Sample records for element 134
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Dion, Michael; Eiden, Greg; Farmer, Orville
2016-07-22
A developed technique that uses the intrinsic mass-based separation capability of a quadrupole mass spectrometer has been used to resolve spectral radiometric interference of two isotopes of the same element. In this work the starting sample was a combination of 137Cs and 134Cs and was (activity) dominated by 137Cs and this methodology separated and “implanted” 134Cs that was later quantified for spectral features and ac- tivity with traditional radiometric techniques. This work demonstrated a 134Cs/137Cs activity ratio enhancement of >4 orders of magnitude and complete removal of 137Cs spectral features from the implanted target mass (i.e., 134).
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Interspecific comparison of radiocesium trophic transfer in two tropical fish species.
Pouil, Simon; Teyssié, Jean-Louis; Fowler, Scott W; Metian, Marc; Warnau, Michel
2018-09-01
The trophic transfer of radiocesium ( 134 Cs) was investigated in two tropical fish, the silver moony Monodactylus argenteus and the spotted scat Scatophagus argus. Juveniles of both species were exposed to dietary 134 Cs using the pulse-chase feeding methodology. The food was brine shrimp (Artemia salina) previously exposed to the dissolved radiotracer. Depuration kinetics of 134 Cs were followed for 45 d. Results showed that Cs was similarly efficiently assimilated by both species (AE > 50%). The estimated trophic transfer factors in the two species ranked from 1 to 2, suggesting that 134 Cs could be biomagnified in both omnivorous species. In complement, dissections of 7 body compartments were carried out at three different times in order to highlight 134 Cs organotropism. 134 Cs organotropism was similar in both species: more than 50% of 134 Cs was quickly distributed in the muscles and skeleton (after 3 days of depuration), which is likely related to the analogous behavior between Cs and K, an essential element for muscle contractions and bone formation. Copyright © 2018 Elsevier Ltd. All rights reserved.
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NASA Technical Reports Server (NTRS)
Cramer, P. W., Jr. (Inventor)
1985-01-01
The network, which is connected to a layer of 134 feed elements that transmit and receive microwaves, consists of a pair of circuit boards parallel to the feed element layer. One of the two boards has 87 dividers that each divide a signal to be transmitted into seven portions, and the other board has 134 combiners that each collect seven transmit signal portions and deliver the sum to one of the feed elements. A similar arrangement is used to handle received signals. The large number of interconnections are made by printed circuit conductors radiating from each of the numerous dividers and combiners, and by providing interconnection pins that interconnect the ends of pairs of conductors lying on the two boards. The printed circuit conductors extend in undulating paths that provide maximum separation of conductors to minimize crosstalk.
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Nitromethane Bridged Bis(1,3,4-oxadiazoles): Trianionic Energetic Salts with Low Sensitivities.
Yu, Qiong; Imler, Gregory H; Parrish, Damon A; Shreeve, Jean'ne M
2017-12-14
Trianionic energetic salts based on one nitromethylene and two dinitromethyl anions were designed and synthesized. Interestingly, the unstable dinitromethylene group of diethyl 2,2'-((dinitromethylene)bis(1,3,4-oxadiazole-5,2-diyl))bis(2,2-dinitroacetate) (2) was changed to a mononitromethylene group by an aminolysis reaction to form triammonium ((nitromethanidylene)bis(1,3,4-oxadiazole-5,2-diyl))bis(dinitromethanide) (3), whereas in (dinitrobis(5-(trinitromethyl)-1,3,4-oxadiazol-2-yl)methan) 8 it was hydrolyzed to a carbonyl group resulting in (bis(5-(trinitromethyl)-1,3,4-oxadiazol-2-yl)methanone) 9. All the new compounds were fully characterized by infrared, multinuclear NMR spectra, and elemental analysis. The structures of triammonium ((nitromethanidylene)bis(1,3,4-oxadiazole-5,2-diyl))bis(dinitromethanide) dihydrate (3⋅2 H 2 O) and bis(2-dinitromethyl-1,3,4-oxadiazole-5-yl)methanone (9) were further confirmed by single-crystal X-ray diffraction analysis. Based on their different physical and detonation properties, some of the energetic salts were found to exhibit good energetic performance and low sensitivity. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Ganesh, Shimoga D.; Pai, Vasantakumar K.; Kariduraganavar, Mahadevappa Y.; Jayanna, Madhu B.
2014-01-01
Poly(1,3,4-oxadiazole-ether) with reactive carboxylic acid pendants was synthesized from solution polymerization via nucleophilic displacement polycondensation among 2,5-bis(4-fluorophenyl)-1,3,4-oxadiazole (BFPOx) and 4,4′-bis(4-hydroxyphenyl) valeric acid (BHPA). Without altering the polymeric segments, benzimidazole modified poly(1,3,4-oxadiazole-ether)s were prepared by varying stoichiometric ratios of 1,2-phenylenediamine. The molecular structural characterization of these polymers was achieved by, FT-IR, NMR, TGA, elemental analysis, and analytical techniques. The weight-average molecular weight of virgin polymer with carboxylic acid functionality was determined by gel permeation chromatography (GPC) and was found to be 22400 (Mw/Mn = 2.07). All the synthesized polyethers were compressed into pellets and electrical contacts were established to perform dielectric properties. PMID:27437448
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STS-134 crew and Expedition 24/25 crew member Shannon Walker
2010-03-25
JSC2010-E-043667 (25 March 2010) --- NASA astronaut Mark Kelly, STS-134 commander, uses the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of his duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements.
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STS-134 crew and Expedition 24/25 crew member Shannon Walker
2010-03-25
JSC2010-E-043666 (25 March 2010) --- NASA astronauts Mark Kelly (background), STS-134 commander; and Andrew Feustel, mission specialist, use the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of their duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements.
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STS-134 crew and Expedition 24/25 crew member Shannon Walker
2010-03-25
JSC2010-E-043668 (25 March 2010) --- NASA astronauts Mark Kelly (background), STS-134 commander; and Andrew Feustel, mission specialist, use the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of their duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements.
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STS-134 crew and Expedition 24/25 crew member Shannon Walker
2010-03-25
JSC2010-E-043673 (25 March 2010) --- NASA astronauts Gregory H. Johnson, STS-134 pilot; and Shannon Walker, Expedition 24/25 flight engineer, use the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of their duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements.
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STS-134 crew and Expedition 24/25 crew member Shannon Walker
2010-03-25
JSC2010-E-043661 (25 March 2010) --- NASA astronauts Gregory H. Johnson, STS-134 pilot; and Shannon Walker, Expedition 24/25 flight engineer, use the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of their duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements.
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STS-134 crew in Virtual Reality Lab during their MSS/EVAA SUPT2 Team training
2010-08-27
JSC2010-E-121049 (27 Aug. 2010) --- NASA astronaut Andrew Feustel (foreground), STS-134 mission specialist, uses the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of his duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements. Photo credit: NASA or National Aeronautics and Space Administration
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STS-134 crew and Expedition 24/25 crew member Shannon Walker
2010-03-25
JSC2010-E-043662 (25 March 2010) --- NASA astronauts Gregory H. Johnson, STS-134 pilot; and Shannon Walker, Expedition 24/25 flight engineer, use the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of their duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements.
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STS-134 crew in Virtual Reality Lab during their MSS/EVAA SUPT2 Team training
2010-08-27
JSC2010-E-121056 (27 Aug. 2010) --- NASA astronaut Gregory H. Johnson, STS-134 pilot, uses the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of his duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements. Photo credit: NASA or National Aeronautics and Space Administration
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Harish, K P; Mohana, K N; Mallesha, L
2014-01-01
A series of 2,5-disubstituted-1,3,4-thiadiazole derivatives were synthesized by the reaction of 3-(2-cyanopropan-2-yl)-N-(5-(piperazine-1-yl)-1,3,4-thiadiazol-2-yl)benzamide with various sulfonyl chlorides and evaluated for their anticonvulsant activity in MES test. Rotorod method was employed to determine the neurotoxicity. The purity of the compounds is confirmed on the basis of their elemental analysis. The structures of all the new compounds are established on the basis of 1H NMR and mass spectral data. Out of fifteen compounds, three were found to be potent anticolvunstants. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg).
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NASA Astrophysics Data System (ADS)
Reyes-Herrera, J.; Miranda, J.
2016-06-01
This study presents measurement results of x-ray production cross sections of Lα and Lβ1,3,4 emitted by four lanthanoid elements (La, Ce, Pr and Nd), after irradiation with Kα and Kβ X rays of the elements Co, Ni, Cu, and Zn (covering energies between 7.01 keV and 8.75 keV). Primary x-rays were induced in turn by the irradiation of thick targets of these elements with a beam of x-rays produced by a tube with an Rh anode, operating at 50 kV and 850 μA. The experimental results are compared with theoretical cross sections predicted using known tabulations of photoelectric cross sections. Dirac-Hartree-Slater (DHS) atomic parameters were used for these calculations. An acceptable match between experiment and both sets of tabulated data is found.
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STS-134 crew in Virtual Reality Lab during their MSS/EVAA SUPT2 Team training
2010-08-27
JSC2010-E-121045 (27 Aug. 2010) --- NASA astronaut Andrew Feustel (right), STS-134 mission specialist, uses the virtual reality lab in the Space Vehicle Mock-up Facility at NASA's Johnson Space Center to train for some of his duties aboard the space shuttle and space station. This type of computer interface, paired with virtual reality training hardware and software, helps to prepare crew members for dealing with space station elements. David Homan assisted Feustel. Photo credit: NASA or National Aeronautics and Space Administration
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Prasanna Kumar, Basavapatna N; Mohana, Kikkeri N; Mallesha, Lingappa; Harish, Kikkeri P
2013-01-01
A series of new 1,3,4-oxadiazole derivatives, 4(a-h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, (1)H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c, 4f, and 4g showed significant activity against tested strains.
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Method of locating a leaking fuel element in a fast breeder power reactor
Honekamp, John R.; Fryer, Richard M.
1978-01-01
Leaking fuel elements in a fast reactor are identified by measuring the ratio of .sup.134 Xe to .sup.133 Xe in the reactor cover gas following detection of a fuel element leak, this ratio being indicative of the power and burnup of the failed fuel element. This procedure can be used to identify leaking fuel elements in a power breeder reactor while continuing operation of the reactor since the ratio measured is that of the gases stored in the plenum of the failed fuel element. Thus, use of a cleanup system for the cover gas makes it possible to identify sequentially a multiplicity of leaking fuel elements without shutting the reactor down.
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NASA Astrophysics Data System (ADS)
Chandra, Sulekh; Gautam, Seema; Rajor, Hament Kumar; Bhatia, Rohit
2015-02-01
Novel Schiff's base ligand, benzil bis(5-amino-1,3,4-thiadiazole-2-thiol) was synthesized by the condensation of benzil and 5-amino-1,3,4-thiadiazole-2-thiol in 1:2 ratio. The structure of ligand was determined on the basis of elemental analyses, IR, 1H NMR, mass, and molecular modeling studies. Synthesized ligand behaved as tetradentate and coordinated to metal ion through sulfur atoms of thiol ring and nitrogen atoms of imine group. Ni(II), and Cu(II) complexes were synthesized with this nitrogen-sulfur donor (N2S2) ligand. Metal complexes were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic spectra, EPR, thermal, and molecular modeling studies. All the complexes showed molar conductance corresponding to non-electrolytic nature, expect [Ni(L)](NO3)2 complex, which was 1:2 electrolyte in nature. [Cu(L)(SO4)] complex may possessed square pyramidal geometry, [Ni(L)](NO3)2 complex tetrahedral and rest of the complexes six coordinated octahedral/tetragonal geometry. Newly synthesized ligand and its metal complexes were examined against the opportunistic pathogens. Results suggested that metal complexes were more biological sensitive than free ligand.
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Evaluation of two models for predicting elemental accumulation by arthropods
DOE Office of Scientific and Technical Information (OSTI.GOV)
Webster, J.R.; Crossley, D.A. Jr.
1978-06-15
Two different models have been proposed for predicting elemental accumulation by arthropods. Parameters of both models can be quantified from radioisotope elimination experiments. Our analysis of the 2 models shows that both predict identical elemental accumulation for a whole organism, though differing in the accumulation in body and gut. We quantified both models with experimental data from /sup 134/Cs and /sup 85/Sr elimination by crickets. Computer simulations of radioisotope accumulation were then compared with actual accumulation experiments. Neither model showed exact fit to the experimental data, though both showed the general pattern of elemental accumulation.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... WATER RESOURCES POLICIES AND AUTHORITIES: APPLICATION OF SECTION 134a OF PUBLIC LAW 94-587 § 276.2 Applicability. Policies and procedures contained herein apply to all elements and field operating agencies of the Corps of Engineers having Civil Works responsibilities. ...
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Prasanna Kumar, Basavapatna N.; Mohana, Kikkeri N.; Mallesha, Lingappa; Harish, Kikkeri P.
2013-01-01
A series of new 1,3,4-oxadiazole derivatives, 4(a–h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, 1H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds 4c, 4f, and 4g showed significant activity against tested strains. PMID:25374693
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Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety.
Frank, Priya V; Manjunatha Poojary, Mahesha; Damodara, Naral; Chikkanna, Chandrashekhar
2013-06-01
3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.
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1987-08-01
gate torsion is included in Part IV. The complete list of reports involved in the miter gate study can be found on page I of the preface. 17 . Before...Fig- ure 10. SM and CM results do not match. However, the pattern of distribution is similar; lower girders 17 and 18 carry high compression loads...118 (0.87) 142 (1.04) Girder 15 78 (0.57) 33 (0.24) Girder 16 -44 (-0.32) -30 (-0.22) Girder 17 -106 (-0.78) -147 (-1.08) Girder 18 -182 (-1.34) -134
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NASA Astrophysics Data System (ADS)
Qi, De-Qiang; Yu, Chuan-Ming; You, Jin-Zong; Yang, Guang-Hui; Wang, Xue-Jie; Zhang, Yi-Ping
2015-11-01
A series of pyrazole-based 1,3,4-oxadiazole derivatives were rationally designed and synthesized in good yields by following a convenient route. All the newly synthesized molecules were fully characterized by IR, 1H NMR and elemental analysis. Eight compounds were structurally determined by single crystal X-ray diffraction analysis. The fluorescence properties of all the compounds were investigated in dimethyl sulfoxide media. In addition, these newly synthesized compounds were evaluated for in vitro inhibitory activity against commercial enzyme xanthine oxidase (XO) by measuring the formation of uric acid from xanthine. Among the compounds synthesized and tested, 3d and 3e were found to be moderate inhibitory activity against commercial XO with IC50 = 72.4 μM and 75.6 μM. The studies gave a new insight in further optimization of pyrazole-based 1,3,4-oxadiazole derivatives with excellent fluorescence properties and XO inhibitory activity.
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1998-06-29
of some interstitial water during intercalation of the disulfide polymer of DMcT. Elemental analysis gives a composition for the intercalation...the disulfide polymer of DMcT. Elemental analysis gives a composition for the intercalation material of [(polyDMcT)o25*V205.4H20]. The cyclic...13.5 A). This change is consistent with loss of some interstitial water during intercalation of the disulfide polymer of DMcT. Elemental analysis
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Chandra, Sulekh; Gautam, Seema; Rajor, Hament Kumar; Bhatia, Rohit
2015-02-25
Novel Schiff's base ligand, benzil bis(5-amino-1,3,4-thiadiazole-2-thiol) was synthesized by the condensation of benzil and 5-amino-1,3,4-thiadiazole-2-thiol in 1:2 ratio. The structure of ligand was determined on the basis of elemental analyses, IR, (1)H NMR, mass, and molecular modeling studies. Synthesized ligand behaved as tetradentate and coordinated to metal ion through sulfur atoms of thiol ring and nitrogen atoms of imine group. Ni(II), and Cu(II) complexes were synthesized with this nitrogen-sulfur donor (N2S2) ligand. Metal complexes were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic spectra, EPR, thermal, and molecular modeling studies. All the complexes showed molar conductance corresponding to non-electrolytic nature, expect [Ni(L)](NO3)2 complex, which was 1:2 electrolyte in nature. [Cu(L)(SO4)] complex may possessed square pyramidal geometry, [Ni(L)](NO3)2 complex tetrahedral and rest of the complexes six coordinated octahedral/tetragonal geometry. Newly synthesized ligand and its metal complexes were examined against the opportunistic pathogens. Results suggested that metal complexes were more biological sensitive than free ligand. Copyright © 2014 Elsevier B.V. All rights reserved.
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2010-09-20
NEW ORLEANS -- The Space Shuttle Program's last external fuel tank, ET-122, is loaded onto the Pegasus Barge at NASA's Michoud Assembly Facility in New Orleans. The tank will travel 900 miles to NASA's Kennedy Space Center in Florida where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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Mohana, Kikkeri N.; Kumar, Chikkur B. Pradeep
2013-01-01
A series of new 5-(2-amino-5-methylthiazol-4-yl)-1,3,4-oxadiazole-2-thiol derivatives 6(a–j) were designed and synthesized with various substituted aldehydes. The chemical structures were confirmed by elemental analyses, FT-IR, 1H NMR, and mass spectral studies. The antioxidant activity of the synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, nitric oxide, and superoxide radical scavenging assay methods. Compounds 6a, 6e, and 6c showed significant radical scavenging potential due to the presence of electron donating substituent on substituted aldehydes. PMID:24052865
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Mohana, Kikkeri N; Kumar, Chikkur B Pradeep
2013-01-01
A series of new 5-(2-amino-5-methylthiazol-4-yl)-1,3,4-oxadiazole-2-thiol derivatives 6(a-j) were designed and synthesized with various substituted aldehydes. The chemical structures were confirmed by elemental analyses, FT-IR, (1)H NMR, and mass spectral studies. The antioxidant activity of the synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, nitric oxide, and superoxide radical scavenging assay methods. Compounds 6a, 6e, and 6c showed significant radical scavenging potential due to the presence of electron donating substituent on substituted aldehydes.
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W134: A new pre-main-sequence double-lined spectroscopic binary
NASA Technical Reports Server (NTRS)
Padgett, Deborah L.; Stapelfeldt, Karl R.
1994-01-01
We report the discovery that the pre-main-sequence star Walker 134 in the young cluster NGC 2264 is a double-lined spectroscopic binary. Both components are G stars with strong Li I 6708 A absorption lines. Twenty radial velocity measurements have been used to determined the orbital elements of this system. The orbit has a period of 6.3532 +/- 0.0012 days and is circular within the limits of our velocity resolution; e less than 0.01. The total system mass is stellar mass sin(exp 3) i = 3.16 solar mass with a mass ratio of 1.04. Estimates for the orbit inclination angle and stellar radii place the system near the threshold for eclipse observability; howerver, no decrease in brightness was seen during two attempts at photometric monitoring. The circular orbit of W 134 fills an important gap in the period distribution of pre-main-sequence binaries and thereby constrains the effectiveness of tidal orbital circularization during the pre-main sequence.
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2010-09-20
NEW ORLEANS -- Workers escort the Space Shuttle Program's last external fuel tank, ET-122, to the Pegasus Barge at NASA's Michoud Assembly Facility in New Orleans. The tank will travel 900 miles aboard the Pegasus Barge to NASA's Kennedy Space Center in Florida where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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Spectroscopic properties of 130Sb, 132Te and 134I nuclei in 100-132Sn magic cores
NASA Astrophysics Data System (ADS)
Benrachi, Fatima; Khiter, Meriem; Laouet, Nadjet
2017-09-01
We have performed shell model calculations by means of Oxbash nuclear structure code using recent experimental single particle (spes) and single hole (shes) energies with valence space models above the 100sn and 132sn doubly magic cores. The two-body matrix elements (tbme) of original CD-Bonn realistic interaction are introduced after have been modified taking into account the three-body forces. We have focused our study on spectroscopic properties evaluation of 130Sb, 132Te and 134I nuclei, in particular their energy spectra, transition probabilities and moments have been determined. The getting spectra are in reasonable agreement with the experimental data.
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Synthesis and spectral characterization of Zn(II) microsphere series for antimicrobial application
NASA Astrophysics Data System (ADS)
Singh, Ajay K.; Pandey, Sarvesh K.; Pandey, O. P.; Sengupta, S. K.
2014-09-01
Microsphere series have been synthesized by reacting zinc(II) acetate dihydrate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole/oxadiazole/triazole with salicylaldehyde. Elemental analysis suggests that the complexes have 1:2 and 1:1 stoichiometry of the type [Zn(L)2(H2O)2] and [Zn(L‧)(H2O)2]; LH = Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thia/oxadiazole with salicylaldehyde; L‧H2 = Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole and salicylaldehyde and were characterized by elemental analyses, IR, 1H NMR and 13C NMR spectral data. Scanning electron microscopy (SEM) showed that synthesized materials have microsphere like structure and there EDX analysis comparably matches with elemental analysis. For the antimicrobial application Schiff bases and their zinc(II) complexes were screened for four bacteria e.g. Bacillus subtilis, Pseudomonas aeruginosa, Salmonella typhi, Streptococcus pyogenes and four fungi e.g. Cyrtomium falcatum, Aspergillus niger, Fusarium oxysporium and Curvularia pallescence by the reported method. Schiff base and Zn(II) compounds showed significant antimicrobial activities. However, activities increase upon chelation. Thermal analysis (TGA) data of compound (10) showed its stability up to 300 °C.
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Pla, M; Vilardell, J; Guiltinan, M J; Marcotte, W R; Niogret, M F; Quatrano, R S; Pagès, M
1993-01-01
The maize gene rab28 has been identified as ABA-inducible in embryos and vegetative tissues. It is also induced by water stress in young leaves. The proximal promoter region contains the conserved cis-acting element CCACGTGG (ABRE) reported for ABA induction in other plant genes. Transient expression assays in rice protoplasts indicate that a 134 bp fragment (-194 to -60 containing the ABRE) fused to a truncated cauliflower mosaic virus promoter (35S) is sufficient to confer ABA-responsiveness upon the GUS reporter gene. Gel retardation experiments indicate that nuclear proteins from tissues in which the rab28 gene is expressed can interact specifically with this 134 bp DNA fragment. Nuclear protein extracts from embryo and water-stressed leaves generate specific complexes of different electrophoretic mobility which are stable in the presence of detergent and high salt. However, by DMS footprinting the same guanine-specific contacts with the ABRE in both the embryo and leaf binding activities were detected. These results indicate that the rab28 promoter sequence CCACGTGG is a functional ABA-responsive element, and suggest that distinct regulatory factors with apparent similar affinity for the ABRE sequence may be involved in the hormone action during embryo development and in vegetative tissues subjected to osmotic stress.
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Megally Abdo, Nadia Youssef; Kamel, Mona Monir
2015-01-01
A series of 5-(pyridin-4-yl)-N-substituted-1,3,4-oxadiazol-2-amines (3a-d), 5-(pyridin-4-yl)-N-substituted-1,3,4-thiadiazol-2-amines (4a-d) and 5-(pyridin-4-yl)-4-substituted-1,2,4-triazole-3-thiones (5a-d) were obtained by the cyclization of hydrazinecarbothioamide derivatives 2a-d derived from isonicotinic acid hydrazide. Aminoalkylation of compounds 5a-d with formaldehyde and various secondary amines furnished the Mannich bases 6a-p. The structures of the newly synthesized compounds were confirmed on the basis of their spectral data and elemental analyses. All the compounds were screened for their in vitro anticancer activity against six human cancer cell lines and normal fibroblast cells. Sixteen of the tested compounds exhibited significant cytotoxicity against most cell lines. Among these derivatives, the Mannich bases 6j, 6m and 6p were found to exhibit the most potent activity. The Mannich base 6m showed more potent cytotoxic activity against gastric cancer NUGC (IC50=0.021 µM) than the standard CHS 828 (IC50=0.025 µM). Normal fibroblast cells WI38 were affected to a much lesser extent (IC50>10 µM).
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Identification and Characterization of MYC Regulatory Elements: Links to Prostate Cancer
2011-06-01
cell proliferation and growth,MYC is up-regulated at both the mRNA and protein levels in aggressive prostate cancers ( DeMarzo et al. 2003). In...evolutionary synthesis: A genetic theory of morphological evolution. Cell 134: 25–36. DeMarzo AM, Nelson WG, Isaacs WB, Epstein JI. 2003. Pathological and
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2010-09-20
NEW ORLEANS -- Workers at NASA's Michoud Assembly Facility in New Orleans prepare the Space Shuttle Program's last external fuel tank, ET-122, for transportation to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea secured aboard the Pegasus Barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-21
NEW ORLEANS -- At NASA's Michoud Assembly Facility in New Orleans the Space Shuttle Program's last external fuel tank, ET-122, is ready for transportation to NASA's Kennedy Space Center in Florida. Secured aboard the Pegasus Barge the tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- The Space Shuttle Program's last external fuel tank, ET-122, moves from the Turn Basin to the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Once inside the Vehicle Assembly Building, it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-22
LOUISIANA -- In Gulfport, La., workers connect the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, to Freedom Star, NASA's solid rocket booster retrieval ship. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- The Space Shuttle Program's last external fuel tank, ET-122, moves from the Turn Basin to the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Once inside the Vehicle Assembly Building, it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-21
NEW ORLEANS -- A tug boat is pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- The Space Shuttle Program's last external fuel tank, ET-122, enters the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans to Kennedy's Turn Basin aboard the Pegasus Barge. The tank eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-20
NEW ORLEANS -- Workers escort the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans onto the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- The Space Shuttle Program's last external fuel tank, ET-122, moves from the Turn Basin to the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Once inside the Vehicle Assembly Building, it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-21
NEW ORLEANS -- A tug boat pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-20
NEW ORLEANS -- Workers escort the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans for transportation to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea secured aboard the Pegasus Barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- The Space Shuttle Program's last external fuel tank, ET-122, has been moved inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans to Kennedy's Turn Basin aboard the Pegasus Barge. The tank eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-28
CAPE CANAVERAL, Fla. -- The Space Shuttle Program's last external fuel tank, ET-122, moves into the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans to Kennedy's Turn Basin aboard the Pegasus Barge. The tank eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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Patel, Navin B; Patel, Jignesh N; Purohit, Amit C; Patel, Vatsal M; Rajani, Dhanji P; Moo-Puc, Rosa; Lopez-Cedillo, Julio Cesar; Nogueda-Torres, Benjamin; Rivera, Gildardo
2017-09-01
A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a-o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi. Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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Reactor-released radionuclides in Susquehanna River sediments
Olsen, C.R.; Larsen, I.L.; Cutshall, N.H.; Donoghue, J.F.; Bricker, O.P.; Simpson, H.J.
1981-01-01
Three Mile Island (TMI) and Peach Bottom (PB) reactors have introduced 137Cs, 134Cs, 60Co, 58Co and several other anthropogenic radionuclides into the lower Susquehanna River. Here we present the release history for these nuclides (Table 1) and radionuclide concentration data (Table 2) for sediment samples collected in the river and upper portions of the Chesapeake Bay (Fig. 1) within a few months after the 28 March 1979 loss-of-coolant-water problem at TMI. Although we found no evidence for nuclides characteristic of a ruptured fuel element, we did find nuclides characteristic of routine operations. Despite the TMI incident, more than 95% of the total 134Cs input to the Susquehanna has been a result of controlled low-level releases from the PB site. 134Cs activity released into the river is effectively trapped by sediments with the major zones of reactor-nuclide accumulation behind Conowingo Dam and in the upper portions of Chesapeake Bay. The reported distributions document the fate of reactor-released radionuclides and their extent of environmental contamination in the Susquehanna-Upper Chesapeake Bay System. ?? 1981 Nature Publishing Group.
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Power Spectra of Geomagnetic Fluctuations between 0.02 and 20 Hz
1981-12-01
BACKGROUND ----------------------------------------- 10 A. MAIN MAGNETIC FIELD ---------------------------- 10 B. ELEMENTS OF THE FIELD...Chew’s Ridge Sensor Orientation ------------------- 33 12. East-West Magnetic Field Fluctuations (.01-S Hz) 8/21/81, 1345 Hrs...36 13. East-West Magnetic Field Fluctuations (.1-10 H:) 8/21/81, 134S Hrs. -------------------------------- 37 14. East-West Magnetic Field
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Re-Imagining Democratic Citizenship Education: Towards a Culture of Compassionate Responsibility
ERIC Educational Resources Information Center
Davids, Nuraan; Waghid, Yusef
2012-01-01
Benhabib (2002:134) maintains that, in order for individuals to become democratic citizens they need to be exposed to at least three inter-related elements: collective identity, privileges of membership, and social rights and benefits. Through exposure to these three inter-related items it is hoped that, by means of the teaching and learning of…
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NASA Astrophysics Data System (ADS)
Singh, Ajay K.; Pandey, O. P.; Sengupta, S. K.
2013-09-01
Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL2(H2O)2](L = monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL2‧(OOCCH3)2(H2O)2](L‧ = neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, 1H NMR, and 13C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200 nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases.
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2010-09-27
CAPE CANAVERAL, Fla. -- The Pegasus Barge, carrying the Space Shuttle Program's last external fuel tank, ET-122, nears NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- A tugboat pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jim Grossmann
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, to the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, to the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-27
CAPE CANAVERAL, Fla. -- The Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, arrives at the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. Next, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-22
GULFPORT, La. -- At Gulfport, La., Michael Nicholas, captain M/V Freedom Star, guides NASA's solid rocket booster retrieval ship out of port pulling the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- NASA's Pegasus barge, carrying the Space Shuttle Program's last external fuel tank, ET-122, arrives at the Turn Basin of NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. Next, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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2010-09-25
CAPE CANAVERAL, Fla. -- This sunrise view from the stern of Freedom Star, one of NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-20
NEW ORLEANS -- To commemorate the history of the Space Shuttle Program's last external fuel tank, its intertank door is emblazoned with an ET-122 insignia. The external tank will travel 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans to NASA's Kennedy Space Center in Florida secured aboard the Pegasus Barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb., 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-26
CAPE CANAVERAL, Fla. -- Deckhands on Freedom Star, one of NASA's solid rocket booster retrieval ships, keep the ship in good repair as it pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- The Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, arrives at the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. Next, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-20
NEW ORLEANS -- Workers watch the progress of the Space Shuttle Program's last external fuel tank, ET-122, at NASA's Michoud Assembly Facility in New Orleans, as it is being loaded onto the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, to the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-21
NEW ORLEANS -- At NASA's Michoud Assembly Facility in New Orleans a tug boat is prepared to escort the Space Shuttle Program's last external fuel tank, ET-122, for transportation to NASA's Kennedy Space Center in Florida. Secured aboard the Pegasus Barge the tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-20
NEW ORLEANS -- Workers check the progress of the Space Shuttle Program's last external fuel tank, ET-122, at NASA's Michoud Assembly Facility in New Orleans as it is being loaded onto the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, the Pegasus Barge, carrying the Space Shuttle Program's last external fuel tank, ET-122, arrives at the Turn Basin. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-26
CAPE CANAVERAL, Fla. -- This view is from the deck of Freedom Star, one of NASA's solid rocket booster retrieval ships, as it pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-22
CAPE CANAVERAL, Fla. -- This view from Freedom Star, one NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, as it is transported to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-26
CAPE CANAVERAL, Fla. -- This view from the stern of Freedom Star, one of NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-26
CAPE CANAVERAL, Fla. -- Deckhands on Freedom Star, one of NASA's solid rocket booster retrieval ships, keep the ship in good repair as it pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-22
CAPE CANAVERAL, Fla. -- This view from the stern of Freedom Star, one of NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, as it is transported to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea, offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- A tugboat pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. Next, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-28
CAPE CANAVERAL, Fla. -- This overhead view shows the Space Shuttle Program's last external fuel tank, ET-122, as it is being transported to the Vehicle Assembly Building (VAB) at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea, carried in the Pegasus Barge, from NASA's Michoud Assembly Facility in New Orleans. Once inside the VAB, it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station targeted to launch Feb. 2011. STS-134 currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kevin O'Connell
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb., 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-25
CAPE CANAVERAL, Fla. -- This view from the stern of Freedom Star, one of NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-26
CAPE CANAVERAL, Fla. -- A deckhand on Freedom Star, one of NASA's solid rocket booster retrieval ships, keeps the ship in good repair as it pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb., 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-27
CAPE CANAVERAL, Fla. -- A tug boat pulls the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. Next, the tank will be offloaded and moved to Kennedy's Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-26
CAPE CANAVERAL, Fla. -- Deckhands on Freedom Star, one of NASA's solid rocket booster retrieval ships, keep the ship in good repair as it pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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NASA Astrophysics Data System (ADS)
Gautam, P.; Gautam, D.; Chaudhary, R. P.
2013-12-01
The title compound N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide ( III) was obtained from the reaction of 2-(propan-2-ylidene)hydrazinecarbothioamide ( II) with acetic anhydride instead of formation of the desired thiosemcarbazide derivative of Meldrum acid. The structures of II and III were established by elemental analysis, IR, NMR, Mass and X-ray crystallographic studies. II crystallizes in triclinic system, sp. gr. Z = 2; III crystallizes in the monoclinic system, sp. gr. P21/ c, Z = 8. Density functional theory (DFT) calculations have been carried out for III. 1H and 13C NMR of III has been calculated and correlated with experimental results.
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2010-09-20
NEW ORLEANS -- Workers monitor the progress of the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans as it is being loaded onto the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-20
NEW ORLEANS -- Workers monitor the progress of the Space Shuttle Program's last external fuel tank, ET-122, at NASA's Michoud Assembly Facility in New Orleans as it is being loaded onto the Pegasus BargeThe tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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NASA Astrophysics Data System (ADS)
Shuxia, ZHAO; Lei, ZHANG; Jiajia, HOU; Yang, ZHAO; Wangbao, YIN; Weiguang, MA; Lei, DONG; Liantuan, XIAO; Suotang, JIA
2018-03-01
The chemical composition of alloys directly determines their mechanical behaviors and application fields. Accurate and rapid analysis of both major and minor elements in alloys plays a key role in metallurgy quality control and material classification processes. A quantitative calibration-free laser-induced breakdown spectroscopy (CF-LIBS) analysis method, which carries out combined correction of plasma temperature and spectral intensity by using a second-order iterative algorithm and two boundary standard samples, is proposed to realize accurate composition measurements. Experimental results show that, compared to conventional CF-LIBS analysis, the relative errors for major elements Cu and Zn and minor element Pb in the copper-lead alloys has been reduced from 12%, 26% and 32% to 1.8%, 2.7% and 13.4%, respectively. The measurement accuracy for all elements has been improved substantially.
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Shen, Jun; Xu, Linling; Qu, Chujie; Sun, Huimin; Zhang, Junjian
2018-04-30
Chronic unpredictable mild stress (CUMS) leads to neuropsychiatric disorders, such as depression, anxiety and cognitive impairment. Resveratrol is a natural polyphenol existed in polygonum cuspidatum and has been demonstrated to be a potent activator of Sirtuin 1 (Sirt1). Previous studies reported that resveratrol treatment ameliorated CUMS-induced depressive-like behavior and cognitive deficits through upregulating cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) expression. However, the upstream signalling pathway mediating CREB/BDNF expression and then exerting a protective role on cognitive function remains unclear. The present study aims to investigate the possible mechanism of resveratrol on CUMS-induced cognitive deficits. Male Sprague Dawley rats were adminstrated resveratrol (40 and 80 mg/kg) every day for 4 consecutive weeks before exposure to CUMS procedure. Morris Water Maze test was used to appraise spatial learing and memory of rats. Sirt1/miR-134 signalling pathway and CREB/BDNF expression in hippocampus of rats were measured. We also explored Sirt1/miR-134 signalling pathway and CREB/BDNF expression in primary cultured hippocampus neurons with resveratrol (25, 50 and 100 μmol/L) treatment. We found that resveratrol treatment prevented spatial learing and memory impairment induced by CUMS. Meanwhile the potential mechanism of resveratrol was associated with increased levels of Sirt1, CREB phosphorylation (p-CREB), CREB, BDNF and decreased levels of miR-134 in vivo and in vitro. In conclusion, our study showed that the neuroprotective effect of resveratrol on CUMS-induced cognitive impairment may rely on activating Sirt1/miR-134 pathway and then upregulating its downstream CREB/BDNF expression in hippocampus. Copyright © 2018 Elsevier B.V. All rights reserved.
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Singh, Ajay K; Pandey, O P; Sengupta, S K
2013-09-01
Zn(II) complexes have been synthesized by reacting zinc acetate with Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/benzaldehyde/indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non electrolytes. Elemental analyses suggest that the complexes have 1:2 metal to ligands stoichiometry of the types [ZnL2(H2O)2](L=monoanionic Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and 2-hydroxyacetophenone/indoline-2,3-dione) [ZnL2(')(OOCCH3)2(H2O)2](L'=neutral Schiff bases derived from 2-hydrazino-5-[substituted phenyl]-1,3,4-thiadiazole and benzaldehyde), and they were characterized by IR, (1)H NMR, and (13)C NMR. Particle sizes of synthesized compounds were measured with dynamic light scattering (DLS) analyser which indicates that particle diameter are of the range ca. 100-200nm. All these Schiff bases and their complexes have also been screened for their antibacterial (Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and antifungal activities (Colletotrichum falcatum (C. falcatum), Aspergillus niger (A. niger), Fusarium oxysporium (F. oxysporium) Curvularia pallescence (C. pallescence). The antimicrobial activities have shown that upon complexation the activity increases. Copyright © 2013 Elsevier B.V. All rights reserved.
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Botti, Lorenzo; Paliwal, Nikhil; Conti, Pierangelo; Antiga, Luca; Meng, Hui
2018-06-01
Image-based computational fluid dynamics (CFD) has shown potential to aid in the clinical management of intracranial aneurysms (IAs) but its adoption in the clinical practice has been missing, partially due to lack of accuracy assessment and sensitivity analysis. To numerically solve the flow-governing equations CFD solvers generally rely on two spatial discretization schemes: Finite Volume (FV) and Finite Element (FE). Since increasingly accurate numerical solutions are obtained by different means, accuracies and computational costs of FV and FE formulations cannot be compared directly. To this end, in this study we benchmark two representative CFD solvers in simulating flow in a patient-specific IA model: (1) ANSYS Fluent, a commercial FV-based solver and (2) VMTKLab multidGetto, a discontinuous Galerkin (dG) FE-based solver. The FV solver's accuracy is improved by increasing the spatial mesh resolution (134k, 1.1m, 8.6m and 68.5m tetrahedral element meshes). The dGFE solver accuracy is increased by increasing the degree of polynomials (first, second, third and fourth degree) on the base 134k tetrahedral element mesh. Solutions from best FV and dGFE approximations are used as baseline for error quantification. On average, velocity errors for second-best approximations are approximately 1cm/s for a [0,125]cm/s velocity magnitude field. Results show that high-order dGFE provide better accuracy per degree of freedom but worse accuracy per Jacobian non-zero entry as compared to FV. Cross-comparison of velocity errors demonstrates asymptotic convergence of both solvers to the same numerical solution. Nevertheless, the discrepancy between under-resolved velocity fields suggests that mesh independence is reached following different paths. This article is protected by copyright. All rights reserved.
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, pulls the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, pulls the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, pulls the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, ushers the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, pulls the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- NASA's Pegasus barge moves through the bridge at Port Canaveral, Fla. The barge is carrying the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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2010-09-22
CAPE CANAVERAL, Fla. -- This view at dusk from the stern of Freedom Star, one of NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, as it is transported to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, ushers the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-22
GULFPORT, La. -- This view from the captain's deck of Freedom Star, one of NASA's solid rocket booster retrieval ships, shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, as it is escorted from Gulfport, La., to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- NASA's Pegasus barge is pulled toward NASA's Kennedy Space Center in Florida by a tug boat. The barge is carrying the Space Shuttle Program's last external fuel tank, ET-122 and traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Kim Shiflett
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2010-09-27
CAPE CANAVERAL, Fla. -- Freedom Star, one of NASA's solid rocket booster retrieval ships, pulls the Space Shuttle Program's last external fuel tank, ET-122, toward NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. After reaching the Turn Basin at Kennedy, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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Computer-Aided Design for Built-In-Test (CADBIT) - Software Specification. Volume 3
1989-10-01
CADD COMAN WIDO IO-CNURET MSL PPLYING~ TET ATEN Figur 3-13- TUTORIA FIGUR PLCMI IN CAD-NVIOMENT ON BOAR SEFTST- 1"os-rnenu, long-tur d nnnih que- list...have software package for reliability calculation A-8 LIBRARY ELEMENT DATA SHE T’" BIT TECHNIQUE: ON-BOARD ROM CATEGORY: L’ONG TUTORIA PAGE ,5 of 14
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Trade Group Rules Against China in Rare Earths Dispute
NASA Astrophysics Data System (ADS)
Showstack, Randy
2014-04-01
The World Trade Organization (WTO) has ruled against China in a trade dispute over rare earth elements (REE) as well as tungsten and molybdenum, the group announced on 26 March. The European Union, Japan, and the United States brought trade cases against China in March 2012 concerning alleged unfair export restraints on the materials (see Eos, 93(13), 134-135, doi:10.1029/2012EO130002).
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Research Policy in the Federal Republic of Germany.
1980-12-16
particularly for coal use, flue gas decontamination (particularly for desulfurization ), sewage treatment, biological pest control , and artificial fertilizers...NAME AND AODRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA 8 WORK UNIT NUMBERS 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE 16 December 198 0...34 1" NUMSER-OF PAGES 14. MONITORING AGENCY NAME & ADDRESS(If different fromt Controlling Office) 15. SECURITY CLASS. (o this repol) Unclassified
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Mineral composition of Atriplex hymenelytra growing in the northern Mojave Desert
DOE Office of Scientific and Technical Information (OSTI.GOV)
Wallace, A.; Romney, E.M.; Hunter, R.B.
1980-01-01
Fifty samples of Atriplex hymenelytra (Torr.) S. Wats. were collected from several different locations in southern Nevada and California to test variability in mineral composition. Only Na, V, P, Ca, Mg, Mn, and Sr in the samples appeared to represent a uniform population resulting in normal curves for frequency distribution. Even so, about 40 percent of the variance for these elements was due to location. All elements differed enough with location so that no element really represented a uniform population. The coefficient of variation for most elements was over 40 percent and one was over 100 percent. The proportion ofmore » variance due to analytical variation averaged 16.2 +- 13.1 percent (standard deviation), that due to location was 43.0 +- 13.4 percent, and that due to variation of plants within location was 40.7 +- 13.0 percent.« less
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How high is visual short-term memory capacity for object layout?
Sanocki, Thomas; Sellers, Eric; Mittelstadt, Jeff; Sulman, Noah
2010-05-01
Previous research measuring visual short-term memory (VSTM) suggests that the capacity for representing the layout of objects is fairly high. In four experiments, we further explored the capacity of VSTM for layout of objects, using the change detection method. In Experiment 1, participants retained most of the elements in displays of 4 to 8 elements. In Experiments 2 and 3, with up to 20 elements, participants retained many of them, reaching a capacity of 13.4 stimulus elements. In Experiment 4, participants retained much of a complex naturalistic scene. In most cases, increasing display size caused only modest reductions in performance, consistent with the idea of configural, variable-resolution grouping. The results indicate that participants can retain a substantial amount of scene layout information (objects and locations) in short-term memory. We propose that this is a case of remote visual understanding, where observers' ability to integrate information from a scene is paramount.
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Maximum Grasping Reach of Operators Possessing Functional Impairments of the Upper Extremities.
1978-12-01
ADDRESS 10. PROGRAM ELEMENT, PROJECT, TASK AFITStudent at: Texas A&M University AREA & WORK UNIT NUMBERS II. CONTROLLING OFFICENA E AND AD_. . 12...RELEASE AFR 190.172 Ja e I 10, t USAF 23 SEP 1980 , ’ 1"lic Aar* e IS. SUPPLEMENTARY NOTES Approved for public release; IAW AFR 190-17 Air Force...C .. .... ..... ..... .... 141 APPENDIX D .. ... ...... ..... .... 184 APPENDIX E .. ... ..... ...... .... 187 APPENDIX F .. .... ..... ..... .... 189
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Mathematical Techniques for Nonlinear System Theory.
1978-01-01
4. TITLE (and Subtitle) 5. TYPE OF REPORT 6 PERIOD COVERED MATHEMATICAL TECHNIQUES FOR NONLINEAR SYSTEM THEORY Interim 6...ADDRESS 10. PROGRAM ELEMENT. PROJECT . TASK AREA & WORK UNIT NUMBERS Unlvers].ty of Flori.da Center for Mathematical System Theory ~~~~ Gainesville , FL...rings”, Mathematical System Theory , 9: 327—344. E. D. SONTAG (1976b1 “Linear systems over commutative rings: a survey”, Richerche di Automatica, 7: 1-34
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Sakama, M., E-mail: minorusakama@tokushima-u.ac.jp; Nagano, Y.; Kitade, T.
2014-06-15
Radioactive fission product {sup 131}I released from the Fukushima Daiichi Nuclear Power Plants (FD-NPP) was first detected on March 23, 2011 in an airborne aerosol sample collected at Tokushima, Shikoku Island, located in western Japan. Two other radioactive fission products, {sup 134}Cs and {sup 137}Cs were also observed in a sample collected from April 2 to 4, 2011. The maximum specific radioactivities observed in this work were about 2.5 to 3.5 mBq×m{sup -3} in a airborne aerosol sample collected on April 6. During the course of the continuous monitoring, we also made our first observation of seasonal Asian Dust andmore » those fission products associated with the FDNPP accident concurrently from May 2 to 5, 2011. We found that the specific radioactivities of {sup 134}Cs and {sup 137}Cs decreased drastically only during the period of Asian Dust. And also, it was found that this trend was very similar to the atmospheric elemental concentration (ng×m{sup -3}) variation of stable cesium ({sup 133}Cs) quantified by elemental analyses using our developed ICP-DRC-MS instrument.« less
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Long-range activation of Sox9 in Odd Sex (Ods) mice.
Qin, Yangjun; Kong, Ling-kun; Poirier, Christophe; Truong, Cavatina; Overbeek, Paul A; Bishop, Colin E
2004-06-15
The Odd Sex mouse mutation arose in a transgenic line of mice carrying a tyrosinase minigene driven by the dopachrome tautomerase (Dct) promoter region. The minigene integrated 0.98 Mb upstream of Sox9 and was accompanied by a deletion of 134 kb. This mutation causes female to male sex reversal in XX Ods/+ mice, and a characteristic eye phenotype of microphthalmia with cataracts in all mice carrying the transgene. Ods causes sex reversal in the absence of Sry by upregulating Sox9 expression and maintaining a male pattern of Sox9 expression in XX Ods/+ embryonic gonads. This expression, which begins at E11.5, triggers downstream events leading to the formation of a testis. We report here that the 134 kb deletion, in itself, is insufficient to cause sex reversal. We demonstrate that in Ods, the Dct promoter is capable of acting over a distance of 1 Mb to induce inappropriate expression of Sox9 in the retinal pigmented epithelium of the eye, causing the observed microphthalmia. In addition, it induces Sox9 expression in the melanocytes where it causes pigmentation defects. We propose that Ods sex reversal is due to the Dct promoter element interacting with gonad-specific enhancer elements to produce the observed male pattern expression of Sox9 in the embryonic gonads.
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2010-09-20
NEW ORLEANS -- Associate Administrator for Space Operations Bill Gerstenmaier and Manny Zulueta, Lockheed Martin vice president and site executive at NASA's Michoud Assembly Facility in New Orleans, discuss the progress of the Space Shuttle Program's last external fuel tank, ET-122, as it is being transported from the facility to the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida, secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- To commemorate the history of the Space Shuttle Program's last external fuel tank, its intertank door is emblazoned with an ET-122 insignia. The tank is in the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida after traveling 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. It eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was completed in 2002, modified during Return to Flight operations in 2003 and 2004, damaged during Hurricane Katrina in 2005, and then restored to flight configuration by Lockheed Martin Space Systems Company employees in 2008 at NASA's Marshall Space Flight Center in Alabama. Photo credit: NASA/Jack Pfaller
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2010-09-28
CAPE CANAVERAL, Fla. -- This panoramic image shows the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, through the Port Canaveral locks on its way to the Turn Basin at NASA's Kennedy Space Center in Florida. Once docked, the tank will be offloaded from the barge and transported to the Vehicle Assembly Building (VAB). The tank traveled 900 miles by sea, carried in the barge, from NASA's Michoud Assembly Facility in New Orleans. Once inside the VAB, it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station targeted to launch Feb. 2011. STS-134 currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Frankie Martin
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2010-09-27
CAPE CANAVERAL, Fla. -- A tugboat pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, toward the Turn Basin at NASA's Kennedy Space Center in Florida. The tank traveled 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans. In the background, space shuttle Discovery is on Launch Pad 39A awaiting liftoff on the STS-133 mission to the International Space Station. Next, the tank will be offloaded and moved to the Vehicle Assembly Building where it eventually will be attached to space shuttle Endeavour for the STS-134 mission to the station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. Photo credit: NASA/Jack Pfaller
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2010-09-20
NEW ORLEANS -- Associate Administrator for Space Operations Bill Gerstenmaier and Manny Zulueta, Lockheed Martin vice president and site executive at NASA's Michoud Assembly Facility in New Orleans, watch the progress of the Space Shuttle Program's last external fuel tank, ET-122, as it is being transported from the facility to the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-22
LOUISIANA -- A tug boat pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans toward a dock in Gulfport, La. The barge will meet up with Freedom Star, NASA's solid rocket booster retrieval ship, which will escort it to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-20
NEW ORLEANS -- At NASA's Michoud Assembly Facility in New Orleans, Associate Administrator for Space Operations Bill Gerstenmaier and a Michoud employee discuss the progress of the Space Shuttle Program's last external fuel tank, ET-122, as it is being transported from the facility to the Pegasus Barge. The tank will travel 900 miles by sea to NASA's Kennedy Space Center in Florida secured aboard the barge, offloaded and moved to Kennedy's Vehicle Assembly Building where it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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2010-09-28
CAPE CANAVERAL, Fla. -- To commemorate the history of the Space Shuttle Program's last external fuel tank, its intertank door is emblazoned with an ET-122 insignia. The tank is in the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida after traveling 900 miles by sea from NASA's Michoud Assembly Facility in New Orleans aboard the Pegasus Barge. It eventually will be attached to space shuttle Endeavour for the STS-134 mission to the International Space Station. STS-134, targeted to launch in Feb. 2011, currently is scheduled to be the last mission in the shuttle program. The tank, which is the largest element of the space shuttle stack, was completed in 2002, modified during Return to Flight operations in 2003 and 2004, damaged during Hurricane Katrina in 2005, and then restored to flight configuration by Lockheed Martin Space Systems Company employees in 2008 at NASA's Marshall Space Flight Center in Alabama. Photo credit: NASA/Jack Pfaller
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2010-09-22
LOUISIANA -- A tug boat pulls the Pegasus Barge carrying the Space Shuttle Program's last external fuel tank, ET-122, from NASA's Michoud Assembly Facility in New Orleans toward Gulfport, La. The barge will meet up with Freedom Star, NASA's solid rocket booster retrieval ship, which will escort it to NASA's Kennedy Space Center in Florida. The tank will travel 900 miles by sea before being offloaded and moved to Kennedy's Vehicle Assembly Building. There it will be integrated to space shuttle Endeavour for the STS-134 mission to the International Space Station. The tank, which is the largest element of the space shuttle stack, was damaged during Hurricane Katrina in August 2005 and restored to flight configuration by Lockheed Martin Space Systems Company employees. STS-134, targeted to launch Feb. 2011, currently is scheduled to be the last mission in the Space Shuttle Program. Photo credit: NASA/Kim Shiflett
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Kostyuchenko, Anastasia S; L.Yurpalov, Vyacheslav; Kurowska, Aleksandra; Domagala, Wojciech; Pron, Adam
2014-01-01
Summary A new synthetic approach towards the preparation of functionalised, soluble, donor–acceptor (DA) alkylbithiophene derivatives of oxadiazole, thiadiazole and triazole is reported. Taking advantage of the Fiesselmann reaction, reactive bithiophene synthons having alkyl or alkoxy substituents at designated positions are prepared. Following a synthetic strategy, featuring the bottom-up approach, sequential structural elements are built, starting from a simple thiophene compound, until the target molecule is obtained, all in good yield. Supplementing the well established methods of oxadiazole and thiadiazole synthesis, efficient ring closure reaction affording a 4H-1,2,4-triazole unit is presented. All target ambipolar compounds display strong photoluminescence with measured quantum yields up to 0.59. Modification of the demonstrated synthetic routes may be exploited for the preparation of longer, specifically functionalised oligothiophenes, coupled to other heteroaromatic cores. PMID:25161716
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Kostyuchenko, Anastasia S; L Yurpalov, Vyacheslav; Kurowska, Aleksandra; Domagala, Wojciech; Pron, Adam; Fisyuk, Alexander S
2014-01-01
A new synthetic approach towards the preparation of functionalised, soluble, donor-acceptor (DA) alkylbithiophene derivatives of oxadiazole, thiadiazole and triazole is reported. Taking advantage of the Fiesselmann reaction, reactive bithiophene synthons having alkyl or alkoxy substituents at designated positions are prepared. Following a synthetic strategy, featuring the bottom-up approach, sequential structural elements are built, starting from a simple thiophene compound, until the target molecule is obtained, all in good yield. Supplementing the well established methods of oxadiazole and thiadiazole synthesis, efficient ring closure reaction affording a 4H-1,2,4-triazole unit is presented. All target ambipolar compounds display strong photoluminescence with measured quantum yields up to 0.59. Modification of the demonstrated synthetic routes may be exploited for the preparation of longer, specifically functionalised oligothiophenes, coupled to other heteroaromatic cores.
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NASA Astrophysics Data System (ADS)
Kumar Naik, K. H.; Ashok, B.; Naik, Nagaraja; Mulla, Jameel Ahmed S.; Prakasha, Avinash
2015-04-01
Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i-ii) have been synthesized. The newly synthesized ligands and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies [infrared (IR), electronic, and NMR (for ligands only)]. Metal complexes are like [M(AMTA)2], [M(ATA)2] type, where M = Mn(II), Co(II) and Cu(II). The proposed geometries of the complexes are octahedral in nature. The synthesized ligands and their complexes were exhibits effective anti-inflammatory, analgesic and DNA binding activities. All the tested compounds exhibited significant analgesic activity, whereas the compound 4i, 4(ia) and 4(iib) is equipotent with Diclofenac sodium.
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Wei, Shuhe; Anders, Iwona; Feller, Urs
2014-06-01
The focus of this article was to explore the translocation of (109)Cd, (57)Co, (65)Zn, (63)Ni, and (134)Cs via xylem and phloem in the newly found hyperaccumulator Solanum nigrum L. Two experiments with the uptake via the roots and transport of (109)Cd, (57)Co, and (65)Zn labeled by roots, and the redistribution of (109)Cd, (65)Zn, (57)Co, (63)Ni, and (134)Cs using flap label in S. nigrum in a hydroponic culture with a standard nutrient solution were conducted. The results showed that (109)Cd added for 24 h to the nutrient medium of young plants was rapidly taken up, transferred to the shoot, and accumulated in the cotyledons and the oldest leaves but was not efficiently redistributed within the shoot afterward leading to a rather low content in the fruits. In contrast, (57)Co was more slowly taken up and released to the shoot, but afterward, this element was redistributed from older leaves to younger leaves and maturing fruits. (65)Zn was rapidly taken up and transferred to the shoot (mainly to the youngest leaves and not to the cotyledons). Afterward, this radionuclide was redistributed within the shoot to the youngest organs and finally accumulated in the maturing fruits. After flap labeling, all five heavy metals tested ((109)Cd, (57)Co, (65)Zn, (63)Ni, (134)Cs) were exported from the labeled leaf and redistributed within the plant. The accumulation in the fruits was most pronounced for (63)Ni and (65)Zn, while a relatively high percentage of (57)Co was finally found in the roots. (134)Cs was roughly in the middle of them. The transport of (109)Cd differed from that previously reported for wheat or lupin and might be important for the potential of S. nigrum to hyperaccumulate cadmium.
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Li, Yuhao; Zhu, Hongjun; Chen, Kai; Liu, Rui; Khallaf, Abdalla; Zhang, Xiangning; Ni, Jueping
2013-06-28
A series of anthranilic diamides analogs (3–11, 16–24) containing 1,2,4- or 1,3,4-oxadiazole rings were synthesized and characterized by (1)H NMR, MS and elemental analyses. The structure of 3-bromo-N-(2-(3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (18, CCDC-) was determined by X-ray diffraction crystallography. The insecticidal activities against Plutella xylostella and Spodoptera exigua were evaluated. The results showed that most of title compounds displayed good larvicidal activities against P. xylostella, especially compound 3-bromo-N-(4-chloro-2-methyl-6-(5-(methylthio)-1,3,4-oxadiazol-2-yl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (6), which displayed 71.43% activity against P. xylostella at 0.4 μg mL(-1) and 33.33% against S. exigua at 1 μg mL(-1). The structure-activity relationship showed that compounds decorated with a 1,3,4-oxadiazole were more potent than compounds decorated with a 1,2,4-oxadiazole, and different substituents attached to the oxadiazole ring also affected the insecticidal activity. This work provides some hints for further structure modification and the enhancement of insecticidal activity.
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NASA Astrophysics Data System (ADS)
Castiñeiras, Alfonso; García-Santos, Isabel; Nogueiras, Silvia; Rodríguez-González, Iria; Rodríguez-Riobó, Raúl
2014-09-01
Reaction of 2-cyanopyrazine with thiosemicarbazide or N-methylthiosemicarbazide afforded the (Z)-2-(amino(pyrazin-2-yl)methylene)hydrazinecarbothioamide (HPzAm4DH) and (Z)-2-(amino(pyrazin-2-yl)methylene)-N-methylhydrazine carbothioamide (HPzAm4M), respectively. (2Z,N‧E)-N‧-(4-Oxothiazolidin-2-ylidene)pyrazine-2-carbohydrazonamide (HPzAmot, 5) and (2Z,N‧E)-N‧-(3-methyl-4-oxothiazolidin-2-ylidene)pyrazine-2-carbohydrazonamide (MPzAmot, 7) have been synthesized from these thiosemicarbazones with chloroacetic or bromoacetic acids, using a conventional synthetic methodology and microwave-assisted organic reaction enhancement. The crystal structures of the thiosemicarbazones and their solvates [HPzAm4DHṡ1/2 MeOH (1), HPzAm4DHṡH2O (2), HPzAm4M (3), HPzAm4Mṡ2H2O (4)] and the 1,3-thiazolidin-4-ones (5 and 7) have been studied by X-ray diffractometry. All of the compounds were characterized by elemental analysis, mass spectrometry, FT-IR and 1H and 13C NMR spectroscopy. Several by-products have also been isolated in a crystalline form, namely 3-((Z,E)-N‧-(4-oxothiazolidin-2-ylidene)carbamohydrazonium-yl)pyrazin-1-ium dibromide monohydrate, (H3PzAmot)Br2ṡH2O (6), 2-((5-(pyrazin-2-yl)-1H-1,2,4-triazol-3-yl)thio)acetic acid, (H2Pz124ttAc) (8), 2-amino-5-(pyrazin-2-yl)-1,3,4-thiadiazol-3-ium chloride monohydrate, (HPz134tda)ClṡH2O (9), and 2-(methylamino)-5-(pyrazin-2-yl)-1,3,4-thiadiazol-3-ium chloride N-methyl-5-(pyrazin-2-yl)-1,3,4-thiadiazol-2-amine solvate, (HMPz134tda)Clṡ(MPz134tda) (10). The structures of these compounds were also analyzed by X-ray diffractometry. The microwave-assisted organic reaction method for synthesis is easy, convenient, and ecofriendly when compared to the traditional synthetic methods. Crystal analysis revealed that the compounds have extended 3D supramolecular networks through high levels of H-bonding and weak molecular interactions between the molecular moieties and solvent molecules. The novel synthons, which are sustained by Nsbnd H⋯N and Nsbnd H⋯O hydrogen bonding and other weak interactions, have been shown to assemble with 1,3-thizolidine-4-ones, 1,2,4-trizole, or 1,3,4-thiadiazole derivatives in a zigzag or herringbone architecture.
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Measuring Morale within the French Army
2006-04-01
Measuring Morale within the French Army 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...RTO-MP-HFM-134 29 - 1 Measuring Morale within the French Army Commandant Jean Michel FORET EMAT/Centre de Relations Humaines 14 rue Saint...Dominique 00453 Armées FRANCE crh.emat@emat.terre.defense.gouv.fr ABSTRACT The evaluation of the operational capabilitity of the Army passes by
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Bilandžić, Nina; Dežđek, Danko; Sedak, Marija; Dokić, Maja; Solomun, Božica; Varenina, Ivana; Knežević, Zorka; Slavica, Alen
2010-11-01
Trace elements concentrations (As, Cd, Cu, Pb and Hg) were determined in the liver, kidney and muscle of 28 red fox (Vulpes vulpes) and 16 stone marten (Martes foina) from suburban and rural habitats from Croatia. Rural and suburban habitats affected Cd and Hg levels in the muscle, liver and kidney of red fox. Significant differences in metal concentrations in the muscle, liver and kidney were detected among species. Suburban stone marten accumulated the highest levels of trace elements (mg/kg w.w.): in muscle 0.019 for Hg; in liver 0.161 for Cd, 36.1 for Cu and 0.349 for Pb; in kidney 1.34 for Cd and 0.318 for Pb. Values observed were higher than those found in suburban red fox and therefore, may represent an important bioindicator for the accumulation of toxic metals in urbanized habitats.
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NASA Astrophysics Data System (ADS)
Khezri, Somayeh; Bahram, Morteza; Samadi, Naser
2018-01-01
In this paper, we describe a rapid, low-cost and highly sensitive colorimetric method for the detection of isoprenaline, based on 2-amino-5-mercapto-1,3,4-thiadiazol (AMTD) functionalized gold nanoparticles (AMTD-AuNPs) as a sensing element. Hydrogen bonding interaction between isoprenaline and AMTD resulted in the aggregation of AuNPs and a consequent color change of AuNPs from red to blue. The concentration of isoprenaline could be detected with the naked eye or a UV-visible spectrometer. Results showed that the absorbance ratio (A650/A524) was linear with isoprenaline concentrations in the range of 0.2 to 2.6 μM (R = 0.997). The detection limit of this method was 0.08 μM. The proposed method is simple, without using complicated instruments and adding salts for enhancing sensitivity. This probe could be successfully applied to the determination of isoprenaline in human serum samples and urine samples after deproteinization.
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Harish, Kikkeri P; Mohana, Kikkeri N; Mallesha, Lingappa; Prasanna Kumar, Basavapatna N
2013-07-01
A series of novel 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-piperazine derivatives 8(a-o) were synthesized and characterized by elemental analyses, (1)H NMR, (13)C NMR and mass spectral studies. The newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock seizure (MES) model in male wistar rats and compared with the standard drug phenytoin. The neurotoxic effects were determined by rotorod test by using mice. Compounds 8d, 8e, 8f and 8h were found to be most potent of this series. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg). The efforts were also made to establish the structure activity relationships among synthesized compounds. The pharmacophore model was used to validate the anticonvulsant activity of the synthesized molecules. Copyright © 2013 Elsevier Masson SAS. All rights reserved.
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Hydrogen-based electrochemical energy storage
Simpson, Lin Jay
2013-08-06
An energy storage device (100) providing high storage densities via hydrogen storage. The device (100) includes a counter electrode (110), a storage electrode (130), and an ion conducting membrane (120) positioned between the counter electrode (110) and the storage electrode (130). The counter electrode (110) is formed of one or more materials with an affinity for hydrogen and includes an exchange matrix for elements/materials selected from the non-noble materials that have an affinity for hydrogen. The storage electrode (130) is loaded with hydrogen such as atomic or mono-hydrogen that is adsorbed by a hydrogen storage material such that the hydrogen (132, 134) may be stored with low chemical bonding. The hydrogen storage material is typically formed of a lightweight material such as carbon or boron with a network of passage-ways or intercalants for storing and conducting mono-hydrogen, protons, or the like. The hydrogen storage material may store at least ten percent by weight hydrogen (132, 134) at ambient temperature and pressure.
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2017-05-01
SUDDEN EXPANSION 5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62203F 6. AUTHOR(S) Joseph Michael Cronin 5d. PROJECT ...heat transfer in order to manage the ever-increasing airframe and engine heat loads. Two-phase liquid-vapor refrigerant systems are one solution for...were compared with pressure drop correlations. 15. SUBJECT TERMS thermal management , two-phase flow, flow visualization, electric capacitance
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Low-cost method for producing extreme ultraviolet lithography optics
Folta, James A [Livermore, CA; Montcalm, Claude [Fort Collins, CO; Taylor, John S [Livermore, CA; Spiller, Eberhard A [Mt. Kisco, NY
2003-11-21
Spherical and non-spherical optical elements produced by standard optical figuring and polishing techniques are extremely expensive. Such surfaces can be cheaply produced by diamond turning; however, the roughness in the diamond turned surface prevent their use for EUV lithography. These ripples are smoothed with a coating of polyimide before applying a 60 period Mo/Si multilayer to reflect a wavelength of 134 .ANG. and have obtained peak reflectivities close to 63%. The savings in cost are about a factor of 100.
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The Resurrection of Laplace’s Method of Initial Orbit Determination
1983-01-17
and retrograde, at least one-third of that of a main belt asteroid. Presumably it was the strange motion that kept the Minor Planet Center from...main- belt minor planets. For an Earth-approaching asteroid one needs an element set for next month. Both 1982HS and 1982SA were discovered by our...pseudo-observations good to 1". A. 1982HS and 1982SA Both of these are inner main- belt , high inclination, high eccen- tricity minor planets. Since
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French Army - Family Psychological and Social Support
2006-04-01
Major de l’armée de Terre, Bureau condition du personnel 14 rue Saint-Dominique 00453 Armées FRANCE The French Army is permanently engaged on...ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) French Army...RTO-MP-HFM-134 21E - 1 French Army – Family Psychological and Social Support LCL G. BOUILLAUD French Army Staff, Quality Of Life Etat
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Miyamoto, Yutaka; Yasuda, Kenichiro; Magara, Masaaki
2014-06-01
Airborne radioactive particles released by the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident in 2011 were collected with a cascade low-pressure impactor at the Japan Atomic Energy Agency (JAEA) in Tokai, Japan, 114 km south of the FDNPP. Size-fractionated samples were collected twice, in the periods of March 17-April 1, 2011, and May 9-13, 2011. These size-fractionated samplings were carried out in the earliest days at a short distance from the FDNPP. Radioactivity of short-lived nuclides (several ten days of half-life) was determined as well as (134)Cs and (137)Cs. The elemental composition of size-fractionated samples was also measured. In the first collection, the activity median aerodynamic diameter (AMAD) of (129m)Te, (140)Ba, (134)Cs, (136)Cs and (137)Cs was 1.5-1.6 μm, while the diameter of (131)I was 0.45 μm. The diameters of (134)Cs and (137)Cs in the second collection were expressed as three peaks at <0.5 μm, 0.94 μm, and 7.8 μm. The (134)Cs/(137)Cs ratio of the first collection was 1.02 in total, but the ratio in the fine fractions was 0.91. A distribution map of (134)Cs/(137)Cs - (136)Cs/(137)Cs ratios was helpful in understanding the change of radioactive Cs composition. The Cs composition of size fractions <0.43 μm and the composition in the 1.1-2.1 μm range (including the AMAD of 1.5-1.6 μm) were similar to the calculated compositions of fuels in the reactors No. 1 and No. 3 at the FDNPP using the ORIGEN-II code. The Cs composition collected in May, 2011 was similar to the calculation results of reactor No. 2 fuel composition. The change of Cs composition implies that the radioactive Cs was released from the three reactors at the FDNPP via different processes. Copyright © 2014 Elsevier Ltd. All rights reserved.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Chen, Tianjun; Gao, Fei; Feng, Sifang
2015-08-28
MicroRNAs have been shown to act as crucial modulators during carcinogenesis. Recent studies have implied that miR-134 expression associated with epithelial-to-mesenchymal transition phenotype and invasive potential of NSCLC cells. Our study investigated the pathogenic implications of miR-134 in small cell lung cancer (SCLC). Overexpression or inhibition MiR-134 expression by miR-134 mimics or miR-134 inhibitors (anti-miR-134) in SCLC cell lines was detected using qRT-PCR. Lactate dehydrogenase (LDH) assay, MTT assays and flow cytometry were performed in order to clarify the growth and apoptosis of SCLC cells which had been transfected with miR-134 mimics or anti-miR-134. WWOX expression in H69 cells wasmore » detected by qRT-PCR and western blot, respectively. The results showed that overexpression miR-134 was significantly promoting SCLC cells growth and inhibit its apoptosis. In addition, reduced miR-134 expression was significantly correlated with cell growth inhibition and apoptosis promotion. Furthermore, transfection of miR-134 mimics into the SCLC cells markedly down-regulated the level of WWOX, whereas, anti-miR-134 up-regulated WWOX expression. We also found that overexpression WWOX attenuate miR-134 induced H69 cells growth, and promote cell apoptosis. Moreover, miR-134 promoted cell proliferation and inhibit apoptosis via the activation of ERK1/2 pathway. These findings suggest that miR-134 may be an ideal diagnostic and prognostic marker, and may be attributed to the molecular therapy of SCLC. - Highlights: • MiR-134 play roles in small cell lung cancer cell growth and apoptosis. • MiR-134 negative regulated the level of WWOX in H69 cells. • WWOX overexpression attenuate miR-134 induced H69 cells growth. • MiR-134 promotes cell growth via the activation of ERK1/2 pathway.« less
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Gong, Ke; Xu, Fei; Grunewald, Jonathan B.
The rapid growth of intermittent renewable energy (e.g., wind and solar) demands low-cost and large-scale energy storage systems for smooth and reliable power output, where redox-flow batteries (RFBs) could find their niche. In this work, we introduce the first all-soluble all-iron RFB based on iron as the same redox-active element but with different coordination chemistries in alkaline aqueous system. The adoption of the same redox-active element largely alleviates the challenging problem of cross-contamination of metal ions in RFBs that use two redox-active elements. An all-soluble all-iron RFB is constructed by combining an iron–triethanolamine redox pair (i.e., [Fe(TEOA)OH] –/[Fe(TEOA)(OH)] 2–) andmore » an iron–cyanide redox pair (i.e., Fe(CN) 6 3–/Fe(CN) 6 4–), creating 1.34 V of formal cell voltage. Furthermore, good performance and stability have been demonstrated, after addressing some challenges, including the crossover of the ligand agent. As exemplified by the all-soluble all-iron flow battery, combining redox pairs of the same redox-active element with different coordination chemistries could extend the spectrum of RFBs.« less
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Performance analysis of the electric vehicle air conditioner by replacing hydrocarbon refrigerant
NASA Astrophysics Data System (ADS)
Santoso, Budi; Tjahjana, D. D. D. P.
2017-01-01
The thermal comfort in passenger cabins needs an automotive air-conditioning system. The electric vehicle air conditioner system is driven by an electric compressor which includes a compressor and an electric motor. Almost air-conditioning system uses CFC-12, CFC-22 and HFC-134a as refrigerant. However, CFC-12 and CFC-22 will damage the ozone layer. The extreme huge global warming potentials (GWP) values of CFC-12, CFC-22, and HFC-134a represent the serious greenhouse effect of Earth. This article shows new experimental measurements and analysis by using a mixture of HC-134 to replace HFC-134a. The result is a refrigerating effect, the coefficient of performance and energy factor increase along with cooling capacity, both for HFC-134a and HC-134. The refrigerating effect of HC-134 is almost twice higher than HFC-134a. The coefficient of performance value of HC-134 is also 36.42% greater than HFC-134a. Then, the energy factor value of HC-134 is 3.78% greater than HFC-134a.
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Zou, Ying S; Hoppman, Nicole L; Singh, Zeba N; Sawhney, Sameer; Kotiah, Sandy D; Baer, Maria R
2017-04-01
We report a NUMA1-PDGFRB fusion in a myeloproliferative neoplasm with eosinophilia in a 61-year old man, with response to imatinib mesylate therapy. A t(5;11) chromosome translocation involving bands 5q32 and 11q13.4 was identified by metaphase chromosome analysis, and rearrangement of the platelet-derived growth factor receptor beta (PDGFRB) gene on 5q32 was demonstrated by FISH using a PDGFRB break-apart probe set. Bacterial artificial chromosome (BAC) FISH mapping of the PDGFRB fusion partner gene narrowed the breakpoint at 11q13.4 to a 150 kb genomic region containing three genes, including NUMA1. Mate pair sequencing analysis demonstrated NUMA1-PDGFRB fusion. The fusion protein includes coiled-coil domains of nuclear mitotic apparatus protein 1 (NuMA1, involved in protein homodimerization and heteroassociation) and tyrosine kinase domains of PDGFRB. Diverse rearrangements involving the PDGFRB gene have been identified in myeloid and lymphoid neoplasms with eosinophilia, but rearrangement of the nuclear mitotic apparatus protein 1 (NUMA1) gene has previously been reported in a human malignancy in only one instance, a NUMA1-RARA fusion caused by a t(11;17) translocation in a patient with acute promyelocytic leukemia. The NUMA1-PDGFRB fusion is the second instance of rearrangement of NUMA1, encoding an element of the mitotic apparatus, in human cancer. Copyright © 2017 Elsevier Inc. All rights reserved.
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NASA Astrophysics Data System (ADS)
Visetpotjanakit, S.; Kaewpaluek, S.
2017-06-01
A proficiency test (PT) exercise has proposed by the International Atomic Energy Agency (IAEA) in the frame of the IAEA Technical Cooperation project RAS/7/021 “Marine benchmark study on the possible impact of the Fukushima radioactive releases in the Asia-Pacific Region for Caesium Determination in Sea Water” since 2012. In 2015 the exercise was referred to Proficiency Test for Tritium, Strontium and Caesium Isotopes in Seawater 2015 (IAEA-RML-2015-02) to analyse3H, 134Cs, 137Cs and90Sr in a seawater sample. OAP was one of the 17 laboratories from 15 countries from Asia-Pacific Region who joined the PT exercise. The aim of our participation was to validate our analytical performance for the accurate determination of radionuclides in seawater by developed methods of radiochemical analysis. OAP submitted results determining the concentration for the three elements i.e. 134Cs, 137Cs and90Sr in seawater to the IAEA. A critical review was made to check suitability of our methodology and the criteria for the accuracy, precision and trueness of our data. The results of both 134Cs and 137Cs passed all criteria which were assigned “Accepted” statuses. Whereas 90Sr analysis did not pass the accuracy test therefore it was considered as “Not accepted” Our results and all other participant results with critical comments were published in the IAEA proficiency test report.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Gündoğdu, Gülsüm; Aytaç, Sevim Peri; Müller, Melanie
Two novel compounds, 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C 23H 16F 2N 4S) (1) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C 23H 16ClFN 4S) (2), have been designed and synthesized as cytotoxic agents. The compounds were characterized by infrared, proton nuclear magnetic resonance, mass spectral data, elemental analysis and X-ray powder diffraction. The present study comprises spectral data and crystal structures of these novel compounds determined from synchrotron X-ray powder diffraction data. The structure solutions were obtained by simulated annealing. The final structures were achieved by Rietveld refinement using soft restraints for all bond lengths, bond angles, and planar groups. Both compounds crystallize in space groupmore » $$P\\bar 1$$,Z= 2, with the unit-cell parametersa= 6.37433(9),b= 11.3641(2),c= 14.09115(19) Å,α= 80.1740(8)°,β= 85.1164(8)°,γ= 80.9831(10)°,V= 991.55(3) Å 3of compound (1) anda= 6.53736(6),b= 11.55725(15),c= 14.01373(13) Å,α= 80.3323(7)°,β= 84.8939(6)°,γ= 79.3954(8)°,V= 1024.08(2) Å 3of compound (2). Structural analyses reveal that the title compounds are isostructural.« less
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The market trend analysis and prospects of scaffolds for stem cells.
Lee, Seou; Kwon, Taehoon; Chung, Eun Kyung; Lee, Joon Woo
2014-01-01
Scaffolds are one of the three most important elements constituting the basic concept of regenerative medicine, and are included in the core technology of regenerative medicine along with stem cells and tissue engineering. Stem cells are very important technology because they are directly responsible for the regenerative treatment of the disease and the damaged tissue, but with regards to the technology and the products that use stem cells exclusively, there is a technical limitation of limited survival rate and the engraftment rate of the transplanted cell, and rather than recovering the damaged tissue fundamentally, there is a limit that the concept is more of just another medicine treatment using cells. A scaffold is a natural or synthetic biocompatible material transplanted into a human body to be used as the exclusive treatment or as an assisted method of another treatment of a disease and for the recovery of damaged tissue. Therefore, according to the characteristics of the tissue to be applied, scaffolds must have the characteristics such as the excellent biocompatibility, biodegradability, minimum immunity and inflammation, proper mechanical strength and interaction between the material and the cells. The world stem cell market was approximately 2.715 billion dollars in 2010, and with a growth rate of 16.8% annually, a market of 6.877 billion dollars will be formed in 2016. From 2017, the expected annual growth rate is 10.6%, which would expand the market to 11.38 billion dollars by 2021. Meanwhile, the world scaffold element technology market was approximately 4.57 million dollars in 2013, and by increasing 13.4% annually, it is estimated to expand to 10.63 million dollars by 2020. The Korean scaffold element technology market was about 22 million dollars in 2013, and with a steady growth of approximately 13.4% every year, it is prospected to be about 52 million dollars by 2020. In comparison to the medical material and medicine sales growth rate, the future scaffold element technology market is judged to be higher in growth possibility.
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2018-01-01
The objective of this study was to investigate the content of essential elements in medicinal plants in the Kingdom of Saudi Arabia (KSA). Five different medical plants (mahareeb (Cymbopogon schoenanthus), sheeh (Artemisia vulgaris), harjal (Cynanchum argel delile), nabipoot (Equisetum arvense), and cafmariam (Vitex agnus-castus)) were collected from Madina city in the KSA. Five elements Fe, Mn, Zn, Cu, and Se were determined by using inductively coupled plasma mass spectrometry (ICP-MS). Fe levels were the highest and Se levels were the lowest in all plants. The range levels of all elements in all plants were as follows: Fe 193.4–1757.9, Mn 23.6–143.7, Zn 15.4–32.7, Se 0.13–0.92, and Cu 11.3–21.8 µg/g. Intakes of essential elements from the medical plants in infusion were calculated: Fe 4.6–13.4, Mn 6.7–123.2, Zn 7.0–42.7, Se 0.14–1.5, and Cu 1.5–5.0 µg/dose. The calculated intakes of essential elements for all plants did not exceed the daily intake set by the World Health Organization (WHO) and European Food Safety Authority (EFSA). These medicinal plants may be useful sources of essential elements, which are vital for health. PMID:29744234
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2010-11-04
CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, the Alpha Magnetic Spectrometer-2 (AMS) sits in its cargo element work stand, where technicians will continue to process the experiment for launch. AMS is designed to operate as an external experiment on the International Space Station. It will use the unique environment of space to study the universe and its origin by searching for dark matter. AMS will fly to the station aboard space shuttle Endeavour's STS-134 mission targeted to launch Feb. 27, 2011. Photo credit: NASA/Jack Pfaller
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2010-11-04
CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, the Alpha Magnetic Spectrometer-2 (AMS) sits in its cargo element work stand, where technicians will continue to process the experiment for launch. AMS is designed to operate as an external experiment on the International Space Station. It will use the unique environment of space to study the universe and its origin by searching for dark matter. AMS will fly to the station aboard space shuttle Endeavour's STS-134 mission targeted to launch Feb. 27, 2011. Photo credit: NASA/Jack Pfaller
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2010-11-04
CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, the Alpha Magnetic Spectrometer-2 (AMS) sits in its cargo element work stand, where more processing will take place. AMS is designed to operate as an external experiment on the International Space Station. It will use the unique environment of space to study the universe and its origin by searching for dark matter. AMS will fly to the station aboard space shuttle Endeavour's STS-134 mission targeted to launch Feb. 27, 2011. Photo credit: NASA/Jack Pfaller
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[Overexpressed miRNA-134b inhibits proliferation and invasion of CD133+ U87 glioma stem cells].
Liu, Yifeng; Zhang, Baochao; Wen, Changming; Wen, Gongling; Zhou, Guoping; Zhang, Jingwei; He, Haifa; Wang, Ning; Li, Wei
2017-05-01
Objective To investigate the role of microRNA-134b (miR-134b) in the tumorigenesis of glioma stem cells (GSCs) and the possible molecular mechanism. Methods Real-time quantitative PCR (qRT-PCR) was used to evalate the expression of miR-134b in CD133 + and CD133 - U87 GSCs. A lentiviral vector overexpressing miR-134b in U87 GSCs was constructed, and the effect of miR-134b overexpression on matrix metalloproteinase-2 (MMP-2), MMP-9 and MMP-12 expressions at both mRNA and protein levels were detected by qRT-PCR and Western blotting, respectively. Transwell TM assay was performed to determine the effect of miR-134b overexpression on GSCs invasion ability. Tumor xenograft models in nude mice were established to evaluate the effect of miR-134b overexpression on tumorgenesis in vivo. Results The qRT-PCR showed that, compared with CD133 - cells, miR-134b was significantly down-regulated in CD133 + cells. Cell line over-expressing miR-134b was successfully established, and miR-134b was up-regulated significantly compared with empty vector control. Overexpression of miR-134b remarkably inhibited the invasion of U87 GSCs and the expression of MMP-12. However, overexpression of miR-134b did not affect MMP-2 and MMP-9 expressions. miR-134b also suppressed U87 GSCs xenograft growth in vivo. Tumor volume in tumor xenograft model group was significantly lower than that in control group, and tumor weight decreased by 42% in the former group. Conclusion Overexpression of miR-134b inhibits the growth and invasion of CD133 + GSCs.
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You, Xin; Qin, Zhen; Li, Yan-Xiao; Yan, Qiao-Juan; Li, Bin; Jiang, Zheng-Qiang
2018-06-01
Mannan is one of the major constituent groups of hemicellulose, which is a renewable resource from higher plants. β-Mannanases are enzymes capable of degrading lignocellulosic biomass. Here, an endo-β-mannanase from Rhizopus microsporus (RmMan134A) was cloned and expressed. The recombinant RmMan134A showed maximal activity at pH 5.0 and 50 °C, and exhibited high specific activity towards locust bean gum (2337 U/mg). To gain insight into the substrate-binding mechanism of RmMan134A, four complex structures (RmMan134A-M3, RmMan134A-M4, RmMan134A-M5 and RmMan134A-M6) were further solved. These structures showed that there were at least seven subsites (-3 to +4) in the catalytic groove of RmMan134A. Mannose in the -1 subsite hydrogen bonded with His113 and Tyr131, revealing a unique conformation. Lys48 and Val159 formed steric hindrance, which impedes to bond with galactose branches. In addition, the various binding modes of RmMan134A-M5 indicated that subsites -2 to +2 are indispensable during the hydrolytic process. The structure of RmMan134A-M4 showed that mannotetrose only binds at subsites +1 to +4, and RmMan134A could therefore not hydrolyze mannan oligosaccharides with degree of polymerization ≤4. Through rational design, the specific activity and optimal conditions of RmMan134A were significantly improved. The purpose of this paper is to investigate the structure and function of fungal GH family 134 β-1,4-mannanases, and substrate-binding mechanism of GH family 134 members. Copyright © 2018 Elsevier B.V. All rights reserved.
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Wang, Chun-Hua; Xie, Xian-Rui; Liu, Wen-Shuai; Hou, Gui-Ge; Sun, Ju-Feng; Zhao, Feng; Cong, Wei; Li, Hong-Juan; Xin, Wen-Yu
2017-11-01
Twenty-one novel 5-phenyl-1,3,4-oxadiazole-2-thiol (POT) substituted N-hydroxyethyl quaternary ammonium salts (6a-g, 7a-g, 8a-g) were prepared and characterized by FTIR, NMR, and elemental analysis. Compounds 6a, 6c, and 8a were confirmed by X-ray single-crystal diffraction. They display the unsurpassed antibacterial activity against Staphylococcus aureus, α-H-tococcus, Escherichia coli, P. aeruginosa, Proteus vulgaris, Canidia Albicans, especially 6g, 7g, 8g with dodecyl group. Compounds 8a-d with N,N-dihydroxyethyl and POT groups display unsurpassed antibacterial activity and non-toxicity. The structure-activity relationships indicate that POT and flexible dihydroxyethyl group in QAS are necessary for antibacterial activity and cytotoxicity. SEM and TEM images of E. coli morphologies of 8d show the antibacterial agents can adhere to membrane surfaces to inhibit bacterial growth by disrupting peptidoglycan formation and releasing bacterial cytoplasm from cell membranes. © 2017 John Wiley & Sons A/S.
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Harish, Kikkeri P; Mohana, Kikkeri N; Mallesha, Lingappa; Veeresh, Bantal
2014-04-01
A series of new 2-methyl-2-[3-(5-piperazin-1-yl-[1,3,4]oxadiazol-2-yl)-phenyl]-propionitrile derivatives 8a-o, 9a-c, 10a-d, and 11a-d were synthesized to meet the structural requirements essential for anticonvulsant property. The structures of all the synthesized compounds were confirmed by means of (1)H NMR, (13)C NMR, and mass spectral studies. The purity of the novel compounds was confirmed by elemental analyses. All the compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method and their neurotoxic effects were determined by rotorod test. Compounds 8d, 8e, and 8f were found to be the most potent of this series. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg). The efforts were also made to establish the structure-activity relationships among the synthesized compounds. The pharmacophore model was used to validate the anticonvulsant activity of the synthesized molecules. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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The Roles of Flares and Shocks in determining SEP Abundances
NASA Technical Reports Server (NTRS)
Cane, H. V.; Mewaldt, R. A.; Cohen, C. M. S.; vonRosenvinge, T. T.
2007-01-01
We examine solar energetic particle (SEP) event-averaged abundances of Fe relative to O and intensity versus time profiles at energies above 25 MeV/nucleon using the SIS instrument on ACE. These data are compared with solar wind conditions during each event and with estimates of the strength of the associated shock based on average travel times to 1 AU. We find that the majority of events with an Fe to 0 abundance ratio greater than two times the average 5-12 MeV/nuc value for large SEP events (0.134) occur in the western hemisphere. Furthermore, in most of these Fe-rich events the profiles peak within 12 hours of the associated flare, suggesting that some of the observed interplanetary particles are accelerated in these flares. The vast majority of events with Fe/O below 0.134 are influenced by interplanetary shock acceleration. We suggest that variations in elemental composition in SEP events mainly arise from the combination of flare particles and shock acceleration of these particles and/or the ambient medium.
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Zhang, Yan; Liu, Xing-Hai; Zhan, Yi-Zhou; Zhang, Li-Yuan; Li, Zheng-Ming; Li, Yong-Hong; Zhang, Xiao; Wang, Bao-Lei
2016-10-01
A series of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases have been conveniently synthesized in good yields. Their structures were characterized by IR, (1)H NMR, (13)C NMR and elemental analysis. The preliminary bioassay results indicated that some of the compounds showed promising in vitro fungicidal activities towards several test plant fungi; some of them exhibited significant herbicidal activities against Brassica campestris and excellent in vitro inhibitory activities against rice ketol-acid reductoisomerase (KARI). Among 14 novel compounds, 8c, 8d and 8m showed potent KARI inhibitory activities with Ki value of (0.96±0.42), (3.86±0.49) and (3.10±0.71) μmol/L, respectively, and were comparable with IpOHA. These compounds could be novel KARI inhibitors for further investigation. The density functional theory (DFT) calculations and molecular docking were carried out to study the structure-activity relationship (SAR) of the active inhibitors in this Letter. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Kumar, S.; Srivastava, D. P.
2010-01-01
An efficient electrochemical method for the preparation of 2-amino-5-substituted-1,3,4-oxadiazoles (4a-k) at platinum anode through the electrooxidation of semicarbazone (3a-k) at controlled potential electrolysis has been reported in the present study. The electrolysis was carried out in the acetic acid solvent and lithium perchlorate was used as supporting electrolyte. The products were characterized by IR,1H-NMR,13C-NMR, mass spectra and elemental analysis. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., Klebsilla penumoniae, Escherichia coli, Bassilus subtilis and Streptococcus aureus and antifungal activity against Aspergillus niger and Crysosporium pannical and results have been compared with the standard antibacterial streptomycin and antifungal griseofulvin. Compounds exhibits significant antibacterial activity and antifungal activity. Compounds 4a and g exhibited equal while 4c, d, i and j slightly less antibacterial activity than standard streptomycin. Compounds 4a and g exhibited equal while 4b, c, d, f and i displayed slightly less antifungal activity than standard griseofulvins. PMID:21218056
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RETREG1 (FAM134B): A new player in human diseases: 15 years after the discovery in cancer.
Islam, Farhadul; Gopalan, Vinod; Lam, Alfred King-Yin
2018-06-01
FAM134B (family with sequence similarity 134, member B)/RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases. FAM134B inhibition contributes to impair proteostasis in the ER due to the accumulation of misfolded or aggregated proteins, which in turn leads to compromised neuronal survival and progressive neuronal degenerative diseases. Mutations in FAM134B associated with hereditary sensory and autonomic neuropathy type IIB (HSAN IIB). Selective cleavage of FAM134B by Dengue, Zika, and West Nile virus encoded protease NS2B3 leads to the increased production of infection units, whereas upregulation of FAM134B inhibits viral replication. In cancer, FAM134B acts as a tumor suppressor and inhibit cancer growth both in-vitro and in-vivo. Pharmacological upregulation of FAM134B resulted in reduced cancer cell growth and proliferation. In addition, FAM134B mutations are common in patients with colorectal adenocarcinoma, and oesophageal squamous cell carcinoma. These mutations and expression changes of FAM134B were associated with the biological aggressiveness of these cancers. FAM134B also plays a role in allergic rhinitis, vascular dementia, and identification of stem cells. Taken together, information available in the literature suggests that FAM134B plays critical roles in human diseases, by interacting with different biological and chemical mediators, which are primarily regulated by ER turnover. © 2017 Wiley Periodicals, Inc.
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13 CFR 134.402 - Appeal petition.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Appeal petition. 134.402 Section 134.402 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING... § 134.402 Appeal petition. In addition to the requirements of § 134.203, an appeal petition must state...
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19 CFR 134.34 - Certain repacked articles.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certain repacked articles. 134.34 Section 134.34... TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.34 Certain repacked articles. (a) Exception for repacked articles. An exception under § 134.32(d) may be authorized in the...
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19 CFR 134.34 - Certain repacked articles.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 19 Customs Duties 1 2013-04-01 2013-04-01 false Certain repacked articles. 134.34 Section 134.34... TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.34 Certain repacked articles. (a) Exception for repacked articles. An exception under § 134.32(d) may be authorized in the...
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19 CFR 134.34 - Certain repacked articles.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 19 Customs Duties 1 2014-04-01 2014-04-01 false Certain repacked articles. 134.34 Section 134.34... TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.34 Certain repacked articles. (a) Exception for repacked articles. An exception under § 134.32(d) may be authorized in the...
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19 CFR 134.34 - Certain repacked articles.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 1 2012-04-01 2012-04-01 false Certain repacked articles. 134.34 Section 134.34... TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.34 Certain repacked articles. (a) Exception for repacked articles. An exception under § 134.32(d) may be authorized in the...
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19 CFR 134.34 - Certain repacked articles.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Certain repacked articles. 134.34 Section 134.34... TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.34 Certain repacked articles. (a) Exception for repacked articles. An exception under § 134.32(d) may be authorized in the...
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Lubberink, Mark; Lundqvist, Hans; Tolmachev, Vladimir
2002-02-21
We propose the use of the Auger electron and positron-emitting generator 134Ce/134La (half-lives 3.16 d and 6.45 min) for radionuclide therapy. It combines emission of high-energy beta particles with Auger electrons. The high-energy beta particles have similar energies as those emitted by 90Y. Many cancer patients receiving radionuclide therapy have both bulk tumours, which are best treated with high-energy beta particles, and single spread cells or micrometastasis, which are preferably treated with low-energy electrons such as Auger and conversion electrons. Furthermore, the positron-emitting 134La can be used to study kinetics and dosimetry using PET. Production and PET performance were investigated and theoretical dosimetry calculations were made. PET resolution, recovery and quantitative accuracy were slightly degraded for 134La compared to 18F. 134Ce/134La absorbed doses to single cells were higher than absorbed doses from 90Y and 111In. Absorbed doses to spheres representing bulk tumours were almost as high as for 90Y, and a factor 10 higher than for 111In. Whole-body absorbed doses, based on kinetics of the somatostatin analogue octreotide, were higher for 134Ce/134La than for 90Y because of the 134La annihilation photons. This initial study of the therapeutic possibilities of 134Ce/134La is encouraging and justifies further investigations.
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Sakaguchi, Aya; Steier, Peter; Takahashi, Yoshio; Yamamoto, Masayoshi
2014-04-01
Black-colored road dusts were collected in high-radiation areas in Fukushima Prefecture. Measurement of (236)U and Pu isotopes and (134,137)Cs in samples was performed to confirm whether refractory elements, such as U and Pu, from the fuel core were discharged and to ascertain the extent of fractionation between volatile and refractory elements. The concentrations of (134,137)Cs in all samples were exceptionally high, ranging from 0.43 to 17.7 MBq/kg, respectively. (239+240)Pu was detected at low levels, ranging from 0.15 to 1.14 Bq/kg, and with high (238)Pu/(239+240)Pu activity ratios of 1.64-2.64. (236)U was successfully determined in the range of (0.28 to 6.74) × 10(-4) Bq/kg. The observed activity ratios for (236)U/(239+240)Pu were in reasonable agreement with those calculated for the fuel core inventories, indicating that trace amounts of U from the fuel cores were released together with Pu isotopes but without large fractionation. The quantities of U and (239+240)Pu emitted to the atmosphere were estimated as 3.9 × 10(6) Bq (150 g) and 2.3 × 10(9) Bq (580 mg), respectively. With regard to U, this is the first report to give a quantitative estimation of the amount discharged. Appreciable fractionation between volatile and refractory radionuclides associated with the dispersal/deposition processes with distance from the Fukushima Dai-ichi Nuclear Power Plant was found.
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Sun, Cheng-Cao; Li, Shu-Jun; Li, De-Jia
2016-01-01
Hsa-miRNA-134 (miR-134) has recently been discovered to have anticancer efficacy in different organs. However, the role of miR-134 on non-small cell lung cancer (NSCLC) is still ambiguous. In this study, we investigated the role of miR-134 on the development of NSCLC. The results indicated that miR-134 was significantly down-regulated in primary tumor tissues and very low levels were found in NSCLC cell lines. Ectopic expression of miR-134 in NSCLC cell lines significantly suppressed cell growth as evidenced by cell viability assay, colony formation assay and BrdU staining, through inhibition of cyclin D1, cyclin D2, CDK4 and up-regulation of p57(Kip2) and p21(Waf1/Cip1). In addition, miR-134 induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein Bcl2. Moreover, miR-134 inhibited cellular migration and invasiveness through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. Further, oncogene CCND1 was revealed to be a putative target of miR-134, which was inversely correlated with miR-134 expression in NSCLC. Taken together, our results demonstrated that miR-134 played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic CCND1. PMID:27166267
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All-soluble all-iron aqueous redox-flow battery
Gong, Ke; Xu, Fei; Grunewald, Jonathan B.; ...
2016-05-03
The rapid growth of intermittent renewable energy (e.g., wind and solar) demands low-cost and large-scale energy storage systems for smooth and reliable power output, where redox-flow batteries (RFBs) could find their niche. In this work, we introduce the first all-soluble all-iron RFB based on iron as the same redox-active element but with different coordination chemistries in alkaline aqueous system. The adoption of the same redox-active element largely alleviates the challenging problem of cross-contamination of metal ions in RFBs that use two redox-active elements. An all-soluble all-iron RFB is constructed by combining an iron–triethanolamine redox pair (i.e., [Fe(TEOA)OH] –/[Fe(TEOA)(OH)] 2–) andmore » an iron–cyanide redox pair (i.e., Fe(CN) 6 3–/Fe(CN) 6 4–), creating 1.34 V of formal cell voltage. Furthermore, good performance and stability have been demonstrated, after addressing some challenges, including the crossover of the ligand agent. As exemplified by the all-soluble all-iron flow battery, combining redox pairs of the same redox-active element with different coordination chemistries could extend the spectrum of RFBs.« less
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Gesell, Andreas; Yoshida, Kazuko; Tran, Lan T; Constabel, C Peter
2014-09-01
The apple MdMYB9 gene encodes a positive regulator of proanthocyanidin synthesis that activates anthocyanidin reductase promoters from apple and poplar via interaction with basic helix-loop-helix proteins. The regulation of proanthocyanidins (PAs, condensed tannins) is of great importance in food plants due to the many benefits of PAs in the human diet. Two candidate flavonoid MYB regulators, MdMYB9 and MdMYB11, were cloned from apple (Malus × domestica) based on their similarity to known MYB PA regulators. Transcript accumulation of both MdMYB9 and MdMYB11 was induced by high light and wounding, similar to the poplar (Populus spp) PA regulator PtMYB134. In transient activation assays with various basic helix-loop-helix (bHLH) co-regulators, MdMYB9 activated apple and poplar anthocyanidin reductase (ANR) promoters, while MdMYB11 showed no activity. Potential transcription factor binding elements were found within several ANR promoters, and the importance of the bHLH binding site (E-box) on ANR promoter activation was demonstrated via mutational analysis. The ability of MdMYB9 and PtMYB134 to reciprocally activate ANR promoters from both apple and poplar and to partner with heterologous bHLH co-factors from these plants confirms the high degree of conservation of PA regulatory complexes across species. The similarity in apple and poplar PA regulation suggests that regulatory genes from poplar could be effectively employed for metabolic engineering of the PA pathway in apple.
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The Effects of Environmental Factors on Worker Productivity in the Construction Industry.
1985-07-01
Decreased attention to direction * Deterioration of handwriting * Mental and physical fatique * Decreased hand steadiness in manual tasks * Mood ...decreased with hypoxia development (102) (134), there is a deterioration in handwriting (101) (134), mental fatique was noted (3) (134), and hand...steadiness occurred in manual tasks (116) (134). Mood changes were also observed under these condi- tions. Shephard (102) (134) relates the following: Two
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 29 2011-07-01 2009-07-01 true [Reserved] 415.134 Section 415.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Sulfate Production Subcategory § 415.134...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 29 2014-07-01 2012-07-01 true [Reserved] 415.134 Section 415.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Sulfate Production Subcategory § 415.134...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 415.134 Section 415.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Sulfate Production Subcategory § 415.134...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 30 2012-07-01 2012-07-01 false [Reserved] 415.134 Section 415.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Sulfate Production Subcategory § 415.134...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true [Reserved] 415.134 Section 415.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Potassium Sulfate Production Subcategory § 415.134...
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Pritchett, Joshua C; Green, Jaime S; Thomm, Angela M; Knox, Konstance K; Verneris, Michael R; Lund, Troy C
2016-12-15
Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4 + CD134 + / neg-lo and CD8 + CD134 + / neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4 + CD134 + cells as compared to CD4 + CD134 neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8 + CD134 +/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4 + CD134 + cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
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1976-06-14
3.37 LVliCT 13-3-38 LOCX 13-3-39 LOC ~ 13.4 Laoeled-Cornrnon Variaole Descriptions 13 • 4 · 1 l-1E1..ffi i’ 13·4·2 TA.SINF 13·4·3 MlSCEL 13.4.4...four parameters, described in the following: Qgr,pmeter ANAME ID LOC I FORCE description name of list element number of list to search set by...vrNR to the circuit· For such a case, subroutine FIND sets the ( LOC + 2)th (Properly speaking, the IU~~SAT table should also be used for this purpose
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28 CFR 115.134 - Specialized training: Investigations.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Specialized training: Investigations. 115.134 Section 115.134 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Training and Education § 115.134 Specialized training...
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28 CFR 115.134 - Specialized training: Investigations.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Specialized training: Investigations. 115.134 Section 115.134 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Training and Education § 115.134 Specialized training...
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28 CFR 115.134 - Specialized training: Investigations.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Specialized training: Investigations. 115.134 Section 115.134 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Standards for Lockups Training and Education § 115.134 Specialized training...
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Code of Federal Regulations, 2012 CFR
2012-10-01
... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...
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Code of Federal Regulations, 2010 CFR
2010-10-01
... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...
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Code of Federal Regulations, 2013 CFR
2013-10-01
... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Stipends. 600.134 Section 600.134 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MAGNUSON-STEVENS ACT PROVISIONS Regional Fishery Management Councils § 600.134...
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Code of Federal Regulations, 2010 CFR
2010-10-01
... 49 Transportation 2 2010-10-01 2010-10-01 false Vehicles. 176.134 Section 176.134 Transportation... Class 1 (Explosive) Materials Stowage § 176.134 Vehicles. Closed vehicles may be used to transport Class... requirements relating to the transport of Class 1 (explosive) materials in vehicles. ...
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Code of Federal Regulations, 2012 CFR
2012-10-01
... 49 Transportation 2 2012-10-01 2012-10-01 false Vehicles. 176.134 Section 176.134 Transportation... Class 1 (Explosive) Materials Stowage § 176.134 Vehicles. Closed vehicles may be used to transport Class... requirements relating to the transport of Class 1 (explosive) materials in vehicles. ...
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Code of Federal Regulations, 2011 CFR
2011-10-01
... 49 Transportation 2 2011-10-01 2011-10-01 false Vehicles. 176.134 Section 176.134 Transportation... Class 1 (Explosive) Materials Stowage § 176.134 Vehicles. Closed vehicles may be used to transport Class... requirements relating to the transport of Class 1 (explosive) materials in vehicles. ...
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42 CFR 410.134 - Provider qualifications.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 42 Public Health 2 2012-10-01 2012-10-01 false Provider qualifications. 410.134 Section 410.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider...
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42 CFR 410.134 - Provider qualifications.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 42 Public Health 2 2011-10-01 2011-10-01 false Provider qualifications. 410.134 Section 410.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider...
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42 CFR 410.134 - Provider qualifications.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 2 2010-10-01 2010-10-01 false Provider qualifications. 410.134 Section 410.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider...
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42 CFR 410.134 - Provider qualifications.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 42 Public Health 2 2014-10-01 2014-10-01 false Provider qualifications. 410.134 Section 410.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider...
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42 CFR 410.134 - Provider qualifications.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 42 Public Health 2 2013-10-01 2013-10-01 false Provider qualifications. 410.134 Section 410.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 30 2011-07-01 2011-07-01 false [Reserved] 426.134 Section 426.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GLASS MANUFACTURING POINT SOURCE CATEGORY Hand Pressed and Blown Glass Manufacturing Subcategory § 426.134 [Reserved] ...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 29 2010-07-01 2010-07-01 false [Reserved] 426.134 Section 426.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GLASS MANUFACTURING POINT SOURCE CATEGORY Hand Pressed and Blown Glass Manufacturing Subcategory § 426.134 [Reserved] ...
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9 CFR 2.134 - Contingency planning.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Contingency planning. 2.134 Section 2.134 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Miscellaneous § 2.134 Contingency planning. (a) Dealers, exhibitors...
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9 CFR 2.134 - Contingency planning.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Contingency planning. 2.134 Section 2.134 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Miscellaneous § 2.134 Contingency planning. (a) Dealers, exhibitors...
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7 CFR 457.134 - Peanut crop insurance provisions.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 6 2010-01-01 2010-01-01 false Peanut crop insurance provisions. 457.134 Section 457.134 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.134 Peanut crop insurance...
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46 CFR 134.130 - New construction.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 46 Shipping 4 2013-10-01 2013-10-01 false New construction. 134.130 Section 134.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS ADDED PROVISIONS FOR LIFTBOATS § 134.130 New construction. Each applicant for an original Certificate of Inspection and for...
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46 CFR 134.130 - New construction.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 46 Shipping 4 2014-10-01 2014-10-01 false New construction. 134.130 Section 134.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS ADDED PROVISIONS FOR LIFTBOATS § 134.130 New construction. Each applicant for an original Certificate of Inspection and for...
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Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 8 2014-01-01 2014-01-01 false Reports. 966.134 Section 966.134 Agriculture... Regulations Exemption Procedures § 966.134 Reports. Persons handling tomatoes under exemption certificates shall, at such times as may be specified in such certificates, report thereon to the committee the names...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 8 2013-01-01 2013-01-01 false Reports. 966.134 Section 966.134 Agriculture... Regulations Exemption Procedures § 966.134 Reports. Persons handling tomatoes under exemption certificates shall, at such times as may be specified in such certificates, report thereon to the committee the names...
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Chai, Sunghee; Cambronne, Xiaolu A; Eichhorn, Stephen W; Goodman, Richard H
2013-10-29
MicroRNA-134 (miR-134) serves as a widely accepted model for microRNA function in synaptic plasticity. In this model, synaptic activity stimulates miR-134 expression, which then regulates dendrite growth and spine formation. By using a ratiometric microRNA sensor, we found, unexpectedly, that miR-134 activity in cortical neurons was restricted to interneurons. Using an assay designed to trap microRNA-mRNA complexes, we determined that miR-134 interacted directly with the mRNA encoding the palmitoylation enzyme, DHHC9. This enzyme is known to palmitoylate H-Ras, a modification required for proper membrane trafficking. Treatment with bicuculline, a GABAA receptor antagonist, decreased DHHC9 expression in somatostatin-positive interneurons and membrane localization of an H-Ras reporter in a manner that depended on miR-134. Thus, although miR-134 has been proposed to affect all types of neurons, we showed that functionally active miR-134 is produced in only a selected population of neurons where it influences the expression of targets, such as DHHC9, that regulate membrane targeting of critical signaling molecules.
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A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.
Arnis, S; Fahmy, K; Hofmann, K P; Sakmar, T P
1994-09-30
A carboxylic acid residue is conserved at the cytoplasmic border of the third transmembrane segment among nearly all G protein-coupled receptors. In the visual receptor rhodopsin, replacement of the conserved Glu134 by a neutral glutamine results in enhanced transducin activation. Here we show that a key event in forming the active state of rhodopsin is proton uptake by Glu134 in the metarhodopsin II (MII) photoproduct. Site-directed mutants E134D and E134Q were studied by flash photolysis, where formation rates of their photoproducts and rates of pH change could be monitored simultaneously. Both mutants showed normal MII formation rates. However, E134D displayed a slowed rate of proton uptake and E134Q displayed a loss of light-induced uptake of two protons from the aqueous phase. Thus, Glu134 mediates light-dependent proton uptake by MII. We propose that receptor activation requires a light-induced conformational change that allows protonation of Glu134 and subsequent protonation of a second group. The strong conservation of Glu134 in G protein-coupled receptors implies a general requirement for a proton acceptor group at this position to allow light- or ligand-dependent receptor activation.
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 6 Domestic Security 1 2010-01-01 2010-01-01 false Investigation. 13.4 Section 13.4 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.4 Investigation. (a) If an Investigating Official concludes that a subpoena pursuant to the Authority conferred by...
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13 CFR 134.203 - The petition.
Code of Federal Regulations, 2010 CFR
2010-01-01
... other subparts of this part 134. For SBA Employee Disputes, see Standard Operating Procedure 37 71 02... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false The petition. 134.203 Section 134.203 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES...
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Code of Federal Regulations, 2014 CFR
2014-01-01
... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...
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Code of Federal Regulations, 2012 CFR
2012-01-01
... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... 7 Agriculture 1 2013-01-01 2013-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing Clerk...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 1 2011-01-01 2011-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing Clerk...
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Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 1 2014-01-01 2014-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing Clerk...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 1 2010-01-01 2010-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing Clerk...
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Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 1 2012-01-01 2012-01-01 false Docket number. 1.134 Section 1.134 Agriculture Office... Adjudicatory Proceedings Instituted by the Secretary Under Various Statutes § 1.134 Docket number. Each proceeding, immediately following its institution, shall be assigned a docket number by the Hearing Clerk...
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NASA Astrophysics Data System (ADS)
Gill, Jatinder; Singh, Jagdev
2018-05-01
In this work, the experimental examination was carried out using a mixture of R134a and LPG refrigerant (consisting of R134a and LPG in a proportion of 28:72 by weight) as a replacement for R134a in a vapor compression refrigeration system. Exergy and energy tests were carried out at different evaporator and condenser temperatures with controlled environmental conditions. The results showed that the exergy destruction in the compressor, condenser, evaporator, and a capillary tube of the R134a / LPG refrigeration system was found lower by approximately 11.13-3.41%, 2.24-3.43%, 12.02-13.47% and 1.54-5.61% respectively. The compressor exhibits the highest level of destruction, accompanied by a condenser, an evaporator and a capillary tube in refrigeration systems. The refrigeration capacity, COP and power consumption of the compressor of the R134a /LPG refrigeration system were detected higher and lower compared to the R134a refrigeration system by about 7.04-11.41%, 15.1-17.82%, and 3.83-8.08% respectively. Also, the miscibility of R134a and LPG blend with mineral oil discovered good. The R134a and LPG refrigerant mixture proposed in this study perform superior to R134a from component-wise exergy and energy analyses under similar experimental conditions.
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Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion
Boswell, Kristin L.; James, Declan J.; Esquibel, Joseph M.; Bruinsma, Stephen; Shirakawa, Ryutaro; Horiuchi, Hisanori
2012-01-01
Munc13-4 is a widely expressed member of the CAPS/Munc13 protein family proposed to function in priming secretory granules for exocytosis. Munc13-4 contains N- and C-terminal C2 domains (C2A and C2B) predicted to bind Ca2+, but Ca2+-dependent regulation of Munc13-4 activity has not been described. The C2 domains bracket a predicted SNARE-binding domain, but whether Munc13-4 interacts with SNARE proteins is unknown. We report that Munc13-4 bound Ca2+ and restored Ca2+-dependent granule exocytosis to permeable cells (platelets, mast, and neuroendocrine cells) dependent on putative Ca2+-binding residues in C2A and C2B. Munc13-4 exhibited Ca2+-stimulated SNARE interactions dependent on C2A and Ca2+-dependent membrane binding dependent on C2B. In an apparent coupling of membrane and SNARE binding, Munc13-4 stimulated SNARE-dependent liposome fusion dependent on putative Ca2+-binding residues in both C2A and C2B domains. Munc13-4 is the first priming factor shown to promote Ca2+-dependent SNARE complex formation and SNARE-mediated liposome fusion. These properties of Munc13-4 suggest its function as a Ca2+ sensor at rate-limiting priming steps in granule exocytosis. PMID:22508512
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Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.
Boswell, Kristin L; James, Declan J; Esquibel, Joseph M; Bruinsma, Stephen; Shirakawa, Ryutaro; Horiuchi, Hisanori; Martin, Thomas F J
2012-04-16
Munc13-4 is a widely expressed member of the CAPS/Munc13 protein family proposed to function in priming secretory granules for exocytosis. Munc13-4 contains N- and C-terminal C2 domains (C2A and C2B) predicted to bind Ca(2+), but Ca(2+)-dependent regulation of Munc13-4 activity has not been described. The C2 domains bracket a predicted SNARE-binding domain, but whether Munc13-4 interacts with SNARE proteins is unknown. We report that Munc13-4 bound Ca(2+) and restored Ca(2+)-dependent granule exocytosis to permeable cells (platelets, mast, and neuroendocrine cells) dependent on putative Ca(2+)-binding residues in C2A and C2B. Munc13-4 exhibited Ca(2+)-stimulated SNARE interactions dependent on C2A and Ca(2+)-dependent membrane binding dependent on C2B. In an apparent coupling of membrane and SNARE binding, Munc13-4 stimulated SNARE-dependent liposome fusion dependent on putative Ca(2+)-binding residues in both C2A and C2B domains. Munc13-4 is the first priming factor shown to promote Ca(2+)-dependent SNARE complex formation and SNARE-mediated liposome fusion. These properties of Munc13-4 suggest its function as a Ca(2+) sensor at rate-limiting priming steps in granule exocytosis.
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NASA Astrophysics Data System (ADS)
Cui, Zi-Ning; Li, Ya-Sheng; Hu, De-Kun; Tian, Hao; Jiang, Jia-Zhen; Wang, Yuan; Yan, Xiao-Jing
2016-01-01
A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized using Lawesson’s reagent by an efficient approach under microwave irradiation in good yields. Their structures were characterized by MS, IR, 1H NMR, 13C NMR, and elemental analysis. Their in vitro and in vivo fungicidal activities revealed that the title compounds exhibited considerable activity against five selected fungi, especially to Phytophthora infestans. In order to illustrate the mechanism of title compounds against P. infestans, scanning electron micrographs (SEM) and transmission electron micrographs (TEM) were applied. The morphological and ultrastructural studies demonstrated that compound I18 led to swelling of hyphae, thickening and proliferating multilayer cell walls, excessive septation and accumulation of dense bodies. The bioassay results indicated compound I18 might act on cell wall biosynthesis, and blocked the nutrition transportation and led to cells senescence and death. Meanwhile, compound I18 had broad fungicidal activity against other twenty different kinds of fungi. These results suggested that title compounds were eligible to be development candidates and compound I18 as a promising lead compound was worthy to be further discovery, especially against P. infestans.
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NASA Astrophysics Data System (ADS)
Gür, Mahmut; Muğlu, Halit; Çavuş, M. Serdar; Güder, Aytaç; Sayıner, Hakan S.; Kandemirli, Fatma
2017-04-01
A series of 1,3,4-thiadiazole derivatives including 2- and 3-methoxy cinnamic acids were synthesized, and their structures were elucidated by the UV, IR, 1H NMR, 13C NMR spectroscopies and elemental analysis. The UV and IR calculations of the molecules were performed by using B3LYP, HF and MP2 methods with selected 6-311++G(2d,2p), 6-311++G(3df,3pd) and cc-pvtz basis sets. Dipole moment, polarizability, chemical hardness/softness and electronegativity were also calculated and analyzed. Experimental FT-IR spectra and UV-Vis spectrum of the compounds were compared with theoretical data. Furthermore, antioxidant activities of the compounds were practised via different test methods such as 2,2-diphenyl-1-picryl-hydrazyl (DPPHrad), N,N-dimethyl-p-phenylenediamine (DMPDrad +), and 2,2‧-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTSrad +) scavenging activity assays. When compared with standards (BHA-Butylated hydroxyanisole, RUT-Rutin, and TRO-Trolox), it was observed that especially XIII and XIV which include methoxy groups at the o- and m-positions, respectively, had effective activities.
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Developing the (d,p γ) reaction as a surrogate for (n, γ) in inverse kinematics
NASA Astrophysics Data System (ADS)
Lepailleur, Alexandr; Sims, Harry; Garland, Heather; Baugher, Travis; Cizewski, Jolie A.; Ratkiewicz, Andrew; Walter, Daivid; Pain, Steven D.; Smith, Karl; Goddess Collaboration Collaboration
2017-09-01
The r-process that proceeds via (n, γ) reactions on neutron-rich nuclei is responsible for the synthesis of about half of the elements heavier than iron. Because (n, γ) measurements on short-lived isotopes are not possible, the (d,p γ) reaction is being investigated as a surrogate for (n, γ) . The experimental setup GODDESS (Gammasphere ORRUBA: Dual Detectors for Experimental Structure Studies) has been developed especially for this purpose. The Oak Ridge Rutgers University Barrel Array (ORRUBA) of position-sensitive silicon strip detectors was augmented with annular arrays of segmented strip detectors at backward and forward angles, resulting in a high-angular coverage for light ejectiles (20 to 160 degrees in the laboratory frame). The 134Xe(d,p γ) reaction, used to commission the setup, was measured in inverse kinematics with stable beams from ATLAS impinged on C2D4 targets. Reaction protons were measured (ORRUBA) in coincidence with gamma rays (Gammasphere). An overview of GODDESS and preliminary results from the 134Xe(d,p γ) study will be presented. Work supported in part by U.S. D.O.E. and National Science Foundation.
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NASA Astrophysics Data System (ADS)
Zhang, Hong-Song; Zhang, Kong-Yan; Chen, Li-Chuan; Li, Yao-Xin; Chai, Lan-Qin
2017-10-01
N-(coumarin-3-yl)-N‧-(2-amino-5-phenyl-1,3,4-thiadiazol-2-yl) urea was synthesized and characterized by elemental analysis, IR, 1H NMR, 13C NMR, UV-Vis and emission spectroscopy, as well as by single-crystal X-ray diffraction. X-ray crystallographic analyses have indicated that the crystal structure consists of two dimethyl sulfoxide (DMSO) solvent molecules and the structural geometry of DMSO is a trigonal pyramid in shape. In the crystal structure, a self-assembling two-dimensional (2-D) layer supramolecular architecture is formed through intermolecular hydrogen bonds, Cdbnd O···π (thiadiazole ring) and π···π stacking interactions. The geometry of the compound has been optimized by the DFT method and the results are compared with the X-ray diffraction data. The electronic transitions and spectral features of the compound were carried out by using DFT/B3LYP method. In addition, the antimicrobial activity was also studied, and the highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO), and HOMO-LUMO gap were also calculated.
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Code of Federal Regulations, 2010 CFR
2010-04-01
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Settlement. 134.25 Section 134.25 Foreign... Considering Applications § 134.25 Settlement. The applicant and the Department of State may agree on a proposed settlement of the award before final action on the application, either in connection with a...
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19 CFR 134.14 - Articles usually combined.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 19 Customs Duties 1 2013-04-01 2013-04-01 false Articles usually combined. 134.14 Section 134.14... TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.14 Articles usually combined. (a) Articles combined before delivery to purchaser. When an imported article is of a kind which is usually...
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19 CFR 134.14 - Articles usually combined.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Articles usually combined. 134.14 Section 134.14... TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.14 Articles usually combined. (a) Articles combined before delivery to purchaser. When an imported article is of a kind which is usually...
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19 CFR 134.14 - Articles usually combined.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 1 2012-04-01 2012-04-01 false Articles usually combined. 134.14 Section 134.14... TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.14 Articles usually combined. (a) Articles combined before delivery to purchaser. When an imported article is of a kind which is usually...
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19 CFR 134.14 - Articles usually combined.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles usually combined. 134.14 Section 134.14... TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.14 Articles usually combined. (a) Articles combined before delivery to purchaser. When an imported article is of a kind which is usually...
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19 CFR 134.14 - Articles usually combined.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 19 Customs Duties 1 2014-04-01 2014-04-01 false Articles usually combined. 134.14 Section 134.14... TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.14 Articles usually combined. (a) Articles combined before delivery to purchaser. When an imported article is of a kind which is usually...
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21 CFR 211.134 - Drug product inspection.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Drug product inspection. 211.134 Section 211.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... § 211.134 Drug product inspection. (a) Packaged and labeled products shall be examined during finishing...
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21 CFR 211.134 - Drug product inspection.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Drug product inspection. 211.134 Section 211.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... § 211.134 Drug product inspection. (a) Packaged and labeled products shall be examined during finishing...
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21 CFR 211.134 - Drug product inspection.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Drug product inspection. 211.134 Section 211.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... § 211.134 Drug product inspection. (a) Packaged and labeled products shall be examined during finishing...
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21 CFR 211.134 - Drug product inspection.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Drug product inspection. 211.134 Section 211.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS... § 211.134 Drug product inspection. (a) Packaged and labeled products shall be examined during finishing...
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19 CFR 134.53 - Examination packages.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Examination packages. 134.53 Section 134.53... TREASURY COUNTRY OF ORIGIN MARKING Articles Found Not Legally Marked § 134.53 Examination packages. (a) Site of marking—(1) Customs custody. Articles (or containers) in examination packages may be marked by...
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13 CFR 134.712 - What are the limitations on new evidence?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the limitations on new evidence? 134.712 Section 134.712 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF...-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB) Protests § 134...
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45 CFR 96.134 - Maintenance of effort regarding State expenditures.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 45 Public Welfare 1 2011-10-01 2011-10-01 false Maintenance of effort regarding State expenditures. 96.134 Section 96.134 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.134 Maintenance of effort...
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45 CFR 96.134 - Maintenance of effort regarding State expenditures.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 45 Public Welfare 1 2014-10-01 2014-10-01 false Maintenance of effort regarding State expenditures. 96.134 Section 96.134 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.134 Maintenance of effort...
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45 CFR 96.134 - Maintenance of effort regarding State expenditures.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 45 Public Welfare 1 2013-10-01 2013-10-01 false Maintenance of effort regarding State expenditures. 96.134 Section 96.134 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.134 Maintenance of effort...
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45 CFR 96.134 - Maintenance of effort regarding State expenditures.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 45 Public Welfare 1 2012-10-01 2012-10-01 false Maintenance of effort regarding State expenditures. 96.134 Section 96.134 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Substance Abuse Prevention and Treatment Block Grant § 96.134 Maintenance of effort...
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25 CFR 134.3 - Period for payments extended.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 25 Indians 1 2011-04-01 2011-04-01 false Period for payments extended. 134.3 Section 134.3 Indians... CHARGES ON INDIAN IRRIGATION PROJECTS § 134.3 Period for payments extended. Furthermore, in recent... to extend the payment of such charges over a longer period of years. ...
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25 CFR 134.3 - Period for payments extended.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 25 Indians 1 2010-04-01 2010-04-01 false Period for payments extended. 134.3 Section 134.3 Indians... CHARGES ON INDIAN IRRIGATION PROJECTS § 134.3 Period for payments extended. Furthermore, in recent... to extend the payment of such charges over a longer period of years. ...
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25 CFR 134.3 - Period for payments extended.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 25 Indians 1 2014-04-01 2014-04-01 false Period for payments extended. 134.3 Section 134.3 Indians... CHARGES ON INDIAN IRRIGATION PROJECTS § 134.3 Period for payments extended. Furthermore, in recent... to extend the payment of such charges over a longer period of years. ...
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25 CFR 134.3 - Period for payments extended.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 25 Indians 1 2012-04-01 2011-04-01 true Period for payments extended. 134.3 Section 134.3 Indians... CHARGES ON INDIAN IRRIGATION PROJECTS § 134.3 Period for payments extended. Furthermore, in recent... to extend the payment of such charges over a longer period of years. ...
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25 CFR 134.3 - Period for payments extended.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 25 Indians 1 2013-04-01 2013-04-01 false Period for payments extended. 134.3 Section 134.3 Indians... CHARGES ON INDIAN IRRIGATION PROJECTS § 134.3 Period for payments extended. Furthermore, in recent... to extend the payment of such charges over a longer period of years. ...
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13 CFR 134.409 - Decision on appeal.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Decision on appeal. 134.409 Section 134.409 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING... § 134.409 Decision on appeal. (a) A decision of the Administrative Law Judge under this subpart is the...
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13 CFR 134.708 - What is the standard of review?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What is the standard of review? 134.708 Section 134.708 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF...-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB) Protests § 134...
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13 CFR 134.404 - Decision by Administrative Law Judge.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Decision by Administrative Law Judge. 134.404 Section 134.404 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF... 8(a) Program § 134.404 Decision by Administrative Law Judge. Appeal proceedings brought under this...
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22 CFR 134.22 - Answer to application.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Answer to application. 134.22 Section 134.22 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS EQUAL ACCESS TO JUSTICE ACT; IMPLEMENTATION Procedures for Considering Applications § 134.22 Answer to application. (a) Within 30 days after service of an...
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22 CFR 134.22 - Answer to application.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Answer to application. 134.22 Section 134.22 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS EQUAL ACCESS TO JUSTICE ACT; IMPLEMENTATION Procedures for Considering Applications § 134.22 Answer to application. (a) Within 30 days after service of an...
-
22 CFR 134.22 - Answer to application.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Answer to application. 134.22 Section 134.22 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS EQUAL ACCESS TO JUSTICE ACT; IMPLEMENTATION Procedures for Considering Applications § 134.22 Answer to application. (a) Within 30 days after service of an...
-
22 CFR 134.22 - Answer to application.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Answer to application. 134.22 Section 134.22 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS EQUAL ACCESS TO JUSTICE ACT; IMPLEMENTATION Procedures for Considering Applications § 134.22 Answer to application. (a) Within 30 days after service of an...
-
22 CFR 134.22 - Answer to application.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Answer to application. 134.22 Section 134.22 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS EQUAL ACCESS TO JUSTICE ACT; IMPLEMENTATION Procedures for Considering Applications § 134.22 Answer to application. (a) Within 30 days after service of an...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Sanctions. 134.219 Section 134.219 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.219 Sanctions. A Judge may impose...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... 10 Energy 1 2013-01-01 2013-01-01 false Investigation. 13.4 Section 13.4 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.4 Investigation. (a) If an investigating official concludes that... Operations for enforcement action under the Atomic Energy Act, or to defer initiating an investigation or...
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10 CFR 501.134 - Issuance and effect of interpretations.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Issuance and effect of interpretations. 501.134 Section 501.134 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS Requests for Interpretation § 501.134 Issuance and effect of interpretations. (a) DOE may issue an...
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29 CFR 2570.134 - Consequences of default.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 9 2010-07-01 2010-07-01 false Consequences of default. 2570.134 Section 2570.134 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... ERISA Section 502(c)(7) § 2570.134 Consequences of default. For 502(c)(7) civil penalty proceedings...
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40 CFR 81.134 - Austin-Waco Intrastate Air Quality Control Region.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Austin-Waco Intrastate Air Quality Control Region. 81.134 Section 81.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.134 Austin-Waco Intrastate Air Quality Control Region. The Austin-Waco...
-
40 CFR 81.134 - Austin-Waco Intrastate Air Quality Control Region.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Austin-Waco Intrastate Air Quality Control Region. 81.134 Section 81.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.134 Austin-Waco Intrastate Air Quality Control Region. The Austin-Waco...
-
40 CFR 81.134 - Austin-Waco Intrastate Air Quality Control Region.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Austin-Waco Intrastate Air Quality Control Region. 81.134 Section 81.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.134 Austin-Waco Intrastate Air Quality Control Region. The Austin-Waco...
-
40 CFR 81.134 - Austin-Waco Intrastate Air Quality Control Region.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Austin-Waco Intrastate Air Quality Control Region. 81.134 Section 81.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.134 Austin-Waco Intrastate Air Quality Control Region. The Austin-Waco...
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13 CFR 134.210 - Intervention.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Intervention. 134.210 Section 134... BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.210 Intervention. (a) By SBA. SBA may... of the moving party's interest in the case and the necessity for intervention to protect such...
-
13 CFR 134.210 - Intervention.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Intervention. 134.210 Section 134... BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.210 Intervention. (a) By SBA. SBA may... of the moving party's interest in the case and the necessity for intervention to protect such...
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13 CFR 134.210 - Intervention.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Intervention. 134.210 Section 134... BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.210 Intervention. (a) By SBA. SBA may... of the moving party's interest in the case and the necessity for intervention to protect such...
-
13 CFR 134.210 - Intervention.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Intervention. 134.210 Section 134... BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.210 Intervention. (a) By SBA. SBA may... of the moving party's interest in the case and the necessity for intervention to protect such...
-
13 CFR 134.210 - Intervention.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Intervention. 134.210 Section 134... BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.210 Intervention. (a) By... intervention to protect such interest. An interested person is any individual, business entity, or governmental...
-
40 CFR 81.134 - Austin-Waco Intrastate Air Quality Control Region.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Austin-Waco Intrastate Air Quality Control Region. 81.134 Section 81.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.134 Austin-Waco Intrastate Air Quality Control Region. The Austin-Waco...
-
Code of Federal Regulations, 2010 CFR
2010-01-01
... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Witnesses. 185.134 Section 185.134 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.134 Witnesses. (a) Except as provided in paragraph (b) of this section, testimony at the hearing shall be given orally by witnesses under...
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12 CFR 13.4 - Recommendations to customers.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Recommendations to customers. 13.4 Section 13.4... PRACTICES § 13.4 Recommendations to customers. In recommending to a customer the purchase, sale or exchange... reasonable grounds for believing that the recommendation is suitable for the customer upon the basis of the...
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12 CFR 13.4 - Recommendations to customers.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Recommendations to customers. 13.4 Section 13.4... PRACTICES § 13.4 Recommendations to customers. In recommending to a customer the purchase, sale or exchange... reasonable grounds for believing that the recommendation is suitable for the customer upon the basis of the...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 3 2010-07-01 2010-07-01 false âCanning.â 784.134 Section 784.134 Labor Regulations... First Processing, Canning, Or Packing of Marine Products Under Section 13(a)(5) § 784.134 “Canning.” The term “canning” was defined in the legislative history of the 1949 amendments (House (Conference) Report...
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13 CFR 134.512 - What are the limitations on new evidence?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the limitations on new evidence? 134.512 Section 134.512 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF... Service-Disabled Veteran Owned Small Business Concern Protests § 134.512 What are the limitations on new...
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Code of Federal Regulations, 2014 CFR
2014-01-01
... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery which a Judge can...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery which a Judge can...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery which a Judge can...
-
Code of Federal Regulations, 2012 CFR
2012-01-01
... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery which a Judge can...
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13 CFR 134.508 - What is the standard of review?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What is the standard of review? 134.508 Section 134.508 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF... Service-Disabled Veteran Owned Small Business Concern Protests § 134.508 What is the standard of review...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... consumption and water consumption of automatic commercial ice makers. 431.134 Section 431.134 Energy... EQUIPMENT Automatic Commercial Ice Makers Test Procedures § 431.134 Uniform test methods for the measurement of energy consumption and water consumption of automatic commercial ice makers. (a) Scope. This...
-
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery...
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46 CFR 134.150 - Liftboat-jacking systems.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 46 Shipping 4 2010-10-01 2010-10-01 false Liftboat-jacking systems. 134.150 Section 134.150... FOR LIFTBOATS § 134.150 Liftboat-jacking systems. (a) For this subchapter, liftboat jacking systems are vital systems and must comply with Sections 4/1.13.1 through 4/1.13.3 of the ABS's “Rules for...
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46 CFR 134.150 - Liftboat-jacking systems.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 46 Shipping 4 2011-10-01 2011-10-01 false Liftboat-jacking systems. 134.150 Section 134.150... FOR LIFTBOATS § 134.150 Liftboat-jacking systems. (a) For this subchapter, liftboat jacking systems are vital systems and must comply with Sections 4/1.13.1 through 4/1.13.3 of the ABS's “Rules for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-24
... Authority, Foreign-Trade Zone 134, Volkswagen Group of America Chattanooga Operations, LLC (Motor Vehicles... behalf of Volkswagen Group of America Chattanooga Operations, LLC, within FTZ 134--Site 3, Chattanooga... zone procedures within FTZ 134 on behalf of Volkswagen Group of America Chattanooga Operations, LLC, as...
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24 CFR 17.134 - Procedures for salary offset: when deductions may begin.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Procedures for salary offset: when deductions may begin. 17.134 Section 17.134 Housing and Urban Development Office of the Secretary, Department... Government Salary Offset Provisions § 17.134 Procedures for salary offset: when deductions may begin. (a...
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Code of Federal Regulations, 2013 CFR
2013-04-01
... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Reports. 13.4 Section 13.4 Housing... PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 13.4 Reports. HUD shall compile and submit... report on its experience in implementing S. 1195 Official Mail Use in the Location and Recovery of...
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Code of Federal Regulations, 2011 CFR
2011-04-01
... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Reports. 13.4 Section 13.4 Housing... PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 13.4 Reports. HUD shall compile and submit... report on its experience in implementing S. 1195 Official Mail Use in the Location and Recovery of...
-
Code of Federal Regulations, 2012 CFR
2012-04-01
... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Reports. 13.4 Section 13.4 Housing... PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 13.4 Reports. HUD shall compile and submit... report on its experience in implementing S. 1195 Official Mail Use in the Location and Recovery of...
-
Code of Federal Regulations, 2010 CFR
2010-04-01
... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Reports. 13.4 Section 13.4 Housing... PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 13.4 Reports. HUD shall compile and submit... report on its experience in implementing S. 1195 Official Mail Use in the Location and Recovery of...
-
Code of Federal Regulations, 2014 CFR
2014-04-01
... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Reports. 13.4 Section 13.4 Housing... PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 13.4 Reports. HUD shall compile and submit... report on its experience in implementing S. 1195 Official Mail Use in the Location and Recovery of...
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43 CFR 13.4 - Terms of permit.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Terms of permit. 13.4 Section 13.4 Public Lands: Interior Office of the Secretary of the Interior VENDING FACILITIES OPERATED BY BLIND PERSONS § 13.4 Terms of permit. Every permit shall describe the location of the vending facilities and shall be...
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43 CFR 13.4 - Terms of permit.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Terms of permit. 13.4 Section 13.4 Public Lands: Interior Office of the Secretary of the Interior VENDING FACILITIES OPERATED BY BLIND PERSONS § 13.4 Terms of permit. Every permit shall describe the location of the vending facilities and shall be...
-
43 CFR 13.4 - Terms of permit.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Terms of permit. 13.4 Section 13.4 Public Lands: Interior Office of the Secretary of the Interior VENDING FACILITIES OPERATED BY BLIND PERSONS § 13.4 Terms of permit. Every permit shall describe the location of the vending facilities and shall be...
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13 CFR 134.408 - Summary decision.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Summary decision. 134.408 Section... § 134.408 Summary decision. (a) Generally. In any appeal under this subpart D, either party may move or cross-move for summary decision, as provided in § 134.212. (b) Summary decision based on fewer than all...
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Ha, Ji-Eun; Yang, Seung-Ju; Gong, Young-Dae
2018-02-12
An efficient solid-phase synthetic route for the construction of 1,3,4-oxadiazole and 1,3,4-thiadiazole libraries based on branching diversity-oriented synthesis (DOS) has been developed in this study. The core skeleton resins, 1,3,4-oxadiazole and 1,3,4-thiadiazole, were obtained through desulfurative and dehydrative cyclizations of thiosemicarbazide resin, respectively. Various functional groups have been introduced to the core skeleton resins, such as aryl, amine, amide, urea, thiourea, and an amino acid. Most of the libraries were purified by simple trituration without extraction or column chromatography after cleavage of the products from the solid-supported resin. As a result, we obtained high yields of pure 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives (total numbers = 128). Finally, we confirmed the drug-like properties of our library by calculation of physicochemical properties, displays of the skeletal diversities of the library in 3D-space, and occupation of a broad range of areas by their functional groups.
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Koksal, Meric; Ozkan-Dagliyan, Irem; Ozyazici, Tugce; Kadioglu, Beril; Sipahi, Hande; Bozkurt, Ayhan; Bilge, Suleyman S
2017-09-01
Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for the treatment of rheumatic arthritis, pain, and many different types of inflammatory disorders, cause serious gastrointestinal (GI) side effects. The free carboxylic acid group existing on their chemical structure is correlated with GI toxicity related with all routine NSAIDs. Replacing this functional group with the 1,3,4-oxadiazole bioisostere is a generally used strategy to obtain an anti-inflammatory agent devoid of GI side effects. In the present work, a novel group of 5-(3,4-dichlorophenyl)-1,3,4-oxadiazole-2(3H)-one Mannich bases were synthesized and characterized on the basis of IR, 1 H NMR, and elemental analysis results. The target compounds were first tested for cytotoxicity to determine a non-toxic concentration for anti-inflammatory screening. Anti-inflammatory effects of the compounds were evaluated by in vitro lipopolysaccharide (LPS)-induced NO production and in vivo carrageenan footpad edema with ulcerogenic profile. In LPS-induced RAW 264.7 macrophages, most of the compounds showed inhibitory activity on nitrite production while compounds 5a, 5h, and 5j exhibited the best profiles by suppressing the NO production. To evaluate the in vivo anti-inflammatory potency of the compounds, the inflammatory response was quantified by increment in paw size in the carrageenan footpad edema assay. The anti-inflammatory data scoring showed that compounds 5a-d, 5g, and 5j, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5g was comparable to that of the reference drug indomethacin with 53.9% and 55.5% inhibition in 60 and 120 min, respectively. © 2017 Deutsche Pharmazeutische Gesellschaft.
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Chemical manipulation of soil biota in a fescue meadow
DOE Office of Scientific and Technical Information (OSTI.GOV)
Malone, C. R.; Reichle, D. E.
Formalin, phorate, and sodium chlorate were used in field enclosures to create artificial habitats in a fescue meadow containing (1) reduced number of earthworms, (2) reduced numbers of earthworms and soil arthropods, and (3) reduction of total soil fauna and rate of microbial decomposition. Under these conditions, confined fescue litter initially decomposed more rapidly where arthropods or earthworms were suppressed than in controls with full complements of soil animals. After one year, reduction in numbers of soil animals had no net effect on litter decomposition, with faunal activity apparently having been compensated for by increased microbial activity. Where animals andmore » microbial activity were reduced, rate of litter loss was depressed initially but recovered after 10 months as the effects of chemical suppression of microbial populations subsided. Contrary to the effects on annual loss of litter, elimination of all or portions of the soil fauna depressed rates of loss of confined and buried roots, reflecting the role of animals in fragmenting roots before their decomposition by microorganisms. Habitat manipulations had pronounced effects on the mobility of 134Cs, and loss of the radionuclide from labelled litter was retarded despite an accelerated rate of decomposition. This effect apparently was associated with proliferation of microorganisms on litter and microbial immobilization of the radionuclide. Immobilization of 134Cs occurred following chemical perturbations, but only after an initial period of rapid loss resulting from increased microbial activity. Distribution of 134Cs in soil beneath tagged litter bags reflected the role of animals in element redistribution within soil. Finally, restricted vertical mobility of the nuclide occurred except where chemical application killed vegetation within the experimental enclosures.« less
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Preservation of renal blood flow by the antioxidant EUK-134 in LPS-treated pigs.
Magder, Sheldon; Parthenis, Dimitrios G; Ghouleh, Imad Al
2015-03-25
Sepsis is associated with an increase in reactive oxygen species (ROS), however, the precise role of ROS in the septic process remains unknown. We hypothesized that treatment with EUK-134 (manganese-3-methoxy N,N'-bis(salicyclidene)ethylene-diamine chloride), a compound with superoxide dismutase and catalase activity, attenuates the vascular manifestations of sepsis in vivo. Pigs were instrumented to measure cardiac output and blood flow in renal, superior mesenteric and femoral arteries, and portal vein. Animals were treated with saline (control), lipopolysaccharide (LPS; 10 µg·kg-1·h-1), EUK-134, or EUK-134 plus LPS. Results show that an LPS-induced increase in pulmonary artery pressure (PAP) as well as a trend towards lower blood pressure (BP) were both attenuated by EUK-134. Renal blood flow decreased with LPS whereas superior mesenteric, portal and femoral flows did not change. Importantly, EUK-134 decreased the LPS-induced fall in renal blood flow and this was associated with a corresponding decrease in LPS-induced protein nitrotyrosinylation in the kidney. PO2, pH, base excess and systemic vascular resistance fell with LPS and were unaltered by EUK-134. EUK-134 also had no effect on LPS-associated increase in CO. Interestingly, EUK-134 alone resulted in higher CO, BP, PAP, mean circulatory filling pressure, and portal flow than controls. Taken together, these data support a protective role for EUK-134 in the renal circulation in sepsis.
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Western, A G; Bekvalac, J
2015-09-01
Recent excavations at the Worcester Royal Infirmary revealed a large assemblage of modified skeletal remains dating to the late 19th century. The assemblage included a sample of 134 long bones, 76 of which were transected and 58 of which displayed evidence of gross pathology without transection. Transection may have been undertaken for the purposes of amputation, anatomical or morbid dissection, for surgical training or specimen preparation. In order to elucidate the motives for such modification, Direct Digital Radiography (DDR) was undertaken on the proximal and distal elements present to confirm the true prevalence of disease. The radiographic evidence revealed that some transected elements exhibited previously unobserved pathological changes. The ratios of proximal to distal elements varied between samples of pathological and non-pathological transected elements, suggesting different motives for modification. There was also a significant difference between the composition of the skeletal sample and that expected from historical records of amputation. Aggressive or acute/subacute as well as chronic stages of disease were observed, some lesions possibly relating to ascending infection following gangrenous limb ischaemia or haematogenous spread. Other rare conditions were detected using DDR, proving it to be a critical tool in the assessment of skeletal disease in the past. Copyright © 2015 Elsevier Inc. All rights reserved.
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27 CFR 31.134 - Increase in capital stock of a corporation.
Code of Federal Regulations, 2011 CFR
2011-04-01
... of a corporation. 31.134 Section 31.134 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... Registration Information Other Changes § 31.134 Increase in capital stock of a corporation. An amended registration is not required by reason of an increase in the capital stock of a corporation so long as a new...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... resulting in a violation of the Bank Holding Company Act. 225.134 Section 225.134 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.134...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... water consumption of automatic commercial ice makers. 431.134 Section 431.134 Energy DEPARTMENT OF... Automatic Commercial Ice Makers Test Procedures § 431.134 Uniform test methods for the measurement of energy and water consumption of automatic commercial ice makers. (a) Scope. This section provides the test...
-
Code of Federal Regulations, 2014 CFR
2014-01-01
... water consumption of automatic commercial ice makers. 431.134 Section 431.134 Energy DEPARTMENT OF... Automatic Commercial Ice Makers Test Procedures § 431.134 Uniform test methods for the measurement of energy and water consumption of automatic commercial ice makers. (a) Scope. This section provides the test...
-
Code of Federal Regulations, 2013 CFR
2013-07-01
... 32 National Defense 6 2013-07-01 2013-07-01 false Arm signals. 935.134 Section 935.134 National... WAKE ISLAND CODE Motor Vehicle Code § 935.134 Arm signals. (a) Any person operating a motor vehicle and... signal for a turn or stop is made by fully extending the left arm as follows: (1) Left turn—extend left...
-
Code of Federal Regulations, 2012 CFR
2012-07-01
... 32 National Defense 6 2012-07-01 2012-07-01 false Arm signals. 935.134 Section 935.134 National... WAKE ISLAND CODE Motor Vehicle Code § 935.134 Arm signals. (a) Any person operating a motor vehicle and... signal for a turn or stop is made by fully extending the left arm as follows: (1) Left turn—extend left...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... 32 National Defense 6 2014-07-01 2014-07-01 false Arm signals. 935.134 Section 935.134 National... WAKE ISLAND CODE Motor Vehicle Code § 935.134 Arm signals. (a) Any person operating a motor vehicle and... signal for a turn or stop is made by fully extending the left arm as follows: (1) Left turn—extend left...
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13 CFR 134.304 - Commencement of appeals from size determinations and NAICS code designations.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Commencement of appeals from size determinations and NAICS code designations. 134.304 Section 134.304 Business Credit and Assistance SMALL BUSINESS... Appeals From Size Determinations and NAICS Code Designations § 134.304 Commencement of appeals from size...
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Apitanyasai, Kantamas; Amparyup, Piti; Charoensapsri, Walaiporn; Sangsuriya, Pakkakul; Tassanakajon, Anchalee
2018-05-01
Hemocyte homeostasis-associated protein (PmHHAP) was first identified as a viral-responsive gene, due to a high upregulation in transcription following white spot syndrome virus (WSSV) infection. Functional studies using RNA interference have suggested that PmHHAP is involved in hemocyte homeostasis by controlling apoptosis during WSSV infection. In this study, the role of PmHHAP in host-viral interactions was further investigated. Yeast two-hybrid assay and co-immunoprecipitation revealed that PmHHAP binds to an anti-apoptosis protein, WSSV134. The viral protein WSSV134 is a late protein of WSSV, expressed 24 h post infection (hpi). Gene silencing of WSSV134 in WSSV-infected shrimp resulted in a reduction of the expression level of the viral replication marker genes VP28, wsv477, and ie-1, which suggests that WSSV134 is likely involved in viral propagation. However, co-silencing of PmHHAP and WSSV134 counteracted the effects on WSSV infection, which implies the importance of the host-pathogen interaction between PmHHAP and WSSV134 in WSSV infection. In addition, caspase 3/7 activity was noticeably induced in the PmHHAP and WSSV134 co-silenced shrimp upon WSSV infection. Moreover, PmHHAP and WSSV134 inhibited caspase-induced activation of PmCasp in vitro in a non-competitive manner. Taken together, these results suggest that PmHHAP and WSSV134 play a role in the host-pathogen interaction and work concordantly to control apoptosis in WSSV infection. Copyright © 2018 Elsevier Ltd. All rights reserved.
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[Design and activity verification of human parathyroid hormone (1-34) mutant protein].
Qiu, Shuang; Jiang, Yue-Shui; Li, Zhi-Qin; Lei, Jian-Yong; Chen, Yun; Jin, Jian
2012-07-01
Through protein-protein BLAST of homologous sequences in different species in NCBI database and preliminary simulating molecular docking and molecular dynamics by computer software discovery studio 3.1, three amino acids R25K26K27 of natural human parathyroid hormone (1-34) with Q25E26L27 were mutated and the biological activity of the mutant peptide was evaluated. Result showed that: root mean superposition deviation RMSD value between PTH (1-34)-(RKK-QEL) and PTH (1-34) peptide main chain was 2.509 3, indicating that the differences between the two main chain structural conformation was relatively small; the interaction energy between PTH (1-34)-(RKK-QEL) and its receptor protein PTH1R had been enhanced by 7.5% compared to nature PTH (1-34), from -554.083 kcal x mol(-1) to -599.253 kcal x mol(-1); the number of hydrogen bonds was increased from 32 to 38; PTH (1-34)-(RKK-QEL) can significantly stimulate the RANKL gene expression (P < 0.01) while inhibiting the OPG gene expression (P < 0.01) in UAMS-32P cells; in the co-culture system of UAMS-32P cells and mouse primary femur bone marrow cells, PTH (1-34)-(RKK-QEL) stimulated the formation of osteoclasts (P < 0.01) and had a higher biological activity than PTH (1-34) standard reagents.
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50 CFR 86.134 - What if I am already carrying out a plan?
Code of Federal Regulations, 2010 CFR
2010-10-01
... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What if I am already carrying out a plan? 86.134 Section 86.134 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF... INFRASTRUCTURE GRANT (BIG) PROGRAM How States Will Complete the State Program Plans § 86.134 What if I am already...
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A novel one-pot solvent free synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles by condensation of acid hydrazide and triethyl orthoalkanates under microwave irradiations is reported. This green protocol was catalyzed efficiently by solid supported Nafion®NR50 and phosphorus p...
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19 CFR 134.23 - Containers or holders designed for or capable of reuse.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Containers or holders designed for or capable of reuse. 134.23 Section 134.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Marking of Containers or Holders § 134.23 Containers or holders designed for or...
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Nagamata, Satoshi; Nagasaka, Miwako; Kawabata, Akiko; Kishimoto, Kenji; Hasegawa, Daiichiro; Kosaka, Yoshiyuki; Mori, Takeshi; Morioka, Ichiro; Nishimura, Noriyuki; Iijima, Kazumoto; Yamada, Hideto; Kawamoto, Shinichiro; Yakushijin, Kimikazu; Matsuoka, Hiroshi; Mori, Yasuko
2018-05-01
CD134 (OX40), which is a cellular receptor for human herpesvirus-6B (HHV-6B) and expresses on activated T cells, may play a key role for HHV-6B replication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Therefore, we examined the CD134 expression on T cells and HHV-6B replication after allo-HSCT, and analyzed the correlation between them. Twenty-three patients after allo-HSCT were enrolled. The percentages of CD134-positive cells within the CD4 + and CD8 + cell populations were measured by flow cytometry, and the viral copy number of HHV-6B was simultaneously quantified by real-time PCR. The correlation between CD134 and HHV-6B viral load was then statistically analyzed. HHV-6B reactivation occurred in 11 of 23 patients (47.8%). CD134 expression was seen on T cells and was coincident with the time of peak viral load. The percentage of CD134-positive cells decreased significantly when HHV-6B DNA disappeared (p = .005 in CD4 + T cells, p = .02 in CD8 + T cells). In the 4 patients who underwent umbilical cord blood transplantation (UCBT), the viral load varied with the percentage of CD134-positive cells. In the comparison between the HHV-6B reactivation group and non-reactivation group, maximum percentages of CD134-positive cells among CD4 + T cells in reactivation group were significantly higher than those in non-reactivation group (p = .04). This is the first study to show that a correlation of CD134 expression on T cells with HHV-6B replication after allo-HSCT, especially in UCBT. The results possibly indicate that CD134 on T cells plays a key role for HHV-6B replication after allo-HSCT. Copyright © 2018 Elsevier B.V. All rights reserved.
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Johnson, Jennifer L; He, Jing; Ramadass, Mahalakshmi; Pestonjamasp, Kersi; Kiosses, William B; Zhang, Jinzhong; Catz, Sergio D
2016-02-12
The small GTPase Rab11 and its effectors control trafficking of recycling endosomes, receptor replenishment and the up-regulation of adhesion and adaptor molecules at the plasma membrane. Despite recent advances in the understanding of Rab11-regulated mechanisms, the final steps mediating docking and fusion of Rab11-positive vesicles at the plasma membrane are not fully understood. Munc13-4 is a docking factor proposed to regulate fusion through interactions with SNAREs. In hematopoietic cells, including neutrophils, Munc13-4 regulates exocytosis in a Rab27a-dependent manner, but its possible regulation of other GTPases has not been explored in detail. Here, we show that Munc13-4 binds to Rab11 and regulates the trafficking of Rab11-containing vesicles. Using a novel Time-resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay, we demonstrate that Munc13-4 binds to Rab11a but not to dominant negative Rab11a. Immunoprecipitation analysis confirmed the specificity of the interaction between Munc13-4 and Rab11, and super-resolution microscopy studies support the interaction of endogenous Munc13-4 with Rab11 at the single molecule level in neutrophils. Vesicular dynamic analysis shows the common spatio-temporal distribution of Munc13-4 and Rab11, while expression of a calcium binding-deficient mutant of Munc13-4 significantly affected Rab11 trafficking. Munc13-4-deficient neutrophils showed normal endocytosis, but the trafficking, up-regulation, and retention of Rab11-positive vesicles at the plasma membrane was significantly impaired. This correlated with deficient NADPH oxidase activation at the plasma membrane in response to Rab11 interference. Our data demonstrate that Munc13-4 is a Rab11-binding partner that regulates the final steps of Rab11-positive vesicle docking at the plasma membrane. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
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Dai, M-W; Chu, J-G; Tian, F-M; Song, H-P; Wang, Y; Zhang, Y-Z; Zhang, L
2016-06-01
To evaluate the effects of PTH(1-34) on cartilage, subchondral bone mass and structure in medial meniscectomized guinea pigs and compare them to those of celecoxib (CLX). Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations. One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group. All animals were euthanized 12 weeks later, cartilage degeneration and subchondral bone micro-architecture was analyzed. OARSI scores indicated cartilage degeneration was partially inhibited by either CLX or PTH(1-34). Cartilage was significantly thicker in PTH(1-34)-treated animals than in CLX-treated animals. Both CLX and PTH(1-34) treatment were associated with lower ADAMTS-4 and periostin expression than MNX. MMP-13 expression in PTH(1-34) group was significantly lower than that in CLX group. However, AGG expression and the ratio of Col-II/MMP-13 expression in PTH(1-34) group were significantly higher than in the CLX group. Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group. Both CLX and PTH(1-34) exhibits protective effects on cartilage degeneration in meniscectomized guinea pigs. However, PTH(1-34) exhibited superior performance to CLX not only in metabolism of cartilage tissue but also in maintenance of subchondral bone micro-architecture. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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Takahashi, S; Seki, Y; Uchida, A; Nakayama, K; Satoh, H
2015-05-01
Non-photosynthetic and hydrophilic chlorophyll (Chl) proteins, called water-soluble Chl-binding proteins (WSCPs), are distributed in various species of Chenopodiaceae, Amaranthaceae, Polygonaceae and Brassicaceae. Based on their photoconvertibility, WSCPs are categorised into two classes: Class I (photoconvertible) and Class II (non-photoconvertible). Chenopodium album WSCP (CaWSCP; Class I) is able to convert the chlorin skeleton of Chl a into a bacteriochlorin-like skeleton under light in the presence of molecular oxygen. Potassium iodide (KI) is a strong inhibitor of the photoconversion. Because KI attacks tyrosine residues in proteins, tyrosine residues in CaWSCP are considered to be important amino acid residues for the photoconversion. Recently, we identified the gene encoding CaWSCP and found that the mature region of CaWSCP contained four tyrosine residues: Tyr13, Tyr14, Tyr87 and Tyr134. To gain insight into the effect of the tyrosine residues on the photoconversion, we constructed 15 mutant proteins (Y13A, Y14A, Y87A, Y134A, Y13-14A, Y13-87A, Y13-134A, Y14-87A, Y14-134A, Y87-134A, Y13-14-87A, Y13-14-134A, Y13-87-134A, Y14-87-134A and Y13-14-87-134A) using site-directed mutagenesis. Amazingly, all the mutant proteins retained not only chlorophyll-binding activity, but also photoconvertibility. Furthermore, we found that KI strongly inhibited the photoconversion of Y13-14-87-134A. These findings indicated that the four tyrosine residues are not essential for the photoconversion. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.
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Chi, Wenying; Meng, Fanjun; Li, Yan; Li, Peilong; Wang, Guizhi; Cheng, Hong; Han, Song; Li, Junfa
2014-12-10
As a newly discovered member of the HSP70 family, heat shock protein A12B (HSPA12B) is involved in brain ischemic injury. According to our previous study, microRNA-134 (miR-134) could target HSPA12B by binding to its 3'-untranslated region (UTR). However, the regulation of miR-134 on HSPA12B and their role in protecting neuronal cells from ischemic injury are unclear. In this study, the miR-134 expression level was manipulated, and the HSPA12B protein levels were also determined in oxygen-glucose deprivation (OGD)-treated primary cultured neuronal cells in vitro and mouse brain after middle cerebral artery occlusion (MCAO)-induced ischemic stroke in vivo. The results showed that miR-134 expression levels increased in primary cultured neuronal cells and mouse brain from 12h to 7 day reoxygenation/reperfusion after 1h OGD or 1h MCAO treatment. miR-134 overexpression promoted neuronal cell death and apoptosis by decreasing HSPA12B protein levels. Conversely, downregulating miR-134 reduced neuronal cell death and apoptosis by enhancing HSPA12B protein levels. Also, HSPA12B siRNA could block miR-134 inhibitor-mediated neuroprotection against OGD-induced neuronal cell injury in vitro. Taken together, miR-134 might influence neuronal cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by negatively modulating HSPA12B protein expression in a posttranscriptional manner. Copyright © 2014 Elsevier B.V. All rights reserved.
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Meng, Fanjun; Li, Yan; Chi, Wenying; Li, Junfa
2016-07-01
Brain protection by narcotics such as morphine is clinically relevant due to the extensive use of narcotics in the perioperative period. Morphine preconditioning induces neuroprotection in neurons, but it remains uncertain whether microRNA-134 (miR-134) is involved in morphine preconditioning against oxygen-glucose deprivation-induced injuries in primary cortical neurons of mice. The present study examined this issue. After cortical neurons of mice were cultured in vitro for 6 days, the neurons were transfected by respective virus vector, such as lentiviral vector (LV)-miR-control-GFP, LV-pre-miR-134-GFP, LV-pre-miR-134-inhibitor-GFP for 24 hours; after being normally cultured for 3 days again, morphine preconditioning was performed by incubating the transfected primary neurons with morphine (3 μM) for 1 hour, and then neuronal cells were exposed to oxygen-glucose deprivation (OGD) for 1 hour and oxygen-glucose recovery for 12 hours. The neuronal cells survival rate and the amount of apoptotic neurons were determined by MTT assay or TUNEL staining at designated time; and the expression levels of miR-134 were detected using real-time reverse transcription polymerase chain reaction at the same time. The neuronal cell survival rate was significantly higher, and the amount of apoptotic neurons was significantly decreased in neurons preconditioned with morphine before OGD than that of OGD alone. The neuroprotection induced by morphine preconditioning was partially blocked by upregulating miR-134 expression, and was enhanced by downregulating miR-134 expression. The expression of miR-134 was significantly decreased in morphine-preconditioned neurons alone without transfection. By downregulating miR-134 expression, morphine preconditioning protects primary cortical neurons of mice against injuries induced by OGD.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-07
... is available on the Exchange's Web site at http://www.nsx.com , at the principal office of the...: Midpoint Peg x 500 (Auto-Ex mode/Dark) 134.50 x 400 (Order Delivery mode) 134.50 x 200 (Auto-Ex mode... shares priced at 134.50 would execute against the Midpoint Peg Dark Auto-Ex order of 500 shares at 134...
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Modeling and design of a high efficiency hybrid heat pump clothes dryer
DOE Office of Scientific and Technical Information (OSTI.GOV)
TeGrotenhuis, Ward; Butterfield, Andrew; Caldwell, Dustin
Computational modeling is used to design a hybrid heat pump clothes dryer capable of saving 50% of the energy used by residential clothes dryers with comparable drying times. The model represents the various stages of a drying cycle from warm-up through constant drying rate and falling drying rate phases and finishing with a cooldown phase. The model is fit to data acquired from a U.S. commercial standard vented electric dryer, and when a hybrid heat pump system is added, the energy factor increases from 3.0 lbs/kWh to 5.7-6.0 lbs/kWh, depending on the increase in blower motor power. The hybrid heatmore » pump system is designed from off-the-shelf components and includes a recuperative heat exchanger, an electric element, and an R-134a vapor compression heat pump. Parametric studies of element power and heating element use show a trade-off between energy savings and cycle time. Results show a step-change in energy savings from heat pump dryers currently marketed in the U.S. based on performance represented by Enery Star from standardized DOE testing.« less
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Massas, I; Skarlou, V; Haidouti, C; Giannakopoulou, F
2010-03-01
Three rates of Ca(OH)(2) were applied to an acid soil and the (134)Cs uptake by radish, cucumber, soybean and sunflower plants was studied. The (134)Cs concentration in all plant species was reduced from 1.6-fold in the sunflower seeds to 6-fold in the soybean vegetative parts at the higher Ca(OH)(2) rate. Potassium (K) concentration in plants was also reduced, but less effectively. The significantly decreased (134)Cs-K soil to plant distribution factors (D.F.) clearly suggest a stronger effect of soil liming on (134)Cs than on K plant uptake. This observation was discussed in terms of ionic interactions in the soil matrix and within the plants. The results also indicated that the increased Ca(2+) concentration in the exchange phase and in the soil solution along with the improved root activity, due to the soil liming, enhanced the immobilization of (134)Cs in the soil matrix and consequently lowered the (134)Cs availability for plant uptake. 2009 Elsevier Ltd. All rights reserved.
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Kirby, S. M.; Smith, J.; Ventresca, G. P.
1995-01-01
BACKGROUND--Metered dose inhalers for the treatment of asthma use chlorofluorocarbons as propellants. These face an international ban due to their effect on the ozone layer. Salmeterol has been reformulated using the non-chlorinated propellant Glaxo inhalation grade HFA134a. METHODS--The safety, tolerability and systemic pharmacodynamic activity of the salmeterol/HFA134a inhaler, the current salmeterol inhaler, and placebo (HFA134a) were compared in 12 healthy volunteers in a double blind, randomised crossover study using a cumulative dosing design. RESULTS--Safety and tolerability were similar and the response was related to the dose over the range used (50-400 micrograms) with both salmeterol inhalers. The salmeterol/HFA134a inhaler showed no differences from the current inhaler for pulse rate, blood pressure, tremor, QTc interval, and plasma glucose levels. The salmeterol/HFA134a inhaler had significantly less effect on plasma potassium levels. CONCLUSIONS--In healthy volunteers the salmeterol/HFA134a inhaler is at least as safe and well tolerated as the current salmeterol inhaler, and has similar systemic pharmacodynamic activity. PMID:7638815
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Code of Federal Regulations, 2013 CFR
2013-01-01
... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Who can file a response to an appeal petition and when must such a response be filed? 134.510 Section 134.510 Business Credit and... § 134.510 Who can file a response to an appeal petition and when must such a response be filed? Although...
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D'Amato, Marilena; Turrini, Aida; Aureli, Federica; Moracci, Gabriele; Raggi, Andrea; Chiaravalle, Eugenio; Mangiacotti, Michele; Cenci, Telemaco; Orletti, Roberta; Candela, Loredana; di Sandro, Alessandra; Cubadda, Francesco
2013-01-01
This article presents the methodology of the Italian Total Diet Study 2012-2014 aimed at assessing the dietary exposure of the general Italian population to selected nonessential trace elements (Al, inorganic As, Cd, Pb, methyl-Hg, inorganic Hg, U) and radionuclides (40K, 134Cs, 137Cs, 90Sr). The establishment of the TDS food list, the design of the sampling plan, and details about the collection of food samples, their standardized culinary treatment, pooling into analytical samples and subsequent sample treatment are described. Analytical techniques and quality assurance are discussed, with emphasis on the need for speciation data and for minimizing the percentage of left-censored data so as to reduce uncertainties in exposure assessment. Finally the methodology for estimating the exposure of the general population and of population subgroups according to age (children, teenagers, adults, and the elderly) and gender, both at the national level and for each of the four main geographical areas of Italy, is presented.
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NASA Astrophysics Data System (ADS)
Adelman, Saul J.
1991-09-01
This paper presents elemental abundance analyses of sharp-lined normal late B stars. These stars exhibit mostly near-solar abundances, but each star also shows a few abundances which are a factor of 2 less than solar. The coadded photographic spectrograms are supplemented with Reticon data. A comparison of 261 equivalent widths on 2.4 A/mm spectra of sharp-lined B and A stars shows that the Reticon equivalent widths are about 95 percent of the coadded equivalent mean. The H-gamma profiles of the coadded and Reticon spectra for eight sharp-lined stars show generally good agreement. The generally high quality of the coadded data produced from 10 or more spectrograms is confirmed using the REDUCE graphics-oriented computed reduction code. For five stars, metal lines which fall in the gap between the U and V plates are analyzed using Reticon data.
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NASA Technical Reports Server (NTRS)
Adelman, Saul J.
1991-01-01
This paper presents elemental abundance analyses of sharp-lined normal late B stars. These stars exhibit mostly near-solar abundances, but each star also shows a few abundances which are a factor of 2 less than solar. The coadded photographic spectrograms are supplemented with Reticon data. A comparison of 261 equivalent widths on 2.4 A/mm spectra of sharp-lined B and A stars shows that the Reticon equivalent widths are about 95 percent of the coadded equivalent mean. The H-gamma profiles of the coadded and Reticon spectra for eight sharp-lined stars show generally good agreement. The generally high quality of the coadded data produced from 10 or more spectrograms is confirmed using the REDUCE graphics-oriented computed reduction code. For five stars, metal lines which fall in the gap between the U and V plates are analyzed using Reticon data.
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Investigation of two-phase thermosyphon performance filled with modern HFC refrigerants
NASA Astrophysics Data System (ADS)
Gorecki, Grzegorz
2018-02-01
Two-phase closed thermosyphons (TPCTs) are widely utilized as heat exchanger elements in waste heat recovery systems and as passive heating/cooling devices. They are popular because of their high thermal conductivity, simple construction and reliability. Previous researches indicate that refrigerants are performing better than typical TPCT working fluids like deionized water or alcohols in the low temperature range. In the present study three HFC (Hydrofluorocarbons) refrigerants were tested: R134a, R404A and R407C. The total length of the investigated TPCT is 550 mm with equal length (245 mm) condenser and evaporator sections. Its outer diameter is 22 mm with 1 mm wall thickness. The evaporator section was heated by hot water with varying inlet temperature by 5 K step in the range of 288 K - 323 K. The condenser was cooled by cold water with inlet temperature kept at a constant value of 283 K. It was found that using R134a and R404A as working fluids heat transfer rates are the highest. For both refrigerants 10% is optimal filling ratio. They can be utilized interchangeably because the differences between their throughputs are within uncertainty bands. R407C performance was 50% lower. Other disadvantages of using this refrigerant are relatively high working pressures and higher optimal filling ratio (30%).
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Investigation of two-phase thermosyphon performance filled with modern HFC refrigerants
NASA Astrophysics Data System (ADS)
Gorecki, Grzegorz
2018-07-01
Two-phase closed thermosyphons (TPCTs) are widely utilized as heat exchanger elements in waste heat recovery systems and as passive heating/cooling devices. They are popular because of their high thermal conductivity, simple construction and reliability. Previous researches indicate that refrigerants are performing better than typical TPCT working fluids like deionized water or alcohols in the low temperature range. In the present study three HFC (Hydrofluorocarbons) refrigerants were tested: R134a, R404A and R407C. The total length of the investigated TPCT is 550 mm with equal length (245 mm) condenser and evaporator sections. Its outer diameter is 22 mm with 1 mm wall thickness. The evaporator section was heated by hot water with varying inlet temperature by 5 K step in the range of 288 K - 323 K. The condenser was cooled by cold water with inlet temperature kept at a constant value of 283 K. It was found that using R134a and R404A as working fluids heat transfer rates are the highest. For both refrigerants 10% is optimal filling ratio. They can be utilized interchangeably because the differences between their throughputs are within uncertainty bands. R407C performance was 50% lower. Other disadvantages of using this refrigerant are relatively high working pressures and higher optimal filling ratio (30%).
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HFC-134a emissions from mobile air conditioning in China from 1995 to 2030
NASA Astrophysics Data System (ADS)
Su, Shenshen; Fang, Xuekun; Li, Li; Wu, Jing; Zhang, Jianbo; Xu, Weiguang; Hu, Jianxin
2015-02-01
Since 1995, 1,1,1,2-tetrafluoroethane (CH2FCF3, HFC-134a) has become the most important substitute of CFC-12 in mobile air conditioning (MAC) in China and MAC sector has dominated all the emissions of HFC-134a. In this study, we developed an accurate, updated and county-level inventory of the HFC-134a emissions from MAC in China for the period of 1995-2030 with an improved bottom-up method. Our estimation indicated that the total HFC-134a emissions kept growing at increase rates of ∼100% per year for 1995-2000 and ∼34% per year for 2001-2010. In 2010, HFC-134a emissions from MAC in China reached 16.7 Gg (10.5-22.7 Gg at 95% confidential interval), equivalent to 21.7 Tg CO2 (CO2-eq). Furthermore, the emissions in China estimated in this study accounted for 9.8% of global HFC-134a emissions and 29.0% of total emissions from Non-Annex_I countries in 2010. Due to the more advanced social-economic conditions and more intensive ownership of automobiles, greater HFC-134a were observed to come from big cities in East China. Under a Business-as-usual (BAU) Scenario, projected emissions will grow to 89.4 (57.9-123.9) Gg (about 75.3-161.1 Tg CO2-eq) in 2030, but under an Alternative Scenario, 88.6% of the projected emissions under BAU scenario could be curbed. Our estimation demonstrates huge emission mitigation potential of HFC-134a in China's MAC sector.
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STS-134 MS Chamitoff reads a Procedures Checklist
2011-05-30
S134-E-010904 (30 May 2011) --- NASA astronaut Greg Chamitoff, STS-134 mission specialist, reads a procedures checklist while working on the aft flight deck of space shuttle Endeavour during flight day 15 activities. Photo credit: NASA
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Gafni, Rachel I; Guthrie, Lori C; Kelly, Marilyn H; Brillante, Beth A; Christie, C Michele; Reynolds, James C; Yovetich, Nancy A; James, Robert; Collins, Michael T
2015-11-01
Synthetic human PTH 1-34 (hPTH 1-34) replacement therapy in hypoparathyroidism maintains eucalcemia and converts quiescent bone to high-turnover bone. However, the skeletal and metabolic effects of drug discontinuation have not been reported. Nine subjects with hypoparathyroidism received subcutaneous injections of hPTH 1-34 two to three times daily for 19.8 to 61.3 months and then transitioned back to calcium and calcitriol. Biochemistries and bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) were assessed at baseline, while on treatment, and at follow-up 3 to 12 months after drug discontinuation. Two subjects developed hypocalcemia when hPTH 1-34 was abruptly discontinued. Thus, to avoid hypocalcemia, subjects were slowly weaned from hPTH 1-34 over several weeks. When hPTH 1-34 was stopped, subjects were requiring two to three times pretreatment doses of calcitriol and calcium to maintain blood calcium levels. Doses were gradually reduced over many weeks until calcium levels were stable on doses similar to baseline. Bone-specific alkaline phosphatase (BSAP), N-telopeptide (NTX), and osteocalcin (OC) increased significantly with hPTH 1-34; at follow-up, BSAP and NTX had returned to baseline while OC was still slightly elevated. During treatment, BMD was unchanged at the hip and lateral spine but declined at the anterior-posterior (AP) spine, radius, and total body. During weaning, BMD increased, with the hip and lateral spine exceeding pre-hPTH 1-34 values and the whole body returning to baseline. AP spine was increased non-significantly compared to baseline at follow-up. hPTH 1-34 must be gradually weaned in hypoparathyroid patients with high doses of oral medications given to avoid hypocalcemia. The transient increased requirements accompanied by increased BMD after long-term hPTH 1-34 therapy suggest a reversal of the expanded remodeling space favoring bone formation as the skeleton returns to a low-turnover state, reminiscent of the hungry bone syndrome. Further study and close monitoring is required to ensure safe transition to conventional therapy and to elucidate the physiological mechanism of this phenomenon. © 2015 American Society for Bone and Mineral Research.
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R-134a emissions from vehicles.
Siegl, W O; Wallington, T J; Guenther, M T; Henney, T; Pawlak, D; Duffy, M
2002-02-15
We report the first study of R-134a (also known as HFC-134a and CF3CFH2) refrigerant leakage from air conditioning (AC) systems of modern vehicles. Twenty-eight light duty vehicles from five manufacturers (Ford, Toyota, Daimler Chrysler, General Motors, and Honda) were tested according to the USEPA (Federal) extended diurnal test procedure using the Sealed Housing for Evaporative Determination (SHED) apparatus. All tests were conducted using stationary vehicles with the motor and air conditioning system turned off. R-134a was measured using gas chromatography (GC) with a flame ionization detector (FID). All vehicles exhibited measurable R-134a leakage over the 2-day diurnal test. Leak rates of R-134a ranged from 0.01 to 0.36 g/day with an average of 0.07+/-0.07 g/day. When combined with leakage associated with vehicle operation, servicing, and disposal we estimate that the lifetime average R-134a emission rate from an AC equipped vehicle is 0.41+/-0.27 g/day (the majority of emissions are associated with vehicle servicing and disposal). Assuming that the average vehicle travels 10 000 miles per year we estimate that the global warming impact of R-134a leakage from an AC equipped vehicle is approximately 4-5% of that of the CO2 emitted by the vehicle. The results are discussed with respect to the contribution of vehicle emissions to global climate change.
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Nishitani, Kohei; Mietus, Zachary; Beck, Christopher A; Ito, Hiromu; Matsuda, Shuichi; Awad, Hani A; Ehrhart, Nicole; Schwarz, Edward M
2017-01-01
Small animal studies have demonstrated significant high-dose recombinant parathyroid hormone1-34 (rPTH1-34) effects on intercalary allograft healing. Towards a human adjuvant therapy to decrease non-unions, we evaluated rPTH1-34 safety and efficacy in a clinically relevant canine femoral allograft model. Adult female mongrel hounds (n = 20) received a 5cm mid-diaphyseal osteotomy reconstructed with a plated allograft, and were randomized to: 1) Placebo (n = 5; daily saline), 2) Continuous rPTH1-34 (n = 7; 5 μg/kg/day s.c. from day 1-55 post-op), or 3) Delayed rPTH1-34 (n = 8; 5 μg/kg/day s.c. from day 14-28 post-op). Safety was assessed by physical behavior and blood calcium monitoring. Cone beam CT (CB-CT) was performed on days 14, 28 and 56 post-op to assess 2D cortical healing, 3D bone volume, and Union Ratio. Biomechanical testing and dynamic histomorphometry were also performed. The high drug dose was poorly tolerated, as most dogs receiving rPTH1-34 had to be given intravenous saline, and one dog died from hypercalcemia. Continuous rPTH1-34 significantly increased 2D healing and callus volumes at 4-weeks versus Placebo, and sustained the significant increase in cortical union at 8-week (p<0.05). These rPTH1-34 effects were confirmed by histomorphometry, revealing significant increases in mineral apposition rates (MAR) on host bone and graft-host junctions (p<0.05). Delayed rPTH1-34 significantly increased callus volume and MAR at 8 weeks (p<0.05). Although no biomechanical differences were observed, as expected for early healing, the results demonstrated that 2D RUST scoring significantly correlated with torsional biomechanics (p<0.01). In conclusion, 8-weeks of intermittent high-dose rPTH1-34 treatment significantly increases callus formation and accelerates bony union of intercalary massive allografts in a clinically relevant canine model, but with serious side-effects from hypercalcemia.
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Mietus, Zachary; Beck, Christopher A.; Ito, Hiromu; Matsuda, Shuichi; Awad, Hani A.; Ehrhart, Nicole; Schwarz, Edward M.
2017-01-01
Small animal studies have demonstrated significant high-dose recombinant parathyroid hormone1-34 (rPTH1-34) effects on intercalary allograft healing. Towards a human adjuvant therapy to decrease non-unions, we evaluated rPTH1-34 safety and efficacy in a clinically relevant canine femoral allograft model. Adult female mongrel hounds (n = 20) received a 5cm mid-diaphyseal osteotomy reconstructed with a plated allograft, and were randomized to: 1) Placebo (n = 5; daily saline), 2) Continuous rPTH1-34 (n = 7; 5 μg/kg/day s.c. from day 1–55 post-op), or 3) Delayed rPTH1-34 (n = 8; 5 μg/kg/day s.c. from day 14–28 post-op). Safety was assessed by physical behavior and blood calcium monitoring. Cone beam CT (CB-CT) was performed on days 14, 28 and 56 post-op to assess 2D cortical healing, 3D bone volume, and Union Ratio. Biomechanical testing and dynamic histomorphometry were also performed. The high drug dose was poorly tolerated, as most dogs receiving rPTH1-34 had to be given intravenous saline, and one dog died from hypercalcemia. Continuous rPTH1-34 significantly increased 2D healing and callus volumes at 4-weeks versus Placebo, and sustained the significant increase in cortical union at 8-week (p<0.05). These rPTH1-34 effects were confirmed by histomorphometry, revealing significant increases in mineral apposition rates (MAR) on host bone and graft-host junctions (p<0.05). Delayed rPTH1-34 significantly increased callus volume and MAR at 8 weeks (p<0.05). Although no biomechanical differences were observed, as expected for early healing, the results demonstrated that 2D RUST scoring significantly correlated with torsional biomechanics (p<0.01). In conclusion, 8-weeks of intermittent high-dose rPTH1-34 treatment significantly increases callus formation and accelerates bony union of intercalary massive allografts in a clinically relevant canine model, but with serious side-effects from hypercalcemia. PMID:29020057
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40 CFR 35.134 - Eligible recipients.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Eligible recipients. 35.134 Section 35.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... recipients. (a) Eligible agencies. All State agencies (including environmental, health, agriculture, and...
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Fitzpatrick, Faith A.; Arnold, Terri L.; Colman, John A.
1998-01-01
Geochemical data for the upper Illinois River Basin are presented for concentrations of 39 elements in streambed sediment collected by the U.S. Geological Survey in the fall of 1987. These data were collected as part of the pilot phase of the National Water-Quality Assessment Program. A total of 372 sites were sampled, with 238 sites located on first- and second-order streams, and 134 sites located on main stems. Spatial distribution maps and exceedance probability plots are presented for aluminum, antimony, arsenic, barium, beryllium, boron, cadmium, calcium, carbon (total, inorganic, and organic), cerium, chromium, cobalt, copper, gallium, iron, lanthanum, lead, lithium, magnesium, manganese, mercury, molybdenum, neodymium, nickel, niobium, phosphorus, potassium, scandium, selenium, silver, sodium, strontium, sulfur, thorium, titanium, uranium, vanadium, yttrium, and zinc. For spatial distribution maps, concentrations of the elements are grouped into four ranges bounded by the minimum concentration, the 10th, 50th, and 90th percentiles, and the maximum concentrations. These ranges were selected to highlight streambed sediment with very low or very high element concentrations relative to the rest of the streambed sediment in the upper Illinois River Basin. Exceedance probability plots for each element display the differences, if any, in distributions between high- and low-order streams and may be helpful in determining differences between background and elevated concentrations.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Endo, T.; Sato, S.; Yamamoto, A.
2012-07-01
Average burnup of damaged fuels loaded in Fukushima Dai-ichi reactors is estimated, using the {sup 134}Cs/{sup 137}Cs ratio method for measured radioactivities of {sup 134}Cs and {sup 137}Cs in contaminated soils within the range of 100 km from the Fukushima Dai-ichi nuclear power plants. As a result, the measured {sup 134}Cs/{sup 137}Cs ratio from the contaminated soil is 0.996{+-}0.07 as of March 11, 2011. Based on the {sup 134}Cs/{sup 137}Cs ratio method, the estimated burnup of damaged fuels is approximately 17.2{+-}1.5 [GWd/tHM]. It is noted that the numerical results of various calculation codes (SRAC2006/PIJ, SCALE6.0/TRITON, and MVP-BURN) are almost themore » same evaluation values of {sup 134}Cs/ {sup 137}Cs ratio with same evaluated nuclear data library (ENDF-B/VII.0). The void fraction effect in depletion calculation has a major impact on {sup 134}Cs/{sup 137}Cs ratio compared with the differences between JENDL-4.0 and ENDF-B/VII.0. (authors)« less
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Sezer, Narin; Kocaoğlan, Hasan Oğuz; Kılıç, Önder; Lacoue-Labarthe, Thomas; Belivermiş, Murat
2018-04-01
The pH of seawater around the world is expected to continue its decline in the near future in response to ocean acidification that is driven by heightened atmospheric CO 2 emissions. Concomitantly, economically-important molluscs that live in coastal waters including estuaries and embayments, may be exposed to a wide assortment of contaminants, including trace metals and radionuclides. Seawater acidification may alter both the chemical speciation of select elements as well as the physiology of organisms, and may thus pose at risk to many shellfish species, including the manila clam Ruditapes philippinarum. The bioconcentration efficiency of two common radionuclides associated with the nuclear fuel cycle, 134 Cs and 57 Co, were investigated by exposing live clams to dissolved 134 Cs and 57 Co at control (pH = 8.1) and two lowered pH (pH = 7.8 and 7.5) levels using controlled aquaria. The uptake and depuration kinetics of the two radionuclides in the whole-body clam were followed for 21 and 35 days, respectively. At steady-state equilibrium, the concentration factor (CF ss ) for 57 Co increased as the pH decreased (i.e. 130 ± 5, 194 ± 6, and 258 ± 10 at pH levels 8.1, 7.8 and 7.5, respectively), whereas the 134 Cs uptake was not influenced by a change in pH conditions. During depuration, the lowest depuration rate constant of 57 Co by the manila clam was observed at the intermediate pH of 7.8. An increase in the accumulation of 57 Co at the intermediate pH value was thought to be caused mainly by the aragonitic shell of the clam, as well as the low salinity and alkalinity of seawater used in the experiment. Considering that accumulation consists of uptake and depuration, among the three pH conditions moderately acidified seawater enhanced most the accumulation of 57 Co. Accumulation of 134 Cs was not strongly influenced by a reduced pH condition, as represented by an analogous uptake constant rate and CF ss in each treatment. Such results suggest that future seawater pH values that are projected to be lower in the next decades, may pose a risk for calcium-bearing organisms such as shellfish. Copyright © 2018. Published by Elsevier Ltd.
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Wongpakaran, Tinakon; Wongpakaran, Nahathai
2012-12-01
Explore how therapist's interpersonal and attachment styles have an impact upon both the therapeutic alliance formed and therapy outcomes. One hundred twenty one outpatients attending for routine psychiatric services were monitored for symptom outcomes, comprising depression, anxiety, and interpersonal problems. Patients were also asked about the level of therapeutic alliance that had been formed, covering goals, tasks, and the bond developed, using the working alliance inventory (WAI). At the same time, the participating therapists reported upon their interpersonal styles by categorizing them into domineering or submissive styles using the IIP-32 questionnaire and their attachment styles by categorizing them into secure or preoccupied styles using the ECR-R. To explore therapist factors such as interpersonal and attachment styles, as well as to establish the presence of gender matching, the working alliance was used as a dependent variable. Multivariate analysis revealed that neither the gender of the therapist nor the gender of the patient, or the therapists' styles, had an effect on the Working alliance or working outcomes. The multivariate test for WAI-goal (Wilks' Lambda F (3, 134) = 4.24, p = 0.007), interpersonal style (Wilks 'Lambda F (3, 134) = 2.77, p = 0.044), attachment style (Wilks' LambdaF (3, 134) = 2. 76, p = 0.045) and IIP-Style*Attachment Style (Wilks' Lambda F (3, 134) = 3.13, p = 0.028) produced statistically significant results, while working alliance-goal was the only predictor of the level of anxiety and depression in patients (p = 0.014 and p = 0.002, respectively). Submissive style was positively correlated to anxiety (p = 0.011) and interpersonal difficulties (p = 0.006), whilst surprisingly, a secure attachment style was found to have a positive correlation with anxiety and depression. However when both styles were combined, the resulting style negatively predicted anxiety (p = 0.002). Therapist factors were found to have no effect on working alliance, as reported by the patients; however, it was reported that when the therapists employed a secure or submissive attachment style, this played a role in helping to reduce symptoms. The working alliance-goal element was found to be a predictor of a reduction in levels of both anxiety and depression among patients.
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7 CFR 58.134 - Sediment content for milk in cans.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 7 Agriculture 3 2014-01-01 2014-01-01 false Sediment content for milk in cans. 58.134 Section 58.134 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS...
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View of STS-134 MS Vittori secured inside his Sleeping Bag
2011-05-16
S134-E-006404 (16 May 2011) --- European Space Agency astronaut Roberto Vittori, STS-134 mission specialist, rests in his sleeping bag, which is attached to the lockers on the middeck of the space shuttle Endeavour. Photo credit: NASA
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13 CFR 134.102 - Jurisdiction of OHA.
Code of Federal Regulations, 2013 CFR
2013-01-01
... SBA Employee Dispute Resolution Process cases (Employee Disputes) under Standard Operating Procedure... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Jurisdiction of OHA. 134.102 Section 134.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... has express authority, under statute, SBA regulation or SBA standard operating procedures, to review... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Settlement. 134.217 Section 134.217 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES...
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13 CFR 134.102 - Jurisdiction of OHA.
Code of Federal Regulations, 2014 CFR
2014-01-01
... SBA Employee Dispute Resolution Process cases (Employee Disputes) under Standard Operating Procedure... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Jurisdiction of OHA. 134.102 Section 134.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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13 CFR 134.102 - Jurisdiction of OHA.
Code of Federal Regulations, 2012 CFR
2012-01-01
... SBA Employee Dispute Resolution Process cases (Employee Disputes) under Standard Operating Procedure... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Jurisdiction of OHA. 134.102 Section 134.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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40 CFR 417.134 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Pretreatment standards for existing sources. 417.134 Section 417.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Chlorosulfonic...
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40 CFR 417.134 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Pretreatment standards for existing sources. 417.134 Section 417.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Chlorosulfonic...
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40 CFR 417.134 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Pretreatment standards for existing sources. 417.134 Section 417.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Chlorosulfonic...
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40 CFR 417.134 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Pretreatment standards for existing sources. 417.134 Section 417.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Chlorosulfonic...
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40 CFR 417.134 - Pretreatment standards for existing sources.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Pretreatment standards for existing sources. 417.134 Section 417.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Chlorosulfonic...
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MicroRNA-134-5p promotes high glucose-induced podocyte apoptosis by targeting bcl-2
Qian, Xiaoxiao; Tan, Juan; Liu, Ling; Chen, Sheng; You, Na; Yong, Huijuan; Pan, Minglin; You, Qiang; Ding, Dafa; Lu, Yibing
2018-01-01
Podocyte apoptosis is a typical early feature of diabetic nephropathy (DN), with loss of nephrin integrity contributing to increased proteinuria in patients with DN. Emerging evidence shows that microRNAs (miRNAs) play vital roles in the pathogenesis of DN. Thus, we aimed to further elucidate the role of miRNAs in podocyte apoptosis in DN. We used db/db and db/m mice maintained under a continuous feeding regime for 12 weeks. Using microarray analysis, we found several miRNAs potentially related to podocyte apoptosis. In addition, we cultured a conditionally immortalized human podocyte cell line in 30 mM D-glucose and found that miR-134-5p was upregulated in both db/db mice and high-glucose (HG)-treated podocytes. Upregulation of miR-134-5p was accompanied by podocyte apoptosis and downregulation of nephrin. Inhibition of miR-134-5p produced the opposite effect. Dual-luciferase reporter assays showed that miR-134-5p directly targeted the 3’-untranslated region of the B-cell lymphoma-2 gene (BCL2), and further study confirmed an increase in bcl-2 protein level in HG-treated podocytes transfected with anti-miR-134-5p. Knockdown of BCL2 impeded the antiapoptotic effect of anti-miR-134-5p. Finally, we found that miR-134-5p might regulate apoptosis in db/db mice and podocytes by targeting BCL2. Taken together, our findings suggest that miR-134-5p promotes podocyte apoptosis under HG conditions by targeting BCL2. Our study provides a meaningful approach to interpret the mechanisms of action of miRNAs involved in DN. PMID:29636888
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Hildreth, Blake Eason; Williams, Michelle M; Dembek, Katarzyna A; Hernon, Krista M; Rosol, Thomas J; Toribio, Ramiro E
2015-12-01
Evidence exists that parathyroid hormone-related protein (PTHrP) 1-34 may be more anabolic in bone than parathyroid hormone 1-34. While optical imaging is growing in popularity, scant information exists on the relationships between traditional bone imaging and histology and bioluminescence (BLI) and fluorescence (FLI) imaging. We aimed to evaluate the effects of PTHrP 1-34 on bone mass and determine if relationships existed between radiographic and histologic findings in bone and BLI and FLI indices. Vertebrae (vossicles) from mice coexpressing luciferase and green fluorescent protein were implanted subcutaneously into allogenic nude mice. Transplant recipients were treated daily with saline or PTHrP 1-34 for 4 weeks. BLI, FLI, radiography, histology, and µCT of the vossicles were performed over time. PTHrP 1-34 increased bioluminescence the most after 2 weeks, fluorescence at all time points, and decreased the time to peak bioluminescence at 4 weeks (P ≤ 0.027), the latter of which suggesting enhanced engraftment. PTHrP 1-34 maximized vertebral body volume at 4 weeks (P < 0.0001). The total amount of bone observed histologically increased in both groups at 2 and 4 weeks (P ≤ 0.002); however, PTHrP 1-34 exceeded time-matched controls (P ≤ 0.044). A positive linear relationship existed between the percentage of trabecular bone and (1) total bioluminescence (r = 0.595; P = 0.019); (2) total fluorescence (r = 0.474; P = 0.074); and (3) max fluorescence (r = 0.587; P = 0.021). In conclusion, PTHrP 1-34 enhances engraftment and bone mass, which can be monitored non-invasively by BLI and FLI.
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Surbrook, S E; Olson, M J
1992-01-01
The chlorofluorocarbon substitute 1,1,1,2-tetrafluoroethane (HFC-134a) is subject to metabolism by cytochrome P-450 in hepatic microsomes from rat, rabbit, and human. In rat and rabbit, the P-450 form 2E1 is a predominant low-KM, high-rate catalyst of HFC-134a biotransformation and is prominently involved in the metabolism of other tetrahaloalkanes of greater toxicity than HFC-134a [e.g. 1,2-dichloro-1,1-difluoroethane (HCFC-132b)]. In this study, we determined that the human ortholog of P-450 2E1 plays a role of similar importance in the metabolism of HFC-134a. In human hepatic microsomes from 12 individuals, preparations from subjects with relatively high P-450 2E1 levels were shown to metabolize HFC-134a at rates 5- to 10-fold greater than microsomes of individuals with lower levels of this enzyme; the increased rate of metabolism of HFC-134a was specifically linked to increased expression of P-450 2E1. The primary evidence for this conclusion is drawn from studies using mechanism-based inactivation of P-450 2E1 by diethyldithiocarbamate, competitive inhibition of HFC-134a oxidation by p-nitrophenol (a high-affinity substrate for P-450 2E1), strong positive correlation of rates of HFC-134a defluorination with p-nitrophenol hydroxylation in the study population, and correlation of P-450 2E1 levels with rates of halocarbon oxidation. Thus, our findings support the conclusion that human metabolism of HFC-134a is qualitatively similar to that of the species (rat and rabbit) used for toxicological assessment of this halocarbon.(ABSTRACT TRUNCATED AT 250 WORDS)
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Itai, Shunsuke; Yamada, Shinji; Kaneko, Mika K; Chang, Yao-Wen; Harada, Hiroyuki; Kato, Yukinari
2017-12-01
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, activates downstream signaling cascades in many tumors. In this study, we established novel anti-EGFR monoclonal antibodies (mAbs) and characterized their efficacy in flow cytometry, Western blot, and immunohistochemical analyses. We immunized mice with a combination of the extracellular domain of EGFR and EGFR-overexpressing LN229 glioblastoma cells (LN229/EGFR) and performed the first screening using enzyme-linked immunosorbent assay. Next, we selected mAbs using flow cytometry. Among 156 established clones, two mAbs, EMab-51 (IgG 1 , kappa) and EMab-134 (IgG 1 , kappa), reacted with EGFR in Western blot analysis; EMab-134 showed a much higher sensitivity compared with EMab-51. We compared the binding affinities of EMab-51 and EMab-134 using flow cytometry; the calculated K D values for EMab-51 and EMab-134 against SAS cells/HSC-2 cells were 9.2 × 10 -9 M/9.9 × 10 -9 M and 2.6 × 10 -9 M/8.3 × 10 -9 M, respectively, indicating that EMab-134 has a higher affinity to EGFR-expressing cells. Immunohistochemical analysis of EMab-51 and EMab-134 showed sensitive and specific reactions against oral cancer cells; EMab-134 demonstrated a much higher sensitivity (36/38 cases; 94.7%) to oral squamous cell carcinomas compared with EMab-51 (6/38 cases; 15.8%). This novel anti-EGFR mAb, EMab-134, could be advantageous for detecting EGFR in the pathological analysis of EGFR-expressing cancers.
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Woo, Sang Su; James, Declan J; Martin, Thomas F J
2017-03-15
Munc13-4 is a Ca 2+ -dependent SNARE (soluble N -ethylmaleimide-sensitive factor attachment protein receptor)- and phospholipid-binding protein that localizes to and primes secretory granules (SGs) for Ca 2+ -evoked secretion in various secretory cells. Studies in mast cell-like RBL-2H3 cells provide direct evidence that Munc13-4 with its two Ca 2+ -binding C2 domains functions as a Ca 2+ sensor for SG exocytosis. Unexpectedly, Ca 2+ stimulation also generated large (>2.4 μm in diameter) Munc13-4 + /Rab7 + /Rab11 + endosomal vacuoles. Vacuole generation involved the homotypic fusion of Munc13-4 + /Rab7 + SGs, followed by a merge with Rab11 + endosomes, and depended on Ca 2+ binding to Munc13-4. Munc13-4 promoted the Ca 2+ -stimulated fusion of VAMP8-containing liposomes with liposomes containing exocytic or endosomal Q-SNAREs and directly interacted with late endosomal SNARE complexes. Thus Munc13-4 is a tethering/priming factor and Ca 2+ sensor for both heterotypic SG-plasma membrane and homotypic SG-SG fusion. Total internal reflection fluorescence microscopy imaging revealed that vacuoles were exocytic and mediated secretion of β-hexosaminidase and cytokines accompanied by Munc13-4 diffusion onto the plasma membrane. The results provide new molecular insights into the mechanism of multigranular compound exocytosis commonly observed in various secretory cells. © 2017 Woo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
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1,3,4-Thiadiazole-based diamides: Synthesis and complexation properties
NASA Astrophysics Data System (ADS)
Łukasik, Natalia; Luboch, Elżbieta; Chojnacki, Jarosław; Wagner-Wysiecka, Ewa
2017-10-01
Aromatic diamides, derivative of 2,6-pyridinedicarboxylic acid and isophthalic acid, bearing 1,3,4-thiadiazole residue were prepared with satisfactory yields in conventional procedures and microwave stimulated reactions. X-ray structure of N,N‧-bis(1,3,4-thiadiazol-2-yl)-2,6-pyridinedicarboxamide (2) DMSO solvate (2·DMSO) was described. Selective zinc(II), lanthanum(III), terbium(III) and L-tyrosine recognition was found for N,N‧-bis(1,3,4-thiadiazol-2-yl)-2,6-pyridinedicarboxamide in DMSO and its mixture with water. The IDA (Indicator Displacement Assay) system for metal cations sensing was proposed. The binding properties of 2 were compared with newly synthesized N,N‧-bis(1,3,4-thiadiazol-2-yl)-1,3-benzenedicarboxamide 1.
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2011-05-16
S134-E-005102 (16 May 2011) --- The STS-134 external fuel tank is seen during its release from space shuttle Endeavour in space following the successful launch on May 16, 2011. An STS-134 crew member using a hand-held still camera exposed the image. Photo credit: NASA
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2011-05-16
S134-E-005085 (16 May 2011) --- The STS-134 external fuel tank is seen during its release from space shuttle Endeavour in space following the successful launch on May 16, 2011. An STS-134 crew member using a hand-held still camera exposed the image. Photo credit: NASA
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2011-05-16
S134-E-005013 (16 May 2011) --- The STS-134 external fuel tank is seen during its release from space shuttle Endeavour in space following the successful launch on May 16, 2011. An STS-134 crew member using a hand-held still camera exposed the image. Photo credit: NASA
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41 CFR 105-53.134 - Office of Administration.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Office of Administration. 105-53.134 Section 105-53.134 Public Contracts and Property Management Federal Property Management... Associate Administrator for Administration, participates in the executive leadership of the agency...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... authority, under statute, SBA regulation or SBA standard operating procedures, to review the contents of a... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Settlement. 134.217 Section 134.217 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES...
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13 CFR 134.102 - Jurisdiction of OHA.
Code of Federal Regulations, 2010 CFR
2010-01-01
... Employee Dispute Resolution Process cases (Employee Disputes) under Standard Operating Procedure 37 71 02... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Jurisdiction of OHA. 134.102 Section 134.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... authority, under statute, SBA regulation or SBA standard operating procedures, to review the contents of a... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Settlement. 134.217 Section 134.217 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES...
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Code of Federal Regulations, 2014 CFR
2014-01-01
... authority, under statute, SBA regulation or SBA standard operating procedures, to review the contents of a... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Settlement. 134.217 Section 134.217 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES...
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Code of Federal Regulations, 2012 CFR
2012-01-01
... authority, under statute, SBA regulation or SBA standard operating procedures, to review the contents of a... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Settlement. 134.217 Section 134.217 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES...
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7 CFR 1221.134 - Personal liability.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 10 2010-01-01 2010-01-01 false Personal liability. 1221.134 Section 1221.134 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... individually or jointly with others, in any way whatsoever, to any person for errors in judgment, mistakes, or...
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Experimental evaluation of automotive air-conditioning using HFC-134a and HC-134a
NASA Astrophysics Data System (ADS)
Nasution, Henry; Zainudin, Muhammad Amir; Aziz, Azhar Abdul; Latiff, Zulkarnain Abdul; Perang, Mohd Rozi Mohd; Rahman, Abd Halim Abdul
2012-06-01
An experimental study to evaluate the energy consumption of an automotive air conditioning is presented. In this study, these refrigerants will be tested using the experimental rig which simulated the actual cars as a cabin complete with a cooling system component of the actual car that is as the blower, evaporator, condenser, radiators, electric motor, which acts as a vehicle engine, and then the electric motor will operate the compressor using a belt and pulley system, as well as to the alternator will recharge the battery. The compressor working with the fluids HFC-134a and HC-134a and has been tested varying the speed in the range 1000, 1500, 2000 and 2500 rpm. The measurements taken during the one hour experimental periods at 2-minutes interval times for temperature setpoint of 20°C with internal heat loads 0, 500, 700 and 1000 W. The final results of this study show an overall better energy consumption of the HFC-134a compared with the HC-134a.
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Elucidation of the critical epitope of an anti-EGFR monoclonal antibody EMab-134.
Kaneko, Mika K; Yamada, Shinji; Itai, Shunsuke; Chang, Yao-Wen; Nakamura, Takuro; Yanaka, Miyuki; Kato, Yukinari
2018-07-01
The epidermal growth factor receptor (EGFR) is a type-1 transmembrane receptor tyrosine kinase, which activates the downstream signaling cascades in many tumors, such as oral and lung cancers. We previously developed EMab-134, a novel anti-EGFR monoclonal antibody (mAb), which reacts with endogenous EGFR-expressing cancer cell lines and normal cells independent of glycosylation in Western blotting, flow cytometry, and immunohistochemical analysis. EMab-134 showed very high sensitivity (94.7%) to oral squamous cell carcinomas in immunohistochemical analysis. In this study, we performed enzyme-linked immunosorbent assay (ELISA), flow cytometry, and immunohistochemical analysis to determine the epitope of EMab-134. A blocking peptide (375-394 amino acids of EGFR) neutralized the EMab-134 reaction against oral cancer cells in flow cytometry and immunohistochemistry. The minimum epitope of EMab-134 was found to be the 377- RGDSFTHTPP -386 sequence. Our findings can be applied for the production of more functional anti-EGFR mAbs that in turn can be used for antitumor treatments.
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Woo, Sang Su; James, Declan J.; Martin, Thomas F. J.
2017-01-01
Munc13-4 is a Ca2+-dependent SNARE (soluble N-ethylmaleimide–sensitive factor attachment protein receptor)- and phospholipid-binding protein that localizes to and primes secretory granules (SGs) for Ca2+-evoked secretion in various secretory cells. Studies in mast cell–like RBL-2H3 cells provide direct evidence that Munc13–4 with its two Ca2+-binding C2 domains functions as a Ca2+ sensor for SG exocytosis. Unexpectedly, Ca2+ stimulation also generated large (>2.4 μm in diameter) Munc13-4+/Rab7+/Rab11+ endosomal vacuoles. Vacuole generation involved the homotypic fusion of Munc13-4+/Rab7+ SGs, followed by a merge with Rab11+ endosomes, and depended on Ca2+ binding to Munc13-4. Munc13-4 promoted the Ca2+-stimulated fusion of VAMP8-containing liposomes with liposomes containing exocytic or endosomal Q-SNAREs and directly interacted with late endosomal SNARE complexes. Thus Munc13-4 is a tethering/priming factor and Ca2+ sensor for both heterotypic SG-plasma membrane and homotypic SG-SG fusion. Total internal reflection fluorescence microscopy imaging revealed that vacuoles were exocytic and mediated secretion of β-hexosaminidase and cytokines accompanied by Munc13-4 diffusion onto the plasma membrane. The results provide new molecular insights into the mechanism of multigranular compound exocytosis commonly observed in various secretory cells. PMID:28100639
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21 CFR 211.134 - Drug product inspection.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drug product inspection. 211.134 Section 211.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Packaging and Labeling Control...
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13 CFR 134.209 - Requirement of signature.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Requirement of signature. 134.209 Section 134.209 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING... of signature. Every written submission to OHA, other than evidence, must be signed by the party...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Other remedies. 13.4 Section 13.4... Other remedies. (a) This regulation does not supersede or require omission or duplication of... a procurement contract. (b) The remedies and sanctions available to the Agency under this regulation...
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Other remedies. 13.4 Section 13.4... Other remedies. (a) This regulation does not supersede or require omission or duplication of... a procurement contract. (b) The remedies and sanctions available to the Agency under this regulation...
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7 CFR 58.134 - Sediment content.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 7 Agriculture 3 2012-01-01 2012-01-01 false Sediment content. 58.134 Section 58.134 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...
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7 CFR 58.134 - Sediment content.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 7 Agriculture 3 2010-01-01 2010-01-01 false Sediment content. 58.134 Section 58.134 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...
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42 CFR 84.134 - Respirator containers; minimum requirements.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 1 2010-10-01 2010-10-01 false Respirator containers; minimum requirements. 84.134... Respirators § 84.134 Respirator containers; minimum requirements. Supplied-air respirators shall be equipped with a substantial, durable container bearing markings which show the applicant's name, the type and...
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7 CFR 58.134 - Sediment content.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 7 Agriculture 3 2011-01-01 2011-01-01 false Sediment content. 58.134 Section 58.134 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE...
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13 CFR 134.801 - Scope of rules.
Code of Federal Regulations, 2013 CFR
2013-01-01
... Dispute Resolution Process (EDRP). Standard Operating Procedure (SOP) 37 71 sets out the EDRP. It is... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Scope of rules. 134.801 Section 134.801 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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13 CFR 134.801 - Scope of rules.
Code of Federal Regulations, 2014 CFR
2014-01-01
... Dispute Resolution Process (EDRP). Standard Operating Procedure (SOP) 37 71 sets out the EDRP. It is... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Scope of rules. 134.801 Section 134.801 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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13 CFR 134.801 - Scope of rules.
Code of Federal Regulations, 2011 CFR
2011-01-01
... Dispute Resolution Process (EDRP). Standard Operating Procedure (SOP) 37 71 sets out the EDRP. It is... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Scope of rules. 134.801 Section 134.801 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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13 CFR 134.801 - Scope of rules.
Code of Federal Regulations, 2012 CFR
2012-01-01
... Dispute Resolution Process (EDRP). Standard Operating Procedure (SOP) 37 71 sets out the EDRP. It is... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Scope of rules. 134.801 Section 134.801 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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Code of Federal Regulations, 2012 CFR
2012-10-01
... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Applicability. 13.4 Section 13.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... expenses under The Food Stamp Act of 1977 (section 16 of the Act). (7) A grant for an experimental, pilot...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-09
... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-42-2013] Foreign-Trade Zone 134--Chattanooga, Tennessee; Authorization of Production Activity; Komatsu America Corporation, (Construction and Forestry Equipment), Chattanooga, Tennessee On May 6, 2013, the Chattanooga Chamber Foundation, grantee of FTZ 134...
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40 CFR 49.134 - Rule for forestry and silvicultural burning permits.
Code of Federal Regulations, 2012 CFR
2012-07-01
... burning permits. 49.134 Section 49.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS... Rule for forestry and silvicultural burning permits. (a) What is the purpose of this section? This section establishes a permitting program for forestry and silvicultural burning within the Indian...
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40 CFR 49.134 - Rule for forestry and silvicultural burning permits.
Code of Federal Regulations, 2013 CFR
2013-07-01
... burning permits. 49.134 Section 49.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS... Rule for forestry and silvicultural burning permits. (a) What is the purpose of this section? This section establishes a permitting program for forestry and silvicultural burning within the Indian...
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40 CFR 49.134 - Rule for forestry and silvicultural burning permits.
Code of Federal Regulations, 2011 CFR
2011-07-01
... burning permits. 49.134 Section 49.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS... Rule for forestry and silvicultural burning permits. (a) What is the purpose of this section? This section establishes a permitting program for forestry and silvicultural burning within the Indian...
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40 CFR 49.134 - Rule for forestry and silvicultural burning permits.
Code of Federal Regulations, 2010 CFR
2010-07-01
... burning permits. 49.134 Section 49.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS... and silvicultural burning permits. (a) What is the purpose of this section? This section establishes a permitting program for forestry and silvicultural burning within the Indian reservation to control emissions...
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40 CFR 49.134 - Rule for forestry and silvicultural burning permits.
Code of Federal Regulations, 2014 CFR
2014-07-01
... burning permits. 49.134 Section 49.134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS... Rule for forestry and silvicultural burning permits. (a) What is the purpose of this section? This section establishes a permitting program for forestry and silvicultural burning within the Indian...
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21 CFR 145.134 - Canned preserved figs.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...
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21 CFR 145.134 - Canned preserved figs.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...
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21 CFR 145.134 - Canned preserved figs.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...
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21 CFR 145.134 - Canned preserved figs.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...
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32 CFR 13.4 - Duties and responsibilities of the defense.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 1 2010-07-01 2010-07-01 false Duties and responsibilities of the defense. 13.4 Section 13.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... be directed by the Appointing Authority or the General Counsel of the Department of Defense. ...
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32 CFR 13.4 - Duties and responsibilities of the defense.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 32 National Defense 1 2011-07-01 2011-07-01 false Duties and responsibilities of the defense. 13.4 Section 13.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... be directed by the Appointing Authority or the General Counsel of the Department of Defense. ...
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32 CFR 13.4 - Duties and responsibilities of the defense.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 32 National Defense 1 2013-07-01 2013-07-01 false Duties and responsibilities of the defense. 13.4 Section 13.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY... be directed by the Appointing Authority or the General Counsel of the Department of Defense. ...
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25 CFR 39.134 - How does a school identify a Limited English Proficient student?
Code of Federal Regulations, 2011 CFR
2011-04-01
... student? 39.134 Section 39.134 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Indian School Equalization Formula Language Development Programs § 39... limited English proficient (LEP) by using a nationally recognized scientifically research-based test. ...
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28 CFR 13.4 - Procedures: Responsibilities of the Attorney General.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Procedures: Responsibilities of the Attorney General. 13.4 Section 13.4 Judicial Administration DEPARTMENT OF JUSTICE ATOMIC WEAPONS AND.... When a submission is made to the Department of Justice for a reward under the Atomic Weapons and...
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28 CFR 13.4 - Procedures: Responsibilities of the Attorney General.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Procedures: Responsibilities of the Attorney General. 13.4 Section 13.4 Judicial Administration DEPARTMENT OF JUSTICE ATOMIC WEAPONS AND.... When a submission is made to the Department of Justice for a reward under the Atomic Weapons and...
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28 CFR 13.4 - Procedures: Responsibilities of the Attorney General.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Procedures: Responsibilities of the Attorney General. 13.4 Section 13.4 Judicial Administration DEPARTMENT OF JUSTICE ATOMIC WEAPONS AND.... When a submission is made to the Department of Justice for a reward under the Atomic Weapons and...
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28 CFR 13.4 - Procedures: Responsibilities of the Attorney General.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Procedures: Responsibilities of the Attorney General. 13.4 Section 13.4 Judicial Administration DEPARTMENT OF JUSTICE ATOMIC WEAPONS AND.... When a submission is made to the Department of Justice for a reward under the Atomic Weapons and...
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28 CFR 13.4 - Procedures: Responsibilities of the Attorney General.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Procedures: Responsibilities of the Attorney General. 13.4 Section 13.4 Judicial Administration DEPARTMENT OF JUSTICE ATOMIC WEAPONS AND.... When a submission is made to the Department of Justice for a reward under the Atomic Weapons and...
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33 CFR 157.134 - Cargo tank drainage.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Cargo tank drainage. 157.134...) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Design, Equipment, and Installation § 157.134 Cargo tank...
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33 CFR 157.134 - Cargo tank drainage.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Cargo tank drainage. 157.134...) POLLUTION RULES FOR THE PROTECTION OF THE MARINE ENVIRONMENT RELATING TO TANK VESSELS CARRYING OIL IN BULK Crude Oil Washing (COW) System on Tank Vessels Design, Equipment, and Installation § 157.134 Cargo tank...
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22 CFR 134.30 - Payment of award.
Code of Federal Regulations, 2010 CFR
2010-04-01
... will pay the amount awarded to the applicant within 60 days, unless judicial review of the award or of... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Payment of award. 134.30 Section 134.30 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS EQUAL ACCESS TO JUSTICE ACT; IMPLEMENTATION Procedures for...
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42 CFR 413.134 - Depreciation: Allowance for depreciation based on asset costs.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 42 Public Health 2 2013-10-01 2013-10-01 false Depreciation: Allowance for depreciation based on asset costs. 413.134 Section 413.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT...
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42 CFR 413.134 - Depreciation: Allowance for depreciation based on asset costs.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 42 Public Health 2 2014-10-01 2014-10-01 false Depreciation: Allowance for depreciation based on asset costs. 413.134 Section 413.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT...
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42 CFR 413.134 - Depreciation: Allowance for depreciation based on asset costs.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 42 Public Health 2 2011-10-01 2011-10-01 false Depreciation: Allowance for depreciation based on asset costs. 413.134 Section 413.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT...
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42 CFR 413.134 - Depreciation: Allowance for depreciation based on asset costs.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 42 Public Health 2 2010-10-01 2010-10-01 false Depreciation: Allowance for depreciation based on asset costs. 413.134 Section 413.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT...
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42 CFR 413.134 - Depreciation: Allowance for depreciation based on asset costs.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 42 Public Health 2 2012-10-01 2012-10-01 false Depreciation: Allowance for depreciation based on asset costs. 413.134 Section 413.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PRINCIPLES OF REASONABLE COST REIMBURSEMENT; PAYMENT...
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19 CFR 134.43 - Methods of marking specific articles.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Methods of marking specific articles. 134.43...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Method and Location of Marking Imported Articles § 134.43 Methods of marking specific articles. (a) Marking previously required by certain provisions of the...
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19 CFR 134.43 - Methods of marking specific articles.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Methods of marking specific articles. 134.43...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Method and Location of Marking Imported Articles § 134.43 Methods of marking specific articles. (a) Marking previously required by certain provisions of the...
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19 CFR 134.43 - Methods of marking specific articles.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 1 2012-04-01 2012-04-01 false Methods of marking specific articles. 134.43...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Method and Location of Marking Imported Articles § 134.43 Methods of marking specific articles. (a) Marking previously required by certain provisions of the...
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36 CFR 13.4 - Information collection.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Information collection. 13.4... NATIONAL PARK SYSTEM UNITS IN ALASKA Administrative Provisions § 13.4 Information collection. The information collection requirements contained in subparts C and G, and §§ 13.55, 13.440, 13.450, 13.485, and...
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21 CFR 133.134 - Cream cheese with other foods.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Cream cheese with other foods. 133.134 Section 133.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized...
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21 CFR 133.134 - Cream cheese with other foods.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Cream cheese with other foods. 133.134 Section 133.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized...
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21 CFR 133.134 - Cream cheese with other foods.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Cream cheese with other foods. 133.134 Section 133.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized...
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13 CFR 134.702 - Who may appeal?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Who may appeal? 134.702 Section 134.702 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women-Owned Small...
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13 CFR 134.711 - Will the Judge permit discovery and oral hearings?
Code of Federal Regulations, 2010 CFR
2010-01-01
... Appeals From Women-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Will the Judge permit discovery and oral hearings? 134.711 Section 134.711 Business Credit and Assistance SMALL BUSINESS...
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13 CFR 134.705 - What are the requirements for an appeal petition?
Code of Federal Regulations, 2010 CFR
2010-01-01
... Appeals From Women-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the requirements for an appeal petition? 134.705 Section 134.705 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION...
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27 CFR 17.134 - Determination of unfitness for beverage purposes.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Determination of unfitness for beverage purposes. 17.134 Section 17.134 Alcohol, Tobacco Products and Firearms ALCOHOL AND... an alcoholic concentration of 15% and tasted. Sale or use for beverage purposes is indicative of...
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13 CFR 134.202 - Commencement of cases.
Code of Federal Regulations, 2010 CFR
2010-01-01
... proceedings, see § 124.305 of this chapter; (5) For SBA Employee Disputes, see Standard Operating Procedure 37... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Commencement of cases. 134.202 Section 134.202 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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13 CFR 134.206 - The answer or response.
Code of Federal Regulations, 2010 CFR
2010-01-01
... Disputes, see Standard Operating Procedure 37 71 02, available at www.sba.gov/library/soproom.html. (2) The... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false The answer or response. 134.206 Section 134.206 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING...
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36 CFR 13.4 - Information collection.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Information collection. 13.4... NATIONAL PARK SYSTEM UNITS IN ALASKA Administrative Provisions § 13.4 Information collection. The information collection requirements contained in subparts C and G, and §§ 13.55, 13.440, 13.450, 13.485, and...
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13 CFR 134.407 - Evidence beyond the record and discovery.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Evidence beyond the record and discovery. 134.407 Section 134.407 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF..., the Administrative Law Judge may not admit evidence beyond the written administrative record nor...
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40 CFR 86.134-96 - Running loss test.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Running loss test. 86.134-96 Section... Heavy-Duty Vehicles; Test Procedures § 86.134-96 Running loss test. (a) Overview. Gasoline- and methanol-fueled vehicles are to be tested for running loss emissions during simulated high-temperature urban...
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40 CFR 86.134-96 - Running loss test.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Running loss test. 86.134-96 Section... Heavy-Duty Vehicles; Test Procedures § 86.134-96 Running loss test. (a) Overview. Gasoline- and methanol-fueled vehicles are to be tested for running loss emissions during simulated high-temperature urban...
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40 CFR 86.134-96 - Running loss test.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Running loss test. 86.134-96 Section... Heavy-Duty Vehicles; Test Procedures § 86.134-96 Running loss test. (a) Overview. Gasoline- and methanol-fueled vehicles are to be tested for running loss emissions during simulated high-temperature urban...
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40 CFR 86.134-96 - Running loss test.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Running loss test. 86.134-96 Section... Heavy-Duty Vehicles; Test Procedures § 86.134-96 Running loss test. (a) Overview. Gasoline- and methanol-fueled vehicles are to be tested for running loss emissions during simulated high-temperature urban...
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9 CFR 381.134 - Requirement of formulas.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Requirement of formulas. 381.134 Section 381.134 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS...
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27 CFR 22.134 - Records of shipment.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Records of shipment. 22.134 Section 22.134 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... § 22.161. (Approved by the Office of Management and Budget under control number 1512-0334) ...
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27 CFR 22.134 - Records of shipment.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Records of shipment. 22.134 Section 22.134 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... § 22.161. (Approved by the Office of Management and Budget under control number 1512-0334) ...
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13 CFR 134.220 - Prohibition against ex parte communications.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Prohibition against ex parte communications. 134.220 Section 134.220 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF....220 Prohibition against ex parte communications. No person shall consult or communicate with a Judge...
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31 CFR 363.134 - What regulations cover a certificate of indebtedness?
Code of Federal Regulations, 2010 CFR
2010-07-01
... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What regulations cover a certificate of indebtedness? 363.134 Section 363.134 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false [Reserved] 3.134-3.135 Section 3.134-3.135 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false [Reserved] 3.134-3.135 Section 3.134-3.135 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false [Reserved] 3.134-3.135 Section 3.134-3.135 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...
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Code of Federal Regulations, 2014 CFR
2014-01-01
... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false [Reserved] 3.134-3.135 Section 3.134-3.135 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...
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Code of Federal Regulations, 2012 CFR
2012-01-01
... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false [Reserved] 3.134-3.135 Section 3.134-3.135 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...
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Yoshida, Hideo; Ashikawa, Yuka; Itoh, Shinsuke; Nakagawa, Takashi; Asanuma, Akimune; Tanabe, Sohei; Inoue, Yoshihiro; Hidaka, Hiroyoshi
2012-01-01
Background K-134 is a more potent antiplatelet drug with a selective inhibitory effect on phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. Objectives This study was performed to compare the ameliorating effects of K-134 and cilostazol on brain damage in an experimental photothrombotic cerebral infarction model. Methods and Results We investigated the effects of oral preadministration of PDE3 inhibitors in a rat stroke model established by photothrombotic middle cerebral artery (MCA) occlusion. K-134 significantly prolonged MCA occlusion time at doses >10 mg/kg, and reduced cerebral infarct size at 30 mg/kg in the stroke model (n = 12, 87.5±5.6 vs. 126.8±7.5 mm3, P<0.01), indicating its potent antithrombotic effect. On the other hand, the effects of cilostazol on MCA occlusion time and cerebral infarct size are relatively weak even at the high dosage of 300 mg/kg. Furthermore, K-134 blocked rat platelet aggregation more potently than cilostazol in vitro. Also in an arteriovenous shunt thrombosis model, K-134 showed an antithrombotic effect greater than cilostazol. Conclusions These findings suggest that K-134, which has strong antithrombotic activity, is a promising drug for prevention of cerebral infarction associated with platelet hyperaggregability. PMID:23110051
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Yoshida, Hideo; Ashikawa, Yuka; Itoh, Shinsuke; Nakagawa, Takashi; Asanuma, Akimune; Tanabe, Sohei; Inoue, Yoshihiro; Hidaka, Hiroyoshi
2012-01-01
K-134 is a more potent antiplatelet drug with a selective inhibitory effect on phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. This study was performed to compare the ameliorating effects of K-134 and cilostazol on brain damage in an experimental photothrombotic cerebral infarction model. We investigated the effects of oral preadministration of PDE3 inhibitors in a rat stroke model established by photothrombotic middle cerebral artery (MCA) occlusion. K-134 significantly prolonged MCA occlusion time at doses >10 mg/kg, and reduced cerebral infarct size at 30 mg/kg in the stroke model (n = 12, 87.5±5.6 vs. 126.8±7.5 mm(3), P<0.01), indicating its potent antithrombotic effect. On the other hand, the effects of cilostazol on MCA occlusion time and cerebral infarct size are relatively weak even at the high dosage of 300 mg/kg. Furthermore, K-134 blocked rat platelet aggregation more potently than cilostazol in vitro. Also in an arteriovenous shunt thrombosis model, K-134 showed an antithrombotic effect greater than cilostazol. These findings suggest that K-134, which has strong antithrombotic activity, is a promising drug for prevention of cerebral infarction associated with platelet hyperaggregability.
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Hämmerle, Sibylle P; Mindeholm, Linda; Launonen, Aino; Kiese, Beate; Loeffler, Rolf; Harfst, Evita; Azria, Moise; Arnold, Michel; John, Markus R
2012-04-01
Parathyroid hormone (PTH), currently the only marketed anabolic treatment for osteoporosis, is available as the full-length hormone, human PTH1-84, or as the human PTH1-34 fragment (teriparatide). Both must be administered as a daily subcutaneous (sc) injection. A new oral formulation of human PTH1-34 (PTH134) is being developed as a more convenient option for patients. In this single-center, partially-blinded, incomplete cross-over study, the safety, tolerability, and exposure of oral PTH134 (teriparatide combined with 2 different quantities of the absorption enhancer 5-CNAC) were assessed in 32 healthy postmenopausal women. 16 subjects were randomized to receive 4 single doses out of 6 different treatments: placebo, teriparatide 20 μg sc, or 1, 2.5, 5 or 10 mg of oral PTH134 formulated with 200 mg 5-CNAC. Subsequently, another 16 subjects were randomized to receive 4 out of 6 different treatments: placebo, teriparatide 20 μg sc, or 2.5 or 5 mg of oral PTH134 formulated with either 100 or 200 mg 5-CNAC. Doses were given ≥6 days apart. All doses of PTH134 were rapidly absorbed, and showed robust blood concentrations in a dose-dependent manner. Interestingly, PTH1-34 disappeared from blood faster after oral than after sc administration. Specifically, 2.5 and 5 mg PTH134 (containing 200 mg 5-CNAC) demonstrated Cmax and AUC0-last values closest to those of sc teriparatide 20 μg (Forsteo®). Mean+/-SD hPTH134 Cmax values were, respectively, 74+/-59, 138+/-101, 717+/-496, and 1624+/-1579 pg/mL for 1, 2.5, 5, and 10 mg doses of this peptide administered with 200 mg 5-CNAC; while mean+/-SD AUC (0-last) values were, respectively, 30+/-40, 62+/-69, 320+/-269, and 627+/-633 h*pg/mL. The corresponding estimates for teriparatide 20 μg sc were 149+/-35 for Cmax and 236+/-58 for AUC (0-last) Ionized calcium remained within normal limits in all treatment groups except for 3 isolated events. Nine subjects withdrew due to treatment-related AEs. Of those, seven were taking PTH134 2.5 or 5 mg: three withdrew for symptomatic hypotension (two of whom were in the 200 mg 5-CNAC group), three because of delayed vomiting (two from the 200 mg 5-CNAC group), one was proactively withdrawn by the investigator for symptomatic hypercalcemia (receiving 2.5 mg/100 mg 5-CNAC) at slightly supra-normal total calcium but normal ionized serum calcium levels. One subject receiving teriparatide and one receiving placebo withdrew for symptomatic hypotension. No serious AEs were reported. In conclusion, the study demonstrated potential therapeutically relevant PTH1-34 systemic exposure levels after oral administration of PTH1-34 formulated with the absorption enhancer 5-CNAC. Doses of 2.5 and 5 mg of oral PTH134 achieved exposure levels closest to those of teriparatide 20 μg sc, with a comparable incidence of AEs in healthy postmenopausal women. Copyright © 2012 Elsevier Inc. All rights reserved.
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10 CFR 60.134 - Design of seals for shafts and boreholes.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 10 Energy 2 2011-01-01 2011-01-01 false Design of seals for shafts and boreholes. 60.134 Section....134 Design of seals for shafts and boreholes. (a) General design criterion. Seals for shafts and... closure. (b) Selection of materials and placement methods. Materials and placement methods for seals shall...
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View of STS-134 Crew Members working on the Middeck
2011-05-17
S134-E-006520 (17 May 2011) --- Astronauts Andrew Feustel (foreground) and Michael Fincke, both STS-134 mission specialists, work to keep order with the large inventory of supplies and equipment on Endeavour's middeck and airlock on the eve of docking day with the International Space Station. Photo credit: NASA.
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19 CFR 134.54 - Articles released from Customs custody.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Articles released from Customs custody. 134.54...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Found Not Legally Marked § 134.54 Articles... value of the articles not properly marked or redelivered. (b) Failure to petition for relief. A written...
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19 CFR 134.35 - Articles substantially changed by manufacture.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 1 2012-04-01 2012-04-01 false Articles substantially changed by manufacture. 134...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.35 Articles substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the...
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19 CFR 134.54 - Articles released from Customs custody.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles released from Customs custody. 134.54...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Found Not Legally Marked § 134.54 Articles... value of the articles not properly marked or redelivered. (b) Failure to petition for relief. A written...
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19 CFR 134.54 - Articles released from Customs custody.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 1 2012-04-01 2012-04-01 false Articles released from Customs custody. 134.54...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Found Not Legally Marked § 134.54 Articles... value of the articles not properly marked or redelivered. (b) Failure to petition for relief. A written...
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19 CFR 134.13 - Imported articles repacked or manipulated.
Code of Federal Regulations, 2012 CFR
2012-04-01
... 19 Customs Duties 1 2012-04-01 2012-04-01 false Imported articles repacked or manipulated. 134.13...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.13 Imported articles repacked or manipulated. (a) Marking requirement. An article within the provisions of this section shall be...
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19 CFR 134.35 - Articles substantially changed by manufacture.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles substantially changed by manufacture. 134...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.35 Articles substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the...
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19 CFR 134.35 - Articles substantially changed by manufacture.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Articles substantially changed by manufacture. 134...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Exceptions to Marking Requirements § 134.35 Articles substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the...
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19 CFR 134.13 - Imported articles repacked or manipulated.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 19 Customs Duties 1 2011-04-01 2011-04-01 false Imported articles repacked or manipulated. 134.13...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.13 Imported articles repacked or manipulated. (a) Marking requirement. An article within the provisions of this section shall be...
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19 CFR 134.13 - Imported articles repacked or manipulated.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 19 Customs Duties 1 2010-04-01 2010-04-01 false Imported articles repacked or manipulated. 134.13...; DEPARTMENT OF THE TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.13 Imported articles repacked or manipulated. (a) Marking requirement. An article within the provisions of this section shall be...
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13 CFR 134.709 - When will a Judge dismiss an appeal?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When will a Judge dismiss an appeal? 134.709 Section 134.709 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women...
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13 CFR 134.713 - When is the record closed?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When is the record closed? 134.713 Section 134.713 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women-Owned Small...
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13 CFR 134.706 - What are the service and filing requirements?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the service and filing requirements? 134.706 Section 134.706 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women...
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13 CFR 134.714 - When must the Judge issue his or her decision?
Code of Federal Regulations, 2010 CFR
2010-01-01
... Appeals From Women-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When must the Judge issue his or her decision? 134.714 Section 134.714 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION...
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21 CFR 133.134 - Cream cheese with other foods.
Code of Federal Regulations, 2011 CFR
2011-04-01
... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Cream cheese with other foods. 133.134 Section 133...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.134 Cream cheese with other foods. (a) Description. Cream cheese with...
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21 CFR 133.134 - Cream cheese with other foods.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Cream cheese with other foods. 133.134 Section 133...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.134 Cream cheese with other foods. (a) Description. Cream cheese with...
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13 CFR 134.715 - Can a Judge reconsider his decision?
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Can a Judge reconsider his decision? 134.715 Section 134.715 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF....715 Can a Judge reconsider his decision? (a) The Judge may reconsider an appeal decision within 20...
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13 CFR 134.616 - How will I know if I receive an award?
Code of Federal Regulations, 2010 CFR
2010-01-01
..., there will also be findings on whether you have unduly protracted the proceedings or whether other... amount requested and the amount awarded. If you have sought an award against more than one federal agency... award? 134.616 Section 134.616 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF...
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40 CFR 86.134-96 - Running loss test.
Code of Federal Regulations, 2014 CFR
2014-07-01
... running loss test procedure as approved for a specific vehicle. (4) High-altitude testing. For testing... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Running loss test. 86.134-96 Section... Heavy-Duty Vehicles; Test Procedures § 86.134-96 Running loss test. (a) Overview. Gasoline- and methanol...
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42 CFR 422.134 - Reward and incentive programs.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 42 Public Health 3 2014-10-01 2014-10-01 false Reward and incentive programs. 422.134 Section 422.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... monetary cap as determined by CMS of a value that may be expected to impact enrollee behavior but not...
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13 CFR 134.212 - Summary decision.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Summary decision. 134.212 Section... CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.212 Summary decision. (a) Grounds. A party may move for summary decision at any time as to all or any portion of the...
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Regulation of endoplasmic reticulum turnover by selective autophagy.
Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor; Koch, Nicole; Mauthe, Mario; Katona, Istvan; Qualmann, Britta; Weis, Joachim; Reggiori, Fulvio; Kurth, Ingo; Hübner, Christian A; Dikic, Ivan
2015-06-18
The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an important role in this process. However, its underlying regulatory mechanisms remain unexplained. Here we show that members of the FAM134 reticulon protein family are ER-resident receptors that bind to autophagy modifiers LC3 and GABARAP, and facilitate ER degradation by autophagy ('ER-phagy'). Downregulation of FAM134B protein in human cells causes an expansion of the ER, while FAM134B overexpression results in ER fragmentation and lysosomal degradation. Mutant FAM134B proteins that cause sensory neuropathy in humans are unable to act as ER-phagy receptors. Consistently, disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death and leads to degeneration of sensory neurons. Therefore, selective ER-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Hong, A.; Mariwala, R.K.; Kane, M.S.
Experimental evidence is provided for adsorptive shape selectivity in the separation of the azeotrope between HF and 1,1,1,2-tetrafluoroethane (134a) over pyrolyzed poly(furfuryl alcohol)-derived carbogenic molecular sieve (PPFA-CMS). The separation can be accomplished over coconut charcoal or Carbosieve G on the basis of the differences in the extent of equilibrium adsorption of HF and 134a. On these adsorbents 134a is more strongly bound than HF, thus it elutes much more slowly from the bed. The heat of adsorption for 134a in the vicinity of 200 C on Carbosieve G is {approximately}8.8 kcal/mol. In contrast, when the same azeotropic mixture is separatedmore » over PPFA-CMS prepared at 500 C, 134a is not adsorbed. As a result 134a elutes from the bed first, followed by HF. The reversal is brought about by the narrower pore size and pore size distribution of the PPFA-CMS versus that for Carbosieve G. Thus the separation over PPFA-CMS is an example of adsorbate shape selectivity and represents a limiting case of kinetic separation.« less
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Technogenic contaminations of the soil-plant cover in the Primorsky Krai, Russia
NASA Astrophysics Data System (ADS)
Molchanova, Inna; Pozolotina, Vera; Mikhailovskaya, Ludmila; Antonova, Elena; Zhuravlev, Yury; Timofeeva, Yana; Burdukovsky, Maxim
2013-04-01
All economical development of the countries carries out monitoring as with the aim to estimate impact of the industrial enterprises and nuclear-energetic complexes as consequences of the nuclear accidents. The investigation the region of the Far East due to proximity to epicentre of accident on Fukushima-1 NPP is of a great interest. The aim of this work are radioecological investigations and estimate technogenic load on the ecosystems of tightly populated plots of the shore zone of the Vladivostok region. Eight plots were located on the investigated territory. The tree fall, forest litters and soils were sampling from the profile cuts of layer by layer, up to 20 cm. The artificial radionuclides (Sr-90 and Cs-134,137), as heavy metals and microelements (Co, Cu, Zn, Pb and Mn) content in the prepared samples was determined. The stock of Sr-90 fluctuates from 0.3 to 1.3 kBq/m2 and Cs-137 was from 0.4 to 3.0 kBq/m2 in the examined soils. On the whole, the level of the radionuclides content in the soil cover is within the limits of the background that was formed in the belt between 50° and 60° of northern latitude. The presence in investigated samples of Cs-134 indicates to contribution of accidental fallout of Fukushima-1 into contamination of the components of the natural ecosystems. In a year's time after the accident the stock of this isotope in the soils was 0.01-0.20 kBq/m^2. It is by factor of 10-100 lower than the stock of Cs-137. Taking into account that the ratio Cs-134/Cs-137 on the moment of accident was equal to unity (1:1). It can be estimated the quantity of Cs-137 entering into environment during post - accident period. This quantity was an average 0.03-0.30 kBq/m2 (with correction on radionuclides decay). The observation for the state of the soil cover includes the estimate of the level and peculiarities of distribution in the soils of heavy metals and microelements. Their content in the soils is formed from Clarke number and additional industrial gas-aerosol fallout. The analysis of a large volume data permitted to calculate the maximal level of the elements content in a soil under influence only natural factors. It was established, that maximal content of Co, Zn, Mn in these soils exceed of their Clarke's numbers. Minimal elements content was found for a tree fall. As a rule, this content is by factor of 10-100 lower than the Clarke values. Maximal concentration is in the soil layer. At the same time the additional technogenic fall-out produces the double increasing of the content of Cu and Pb in the soil layer. For the rest elements the concentrations increased on 8-32%. Acknowledgements. This work was supported by the grant for integrative research between the Ural and Far Eastern Branches of the Russian Academy of Sciences (12-C-4-1001).
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Hanif, Muhammad; Shoaib, Khurram; Saleem, Muhammad; Hasan Rama, Nasim; Zaib, Sumera; Iqbal, Jamshed
2012-01-01
A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease. The molecular docking studies were performed by docking them into the crystal structure of Jack bean urease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results. PMID:22934191
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Pacquette, Lawrence H; Thompson, Joseph J
2015-01-01
AOAC First Action Method 2011.19: Chromium, Selenium, and Molybdenum in Infant Formula and Adult Nutritional Products, was collaboratively studied. This method uses microwave digestion of samples with nitric acid, hydrogen peroxide, and internal standard followed by simultaneous detection of the elements by an inductively coupled plasma (ICP)/MS instrument equipped with a collision/reaction cell. During this collaborative study, nine laboratories from four different countries, using seven different models of ICP/MS instruments, analyzed blind duplicates of seven infant, pediatric, and adult nutritional formulas. One laboratory's set of data was rejected in its entirety. The method demonstrated acceptable repeatability and reproducibility and met the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) Standard Method Performance Requirements (SMPRs®) for almost all of the matrixes analyzed. The Cr, Mo, and Se SPIFAN requirement for repeatability was ≤5% RSD. The SMPR called for a reproducibility of ≤15% RSD for products with ultratrace element concentrations above the targeted LOQ of 20 μg/kg Cr/Mo and 10 μg/kg Se (as ready-to-feed). During this collaborative study, RSDr ranged from 1.0 to 7.0% and RSDR ranged from 2.5 to 13.4% across all three ultratrace elements.
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First-in-human testing of a wirelessly controlled drug delivery microchip.
Farra, Robert; Sheppard, Norman F; McCabe, Laura; Neer, Robert M; Anderson, James M; Santini, John T; Cima, Michael J; Langer, Robert
2012-02-22
The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1-34) [hPTH(1-34)] was delivered from the device in vivo. hPTH(1-34) is the only approved anabolic osteoporosis treatment, but requires daily injections, making patient compliance an obstacle to effective treatment. Furthermore, a net increase in bone mineral density requires intermittent or pulsatile hPTH(1-34) delivery, a challenge for implantable drug delivery products. The microchip-based devices, containing discrete doses of lyophilized hPTH(1-34), were implanted in eight osteoporotic postmenopausal women for 4 months and wirelessly programmed to release doses from the device once daily for up to 20 days. A computer-based programmer, operating in the Medical Implant Communications Service band, established a bidirectional wireless communication link with the implant to program the dosing schedule and receive implant status confirming proper operation. Each woman subsequently received hPTH(1-34) injections in escalating doses. The pharmacokinetics, safety, tolerability, and bioequivalence of hPTH(1-34) were assessed. Device dosing produced similar pharmacokinetics to multiple injections and had lower coefficients of variation. Bone marker evaluation indicated that daily release from the device increased bone formation. There were no toxic or adverse events due to the device or drug, and patients stated that the implant did not affect quality of life.
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NASA Astrophysics Data System (ADS)
Jones, Spencer
2017-09-01
A number of experiments are focused on trying to observe neutrinoless double beta decay to see if neutrinos are Majorana particles, and thus their own antiparticles. If observed, the results could lead to a more direct measurement of neutrino masses, and to an understanding of why each neutrino flavor has the mass that it does. Lepton conservation would be violated, and data could even shed light on the large discrepancy of matter to antimatter found in the universe today, as it is believed that equal amounts of both were present in the first moments after the Big Bang. We plan to study the 134Xe(3He,n)136Ba reaction to inform the proton pairing structure in 136Ba, which is necessary to validate approximations made in calculating the nuclear matrix elements for the neutrinoless double beta decay rate of 136Xe. In particular, the observation of excited 0+ strength would signal a breakdown of the BCS approximation used in QRPA calculations. Design and construction of apparatus to perform this experiment are currently underway. The design of the 3He gas target will be described. This research is supported by the Office of Nuclear Physics in the US Department of Energy Office of Science.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Gündoğdu, Gülsüm; Aytaç, Sevim Peri; Müller, Melanie
The 3-[1-(6-methoxy-2-naphtyl)ethyl]-6-(2,4-dichlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine, C 23H 18Cl 2N 4OS compound was synthesized, as a member of the family of novel potential anticancer agents. The structure of the title compound was characterized by IR, 1H-NMR, mass spectroscopy, and elemental analysis, previously. In this study, the crystal structure of this compound has been determined from synchrotron X-ray powder diffraction data. The crystal structure was solved by simulated annealing and the final structure was achieved by Rietveld refinement method using soft restrains on all interatomic bond lengths and angles. This compound crystallizes in space groupP21,Z= 2, with the unit-cell parametersa= 15.55645(11) Å,b= 8.61693(6) Å,c= 8.56702(6)more » Å,β= 104.3270(4)°, andV= 1112.68(1) Å 3. In the crystal structure, strong C-H∙∙∙πand weak intermolecular hydrogen-bonding interactions link the molecules into a three-dimensional network. The molecules are in a head-to-head arrangement in the unit cell.« less
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25 CFR 224.134 - How often must the Director conduct a periodic review and evaluation?
Code of Federal Regulations, 2010 CFR
2010-04-01
... 25 Indians 1 2010-04-01 2010-04-01 false How often must the Director conduct a periodic review and evaluation? 224.134 Section 224.134 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...
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25 CFR 224.134 - How often must the Director conduct a periodic review and evaluation?
Code of Federal Regulations, 2011 CFR
2011-04-01
... 25 Indians 1 2011-04-01 2011-04-01 false How often must the Director conduct a periodic review and evaluation? 224.134 Section 224.134 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...
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STS-134 crew during food tasting session in JSC Food Lab.
2010-05-25
JSC2010-E-087708 (25 May 2010) --- NASA astronaut Gregory H. Johnson (foreground), STS-134 pilot; along with astronauts Greg Chamitoff and Michael Fincke, both STS-134 mission specialists, participate in a food tasting session in the Habitability and Environmental Factors Office at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration
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13 CFR 134.704 - What are the effects of the appeal on the procurement at issue?
Code of Federal Regulations, 2010 CFR
2010-01-01
... Appeals From Women-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the effects of the appeal on the procurement at issue? 134.704 Section 134.704 Business Credit and Assistance SMALL BUSINESS...
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13 CFR 134.707 - When does the D/GC transmit the protest file and to whom?
Code of Federal Regulations, 2010 CFR
2010-01-01
... Appeals From Women-Owned Small Business Concern (WOSB) and Economically Disadvantaged WOSB Concern (EDWOSB... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When does the D/GC transmit the protest file and to whom? 134.707 Section 134.707 Business Credit and Assistance SMALL BUSINESS...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-23
... Change To Eliminate EDGX Rule 13.4 August 19, 2013. Pursuant to Section 19(b)(1) of the Securities... the Proposed Rule Change The Exchange proposes to eliminate Rule 13.4, ``Assigning of Registered... Proposed Rule Change 1. Purpose The Exchange proposes to eliminate Rule 13.4, ``Assigning of Registered...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-23
... Change To Eliminate EDGA Rule 13.4 August 19, 2013. Pursuant to Section 19(b)(1) of the Securities... the Proposed Rule Change The Exchange proposes to eliminate Rule 13.4, ``Assigning of Registered... Proposed Rule Change 1. Purpose The Exchange proposes to eliminate Rule 13.4, ``Assigning of Registered...
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40 CFR 180.390 - Tebuthiuron; tolerances for residues.
Code of Federal Regulations, 2011 CFR
2011-07-01
... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N... residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N'-dimethylurea... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N...
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40 CFR 180.390 - Tebuthiuron; tolerances for residues.
Code of Federal Regulations, 2014 CFR
2014-07-01
... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N... residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N'-dimethylurea... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N...
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40 CFR 180.390 - Tebuthiuron; tolerances for residues.
Code of Federal Regulations, 2010 CFR
2010-07-01
... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N... residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N'-dimethylurea... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N...
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40 CFR 180.390 - Tebuthiuron; tolerances for residues.
Code of Federal Regulations, 2013 CFR
2013-07-01
... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N... residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N'-dimethylurea... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N...
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40 CFR 180.390 - Tebuthiuron; tolerances for residues.
Code of Federal Regulations, 2012 CFR
2012-07-01
... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N... residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N'-dimethylurea... combined residues of the herbicide tebuthiuron (N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-N,N...
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Code of Federal Regulations, 2012 CFR
2012-10-01
... illness requires specialized services (PASARR/MI). 483.134 Section 483.134 Public Health CENTERS FOR... illness requires specialized services (PASARR/MI). (a) Purpose. The purpose of this section is to identify... this part, needs a specialized services program for mental illness as defined in § 483.120. (b) Data...
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Code of Federal Regulations, 2014 CFR
2014-10-01
... illness requires specialized services (PASARR/MI). 483.134 Section 483.134 Public Health CENTERS FOR... illness requires specialized services (PASARR/MI). (a) Purpose. The purpose of this section is to identify... this part, needs a specialized services program for mental illness as defined in § 483.120. (b) Data...
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NREL, University of Washington Scientists Elevate Quantum Dot Solar Cell
World Record to 13.4 Percent | NREL | News | NREL NREL, University of Washington Scientists Elevate Quantum Dot Solar Cell World Record to 13.4 Percent News Release: NREL, University of Washington Scientists Elevate Quantum Dot Solar Cell World Record to 13.4 Percent October 27, 2017 Researchers at the
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13 CFR 134.103 - Rules applicable to time periods provided in this part.
Code of Federal Regulations, 2010 CFR
2010-01-01
... Rules applicable to time periods provided in this part. (a) The day from which the time period is... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Rules applicable to time periods provided in this part. 134.103 Section 134.103 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION...
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Hwang, Seung Rim; Seo, Dong-Hyun; Byun, Youngro; Park, Jin Woo
2016-01-01
The N-terminal 34-amino-acid peptide fragment of human parathyroid hormone PTH (1-34), is used clinically to treat osteoporosis; however, it is currently administered by a once-daily subcutaneous injection, resulting in poor patient compliance. We have developed enteric microcapsules containing an ionic nanocomplex between PTH (1-34) and lysine-linked deoxycholic acid (LysDOCA) for the oral delivery of PTH (1-34). We measured the particle size of the PTH/LysDOCA complex and assessed its biological activity by determining the cAMP content in MC3T3-E1 cells. We also assessed its permeability across a Caco-2 cell monolayer and the bioavailability of the intrajejunally administered PTH/LysDOCA complex compared with PTH (1-34) in rats. In addition, the antiosteoporotic activity of the PTH/LysDOCA complex, encapsulated in an enteric carrier by coaxial ultrasonic atomization, was evaluated after it was orally administered to ovariectomized (OVX) rats. The formation of an ionic complex between PTH (1-34) and LysDOCA produced nanoparticles of diameter 33.0±3.36 nm, and the bioactivity of the complex was comparable with that of PTH (1-34). The Caco-2 cell permeability and AUClast value of the PTH/LysDOCA (1:10) nanocomplex increased by 2.87- and 16.3-fold, respectively, compared with PTH (1-34) alone. Furthermore, the OVX rats treated with oral PTH/LysDOCA-loaded enteric microcapsules showed an increase in bone mineral density (159%), bone volume fraction (175%), and trabecular number (174%) compared with those in the OVX control group. Therefore, the PTH/LysDOCA nanocomplex oral delivery system is a promising treatment modality for osteoporosis because it improves osteogenesis and trabecular connectivity. PMID:27621618
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HFC-134a Emissions in China: An Inventory for 1995-2030
NASA Astrophysics Data System (ADS)
Su, Shenshen; Fang, Xuekun; Wu, Jing; Li, Li; Hu, Jianxin; Han, Jiarui
2014-05-01
HFC-134a is the most important substitute of CFC-12 used in the mobile air-conditioner in China since 1995. The bottom-up method was used to estimate HFC-134a emissions in China, from 1995 to 2030, basing on updated automobile industry data and latest emission characters. From 1995, total HFC-134a emission has kept a high growth rate of nearly 60% per year, and reached 16,414.3 Mg (11,959.4-20,834.5 Mg) in 2010, which was equivalent to 23.5 Mt CO2-eq emissions. Furthermore, the emissions in China accounted for nearly half of total emissions of Non-AnnexI countries in 2008. As for provincial emissions in 2010, provinces with emission greater than 1,000 Mg are Guangdong, Shandong, Jiangsu and Beijing. Quantitative relationship between provincial HFC-134a emissions and GRP of the Tertiary Industry was used to estimate HFC-134a emissions at county level, and Hangzhou municipal district held the maximum emission intensity (4,605 Mg/10,000 km2). For HFC-134a, emissions calculated from the observations within 46 cities through Euler box model are in good agreement with the corresponding emissions estimated from the bottom-up method, verifying that the emission inventory at county level adequately describes the emission spatial pattern. For the future emissions of HFC-134a, projected emissions will reach 89,370.4 Mg (65,959.7- 114,068.2 Mg) in 2030 under the Business-as-usual (BAU) Scenario, but under the Alternative Scenario, a emission reduction potential of 88.6% of the projected BAU emissions would be obtained.
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NASA Astrophysics Data System (ADS)
Tárkányi, F.; Hermanne, A.; Ditrói, F.; Takács, S.; Szücs, Z.; Brezovcsik, K.
2018-01-01
In the frame of a systematic study of deuteron induced activation processes on middle mass elements, excitation functions of the natBa(d,x) 135,133,132La, 135m,133m,133mg,131mgBa, 136mg,134mg,132,129Cs reactions were measured up to 50 MeV for the first time. Cross sections were measured with the activation method using a stacked foil irradiation technique followed by HPGe γ-ray spectrometry. A comparison with the results of the nuclear model TALYS code (reported in the TENDL-2015 library) was done. The potential use of the deuteron induced reactions on Ba for applications (131Cs and 131Ba production) is discussed.
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Increase in HFC-134a emissions in response to the success of the Montreal Protocol
NASA Astrophysics Data System (ADS)
Fortems-Cheiney, A.; Saunois, M.; Pison, I.; Chevallier, F.; Bousquet, P.; Cressot, C.; Montzka, S. A.; Fraser, P. J.; Vollmer, M. K.; Simmonds, P. G.; Young, D.; O'Doherty, S.; Weiss, R. F.; Artuso, F.; Barletta, B.; Blake, D. R.; Li, S.; Lunder, C.; Miller, B. R.; Park, S.; Prinn, R.; Saito, T.; Steele, L. P.; Yokouchi, Y.
2015-11-01
The 1,1,1,2-tetrafluoroethane (HFC-134a), an important alternative to CFC-12 in accordance with the Montreal Protocol on Substances that Deplete the Ozone Layer, is a high global warming potential greenhouse gas. Here we evaluate variations in global and regional HFC-134a emissions and emission trends, from 1995 to 2010, at a relatively high spatial and temporal (3.75° in longitude × 2.5° in latitude and 8 day) resolution, using surface HFC-134a measurements. Our results show a progressive increase of global HFC-134a emissions from 19 ± 2 Gg/yr in 1995 to 167 ± 5 Gg/yr in 2010, with both a slowdown in developed countries and a 20%/yr increase in China since 2005. A seasonal cycle is also seen since 2002, which becomes enhanced over time, with larger values during the boreal summer.
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NASA Astrophysics Data System (ADS)
Komatsubara, Takeo; Sunaga, Takasi; Takahasi, Yasuki
R134a was selected as the alternative refrigerant for R12 because of the similar thermodynamic properties with R12. But refrigeration oil for R12 couldn't be used for R134a because of the immiscibility with R134a. To solve this problem we researched miscible oil with R134a and selected polyol ester oil (POE) as refrigeration oil. But we found sludge deposition into capillary tube after life test of refrigerator with POE and detected metal soap, decomposed oil and alkaline ions by analysis of sludge. This results was proof of phenomena like oil degradation, precipitation of process materials and wear of compressor. Therefore we improved stability and lubricity of POE, reevaluated process materials and contaminations in refrigerating circuit. In this paper we discuss newly developed these technologies and evaluation results of it by life test of refrigerator.
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Fezeu, L; Henegar, A; Kesse-Guyot, E; Julia, C; Galan, P; Hercberg, S; Ristow, M; Czernichow, S
2010-10-01
Supplementation with high doses of antioxidant vitamins prevents the insulin-sensitizing effects of physical exercise. However, little is known whether antioxidant supplementation affects the incidence of impaired fasting glucose (IFG). Data from 8938 subjects included in a randomized controlled trial on supplementation with antioxidants vitamins and trace elements at nutritional doses (SU.VI.MAX) were used to examine the effects of antioxidants on incident IFG after 7.5 years of follow-up, with and without stratification for daily physical exercise. The odds-ratio (95% CI) for developing an IFG among study participants receiving antioxidant supplementation was 1.34 (0.90-1.97) (p=0.33), in comparison to placebo. This risk did not vary significantly according to physical activity level (p for homogeneity=0.10). Supplementation with trace elements and antioxidants at nutritional doses apparently does not affect the incidence of IFG irrespective of self-reported physical exercise habits. © Georg Thieme Verlag KG Stuttgart · New York.
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13 CFR 134.703 - When must a person file an appeal from an WOSB or EDWOSB protest determination?
Code of Federal Regulations, 2010 CFR
2010-01-01
... APPEALS Rules of Practice for Appeals From Women-Owned Small Business Concern (WOSB) and Economically... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When must a person file an appeal from an WOSB or EDWOSB protest determination? 134.703 Section 134.703 Business Credit and Assistance...
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Code of Federal Regulations, 2011 CFR
2011-10-01
... Terminal (VSAT) and C-band Small Aperture Terminal (CSAT) networks. 25.134 Section 25.134 Telecommunication...) and C-band Small Aperture Terminal (CSAT) networks. (a)(1) VSAT networks operating in the 12/14 GHz bands. All applications for digital VSAT networks granted on or before September 15, 2005, with a...
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Code of Federal Regulations, 2010 CFR
2010-10-01
... Terminal (VSAT) and C-band Small Aperture Terminal (CSAT) networks. 25.134 Section 25.134 Telecommunication...) and C-band Small Aperture Terminal (CSAT) networks. (a)(1) VSAT networks operating in the 12/14 GHz bands. All applications for digital VSAT networks granted on or before September 15, 2005, with a...
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49 CFR 393.134 - What are the rules for securing roll-on/roll-off or hook lift containers?
Code of Federal Regulations, 2011 CFR
2011-10-01
... or hook lift containers? 393.134 Section 393.134 Transportation Other Regulations Relating to... for securing roll-on/roll-off or hook lift containers? (a) Applicability. The rules in this section apply to the transportation of roll-on/roll-off or hook lift containers. (b) Securement of a roll-on...
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49 CFR 393.134 - What are the rules for securing roll-on/roll-off or hook lift containers?
Code of Federal Regulations, 2010 CFR
2010-10-01
... or hook lift containers? 393.134 Section 393.134 Transportation Other Regulations Relating to... for securing roll-on/roll-off or hook lift containers? (a) Applicability. The rules in this section apply to the transportation of roll-on/roll-off or hook lift containers. (b) Securement of a roll-on...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 3 2010-01-01 2010-01-01 false Forwarding of applications for State grants for technical assistance, program assistance, and marketing. 455.134 Section 455.134 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION GRANT PROGRAMS FOR SCHOOLS AND HOSPITALS AND BUILDINGS OWNED BY UNITS OF LOCAL GOVERNMENT AND PUBLIC CARE INSTITUTIONS State...
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Code of Federal Regulations, 2012 CFR
2012-01-01
... 10 Energy 3 2012-01-01 2012-01-01 false Uniform test methods for the measurement of energy consumption and water consumption of automatic commercial ice makers. 431.134 Section 431.134 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Automatic Commercial Ice Makers Test...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 10 Energy 3 2010-01-01 2010-01-01 false Uniform test methods for the measurement of energy consumption and water consumption of automatic commercial ice makers. 431.134 Section 431.134 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Automatic Commercial Ice Makers Test...
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76 FR 31800 - Airworthiness Directives; Viking Air Limited Model DHC-3 (Otter) Airplanes
Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-02
...: ``Airspeed limitation: VMO = 144 MPH for the effective date of this land/ski plane and VMO = 134 MPH for... limit for land/ in-service (TIS) after the ski plane and 134 MPH, VMO speed limit for seaplane... land/ski the effective date of this plane and/or with a red radial at 134 MPH for a seaplane. This...
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Bęczkowski, Paweł M; Techakriengkrai, Navapon; Logan, Nicola; McMonagle, Elizabeth; Litster, Annette; Willett, Brian J; Hosie, Margaret J
2014-11-28
Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.
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Kumamoto, Yuichiro; Aoyama, Michio; Hamajima, Yasunori; Nishino, Shigeto; Murata, Akihiko; Kikuchi, Takashi
2017-08-01
We measured radiocesium ( 134 Cs and 137 Cs) in seawater from the western subarctic area of the North Pacific Ocean, Bering Sea, and Arctic Ocean in 2013 and 2014. Fukushima-derived 134 Cs in surface seawater was observed in the western subarctic area and Bering Sea but not in the Arctic Ocean. Vertical profile of 134 Cs in the Canada Basin of the Arctic Ocean implies that Fukushima-derived 134 Cs intruded into the basin from the Bering Sea through subsurface (150m depth) in 2014. Copyright © 2017 Elsevier Ltd. All rights reserved.
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134Cs emission probabilities determination by gamma spectrometry
NASA Astrophysics Data System (ADS)
de Almeida, M. C. M.; Poledna, R.; Delgado, J. U.; Silva, R. L.; Araujo, M. T. F.; da Silva, C. J.
2018-03-01
The National Laboratory for Ionizing Radiation Metrology (LNMRI/IRD/CNEN) of Rio de Janeiro performed primary and secondary standardization of different radionuclides reaching satisfactory uncertainties. A solution of 134Cs radionuclide was purchased from commercial supplier to emission probabilities determination of some of its energies. 134Cs is a beta gamma emitter with 754 days of half-life. This radionuclide is used as standard in environmental, water and food control. It is also important to germanium detector calibration. The gamma emission probabilities (Pγ) were determined mainly for some energies of the 134Cs by efficiency curve method and the Pγ absolute uncertainties obtained were below 1% (k=1).
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Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells.
Jang, Hyo Sang; Pearce, Martin; O'Donnell, Edmond F; Nguyen, Bach Duc; Truong, Lisa; Mueller, Monica J; Bisson, William H; Kerkvliet, Nancy I; Tanguay, Robert L; Kolluri, Siva Kumar
2017-12-01
We previously reported that raloxifene, an estrogen receptor modulator, is also a ligand for the aryl hydrocarbon receptor (AhR). Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. We performed structure-activity studies with seven raloxifene analogs to better understand the structural requirements of raloxifene for induction of AhR-mediated transcriptional activity and apoptosis. We identified Y134 as a raloxifene analog that activates AhR-mediated transcriptional activity and induces apoptosis in MDA-MB-231 human triple negative breast cancer cells. Suppression of AhR expression strongly reduced apoptosis induced by Y134, indicating the requirement of AhR for Y134-induced apoptosis. Y134 also induced apoptosis in hepatoma cells without having an effect on cell cycle regulation. Toxicity testing on zebrafish embryos revealed that Y134 has a significantly better safety profile than raloxifene. Our studies also identified an analog of raloxifene that acts as a partial antagonist of the AhR, and is capable of inhibiting AhR agonist-induced transcriptional activity. We conclude that Y134 is a promising raloxifene analog for further optimization as an anti-cancer agent targeting the AhR.