Sample records for element 145

  1. 40 CFR 145.22 - Elements of a program submission.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

  2. 40 CFR 145.22 - Elements of a program submission.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

  3. 40 CFR 145.22 - Elements of a program submission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

  4. 40 CFR 145.22 - Elements of a program submission.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

  5. 40 CFR 145.22 - Elements of a program submission.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

  6. The Superheavy Elements and Anti-Gravity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anastasovski, Petar K.

    2004-02-04

    The essence of any propulsion concept is to overcome gravity. Anti-gravity is a natural means to achieve this. Thus, the technology to pursue anti-gravity, by using superheavy elements, may provide a new propulsion paradigm. The theory of superluminal relativity provides a hypothesis for existence of elements with atomic number up to Z = 145, some of which may possess anti-gravity properties. Analysis results show that curved space-time exists demonstrating both gravitic and anti-gravitic properties not only around nuclei but inside the nuclei as well. Two groups of elements (Z < 64 and 63 < Z <145) exist that demonstrate thesemore » capabilities. The nuclei of the first group of elements have the masses with only the property of gravity. The nuclei of the elements of the second group have the masses with both properties: gravity and anti-gravity in two different ranges of curved space-time around the nuclei.. The hypothetical element with Z = 145 is the unique among all elements whose nucleus has only anti-gravity property. It is proposed that this element be named Hawking, in honour of Stephen W. Hawking.« less

  7. The Superheavy Elements and Anti-Gravity

    NASA Astrophysics Data System (ADS)

    Anastasovski, Petar K.

    2004-02-01

    The essence of any propulsion concept is to overcome gravity. Anti-gravity is a natural means to achieve this. Thus, the technology to pursue anti-gravity, by using superheavy elements, may provide a new propulsion paradigm. The theory of superluminal relativity provides a hypothesis for existence of elements with atomic number up to Z = 145, some of which may possess anti-gravity properties. Analysis results show that curved space-time exists demonstrating both gravitic and anti-gravitic properties not only around nuclei but inside the nuclei as well. Two groups of elements (Z < 64 and 63 < Z <145) exist that demonstrate these capabilities. The nuclei of the first group of elements have the masses with only the property of gravity. The nuclei of the elements of the second group have the masses with both properties: gravity and anti-gravity in two different ranges of curved space-time around the nuclei.. The hypothetical element with Z = 145 is the unique among all elements whose nucleus has only anti-gravity property. It is proposed that this element be named Hawking, in honour of Stephen W. Hawking.

  8. Photoeffect cross sections of some rare-earth elements at 145.4 keV

    NASA Astrophysics Data System (ADS)

    Umesh, T. K.; Ranganathaiah, C.; Sanjeevaiah, B.

    1985-08-01

    Total attenuation cross sections in the elements La, Ce, Pr, Nd, Sm, Gd, Dy, Ho, and Er were derived from the measured total cross sections of their simple oxide compounds, by employing the mixture rule at 145.4-keV photon energy. The compound cross sections have been measured by performing transmission experiments in a good geometry setup. From the derived total cross sections of elements, photoeffect cross sections have been obtained by subtracting the theoretical scattering cross sections. A good agreement is observed between the present data of photoeffect cross sections and Scofield's theoretical data.

  9. 47 CFR 69.119 - Basic service element expedited approval process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Basic service element expedited approval... CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges § 69.119 Basic service element... approval of new basic service elements are those indicated in § 1.45 of the rules, except as specified...

  10. 47 CFR 69.119 - Basic service element expedited approval process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Basic service element expedited approval... CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges § 69.119 Basic service element... approval of new basic service elements are those indicated in § 1.45 of the rules, except as specified...

  11. 47 CFR 69.119 - Basic service element expedited approval process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Basic service element expedited approval... CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges § 69.119 Basic service element... approval of new basic service elements are those indicated in § 1.45 of the rules, except as specified...

  12. 47 CFR 69.119 - Basic service element expedited approval process.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Basic service element expedited approval... CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges § 69.119 Basic service element... approval of new basic service elements are those indicated in § 1.45 of the rules, except as specified...

  13. Genome sequencing and comparative genomics of enterohemorrhagic Escherichia coli O145:H25 and O145:H28 reveal distinct evolutionary paths and marked variations in traits associated with virulence & colonization.

    PubMed

    Lorenz, Sandra C; Gonzalez-Escalona, Narjol; Kotewicz, Michael L; Fischer, Markus; Kase, Julie A

    2017-08-22

    Enterohemorrhagic Escherichia coli (EHEC) O145 are among the top non-O157 serogroups associated with severe human disease worldwide. Two serotypes, O145:H25 and O145:H28 have been isolated from human patients but little information is available regarding the virulence repertoire, origin and evolutionary relatedness of O145:H25. Hence, we sequenced the complete genome of two O145:H25 strains associated with hemolytic uremic syndrome (HUS) and compared the genomes with those of previously sequenced O145:H28 and other EHEC strains. The genomes of the two O145:H25 strains were 5.3 Mbp in size; slightly smaller than those of O145:H28 and other EHEC strains. Both strains contained three nearly identical plasmids and several prophages and integrative elements, many of which differed significantly in size, gene content and organization as compared to those present in O145:H28 and other EHECs. Furthermore, notable variations were observed in several fimbrial gene cluster and intimin types possessed by O145:H25 and O145:H28 indicating potential adaptation to distinct areas of host colonization. Comparative genomics further revealed that O145:H25 are genetically more similar to other non-O157 EHEC strains than to O145:H28. Phylogenetic analysis accompanied by comparative genomics revealed that O145:H25 and O145:H28 evolved from two separate clonal lineages and that horizontal gene transfer and gene loss played a major role in the divergence of these EHEC serotypes. The data provide further evidence that ruminants might be a possible reservoir for O145:H25 but that they might be impaired in their ability to establish a persistent colonization as compared to other EHEC strains.

  14. MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer

    PubMed Central

    Suh, Seong O.; Chen, Yi; Zaman, Mohd Saif; Hirata, Hiroshi; Yamamura, Soichiro; Shahryari, Varahram; Liu, Jan; Tabatabai, Z.Laura; Kakar, Sanjay; Deng, Guoren; Tanaka, Yuichiro; Dahiya, Rajvir

    2011-01-01

    MiR-145 is downregulated in various cancers including prostate cancer. However, the underlying mechanisms of miR-145 downregulation are not fully understood. Here, we reported that miR-145 was silenced through DNA hypermethylation and p53 mutation status in laser capture microdissected (LCM) prostate cancer and matched adjacent normal tissues. In 22 of 27 (81%) prostate tissues, miR-145 was significantly downregulated in the cancer compared with the normal tissues. Further studies on miR-145 downregulation mechanism showed that miR-145 is methylated at the promoter region in both prostate cancer tissues and 50 different types of cancer cell lines. In seven cancer cell lines with miR-145 hypermethylation, 5-aza-2′-deoxycytidine treatment dramatically induced miR-145 expression. Interestingly, we also found a significant correlation between miR-145 expression and the status of p53 gene in both LCM prostate tissues and 47 cancer cell lines. In 29 cell lines with mutant p53, miR-145 levels were downregulated in 28 lines (97%), whereas in 18 cell lines with wild-type p53 (WT p53), miR-145 levels were downregulated in only 6 lines (33%, P < 0.001). Electrophoretic mobility shift assay showed that p53 binds to the p53 response element upstream of miR-145, but the binding was inhibited by hypermethylation. To further confirm that p53 binding to miR-145 could regulate miR-145 expression, we transfected WT p53 and MUT p53 into PC-3 cells and found that miR-145 is upregulated by WT p53 but not with MUTp53. The apoptotic cells are increased after WT p53 transfection. In summary, this is the first report documenting that downregulation of miR-145 is through DNA methylation and p53 mutation pathways in prostate cancer. PMID:21349819

  15. Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status

    PubMed Central

    Chen, Yuan; Sun, Yin; Rao, Qun; Xu, Hua; Li, Lei; Chang, Chawnshang

    2015-01-01

    Mutational inactivation of the VHL tumor suppressor plays key roles in the development of renal cell carcinoma (RCC), and mutated VHL-mediated VEGF induction has become the main target for the current RCC therapy. Here we identified a signal pathway of VEGF induction by androgen receptor (AR)/miRNA-145 as a new target to suppress RCC progression. Mechanism dissection revealed that AR might function through binding to the androgen receptor element (ARE) located on the promoter region of miRNA-145 to suppress p53's ability to induce expression of miRNA-145 that normally suppresses expression of HIF2α/VEGF/MMP9/CCND1. Suppressing AR with AR-shRNA or introducing exogenous miRNA-145 mimic can attenuate RCC progression independent of VHL status. MiR-145 mimic in preclinical RCC orthotopic xenograft mouse model revealed its efficacy in suppression of RCC progression. These results together identified signals by AR-suppressed miRNA-145 as a key player in the RCC progression via regulating HIF2α/VEGF/MMP9/CCND1 expression levels. Blockade of the newly identified signal by AR inhibition or miRNA-145 mimics has promising therapeutic benefit to suppress RCC progression. PMID:26304926

  16. Informed decision-making in elective major vascular surgery: analysis of 145 surgeon-patient consultations.

    PubMed

    Etchells, Edward; Ferrari, Michel; Kiss, Alex; Martyn, Nikki; Zinman, Deborah; Levinson, Wendy

    2011-06-01

    Prior studies show significant gaps in the informed decision-making process, a central goal of surgical care. These studies have been limited by their focus on low-risk decisions, single visits rather than entire consultations, or both. Our objectives were, first, to rate informed decision-making for major elective vascular surgery based on audiotapes of actual physician-patient conversations and, second, to compare ratings of informed decision-making for first visits to ratings for multiple visits by the same patient over time. We prospectively enrolled patients for whom vascular surgical treatment was a potential option at a tertiary care outpatient vascular surgery clinic. We audio-taped all surgeon-patient conversations, including multiple visits when necessary, until a decision was made. Using an existing method, we evaluated the transcripts for elements of decision-making, including basic elements (e.g., an explanation of the clinical condition), intermediate elements (e.g., risks and benefits) and complex elements (e.g., uncertainty around the decision). We analyzed 145 surgeon-patient consultations. Overall, 45% of consultations contained complex elements, whereas 23% did not contain the basic elements of decision-making. For the 67 consultations that involved multiple visits, ratings were significantly higher when evaluating all visits (50% complex elements) compared with evaluating only the first visit (33% complex elements, p < 0.001.) We found that 45% of consultations contained complex elements, which is higher than prior studies with similar methods. Analyzing decision-making over multiple visits yielded different results than analyzing decision-making for single visits.

  17. The Development and Evaluation of Color Display Systems for Airborne Applications. Phase 1. Fundamental Visual, Perceptual, and Display System Considerations

    DTIC Science & Technology

    1985-07-18

    Element Predictions 28 2.1.1.2-9 CIELUV Color Difference Derivation Graphically Described In a Three-Dimensional Rectangular Coordinate System 31...in CIE 1976 Coordinates 141 2.2.2-3 Derivation of CIE (L*, U*, V*) Coordinates 145 2.2.2-4 Three-Dimensional Representation of CIELUV Color...Difference Estimates 145 2.2.2-5 Application of CIELUV for Estimating Color Difference on an Electronic Color Display 146 2.2.2-6 Color Performance Envelopes

  18. The Development and Evaluation of Color Systems for Airborne Applications: Fundamental Visual, Perceptual, and Display Systems Considerations.

    DTIC Science & Technology

    1986-02-01

    Ellipses Derived from Both MacAdam’s Empirically Derived Color Matching Standard Deviation and Stiles’ Line Element Predictions 28 2.1.1.2-9 CIELUV Color...Coordinates 141 2.2.2-3 Derivation of CIE (L*, U*, V*) Coordinates 145 2.2.2-4 Three-Dimensional Representation of CIELUV Colcr Difference Estimates...145 2.2.2-5 Application of CIELUV for Estimating Color Difference on an Electronic Color Display 146 2.2.2-6 Color Performance Envelopes and Optimized

  19. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sandora, McCullen, E-mail: sandora@cp3.dias.sdu.dk

    We use the existence of habitable planets to impose anthropic requirements on the fine structure constant, α. To this effect, we present two considerations that restrict its value to be very near the one observed. The first, that the end product of stellar fusion is iron and not one of its neighboring elements, restricts α{sup -1} to be 145± 50. The second, that radiogenic heat in the Earth's interior remains adequately productive for billions of years, restricts it to be 145±9. A connection with the grand unified theory window is discussed, effectively providing a route to probe ultra-high energy physicsmore » with upcoming advances in planetary science.« less

  20. 40 CFR 145.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (underground injection control—UIC) of SDWA, and includes the elements which must be part of submissions to EPA... requirements of this part, the Safe Drinking Water Act and any comments received. (e) Upon approval of a State... the Administrator to delegate primary enforcement responsibility for the Underground Injection Control...

  1. Hydrolysis of soybean protein improves iron bioavailability

    USDA-ARS?s Scientific Manuscript database

    Iron is an important trace metal element in human body. Iron deficiency affects human health, especially pregnant women and children. Soybean protein is a popular food in Asia and can contain a high amount of iron (145.70±0.74 ug/g); however, it is usually reported as an inhibitor of iron absorption...

  2. ISOLATION OF SMOOTH VESICLES AND FREE RIBOSOMES FROM RAT LIVER MICROSOMES

    PubMed Central

    Chauveau, J.; Moulé, Y.; Rouiller, C.; Schneebeli, J.

    1962-01-01

    Microsomes, isolated from rat liver homogenate in 0.88 M sucrose, have been fractionated by differential centrifugation. The 2nd microsomal fraction, sedimented between 60 minutes at 105,000 g and 3 hours at 145,000 g, consists mainly of smooth vesicles, free ribosomes, and ferritin. By utilizing the differences in density existing between the membranes and the granular elements it has been possible to separate the smooth membranes from the free ribosomes and ferritin. The procedure is to resuspend the 2nd microsomal fraction in a sucrose solution of 1.21 or 1.25 density and centrifuge it at 145,000 g for 20 or 40 hours. A centripetal migration of membranes and a centrifugal sedimentation of granular elements are obtained. Phospholipids, as well as the enzymatic activities DPNH-cytochrome c reductase, glucose-6-phosphatase and esterase are localized in the membranes. The free ribosomes have been purified by washing. A concentration of 200 µg RNA per mg nitrogen has been reached. RNA is also present in the membranes. These results are discussed in relation to current views on microsomal structure and chemistry. PMID:13878497

  3. A method to measure cellular adhesion utilizing a polymer micro-cantilever

    NASA Astrophysics Data System (ADS)

    Gaitas, Angelo; Malhotra, Ricky; Pienta, Kenneth

    2013-09-01

    In the present study we engineered a micro-machined polyimide cantilever with an embedded sensing element to investigate cellular adhesion, in terms of its relative ability to stick to a cross-linker, 3,3'-dithiobis[sulfosuccinimidylpropionate], coated on the cantilever surface. To achieve this objective, we investigated adhesive properties of three human prostate cancer cell lines, namely, a bone metastasis derived human prostate cancer cell line (PC3), a brain metastasis derived human prostate cancer cell line (DU145), and a subclone of PC3 (PC3-EMT14). We found that PC3-EMT14, which displays a mesenchymal phenotype, has the least adhesion compared to PC3 and DU145, which exhibit an epithelial phenotype.

  4. Multigrid Equation Solvers for Large Scale Nonlinear Finite Element Simulations

    DTIC Science & Technology

    1999-01-01

    purpose of the second partitioning phase , on each SMP, is to minimize the communication within the SMP; even if a multi - threaded matrix vector product...8.7 Comparison of model with experimental data for send phase of matrix vector product on ne grid...140 8.4 Matrix vector product phase times : : : : : : : : : : : : : : : : : : : : : : : 145 9.1 Flat and

  5. Revisiting the adsorption of copper-phthalocyanine on Au(111) including van der Waals corrections.

    PubMed

    Lüder, Johann; Eriksson, Olle; Sanyal, Biplab; Brena, Barbara

    2014-03-28

    We have studied the adsorption of copper-phthalocyanine on Au(111) by means of van der Waals corrected density functional theory using the Tkatchenko-Scheffler method. We have compared the element and site resolved adsorption distances to recent experimental normal-incident X-ray standing wave measurements. The measured adsorption distances could be reproduced within a deviation of 1% for the Cu atom, 1% for the C atoms, and 2% for the N atoms. The molecule was found to have a magnetic moment of 1 μB distributed over the Cu and the N atoms of the pyrrole ring. Simulated scanning tunnel microscopy images based on the total and on the spin-resolved differential charge densities are provided for bias voltages of -1.45 and 1.45 eV.

  6. Overseas Absentee Ballot Handling in DOD

    DTIC Science & Technology

    2001-06-22

    Performed . We reviewed pertinent laws, policies, and guidance dated from May 1980 through January 2000 related to the absentee ballot process and the...OVERSEAS ABSENTEE BALLOT HANDLING IN DOD Report No. D-2001-145 June 22, 2001 Office of the Inspector...34) Title and Subtitle Overseas Absentee Ballot Handling in DOD Contract or Grant Number Program Element Number Authors Project Number Task Number

  7. [LincRNA-ROR functions as a ceRNA to regulate Oct4, Sox2, and Nanog expression by sponging miR-145 and its effect on biologic characteristics of colonic cancer stem cells].

    PubMed

    Yan, Z Y; Sun, X C

    2018-04-08

    Objective: To investigate the impact of lincRNA-ROR, a ceRNA by binding miR-145 on the expression of the downstream genes Oct4, Sox2 and Nanog, and related biological characteristics of colon cancer stem cells, and to elucidate the clinical significance of this molecular regulatory network. Methods: Fifty-two cases of colorectal cancer tissue and adjacent tissue were collected at Nanyang City Central Hospital and Nanyang Second Hospital, Henan Province, from 2014 to 2016. Real-time quantitative polymerase chain reaction (qPCR) was used to detect the expression of lincRNA-ROR and miR-145 in colorectal cancer tissue and isolated colon cancer cells. The correlation between the expression of lincRNA-ROR, miR-145 and the clinicopathologic features of colon cancer was performed. CD44(-)CD133(-) and CD44(+) CD133(+) cells were isolated from SW1116 by using flow cytometry. The expression of CD44, CD133, Oct4, Sox2, Nanog, lincRNA-ROR and miR-145 in cells were detected by qPCR. The relationship between lincRNA-ROR, miR-145, Oct4, Sox2 and Nanog was analyzed by bioinformatics, dual luciferase reporter assay, qPCR and Western blot. The effects of silencing lincRNA-ROR on the proliferation and chemosensitivity of colon cancer stem cells were detected by MTT, colony formation. Results: LincRNA-ROR was frequently up-regulated and inversely correlated with miR-145 down-regulation in the colon cancer specimens( P <0.05). LincRNA-ROR was related to tumor size, lymph node involvement and distant metastasis( P <0.05), and miR-145 was found related to tumor size and tumor location( P <0.05). CD44(+) CD133(+) cells were successfully isolated from SW1116 by flow cytometry. The levels of CD44, CD133, Oct4, Sox2, Nanog, lincRNA-ROR in CD44(+) CD133(+) cells were significantly increased, while miR-145 was decreased compared with CD44(-)CD133(-)cells( P <0.05). The levels of CD44, CD133, lnc-ROR in CD44(+) CD133(+) cells were significantly reduced upon cell adherence, while miR-145 was significantly increased( P <0.05). Bioinformatics analysis revealed that lincRNA-ROR shared miRNA response elements with core transcription factors Oct4, Sox2 and Nanog. MiR-145 significantly inhibited the expression of lincRNA-ROR, Oct4, Sox2 and Nanog. Silencing lincRNA-ROR significantly inhibited colon cancer stem cells proliferation and increased the sensitivity to chemotherapy. Conclusions: Linc-ROR functions as a key ceRNA to prevent core TFs, e. g., Oct4, Sox2, Nanog, from miR-145-mediated suppression in colon cancer stem cells and regulates cell proliferation and chemosensitivity.The data may provide insights into the pathophysiological interactions of the components of genetic networks in the development of colon cancer and may lead to new therapies in the future.

  8. Adaptive Control Allocation for Fault Tolerant Overactuated Autonomous Vehicles

    DTIC Science & Technology

    2007-11-01

    Tolerant Overactuated Autonomous Vehicles Casavola, A.; Garone, E. (2007) Adaptive Control Allocation for Fault Tolerant Overactuated Autonomous ...Adaptive Control Allocation for Fault Tolerant Overactuated Autonomous Vehicles 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...Tolerant Overactuated Autonomous Vehicles 3.2 - 2 RTO-MP-AVT-145 UNCLASSIFIED/UNLIMITED Control allocation problem (CAP) - Given a virtual input v(t

  9. Revisiting the adsorption of copper-phthalocyanine on Au(111) including van der Waals corrections

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lüder, Johann; Eriksson, Olle; Sanyal, Biplab

    2014-03-28

    We have studied the adsorption of copper-phthalocyanine on Au(111) by means of van der Waals corrected density functional theory using the Tkatchenko-Scheffler method. We have compared the element and site resolved adsorption distances to recent experimental normal-incident X-ray standing wave measurements. The measured adsorption distances could be reproduced within a deviation of 1% for the Cu atom, 1% for the C atoms, and 2% for the N atoms. The molecule was found to have a magnetic moment of 1 μ{sub B} distributed over the Cu and the N atoms of the pyrrole ring. Simulated scanning tunnel microscopy images based onmore » the total and on the spin-resolved differential charge densities are provided for bias voltages of −1.45 and 1.45 eV.« less

  10. Three-dimensional analysis of chevron-notched specimens by boundary integral method

    NASA Technical Reports Server (NTRS)

    Mendelson, A.; Ghosn, L.

    1983-01-01

    The chevron-notched short bar and short rod specimens was analyzed by the boundary integral equations method. This method makes use of boundary surface elements in obtaining the solution. The boundary integral models were composed of linear triangular and rectangular surface segments. Results were obtained for two specimens with width to thickness ratios of 1.45 and 2.00 and for different crack length to width ratios ranging from 0.4 to 0.7. Crack opening displacement and stress intensity factors determined from displacement calculations along the crack front and compliance calculations were compared with experimental values and with finite element analysis.

  11. Theoretical calculation of pKa reveals an important role of Arg205 in the activity and stability of Streptomyces sp. N174 chitosanase.

    PubMed

    Fukamizo, T; Juffer, A H; Vogel, H J; Honda, Y; Tremblay, H; Boucher, I; Neugebauer, W A; Brzezinski, R

    2000-08-18

    Based on the crystal structure of chitosanase from Streptomyces sp. N174, we have calculated theoretical pK(a) values of the ionizable groups of this protein using a combination of the boundary element method and continuum electrostatics. The pK(a) value obtained for Arg(205), which is located in the catalytic cleft, was abnormally high (>20.0), indicating that the guanidyl group may interact strongly with nearby charges. Chitosanases possessing mutations in this position (R205A, R205H, and R205Y), produced by Streptomyces lividans expression system, were found to have less than 0.3% of the activity of the wild type enzyme and to possess thermal stabilities 4-5 kcal/mol lower than that of the wild type protein. In the crystal structure, the Arg(205) side chain is in close proximity to the Asp(145) side chain (theoretical pK(a), -1.6), which is in turn close to the Arg(190) side chain (theoretical pK(a), 17.7). These theoretical pK(a) values are abnormal, suggesting that both of these residues may participate in the Arg(205) interaction network. Activity and stability experiments using Asp(145)- and Arg(190)-mutated chitosanases (D145A and R190A) provide experimental data supporting the hypothesis derived from the theoretical pK(a) data and prompt the conclusion that Arg(205) forms a strong interaction network with Asp(145) and Arg(190) that stabilizes the catalytic cleft.

  12. Multiple origins for the DLA at zabs = 0.313 toward PKS 1127-145 indicated by a complex dust depletion pattern of Ca, Ti, and Mn

    NASA Astrophysics Data System (ADS)

    Guber, C. R.; Richter, P.; Wendt, M.

    2018-01-01

    Aims: We aim to investigate the dust depletion properties of optically thick gas in and around galaxies and its origin we study in detail the dust depletion patterns of Ti, Mn, and Ca in the multi-component damped Lymanα (DLA) absorber at zabs = 0.313 toward the quasar PKS 1127-145. Methods: We performed a detailed spectral analysis of the absorption profiles of Ca II, Mn II, Ti II, and Na I associated with the DLA toward PKS 1127-145, based on optical high-resolution data obtained with the UVES instrument at the Very Large Telescope. We obtained column densities and Doppler-parameters for the ions listed above and determine their gas-phase abundances, from which we conclude on their dust depletion properties. We compared the Ca and Ti depletion properties of this DLA with that of other DLAs. Results: One of the six analyzed absorption components (component 3) shows a striking underabundance of Ti and Mn in the gas-phase, indicating the effect of dust depletion for these elements and a locally enhanced dust-to-gas ratio. In this DLA and in other similar absorbers, the Mn II abundance follows that of Ti II very closely, implying that both ions are equally sensitive to the dust depletion effects. Conclusions: Our analysis indicates that the DLA toward PKS 1127-145 has multiple origins. With its narrow line width and its strong dust depletion, component 3 points toward the presence of a neutral gas disk from a faint LSB galaxy in front of PKS 1127-145, while the other, more diffuse and dust-poor, absorption components possibly are related to tidal gas features from the interaction between the various, optically confirmed galaxy-group members. In general, the Mn/Ca II ratio in sub-DLAs and DLAs possibly serves as an important indicator to discriminate between dust-rich and dust-poor in neutral gas in and around galaxies.

  13. Levels of eight trace elements in edible mushrooms from a rural area.

    PubMed

    Svoboda, Lubomír; Chrastný, Vladislav

    2008-01-01

    Eight trace elements were determined using ICP-MS in 78 fruiting body samples of 22 edible mushroom species. The mushrooms were collected from four sites in a rural area, unpolluted by human activity. Median values (dry matter) were as follows: Arsenic (As) 1.45 mg kg(-1), barium (Ba) 1.41 mg kg(-1), cobalt (Co) 0.28 mg kg(-1), copper (Cu) 47.0 mg kg(-1), rubidium (Rb) 130 mg kg(-1), silver (Ag) 2.95 mg kg(-1), thallium (Tl) 0.02 mg kg(-1) and vanadium (V) 0.25 mg kg(-1). Higher trace element accumulation was observed in samples of Macrolepiota procera, Macrolepiota rhacodes, Lycoperdon perlatum, Lycoperdon gigantea and Xerocomus chrysenteron for As and Cu, and in samples of Cantharellus cibarius and of genera Boletus and Suillus for Rb.

  14. Cost-effective large-scale fabrication of diffractive optical elements by using conventional semiconducting processes.

    PubMed

    Yoo, Seunghwan; Song, Ho Young; Lee, Junghoon; Jang, Cheol-Yong; Jeong, Hakgeun

    2012-11-20

    In this article, we introduce a simple fabrication method for SiO(2)-based thin diffractive optical elements (DOEs) that uses the conventional processes widely used in the semiconductor industry. Photolithography and an inductively coupled plasma etching technique are easy and cost-effective methods for fabricating subnanometer-scale and thin DOEs with a refractive index of 1.45, based on SiO(2). After fabricating DOEs, we confirmed the shape of the output light emitted from the laser diode light source and applied to a light-emitting diode (LED) module. The results represent a new approach to mass-produce DOEs and realize a high-brightness LED module.

  15. Development of 1.45-mm resolution four-layer DOI-PET detector for simultaneous measurement in 3T MRI.

    PubMed

    Nishikido, Fumihiko; Tachibana, Atsushi; Obata, Takayuki; Inadama, Naoko; Yoshida, Eiji; Suga, Mikio; Murayama, Hideo; Yamaya, Taiga

    2015-01-01

    Recently, various types of PET-MRI systems have been developed by a number of research groups. However, almost all of the PET detectors used in these PET-MRI systems have no depth-of-interaction (DOI) capability. The DOI detector can reduce the parallax error and lead to improvement of the performance. We are developing a new PET-MRI system which consists of four-layer DOI detectors positioned close to the measured object to achieve high spatial resolution and high scanner sensitivity. As a first step, we are investigating influences the PET detector and the MRI system have on each other using a prototype four-layer DOI-PET detector. This prototype detector consists of a lutetium yttrium orthosilicate crystal block and a 4 × 4 multi-pixel photon counter array. The size of each crystal element is 1.45 mm × 1.45 mm × 4.5 mm, and the crystals are arranged in 6 × 6 elements × 4 layers with reflectors. The detector and some electric components are packaged in an aluminum shielding box. Experiments were carried out with 3.0 T MRI (GE, Signa HDx) and a birdcage-type RF coil. We demonstrated that the DOI-PET detector was normally operated in simultaneous measurements with no influence of the MRI measurement. A slight influence of the PET detector on the static magnetic field of the MRI was observed near the PET detector. The signal-to-noise ratio was decreased by presence of the PET detector due to environmental noise entering the MRI room through the cables, even though the PET detector was not powered up. On the other hand, no influence of electric noise from the PET detector in the simultaneous measurement on the MRI images was observed, even though the PET detector was positioned near the RF coil.

  16. Three-dimensional finite-element analysis of chevron-notched fracture specimens

    NASA Technical Reports Server (NTRS)

    Raju, I. S.; Newman, J. C., Jr.

    1984-01-01

    Stress-intensity factors and load-line displacements were calculated for chevron-notched bar and rod fracture specimens using a three-dimensional finite-element analysis. Both specimens were subjected to simulated wedge loading (either uniform applied displacement or uniform applied load). The chevron-notch sides and crack front were assumed to be straight. Crack-length-to-specimen width ratios (a/w) ranged from 0.4 to 0.7. The width-to-thickness ratio (w/B) was 1.45 or 2. The bar specimens had a height-to-width ratio of 0.435 or 0.5. Finite-element models were composed of singularity elements around the crack front and 8-noded isoparametric elements elsewhere. The models had about 11,000 degrees of freedom. Stress-intensity factors were calculated by using a nodal-force method for distribution along the crack front and by using a compliance method for average values. The stress intensity factors and load-line displacements are presented and compared with experimental solutions from the literature. The stress intensity factors and load-line displacements were about 2.5 and 5 percent lower than the reported experimental values, respectively.

  17. Grain Boundary Complexions

    DTIC Science & Technology

    2014-05-01

    for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE MAY 2014 2. REPORT...TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE Grain boundary complexions 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...specific adsorption sites of rare- earth elements at IGF/grain inter- faces [142–144], and the viscosity [145] and mechanical strength [146–148] of

  18. Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer

    PubMed Central

    Daubas, Philippe; Duval, Nathalie; Bajard, Lola; Langa Vives, Francina; Robert, Benoît; Mankoo, Baljinder S.; Buckingham, Margaret

    2015-01-01

    ABSTRACT Skeletal myogenesis in vertebrates is initiated at different sites of skeletal muscle formation during development, by activation of specific control elements of the myogenic regulatory genes. In the mouse embryo, Myf5 is the first myogenic determination gene to be expressed and its spatiotemporal regulation requires multiple enhancer sequences, extending over 120 kb upstream of the Mrf4-Myf5 locus. An enhancer, located at −57/−58 kb from Myf5, is responsible for its activation in myogenic cells derived from the hypaxial domain of the somite, that will form limb muscles. Pax3 and Six1/4 transcription factors are essential activators of this enhancer, acting on a 145-bp core element. Myogenic progenitor cells that will form the future muscle masses of the limbs express the factors necessary for Myf5 activation when they delaminate from the hypaxial dermomyotome and migrate into the forelimb bud, however they do not activate Myf5 and the myogenic programme until they have populated the prospective muscle masses. We show that Msx1 and Meox2 homeodomain-containing transcription factors bind in vitro and in vivo to specific sites in the 145-bp element, and are implicated in fine-tuning activation of Myf5 in the forelimb. Msx1, when bound between Pax and Six sites, prevents the binding of these key activators, thus inhibiting transcription of Myf5 and consequent premature myogenic differentiation. Meox2 is required for Myf5 activation at the onset of myogenesis via direct binding to other homeodomain sites in this sequence. Thus, these homeodomain factors, acting in addition to Pax3 and Six1/4, fine-tune the entry of progenitor cells into myogenesis at early stages of forelimb development. PMID:26538636

  19. 75 FR 8557 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model EMB-135ER...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ..., -145ER, -145LR, -145MP, and - 145MR airplanes: Revise the Airworthiness Limitations (ALS) of the... EMBRAER Model EMB-145EP, -145ER, -145LR, -145MR, and - 145MP airplanes: Revise the ALS of the ICA to... Limitation Requirements, of the MRBR. (3) For all airplanes: Revise the ALS of the ICA to incorporate Tasks...

  20. The Hinge Region as a Key Regulatory Element of Androgen Receptor Dimerization, DNA Binding, and Transactivation

    DTIC Science & Technology

    2005-05-01

    an impaired activity (see report of 2003). We obtained an EGFP fusion from Dr. Karen Knudsen (Ohio University, Cincinatti) in which a Gly-Ala linker ... Smad3 after its acetylation. The mutation of this lysine to glutamine or threonine (mimics acetylation), when expressed in DU145 cells promoted cell...forms. A Gly-Ala linker between the two proteins is necessary, since a direct fusion protein was largely impaired in its activity (not shown). 6. The

  1. A Study of the Time Dependence in Fracture Processes Relating to Service Life Prediction of Adhesive Joints and Advanced Composites.

    DTIC Science & Technology

    1981-04-30

    fluid temperature should exceed 145°F. The flow control module contains all the hydraulic circuit elements necessary for both the pressure line to and...are contained in three basic modules : 1) the hydraulic power supply, 2) a flow control module containing valving, accumulators and filters, and 3) the...hydraulic transient overpressures, is located in the flow control module , as are the high and low pressure filters. The load frame (MTS Systems Corp

  2. Development of a 2,4-Dinitrotoluene-Responsive Synthetic Riboswitch in E. coli cells

    DTIC Science & Technology

    2012-09-01

    INTRODUCTION Riboswitches are naturally-occurring genetic regulatory elements found in the 5′ untranslated region of some mRNA. They provide a method...Industrial Genetics at the University of Stuttgart, Germany, respectively. The plasmid pSAL8.1 was kindly provided by Dr. Justin Gallivan from Emory...vol. 252: Ribozymes and siRNA Protocols, 2nd ed. Humana Press, Inc.; 2004, 145-164. (9) Suess, B., and Weigand, J.E. RNA Biology 2008, 5(1), 1-6

  3. NASTRAN data generation of helicopter fuselages using interactive graphics. [preprocessor system for finite element analysis using IBM computer

    NASA Technical Reports Server (NTRS)

    Sainsbury-Carter, J. B.; Conaway, J. H.

    1973-01-01

    The development and implementation of a preprocessor system for the finite element analysis of helicopter fuselages is described. The system utilizes interactive graphics for the generation, display, and editing of NASTRAN data for fuselage models. It is operated from an IBM 2250 cathode ray tube (CRT) console driven by an IBM 370/145 computer. Real time interaction plus automatic data generation reduces the nominal 6 to 10 week time for manual generation and checking of data to a few days. The interactive graphics system consists of a series of satellite programs operated from a central NASTRAN Systems Monitor. Fuselage structural models including the outer shell and internal structure may be rapidly generated. All numbering systems are automatically assigned. Hard copy plots of the model labeled with GRID or elements ID's are also available. General purpose programs for displaying and editing NASTRAN data are included in the system. Utilization of the NASTRAN interactive graphics system has made possible the multiple finite element analysis of complex helicopter fuselage structures within design schedules.

  4. Elemental Identification by Combining Atomic Force Microscopy and Kelvin Probe Force Microscopy.

    PubMed

    Schulz, Fabian; Ritala, Juha; Krejčí, Ondrej; Seitsonen, Ari Paavo; Foster, Adam S; Liljeroth, Peter

    2018-06-01

    There are currently no experimental techniques that combine atomic-resolution imaging with elemental sensitivity and chemical fingerprinting on single molecules. The advent of using molecular-modified tips in noncontact atomic force microscopy (nc-AFM) has made it possible to image (planar) molecules with atomic resolution. However, the mechanisms responsible for elemental contrast with passivated tips are not fully understood. Here, we investigate elemental contrast by carrying out both nc-AFM and Kelvin probe force microscopy (KPFM) experiments on epitaxial monolayer hexagonal boron nitride (hBN) on Ir(111). The hBN overlayer is inert, and the in-plane bonds connecting nearest-neighbor boron and nitrogen atoms possess strong covalent character and a bond length of only ∼1.45 Å. Nevertheless, constant-height maps of both the frequency shift Δ f and the local contact potential difference exhibit striking sublattice asymmetry. We match the different atomic sites with the observed contrast by comparison with nc-AFM image simulations based on the density functional theory optimized hBN/Ir(111) geometry, which yields detailed information on the origin of the atomic-scale contrast.

  5. A Single Base Difference between Pit-1 Binding Sites at the hGH Promoter and Locus Control Region Specifies Distinct Pit-1 Conformations and Functions

    PubMed Central

    Shewchuk, Brian M.; Ho, Yugong; Liebhaber, Stephen A.; Cooke, Nancy E.

    2006-01-01

    Activation of the human growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus control region (LCR). This LCR is composed of DNase I-hypersensitive sites (HS) located −14.5 kb to −32 kb relative to the hGH-N promoter. HSI, at −14.5 kb, is the dominant determinant of hGH-N expression and is essential for establishment of a 32-kb domain of histone acetylation that encompasses the active hGH locus. This activity is conferred by three binding sites for the POU domain transcription factor Pit-1. These Pit-1 elements are sufficient to activate hGH-N expression in the mouse pituitary. In contrast, Pit-1 sites at the hGH-N promoter are consistently unable to mediate similar activity. In the present study, we demonstrate that the functional difference between the promoter-proximal and the HSI Pit-1 binding sites can be attributed in part to a single base difference. This base affects the conformation of the Pit-1/DNA complex, and reciprocal exchange of the divergent bases between the two sets of Pit-1 elements results in a partial reversal of their transgenic activities. These data support a model in which the Pit-1 binding sites in the hGH LCR allosterically program the bound Pit-1 complex for chromatin activating functions. PMID:16914737

  6. Accuracy of outpatient service data for activity-based funding in New South Wales, Australia.

    PubMed

    Munyisia, Esther N; Reid, David; Yu, Ping

    2017-05-01

    Despite increasing research on activity-based funding (ABF), there is no empirical evidence on the accuracy of outpatient service data for payment. This study aimed to identify data entry errors affecting ABF in two drug and alcohol outpatient clinic services in Australia. An audit was carried out on healthcare workers' (doctors, nurses, psychologists, social workers, counsellors, and aboriginal health education officers) data entry errors in an outpatient electronic documentation system. Of the 6919 data entries in the electronic documentation system, 7.5% (518) had errors, 68.7% of the errors were related to a wrong primary activity, 14.5% were due to a wrong activity category, 14.5% were as a result of a wrong combination of primary activity and modality of care, 1.9% were due to inaccurate information on a client's presence during service delivery and 0.4% were related to a wrong modality of care. Data entry errors may affect the amount of funding received by a healthcare organisation, which in turn may affect the quality of treatment provided to clients due to the possibility of underfunding the organisation. To reduce errors or achieve an error-free environment, there is a need to improve the naming convention of data elements, their descriptions and alignment with the national standard classification of outpatient services. It is also important to support healthcare workers in their data entry by embedding safeguards in the electronic documentation system such as flags for inaccurate data elements.

  7. VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection.

    PubMed

    Fujii, Ken; Sudaka, Yui; Takashino, Ayako; Kobayashi, Kyousuke; Kataoka, Chikako; Suzuki, Tadaki; Iwata-Yoshikawa, Naoko; Kotani, Osamu; Ami, Yasushi; Shimizu, Hiroyuki; Nagata, Noriyo; Mizuta, Katsumi; Matsuzaki, Yoko; Koike, Satoshi

    2018-05-30

    Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and sometimes causes severe or fatal neurological complications. The amino acid at VP1-145 determines virological characteristics of EV71. Viruses with glutamic acid (E) at VP1-145 (VP1-145E) are virulent in neonatal mice and transgenic mice expressing human scavenger receptor B2, whereas those with glutamine (Q) or glycine (G) are not. However, the contribution of this variation to pathogenesis in humans is not fully understood. We compared the virulence of VP1-145E and VP1-145G viruses of Isehara and C7/Osaka backgrounds in cynomolgus monkeys. VP1-145E, but not VP1-145G, viruses induced neurological symptoms. VP1-145E viruses were frequently detected in the tissues of infected monkeys. VP1-145G viruses were detected less frequently and disappeared quickly. Instead, mutants that had a G to E mutation at VP1-145 emerged, suggesting that VP1-145E viruses have a replication advantage in the monkeys. This is consistent with our hypothesis proposed in the accompanying paper that the VP1-145G virus is attenuated due to its adsorption by heparan sulfate. Monkeys infected with both viruses produced neutralizing antibodies before the onset of the disease. Interestingly, VP1-145E viruses were more resistant to neutralizing antibodies than VP1-145G viruses in vitro A small amount of neutralizing antibody raised in the early phase of infection may not be sufficient to block the dissemination of VP1-145E viruses. The different resistance of the VP1-145 variants to neutralizing antibodies may be one of the reasons for the difference in virulence. IMPORTANCE The contribution of VP1-145 variants in humans is not fully understood. In some reports, VP1-145G/Q viruses were more frequently isolated from severely affected than from mildly affected patients, suggesting that VP1-145G/Q viruses are more virulent. In the accompanying paper, we showed that VP1-145E viruses are more virulent than VP1-145G viruses in human SCARB2 transgenic mice. Heparan sulfate acts as a decoy to specifically trap the VP1-145G viruses and leads to abortive infection. Here, we demonstrated that VP1-145G was attenuated in cynomolgus monkeys, suggesting that this hypothesis is also true in a non-human primate model. VP1-145E viruses, but not VP1-145G viruses, were highly resistant to neutralizing antibodies. We propose the difference in resistance against neutralizing antibodies as another mechanism of EV71 virulence. In summary, VP1-145 contributes to virulence determination by controlling attachment receptor usage and antibody sensitivity. Copyright © 2018 American Society for Microbiology.

  8. MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling

    PubMed Central

    Li, Ya-Wen; Chiang, Keng-Yu; Li, Yen-Hsing; Wu, Sung-Yu; Liu, Wangta; Lin, Chia-Ray

    2017-01-01

    MicroRNAs (miRs) are mRNA-regulatory molecules that fine-tune gene expression and modulate both processes of development and tumorigenesis. Our previous studies identified progranulin A (GrnA) as a growth factor which induces zebrafish hepatic outgrowth through MET signaling. We also found that miR-145 is one of potential fine-tuning regulators of GrnA involved in embryonic hepatic outgrowth. The low level of miR-145 seen in hepatocarinogenesis has been shown to promote pathological liver growth. However, little is known about the regulatory mechanism of miR-145 in embryonic liver development. In this study, we demonstrate a significant decrease in miR-145 expression during hepatogenesis. We modulate miR-145 expression in zebrafish embryos by injection with a miR-145 mimic or a miR-145 hairpin inhibitor. Altered embryonic liver outgrowth is observed in response to miR-145 expression modulation. We also confirm a critical role of miR-145 in hepatic outgrowth by using whole-mount in situ hybridization. Loss of miR-145 expression in embryos results in hepatic cell proliferation, and vice versa. Furthermore, we demonstrate that GrnA is a target of miR-145 and GrnA-induced MET signaling is also regulated by miR-145 as determined by luciferase reporter assay and gene expression analysis, respectively. In addition, co-injection of GrnA mRNA with miR-145 mimic or MO-GrnA with miR-145 inhibitor restores the liver defects caused by dysregulation of miR-145 expression. In conclusion, our findings suggest an important role of miR-145 in regulating GrnA-dependent hepatic outgrowth in zebrafish embryonic development. PMID:28531199

  9. Contact mechanics of reverse total shoulder arthroplasty during abduction: the effect of neck-shaft angle, humeral cup depth, and glenosphere diameter.

    PubMed

    Langohr, G Daniel G; Willing, Ryan; Medley, John B; Athwal, George S; Johnson, James A

    2016-04-01

    Implant design parameters can be changed during reverse shoulder arthroplasty (RSA) to improve range of motion and stability; however, little is known regarding their impact on articular contact mechanics. The purpose of this finite element study was to investigate RSA contact mechanics during abduction for different neck-shaft angles, glenosphere sizes, and polyethylene cup depths. Finite element RSA models with varying neck-shaft angles (155°, 145°, 135°), sizes (38 mm, 42 mm), and cup depths (deep, normal, shallow) were loaded with 400 N at physiological abduction angles. The contact area and maximum contact stress were computed. The contact patch and the location of maximum contact stress were typically located inferomedially in the polyethylene cup. On average for all abduction angles investigated, reducing the neck-shaft angle reduced the contact area by 29% for 155° to 145° and by 59% for 155° to 135° and increased maximum contact stress by 71% for 155° to 145° and by 286% for 155° to 135°. Increasing the glenosphere size increased the contact area by 12% but only decreased maximum contact stress by 2%. Decreasing the cup depth reduced the contact area by 40% and increased maximum contact stress by 81%, whereas increasing the depth produced the opposite effect (+52% and -36%, respectively). The location of the contact patch and maximum contact stress in this study matches the area of damage seen frequently on clinical retrievals. This finding suggests that damage to the inferior cup due to notching may be potentiated by contact stresses. Increasing the glenosphere diameter improved the joint contact area and did not affect maximum contact stress. However, although reducing the neck-shaft angle and cup depth can improve range of motion, our study shows that this also has some negative effects on RSA contact mechanics, particularly when combined. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  10. 46 CFR 28.145 - Distress signals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Distress signals. 28.145 Section 28.145 Shipping COAST... VESSELS Requirements for All Vessels § 28.145 Distress signals. Except as provided by 28.305, each vessel must be equipped with the distress signals specified in table 28.145. Table 28.145—Distress Signals...

  11. 19 CFR 145.59 - Seizures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Seizures. 145.59 Section 145.59 Customs Duties U.S...) MAIL IMPORTATIONS Restricted and Prohibited Merchandise § 145.59 Seizures. (a) Articles prohibited and... handled by the Postal Service as specified in §§ 145.51 and 145.52. (b) Notification of seizure or...

  12. 46 CFR 28.145 - Distress signals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Distress signals. 28.145 Section 28.145 Shipping COAST... VESSELS Requirements for All Vessels § 28.145 Distress signals. Except as provided by 28.305, each vessel must be equipped with the distress signals specified in table 28.145. Table 28.145—Distress Signals...

  13. 46 CFR 28.145 - Distress signals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Distress signals. 28.145 Section 28.145 Shipping COAST... VESSELS Requirements for All Vessels § 28.145 Distress signals. Except as provided by 28.305, each vessel must be equipped with the distress signals specified in table 28.145. Table 28.145—Distress Signals...

  14. 46 CFR 28.145 - Distress signals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Distress signals. 28.145 Section 28.145 Shipping COAST... VESSELS Requirements for All Vessels § 28.145 Distress signals. Except as provided by 28.305, each vessel must be equipped with the distress signals specified in table 28.145. Table 28.145—Distress Signals...

  15. Sequence Variations in the Flagellar Antigen Genes fliCH25 and fliCH28 of Escherichia coli and Their Use in Identification and Characterization of Enterohemorrhagic E. coli (EHEC) O145:H25 and O145:H28.

    PubMed

    Beutin, Lothar; Delannoy, Sabine; Fach, Patrick

    2015-01-01

    Enterohemorrhagic E. coli (EHEC) serogroup O145 is regarded as one of the major EHEC serogroups involved in severe infections in humans. EHEC O145 encompasses motile and non-motile strains of serotypes O145:H25 and O145:H28. Sequencing the fliC-genes associated with the flagellar antigens H25 and H28 revealed the genetic diversity of the fliCH25 and fliCH28 gene sequences in E. coli. Based on allele discrimination of these fliC-genes real-time PCR tests were designed for identification of EHEC O145:H25 and O145:H28. The fliCH25 genes present in O145:H25 were found to be very similar to those present in E. coli serogroups O2, O100, O165, O172 and O177 pointing to their common evolution but were different from fliCH25 genes of a multiple number of other E. coli serotypes. In a similar way, EHEC O145:H28 harbor a characteristic fliCH28 allele which, apart from EHEC O145:H28, was only found in enteropathogenic (EPEC) O28:H28 strains that shared some common traits with EHEC O145:H28. The real time PCR-assays targeting these fliCH25[O145] and fliCH28[O145] alleles allow better characterization of EHEC O145:H25 and EHEC O145:H28. Evaluation of these PCR assays in spiked ready-to eat salad samples resulted in specific detection of both types of EHEC O145 strains even when low spiking levels of 1-10 cfu/g were used. Furthermore these PCR assays allowed identification of non-motile E. coli strains which are serologically not typable for their H-antigens. The combined use of O-antigen genotyping (O145wzy) and detection of the respective fliCH25[O145] and fliCH28[O145] allele types contributes to improve identification and molecular serotyping of E. coli O145 isolates.

  16. Sequence Variations in the Flagellar Antigen Genes fliC H25 and fliC H28 of Escherichia coli and Their Use in Identification and Characterization of Enterohemorrhagic E. coli (EHEC) O145:H25 and O145:H28

    PubMed Central

    Beutin, Lothar; Delannoy, Sabine; Fach, Patrick

    2015-01-01

    Enterohemorrhagic E. coli (EHEC) serogroup O145 is regarded as one of the major EHEC serogroups involved in severe infections in humans. EHEC O145 encompasses motile and non-motile strains of serotypes O145:H25 and O145:H28. Sequencing the fliC-genes associated with the flagellar antigens H25 and H28 revealed the genetic diversity of the fliC H25 and fliC H28 gene sequences in E. coli. Based on allele discrimination of these fliC-genes real-time PCR tests were designed for identification of EHEC O145:H25 and O145:H28. The fliC H25 genes present in O145:H25 were found to be very similar to those present in E. coli serogroups O2, O100, O165, O172 and O177 pointing to their common evolution but were different from fliC H25 genes of a multiple number of other E. coli serotypes. In a similar way, EHEC O145:H28 harbor a characteristic fliC H28 allele which, apart from EHEC O145:H28, was only found in enteropathogenic (EPEC) O28:H28 strains that shared some common traits with EHEC O145:H28. The real time PCR-assays targeting these fliC H25[O145] and fliC H28[O145] alleles allow better characterization of EHEC O145:H25 and EHEC O145:H28. Evaluation of these PCR assays in spiked ready-to eat salad samples resulted in specific detection of both types of EHEC O145 strains even when low spiking levels of 1–10 cfu/g were used. Furthermore these PCR assays allowed identification of non-motile E. coli strains which are serologically not typable for their H-antigens. The combined use of O-antigen genotyping (O145wzy) and detection of the respective fliC H25[O145] and fliC H28[O145] allele types contributes to improve identification and molecular serotyping of E. coli O145 isolates. PMID:26000885

  17. Impact Testing of Explosives and Propellants

    DTIC Science & Technology

    1992-06-01

    in order to better understand the test results. The physical behavior of tile drop weight impact test can be modeled on a computer with all of the...SPRING ELEMENTS OF SIMPLIFIED IMPACT MACHINE A-4 NSV’CDDITR-92/280 4 j DISTRIBUTION Copies C~e ATTN ONR 1132P (R MILLER ) 1 ATTN 6-A-145 1 ONT2OT(L V...LIBRARY OF CONGRESS (J W FORBES) 1 WASHINGTON DC 20540 (R11 GUIRGUIS ) 1 (P K GUSTAVSON) I INTERNAL DISTRIBUTION (R N HAY) ! E231 2 (It D JONES) 1 E232 3 (K

  18. The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy

    PubMed Central

    Steffani, Liliana; Martínez, Sebastián; Monterde, Mercedes; Ferri, Blanca; Núñez, Maria Jose; AinhoaRomero-Espinós; Zamora, Omar; Gurrea, Marta; Sangiao-Alvarellos, Susana; Vega, Olivia; Simón, Carlos; Pellicer, Antonio; Tena-Sempere, Manuel

    2014-01-01

    Our objective was to determine the expression of the elements of the Lin28/Let-7 system, and related microRNAs (miRNAs), in early stages of human placentation and ectopic pregnancy, as a means to assess the potential role of this molecular hub in the pathogenesis of ectopic gestation. Seventeen patients suffering from tubal ectopic pregnancy (cases) and forty-three women with normal on-going gestation that desired voluntary termination of pregnancy (VTOP; controls) were recruited for the study. Embryonic tissues were subjected to RNA extraction and quantitative PCR analyses for LIN28B, Let-7a, miR-132, miR-145 and mir-323-3p were performed. Our results demonstrate that the expression of LIN28B mRNA was barely detectable in embryonic tissue from early stages of gestation and sharply increased thereafter to plateau between gestational weeks 7–9. In contrast, expression levels of Let-7, mir-132 and mir-145 were high in embryonic tissue from early gestations (≤6-weeks) and abruptly declined thereafter, especially for Let-7. Opposite trends were detected for mir-323-3p. Embryonic expression of LIN28B mRNA was higher in early stages (≤6-weeks) of ectopic pregnancy than in normal gestation. In contrast, Let-7a expression was significantly lower in early ectopic pregnancies, while miR-132 and miR-145 levels were not altered. Expression of mir-323-3p was also suppressed in ectopic embryonic tissue. We are the first to document reciprocal changes in the expression profiles of the gene encoding the RNA-binding protein, LIN28B, and the related miRNAs, Let-7a, mir-132 and mir-145, in early stages of human placentation. This finding suggests the potential involvement of LIN28B/Let-7 (de)regulated pathways in the pathophysiology of ectopic pregnancy in humans. PMID:24498170

  19. 22 CFR 145.10 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose. 145.10 Section 145.10 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 145.10 Purpose. Sections 145.11...

  20. Personality and music preferences: the influence of personality traits on preferences regarding musical elements.

    PubMed

    Kopacz, Malgorzata

    2005-01-01

    The purpose of this scientific study was to determine how personality traits, as classified by Cattell, influence preferences regarding musical elements. The subject group consisted of 145 students, male and female, chosen at random from different Polish universities. For the purpose of determining their personality traits the participants completed the 16PF Questionnaire (Cattell, Saunders, & Stice, 1957; Russel & Karol, 1993), in its Polish adaptation by Choynowski (Nowakowska, 1970). The participants' musical preferences were determined by their completing a Questionnaire of Musical Preferences (specifically created for the purposes of this research), in which respondents indicated their favorite piece of music. Next, on the basis of the Questionnaire of Musical Preferences, a list of the works of music chosen by the participants was compiled. All pieces were collected on CDs and analyzed to separate out their basic musical elements. The statistical analysis shows that some personality traits: Liveliness (Factor F), Social Boldness (Factor H), Vigilance (Factor L), Openness to Change (Factor Q1), Extraversion (a general factor) have an influence on preferences regarding musical elements. Important in the subjects' musical preferences were found to be those musical elements having stimulative value and the ability to regulate the need for stimulation. These are: tempo, rhythm in relation to metrical basis, number of melodic themes, sound voluminosity, and meter.

  1. 17 CFR 145.0 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Definitions. 145.0 Section 145... INFORMATION § 145.0 Definitions. For the purposes of part 145 the following definitions are applicable..., microfiche, drawing, or computer-stored information or output in the possession of the Commission. The term...

  2. 17 CFR 145.0 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Definitions. 145.0 Section 145... INFORMATION § 145.0 Definitions. For the purposes of part 145 the following definitions are applicable..., microfiche, drawing, or computer-stored information or output in the possession of the Commission. The term...

  3. 17 CFR 145.0 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Definitions. 145.0 Section 145... INFORMATION § 145.0 Definitions. For the purposes of part 145 the following definitions are applicable..., microfiche, drawing, or computer-stored information or output in the possession of the Commission. The term...

  4. 22 CFR 145.70 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose. 145.70 Section 145.70 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS After-the-Award Requirements § 145.70 Purpose. Sections 145.71...

  5. 17 CFR 145.0 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Definitions. 145.0 Section 145... RECORDS AND INFORMATION § 145.0 Definitions. For the purposes of part 145 the following definitions are..., microfiche, drawing, or computer-stored information or output in the possession of the Commission. The term...

  6. Genomic deletion of a long-range bone enhancer misregulatessclerostin in Van Buchem disease

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Loots, Gabriela G.; Kneissel, Michaela; Keller, Hansjoerg

    2005-04-15

    Mutations in distant regulatory elements can negatively impact human development and health, yet due to the difficulty of detecting these critical sequences we predominantly focus on coding sequences for diagnostic purposes. We have undertaken a comparative sequence-based approach to characterize a large noncoding region deleted in patients affected by Van Buchem disease (VB), a severe sclerosing bone dysplasia. Using BAC recombination and transgenesis we characterized the expression of human sclerostin (sost) from normal (hSOSTwt) or Van Buchem(hSOSTvb D) alleles. Only the hSOSTwt allele faithfully expressed high levels of human sost in the adult bone and impacted bone metabolism, consistent withmore » the model that the VB noncoding deletion removes a sost specific regulatory element. By exploiting cross-species sequence comparisons with in vitro and in vivo enhancer assays we were able to identify a candidate enhancer element that drives human sost expression in osteoblast-like cell lines in vitro and in the skeletal anlage of the E14.5 mouse embryo, and discovered a novel function for sclerostin during limb development. Our approach represents a framework for characterizing distant regulatory elements associated with abnormal human phenotypes.« less

  7. 50 CFR 665.145 - At-sea observer coverage.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

  8. 50 CFR 665.145 - At-sea observer coverage.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

  9. 50 CFR 665.145 - At-sea observer coverage.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

  10. 50 CFR 665.145 - At-sea observer coverage.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

  11. 50 CFR 665.145 - At-sea observer coverage.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false At-sea observer coverage. 665.145 Section 665.145 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 665.145 At-sea observer coverage. All fishing vessels subject to §§ 665.140 through 665.145 and...

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke

    Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as inmore » serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.« less

  13. 7 CFR 65.145 - Ginseng.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Ginseng. 65.145 Section 65.145 Agriculture Regulations..., AND GINSENG General Provisions Definitions § 65.145 Ginseng. Ginseng means ginseng root of the genus Panax. ...

  14. 7 CFR 65.145 - Ginseng.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Ginseng. 65.145 Section 65.145 Agriculture Regulations..., AND GINSENG General Provisions Definitions § 65.145 Ginseng. Ginseng means ginseng root of the genus Panax. ...

  15. 7 CFR 65.145 - Ginseng.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Ginseng. 65.145 Section 65.145 Agriculture Regulations..., AND GINSENG General Provisions Definitions § 65.145 Ginseng. Ginseng means ginseng root of the genus Panax. ...

  16. Ku-band field-effect power transistors

    NASA Technical Reports Server (NTRS)

    Taylor, G. C.; Huang, H. C.

    1979-01-01

    A single stage amplifier was developed using an 8 gate, 1200 micrometer width device to give a gain of 3.3 + or - 0.1 dB over the 14.4 to 15.4 GHz band with an output power of 0.48 W and 15% minimum efficiency with 0.255 W of input power. With two 8 gate devices combined and matched on the device carrier, using a lumped element format, a gain of 3 dB was attained over the 14.5 to 15.5 GHz band with a maximum efficiency of 9.9% for an output power of 0.8 W.

  17. Comments on "Drill-string horizontal dynamics with uncertainty on the frictional force" by T.G. Ritto, M.R. Escalante, Rubens Sampaio, M.B. Rosales [J. Sound Vib. 332 (2013) 145-153

    NASA Astrophysics Data System (ADS)

    Li, Zifeng

    2016-12-01

    This paper analyzes the mechanical and mathematical models in "Ritto et al. (2013) [1]". The results are that: (1) the mechanical model is obviously incorrect; (2) the mathematical model is not complete; (3) the differential equation is obviously incorrect; (4) the finite element equation is obviously not discretized from the corresponding mathematical model above, and is obviously incorrect. A mathematical model of dynamics should include the differential equations, the boundary conditions and the initial conditions.

  18. Medical Surveillance Monthly Report (MSMR). Volume 16, Number 4, April 2009

    DTIC Science & Technology

    2009-04-01

    April 2009 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR (S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER...Hepatitis A (μ: 10) Hantavirus disease (μ: 3) Brucellosis (μ: 2) E. coli O157:H7 (μ: 3) West Nile virus (μ: 6) Dengue fever (μ: 4) Ehrlichiosis (μ...uenzae, invasive 0 0 2 2 14 Hantavirus disease 0 6 2 0 0 Heat exhaustion 542 727 566 547 452 Heat stroke 196 163 128 133 145 Hemorrhagic fever 0 0 0

  19. MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.

    PubMed

    Sala, Federica; Aranda, Juan F; Rotllan, Noemi; Ramírez, Cristina M; Aryal, Binod; Elia, Leonardo; Condorelli, Gianluigi; Catapano, Alberico Luigi; Fernández-Hernando, Carlos; Norata, Giuseppe Danilo

    2014-10-01

    The miR-143/145 cluster regulates VSMC specific gene expression, thus controlling differentiation, plasticity and contractile function, and promoting the VSMC phenotypic switch from a contractile/non-proliferative to a migrating/proliferative state. More recently increased miR-145 expression was observed in human carotid atherosclerotic plaques from symptomatic patients. The goal of this study was to investigate the contribution of miR-143/145 during atherogenesis by generating mice lacking miR-143/145 on an Ldlr-deficient background. Ldlr-/- and Ldlr-/--miR-143/145-/- (DKO) were fed a Western diet (WD) for 16 weeks. At the end of the treatment, the lipid profile and the atherosclerotic lesions were assessed in both groups of mice. Absence of miR-143/145 significantly reduced atherosclerotic plaque size and macrophage infiltration. Plasma total cholesterol levels were lower in DKO and FLPC analysis showed decreased cholesterol content in VLDL and LDL fractions. Interestingly miR-143/145 deficiency per se resulted in increased hepatic and vascular ABCA1 expression. We further confirmed the direct regulation of miR-145 on ABCA1 expression by qRT-PCR, Western blotting and 3'UTR-luciferase reporter assays. In summary, miR-143/145 deficiency significantly reduces atherosclerosis in mice. Therapeutic inhibition of miR-145 might be useful for treating atherosclerotic vascular disease.

  20. 9 CFR 145.24 - Terminology and classification; States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... 145.24 Section 145.24 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Multiplier Egg-Type Chicken Breeding Flocks and Products § 145.24 Terminology and...

  1. 9 CFR 145.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Administration. 145.2 Section 145.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.2...

  2. 9 CFR 145.44 - Terminology and classification; States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 145.44 Section 145.44 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Turkey Breeding Flocks and Products § 145.44 Terminology and classification; States...

  3. 9 CFR 145.12 - Inspections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Inspections. 145.12 Section 145.12 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.12...

  4. 9 CFR 145.11 - Supervision.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Supervision. 145.11 Section 145.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.11...

  5. 9 CFR 145.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Administration. 145.2 Section 145.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.2...

  6. 9 CFR 145.7 - Specific provisions for participating dealers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... dealers. 145.7 Section 145.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.7 Specific provisions for participating dealers. Dealers in poultry breeding...

  7. 9 CFR 145.24 - Terminology and classification; States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 145.24 Section 145.24 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Multiplier Egg-Type Chicken Breeding Flocks and Products § 145.24 Terminology and...

  8. 9 CFR 145.34 - Terminology and classification; States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... 145.34 Section 145.34 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Multiplier Meat-Type Chicken Breeding Flocks and Products § 145.34 Terminology and...

  9. 9 CFR 145.7 - Specific provisions for participating dealers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... dealers. 145.7 Section 145.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.7 Specific provisions for participating dealers. Dealers in poultry breeding...

  10. 9 CFR 145.12 - Inspections.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Inspections. 145.12 Section 145.12 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.12...

  11. 9 CFR 145.11 - Supervision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Supervision. 145.11 Section 145.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.11...

  12. 9 CFR 145.44 - Terminology and classification; States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... 145.44 Section 145.44 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Turkey Breeding Flocks and Products § 145.44 Terminology and classification; States...

  13. 9 CFR 145.34 - Terminology and classification; States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... 145.34 Section 145.34 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Multiplier Meat-Type Chicken Breeding Flocks and Products § 145.34 Terminology and...

  14. 7 CFR 762.145 - Restructuring guaranteed loans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Restructuring guaranteed loans. 762.145 Section 762.145 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.145 Restructuring guaranteed loans. (a...

  15. 9 CFR 145.7 - Specific provisions for participating dealers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... dealers. 145.7 Section 145.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.7 Specific provisions for participating dealers. Dealers in poultry breeding...

  16. 9 CFR 145.7 - Specific provisions for participating dealers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... dealers. 145.7 Section 145.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.7 Specific provisions for participating dealers. Dealers in poultry breeding...

  17. 9 CFR 145.7 - Specific provisions for participating dealers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... dealers. 145.7 Section 145.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.7 Specific provisions for participating dealers. Dealers in poultry breeding...

  18. 24 CFR 572.145 - Displacement prohibited; protection of nonpurchasing residents.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Displacement prohibited; protection of nonpurchasing residents. 572.145 Section 572.145 Housing and Urban Development Regulations... § 572.145 Displacement prohibited; protection of nonpurchasing residents. (a) Displacement prohibited...

  19. 24 CFR 572.145 - Displacement prohibited; protection of nonpurchasing residents.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Displacement prohibited; protection of nonpurchasing residents. 572.145 Section 572.145 Housing and Urban Development Regulations... § 572.145 Displacement prohibited; protection of nonpurchasing residents. (a) Displacement prohibited...

  20. 24 CFR 572.145 - Displacement prohibited; protection of nonpurchasing residents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Displacement prohibited; protection of nonpurchasing residents. 572.145 Section 572.145 Housing and Urban Development Regulations... § 572.145 Displacement prohibited; protection of nonpurchasing residents. (a) Displacement prohibited...

  1. 24 CFR 572.145 - Displacement prohibited; protection of nonpurchasing residents.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Displacement prohibited; protection of nonpurchasing residents. 572.145 Section 572.145 Housing and Urban Development Regulations... § 572.145 Displacement prohibited; protection of nonpurchasing residents. (a) Displacement prohibited...

  2. 24 CFR 572.145 - Displacement prohibited; protection of nonpurchasing residents.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Displacement prohibited; protection of nonpurchasing residents. 572.145 Section 572.145 Housing and Urban Development Regulations... § 572.145 Displacement prohibited; protection of nonpurchasing residents. (a) Displacement prohibited...

  3. 40 CFR 145.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Definitions. 145.2 Section 145.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS General Program Requirements § 145.2 Definitions. The definitions of part 144 apply...

  4. 40 CFR 145.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Definitions. 145.2 Section 145.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS General Program Requirements § 145.2 Definitions. The definitions of part 144 apply...

  5. 7 CFR 1703.145 - Application selection provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Application selection provisions. 1703.145 Section 1703.145 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.145...

  6. 7 CFR 1703.145 - Application selection provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Application selection provisions. 1703.145 Section 1703.145 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.145...

  7. 7 CFR 1703.145 - Application selection provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Application selection provisions. 1703.145 Section 1703.145 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.145...

  8. 7 CFR 1703.145 - Application selection provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Application selection provisions. 1703.145 Section 1703.145 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.145...

  9. 7 CFR 65.145 - Ginseng.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Ginseng. 65.145 Section 65.145 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.145 Ginseng. Ginseng means ginseng root of the genus...

  10. 7 CFR 65.145 - Ginseng.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Ginseng. 65.145 Section 65.145 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.145 Ginseng. Ginseng means ginseng root of the genus...

  11. Austenitic stainless steel for high temperature applications

    DOEpatents

    Johnson, Gerald D.; Powell, Roger W.

    1985-01-01

    This invention describes a composition for an austenitic stainless steel which has been found to exhibit improved high temperature stress rupture properties. The composition of this alloy is about (in wt. %): 12.5 to 14.5 Cr; 14.5 to 16.5 Ni; 1.5 to 2.5 Mo; 1.5 to 2.5 Mn; 0.1 to 0.4 Ti; 0.02 to 0.08 C; 0.5 to 1.0 Si; 0.01 maximum, N; 0.02 to 0.08 P; 0.002 to 0.008 B; 0.004-0.010 S; 0.02-0.05 Nb; 0.01-0.05 V; 0.005-0.02 Ta; 0.02-0.05 Al; 0.01-0.04 Cu; 0.02-0.05 Co; 0.03 maximum, As; 0.01 maximum, O; 0.01 maximum, Zr; and with the balance of the alloy being essentially iron. The carbon content of the alloy is adjusted such that wt. % Ti/(wt. % C+wt. % N) is between 4 and 6, and most preferably about 5. In addition the sum of the wt. % P+wt. % B+wt. % S is at least 0.03 wt. %. This alloy is believed to be particularly well suited for use as fast breeder reactor fuel element cladding.

  12. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk.

    PubMed

    Leung, Yuet-Kin; Gao, Ying; Lau, Kin-Mang; Zhang, Xiang; Ho, Shuk-Mei

    2006-04-01

    Estrogen receptor (ER)-beta is the predominant ER subtype in prostate cancer (PCa). We previously demonstrated that ICI 182,780 (ICI), but not estrogens, exerted dose-dependent growth inhibition on DU145 PCa cells by an ER-beta-mediated pathway. Transcriptional profiling detected a greater than three-fold upregulation of seven genes after a 12-hour exposure to 1 microM ICI. Semiquantitative reverse transcriptase polymerase chain reaction confirmed the upregulation of four genes by ICI: interleukin-12alpha chain, interleukin-8, embryonic growth/differentiation factor, and RYK tyrosine kinase. Treatment with an ER-beta antisense oligonucleotide reduced cellular ER-beta mRNA and induced loss of expression of these genes. Sequence analysis revealed the presence of consensus NFkappaB sites, but not estrogen-responsive elements, in promoters of all four genes. Reporter assay and chromatin immunoprecipitation experiments demonstrated that ICI-induced gene expression could be mediated by crosstalk between ER-beta and the NFkappaB signaling pathway, denoting a novel mechanism of ER-beta-mediated ICI action. Therefore, combined therapies targeting ER-beta and NFkappaB signaling may be synergistic as treatment for PCa.

  13. ICI 182,780-Regulated Gene Expression in DU145 Prostate Cancer Cells Is Mediated by Estrogen Receptor-β/NFκB Crosstalk1

    PubMed Central

    Leung, Yuet-Kin; Gao, Ying; Lau, Kin-Mang; Zhang, Xiang; Ho, Shuk-Mei

    2006-01-01

    Abstract Estrogen receptor (ER)-β is the predominant ER subtype in prostate cancer (PCa). We previously demonstrated that ICI 182,780 (ICI), but not estrogens, exerted dose-dependent growth inhibition on DU145 PCa cells by an ER-β-mediated pathway. Transcriptional profiling detected a greater than three-fold upregulation of seven genes after a 12-hour exposure to 1 µM ICI. Semi-quantitative reverse transcriptase polymerase chain reaction confirmed the upregulation of four genes by ICI: interleukin-12α chain, interleukin-8, embryonic growth/differentiation factor, and RYK tyrosine kinase. Treatment with an ER-β antisense oligonucleotide reduced cellular ER-β mRNA and induced loss of expression of these genes. Sequence analysis revealed the presence of consensus NFκB sites, but not estrogen-responsive elements, in promoters of all four genes. Reporter assay and chromatin immunoprecipitation experiments demonstrated that ICI-induced gene expression could be mediated by crosstalk between ER-α and the NFκB signaling pathway, denoting a novel mechanism of ER-β-mediated ICI action. Therefore, combined therapies targeting ER-β and NFκB signaling may be synergistic as treatment for PCa. PMID:16756716

  14. MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Zhigang; Zhang, Xiaoping; Yang, Zhili

    2012-10-26

    Highlights: Black-Right-Pointing-Pointer MiR-145 targets a putative binding site in the 3 Prime UTR of PAK4. Black-Right-Pointing-Pointer MiR-145 played an important role in inhibiting cell growth by directly targeting PAK4. Black-Right-Pointing-Pointer MiR-145 may function as tumor suppressors. -- Abstract: MicroRNAs (miRNAs) are regulators of numerous cellular events; accumulating evidence indicates that miRNAs play a key role in a wide range of biological functions, such as cellular proliferation, differentiation, and apoptosis in cancer. Down-regulated expression of miR-145 has been reported in colon cancer tissues and cell lines. The molecular mechanisms underlying miR-145 and the regulation of colon carcinogenesis remain unclear. In thismore » study, we investigated the levels of miR-145 in human colon cancer cells using qRT-PCR and found markedly decreased levels compared to normal epithelial cells. We identified PAK4 as a novel target of miR-145 using informatics screening. Additionally, we demonstrated that miR-145 targets a putative binding site in the 3 Prime UTR of PAK4 and that its abundance is inversely associated with miR-145 expression in colon cancer cells; we confirmed this relationship using the luciferase reporter assay. Furthermore, restoration of miR-145 by mimics in SW620 cells significantly attenuated cell growth in vitro, in accordance with the inhibitory effects induced by siRNA mediated knockdown of PAK4. Taken together, these findings demonstrate that miR-145 downregulates P-ERK expression by targeting PAK4 and leads to inhibition of tumor growth.« less

  15. Metabolism of inositol(1,4,5)trisphosphate by a soluble enzyme fraction from pea (Pisum sativum) roots

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Drobak, B.K.; Watkins, P.A.C.; Roberts, K.

    1991-02-01

    Metabolism of the putative messenger molecule D-myo-inositol(1,4,5)trisphosphate (Ins(1,4,5)P{sub 3}) in plant cells has been studied using a soluble fraction from pea (pisum sativum) roots as enzyme source and (5-{sup 32}P)Ins(1,4,5)P{sub 3} and (2-{sup 3}H)Ins(1,4,5)P{sub 3} as tracers. Ins(1,4,5)P{sub 3} was rapidly converted into both lower and higher inositol phosphates. The major dephosphorylation product was inositol (4,5) bisphosphate (Ins(4,5)P{sub 2}) whereas inositol(1,4)bisphosphate (Ins(1,4)P{sub 2}) was only present in very small quantities throughout a 15 minute incubation period. In addition to these compounds, small amounts of nine other metabolites were produced including inositol and inositol(1,4,5,X)P{sub 4}. Dephosphorylation of Ins(1,4,5)P{sub 3} to Ins(4,5)P{submore » 2} was dependent on Ins(1,4,5)P{sub 3} concentration and was partially inhibited by the phosphohydrolase inhibitors 2,3-diphosphoglycerate, glucose 6-phosphate, and p-nitrophenylphosphate. Conversion of Ins(1,4,5)P{sub 3} to Ins(4,5)P{sub 2} and Ins(1,4,5,X)P{sub 4} was inhibited by 55 micromolar Ca{sup 2+}. This study demonstrates that enzymes are present in plant tissues which are capable of rapidly converting Ins(1,4,5)P{sub 3} and that pathways of inositol phosphate metabolism exist which may prove to be unique to the plant kingdom.« less

  16. miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.

    PubMed

    Götte, M; Mohr, C; Koo, C-Y; Stock, C; Vaske, A-K; Viola, M; Ibrahim, S A; Peddibhotla, S; Teng, Y H-F; Low, J-Y; Ebnet, K; Kiesel, L; Yip, G W

    2010-12-16

    Micro RNAs are small non-coding RNAs, which regulate fundamental cellular and developmental processes at the transcriptional and translational level. In breast cancer, miR-145 expression is downregulated compared with healthy control tissue. As several predicted targets of miR-145 potentially regulate cell motility, we aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. Assisted by Affymetrix array technology, we demonstrate that overexpression of miR-145 in MDA-MB-231, MCF-7, MDA-MB-468 and SK-BR-3 breast cancer cells and in Ishikawa endometrial carcinoma cells leads to a downregulation of the cell-cell adhesion protein JAM-A and of the actin bundling protein fascin. Moreover, podocalyxin and Serpin E1 mRNA levels were downregulated, and gamma-actin, transgelin and MYL9 were upregulated upon miR-145 overexpression. These miR-145-dependent expression changes drastically decreased cancer cell motility, as revealed by time-lapse video microscopy, scratch wound closure assays and matrigel invasion assays. Immunofluorescence microscopy demonstrated restructuring of the actin cytoskeleton and a change in cell morphology by miR-145 overexpression, resulting in a more cortical actin distribution, and reduced actin stress fiber and filopodia formation. Nuclear rotation was observed in 10% of the pre-miR-145 transfected MDA-MB-231 cells, accompanied by a reduction of perinuclear actin. Luciferase activation assays confirmed direct miR-145-dependent regulation of the 3'UTR of JAM-A, whereas siRNA-mediated knockdown of JAM-A expression resulted in decreased motility and invasiveness of MDA-MB-231 and MCF-7 breast cancer cells. Our data identify JAM-A and fascin as novel targets of miR-145, firmly establishing a role for miR-145 in modulating breast cancer cell motility. Our data provide a rationale for future miR-145-targeted approaches of antimetastatic cancer therapy.

  17. 33 CFR 104.145 - Maritime Security (MARSEC) Directive.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Maritime Security (MARSEC) Directive. 104.145 Section 104.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: VESSELS General § 104.145 Maritime Security (MARSEC...

  18. 33 CFR 105.145 - Maritime Security (MARSEC) Directive.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Maritime Security (MARSEC) Directive. 105.145 Section 105.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES General § 105.145 Maritime Security (MARSEC...

  19. 9 CFR 145.33 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and products. 145.33 Section 145.33 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Multiplier Meat-Type Chicken Breeding Flocks and Products § 145.33...

  20. 9 CFR 145.43 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and products. 145.43 Section 145.43 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Turkey Breeding Flocks and Products § 145.43 Terminology and classification...

  1. 9 CFR 145.43 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and products. 145.43 Section 145.43 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Turkey Breeding Flocks and Products § 145.43 Terminology and classification...

  2. 14 CFR 125.145 - Firewall construction.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Firewall construction. 125.145 Section 125.145 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Requirements § 125.145 Firewall construction. Each firewall and shroud must— (a) Be so made that no hazardous...

  3. 14 CFR 125.145 - Firewall construction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Firewall construction. 125.145 Section 125.145 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Requirements § 125.145 Firewall construction. Each firewall and shroud must— (a) Be so made that no hazardous...

  4. 22 CFR 145.37 - Property trust relationship.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Property trust relationship. 145.37 Section 145.37 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF... Standards § 145.37 Property trust relationship. Real property, equipment, intangible property and debt...

  5. 49 CFR 176.145 - Segregation in single hold vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Segregation in single hold vessels. 176.145 Section 176.145 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... VESSEL Detailed Requirements for Class 1 (Explosive) Materials Segregation § 176.145 Segregation in...

  6. 49 CFR 176.145 - Segregation in single hold vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Segregation in single hold vessels. 176.145 Section 176.145 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... VESSEL Detailed Requirements for Class 1 (Explosive) Materials Segregation § 176.145 Segregation in...

  7. 9 CFR 145.11 - Supervision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Supervision. 145.11 Section 145.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... sample collecting provided for in § 145.14 and may designate qualified persons as Authorized Testing...

  8. 9 CFR 145.11 - Supervision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Supervision. 145.11 Section 145.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... sample collecting provided for in § 145.14 and may designate qualified persons as Authorized Testing...

  9. 9 CFR 145.11 - Supervision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Supervision. 145.11 Section 145.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... sample collecting provided for in § 145.14 and may designate qualified persons as Authorized Testing...

  10. 22 CFR 145.17 - Certifications and representations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certifications and representations. 145.17 Section 145.17 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 145.17...

  11. 22 CFR 145.71 - Closeout procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Closeout procedures. 145.71 Section 145.71 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS After-the-Award Requirements § 145.71 Closeout...

  12. 22 CFR 145.34 - Equipment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Equipment. 145.34 Section 145.34 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.34 Equipment...

  13. 22 CFR 145.48 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Contract clauses. 145.48 Section 145.48 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 145.48...

  14. 22 CFR 145.47 - Contract administration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Contract administration. 145.47 Section 145.47 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 145...

  15. 22 CFR 145.4 - Deviations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Deviations. 145.4 Section 145.4 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.4 Deviations. The Office of Management and...

  16. 22 CFR 145.43 - Competition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Competition. 145.43 Section 145.43 Foreign..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 145.43 Competition. All procurement transactions shall be conducted in a manner to provide, to the maximum extent...

  17. 47 CFR 14.5 - Waivers-Multipurpose Services and Equipment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Waivers-Multipurpose Services and Equipment. 14.5 Section 14.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Scope § 14.5 Waivers—Multipurpose Services and...

  18. 47 CFR 14.5 - Waivers-Multipurpose Services and Equipment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Waivers-Multipurpose Services and Equipment. 14.5 Section 14.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Scope § 14.5 Waivers—Multipurpose Services and...

  19. 47 CFR 14.5 - Waivers-Multipurpose Services and Equipment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Waivers-Multipurpose Services and Equipment. 14.5 Section 14.5 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Scope § 14.5 Waivers—Multipurpose Services and...

  20. microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells.

    PubMed

    Sathyanarayanan, Anusha; Chandrasekaran, Karthik Subramanian; Karunagaran, Devarajan

    2017-04-01

    Previously, it has been reported that microRNA-145 (miR-145) is lowly expressed in human cervical cancers and that its putative tumour suppressive role may be attributed to epithelial-mesenchymal transition (EMT) regulation. Here, we aimed to assess whether miR-145 may affect EMT-associated markers/genes and suppress cervical cancer growth and motility, and to provide a mechanistic basis for these phenomena. The identification of the SMAD-interacting protein 1 (SIP1) mRNA as putative miR-145 target was investigated using a 3' untranslated region (3'UTR) luciferase assay and Western blotting, respectively. The functional effects of exogenous miR-145 expression, miR-145 suppression or siRNA-mediated SIP1 expression down-regulation in cervical cancer-derived C33A and SiHa cells were analysed using Western blotting, BrdU incorporation (proliferation), transwell migration and invasion assays. In addition, the expression levels of miR-145 and SIP1 were determined in primary human cervical cancer and non-cancer tissue samples using qRT-PCR. We found that miR-145 binds to the wild-type 3'UTR of SIP1, but not to its mutant counterpart, and that, through this binding, miR-145 can effectively down-regulate SIP1 expression. In addition, we found that exogenous miR-145 expression or siRNA-mediated down-regulation of SIP1 expression attenuates the proliferation, migration and invasion of C33A and SiHa cells and alters the expression of the EMT-associated markers CDH1, VIM and SNAI1, whereas inhibition of endogenous miR-145 expression elicited the opposite effects. The expression of miR-145 in cervical cancer tissue samples was found to be low, while that of SIP1 was found to be high compared to non-cancerous cervical tissues. An inverse expression correlation between the two was substantiated through the anlaysis of data deposited in the TCGA database. Our data indicate that low miR-145 expression levels in conjunction with elevated SIP1 expression levels may contribute to cervical cancer development. MiR-145-mediated regulation of SIP1 provides a novel mechanistic basis for its tumour suppressive mode of action in human cervical cancer cells.

  1. 9 CFR 145.63 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and products. 145.63 Section 145.63 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Ostrich, Emu, Rhea, and Cassowary Breeding Flocks and Products § 145.63...

  2. 9 CFR 145.63 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and products. 145.63 Section 145.63 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY Special Provisions for Ostrich, Emu, Rhea, and Cassowary Breeding Flocks and Products § 145.63...

  3. 40 CFR 145.58 - Procedure for processing an Indian Tribe's application.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Tribe's application. 145.58 Section 145.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Indian Tribes § 145.58 Procedure for processing an Indian Tribe's application. (a) The Administrator shall process a completed application of an...

  4. 40 CFR 145.58 - Procedure for processing an Indian Tribe's application.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Tribe's application. 145.58 Section 145.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Indian Tribes § 145.58 Procedure for processing an Indian Tribe's application. (a) The Administrator shall process a completed application of an...

  5. 40 CFR 145.58 - Procedure for processing an Indian Tribe's application.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Tribe's application. 145.58 Section 145.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Indian Tribes § 145.58 Procedure for processing an Indian Tribe's application. (a) The Administrator shall process a completed application of an...

  6. 4 CFR 28.145 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Policy. 28.145 Section 28.145 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL APPEALS BOARD; PROCEDURES APPLICABLE TO CLAIMS CONCERNING EMPLOYMENT PRACTICES AT THE GOVERNMENT ACCOUNTABILITY OFFICE Ex Parte Communications § 28.145 Policy. It is the...

  7. 7 CFR 457.145 - Potato crop insurance-certified seed endorsement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Potato crop insurance-certified seed endorsement. 457.145 Section 457.145 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.145 Potato crop...

  8. 45 CFR 400.145 - Opportunity to apply for services.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Opportunity to apply for services. 400.145 Section 400.145 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Applications, Determinations of Eligibility, and Provision of Services § 400.145...

  9. 45 CFR 400.145 - Opportunity to apply for services.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Opportunity to apply for services. 400.145 Section 400.145 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Applications, Determinations of Eligibility, and Provision of Services § 400.145...

  10. 45 CFR 400.145 - Opportunity to apply for services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Opportunity to apply for services. 400.145 Section 400.145 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Applications, Determinations of Eligibility, and Provision of Services § 400.145...

  11. 45 CFR 400.145 - Opportunity to apply for services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Opportunity to apply for services. 400.145 Section 400.145 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Applications, Determinations of Eligibility, and Provision of Services § 400.145...

  12. 45 CFR 400.145 - Opportunity to apply for services.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Opportunity to apply for services. 400.145 Section 400.145 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT... Refugee Social Services Applications, Determinations of Eligibility, and Provision of Services § 400.145...

  13. 17 CFR 230.145 - Reclassification of securities, mergers, consolidations and acquisitions of assets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., mergers, consolidations and acquisitions of assets. 230.145 Section 230.145 Commodity and Securities... § 230.145 Reclassification of securities, mergers, consolidations and acquisitions of assets.... A statutory merger or consolidation or similar plan or acquisition in which securities of such...

  14. 14 CFR 145.217 - Contract maintenance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Contract maintenance. 145.217 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.217 Contract maintenance. (a) A certificated repair station may contract a maintenance function pertaining to an article to an...

  15. 40 CFR 440.145-440.147 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false [Reserved] 440.145-440.147 Section 440.145-440.147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold Placer Mine Subcategory §§ 440.145...

  16. 40 CFR 440.145-440.147 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false [Reserved] 440.145-440.147 Section 440.145-440.147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold Placer Mine Subcategory §§ 440.145...

  17. 22 CFR 145.32 - Real property.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Real property. 145.32 Section 145.32 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.32 Real...

  18. 22 CFR 145.14 - Special award conditions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Special award conditions. 145.14 Section 145.14 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 145.14 Special award...

  19. 22 CFR 145.13 - Debarment and suspension.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Debarment and suspension. 145.13 Section 145.13 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 145.13 Debarment and...

  20. 14 CFR 145.109 - Equipment, materials, and data requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Equipment, materials, and data requirements. 145.109 Section 145.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.109 Equipment, materials, and data requirements. (a) Except as otherwise...

  1. 14 CFR 145.109 - Equipment, materials, and data requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Equipment, materials, and data requirements. 145.109 Section 145.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.109 Equipment, materials, and data requirements. (a) Except as otherwise...

  2. 14 CFR 145.109 - Equipment, materials, and data requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Equipment, materials, and data requirements. 145.109 Section 145.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.109 Equipment, materials, and data requirements. (a) Except as otherwise...

  3. 14 CFR 145.109 - Equipment, materials, and data requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Equipment, materials, and data requirements. 145.109 Section 145.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.109 Equipment, materials, and data requirements. (a) Except as otherwise...

  4. 14 CFR 145.109 - Equipment, materials, and data requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Equipment, materials, and data requirements. 145.109 Section 145.109 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.109 Equipment, materials, and data requirements. (a) Except as otherwise...

  5. 28 CFR 0.145 - Overtime pay.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Overtime pay. 0.145 Section 0.145... Respect to Personnel and Certain Administrative Matters § 0.145 Overtime pay. The Director of the Federal... Attorney General may prescribe, authorize overtime pay (including additional compensation in lieu of...

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression ofmore » miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.« less

  7. Assessment of essential and nonessential dietary exposure to trace elements from homegrown foodstuffs in a polluted area in Makedonska Kamenica and the Kočani region (FYRM).

    PubMed

    Vrhovnik, Petra; Dolenec, Matej; Serafimovski, Todor; Tasev, Goran; Arrebola, Juan P

    2016-07-15

    The main purpose of the present study is to assess human dietary exposure to essential and non-essential trace elements via consumption of selected homegrown foodstuffs. Twelve essential and non-essential trace elements (Cd, Co, Cu, Cr, Hg, Mo, Ni, Pb, Sb, Se, Zn and As) were detected in various homegrown foodstuffs. Detailed questionnaires were also applied among a sample of the local population to collect information on sociodemographic characteristics. The results of the present study clearly indicate that the majority of the trace elements are at highly elevated levels in the studied foodstuffs, in comparison to international recommendations. The maximum measured levels of ETE and NETE are as follows [μgkg(-1)]: Cd 873, Co 1370, Cu 21700, Cr 59633, Hg 26, Mo 6460, Ni14.5, Pb 11100, Sb 181, Se 0.30, Zn 102 and As 693. Additionally, age, body mass index and gender were significantly associated with levels of dietary exposure. Further research is warranted on the potential health implication of this exposure. The study merges the accumulation of ETE and NETE in home-grown foodstuffs and reflects considerably high health risks for inhabitants. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Methylation of miR-145a-5p promoter mediates adipocytes differentiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Du, Jingjing; Cheng, Xiao; Shen, Linyuan

    MicroRNAs (miRNAs, miR) play important roles in adipocyte development. Recent studies showed that the expression of several miRNAs is closely related with promoter methylation. However, it is not known whether miRNA mediates adipocytes differentiation by means of DNA methylation. Here, we showed that miR-145a-5p was poorly expressed in adipose tissue from mice fed a high fat diet (HFD). Overexpression or inhibition of miR-145a-5p was unfavorable or beneficial, respectively, for adipogenesis, and these effects were achieved by regulating adipocyte-specific genes involved in lipogenic transcription, fatty acid synthesis, and fatty acid transportation. Particularly, we first suggested that miR-145a-5p mimics or inhibitors promotedmore » or repressed adipocytes proliferation by regulating p53 and p21, which act as cell cycle regulating factors. Surprisingly, the miR-145a-5p-repressed adipocyte differentiation was enhanced or rescued when cells treated with 5-Aza-dC were transfected with miR-145a-5p mimics or inhibitors, respectively. These data indicated that, as a new mean to positively regulate adipocyte proliferation, the process of miR-145a-5p-inhibited adipogenesis may be regulated by DNA methylation. -- Highlights: •MiR-145a-5p promotes adipocytes proliferation. •MiR-145a-5p is negatively correlated with obesity. •MiR-145a-5p mediates adipocytes differentiation via regulating pathway related adipocytes differentiation. MiR-145a-5p mediating adipocytes differentiation was regulated by DNA methylation.« less

  9. Glucocorticoid regulation of a novel HPV-E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells.

    PubMed

    Shi, Ming; Du, Libin; Liu, Dan; Qian, Lu; Hu, Meiru; Yu, Ming; Yang, Zhengyan; Zhao, Mingzhen; Chen, Changguo; Guo, Liang; Wang, Lina; Song, Lun; Ma, Yuanfang; Guo, Ning

    2012-10-01

    Glucocorticoids are stress-responsive neuroendocrine mediators and play an important role in malignant progression, especially in solid tumours. We demonstrate a novel mechanism by which glucocorticoids modulate p53-dependent miR-145 expression in HPV-positive cervical cancer cells through induction of E6 proteins. We found that expression of miR-145 was reduced in cervical cancer tissues. Cortisol induced HPV-E6 expression and suppressed p53 and miR-145 in cervical cancer cells. MiR-145 expression in cervical cancer cells was wild-type p53-dependent, and cortisol-induced down-regulation of miR-145 expression prevented chemotherapy-induced apoptosis, whereas over-expression of miR-145 enhanced sensitivity to mitomycin and reversed the chemoresistance induced by glucocorticoids. We also show that miR-145 augments the effects of p53 by suppressing the inhibitors of p53 in cervical cancer cells, suggesting that miR-145 plays a role in p53 tumour suppression. Finally, we demonstrate that miR-145 inhibits both the motility and invasion of cervical cancer cells. Our findings identify a novel pathway through which the neuroendocrine macroenvironment affects cervical tumour growth, invasion and therapy resistance and show that miR-145 may serve as a target for cervical cancer therapy. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  10. 22 CFR 145.32 - Real property.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Real property. 145.32 Section 145.32 Foreign..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.32 Real... disposition of real property acquired in whole or in part under awards. Unless otherwise provided by statute...

  11. 22 CFR 145.32 - Real property.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Real property. 145.32 Section 145.32 Foreign..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.32 Real... disposition of real property acquired in whole or in part under awards. Unless otherwise provided by statute...

  12. 22 CFR 145.32 - Real property.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Real property. 145.32 Section 145.32 Foreign..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.32 Real... disposition of real property acquired in whole or in part under awards. Unless otherwise provided by statute...

  13. 22 CFR 145.32 - Real property.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Real property. 145.32 Section 145.32 Foreign..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property Standards § 145.32 Real... disposition of real property acquired in whole or in part under awards. Unless otherwise provided by statute...

  14. 14 CFR 145.163 - Training requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Training requirements. 145.163 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Personnel § 145.163 Training requirements. (a) A certificated repair station must have an employee training program approved by the FAA that consists of initial...

  15. 22 CFR 145.20 - Purpose of financial and program management.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose of financial and program management... Financial and Program Management § 145.20 Purpose of financial and program management. Sections 145.21 through 145.28 prescribe standards for financial management systems, methods for making payments and rules...

  16. 9 CFR 145.15 - Diagnostic surveillance program for low pathogenic avian influenza.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Diagnostic surveillance program for low pathogenic avian influenza. 145.15 Section 145.15 Animals and Animal Products ANIMAL AND PLANT... PLAN FOR BREEDING POULTRY General Provisions § 145.15 Diagnostic surveillance program for low...

  17. 9 CFR 145.15 - Diagnostic surveillance program for low pathogenic avian influenza.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Diagnostic surveillance program for low pathogenic avian influenza. 145.15 Section 145.15 Animals and Animal Products ANIMAL AND PLANT... PLAN FOR BREEDING POULTRY General Provisions § 145.15 Diagnostic surveillance program for low...

  18. 19 CFR 145.52 - Literature concerning devices for unlawful abortion.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... abortion. 145.52 Section 145.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... § 145.52 Literature concerning devices for unlawful abortion. Mail articles containing literature or advertisements concerning devices to produce unlawful abortions, are prohibited from the mails by 18 U.S.C. 1461...

  19. 27 CFR 25.145 - Tanks, vehicles, and vessels.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Tanks, vehicles, and vessels. 25.145 Section 25.145 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Marks, Brands, and Labels § 25.145 Tanks, vehicles, and...

  20. 7 CFR 14.5 - Procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Procedure. 14.5 Section 14.5 Agriculture Office of the Secretary of Agriculture DETERMINING THE PRIMARY PURPOSE OF CERTAIN PAYMENTS FOR FEDERAL TAX PURPOSES § 14.5... purpose of conserving soil and water resources, protecting or restoring the environment, improving forests...

  1. 19 CFR 145.36 - Articles for institutions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Articles for institutions. 145.36 Section 145.36... TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.36 Articles for institutions. Books and other articles classifiable under subheading 4903.00.00, 4904.00.00, 4905.91.00, 4905.99.00...

  2. 19 CFR 145.36 - Articles for institutions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Articles for institutions. 145.36 Section 145.36... TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.36 Articles for institutions. Books and other articles classifiable under subheading 4903.00.00, 4904.00.00, 4905.91.00, 4905.99.00...

  3. 19 CFR 145.36 - Articles for institutions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Articles for institutions. 145.36 Section 145.36... TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.36 Articles for institutions. Books and other articles classifiable under subheading 4903.00.00, 4904.00.00, 4905.91.00, 4905.99.00...

  4. 19 CFR 145.36 - Articles for institutions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Articles for institutions. 145.36 Section 145.36... TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.36 Articles for institutions. Books and other articles classifiable under subheading 4903.00.00, 4904.00.00, 4905.91.00, 4905.99.00...

  5. 19 CFR 145.36 - Articles for institutions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Articles for institutions. 145.36 Section 145.36... TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.36 Articles for institutions. Books and other articles classifiable under subheading 4903.00.00, 4904.00.00, 4905.91.00, 4905.99.00...

  6. 46 CFR 108.145 - Hatches and tonnage openings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Hatches and tonnage openings. 108.145 Section 108.145... AND EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.145 Hatches and tonnage openings. Each hatch, except a hatch between storage spaces and each tonnage opening closure, must be made...

  7. 46 CFR 108.145 - Hatches and tonnage openings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Hatches and tonnage openings. 108.145 Section 108.145... AND EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.145 Hatches and tonnage openings. Each hatch, except a hatch between storage spaces and each tonnage opening closure, must be made...

  8. 46 CFR 108.145 - Hatches and tonnage openings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Hatches and tonnage openings. 108.145 Section 108.145... AND EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.145 Hatches and tonnage openings. Each hatch, except a hatch between storage spaces and each tonnage opening closure, must be made...

  9. 46 CFR 108.145 - Hatches and tonnage openings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Hatches and tonnage openings. 108.145 Section 108.145... AND EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.145 Hatches and tonnage openings. Each hatch, except a hatch between storage spaces and each tonnage opening closure, must be made...

  10. 46 CFR 108.145 - Hatches and tonnage openings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Hatches and tonnage openings. 108.145 Section 108.145... AND EQUIPMENT Construction and Arrangement Structural Fire Protection § 108.145 Hatches and tonnage openings. Each hatch, except a hatch between storage spaces and each tonnage opening closure, must be made...

  11. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable to...

  12. 21 CFR 1311.145 - Digitally signing the prescription with the individual practitioner's private key.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... individual practitioner's private key. 1311.145 Section 1311.145 Food and Drugs DRUG ENFORCEMENT... Prescriptions § 1311.145 Digitally signing the prescription with the individual practitioner's private key. (a... digitally sign a controlled substance prescription using the private key associated with his digital...

  13. 21 CFR 1311.145 - Digitally signing the prescription with the individual practitioner's private key.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... individual practitioner's private key. 1311.145 Section 1311.145 Food and Drugs DRUG ENFORCEMENT... Prescriptions § 1311.145 Digitally signing the prescription with the individual practitioner's private key. (a... digitally sign a controlled substance prescription using the private key associated with his digital...

  14. 21 CFR 1311.145 - Digitally signing the prescription with the individual practitioner's private key.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... individual practitioner's private key. 1311.145 Section 1311.145 Food and Drugs DRUG ENFORCEMENT... Prescriptions § 1311.145 Digitally signing the prescription with the individual practitioner's private key. (a... digitally sign a controlled substance prescription using the private key associated with his digital...

  15. 21 CFR 1311.145 - Digitally signing the prescription with the individual practitioner's private key.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... individual practitioner's private key. 1311.145 Section 1311.145 Food and Drugs DRUG ENFORCEMENT... Prescriptions § 1311.145 Digitally signing the prescription with the individual practitioner's private key. (a... digitally sign a controlled substance prescription using the private key associated with his digital...

  16. 27 CFR 25.145 - Tanks, vehicles, and vessels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Tanks, vehicles, and vessels. 25.145 Section 25.145 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Marks, Brands, and Labels § 25.145 Tanks, vehicles, and...

  17. 33 CFR 106.145 - Right to appeal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Right to appeal. 106.145 Section 106.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARINE SECURITY: OUTER CONTINENTAL SHELF (OCS) FACILITIES General § 106.145 Right to appeal. Any person...

  18. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable to...

  19. 29 CFR 4.145 - Extended term contracts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Extended term contracts. 4.145 Section 4.145 Labor Office...'Hara Service Contract Act Changes in Contract Coverage § 4.145 Extended term contracts. (a) Sometimes service contracts are entered into for an extended term exceeding one year; however, their continuation in...

  20. 29 CFR 4.145 - Extended term contracts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Extended term contracts. 4.145 Section 4.145 Labor Office...'Hara Service Contract Act Changes in Contract Coverage § 4.145 Extended term contracts. (a) Sometimes service contracts are entered into for an extended term exceeding one year; however, their continuation in...

  1. 29 CFR 4.145 - Extended term contracts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Extended term contracts. 4.145 Section 4.145 Labor Office...'Hara Service Contract Act Changes in Contract Coverage § 4.145 Extended term contracts. (a) Sometimes service contracts are entered into for an extended term exceeding one year; however, their continuation in...

  2. 49 CFR 37.145 - State comment on plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false State comment on plans. 37.145 Section 37.145 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Paratransit as a Complement to Fixed Route Service § 37.145 State comment on plans. Each...

  3. 19 CFR 145.52 - Literature concerning devices for unlawful abortion.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... abortion. 145.52 Section 145.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... § 145.52 Literature concerning devices for unlawful abortion. Mail articles containing literature or advertisements concerning devices to produce unlawful abortions, are prohibited from the mails by 18 U.S.C. 1461...

  4. 19 CFR 145.52 - Literature concerning devices for unlawful abortion.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... abortion. 145.52 Section 145.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... § 145.52 Literature concerning devices for unlawful abortion. Mail articles containing literature or advertisements concerning devices to produce unlawful abortions, are prohibited from the mails by 18 U.S.C. 1461...

  5. 19 CFR 145.52 - Literature concerning devices for unlawful abortion.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... abortion. 145.52 Section 145.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... § 145.52 Literature concerning devices for unlawful abortion. Mail articles containing literature or advertisements concerning devices to produce unlawful abortions, are prohibited from the mails by 18 U.S.C. 1461...

  6. 19 CFR 145.52 - Literature concerning devices for unlawful abortion.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... abortion. 145.52 Section 145.52 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... § 145.52 Literature concerning devices for unlawful abortion. Mail articles containing literature or advertisements concerning devices to produce unlawful abortions, are prohibited from the mails by 18 U.S.C. 1461...

  7. 21 CFR 133.145 - Granular cheese for manufacturing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Granular cheese for manufacturing. 133.145 Section 133.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Standardized Cheese and Related Products § 133.145 Granular cheese for manufacturing. Granular cheese for...

  8. 32 CFR 842.145 - Delegation of authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Delegation of authority. 842.145 Section 842.145 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE CLAIMS AND LITIGATION ADMINISTRATIVE CLAIMS Advance Payments (10 U.S.C. 2736) § 842.145 Delegation of authority. (a) The Secretary of...

  9. 19 CFR 145.23 - Time limits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Time limits. 145.23 Section 145.23 Customs Duties... (CONTINUED) MAIL IMPORTATIONS Administrative Review of Mail Entries § 145.23 Time limits. A mail entry made.... 1520(c)), only if the addressee requests such amendment within the time limits prescribed therein (see...

  10. 19 CFR 145.23 - Time limits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Time limits. 145.23 Section 145.23 Customs Duties... (CONTINUED) MAIL IMPORTATIONS Administrative Review of Mail Entries § 145.23 Time limits. A mail entry made.... 1520(c)), only if the addressee requests such amendment within the time limits prescribed therein (see...

  11. 14 CFR 145.209 - Repair station manual contents.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; (g) Procedures for maintenance, preventive maintenance, or alterations performed under § 145.205; (h)Procedures for— (1) Maintaining and revising the contract maintenance information required by § 145.217(a)(2...) Maintaining and revising the contract maintenance information required by § 145.217(a)(2)(ii) and notifying...

  12. 10 CFR 600.145 - Cost and price analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Cost and price analysis. 600.145 Section 600.145 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Uniform Administrative... Nonprofit Organizations Post-Award Requirements § 600.145 Cost and price analysis. Some form of cost or...

  13. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory Research...

  14. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory Research...

  15. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory Research...

  16. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory Research...

  17. 10 CFR 1.45 - Office of Nuclear Regulatory Research.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Office of Nuclear Regulatory Research. 1.45 Section 1.45 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters Program Offices § 1.45 Office of Nuclear Regulatory Research. The Office of Nuclear Regulatory Research...

  18. 22 CFR 145.73 - Collection of amounts due.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Collection of amounts due. 145.73 Section 145.73 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS After-the-Award Requirements § 145.73...

  19. 22 CFR 145.3 - Effect on other issuances.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Effect on other issuances. 145.3 Section 145.3 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS General § 145.3 Effect on other issuances. For...

  20. 22 CFR 145.11 - Pre-award policies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Pre-award policies. 145.11 Section 145.11 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Pre-Award Requirements § 145.11 Pre-award policies...

  1. 14 CFR 382.145 - What records concerning training must carriers retain?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false What records concerning training must carriers retain? 382.145 Section 382.145 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.145 What records concerning training must carriers...

  2. 14 CFR 382.145 - What records concerning training must carriers retain?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false What records concerning training must carriers retain? 382.145 Section 382.145 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.145 What records concerning training must carriers...

  3. 14 CFR 145.105 - Change of location, housing, or facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Change of location, housing, or facilities. 145.105 Section 145.105 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.105 Change of location, housing, or facilities. (a) A certificated repair station...

  4. 14 CFR 145.105 - Change of location, housing, or facilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Change of location, housing, or facilities. 145.105 Section 145.105 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.105 Change of location, housing, or facilities. (a) A certificated repair station...

  5. 14 CFR 145.105 - Change of location, housing, or facilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Change of location, housing, or facilities. 145.105 Section 145.105 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.105 Change of location, housing, or facilities. (a) A certificated repair station...

  6. 14 CFR 145.105 - Change of location, housing, or facilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Change of location, housing, or facilities. 145.105 Section 145.105 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.105 Change of location, housing, or facilities. (a) A certificated repair station...

  7. 14 CFR 145.105 - Change of location, housing, or facilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Change of location, housing, or facilities. 145.105 Section 145.105 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.105 Change of location, housing, or facilities. (a) A certificated repair station...

  8. 22 CFR 145.37 - Property trust relationship.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Property trust relationship. 145.37 Section 145... Standards § 145.37 Property trust relationship. Real property, equipment, intangible property and debt instruments that are acquired or improved with Federal funds shall be held in trust by the recipient as...

  9. 14 CFR 382.145 - What records concerning training must carriers retain?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false What records concerning training must carriers retain? 382.145 Section 382.145 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.145 What records concerning training must carriers...

  10. 14 CFR 382.145 - What records concerning training must carriers retain?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false What records concerning training must carriers retain? 382.145 Section 382.145 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.145 What records concerning training must carriers...

  11. 14 CFR 382.145 - What records concerning training must carriers retain?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false What records concerning training must carriers retain? 382.145 Section 382.145 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF... TRAVEL Training and Administrative Provisions § 382.145 What records concerning training must carriers...

  12. 41 CFR 102-117.145 - What are coastwise laws?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What are coastwise laws? 102-117.145 Section 102-117.145 Public Contracts and Property Management Federal Property Management... Restrictions That Affect International Transportation of Freight and Household Goods § 102-117.145 What are...

  13. 41 CFR 102-117.145 - What are coastwise laws?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are coastwise laws? 102-117.145 Section 102-117.145 Public Contracts and Property Management Federal Property Management... Restrictions That Affect International Transportation of Freight and Household Goods § 102-117.145 What are...

  14. 76 FR 64785 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ...--Internal, of Chapter 5, Time Limits Maintenance Checks, of EMBRAER EMB145 Aircraft Maintenance Manual, Part...--Tail Cone Fairing--Internal, of Chapter 5, Time Limits Maintenance Checks, of EMBRAER EMB145 Aircraft... Maintenance Checks, of EMBRAER EMB145 Aircraft Maintenance Manual, Part II, AMM-145/1124, Revision 54, dated...

  15. 19 CFR Appendix to Part 145 - Unknown Title

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Appendix to Part 145 Customs Duties U.S. CUSTOMS... IMPORTATIONS Pt. 145, App. Appendix to Part 145 A. Scope. The Customs Service is authorized to examine, with certain exceptions for diplomatic and governmental mail, all mail arriving from outside the Customs...

  16. 19 CFR Appendix to Part 145 - Unknown Title

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Appendix to Part 145 Customs Duties U.S. CUSTOMS... IMPORTATIONS Pt. 145, App. Appendix to Part 145 A. Scope. The Customs Service is authorized to examine, with certain exceptions for diplomatic and governmental mail, all mail arriving from outside the Customs...

  17. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  18. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  19. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  20. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  1. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  2. 22 CFR 145.26 - Non-Federal audits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Non-Federal audits. 145.26 Section 145.26 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 145.26 Non-Federal audits. (a)...

  3. 19 CFR 145.32 - Bona-fide gifts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Bona-fide gifts. 145.32 Section 145.32 Customs... (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.32 Bona-fide gifts. The port director... as bona-fide gifts from persons in foreign countries to persons in the United States having an...

  4. 12 CFR 252.145 - Mid-cycle stress test.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Mid-cycle stress test. 252.145 Section 252.145... (CONTINUED) ENHANCED PRUDENTIAL STANDARDS (REGULATION YY) Company-Run Stress Test Requirements for Covered Companies § 252.145 Mid-cycle stress test. (a) Mid-cycle stress test requirement. In addition to the stress...

  5. 12 CFR 252.145 - Mid-cycle stress test.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Mid-cycle stress test. 252.145 Section 252.145... (CONTINUED) ENHANCED PRUDENTIAL STANDARDS (REGULATION YY) Company-Run Stress Test Requirements for Covered Companies § 252.145 Mid-cycle stress test. (a) Mid-cycle stress test requirement. In addition to the stress...

  6. 12 CFR 145.91 - Home office.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Home office. 145.91 Section 145.91 Banks and... § 145.91 Home office. (a) All operations of a Federal savings association (“you”) are subject to direction from the home office. (b) You must notify the appropriate OCC licensing office if the permanent...

  7. 12 CFR 145.91 - Home office.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Home office. 145.91 Section 145.91 Banks and... § 145.91 Home office. (a) All operations of a Federal savings association (“you”) are subject to direction from the home office. (b) You must notify the appropriate OCC licensing office if the permanent...

  8. 12 CFR 145.91 - Home office.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Home office. 145.91 Section 145.91 Banks and... § 145.91 Home office. (a) All operations of a Federal savings association (“you”) are subject to direction from the home office. (b) You must notify the appropriate OCC licensing office if the permanent...

  9. 17 CFR 145.2 - Records available for public inspection and copying; documents published and indexed.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... inspection and copying; documents published and indexed. 145.2 Section 145.2 Commodity and Securities... for public inspection and copying; documents published and indexed. Except as provided in § 145.5... adopted by the Commission and are not published in the Federal Register; (d) Records released in response...

  10. 29 CFR 4.145 - Extended term contracts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Extended term contracts. 4.145 Section 4.145 Labor Office of...'Hara Service Contract Act Changes in Contract Coverage § 4.145 Extended term contracts. (a) Sometimes service contracts are entered into for an extended term exceeding one year; however, their continuation in...

  11. 29 CFR 4.145 - Extended term contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Extended term contracts. 4.145 Section 4.145 Labor Office of...'Hara Service Contract Act Changes in Contract Coverage § 4.145 Extended term contracts. (a) Sometimes service contracts are entered into for an extended term exceeding one year; however, their continuation in...

  12. 9 CFR 145.10 - Terminology and classification; flocks, products, and States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-Type Chickens. (See § 145.34(b).) EC10SE91.010 (k) U.S. Sanitation Monitored, Turkeys. (See § 145.43(f...).) ER21MR96.002 (n) U.S. M. Synoviae Clean State, Turkeys. (See § 145.44(d).) ER21MR96.003 (o) U.S. Salmonella...

  13. 9 CFR 145.10 - Terminology and classification; flocks, products, and States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-Type Chickens. (See § 145.34(b).) EC10SE91.010 (k) U.S. Sanitation Monitored, Turkeys. (See § 145.43(f...).) ER21MR96.002 (n) U.S. M. Synoviae Clean State, Turkeys. (See § 145.44(d).) ER21MR96.003 (o) U.S. Salmonella...

  14. 9 CFR 145.10 - Terminology and classification; flocks, products, and States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-Type Chickens. (See § 145.34(b).) EC10SE91.010 (k) U.S. Sanitation Monitored, Turkeys. (See § 145.43(f...).) ER21MR96.002 (n) U.S. M. Synoviae Clean State, Turkeys. (See § 145.44(d).) ER21MR96.003 (o) U.S. Salmonella...

  15. 26 CFR 145.4061-1 - Application to manufacturers tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Application to manufacturers tax. 145.4061-1...) MISCELLANEOUS EXCISE TAXES (CONTINUED) TEMPORARY EXCISE TAX REGULATIONS UNDER THE HIGHWAY REVENUE ACT OF 1982 (PUB. L. 97-424) § 145.4061-1 Application to manufacturers tax. The provisions of § 145.4051-1(e) (1...

  16. 31 CFR 363.145 - May I delete a pending transaction involving a zero-percent certificate of indebtedness?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... involving a zero-percent certificate of indebtedness? 363.145 Section 363.145 Money and Finance: Treasury... PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.145 May I delete a pending transaction involving a...

  17. 31 CFR 363.145 - May I delete a pending transaction involving a zero-percent certificate of indebtedness?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... involving a zero-percent certificate of indebtedness? 363.145 Section 363.145 Money and Finance: Treasury... PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.145 May I delete a pending transaction involving a...

  18. 31 CFR 363.145 - May I delete a pending transaction involving a zero-percent certificate of indebtedness?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... involving a zero-percent certificate of indebtedness? 363.145 Section 363.145 Money and Finance: Treasury... FISCAL SERVICE REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.145 May I delete a pending transaction involving a...

  19. 31 CFR 363.145 - May I delete a pending transaction involving a zero-percent certificate of indebtedness?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... involving a zero-percent certificate of indebtedness? 363.145 Section 363.145 Money and Finance: Treasury... PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Zero-Percent Certificate of Indebtedness Zero-Percent Certificate of Indebtedness § 363.145 May I delete a pending transaction involving a...

  20. 19 CFR 145.55 - Trademarks, trade names, and copyrights.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Trademarks, trade names, and copyrights. 145.55 Section 145.55 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Restricted and Prohibited Merchandise § 145.55 Trademarks, trade names, and copyrights....

  1. 19 CFR 145.55 - Trademarks, trade names, and copyrights.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Trademarks, trade names, and copyrights. 145.55 Section 145.55 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Restricted and Prohibited Merchandise § 145.55 Trademarks, trade names, and copyrights....

  2. 19 CFR 145.55 - Trademarks, trade names, and copyrights.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Trademarks, trade names, and copyrights. 145.55 Section 145.55 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Restricted and Prohibited Merchandise § 145.55 Trademarks, trade names, and copyrights....

  3. 19 CFR 145.55 - Trademarks, trade names, and copyrights.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Trademarks, trade names, and copyrights. 145.55 Section 145.55 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Restricted and Prohibited Merchandise § 145.55 Trademarks, trade names, and copyrights....

  4. Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

    PubMed Central

    Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

    2015-01-01

    Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy. PMID:25844599

  5. Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.

    PubMed

    Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

    2015-08-28

    Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy.

  6. 14 CFR 23.145 - Longitudinal control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Longitudinal control. 23.145 Section 23.145... Maneuverability § 23.145 Longitudinal control. (a) With the airplane as nearly as possible in trim at 1.3 VS1, it... application of single-handed control forces exceeding those specified in § 23.143(c). The trimming controls...

  7. 14 CFR 23.145 - Longitudinal control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Longitudinal control. 23.145 Section 23.145... Maneuverability § 23.145 Longitudinal control. (a) With the airplane as nearly as possible in trim at 1.3 VS1, it... application of single-handed control forces exceeding those specified in § 23.143(c). The trimming controls...

  8. 19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

  9. 19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

  10. 19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

  11. 19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

  12. 19 CFR 145.51 - Articles prohibited by section 305, Tariff Act of 1930.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Articles prohibited by section 305, Tariff Act of 1930. 145.51 Section 145.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...) Obscene matter; (2) Articles for causing unlawful abortion (see § 145.52 for the treatment of literature...

  13. 27 CFR 70.145 - Purchasers, holders of security interests, mechanic's lienors, and judgment lien creditors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... security interests, mechanic's lienors, and judgment lien creditors. 70.145 Section 70.145 Alcohol, Tobacco... Lien for Taxes § 70.145 Purchasers, holders of security interests, mechanic's lienors, and judgment... in § 70.143(a) of this part), mechanic's lienor (as defined in § 70.143(b) of this part), or judgment...

  14. 27 CFR 70.145 - Purchasers, holders of security interests, mechanic's lienors, and judgment lien creditors.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... security interests, mechanic's lienors, and judgment lien creditors. 70.145 Section 70.145 Alcohol, Tobacco... Lien for Taxes § 70.145 Purchasers, holders of security interests, mechanic's lienors, and judgment... in § 70.143(a) of this part), mechanic's lienor (as defined in § 70.143(b) of this part), or judgment...

  15. 27 CFR 70.145 - Purchasers, holders of security interests, mechanic's lienors, and judgment lien creditors.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... security interests, mechanic's lienors, and judgment lien creditors. 70.145 Section 70.145 Alcohol, Tobacco... Lien for Taxes § 70.145 Purchasers, holders of security interests, mechanic's lienors, and judgment... in § 70.143(a) of this part), mechanic's lienor (as defined in § 70.143(b) of this part), or judgment...

  16. 27 CFR 70.145 - Purchasers, holders of security interests, mechanic's lienors, and judgment lien creditors.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... security interests, mechanic's lienors, and judgment lien creditors. 70.145 Section 70.145 Alcohol, Tobacco... Lien for Taxes § 70.145 Purchasers, holders of security interests, mechanic's lienors, and judgment... in § 70.143(a) of this part), mechanic's lienor (as defined in § 70.143(b) of this part), or judgment...

  17. 27 CFR 70.145 - Purchasers, holders of security interests, mechanic's lienors, and judgment lien creditors.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... security interests, mechanic's lienors, and judgment lien creditors. 70.145 Section 70.145 Alcohol, Tobacco... Lien for Taxes § 70.145 Purchasers, holders of security interests, mechanic's lienors, and judgment... in § 70.143(a) of this part), mechanic's lienor (as defined in § 70.143(b) of this part), or judgment...

  18. 7 CFR 4287.145 - Default by borrower.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Default by borrower. 4287.145 Section 4287.145... Loans § 4287.145 Default by borrower. (a) The lender must notify the Agency when a borrower is 30 days past due on a payment or is otherwise in default of the Loan Agreement. Form FmHA 1980-44, “Guaranteed...

  19. 14 CFR 23.145 - Longitudinal control.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Longitudinal control. 23.145 Section 23.145... Maneuverability § 23.145 Longitudinal control. (a) With the airplane as nearly as possible in trim at 1.3 VS1, it... application of single-handed control forces exceeding those specified in § 23.143(c). The trimming controls...

  20. 14 CFR 23.145 - Longitudinal control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Longitudinal control. 23.145 Section 23.145... Maneuverability § 23.145 Longitudinal control. (a) With the airplane as nearly as possible in trim at 1.3 VS1, it... application of single-handed control forces exceeding those specified in § 23.143(c). The trimming controls...

  1. 19 CFR 145.23 - Time limits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Time limits. 145.23 Section 145.23 Customs Duties... (CONTINUED) MAIL IMPORTATIONS Administrative Review of Mail Entries § 145.23 Time limits. A mail entry may be... requests such amendment within the time limits prescribed therein (see §§ 173.4 and 173.5 of this chapter...

  2. 41 CFR 102-42.145 - When is public sale of a foreign gift or decoration authorized?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... foreign gift or decoration authorized? 102-42.145 Section 102-42.145 Public Contracts and Property... PROPERTY 42-UTILIZATION, DONATION, AND DISPOSAL OF FOREIGN GIFTS AND DECORATIONS Sale or Destruction of Foreign Gifts and Decorations § 102-42.145 When is public sale of a foreign gift or decoration authorized...

  3. 40 CFR 14.5 - Who may file a claim.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Who may file a claim. 14.5 Section 14.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL EMPLOYEE PERSONAL PROPERTY CLAIMS § 14.5 Who may file a claim. A claim may be filed by an employee or by his/her authorized agent or legal...

  4. 40 CFR 14.5 - Who may file a claim.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Who may file a claim. 14.5 Section 14.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL EMPLOYEE PERSONAL PROPERTY CLAIMS § 14.5 Who may file a claim. A claim may be filed by an employee or by his/her authorized agent or legal...

  5. 9 CFR 145.43 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Terminology and classification; flocks and products. 145.43 Section 145.43 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... Authorized Testing Agent must blood test up to 300 birds per flock, as described in § 145.14, if the Official...

  6. 9 CFR 145.43 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Terminology and classification; flocks and products. 145.43 Section 145.43 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... Authorized Testing Agent must blood test up to 300 birds per flock, as described in § 145.14, if the Official...

  7. 9 CFR 145.43 - Terminology and classification; flocks and products.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Terminology and classification; flocks and products. 145.43 Section 145.43 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... Authorized Testing Agent must blood test up to 300 birds per flock, as described in § 145.14, if the Official...

  8. An alternative approach in regulation of expression of a transgene by endogenous miR-145 in carcinoma and normal breast cell lines.

    PubMed

    Ghanbari Safari, Maryam; Baesi, Kazem; Hosseinkhani, Saman

    2017-03-01

    MicroRNAs are small noncoding RNAs that regulate gene expression by repressing translation of target cellular transcripts. Increasing evidences indicate that miRNAs have different expression profiles and play crucial roles in numerous cellular processes. Delivery and expression of transgenes for cancer therapy must be specific for tumors to avoid killing of healthy tissues. Many investigators have shown that transgene expression can be suppressed in normal cells using vectors that are responsive to microRNA regulation. To overcome this problem, miR-145 that exhibits downregulation in many types of cancer cells was chosen for posttranscriptional regulatory systems mediated by microRNAs. In this study, a psiCHECK-145T vector carrying four tandem copies of target sequences of miR-145 into 3'-UTR of the Renilla luciferase gene was constructed. Renilla luciferase activity from the psiCHECK-145T vector was 57% lower in MCF10A cells with high miR-145 expression as compared to a control condition. Additionally, overexpression of miR-145 in MCF-7 cells with low expression level of miR-145 showed more than 76% reduction in the Renilla luciferase activity from the psiCHECK-145T vector. Inclusion of miR-145 target sequences into the 3'-UTR of the Renilla luciferase gene is a feasible strategy for restricting transgene expression in a breast cancer cell line while sparing a breast normal cell line. © 2015 International Union of Biochemistry and Molecular Biology, Inc.

  9. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.

    PubMed

    Jiang, Lu-Yi; Jiang, Wei; Tian, Na; Xiong, Yan-Ni; Liu, Jie; Wei, Jian; Wu, Kai-Yue; Luo, Jie; Shi, Xiong-Jie; Song, Bao-Liang

    2018-03-16

    Cholesterol biosynthesis is tightly regulated in the cell. For example, high sterol concentrations can stimulate degradation of the rate-limiting cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, HMGCR). HMGCR is broken down by the endoplasmic reticulum membrane-associated protein complexes consisting of insulin-induced genes (Insigs) and the E3 ubiquitin ligase gp78. Here we found that HMGCR degradation is partially blunted in Chinese hamster ovary (CHO) cells lacking gp78 ( gp78 -KO). To identify other ubiquitin ligase(s) that may function together with gp78 in triggering HMGCR degradation, we performed a small-scale short hairpin RNA-based screening targeting endoplasmic reticulum-localized E3s. We found that knockdown of both ring finger protein 145 ( Rnf145 ) and gp78 genes abrogates sterol-induced degradation of HMGCR in CHO cells. We also observed that RNF145 interacts with Insig-1 and -2 proteins and ubiquitinates HMGCR. Moreover, the tetrapeptide sequence YLYF in the sterol-sensing domain and the Cys-537 residue in the RING finger domain were essential for RNF145 binding to Insigs and RNF145 E3 activity, respectively. Of note, amino acid substitutions in the YLYF or of Cys-537 completely abolished RNF145-mediated HMGCR degradation. In summary, our study reveals that RNF145, along with gp78, promotes HMGCR degradation in response to elevated sterol levels and identifies residues essential for RNF145 function. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. 22 CFR Appendix A to Part 145 - Clauses for Contracts and Small Purchases Awarded by Recipient

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Awarded by Recipient A Appendix A to Part 145 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS.... 145, App. A Appendix A to Part 145—Clauses for Contracts and Small Purchases Awarded by Recipient All contracts and small purchases, awarded by a recipient who is subject to this regulation, shall contain the...

  11. 22 CFR Appendix A to Part 145 - Clauses for Contracts and Small Purchases Awarded by Recipient

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Awarded by Recipient A Appendix A to Part 145 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS.... 145, App. A Appendix A to Part 145—Clauses for Contracts and Small Purchases Awarded by Recipient All contracts and small purchases, awarded by a recipient who is subject to this regulation, shall contain the...

  12. 22 CFR Appendix A to Part 145 - Clauses for Contracts and Small Purchases Awarded by Recipient

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Awarded by Recipient A Appendix A to Part 145 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS.... 145, App. A Appendix A to Part 145—Clauses for Contracts and Small Purchases Awarded by Recipient All contracts and small purchases, awarded by a recipient who is subject to this regulation, shall contain the...

  13. 19 CFR 145.34 - Personal and household effects and tools of trade.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Personal and household effects and tools of trade. 145.34 Section 145.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.34 Personal and household effects and tools of...

  14. 19 CFR 145.34 - Personal and household effects and tools of trade.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Personal and household effects and tools of trade. 145.34 Section 145.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.34 Personal and household effects and tools of...

  15. 19 CFR 145.34 - Personal and household effects and tools of trade.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Personal and household effects and tools of trade. 145.34 Section 145.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.34 Personal and household effects and tools of...

  16. 19 CFR 145.34 - Personal and household effects and tools of trade.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Personal and household effects and tools of trade. 145.34 Section 145.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.34 Personal and household effects and tools of...

  17. 41 CFR 102-2.145 - To what do pronouns refer when used in the FMR?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MANAGEMENT REGULATION SYSTEM Plain Language Regulatory Style § 102-2.145 To what do pronouns refer when used... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false To what do pronouns refer when used in the FMR? 102-2.145 Section 102-2.145 Public Contracts and Property Management Federal...

  18. 40 CFR 40.145-2 - Federal Water Pollution Control Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Federal Water Pollution Control Act. 40.145-2 Section 40.145-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.145-2 Federal Water Pollution Control Act. (a) No person in the United States shall on the...

  19. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and Strait...

  20. 46 CFR 7.145 - Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Strait of Juan de Fuca, Haro Strait and Strait of Georgia WA. 7.145 Section 7.145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.145 Strait of Juan de Fuca, Haro Strait and Strait...

  1. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.

    PubMed

    Zhang, Li; Rajbhandari, Prashant; Priest, Christina; Sandhu, Jaspreet; Wu, Xiaohui; Temel, Ryan; Castrillo, Antonio; de Aguiar Vallim, Thomas Q; Sallam, Tamer; Tontonoz, Peter

    2017-10-25

    Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activation and high-cholesterol diet feeding. Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis and reduces plasma cholesterol levels. Conversely, acute suppression of RNF145 via shRNA-mediated knockdown, or chronic inactivation of RNF145 by genetic deletion, potentiates the expression of cholesterol biosynthetic genes and increases cholesterol levels both in liver and plasma. Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. These findings define an additional mechanism linking hepatic sterol levels to the reciprocal actions of the SREBP-2 and LXR pathways.

  2. Elements of instruction in allied health: do faculty and students value the same things?

    PubMed

    Hoppes, Steve; Chesbro, Steven

    2003-01-01

    The purposes of this study were to determine the importance placed on 15 elements of instruction in allied health by students and faculty and to identify similarities and differences in students' and faculty's views. A total of 145 students and 55 faculty in the College of Allied Health at the University of Oklahoma participated in an on-line survey. Focus groups subsequently were conducted to discuss areas of agreement and disagreement between students and faculty. Four common elements were contained in the top-five list of both groups: (1) the teacher's ability to relate course material to clinical situations, (2) the teacher's communication skills, (3) the teacher's preparation and organization, and (4) the teacher's knowledge of the subject. Five of the 15 items were significantly different: (1) the teachers' friendliness and respect for students, (2) the teacher's ability to motivate students, (3) the teacher's ability to challenge students intellectually, (4) the teacher's encouragement of discussion, and (5) the teacher's ability to use a number of teaching techniques. Results of this study will further understanding between allied health faculty and students concerning similarities and differences in instructional values.

  3. Characteristics and impacts of trace elements in atmospheric deposition at a high-elevation site, southern China.

    PubMed

    Nie, Xiaoling; Wang, Yan; Li, Yaxin; Sun, Lei; Li, Tao; Yang, Minmin; Yang, Xueqiao; Wang, Wenxing

    2017-10-01

    To investigate the regional background trace element (TE) level in atmospheric deposition (dry and wet), TEs (Fe, Al, V, Cr, Mn, Ni, Cu, Zn, As, Se, Mo, Cd, Ba, and Pb) in 52 rainwater samples and 73 total suspended particles (TSP) samples collected in Mt. Lushan, Southern China, were analyzed using inductively coupled plasma-mass spectrometry (ICP-MS). The results showed that TEs in wet and dry deposition of the target area were significantly elevated compared within and outside China and the volume weight mean pH of rainwater was 4.43. The relative contributions of wet and dry depositions of TEs vary significantly among elements. The wet deposition fluxes of V, As, Cr, Se, Zn, and Cd exceeded considerably their dry deposition fluxes while dry deposition dominated the removal of pollution elements such as Mo, Cu, Ni, Mn, and Al. The summed dry deposition flux was four times higher than the summed wet deposition flux. Prediction results based on a simple accumulation model found that the content of seven toxic elements (Cr, Ni, Cu, Zn, As, Cd, and Pb) in soils could increase rapidly due to the impact of annual atmospheric deposition, and the increasing amounts of them reached 0.063, 0.012, 0.026, 0.459, 0.076, 0.004, and 0.145 mg kg -1 , respectively. In addition, the annual increasing rates ranged from 0.05% (Cr and Ni) to 2.08% (Cd). It was also predicted that atmospheric deposition induced the accumulation of Cr and Cd in surface soils. Cd was the critical element with the greatest potential ecological risk among all the elements in atmospheric deposition.

  4. 26 CFR 1.45D-1 - New markets tax credit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 1 2014-04-01 2013-04-01 true New markets tax credit. 1.45D-1 Section 1.45D-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.45D-1 New markets tax credit. (a) Current year credit. The current year genera...

  5. 26 CFR 1.45D-1 - New markets tax credit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 1 2013-04-01 2013-04-01 false New markets tax credit. 1.45D-1 Section 1.45D-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.45D-1 New markets tax credit. (a) Current year credit. The current year...

  6. 26 CFR 1.45D-1 - New markets tax credit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false New markets tax credit. 1.45D-1 Section 1.45D-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.45D-1 New markets tax credit. (a) Current year credit. The current year...

  7. 46 CFR 52.01-145 - Manufacturers' data report forms (modifies PG-112 and PG-113).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Manufacturers' data report forms (modifies PG-112 and PG-113). 52.01-145 Section 52.01-145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-145 Manufacturers' data report forms (modifies PG-112 and PG-113). The manufacturers'...

  8. 46 CFR 52.01-145 - Manufacturers' data report forms (modifies PG-112 and PG-113).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Manufacturers' data report forms (modifies PG-112 and PG-113). 52.01-145 Section 52.01-145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-145 Manufacturers' data report forms (modifies PG-112 and PG-113). The manufacturers'...

  9. 46 CFR 52.01-145 - Manufacturers' data report forms (modifies PG-112 and PG-113).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Manufacturers' data report forms (modifies PG-112 and PG-113). 52.01-145 Section 52.01-145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-145 Manufacturers' data report forms (modifies PG-112 and PG-113). The manufacturers'...

  10. 46 CFR 52.01-145 - Manufacturers' data report forms (modifies PG-112 and PG-113).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Manufacturers' data report forms (modifies PG-112 and PG-113). 52.01-145 Section 52.01-145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-145 Manufacturers' data report forms (modifies PG-112 and PG-113). The manufacturers'...

  11. 46 CFR 52.01-145 - Manufacturers' data report forms (modifies PG-112 and PG-113).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Manufacturers' data report forms (modifies PG-112 and PG-113). 52.01-145 Section 52.01-145 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING POWER BOILERS General Requirements § 52.01-145 Manufacturers' data report forms (modifies PG-112 and PG-113). The manufacturers'...

  12. 36 CFR 14.5 - Nature of interest granted; settlement on right-of-way; rights of ingress and egress.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Nature of interest granted; settlement on right-of-way; rights of ingress and egress. 14.5 Section 14.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.5 Nature...

  13. 36 CFR 14.5 - Nature of interest granted; settlement on right-of-way; rights of ingress and egress.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Nature of interest granted; settlement on right-of-way; rights of ingress and egress. 14.5 Section 14.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.5 Nature...

  14. 36 CFR 14.5 - Nature of interest granted; settlement on right-of-way; rights of ingress and egress.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Nature of interest granted; settlement on right-of-way; rights of ingress and egress. 14.5 Section 14.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.5 Nature...

  15. 36 CFR 14.5 - Nature of interest granted; settlement on right-of-way; rights of ingress and egress.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Nature of interest granted; settlement on right-of-way; rights of ingress and egress. 14.5 Section 14.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.5 Nature...

  16. 36 CFR 14.5 - Nature of interest granted; settlement on right-of-way; rights of ingress and egress.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Nature of interest granted; settlement on right-of-way; rights of ingress and egress. 14.5 Section 14.5 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Nature of Interest § 14.5 Nature...

  17. 26 CFR 145.4051-1 - Imposition of tax on heavy trucks and trailers sold at retail.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Imposition of tax on heavy trucks and trailers sold at retail. 145.4051-1 Section 145.4051-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... THE HIGHWAY REVENUE ACT OF 1982 (PUB. L. 97-424) § 145.4051-1 Imposition of tax on heavy trucks and...

  18. MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.

    PubMed

    Lee, Hae Kyung; Bier, Ariel; Cazacu, Simona; Finniss, Susan; Xiang, Cunli; Twito, Hodaya; Poisson, Laila M; Mikkelsen, Tom; Slavin, Shimon; Jacoby, Elad; Yalon, Michal; Toren, Amos; Rempel, Sandra A; Brodie, Chaya

    2013-01-01

    Glioblastomas (GBM), the most common and aggressive type of malignant glioma, are characterized by increased invasion into the surrounding brain tissues. Despite intensive therapeutic strategies, the median survival of GBM patients has remained dismal over the last decades. In this study we examined the expression of miR-145 in glial tumors and its function in glioma cells. Using TCGA analysis and real-time PCR we found that the expression of miR-145/143 cluster was downregulated in astrocytic tumors compared to normal brain specimens and in glioma cells and glioma stem cells (GSCs) compared to normal astrocytes and neural stem cells. Moreover, the low expression of both miR-145 and miR-143 in GBM was correlated with poor patient prognosis. Transfection of glioma cells with miR-145 mimic or transduction with a lentivirus vector expressing pre-miR 145 significantly decreased the migration and invasion of glioma cells. We identified connective tissue growth factor (CTGF) as a novel target of miR-145 in glioma cells; transfection of the cells with this miRNA decreased the expression of CTGF as determined by Western blot analysis and the expression of its 3'-UTR fused to luciferase. Overexpression of a CTGF plasmid lacking the 3'-UTR and administration of recombinant CTGF protein abrogated the inhibitory effect of miR-145 on glioma cell migration. Similarly, we found that silencing of CTGF decreased the migration of glioma cells. CTGF silencing also decreased the expression of SPARC, phospho-FAK and FAK and overexpression of SPARC abrogated the inhibitory effect of CTGF silencing on cell migration. These results demonstrate that miR-145 is downregulated in glial tumors and its low expression in GBM predicts poor patient prognosis. In addition miR-145 regulates glioma cell migration by targeting CTGF which downregulates SPARC expression. Therefore, miR-145 is an attractive therapeutic target for anti-invasive treatment of astrocytic tumors.

  19. Scale-Up of Lubricant Mixing Process by Using V-Type Blender Based on Discrete Element Method.

    PubMed

    Horibe, Masashi; Sonoda, Ryoichi; Watano, Satoru

    2018-01-01

    A method for scale-up of a lubricant mixing process in a V-type blender was proposed. Magnesium stearate was used for the lubricant, and the lubricant mixing experiment was conducted using three scales of V-type blenders (1.45, 21 and 130 L) under the same fill level and Froude (Fr) number. However, the properties of lubricated mixtures and tablets could not correspond with the mixing time or the total revolution number. To find the optimum scale-up factor, discrete element method (DEM) simulations of three scales of V-type blender mixing were conducted, and the total travel distance of particles under the different scales was calculated. The properties of the lubricated mixture and tablets obtained from the scale-up experiment were well correlated with the mixing time determined by the total travel distance. It was found that a scale-up simulation based on the travel distance of particles is valid for the lubricant mixing scale-up processes.

  20. Zone-boundary optimization for direct laser writing of continuous-relief diffractive optical elements.

    PubMed

    Korolkov, Victor P; Nasyrov, Ruslan K; Shimansky, Ruslan V

    2006-01-01

    Enhancing the diffraction efficiency of continuous-relief diffractive optical elements fabricated by direct laser writing is discussed. A new method of zone-boundary optimization is proposed to correct exposure data only in narrow areas along the boundaries of diffractive zones. The optimization decreases the loss of diffraction efficiency related to convolution of a desired phase profile with a writing-beam intensity distribution. A simplified stepped transition function that describes optimized exposure data near zone boundaries can be made universal for a wide range of zone periods. The approach permits a similar increase in the diffraction efficiency as an individual-pixel optimization but with fewer computation efforts. Computer simulations demonstrated that the zone-boundary optimization for a 6 microm period grating increases the efficiency by 7% and 14.5% for 0.6 microm and 1.65 microm writing-spot diameters, respectively. The diffraction efficiency of as much as 65%-90% for 4-10 microm zone periods was obtained experimentally with this method.

  1. Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mu, Yang, E-mail: muyang@nwsuaf.edu.cn; Experimental Station of Veterinary Pharmacology and Veterinary Biotechnology, Ministry of Agriculture of the People's Republic of China, No. 22 Xinong Road, Yangling, Shaanxi 712100; Li, Liangliang, E-mail: lifeiyang2007@126.com

    Cell apoptosis is common after infection with porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV GP5 has been reported to induce cell apoptosis. To further understand the role of GP5 in PRRSV induced cell apoptosis, we established Marc-145 cell lines stably expressing full-length GP5, GP5{sup Δ84-96} (aa 84-96 deletion), and GP5{sup Δ97-119} (aa 97-119 deletion). Cell proliferation, cell cycle progression, cell apoptosis and virus replication in these cell lines were evaluated. Neither truncated nor full-length GP5 induced cell apoptosis in Marc-145 cells. However, GP5{sup Δ97-119}, but not full-length or GP5{sup Δ84-96}, induced a cell cycle arrest at the G2/M phasemore » resulting in a reduction in the growth of Marc-145 cells. Additionally, GP5{sup Δ84-96} inhibited the replication of PRRSV in Marc-145 cells through induction of IFN-β. These findings suggest that PRRSV GP5 is not responsible for inducing cell apoptosis in Marc-145 cells under these experimental conditions; however it has other important roles in virus/host cell biology. - Highlights: • Marc-145 cell lines stable expression PRRSV GP5 or truncated GP5 were constructed. • GP5{sup Δ97-119} expression in Marc-145 cell induced cell cycle arrest at G2/M phase. • Expression of GP5 and truncated GP5 could not induce Marc-145 cells apoptosis. • PRRSV replication in Marc-145-GP5{sup Δ84-96} was significantly inhibited.« less

  2. Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma

    PubMed Central

    Wang, Ji Yu; Fang, Meng; Boye, Alex; Wu, Chao; Wu, Jia Jun; Ma, Ying; Hou, Shu; Kan, Yue; Yang, Yan

    2017-01-01

    MicroRNAs 21 and 145 exhibit inverse expression in Hepatocellular carcinoma (HCC), but how they relate to Smad3 C-terminal and Link region phosphorylation (pSmad3C and pSmad3L) downstream of TGF-β/MAPK signaling, remains inconclusive. Our results suggest microRNA-145 targets Smad3 in HepG2 cells. Decreased tumor volume and increased apoptosis were produced in both microRNA-21 antagomir and microRNA-145 agomir groups compared to controls. Inhibition of TβRI and MAPK (ERK, JNK, and p38) activation respectively produced decreased microRNA-21 but increased microRNA-145 expression. Correspondingly, the expression level of pSmad3C obviously increased while pSmad3L decreased in microRNA-145 agomir-group and the expression of pSmad3C/3L were not markedly changed but pERK, pJNK, pp38 decreased in microRNA-21 antagomir-group compared to controls. On the other hand, microRNA-145 and 21 increased respectively in xenografts of HepG2 cells transfected with Smad3 EPSM and 3S-A plasmid, and this correlated with the overexpression of pSmad3C and pSmad3L respectively compared to control. To conclude, microRNA-21 promotes tumor progression in a MAPK-dependent manner while microRNA-145 suppresses it via domain-specific phosphorylation of Smad3 in HCC. Meanwhile, increased pSmad3C/3L lead to the up-regulation of microRNA-145/21 respectively. The interaction between pSmad3C/3L and microRNA-145/21 regulates HCC progression and the switch of pSmad3C/3L may serve as an important target for HCC therapy. PMID:29156696

  3. Specific receptor for inositol-1,4,5-trisphosphate in permeabilized rabbit neutrophils

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bradford, P.G.; Spat, A.; Rubin, R.P.

    1986-03-05

    Neutrophil chemotaxis and degranulation are resultant, in part, from the mobilization of intracellular calcium by inositol-1,4,5-trisphosphate ((1,4,5)IP/sub 3/), one of the products of chemoattractant-stimulated phospholipase C activity. High specific activity (ca. 40 Ci/mmol) (/sup 32/P)(1,4,5)IP/sub 3/ was prepared from (..gamma..-/sup 32/P)ATP-labeled human erythrocyte ghosts and was used in binding assays with saponin-permeabilized rabbit peritoneal neutrophils. At 4/sup 0/C and in the presence of inhibitors of the IP/sub 3/ 5-phosphomonoesterase, (/sup 32/P)(1,4,5)IP/sub 3/ rapidly associated with a specific binding component which saturated within 60s. Nonspecific binding, taken as the residual binding in the presence of 10 ..mu..M (1,4,5)IP/sub 3/, was 15%more » of the total. No specific binding was detected using intact cells. The specific binding to permeable cells was reversible (t/sup 1/2/ approx. 60s) and could be inhibited in a dose-dependent manner by (1,4,5)IP/sub 3/ (EC/sub 50/ = 30 nM) and by other calcium mobilizing inositol phosphates ((2,4,5)IP/sub 3/) but not by inactive analogs ((1,4)IP/sub 2/, (4,5)IP/sub 2/, (1)IP). The dose-responses of (1,4,5)IP/sub 3/ and (2,4,5)IP/sub 3/ in inhibiting (/sup 32/P)(1,4,5)IP/sub 3/ specific binding correlated well with their abilities to release Ca/sup 2 +/ from nonmitochondrial vesicular stores in the same preparation of cells, suggesting that the authors have identified the physiological receptor for (1,4,5)IP/sub 3/.« less

  4. miR-145 targets the SOX11 3’UTR to suppress endometrial cancer growth

    PubMed Central

    Chang, Lei; Yuan, Zhongfu; Shi, Huirong; Bian, Yangyang; Guo, Ruixia

    2017-01-01

    To explore the functions of SOX (Sex determining Region Y-related HMG-box) family genes in endometrial cancer (EC) and determine the influence of miR-145/SOX11 on EC cell functions. The relationship between miR-145 and SOX11 was confirmed using TargetScan, miRNA databases and dual-luciferase reporter gene assays. The expression of SOX11 mRNA in tissue specimens was examined using RT-qPCR, while SOX11 protein expression in tissues and cell lines were detected through immunohistochemistry (IHC) and western blotting. After transfection using Lipofectamine 2000, the proliferation, migration, invasion and apoptosis of ECC-1 and HEC-1-A cells were assessed through colony formation, transwell and flow cytometry assays. The correlation of SOX11 expression with the prognosis outcomes of patients was analyzed using Kaplan-Meier analysis and the log-rank test. SOX11 showed high expression in EC, which is negatively correlated with a poor prognostic outcome of EC patients. The expression of miR-145 was lower in EC tissues than in adjacent tissues. MiR-145 significantly reduced the expression of SOX11. In ECC-1 cells, miR-145 suppressed the propagation, migration, and invasion of cells and promoted cell apoptosis. MiR-145 also inhibited the proliferation, migration, and invasion of HEC-1-A cells and facilitated cell apoptosis by inhibiting SOX11. MiR-145 targeted site 3 (3615) of the SOX11 3’UTR to affect the expression of SOX11. MiR-145 and its target gene SOX11 could serve as diagnostic markers for EC. MiR-145 targets the SOX11 3’UTR to inhibit its expression and suppress the propagation and metastasis of EC cells. PMID:29218252

  5. Improved austenitic stainless steel for high temperature applications. [Improved stress-rupture properties

    DOEpatents

    Not Available

    This invention describes a composition for an austenitic stainless steel which has been found to exhibit improved high temperature stress rupture properties. The composition of this alloy is about (in wt. %): 12.5 to 14.5 Cr; 14.5 to 16.5 Ni; 1.5 to 2.5 Mo; 1.5 to 2.5 Mn; 0.1 to 0.4 Ti; 0.02 to 0.08 C; 0.5 to 1.0 Si; 0.01 maximum, N; 0.02 to 0.08 P; 0.002 to 0.008 B; 0.004-0.010 S; 0.02-0.05 Nb; .01-.05 V; 0.005-0.02 Ta; 0.02-0.05 Al; 0.01-0.04 Cu; 0.02-0.05 Co; .03 maximum, As; 0.01 maximum, 0; 0.01 maximum, Zr; and with the balance of the alloy being essentially iron. The carbon content of the alloy is adjusted such that wt. % Ti/(wt. % C+wt. % N) is between 4 and 6, and most preferably about 5. In addition the sum of the wt. % P + wt. % B + wt. % S is at least 0.03 wt. %. This alloy is believed to be particularly well suited for use as fast breeder reactor fuel element cladding.

  6. Visible light photocatalytic activities of template free porous graphitic carbon nitride-BiOBr composite catalysts towards the mineralization of reactive dyes

    NASA Astrophysics Data System (ADS)

    Kanagaraj, Thamaraiselvi; Thiripuranthagan, Sivakumar; Paskalis, Sahaya Murphin Kumar; Abe, Hideki

    2017-12-01

    Template free porous g-C3N4 (pGCN) and flower like bismuth oxybromide catalysts were synthesized by poly condensation and precipitation methods respectively. Various weight percentages of porous GCN-BiOBr composite catalysts (x% pGCN-BiOBr where x = 5, 10, 30, 50 & 70 wt% of pGCN) were synthesized by impregnation method. All the synthesized catalysts were characterized by X-Ray diffractometer, Fourier transform infrared spectrophotometer, BET surface area analyzer, UV Visible diffuse reflectance spectrophotometer, X-Ray photoelectron spectrophotometer, SEM with Energy dispersive X-ray analyzer (SEM/EDAX) and elemental mapping, Transmission electron microscope, Photoluminescence spectrophotometer and Electrochemical impedance. Photocatalytic degradation of all the synthesized catalysts were tested towards the harmful reactive dyes such as reactive blue 198 (RB 198), reactive black 5 (RB 5) and reactive yellow 145 (RY 145) in presence of visible irradiation. Among the catalysts 30% pGCN-BiOBr resulted in the highest photocatalytic activity towards the degradation of all the three dyes in presence of UV, visible and solar irradiations. Kinetics studies on the photocatalytic mineralization of dyes indicated that it followed pseudo first order. HPLC, TOC and COD studies confirm that the dyes are mineralized into CO2, water and mineral salts.

  7. Far Sidelobes Measurement of the Atacama Cosmology Telescope

    NASA Technical Reports Server (NTRS)

    Duenner, Rolando; Gallardo, Patricio; Wollack, Ed; Henriquez, Fernando; Jerez-Hanckes, Carlos

    2012-01-01

    The Atacama Cosmology Telescope (ACT) is a 6m telescope designed to map the Cosmic Microwave Background (CMB) simultaneously at 145GHz, 220 GHz and 280 GHz. Its off-axis Gregorian design is intended to minimize and control the off-axis sidelobe response, which is critical for scientific purposes. The expected sidelobe level for this kind of design is less than -50 dB and can be challenging to measure. Here we present a measurement of the 145 GHz far sidelobes of ACT done on the near-field of the telescope. We used a 1 mW microwave source placed 13 meters away from the telescope and a chopper wheel to produce a varying signal that could be detected by the camera for different orientations of the telescope. The source feed was designed to produce a wide beam profile. Given that the coupling is expected to be dominated by diffraction over the telescope shielding structure, when combined with a measurements of the main beam far field response, these measurement can be used to validate elements of optical design and constrain the level of spurious coupling at large angles. Our results show that the diffractive coupling beyond the ground screen is consistently below -75 dB, satisfying the design expectations.

  8. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small high...

  9. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small high...

  10. 25 CFR 39.145 - Can a school receive both a small school adjustment and a small high school adjustment?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... small high school adjustment? 39.145 Section 39.145 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Adjustment § 39.145 Can a school receive both a small school adjustment and a small high school adjustment? A school that meets the criteria in § 39.140 can receive both a small school adjustment and a small high...

  11. microRNA-145 regulates the RLR signaling pathway in miiuy croaker after poly(I:C) stimulation via targeting MDA5.

    PubMed

    Han, Jingjing; Sun, Yuena; Song, Weihua; Xu, Tianjun

    2017-03-01

    MicroRNAs (miRNAs) are endogenous small non-coding RNAs that participate in diverse biological processes via degrading the target mRNAs or repressing translation. In this study, the regulation of miRNA to the RLR (RIG-I-like receptor) signaling pathway by degrading the target mRNAs was researched in miiuy croaker. MDA5, a microRNA-145-5p (miR-145-5p) putative target gene, was predicted by bioinformatics, and the target sites from the 3'untranslated region of MDA5 transcripts were confirmed using luciferase reporter assays. Pre-miR-145 was more effective in inhibiting MDA5 than miR-145-5p mimic, and the effect was dose- and time-dependent. The expression patterns of miR-145-5p and MDA5 were analyzed in liver and kidney from miiuy croaker. Results implied that miR-145-5p may function via degrading the MDA5 mRNAs, thereby regulating the RLR signaling pathway. Studies on miR-145-5p will enrich knowledge of its functions in immune response regulation in fish, as well as offer a basis for regulatory networks that are composed of numerous miRNAs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Minor elements incorporation control by ionic radius and growth rate on a stalagmite from the Chauvet Cave (SE-France)

    NASA Astrophysics Data System (ADS)

    Bourdin, C.; Douville, E.; Genty, D.

    2009-12-01

    A multi-elemental study focusing on earth-alkalis (Mg, Ca, Sr and Ba), uranium and rare-earth elements (REE) in the calcite of a stalagmite from the Chauvet Cave (SE of France) has been achieved by ICP-MS. The Chau-stm6 stalagmite which grew from 33 to 11.5 ky had already been dated and the published d13C and d18O profile is used as a paleoclimatic benchmark. Ba and Sr profiles show an abrupt concentration increase at the beginning of the last deglaciation whereas U and Mg feature a decreasing trend. REY (REE+yttrium) concentrations decrease markedly during early deglaciation (between 15 and 14.5 ky). The transition corresponds to a change from a slow to a fast growth rate. These variations can be explained by the crystallographic control of ionic radii of the minor elements: incorporation of small ions compared to Ca such as U, Mg, heavy REE are favoured during slow growth period (i.e. glacial) whereas large ions such as Ba, Sr and light REE are preferentially precipitated during fast growth period (i.e. Bolling-Allerod). This crystallographic effect seems to be dominant here because the soil above the cave is sparse. And may not have played a major role on the opposite to the water-limestone interaction.

  13. [Effects of overexpression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells and its mechanism].

    PubMed

    Zhou, P; Ma, L; Zhou, J; Xu, J J; Liu, F; Guo, F

    2017-05-23

    Objective: To explore the effect and mechanism of over-expression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells. Methods: DU145 cells were transfected with miR-17-92 gene expression plasmid and clones with stable ectopic miR-17-92 overexpression were established. The cell viabilities of DU145-17-92 and DU145-control cells were monitored by xCELLigence system. Cell proliferation and apoptosis were analyzed by Ki-67 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Cell cycle was detected by flow cytometry. Expression levels of proteins involved in apoptosis and Akt pathway were determined by western blotting. Results: xCELLigence RTCA array data showed that the growth rate of DU145-17-92 cells was significantly higher than that of DU145-control cells after 24 h of seeding ( P <0.01). The Ki-67-positive rates of the DU145-control group at 24, 48 and 72 hours were (56.57±1.68)%, (85.48±0.26)% and (90.85±2.08)%, respectively. While the Ki-67 positive rates of the DU145-17-92 group at the desired time points were (73.64±0.68)%, (93.43±1.23)% and (97.36±0.86)%, respectively, with a statistically significant difference at 24 hours ( P <0.01). The percentages of apoptotic cells of the DU145-control group at 24, 48 and 72 hours were (6.76±0.09)%, (14.51±0.86)% and (20.73±1.64)%, respectively, while the apoptotic percentages of the DU145-17-92 group were (1.86±0.15)%, (7.90±0.40)% and (4.92±0.48)%, respectively. The percentages of apoptotic cells of the DU145-control group at different time were significantly higher than those of DU145-17-92 group ( P <0.01 for all). The result of western blotting showed that the protein expression levels of Bcl-2 interacting mediator of cell death (BIM) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in DU145-control cells were 0.83±0.00 and 0.91±0.00, respectively, significantly higher than 0.16±0.00 and 0.13±0.00 of DU145-17-92 cells (both P <0.01). Overexpression of miR17-92 induced the phosphorylation of protein kinase B (Akt) at Ser473 while no appreciable effect on the phosphorylation of Akt at Thr308. The phosphorylated level of extracellular regulated protein kinases (ERK) in DU145-control cells was 0.21±0.01, significantly lower than 0.72±0.01 of DU145-17-92 cells ( P <0.01). Conclusions: Overexpression of miR-17-92 gene plays a pivotal role in growth, proliferation, apoptosis and cell cycle of DU145 cells through down-regulation of apoptotic protein BIM and tumor suppressor PTEN and activation of Akt and ERK signaling pathway.

  14. 45 CFR 233.145 - Expiration of medical assistance programs under titles I, IV-A, X, XIV and XVI of the Social...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... titles I, IV-A, X, XIV and XVI of the Social Security Act. 233.145 Section 233.145 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.145 Expiration of medical assistance programs under titles I, IV-A, X..., enacted July 30, 1965, no payment may be made to any State under title I, IV-A, X, XIV or XVI of the...

  15. 45 CFR 233.145 - Expiration of medical assistance programs under titles I, IV-A, X, XIV and XVI of the Social...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... titles I, IV-A, X, XIV and XVI of the Social Security Act. 233.145 Section 233.145 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.145 Expiration of medical assistance programs under titles I, IV-A, X..., enacted July 30, 1965, no payment may be made to any State under title I, IV-A, X, XIV or XVI of the...

  16. 45 CFR 233.145 - Expiration of medical assistance programs under titles I, IV-A, X, XIV and XVI of the Social...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... titles I, IV-A, X, XIV and XVI of the Social Security Act. 233.145 Section 233.145 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.145 Expiration of medical assistance programs under titles I, IV-A, X..., enacted July 30, 1965, no payment may be made to any State under title I, IV-A, X, XIV or XVI of the...

  17. 45 CFR 233.145 - Expiration of medical assistance programs under titles I, IV-A, X, XIV and XVI of the Social...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... titles I, IV-A, X, XIV and XVI of the Social Security Act. 233.145 Section 233.145 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.145 Expiration of medical assistance programs under titles I, IV-A, X..., enacted July 30, 1965, no payment may be made to any State under title I, IV-A, X, XIV or XVI of the...

  18. 45 CFR 233.145 - Expiration of medical assistance programs under titles I, IV-A, X, XIV and XVI of the Social...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... titles I, IV-A, X, XIV and XVI of the Social Security Act. 233.145 Section 233.145 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.145 Expiration of medical assistance programs under titles I, IV-A, X..., enacted July 30, 1965, no payment may be made to any State under title I, IV-A, X, XIV or XVI of the...

  19. Defining the minimal structural requirements for partial agonism at the type I myo-inositol 1,4,5-trisphosphate receptor.

    PubMed

    Wilcox, R A; Fauq, A; Kozikowski, A P; Nahorski, S R

    1997-02-03

    The novel synthetic analogues D-3-fluoro-myo-inositol 1,5-bisphosphate-4-phosphorothioate, [3F-Ins(1,5)P2-4PS], D-3-fluoro-myo-inositol 1,4-bisphosphate-5-phosphorothioate [3F-Ins(1,4)P2-5PS], and D-3-fluoro-myo-inositol 1-phosphate-4,5-bisphosphorothioate [3F-Ins(1)P-(4,5)PS2] were utilised to define the structure-activity relationships which could produce partial agonism at the Ca2+ mobilising myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] receptor. Based on prior structure-activity data we hypothesised that the minimal structural requirements for lns(1,4,5)P3 receptor partial agonism, were phosphorothioate substitution of the crucial vicinal 4,5-bisphosphate pair accompanied by another structural perturbation, such fluorination of 3-position of the myo-inositol ring. All the analogues fully displaced [3H]Ins(1,4,5)P3 from a single Ins(1,4,5)P3 binding site in pig cerebellar membranes [3F-Ins(1,5)P2-4PS (1C50 = 26 nM), 3F-Ins(1,4)P2-5PS (IC50 = 80 nM) and 3F-Ins(1)P-(4,5)PS2 (IC50 = 109 nM) cf. Ins(1,4,5)P3 (IC50 = 11 nM)]. In contrast, 3F-Ins(1,5)P2-4PS (IC50 = 424 nM) and 3F-Ins(1,4)P2-5PS (IC50 = 3579 nM) were weak full agonists at the Ca2+ mobilising Ins(1,4,5)P3 receptor of permeabilised SH-SY5Y neuroblastoma cells, being respectively 4- and 36-fold less potent than Ins(1,4,5)P3 (EC50 = 99 nM). While 3F-Ins(1)P-(4,5)PS2 (EC50 = 11345 nM) was a partial agonist releasing only 64.3 +/- 1.9% of the Ins(1,4,5)P3-sensitive intracellular Ca2+ pools. 3F-Ins(1)P-(4,5)PS2 was unique among the Ins(1,4,5)P3 receptor partial agonists so far identified in having a relatively high affinity for the Ins(1,4,5)P3 binding site, accompanied by a significant loss of intrinsic activity for Ca2+ mobilisation. This improved affinity was probably due to the retention of the 1-position phosphate, which enhances interaction with the Ins-(1,4,5)P3 receptor. 3F-Ins(1)P-(4,5)PS2 may be an important lead compound for the development of efficient Ins(1,4,5)P3 receptor antagonists.

  20. Omega Design and FEA Based Coriolis Mass Flow Sensor (CMFS) Analysis Using Titanium Material

    NASA Astrophysics Data System (ADS)

    Patil, Pravin P.; Kumar, Ashwani; Ahmad, Faraz

    2018-02-01

    The main highlight of this research work is evaluation of resonant frequency for titanium omega type coriolis mass flow sensor. Coriolis mass flow sensor is used for measuring direct mass flow in pipe useful for various industrial applications. It works on the principle of Coriolis effect. Finite Element Analysis (FEA) simulation of omega flow sensor was performed using Ansys 14.5 and Solid Edge, Pro-E was used for modelling of omega tube. Titanium was selected as omega tube material. Experimental setup was prepared for omega tube coriolis flow sensor for performing different test. Experimental setup was used for investigation of different parameters effect on CMFS and validation of simulation results.

  1. Variable-camber systems integration and operational performance of the AFTI/F-111 mission adaptive wing

    NASA Technical Reports Server (NTRS)

    Smith, John W.; Lock, Wilton P.; Payne, Gordon A.

    1992-01-01

    The advanced fighter technology integration, the AFTI/F-111 aircraft, is a preproduction F-111A testbed research airplane that was fitted with a smooth variable-camber mission adaptive wing. The camber was positioned and controlled by flexing the upper skins through rotary actuators and linkages driven by power drive units. The wing camber and control system are described. The measured servoactuator frequency responses are presented along with analytical predictions derived from the integrated characteristics of the control elements. A mission adaptive wing system chronology is used to illustrate and assess the reliability and dependability of the servoactuator system during 1524 hours of ground tests and 145 hours of flight testing.

  2. Mountain wetlands: efficient uranium filters - potential impacts

    USGS Publications Warehouse

    Owen, D.E.; Otton, J.K.

    1995-01-01

    Sediments in 67 of 145 Colorado wetlands sampled by the US Geological Survey contain moderate (20 ppm) or greater concentrations of uranium (some as high as 3000 ppm) based on dry weight. The proposed maximum contaminant level (MCL) for uranium in drinking water is 20 ??g/l or 20 ppb. By comparison, sediments in many of these wetlands contain 3 to 5 orders of magnitude more uranium than the proposed MCL. Wetlands near the workings of old mines may be trapping any number of additional metals/elements including Cu, Pb, Zn, As and Ag. Anthropogenic disturbances and natural changes may release uranium and other loosely bound metals presently contained in wetland sediments. -from Authors

  3. Deletion of the miR-143/145 Cluster Leads to Hydronephrosis in Mice

    PubMed Central

    Medrano, Silvia; Sequeira-Lopez, Maria Luisa S.; Gomez, R. Ariel

    2015-01-01

    Obstructive nephropathy, the leading cause of kidney failure in children, can be anatomic or functional. The underlying causes of functional hydronephrosis are not well understood. miRNAs, which are small noncoding RNAs, regulate gene expression at the post-transcriptional level. We found that miR-145-5p, a member of the miR-143/145 cluster that is highly expressed in smooth muscle cells of the renal vasculature, was present in the pelvicalyceal system and the ureter. To evaluate whether the miR-143/145 cluster is involved in urinary tract function we performed morphologic, functional, and gene expression studies in mice carrying a whole-body deletion of miR-143/145. miR-143/145–deficient mice developed hydronephrosis, characterized by severe papillary atrophy and dilatation of the pelvicalyceal system without obvious physical obstruction. Moreover, mutant mice showed abnormal ureteral peristalsis. The number of ureter contractions was significantly higher in miR-143/145–deficient mice. Peristalsis was replaced by incomplete, short, and more frequent contractions that failed to completely propagate in a proximal-distal direction. Microarray analysis showed 108 differentially expressed genes in ureters of miR-143/145–deficient mice. Ninety genes were up-regulated and 18 genes were down-regulated, including genes with potential regulatory roles in smooth muscle contraction and extracellular matrix-receptor interaction. We show that miR-143/145 are important for the normal peristalsis of the ureter and report an association between the expression of these miRNAs and hydronephrosis. PMID:25307343

  4. 17 CFR Appendix C to Part 145 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false [Reserved] C Appendix C to Part 145 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION COMMISSION RECORDS AND INFORMATION Appendix C to Part 145 [Reserved] ...

  5. 21 CFR 1271.145 - Prevention of the introduction, transmission, or spread of communicable diseases.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... spread of communicable diseases. 1271.145 Section 1271.145 Food and Drugs FOOD AND DRUG ADMINISTRATION... diseases. You must recover, process, store, label, package, and distribute HCT/Ps, and screen and test cell... diseases. ...

  6. 21 CFR 1271.145 - Prevention of the introduction, transmission, or spread of communicable diseases.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... spread of communicable diseases. 1271.145 Section 1271.145 Food and Drugs FOOD AND DRUG ADMINISTRATION... diseases. You must recover, process, store, label, package, and distribute HCT/Ps, and screen and test cell... diseases. ...

  7. 14 CFR 145.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Applicability. 145.1 Section 145.1 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND... follow related to its performance of maintenance, preventive maintenance, or alterations of an aircraft...

  8. 21 CFR 1271.145 - Prevention of the introduction, transmission, or spread of communicable diseases.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... spread of communicable diseases. 1271.145 Section 1271.145 Food and Drugs FOOD AND DRUG ADMINISTRATION... diseases. You must recover, process, store, label, package, and distribute HCT/Ps, and screen and test cell... diseases. ...

  9. 21 CFR 1271.145 - Prevention of the introduction, transmission, or spread of communicable diseases.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... spread of communicable diseases. 1271.145 Section 1271.145 Food and Drugs FOOD AND DRUG ADMINISTRATION... diseases. You must recover, process, store, label, package, and distribute HCT/Ps, and screen and test cell... diseases. ...

  10. 21 CFR 1271.145 - Prevention of the introduction, transmission, or spread of communicable diseases.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... spread of communicable diseases. 1271.145 Section 1271.145 Food and Drugs FOOD AND DRUG ADMINISTRATION... diseases. You must recover, process, store, label, package, and distribute HCT/Ps, and screen and test cell... diseases. ...

  11. 40 CFR 35.145 - Maximum federal share.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 35.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.145 Maximum federal share. (a) The Regional Administrator may provide air pollution control agencies, as...

  12. 40 CFR 35.145 - Maximum federal share.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 35.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.145 Maximum federal share. (a) The Regional Administrator may provide air pollution control agencies, as...

  13. 42 CFR 480.145 - Beneficiary authorization of use of confidential information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... information. 480.145 Section 480.145 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION INFORMATION Utilization and Quality Control Quality...

  14. 42 CFR 480.145 - Beneficiary authorization of use of confidential information.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... information. 480.145 Section 480.145 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS ACQUISITION, PROTECTION, AND DISCLOSURE OF QUALITY IMPROVEMENT ORGANIZATION INFORMATION Utilization and Quality Control Quality...

  15. 40 CFR 35.145 - Maximum federal share.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 35.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.145 Maximum federal share. (a) The Regional Administrator may provide air pollution control agencies, as...

  16. 14 CFR 145.107 - Satellite repair stations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Satellite repair stations. 145.107 Section 145.107 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Housing, Facilities, Equipment, Materials, and...

  17. 14 CFR 145.107 - Satellite repair stations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Satellite repair stations. 145.107 Section 145.107 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Housing, Facilities, Equipment, Materials, and...

  18. 14 CFR 145.107 - Satellite repair stations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Satellite repair stations. 145.107 Section 145.107 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Housing, Facilities, Equipment, Materials, and...

  19. 14 CFR 145.107 - Satellite repair stations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Satellite repair stations. 145.107 Section 145.107 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Housing, Facilities, Equipment, Materials, and...

  20. 14 CFR 145.107 - Satellite repair stations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Satellite repair stations. 145.107 Section 145.107 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Housing, Facilities, Equipment, Materials, and...

  1. TGFβ Triggers miR-143/145 Transfer From Smooth Muscle Cells to Endothelial Cells, Thereby Modulating Vessel Stabilization.

    PubMed

    Climent, Montserrat; Quintavalle, Manuela; Miragoli, Michele; Chen, Ju; Condorelli, Gianluigi; Elia, Leonardo

    2015-05-22

    The miR-143/145 cluster is highly expressed in smooth muscle cells (SMCs), where it regulates phenotypic switch and vascular homeostasis. Whether it plays a role in neighboring endothelial cells (ECs) is still unknown. To determine whether SMCs control EC functions through passage of miR-143 and miR-145. We used cocultures of SMCs and ECs under different conditions, as well as intact vessels to assess the transfer of miR-143 and miR-145 from one cell type to another. Imaging of cocultured cells transduced with fluorescent miRNAs suggested that miRNA transfer involves membrane protrusions known as tunneling nanotubes. Furthermore, we show that miRNA passage is modulated by the transforming growth factor (TGF) β pathway because both a specific transforming growth factor-β (TGFβ) inhibitor (SB431542) and an shRNA against TGFβRII suppressed the passage of miR-143/145 from SMCs to ECs. Moreover, miR-143 and miR-145 modulated angiogenesis by reducing the proliferation index of ECs and their capacity to form vessel-like structures when cultured on matrigel. We also identified hexokinase II (HKII) and integrin β 8 (ITGβ8)-2 genes essential for the angiogenic potential of ECs-as targets of miR-143 and miR-145, respectively. The inhibition of these genes modulated EC phenotype, similarly to miR-143 and miR-145 overexpression in ECs. These findings were confirmed by ex vivo and in vivo approaches, in which it was shown that TGFβ and vessel stress, respectively, triggered miR-143/145 transfer from SMCs to ECs. Our results demonstrate that miR-143 and miR-145 act as communication molecules between SMCs and ECs to modulate the angiogenic and vessel stabilization properties of ECs. © 2015 American Heart Association, Inc.

  2. MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma.

    PubMed

    Han, Qiang; Zhang, Hua-Yong; Zhong, Bei-Long; Wang, Xiao-Jing; Zhang, Bing; Chen, Hua

    2016-10-23

    BACKGROUND This study investigated the mechanism of miR-145 in targeting connective tissue growth factor (CTGF), which affects the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of ESCC cells. MATERIAL AND METHODS A total of 50 ESCC tissues and their corresponding normal adjacent esophageal tissue samples were collected. Then, miR-145 expression in both ESCC clinical specimens and cell lines was detected using quantitative real-time PCR. CTGF protein was detected using immunohistochemistry. Dual luciferase reporter gene assay was employed to assess the effect of miR-145 on the 3'UTR luciferase activity of CTGF. Eca109 cells were transfected with miR-145 mimics and CTGF siRNA, respectively, and changes in cellular proliferation, migration, and invasion were detected via MTT assay, wound-healing assay, and Transwell assay, respectively. Western blotting assay was used to detect the expression of marker genes related to EMT. RESULTS MiR-145 was significantly down-regulated in ESCC tissues and cell lines compared with normal tissues and cell lines (P<0.05). We found significantly more positively expressed CTGF protein in ESCC tissues was than in normal adjacent esophageal tissues (P<0.01). Dual luciferase reporter gene assay showed that miR-145 can specifically bind with the 3'UTR of CTGF and significantly inhibit the luciferase activity by 55% (P<0.01). Up-regulation of miR-145 or down-regulation of CTGF can suppress the proliferation, migration, invasion, and EMT process of ESCC cells. CONCLUSIONS MiR-145 was significantly down-regulated in ESCC tissues and cell lines, while the protein expression of CTGF exhibited the opposite trend. MiR-145 inhibited the proliferation, migration, invasiveness, and the EMT process of ESCC cells through targeted regulation of CTGF expression.

  3. Quercetin induces the apoptosis of human ovarian carcinoma cells by upregulating the expression of microRNA-145.

    PubMed

    Zhou, Junbo; Gong, Jian; Ding, Chun; Chen, Guiqin

    2015-08-01

    Ovarian cancer is one of the most malignant types of cancer of the female human reproductive track, posing a severe threat to the health of the female population. Numerous previous studies have demonstrated that microRNA (miR)-145 is downregulated in ovarian cancer, and that quercetin can inhibit the growth of cancer cells via regulating the expression of miRs. Therefore, the present study investigated the effect of quercetin on the expression of miR-145 in SKOV-3 and A2780 human ovarian cancer cell lines. The results revealed that the expression levels of cleaved caspase-3 in the SKOV-3 and A2780 cells were significantly increased following treatment to induce overexpression of miR-145 compared with treatment with quercetin alone (P<0.01). However, the expression of cleaved caspase-3 in the anti-miR-145 (miR-145 inhibitor) group of cells was markedly decreased compared with that in the miR-145 overexpression group (P<0.01). Taken together, the results suggested that treatment with quercetin induced the apoptosis of human ovarian carcinoma cells through activation of the extrinsic death receptor mediated and intrinsic mitochondrial apoptotic pathways.

  4. GATA4-mediated cardiac hypertrophy induced by D-myo-inositol 1,4,5-tris-phosphate

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhu Zhiming; Zhu Shanjun; Liu Daoyan

    2005-12-16

    We evaluated the effects of D-myo-inositol 1,4,5-tris-phosphate on cardiac hypertrophy. D-myo-inositol 1,4,5-tris-phosphate augmented cardiac hypertrophy as evidenced by its effects on DNA synthesis, protein synthesis, and expression of immediate-early genes c-myc and c-fos, {beta}-myosin heavy chain, and {alpha}-actin. The administration of D-myo-inositol 1,4,5-tris-phosphate increased the expression of nuclear factor of activated T-cells and cardiac-restricted zinc finger transcription factor (GATA4). Real-time quantitative RT-PCR showed that D-myo-inositol 1,4,5-tris-phosphate-induced GATA4 mRNA was significantly enhanced even in the presence of the calcineurin inhibitor, cyclosporine A. The effect of D-myo-inositol 1,4,5-tris-phosphate was blocked after inhibition of inositol-trisphosphate receptors but not after inhibition of c-Raf/mitogen-activated proteinmore » kinase kinase (MEK)/mitogen-activated protein kinase (ERK) or p38 mitogen-activated protein kinase pathways. The study shows that D-myo-inositol 1,4,5-tris-phosphate-induced cardiac hypertrophy is mediated by GATA4 but independent from the calcineurin pathway.« less

  5. [Analysis on the relationship between malaria epidemics and NOAA-AVHRR NDVI in Hainan province].

    PubMed

    Wen, Liang; Xu, De-zhong; Wang, Shan-qing; Li, Cai-xu; Zhang, Zhi-ying; Su, Yong-qiang

    2005-04-01

    To explore the relationship between malaria epidemics and NOAA-AVHRR NDVI. Data on malaria were collected in all 19 counties in Hainan province from Feb, 1995 to Jan, 1996. Values regarding normalized difference vegetation index (NDVI)-related indicators including mean and maximum values of NDVI, the area proportion of NDVI values of 145- and 145+, months with NDVI values of 135+, 140+, 145+, 150+ of these counties in this period were all extracted from NOAA-AVHRR images, using ERDAS8.5 software. The coefficients of correlation of malaria incidences and these NDVI-related indicator values were then calculated with SPSS 11.0. The incidence of malaria showed positive correlations to mean and maximum values of NDVI, the area proportion of NDVI values of 145+ and months with NDVI values of 135+, 140+, 145+, 150+ respectively, but having negative correlation to the area of NDVI values of 145-. The malaria epidemic regions were in accordance with those regions that the NDVI values of 145+ were continuing for 9 months or more. Malaria prevalence was associated with NOAA-AVHRR NDVI value which could be considered to be use for malaria surveillance in Hainan province.

  6. 40 CFR 415.145 - New source performance standards (NSPS).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true New source performance standards (NSPS). 415.145 Section 415.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Sodium Bicarbonate...

  7. 40 CFR 415.145 - New source performance standards (NSPS).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true New source performance standards (NSPS). 415.145 Section 415.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Sodium Bicarbonate...

  8. 40 CFR 415.145 - New source performance standards (NSPS).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true New source performance standards (NSPS). 415.145 Section 415.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Sodium Bicarbonate...

  9. 40 CFR 415.145 - New source performance standards (NSPS).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false New source performance standards (NSPS). 415.145 Section 415.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Sodium Bicarbonate...

  10. 40 CFR 415.145 - New source performance standards (NSPS).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true New source performance standards (NSPS). 415.145 Section 415.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Sodium Bicarbonate...

  11. 22 CFR 145.5 - Subawards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Subawards. 145.5 Section 145.5 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION... subrecipients performing work under awards if such subrecipients are institutions of higher education, hospitals...

  12. 22 CFR 145.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose. 145.1 Section 145.1 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND... higher-education, hospitals, other nonprofit organizations, and commercial organizations, except that...

  13. 14 CFR 145.103 - Housing and facilities requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....103 Section 145.103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.103 Housing and facilities requirements. (a) Each certificated repair station must provide— (1) Housing for the facilities, equipment, materials, and personnel consistent with its ratings...

  14. 14 CFR 145.103 - Housing and facilities requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....103 Section 145.103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.103 Housing and facilities requirements. (a) Each certificated repair station must provide— (1) Housing for the facilities, equipment, materials, and personnel consistent with its ratings...

  15. 14 CFR 145.103 - Housing and facilities requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....103 Section 145.103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.103 Housing and facilities requirements. (a) Each certificated repair station must provide— (1) Housing for the facilities, equipment, materials, and personnel consistent with its ratings...

  16. 14 CFR 145.103 - Housing and facilities requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....103 Section 145.103 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF..., Materials, and Data § 145.103 Housing and facilities requirements. (a) Each certificated repair station must provide— (1) Housing for the facilities, equipment, materials, and personnel consistent with its ratings...

  17. Historical cohort study of US man-made vitreous fiber production workers: VIII. Exposure-specific job analysis.

    PubMed

    Quinn, M M; Smith, T J; Youk, A O; Marsh, G M; Stone, R A; Buchanich, J M; Gula, M J

    2001-09-01

    All jobs held by a cohort of US man-made vitreous fiber production workers were analyzed for airborne fiber exposure. This exposure-specific job analysis was part of an exposure assessment for an epidemiologic study of mortality patterns, with particular focus on respiratory cancer, among 35,145 workers employed in 10 fiberglass and five rock or slag wool plants. The exposure assessment was conducted from the start-up date of each plant (1917 to 1946) to 1990. For the job analysis, 15,465 crude department names and 47,693 crude job titles were grouped into 1668 unique department and job pairs (UDJobs), which represented a job title linked to a specific department within each plant. Every UDJob was evaluated according to a set of job elements related to airborne fiber exposure. The distribution of the cohort person-years by UDJob and the job-exposure elements was then evaluated. The results show the main departments and jobs that employed the workers for each plant. The distribution of person-years varies across the job-exposure elements. The same job title was used in different departments within and across plants. When job titles not linked to departments were evaluated, the values of the job-exposure elements varied considerably across all plants and within plant. (1) exposure misclassification could occur if job title alone were used for the exposure assessment; (2) the job-exposure elements analysis provides an efficient way to identify major job determinants of exposure without relying on the more detailed, resource-intensive task-based approach; and (3) the evaluation of the cohort person-years by UDJobs and job-exposure elements is an effective way to identify which plants, departments, and jobs have sufficient information for making precise risk estimates in the broader epidemiologic study.

  18. Targeting human breast cancer cells by an oncolytic adenovirus using microRNA-targeting strategy.

    PubMed

    Shayestehpour, Mohammad; Moghim, Sharareh; Salimi, Vahid; Jalilvand, Somayeh; Yavarian, Jila; Romani, Bizhan; Mokhtari-Azad, Talat

    2017-08-15

    MicroRNA-targeting strategy is a promising approach that enables oncolytic viruses to replicate in tumor cells but not in normal cells. In this study, we targeted adenoviral replication toward breast cancer cells by inserting ten complementary binding sites for miR-145-5p downstream of E1A gene. In addition, we evaluated the effect of increasing miR-145 binding sites on inhibition of virus replication. Ad5-control and adenoviruses carrying five or ten copies of miR145-5p target sites (Ad5-5miR145T, Ad5-10miR145T) were generated and inoculated into MDA-MB-453, BT-20, MCF-7 breast cancer cell lines and human mammary epithelial cells (HMEpC). Titer of Ad5-10miR145T in HMEpC was significantly lower than Ad5-control titer. Difference between the titer of these two viruses at 12, 24, 36, and 48h after infection was 1.25, 2.96, 3.06, and 3.77 log TCID 50 . No significant difference was observed between the titer of both adenoviruses in MDA-MB-453, BT-20 and MCF-7 cells. The infectious titer of adenovirus containing 10 miR-145 binding sites in HMEpC cells at 24, 36, and 48h post-infection was 1.7, 2.08, and 4-fold, respectively, lower than the titer of adenovirus carrying 5 miR-145 targets. Our results suggest that miR-145-targeting strategy provides selectivity for adenovirus replication in breast cancer cells. Increasing the number of miRNA binding sites within the adenoviral genome confers more selectivity for viral replication in cancer cells. Copyright © 2017. Published by Elsevier B.V.

  19. Cloning, Site-Directed Mutagenesis, and Functional Analysis of Active Residues in Lymantria dispar Chitinase.

    PubMed

    Fan, Xiao-Jun; Yang, Chun; Zhang, Chang; Ren, Hui; Zhang, Jian-Dong

    2018-01-01

    Chitinases are glycosyl hydrolases that catalyze the hydrolysis of β-(1,4)-glycosidic bonds in chitin, the major structural polysaccharide presented in the cuticle and gut peritrophic matrix of insects. Two aspartate residues (D143, D145) and one tryptophan (W146) in the Lymantria dispar chitinase are highly conserved residues observed within the second conserved motif of the family 18 chitinase catalytic region. In this study, a chitinase cDNA, LdCht5, was cloned from L. dispar, and the roles of the three residues were investigated using site-directed mutagenesis and substituting them with three other amino acids. Seven mutant proteins, D143E, D145E, W146G, D143E/D145E, D143E/W146G, D145E/W146G, and D143E/D145E/W146G, as well as the wild-type enzyme, were produced using the baculovirus-insect cell line expression system. The enzymatic and kinetic properties of these mutant enzymes were measured using the oligosaccharide substrate MU-(GlcNAc) 3 . Among the seven mutants, the D145E, D143E/D145E, and D145E/W146G mutations kept some extant catalytic activity toward MU-(GlcNAc) 3 , while the D143E, W146G, D143E/W146G, and D143E/D145E/W146G mutant enzymes were inactivated. Compared with the mutant enzymes, the wild-type enzyme had higher values of k cat and k cat / K m . A study of the multiple point mutations in the second conserved catalytic region would help to elucidate the role of the critical residues and their relationships.

  20. 21 CFR 189.145 - Dulcin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

  1. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  2. 9 CFR 145.4 - General provisions for all participants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... participants. 145.4 Section 145.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY..., for use in breeding flocks or for experimental purposes, under the following conditions only: (1) With...

  3. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  4. 9 CFR 145.4 - General provisions for all participants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... participants. 145.4 Section 145.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY..., for use in breeding flocks or for experimental purposes, under the following conditions only: (1) With...

  5. 14 CFR 145.151 - Personnel requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Personnel requirements. 145.151 Section 145.151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... specifications; (c) Ensure it has a sufficient number of employees with the training or knowledge and experience...

  6. 14 CFR 145.151 - Personnel requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Personnel requirements. 145.151 Section 145.151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... specifications; (c) Ensure it has a sufficient number of employees with the training or knowledge and experience...

  7. 40 CFR 408.145 - Standards of performance for new sources.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true Standards of performance for new sources. 408.145 Section 408.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna...

  8. 40 CFR 408.145 - Standards of performance for new sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true Standards of performance for new sources. 408.145 Section 408.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna...

  9. 40 CFR 408.145 - Standards of performance for new sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false Standards of performance for new sources. 408.145 Section 408.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna...

  10. 40 CFR 408.145 - Standards of performance for new sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Standards of performance for new sources. 408.145 Section 408.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna...

  11. 40 CFR 408.145 - Standards of performance for new sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Standards of performance for new sources. 408.145 Section 408.145 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED SEAFOOD PROCESSING POINT SOURCE CATEGORY Tuna...

  12. 17 CFR 14.5 - Criminal conviction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Criminal conviction. 14.5 Section 14.5 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO... felony or of a misdemeanor involving fraud or involving moral turpitude in matters related to the...

  13. 12 CFR 390.145 - Nondiscriminatory advertising.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Nondiscriminatory advertising. 390.145 Section....145 Nondiscriminatory advertising. No State savings association may directly or indirectly engage in any form of advertising that implies or suggests a policy of discrimination or exclusion in violation...

  14. 12 CFR 390.145 - Nondiscriminatory advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Nondiscriminatory advertising. 390.145 Section....145 Nondiscriminatory advertising. No State savings association may directly or indirectly engage in any form of advertising that implies or suggests a policy of discrimination or exclusion in violation...

  15. 12 CFR 390.145 - Nondiscriminatory advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Nondiscriminatory advertising. 390.145 Section....145 Nondiscriminatory advertising. No State savings association may directly or indirectly engage in any form of advertising that implies or suggests a policy of discrimination or exclusion in violation...

  16. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  17. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  18. 9 CFR 145.8 - Terminology and classification; general.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Terminology and classification; general. 145.8 Section 145.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  19. 21 CFR 189.145 - Dulcin.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

  20. 21 CFR 189.145 - Dulcin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From...

  1. 40 CFR 145.24 - Attorney General's statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Attorney General's statement. 145.24... (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.24 Attorney General's statement... State Attorney General (or the attorney for those State or interstate agencies which have independent...

  2. 40 CFR 440.145-440.147 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false [Reserved] 440.145-440.147 Section 440.145-440.147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold Placer Mine Subcategory...

  3. 40 CFR 440.145-440.147 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false [Reserved] 440.145-440.147 Section 440.145-440.147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold Placer Mine Subcategory...

  4. 40 CFR 440.145-440.147 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false [Reserved] 440.145-440.147 Section 440.145-440.147 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) ORE MINING AND DRESSING POINT SOURCE CATEGORY Gold Placer Mine Subcategory...

  5. 22 CFR 145.40 - Purpose of procurement standards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose of procurement standards. 145.40 Section 145.40 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements...

  6. 22 CFR 145.30 - Purpose of property standards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Purpose of property standards. 145.30 Section 145.30 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Property...

  7. P-Element Insertion Alleles of Essential Genes on the Third Chromosome of Drosophila Melanogaster: Correlation of Physical and Cytogenetic Maps in Chromosomal Region 86e-87f

    PubMed Central

    Deak, P.; Omar, M. M.; Saunders, RDC.; Pal, M.; Komonyi, O.; Szidonya, J.; Maroy, P.; Zhang, Y.; Ashburner, M.; Benos, P.; Savakis, C.; Siden-Kiamos, I.; Louis, C.; Bolshakov, V. N.; Kafatos, F. C.; Madueno, E.; Modolell, J.; Glover, D. M.

    1997-01-01

    We have established a collection of 2460 lethal or semi-lethal mutant lines using a procedure thought to insert single P elements into vital genes on the third chromosome of Drosophila melanogaster. More than 1200 randomly selected lines were examined by in situ hybridization and 90% found to contain single insertions at sites that mark 89% of all lettered subdivisions of the Bridges' map. A set of chromosomal deficiencies that collectively uncover ~25% of the euchromatin of chromosome 3 reveal lethal mutations in 468 lines corresponding to 145 complementation groups. We undertook a detailed analysis of the cytogenetic interval 86E-87F and identified 87 P-element-induced mutations falling into 38 complementation groups, 16 of which correspond to previously known genes. Twenty-one of these 38 complementation groups have at least one allele that has a P-element insertion at a position consistent with the cytogenetics of the locus. We have rescued P elements and flanking chromosomal sequences from the 86E-87F region in 35 lines with either lethal or genetically silent P insertions, and used these as probes to identify cosmids and P1 clones from the Drosophila genome projects. This has tied together the physical and genetic maps and has linked 44 previously identified cosmid contigs into seven ``supercontigs'' that span the interval. STS data for sequences flanking one side of the P-element insertions in 49 lines has identified insertions in the αγ element at 87C, two known transposable elements, and the open reading frames of seven putative single copy genes. These correspond to five known genes in this interval, and two genes identified by the homology of their predicted products to known proteins from other organisms. PMID:9409831

  8. Comparative genomics of enterohemorrhagic Escherichia coli O145:H28 demonstrates a common evolutionary lineage with Escherichia coli O157:H7

    PubMed Central

    2014-01-01

    Background Although serotype O157:H7 is the predominant enterohemorrhagic Escherichia coli (EHEC), outbreaks of non-O157 EHEC that cause severe foodborne illness, including hemolytic uremic syndrome have increased worldwide. In fact, non-O157 serotypes are now estimated to cause over half of all the Shiga toxin-producing Escherichia coli (STEC) cases, and outbreaks of non-O157 EHEC infections are frequently associated with serotypes O26, O45, O103, O111, O121, and O145. Currently, there are no complete genomes for O145 in public databases. Results We determined the complete genome sequences of two O145 strains (EcO145), one linked to a US lettuce-associated outbreak (RM13514) and one to a Belgium ice-cream-associated outbreak (RM13516). Both strains contain one chromosome and two large plasmids, with genome sizes of 5,737,294 bp for RM13514 and 5,559,008 bp for RM13516. Comparative analysis of the two EcO145 genomes revealed a large core (5,173 genes) and a considerable amount of strain-specific genes. Additionally, the two EcO145 genomes display distinct chromosomal architecture, virulence gene profile, phylogenetic origin of Stx2a prophage, and methylation profile (methylome). Comparative analysis of EcO145 genomes to other completely sequenced STEC and other E. coli and Shigella genomes revealed that, unlike any other known non-O157 EHEC strain, EcO145 ascended from a common lineage with EcO157/EcO55. This evolutionary relationship was further supported by the pangenome analysis of the 10 EHEC str ains. Of the 4,192 EHEC core genes, EcO145 shares more genes with EcO157 than with the any other non-O157 EHEC strains. Conclusions Our data provide evidence that EcO145 and EcO157 evolved from a common lineage, but ultimately each serotype evolves via a lineage-independent nature to EHEC by acquisition of the core set of EHEC virulence factors, including the genes encoding Shiga toxin and the large virulence plasmid. The large variation between the two EcO145 genomes suggests a distinctive evolutionary path between the two outbreak strains. The distinct methylome between the two EcO145 strains is likely due to the presence of a BsuBI/PstI methyltransferase gene cassette in the Stx2a prophage of the strain RM13514, suggesting a role of horizontal gene transfer-mediated epigenetic alteration in the evolution of individual EHEC strains. PMID:24410921

  9. CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway.

    PubMed

    Hung, Chao-Ming; Lin, Ying-Chao; Liu, Liang-Chih; Kuo, Sheng-Chu; Ho, Chi-Tang; Way, Tzong-Der

    2016-12-25

    CWF-145, a synthetic 2-phenyl-4-quinolone derivative exerted potent cytotoxicity against prostate cancer. CWF-145 inhibited prostate cancer cell lines PC-3, DU-145 and LNCap. It had a very low IC 50 about 200 nM against castrate-resistant prostate cancer (CRPC) PC-3. We found that CWF-145 had a similar effect to clinical trial antimitotic agents in cancer cells and normal cells. CWF-145 arrested cell cycle at G2/M phase by binding to the β-tubulin at the colchicine-binding site then disrupted microtubule polymerization. Furthermore, the damaged microtubule affected the Akt/mammalian target of rapamycin (mTOR) signaling pathway. Our data showed that CWF-145 activated Akt and mTOR expression to increase emi1 accumulation and inhibit APC. The increased cyclin B1 and securin arrested cell cycle at G2/M phase. Moreover, we showed that Akt activation markedly increased resistance to microtubule-directed agents, including CWF-145, colchicine, and paclitaxel. Interestingly, rapamycin inhibited Akt-mediated therapeutic resistance, indicating that these effects were dependent on mTOR. Taken together, these observations suggest that activation of the Akt/mTOR signaling pathway can promote resistance to chemotherapeutic agents that do not directly target metabolic regulation. These data may provide insight into potentially synergistic combinations of anticancer therapies. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. 22 CFR 145.28 - Period of availability of funds.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 145.28 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 145.28 Period of availability of funds. Where a funding period is specified, a...

  11. 9 CFR 145.6 - Specific provisions for participating hatcheries.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... hatcheries. 145.6 Section 145.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY... for sale under Plan terminology should be normal and typical of the breed, variety, cross, or other...

  12. 9 CFR 145.5 - Specific provisions for participating flocks.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... flocks. 145.5 Section 145.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY... characteristic of the breed, variety, cross, or other combination which they are stated to represent. (c) A flock...

  13. 9 CFR 145.9 - Terminology and classification; hatcheries and dealers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; hatcheries and dealers. 145.9 Section 145.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  14. 9 CFR 145.5 - Specific provisions for participating flocks.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... flocks. 145.5 Section 145.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY... characteristic of the breed, variety, cross, or other combination which they are stated to represent. (c) A flock...

  15. 9 CFR 145.9 - Terminology and classification; hatcheries and dealers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Terminology and classification; hatcheries and dealers. 145.9 Section 145.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  16. 9 CFR 145.6 - Specific provisions for participating hatcheries.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... hatcheries. 145.6 Section 145.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY... for sale under Plan terminology should be normal and typical of the breed, variety, cross, or other...

  17. 21 CFR 172.145 - Heptylparaben.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Heptylparaben. 172.145 Section 172.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Food...

  18. 36 CFR 223.145 - Scope of suspension.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Scope of suspension. 223.145 Section 223.145 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS...

  19. 36 CFR 223.145 - Scope of suspension.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Scope of suspension. 223.145 Section 223.145 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS...

  20. 36 CFR 223.145 - Scope of suspension.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Scope of suspension. 223.145 Section 223.145 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS...

  1. 36 CFR 223.145 - Scope of suspension.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Scope of suspension. 223.145 Section 223.145 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS...

  2. 33 CFR 211.145 - Filing of application.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 211.145 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Conveyances for Public Port Or Industrial Facilities § 211.145 Filing of application. Any agency interested in...

  3. 21 CFR 133.145 - Granular cheese for manufacturing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Granular cheese for manufacturing. 133.145 Section... (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.145 Granular cheese for manufacturing. Granular cheese for...

  4. 21 CFR 133.145 - Granular cheese for manufacturing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Granular cheese for manufacturing. 133.145 Section... (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.145 Granular cheese for manufacturing. Granular cheese for...

  5. 33 CFR 211.145 - Filing of application.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 211.145 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE ACTIVITIES OF THE CORPS OF ENGINEERS IN CONNECTION WITH CIVIL WORKS PROJECTS Conveyances for Public Port Or Industrial Facilities § 211.145 Filing of application. Any agency interested in...

  6. 27 CFR 20.145 - Encased containers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Encased containers. 20.145... Denatured Alcohol § 20.145 Encased containers. Completely denatured alcohol may be packaged by distributors in unlabeled containers which are completely encased in wood, fiberboard, or similar material so that...

  7. 30 CFR 14.5 - Test samples.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Test samples. 14.5 Section 14.5 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF... Test samples. Upon request by MSHA, the applicant must submit 3 precut, unrolled, flat conveyor belt...

  8. 30 CFR 14.5 - Test samples.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Test samples. 14.5 Section 14.5 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF... Test samples. Upon request by MSHA, the applicant must submit 3 precut, unrolled, flat conveyor belt...

  9. 30 CFR 14.5 - Test samples.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Test samples. 14.5 Section 14.5 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF... Test samples. Upon request by MSHA, the applicant must submit 3 precut, unrolled, flat conveyor belt...

  10. 9 CFR 145.9 - Terminology and classification; hatcheries and dealers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Terminology and classification; hatcheries and dealers. 145.9 Section 145.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  11. 9 CFR 145.9 - Terminology and classification; hatcheries and dealers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Terminology and classification; hatcheries and dealers. 145.9 Section 145.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  12. 9 CFR 145.9 - Terminology and classification; hatcheries and dealers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Terminology and classification; hatcheries and dealers. 145.9 Section 145.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  13. 17 CFR 145.0 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INFORMATION § 145.0 Definitions. For the purposes of part 145 the following definitions are applicable: Assistant Secretary—refers to the Assistant Secretary of the Commission for FOI, Privacy and Sunshine Acts Compliance. Compliance staff—refers to the FOI, Privacy and Sunshine Acts Compliance staff of the Office of...

  14. 7 CFR 762.145 - Restructuring guaranteed loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... calculations required in paragraph (e) of this section for debt writedown. (iii) For restructuring other than... 7 Agriculture 7 2011-01-01 2011-01-01 false Restructuring guaranteed loans. 762.145 Section 762..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.145 Restructuring guaranteed loans. (a...

  15. 7 CFR 762.145 - Restructuring guaranteed loans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... calculations required in paragraph (e) of this section for debt writedown. (iii) For restructuring other than... 7 Agriculture 7 2012-01-01 2012-01-01 false Restructuring guaranteed loans. 762.145 Section 762..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.145 Restructuring guaranteed loans. (a...

  16. 46 CFR 133.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Marine evacuation system launching arrangements. 133.145... LIFESAVING SYSTEMS Requirements for All OSVs § 133.145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system must have the following arrangements: (1) Each marine evacuation...

  17. 46 CFR 133.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Marine evacuation system launching arrangements. 133.145... LIFESAVING SYSTEMS Requirements for All OSVs § 133.145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system must have the following arrangements: (1) Each marine evacuation...

  18. 46 CFR 133.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Marine evacuation system launching arrangements. 133.145... LIFESAVING SYSTEMS Requirements for All OSVs § 133.145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system must have the following arrangements: (1) Each marine evacuation...

  19. 46 CFR 133.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Marine evacuation system launching arrangements. 133.145... LIFESAVING SYSTEMS Requirements for All OSVs § 133.145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system must have the following arrangements: (1) Each marine evacuation...

  20. 22 CFR 145.22 - Payment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Payment. 145.22 Section 145.22 Foreign....22 Payment. (a) Payment methods shall minimize the time elapsing between the transfer of funds from... request for reimbursement at least monthly when electronic funds transfers are not used. (f) If a...

  1. 22 CFR 145.22 - Payment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Payment. 145.22 Section 145.22 Foreign....22 Payment. (a) Payment methods shall minimize the time elapsing between the transfer of funds from... request for reimbursement at least monthly when electronic funds transfers are not used. (f) If a...

  2. 22 CFR 145.22 - Payment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Payment. 145.22 Section 145.22 Foreign....22 Payment. (a) Payment methods shall minimize the time elapsing between the transfer of funds from... request for reimbursement at least monthly when electronic funds transfers are not used. (f) If a...

  3. 22 CFR 145.22 - Payment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Payment. 145.22 Section 145.22 Foreign....22 Payment. (a) Payment methods shall minimize the time elapsing between the transfer of funds from... request for reimbursement at least monthly when electronic funds transfers are not used. (f) If a...

  4. 22 CFR 145.21 - Standards for financial management systems.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards for financial management systems. 145... Financial and Program Management § 145.21 Standards for financial management systems. (a) The Department... whenever practical. (b) Recipients' financial management systems shall provide for the following. (1...

  5. 9 CFR 145.2 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Administration. 145.2 Section 145.2... Administration. (a) The Department cooperates through a Memorandum of Understanding with Official State Agencies in the administration of the Plan. In the Memorandum of Understanding, the Official State Agency must...

  6. 9 CFR 145.2 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Administration. 145.2 Section 145.2... Administration. (a) The Department cooperates through a Memorandum of Understanding with Official State Agencies in the administration of the Plan. In the Memorandum of Understanding, the Official State Agency must...

  7. 9 CFR 145.2 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Administration. 145.2 Section 145.2... Administration. (a) The Department cooperates through a Memorandum of Understanding with Official State Agencies in the administration of the Plan. In the Memorandum of Understanding, the Official State Agency must...

  8. 9 CFR 145.5 - Specific provisions for participating flocks.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... characteristic of the breed, variety, cross, or other combination which they are stated to represent. (c) A flock... flocks. 145.5 Section 145.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  9. 9 CFR 145.5 - Specific provisions for participating flocks.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... characteristic of the breed, variety, cross, or other combination which they are stated to represent. (c) A flock... flocks. 145.5 Section 145.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  10. 9 CFR 145.5 - Specific provisions for participating flocks.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... characteristic of the breed, variety, cross, or other combination which they are stated to represent. (c) A flock... flocks. 145.5 Section 145.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY...

  11. 22 CFR 145.72 - Subsequent adjustments and continuing responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Subsequent adjustments and continuing responsibilities. 145.72 Section 145.72 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS After-the-Award...

  12. Long noncoding RNA MALAT1 enhances the docetaxel resistance of prostate cancer cells via miR-145-5p-mediated regulation of AKAP12.

    PubMed

    Xue, Dong; Lu, Hao; Xu, Han-Yan; Zhou, Cui-Xing; He, Xiao-Zhou

    2018-06-01

    Our present work was aimed to study on the regulatory role of MALAT1/miR-145-5p/AKAP12 axis on docetaxel (DTX) sensitivity of prostate cancer (PCa) cells. The microarray data (GSE33455) to identify differentially expressed lncRNAs and mRNAs in DTX-resistant PCa cell lines (DU-145-DTX and PC-3-DTX) was retrieved from the Gene Expression Omnibus (GEO) database. QRT-PCR analysis was performed to measure MALAT1 expression in DTX-sensitive and DTX-resistant tissues/cells. The human DTX-resistant cell lines DU145-PTX and PC3-DTX were established as in vitro cell models, and the expression of MALAT1, miR-145-5p and AKAP12 was manipulated in DTX-sensitive and DTX-resistant cells. Cell viability was examined using MTT assay and colony formation methods. Cell apoptosis was assessed by TUNEL staining. Cell migration and invasion was determined by scratch test (wound healing) and Transwell assay, respectively. Dual-luciferase assay was applied to analyse the target relationship between lncRNA MALAT1 and miR-145-5p, as well as between miR-145-5p and AKAP12. Tumour xenograft study was undertaken to confirm the correlation of MALAT1/miR-145-5p/AKAP12 axis and DTX sensitivity of PCa cells in vivo. In this study, we firstly notified that the MALAT1 expression levels were up-regulated in clinical DTX-resistant PCa samples. Overexpressed MALAT1 promoted cell proliferation, migration and invasion but decreased cell apoptosis rate of PCa cells in spite of DTX treatment. We identified miR-145-5p as a target of MALAT1. MiR-145-5p overexpression in PC3-DTX led to inhibited cell proliferation, migration and invasion as well as reduced chemoresistance to DTX, which was attenuated by MALAT1. Moreover, we determined that AKAP12 was a target of miR-145-5p, which significantly induced chemoresistance of PCa cells to DTX. Besides, it was proved that MALAT1 promoted tumour cell proliferation and enhanced DTX-chemoresistance in vivo. There was an lncRNA MALAT1/miR-145-5p/AKAP12 axis involved in DTX resistance of PCa cells and provided a new thought for PCa therapy. © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  13. Identification and apportionment of hazardous elements in the sediments in the Yangtze River estuary.

    PubMed

    Wang, Jiawei; Liu, Ruimin; Wang, Haotian; Yu, Wenwen; Xu, Fei; Shen, Zhenyao

    2015-12-01

    In this study, positive matrix factorization (PMF) and principal components analysis (PCA) were combined to identify and apportion pollution-based sources of hazardous elements in the surface sediments in the Yangtze River estuary (YRE). Source identification analysis indicated that PC1, including Al, Fe, Mn, Cr, Ni, As, Cu, and Zn, can be defined as a sewage component; PC2, including Pb and Sb, can be considered as an atmospheric deposition component; and PC3, containing Cd and Hg, can be considered as an agricultural nonpoint component. To better identify the sources and quantitatively apportion the concentrations to their sources, eight sources were identified with PMF: agricultural/industrial sewage mixed (18.6 %), mining wastewater (15.9 %), agricultural fertilizer (14.5 %), atmospheric deposition (12.8 %), agricultural nonpoint (10.6 %), industrial wastewater (9.8 %), marine activity (9.0 %), and nickel plating industry (8.8 %). Overall, the hazardous element content seems to be more connected to anthropogenic activity instead of natural sources. The PCA results laid the foundation for the PMF analysis by providing a general classification of sources. PMF resolves more factors with a higher explained variance than PCA; PMF provided both the internal analysis and the quantitative analysis. The combination of the two methods can provide more reasonable and reliable results.

  14. 21 CFR 145.134 - Canned preserved figs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...

  15. 21 CFR 145.130 - Canned figs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Canned figs. 145.130 Section 145.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...) Ingredients. Canned figs is the food prepared from one of the optional fig ingredients specified in paragraph...

  16. 21 CFR 145.134 - Canned preserved figs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...

  17. 21 CFR 145.130 - Canned figs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Canned figs. 145.130 Section 145.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...) Ingredients. Canned figs is the food prepared from one of the optional fig ingredients specified in paragraph...

  18. 21 CFR 145.130 - Canned figs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Canned figs. 145.130 Section 145.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...) Ingredients. Canned figs is the food prepared from one of the optional fig ingredients specified in paragraph...

  19. 21 CFR 145.134 - Canned preserved figs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...

  20. 21 CFR 145.134 - Canned preserved figs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Canned preserved figs. 145.134 Section 145.134 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Canned preserved figs. (a) Canned preserved figs is the food prepared from one of the optional fig...

  1. 22 CFR 145.25 - Revision of budget and program plans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 145.25 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 145.25 Revision of budget and program plans. (a) The budget plan is the...

  2. 9 CFR 145.4 - General provisions for all participants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false General provisions for all participants. 145.4 Section 145.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... of all birds before introduction into the breeding flock. Upon reaching sexual maturity, the...

  3. 9 CFR 145.4 - General provisions for all participants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false General provisions for all participants. 145.4 Section 145.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... of all birds before introduction into the breeding flock. Upon reaching sexual maturity, the...

  4. 9 CFR 145.4 - General provisions for all participants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false General provisions for all participants. 145.4 Section 145.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... of all birds before introduction into the breeding flock. Upon reaching sexual maturity, the...

  5. 50 CFR 217.145 - Measures to ensure availability of species for subsistence uses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Measures to ensure availability of species for subsistence uses. 217.145 Section 217.145 Wildlife and Fisheries NATIONAL MARINE FISHERIES... affected subsistence communities to discuss proposed activities and to resolve potential conflicts...

  6. 19 CFR 145.35 - United States products returned.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false United States products returned. 145.35 Section... OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.35 United States products returned. Products of the United States returned after having been exported, which have not been...

  7. 19 CFR 145.35 - United States products returned.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false United States products returned. 145.35 Section... OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.35 United States products returned. Products of the United States returned after having been exported, which have not been...

  8. 19 CFR 145.35 - United States products returned.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false United States products returned. 145.35 Section... OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.35 United States products returned. Products of the United States returned after having been exported, which have not been...

  9. 19 CFR 145.35 - United States products returned.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false United States products returned. 145.35 Section... OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.35 United States products returned. Products of the United States returned after having been exported, which have not been...

  10. 19 CFR 145.35 - United States products returned.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false United States products returned. 145.35 Section... OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Special Classes of Merchandise § 145.35 United States products returned. Products of the United States returned after having been exported, which have not been...

  11. 21 CFR 145.110 - Canned applesauce.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... throughout the expected shelf life of the food under customary conditions of distribution. (ix) Color... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Canned applesauce. 145.110 Section 145.110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  12. 21 CFR 145.110 - Canned applesauce.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... throughout the expected shelf life of the food under customary conditions of distribution. (ix) Color... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Canned applesauce. 145.110 Section 145.110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  13. 21 CFR 145.110 - Canned applesauce.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... throughout the expected shelf life of the food under customary conditions of distribution. (ix) Color... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Canned applesauce. 145.110 Section 145.110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  14. 9 CFR 145.10 - Terminology and classification; flocks, products, and States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Terminology and classification; flocks, products, and States. 145.10 Section 145.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  15. 9 CFR 145.10 - Terminology and classification; flocks, products, and States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; flocks, products, and States. 145.10 Section 145.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING...

  16. 22 CFR 145.52 - Financial reporting.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Financial reporting. 145.52 Section 145.52....52 Financial reporting. (a) The following forms or such other forms as may be approved by OMB are authorized for obtaining financial information from recipients. (1) SF-269 or SF-269A, Financial Status...

  17. 45 CFR 147.145 - Student health insurance coverage.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Student health insurance coverage. 147.145 Section 147.145 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE REFORM REQUIREMENTS FOR THE GROUP AND INDIVIDUAL HEALTH INSURANCE MARKETS § 147...

  18. 45 CFR 147.145 - Student health insurance coverage.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Student health insurance coverage. 147.145 Section 147.145 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE REFORM REQUIREMENTS FOR THE GROUP AND INDIVIDUAL HEALTH INSURANCE MARKETS § 147...

  19. 45 CFR 147.145 - Student health insurance coverage.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Student health insurance coverage. 147.145 Section 147.145 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH INSURANCE REFORM REQUIREMENTS FOR THE GROUP AND INDIVIDUAL HEALTH INSURANCE MARKETS § 147...

  20. 21 CFR 145.110 - Canned applesauce.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... additives in such quantity as to distinctly characterize the food unless such addition conceals damage or... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Canned applesauce. 145.110 Section 145.110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  1. 32 CFR 145.6 - Procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... proceeding before the MSPB. (iv) Ensure that information concerning members of the Armed Forces who are found... 32 National Defense 1 2011-07-01 2011-07-01 false Procedures. 145.6 Section 145.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN COOPERATION WITH...

  2. 32 CFR 145.6 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... proceeding before the MSPB. (iv) Ensure that information concerning members of the Armed Forces who are found... 32 National Defense 1 2010-07-01 2010-07-01 false Procedures. 145.6 Section 145.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN COOPERATION WITH...

  3. 19 CFR Policy Statement to Part 145 - Examination of Sealed Letter Class Mail

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Policy Statement to Part 145 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Pt. 145, Policy Stmt. Policy Statement... policies will lead to appropriate administrative sanctions, as well as possible criminal prosecution...

  4. 19 CFR Policy Statement to Part 145 - Examination of Sealed Letter Class Mail

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Policy Statement to Part 145 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Pt. 145, Policy Stmt. Policy Statement... policies will lead to appropriate administrative sanctions, as well as possible criminal prosecution...

  5. 19 CFR Policy Statement to Part 145 - Examination of Sealed Letter Class Mail

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Policy Statement to Part 145 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Pt. 145, Policy Stmt. Policy Statement... policies will lead to appropriate administrative sanctions, as well as possible criminal prosecution...

  6. 19 CFR Policy Statement to Part 145 - Examination of Sealed Letter Class Mail

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Policy Statement to Part 145 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS Pt. 145, Policy Stmt. Policy Statement... policies will lead to appropriate administrative sanctions, as well as possible criminal prosecution...

  7. 24 CFR 964.145 - Conflict of interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Conflict of interest. 964.145 Section 964.145 Housing and Urban Development Regulations Relating to Housing and Urban Development... Conflict of interest. Resident council officers can not serve as contractors or employees if they are in...

  8. 22 CFR 145.24 - Program income.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Program income. 145.24 Section 145.24 Foreign....24 Program income. (a) The Department shall apply the standards set forth in this section in requiring recipient organizations to account for program income related to projects financed in whole or in...

  9. 17 CFR 145.1 - Information published in the Federal Register.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Information published in the... COMMISSION COMMISSION RECORDS AND INFORMATION § 145.1 Information published in the Federal Register. Except as provided in § 145.5, pertaining to nonpublic matters, the following materials shall be published...

  10. 21 CFR 189.145 - Dulcin.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Dulcin. 189.145 Section 189.145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Substances Generally Prohibited From Direct Addition or Use as Human Food § 189...

  11. 9 CFR 145.12 - Inspections.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Inspections. 145.12 Section 145.12 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE..., “Flock Selecting and Testing Report”; VS Form 9-3, “Report of Sales of Hatching Eggs, Chicks, and Poults...

  12. 9 CFR 145.12 - Inspections.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Inspections. 145.12 Section 145.12 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE..., “Flock Selecting and Testing Report”; VS Form 9-3, “Report of Sales of Hatching Eggs, Chicks, and Poults...

  13. 9 CFR 145.12 - Inspections.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Inspections. 145.12 Section 145.12 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE..., “Flock Selecting and Testing Report”; VS Form 9-3, “Report of Sales of Hatching Eggs, Chicks, and Poults...

  14. 17 CFR 145.7 - Requests for Commission records and copies thereof.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Requests for Commission records and copies thereof. 145.7 Section 145.7 Commodity and Securities Exchanges COMMODITY FUTURES... issue an initial determination with respect to a FOIA request within twenty business days after receipt...

  15. 46 CFR 199.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

  16. 46 CFR 199.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

  17. 46 CFR 199.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

  18. 46 CFR 199.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

  19. 46 CFR 199.145 - Marine evacuation system launching arrangements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Marine evacuation system launching arrangements. 199.145....145 Marine evacuation system launching arrangements. (a) Arrangements. Each marine evacuation system... from the marine evacuation system platform by a person either in the liferaft or on the platform; (4...

  20. 24 CFR 1720.145 - Disqualification of administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... may file with the administrative law judge a motion that the administrative law judge be disqualified... law judge. 1720.145 Section 1720.145 Housing and Urban Development Regulations Relating to Housing and... administrative law judge. (a) When an administrative law judge feels disqualified from presiding in a particular...

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