. The element of interest is important in determining suitable tree species because all elements are not equally mobile or detectable in the xylem. Ideally, the tree species selected for dendrochemical study will be long-lived, grow on a wide range of sites over a large geographic distribution, have a distinct heartwood with a low number of rings in the sapwood, a low heartwood moisture content, and have low radial permeability. Recommended temperate zone North American species include white oak (Quercus alba L.), post oak (Q. stellate Wangenh.), eastern redcedar (funiperus virginiana L.), old-growth Douglas-fir [Pseudoaugu menziesii (Mirb.) Franco] and big sagebrush (Artemisia tridentata Nutt.). In addition, species such as bristlecone pine (Pinus aristata Engelm. syn. longaeva), old-growth redwood [Sequoia sempervirens (D. Don) Endl.], and giant sequoia [S. gigantea (Lindl.) Deene] may be suitable for local purposes. 118 refs., 2 tabs.« less

7 CFR 1280.118 - Promotion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... information and public relations with emphasis on new marketing strategies, to present a favorable image of U... 7 Agriculture 10 2010-01-01 2010-01-01 false Promotion. 1280.118 Section 1280.118 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS...

9 CFR 3.118 - Handling.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Handling. 3.118 Section 3.118 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Marine...

9 CFR 3.118 - Handling.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Handling. 3.118 Section 3.118 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Marine...

9 CFR 3.118 - Handling.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Handling. 3.118 Section 3.118 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Marine...

9 CFR 3.118 - Handling.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Handling. 3.118 Section 3.118 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Marine...

9 CFR 3.118 - Handling.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Handling. 3.118 Section 3.118 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Marine...

STS-118/Expedition 15 Crewmembers greet one another after Hatch Opening

NASA Image and Video Library

2007-08-10

S118-E-06097 (10 Aug. 2007) --- Barbara R. Morgan, STS-118 mission specialist, participates in what looks like a photographers' convention in the Destiny lab onboard the International Space Station. Her two "fellow delegates" are astronaut Alvin Drew (center), STS-118 mission specialist, and astronaut Clay Anderson, Expedition 15 flight engineer. The photo was taken not long after the hatches were open on the orbital outpost, an action that allowed the station's population to surge from three to ten in short order.

Influence of adhesion and bacteriocin production by Lactobacillus salivarius on the intestinal epithelial cell transcriptional response.

PubMed

O'Callaghan, John; Buttó, Ludovica F; MacSharry, John; Nally, Kenneth; O'Toole, Paul W

2012-08-01

Lactobacillus salivarius strain UCC118 is a human intestinal isolate that has been extensively studied for its potential probiotic effects in human and animal models. The objective of this study was to determine the effect of L. salivarius UCC118 on gene expression responses in the Caco-2 cell line to improve understanding of how the strain might modulate intestinal epithelial cell phenotypes. Exposure of Caco-2 cells to UCC118 led to the induction of several human genes (TNFAIP3, NFKBIA, and BIRC3) that are negative regulators of inflammatory signaling pathways. Induction of chemokines (CCL20, CXCL-1, and CXCL-2) with antimicrobial functions was also observed. Disruption of the UCC118 sortase gene srtA causes reduced bacterial adhesion to epithelial cells. Transcription of three mucin genes was reduced significantly when Caco-2 cells were stimulated with the ΔsrtA derivative of UCC118 compared to cells stimulated with the wild type, but there was no significant change in the transcription levels of the anti-inflammatory genes. UCC118 genes that were significantly upregulated upon exposure to Caco-2 cells were identified by bacterial genome microarray and consisted primarily of two groups of genes connected with purine metabolism and the operon for synthesis of the Abp118 bacteriocin. Following incubation with Caco-2 cells, the bacteriocin synthesis genes were transcribed at higher levels in the wild type than in the ΔsrtA derivative. These data indicate that L. salivarius UCC118 influences epithelial cells both through modulation of the inflammatory response and by modulation of intestinal cell mucin production. Sortase-anchored cell surface proteins of L. salivarius UCC118 have a central role in promoting the interaction between the bacterium and epithelial cells.

41 CFR 102-118.40 - How does my agency order transportation and transportation services?

Code of Federal Regulations, 2011 CFR

2011-01-01

... orders: (a) Transportation of freight and household goods and related transportation services (e.g.... Government Passenger Transportation—Handbook,” obtainable from: General Services Administration... transportation and transportation services? 102-118.40 Section 102-118.40 Public Contracts and Property...

41 CFR 102-118.40 - How does my agency order transportation and transportation services?

Code of Federal Regulations, 2010 CFR

2010-07-01

... orders: (a) Transportation of freight and household goods and related transportation services (e.g.... Government Passenger Transportation—Handbook,” obtainable from: General Services Administration... transportation and transportation services? 102-118.40 Section 102-118.40 Public Contracts and Property...

27 CFR 479.118 - Proof of exportation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Proof of exportation. 479.118 Section 479.118 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.118 - Proof of exportation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Proof of exportation. 479.118 Section 479.118 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.118 - Proof of exportation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Proof of exportation. 479.118 Section 479.118 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.118 - Proof of exportation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Proof of exportation. 479.118 Section 479.118 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

27 CFR 479.118 - Proof of exportation.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Proof of exportation. 479.118 Section 479.118 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION MACHINE GUNS, DESTRUCTIVE DEVICES, AND CERTAIN...

10 CFR 51.118 - Final environmental impact statement-notice of availability.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Final environmental impact statement-notice of availability. 51.118 Section 51.118 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act...

24 CFR 4001.118 - Equity sharing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Equity sharing. 4001.118 Section 4001.118 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) BOARD OF DIRECTORS OF THE HOPE FOR HOMEOWNERS PROGRAM HOPE FOR HOMEOWNERS PROGRAM Eligibility...

9 CFR 118.4 - Seizure and condemnation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Seizure and condemnation. 118.4 Section 118.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS DETENTION; SEIZURE AND...

Leucocytes DNA damage in mice exposed to JS-118 by the comet assay.

PubMed

Zhang, Tao; Hu, Jiye; Zhang, Yuchao; Zhao, Qianfei; Ning, Jun

2011-09-01

JS-118 is an extensively used insecticide in China. The present study investigated the genotoxic effect of JS-118 on whole blood at 24, 48, 72 and 96 h by using alkaline comet assay. Male Kunming mice were given 6.25, 12.5, 25, 50 and 100 mg/kg BW of JS-118 intraperitoneally. A statistically significant increase in all comet parameters indicating DNA damage was observed at 24 h post-treatment (p < 0.05). A clear concentration-dependent increase of DNA damage was revealed as evident by the OTM (arbitrary units), tail length (µm) and tail DNA (%). From 48 h post-treatment, a gradual decrease in mean comet parameters was noted. By 96 h of post-treatment, the mean comet tail length reached control levels indicating repair of damaged DNA. This study on mice showed different DNA damage depending on the concentration of JS-118 and the period of treatment. The present study provided further information of the potential risk of the genetic damage caused by JS-118.

37 CFR 11.8 - Oath and registration fee.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Oath and registration fee. 11.8 Section 11.8 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE REPRESENTATION OF OTHERS BEFORE THE UNITED STATES PATENT AND TRADEMARK OFFICE...

40 CFR 93.118 - Criteria and procedures: Motor vehicle emissions budget.

Code of Federal Regulations, 2010 CFR

2010-07-01

... emissions budget. 93.118 Section 93.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... and procedures: Motor vehicle emissions budget. (a) The transportation plan, TIP, and project not from a conforming transportation plan and TIP must be consistent with the motor vehicle emissions budget...

View of Drew in the MDDK of the Shuttle Endeavour during STS-118

NASA Image and Video Library

2007-09-11

S118-E-06828 (11 Aug. 2007) --- Astronaut Alvin Drew, STS-118 mission specialist, works near a hatch of Space Shuttle Endeavour while docked with the International Space Station during flight day four activities. Sleeping bags are visible in the foreground.

37 CFR 1.118-1.119 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false [Reserved] 1.118-1.119 Section 1.118-1.119 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Amendments...

42 CFR 422.118 - Confidentiality and accuracy of enrollee records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Confidentiality and accuracy of enrollee records. 422.118 Section 422.118 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Benefits and Beneficiary...

Atmospheric emission inventory of hazardous trace elements from China's coal-fired power plants--temporal trends and spatial variation characteristics.

PubMed

Tian, Hezhong; Liu, Kaiyun; Zhou, Junrui; Lu, Long; Hao, Jiming; Qiu, Peipei; Gao, Jiajia; Zhu, Chuanyong; Wang, Kun; Hua, Shenbing

2014-03-18

Coal-fired power plants are the important sources of anthropogenic atmospheric releases of various hazardous trace elements (HTE) because a large quantity of emissions can cause wide dispersion and possible long-distance transportation. To obtain the temporal trends and spatial variation characteristics of various HTE discharged from coal-fired power plants of China, a multiple-year comprehensive emission inventory of HTE including Hg, As, Se, Pb, Cd, Cr, Ni, and Sb has been established for the period 2000-2010. Thanks to the cobenefit removal effects of conventional particulate matter/sulfur dioxide/nitrogen oxides (PM/SO2/NOx) control devices, emissions of these 8 toxic elements have shown a gradual decline since the peak in 2006. The total emissions of Hg, As, Se, Pb, Cd, Cr, Ni, and Sb are substantial and are estimated at about 118.54, 335.45, 459.4, 705.45, 13.34, 505.03, 446.42, and 82.33 tons (t), respectively, in 2010. Shandong, Jiangsu, Shanxi, and Hebei always rank among the top ten provinces with the highest emissions. Further, future emissions for 2015 and 2020 are projected with scenario analysis. Advanced technologies and integrated management strategies to control HTE are in great need.

32 CFR 644.118 - Awards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 4 2011-07-01 2011-07-01 false Awards. 644.118 Section 644.118 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK... satisfactory, e.g., the history of past awards at this project or in the same judicial district, the basis used...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

18 CFR 11.8 - Adjustment of annual charges.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Adjustment of annual charges. 11.8 Section 11.8 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... in effect as fixed unless changed as authorized by law. [51 FR 24318, July 3, 1986] ...

42 CFR 460.118 - Violation of rights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Violation of rights. 460.118 Section 460.118 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE...

42 CFR 460.118 - Violation of rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Violation of rights. 460.118 Section 460.118 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE...

41 CFR 102-118.480 - How does my agency settle disputes with a TSP?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How does my agency settle disputes with a TSP? 102-118.480 Section 102-118.480 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION...

7 CFR 15.118 - Cross-examination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Cross-examination. 15.118 Section 15.118 Agriculture Office of the Secretary of Agriculture NONDISCRIMINATION Rules of Practice and Procedure for Hearings...-examination. Cross-examination will be limited to the scope of direct examination and matters at issue in the...

41 CFR 102-118.395 - How long will GSA take to respond to a waiver request?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Waivers from Mandatory Prepayment Audit § 102-118.395 How long will GSA take to respond to a waiver request? GSA will...

41 CFR 102-118.305 - Must my agency notify the TSP of any adjustment to the TSP's bill?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Agency Requirements for Prepayment Audits § 102-118.305 Must my agency notify the TSP of any adjustment...

41 CFR 102-118.420 - Can the Administrator of General Services waive the postpayment auditing provisions of this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

....420 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits § 102-118.420 Can the Administrator of General Services waive the postpayment auditing...

41 CFR 102-118.350 - Does establishing a prepayment audit system or program change the responsibilities of the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... prepayment audit system or program change the responsibilities of the certifying officers? 102-118.350... System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT... Does establishing a prepayment audit system or program change the responsibilities of the certifying...

44 CFR 206.118 - Disposal of housing units.

Code of Federal Regulations, 2012 CFR

2012-10-01

... directly to a State or other governmental entity, or to a voluntary organization, for the sole purpose of... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Disposal of housing units. 206.118 Section 206.118 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY...

44 CFR 206.118 - Disposal of housing units.

Code of Federal Regulations, 2014 CFR

2014-10-01

... directly to a State or other governmental entity, or to a voluntary organization, for the sole purpose of... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Disposal of housing units. 206.118 Section 206.118 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY...

44 CFR 206.118 - Disposal of housing units.

Code of Federal Regulations, 2013 CFR

2013-10-01

... directly to a State or other governmental entity, or to a voluntary organization, for the sole purpose of... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Disposal of housing units. 206.118 Section 206.118 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY...

44 CFR 206.118 - Disposal of housing units.

Code of Federal Regulations, 2011 CFR

2011-10-01

... directly to a State or other governmental entity, or to a voluntary organization, for the sole purpose of... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Disposal of housing units. 206.118 Section 206.118 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY...

24 CFR 972.118 - Applicability of Uniform Relocation Act.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Applicability of Uniform Relocation Act. 972.118 Section 972.118 Housing and Urban Development Regulations Relating to Housing and Urban... URBAN DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Required Conversion of Public...

27 CFR 20.118 - Rubbing alcohol general-use formula.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Rubbing alcohol general-use formula. 20.118 Section 20.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM...

27 CFR 20.118 - Rubbing alcohol general-use formula.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Rubbing alcohol general-use formula. 20.118 Section 20.118 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTRIBUTION AND USE OF DENATURED ALCOHOL AND RUM...

21 CFR 118.7 - Sampling methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Sampling methodology for Salmonella Enteritidis (SE). 118.7 Section 118.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....7 Sampling methodology for Salmonella Enteritidis (SE). (a) Environmental sampling. An environmental...

21 CFR 118.7 - Sampling methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Sampling methodology for Salmonella Enteritidis (SE). 118.7 Section 118.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....7 Sampling methodology for Salmonella Enteritidis (SE). (a) Environmental sampling. An environmental...

21 CFR 118.7 - Sampling methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Sampling methodology for Salmonella Enteritidis (SE). 118.7 Section 118.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....7 Sampling methodology for Salmonella Enteritidis (SE). (a) Environmental sampling. An environmental...

21 CFR 118.5 - Environmental testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Environmental testing for Salmonella Enteritidis (SE). 118.5 Section 118.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....5 Environmental testing for Salmonella Enteritidis (SE). (a) Environmental testing when laying hens...

21 CFR 118.5 - Environmental testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Environmental testing for Salmonella Enteritidis (SE). 118.5 Section 118.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....5 Environmental testing for Salmonella Enteritidis (SE). (a) Environmental testing when laying hens...

21 CFR 118.5 - Environmental testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Environmental testing for Salmonella Enteritidis (SE). 118.5 Section 118.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....5 Environmental testing for Salmonella Enteritidis (SE). (a) Environmental testing when laying hens...

33 CFR 118.120 - Radar reflectors and racons.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Radar reflectors and racons. 118... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.120 Radar reflectors and racons. The District Commander may require or authorize the installation of radar reflectors and racons on bridge structures, stakes...

33 CFR 118.120 - Radar reflectors and racons.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Radar reflectors and racons. 118... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.120 Radar reflectors and racons. The District Commander may require or authorize the installation of radar reflectors and racons on bridge structures, stakes...

41 CFR 102-118.35 - What definitions apply to this part?

Code of Federal Regulations, 2012 CFR

2012-01-01

... between computers instead of paper documents. These electronic transmissions must use established and... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What definitions apply to this part? 102-118.35 Section 102-118.35 Public Contracts and Property Management Federal Property...

41 CFR 102-118.35 - What definitions apply to this part?

Code of Federal Regulations, 2011 CFR

2011-01-01

... between computers instead of paper documents. These electronic transmissions must use established and... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What definitions apply to this part? 102-118.35 Section 102-118.35 Public Contracts and Property Management Federal Property...

41 CFR 102-118.35 - What definitions apply to this part?

Code of Federal Regulations, 2013 CFR

2013-07-01

... between computers instead of paper documents. These electronic transmissions must use established and... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What definitions apply to this part? 102-118.35 Section 102-118.35 Public Contracts and Property Management Federal Property...

41 CFR 102-118.35 - What definitions apply to this part?

Code of Federal Regulations, 2014 CFR

2014-01-01

... between computers instead of paper documents. These electronic transmissions must use established and... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What definitions apply to this part? 102-118.35 Section 102-118.35 Public Contracts and Property Management Federal Property...

32 CFR 552.118 - Issuance from unit arms room.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Issuance from unit arms room. 552.118 Section 552... AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Physical Security of Arms, Ammunition, and Explosives-Fort Lewis, Washington § 552.118 Issuance from unit arms room. When privately...

32 CFR 552.118 - Issuance from unit arms room.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 3 2014-07-01 2014-07-01 false Issuance from unit arms room. 552.118 Section... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Physical Security of Arms, Ammunition, and Explosives-Fort Lewis, Washington § 552.118 Issuance from unit arms room. When privately...

32 CFR 552.118 - Issuance from unit arms room.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true Issuance from unit arms room. 552.118 Section 552... AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Physical Security of Arms, Ammunition, and Explosives-Fort Lewis, Washington § 552.118 Issuance from unit arms room. When privately...

32 CFR 552.118 - Issuance from unit arms room.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 3 2012-07-01 2009-07-01 true Issuance from unit arms room. 552.118 Section 552... AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Physical Security of Arms, Ammunition, and Explosives-Fort Lewis, Washington § 552.118 Issuance from unit arms room. When privately...

32 CFR 552.118 - Issuance from unit arms room.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 3 2013-07-01 2013-07-01 false Issuance from unit arms room. 552.118 Section... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Physical Security of Arms, Ammunition, and Explosives-Fort Lewis, Washington § 552.118 Issuance from unit arms room. When privately...

21 CFR 118.7 - Sampling methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Sampling methodology for Salmonella Enteritidis (SE). 118.7 Section 118.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....7 Sampling methodology for Salmonella Enteritidis (SE). (a) Environmental sampling. An environmental...

21 CFR 118.7 - Sampling methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Sampling methodology for Salmonella Enteritidis (SE). 118.7 Section 118.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....7 Sampling methodology for Salmonella Enteritidis (SE). (a) Environmental sampling. An environmental...

21 CFR 118.5 - Environmental testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Environmental testing for Salmonella Enteritidis (SE). 118.5 Section 118.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....5 Environmental testing for Salmonella Enteritidis (SE). (a) Environmental testing when laying hens...

21 CFR 118.5 - Environmental testing for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Environmental testing for Salmonella Enteritidis (SE). 118.5 Section 118.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN....5 Environmental testing for Salmonella Enteritidis (SE). (a) Environmental testing when laying hens...

33 CFR 118.120 - Radar reflectors and racons.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Radar reflectors and racons. 118... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.120 Radar reflectors and racons. The District Commander may require or authorize the installation of radar reflectors and racons on bridge structures, stakes...

33 CFR 118.120 - Radar reflectors and racons.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Radar reflectors and racons. 118... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.120 Radar reflectors and racons. The District Commander may require or authorize the installation of radar reflectors and racons on bridge structures, stakes...

33 CFR 118.120 - Radar reflectors and racons.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Radar reflectors and racons. 118... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.120 Radar reflectors and racons. The District Commander may require or authorize the installation of radar reflectors and racons on bridge structures, stakes...

42 CFR 136.118 - Effect on existing rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Effect on existing rights. 136.118 Section 136.118 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH Grants for Development, Construction, and Operation of...

37 CFR 1.18 - Patent post allowance (including issue) fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... entity $1,190.00 (d) Publication fee $300.00. (e) For filing an application for patent term adjustment... (including issue) fees. 1.18 Section 1.18 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES General Provisions Fees...

18 CFR 401.118 - Disclosure in administrative or court proceedings.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Disclosure in administrative or court proceedings. 401.118 Section 401.118 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Public Access to Records...

23 CFR 636.118 - Is team switching allowed after contract award?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Is team switching allowed after contract award? 636.118... TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.118 Is team switching allowed after contract...-builder, team member switching (adding or switching team members) is discouraged after contract award...

23 CFR 636.118 - Is team switching allowed after contract award?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Is team switching allowed after contract award? 636.118... TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.118 Is team switching allowed after contract...-builder, team member switching (adding or switching team members) is discouraged after contract award...

23 CFR 636.118 - Is team switching allowed after contract award?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Is team switching allowed after contract award? 636.118... TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.118 Is team switching allowed after contract...-builder, team member switching (adding or switching team members) is discouraged after contract award...

23 CFR 636.118 - Is team switching allowed after contract award?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Is team switching allowed after contract award? 636.118... TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.118 Is team switching allowed after contract...-builder, team member switching (adding or switching team members) is discouraged after contract award...

23 CFR 636.118 - Is team switching allowed after contract award?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Is team switching allowed after contract award? 636.118... TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.118 Is team switching allowed after contract...-builder, team member switching (adding or switching team members) is discouraged after contract award...

21 CFR 118.4 - Salmonella Enteritidis (SE) prevention measures.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Salmonella Enteritidis (SE) prevention measures. 118.4 Section 118.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... equivalent standard; (2) Environmental testing. (i) The pullet environment is tested for SE when pullets are...

21 CFR 118.4 - Salmonella Enteritidis (SE) prevention measures.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Salmonella Enteritidis (SE) prevention measures. 118.4 Section 118.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... equivalent standard; (2) Environmental testing. (i) The pullet environment is tested for SE when pullets are...

21 CFR 118.4 - Salmonella Enteritidis (SE) prevention measures.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Salmonella Enteritidis (SE) prevention measures. 118.4 Section 118.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... equivalent standard; (2) Environmental testing. (i) The pullet environment is tested for SE when pullets are...

21 CFR 118.4 - Salmonella Enteritidis (SE) prevention measures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Salmonella Enteritidis (SE) prevention measures. 118.4 Section 118.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... equivalent standard; (2) Environmental testing. (i) The pullet environment is tested for SE when pullets are...

21 CFR 118.4 - Salmonella Enteritidis (SE) prevention measures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Salmonella Enteritidis (SE) prevention measures. 118.4 Section 118.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... equivalent standard; (2) Environmental testing. (i) The pullet environment is tested for SE when pullets are...

STS118-S-073

NASA Image and Video Library

2007-08-21

STS118-S-073 (21 Aug. 2007) --- NASA Administrator Michael Griffin (center in white shirt) and other NASA managers give thumbs up signals to the crew of the Space Shuttle Endeavour shortly after its touchdown August 21, 2007, at the Kennedy Space Center, Florida, concluding STS-118. Photo Credit: NASA/Bill Ingalls

33 CFR 118.60 - Characteristics of lights.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Characteristics of lights. 118.60... LIGHTING AND OTHER SIGNALS § 118.60 Characteristics of lights. All lights required or authorized under this.... Lights must meet the requirements of this part. Lights shall be fixed lights excepting as provided in...

33 CFR 118.60 - Characteristics of lights.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Characteristics of lights. 118.60... LIGHTING AND OTHER SIGNALS § 118.60 Characteristics of lights. All lights required or authorized under this.... Lights must meet the requirements of this part. Lights shall be fixed lights excepting as provided in...

33 CFR 118.60 - Characteristics of lights.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Characteristics of lights. 118.60... LIGHTING AND OTHER SIGNALS § 118.60 Characteristics of lights. All lights required or authorized under this.... Lights must meet the requirements of this part. Lights shall be fixed lights excepting as provided in...

33 CFR 118.60 - Characteristics of lights.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Characteristics of lights. 118.60... LIGHTING AND OTHER SIGNALS § 118.60 Characteristics of lights. All lights required or authorized under this.... Lights must meet the requirements of this part. Lights shall be fixed lights excepting as provided in...

33 CFR 118.60 - Characteristics of lights.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Characteristics of lights. 118.60... LIGHTING AND OTHER SIGNALS § 118.60 Characteristics of lights. All lights required or authorized under this.... Lights must meet the requirements of this part. Lights shall be fixed lights excepting as provided in...

Stalagmite geochemistry and the timing of the last interglacial-glacial transition in Central Europe (NE Hungary)

NASA Astrophysics Data System (ADS)

Siklosy, Z.; Demeny, A.; Pilet, S.; Leel-Ossy, Sz.; Lin, K.; Shen, C.-C.

2009-04-01

Speleothems can provide accurate chronologies for reconstructions of climate change by combination of U/Th dating and climate-related geochemical compositions. Geochemical studies of speleothems from Central Europe are mostly based on stable C and O isotope analyses, thus, complex geochemical studies combining isotope and trace element measurements are needed for more reliable climate models for this transitional area between oceanic and continental regions. We present stable H-C-O isotope and trace element records obtained on speleothems covering the Last Interglacial (MIS 5e) and the transition to MIS 5d. A stalagmite from Baradla Cave grew from 127.5 to 110 ka. Accelerated growth rates have been detected by U/Th age data in the 127 to 126 ka and 119 to 117 ka parts. Trace element compositions and 230Th/232Th ratios suggest changes in the hydrological regime, whereby early calcite precipitates formed in fissures during the dry and cold glacial period were dissolved by the starting flux of infiltrating meteoric water (producing elevated dissolved ion concentration but low detrital Th component), then the increasing amount of dripwater during the interglacial period resulted in trace element dilution. Temperature and precipitation amount variations are also reflected by the stable isotope compositions. Oxygen isotope composition shows a continuous increase from 127.5 ka until about 118 ka most probably related to temperature rise, whereas C isotope values are shifted in negative direction suggesting increasing humidity in accordance with trace element contents. The presumably warmest period at ca. 118 ka is associated with rather arid climate as indicated by peak d18O values coinciding with the highest dD values of fluid inclusion water. This is followed by a pronounced negative shift in both O and H isotope values, similarly to recent Alpine studies (Meyer et al., 2008), most probably related to cooling. Hydrogen isotope compositions of fluid inclusion water evaluated together with calculated oxygen isotope compositions of water indicate warming and increasing significance of summer precipitation at the latest period of the last interglacial, then increasing importance of winter precipitation and/or changes in oceanic source composition during the cooling phase. The good agreement with other (Alpine and marine) records indicate a synchronous climate change. However, after a negative shift in the wet/warm phase (increasing soil activity), C isotope values start to increase already at about 119 ky BP, warning to the use of the two isotope systems as event correlation tools. In conclusion, our combined isotope and trace element study indicate a complex pattern of temperature and humidity variations during and right after the Last Interglacial. Acknowledgements — This study was financially supported by the Hungarian Scientific Research Fund (OTKA T 049713). Measurements of U-Th isotopic compositions and and 230Th dates were supported by the National Science Council grants (94-2116-M002-012, 97-2752-M002-004-PAE & -005-PAE to C.C.S.). [Meyer, M.; Spötl, C.; Mangini, A. (2008): The demise of the Last Interglacial recorded in isotopically dated speleothems from the Alps. Quaternary Science Reviews, 27, 476-496.

Comparative Genomics and Transcriptional Analysis of Prophages Identified in the Genomes of Lactobacillus gasseri, Lactobacillus salivarius, and Lactobacillus casei†

PubMed Central

Ventura, Marco; Canchaya, Carlos; Bernini, Valentina; Altermann, Eric; Barrangou, Rodolphe; McGrath, Stephen; Claesson, Marcus J.; Li, Yin; Leahy, Sinead; Walker, Carey D.; Zink, Ralf; Neviani, Erasmo; Steele, Jim; Broadbent, Jeff; Klaenhammer, Todd R.; Fitzgerald, Gerald F.; O'Toole, Paul W.; van Sinderen, Douwe

2006-01-01

Lactobacillus gasseri ATCC 33323, Lactobacillus salivarius subsp. salivarius UCC 118, and Lactobacillus casei ATCC 334 contain one (LgaI), four (Sal1, Sal2, Sal3, Sal4), and one (Lca1) distinguishable prophage sequences, respectively. Sequence analysis revealed that LgaI, Lca1, Sal1, and Sal2 prophages belong to the group of Sfi11-like pac site and cos site Siphoviridae, respectively. Phylogenetic investigation of these newly described prophage sequences revealed that they have not followed an evolutionary development similar to that of their bacterial hosts and that they show a high degree of diversity, even within a species. The attachment sites were determined for all these prophage elements; LgaI as well as Sal1 integrates in tRNA genes, while prophage Sal2 integrates in a predicted arginino-succinate lyase-encoding gene. In contrast, Lca1 and the Sal3 and Sal4 prophage remnants are integrated in noncoding regions in the L. casei ATCC 334 and L. salivarius UCC 118 genomes. Northern analysis showed that large parts of the prophage genomes are transcriptionally silent and that transcription is limited to genome segments located near the attachment site. Finally, pulsed-field gel electrophoresis followed by Southern blot hybridization with specific prophage probes indicates that these prophage sequences are narrowly distributed within lactobacilli. PMID:16672450

32 CFR 219.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Applications and proposals lacking definite plans for involvement of human subjects. 219.118 Section 219.118 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219...

25 CFR 900.118 - Do these “construction contract” regulations apply to construction management services?

Code of Federal Regulations, 2014 CFR

2014-04-01

... construction management services? 900.118 Section 900.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE...” regulations apply to construction management services? No. Construction management services may be contracted separately under section 108 of the Act. Construction management services consultants and/or Indian tribe or...

17 CFR 1.18 - Records for and relating to financial reporting and monthly computation by futures commission...

Code of Federal Regulations, 2010 CFR

2010-04-01

... financial reporting and monthly computation by futures commission merchants and introducing brokers. 1.18... UNDER THE COMMODITY EXCHANGE ACT Minimum Financial and Related Reporting Requirements § 1.18 Records for and relating to financial reporting and monthly computation by futures commission merchants and...

21 CFR 118.8 - Testing methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2013 CFR

2013-04-01

...). 118.8 Section 118.8 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, 301-436-2364, or you may examine a copy at the Center for Food Safety and Applied Nutrition's Library, 5100 Paint...

21 CFR 118.8 - Testing methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2011 CFR

2011-04-01

...). 118.8 Section 118.8 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, 301-436-2364, or you may examine a copy at the Center for Food Safety and Applied Nutrition's Library, 5100 Paint...

21 CFR 118.8 - Testing methodology for Salmonella Enteritidis (SE).

Code of Federal Regulations, 2014 CFR

2014-04-01

...). 118.8 Section 118.8 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, 301-436-2364, or you may examine a copy at the Center for Food Safety and Applied Nutrition's Library, 5100 Paint...

46 CFR 171.118 - Automatic ventilators and side ports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Automatic ventilators and side ports. 171.118 Section... SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather Deck § 171.118 Automatic ventilators and side ports. (a) An automatic ventilator must...

46 CFR 171.118 - Automatic ventilators and side ports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Automatic ventilators and side ports. 171.118 Section... SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather Deck § 171.118 Automatic ventilators and side ports. (a) An automatic ventilator must...

46 CFR 171.118 - Automatic ventilators and side ports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Automatic ventilators and side ports. 171.118 Section... SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather Deck § 171.118 Automatic ventilators and side ports. (a) An automatic ventilator must...

46 CFR 171.118 - Automatic ventilators and side ports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Automatic ventilators and side ports. 171.118 Section... SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather Deck § 171.118 Automatic ventilators and side ports. (a) An automatic ventilator must...

46 CFR 171.118 - Automatic ventilators and side ports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Automatic ventilators and side ports. 171.118 Section... SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS Openings in the Side of a Vessel Below the Bulkhead or Weather Deck § 171.118 Automatic ventilators and side ports. (a) An automatic ventilator must...

41 CFR 102-118.520 - Who is responsible for determining the standards for collection, compromise, termination, or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... outstanding debts to my agency? 102-118.520 Section 102-118.520 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who is responsible for...

41 CFR 102-118.450 - Can a TSP file a transportation claim against my agency?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Can a TSP file a transportation claim against my agency? 102-118.450 Section 102-118.450 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION...

33 CFR 100.118 - Searsport Lobster Boat Races, Searsport Harbor, ME.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Searsport Lobster Boat Races, Searsport Harbor, ME. 100.118 Section 100.118 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Lobster Boat Races, Searsport Harbor, ME. (a) Regulated Area. The regulated area includes all waters of...

33 CFR 118.5 - Penalty for failure to maintain.

Code of Federal Regulations, 2010 CFR

2010-07-01

... States who fails or refuses to maintain such lights and other signals, or to obey any of the lawful rules... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Penalty for failure to maintain. 118.5 Section 118.5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY...

75 FR 51880 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

...), Definition of Contribution in Aid of Construction Under Section 118(c)(Sec. 1.118-2). DATES: Written comments should be received on or before October 22, 2010 to be assured of consideration. ADDRESSES: Direct all... . SUPPLEMENTARY INFORMATION: Title: Definition of Contribution in Aid of Construction Under Section 118(c). OMB...

41 CFR 102-118.80 - Who is responsible for keeping my agency's electronic commerce transportation billing records?

Code of Federal Regulations, 2014 CFR

2014-01-01

... electronic transportation billing documents to: General Services Administration Transportation Audit Division... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Who is responsible for keeping my agency's electronic commerce transportation billing records? 102-118.80 Section 102-118.80...

41 CFR 102-118.80 - Who is responsible for keeping my agency's electronic commerce transportation billing records?

Code of Federal Regulations, 2012 CFR

2012-01-01

... electronic transportation billing documents to: General Services Administration Transportation Audit Division... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Who is responsible for keeping my agency's electronic commerce transportation billing records? 102-118.80 Section 102-118.80...

41 CFR 102-118.80 - Who is responsible for keeping my agency's electronic commerce transportation billing records?

Code of Federal Regulations, 2010 CFR

2010-07-01

... electronic transportation billing documents to: General Services Administration Transportation Audit Division... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who is responsible for keeping my agency's electronic commerce transportation billing records? 102-118.80 Section 102-118.80...

41 CFR 102-118.80 - Who is responsible for keeping my agency's electronic commerce transportation billing records?

Code of Federal Regulations, 2013 CFR

2013-07-01

... electronic transportation billing documents to: General Services Administration Transportation Audit Division... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Who is responsible for keeping my agency's electronic commerce transportation billing records? 102-118.80 Section 102-118.80...

41 CFR 102-118.80 - Who is responsible for keeping my agency's electronic commerce transportation billing records?

Code of Federal Regulations, 2011 CFR

2011-01-01

... electronic transportation billing documents to: General Services Administration Transportation Audit Division... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Who is responsible for keeping my agency's electronic commerce transportation billing records? 102-118.80 Section 102-118.80...

46 CFR 118.320 - Fire hoses and nozzles.

Code of Federal Regulations, 2013 CFR

2013-10-01

... commercial fire hose that conforms to Underwriters Laboratory (UL) 19 “Lined Fire Hose and Hose Assemblies... National Fire Protection Association (NFPA) 1963 “Fire Hose Connections,” or other standard specified by... 46 Shipping 4 2013-10-01 2013-10-01 false Fire hoses and nozzles. 118.320 Section 118.320 Shipping...

46 CFR 118.320 - Fire hoses and nozzles.

Code of Federal Regulations, 2011 CFR

2011-10-01

... commercial fire hose that conforms to Underwriters Laboratory (UL) 19 “Lined Fire Hose and Hose Assemblies... National Fire Protection Association (NFPA) 1963 “Fire Hose Connections,” or other standard specified by... 46 Shipping 4 2011-10-01 2011-10-01 false Fire hoses and nozzles. 118.320 Section 118.320 Shipping...

46 CFR 118.320 - Fire hoses and nozzles.

Code of Federal Regulations, 2012 CFR

2012-10-01

... commercial fire hose that conforms to Underwriters Laboratory (UL) 19 “Lined Fire Hose and Hose Assemblies... National Fire Protection Association (NFPA) 1963 “Fire Hose Connections,” or other standard specified by... 46 Shipping 4 2012-10-01 2012-10-01 false Fire hoses and nozzles. 118.320 Section 118.320 Shipping...

46 CFR 118.320 - Fire hoses and nozzles.

Code of Federal Regulations, 2014 CFR

2014-10-01

... commercial fire hose that conforms to Underwriters Laboratory (UL) 19 “Lined Fire Hose and Hose Assemblies... National Fire Protection Association (NFPA) 1963 “Fire Hose Connections,” or other standard specified by... 46 Shipping 4 2014-10-01 2014-10-01 false Fire hoses and nozzles. 118.320 Section 118.320 Shipping...

46 CFR 118.320 - Fire hoses and nozzles.

Code of Federal Regulations, 2010 CFR

2010-10-01

... commercial fire hose that conforms to Underwriters Laboratory (UL) 19 “Lined Fire Hose and Hose Assemblies... National Fire Protection Association (NFPA) 1963 “Fire Hose Connections,” or other standard specified by... 46 Shipping 4 2010-10-01 2010-10-01 false Fire hoses and nozzles. 118.320 Section 118.320 Shipping...

The ITEA-NASA STS-118 Design Challenges

ERIC Educational Resources Information Center

Meade, Shelli D.; Caron, Daniel W.; Gray, Aaron; Weaver, Kim

2008-01-01

In conjunction with the August 8, 2007 launch of STS-118, the International Technology Education Association (ITEA) and National Aeronautics and Space Administration (NASA) developed and recently debuted curricular units for Grades K-12 on Space Exploration, known as STS-118 Design Challenges. The units focus on aspects of the themes that NASA…

21 CFR 118.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Definitions. 118.3 Section 118.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... interpretations of terms in section 201 of the Federal Food, Drug, and Cosmetic Act (the FFDCA) (21 U.S.C. 321...

21 CFR 118.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Definitions. 118.3 Section 118.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... interpretations of terms in section 201 of the Federal Food, Drug, and Cosmetic Act (the FFDCA) (21 U.S.C. 321...

21 CFR 118.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Definitions. 118.3 Section 118.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... interpretations of terms in section 201 of the Federal Food, Drug, and Cosmetic Act (the FFDCA) (21 U.S.C. 321...

21 CFR 118.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Definitions. 118.3 Section 118.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... interpretations of terms in section 201 of the Federal Food, Drug, and Cosmetic Act (the FFDCA) (21 U.S.C. 321...

21 CFR 118.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Definitions. 118.3 Section 118.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... interpretations of terms in section 201 of the Federal Food, Drug, and Cosmetic Act (the FFDCA) (21 U.S.C. 321...

40 CFR 26.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Applications and proposals lacking definite plans for involvement of human subjects. 26.118 Section 26.118 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects...

25 CFR 900.118 - Do these “construction contract” regulations apply to construction management services?

Code of Federal Regulations, 2013 CFR

2013-04-01

... management services, these services shall be limited to: (1) Coordination and exchange of information between... construction management services? 900.118 Section 900.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN...

25 CFR 900.118 - Do these “construction contract” regulations apply to construction management services?

Code of Federal Regulations, 2010 CFR

2010-04-01

... management services, these services shall be limited to: (1) Coordination and exchange of information between... construction management services? 900.118 Section 900.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN...

25 CFR 900.118 - Do these “construction contract” regulations apply to construction management services?

Code of Federal Regulations, 2012 CFR

2012-04-01

... management services, these services shall be limited to: (1) Coordination and exchange of information between... construction management services? 900.118 Section 900.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN...

25 CFR 900.118 - Do these “construction contract” regulations apply to construction management services?

Code of Federal Regulations, 2011 CFR

2011-04-01

... management services, these services shall be limited to: (1) Coordination and exchange of information between... construction management services? 900.118 Section 900.118 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN...

17 CFR 1.18 - Records for and relating to financial reporting and monthly computation by futures commission...

Code of Federal Regulations, 2011 CFR

2011-04-01

... financial reporting and monthly computation by futures commission merchants and introducing brokers. 1.18... UNDER THE COMMODITY EXCHANGE ACT Minimum Financial and Related Reporting Requirements § 1.18 Records for and relating to financial reporting and monthly computation by futures commission merchants and...

Impeding effect of Ce on He bubble growth in bcc Fe

NASA Astrophysics Data System (ADS)

Hao, W.; Geng, W. T.

2012-06-01

Our first-principles density functional theory calculations suggest that the rare earth element Ce has a strong attraction to He (-1.31 eV/atom pair) in bcc Fe, even stronger than He-He attraction (-1.18 eV). The segregated Ce layer at the He bubble surface could introduce an additional energy barrier (0.40 eV) to trespassing He atoms. Therefore, Ce could not only have a pinning effect on mobile He atoms and hence reduce merging rate of He clusters, but also serve as a cover layer to repel further He atoms and thus slows down the bubble growth. The low cost makes Ce a great advantage over Au, which was recently predicted to have similar effect.

Development of a compact permanent magnet helicon plasma source for ion beam bioengineering.

PubMed

Kerdtongmee, P; Srinoum, D; Nisoa, M

2011-10-01

A compact helicon plasma source was developed as a millimeter-sized ion source for ion beam bioengineering. By employing a stacked arrangement of annular-shaped permanent magnets, a uniform axial magnetic flux density up to 2.8 kG was obtained. A cost effective 118 MHz RF generator was built for adjusting forward output power from 0 to 40 W. The load impedance and matching network were then analyzed. A single loop antenna and circuit matching elements were placed on a compact printed circuit board for 50 Ω impedance matching. A plasma density up to 1.1 × 10(12) cm(-3) in the 10 mm diameter tube under the magnetic flux density was achieved with 35 W applied RF power.

Development of a compact permanent magnet helicon plasma source for ion beam bioengineering

NASA Astrophysics Data System (ADS)

Kerdtongmee, P.; Srinoum, D.; Nisoa, M.

2011-10-01

A compact helicon plasma source was developed as a millimeter-sized ion source for ion beam bioengineering. By employing a stacked arrangement of annular-shaped permanent magnets, a uniform axial magnetic flux density up to 2.8 kG was obtained. A cost effective 118 MHz RF generator was built for adjusting forward output power from 0 to 40 W. The load impedance and matching network were then analyzed. A single loop antenna and circuit matching elements were placed on a compact printed circuit board for 50 Ω impedance matching. A plasma density up to 1.1 × 1012 cm-3 in the 10 mm diameter tube under the magnetic flux density was achieved with 35 W applied RF power.

Dispersion-free pulse duration reduction of passively Q-switched microchip lasers.

PubMed

Lehneis, R; Steinmetz, A; Jauregui, C; Limpert, J; Tünnermann, A

2012-11-01

We present a dispersion-free method for the pulse duration reduction of passively Q-switched microchip laser (MCL) seed sources. This technique comprises two stages: one that carries out the self-phase modulation induced spectral broadening in a waveguide structure and a subsequent spectral filtering stage in order to shorten the pulses in time domain. The setup of a proof-of-principle experiment consists of a fiber-amplified passively Q-switched MCL, a passive single-mode fiber used as nonlinear element in which the spectrum is broadened, and a reflective volume-Bragg-grating acting as bandpass filter. A reduction of the pulse duration from 118 to 32 ps with high temporal quality has been achieved with this setup.

The structure of {sup 117}Te and {sup 118}Te and collectivity in {sup 118}Te

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duyar, C.; Draper, J.E.; Rubel, E.C.

1993-10-01

The reactions {sup 82}Se({sup 40}Ar,5n) and {sup 76}Ge({sup 48}Ca, 6 n) (beam energies 180MeV and 190MeV, respectively) were used to populate high spins states of {sup 117}Te and {sup 118}Te, respectively. {gamma} - {gamma} coincidences, E{sub gamma}, and coincidence I{sub gamma} have been measured. Angular correlation/distribution analysis has been made. {sup 117}Te has been extended to spin {approximately} 51/2. Our results do not support the two isolated bands found by Sharma et al. {sup 118}Te has been also extended to spin {approximately}22. A rotational band was found in {sup 118}Te with an average J {approximately}42h{sup 2}/MeV, corresponding to a {Beta}more » {approximately} 0.2.« less

Heavy metal contents in the sediments of astatic ponds: Influence of geomorphology, hydroperiod, water chemistry and vegetation.

PubMed

Gołdyn, Bartłomiej; Chudzińska, Maria; Barałkiewicz, Danuta; Celewicz-Gołdyn, Sofia

2015-08-01

The contents of heavy metals (Cd, Cr, Cu, Ni, Pb, Zn) were analysed in the bottom sediments of 30 small, astatic ponds located in the agricultural landscape of Western Poland. The samples were collected from 118 stations located in patches of four vegetation types. Relationships between the contents of particular elements and four groups of factors (geomorphology, hydroperiod, water quality and vegetation) were tested using Redundancy Analysis (RDA). The most important factors influencing the heavy metal contents were the maximum depth and area of the pond, its hydroperiod, water pH and conductivity values. In general, low quantities of heavy metals were recorded in the sediments of kettle-like ponds (small but located in deep depressions) and high in water bodies of the shore-bursting type (large but shallow). Moreover, quantities of particular elements were influenced by the structure of the vegetation covering the pond. Based on the results, we show which types of astatic ponds are most exposed to contamination and suggest some conservation practices that may reduce the influx of heavy metals. Copyright © 2015 Elsevier Inc. All rights reserved.

Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice.

PubMed

Jouihan, Hani; Will, Sarah; Guionaud, Silvia; Boland, Michelle L; Oldham, Stephanie; Ravn, Peter; Celeste, Anthony; Trevaskis, James L

2017-11-01

Nonalcoholic steatohepatitis (NASH) is an unmet need associated with metabolic syndrome. There are no approved therapies for NASH; however, glucagon-like peptide-1 receptor (GLP-1R) and farnesoid-X receptor (FXR) agonists are promising drug targets. We investigated the therapeutic effects of co-administration of a GLP-1R agonist, IP118, with FXR agonist obeticholic acid (OCA) in mice. OCA and IP118 alone and in combination were sub-chronically administered to Lep ob /Lep ob mice with diet-induced NASH or diet-induced obese (DIO) mice. Metabolic (body weight and glucose) and liver (biochemical and histological) endpoints were assessed. NASH severity in Lep ob /Lep ob mice was graded using a customized integrated scoring system. OCA reduced liver weight and lipid in NASH mice (both by -17%) but had no effect on plasma ALT or AST levels. In contrast, IP118 significantly reduced liver weight (-21%), liver lipid (-15%), ALT (-29%), and AST (-27%). The combination of OCA + IP118 further reduced liver weight (-29%), liver lipid (-22%), ALT (-39%), and AST (-36%). Combination therapy was superior to monotherapies in reducing hepatic steatosis, inflammation, and fibrosis. Hepatic improvements with IP118 and OCA + IP118 were associated with reduced body weight (-4.3% and -3.5% respectively) and improved glycemic control in OCA + IP118-treated mice. In DIO mice, OCA + IP118 co-administration reduced body weight (-25.3%) to a greater degree than IP118 alone (-12.5%) and further improved glucose tolerance and reduced hepatic lipid. Our data suggest a complementary or synergistic therapeutic effect of GLP-1R and FXR agonism in mouse models of metabolic disease and NASH. Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.

[Postoperative complications and survival analysis of 1 118 cases of open splenectomy and azygoportal disconnection in the treatment of portal hypertension].

PubMed

Qi, R Z; Zhao, X; Wang, S Z; Zhang, K; Chang, Z Y; Hu, X L; Wu, M L; Zhang, P R; Yu, L X; Xiao, C H; Shi, X J; Li, Z W

2018-06-01

Objective: To analyze the recent postoperative and long-term postoperative complications of open-splenectomy and disconnection in patients with portal hypertension. Methods: There were 1 118 cases with portal hypertension who underwent open splenectomy and azygoportal disconnection from April 2010 to September 2015 at Department of Surgery, People's Liberation Army 302 Hospital. Retrospective case investigation and telephone follow-up were conducted in October 2016. All patients had history of upper gastrointestinal bleeding before operation. Short-term complications after surgery were recorded including secondary laparotomy of postoperative abdominal hemostasis, severe infection, intake disorders, liver insufficiency, postoperative portal vein thrombosis and perioperative mortality. Long-term data including postoperative upper gastrointestinal rebleeding, postoperative survival rate and incidence of postoperative malignancy were recorded, too. GraphPad Prism 5 software for data survival analysis and charting. Results: Postoperative short-term complications in 1 118 patients included secondary laparotomy of postoperative abdominal hemostasis(1.8%, 21/1 118), severe infection(2.9%, 32/1 118), intake disorders(1.0%, 11/1 118), liver dysfunction (1.6%, 18/1 118), postoperative portal vein thrombosis(47.1%, 526/1 118)and perioperative mortality(0.5%, 5/1 118). After phone call following-up, 942 patients' long-term data were completed including 1, 3, 5 years postoperative upper gastrointestinal rebleeding rate(4.4%, 12.1%, 17.2%), 1, 3, 5-year postoperative survival rate(97.0%, 93.5%, 90.3%); the incidence of postoperative malignant tumors in 1, 3 and 5 years were 1.7%, 4.4% and 6.2%. Conclusions: Reasonable choosing of surgical indications and timing, proper performing the surgery process, effective conducting perioperative management of portal hypertension are directly related to the patient's short-term prognosis after portal hypertension. Surgical intervention can reduce the rates of patients with upper gastrointestinal rebleeding, improve survival, and do not increase the incidence of malignant tumors.

AmyI-1-18, a cationic α-helical antimicrobial octadecapeptide derived from α-amylase in rice, inhibits the translation and folding processes in a protein synthesis system.

PubMed

Taniguchi, Masayuki; Ochiai, Akihito; Fukuda, Shun; Sato, Teppei; Saitoh, Eiichi; Kato, Tetsuo; Tanaka, Takaaki

2016-10-01

In our previous study, we used a cell-free rapid translation system (RTS), which is an in vitro protein synthesis system based on Escherichia coli lysate, for evaluating the inhibition of green fluorescent protein (GFP) synthesis by pyrrhocoricin. In this study, using an RTS, we evaluated the inhibition of GFP synthesis by AmyI-1-18, an antimicrobial octadecapeptide. We found that, similarly to pyrrhocoricin, AmyI-1-18 inhibited GFP synthesis in the RTS in a concentration-dependent manner. In addition, the blockage of transcription and translation steps in the RTS was individually estimated using RT-PCR after gene expression to determine the mRNA products and using sodium dodecyl sulfate-polyacrylamide gel electrophoresis to determine the amounts of GFP expressed from purified mRNA, respectively. The results demonstrated that the inhibition of GFP synthesis by AmyI-1-18 did not occur at the transcription step but rather at the translation step. Furthermore, we assessed the inhibition of DnaK-mediated refolding of chemically denatured luciferase by AmyI-1-18; AmyI-1-18 inhibited the protein folding activity of the ATP-dependent DnaK/DnaJ molecular chaperone system in a concentration-dependent manner. Surface plasmon resonance (SPR) analysis showed that AmyI-1-18 strongly bound to RNA with a KD value of 1.4 × 10(-8) M but not to DNA and that AmyI-1-18 specifically bound to DnaK with a KD value of 4.4 × 10(-6) M. These SPR analysis results supported the results obtained in both the RTS and the molecular chaperone system. These results demonstrated that both RNA and DnaK are most likely the target of AmyI-1-18 in the protein synthesis system. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Characterisation of a novel integrative and conjugative element ICESsD9 carrying erm(B) and tet(O) resistance determinants in Streptococcus suis, and the distribution of ICESsD9-like elements in clinical isolates.

PubMed

Huang, Kaisong; Song, Yajing; Zhang, Qiang; Zhang, Anding; Jin, Meilin

2016-12-01

This study identified a novel integrative and conjugative element (ICESsD9) carrying erm(B) and tet(O) resistance determinants in Streptococcus suis D9 and determined its prevalence in clinical isolates. Comparative genome analysis was performed using Mauve and Artemis Comparison Tool visualisation programs. Inverse PCR was utilised to detect its circular intermediate. The transfer capacity of ICESsD9 was evaluated by mating assays using S. suis A7 and Enterococcus faecalis JH2-2 as recipients. A genome walking approach was employed to analyse the characteristics of integration sites in transconjugants. A total of 118 clinical S. suis isolates were tested by PCR mapping assays to detect ICESsD9-like elements. MLST was performed on isolates containing ICESsD9 variants to determine their clonal relatedness. This 55 683-bp element can actively excise from the chromosome. Additionally, it was capable of transferring both into S. suis and E. faecalis with frequencies of 1.2×10 -4 and 5.8×10 -6 per donor, respectively. When investigating integration site features, it was found that ICESsD9 can enter S. suis and E. faecalis chromosomes by different sites, generating 15-bp and 3-bp direct repeat sequences, respectively. Twelve isolates mainly belonging to sequence types ST1, ST7 and ST28 were confirmed to harbour ICESsD9-like elements. In conclusion, this study provides the first description of an ICE in S. suis that is capable of transferring both into S. suis and E. faecalis. The presence of different ICESsD9 variants in clinical isolates suggests already wide dissemination of this family element in S. suis in China. Copyright © 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

32 CFR 536.118 - Related statutes for maritime claims.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Related statutes for maritime claims. 536.118... ACCOUNTS CLAIMS AGAINST THE UNITED STATES Maritime Claims § 536.118 Related statutes for maritime claims... under the AMCSA is not mandatory for causes of action as it is for the SIAA or PVA. (b) Similar maritime...

41 CFR 102-118.470 - Are there statutory time limits for a TSP on filing an administrative claim with the GSA Audit...

Code of Federal Regulations, 2010 CFR

2010-07-01

...-118.470 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Claims and... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Are there statutory time...

40 CFR 51.118 - Stack height provisions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... exceeds good engineering practice or by any other dispersion technique, except as provided in § 51.118(b... based on a good engineering practice stack height that exceeds the height allowed by § 51.100(ii) (1) or... actual stack height of any source. (b) The provisions of § 51.118(a) shall not apply to (1) stack heights...

34 CFR 75.118 - Requirements for a continuation award.

Code of Federal Regulations, 2014 CFR

2014-07-01

... number 1875-0102) (Authority: 20 U.S.C. 1221e-3(a)(1) and 3474) Cross Reference: See § 75.117 Information... 34 Education 1 2014-07-01 2014-07-01 false Requirements for a continuation award. 75.118 Section 75.118 Education Office of the Secretary, Department of Education DIRECT GRANT PROGRAMS How To Apply...

33 CFR 118.70 - Lights on swing bridges.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lights on swing bridges. 118.70... LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges. Each... an approaching vessel the swing span when closed will display three red lights on top of the span...

33 CFR 118.65 - Lights on fixed bridges.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lights on fixed bridges. 118.65... LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable... range of two green lights, and each margin of each navigable channel will be marked by a red light...

33 CFR 118.65 - Lights on fixed bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights on fixed bridges. 118.65... LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable... range of two green lights, and each margin of each navigable channel will be marked by a red light...

33 CFR 118.70 - Lights on swing bridges.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lights on swing bridges. 118.70... LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges. Each... an approaching vessel the swing span when closed will display three red lights on top of the span...

33 CFR 118.65 - Lights on fixed bridges.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lights on fixed bridges. 118.65... LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable... range of two green lights, and each margin of each navigable channel will be marked by a red light...

33 CFR 118.70 - Lights on swing bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights on swing bridges. 118.70... LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges. Each... an approaching vessel the swing span when closed will display three red lights on top of the span...

33 CFR 118.65 - Lights on fixed bridges.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lights on fixed bridges. 118.65... LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable... range of two green lights, and each margin of each navigable channel will be marked by a red light...

33 CFR 118.70 - Lights on swing bridges.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lights on swing bridges. 118.70... LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges. Each... an approaching vessel the swing span when closed will display three red lights on top of the span...

Antimicrobial activity and mechanism of action of a novel cationic α-helical octadecapeptide derived from α-amylase of rice.

PubMed

Taniguchi, Masayuki; Ochiai, Akihito; Takahashi, Kiyoshi; Nakamichi, Shun-ichi; Nomoto, Takafumi; Saitoh, Eiichi; Kato, Tetsuo; Tanaka, Takaaki

2015-03-01

AmyI-1-18, an octadecapeptide derived from α-amylase (AmyI-1) of rice (Oryza sativa L. japonica), is a novel cationic α-helical antimicrobial peptide (AMP) that contains two lysine and two arginine residues. The antimicrobial activity of AmyI-1-18 against human pathogens was quantitatively evaluated using a chemiluminescence method that measures ATP derived from viable cells. Of the ten kinds of human pathogens, AmyI-1-18 exhibited antimicrobial activity against nine. Its 50% growth-inhibitory concentrations (ICs50 ) against Porphyromonas gingivalis, Propionibacterium acnes, Pseudomonas aeruginosa, Candida albicans, and Streptococcus mutans were 13, 19, 50, 64, and 77 μM, respectively. AmyI-1-18 had little or no hemolytic activity even at 500 μM, and showed negligible cytotoxicity up to 1200 μM. The degree of 3,3'-dipropylthiadicarbocyanine iodide release from P. gingivalis cells induced by the addition of AmyI-1-18 was significantly lower than that induced by the addition of melittin. Flow cytometric analysis showed that the percentages of P. aeruginosa, S. mutans, and C. albicans cells stained with propidium iodide (PI), a DNA-intercalating dye, were 89%, 43%, and 3%, respectively, when AmyI-1-18 was added at a concentration equal to its 4×IC50 . Therefore, the antimicrobial activity of AmyI-1-18 against P. aeruginosa and S. mutans appears to be mainly attributable to its membrane-disrupting activity. In contrast, its antimicrobial activity against P. gingivalis and C. albicans most likely depends upon interactions with intracellular targets other than their cell membranes. Collectively, these results indicate that AmyI-1-18 is useful as a safe and potent AMP against the pathogens described above in many fields of healthcare. © 2015 Wiley Periodicals, Inc.

Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin.

PubMed

Feltus, F A; Groner, B; Melner, M H

1999-07-01

Altered PRL levels are associated with infertility in women. Molecular targets at which PRL elicits these effects have yet to be determined. These studies demonstrate transcriptional regulation by PRL of the gene encoding the final enzymatic step in progesterone biosynthesis: 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase (3beta-HSD). A 9/9 match with the consensus Stat5 response element was identified at -110 to -118 in the human Type II 3beta-HSD promoter. 3beta-HSD chloramphenicol acetyltransferase (CAT) reporter constructs containing either an intact or mutated Stat5 element were tested for PRL activation. Expression vectors for Stat5 and the PRL receptor were cotransfected with a -300 --> +45 3beta-HSD CAT reporter construct into HeLa cells, which resulted in a 21-fold increase in reporter activity in the presence of PRL. Promoter activity showed an increased response with a stepwise elevation of transfected Stat5 expression or by treatment with increasing concentrations of PRL (max, 250 ng/ml). This effect was dramatically reduced when the putative Stat5 response element was removed by 5'-deletion of the promoter or by the introduction of a 3-bp mutation into critical nucleotides in the element. Furthermore, 32P-labeled promoter fragments containing the Stat5 element were shifted in electrophoretic mobility shift assay experiments using nuclear extracts from cells treated with PRL, and this complex was supershifted with antibodies to Stat5. These results demonstrate that PRL has the ability to regulate expression of a key human enzyme gene (type II 3beta-HSD) in the progesterone biosynthetic pathway, which is essential for maintaining pregnancy.

Chemical composition of selected seaweeds from the Indian Ocean, KwaZulu-Natal coast, South Africa.

PubMed

Magura, Judie; Moodley, Roshila; Jonnalagadda, Sreekantha B

2016-08-02

The chemical composition of three edible seaweeds (Codium capitatum, Hypnea spicifera and Sargassum elegans) and two inedible seaweeds (Halimeda cuneata and Spyridia hypnoides) from the Indian Ocean along the KwaZulu-Natal East Coast, South Africa were investigated as a function of seasonal variation. The proximate compositions of the edible seaweeds were determined. In edible seaweeds, the moisture level ranged from 85.4 to 89.5%, protein from 6.1 to 11.8%, lipids from 7.5 to 13.1% and carbohydrates from 37.8 to 71.9%. Elemental concentrations in the five studied seaweeds varied significantly with season (P < 0.05) with mean elemental concentrations (in µg g(-1), dry weight) being: Ca (29 260), Mg (6 279), Fe (1 086), Cu (145.9), Mn (48.32), As (24.29), Zn (15.65), Ni (9.83), Cr (5.78), Pb (4.84), Co (0.87) and Se (0.86). The concentrations of As were particularly high in S. elegans, ranging from 94.70 ± 6.6 µg g(-1) in winter to 65.10 ± 2.3 µg g(-1) in summer. Hierarchical cluster analysis showed similar distribution of elements in edible seaweeds which was dissimilar to that in inedible seaweeds. This study suggests that edible macro alga, C. capitatum and H. spicifera, could be potential sources of most essential nutrients and may contribute positively to the diet without posing the risk of adverse health effects due to low concentrations of toxic elements. However, due to high levels of As in S. elegans, its consumption should be moderated to reduce dietary exposure to this toxic element.

41 CFR 102-118.550 - How does a TSP file an administrative claim using EDI or other electronic means?

Code of Federal Regulations, 2010 CFR

2010-07-01

... administrative claim using EDI or other electronic means? 102-118.550 Section 102-118.550 Public Contracts and... EDI or other electronic means? The medium and precise format of data for an administrative claim filed electronically must be approved in advance by the GSA Audit Division. GSA will use an authenticating EDI...

21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Registration requirements for shell egg producers..., STORAGE, AND TRANSPORTATION OF SHELL EGGS § 118.11 Registration requirements for shell egg producers covered by the requirements of this part. (a) Shell egg producers covered under § 118.1(a) of this part...

42 CFR 435.118 - Infants and children under age 19.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 4 2014-10-01 2014-10-01 false Infants and children under age 19. 435.118 Section..., Children Under 19, and Newborn Children § 435.118 Infants and children under age 19. (a) Basis. This...); and 1931(b) and (d) of the Act. (b) Scope. The agency must provide Medicaid to children under age 19...

42 CFR 435.118 - Infants and children under age 19.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 4 2013-10-01 2013-10-01 false Infants and children under age 19. 435.118 Section..., Children Under 19, and Newborn Children § 435.118 Infants and children under age 19. (a) Basis. This...); and 1931(b) and (d) of the Act. (b) Scope. The agency must provide Medicaid to children under age 19...

STS-118 Ascent/Entry Flight Control Team in White Flight Control Room (WFCR) with Flight Director Steve Stitch

NASA Image and Video Library

2007-07-20

JSC2007-E-41011 (20 July 2007) --- STS-118 Ascent/Entry flight control team pose for a group portrait in the space shuttle flight control room of Houston's Mission Control Center (MCC). Flight director Steve Stich (center right) and astronaut Tony Antonelli, spacecraft communicator (CAPCOM), hold the STS-118 mission logo.

Cleanup Verification Package for the 118-F-5 PNL Sawdust Pit

DOE Office of Scientific and Technical Information (OSTI.GOV)

L. D. Habel

2008-05-20

This cleanup verification package documents completion of remedial action, sampling activities, and compliance with cleanup criteria for the 118-F-5 Burial Ground, the PNL (Pacific Northwest Laboratory) Sawdust Pit. The 118-F-5 Burial Ground was an unlined trench that received radioactive sawdust from the floors of animal pens in the 100-F Experimental Animal Farm.

21 CFR 118.11 - Registration requirements for shell egg producers covered by the requirements of this part.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Registration requirements for shell egg producers..., STORAGE, AND TRANSPORTATION OF SHELL EGGS § 118.11 Registration requirements for shell egg producers covered by the requirements of this part. (a) Shell egg producers covered under § 118.1(a) are required to...

33 CFR 118.80 - Lights on bascule bridges.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lights on bascule bridges. 118.80... LIGHTING AND OTHER SIGNALS § 118.80 Lights on bascule bridges. (a) Lift span lights. Each lift span of... green light which shows only when the span is fully open for the passage of a vessel and by a red light...

33 CFR 118.80 - Lights on bascule bridges.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lights on bascule bridges. 118.80... LIGHTING AND OTHER SIGNALS § 118.80 Lights on bascule bridges. (a) Lift span lights. Each lift span of... green light which shows only when the span is fully open for the passage of a vessel and by a red light...

33 CFR 118.80 - Lights on bascule bridges.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lights on bascule bridges. 118.80... LIGHTING AND OTHER SIGNALS § 118.80 Lights on bascule bridges. (a) Lift span lights. Each lift span of... green light which shows only when the span is fully open for the passage of a vessel and by a red light...

View of Crewmembers in the SM during STS-118/Expedition 15 Joint Operations

NASA Image and Video Library

2007-08-18

S118-E-09261 (18 Aug. 2007) --- Astronaut Barbara R. Morgan, STS-118 mission specialist, uses a video camera during a farewell ceremony in the Zvezda Service Module of the International Space Station. Astronaut Tracy Caldwell, mission specialist, is visible at right. Hatches were closed between the station and Space Shuttle Endeavour at 4:10 p.m. on Aug. 18.

An Extended IEEE 118-Bus Test System With High Renewable Penetration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pena, Ivonne; Martinez-Anido, Carlo Brancucci; Hodge, Bri-Mathias

This article describes a new publicly available version of the IEEE 118-bus test system, named NREL-118. The database is based on the transmission representation (buses and lines) of the IEEE 118-bus test system, with a reconfigured generation representation using three regions of the US Western Interconnection from the latest Western Electricity Coordination Council (WECC) 2024 Common Case [1]. Time-synchronous hourly load, wind, and solar time series are provided for over one year (8784 hours). The public database presented and described in this manuscript will allow researchers to model a test power system using detailed transmission, generation, load, wind, and solarmore » data. This database includes key additional features that add to the current IEEE 118-bus test model, such as: the inclusion of 10 generation technologies with different heat rate functions, minimum stable levels and ramping rates, GHG emissions rates, regulation and contingency reserves, and hourly time series data for one full year for load, wind and solar generation.« less

View of STS-118 MS Morgan in the SPACEHAB

NASA Image and Video Library

2007-08-17

S118-E-07765 (17 Aug. 2007) --- Astronaut Barbara R. Morgan, mission specialist, finds herself surrounded by supplies in SPACEHAB, located in the cargo bay of the Space Shuttle Endeavour. Supply transfer was one of the main activities on the agenda Aug. 17 for the STS-118 crewmembers, who learned their anticipated departure from the International Space Station will come a day earlier due to possible weather issues back home.

Hubble Space Telescope Imaging of the Active Dwarf Galaxy RGG 118

NASA Astrophysics Data System (ADS)

Baldassare, Vivienne F.; Reines, Amy E.; Gallo, Elena; Greene, Jenny E.

2017-12-01

RGG 118 (SDSS 1523+1145) is a nearby (z = 0.0243), dwarf disk galaxy ({M}* ≈ 2× {10}9 {M}⊙ ) that is found to host an active ˜50,000 solar mass black hole at its core. RGG 118 is one of a growing collective sample of dwarf galaxies known to contain active galactic nuclei (AGNs)—a group that, until recently, contained only a handful of objects. Here, we report on new Hubble Space Telescope Wide Field Camera 3 UVIS and IR imaging of RGG 118, with the main goal of analyzing its structure. Using 2D parametric modeling, we find that the morphology of RGG 118 is best described by an outer spiral disk, an inner component consistent with a pseudobulge, and a central point-spread function (PSF). The luminosity of the PSF is consistent with the central point source that is being dominated by the AGN. We measure the luminosity and the mass of the “pseudobulge” and confirm that the central black hole in RGG 118 is under-massive, with respect to the {M}{BH}{--}{M}{bulge} and {M}{BH}{--}{L}{bulge} relations. This result is consistent with a picture in which black holes in disk-dominated galaxies grow primarily through secular processes.

Receptor binding proteins of Listeria monocytogenes bacteriophages A118 and P35 recognize serovar-specific teichoic acids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bielmann, Regula; Habann, Matthias; Eugster, Marcel R.

Adsorption of a bacteriophage to the host requires recognition of a cell wall-associated receptor by a receptor binding protein (RBP). This recognition is specific, and high affinity binding is essential for efficient virus attachment. The molecular details of phage adsorption to the Gram-positive cell are poorly understood. We present the first description of receptor binding proteins and a tail tip structure for the siphovirus group infecting Listeria monocytogenes. The host-range determining factors in two phages, A118 and P35 specific for L. monocytogenes serovar 1/2 have been determined. Two proteins were identified as RBPs in phage A118. Rhamnose residues in wallmore » teichoic acids represent the binding ligands for both proteins. In phage P35, protein gp16 could be identified as RBP and the role of both rhamnose and N-acetylglucosamine in phage adsorption was confirmed. Immunogold-labeling and transmission electron microscopy allowed the creation of a topological model of the A118 phage tail. - Highlights: • We present the first description of receptor binding proteins and a tail tip structure for the Siphovirus group infecting Listeria monocytogenes. • The host-range determining factors in two phages, A118 and P35 specific for L. monocytogenes serovar 1/2 have been determined. • Rhamnose residues in wall teichoic acids represent the binding ligands for both receptor binding proteins in phage A118. • Rhamnose and N-acetylglucosamine are required for adsorption of phage P35. • We preset a topological model of the A118 phage tail.« less

Efficacy of PLD-118, a Novel Inhibitor of Candida Isoleucyl-tRNA Synthetase, against Experimental Oropharyngeal and Esophageal Candidiasis Caused by Fluconazole-Resistant C. albicans

PubMed Central

Petraitis, Vidmantas; Petraitiene, Ruta; Kelaher, Amy M.; Sarafandi, Alia A.; Sein, Tin; Mickiene, Diana; Bacher, John; Groll, Andreas H.; Walsh, Thomas J.

2004-01-01

PLD-118, formerly BAY 10-8888, is a synthetic antifungal derivative of the naturally occurring β-amino acid cispentacin. We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albicans in immunocompromised rabbits. Infection was established by fluconazole-resistant (MIC > 64 μg/ml) clinical isolates from patients with refractory esophageal candidiasis. Antifungal therapy was administered for 7 days. Study groups consisted of untreated controls; animals receiving PLD-118 at 4, 10, 25, or 50 mg/kg of body weight/day via intravenous (i.v.) twice daily (BID) injections; animals receiving FLC at 2 mg/kg/day via i.v. BID injections; and animals receiving desoxycholate amphotericin B (DAMB) i.v. at 0.5 mg/kg/day. PLD-118- and DAMB-treated animals showed a significant dosage-dependent clearance of C. albicans from the tongue, oropharynx, and esophagus in comparison to untreated controls (P ≤ 0.05, P ≤ 0.01, P ≤ 0.001, respectively), while FLC had no significant activity. PLD-118 demonstrated nonlinear plasma pharmacokinetics across the investigated dosage range, as was evident from a dose-dependent increase in plasma clearance and a dose-dependent decrease in the area under the plasma concentration-time curve. The biochemical safety profile was similar to that of FLC. In summary, PLD-118 demonstrated dosage-dependent antifungal activity and nonlinear plasma pharmacokinetics in treatment of experimental FLC-resistant oropharyngeal and esophageal candidiasis. PMID:15388459

Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.

PubMed

Petraitis, Vidmantas; Petraitiene, Ruta; Kelaher, Amy M; Sarafandi, Alia A; Sein, Tin; Mickiene, Diana; Bacher, John; Groll, Andreas H; Walsh, Thomas J

2004-10-01

PLD-118, formerly BAY 10-8888, is a synthetic antifungal derivative of the naturally occurring beta-amino acid cispentacin. We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albicans in immunocompromised rabbits. Infection was established by fluconazole-resistant (MIC > 64 microg/ml) clinical isolates from patients with refractory esophageal candidiasis. Antifungal therapy was administered for 7 days. Study groups consisted of untreated controls; animals receiving PLD-118 at 4, 10, 25, or 50 mg/kg of body weight/day via intravenous (i.v.) twice daily (BID) injections; animals receiving FLC at 2 mg/kg/day via i.v. BID injections; and animals receiving desoxycholate amphotericin B (DAMB) i.v. at 0.5 mg/kg/day. PLD-118- and DAMB-treated animals showed a significant dosage-dependent clearance of C. albicans from the tongue, oropharynx, and esophagus in comparison to untreated controls (P

E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue.

PubMed

Lim, Jung Hwa; Shin, Hee Won; Chung, Kyung-Sook; Kim, Nam-Soon; Kim, Ju Hee; Jung, Hong-Ryul; Im, Dong-Soo; Jung, Cho-Rok

Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo. The initiation of the ubiquitin reaction depended on not only Lys11 linkage but also the Lys6, Lys48 and Lys63 residues of ubiquitin, which were involved in polyubiquitin chain formation on UCP itself. UCP self-association occurred through the UBC domain, which also contributed to the interaction with pVHL. The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination. The Lys76 residue of UCP was the most critical site for auto-ubiquitination, whereas the polyubiquitin chain formation on pVHL occurred on all three of its lysines (Lys159, Lys171 and Lys196). A UCP mutant in which Cys118 was changed to alanine (UCPC118A) did not form a polyubiquitin chain but did strongly accumulate mono- and di-ubiquitin via auto-ubiquitination. Polyubiquitin chain formation required the coordination of Cys95 and Cys118 between two interacting molecules. The mechanism of the polyubiquitin chain reaction of UCP may involve the transfer of ubiquitin from Cys95 to Cys118 by trans-thiolation, with polyubiquitin chains forming at Cys118 by reversible thioester bonding. The polyubiquitin chains are then moved to the lysine residues of the substrate by irreversible isopeptide bonding. During the elongation of the ubiquitin chain, an active Cys118 residue is required in both parts of UCP, namely, the catalytic enzyme and the substrate. In conclusion, UCP possesses not only E2 ubiquitin conjugating enzyme activity but also E3 ubiquitin ligase activity, and Cys118 is critical for polyubiquitin chain formation.

E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue

PubMed Central

Lim, Jung Hwa; Shin, Hee Won; Chung, Kyung-Sook; Kim, Nam-Soon; Kim, Ju Hee; Jung, Hong-Ryul; Im, Dong-Soo; Jung, Cho-Rok

2016-01-01

Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo. The initiation of the ubiquitin reaction depended on not only Lys11 linkage but also the Lys6, Lys48 and Lys63 residues of ubiquitin, which were involved in polyubiquitin chain formation on UCP itself. UCP self-association occurred through the UBC domain, which also contributed to the interaction with pVHL. The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination. The Lys76 residue of UCP was the most critical site for auto-ubiquitination, whereas the polyubiquitin chain formation on pVHL occurred on all three of its lysines (Lys159, Lys171 and Lys196). A UCP mutant in which Cys118 was changed to alanine (UCPC118A) did not form a polyubiquitin chain but did strongly accumulate mono- and di-ubiquitin via auto-ubiquitination. Polyubiquitin chain formation required the coordination of Cys95 and Cys118 between two interacting molecules. The mechanism of the polyubiquitin chain reaction of UCP may involve the transfer of ubiquitin from Cys95 to Cys118 by trans-thiolation, with polyubiquitin chains forming at Cys118 by reversible thioester bonding. The polyubiquitin chains are then moved to the lysine residues of the substrate by irreversible isopeptide bonding. During the elongation of the ubiquitin chain, an active Cys118 residue is required in both parts of UCP, namely, the catalytic enzyme and the substrate. In conclusion, UCP possesses not only E2 ubiquitin conjugating enzyme activity but also E3 ubiquitin ligase activity, and Cys118 is critical for polyubiquitin chain formation. PMID:27685940

Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model

PubMed Central

Aikawa, Tomonori; Mogushi, Kaoru; Iijima-Tsutsui, Kumiko; Ishikawa, Kinya; Sakurai, Miyano; Tanaka, Hiroshi; Mizusawa, Hidehiro; Watase, Kei

2015-01-01

Spinocerebellar ataxia type 6 (SCA6) is dominantly inherited neurodegenerative disease, caused by an expansion of CAG repeat encoding a polyglutamine (PolyQ) tract in the Cav2.1 voltage-gated calcium channel. Its key pathological features include selective degeneration of the cerebellar Purkinje cells (PCs), a common target for PolyQ-induced toxicity in various SCAs. Mutant Cav2.1 confers toxicity primarily through a toxic gain-of-function mechanism; however, its molecular basis remains elusive. Here, we studied the cerebellar gene expression patterns of young Sca6-MPI118Q/118Q knockin (KI) mice, which expressed mutant Cav2.1 from an endogenous locus and recapitulated many phenotypic features of human SCA6. Transcriptional signatures in the MPI118Q/118Q mice were distinct from those in the Sca1154Q/2Q mice, a faithful SCA1 KI mouse model. Temporal expression profiles of the candidate genes revealed that the up-regulation of genes associated with microglial activation was initiated before PC degeneration and was augmented as the disease progressed. Histological analysis of the MPI118Q/118Q cerebellum showed the predominance of M1-like pro-inflammatory microglia and it was concomitant with elevated expression levels of tumor necrosis factor, interleukin-6, Toll-like receptor (TLR) 2 and 7. Genetic ablation of MyD88, a major adaptor protein conveying TLR signaling, altered expression patterns of M1/M2 microglial phenotypic markers in the MPI118Q/118Q cerebellum. More importantly, it ameliorated PC loss and partially rescued motor impairments in the early disease phase. These results suggest that early neuroinflammatory response may play an important role in the pathogenesis of SCA6 and its modulation could pave the way for slowing the disease progression during the early stage of the disease. PMID:26034136

The 253-kb inversion and deep intronic mutations in UNC13D are present in North American patients with familial hemophagocytic lymphohistiocytosis 3.

PubMed

Qian, Yaping; Johnson, Judith A; Connor, Jessica A; Valencia, C Alexander; Barasa, Nathaniel; Schubert, Jeffery; Husami, Ammar; Kissell, Diane; Zhang, Ge; Weirauch, Matthew T; Filipovich, Alexandra H; Zhang, Kejian

2014-06-01

The mutations in UNC13D are responsible for familial hemophagocytic lymphohistiocytosis (FHL) type 3. A 253-kb inversion and two deep intronic mutations, c.118-308C > T and c.118-307G > A, in UNC13D were recently reported in European and Asian FHL3 patients. We sought to determine the prevalence of these three non-coding mutations in North American FHL patients and evaluate the significance of examining these new mutations in genetic testing. We performed DNA sequencing of UNC13D and targeted analysis of these three mutations in 1,709 North American patients with a suspected clinical diagnosis of hemophagocytic lymphohistiocytosis (HLH). The 253-kb inversion, intronic mutations c.118-308C > T and c.118-307G > A were found in 11, 15, and 4 patients, respectively, in which the genetic basis (bi-allelic mutations) explained 25 additional patients. Taken together with previously diagnosed FHL3 patients in our HLH patient registry, these three non-coding mutations were found in 31.6% (25/79) of the FHL3 patients. The 253-kb inversion, c.118-308C > T and c.118-307G > A accounted for 7.0%, 8.9%, and 1.3% of mutant alleles, respectively. Significantly, eight novel mutations in UNC13D are being reported in this study. To further evaluate the expression level of the newly reported intronic mutation c.118-307G > A, reverse transcription PCR and Western blot analysis revealed a significant reduction of both RNA and protein levels suggesting that the c.118-307G > A mutation affects transcription. These specified non-coding mutations were found in a significant number of North American patients and inclusion of them in mutation analysis will improve the molecular diagnosis of FHL3. © 2014 Wiley Periodicals, Inc.

7 CFR 1220.118 - Person.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.118 Person. The term person...

7 CFR 1220.118 - Person.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.118 Person. The term person...

Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence.

PubMed

Welling, Roberta; Beaumont, James J; Petersen, Scott J; Alexeeff, George V; Steinmaus, Craig

2015-02-01

Chromium VI (hexavalent chromium, Cr(VI)) is an established cause of lung cancer, but its association with gastrointestinal cancer is less clear. The goal of this study was to examine whether the current human epidemiological research on occupationally inhaled Cr(VI) supports the hypothesis that Cr(VI) is associated with human stomach cancer. Following a thorough literature search and review of individual studies, we used meta-analysis to summarise the current epidemiological literature on inhaled Cr(VI) and stomach cancer, explore major sources of heterogeneity, and assess other elements of causal inference. We identified 56 cohort and case-control studies and 74 individual relative risk (RR) estimates on stomach cancer and Cr(VI) exposure or work in an occupation associated with high Cr(VI) exposure including chromium production, chrome plating, leather work and work with Portland cement. The summary RR for all studies combined was 1.27 (95% CI 1.18 to 1.38). In analyses limited to only those studies identifying increased risks of lung cancer, the summary RR for stomach cancer was higher (RR=1.41, 95% CI 1.18 to 1.69). Overall, these results suggest that Cr(VI) is a stomach carcinogen in humans, which is consistent with the tumour results reported in rodent studies. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Search for naturally occurring superheavy elements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoughton, R.W.; Halperin, J.; Drury, J.S.

1973-11-12

Several ores, minerals, concentrates and special samples were examined for evidence of superheavy elements using a neutron multiplicity counter. This counter contains 20 /sup 3/He detectors in a paraffin matrix, and enables evaluation of the emitted neutron multiplicity spectrum of large samples with littie or no chemical processing. Such measurements provide an effective tool in the search for superheavy elements, since their decay or the decay of daughter nuclides is expected to proceed by spontaneous fission. In a search for Element 114(ekalead) a massive galena sample and a sample of galena-barite were examined, together with some chalcophilic samples, iron andmore » zinc sulphides, cerussite (PbCO/ sub 3/), and flux dust samples in Cottrell precipitators from the roasting of pentlandite (iron nickel sulphide). Element 114 would be expected to be more volatile than Hg, and intermediate between Pb and Au in nobility, and for this reason a technique was applied which was successfully developed to locate Hg ore bodies. This technique is described. In another attempt to detect possible volatile superheavy elements, such as 118 (ekaradon) or 112 (ekamercury) a sample of silica gel was examined, previously used in a plant for the production of noble gases; a gas mixture of crude Xe from the same plant was also investigated. With regard to Element 110 (ekaplatinum) several ultrabasic rocks were examined. For Element 119 (ekafracium) several potash ores were examined, as well as bittern from the Great Salt Lake, Utah. A sample of native Bi, as well as reagent Bi, were examined for Element 115 (ekabismuth). Several special samples included iron-rich meteorites, samples of biotite in which dwarf haloes had been found, some monazite samples associated with giant haloes, and some haematite and magnetite samples; also manganese nodules, sharks' teeth, and carbonaceous chondrite meteorite samples. The latter were particularly interesting since there is a Xe component in some carbonaceous chondrites that shows a higher /sup 136/Xe/sup 134/Xe ratio than Xe from any known fission source, possibly due to fission of one or more relatively volatile superheavy elements. All the results are summarized in tabular form. None of the samples examined showed evidence of spontaneous fission rates in excess of the detection limit. (UK)« less

7 CFR 1260.118 - Cattle.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.118 Cattle. Cattle means live domesticated bovine animals...

7 CFR 1260.118 - Cattle.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.118 Cattle. Cattle means live domesticated bovine animals...

7 CFR 1260.118 - Cattle.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.118 Cattle. Cattle means live domesticated bovine animals...

7 CFR 1260.118 - Cattle.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Definitions § 1260.118 Cattle. Cattle means live domesticated bovine animals...

View of Morgan in the SPACEHAB Module during the STS-118 Mission

NASA Image and Video Library

2007-08-17

S118-E-07813 (17 Aug. 2007) --- Astronaut Barbara R. Morgan, mission specialist, is surrounded by supplies in SPACEHAB, located in the cargo bay of the Space Shuttle Endeavour. Supply transfer was one of the main activities on the agenda Aug. 17 for the STS-118 crewmembers, who learned their anticipated departure from the International Space Station will come a day earlier due to possible weather issues back home.

Modeling nuclear field shift isotope fractionation in crystals

NASA Astrophysics Data System (ADS)

Schauble, E. A.

2013-12-01

In this study nuclear field shift fractionations in solids (and chemically similar liquids) are estimated using calibrated density functional theory calculations. The nuclear field shift effect is a potential driver of mass independent isotope fractionation(1,2), especially for elements with high atomic number such as Hg, Tl and U. This effect is caused by the different shapes and volumes of isotopic nuclei, and their interactions with electronic structures and energies. Nuclear field shift isotope fractionations can be estimated with first principles methods, but the calculations are computationally difficult, limiting most theoretical studies so far to small gas-phase molecules and molecular clusters. Many natural materials of interest are more complex, and it is important to develop ways to estimate field shift effects that can be applied to minerals, solutions, in biomolecules, and at mineral-solution interfaces. Plane-wave density functional theory, in combination with the projector augmented wave method (DFT-PAW), is much more readily adapted to complex materials than the relativistic all-electron calculations that have been the focus of most previous studies. DFT-PAW is a particularly effective tool for studying crystals with periodic boundary conditions, and may also be incorporated into molecular dynamics simulations of solutions and other disordered phases. Initial calibrations of DFT-PAW calculations against high-level all-electron models of field shift fractionation suggest that there may be broad applicability of this method to a variety of elements and types of materials. In addition, the close relationship between the isomer shift of Mössbauer spectroscopy and the nuclear field shift isotope effect makes it possible, at least in principle, to estimate the volume component of field shift fractionations in some species that are too complex even for DFT-PAW models, so long as there is a Mössbauer isotope for the element of interest. Initial results will be presented for calculations of liquid-vapor fractionation of cadmium and mercury, which indicate an affinity for heavy isotopes in the liquid phase. In the case of mercury the results match well with recent experiments. Mössbauer-calibrated fractionation factors will also be presented for tin and platinum species. Platinum isotope behaviour in metals appears to particularly interesting, with very distinct isotope partitioning behaviour for iron-rich alloys, relative to pure platinum metal. References: 1) Bigeleisen, J. (1996) J. Am. Chem. Soc. 118, 3676-3680. 2) Nomura, M., Higuchi, N., Fujii, Y. (1996) J. Am. Chem. Soc. 118, 9127-9130.

Theoretical studies on the synthesis of SHE 290-302Og (Z=118) using 48Ca, 45Sc, 50Ti, 51V, 54Cr, 55Mn, 58Fe, 59Co and 64Ni induced reactions

NASA Astrophysics Data System (ADS)

Santhosh, K. P.; Safoora, V.

2018-05-01

Using the phenomenological model for production cross section (PMPC), the production cross sections for the synthesis of isotopes of superheavy element Og ( Z = 118) using the fusion reactions 48Ca+249-254Cf → 297-302Og, 45Sc+247,249Bk → 292,294Og, 50Ti + 242-248,250Cm → 292-298,300Og, 51V+241,243Am → 292,294Og, 54Cr + 238-242,244Pu → 292-296,298Og, 55Mn + 235-237Np → 290-292Og, 58Fe + 232-236, 238U → 290-294,296Og, 59Co + 231Pa → 290Og, and 64Ni + 228-230,232Cm → 292-294,296Og in xn (x=3,4,5) evaporation channel have been systematically studied at energies near and above the Coulomb barrier. We have predicted most suitable projectile-target combinations for the synthesis of isotopes 290-302Og among these reactions. Our calculated evaporation residue (ER) cross section values for the reaction 48Ca + 249Cf → 297Og is in excellent agreement with available experimental values. For the synthesis of Og, among all the reactions mentioned above, the 3n channel cross section (2458 fb) is larger for 48Ca + 251Cf → 299Og; 4n channel cross section (212 fb) is larger for 48Ca + 252Cf → 300Og and 5n channel cross section (34 fb) is larger for 48Ca + 253Cf → 301Og. The second largest 3n channel cross section (1143 fb) is obtained for the reaction, 50Ti + 245Cm → 295Og. Our studies will be useful for the future experiments to synthesize the isotopes of element Og which are not synthesized so far. We have also studied the effect of the use of mass values and shell correction of the Warsaw group which leads to a smaller ER cross section compared to the Moller group.

Controlled cell morphology and liver-specific function of engineered primary hepatocytes by fibroblast layer cell densities.

PubMed

Sakai, Yusuke; Koike, Makiko; Kawahara, Daisuke; Hasegawa, Hideko; Murai, Tomomi; Yamanouchi, Kosho; Soyama, Akihiko; Hidaka, Masaaki; Takatsuki, Mitsuhisa; Fujita, Fumihiko; Kuroki, Tamotsu; Eguchi, Susumu

2018-03-05

Engineered primary hepatocytes, including co-cultured hepatocyte sheets, are an attractive to basic scientific and clinical researchers because they maintain liver-specific functions, have reconstructed cell polarity, and have high transplantation efficiency. However, co-culture conditions regarding engineered primary hepatocytes were suboptimal in promoting these advantages. Here we report that the hepatocyte morphology and liver-specific function levels are controlled by the normal human diploid fibroblast (TIG-118 cell) layer cell density. Primary rat hepatocytes were plated onto TIG-118 cells, previously plated 3 days before at 1.04, 5.21, and 26.1×10 3  cells/cm 2 . Hepatocytes plated onto lower TIG-118 cell densities expanded better during the early culture period. The hepatocytes gathered as colonies and only exhibited small adhesion areas because of the pushing force from proliferating TIG-118 cells. The smaller areas of each hepatocyte result in the development of bile canaliculi. The highest density of TIG-118 cells downregulated albumin synthesis activity of hepatocytes. The hepatocytes may have undergone apoptosis associated with high TGF-β1 concentration and necrosis due to a lack of oxygen. These occurrences were supported by apoptotic chromatin condensation and high expression of both proteins HIF-1a and HIF-1b. Three types of engineered hepatocyte/fibroblast sheets comprising different TIG-118 cell densities were harvested after 4 days of hepatocyte culture and showed a complete cell sheet format without any holes. Hepatocyte morphology and liver-specific function levels are controlled by TIG-118 cell density, which helps to design better engineered hepatocytes for future applications such as in vitro cell-based assays and transplantable hepatocyte tissues. Copyright © 2018 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Activation of Beta-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer Cells

PubMed Central

Wan, Xinhai; Liu, Jie; Lu, Jing-Fang; Tzelepi, Vassiliki; Yang, Jun; Starbuck, Michael W.; Diao, Lixia; Wang, Jing; Efstathiou, Eleni; Vazquez, Elba S.; Troncoso, Patricia; Maity, Sankar N.; Navone, Nora M.

2012-01-01

Purpose To study Wnt/beta-catenin in castrate-resistant prostate cancer (CRPC) and understand its function independently of the beta-catenin–androgen receptor (AR) interaction. Experimental Design We performed beta-catenin immunocytochemical analysis, evaluated TOP-flash reporter activity (a reporter of beta-catenin–mediated transcription), and sequenced the beta-catenin gene in MDA PCa 118a, MDA PCa 118b, MDA PCa 2b, and PC-3 prostate cancer (PCa) cells. We knocked down beta-catenin in AR-negative MDA PCa 118b cells and performed comparative gene-array analysis. We also immunohistochemically analyzed beta-catenin and AR in 27 bone metastases of human CRPCs. Results Beta-catenin nuclear accumulation and TOP-flash reporter activity were high in MDA PCa 118b but not in MDA PCa 2b or PC-3 cells. MDA PCa 118a and 118b cells carry a mutated beta-catenin at codon 32 (D32G). Ten genes were expressed differently (false discovery rate, 0.05) in MDA PCa 118b cells with downregulated beta-catenin. One such gene, hyaluronan synthase 2 (HAS2), synthesizes hyaluronan, a core component of the extracellular matrix. We confirmed HAS2 upregulation in PC-3 cells transfected with D32G-mutant beta-catenin. Finally, we found nuclear localization of beta-catenin in 10 of 27 human tissue specimens; this localization was inversely associated with AR expression (P = 0.056, Fisher’s exact test), suggesting that reduced AR expression enables Wnt/beta-catenin signaling. Conclusion We identified a previously unknown downstream target of beta-catenin, HAS2, in PCa, and found that high beta-catenin nuclear localization and low or no AR expression may define a subpopulation of men with bone-metastatic PCa. These findings may guide physicians in managing these patients. PMID:22298898

The alpha-galactosidase A p.Arg118Cys variant does not cause a Fabry disease phenotype: data from individual patients and family studies.

PubMed

Ferreira, Susana; Ortiz, Alberto; Germain, Dominique P; Viana-Baptista, Miguel; Caldeira-Gomes, António; Camprecios, Marta; Fenollar-Cortés, Maria; Gallegos-Villalobos, Ángel; Garcia, Diego; García-Robles, José Antonio; Egido, Jesús; Gutiérrez-Rivas, Eduardo; Herrero, José Antonio; Mas, Sebastián; Oancea, Raluca; Péres, Paloma; Salazar-Martín, Luis Manuel; Solera-Garcia, Jesús; Alves, Helena; Garman, Scott C; Oliveira, João Paulo

2015-02-01

Lysosomal α-galactosidase A (α-Gal) is the enzyme deficient in Fabry disease (FD), an X-linked glycosphingolipidosis caused by pathogenic mutations affecting the GLA gene. The early-onset, multi-systemic FD classical phenotype is associated with absent or severe enzyme deficiency, as measured by in vitro assays, but patients with higher levels of residual α-Gal activity may have later-onset, more organ-restricted clinical presentations. A change in the codon 118 of the wild-type α-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue - GLA p.(Arg118Cys) -, has been recurrently described in large FD screening studies of high-risk patients. Although the Cys118 allele is associated with high residual α-Gal activity in vitro, it has been classified as a pathogenic mutation, mainly on the basis of theoretical arguments about the chemistry of the cysteine residue. However its pathogenicity has never been convincingly demonstrated by pathology criteria. We reviewed the clinical, biochemical and histopathology data obtained from 22 individuals of Portuguese and Spanish ancestry carrying the Cys118 allele, including 3 homozygous females. Cases were identified either on the differential diagnosis of possible FD manifestations and on case-finding studies (n=11; 4 males), or on unbiased cascade screening of probands' close relatives (n=11; 3 males). Overall, those data strongly suggest that the GLA p.(Arg118Cys) variant does not segregate with FD clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease. The Cys118 allelic frequency in healthy Portuguese adults (n=696) has been estimated as 0.001, therefore not qualifying for "rare" condition. Copyright © 2014 Elsevier Inc. All rights reserved.

Mitomycin C retardation of corneal fibroblast migration via sustained dephosphorylation of paxillin at tyrosine 118.

PubMed

Chen, Tsan-Chi; Lai, Chien-Hsueh; Chang, Jie-Ling; Chang, Shu-Wen

2012-03-21

To investigate how mitomycin C (MMC) modulates corneal fibroblast migration and its molecular mechanisms in the wound healing process. After treatment with 0 and 0.2 mg · mL(-1) MMC for 5 minutes, effect of MMC on cell migration of human corneal fibroblasts (HCFs) was examined with a cell migration assay. Both focal adhesion kinase (FAK) and paxillin (PXN) expressions in HCFs were analyzed by semiquantitative real-time PCR, immunoblotting, and immunofluorescence confocal microscopy. Using gene silencing or gene overexpression with lentiviral-based pseudovirion infection, the phosphorylation level of FAK, PXN, and mutated PXNs at tyrosine sites 31 (Y31F-EGFP) and 118 (Y118F-EGFP) were verified in HCFs. MMC retarded HCF migration at 1 and 2 days posttreatment (dpt). MMC reduced levels of FAK transcript and FAK protein, but increased both transcript and protein expression of PXN at 1 and 2 dpt. Furthermore, MMC upregulated FAK-pY397, which subsequently enhanced PXN-pY31 in a dose-dependent manner at 1 dpt. Concurrently, MMC downregulated PXN-pY118 at 1 dpt. However, MMC treatment resulted in dephosphorylation of FAK-pY397, PXN-pY31, and PXN-pY118 at 2 dpt. The FAK/PXN complex in MMC-treated HCFs was detected at focal adhesion sites more than at the leading edge at 1 and 2 dpt, contributing to retardation of HCF migration. Y118F-EGFP-expressing HCFs exhibited lower mobility than that of PXN-EGFP- or Y31F-EGFP-expressing HCFs. The sustained PXN-pY118 dephosphorylation resulted in steadfastness of an incompletely active FAK/PXN complex at focal adhesion sites and played a pivotal role in MMC-retarded HCF migration.

View of Williams during the PMDIS Experiment during STS-118/Expedition 15 Joint Operations

NASA Image and Video Library

2007-08-12

S118-E-06914 (12 Aug. 2007) --- Astronaut Dave Williams, STS-118 mission specialist representing the Canadian Space Agency, works with the Perceptual Motor Deficits in Space (PMDIS) experiment in the Destiny laboratory of the International Space Station. The PMDIS experiment will measure the decline in hand-eye coordination of shuttle astronauts while on orbit. These measurements will be used to evaluate various mechanisms thought to be responsible for the decline.

Degenerative myelopathy in the Collie breed: a retrospective immunohistochemical analysis of superoxide dismutase 1 in an affected Rough Collie, and a molecular epidemiological survey of the SOD1: c.118G>A mutation in Japan

PubMed Central

KOHYAMA, Moeko; KITAGAWA, Masato; KAMISHINA, Hiroaki; KOBATAKE, Yui; YABUKI, Akira; SAWA, Mariko; KAKITA, Shusaku; YAMATO, Osamu

2016-01-01

Canine degenerative myelopathy (DM) is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds. A DM-associated mutation of the canine superoxide dismutase 1 (SOD1) gene, designated as c.118G>A (p.E40K), has been implicated as one of pathogenetic determinants of the disease in many breeds, but it remains to be determined whether the c.118G>A mutation is responsible for development or progression of DM in Collies. Previously, a Rough Collie was diagnosed clinically and histopathologically as having DM in Japan, suggesting the possibility that the Collie breed may be predisposed to DM due to the high frequency of c.118G>A in Japan. In this study, accumulation and aggregate formation of SOD1 protein were retrospectively demonstrated in the spinal cord of the DM-affected dog by immunohistochemical analysis. Furthermore, a molecular epidemiological survey revealed a high carrier rate (27.6%) and mutant allele frequency (0.138) of c.118G>A in a population of Collies in Japan, suggesting that the Collie breed may be predisposed to DM associated with c.118G>A, and the prevention of DM in Collies in Japan should be addressed through epidemiological and genetic testing strategies. PMID:27941298

Structure of sup 118 Sb nucleus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gulyas, J.; Fenyes, T.; Fayez, M.

1992-10-01

{gamma}, {gamma}{gamma}-coincidence, internal conversion electron, and {gamma}-ray angular distribution spectra of the {sup 118}Sn({ital p},{ital n}{gamma}){sup 118}Sb reaction were measured at different bombarding proton energies between 5.5 and 7.5 MeV. {gamma}, {gamma}{gamma}-coincidence, and internal conversion electron spectra of the {sup 115}In ({alpha},{ital n}{gamma}){sup 118}Sb reaction were also measured at {ital E}{sub {alpha}}=14.5 MeV. Ge(HP), Ge(Li), Ge(LEPS) {gamma}-ray detectors, as well as a superconducting magnetic lens electron spectrometer (with Si(Li) detectors), were used in the experiments. About 210 (including {similar to}130 new) {gamma} rays have been assigned to {sup 118}Sb. The deduced {sup 118}Sb level scheme contains more than 70 newmore » levels. On the basis of the internal conversion coefficients, Hauser-Feshbach analysis of ({ital p},{ital n}) reaction cross sections, {gamma}-ray angular distributions, and other arguments spin and parity values have been determined. The parabolic rule'' prediction of the energy splitting of different proton-neutron multiplets enabled the identification of many proton-neutron multiplet states. The energy spectrum and electromagnetic properties have been calculated in the framework of the interacting boson-fermion-fermion--odd-odd truncated quadrupole phonon model, and reasonably good agreement has been obtained between experimental and theoretical results.« less

Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid.

PubMed

Clandinin, M Thomas; Van Aerde, John E; Merkel, Kimberly L; Harris, Cheryl L; Springer, Mary Alice; Hansen, James W; Diersen-Schade, Deborah A

2005-04-01

To evaluate safety and benefits of feeding preterm infants formulas containing docosahexaenoic acid (DHA) and arachidonic acid (ARA) until 92 weeks postmenstrual age (PMA), with follow-up to 118 weeks PMA. This double-blinded study of 361 preterm infants randomized across three formula groups: (1) control, no supplementation; (2) algal-DHA (DHA from algal oil, ARA from fungal oil); and (3) fish-DHA (DHA from fish oil, ARA from fungal oil). Term infants breast-fed > or =4 months (n = 105) were a reference group. Outcomes included growth, tolerance, adverse events, and Bayley development scores. Weight of the algal-DHA group was significantly greater than the control group from 66 to 118 weeks PMA and the fish-DHA group at 118 weeks PMA but did not differ from term infants at 118 weeks PMA. The algal-DHA group was significantly longer than the control group at 48, 79, and 92 weeks PMA and the fish-DHA group at 57, 79, and 92 weeks PMA but did not differ from term infants from 79 to 118 weeks PMA. Supplemented groups had higher Bayley mental and psychomotor development scores at 118 weeks PMA than did the control group. Supplementation did not increase morbidity or adverse events. Feeding formulas with DHA and ARA from algal and fungal oils resulted in enhanced growth. Both supplemented formulas provided better developmental outcomes than unsupplemented formulas.

Recovery of macroinvertebrates by screening in the field: a comparison between coarse (1.18 mm) and fine (0.60 mm) mesh sieves

USGS Publications Warehouse

Dukerschein, J.T.; Gent, R.; Sauer, J.

1996-01-01

We evaluated the potential loss of target benthic macroinvertebrates from coarse-mesh field wash down of samples through a 1.18-mm mesh sieve nested on a 0.60-mm mesh sieve. Visible target organisms (midges, mayflies, and fingernail clams) in the 1.18-mm mesh sieve were removed from the sample and enumerated in the field. The entire contents of both sieves were preserved for subsequent laboratory enumeration under 4X magnification. Percent recoveries from each treatment were based on total intact organisms found in all sieves. Percent recovery for fingernail clams found in the field (31%) was lower than for mayflies (79%) and midges (88%). Laboratory enumeration of organisms retained by the 1.18-mm sieve yielded additional fingernail clams (to total 74% recovered in the field and lab), mayflies (to total 89%), and midges (to total 91%). If the 1.18-mm sieve is used alone in the field, it is adequate to monitor mayflies, midges >1 cm, and adult fingernail clams greater than or equal to 5.0 mm shell length.

Cleanup Verification Package for the 118-H-6:2, 105-H Reactor Ancillary Support Areas, Below-Grade Structures, and Underlying Soils; the 118-H-6:3, 105-H Reactor Fuel Storage Basin and Underlying Soils; The 118-H-6:3 Fuel Storage Basin Deep Zone Side Slope Soils; the 100-H-9, 100-H-10, and 100-H-13 French Drains; the 100-H-11 and 100-H-12 Expansion Box French Drains; and the 100-H-14 and 100-H-31 Surface Contamination Zones

DOE Office of Scientific and Technical Information (OSTI.GOV)

M. J. Appel

2006-06-29

This cleanup verification package documents completion of removal actions for the 105-H Reactor Ancillary Support Areas, Below-Grade Structures, and Underlying Soils (subsite 118-H-6:2); 105-H Reactor Fuel Storage Basin and Underlying Soils (118-H-6:3); and Fuel Storage Basin Deep Zone Side Slope Soils. This CVP also documents remedial actions for the following seven additional waste sties: French Drain C (100-H-9), French Drain D (100-H-10), Expansion Box French Drain E (100-H-11), Expansion Box French Drain F (100-H-12), French Drain G (100-H-13), Surface Contamination Zone H (100-H-14), and the Polychlorinated Biphenyl Surface Contamination Zone (100-H-31).

Determination of diacylhydrazines-type insect growth regulator JS-118 residues in cabbage and soil by high performance liquid chromatography with DAD detection.

PubMed

Hu, J-Y; Deng, Z-B; Qin, D-M

2009-12-01

JS-118 is a diacylhydrazines-type insect growth regulator used extensively in China now. An analytical method for residues determination of JS-118 in cabbage and soil samples by high performance liquid chromatography with DAD detection was established and optimized. Primary secondary amine solid phase extraction cartridge was used for sample preparation. Mean recoveries for the analyte ranged from 96.6% to 107.0% with CV value less than 4.7%. The limit of quantification is 0.01 mg/kg. Direct confirmation of JS-118 residues in samples was realized by high performance liquid chromatography-mass spectrometry. The proposed method is simple, rapid and reliable to perform and could be utilized for monitoring of pesticides residues.

AN/VRC 118 Mid-Tier Networking Vehicular Radio (MNVR) and Joint Enterprise Network Manager (JENM) Early Fielding Report

DTIC Science & Technology

2017-01-18

1 AN/VRC 118 Mid-Tier Networking Vehicular Radio and Joint Enterprise Network Manager Early Fielding Report This report provides my assessment of...the AN/VRC-118 Mid-Tier Networking Vehicular Radio (MNVR) and the Joint Enterprise Network Manager (JENM) in support of the Army’s fielding of low...September 2016 ADM does not address the JENM, which must be fielded with MNVR to allow soldiers to configure and manage the software- defined radio

STS-118 Ascent/Entry Flight Control Team in WFCR

NASA Image and Video Library

2007-09-17

JSC2007-E-46429 (17 Sept. 2007) --- The members of the STS-118 Ascent/Entry flight control team and crewmembers pose for a group portrait in the space shuttle flight control room of Houston's Mission Control Center (MCC). Flight director Steve Stich holds the STS-118 mission logo. Astronauts Scott Kelly, commander, is at left foreground and astronaut Chris Ferguson, spacecraft communicator (CAPCOM), is at right foreground. Additional crewmembers pictured are Charlie Hobaugh, pilot; Barbara R. Morgan, Tracy Caldwell and Rick Mastracchio, all mission specialists.

β 1 Adrenoceptor antagonistic effects of the supposedly selective β 2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts.

PubMed

Pecha, Simon; Flenner, Frederik; Söhren, Klaus-Dieter; Lorenz, Kristina; Eschenhagen, Thomas; Christ, Torsten

2015-10-01

Studies on the relative contribution of β 1- and β 2-adrenoceptors (AR) generally employ selective β 1- and β 2-AR antagonists such as CGP 20712A and ICI 118,551, respectively, and assume that antagonism by one of these compounds indicates mediation by the respective AR subtype. Here, we evaluated the β 2-AR-selectivity of ICI 118,551 in ventricular muscle strips of transgenic mice lacking β 1-AR (β 1-KO), β 2-AR (β 2-KO), or both (β 1/β 2-KO). Strips were electrically driven and force development was measured. In wild type (WT), ICI 118,551 (100 nmol/L) shifted the concentration-response curve (CRC) for adrenaline by about 0.5 log units to the right, corresponding to the known affinity of ICI 118,551 to β 1-AR but not to β 2-AR. Conversely, the phosphodiesterase inhibitor rolipram (10 μmol/L) shifted the CRC to the left, but did not enlarge the ICI 118,551 shift, indicating exclusive β 1-AR mediation even when PDE4 is inactive. In line with this, rolipram and ICI 118,551 had similar effects in β 2-KO than in WT. In contrast, β 1-KO did not show any inotropic reaction to adrenaline (+/- rolipram). In WT, the β 1-AR selective antagonist CGP 20712A (100 nmol/L) shifted the CRC for isoprenaline by 2.1 log units, corresponding to the affinity of CGP 20712A to β 1-AR. Rolipram increased the sensitivity to adrenaline independently of the presence of CGP 20712A. We conclude that effects sensitive to the β 2-AR antagonist ICI 118,551 are not necessarily β 2-AR-mediated and CGP 20712A-resistant effects cannot be simply interpreted as β 2-AR-mediated. Catecholamine effects in murine ventricles strictly depend on β 1-AR, even if PDE 4 is blocked.

β1 Adrenoceptor antagonistic effects of the supposedly selective β2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts

PubMed Central

Pecha, Simon; Flenner, Frederik; Söhren, Klaus-Dieter; Lorenz, Kristina; Eschenhagen, Thomas; Christ, Torsten

2015-01-01

Studies on the relative contribution of β1- and β2-adrenoceptors (AR) generally employ selective β1- and β2-AR antagonists such as CGP 20712A and ICI 118,551, respectively, and assume that antagonism by one of these compounds indicates mediation by the respective AR subtype. Here, we evaluated the β2-AR-selectivity of ICI 118,551 in ventricular muscle strips of transgenic mice lacking β1-AR (β1-KO), β2-AR (β2-KO), or both (β1/β2-KO). Strips were electrically driven and force development was measured. In wild type (WT), ICI 118,551 (100 nmol/L) shifted the concentration–response curve (CRC) for adrenaline by about 0.5 log units to the right, corresponding to the known affinity of ICI 118,551 to β1-AR but not to β2-AR. Conversely, the phosphodiesterase inhibitor rolipram (10 μmol/L) shifted the CRC to the left, but did not enlarge the ICI 118,551 shift, indicating exclusive β1-AR mediation even when PDE4 is inactive. In line with this, rolipram and ICI 118,551 had similar effects in β2-KO than in WT. In contrast, β1-KO did not show any inotropic reaction to adrenaline (+/− rolipram). In WT, the β1-AR selective antagonist CGP 20712A (100 nmol/L) shifted the CRC for isoprenaline by 2.1 log units, corresponding to the affinity of CGP 20712A to β1-AR. Rolipram increased the sensitivity to adrenaline independently of the presence of CGP 20712A. We conclude that effects sensitive to the β2-AR antagonist ICI 118,551 are not necessarily β2-AR-mediated and CGP 20712A-resistant effects cannot be simply interpreted as β2-AR-mediated. Catecholamine effects in murine ventricles strictly depend on β1-AR, even if PDE 4 is blocked. PMID:26516580

Effectiveness of nonporous windscreens for infrasonic measurements.

PubMed

Dauchez, Nicolas; Hayot, Maxime; Denis, Stéphane

2016-06-01

This paper deals with nonporous windscreens used for reducing noise in infrasonic measurements. A model of sound transmission using a modal approach is derived. The system is a square plate coupled with a cavity. The model agrees with finite element simulations and measurements performed on two windscreens: a cubic windscreen using a material recommended by Shams, Zuckerwar, and Sealey [J. Acoust. Soc. Am. 118, 1335-1340 (2005)] and an optimized flat windscreen made out of aluminum. Only the latter was found to couple acoustical waves below 10 Hz without any attenuation. Moreover, wind noise reduction measurements show that nonporous windscreens perform similarly as a pipe array by averaging the pressure fluctuations. These results question the assumptions of Shams et al. and Zuckerwar [J. Acoust. Soc. Am. 127, 3327-3334 (2010)] about compact nonporous windscreens design and effectiveness.

Application of various FLD modelling approaches

NASA Astrophysics Data System (ADS)

Banabic, D.; Aretz, H.; Paraianu, L.; Jurco, P.

2005-07-01

This paper focuses on a comparison between different modelling approaches to predict the forming limit diagram (FLD) for sheet metal forming under a linear strain path using the recently introduced orthotropic yield criterion BBC2003 (Banabic D et al 2005 Int. J. Plasticity 21 493-512). The FLD models considered here are a finite element based approach, the well known Marciniak-Kuczynski model, the modified maximum force criterion according to Hora et al (1996 Proc. Numisheet'96 Conf. (Dearborn/Michigan) pp 252-6), Swift's diffuse (Swift H W 1952 J. Mech. Phys. Solids 1 1-18) and Hill's classical localized necking approach (Hill R 1952 J. Mech. Phys. Solids 1 19-30). The FLD of an AA5182-O aluminium sheet alloy has been determined experimentally in order to quantify the predictive capabilities of the models mentioned above.

Developing a Minimum Data Set for an Information Management System to Study Traffic Accidents in Iran.

PubMed

Mohammadi, Ali; Ahmadi, Maryam; Gharagozlu, Alireza

2016-03-01

Each year, around 1.2 million people die in the road traffic incidents. Reducing traffic accidents requires an exact understanding of the risk factors associated with traffic patterns and behaviors. Properly analyzing these factors calls for a comprehensive system for collecting and processing accident data. The aim of this study was to develop a minimum data set (MDS) for an information management system to study traffic accidents in Iran. This descriptive, cross-sectional study was performed in 2014. Data were collected from the traffic police, trauma centers, medical emergency centers, and via the internet. The investigated resources for this study were forms, databases, and documents retrieved from the internet. Forms and databases were identical, and one sample of each was evaluated. The related internet-sourced data were evaluated in their entirety. Data were collected using three checklists. In order to arrive at a consensus about the data elements, the decision Delphi technique was applied using questionnaires. The content validity and reliability of the questionnaires were assessed by experts' opinions and the test-retest method, respectively. An (MDS) of a traffic accident information management system was assigned to three sections: a minimum data set for traffic police with six classes, including 118 data elements; a trauma center with five data classes, including 57 data elements; and a medical emergency center, with 11 classes, including 64 data elements. Planning for the prevention of traffic accidents requires standardized data. As the foundation for crash prevention efforts, existing standard data infrastructures present policymakers and government officials with a great opportunity to strengthen and integrate existing accident information systems to better track road traffic injuries and fatalities.

Developing a Minimum Data Set for an Information Management System to Study Traffic Accidents in Iran

PubMed Central

Mohammadi, Ali; Ahmadi, Maryam; Gharagozlu, Alireza

2016-01-01

Background: Each year, around 1.2 million people die in the road traffic incidents. Reducing traffic accidents requires an exact understanding of the risk factors associated with traffic patterns and behaviors. Properly analyzing these factors calls for a comprehensive system for collecting and processing accident data. Objectives: The aim of this study was to develop a minimum data set (MDS) for an information management system to study traffic accidents in Iran. Materials and Methods: This descriptive, cross-sectional study was performed in 2014. Data were collected from the traffic police, trauma centers, medical emergency centers, and via the internet. The investigated resources for this study were forms, databases, and documents retrieved from the internet. Forms and databases were identical, and one sample of each was evaluated. The related internet-sourced data were evaluated in their entirety. Data were collected using three checklists. In order to arrive at a consensus about the data elements, the decision Delphi technique was applied using questionnaires. The content validity and reliability of the questionnaires were assessed by experts’ opinions and the test-retest method, respectively. Results: An (MDS) of a traffic accident information management system was assigned to three sections: a minimum data set for traffic police with six classes, including 118 data elements; a trauma center with five data classes, including 57 data elements; and a medical emergency center, with 11 classes, including 64 data elements. Conclusions: Planning for the prevention of traffic accidents requires standardized data. As the foundation for crash prevention efforts, existing standard data infrastructures present policymakers and government officials with a great opportunity to strengthen and integrate existing accident information systems to better track road traffic injuries and fatalities. PMID:27247791

Comparison of serum trace element levels in patients with or without pre-eclampsia.

PubMed

Farzin, Leila; Sajadi, Fattaneh

2012-10-01

In developing countries, nutritional deficiency of essential trace elements is a common health problem, particularly among pregnant women because of increased requirements of various nutrients. Accordingly, this study was initiated to compare trace elements status in women with or without pre-eclampsia. In this study, serum trace elements including zinc (Zn), selenium (Se), copper (Cu), calcium (Ca) and magnesium (Mg) were determined by using atomic absorption spectrometry (AAS) in 60 patients and 60 healthy subjects. There was no significant difference in the values of Cu between two groups (P > 0.05). A significant difference in Zn, Se, Ca and Mg levels were observed between patients with pre-eclampsia and control group (P < 0.001, P<0.01, P<0.01 and P<0.001, respectively). Zn, Se, Ca and Mg levels were found to be 76.49 ± 17.62 μg/ dl, 8.82 ± 2.10 μg/ dl, 8.65 ± 2.14 mg/dl and 1.51 ± 0.34 mg/dl in Pre-eclamptic cases, and these values were found statistically lower compared to the controls (100.61 ± 20.12 μg/dl, 10.47 ± 2.78 μg/dl, 9.77 ± 3.02 mg/dl and 1.78 ± 0.27 mg/dl, respectively). While Cu levels were 118.28 ± 16.92 and 116.55 ± 15.23 μg/dl in the patients and the healthy subjects, respectively. In addition, no significant difference was found between two groups with respect to Hemoglobin Concentration (HbC) and Total White Blood Cell Count (TWBC) (P>0.05). Our findings indicate that the levels of Zn, Se, Ca and Mg are significantly altered in pregnant women with pre-eclampsia. This research shows that these deficiencies can not due to hemodilution.

Belgian speleothems from the Last Interglacial: insights in the onset of glacial conditions in north western Europe.

NASA Astrophysics Data System (ADS)

Vansteenberge, Stef; Verheyden, Sophie; Cheng, Hai; Edwards, Lawrence R.; Keppens, Eddy; Claeys, Philippe

2015-04-01

Currently, a dataset combining at least four speleothems from two different cave systems in southern Belgium (Han-sur-Lesse and Remouchamps) is being constructed to improve the understanding of the termination of the Eemian and the millennial to decadal variability of the Early Glacial times in north western Europe. Here, one of those speleothems is presented. The Han-stm-9 (or 'Triptyque') speleothem is a broken, 68 cm long and candle-shaped stalagmite from the Han-sur-Lesse cave system. The stalagmite was collected in summer 2013 within the southern part of the cave network and was dated between ~126 and ~99ka. Most likely, climate optimum conditions during the 130-125ka interval are linked to the growth of this and other speleothems from Belgian caves. This particular speleothem gained interest because of the partial conformity with the continental interglacial period in northern western Europe (130 - 118ka) and its dense calcite composition with visible layering, excluding post-depositional deformation. Furthermore, the stalagmite displays a complex growth history, with large variations in growth rates (ranging from and periods of ceased speleothem formation. Two hiatuses, with a distinct macroscopic expression, occur. The first one starts at 118.4ka and lasts until 113.0ka. A second hiatus is situated between ~108ka and 103.7ka. A trend in growth rate, consisting of slow growth gradually increasing towards very fast speleothem formation before both hiatuses, is observed. These intervals with very high growth rates, for instance around 118ka, enable high-resolution climate reconstructions via stable isotopes (δ18O and δ13C) and trace elements (Mg, Sr, Ba and P), down to centennial and decadal scale. The timing of the first hiatus corresponds with Greenland Stadial 26 and with the generally accepted termination of the Eemian in northern Europe at 119-118ka. Also, preliminary stable isotope studies have indicated a large detoriation of δ13C occurring right before the second hiatus, while δ18O increases only gradually. This could indicate drastic vegetation changes in the area occurring around the timing of GS25. Furthermore, both δ18O and δ13C time series clearly display millennial to centennial scaled variability during the onset of the Last Glacial. These proxies thus indicate a rather complex glacial-interglacial transition, which is in line with other archives from different locations in Belgium and Europe. Eventually, integrating these findings into a more regional dataset can lead to an improved knowledge of continent-scaled tendencies, such as previously suggested N-S gradients in the onset of Interglacial and Glacial conditions.

40 CFR 92.118 - Analyzer checks and calibrations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Test Procedures § 92.118... sampling system at the sample probe or valve V2 at atmospheric pressure. Simultaneously, start the time...

STS-118 Space Shuttle Crew Honored

NASA Image and Video Library

2007-09-10

A reporter interviews STS-118 Mission Specialist Dave Williams during a special event at Walt Disney World in Orlando . The day's events honoring the STS-118 space shuttle crew recognized the inspirational achievement of teacher-turned-astronaut Barbara R. Morgan who helped dedicate a plaque outside the Mission: Space attraction, and included meeting with students and the media and parading down Main Street to the delight of the crowds. The other crew members attending were Commander Scott Kelly, Pilot Charlie Hobaugh and Mission Specialists Tracy Caldwell, Rick Mastracchio and Alvin Drew. Mission STS-118 was the 119th shuttle program flight and the 22nd flight to the International Space Station. Space shuttle Endeavour launched from NASA's Kennedy Space Center on Aug. 8 and landed Aug. 21. The mission delivered the S5 truss, continuing the assembly of the space station

Effect of hereditary haemochromatosis genotypes and iron overload on other trace elements.

PubMed

Beckett, Jeffrey M; Ball, Madeleine J

2013-02-01

Hereditary haemochromatosis is a common genetic disorder involving dysregulation of iron absorption. There is some evidence to suggest that abnormal iron absorption and metabolism may influence the status of other important trace elements. In this study, the effect of abnormal HFE genotypes and associated iron overload on the status of other trace elements was examined. Dietary data and blood samples were collected from 199 subjects (mean age = 55.4 years; range = 21-81 years). Dietary intakes, serum selenium, copper and zinc concentrations and related antioxidant enzymes (glutathione peroxidase and superoxide dismutase) in subjects with normal HFE genotype (n = 118) were compared to those with abnormal HFE genotype, with both normal iron status (n = 42) and iron overload (n = 39). For most dietary and biochemical variables measured, there were no significant differences between study groups. Red cell GPx was significantly higher in male subjects with normal genotypes and normal iron status compared to those with abnormal genotypes and normal iron status (P = 0.03) or iron overload (P = 0.001). Red cell GPx was also highest in normal women and significantly lower in the abnormal genotype and normal iron group (P = 0.016), but not in the iron overload group (P = 0.078). Although it may not be possible to exclude a small effect between the genotype groups on RBC GPx, overall, haemochromatosis genotypes or iron overload did not appear to have a significant effect on selenium, copper or zinc status.

Chemical characterisation of the globular cluster NGC 5634 associated to the Sagittarius dwarf spheroidal galaxy

NASA Astrophysics Data System (ADS)

Carretta, E.; Bragaglia, A.; Lucatello, S.; D'Orazi, V.; Gratton, R. G.; Donati, P.; Sollima, A.; Sneden, C.

2017-04-01

As part of our on-going project on the homogeneous chemical characterisation of multiple stellar populations in globular clusters (GCs), we studied NGC 5634, associated to the Sagittarius dwarf spheroidal galaxy, using high-resolution spectroscopy of red giant stars collected with VLT/FLAMES. We present here the radial velocity distribution of the 45 observed stars, 43 of which are cluster members, the detailed chemical abundance of 22 species for the seven stars observed with UVES-FLAMES, and the abundance of six elements for stars observed with GIRAFFE. On our homogeneous UVES metallicity scale, we derived a low-metallicity [Fe/H] =-1.867 ± 0.019 ± 0.065 dex (±statistical ±systematic error) with σ = 0.050 dex (7 stars). We found the normal anticorrelations between light elements (Na and O, Mg and Al), a signature of multiple populations typical of massive and old GCs. We confirm the associations of NGC 5634 to the Sgr dSph, from which the cluster was lost a few Gyr ago, on the basis of its velocity and position, and the abundance ratios of α and neutron capture elements. Based on observations collected at ESO telescopes under programme 093.B-0583.Table 2 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/600/A118

A novel thiazolidinedione derivative TD118 showing selective algicidal effects for red tide control.

PubMed

Wu, Ying; Lee, Yew; Jung, Seul-Gi; Kim, Minju; Eom, Chi-Yong; Kim, Si Wouk; Cho, Hoon; Jin, Eonseon

2014-05-01

Thiazolidinedione (TD) derivatives have been found to have an algicidal effect on harmful algal bloom microalgae. In this study, 75 TD derivatives were synthesized and analyzed for algicidal activity. Among these synthetic TDs, 18 TD derivatives showed specific algicidal activity on two strains belonging to the classes Raphidophyceae (Chattonella marina and Heterosigma akashiwo) and Dinophyceae (Cochlodinium polykrikoides). Two strains belonging to Bacillariophyceae (Navicula pelliculosa and Phaeodactylum EPV), one strain belonging to Dinophyceae (Amphidinium sp.), and a Eustigmatophycean microalga (Nannochloropsis oculata) showed less sensitivity to the TD derivatives than the other two phyla. The most reactive TD derivative, compound 2 (TD118), was selected and tested for morphological and physiological changes. TD118 effectively damaged the cell membrane of C. marina, H. akashiwo and C. polykrikoides. The O₂ evolution and photosystem II efficiency (F(v)/F(m)) of C. marina, H. akashiwo and C. polykrikoides were also severely reduced by TD118 treatment. Amphidinium sp., N. pelliculosa, Phaeodactylum EPV and N. oculata showed less reduction of O₂ evolution and the F(v)/F(m) by TD118. These results imply that the species-specific TD structure relationship may be due to structural and/or physiological differences among microalgal species.

118. BENCH SHOP, NORTHWEST CORNER SHOWING ENTRANCE TO ROOM FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. BENCH SHOP, NORTHWEST CORNER SHOWING ENTRANCE TO ROOM FROM OUTSIDE. OFFICE SAFE AT CENTER. - Gruber Wagon Works, Pennsylvania Route 183 & State Hill Road at Red Bridge Park, Bernville, Berks County, PA

Water Quality Conditions in the Missouri River Mainstem System. 2009 Report

DTIC Science & Technology

2010-09-01

Navigation Channel Reach ............................................................................. 117  6.2  Flow Regulation...118  6.2.2  Historic Flow Releases...118  6.2.3  Flow Releases for Water Quality management

23 CFR 635.118 - Payroll and weekly statements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.118 Payroll and weekly statements. For all projects... contract provisions for the project, are to be retained by the STD for the time period pursuant to 49 CFR...

7 CFR 28.118 - When no fee collected for new certificate or memorandum.

Code of Federal Regulations, 2010 CFR

2010-01-01

... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY... United States Cotton Standards Act Fees and Costs § 28.118 When no fee collected for new certificate or...

45 CFR 690.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.118... subjects' involvement will depend upon completion of instruments, prior animal studies, or purification of...

45 CFR 690.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.118... subjects' involvement will depend upon completion of instruments, prior animal studies, or purification of...

45 CFR 690.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.118... subjects' involvement will depend upon completion of instruments, prior animal studies, or purification of...

45 CFR 690.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.118... subjects' involvement will depend upon completion of instruments, prior animal studies, or purification of...

45 CFR 690.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PROTECTION OF HUMAN SUBJECTS § 690.118... subjects' involvement will depend upon completion of instruments, prior animal studies, or purification of...

View of Williams during the PMDIS Experiment during STS-118/Expedition 15 Joint Operations

NASA Image and Video Library

2007-08-12

S118-E-06912 (12 Aug. 2007) --- Astronaut Dave Williams, STS-118 mission specialist representing the Canadian Space Agency, works with the Perceptual Motor Deficits in Space (PMDIS) experiment in the Destiny laboratory of the International Space Station. The PMDIS experiment will measure the decline in hand-eye coordination of shuttle astronauts while on orbit. These measurements will be used to evaluate various mechanisms thought to be responsible for the decline. Astronaut Charlie Hobaugh, pilot, looks on as he floats above Williams.

View of Mastracchio and Williams on EVA 1 during STS-118/Expedition 15 Joint Operations

NASA Image and Video Library

2007-08-11

S118-E-06281 (11 Aug. 2007) --- Astronauts Rick Mastracchio (left) and Canadian Space Agency's Dave Williams, both STS-118 mission specialists, participate in the mission's first planned session of extravehicular activity (EVA), as construction continues on the International Space Station. During the 6-hour, 17-minute spacewalk Mastracchio and Williams attached the Starboard 5 (S5) segment of the station's truss, retracted the forward heat-rejecting radiator from the station's Port 6 (P6) truss, and performed several get-ahead tasks.

Salivaricin P, One of a Family of Two-Component Antilisterial Bacteriocins Produced by Intestinal Isolates of Lactobacillus salivarius▿

PubMed Central

Barrett, Eoin; Hayes, Maria; O'Connor, Paula; Gardiner, Gillian; Fitzgerald, Gerald F.; Stanton, Catherine; Ross, R. Paul; Hill, Colin

2007-01-01

Lactobacillus salivarius DPC6005, a porcine intestinal isolate, produces a two-component bacteriocin, salivaricin P, with homology to ABP-118 produced by a human probiotic L. salivarius strain. Indeed, molecular characterization revealed that while the peptides Sln1 and ABP-118α are identical, their companion peptides (Sln2 and ABP-118β, respectively) differ by two amino acids. This observation suggests that two-component bacteriocins may be a common feature of intestinal L. salivarius strains. PMID:17416691

Remaining Sites Verification Package for the 118-C-3:3, 105-C French Drains, Waste Site Reclassification Form 2006-016

DOE Office of Scientific and Technical Information (OSTI.GOV)

R. A. Carlson

2006-04-24

The 118-C-3:3 french drains received condensate from the steam heating system in the 105-C Reactor Building. The 118-C-3:3 french drain meets the remedial action objectives specified in the Remaining Sites ROD. The results demonstrate that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells.

PubMed

Wan, Xinhai; Liu, Jie; Lu, Jing-Fang; Tzelepi, Vassiliki; Yang, Jun; Starbuck, Michael W; Diao, Lixia; Wang, Jing; Efstathiou, Eleni; Vazquez, Elba S; Troncoso, Patricia; Maity, Sankar N; Navone, Nora M

2012-02-01

To study Wnt/β-catenin in castrate-resistant prostate cancer (CRPC) and understand its function independently of the β-catenin-androgen receptor (AR) interaction. We carried out β-catenin immunocytochemical analysis, evaluated TOP-flash reporter activity (a reporter of β-catenin-mediated transcription), and sequenced the β-catenin gene in MDA prostate cancer 118a, MDA prostate cancer 118b, MDA prostate cancer 2b, and PC-3 prostate cancer cells. We knocked down β-catenin in AR-negative MDA prostate cancer 118b cells and carried out comparative gene-array analysis. We also immunohistochemically analyzed β-catenin and AR in 27 bone metastases of human CRPCs. β-Catenin nuclear accumulation and TOP-flash reporter activity were high in MDA prostate cancer 118b but not in MDA prostate cancer 2b or PC-3 cells. MDA prostate cancer 118a and MDA prostate cancer 118b cells carry a mutated β-catenin at codon 32 (D32G). Ten genes were expressed differently (false discovery rate, 0.05) in MDA prostate cancer 118b cells with downregulated β-catenin. One such gene, hyaluronan synthase 2 (HAS2), synthesizes hyaluronan, a core component of the extracellular matrix. We confirmed HAS2 upregulation in PC-3 cells transfected with D32G-mutant β-catenin. Finally, we found nuclear localization of β-catenin in 10 of 27 human tissue specimens; this localization was inversely associated with AR expression (P = 0.056, Fisher's exact test), suggesting that reduced AR expression enables Wnt/β-catenin signaling. We identified a previously unknown downstream target of β-catenin, HAS2, in prostate cancer, and found that high β-catenin nuclear localization and low or no AR expression may define a subpopulation of men with bone metastatic prostate cancer. These findings may guide physicians in managing these patients.

The alpha-galactosidase A p.Arg118Cys variant does not cause a Fabry disease phenotype: data from individual patients and family studies

PubMed Central

Ferreira, Susana; Ortiz, Alberto; Germain, Dominique P.; Viana-Baptista, Miguel; Gomes, António Caldeira; Camprecios, Marta; Fenollar-Cortés, Maria; Gallegos-Villalobos, Ángel; Garcia, Diego; García-Robles, José Antonio; Egido, Jesús; Gutiérrez-Rivas, Eduardo; Herrero, José Antonio; Mas, Sebastián; Oancea, Raluca; Péres, Paloma; Salazar-Martín, Luis Manuel; Solera-Garcia, Jesús; Alves, Helena; Garman, Scott C.; Oliveira, João Paulo

2015-01-01

Summary Lysosomal α-galactosidase A (α-Gal) is the enzyme deficient in Fabry disease (FD), an X-linked glycosphingolipidosis caused by pathogenic mutations affecting the GLA gene. The early-onset, multi-systemic FD classical phenotype is associated with absent or severe enzyme deficiency, as measured by in vitro assays, but patients with higher levels of residual α-Gal activity may have later-onset, more organ-restricted clinical presentations. A change in the codon 118 of the wild-type α-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue – GLA p.(Arg118Cys) –, has been recurrently described in large FD screening studies of high-risk patients. Although the Cys118 allele is associated with high residual α-Gal activity in vitro, it has been classified as a pathogenic mutation, mainly on the basis of theoretical arguments about the chemistry of the cysteine residue. However its pathogenicity has never been convincingly demonstrated by pathology criteria. We reviewed the clinical, biochemical and histopathology data obtained from 22 individuals of Portuguese and Spanish ancestry carrying the Cys118 allele, including 3 homozygous females. Cases were identified either on the differential diagnosis of possible FD manifestations and on case-finding studies (n=11; 4 males), or on unbiased cascade screening of probands’ close relatives (n=11; 3 males). Overall, those data strongly suggest that the GLA p.(Arg118Cys) variant does not segregate with FD clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease, since the allelic frequency in stroke patients was 0.0087 (p=0.0185 vs the general population). The Cys118 allelic frequency in healthy Portuguese adults (n=696) has been estimated as 0.001, therefore not qualifying for “rare” condition. PMID:25468652

40 CFR 65.118 - Alternative means of emission limitation: Enclosed-vented process units.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Equipment Leaks § 65.118... control device. Process units that are enclosed in such a manner that all emissions from equipment leaks...

42 CFR 84.118 - Half-mask facepieces, full facepieces, and mouthpieces; fit; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.118 Half-mask facepieces, full facepieces, and... reduce the respiratory protective qualities of the gas mask. (c) Half-mask facepieces shall not interfere...

42 CFR 84.118 - Half-mask facepieces, full facepieces, and mouthpieces; fit; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.118 Half-mask facepieces, full facepieces, and... reduce the respiratory protective qualities of the gas mask. (c) Half-mask facepieces shall not interfere...

42 CFR 84.118 - Half-mask facepieces, full facepieces, and mouthpieces; fit; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.118 Half-mask facepieces, full facepieces, and... reduce the respiratory protective qualities of the gas mask. (c) Half-mask facepieces shall not interfere...

42 CFR 84.118 - Half-mask facepieces, full facepieces, and mouthpieces; fit; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.118 Half-mask facepieces, full facepieces, and... reduce the respiratory protective qualities of the gas mask. (c) Half-mask facepieces shall not interfere...

42 CFR 84.118 - Half-mask facepieces, full facepieces, and mouthpieces; fit; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.118 Half-mask facepieces, full facepieces, and... reduce the respiratory protective qualities of the gas mask. (c) Half-mask facepieces shall not interfere...

Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A

PubMed Central

Swetha, Rayapadi G.

2014-01-01

The T118M mutation in PMP22 gene is associated with Charcot Marie Tooth, type 1A (CMT1A). CMT1A is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Mutations in CMT related disorder are seen to increase the stability of the protein resulting in the diseased state. We performed SNP analysis for all the nsSNPs of PMP22 protein and carried out molecular dynamics simulation for T118M mutation to compare the stability difference between the wild type protein structure and the mutant protein structure. The mutation T118M resulted in the overall increase in the stability of the mutant protein. The superimposed structure shows marked structural variation between the wild type and the mutant protein structures. PMID:25400662

118. INTERIOR OF CABLE DISTRIBUTION CABINETS ON NORTHEAST SIDE OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. INTERIOR OF CABLE DISTRIBUTION CABINETS ON NORTHEAST SIDE OF LANDLINE INSTRUMENTATION ROOM (206), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

41 CFR 102-118.385 - What must a waiver request include?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Waivers from Mandatory Prepayment Audit... a prepayment audit increases costs over a postpayment audit, decreases efficiency, involves a...

7 CFR 1280.118 - Promotion.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.118 Promotion. Promotion... information and public relations with emphasis on new marketing strategies, to present a favorable image of U...

Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies.

PubMed

Kim, Dong Hyun; Choe, Yearn Seong; Choi, Joon Young; Lee, Kyung-Han; Kim, Byung-Tae

2011-05-01

Acetylcholinesterase (AChE) has been an important cholinergic factor for the diagnosis of Alzheimer's disease (AD), because of reduced AChE activity in the postmortem brains of AD patients. We previously developed 5,7-dihydro-3-(2-(1-(2-[(18)F]fluorobenzyl)-4-piperidinyl)ethyl)-6H-pyrrolo(3,2,f)-1,2-benzisoxazol-6-one (2-[(18)F]fluoro-CP-118,954) for in vivo studies of AChE in mice. In the present study, we automated the synthesis of 2-[(18)F]fluoro-CP-118,954 for the routine use and evaluated the radioligand by microPET and ex vivo Cerenkov luminescence imaging of mouse AChE. 4-[(18)F]Fluoro-donepezil, another AChE inhibitor, was used for comparison. Automated syntheses of 2-[(18)F]fluoro-CP-118,954 and 4-[(18)F]fluoro-donepezil resulted in high radiochemical yields (25-33% and 30-40%) and high specific activity (27.1-35.4 and 29.7-37.3 GBq/μmol). Brain microPET images of two ICR mice injected with 2-[(18)F]fluoro-CP-118,954 demonstrated high uptake in the striatum (ROI analysis: 5.1 %ID/g for the first 30 min and 4.1 %ID/g for another 30 min), and a blocking study with injection of CP-118,954 into one of the mice at 30 min after radioligand injection led to complete blocking of radioligand uptake in the striatum (ROI analysis: 1.9 %ID/g), whereas (18)F-labeled donepezil did not show specific uptake in the striatum. In another set of experiments, the brain tissues (striatum, parietal cortex, frontal cortex and cerebellum) were excised after brain microPET/CT imaging of mouse injected with 2-[(18)F]fluoro-CP-118,954, and a high striatal uptake was also detected in ex vivo optical and microPET images (ROI analysis: 1.4 %ID/g) and in γ-counting data (2.1 %ID/g at 50 min post-injection) of the brain tissues. Taken together, these results demonstrated that 2-[(18)F]fluoro-CP-118,954 specifically binds to AChE in mouse brains. Copyright © 2011 Elsevier Inc. All rights reserved.

7 CFR 4280.118 - Insurance requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Renewable Energy System and Energy Efficiency Improvement Grants § 4280.118 Insurance requirements... is required except for projects with total eligible project costs of $200,000 or less. ...

7 CFR 4280.118 - Insurance requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Renewable Energy System and Energy Efficiency Improvement Grants § 4280.118 Insurance requirements... is required except for projects with total eligible project costs of $200,000 or less. ...

7 CFR 4280.118 - Insurance requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Energy for America Program General Renewable Energy System and Energy Efficiency Improvement Grants § 4280.118 Insurance requirements... is required except for projects with total eligible project costs of $200,000 or less. ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, K.S.

Norepinephrine has previously been demonstrated by this laboratory to potentiate the in vitro T-dependent antibody response through the stimulation of {beta}-adrenergic receptors. The role of {beta}-adrenergic receptor subtypes in norepinephrine-induced potentiation of the antibody responses was examined with selective {beta}-adrenergic antagonists. The antagonists were metoprolol ({beta}{sub 1}-selective), ICI 118-551 ({beta}{sub 2}-selective), and propranolol ({beta}-non-selective). Both propranolol and ICI 118-551 blocked norepinephrine-induced potentiation of the antibody response, but metoprolol was ineffective. Receptor binding competition of antagonists with the radioligant, ({sup 3}H)CGP-12177 was examined and results were analyzed with the computer program, LIGAND. Competition by ICI 118-551 identified 75% {beta}{sub 2}- andmore » 25% {beta}{sub 1}-adrenergic receptors on splenic mononuclear cells. Enriched T lymphocytes exhibited 75% {beta}{sub 2}-adrenergic receptors, while enriched B lymphocytes contained 90% {beta}{sub 2}-adrenergic receptors as identified by ICI 118-551. Greater than twice as many total receptors were identified on B lymphocytes than T lymphocytes. A T cell lymphoma contained about 60% {beta}{sub 2}-receptors, while 100% were {beta}{sub 2} receptors on a B cell lymphoma, as assessed by ICI 118-551. Results support a heterogeneous {beta}-adrenergic receptor population on T lymphocytes and a more homogeneous {beta}{sub 2}-population on B lymphocytes.« less

Emergency Medical Service Information System:the ARES 118 experience.

PubMed

Ientile, D A; Cardinale, M A; Cataldi, S; Parafati, M; Pasquarella, A; Trani, N; Corradi, M P

2017-01-01

In this paper we describe ARES 118, the prehospital Emergency Medical Service of the Region Lazio, Italy, focusing on its data system used to populate a data warehouse and to create ad hoc reports. ARES 118 is a regional public mono-specialized health company, established in 2004, that manages the emergency care throughout the Region Lazio. Being a peculiar company in its kind, and being the first experience of this kind in Italy, ARES 118 has begun to equip itself, in an autonomous way, with a corporate information system, starting from what already existed as data collection from the individual provincial operating Centers and then by activating a unique information system at a regional and company level by deploying a data warehouse. All operations were carried out using open source software. Currently, ARES 118 is equipped with a business information system that enables data collection with its storage, management and processing of the same in fairly and easy way. The system allows the production of specific reports and measures modulated on the user requests in order to highlight the different aspects of the activity. The production of ad hoc reports, with the possibility of developing specific indicators, allows the identification and analysis of critical areas/processes in order to implement any corrective actions and monitor the effectiveness of the sam.

RF characteristics of the hoop column antenna for the land mobile satellite system mission

NASA Astrophysics Data System (ADS)

Foldes, P.

1984-11-01

A communication system using a satellite with a 118 meter diameter quad aperture antenna to provide telephone service to mobile users remotely located from the large metropolitan areas where the telephone companies are presently implementing their cellular system is described. In this system, which is compatible with the cellular system, the mobile user communicates with the satellite at UHF frequencies. The satellite connects him at S-Band, to the existing telephone network via a base station. The results of the RF definition work for the quad aperture antenna are presented. The elements of the study requirements for the LMSS are summarized, followed by a beam topology plan which satisfies the mission requirements with a practical and realiable configuration. The geometry of the UHF antenna and its radiation characteristics are defined. The various feed alternatives, and the S-band aperture are described.

Finding Relevant Parameters for the Thin-film Photovoltaic Cells Production Process with the Application of Data Mining Methods.

PubMed

Ulaczyk, Jan; Morawiec, Krzysztof; Zabierowski, Paweł; Drobiazg, Tomasz; Barreau, Nicolas

2017-09-01

A data mining approach is proposed as a useful tool for the control parameters analysis of the 3-stage CIGSe photovoltaic cell production process, in order to find variables that are the most relevant for cell electric parameters and efficiency. The analysed data set consists of stage duration times, heater power values as well as temperatures for the element sources and the substrate - there are 14 variables per sample in total. The most relevant variables of the process have been found based on the so-called random forest analysis with the application of the Boruta algorithm. 118 CIGSe samples, prepared at Institut des Matériaux Jean Rouxel, were analysed. The results are close to experimental knowledge on the CIGSe cells production process. They bring new evidence to production parameters of new cells and further research. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

RF characteristics of the hoop column antenna for the land mobile satellite system mission

NASA Technical Reports Server (NTRS)

Foldes, P.

1984-01-01

A communication system using a satellite with a 118 meter diameter quad aperture antenna to provide telephone service to mobile users remotely located from the large metropolitan areas where the telephone companies are presently implementing their cellular system is described. In this system, which is compatible with the cellular system, the mobile user communicates with the satellite at UHF frequencies. The satellite connects him at S-Band, to the existing telephone network via a base station. The results of the RF definition work for the quad aperture antenna are presented. The elements of the study requirements for the LMSS are summarized, followed by a beam topology plan which satisfies the mission requirements with a practical and realiable configuration. The geometry of the UHF antenna and its radiation characteristics are defined. The various feed alternatives, and the S-band aperture are described.

Growth and characterization of chalcostibite CuSbSe2 thin films for photovoltaic application

NASA Astrophysics Data System (ADS)

Tiwari, Kunal J.; Vinod, Vijay; Subrahmanyam, A.; Malar, P.

2017-10-01

Bulk copper antimony selenide was synthesized using mechanical alloying from the elemental precursors. Phase formation in milled powders was studied using x-ray diffraction (XRD) and Raman spectroscopy studies. The synthesized bulk source after cold compaction was used as source material for thin film deposition by e-beam evaporation. Thin film deposition was carried out at various e-beam current values (Ib ∼30, 40 and 50 mA) and at a substrate temperature of 200 °C. Near stoichiometric CuSbSe2 thin films were obtained for Ib values closer to 50 mA and post annealing at a temperature of 380 °C for 1 h. Thin films deposited using above conditions were found to exhibit an absorption coefficient (α) values of >105 cm-1 and a band gap value ∼1.18 eV that is closer to the reported band gap for CuSbSe2 compound.

Noble-metal-free g-C3N4/Ni(dmgH)2 composite for efficient photocatalytic hydrogen evolution under visible light irradiation

NASA Astrophysics Data System (ADS)

Cao, Shao-Wen; Yuan, Yu-Peng; Barber, James; Loo, Say Chye Joachim; Xue, Can

2014-11-01

We report an economic photocatalytic H2 generation system consisting of earth-abundant elements only by coupling graphitic carbon nitride (g-C3N4) with Ni(dmgH)2 sub-microwires that serve as effective co-catalysts for H2 evolution. This composite photocatalyst exhibits efficient hydrogen evolution under visible-light irradiation in the presence of triethanolamine as electron donor. The optimal coupling of 3.5 wt% Ni(dmgH)2 to g-C3N4 (5 mg composite) allows for a steady H2 generation rate of 1.18 μmol/h with excellent stability. This study demonstrates that the combination of polymeric g-C3N4 semiconductor and small proportion of transition-metal-based co-catalyst could serve as a stable, earth-abundant and low-cost system for solar-to-hydrogen conversion.

Nuclear Data Sheets for A = 235

DOE Office of Scientific and Technical Information (OSTI.GOV)

Browne, E.; Tuli, J.K.

Spectroscopic data and level schemes from radioactive decay and nuclear reaction studies are presented here for all nuclei with mass number A=235. The highlight of this evaluation consists of the precise and comprehensive Coulomb excitation study (2012Wa35) on {sup 235}U, which in addition to the 7/2[743] ground state rotational band, extended the 1/2[631], 5/2[622], 5/2[752], and 3/2[631] rotational bands up to Jπ=53/2+, 49/2+, 441/2−, and 43/2+, respectively. This evaluation presents a study (2010Hu02) of the {sup 237}Np({sup 116}Sn, {sup 118}Snγ) reaction where the ground state rotational band 5/2[642] was observed up to Jπ=(53/2+). It is worth for historical knowledge tomore » mention the report on the “Discovery of isotopes of the transuranium elements with 93≤Z≤98” (2013Fr02), where the information for elements Np, Pu, and Am with mass number A=235 is given. {sup 235}Cf has not been observed. The alpha hindrance factors (HF) presented in this evaluation were calculated using values of the radius parameter (r{sub 0}) interpolated from those for even–even adjacent nuclei given by 1998Ak04.« less

A systematic review of the published literature on team-based learning in health professions education.

PubMed

Reimschisel, Tyler; Herring, Anna L; Huang, Jennifer; Minor, Tara J

2017-12-01

Summarize the published literature on team-based learning (TBL) in health professions education (HPE) using the TBL conceptual framework to identify gaps that can guide future research Methods: PubMed, Web of Science, ERIC, and Google Scholar were searched through May 2016 for English-language articles regarding the use of TBL in HPE. Reviewers independently extracted data and coded for the seven elements in Michaelsen's Model of TBL. A total of 118 articles met inclusion criteria. The number of articles published yearly on TBL has grown steadily, more than tripling between 2011 and 2016. Most studies (55; 47%) involved undergraduate medical students and took place in the US (72; 61%). The most commonly studied framework component was Teacher and Learner Attitudes (97; 82%). Other commonly studied elements included Learning Outcomes (85; 72%) and Team Characteristics (25; 21%). Contextual Factors affecting TBL was addressed in one study. A substantial body of literature examines the effect that TBL has on traditional measures of achievement. However, many dimensions of TBL have not been well studied, including Teacher Decisions about TBL, Contextual Factors that affect TBL, Learners' Engagement, and Pattern of Engagement within Teams. Future research in these areas could determine the best use of TBL in HPE.

The pH-dependent release of platinum group elements (PGEs) from gasoline and diesel fuel catalysts: Implication for weathering in soils.

PubMed

Suchá, Veronika; Mihaljevič, Martin; Ettler, Vojtěch; Strnad, Ladislav

2016-04-15

Powdered samples of new and old gasoline catalysts (Pt, Pd, Rh) and new and old diesel (Pt) catalysts were subjected to a pH-static leaching procedure (pH 2-9) coupled with thermodynamic modeling using PHREEQC-3 to verify the release and mobility of PGEs (platinum group elements). PGEs were released under acidic conditions, mostly exhibiting L-shaped leaching patterns: diesel old: 5.47, 0.005, 0.02; diesel new: 68.5, 0.23, 0.11; gasoline old: 0.1, 11.8, 4.79; gasoline new 2.6, 25.2, 35.9 in mg kg(-1) for Pt, Pd and Rh, respectively. Only the new diesel catalyst had a strikingly different leaching pattern with elevated concentrations at pH 4, probably influenced by the dissolution of the catalyst carrier and washcoat. The pH-static experiment coupled with thermodynamic modeling was found to be an effective instrument for understanding the leaching behavior of PGEs under various environmental conditions, and indicated that charged Pt and Rh species may be adsorbed on the negatively charged surface of kaolinite or Mn oxides in the soil system, whereas uncharged Pd and Rh species may remain mobile in soil solutions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Combinatorial Platform for Discovery of Nanocrystal-Ink Based Earth Abundant Element PV with Efficiency Greater than 20%

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hillhouse, Hugh W.

(1) We successfully developed an ultrasonic spray coating system that can be used to deposit thin chalcogenide films with composition gradients. 4 publications under the contract have been published with the instrument. The instrument was used to reveal the effects of intrinsic composition and examine the effects of 25 different dopant elements. Surprisingly, doping with most elements had little to no effect on the quasi-Fermi level splitting of bare films. Ge and Li were explored in depth, and our best devices utilize lithium doping. (2) We developed a new model of absorption coefficients, that when combined with absolute intensity photoluminescence,more » yield the steady-state quasi-Fermi level splitting and a way to quantify the sub-bandgap absorption. This has resulted in 2 publications on the method, with another in preparation. This is a significant development that should impact other PV technologies. (3) We found that lithium doping has several beneficial effects on CZTSSe. It improves the open-circuit voltage, short circuit current, fill factor, and shunt resistance. By using scanning Kelvin probe microscopy (SKPM) and conductive AFM (along with device measurements, DLPC, and XPS), we discovered that lithium acts to increase the p-type doping in both the grain and grain boundaries (GBs). The effect is stronger in the GBs and changes the direction of the electric field at the GB. In lithium doped devices, an electric field repels minority carrier electrons away from the GB. This resulted in a publication and the fabrication of 11.8% efficient devices from a DMSO-thiourea molecular ink. The mechanism of action is most likely due to the formation of LiCu, which inhibits the formation of the donor defect ZnCu. This reduces compensation and increases the net p-type doping. (4) By alloying with germanium, we have fabricated CZTGSSe devices with the best open-circuit voltage (relative the maximum theoretical open-circuit voltage for the bandgap) for any kesterite solar cell. The Voc/Voc,max is 63%, compared to 58% for the record efficiency cell from hydrazine. The origin of the increased voltage efficiency appears to be related to the conduction band off-set and the suppression of a deep defect (~0.8 eV), most likely due to CuSn, but SnZn or SnCu are also possible. All milestones and go/no-go metrics were met with exception of the device efficiency milestone (15% then 20%). However, under the contract, hydrazine-free CZTSSe device efficiencies increased from 7.2% at the start of the contract to 11.8% upon completion.« less

25 CFR 224.118 - How must the tribe respond to the Director's notice of the opportunity for a hearing?

Code of Federal Regulations, 2010 CFR

2010-04-01

... THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Interested Party Petitions § 224.118 How must the tribe respond to the...

25 CFR 224.118 - How must the tribe respond to the Director's notice of the opportunity for a hearing?

Code of Federal Regulations, 2011 CFR

2011-04-01

... THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Interested Party Petitions § 224.118 How must the tribe respond to the...

40 CFR 745.118 - Enforcement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 745.118 Enforcement. (a) Any...

40 CFR 745.118 - Enforcement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 745.118 Enforcement. (a) Any...

40 CFR 745.118 - Enforcement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 745.118 Enforcement. (a) Any...

40 CFR 745.118 - Enforcement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 745.118 Enforcement. (a) Any...

40 CFR 745.118 - Enforcement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 745.118 Enforcement. (a) Any...

Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production.

PubMed

Miyauchi, Eiji; O'Callaghan, John; Buttó, Ludovica F; Hurley, Gráinne; Melgar, Silvia; Tanabe, Soichi; Shanahan, Fergus; Nally, Kenneth; O'Toole, Paul W

2012-11-01

Enhanced barrier function is one mechanism whereby commensals and probiotic bacteria limit translocation of foreign antigens or pathogens in the gut. However, barrier protection is not exhibited by all probiotic or commensals and the strain-specific molecules involved remain to be clarified. We evaluated the effects of 33 individual Lactobacillus salivarius strains on the hydrogen peroxide (H(2)O(2))-induced barrier impairment in human epithelial Caco-2 cells. These strains showed markedly different effects on H(2)O(2)-induced reduction in transepithelial resistance (TER). The effective strains such as UCC118 and CCUG38008 attenuated H(2)O(2)-induced disassembly and relocalization of tight junction proteins, but the ineffective strain AH43324 did not. Strains UCC118 and CCUG38008 induced phosphorylation of extracellular signal-regulated kinase (ERK) in Caco-2 cells, and the ERK inhibitor U0126 attenuated the barrier-protecting effect of these strains. In contrast, the AH43324 strain induced phosphorylation of Akt and p38, which was associated with an absence of a protective effect. Global transcriptome analysis of UCC118 and AH43324 revealed that some genes in a bacteriocin gene cluster were upregulated in AH43324 under TER assay conditions. A bacteriocin-negative UCC118 mutant displayed significantly greater suppressive effect on H(2)O(2)-induced reduction in TER compared with wild-type UCC118. The wild-type strain augmented H(2)O(2)-induced phosphorylation of Akt and p38, whereas a bacteriocin-negative UCC118 mutant did not. These observations indicate that L. salivarius strains are widely divergent in their capacity for barrier protection, and this is underpinned by differences in the activation of intracellular signaling pathways. Furthermore, bacteriocin production appears to have an attenuating influence on lactobacillus-mediated barrier protection.

The impact of alcohol-related presentations on a New Zealand hospital emergency department.

PubMed

Stewart, Rebecca; Das, Manidipa; Ardagh, Michael; Deely, Joanne M; Dodd, Stuart; Bartholomew, Nadia; Pearson, Scott; Spearing, Ruth; Williams, Tracey; Than, Martin

2014-08-29

To determine the impact of alcohol-related presentations on the Christchurch Hospital Emergency Department (ED). Over 42 8-hour shifts (2 weeks) between 15 November 2013 and 9 December 2013, patients attending the ED with recent alcohol consumption were classified as screen-positive (consumed alcohol in the 4 hours prior to presentation) or not. A subset of screen-positive patients was classified as impact-positive (alcohol consumption clearly contributed to the reason for presenting). Data were analysed in relation to days/shifts for gender, age, disruptive behaviour, medical reasons for presenting, and completeness of ED records. Of the 3619 patients screened in the study, 268 (7.4%) and 182 (5%) were screen-positive and impact-positive, respectively. Most patients attended the ED on the weekends (58%: 105/182), particularly on Saturday night (31%; 56/182). More males (118) than females (64) were impact-positive. Of the impact-positive males, most were 16-25 years old (37%; 44/118) or 41-61 years old (32%; 38/118), attended the ED on weekend night shifts (24%; 28/118), and sought treatment for non- interpersonal trauma (38%; 45/118) or interpersonal trauma due to violence (17%; 20/118). Of the female impact-positive patients, most were 16-25 years old (41%; 26/64) or 41-60 years old (33%; 21/64), and presented for deliberate self-harm (36%; 23/64) or non-interpersonal trauma (27%; 17/64). Of the 182 impact-positive patients, 86% (156) were recorded in the ED computer system. Alcohol-related presentations had a significant impact on the ED, particularly on weekends. Teenagers, young adults and middle-aged adults contributed to the alcohol-related patient impact on weekends. Male patients were a significant burden on Saturday evening and night shifts.

Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study.

PubMed

Ginosar, Y; Davidson, E M; Meroz, Y; Blotnick, S; Shacham, M; Caraco, Y

2009-09-01

There are diverse reports concerning the single-nucleotide polymorphism (SNP) A118G in the gene coding for the mu-opioid receptor. This study assessed pharmacokinetic-pharmacodynamic relationships in patients with acute pain (water-immersed extracorporeal shock wave lithotripsy). Ninety-nine patients (ASA I-II, age 18-70) were assessed in this prospective observational study. Blinding was achieved by determining genotype only after the procedure. I.V. alfentanil was administered by patient-controlled administration (loading dose, 10 microg kg(-1); continuous infusion, 20 microg kg(-1) h(-1); bolus, 3 microg kg(-1); lockout time, 1 min); no other analgesic or sedating medication was used. The allelic frequency was 15.2% in our population. The G118 SNP (AG/GG) was associated with a 27% increase in plasma alfentanil concentration (P=0.034), a 54% increase in alfentanil dose (P=0.009), a 47% increase in dose per kg body weight (P=0.004), a 55% increase in dose per kg corrected for stimulus intensity (P=0.002), a 112% increase in the numbers of attempted boluses (P=0.015), a 79% increase in the numbers of successful boluses (P=0.013), and a 153% increase in the numbers of failed boluses (P=0.042). Despite the increased alfentanil self-administration, the G118 SNP was associated with a 52% increase in verbal analogue pain scores over the same period of time (P=0.047). We demonstrated increased opioid requirement for alfentanil in patients with the G118 SNP, who self-administered a higher dose, achieved higher plasma concentration, and yet complained of more severe pain. This observation suggests that G118 SNP impairs the analgesic response to opioids.

ACTS 118x Final Report High-Speed TCP Interoperability Testing

NASA Technical Reports Server (NTRS)

Ivancic, William D.; Zernic, Mike; Hoder, Douglas J.; Brooks, David E.; Beering, Dave R.; Welch, Arun

1999-01-01

With the recent explosion of the Internet and the enormous business opportunities available to communication system providers, great interest has developed in improving the efficiency of data transfer using the Transmission Control Protocol (TCP) of the Internet Protocol (IP) suite. The satellite system providers are interested in solving TCP efficiency problems associated with long delays and error-prone links. Similarly, the terrestrial community is interested in solving TCP problems over high-bandwidth links. Whereas the wireless community is interested in improving TCP performance over bandwidth constrained, error-prone links. NASA realized that solutions had already been proposed for most of the problems associated with efficient data transfer over large bandwidth-delay links (which include satellite links). The solutions are detailed in various Internet Engineering Task Force (IETF) Request for Comments (RFCs). Unfortunately, most of these solutions had not been tested at high-speed (155+ Mbps). Therefore, the NASA's ACTS experiments program initiated a series of TCP experiments to demonstrate scalability of TCP/IP and determine how far the protocol can be optimized over a 622 Mbps satellite link. These experiments were known as the 118i and 118j experiments. During the 118i and 118j experiments, NASA worked closely with SUN Microsystems and FORE Systems to improve the operating system, TCP stacks. and network interface cards and drivers. We were able to obtain instantaneous data throughput rates of greater than 520 Mbps and average throughput rates of 470 Mbps using TCP over Asynchronous Transfer Mode (ATM) over a 622 Mbps Synchronous Optical Network (SONET) OC12 link. Following the success of these experiments and the successful government/industry collaboration, a new series of experiments. the 118x experiments. were developed.

118. JOB NO. 1347M, SHEET 2, 1930/1931, ADDITION FOR PRESSED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. JOB NO. 1347-M, SHEET 2, 1930/1931, ADDITION FOR PRESSED STEEL DEPARTMENT FOR FORD MOTOR COMPANY; FIRST FLOOR PLAN - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

118. #3 SHAFT ALLEY (PROPELLER SHAFT) FORWARD LOOKING AFT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

118. #3 SHAFT ALLEY (PROPELLER SHAFT) - FORWARD LOOKING AFT ON PORT SIDE SHOWING THE SHAFT, SHAFT PACKING GLAND, SHAFT SEAL COOLING WATER LINE AND FIVE INCH FIRE MAIN PIPING. - U.S.S. HORNET, Puget Sound Naval Shipyard, Sinclair Inlet, Bremerton, Kitsap County, WA