Sample records for elementary volume rev
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NASA Astrophysics Data System (ADS)
Wu, Ming; Wu, Jianfeng; Wu, Jichun
2017-10-01
When the dense nonaqueous phase liquid (DNAPL) comes into the subsurface environment, its migration behavior is crucially affected by the permeability and entry pressure of subsurface porous media. A prerequisite for accurately simulating DNAPL migration in aquifers is then the determination of the permeability, entry pressure and corresponding representative elementary volumes (REV) of porous media. However, the permeability, entry pressure and corresponding representative elementary volumes (REV) are hard to determine clearly. This study utilizes the light transmission micro-tomography (LTM) method to determine the permeability and entry pressure of two dimensional (2D) translucent porous media and integrates the LTM with a criterion of relative gradient error to quantify the corresponding REV of porous media. As a result, the DNAPL migration in porous media might be accurately simulated by discretizing the model at the REV dimension. To validate the quantification methods, an experiment of perchloroethylene (PCE) migration is conducted in a two-dimensional heterogeneous bench-scale aquifer cell. Based on the quantifications of permeability, entry pressure and REV scales of 2D porous media determined by the LTM and relative gradient error, different models with different sizes of discretization grid are used to simulate the PCE migration. It is shown that the model based on REV size agrees well with the experimental results over the entire migration period including calibration, verification and validation processes. This helps to better understand the microstructures of porous media and achieve accurately simulating DNAPL migration in aquifers based on the REV estimation.
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NASA Astrophysics Data System (ADS)
Wu, Ming; Cheng, Zhou; Wu, Jianfeng; Wu, Jichun
2017-06-01
Representative elementary volume (REV) is important to determine properties of porous media and those involved in migration of contaminants especially dense nonaqueous phase liquids (DNAPLs) in subsurface environment. In this study, an experiment of long-term migration of the commonly used DNAPL, perchloroethylene (PCE), is performed in a two dimensional (2D) sandbox where several system variables including porosity, PCE saturation (Soil) and PCE-water interfacial area (AOW) are accurately quantified by light transmission techniques over the entire PCE migration process. Moreover, the REVs for these system variables are estimated by a criterion of relative gradient error (εgi) and results indicate that the frequency of minimum porosity-REV size closely follows a Gaussian distribution in the range of 2.0 mm and 8.0 mm. As experiment proceeds in PCE infiltration process, the frequency and cumulative frequency of both minimum Soil-REV and minimum AOW-REV sizes change their shapes from the irregular and random to the regular and smooth. When experiment comes into redistribution process, the cumulative frequency of minimum Soil-REV size reveals a linear positive correlation, while frequency of minimum AOW-REV size tends to a Gaussian distribution in the range of 2.0 mm-7.0 mm and appears a peak value in 13.0 mm-14.0 mm. Undoubtedly, this study will facilitate the quantification of REVs for materials and fluid properties in a rapid, handy and economical manner, which helps enhance our understanding of porous media and DNAPL properties at micro scale, as well as the accuracy of DNAPL contamination modeling at field-scale.
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NASA Astrophysics Data System (ADS)
Georgiadis, A.; Berg, S.; Makurat, A.; Maitland, G.; Ott, H.
2013-09-01
We investigated the cluster-size distribution of the residual nonwetting phase in a sintered glass-bead porous medium at two-phase flow conditions, by means of micro-computed-tomography (μCT) imaging with pore-scale resolution. Cluster-size distribution functions and cluster volumes were obtained by image analysis for a range of injected pore volumes under both imbibition and drainage conditions; the field of view was larger than the porosity-based representative elementary volume (REV). We did not attempt to make a definition for a two-phase REV but used the nonwetting-phase cluster-size distribution as an indicator. Most of the nonwetting-phase total volume was found to be contained in clusters that were one to two orders of magnitude larger than the porosity-based REV. The largest observed clusters in fact ranged in volume from 65% to 99% of the entire nonwetting phase in the field of view. As a consequence, the largest clusters observed were statistically not represented and were found to be smaller than the estimated maximum cluster length. The results indicate that the two-phase REV is larger than the field of view attainable by μCT scanning, at a resolution which allows for the accurate determination of cluster connectivity.
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NASA Astrophysics Data System (ADS)
Bruns, S.; Stipp, S. L. S.; Sørensen, H. O.
2017-09-01
Digital rock physics carries the dogmatic concept of having to segment volume images for quantitative analysis but segmentation rejects huge amounts of signal information. Information that is essential for the analysis of difficult and marginally resolved samples, such as materials with very small features, is lost during segmentation. In X-ray nanotomography reconstructions of Hod chalk we observed partial volume voxels with an abundance that limits segmentation based analysis. Therefore, we investigated the suitability of greyscale analysis for establishing statistical representative elementary volumes (sREV) for the important petrophysical parameters of this type of chalk, namely porosity, specific surface area and diffusive tortuosity, by using volume images without segmenting the datasets. Instead, grey level intensities were transformed to a voxel level porosity estimate using a Gaussian mixture model. A simple model assumption was made that allowed formulating a two point correlation function for surface area estimates using Bayes' theory. The same assumption enables random walk simulations in the presence of severe partial volume effects. The established sREVs illustrate that in compacted chalk, these simulations cannot be performed in binary representations without increasing the resolution of the imaging system to a point where the spatial restrictions of the represented sample volume render the precision of the measurement unacceptable. We illustrate this by analyzing the origins of variance in the quantitative analysis of volume images, i.e. resolution dependence and intersample and intrasample variance. Although we cannot make any claims on the accuracy of the approach, eliminating the segmentation step from the analysis enables comparative studies with higher precision and repeatability.
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Vogel, J.R.; Brown, G.O.
2003-01-01
Semivariograms of samples of Culebra Dolomite have been determined at two different resolutions for gamma ray computed tomography images. By fitting models to semivariograms, small-scale and large-scale correlation lengths are determined for four samples. Different semivariogram parameters were found for adjacent cores at both resolutions. Relative elementary volume (REV) concepts are related to the stationarity of the sample. A scale disparity factor is defined and is used to determine sample size required for ergodic stationarity with a specified correlation length. This allows for comparison of geostatistical measures and representative elementary volumes. The modifiable areal unit problem is also addressed and used to determine resolution effects on correlation lengths. By changing resolution, a range of correlation lengths can be determined for the same sample. Comparison of voxel volume to the best-fit model correlation length of a single sample at different resolutions reveals a linear scaling effect. Using this relationship, the range of the point value semivariogram is determined. This is the range approached as the voxel size goes to zero. Finally, these results are compared to the regularization theory of point variables for borehole cores and are found to be a better fit for predicting the volume-averaged range.
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NASA Astrophysics Data System (ADS)
Shah, S.; Gray, F.; Yang, J.; Crawshaw, J.; Boek, E.
2016-12-01
Advances in 3D pore-scale imaging and computational methods have allowed an exceptionally detailed quantitative and qualitative analysis of the fluid flow in complex porous media. A fundamental problem in pore-scale imaging and modelling is how to represent and model the range of scales encountered in porous media, starting from the smallest pore spaces. In this study, a novel method is presented for determining the representative elementary volume (REV) of a rock for several parameters simultaneously. We calculate the two main macroscopic petrophysical parameters, porosity and single-phase permeability, using micro CT imaging and Lattice Boltzmann (LB) simulations for 14 different porous media, including sandpacks, sandstones and carbonates. The concept of the `Convex Hull' is then applied to calculate the REV for both parameters simultaneously using a plot of the area of the convex hull as a function of the sub-volume, capturing the different scales of heterogeneity from the pore-scale imaging. The results also show that the area of the convex hull (for well-chosen parameters such as the log of the permeability and the porosity) decays exponentially with sub-sample size suggesting a computationally efficient way to determine the system size needed to calculate the parameters to high accuracy (small convex hull area). Finally we propose using a characteristic length such as the pore size to choose an efficient absolute voxel size for the numerical rock.
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NASA Astrophysics Data System (ADS)
Saxena, Nishank; Hows, Amie; Hofmann, Ronny; Alpak, Faruk O.; Freeman, Justin; Hunter, Sander; Appel, Matthias
2018-06-01
This study defines the optimal operating envelope of the Digital Rock technology from the perspective of imaging and numerical simulations of transport properties. Imaging larger volumes of rocks for Digital Rock Physics (DRP) analysis improves the chances of achieving a Representative Elementary Volume (REV) at which flow-based simulations (1) do not vary with change in rock volume, and (2) is insensitive to the choice of boundary conditions. However, this often comes at the expense of image resolution. This trade-off exists due to the finiteness of current state-of-the-art imaging detectors. Imaging and analyzing digital rocks that sample the REV and still sufficiently resolve pore throats is critical to ensure simulation quality and robustness of rock property trends for further analysis. We find that at least 10 voxels are needed to sufficiently resolve pore throats for single phase fluid flow simulations. If this condition is not met, additional analyses and corrections may allow for meaningful comparisons between simulation results and laboratory measurements of permeability, but some cases may fall outside the current technical feasibility of DRP. On the other hand, we find that the ratio of field of view and effective grain size provides a reliable measure of the REV for siliciclastic rocks. If this ratio is greater than 5, the coefficient of variation for single-phase permeability simulations drops below 15%. These imaging considerations are crucial when comparing digitally computed rock flow properties with those measured in the laboratory. We find that the current imaging methods are sufficient to achieve both REV (with respect to numerical boundary conditions) and required image resolution to perform digital core analysis for coarse to fine-grained sandstones.
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NASA Astrophysics Data System (ADS)
Wang, Zhechao; Li, Wei; Bi, Liping; Qiao, Liping; Liu, Richeng; Liu, Jie
2018-05-01
A method to estimate the representative elementary volume (REV) size for the permeability and equivalent permeability coefficient of rock mass with a radial flow configuration was developed. The estimations of the REV size and equivalent permeability for the rock mass around an underground oil storage facility using a radial flow configuration were compared with those using a unidirectional flow configuration. The REV sizes estimated using the unidirectional flow configuration are much higher than those estimated using the radial flow configuration. The equivalent permeability coefficient estimated using the radial flow configuration is unique, while those estimated using the unidirectional flow configuration depend on the boundary conditions and flow directions. The influences of the fracture trace length, spacing and gap on the REV size and equivalent permeability coefficient were investigated. The REV size for the permeability of fractured rock mass increases with increasing the mean trace length and fracture spacing. The influence of the fracture gap length on the REV size is insignificant. The equivalent permeability coefficient decreases with the fracture spacing, while the influences of the fracture trace length and gap length are not determinate. The applicability of the proposed method to the prediction of groundwater inflow into rock caverns was verified using the measured groundwater inflow into the facility. The permeability coefficient estimated using the radial flow configuration is more similar to the representative equivalent permeability coefficient than those estimated with different boundary conditions using the unidirectional flow configuration.
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NASA Astrophysics Data System (ADS)
Song, Jie; Dong, Mei; Koltuk, Serdar; Hu, Hui; Zhang, Luqing; Azzam, Rafig
2018-05-01
Construction works associated with the building of reservoirs in mountain areas can damage the stability of adjacent valley slopes. Seepage processes caused by the filling and drawdown operations of reservoirs also affect the stability of the reservoir banks over time. The presented study investigates the stability of a fractured-rock slope subjected to seepage forces in the lower basin of a planned pumped-storage hydropower (PSH) plant in Blaubeuren, Germany. The investigation uses a hydro-mechanically coupled finite-element analyses. For this purpose, an equivalent continuum model is developed by using a representative elementary volume (REV) approach. To determine the minimum required REV size, a large number of discrete fracture networks are generated using Monte Carlo simulations. These analyses give a REV size of 28 × 28 m, which is sufficient to represent the equivalent hydraulic and mechanical properties of the investigated fractured-rock mass. The hydro-mechanically coupled analyses performed using this REV size show that the reservoir operations in the examined PSH plant have negligible effect on the adjacent valley slope.
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Numerical modelling of powder caking at REV scale by using DEM
NASA Astrophysics Data System (ADS)
Guessasma, Mohamed; Silva Tavares, Homayra; Afrassiabian, Zahra; Saleh, Khashayar
2017-06-01
This work deals with numerical simulation of powder caking process caused by capillary condensation phenomenon. Caking consists in unwanted agglomeration of powder particles. This process is often irreversible and not easy to predict. To reproduce mechanism involved by caking phenomenon we have used the Discrete Elements Method (DEM). In the present work, we mainly focus on the role of capillary condensation and subsequent liquid bridge formation within a granular medium exposed to fluctuations of ambient relative humidity. Such bridges cause an attractive force between particles, leading to the formation of a cake with intrinsic physicochemical and mechanical properties. By considering a Representative Elementary Volume (REV), the DEM is then performed by means of a MULTICOR-3D software tacking into account the properties of the cake (degree of saturation) in order to establish relationships between the microscopic parameters and the macroscopic behaviour (tensile strength).
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Assessing the utility of FIB-SEM images for shale digital rock physics
NASA Astrophysics Data System (ADS)
Kelly, Shaina; El-Sobky, Hesham; Torres-Verdín, Carlos; Balhoff, Matthew T.
2016-09-01
Shales and other unconventional or low permeability (tight) reservoirs house vast quantities of hydrocarbons, often demonstrate considerable water uptake, and are potential repositories for fluid sequestration. The pore-scale topology and fluid transport mechanisms within these nanoporous sedimentary rocks remain to be fully understood. Image-informed pore-scale models are useful tools for studying porous media: a debated question in shale pore-scale petrophysics is whether there is a representative elementary volume (REV) for shale models? Furthermore, if an REV exists, how does it differ among petrophysical properties? We obtain three dimensional (3D) models of the topology of microscale shale volumes from image analysis of focused ion beam-scanning electron microscope (FIB-SEM) image stacks and investigate the utility of these models as a potential REV for shale. The scope of data used in this work includes multiple local groups of neighboring FIB-SEM images of different microscale sizes, corresponding core-scale (milli- and centimeters) laboratory data, and, for comparison, series of two-dimensional (2D) cross sections from broad ion beam SEM images (BIB-SEM), which capture a larger microscale field of view than the FIB-SEM images; this array of data is larger than the majority of investigations with FIB-SEM-derived microscale models of shale. Properties such as porosity, organic matter content, and pore connectivity are extracted from each model. Assessments of permeability with single phase, pressure-driven flow simulations are performed in the connected pore space of the models using the lattice-Boltzmann method. Calculated petrophysical properties are compared to those of neighboring FIB-SEM images and to core-scale measurements of the sample associated with the FIB-SEM sites. Results indicate that FIB-SEM images below ∼5000 μm3 volume (the largest volume analyzed) are not a suitable REV for shale permeability and pore-scale networks; i.e. field of view is compromised at the expense of detailed, but often unconnected, nanopore morphology. Further, we find that it is necessary to acquire several local FIB-SEM or BIB-SEM images and correlate their extracted geometric properties to improve the likelihood of achieving representative values of porosity and organic matter volume. Our work indicates that FIB-SEM images of microscale volumes of shale are a qualitative tool for petrophysical and transport analysis. Finally, we offer alternatives for quantitative pore-scale assessments of shale.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Jabbari, M.; Hattel, J. H.; Jambhekar, V. A.
Evaporation of water from a ceramic layer is a key phenomenon in the drying process for the manufacturing of tape cast ceramics. This process contains mass, momentum and energy exchange between the porous medium and the free–flow region. In order to analyze such interaction processes, a Representative Elementary Volume (REV)–scale model concept is presented for coupling non–isothermal multi–phase compositional porous–media flow and single–phase compositional laminar free–flow. The preliminary results show the typical expected evaporation behaviour from a porous medium initially saturated with water, and its transport to the free–flow region according to the existent results from the literature.
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ERIC Educational Resources Information Center
Lohbeck, Annette; Nitkowski, Dennis; Petermann, Franz
2016-01-01
Background: Research on test anxiety of elementary school children has mainly focused on prevalence rates and gender differences. Less work has addressed predictors of test anxiety in elementary school children. According to the control-value theory developed by Pekrun ("Educ Psychol Rev" 18:315-341. doi: 10.1007/s10648-006-9029-9,…
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Is the permeability of naturally fractured rocks scale dependent?
NASA Astrophysics Data System (ADS)
Azizmohammadi, Siroos; Matthäi, Stephan K.
2017-09-01
The equivalent permeability, keq of stratified fractured porous rocks and its anisotropy is important for hydrocarbon reservoir engineering, groundwater hydrology, and subsurface contaminant transport. However, it is difficult to constrain this tensor property as it is strongly influenced by infrequent large fractures. Boreholes miss them and their directional sampling bias affects the collected geostatistical data. Samples taken at any scale smaller than that of interest truncate distributions and this bias leads to an incorrect characterization and property upscaling. To better understand this sampling problem, we have investigated a collection of outcrop-data-based Discrete Fracture and Matrix (DFM) models with mechanically constrained fracture aperture distributions, trying to establish a useful Representative Elementary Volume (REV). Finite-element analysis and flow-based upscaling have been used to determine keq eigenvalues and anisotropy. While our results indicate a convergence toward a scale-invariant keq REV with increasing sample size, keq magnitude can have multi-modal distributions. REV size relates to the length of dilated fracture segments as opposed to overall fracture length. Tensor orientation and degree of anisotropy also converge with sample size. However, the REV for keq anisotropy is larger than that for keq magnitude. Across scales, tensor orientation varies spatially, reflecting inhomogeneity of the fracture patterns. Inhomogeneity is particularly pronounced where the ambient stress selectively activates late- as opposed to early (through-going) fractures. While we cannot detect any increase of keq with sample size as postulated in some earlier studies, our results highlight a strong keq anisotropy that influences scale dependence.
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Numerical modelling of the flow in the resin infusion process on the REV scale: A feasibility study
DOE Office of Scientific and Technical Information (OSTI.GOV)
Jabbari, M.; Spangenberg, J.; Hattel, J. H.
2016-06-08
The resin infusion process (RIP) has developed as a low cost method for manufacturing large fibre reinforced plastic parts. However, the process still presents some challenges to industry with regards to reliability and repeatability, resulting in expensive and inefficient trial and error development. In this paper, we show the implementation of 2D numerical models for the RIP using the open source simulator DuMu{sup X}. The idea of this study is to present a model which accounts for the interfacial forces coming from the capillary pressure on the so-called representative elementary volume (REV) scale. The model is described in detail andmore » three different test cases — a constant and a tensorial permeability as well as a preform/Balsa domain — are investigated. The results show that the developed model is very applicable for the RIP for manufacturing of composite parts. The idea behind this study is to test the developed model for later use in a real application, in which the preform medium has numerous layers with different material properties.« less
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NASA Astrophysics Data System (ADS)
Talbot, C.; McClure, J. E.; Armstrong, R. T.; Mostaghimi, P.; Hu, Y.; Miller, C. T.
2017-12-01
Microscale experimental and computational methods can be used to evaluate fundamental microscale mechanisms and deduce macroscale constitutive relationships and parameter values. The link between the microscale and the macroscale is especially demanding, because technical issues arise regarding the necessary scale of the system needed for a meaningful set of macroscale measures to be insensitive to the size of the system, which is known as a representative elementary volume (REV). While the REV scale is routinely determined for single-phase flow in porous media, no systematic study of the scale of a REV for the comprehensive set of macroscale measures considered here has been reported in the literature. A comprehensive set of measures of the macroscale state is developed. We further develop and apply methods to predict the REV scale and quantify the uncertainty of the estimate for this set of macroscale quantities. We model the system state in terms of standard errors of macroscale quantities as a multivariate Gaussian process dependent on the size of the domain simulated. We determine predictive distributions of function values and a posterior distributions of weights using standard kernels, as well as a kernel constructed using relationships between physical quantities. For each kernel, we discuss the decay of the mean and covariance with increasing domain size, and use cross-validation to facilitate model selection. The procedure yields a model of the domain size needed to achieve a REV with quantifiable uncertainty. We present results in the context of multiphase fluid flow through a highly resolved realization of sandstone imaged using micro-CT. A 1440x1440x4320 section of the full 2520x2520x5280 imaged medium is simulated using the lattice-Boltzmann method. We compare the fidelity of the predictive model with results obtained by an analogous approach using polynomial regression.
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NASA Astrophysics Data System (ADS)
Chiogna, Gabriele; Bellin, Alberto
2013-05-01
The laboratory experiments of Gramling et al. (2002) showed that incomplete mixing at the pore scale exerts a significant impact on transport of reactive solutes and that assuming complete mixing leads to overestimation of product concentration in bimolecular reactions. Successively, several attempts have been made to model this experiment, either considering spatial segregation of the reactants, non-Fickian transport applying a Continuous Time Random Walk (CTRW) or an effective upscaled time-dependent kinetic reaction term. Previous analyses of these experimental results showed that, at the Darcy scale, conservative solute transport is well described by a standard advection dispersion equation, which assumes complete mixing at the pore scale. However, reactive transport is significantly affected by incomplete mixing at smaller scales, i.e., within a reference elementary volume (REV). We consider here the family of equilibrium reactions for which the concentration of the reactants and the product can be expressed as a function of the mixing ratio, the concentration of a fictitious non reactive solute. For this type of reactions we propose, in agreement with previous studies, to model the effect of incomplete mixing at scales smaller than the Darcy scale assuming that the mixing ratio is distributed within an REV according to a Beta distribution. We compute the parameters of the Beta model by imposing that the mean concentration is equal to the value that the concentration assumes at the continuum Darcy scale, while the variance decays with time as a power law. We show that our model reproduces the concentration profiles of the reaction product measured in the Gramling et al. (2002) experiments using the transport parameters obtained from conservative experiments and an instantaneous reaction kinetic. The results are obtained applying analytical solutions both for conservative and for reactive solute transport, thereby providing a method to handle the effect of incomplete mixing on multispecies reactive solute transport, which is simpler than other previously developed methods.
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NASA Astrophysics Data System (ADS)
Sheng, Guanglong; Su, Yuliang; Wang, Wendong; Javadpour, Farzam; Tang, Meirong
According to hydraulic-fracturing practices conducted in shale reservoirs, effective stimulated reservoir volume (ESRV) significantly affects the production of hydraulic fractured well. Therefore, estimating ESRV is an important prerequisite for confirming the success of hydraulic fracturing and predicting the production of hydraulic fracturing wells in shale reservoirs. However, ESRV calculation remains a longstanding challenge in hydraulic-fracturing operation. In considering fractal characteristics of the fracture network in stimulated reservoir volume (SRV), this paper introduces a fractal random-fracture-network algorithm for converting the microseismic data into fractal geometry. Five key parameters, including bifurcation direction, generating length (d), deviation angle (α), iteration times (N) and generating rules, are proposed to quantitatively characterize fracture geometry. Furthermore, we introduce an orthogonal-fractures coupled dual-porosity-media representation elementary volume (REV) flow model to predict the volumetric flux of gas in shale reservoirs. On the basis of the migration of adsorbed gas in porous kerogen of REV with different fracture spaces, an ESRV criterion for shale reservoirs with SRV is proposed. Eventually, combining the ESRV criterion and fractal characteristic of a fracture network, we propose a new approach for evaluating ESRV in shale reservoirs. The approach has been used in the Eagle Ford shale gas reservoir, and results show that the fracture space has a measurable influence on migration of adsorbed gas. The fracture network can contribute to enhancement of the absorbed gas recovery ratio when the fracture space is less than 0.2 m. ESRV is evaluated in this paper, and results indicate that the ESRV accounts for 27.87% of the total SRV in shale gas reservoirs. This work is important and timely for evaluating fracturing effect and predicting production of hydraulic fracturing wells in shale reservoirs.
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Multiscale pore structure and constitutive models of fine-grained rocks
NASA Astrophysics Data System (ADS)
Heath, J. E.; Dewers, T. A.; Shields, E. A.; Yoon, H.; Milliken, K. L.
2017-12-01
A foundational concept of continuum poromechanics is the representative elementary volume or REV: an amount of material large enough that pore- or grain-scale fluctuations in relevant properties are dissipated to a definable mean, but smaller than length scales of heterogeneity. We determine 2D-equivalent representative elementary areas (REAs) of pore areal fraction of three major types of mudrocks by applying multi-beam scanning electron microscopy (mSEM) to obtain terapixel image mosaics. Image analysis obtains pore areal fraction and pore size and shape as a function of progressively larger measurement areas. Using backscattering imaging and mSEM data, pores are identified by the components within which they occur, such as in organics or the clastic matrix. We correlate pore areal fraction with nano-indentation, micropillar compression, and axysimmetic testing at multiple length scales on a terrigenous-argillaceous mudrock sample. The combined data set is used to: investigate representative elementary volumes (and areas for the 2D images); determine if scale separation occurs; and determine if transport and mechanical properties at a given length scale can be statistically defined. Clear scale separation occurs between REAs and observable heterogeneity in two of the samples. A highly-laminated sample exhibits fine-scale heterogeneity and an overlapping in scales, in which case typical continuum assumptions on statistical variability may break down. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia LLC, a wholly owned subsidiary of Honeywell International Inc. for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.
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NASA Astrophysics Data System (ADS)
Islam, Amina; Chevalier, Sylvie; Sassi, Mohamed
2018-04-01
With advances in imaging techniques and computational power, Digital Rock Physics (DRP) is becoming an increasingly popular tool to characterize reservoir samples and determine their internal structure and flow properties. In this work, we present the details for imaging, segmentation, as well as numerical simulation of single-phase flow through a standard homogenous Silurian dolomite core plug sample as well as a heterogeneous sample from a carbonate reservoir. We develop a procedure that integrates experimental results into the segmentation step to calibrate the porosity. We also look into using two different numerical tools for the simulation; namely Avizo Fire Xlab Hydro that solves the Stokes' equations via the finite volume method and Palabos that solves the same equations using the Lattice Boltzmann Method. Representative Elementary Volume (REV) and isotropy studies are conducted on the two samples and we show how DRP can be a useful tool to characterize rock properties that are time consuming and costly to obtain experimentally.
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ERIC Educational Resources Information Center
Keaton, Patrick
2012-01-01
The Public Elementary/Secondary School Universe file includes data for the following variables: NCES school ID number, state school ID number, name of the school, name of the agency that operates the school, mailing address, physical location address, phone number, school type, operational status, locale code, latitude, longitude, county number,…
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Adaptive clustering procedure for continuous gravitational wave searches
NASA Astrophysics Data System (ADS)
Singh, Avneet; Papa, Maria Alessandra; Eggenstein, Heinz-Bernd; Walsh, Sinéad
2017-10-01
In hierarchical searches for continuous gravitational waves, clustering of candidates is an important post-processing step because it reduces the number of noise candidates that are followed up at successive stages [J. Aasi et al., Phys. Rev. Lett. 88, 102002 (2013), 10.1103/PhysRevD.88.102002; B. Behnke, M. A. Papa, and R. Prix, Phys. Rev. D 91, 064007 (2015), 10.1103/PhysRevD.91.064007; M. A. Papa et al., Phys. Rev. D 94, 122006 (2016), 10.1103/PhysRevD.94.122006]. Previous clustering procedures bundled together nearby candidates ascribing them to the same root cause (be it a signal or a disturbance), based on a predefined cluster volume. In this paper, we present a procedure that adapts the cluster volume to the data itself and checks for consistency of such volume with what is expected from a signal. This significantly improves the noise rejection capabilities at fixed detection threshold, and at fixed computing resources for the follow-up stages, this results in an overall more sensitive search. This new procedure was employed in the first Einstein@Home search on data from the first science run of the advanced LIGO detectors (O1) [LIGO Scientific Collaboration and Virgo Collaboration, arXiv:1707.02669 [Phys. Rev. D (to be published)
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Estimation of Length-Scales in Soils by MRI
NASA Technical Reports Server (NTRS)
Daidzic, N. E.; Altobelli, S.; Alexander, J. I. D.
2004-01-01
Soil can be best described as an unconsolidated granular media that forms porous structure. The present macroscopic theory of water transport in porous media rests upon the continuum hypothesis that the physical properties of porous media can be associated with continuous, twice-differentiable field variables whose spatial domain is a set of centroids of Representative Elementary Volume (REV) elements. MRI is an ideal technique to estimate various length-scales in porous media. A 0.267 T permanent magnet at NASA GRC was used for this study. A 2D or 3D spatially-resolved porosity distribution were obtained from the NMR signal strength from each voxel and the spin-lattice relaxation time. A classical spin-warp imaging with Multiple Spin Echos (MSE) was used to evaluate proton density in each voxel. Initial resolution of 256 x 256 was subsequently reduced by averaging neighboring voxels and the porosity convergence was observed. A number of engineered "space candidate" soils such as Isolite(trademark), Zeoponics(trademark), Turface(trademark), and Profile(trademark) were used. Glass beads in the size range between 50 microns to 2 mm were used as well. Initial results with saturated porous samples have shown a good estimate of the average porosity consistent with the gravimetric porosity measurement results. For Profile(trademark) samples with particle sizes ranging between 0.25 to 1 mm and characteristic interparticle pore size of 100 microns the characteristic Darcy scale was estimated to be about delta(sub REV) = 10 mm. Glass beads porosity show clear convergence toward a definite REV which stays constant throughout homogeneous sample. Additional information is included in the original extended abstract.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Eslinger, Paul W.; Aaberg, Rosanne L.; Lopresti, Charles A.
2004-09-14
This document contains detailed user instructions for a suite of utility codes developed for Rev. 1 of the Systems Assessment Capability. The suite of computer codes for Rev. 1 of Systems Assessment Capability performs many functions.
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NASA Astrophysics Data System (ADS)
Milani, Marco; Germán Rubino, J.; Müller, Tobias M.; Quintal, Beatriz; Holliger, Klaus
2014-05-01
Fractures are present in most geological formations and they tend to dominate not only their mechanical but also, and in particular, their hydraulic properties. For these reasons, the detection and characterization of fractures are of great interest in several fields of Earth sciences. Seismic attenuation has been recognized as a key attribute for this purpose, as both laboratory and field experiments indicate that the presence of fractures typically produces significant energy dissipation and that this attribute tends to increase with increasing fracture density. This energy loss is generally considered to be primarily due to wave-induced pressure diffusion between the fractures and the embedding porous matrix. That is, due to the strong compressibility contrast between these two domains, the propagation of seismic waves can generate a strong fluid pressure gradient and associated pressure diffusion, which leads to fluid flow and in turn results in frictional energy dissipation. Numerical simulations based on Biot's poroelastic wave equations are computationally very expensive. Alternative approaches consist in performing numerical relaxation or creep tests on representative elementary volumes (REV) of the considered medium. These tests are typically based on Biot's consolidation equations. Assuming that the heterogeneous poroelastic medium can be replaced by an effective, homogeneous viscoelastic solid, these numerical creep and relaxation tests allow for computing the equivalent seismic P-wave attenuation and phase velocity. From a practical point of view, an REV is typically characterized by the smallest volume for which rock physical properties are statistically stationary and representative of the probed medium in its entirety. A more general definition in the context of wavefield attributes is to consider an REV as the smallest volume over which the P-wave attenuation and phase velocity dispersion are independent of the applied boundary conditions. That is, the corresponding results obtained from creep and relaxation tests must be equivalent. For most analyses of media characterized by patchy saturation or double-porosity-type structures these two definitions are equivalent. It is, however, not clear whether this equivalence remains true in the presence of strong material contrasts as those prevailing in fractured rocks. In this work, we explore this question for periodically fractured media. To this end, we build a medium composed of infinite replicas of a unit volume containing one fracture. This unit volume coincides with the smallest possible volume that is statistically representative of the whole. Then, we perform several creep and relaxation tests on samples composed of an increasing number of these unit volumes. We find that the wave field signatures determined from relaxation tests are independent from the number of unit volumes. Conversely, the P-wave attenuation and phase velocity characteristics inferred from creep tests are different and vary with the number of unit volumes considered. Quite interestingly, the creep test results converge with those of the relaxation tests as the number of unit volumes increases. These findings are expected to have direct implications for corresponding laboratory measurements as well as for our understanding of seismic wave propagation in fractured media.
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Isotope effect in acetylene C2H2 and C2D2 rotations on Cu(001)
NASA Astrophysics Data System (ADS)
Shchadilova, Yulia E.; Tikhodeev, Sergei G.; Paulsson, Magnus; Ueba, Hiromu
2014-04-01
A comprehensive analysis of the elementary processes behind the scanning tunneling microscope controlled rotation of C2H2 and C2D2, isotopologues of a single acetylene molecule adsorbed on the Cu(001) surface, is given, with a focus on the isotope effects. With the help of density-functional theory we calculate the vibrational modes of C2H2 and C2D2 on Cu(001) and estimate the anharmonic couplings between them, using a simple strings-on-rods model. The probability of the elementary processes, nonlinear and combination band, is estimated using the Keldysh diagram technique. This allows us to clarify the main peculiarities and the isotope effects of the C2H2 and C2D2 on Cu(001) rotation, discovered in the pioneering work [B. C. Stipe et al., Phys. Rev. Lett. 81, 1263 (1998), 10.1103/PhysRevLett.81.1263], which have not been previously understood.
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NASA Astrophysics Data System (ADS)
Shpotyuk, Ya; Cebulski, J.; Ingram, A.; Shpotyuk, O.
2017-12-01
Methodological possibilities of positron annihilation lifetime (PAL) spectroscopy in application to nanostructurized substances treated within three-term fitting procedure are reconsidered to parameterize their atomic-deficient structural arrangement. In contrast to conventional three-term fitting analysis of the detected PAL spectra based on admixed positron trapping and positronium (Ps) decaying, the nanostructurization due to guest nanoparticles embedded in host matrix is considered as producing modified trapping, which involves conversion between these channels. The developed approach referred to as x3-x2-coupling decomposition algorithm allows estimation free volumes of interfacial voids responsible for positron trapping and bulk lifetimes in nanoparticle-embedded substances. This methodology is validated using experimental data of Chakraverty et al. [Phys. Rev. B71 (2005) 024115] on PAL study of composites formed by guest NiFe2O4 nanocrystals grown in host SiO2 matrix.
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Vassal, J-P; Orgéas, L; Favier, D; Auriault, J-L; Le Corre, S
2008-01-01
In paper I [Vassal, Phys. Rev. E77, 011302 (2008)] of this contribution, the effective diffusion properties of particulate media with highly conductive particles and particle-particle interfacial barriers have been investigated with the homogenization method with multiple scale asymptotic expansions. Three different macroscopic models have been proposed depending on the quality of contacts between particles. However, depending on the nature and the geometry of particles contained in representative elementary volumes of the considered media, localization problems to be solved to compute the effective conductivity of the two first models can rapidly become cumbersome, time and memory consuming. In this second paper, the above problem is simplified and applied to networks made of slender, wavy and entangled fibers. For these types of media, discrete formulations of localization problems for all macroscopic models can be obtained leading to very efficient numerical calculations. Semianalytical expressions of the effective conductivity tensors are also proposed under simplifying assumptions. The case of straight monodisperse and homogeneously distributed slender fibers with a circular cross section is further explored. Compact semianalytical and analytical estimations are obtained when fiber-fiber contacts are perfect or very poor. Moreover, two discrete element codes have been developed and used to solve localization problems on representative elementary volumes for the same types of contacts. Numerical results underline the significant roles of the fiber content, the orientation of fibers as well as the relative position and orientation of contacting fibers on the effective conductivity tensors. Semianalytical and analytical predictions are discussed and compared with numerical results.
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NASA Astrophysics Data System (ADS)
Shah, S. M.; Crawshaw, J. P.; Gray, F.; Yang, J.; Boek, E. S.
2017-06-01
In the last decade, the study of fluid flow in porous media has developed considerably due to the combination of X-ray Micro Computed Tomography (micro-CT) and advances in computational methods for solving complex fluid flow equations directly or indirectly on reconstructed three-dimensional pore space images. In this study, we calculate porosity and single phase permeability using micro-CT imaging and Lattice Boltzmann (LB) simulations for 8 different porous media: beadpacks (with bead sizes 50 μm and 350 μm), sandpacks (LV60 and HST95), sandstones (Berea, Clashach and Doddington) and a carbonate (Ketton). Combining the observed porosity and calculated single phase permeability, we shed new light on the existence and size of the Representative Element of Volume (REV) capturing the different scales of heterogeneity from the pore-scale imaging. Our study applies the concept of the 'Convex Hull' to calculate the REV by considering the two main macroscopic petrophysical parameters, porosity and single phase permeability, simultaneously. The shape of the hull can be used to identify strong correlation between the parameters or greatly differing convergence rates. To further enhance computational efficiency we note that the area of the convex hull (for well-chosen parameters such as the log of the permeability and the porosity) decays exponentially with sub-sample size so that only a few small simulations are needed to determine the system size needed to calculate the parameters to high accuracy (small convex hull area). Finally we propose using a characteristic length such as the pore size to choose an efficient absolute voxel size for the numerical rock.
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Bibliography of Leishmania and Leishmanial Diseases. Volume 1
1980-06-01
Sea 7 Rev. Med.- Yucatan Paulo, REVISTA MEDICA DE YUCATAN . Merida. Rev, Paliclin, Caracas Rev. Menn. Med. , Brazil REVISTA DE LA POLICLINICA, CARACAc...Parasit., 41(2):126-136. 799 pp. CHAKG, P. Y.; TENG, L. T.; SUNG, Y. (1957A) Interactions T. & LIU, Y. C. (1958A) Kala-azar between nutrition and...of nutrition in experimental Infectivan. Bact. Rev. , 13:99-134. CLINTON, B. A.; STAUBER, L. A.& CLRT .(1959A) Comparative PALCZUK, N. C. (1969A
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NASA Astrophysics Data System (ADS)
Bilheux, Hassina; Liu, Yuan; Alton, Gerald; Cole, John; Williams, Cecil; Reed, Charles
2004-11-01
Performance of ECR ion sources can be significantly enhanced by increasing the physical size of their ECR zones in relation to the size of their plasma volumes (spatial and frequency domain methods).^3-5 A 6 GHz, all-permanent magnet ECR ion source with a large resonant plasma volume has been tested at ORNL.^6 The magnetic circuit can be configured for creating both flat-β (volume) and conventional minimum-β (surface) resonance conditions. Direct comparisons of the performance of the two source types can be made under similar operating conditions. In this paper, we clearly demonstrate that the flat-β source outperforms its minimum-β counterpart in terms of charge state distribution and intensity within a particular charge state. ^1bilheuxhn@ornl.gov ^2Managed by UT-Battelle, LLC, for the U.S. Department of Energy under contract DE-AC05-00OR22725. ^3G.D. Alton, D.N. Smithe, Rev. Sci. Instrum. 65 (1994) 775. ^4G.D. Alton et al., Rev. Sci. Instrum. 69 (1998) 2305. ^5Z.Q. Xie, C.M. Lyneis, Rev. Sci. Instrum. 66 (1995) 4218. ^6Y. Liu et al., Rev. Sci. Instrum. 69 (1998) 1311.
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DOT National Transportation Integrated Search
1981-03-30
This report (Volume 2 of four volumes) serves as a users guide for elementary schools implementing the PEDSAFE Program. Volume 1 of this report describes the conduct and results of the evaluation of the entire PEDSAFE Program and provides recommendat...
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Statistical Inference for Porous Materials using Persistent Homology.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Moon, Chul; Heath, Jason E.; Mitchell, Scott A.
2017-12-01
We propose a porous materials analysis pipeline using persistent homology. We rst compute persistent homology of binarized 3D images of sampled material subvolumes. For each image we compute sets of homology intervals, which are represented as summary graphics called persistence diagrams. We convert persistence diagrams into image vectors in order to analyze the similarity of the homology of the material images using the mature tools for image analysis. Each image is treated as a vector and we compute its principal components to extract features. We t a statistical model using the loadings of principal components to estimate material porosity, permeability,more » anisotropy, and tortuosity. We also propose an adaptive version of the structural similarity index (SSIM), a similarity metric for images, as a measure to determine the statistical representative elementary volumes (sREV) for persistence homology. Thus we provide a capability for making a statistical inference of the uid ow and transport properties of porous materials based on their geometry and connectivity.« less
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The Condition of Education, 1990. Volume 1: Elementary and Secondary Education.
ERIC Educational Resources Information Center
Ogle, Laurence T., Ed.; Alsalam, Nabeel, Ed.
This is the first of two volumes of the National Center for Education Statistics' annual statistical report on the condition of education in the United States for 1990. This volume addresses elementary and secondary education, while the second volume covers postsecondary education (PE). Condition of education indicators (CEIs)--key data that…
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ERIC Educational Resources Information Center
Catholic Education: A Journal of Inquiry and Practice, 2008
2008-01-01
In June 2005, shortly before Rev. John I. Jenkins, CSC, became president of the University of Notre Dame, the United States Conference of Catholic Bishops released a pastoral statement, "Renewing Our Commitment to Catholic Elementary and Secondary Schools in the Third Millennium." This document, building upon the rich experience of two…
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Martiniani, Stefano; Schrenk, K Julian; Stevenson, Jacob D; Wales, David J; Frenkel, Daan
2016-01-01
We present a numerical calculation of the total number of disordered jammed configurations Ω of N repulsive, three-dimensional spheres in a fixed volume V. To make these calculations tractable, we increase the computational efficiency of the approach of Xu et al. [Phys. Rev. Lett. 106, 245502 (2011)10.1103/PhysRevLett.106.245502] and Asenjo et al. [Phys. Rev. Lett. 112, 098002 (2014)10.1103/PhysRevLett.112.098002] and we extend the method to allow computation of the configurational entropy as a function of pressure. The approach that we use computes the configurational entropy by sampling the absolute volume of basins of attraction of the stable packings in the potential energy landscape. We find a surprisingly strong correlation between the pressure of a configuration and the volume of its basin of attraction in the potential energy landscape. This relation is well described by a power law. Our methodology to compute the number of minima in the potential energy landscape should be applicable to a wide range of other enumeration problems in statistical physics, string theory, cosmology, and machine learning that aim to find the distribution of the extrema of a scalar cost function that depends on many degrees of freedom.
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Elementary Career Education Guide, Volume 2: Career Awareness--Primary.
ERIC Educational Resources Information Center
Watertown Independent School District 1, SD.
Volume 2 of the six-volume articulated elementary education career guide deals with the career awareness level of career education and aims at developing student career identity. The lessons in the volume are divided and color-coded by grade level (early childhood, primary levels one, two, and three corresponding respectively with grades K-three,…
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LEARN JAPANESE--ELEMENTARY SCHOOL TEXT, VOLUME II.
ERIC Educational Resources Information Center
SATO, YAEKO; AND OTHERS
THIS TEXT WAS WRITTEN FOR THE USE OF THE ELEMENTARY SCHOOL TEACHER OF JAPANESE. IT IS TO BE USED IN THE SECOND SEMESTER OF JAPANESE LANGUAGE STUDY AND FOLLOWS THE AUDIO-LINGUAL ORIENTATION OF VOLUME I. THE MAIN GOAL OF BOTH VOLUMES IS "TO ELEVATE THE PUPIL'S MOTIVATION AND TO CULTIVATE PROPER PRONUNCIATION HABITS." THE NEW ITEMS IN VOLUME II…
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BFACF-style algorithms for polygons in the body-centered and face-centered cubic lattices
NASA Astrophysics Data System (ADS)
Janse van Rensburg, E. J.; Rechnitzer, A.
2011-04-01
In this paper, the elementary moves of the BFACF-algorithm (Aragão de Carvalho and Caracciolo 1983 Phys. Rev. B 27 1635-45, Aragão de Carvalho and Caracciolo 1983 Nucl. Phys. B 215 209-48, Berg and Foester 1981 Phys. Lett. B 106 323-6) for lattice polygons are generalized to elementary moves of BFACF-style algorithms for lattice polygons in the body-centered (BCC) and face-centered (FCC) cubic lattices. We prove that the ergodicity classes of these new elementary moves coincide with the knot types of unrooted polygons in the BCC and FCC lattices and so expand a similar result for the cubic lattice (see Janse van Rensburg and Whittington (1991 J. Phys. A: Math. Gen. 24 5553-67)). Implementations of these algorithms for knotted polygons using the GAS algorithm produce estimates of the minimal length of knotted polygons in the BCC and FCC lattices.
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ERIC Educational Resources Information Center
Baxter, G. P.; Ahmed, S.; Sikali, E.; Waits, T.; Sloan, M.; Salvucci, S.
2007-01-01
The Nation's Report Card[TM] informs the public about the academic achievement of elementary and secondary students in the United States and its jurisdictions, including Puerto Rico. In 2003, a trial NAEP mathematics assessment was administered in Spanish to public school students at grades 4 and 8 in Puerto Rico. Based on preliminary analyses of…
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Wisconsin Elementary Teacher Education Project. Volumes I-IV.
ERIC Educational Resources Information Center
Kean, John M., Ed.
This four-volume report includes position papers and specifications for the elementary teacher education program of the University of Wisconsin in the year 1975 and beyond. Volume 1 includes a series of 12 position papers which cover topics ranging from teacher roles and systems approaches to instruction to control and management procedures for…
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It's Elementary: Special Topics in Elementary Education.
ERIC Educational Resources Information Center
Crawford, Patricia A., Ed.; Burriss, Kathleen Glascott, Ed.
As elementary teachers work to educate and meet the needs of the students in their care, their job has become increasingly challenging and demanding. This volume addresses a variety of issues and topics related to elementary education around eight sectional themes relevant to the work of elementary teachers: celebrating diversity, classroom…
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Learning and Teaching Elementary Subjects. Advances in Research on Teaching. Volume 5.
ERIC Educational Resources Information Center
Brophy, Jere, Ed.
This publication is the fifth volume in the "Advanced in Research on Teaching" series, which has been established to provide state-of-the-art conceptualization and analysis of the processes involved in functioning as a classroom teacher. This volume focuses on the work of the Center for the Learning and Teaching of Elementary Subjects in…
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ERIC Educational Resources Information Center
Jim Rupp, Ed.
1994-01-01
Four issues of the newsletter of the Elementary Education Interest Section (EEIS) of Teachers of English to Speakers of Other Languages (TESOL) are presented in this document. Issue number 1 of volume 15, focussed on defining "who we are," describes the nature and purposes of EEIS and contains brief accounts by parents, students, and colleagues…
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Physics of the spin gap in the S=1/2 Heisenberg antiferromagnet on kagome
NASA Astrophysics Data System (ADS)
Tchernyshyov, Oleg
2009-03-01
A combination of low spin and strong frustration makes the S=1/2 Heisenberg antiferromagnet on kagome a likely candidate for an unusual ground state and elementary excitations. Exact-diagonalization studies [1] on finite clusters point to a lack of magnetic order in the ground state and to an energy gap of order J/20 for S=1 excitations. The exact nature of the ground state and elementary excitations remains a subject of vigorous debate. Among the proposed ground states are chiral [2] and non-chiral [3] spin liquids and a valence-bond crystal (VBC) [4-5]; spin excitations range from deconfined spinons with a Bose [6] or Fermi statistics [2-3] to magnons [7]. We show that the system behaves as a collection of spinons, quasiparticles with S=1/2 and Fermi statistics, whose motion disturbs valence-bond order. Attraction between spinons, mediated by exchange, binds them into small, massive pairs of S=0 with a binding energy of 0.06 J [8]. The pair formation strongly suppresses the motion of individual spinons and makes the survival of the Singh-Huse VBC plausible. A spin excitation amounts to breaking up a pair into two (nearly) free spinons with S=1. The survival of the VBC is expected to lead to spinon confinement; however, small energy differences between various valence-bond configurations would make the confinement length large. [4pt] [1] Ch. Waldtmann et al., Eur. Phys. J. B 2, 510 (1998).[0pt] [2] J. B. Marston and C. Zeng, J. Appl. Phys. 69, 5962 (1991).[0pt] [3] M. B. Hastings, Phys. Rev. B 63, 014413 (2000).[0pt] [4] P. Nikolic and T. Senthil, Phys. Rev. B 68, 214415 (2003).[0pt] [5] R. R. P. Singh and D. A. Huse, Phys. Rev. B 76, 180407 (2007).[0pt] [6] S. Sachdev, Phys. Rev. B 45, 12377 (1992).[0pt] [7] R. R. P. Singh and D. A. Huse, arXiv:0801.2735. [0pt] [8] Z. Hao and O. Tchernyshyov, the subsequent talk.
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Mutagenicity of airborne particulates in the rubber industry.
Barański, B; Indulski, J; Janik-Spiechowicz, E; Palus, J
1989-12-01
The aim of this work was to evaluate the mutagenic activity of airborne particulate matter in the rubber industry. Air was sucked through Whatman glass-fibre filters with Staplex pumps and adsorbed substances and fume particles were extracted with acetone or toluene for 2 h in a ultrasonic cleaner. After separation of the insoluble solid phase by filtration, solvent was evaporated at a temperature of 70 degrees C in an argon atmosphere. The residue was stored at -20 degrees C. Mutagenicity was determined by the Salmonella plate incorporation assay with the tester strain TA98 and activity is related either to the weight of aerosol (rev mg-1) or to the volume of atmospheric sample (rev m-3). The fumes emitted from the tyre tread line, calender feeding, and tyre vulcanizing processes, showed the highest mutagenic activity (55-211 rev mg-1, + S9). At these and at other workplaces (extruder mill, carbon black station, mixer loading), mutagenic activity related to the volume of air was in the range of 22-158 rev m-3, + S9. The results indicate the need to reduce and monitor mutagenic contamination in order to increase the safety of work in the rubber industry.
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ERIC Educational Resources Information Center
Chen, Chen-Su; Sable, Jennifer; Mitchell, Lindsey; Liu, Fei
2012-01-01
The Common Core of Data (CCD) nonfiscal surveys consist of data submitted annually to the National Center for Education Statistics (NCES) by state education agencies (SEAs) in the 50 states, the District of Columbia, Puerto Rico, the four U.S. Island Areas (American Samoa, Guam, the Commonwealth of the Northern Mariana Islands, and the U.S. Virgin…
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ERIC Educational Resources Information Center
Schalock, H. Del, Ed.; Hale, James R., Ed.
This main volume (SP 002 155-SP 002 180 comprise the appendixes to this volume) explains the ComField (competency based, field centered) Model--a systems approach to the education of elementary school teachers which entails specifications (1) for instruction and (2) for management of the instructional program. In an overview, the ComField Model is…
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NASA Astrophysics Data System (ADS)
Swallows, M. D.; Loftus, T. H.; Griffith, W. C.; Heckel, B. R.; Fortson, E. N.; Romalis, M. V.
2013-01-01
We discuss in detail the search for a permanent electric dipole moment (EDM) of the 199Hg atom reported by Griffith [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.102.101601 102, 101601 (2009)]. The upper bound, d(199Hg)<3.1×10-29 e cm (95% C.L.), is a factor of 7 improvement over the best previous EDM limit for 199Hg, provides the most sensitive probe to date for EDMs in diamagnetic atoms, and sets new limits on time-reversal symmetry violation in extensions to the standard model. This paper provides extensive discussion of the techniques used to search for the 199Hg EDM and the implications of the new 199Hg EDM limit for CP violation in elementary particle interactions.
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NASA Astrophysics Data System (ADS)
Bojowald, Martin
The universe, ultimately, is to be described by quantum theory. Quantum aspects of all there is, including space and time, may not be significant for many purposes, but are crucial for some. And so a quantum description of cosmology is required for a complete and consistent worldview. At any rate, even if we were not directly interested in regimes where quantum cosmology plays a role, a complete physical description could not stop at a stage before the whole universe is reached. Quantum theory is essential in the microphysics of particles, atoms, molecules, solids, white dwarfs and neutron stars. Why should one expect this ladder of scales to end at a certain size? If regimes are sufficiently violent and energetic, quantum effects are non-negligible even on scales of the whole cosmos; this is realized at least once in the history of the universe: at the big bang where the classical theory of general relativity would make energy densities diverge.
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Phys. 21 111 2493114 1167.81025 10.1142/S0129055X09003591 Bojowald, M., Sandhöfer, B., Skirzewski, A., Tsobanjan, A.: Rev. Math. Phys. 21, 111 (2009), arXiv:0804.3365 28. JJ Halliwell SW Hawking 1985 Phys. Rev. D 31 8 1777 787748 1985PhRvD..31.1777H 10.1103/PhysRevD.31.1777 Halliwell, J.J., Hawking, S.W.: Phys. Rev. D 31(8), 1777 (1985) 29. PD D'Eath 2005 Supersymmetric Quantum Cosmology Cambridge University Press Cambridge D'Eath, P.D.: Supersymmetric Quantum Cosmology. Cambridge University Press, Cambridge (2005) 30. PV Moniz 2010 Quantum Cosmology - The Supersymmetric Perspective Springer Berlin Moniz, P.V.: Quantum Cosmology—The Supersymmetric Perspective. Springer, Berlin(2010) 31. PD D'Eath JJ Halliwell 1987 Phys. Rev. D 35 1100 878526 1987PhRvD..35.1100D 10.1103/PhysRevD.35.1100 D'Eath, P.D., Halliwell, J.J.: Phys. Rev. D 35, 1100 (1987) 32. T Gold 1962 Am. J. Phys. 30 403 1962AmJPh..30..403G 0105.22501 10.1119/1.1942052 Gold, T.: Am. J. Phys. 30, 403 (1962) 33. SW Hawking 1985 Phys. Rev. D 32 2489 811402 1985PhRvD..32.2489H 10.1103/PhysRevD.32.2489 Hawking, S.W.: Phys. Rev. D 32, 2489 (1985) 24. DN Page 1985 Phys. Rev. D 32 2496 811403 1985PhRvD..32.2496P 10.1103/PhysRevD.32.2496 Page, D.N.: Phys. Rev. D 32, 2496 (1985) 35. B Carr 2007 Universe or Multiverse? Cambridge University Press Cambridge Carr, B.(ed.): Universe or Multiverse? Cambridge University Press, Cambridge (2007) 1. D. Giulini C Kiefer E. Joos J Kupsch I.O. Stamatescu H.D. Zeh 1996 Decoherence and the Appearance of a Classical World in Quantum Theory Springer Berlin 0855.00003 10.1007/978-3-662-03263-3 Giulini, D., Kiefer, C., Joos, E., Kupsch, J., Stamatescu, I.O., Zeh, H.D.: Decoherence and the Appearance of a Classical World in Quantum Theory. Springer, Berlin (1996) 2. Bojowald, M., Brizuela, D., Hernandez, H.H., Koop, M.J., Morales-Técotl, H.A.:arXiv:1011.3022 3. J.P. Gazeau J. Klauder 1999 J. Phys. A: Math. Gen. 32 123 1668576 1999JPhA...32..123G 0919.47061 10.1088/0305-4470/32/1/013 arXiv:1011.3022 Gazeau, J.P., Klauder, J.: J. Phys. A: Math. Gen. 32, 123 (1999) 4. M. Novello S.E.P. Bergliaffa 2008 Phys. Rep. 463 127 2437050 2008PhR...463..127N 10.1016/j.physrep.2008.04.006 Novello, M., Bergliaffa, S.E.P.: Phys. Rep. 463, 127 (2008) 5. M. Bojowald 2010 Canonical Gravity and Applications: Cosmology, Black Holes, and Quantum Gravity Cambridge University Press Cambridge 10.1017/CBO9780511921759 Bojowald, M.: Canonical Gravity and Applications: Cosmology, Black Holes, and Quantum Gravity. Cambridge University Press, Cambridge (2010) 6. A. Ashtekar 1987 Phys. Rev. D 36 6 1587 909667 1987PhRvD..36.1587A 10.1103/PhysRevD.36.1587 Ashtekar, A.: Phys. Rev. D 36(6), 1587 (1987) 7. Barbero G.J.F., (1995) Phys. Rev. D 51(10): 5507 8. G. Immirzi 1997 Class. Quantum Grav. 14 L 177 1476539 1997CQGra..14L.177I 10.1088/0264-9381/14/10/002 Immirzi, G.: Class. Quantum Grav. 14, L 177 (1997) 9. J. Lewandowski E.T. Newman C. Rovelli 1993 J. Math. Phys. 34 4646 1235963 1993JMP....34.4646L 0790.53057 10.1063/1.530362 Lewandowski, J., Newman, E.T., Rovelli, C.: J. Math. Phys. 34, 4646 (1993) 10. C. Rovelli L. Smolin 1990 Nucl. Phys. B 331 80 1044493 1990NuPhB.331...80R 10.1016/0550-3213(90)90019-A Rovelli, C., Smolin, L.: Nucl. Phys. B 331, 80 (1990) 11. A. Corichi K. Krasnov 1998 Mod. Phys. Lett. A 13 1339 1635881 1998MPLA...13.1339C 10.1142/S0217732398001406 hep-th/9703177 Corichi, A., Krasnov, K.: Mod. Phys. Lett. A 13, 1339 (1998). hep-th/9703177 12. A. Ashtekar J. Lewandowski D. Marolf J. Mour ao T. Thiemann 1995 J. Math. Phys. 36 11 6456 1355916 1995JMP....36.6456A 0856.58006 10.1063/1.531252 gr-qc/9504018 Ashtekar, A., Lewandowski, J., Marolf, D., Mour ao, J., Thiemann, T.: J. Math. Phys. 36(11), 6456 (1995). gr-qc/9504018 13. A. Ashtekar J. Lewandowski 1995 J. Math. Phys. 36 5 2170 1329251 1995JMP....36.2170A 0844.58009 10.1063/1.531037 Ashtekar, A., Lewandowski, J.: J. 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Thiemann 2006 Class Quantum Grav. 23 1289 2205485 2006CQGra..23.1289B 1089.83013 10.1088/0264-9381/23/4/014 gr-qc/0405060 Brunnemann, J., Thiemann, T.: Class Quantum Grav. 23, 1289 (2006). gr-qc/0405060 20. J.. Brunnemann D. Rideout 2008 Class. Quant. Grav. 25 065001 2398702 2008CQGra..25f5001B 10.1088/0264-9381/25/6/065001 arXiv:0706.0469 Brunnemann, J.., Rideout, D.: Class. Quant. Grav. 25, 065001 (2008). arXiv:0706.0469 21. J. Brunnemann D. Rideout 2008 Class. Quant. Grav. 25 065002 2398703 2008CQGra..25f5002B 10.1088/0264-9381/25/6/065002 arXiv:0706.0382 Brunnemann, J., Rideout, D.: Class. Quant. Grav. 25, 065002 (2008). arXiv:0706.0382 22. M. Bojowald 2008 Living Rev. Relativity 11 4 2008LRR....11....4B 10.12942/lrr-2008-4 gr-qc/0601085, http://www.livingreviews.org/lrr-2008-4 Bojowald, M.: Living Rev. Relativity 11, 4 (2008). gr-qc/0601085 23. M. Bojowald 2000 Class. Quantum Grav. 17 1489 1752649 2000CQGra..17.1489B 0969.83035 10.1088/0264-9381/17/6/312 gr-qc/9910103 Bojowald, M.: Class. Quantum Grav. 17, 1489 (2000). gr-qc/9910103 24. M. Bojowald 2002 Class. Quantum Grav. 19 2717 1908125 2002CQGra..19.2717B 1008.83037 10.1088/0264-9381/19/10/313 gr-qc/0202077 Bojowald, M.: Class. Quantum Grav. 19, 2717 (2002). gr-qc/0202077 25. C. Fewster H. Sahlmann 2008 Class Quantum Grav 25 225015 2453388 2008CQGra..25v5015F 10.1088/0264-9381/25/22/225015 arXiv:0804.2541 Fewster, C., Sahlmann, H.: Class Quantum Grav 25, 225015 (2008). arXiv:0804.2541 26. J.M. Velhinho 2007 Class. Quantum Grav. 24 3745 2339420 2007CQGra..24.3745V 1129.83324 10.1088/0264-9381/24/14/013 arXiv:0704.2397. Velhinho, J.M.: Class. Quantum Grav. 24, 3745 (2007). arXiv:0704.2397. 27. T Thiemann 1998 Class Quantum Grav 15 839 1620209 1998CQGra..15..839T 0956.83013 10.1088/0264-9381/15/4/011 gr-qc/9606089 Thiemann, T.: Class Quantum Grav 15, 839 (1998). gr-qc/9606089 28. T. Thiemann 1998 Class. Quantum Grav. 15 1281 1623075 1998CQGra..15.1281T 0945.83016 10.1088/0264-9381/15/5/012 gr-qc/9705019 Thiemann, T.: Class. Quantum Grav. 15, 1281 (1998). gr-qc/9705019 29. M. Bojowald 2001 Phys. Rev. D 64 084018 1858727 2001PhRvD..64h4018B 10.1103/PhysRevD.64.084018 gr-qc/0105067 Bojowald, M.: Phys. Rev. D 64, 084018 (2001). gr-qc/0105067 30. J. Brunnemann T. Thiemann 2006 Class. Quantum Grav. 23 1395 2204689 2006CQGra..23.1395B 1097.83013 10.1088/0264-9381/23/5/001 gr-qc/0505032 Brunnemann, J., Thiemann, T.: Class. Quantum Grav. 23, 1395 (2006). gr-qc/0505032 31. M. Bojowald 2006 Class. Quantum Grav. 23 987 2202940 2006CQGra..23..987B 1087.83027 10.1088/0264-9381/23/3/023 gr-qc/0508118 Bojowald, M.: Class. Quantum Grav. 23, 987 (2006). gr-qc/0508118 32. J. Brunnemann T. Thiemann 2006 Class. Quantum Grav. 23 1429 2204690 2006CQGra..23.1429B 1089.83014 10.1088/0264-9381/23/5/002 gr-qc/0505033 Brunnemann, J., Thiemann, T.: Class. Quantum Grav. 23, 1429 (2006). gr-qc/0505033 1. W. Unruh 1997 Time, Gravity, and Quantum Mechanics Cambridge University Press Cambridge 23 94 Unruh, W.: Time, Gravity, and Quantum Mechanics pp. 23-94. Cambridge University Press, Cambridge (1997) 2. N. Weiss 1985 Phys Rev D 32 3228 815079 1985PhRvD..32.3228W 10.1103/PhysRevD.32.3228 Weiss, N.: Phys. Rev. D 32, 3228 (1985) 3. Jacobson, T.: (2000). hep-th/0001085 4. M. Bojowald P. Singh A. Skirzewski 2004 Phys. Rev. D 70 124022 2124706 2004PhRvD..70l4022B 10.1103/PhysRevD.70.124022 gr-qc/0408094 Bojowald, M., Singh, P., Skirzewski, A.: Phys. Rev. D 70, 124022 (2004). gr-qc/0408094 5. C. Rovelli L. Smolin 1994 Phys. Rev. Lett. 72 446 1256916 1994PhRvL..72..446R 0973.83523 10.1103/PhysRevLett.72.446 gr-qc/9308002 Rovelli, C., Smolin, L.: Phys. Rev. Lett. 72, 446 (1994). gr-qc/9308002 6. K. Giesel T. Thiemann 2007 Class Quantum Grav. 24 2465 2319427 2007CQGra..24.2465G 1117.83045 10.1088/0264-9381/24/10/003 gr-qc/0607099 Giesel, K., Thiemann, T.: Class Quantum Grav. 24, 2465 (2007). gr-qc/0607099 7. T. Thiemann 1998 Class Quantum Grav. 15 839 1620209 1998CQGra..15..839T 0956.83013 10.1088/0264-9381/15/4/011 gr-qc/9606089 Thiemann, T.: Class Quantum Grav. 15, 839 (1998). gr-qc/9606089 8. T. Thiemann 1998 Class Quantum Grav. 15 1281 1623075 1998CQGra..15.1281T 0945.83016 10.1088/0264-9381/15/5/012 gr-qc/9705019 Thiemann, T.: Class Quantum Grav. 15, 1281 (1998). gr-qc/9705019 9. T. Thiemann 1998 Class Quantum Grav. 15 875 1620213 1998CQGra..15..875T 10.1088/0264-9381/15/4/012 gr-qc/9606090 Thiemann, T.: Class Quantum Grav. 15, 875 (1998). gr-qc/9606090 10. T. Thiemann 1996 Phys. Lett. B 380 257 1398388 1996PhLB..380..257T 0945.83013 10.1016/0370-2693(96)00532-1 gr-qc/9606088 Thiemann, T.: Phys. Lett. B 380, 257 (1996). gr-qc/9606088 11. J. Lewandowski D. Marolf 1998 Int. J. Mod. Phys. D 7 299 1635756 1998IJMPD...7..299L 0936.83022 10.1142/S0218271898000231 gr-qc/9710016 Lewandowski, J., Marolf, D.: Int. J Mod. Phys. D 7, 299 (1998). gr-qc/9710016 12. R. Gambini J. Lewandowski D. Marolf J. Pullin 1998 Int. J Mod. Phys. D 7 97 1625059 1998IJMPD...7...97G 0936.83021 10.1142/S0218271898000103 gr-qc/9710018 Gambini, R., Lewandowski, J., Marolf, D., Pullin, J.: Int. J Mod. Phys. D 7, 97 (1998).gr-qc/9710018 13. A. Ashtekar J. Lewandowski H. Sahlmann 2003 Class Quantum Grav. 20 L11 1955775 2003CQGra..20L..11A 1025.83501 10.1088/0264-9381/20/1/103 gr-qc/0211012 Ashtekar, A., Lewandowski, J., Sahlmann, H.: Class Quantum Grav. 20, L11 (2003). gr-qc/0211012 14. H. Sahlmann T. Thiemann 2006 Class Quantum Grav. 23 867 2202936 2006CQGra..23..867S 1098.83014 10.1088/0264-9381/23/3/019 gr-qc/0207030 Sahlmann, H., Thiemann, T.: Class Quantum Grav. 23, 867 (2006). gr-qc/0207030 15. M. Bojowald 2009 -
Simulation of Anisotropic Rock Damage for Geologic Fracturing
NASA Astrophysics Data System (ADS)
Busetti, S.; Xu, H.; Arson, C. F.
2014-12-01
A continuum damage model for differential stress-induced anisotropic crack formation and stiffness degradation is used to study geologic fracturing in rocks. The finite element-based model solves for deformation in the quasi-linear elastic domain and determines the six component damage tensor at each deformation increment. The model permits an isotropic or anisotropic intact or pre-damaged reference state, and the elasticity tensor evolves depending on the stress path. The damage variable, similar to Oda's fabric tensor, grows when the surface energy dissipated by three-dimensional opened cracks exceeds a threshold defined at the appropriate scale of the representative elementary volume (REV). At the laboratory or wellbore scale (<1m) brittle continuum damage reflects microcracking, grain boundary separation, grain crushing, or fine delamination, such as in shale. At outcrop (1m-100m), seismic (10m-1000m), and tectonic (>1000m) scales the damaged REV reflects early natural fracturing (background or tectonic fracturing) or shear strain localization (fault process zone, fault-tip damage, etc.). The numerical model was recently benchmarked against triaxial stress-strain data from laboratory rock mechanics tests. However, the utility of the model to predict geologic fabric such as natural fracturing in hydrocarbon reservoirs was not fully explored. To test the ability of the model to predict geological fracturing, finite element simulations (Abaqus) of common geologic scenarios with known fracture patterns (borehole pressurization, folding, faulting) are simulated and the modeled damage tensor is compared against physical fracture observations. Simulated damage anisotropy is similar to that derived using fractured rock-mass upscaling techniques for pre-determined fracture patterns. This suggests that if model parameters are constrained with local data (e.g., lab, wellbore, or reservoir domain), forward modeling could be used to predict mechanical fabric at the relevant REV scale. This reference fabric also can be used as the starting material property to pre-condition subsequent deformation or fluid flow. Continuing efforts are to expand the present damage model to couple damage evolution with plasticity and with permeability for more geologically realistic simulation.
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Legal Requirements. Planning for Lutheran Elementary Schools. E06.
ERIC Educational Resources Information Center
Lutheran Church, Missouri Synod, St. Louis, MO.
Part of a 13-volume series designed to help Lutheran communities assess the feasibility of starting a Lutheran elementary school and to assist ongoing schools in current operation, this volume focuses on legal requirements affecting Lutheran schools. The first part deals with Lutheran schools under law and begins by touching on parental rights and…
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Song, Yue; Shen, Keng; He, Chun-Xia
2007-09-01
To construct recombinant adenoviral vector expressing autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter amplified by two-step transcription amplification (hTERTp-TSTA), and investigate its antitumor effect in ovarian cancer in vitro and in vivo. Recombinant adenoviruses expressing autocatalytic caspase-3 (rev-caspase-3) driven by hTERTp-TSTA were prepared, which were named as AdHTVP2G5-rev-casp3. AdHT-rev-casp3, Ad-rev-casp3 and AdHTVP2G5-EGEP, which express rev-caspase-3 driven by hTERTp, cytomegalovirus promoter (CMVp) and enhanced green fluorescent protein (EGFP), respectively, were used as controls. Western blot, cell counting kit (CCK-8), flow cytometry (FCM) and TdT-mediated dUTP-biotin nick end labeling (TUNEL) were used to detect the expression of p17, active subunit of caspase-3, and p85, and to measure cell survival rates, apoptotic rates and cell cycle distribution in ovarian cell line AO and normal human umbilical vein endothelial cell line HUVEC, following treatments of AdHTVP2G5-rev-casp3. subcutaneous tumor models and abdominally spread tumor models of human ovarian carcinoma using AO cells in BALB/c nude mice were established. Following treatments of AdHTVP2G5-rev-casp3, western blot was used to detect the expression of active caspase-3 in abdominally spread tumors and liver tissues, respectively, and the mouse survival rates and the volume of tumor nodules were measured, and the serum level of alanine transaminase (ALT) and aspartate transaminase (AST) were analyzed to monitor liver damages and HE staining was used to detect the histopathological changes of various organs. The levels of p17 expression in AdHTVP2G5-rev-casp3-treated AO cells were significantly higher than that in Ad-rev-casp3 or AdHT-rev-casp3 treated AO cells, while no expression was observed in AdHTVP2G5-rev-casp3-treated HUVEC. There was strong cell killing of AdHTVP2G5-rev-casp3 of hTERT positive AO cells, but not of the hTERT-negative HUVEC cells. Cell survival rate and apoptotic rate of AO cells treated with AdHTVP2G5-rev-casp3 were 17.8% and 40.2%, respectively, significantly different from that treated with AdHT-rev-casp3 (75.2% and 16.1%) at the multiplicity of infection (MOI) of 70 (P < 0.01). There was no significant difference in HUVEC cell survival rate and apoptotic rate between AdHTVP2G5-rev-casp3 treatment (97.7% and 2.1%, respectively) and AdHT-rev-casp3 treatment (98.5% and 1.7%, respectively) at the same MOI (P > 0.05). Significant expressions of active caspase-3 were shown in AdHTVP2G5-rev-casp3-treated tumors, whereas no expression was shown in liver. In contrast, both tumors and liver tissues showed active caspase-3 expression following treatments of Ad-rev-casp3. AdHTVP2G5-rev-casp3 and Ad-rev-casp3 prolonged mouse survival [mean survival time of (259 +/- 14) d and (213 +/- 16) d], when compared with treatment with AdHT-rev-casp3 [(177 +/- 12) d] and AdHTVP2G5-EGFP [(109 +/- 7) d; P < 0.01]. The mean volume of AdHTVP2G5-rev-casp3-treated tumor was 406 mm(3), significantly less than those of AdHT-rev-casp3 treatment (990 mm(3)), Ad-rev-casp3 treatment (645 mm(3)) and AdHTVP2G5-EGFP treatment (1728 mm(3); P < 0.01). The serum ALT and AST levels were not significantly elevated in AdHTVP2G5-rev-casp3-treated mice, whereas significantly elevated in Ad-rev-casp3-treated mice. No obvious lesions were found in any organ in AdHTVP2G5-rev-casp-treated group. Recombinant adenovirus AdHTVP2G5-rev-casp3 expressing rev-caspase-3 driven by hTERTp-TSTA can result in marked cell apoptosis with significant tumor targeting, suppressing tumor growth and prolonging the mouse survival, meanwhile, it can prevent against the liver toxicity induced by rev-caspase-3.
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NASA Astrophysics Data System (ADS)
Blum, Thomas; Christ, Norman; Hayakawa, Masashi; Izubuchi, Taku; Jin, Luchang; Jung, Chulwoo; Lehner, Christoph
2017-08-01
In our previous work, Blum et al. [Phys. Rev. Lett. 118, 022005 (2017), 10.1103/PhysRevLett.118.022005], the connected and leading disconnected hadronic light-by-light contributions to the muon anomalous magnetic moment (g -2 ) have been computed using lattice QCD ensembles corresponding to physical pion mass generated by the RBC/UKQCD Collaboration. However, the calculation is expected to suffer from a significant finite-volume error that scales like 1 /L2 where L is the spatial size of the lattice. In this paper, we demonstrate that this problem is cured by treating the muon and photons in infinite-volume, continuum QED, resulting in a weighting function that is precomputed and saved with affordable cost and sufficient accuracy. We present numerical results for the case when the quark loop is replaced by a muon loop, finding the expected exponential approach to the infinite volume limit and consistency with the known analytic result. We have implemented an improved weighting function which reduces both discretization and finite-volume effects arising from the hadronic part of the amplitude.
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ERIC Educational Resources Information Center
Croddy, Marshall; Degelman, Charles; Doggett, Keri; Hayes, Bill
This is volume one of a two-volume civics curriculum on law and effective citizenship for upper-elementary students. The lessons, set in American historical eras, engage students in cooperative-learning activities, role plays, simulations, readers theater, stories, and guided discussions, which introduce and reinforce law-related and civic…
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ERIC Educational Resources Information Center
Kaye, Elizabeth A., Ed.; Makos, Jeffrey J., Ed.
2010-01-01
This annual volume offers the most complete and current listings of the requirements for certification of a wide range of educational professionals at the elementary and secondary levels. "Requirements for Certification" is a valuable resource, making much-needed knowledge available in one straightforward volume. Appended are: (1) How to…
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ERIC Educational Resources Information Center
Kaye, Elizabeth A., Ed.
2011-01-01
This annual volume offers the most complete and current listings of the requirements for certification of a wide range of educational professionals at the elementary and secondary levels. "Requirements for Certification" is a valuable resource, making much-needed knowledge available in one straightforward volume. [For "Requirements…
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ERIC Educational Resources Information Center
Kaye, Elizabeth A., Ed.
2012-01-01
This annual volume offers the most complete and current listings of the requirements for certification of a wide range of educational professionals at the elementary and secondary levels. "Requirements for Certification" is a valuable resource, making much-needed knowledge available in one straightforward volume. [For "Requirements for…
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NASA Astrophysics Data System (ADS)
Heath, J. E.; Dewers, T. A.; Yoon, H.; Mozley, P.
2016-12-01
Heterogeneity from the nanometer to core and larger length scales is a major challenge to understanding coupled processes in shale. To develop methods to address this challenge, we present application of high throughput multi-beam scanning electron microscopy (mSEM) and nano-to-micro-scale mechanics to the Mancos Shale. We use a 61-beam mSEM to collect 6 nm resolution SEM images at the scale of several square millimeters. These images are analyzed for pore size and shape characteristics including spatial correlation and structure. Nano-indentation, micropillar compression, and axisymmetric testing at multiple length scales allows for examining the influence of sampling size on mechanical response. The combined data set is used to: investigate representative elementary volumes (and areas for the 2D images) for the Mancos Shale; determine if scale separation occurs; and determine if transport and mechanical properties at a given length scale can be statistically defined. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.
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ERIC Educational Resources Information Center
Wisconsin Univ., Madison.
This document is the second volume of the feasibility study report for the Wisconsin Elementary Teacher Education Project. It provides in part 1 data on program, planning and budgeting, including cost figures for preparing students in the present and new programs, marginal expenses, and costs for implementing the program on other campuses. Part 2…
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Cooperation in Japan. Grades Kindergarten-Third. Elementary Literature Series, Part 1.
ERIC Educational Resources Information Center
Mukai, Gary
The Stanford Program on International and Cross-Cultural Education (SPICE) represents a long-term effort by Stanford University to improve international and cross-cultural education in elementary and secondary schools. This volume of the elementary literature series focuses on the primary grades; utilizes primary source literature from Japan;…
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Elementary Science Supplement to the Syllabus. Level I (Ages 4 through 7).
ERIC Educational Resources Information Center
New York State Education Dept., Albany.
Developed to complement existing elementary science programs, the materials in this first volume of New York's Elementary Science Supplement to the Syllabus emphasize a direct experience, hands-on approach for children of ages 4 through 7. Major sections include: (1) guidelines for program activities (explaining the organizational format of the…
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Structure and Form. Elementary Science Activity Series, Volume 2.
ERIC Educational Resources Information Center
Blackwell, Frank F.
This book is number 2 of a series of elementary science books that presents a wealth of ideas for science activities for the elementary school teacher. Each activity includes a standard set of information designed to help teachers determine the activity's appropriateness for their students, plan its implementation, and help children focus on a…
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Single Crystal High Frequency Cavity-based EPR Spectroscopy of Single Molecule Magnets
2003-01-01
Rev. Lett. 76, 3830 (1996); L. Thomas, F. Lionti, R. Ballou, D. Gatteschi , R. Sessoli, B. Barbara, Nature (London) 383, 145 (1996). [2] G. Christou, D... Gatteschi , D.N. Hendrickson, and R. Sessoli, MRS Bulletin, Volume 25, No. 11, 66 (2000). [3] E. M. Chudnovsky, J. Tejada, Macroscopic Quantum...Rev. Sci. Instrum. 71, 186 (2000). [11] A. A. Mukhin V. D. Travkin, A. K. Zvezdin, S. P. Lebedev, A. Caneschi and D. Gatteschi , Europhys. Lett., 44
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Physical meaning of two-particle HBT measurements in case of correlated emission
NASA Astrophysics Data System (ADS)
Bialas, A.; Zalewski, K.
2004-07-01
It is shown that, in the presence of correlations in particle emission, the measured HBT radii are related to the correlation range rather than to the size of the interaction volume. Only in the case of weak correlations the standard interpretation may be applicable. The earlier discussion [Phys. Rev. Lett. 68 (1992) 1109; Phys. Rev. C 49 (1994) 2722] of the short-range correlations in configuration space is generalized to include also the correlations of particle momenta.
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Macroscopic Quantum Coherence and Computing
2005-02-08
G . Meyer, Phys. Rev. B, Vol. 59, No. 17 (1999). [4] V . K. Kornev, I. I. Soloviev, N. V . Klenov, N. F. Pedersen, I. V . Borisenko, P. B. Mozhaev and G ...Koval, and A. V . Ustinov, Nature 425, 155 (2003). [3] N. Gronbech-Jensen, Phys. Rev. B 45, 7315 (1992). [4] N. Gronbech-Jensen, M. G . Castellano, F...Makhlin, G . Schon, A. Shnirman, Reviews of modern physics, Volume 73, No. 2 (2001). [3] E. lI"ichev, V . Zakosarenko, R. P. J. Ijsselstejn, H. E. Hoenig, H
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Pinning mode of integer quantum Hall Wigner crystal of skyrmions
NASA Astrophysics Data System (ADS)
Zhu, Han; Sambandamurthy, G.; Chen, Y. P.; Jiang, P.-H.; Engel, L. W.; Tsui, D. C.; Pfeiffer, L. N.; West, K. W.
2009-03-01
Just away from integer Landau level (LL) filling factors ν, the dilute quasi-particles/holes at the partially filled LL form an integer-quantum-Hall Wigner crystal, which exhibits microwave pinning mode resonances [1]. Due to electron-electron interaction, it was predicted that the elementary excitation around ν= 1 is not a single spin flip, but a larger-scale spin texture, known as a skyrmion [2]. We have compared the pinning mode resonances [1] of integer quantum Hall Wigner crystals formed in the partly filled LL just away from ν= 1 and ν= 2, in the presence of an in-plane magnetic field. As an in-plane field is applied, the peak frequencies of the resonances near ν= 1 increase, while the peak frequencies below ν= 2 show neligible dependence on in-plane field. We interpret this observation as due to a skyrmion crystal phase around ν= 1 and a single-hole Wigner crystal phase below ν= 2. The in-plane field increases the Zeeman gap and causes shrinking of the skyrmion size toward single spin flips. [1] Yong P. Chen et al., Phys. Rev. Lett. 91, 016801 (2003). [2] S. L. Sondhi et al., Phys. Rev. B 47, 16 419 (1993); L. Brey et al., Phys. Rev. Lett. 75, 2562 (1995).
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Rotation of a Single Acetylene Molecule on Cu(001) by Tunneling Electrons in STM
NASA Astrophysics Data System (ADS)
Shchadilova, Yulia E.; Tikhodeev, Sergei G.; Paulsson, Magnus; Ueba, Hiromu
2013-11-01
We study the elementary processes behind one of the pioneering works on scanning tunneling microscope controlled reactions of single molecules [Stipe et al., Phys. Rev. Lett. 81, 1263 (1998)]. Using the Keldysh-Green function approach for the vibrational generation rate in combination with density functional theory calculations to obtain realistic parameters we reproduce the experimental rotation rate of an acetylene molecule on a Cu(100) surface as a function of bias voltage and tunneling current. This combined approach allows us to identify the reaction coordinate mode of the acetylene rotation and its anharmonic coupling with the C-H stretch mode. We show that three different elementary processes, the excitation of C-H stretch, the overtone ladder climbing of the hindered rotational mode, and the combination band excitation together explain the rotation of the acetylene molecule on Cu(100).
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NASA Astrophysics Data System (ADS)
Milani, G.; Bertolesi, E.
2017-07-01
A simple quasi analytical holonomic homogenization approach for the non-linear analysis of masonry walls in-plane loaded is presented. The elementary cell (REV) is discretized with 24 triangular elastic constant stress elements (bricks) and non-linear interfaces (mortar). A holonomic behavior with softening is assumed for mortar. It is shown how the mechanical problem in the unit cell is characterized by very few displacement variables and how homogenized stress-strain behavior can be evaluated semi-analytically.
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Funding Lutheran Elementary Schools. Planning for Lutheran Elementary Schools. E09.
ERIC Educational Resources Information Center
Lutheran Church, Missouri Synod, St. Louis, MO.
Part of a 13-volume series designed to help Lutheran communities assess the feasibility of starting a Lutheran elementary school and to assist ongoing schools in current operation, this handbook focuses on financial support for Lutheran schools. It attempts to present a comprehensive description of factors to be considered in funding a Lutheran…
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Damping of quasiparticles in a Bose-Einstein condensate coupled to an optical cavity
NASA Astrophysics Data System (ADS)
Kónya, G.; Szirmai, G.; Domokos, P.
2014-07-01
We present a general theory for calculating the damping rate of elementary density-wave excitations in a Bose-Einstein condensate strongly coupled to a single radiation field mode of an optical cavity. Thereby we give a detailed derivation of the huge resonant enhancement in the Beliaev damping of a density-wave mode, predicted recently by Kónya et al. [Phys. Rev. A 89, 051601(R) (2014), 10.1103/PhysRevA.89.051601]. The given density-wave mode constitutes the polaritonlike soft mode of the self-organization phase transition. The resonant enhancement takes place, in both the normal and the ordered phases, outside the critical region. We show that the large damping rate is accompanied by a significant frequency shift of this polariton mode. Going beyond the Born-Markov approximation and determining the poles of the retarded Green's function of the polariton, we reveal a strong coupling between the polariton and a collective mode in the phonon bath formed by the other density-wave modes.
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NASA Astrophysics Data System (ADS)
Qin, C.; Hassanizadeh, S.
2013-12-01
Multiphase flow and species transport though thin porous layers are encountered in a number of industrial applications, such as fuel cells, filters, and hygiene products. Based on some macroscale models like the Darcy's law, to date, the modeling of flow and transport through such thin layers has been mostly performed in 3D discretized domains with many computational cells. But, there are a number of problems with this approach. First, a proper representative elementary volume (REV) is not defined. Second, one needs to discretize a thin porous medium into computational cells whose size may be comparable to the pore sizes. This suggests that the traditional models are not applicable to such thin domains. Third, the interfacial conditions between neighboring layers are usually not well defined. Last, 3D modeling of a number of interacting thin porous layers often requires heavy computational efforts. So, to eliminate the drawbacks mentioned above, we propose a new approach to modeling multilayers of thin porous media as 2D interacting continua (see Fig. 1). Macroscale 2D governing equations are formulated in terms of thickness-averaged material properties. Also, the exchange of thermodynamic properties between neighboring layers is described by thickness-averaged quantities. In Comparison to previous macroscale models, our model has the distinctive advantages of: (1) it is rigorous thermodynamics-based model; (2) it is formulated in terms of thickness-averaged material properties which are easily measureable; and (3) it reduces 3D modeling to 2D leading to a very significant reduction of computation efforts. As an application, we employ the new approach in the study of liquid water flooding in the cathode of a polymer electrolyte fuel cell (PEFC). To highlight the advantages of the present model, we compare the results of water distribution with those obtained from the traditional 3D Darcy-based modeling. Finally, it is worth noting that, for specific case studies, a number of material properties in the model need to be determined experimentally, such as mass and heat exchange coefficients between neighboring layers. Fig. 1: Schematic representation of three thin porous layers, which may exchange mass, momentum, and energy. Also, a typical averaging domain (REV) is shown. Note that the layer thickness and thus the REV height can be spatially variable. Also, in reality, the layers are tightly stacked and there is no gap between them.
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Calculus Students' Understanding of Volume
ERIC Educational Resources Information Center
Dorko, Allison; Speer, Natasha M.
2013-01-01
Researchers have documented difficulties that elementary school students have in understanding volume. Despite its importance in higher mathematics, we know little about college students' understanding of volume. This study investigated calculus students' understanding of volume. Clinical interview transcripts and written responses to volume…
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1993-12-14
requirements of band structure engineering and superlative crystal quality extend a considerable challenge to the materials scientist / crystal grower...to nearly the same temperature as the signal of the Si substrate, which indicates a comparable exciton binding energy. Even in high quality SiGe-MQWs...5621 (1986) 13. L. Colombo, R. Resta , and S. Baroni, Phys. Rev. B 44, 5572 (1991) 14. G. L. McVay and A. R. DuCharme, Phys. Rev. B 9, 627 (1974) 15. L.C
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Students' Reasoning about Invariance of Volume as a Quantity
ERIC Educational Resources Information Center
Kara, Melike
2013-01-01
The aims of this study were to investigate how upper-elementary-grade students compare the volume of rectangular prisms of equal volume (specifically, students' noticing and reasoning for invariance of volume and coordination of the three linear dimensions of rectangular prisms) and how students' levels of sophistication in volume measurement…
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1982-01-29
N - Nw .VA COMPUTER PROGRAM USER’S MANUAL FOR . 0FIREFINDER DIGITAL TOPOGRAPHIC DATA VERIFICATION LIBRARY DUBBING SYSTEM VOLUME II DUBBING 29 JANUARY...Digital Topographic Data Verification Library Dubbing System, Volume II, Dubbing 6. PERFORMING ORG. REPORT NUMER 7. AUTHOR(q) S. CONTRACT OR GRANT...Software Library FIREFINDER Dubbing 20. ABSTRACT (Continue an revWee *Ide II necessary end identify by leek mauber) PThis manual describes the computer
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NASA Astrophysics Data System (ADS)
Jougnot, D.; Guarracino, L.
2016-12-01
The self-potential (SP) method is considered by most researchers the only geophysical method that is directly sensitive to groundwater flow. One source of SP signals, the so-called streaming potential, results from the presence of an electrical double layer at the mineral-pore water interface. When water flows through the pore space, it gives rise to a streaming current and a resulting measurable electrical voltage. Different approaches have been proposed to predict streaming potentials in porous media. One approach is based on the excess charge which is effectively dragged in the medium by the water flow. Following a recent theoretical framework, we developed a physically-based analytical model to predict the effective excess charge in saturated porous media. In this study, the porous media is described by a bundle of capillary tubes with a fractal pore-size distribution. First, an analytical relationship is derived to determine the effective excess charge for a single capillary tube as a function of the pore water salinity. Then, this relationship is used to obtain both exact and approximated expressions for the effective excess charge at the Representative Elementary Volume (REV) scale. The resulting analytical relationship allows the determination of the effective excess charge as a function of pore water salinity, fractal dimension and hydraulic parameters like porosity and permeability, which are also obtained at the REV scale. This new model has been successfully tested against data from the literature of different sources. One of the main finding of this study is that it provides a mechanistic explanation to the empirical dependence between the effective excess charge and the permeability that has been found by various researchers. The proposed petrophysical relationship also contributes to understand the role of porosity and water salinity on effective excess charge and will help to push further the use of streaming potential to monitor groundwater flow.
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NASA Astrophysics Data System (ADS)
Noorian Bidgoli, Majid; Jing, Lanru
2015-05-01
The effect of groundwater on strength and deformation behavior of fractured crystalline rocks is one of the important issues for design, performance and safety assessments of surface and subsurface rock engineering problems. However, practical difficulties make the direct in situ and laboratory measurements of these properties of fractured rocks impossible at present, since effects of complex fracture system hidden inside the rock masses cannot be accurately estimated. Therefore, numerical modeling needs to be applied. The overall objective of this paper is to deepen our understanding on the validity of the effective stress concept, and to evaluate the effects of water pressure on strength and deformation parameters. The approach adopted uses discrete element methods to simulate the coupled stress-deformation-flow processes in a fractured rock mass with model dimensions at a representative elementary volume (REV) size and realistic representation of fracture system geometry. The obtained numerical results demonstrate that water pressure has significant influence on the strength, but with minor effects on elastic deformation parameters, compared with significant influence by the lateral confining pressure. Also, the classical effective stress concept to fractured rock can be quite different with that applied in soil mechanics. Therefore, one should be cautious when applying the classical effective stress concept to fractured rock media.
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Dynamics in dense hard-sphere colloidal suspensions
NASA Astrophysics Data System (ADS)
Orsi, Davide; Fluerasu, Andrei; Moussaïd, Abdellatif; Zontone, Federico; Cristofolini, Luigi; Madsen, Anders
2012-01-01
The dynamic behavior of a hard-sphere colloidal suspension was studied by x-ray photon correlation spectroscopy and small-angle x-ray scattering over a wide range of particle volume fractions. The short-time mobility of the particles was found to be smaller than that of free particles even at relatively low concentrations, showing the importance of indirect hydrodynamic interactions. Hydrodynamic functions were derived from the data, and for moderate particle volume fractions (Φ≤ 0.40) there is good agreement with earlier many-body theory calculations by Beenakker and Mazur [Physica A0378-437110.1016/0378-4371(84)90206-1 120, 349 (1984)]. Important discrepancies appear at higher concentrations, above Φ≈ 0.40, where the hydrodynamic effects are overestimated by the Beenakker-Mazur theory, but predicted accurately by an accelerated Stokesian dynamics algorithm developed by Banchio and Brady [J. Chem. Phys.0021-960610.1063/1.1571819 118, 10323 (2003)]. For the relaxation rates, good agreement was also found between the experimental data and a scaling form predicted by the mode coupling theory. In the high concentration range, with the fluid suspensions approaching the glass transition, the long-time diffusion coefficient was compared with the short-time collective diffusion coefficient to verify a scaling relation previously proposed by Segrè and Pusey [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.77.771 77, 771 (1996)]. We discuss our results in view of previous experimental attempts to validate this scaling law [L. Lurio , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.84.785 84, 785 (2000)].
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NASA Technical Reports Server (NTRS)
Koskela, P. E.
1973-01-01
This addendum to the Mariner Mars 1971 Television Picture Catalog, Volume 2 (for abstract, see N73-20850) contains data for the Mariner 9 TV pictures taken after Rev 262. Some of the data presented in Volume 2 is brought up to date. The new provisional mapping pole is discussed, and tables provide the latitude and longitude with respect to the new pole, prime meridian, and rotation rate for the centerpoints of all the Mariner 9 TV pictures.
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Nutritional Supplementation of Disadvantaged Elementary-School Children
ERIC Educational Resources Information Center
Paige, David M.; And Others
1976-01-01
Examined with 177 disadvantaged elementary school students (5-9 years old, 99 percent Blacks) were the effects of the provision of a nutritionally fortified low-lactose food supplement on hematocrit values (volume percentage of erythrocytes in whole blood), growth, absenteeism, and lunch consumption. (IM)
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The Condition of Education, 1990. Volume 2: Postsecondary Education.
ERIC Educational Resources Information Center
Alsalam, Nabeel, Ed.; Rogers, Gayle Thompson, Ed.
The National Center for Education Statistics' annual statistical report on the condition of education in the United States is presented in two volumes for 1990. This volume covers postsecondary education, while the first volume addresses elementary and secondary education. Condition of education indicators (CEIs)--key data that measure the health…
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NASA Astrophysics Data System (ADS)
Mathieu, Jean-Philippe; Inal, Karim; Berveiller, Sophie; Diard, Olivier
2010-11-01
Local approach to brittle fracture for low-alloyed steels is discussed in this paper. A bibliographical introduction intends to highlight general trends and consensual points of the topic and evokes debatable aspects. French RPV steel 16MND5 (equ. ASTM A508 Cl.3), is then used as a model material to study the influence of temperature on brittle fracture. A micromechanical modelling of brittle fracture at the elementary volume scale already used in previous work is then recalled. It involves a multiscale modelling of microstructural plasticity which has been tuned on experimental inter-phase and inter-granular stresses heterogeneities measurements. Fracture probability of the elementary volume can then be computed using a randomly attributed defect size distribution based on realistic carbides repartition. This defect distribution is then deterministically correlated to stress heterogeneities simulated within the microstructure using a weakest-link hypothesis on the elementary volume, which results in a deterministic stress to fracture. Repeating the process allows to compute Weibull parameters on the elementary volume. This tool is then used to investigate the physical mechanisms that could explain the already experimentally observed temperature dependence of Beremin's parameter for 16MND5 steel. It is showed that, assuming that the hypothesis made in this work about cleavage micro-mechanisms are correct, effective equivalent surface energy (i.e. surface energy plus plastically dissipated energy when blunting the crack tip) for propagating a crack has to be temperature dependent to explain Beremin's parameters temperature evolution.
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Finite-size scaling for discontinuous nonequilibrium phase transitions
NASA Astrophysics Data System (ADS)
de Oliveira, Marcelo M.; da Luz, M. G. E.; Fiore, Carlos E.
2018-06-01
A finite-size scaling theory, originally developed only for transitions to absorbing states [Phys. Rev. E 92, 062126 (2015), 10.1103/PhysRevE.92.062126], is extended to distinct sorts of discontinuous nonequilibrium phase transitions. Expressions for quantities such as response functions, reduced cumulants, and equal area probability distributions are derived from phenomenological arguments. Irrespective of system details, all these quantities scale with the volume, establishing the dependence on size. The approach generality is illustrated through the analysis of different models. The present results are a relevant step in trying to unify the scaling behavior description of nonequilibrium transition processes.
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Multi-scale dynamical behavior of spatially distributed systems: a deterministic point of view
NASA Astrophysics Data System (ADS)
Mangiarotti, S.; Le Jean, F.; Drapeau, L.; Huc, M.
2015-12-01
Physical and biophysical systems are spatially distributed systems. Their behavior can be observed or modelled spatially at various resolutions. In this work, a deterministic point of view is adopted to analyze multi-scale behavior taking a set of ordinary differential equation (ODE) as elementary part of the system.To perform analyses, scenes of study are thus generated based on ensembles of identical elementary ODE systems. Without any loss of generality, their dynamics is chosen chaotic in order to ensure sensitivity to initial conditions, that is, one fundamental property of atmosphere under instable conditions [1]. The Rössler system [2] is used for this purpose for both its topological and algebraic simplicity [3,4].Two cases are thus considered: the chaotic oscillators composing the scene of study are taken either independent, or in phase synchronization. Scale behaviors are analyzed considering the scene of study as aggregations (basically obtained by spatially averaging the signal) or as associations (obtained by concatenating the time series). The global modeling technique is used to perform the numerical analyses [5].One important result of this work is that, under phase synchronization, a scene of aggregated dynamics can be approximated by the elementary system composing the scene, but modifying its parameterization [6]. This is shown based on numerical analyses. It is then demonstrated analytically and generalized to a larger class of ODE systems. Preliminary applications to cereal crops observed from satellite are also presented.[1] Lorenz, Deterministic nonperiodic flow. J. Atmos. Sci., 20, 130-141 (1963).[2] Rössler, An equation for continuous chaos, Phys. Lett. A, 57, 397-398 (1976).[3] Gouesbet & Letellier, Global vector-field reconstruction by using a multivariate polynomial L2 approximation on nets, Phys. Rev. E 49, 4955-4972 (1994).[4] Letellier, Roulin & Rössler, Inequivalent topologies of chaos in simple equations, Chaos, Solitons & Fractals, 28, 337-360 (2006).[5] Mangiarotti, Coudret, Drapeau, & Jarlan, Polynomial search and global modeling, Phys. Rev. E 86(4), 046205 (2012).[6] Mangiarotti, Modélisation globale et Caractérisation Topologique de dynamiques environnementales. Habilitation à Diriger des Recherches, Univ. Toulouse 3 (2014).
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Health Education Teaching Ideas: Elementary. Volume II.
ERIC Educational Resources Information Center
Hakala, Jane, Ed.; Buckner, W. P., Jr., Ed.; King, Karen, Ed.
This guide contains innovative learning activities and teaching ideas to enhance classroom instruction. The 40 papers are divided into 12 areas: "Health Attitudes and Values" (e.g., understanding elementary students' perceptions of health through art, narrative and discussion); "Mental Health" (e.g., building community through…
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NASA Astrophysics Data System (ADS)
Nakahata, Masayuki
This document is part of Subvolume A `Theory and Experiments' of Volume 21 `Elementary Particles' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms'. It contains of the Chapter `11 Experimental Results on Neutrino Masses and Mixings' the Section `11.2 Solar Neutrinos' with the content:
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ERIC Educational Resources Information Center
Jonas, Sister Ruth
This experiment examines a new psychological approach to foreign language study at the elementary school level. A principal objective is to determine the nature and importance of second language learning motivation in monolingual societies devoid of the daily living example of the target language and culture. A five-year French language sequence,…
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ERIC Educational Resources Information Center
Jonas, Sister Ruth
This experiment examines a new psychological approach to foreign language study at the elementary school level. A principal objective is to determine the nature and importance of second language learning motivation in monolingual societies devoid of the daily living example of the target language and culture. A five-year French language sequence,…
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Low-lying Photoexcited States of a One-Dimensional Ionic Extended Hubbard Model
NASA Astrophysics Data System (ADS)
Yokoi, Kota; Maeshima, Nobuya; Hino, Ken-ichi
2017-10-01
We investigate the properties of low-lying photoexcited states of a one-dimensional (1D) ionic extended Hubbard model at half-filling. Numerical analysis by using the full and Lanczos diagonalization methods shows that, in the ionic phase, there exist low-lying photoexcited states below the charge transfer gap. As a result of comparison with numerical data for the 1D antiferromagnetic (AF) Heisenberg model, it was found that, for a small alternating potential Δ, these low-lying photoexcited states are spin excitations, which is consistent with a previous analytical study [Katsura et al.,
Phys. Rev. Lett. 103, 177402 (2009) ]. As Δ increases, the spectral intensity of the 1D ionic extended Hubbard model rapidly deviates from that of the 1D AF Heisenberg model and it is clarified that this deviation is due to the neutral-ionic domain wall, an elementary excitation near the neutral-ionic transition point. -
Hydrodynamic description of spin Calogero-Sutherland model
NASA Astrophysics Data System (ADS)
Abanov, Alexander; Kulkarni, Manas; Franchini, Fabio
2009-03-01
We study a non-linear collective field theory for an integrable spin-Calogero-Sutherland model. The hydrodynamic description of this SU(2) model in terms of charge density, charge velocity and spin currents is used to study non-perturbative solutions (solitons) and examine their correspondence with known quantum numbers of elementary excitations [1]. A conventional linear bosonization or harmonic approximation is not sufficient to describe, for example, the physics of spin-charge (non)separation. Therefore, we need this new collective bosonic field description that captures the effects of the band curvature. In the strong coupling limit [2] this model reduces to integrable SU(2) Haldane-Shastry model. We study a non-linear coupling of left and right spin currents which form a Kac-Moody algebra. Our quantum hydrodynamic description for the spin case is an extension for the one found in the spinless version in [3].[3pt] [1] Y. Kato,T. Yamamoto, and M. Arikawa, J. Phys. Soc. Jpn. 66, 1954-1961 (1997).[0pt] [2] A. Polychronakos, Phys Rev Lett. 70,2329-2331(1993).[0pt] [3] A.G.Abanov and P.B. Wiegmann, Phys Rev Lett 95, 076402(2005)
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Reach for Reference. Four Recent Reference Books
ERIC Educational Resources Information Center
Safford, Barbara Ripp
2004-01-01
This article provides descriptions of four new science and technology encyclopedias that are appropriate for inclusion in upper elementary and/or middle school reference collections. "The Macmillan Encyclopedia of Weather" (Stern, Macmillan Reference/Gale), a one-volume encyclopedia for upper elementary and middle level students, is a…
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Learn Japanese--Elementary School Text, Volume III.
ERIC Educational Resources Information Center
Sato, Yaeko; And Others
This volume is the teacher's text for the first semester program on level two (fourth grade). See AL 001 718 for Volume I and ED 019 666 for Volume II. Text materials for the second level continue to introduce new structures systematically, according to the pupils' interest, ability, and rate of learning. Dialogs for level two, Volumes III and IV,…
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Elementary Science Teacher Education: International Perspectives on Contemporary Issues and Practice
ERIC Educational Resources Information Center
Appleton, Ken, Ed.
2006-01-01
Reflecting recent policy and standards initiatives, emerging research agendas, and key innovations, this volume provides a contemporary overview of important developments and issues that have that have in recent years shaped elementary science education pre-service courses and professional development, and practices that are shaping future…
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TLC for Growing Minds. Microcomputer Projects. Elementary Intermediate Microcomputer Projects.
ERIC Educational Resources Information Center
Buxton, Marilyn
Designed to improve students' thinking, learning, and creative skills while they learn to program a microcomputer in BASIC programing language, this book for intermediate learners at the elementary school level provides a variety of microcomputer activities designed to extend the concepts learned in accompanying instructional manuals (Volumes 3…
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Methods and Resources for Elementary and Middle-School Social Studies.
ERIC Educational Resources Information Center
Stockard, James W., Jr.
Designed for preservice elementary and/or middle school teachers, this methods and resources volume compiles well-researched information on social studies education. It uses the standards recommended by the National Council for the Social Studies (NCSS) as a foundation, thoroughly discussing the core disciplines and thematic strands. The book…
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Energy Management System Successful in Indiana Elementary School.
ERIC Educational Resources Information Center
School Business Affairs, 1984
1984-01-01
The new Oregon-Davis Elementary School in rural Indiana embodies state-of-the-art energy management. Its environmental systems include thorough insulation, dual heating and cooling equipment for flexible loads, and decentralized computer controls. A heat recovery unit and variable-air-volume discharge ducts also contribute to conservation. (MCG)
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The Principal and Fiscal Management. Elementary Principal Series No. 6.
ERIC Educational Resources Information Center
Walters, James K.; Marconnit, George D.
The sixth of six volumes in the "Elementary Principal Series," this booklet is designed to help principals develop sound fiscal management strategies at the building level. The first section reviews Indiana statutory provisions for handling extracurricular and booster group funds. The second section presents guidelines for managing…
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The Mathematics Education of Elementary Teachers: Issues and Strategies for Content Courses
ERIC Educational Resources Information Center
Hart, Lynn C., Ed.; Oesterle, Susan, Ed.; Auslander, Susan Swars, Ed.; Kajander, Ann, Ed.
2016-01-01
This book is an edited volume addressing specific issues of significance for individuals involved with the undergraduate mathematics content preparation of prospective elementary teachers (PSTs). Teaching mathematics content courses to this group of students presents unique challenges. While some PSTs enter their teacher preparation with weak…
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The Principal and Supervision. Elementary Principal Series No. 4.
ERIC Educational Resources Information Center
Luehe, Bill
The fourth of six volumes in the "Elementary Principal Series," this booklet offers new principals a set of ideas, procedures, and examples associated with effective teacher supervision. The principal-teacher supervisory relationship has changed dramatically over recent years. The principal is no longer an inspector, but a colleague…
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ERIC Educational Resources Information Center
Johansen, Barry-Craig P.; And Others
Spanish translations of 19 of the Minneapolis (Minnesota) Public Schools' elementary school science units are presented. The materials were translated for use in a partial immersion program. Unit topics include, among others: magnets, organisms (grade 1), seeds and plants (grade 1), butterflies (grade 2), electricity (grade 3), the food chain…
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Entelek Programmed Instruction Guide. Volume l: Elementary/High School. 3rd Edition.
ERIC Educational Resources Information Center
Entelek, Inc., Newburyport, MA.
Individualized instruction has become an important objective in schools. This programmed instruction guide provides information about the ENTELEK system for elementary and high schools. The data bank covers a variety of subject areas and is catalogued according to the Dewey Decimal System: library; psychology; logic; political science; economics;…
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Observing and Producing Sounds, Elementary School Science, Level Four, Teaching Manual.
ERIC Educational Resources Information Center
Hale, Helen E.
This pilot teaching unit is one of a series developed for use in elementary school science programs. This unit is designed to help children discover specific concepts which relate to sound, such as volume, pitch, and echo. The student activities employ important scientific processes, such as observation, communication, inference, classification,…
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NASA Astrophysics Data System (ADS)
Corsini, Niccolò R. C.; Greco, Andrea; Hine, Nicholas D. M.; Molteni, Carla; Haynes, Peter D.
2013-08-01
We present an implementation in a linear-scaling density-functional theory code of an electronic enthalpy method, which has been found to be natural and efficient for the ab initio calculation of finite systems under hydrostatic pressure. Based on a definition of the system volume as that enclosed within an electronic density isosurface [M. Cococcioni, F. Mauri, G. Ceder, and N. Marzari, Phys. Rev. Lett. 94, 145501 (2005)], 10.1103/PhysRevLett.94.145501, it supports both geometry optimizations and molecular dynamics simulations. We introduce an approach for calibrating the parameters defining the volume in the context of geometry optimizations and discuss their significance. Results in good agreement with simulations using explicit solvents are obtained, validating our approach. Size-dependent pressure-induced structural transformations and variations in the energy gap of hydrogenated silicon nanocrystals are investigated, including one comparable in size to recent experiments. A detailed analysis of the polyamorphic transformations reveals three types of amorphous structures and their persistence on depressurization is assessed.
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Learn Japanese--Elementary School Text, Volume IV.
ERIC Educational Resources Information Center
Sato, Yaeko; And Others
Volume IV of this series is the second semester program for level two students. New materials are combined with some of the vocabulary and structural points introduced in the first three volumes to present a meaningful and interesting dialog for each lesson. (See ED 019 666, AL 001 718 and AL 001 743 for Volumes I, II, and III.) This text, a…
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Folksong in the Classroom. Volume II, Numbers 1-3, 1981-82.
ERIC Educational Resources Information Center
Scott, John A., Ed.; Seidman, Laurence I., Ed.
1982-01-01
The second volume of a newsletter for integrating folk music into elementary and secondary social studies, literature, and humanities courses, this publication contains three issues of the newsletter which together offer a compilation of folksongs from various historical periods and cultures. The first issue of this volume contains miscellaneous…
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1978-79 Michigan Social Studies Textbook Study, Volume II.
ERIC Educational Resources Information Center
Chapman, John M., Ed.
This document, Volume II of a two-volume report on the extent to which four elementary level social studies programs reflect the multi-racial, multi-cultural nature of American society, contains individual reports of each reviewer. Fifteen reviewers examined textbooks and accompanying instructional materials according to the degree to which they…
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1978-79 Michigan Social Studies Textbook Study, Volume I.
ERIC Educational Resources Information Center
Chapman, John, M., Ed.
This document represents Volume I of a two volume study to determine the extent to which four elementary level social studies programs reflect the multi-racial, multi-cultural nature of American society. The document is presented in three parts. Part I covers the Michigan Social Studies Textbook Act, an historical overview of previous Michigan…
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ERIC Educational Resources Information Center
Crosby, Glenn; And Others
A group of scientists and science educators of Washington State University has developed and pilot tested an integrated physical science program designed for preservice elementary school teachers. This document includes the syllabus and class materials for the Chemistry block of the physical science courses developed by the group. Included are…
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Machine Shop Suggested Job and Task Sheets. Part I. 25 Elementary Jobs.
ERIC Educational Resources Information Center
Texas A and M Univ., College Station. Vocational Instructional Services.
This volume consists of elementary job and task sheets adaptable for use in the regular vocational industrial education programs for the training of machinists and machine shop operators. Twenty-five simple machine shop job sheets are included. Some or all of this material is provided for each job sheet: an introductory sheet with aim, checking…
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ERIC Educational Resources Information Center
Webster, Gary
A group of scientists and science educators at Washington State University has developed and pilot tested an integrated physical science program designed for preservice elementary school teachers. This document includes the syllabus and class materials for the Geology block of the physical science courses developed by the group. Included are…
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ERIC Educational Resources Information Center
Lutz, Julie H.; Orlich, Donald C.
A group of scientists and science educators at Washington State University has developed and pilot tested an integrated physical science program designed for preservice elementary school teachers. This document includes the syllabus and class materials for the Astronomy block of the physical science courses developed by the group. Included are…
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Self-diffusion in compressively strained Ge
NASA Astrophysics Data System (ADS)
Kawamura, Yoko; Uematsu, Masashi; Hoshi, Yusuke; Sawano, Kentarou; Myronov, Maksym; Shiraki, Yasuhiro; Haller, Eugene E.; Itoh, Kohei M.
2011-08-01
Under a compressive biaxial strain of ˜ 0.71%, Ge self-diffusion has been measured using an isotopically controlled Ge single-crystal layer grown on a relaxed Si0.2Ge0.8 virtual substrate. The self-diffusivity is enhanced by the compressive strain and its behavior is fully consistent with a theoretical prediction of a generalized activation volume model of a simple vacancy mediated diffusion, reported by Aziz et al. [Phys. Rev. B 73, 054101 (2006)]. The activation volume of (-0.65±0.21) times the Ge atomic volume quantitatively describes the observed enhancement due to the compressive biaxial strain very well.
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Grain-scale modeling and splash parametrization for aeolian sand transport.
Lämmel, Marc; Dzikowski, Kamil; Kroy, Klaus; Oger, Luc; Valance, Alexandre
2017-02-01
The collision of a spherical grain with a granular bed is commonly parametrized by the splash function, which provides the velocity of the rebounding grain and the velocity distribution and number of ejected grains. Starting from elementary geometric considerations and physical principles, like momentum conservation and energy dissipation in inelastic pair collisions, we derive a rebound parametrization for the collision of a spherical grain with a granular bed. Combined with a recently proposed energy-splitting model [Ho et al., Phys. Rev. E 85, 052301 (2012)PLEEE81539-375510.1103/PhysRevE.85.052301] that predicts how the impact energy is distributed among the bed grains, this yields a coarse-grained but complete characterization of the splash as a function of the impact velocity and the impactor-bed grain-size ratio. The predicted mean values of the rebound angle, total and vertical restitution, ejection speed, and number of ejected grains are in excellent agreement with experimental literature data and with our own discrete-element computer simulations. We extract a set of analytical asymptotic relations for shallow impact geometries, which can readily be used in coarse-grained analytical modeling or computer simulations of geophysical particle-laden flows.
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Work distributions of one-dimensional fermions and bosons with dual contact interactions
NASA Astrophysics Data System (ADS)
Wang, Bin; Zhang, Jingning; Quan, H. T.
2018-05-01
We extend the well-known static duality [M. Girardeau, J. Math. Phys. 1, 516 (1960), 10.1063/1.1703687; T. Cheon and T. Shigehara, Phys. Rev. Lett. 82, 2536 (1999), 10.1103/PhysRevLett.82.2536] between one-dimensional (1D) bosons and 1D fermions to the dynamical version. By utilizing this dynamical duality, we find the duality of nonequilibrium work distributions between interacting 1D bosonic (Lieb-Liniger model) and 1D fermionic (Cheon-Shigehara model) systems with dual contact interactions. As a special case, the work distribution of the Tonks-Girardeau gas is identical to that of 1D noninteracting fermionic system even though their momentum distributions are significantly different. In the classical limit, the work distributions of Lieb-Liniger models (Cheon-Shigehara models) with arbitrary coupling strength converge to that of the 1D noninteracting distinguishable particles, although their elementary excitations (quasiparticles) obey different statistics, e.g., the Bose-Einstein, the Fermi-Dirac, and the fractional statistics. We also present numerical results of the work distributions of Lieb-Liniger model with various coupling strengths, which demonstrate the convergence of work distributions in the classical limit.
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Elementary test for nonclassicality based on measurements of position and momentum
NASA Astrophysics Data System (ADS)
Fresta, Luca; Borregaard, Johannes; Sørensen, Anders S.
2015-12-01
We generalize a nonclassicality test described by Kot et al. [Phys. Rev. Lett. 108, 233601 (2012), 10.1103/PhysRevLett.108.233601], which can be used to rule out any classical description of a physical system. The test is based on measurements of quadrature operators and works by proving a contradiction with the classical description in terms of a probability distribution in phase space. As opposed to the previous work, we generalize the test to include states without rotational symmetry in phase space. Furthermore, we compare the performance of the nonclassicality test with classical tomography methods based on the inverse Radon transform, which can also be used to establish the quantum nature of a physical system. In particular, we consider a nonclassicality test based on the so-called filtered back-projection formula. We show that the general nonclassicality test is conceptually simpler, requires less assumptions on the system, and is statistically more reliable than the tests based on the filtered back-projection formula. As a specific example, we derive the optimal test for quadrature squeezed single-photon states and show that the efficiency of the test does not change with the degree of squeezing.
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Song, Yue; Shen, Keng; Yu, Jing-rong
2007-11-06
To construct recombinant adenoviral vector expressing autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter (hTERTp), and investigate its antitumor effect on ovarian cancer in vitro and in vivo. Recombinant adenovirus expressing autocatalytic caspase-3 (rev-csapase-3) driven by hTERTp, AdHT-rev-casp3, was constructed. Ad-rev-casp3 expressing rev-caspase-3 driven by cytomegalovirus promoter (CMVp) was used as a positive control. hTERT positive human ovarian cancer cells of the line AO and hTERT-negative human umbilical venous endothelial cells (HUVECs) were cultured and transfected with AdHT-rev-casp3, Ad-rev-casp3, or Ad-EGFG expressing enhanced green fluorescent protein as control group. Western blotting, Cell Counting Kit (CCK-8), flow cytometry, and TUNEL were used to detect the expression of p17, active subunit of caspase-3, and p85, a poly ADP-ribose polymerase (PARP) cleavage fragment, and they were also used to measure the cell survival rate and apoptotic rate. Western blotting was used to detect the expression of active caspase-3 and its substrate PARP in the AO cells and HUVECs. Twenty nude BALB/c mice were inoculated subcutaneously with AO cells to establish subcutaneous tumor models, when the tumor grew to the volume of 150 mm3 the rats were divided into 4 equal groups to undergo intra-tumor injection of AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, and phosphate-buffered saline (PBS) respectively, the survival rate tumor inhibition rate was observed, 72 days later the mice were killed with their livers and tumors taken out, and Western blotting was used to detect the expression of active caspase-3. Another 40 mice underwent intraperitoneal injection of AO cells to establish intraperitoneal transplanted tumor models, 21 days later the rats were divided into 4 equal groups to be injected intraperitoneally with AdHT-rev-casp3, Ad-rev-casp3, Ad-EGFG, or PBS, the survival rate was observed, and the blood levels of alanine transaminase (ALT) and aspartate transaminase (AST) were detected. Following the administration of AdHT-rev-casp3, active caspase-3 protein was significantly expressed, and the levels of p17 and p85 expressions were significantly elevated in AO cells, while no expressions of p17 and p85 was observed in HUVEC. In contrast, both AO and HUVEC expressed high levels of p17 and p85 protein after administrations of Ad-rev-casp3. AdHT-rev-casp3 dose-dependently killed the hTERT positive AO cells, however, showed no killing effect on the hTERT-negative HUVEC cells; whereas Ad-rev-casp3 was cytotoxic independent of the hTERT status of the cells. The killing effect of Ad-rev-casp3 was stronger than that of AdHT-rev-casp3. Treated with AdHT-rev-cap3 the expression levels of the caspase-3 fragment p17 and PARP cleavage fragment p85 of the AO cells were significantly higher than those before the treatment, however, the expression levels of p17 and p85 were both weaker than those of the AO cells treated with Ad-rev-casp-3. Though treated with AdHT-rev-casp-3, there was still no remarkable expression of p17 and p85 in the HUVECs, however, rather high protein expression levels of p17 and p85 was shown. After treatment with AdHT-rev-casp3 remarkable expression of active caspase-3 was seen in the tumor collected from the mouse body, but not in the liver; however, high caspase-3 expression level was shown in both the liver and tumor after the treatment of Ad-rev-casp-3. 53 days after treatment the tumor suppression rate of the AdHT-rev-casp3 and ad-rev-casp-3 groups were 60% and 70% respectively, both significantly higher than that of the control group. The survival rates of the mice treated with AdHT-rev-casp3 and Ad-rev-casp-3 were both significantly longer than that of the PBS group; however the survival rate of the Ad-rev-casp-3 group was longer than that of the AdHT-rev-casp3 group. The serum ALT and AST levels were not significantly elevated in the AdHT-rev-casp3-treated mice, whereas 7-9-times that before treatment in the Ad-rev-casp3-treated mice. Recombinant adenovirus AdHT-rev-casp3 expressing rev-caspase-3 driven by hTERTp effectively causes cell apoptosis targeting tumor, significantly suppresses tumor growth and prolongs the mouse survival duration, with mild liver toxicity.
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Hargrave, Catriona; Deegan, Timothy; Bednarz, Tomasz; Poulsen, Michael; Harden, Fiona; Mengersen, Kerrie
2018-05-17
To describe a Bayesian network (BN) and complementary visualization tool that aim to support decision-making during online cone-beam computed tomography (CBCT)-based image-guided radiotherapy (IGRT) for prostate cancer patients. The BN was created to represent relationships between observed prostate, proximal seminal vesicle (PSV), bladder and rectum volume variations, an image feature alignment score (FAS TV _ OAR ), delivered dose, and treatment plan compliance (TPC). Variables influencing tumor volume (TV) targeting accuracy such as intrafraction motion, and contouring and couch shift errors were also represented. A score of overall TPC (FAS global ) and factors such as image quality were used to inform the BN output node providing advice about proceeding with treatment. The BN was quantified using conditional probabilities generated from published studies, FAS TV _ OAR /global modeling, and a survey of IGRT decision-making practices. A new IGRT visualization tool (IGRT REV ), in the form of Mollweide projection plots, was developed to provide a global summary of residual errors after online CBCT-planning CT registration. Sensitivity and scenario analyses were undertaken to evaluate the performance of the BN and the relative influence of the network variables on TPC and the decision to proceed with treatment. The IGRT REV plots were evaluated in conjunction with the BN scenario testing, using additional test data generated from retrospective CBCT-planning CT soft-tissue registrations for 13/36 patients whose data were used in the FAS TV _ OAR /global modeling. Modeling of the TV targeting errors resulted in a very low probability of corrected distances between the CBCT and planning CT prostate or PSV volumes being within their thresholds. Strength of influence evaluation with and without the BN TV targeting error nodes indicated that rectum- and bladder-related network variables had the highest relative importance. When the TV targeting error nodes were excluded from the BN, TPC was sensitive to observed PSV and rectum variations while the decision to treat was sensitive to observed prostate and PSV variations. When root nodes were set so the PSV and rectum variations exceeded thresholds, the probability of low TPC increased to 40%. Prostate and PSV variations exceeding thresholds increased the likelihood of repositioning or repeating patient preparation to 43%. Scenario testing using the test data from 13 patients, demonstrated two cases where the BN provided increased high TPC probabilities, despite some of the prostate and PSV volume variation metrics not being within tolerance. The IGRT REV tool was effective in highlighting and quantifying where TV and OAR variations occurred, supporting the BN recommendation to reposition the patient or repeat their bladder and bowel preparation. In another case, the IGRT REV tool was also effective in highlighting where PSV volume variation significantly exceeded tolerance when the BN had indicated to proceed with treatment. This study has demonstrated that both the BN and IGRT REV plots are effective tools for inclusion in a decision support system for online CBCT-based IGRT for prostate cancer patients. Alternate approaches to modeling TV targeting errors need to be explored as well as extension of the BN to support offline IGRT decisions related to adaptive radiotherapy. © 2018 American Association of Physicists in Medicine.
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2017-06-05
DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response...control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From - To) 4. TITLE AND...THIS PAGE 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 Cost & Performance Report June 2017
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ERIC Educational Resources Information Center
Guerrero, Frank; Abbott, Lori
This second volume of a four-volume evaluation of the 1988-89 New York City School Community Education Program (also known as the Umbrella Program) comprises reports evaluating nine innovative elementary school projects on social, ethnical, and environmental studies, four of which included staff development workshops. Evaluation sources included…
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ERIC Educational Resources Information Center
Marashi, Mehdi
This volume contains achievement tests designed for American students studying Persian at the elementary level. They are constructed on the basis of materials related to course syllabi. Preceding the tests, the sources of the test data are reviewed and the main ones are listed. The allocation of points in each section of the test syllabus is…
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ERIC Educational Resources Information Center
Community School District 18, Brooklyn, NY.
This is the second part of a two-part teacher's manual for an ISS-based elementary school course in the metric system. Behavioral objectives and student activities are included. Topics include: (1) capacity; (2) calculation of volume and surface area of cylinders and cones; (3) mass; (4) temperature; and (5) metric conversions. (BB)
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Instrumentation for Applied Physics and Industrial Applications
NASA Astrophysics Data System (ADS)
Hillemanns, H.; Le Goff, J.-M.
This document is part of Part 2 'Principles and Methods' of Subvolume B 'Detectors for Particles and Radiation' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the Section '7.3 Instrumentation for Applied Physics and Industrial Applications' of Chapter '7 Applications of Detectors in Technology; Medicine and Other Fields' with the content:
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ERIC Educational Resources Information Center
Vaidyanathan, A., Ed.; Nair, P. R. Gopinathan, Ed.
There are wide variations in educational attainment and literacy rates across the regions and social classes of India. A national project examined participation in and the quality of elementary education in nine states of India, focusing on rural areas and the situation of disadvantaged persons, especially girls and the scheduled castes and…
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NASA Astrophysics Data System (ADS)
Kohanoff, Jorge; Pinilla, Carlos; Youngs, Tristan G. A.; Artacho, Emilio; Soler, José M.
2011-10-01
The role of dispersion or van de Waals (VDW) interactions in imidazolium-based room-temperature ionic liquids is studied within the framework of density functional theory, using a recently developed non-empirical functional [M. Dion, H. Rydberg, E. Schröder, D. C. Langreth, and B. I. Lundqvist, Phys. Rev. Lett. 92, 246401 (2004), 10.1103/PhysRevLett.92.246401], as efficiently implemented in the SIESTA code [G. Román-Pérez and J. M. Soler, Phys. Rev. Lett. 103, 096102 (2009), 10.1103/PhysRevLett.103.096102]. We present results for the equilibrium structure and lattice parameters of several crystalline phases, finding a general improvement with respect to both the local density (LDA) and the generalized gradient approximations (GGA). Similar to other systems characterized by VDW bonding, such as rare gas and benzene dimers as well as solid argon, equilibrium distances and volumes are consistently overestimated by ≈7%, compared to -11% within LDA and 11% within GGA. The intramolecular geometries are retained, while the intermolecular distances and orientations are significantly improved relative to LDA and GGA. The quality is superior to that achieved with tailor-made empirical VDW corrections ad hoc [M. G. Del Pópolo, C. Pinilla, and P. Ballone, J. Chem. Phys. 126, 144705 (2007), 10.1063/1.2715571]. We also analyse the performance of an optimized version of this non-empirical functional, where the screening properties of the exchange have been tuned to reproduce high-level quantum chemical calculations [J. Klimes, D. Bowler, and A. Michaelides, J. Phys.: Condens. Matter 22, 074203 (2010), 10.1088/0953-8984/22/7/074203]. The results for solids are even better with volumes and geometries reproduced within 2% of experimental data. We provide some insight into the issue of polymorphism of [bmim][Cl] crystals, and we present results for the geometry and energetics of [bmim][Tf] and [mmim][Cl] neutral and charged clusters, which validate the use of empirical force fields.
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Equilibration and aging of dense soft-sphere glass-forming liquids
NASA Astrophysics Data System (ADS)
Sánchez-Díaz, Luis Enrique; Ramírez-González, Pedro; Medina-Noyola, Magdaleno
2013-05-01
The recently developed nonequilibrium extension of the self-consistent generalized Langevin equation theory of irreversible relaxation [Ramírez-González and Medina-Noyola, Phys. Rev. E10.1103/PhysRevE.82.061503 82, 061503 (2010); Ramírez-González and Medina-Noyola, Phys. Rev. E10.1103/PhysRevE.82.061504 82, 061504 (2010)] is applied to the description of the irreversible process of equilibration and aging of a glass-forming soft-sphere liquid that follows a sudden temperature quench, within the constraint that the local mean particle density remains uniform and constant. For these particular conditions, this theory describes the nonequilibrium evolution of the static structure factor S(k;t) and of the dynamic properties, such as the self-intermediate scattering function FS(k,τ;t), where τ is the correlation delay time and t is the evolution or waiting time after the quench. Specific predictions are presented for the deepest quench (to zero temperature). The predicted evolution of the α-relaxation time τα(t) as a function of t allows us to define the equilibration time teq(ϕ), as the time after which τα(t) has attained its equilibrium value ταeq(ϕ). It is predicted that both, teq(ϕ) and ταeq(ϕ), diverge as ϕ→ϕ(a), where ϕ(a) is the hard-sphere dynamic-arrest volume fraction ϕ(a)(≈0.582), thus suggesting that the measurement of equilibrium properties at and above ϕ(a) is experimentally impossible. The theory also predicts that for fixed finite waiting times t, the plot of τα(t;ϕ) as a function of ϕ exhibits two regimes, corresponding to samples that have fully equilibrated within this waiting time (ϕ≤ϕ(c)(t)), and to samples for which equilibration is not yet complete (ϕ≥ϕ(c)(t)). The crossover volume fraction ϕ(c)(t) increases with t but saturates to the value ϕ(a).
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Harvard Education Letter, 1999.
ERIC Educational Resources Information Center
Graves-Desai, Kelly, Ed.
1999-01-01
This document is comprised of the six issues in volume 15 of the Harvard Education Letter, a bimonthly newsletter addressing current issues in elementary and secondary education. Articles in this volume include the following: (1) January-February--"Retention vs. Social Promotion: Schools Search for Alternatives" (Kelly), and "School…
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The Harvard Education Letter, 1997.
ERIC Educational Resources Information Center
Graves-Desai, Kelly, Ed.; Maloney, Karen, Ed.
1997-01-01
This document is comprised of volume 13 of the Harvard Education Letter, published bimonthly and addressing current issues in elementary and secondary education. Articles in the six issues of this volume include: (1) January-February --"Making Detracking Work" (Lynn and Wheelock), "Developing a Culture of High Expectations for…
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Parents and Federal Education Programs. Volume 4: Title VII. The Study of Parental Involvement.
ERIC Educational Resources Information Center
Cadena-Munoz, Raquel; Keesling, J. Ward
This fourth volume in a seven-volume study is part of a larger study of parental involvement in four federal programs in selected school districts across the country. Presented here are results of an intensive examination of school district programs funded by Title VII of the Elementary and Secondary Education Act. Site studies of Title VII…
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ERIC Educational Resources Information Center
White, Sammis B.; Rue, Richard C.
An average of 33.5 percent of school district expenditures is spent on classroom teachers' compensation in Wisconsin elementary schools. The range varies from a low of 21.4 percent to a high of 45.9 percent. Financial data were analyzed from the survey responses of 110 of Wisconsin's 431 districts. The reasons for the average proportion spent on…
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ERIC Educational Resources Information Center
Department of Education, Washington, DC.
This volume discusses "Educational Excellence for All Children Act of 1999, the proposed reauthorization of the Elementary and Secondary Education Act (ESEA), which was established in 1965 as part of Lyndon Johnson's "War on Poverty" program. The proposed 1999 Act builds upon the 1994 reauthorization of ESEA titled "Improving…
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ERIC Educational Resources Information Center
Rockwood, Stacy F.
This paper outlines the procedures used at the University of Cincinnati for establishing a field based elementary teacher education program in the form of a field guide. The first step involves a meeting with university faculty to discuss the implications of such a program. Step two involves meeting with the elementary school principal and selling…
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The Effects of Using Space to Teach Standard Elementary School Curriculum
NASA Technical Reports Server (NTRS)
Ewell, Robert N.
1996-01-01
This brief report and recommendation for further research brings to a formal close this effort, the original purpose of which is described in detail in The effects of using space to teach standard elementary school curriculum, Volume 1, included here as the Appendix. Volume 1 describes the project as a 3-year research program to determine the effectiveness of using space to teach. The research design is quasi experimental using standardized test data on students from Aldrin Elementary School and a District-identified 'control' school, which shall be referred to as 'School B.' Students now in fourth through sixth grades will be compared now (after one year at Aldrin) and tracked at least until the present sixth graders are through the eighth grade. Appropriate statistical tests will be applied to standardized test scores to see if Aldrin students are 'better' than School B students in areas such as: Overall academic performance; Performance in math/science; and Enrollments in math/science in middle school.
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Harvard Education Letter, 2002.
ERIC Educational Resources Information Center
Gordon, David T., Editor
2002-01-01
This document is comprised of the 6 issues in volume 18 of the Harvard Education Letter, a bimonthly newsletter addressing current issues in elementary and secondary education. Articles in this volume include the following: (1) January/February--"Curriculum Access in the Digital Age" (David T. Gordon) and "Using Charters To Improve…
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FLESNews, Volume 4, Numbers 2-4, 1990-91.
ERIC Educational Resources Information Center
Rosenbusch, Marcia H., Ed.
Issues 2-4 of this volume of the newsletter concerning foreign language instruction in elementary schools (FLES) contain articles on theory, classroom practice, instructional materials, class activities, and professional news, including conferences and information on public policy at the federal level. Articles in these issues include the…
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The Ohio Business Teacher, Volume XLIV.
ERIC Educational Resources Information Center
Porreca, Anthony G., Ed.; Cross, Beverly E., Ed.
1984-01-01
This volume of the Ohio Business Teacher contains articles on teaching business education, especially in the secondary schools, although some articles also include information on teaching business-related material to elementary school children and to adults. Eight of the articles concern classroom teaching techniques for the electronic office,…
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English Leadership Quarterly, 2000-2001.
ERIC Educational Resources Information Center
Kiernan, Henry, Ed.
2001-01-01
This 23rd volume of "English Leadership Quarterly" contains articles on topics of interest to those in positions of leadership in departments (elementary, secondary, or college) where English is taught. Each issue focuses on a different theme. Articles in Volume 23 Number 1 are: "Block Scheduling and Student Achievement"…
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Harvard Education Letter, 2001.
ERIC Educational Resources Information Center
Gordon, David, T., Ed.
2001-01-01
This document is comprised of the six issues in volume 17 of the Harvard Education Letter, a bimonthly newsletter addressing current issues in elementary and secondary education. Articles in this volume include the following: (1) January-February--"Charters and Districts: Three Stages in an Often Rocky Relationship" (Kelly) and "'We…
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Project Developmental Continuity Evaluation: Final Report. Appendices to Volume I.
ERIC Educational Resources Information Center
Bond, James T.; And Others
This document provides the appendices for volume 1 of the final evaluation report of Project Developmental Continuity (PDC), a Head Start demonstration project initiated in 1974 to develop program models which enhance children's social competence by fostering developmental continuity from preschool through the early elementary grades.…
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The Harvard Education Letter, 1998.
ERIC Educational Resources Information Center
Graves-Desai, Kelly, Ed.; Eaton, Susan, Ed.; Walser, Nancy, Ed.
1998-01-01
This document is comprised of volume 14 of the Harvard Education Letter, published bimonthly and addressing current issues in elementary and secondary education. Articles in the six issues of this volume include the following: (1) January-February--"Multi-Age Classrooms: An Age-Old Grouping Method Is Still Evolving" (Walser), "Teachers Wanted:…
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English Leadership Quarterly, 2001-2002.
ERIC Educational Resources Information Center
Kiernan, Henry, Ed.; Wilcox, Bonita L., Ed.
2002-01-01
This 24th volume of "English Leadership Quarterly" contains articles on topics of interest to those in positions of leadership in departments (elementary, secondary, or college) where English is taught. Each issue focuses on a different theme. Articles in Volume 24 Number 1 focus on matters of thinking and are: "A New Way of…
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Behavioral Science Elementary Teacher Education Program. Final Report. Volume II.
ERIC Educational Resources Information Center
Michigan State Univ., East Lansing.
Volume II separately details two model components: Scholarly Modes of Knowledge, in which problem-solving techniques and the applicability of subject content to teaching are emphasized, and Professional Use of Knowledge, in which the student translates what he knows about various disciplines and human learning into instructional strategies. Each…
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The Harvard Education Letter, 1995.
ERIC Educational Resources Information Center
Miller, Edward, Ed.
1995-01-01
This document is comprised of volume 11 of the Harvard Education Letter, published bimonthly and addressing current issues in elementary and secondary education. Articles in the volume's six issues are: (1) January-February--"The Old Model of Staff Development Survives in a World Where Everything Else Has Changed" (Miller), "Giving Voice to Our…
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Harvard Education Letter, 2000.
ERIC Educational Resources Information Center
Gordon, David T., Ed.
2000-01-01
This document is comprised of the six issues in volume 16 of the Harvard Education Letter, a bimonthly newsletter addressing current issues in elementary and secondary education. Articles in this volume include the following: (1) January-February--"Grade Inflation: What's Really behind All Those A's?" (Birk) and "Every Friday was Fight Day"…
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The Journal of the Society for Accelerative Learning and Teaching. Volume 15, 1990.
ERIC Educational Resources Information Center
Journal of the Society for Accelerative Learning and Teaching, 1990
1990-01-01
Articles in this volume of the Journal of the Society for Accelerative Learning and Teaching (SALT) include the following: "Accelerated Learning Components in Elementary Classrooms"; "Ball-Stick Bird: Teaching with the Story Engram"; "A SALT Pilot Study in College Developmental Mathematics"; "Black Education in…
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ERIC Educational Resources Information Center
Peterson, Robert O. H.
This document describes a four-year program designed to develop and test a method for teaching standard English to nonstandard dialect speakers in the first four grades of elementary school in Hilo, Hawaii. Chapters in this first volume are (1) Introduction, (2) Project Site and Evaluation Strategy, (3) Instrumentation, (4) Development of Lesson…
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Crosstalk: The Journal of Defense Software Engineering. Volume 18, Number 1
2005-01-01
d o t . o r g / a s k slashdot/04/04/12/1757244.shtml>. 5. Dibona , C., et al. Open Sources: Voices From the Open Source Rev- olution. 1st ed. O’Reilly...Volume 18, Number 1, January 2005 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER...5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) OO-ALC/MASE,6022 Fir Ave,Hill AFB,UT,84056-5820 8. PERFORMING
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NASA Technical Reports Server (NTRS)
Prajous, R.; Mazankine, J.; Ippolito, J. C.
1978-01-01
Methods and algorithms used for the simulation of elementary power conditioning units buck, boost, and buck-boost, as well as shunt PWM are described. Definitions are given of similar converters and reduced parameters. The various parts of the simulation to be carried out are dealt with; local stability, corrective network, measurements of input-output impedance and global stability. A simulation example is given.
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Thermodynamics of Supercooled and Glassy Water
NASA Astrophysics Data System (ADS)
Debenedetti, Pablo G.
1998-03-01
The behavior of metastable water at low temperatures is unusual. The isothermal compressibility, the isobaric heat capacity, and the magnitude of the thermal expansion coefficient increase sharply upon supercooling, and structural relaxation becomes extremely sluggish at temperatures far above the glass transition(Angell, C.A., Annu. Rev. Phys. Chem., 34, 593, 1983)(Debenedetti, P.G., Metastable Liquids. Concepts and Principles, Princeton University Press, 1996). Water has two distinct glassy phases, low- and high-density amorphous ice (LDA, HDA). The transition between LDA and HDA is accompanied by sharp volume and enthalpy changes, and appears to be first-order(Mishima, O., L.D.Calvert, and E. Whalley, Nature, 314, 76, 1985)(Mishima, O., J. Chem. Phys., 100, 5910, 1994). The understanding of these observations in terms of an underlying global phase behavior remains incomplete(Speedy, R.J., J. Phys. Chem., 86, 982, 1982)(Poole, P.H., F. Sciortino, U. Essman, and H.E. Stanley, Nature, 360, 324, 1992)(Sastry, S., P.G. Debenedetti, F. Sciortino, and H.E. Stanley, Phys. Rev. E, 53, 6144, 1996)(Tanaka, H., Nature, 380, 328, 1996)(Xie, Y., K.F. Ludwig, G. Morales, D.E. Hare, and C.M. Sorensen, Phys. Rev. Lett., 71, 2050, 1993). Microscopic theories and computer simulations suggest several scenarios that can reproduce some experimental observations. Interesting and novel ideas have resulted from this body of theoretical work, such as the possibility of liquid-liquid immiscibility in a pure substance(Poole, P.H., F.Sciortino, T.Grande, H.E. Stanley, and C.A. Angell, Phys. Rev. Lett., 73, 1632, 1994)(Roberts, C.J., and P.G. Debenedetti, J. Chem. Phys., 105, 658, 1996)(Roberts, C.J., P.G. Debenedetti, and A.Z. Panagiotopoulos, Phys. Rev. Lett., 77, 4386, 1996)(Harrington, S., R. Zhang, P.H. Poole, F. Sciortino, and H.E. Stanley, Phys. Rev. Lett., 78, 2409, 1997). In this talk I will review the experimental facts, discuss their theoretical interpretation, and identify key unanswered questions.
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TOPEX Software Document Series. Volume 5; Rev. 1; TOPEX GDR Processing
NASA Technical Reports Server (NTRS)
Lee, Jeffrey; Lockwood, Dennis; Hancock, David W., III
2003-01-01
This document is a compendium of the WFF TOPEX Software Development Team's knowledge regarding Geophysical Data Record (GDR) Processing. It includes many elements of a requirements document, a software specification document, a software design document, and a user's manual. In the more technical sections, this document assumes the reader is familiar with TOPEX and instrument files.
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NASA Astrophysics Data System (ADS)
Polimeridis, Athanasios G.; Reid, M. T. H.; Jin, Weiliang; Johnson, Steven G.; White, Jacob K.; Rodriguez, Alejandro W.
2015-10-01
We describe a fluctuating volume-current formulation of electromagnetic fluctuations that extends our recent work on heat exchange and Casimir interactions between arbitrarily shaped homogeneous bodies [A. W. Rodriguez, M. T. H. Reid, and S. G. Johnson, Phys. Rev. B 88, 054305 (2013), 10.1103/PhysRevB.88.054305] to situations involving incandescence and luminescence problems, including thermal radiation, heat transfer, Casimir forces, spontaneous emission, fluorescence, and Raman scattering, in inhomogeneous media. Unlike previous scattering formulations based on field and/or surface unknowns, our work exploits powerful techniques from the volume-integral equation (VIE) method, in which electromagnetic scattering is described in terms of volumetric, current unknowns throughout the bodies. The resulting trace formulas (boxed equations) involve products of well-studied VIE matrices and describe power and momentum transfer between objects with spatially varying material properties and fluctuation characteristics. We demonstrate that thanks to the low-rank properties of the associated matrices, these formulas are susceptible to fast-trace computations based on iterative methods, making practical calculations tractable. We apply our techniques to study thermal radiation, heat transfer, and fluorescence in complicated geometries, checking our method against established techniques best suited for homogeneous bodies as well as applying it to obtain predictions of radiation from complex bodies with spatially varying permittivities and/or temperature profiles.
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NASA Astrophysics Data System (ADS)
Towers, J.; van Zyl, B. P.; Kirkby, W.
2015-08-01
In a recent paper [B. P. van Zyl et al., Phys. Rev. A 89, 022503 (2014), 10.1103/PhysRevA.89.022503], the average density approximation (ADA) was implemented to develop a parameter-free, nonlocal kinetic energy functional to be used in the orbital-free density functional theory of an inhomogeneous, two-dimensional (2D) Fermi gas. In this work, we provide a detailed comparison of self-consistent calculations within the ADA with the exact results of the Kohn-Sham density functional theory and the elementary Thomas-Fermi (TF) approximation. We demonstrate that the ADA for the 2D kinetic energy functional works very well under a wide variety of confinement potentials, even for relatively small particle numbers. Remarkably, the TF approximation for the kinetic energy functional, without any gradient corrections, also yields good agreement with the exact kinetic energy for all confining potentials considered, although at the expense of the spatial and kinetic energy densities exhibiting poor pointwise agreement, particularly near the TF radius. Our findings illustrate that the ADA kinetic energy functional yields accurate results for both the local and global equilibrium properties of an inhomogeneous 2D Fermi gas, without the need for any fitting parameters.
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Role of pressure anisotropy on relativistic compact stars
NASA Astrophysics Data System (ADS)
Maurya, S. K.; Banerjee, Ayan; Hansraj, Sudan
2018-02-01
We investigate a compact spherically symmetric relativistic body with anisotropic particle pressure profiles. The distribution possesses characteristics relevant to modeling compact stars within the framework of general relativity. For this purpose, we consider a spatial metric potential of Korkina and Orlyanskii [Ukr. Phys. J. 36, 885 (1991)] type in order to solve the Einstein field equations. An additional prescription we make is that the pressure anisotropy parameter takes the functional form proposed by Lake [Phys. Rev. D 67, 104015 (2003), 10.1103/PhysRevD.67.104015]. Specifying these two geometric quantities allows for further analysis to be carried out in determining unknown constants and obtaining a limit of the mass-radius diagram, which adequately describes compact strange star candidates like Her X-1 and SMC X-1. Using the anisotropic Tolman-Oppenheimer-Volkoff equations, we explore the hydrostatic equilibrium and the stability of such compact objects. Then, we investigate other physical features of this model, such as the energy conditions, speeds of sound, and compactness of the star, in detail and show that our results satisfy all the required elementary conditions for a physically acceptable stellar model. The results obtained are useful in analyzing the stability of other anisotropic compact objects like white dwarfs, neutron stars, and gravastars.
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Factors determining the average atomic volumes in intermetallic compounds.
Pauling, L
1987-07-01
In formation of an intermetallic compound from the elementary metals there is usually a contraction in volume. Electron transfer leading to the charge states M(+) and M(-) with increase in valence and decrease in volume explains the more than 2-fold range in contraction for different compounds in the same binary system. In a more thorough analysis, the better packing of atoms of different sizes also needs to be considered.
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ERIC Educational Resources Information Center
Wacker, Sally; And Others
The second of two volumes, this document continues the final evaluation report of Project Developmental Continuity (PDC), a Head Start demonstration project initiated in 1974 to develop program models which enhance children's social competence by fostering developmental continuity from preschool through the early elementary grades. In particular,…
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ERIC Educational Resources Information Center
Bond, James T.; And Others
The first of two volumes, this document reports an evaluation of Project Developmental Continuity (PDC), a Head Start demonstration project initiated in 1974 to develop program models which enhance children's social competence by fostering developmental continuity from preschool through the early elementary years. In general, the impact of program…
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Folksong in the Classroom. Volume III, Numbers 1-3, 1982-83.
ERIC Educational Resources Information Center
Scott, John A., Ed.; Seidman, Laurence I., Ed.
1983-01-01
The third volume of a newsletter for integrating folk music appreciation into elementary and secondary social studies, literature, and humanities courses, this publication contains three issues of the newsletter which together provide a compilation of folksongs from various historical periods and cultures. The first issue contains an article on…
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Technical Reports (Part I). End of Project Report, 1968-1971, Volume III.
ERIC Educational Resources Information Center
Western Nevada Regional Education Center, Lovelock.
The pamphlets included in this volume are technical reports prepared as outgrowths of the Student Information Systems of the Western Nevada Regional Education Center (WN-REC) funded by a Title III (Elementary and Secondary Education Act) grant. These reports describe methods of interpreting the printouts from the Student Information System;…
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Environmental Learning Experiences for Kindergarten Through Second Grade.
ERIC Educational Resources Information Center
Willoughby-Eastlake School District, Willoughby, OH.
This collection of teaching units is one of three volumes designed to assist teachers in bringing relevant, interdisciplinary, environmental learning experiences to elementary students. This first volume is aimed at the K-2 level and deals with the immediate environment of the student. Titles of the nine units presented are: Preparing for Seasonal…
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ERIC Educational Resources Information Center
Vivona, Carol; And Others
Since a large number of the pupils at each of the three schools examined in this document had shown a need for compensatory services, they were classified as Title I schools and thus were qualified to receive supplementary funds and additional personnel through Title I, 1965 Elementary and Secondary Education Act grant allocations. In addition,…
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ERIC Educational Resources Information Center
Willis, Pat; Lauchner, Jan
Federal funds authorized under Title I of the Elementary and Secondary Education Act of 1965 and Title IV-A of the 1967 Amendments to the Social Security Act provided compensatory programs and family services. The English-Reading Activity under Title I consisted of intensive reading instruction and health-medical services for the lowest achievers.…
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Far-field Measurement of Ultra-Small Plasmonic Mode Volume
2010-03-15
Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 18. M. L. Povinelli , S. G. Johnson, M. Lonèar, M. Ibanescu, E. J. Smythe, F. Capasso, and J. D...8286–8295 (2005). 19. M. L. Povinelli , M. Loncar, M. Ibanescu, E. J. Smythe, S. G. Johnson, F. Capasso, and J. D. Joannopoulos, “Evanescent-wave
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Factors determining the average atomic volumes in intermetallic compounds
Pauling, Linus
1987-01-01
In formation of an intermetallic compound from the elementary metals there is usually a contraction in volume. Electron transfer leading to the charge states M+ and M- with increase in valence and decrease in volume explains the more than 2-fold range in contraction for different compounds in the same binary system. In a more thorough analysis, the better packing of atoms of different sizes also needs to be considered. PMID:16578809
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History Textbooks at the New Century: A Report of the American Textbook Council.
ERIC Educational Resources Information Center
Sewall, Gilbert T.
The American Textbook Council identified the nation's leading social studies textbooks based on estimated volume of sales and on adoptions in California, Indiana, North Carolina, Florida, and New York. Three multi-volume elementary-level programs and about a dozen secondary-level history textbooks command the market. The history textbooks at the…
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Environmental Learning Experiences for Grades Five and Six.
ERIC Educational Resources Information Center
Willoughby-Eastlake School District, Willoughby, OH.
The third of this series of three volumes on interdisciplinary environmental learning experiences for elementary students is aimed at grades 5 and 6 and deals with the comunity environment of the student. Titles of the eight units included in this volume are: Probleem Solving; How to Plan a Clean-up Campaign in the Local Community; Scars upon the…
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Language Arts for Today's Children. NCTE Curriculum Series, Volume Two.
ERIC Educational Resources Information Center
National Council of Teachers of English, Champaign, IL. Commission on the English Curriculum.
This volume on elementary language programs is divided into four related parts. Part 1 discusses the sources of any effective language program: an understanding of the child's need for language, a knowledge of child development, and an awareness of the continuity essential to growth in language. Part 2 treats the main areas of the language…
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Teaching about Colorado and Community History. History Series, Volume 1.
ERIC Educational Resources Information Center
Smith, Gary R.
This volume is designed to supplement materials teachers have chosen to use in teaching Colorado and community history. The materials are not a complete history of Colorado or a complete textbook; instead, teachers are provided with 14 teaching activities for use in elementary and secondary social studies or history classes. The book is divided…
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Technical Reports (Part II). End of Project Report, 1968-1971, Volume IV.
ERIC Educational Resources Information Center
Western Nevada Regional Education Center, Lovelock.
The pamphlets included in this volume are technical reports prepared as outgrowths of the Student Information System of the Western Nevada Regional Education Center funded by a Title III grant under the Elementary and Secondary Education Act of 1965. These reports demonstrate the use of the stored data; methods of interpreting the printouts from…
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A Curriculum Activities Guide to Solid Wastes and Environmental Studies, Volume 4.
ERIC Educational Resources Information Center
Hershey, John T., Ed.; And Others
This document, developed for elementary and secondary students, is one of a series emphasizing student-oriented problem solving related to environmental matters. It is designed to guide others in initiating, continuing, or expanding their environmental education program. Volume 4 is intended for use by cadre who have used similar materials at a…
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ESEA Title I Evaluation Report, 1973-74, Volume 2.
ERIC Educational Resources Information Center
Saint Louis Public Schools, MO.
Volume II of the St. Louis Public Schools evaluation report on programs, projects, services, and activities funded in whole or in part under Elementary Secondary Education Act Title I is organized into two parts, each focusing on one component. Component Five, 'Non-public Schools, services and projects' serviced 18 Catholic and 5 Lutheran schools.…
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ERIC Educational Resources Information Center
Prunty, John J.; And Others
This third volume of a six-volume study of a school district code-named "Milford" shifts attention to the Kensington School itself. To explain the "profound changes" this "once innovative school" went through, the authors begin with such wider topics as demography, neighborhoods, and political jurisdiction. Chapter 1 traces Milford's "Native…
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ERIC Educational Resources Information Center
Congress of the U.S., Washington, DC. House Committee on Education and Labor.
These statements, letters, and supplemental materials were provided by: (1) Janet Jones Ballard, Assault on Literacy Program; (2) Representative Jim Cooper, Tennessee; (3) Mitch Snyder, Center for Creative Non-Violence; (4) Garrett Murphy, Division of Adult and Continuing Education Programs, New York; (5) W. Wilson Goode, mayor of Philadelphia;…
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Final Report on Contract F49620-85-C-0026. Volume 1.
1987-05-01
RFOSR-TR-S?-1349-VOL-1 UNCLMSSIFIED F40-BS-C46F/ 20/4 L E.EEEEEEEEE.E. 0 0 ’El..... oso - ~L.0 3 111IL25 . MJCROC(OP RESOLUTION TEST CHARI WiloUiAl SURIAU...Yakhot, R. Panda , U. Frisch, and R.H. Kraichnan, Weak Interactions and Local Order in Strong Turbulence, Phys. Rev. Let. (1986) submitted. -3- V. Yakhot
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Atmospheric Renewable Energy Research, Volume 5 (Solar Radiation Flux Model)
2017-09-01
Approved for public release; distribution is unlimited. ii REPORT DOCUMENTATION PAGE Form Approved OMB No... FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) September 2017 2. REPORT TYPE Technical Report 3. DATES COVERED (From - To) 2017 June 01...3237 Standard Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 Approved for public release; distribution is unlimited. iii Contents List
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ERIC Educational Resources Information Center
Houston Univ., TX. Energy Inst.
This publication is a systematic listing of energy education materials and reference sources suitable for use in elementary and secondary schools. Items in this volume, located through computer searches, were still available in May, 1978. This inventory of energy resource materials consists of three indexes: media, grade level, and subject. Each…
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ERIC Educational Resources Information Center
Allen, Rodney F.
As part of the series of student materials developed by the Environmental Education Project at Florida State University, this volume contains three instructional units on urban environment. Designed for upper-elementary and secondary students, the materials require only low-level reading abilities while insisting on high-level participation. The…
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ERIC Educational Resources Information Center
Marvis, Barbara J.
The biographies in this projected eight volume series for elementary school children represent the diversity of Hispanic heritage in the United States. Those featured are contemporary figures with national origins in the United States or Latin America, with careers that cover many aspects of contemporary life. Every person profiled in the series…
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ERIC Educational Resources Information Center
Policy Studies Associates, Inc., Washington, DC.
The Title I program, the federal government's largest elementary and secondary school program, has been redesigned in order to make improvements in the nation's poorest schools. This handbook comprises the first of two volumes that provide examples of schools and communities working together to provide children with more time to learn. The book…
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Folksong in the Classroom. Volume XI, Numbers 1-3, 1990-91.
ERIC Educational Resources Information Center
Scott, John W., Ed.
1991-01-01
This volume of a journal on folksong for elementary and secondary teachers of history, literature, music, and the humanities contains three issues. The Fall 1990 issue is devoted to the songs of Newfoundland. The Winter 1991 issue features songs concerning mine, mill and tunnel workers in the years 1877-1932. The Spring 1991 issue focuses on songs…
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Vassal, J-P; Orgéas, L; Favier, D; Auriault, J-L; Le Corre, S
2008-01-01
Many analytical and numerical works have been devoted to the prediction of macroscopic effective transport properties in particulate media. Usually, structure and properties of macroscopic balance and constitutive equations are stated a priori. In this paper, the upscaling of the transient diffusion equations in concentrated particulate media with possible particle-particle interfacial barriers, highly conductive particles, poorly conductive matrix, and temperature-dependent physical properties is revisited using the homogenization method based on multiple scale asymptotic expansions. This method uses no a priori assumptions on the physics at the macroscale. For the considered physics and microstructures and depending on the order of magnitude of dimensionless Biot and Fourier numbers, it is shown that some situations cannot be homogenized. For other situations, three different macroscopic models are identified, depending on the quality of particle-particle contacts. They are one-phase media, following the standard heat equation and Fourier's law. Calculations of the effective conductivity tensor and heat capacity are proved to be uncoupled. Linear and steady state continuous localization problems must be solved on representative elementary volumes to compute the effective conductivity tensors for the two first models. For the third model, i.e., for highly resistive contacts, the localization problem becomes simpler and discrete whatever the shape of particles. In paper II [Vassal, Phys. Rev. E 77, 011303 (2008)], diffusion through networks of slender, wavy, entangled, and oriented fibers is considered. Discrete localization problems can then be obtained for all models, as well as semianalytical or fully analytical expressions of the corresponding effective conductivity tensors.
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NASA Astrophysics Data System (ADS)
Scherer, Artur; Valiron, Benoît; Mau, Siun-Chuon; Alexander, Scott; van den Berg, Eric; Chapuran, Thomas E.
2017-03-01
We provide a detailed estimate for the logical resource requirements of the quantum linear-system algorithm (Harrow et al. in Phys Rev Lett 103:150502, 2009) including the recently described elaborations and application to computing the electromagnetic scattering cross section of a metallic target (Clader et al. in Phys Rev Lett 110:250504, 2013). Our resource estimates are based on the standard quantum-circuit model of quantum computation; they comprise circuit width (related to parallelism), circuit depth (total number of steps), the number of qubits and ancilla qubits employed, and the overall number of elementary quantum gate operations as well as more specific gate counts for each elementary fault-tolerant gate from the standard set { X, Y, Z, H, S, T, { CNOT } }. In order to perform these estimates, we used an approach that combines manual analysis with automated estimates generated via the Quipper quantum programming language and compiler. Our estimates pertain to the explicit example problem size N=332{,}020{,}680 beyond which, according to a crude big-O complexity comparison, the quantum linear-system algorithm is expected to run faster than the best known classical linear-system solving algorithm. For this problem size, a desired calculation accuracy ɛ =0.01 requires an approximate circuit width 340 and circuit depth of order 10^{25} if oracle costs are excluded, and a circuit width and circuit depth of order 10^8 and 10^{29}, respectively, if the resource requirements of oracles are included, indicating that the commonly ignored oracle resources are considerable. In addition to providing detailed logical resource estimates, it is also the purpose of this paper to demonstrate explicitly (using a fine-grained approach rather than relying on coarse big-O asymptotic approximations) how these impressively large numbers arise with an actual circuit implementation of a quantum algorithm. While our estimates may prove to be conservative as more efficient advanced quantum-computation techniques are developed, they nevertheless provide a valid baseline for research targeting a reduction of the algorithmic-level resource requirements, implying that a reduction by many orders of magnitude is necessary for the algorithm to become practical.
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No-migration variance petition. Appendices A--B: Volume 2, Revision 1
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1990-03-01
Volume II contains Appendix A, emergency plan and Appendix B, waste analysis plan. The Waste Isolation Pilot Plant (WIPP) Emergency plan and Procedures (WP 12-9, Rev. 5, 1989) provides an organized plan of action for dealing with emergencies at the WIPP. A contingency plan is included which is in compliance with 40 CFR Part 265, Subpart D. The waste analysis plan provides a description of the chemical and physical characteristics of the wastes to be emplaced in the WIPP underground facility. A detailed discussion of the WIPP Waste Acceptance Criteria and the rationale for its established units are also included.
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X-ray CT analysis of pore structure in sand
NASA Astrophysics Data System (ADS)
Mukunoki, Toshifumi; Miyata, Yoshihisa; Mikami, Kazuaki; Shiota, Erika
2016-06-01
The development of microfocused X-ray computed tomography (CT) devices enables digital imaging analysis at the pore scale. The applications of these devices are diverse in soil mechanics, geotechnical and geoenvironmental engineering, petroleum engineering, and agricultural engineering. In particular, the imaging of the pore space in porous media has contributed to numerical simulations for single-phase and multiphase flows or contaminant transport through the pore structure as three-dimensional image data. These obtained results are affected by the pore diameter; therefore, it is necessary to verify the image preprocessing for the image analysis and to validate the pore diameters obtained from the CT image data. Moreover, it is meaningful to produce the physical parameters in a representative element volume (REV) and significant to define the dimension of the REV. This paper describes the underlying method of image processing and analysis and discusses the physical properties of Toyoura sand for the verification of the image analysis based on the definition of the REV. On the basis of the obtained verification results, a pore-diameter analysis can be conducted and validated by a comparison with the experimental work and image analysis. The pore diameter is deduced from Young-Laplace's law and a water retention test for the drainage process. The results from previous study and perforated-pore diameter originally proposed in this study, called the voxel-percolation method (VPM), are compared in this paper. In addition, the limitations of the REV, the definition of the pore diameter, and the effectiveness of the VPM for an assessment of the pore diameter are discussed.
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Systems Book for a Student Information System. End of Project Report, 1968-1971, Volume II.
ERIC Educational Resources Information Center
Western Nevada Regional Education Center, Lovelock.
The necessary handbooks for use of the Student Information System (SIS), developed and tested by the Western Nevada Regional Education Center under a 1968-71 Title III (Elementary and Secondary Education Act) grant, are presented in this volume. As noted, the purpose of the SIS is to supply data and information to persons or organizations who make…
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ERIC Educational Resources Information Center
Woo, Jeong-Ho, Ed.; Lew, Hee-Chan, Ed.; Park, Kyo-Sik Park, Ed.; Seo, Dong-Yeop, Ed.
2007-01-01
This third volume of the 31st annual proceedings of the International Group for the Psychology of Mathematics Education conference presents research reports for author surnames beginning Han- through Miy-. Reports include: (1) Elementary Education Students' Memories of Mathematics in Family Context (Markku S. Hannula, Raimo Kaasila, Erkki…
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A Guide to the Use of Street/Folk/Musical Games in the Classroom. Volume I, Song-Games.
ERIC Educational Resources Information Center
Hillery, Mable A.; Simmons, Patricia M.
This teaching guide is the first of three volumes designed to teach Afro-American children street/folk/musical games in the elementary classroom. It is one of the Interdependent Learning Models (ILM) whose overall objective is for teachers to use the cultures of their students as vehicles for teaching academic skills and content. This volume…
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Quantum Monte Carlo calculations of NiO
NASA Astrophysics Data System (ADS)
Maezono, Ryo; Towler, Mike D.; Needs, Richard. J.
2008-03-01
We describe variational and diffusion quantum Monte Carlo (VMC and DMC) calculations [1] of NiO using a 1024-electron simulation cell. We have used a smooth, norm-conserving, Dirac-Fock pseudopotential [2] in our work. Our trial wave functions were of Slater-Jastrow form, containing orbitals generated in Gaussian-basis UHF periodic calculations. Jastrow factor is optimized using variance minimization with optimized cutoff lengths using the same scheme as our previous work. [4] We apply the lattice regulated scheme [5] to evaluate non-local pseudopotentials in DMC and find the scheme improves the smoothness of the energy-volume curve. [1] CASINO ver.2.1 User Manual, University of Cambridge (2007). [2] J.R. Trail et.al., J. Chem. Phys. 122, 014112 (2005). [3] CRYSTAL98 User's Manual, University of Torino (1998). [4] Ryo Maezono et.al., Phys. Rev. Lett., 98, 025701 (2007). [5] Michele Casula, Phys. Rev. B 74, 161102R (2006).
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Collins Center Update. Volume 16, Issue 4, July-September 2014
2014-09-01
OF RESPONSIBLE PERSON a REPORT unclassified b ABSTRACT unclassified c THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by...ANSI Std Z39-18 2 C S L D The USAWC SBP consisted of five weeks of instruction that included core strategic studies instruction, a capstone... Knott and Mr. Kevin Dixon (Strategic Outreach Division) provided battlefield staff rides to Antietam and Gettysburg, exploring insights on the
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Air and Space Power Journal. Volume 24, Number 1, Spring 2010
2010-01-01
unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 SP IN E http...messen- gers to conduct psychological operations (PSYOP). EW operations seek to achieve ef- fects across the electromagnetic domain, including radio...a man made virtual domain. Further study reveals its natural similarities to the other domains, as defined by the electromagnetic spectrum
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Generalized network modeling of capillary-dominated two-phase flow
NASA Astrophysics Data System (ADS)
Raeini, Ali Q.; Bijeljic, Branko; Blunt, Martin J.
2018-02-01
We present a generalized network model for simulating capillary-dominated two-phase flow through porous media at the pore scale. Three-dimensional images of the pore space are discretized using a generalized network—described in a companion paper [A. Q. Raeini, B. Bijeljic, and M. J. Blunt, Phys. Rev. E 96, 013312 (2017), 10.1103/PhysRevE.96.013312]—which comprises pores that are divided into smaller elements called half-throats and subsequently into corners. Half-throats define the connectivity of the network at the coarsest level, connecting each pore to half-throats of its neighboring pores from their narrower ends, while corners define the connectivity of pore crevices. The corners are discretized at different levels for accurate calculation of entry pressures, fluid volumes, and flow conductivities that are obtained using direct simulation of flow on the underlying image. This paper discusses the two-phase flow model that is used to compute the averaged flow properties of the generalized network, including relative permeability and capillary pressure. We validate the model using direct finite-volume two-phase flow simulations on synthetic geometries, and then present a comparison of the model predictions with a conventional pore-network model and experimental measurements of relative permeability in the literature.
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ERIC Educational Resources Information Center
School Science Review, 1984
1984-01-01
Presents (1) suggestions on teaching volume and density in the elementary school; (2) ideas for teaching about floating and sinking; (3) a simple computer program on color addition; and (4) an illustration of Newton's second law of motion. (JN)
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Parr, S L; Chung, K Y; Hutcheson, J P; Nichols, W T; Yates, D A; Streeter, M N; Swingle, R S; Galyean, M L; Johnson, B J
2011-03-01
Four experiments evaluated the effect of implant dose and release pattern on performance and carcass traits of crossbred beef steers. In Exp. 1, steers (4 to 7 pens/treatment; initial BW = 315 kg) were fed an average of 174 d. Treatments were 1) no implant (NI); 2) Revalor-S [120 mg of trenbolone acetate (TBA) and 24 mg of estradiol 17β (E(2)); REV-S]; 3) Revalor-IS followed by REV-S (cumulatively 200 mg of TBA and 40 mg of E(2); reimplanted at 68 to 74 d; REV-IS/S); and 4) Revalor-XS (200 mg of TBA and 40 mg of E(2); REV-X). Carcass-adjusted final BW was greater (P < 0.05) for REV-X and REV-IS/S than for REV-S (610, 609, and 598 kg, respectively). Daily DMI did not differ (P > 0.10) among the 3 implants, but carcass-adjusted G:F was greater (P < 0.05) for REV-X and REV-IS/S than for REV-S (0.197 and 0.195 vs. 0.188). Both HCW and LM area were greater (P < 0.05) for REV-X and REV-IS/S than for REV-S. Marbling scores were greatest (P < 0.05) for REV-S and least (P < 0.05) for REV-IS/S; REV-X was intermediate to NI and REV-IS/S. In Exp. 2, steers (10 pens/treatment; initial BW = 391 kg) were fed 131 d, with treatments of REV-S, REV-IS/S (reimplanted at 44 to 47 d), and REV-X. Carcass-adjusted final BW (598 kg), ADG (1.6 kg), DMI (9.4 kg), G:F (0.17), and HCW did not differ (P > 0.10) among treatments. The percentage of Choice was less (P < 0.05) and percentage of Select greater (P < 0.05) for REV-IS/S than for REV-S and REV-X. In Exp. 3, steers (10 pens/treatment; initial BW = 277 kg) were fed 197 d and received either REV-IS/S (reimplanted at 90 to 103 d) or REV-X. Carcass-adjusted final BW (625 vs. 633 kg) and ADG (1.81 vs. 1.76 kg) were greater (P < 0.05) for REV-X-implanted steers. Daily DMI did not differ, but G:F tended (P < 0.10) to be increased and HCW was greater (P < 0.05) for REV-X than for REV-IS/S. In Exp. 4, steers (8 pens/treatment; initial BW = 238 kg) were fed 243 d and received either REV-IS/S (reimplanted at 68 to 71 d) or REV-X. Carcass-adjusted final BW (612 kg), ADG (1.54 kg), DMI (7.55), and G:F (0.21) did not differ (P > 0.10) for REV-IS/S and REV-X-implanted steers. Carcass traits did not differ among implants, but the percentage of Choice carcasses was greater (P < 0.05) and percentage of Select was less (P < 0.05) for REV-X than for REV-IS/S. These data indicate that when TBA/E(2) dose is equal, the altered release rate of REV-X can improve performance and quality grade, but these effects depend on duration of the feeding period and timing of initial and terminal implants.
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Local probing by use of transparent model materials
NASA Astrophysics Data System (ADS)
Philippe, P.
2017-12-01
The present contribution emphasizes on two distinct examples the benefit with using transparent materials that enable direct visualization within different types of model systems. Our first use of transparent materials investigates the elementary mechanisms involved in soil erosion based on three key ingredients: a) cohesive model materials (i.e. glass beads bonded by solid bridges); b) optical techniques (Refractive Index Matching and Planar Laser Induced Fluorescence [1,2]) ; c) specific mechanical tests to estimate the mechanical strength of the solid bonds. Then, critical shear-stress at erosion onset can be related to tensile strength considering an extension of the classical Shields' number [3,4].Our second example uses a transparent elasto-visco-plastic fluid (Carbopol) as a model of debris flows. Different geometrical configurations allow for an accurate investigation of the flow over an obstacle [5] or a cavity [6], inducing the existence of a dead-zone and consequently of a frontier between solid-like and fluid-like regions that is of particular relevance for debris flows mobilization and deposition. Practically, the hydrodynamics of the flow is investigated by means of high-resolution optical velocimetry (PIV) and underlines a non-monotonous evolution of the shear rate, which increases from zero at the solid-liquid interface, passes through a peak (sometimes leveling off at its maximum value), and returns to zero in a plug zone sufficiently far above the cavity or the obstacle. [1] Philippe P., and Badiane M. Phys. Rev. E 87, 042206 (2013). [2] Dijksman J.A., Rietz F., Lorincz K.A., van Hecke M., and Losert W. Review of Scientific Instruments 83(1), 011301 (2012). [3] Badr S., Gauthier G., and Gondret P. Phys. Fluids 26:023302 (2014). [4] Brunier-Coulin F., Cuéllar P., and Philippe P. Phys. Rev. Fluids 87, 2: 034302 (2017). [5] Luu L.-H., Philippe P., and Chambon G. Phys. Rev. E 91, 013013 (2015). [6] Luu L.-H., Philippe P.; and Chambon G. Journal of Non-Newtonian Fluid Mechanics 245, 25-37 (2017).
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Experimental demonstration of entanglement-assisted coding using a two-mode squeezed vacuum state
NASA Astrophysics Data System (ADS)
Mizuno, Jun; Wakui, Kentaro; Furusawa, Akira; Sasaki, Masahide
2005-01-01
We have experimentally realized the scheme initially proposed as quantum dense coding with continuous variables [
Ban, J. Opt. B: Quantum Semiclassical Opt. 1, L9 (1999) ;Braunstein and Kimble, Phys. Rev. A 61, 042302 (2000) ]. In our experiment, a pair of EPR (Einstein-Podolsky-Rosen) beams is generated from two independent squeezed vacua. After adding a two-quadrature signal to one of the EPR beams, two squeezed beams that contain the signal were recovered. Although our squeezing level is not sufficient to demonstrate the channel capacity gain over the Holevo limit of a single-mode channel without entanglement, our channel is superior to conventional channels such as coherent and squeezing channels. In addition, the optical addition and subtraction processes demonstrated are elementary operations of universal quantum information processing on continuous variables. -
Framing Prospective Elementary Teachers' Conceptions of Dissolving as a Ladder of Explanations
NASA Astrophysics Data System (ADS)
Subramaniam, Karthigeyan; Esprivalo Harrell, Pamela
2013-11-01
The paper details an exploratory qualitative study that investigated 61 prospective teachers' conceptual understanding of dissolving salt and sugar in water respectively. The study was set within a 15-week elementary science methods course that included a 5E learning cycle lesson on dissolving, the instructional context. Oversby's (Prim Sci Rev 63:6-19, 2002, Aspects of teaching secondary science, Routledge Falmer, London, 2002) ladder of explanations for the context of dissolving, current scientific explanations for dissolving and perspectives on conceptions and misconceptions provided the unified framework for the study. Concept maps, interview transcripts, written artifacts, and drawings and narratives were used as data to investigate these prospective teachers' conceptual understanding of dissolving throughout the 15-weeks of the methods course. Analysis revealed that participants' explanations of dissolving were predominantly descriptive explanations (39 %) and interpretative explanations (38 %), with lower percentage occurrences of intentional (14 %) and cause and effect (9 %) level explanations. Most of these explanations were also constructed by a set of loosely connected and reinforcing everyday concepts abstracted from common everyday experiences making them misconceptions. Implications include: (1) the need for science teacher educators to use multiple platforms to derive their prospective elementary teachers' conceptual understandings of science content; and (2) to identify and help them identify their own scientific conceptions and misconceptions and how they influence the construction of scientific/nonscientific explanations. Science teacher educators also need to emphasize the role of meaningful frameworks associated with the concept that is being introduced during the Engage phase of the 5E learning cycle. This is important because, relevant prior knowledge is associated with the knowledge of the particle theory of matter and both are part of larger knowledge system comprised of interrelated scientific concepts.
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Scaling analyses of the spectral dimension in 3-dimensional causal dynamical triangulations
NASA Astrophysics Data System (ADS)
Cooperman, Joshua H.
2018-05-01
The spectral dimension measures the dimensionality of a space as witnessed by a diffusing random walker. Within the causal dynamical triangulations approach to the quantization of gravity (Ambjørn et al 2000 Phys. Rev. Lett. 85 347, 2001 Nucl. Phys. B 610 347, 1998 Nucl. Phys. B 536 407), the spectral dimension exhibits novel scale-dependent dynamics: reducing towards a value near 2 on sufficiently small scales, matching closely the topological dimension on intermediate scales, and decaying in the presence of positive curvature on sufficiently large scales (Ambjørn et al 2005 Phys. Rev. Lett. 95 171301, Ambjørn et al 2005 Phys. Rev. D 72 064014, Benedetti and Henson 2009 Phys. Rev. D 80 124036, Cooperman 2014 Phys. Rev. D 90 124053, Cooperman et al 2017 Class. Quantum Grav. 34 115008, Coumbe and Jurkiewicz 2015 J. High Energy Phys. JHEP03(2015)151, Kommu 2012 Class. Quantum Grav. 29 105003). I report the first comprehensive scaling analysis of the small-to-intermediate scale spectral dimension for the test case of the causal dynamical triangulations of 3-dimensional Einstein gravity. I find that the spectral dimension scales trivially with the diffusion constant. I find that the spectral dimension is completely finite in the infinite volume limit, and I argue that its maximal value is exactly consistent with the topological dimension of 3 in this limit. I find that the spectral dimension reduces further towards a value near 2 as this case’s bare coupling approaches its phase transition, and I present evidence against the conjecture that the bare coupling simply sets the overall scale of the quantum geometry (Ambjørn et al 2001 Phys. Rev. D 64 044011). On the basis of these findings, I advance a tentative physical explanation for the dynamical reduction of the spectral dimension observed within causal dynamical triangulations: branched polymeric quantum geometry on sufficiently small scales. My analyses should facilitate attempts to employ the spectral dimension as a physical observable with which to delineate renormalization group trajectories in the hope of taking a continuum limit of causal dynamical triangulations at a nontrivial ultraviolet fixed point (Ambjørn et al 2016 Phys. Rev. D 93 104032, 2014 Class. Quantum Grav. 31 165003, Cooperman 2016 Gen. Relativ. Gravit. 48 1, Cooperman 2016 arXiv:1604.01798, Coumbe and Jurkiewicz 2015 J. High Energy Phys. JHEP03(2015)151).
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ERIC Educational Resources Information Center
Bockman, John F.
Volume I contains the substance of five studies originally filed with the United States District Court for the District of Arizona in the cases of "Fisher v. Lohr" and "Mendoza v. Tucson School District No. 1." Study I determines patterns of attendance at several elementary schools by non-Mexican American and Mexican American…
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Medical Surveillance Monthly Report (MSMR). Volume 1, Number 3, June 1995
1995-06-01
Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 MSMR2 June, 1995 Executive Editor COL John F. Brundage, MD, MPH Director, Epidemiology ...neces- sarily those of the Department of the Army. Prepared by the Medical Surveil- lance Activity, Directorate of Epidemiology and Disease...Gonorrhea Herpes Simplex Syphilis Prim/Sec Syphilis Latent Urethritis non-spec. Other STDs** MTF/Post** Cur. Cum. Cur. Cum. Cur. Cum. Cur. Cum. Cur
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Space Propulsion Hazards Analysis Manual (SPHAM). Volume 1
1988-10-01
Wiley, New York, 1983, p.p. 64-68 (11) Martin Marietta MCR 82-800, Rev. B, 29 September 1982, "DOD Safety Review Team Lessons Learned Data Base...FLinaIRe-p,.-t, Martin Marietta Technical Report , Contract F42600-81-D-1379, September 1982. (57) Bader, Donaldson, et. al., Liquid Propellant Rocket Abort...Fire Model, Journal of Astronautics and Aeronautics, December 1971. (58) Banning, D., Propellant_$pill Analysi, Martin Marietta Technical Report , July
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Atmospheric Renewable Energy Research, Volume 3: Solar-Power Microgrids and Atmospheric Influences
2016-09-01
Approved for public release; distribution unlimited. ii REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 Public reporting...with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1...code) 575-678-3237 Standard Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 Approved for public release; distribution is unlimited. iii
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Retention capacity of correlated surfaces.
Schrenk, K J; Araújo, N A M; Ziff, R M; Herrmann, H J
2014-06-01
We extend the water retention model [C. L. Knecht et al., Phys. Rev. Lett. 108, 045703 (2012)] to correlated random surfaces. We find that the retention capacity of discrete random landscapes is strongly affected by spatial correlations among the heights. This phenomenon is related to the emergence of power-law scaling in the lake volume distribution. We also solve the uncorrelated case exactly for a small lattice and present bounds on the retention of uncorrelated landscapes.
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International Law Studies. The War in Iraq: A Legal Analysis. Violume 86
2010-01-01
AND ADDRESS(ES) Naval War College,International Law Studies ,686 Cushing Road ,Newport,RI,02841-1207 8. PERFORMING ORGANIZATION REPORT NUMBER 9...ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 International Law Studies Volume...INTERNATIONAL LAW STUDIES SERIES PRESIDENT, NAVAL WAR COLLEGE Rear Admiral James P. Wisecup, USN PROVOST, NAVAL WAR COLLEGE Ambassador Mary Ann Peters (Ret
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CTC Sentinel. Volume 5, Issue 4, April 2012
2012-04-01
Rev. 8-98) Prescribed by ANSI Std Z39-18 2 This article asserts that the FSA is foremost a national liberation movement determined to overthrow...al-Assad to grant him support, and kept the conflict a highly asymmetrical one as the outgunned FSA continues to battle well-armed, pro -regime...mil i t iamen. 16 A pro -FSA humanitarian logist ician claimed that non-lethal Iranian materiel used to suppress demonstrators was being offloaded
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Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.
Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M
2017-02-01
HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide, thereby biasing its trafficking to and retention within the nucleus. Targeted pharmacological disruption of Rev-Rev interactions should perturb multiple Rev activities, both Rev-RNA binding and Rev's trafficking to the nucleus in the first place. Copyright © 2017 American Society for Microbiology.
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Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export
Behrens, Ryan T.; Aligeti, Mounavya; Pocock, Ginger M.; Higgins, Christina A.
2016-01-01
ABSTRACT HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. IMPORTANCE HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide, thereby biasing its trafficking to and retention within the nucleus. Targeted pharmacological disruption of Rev-Rev interactions should perturb multiple Rev activities, both Rev-RNA binding and Rev's trafficking to the nucleus in the first place. PMID:27852860
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ERIC Educational Resources Information Center
Crain, Robert L., Ed.
This evaluation sampled 150 pairs of schools (50 pairs of high schools and 100 pairs of elementary schools) eligible for ESAP funds, randomly designating one school from each pair as a control school to receive no ESAP funds and using a flip of the coin to so designate. The first volume of the report comprises four chapters and seven appendices.…
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ERIC Educational Resources Information Center
Association for the Development of Computer-based Instructional Systems.
The second of three volumes of papers presented at the 1979 ADCIS convention, this collection includes 37 papers presented to four special interest groups--computer based training, deaf education, elementary/secondary education/junior colleges, and health education. The eight papers on computer based training describe computer graphics, computer…
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ERIC Educational Resources Information Center
Lackney, Jeffery A.
Environmental factors are being increasingly recognized as playing a role in school effectiveness and educational outcomes. Volume 1 examines what is known concerning the diagnosis, design, and management of environmental quality in schools, and the perceived relationship between environmental quality and educational outcomes, as revealed in an…
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NASA Astrophysics Data System (ADS)
Frederiksen, T.; Paulsson, M.; Ueba, H.
2014-01-01
A theory of action spectroscopy, i.e., a reaction rate or yield as a function of bias voltage, is presented for single-molecule reactions induced by the inelastic tunneling current with a scanning tunneling microscope. A formula for the reaction yield is derived using the adsorbate resonance model, which provides a versatile tool to analyze vibrationally mediated reactions of single adsorbates on conductive surfaces. This allows us to determine the energy quantum of the excited vibrational mode, the effective broadening of the vibrational density of states (as described by Gaussian or Lorentzian functions), and a prefactor characterizing the elementary process behind the reaction. The underlying approximations are critically discussed. We point out that observation of reaction yields at both bias voltage polarities can provide additional insight into the adsorbate density of states near the Fermi level. As an example, we apply the theory to the case of flip motion of a hydroxyl dimer (OD)2 on Cu(110) which was experimentally observed by Kumagai et al. [Phys. Rev. B 79, 035423 (2009), 10.1103/PhysRevB.79.035423]. In combination with density functional theory calculations for the vibrational modes, the vibrational damping due to electron-hole pair generation, and the potential energy landscape for the flip motion, a detailed microscopic picture for the switching process is established. This picture reveals that the predominant mechanism is excitation of the OD stretch modes which couple anharmonically to the low-energy frustrated rotation mode.
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Modeling of the Inter-phase Mass Transfer during Cosolvent-Enhanced NAPL Remediation
NASA Astrophysics Data System (ADS)
Agaoglu, B.; Scheytt, T. J.; Copty, N. K.
2012-12-01
This study investigates the factors influencing inter-phase mass transfer during cosolvent-enhanced NAPL remediation and the ability of the REV (Representative Elementary Volume) modeling approach to simulate these processes. The NAPLs considered in this study consist of pure toluene, pure benzene and known mixtures of these two compounds, while ethanol-water mixtures were selected as the remedial flushing solutions. Batch tests were performed to identify both the equilibrium and non-equilibrium properties of the multiphase system. A series of column flushing experiments involving different NAPLs were conducted for different ethanol contents in the flushing solution and for different operational parameters. Experimental results were compared to numerical simulations obtained with the UTCHEM multiphase flow simulator (Delshad et al., 1996). Results indicate that the velocity of the flushing solution is a major parameter influencing the inter-phase mass transport processes at the pore scale. Depending on the NAPL composition and porous medium properties, the remedial solution may follow preferential flow paths and be subject to reduced contact with the NAPL. This leads to a steep decrease in the apparent mass transfer coefficient. Correlations of the apparent time-dependent mass transfer coefficient as a function of flushing velocity are developed for various porous media. Experimental results also show that the NAPL mass transfer coefficient into the cosolvent solution increases when the NAPL phase becomes mobile. This is attributed to the increase in pore scale contact area between NAPL and the remedial solution when NAPL mobilization occurs. These results suggest the need to define a temporal and spatially variable mass transfer coefficient of the NAPL into the cosolvent solution to reflect the occurrence of subscale preferential flow paths and the transient bypassing of the NAPL mass. The implications of these findings on field scale NAPL remediation with cosolvents are discussed.
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Joint Center for Operational Analysis Quarterly Bulletin. Volume 8, Issue 2, June 2006
2006-06-01
aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if...OF PAGES 72 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev...reaches out across the Department of Defense to handle all IED related inquires. As the capability continues to mature and improve, the long term
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Development and Utility of Automatic Language Processing Technologies. Volume 2
2014-04-01
speech for each word using the existing Treetagger program. 3. Stem the word using the revised RevP stemmer, “RussianStemmer2013. java ” (see Section...KBaselineParaphrases2013. java ,” with the paraphrase table and a LM built from the TED training data. Information from the LM was called using the new utility query_interp...GATE/ Java Annotation Patterns Engine (JAPE) interface and on transliteration of Chinese named entities. Available Linguistic Data Consortium (LDC
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1993-10-01
Publications 1986-1992 1 . Abbrecht PH, Rajagopal KR, Kyle RR. Expiratory muscle recruitment during inspiratory flow- resistive loading and exercise. Am Rev...Derderian SS, Rajagopal KR. Obesity , gender and sleep [editorial]. Chest 1988 May;93(5):900- 1 . Clinical Investigation. 412. Derderian SS, Rajagopal KR...Examination of the inhibitory and stimulatory effects of IFN- alpha, - beta , and -gamma on human B-cell proliferation induced by various B-cell mitogens. Clin
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1977-01-01
topography of the state of knowledge on the thermal expansion of nonmetallic solids. We believe there is also much food for reflec- West Lafayette...34 Lithium Silicates ......... 713 209 Magnesium Metasilicate MgSiO. .. ......... 715 210 Magnesium Orthosilicate Mg2 SiO . . . . . . . . . . . . 718 211...Antiferromagnetism of Praseodymium," Phys. Rev. Letters, 12(20), 553-5, 1964. 66. Goode, J.M., "Phase Transition Temperature of Polonium ,"J. Chem. Phys., 26(5), 1269
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2011-07-01
alternative to the REV and fracture network concepts, pp. 533-561, Rock Mechanics : Proceedings of the 28th U.S. Symposium, Tucson, Arizona, edited by I.W...spatially integrated measure of residual DNAPL volume in the flow without causing disturbances to the source zone domain [ Jin et al., 1995; Nelson and...step. 6 Hydrological inversion has been a major focus of groundwater hydrology during the last three decades [see Yeh, 1986; Sun , 1994 and
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ERIC Educational Resources Information Center
School Library Media Activities Monthly, 1996
1996-01-01
Describes a four-volume reference set for elementary and middle school students called "The Middle Ages: An Encyclopedia for Students" edited by William Chester Jordan. Provides a sample lesson which includes library media skills objectives, curriculum objectives, grade levels, resources, instructional roles, activity and procedures for…
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Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells
DOE Office of Scientific and Technical Information (OSTI.GOV)
Ramakrishnan, Sathiya N.; Lau, Patrick; Crowther, Lisa M.
2009-10-30
The nuclear hormone receptor, Rev-erb beta operates as a transcriptional silencer. We previously demonstrated that exogenous expression of Rev-erb{beta}{Delta}E in skeletal muscle cells increased Srebp-1c mRNA expression. We validated these in vitro observations by injection of an expression vector driving Rev-erb{beta}{Delta}E expression into mouse tibialis muscle that resulted in increased Srebp-1c mRNA expression. Paradoxically, Rev-erb{beta} siRNA expression in skeletal muscle cells repressed Srebp-1c expression, and indicated that Rev-erb{beta} expression was necessary for Srebp-1c expression. ChIP analysis demonstrated that Rev-erb{beta} was recruited to the Srebp-1c promoter. Moreover, Rev-erb{beta} trans-activated the Srebp-1c promoter, in contrast, Rev-erb{beta} efficiently repressed the Rev-erb{alpha} promoter, amore » previously characterized target gene. Finally, treatment with the Rev-erb agonist (hemin) (i) increased the trans-activation of the Srebp-1c promoter by Rev-erb{beta}; and (ii) increased Rev-erb{beta} and Srebp-1c mRNA expression. These data suggest that Rev-erb{beta} has the potential to activate gene expression, and is a positive regulator of Srebp-1c, a regulator of lipogenesis.« less
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Direct Density Functional Energy Minimization using an Tetrahedral Finite Element Grid
NASA Astrophysics Data System (ADS)
Vaught, A.; Schmidt, K. E.; Chizmeshya, A. V. G.
1998-03-01
We describe an O(N) (N proportional to volume) technique for solving electronic structure problems using the finite element method (FEM). A real--space tetrahedral grid is used as a basis to represent the electronic density, of a free or periodic system and Poisson's equation is solved as a boundary value problem. Nuclear cusps are treated using a local grid consisting of radial elements. These features facilitate the implementation of complicated energy functionals and permit a direct (constrained) energy minimization with respect to the density. We demonstrate the usefulness of the scheme by calculating the binding trends and polarizabilities of a number of atoms and molecules using a number of recently proposed non--local, orbital--free kinetic energy functionals^1,2. Scaling behavior, computational efficiency and the generalization to band--structure will also be discussed. indent 0 pt øbeylines øbeyspaces skip 0 pt ^1 P. Garcia-Gonzalez, J.E. Alvarellos and E. Chacon, Phys. Rev. B 54, 1897 (1996). ^2 A. J. Thakkar, Phys.Rev.B 46, 6920 (1992).
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Bogerd, H P; Wiegand, H L; Yang, J; Cullen, B R
2000-10-01
Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the approximately 25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.
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New mutations affecting induced mutagenesis in yeast.
Lawrence, C W; Krauss, B R; Christensen, R B
1985-01-01
Previously isolated mutations in baker's yeast, Saccharomyces cerevisiae, that impair induced mutagenesis were all identified with the aid of tests that either exclusively or predominantly detect base-pair substitutions. To avoid this bias, we have screened 11 366 potentially mutant clones for UV-induced reversion of the frameshift allele, his4-38, and have identified 10 mutants that give much reduced yields of revertants. Complementation and recombination tests show that 6 of these carry mutations at the previously known REV1, REV1 and REV3 loci, while the remaining 4 define 3 new genes, REV4 (2 mutations), REV5 and REV6. The rev4 mutations are readily suppressed in many genetic backgrounds and, like the rev5 mutation, impart only a limited deficiency for induced mutagenesis: it is likely, therefore that the REV4+ and REV5+ gene functions are only remotely concerned with this process. The rev6 mutants have a more general deficiency, however, as well as marked sensitivity to UV and an increased spontaneous mutation rate, properties that suggest the REV6 gene is directly involved in mutation induction. The REV5 gene is located about 1 cM proximal to CYC1 on chromosome X.
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Archetypal Analysis for Sparse Representation-Based Hyperspectral Sub-Pixel Quantification
NASA Astrophysics Data System (ADS)
Drees, L.; Roscher, R.
2017-05-01
This paper focuses on the quantification of land cover fractions in an urban area of Berlin, Germany, using simulated hyperspectral EnMAP data with a spatial resolution of 30m×30m. For this, sparse representation is applied, where each pixel with unknown surface characteristics is expressed by a weighted linear combination of elementary spectra with known land cover class. The elementary spectra are determined from image reference data using simplex volume maximization, which is a fast heuristic technique for archetypal analysis. In the experiments, the estimation of class fractions based on the archetypal spectral library is compared to the estimation obtained by a manually designed spectral library by means of reconstruction error, mean absolute error of the fraction estimates, sum of fractions and the number of used elementary spectra. We will show, that a collection of archetypes can be an adequate and efficient alternative to the spectral library with respect to mentioned criteria.
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Wang, Liyuan; Jiao, Hongchao; Zhao, Jingpeng; Wang, Xiaojuan; Sun, Shuhong; Lin, Hai
2017-01-01
Reticuloendotheliosis virus (REV), a gammaretrovirus in the Retroviridae family, causes an immunosuppressive, oncogenic, and runting–stunting syndrome in multiple avian hosts. Allicin, the main effective component of garlic, has a broad spectrum of pharmacological properties. The hypothesis that allicin could relieve REV-induced immune dysfunction was investigated in vivo and in vitro in the present study. The results showed that dietary allicin supplementation ameliorated REV-induced dysplasia and immune dysfunction in REV-infected chickens. Compared with the control groups, REV infection promoted the expression of inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-10, interferon (IFN)-γ, and tumor necrosis factor-α (TNF-α), whereas, allicin reversed these changes induced by REV infection. The decreased levels of IFN-α, IFN-β, and IL-2 were observed in REV-infected chickens, which were significantly improved by allicin. Allicin suppressed the REV-induced high expression of toll-like receptors (TLRs) as well as melanoma differentiation-associated gene 5 (MDA5) and the activation of mitogen-activated protein kinase (MAPK) and the nuclear factor kappa B p65. REV stimulated the phosphorylation of JNK, ERK, and p38, the downstream key signaling molecules of MAPK pathway, while allicin retarded the augmented phosphorylation level induced by REV infection. The decreased phosphorylation level of ERK was associated with REV replication, suggesting that ERK signaling is involved in REV replication, and allicin can alleviate the REV-induced immune dysfunction by inhibiting the activation of ERK. In addition, REV infection induced oxidative damage in thymus and spleen, whereas allicin treatment significantly decreased the oxidative stress induced by REV infection, suggesting that the antioxidant effect of allicin should be at least partially responsible for the harmful effect of REV infection. In conclusion, the findings suggest that allicin alleviates the inflammation and oxidative damage caused by REV infection and exerts the potential anti-REV effect by blocking the ERK/MAPK pathway. PMID:29312337
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Specificity in the immunosuppression induced by avian reticuloendotheliosis virus.
Walker, M H; Rup, B J; Rubin, A S; Bose, H R
1983-01-01
Several parameters of the cellular and humoral immune responses of chickens infected with reticuloendotheliosis virus (REV-T), an avian defective acute leukemia virus, or with its helper virus, reticuloendotheliosis-associated virus (REV-A), were evaluated. Spleen cells from chickens infected with REV-T (REV-A) or REV-A exhibited depressed mixed lymphocyte and mitogen responses in vitro. Allograft rejection was delayed by 6 to 14 days in birds infected with REV-A. The specific antitumor cell immune response was also studied by a 51Cr-release cytotoxicity assay. Lymphocytes from chickens infected with low numbers of the REV-T-transformed cells exhibited significant levels of cytolytic reactivity against the 51Cr-labeled REV-T tumor cells in vitro. The mitogen response of lymphocytes from these injected birds was similar to that of uninjected chickens. In contrast, lymphocytes from chickens injected with higher numbers of REV-T-transformed cells exhibited suppressed mitogen reactivity and failed to develop detectable levels of cytotoxic activity directed against the REV-T tumor cells. These results suggest that the general depression of cellular immune competence which occurs during REV-T (REV-A) infection could contribute to the development of this acute leukemia by inhibiting the proliferation of cytotoxic cells directed against the tumor cell antigens. The cytotoxic effect observed after the injection of chickens with non-immunosuppressive levels of REV-T-transformed cells appears to be specific for the REV-T tumor cell antigens since cells transformed by Marek's disease virus or avian erythroblastosis virus were not lysed. In marked contrast, birds whose cellular immune responses were suppressed by infection with REV-A were capable of producing a humoral immune response to viral antigens. Detectable levels of viral antibody, however, did not appear until 12 to 15 days after REV-A infection. Since REV-T (REV-A) induced an acute leukemia resulting in death within 7 to 14 days, it appears unlikely that the ability of chickens to make antiviral antibody influences the development of lethal reticuloendotheliosis. Images PMID:6187691
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Conversations in Excellence: Integrating Mission.
ERIC Educational Resources Information Center
Haney, Regina, Ed.; O'Keefe, Joseph, Ed.
In 1995 Catholic educators established Selected Programs for Improving Catholic Education (SPICE). The program is a form of action research that identifies, validates, and systematically diffuses elementary and secondary school programs that work. This handbook is the first volume in a series of annual National Catholic Educational Association…
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The Journal of the Society for Accelerative Learning and Teaching. Volume 14, 1989.
ERIC Educational Resources Information Center
Journal of the Society for Accelerative Learning and Teaching, 1989
1989-01-01
These four 1989 issues of the journal of the Society for Accelerated Learning and Teaching (SALT) include the following articles: "Retraining Cognitive Abilities: Combining Suggestopedia with Cognitive Behavior Modification"; "Students Discover the Joy of Learning Through Suggestopedia"; "Elementary School Achievement…
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Supercalculators and the Curriculum.
ERIC Educational Resources Information Center
Shumway, Richard
1990-01-01
Discussed are supercalculator capabilities and possible teaching implications. Included are six examples that use a supercalculator for topics that include volume, graphing, algebra, polynomials, matrices, and elementary calculus. A short review of the research on supercomputers in education and the impact they could have on the curriculum is…
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Investigations in Mathematics Education. Volume 16, Number 2.
ERIC Educational Resources Information Center
Investigations in Mathematics Education, 1983
1983-01-01
Abstracts of 11 mathematics education research studies are provided. Each abstract is accompanied by the abstractor's analysis of or comments about the study. Studies reported include: "The Importance of Spatial Visualization and Cognitive Development for Geometry Learning in Preservice Elementary Teachers"; "Classroom Ratio of High…
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ERIC Educational Resources Information Center
Dunn, Helen
Designed to provide Nevada's school population with information that will facilitate awareness and understanding of past and present Native Nevadan lifestyles and contributions, this generalized curriculum guide might constitute a social studies unit for upper elementary and/or junior high schools. Emphasis is on the cultural-historical influence…
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Pathfinder. Volume 9, Number 3, May/June 2011
2011-05-01
Pathfinder magazine .” Any reproduction of graphics, photographs and imagery is subject to the original copyright. 2 On My Mind 5 NGA in the News ›› F E A...team analyst stationed in Baghdad to search for and identify advertising billboards in Baghdad, a large and mundane task. To a CA commander, however...unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 On My Mind Putting the Power of GEOINT in the Warfighter’s Hands As a
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Acute Traumatic Coagulopathy: Whole Blood Thrombelastography Measures the Tip of the Iceberg
2015-01-01
with the thromboelastography analyser. Blood Coagul Fibrinolysis. 2009;20(6):436Y439. 14. Engstrom M , Schott U, Romner B , Reinstrup P. Acidosis impairs...PAGES 7 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b . ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...and 10KL) of 1- M 2-[morpholino]ethanesulfonic acidYbuffered saline (MBS) to a 300-KL volume sample in the TEG cup (Table 1). MBS was chosen for its
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2009-09-01
Sec. 2, while the latter ase—which implicitly includes the effects of image forces of efects in neighboring volume elements—may be more practical rom...versetzungen und eigenspannungen,” Arch . Ration. Mech. Anal., 4, pp. 273–334. 25 Lee, E. H., 1969, “Elastic-Plastic Deformation at Finite Strains,” ASME J...Rev., 73, pp. 373–382. 27 Kroner, E., and Seeger, A., 1959, “Nicht-Lineare Elastizitatstheorie der Verset- zungen und Eigenspannungen,” Arch . Ration
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1990-01-01
Wilson PD Jr: Fracture of the femoral component. Analysis of failure and long-term follow-up of rev-ision. Orthop Chin North Am 1988 Jul;19(3):637-47...DMED,DCI 88224857 Dysart SH, Savory CG, Callaghan JJ: Nonoperative treatment of a postoperative fracture around an uncemented porous-coated femoral...trochanter fractures of the hip without intertrochanteric extension: a case report. Milit Med 1988 Aug;153(8):421-3. DSURG 89015096 Lucente FE, Patow
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Naval War College Review. Volume 66, Number 4, Autumn 2013
2013-01-01
comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 2013 2. REPORT TYPE 3. DATES...unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Naval War College Press advIsory b oard adam bellow Jeffrey Kline gale a ...Mattox robert a . silano Marin strmecki dov s. Zakheim naval war college review edItorIal b oard donald Chisholm audrey Kurth Cronin Peter dombrowski
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1991-08-01
whereas control areas support more deciduous habitats (Blake et al. 1988). Differences in a variety of other habitat features also occur, but the deciduous...a heavy duty marine battery and was filtered through a 300 micrometer mesh filter and rolls of polyester in the common reservoir before flowing into...Ann. Rev. Systematics & Ecology, 5:309-323. Stout, R. Jean. 1981. How abiotic factors affect the distribution of two species of tropical predaceous
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2014-11-14
problem. Modification of the PLOS ONE | www.plosone.org 1 November 2014 | Volume 9 | Issue 11 | e112524 Report Documentation Page Form ApprovedOMB No. 0704... Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 FBA algorithm to incorporate additional biological information from gene expression profiles is...We set the maximization of biomass production as the objective of FBA and implemented it in two different forms : without flux minimization (or
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1983-06-01
of Christian’s force and capturing all of the Danish artillery and baggage. Christian fled to his stronghold of Holstein with the reumnts of his army...events that led to Yorktow began. Sources: C.) C. 13. 184 TIE NERICAN REV IONARY WAR Cow , 17 J _m,,,y 1781 Early in the morning of 17 Jumzy, Prigadier
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United States Air Force Summer Faculty Research Program 1989. Program Technical Report. Volume 3
1989-12-01
doppler broadened transitions by Holstein12 . We have used the functional form of Holstein and incorporated the 30 % increase 13 suggested by Phelps g...impact excitation of the 4 D level",J.Phys.B.,7,pp.2003-2020,1974. 12. T. Holstein ,"Imprisonment of Resonance Radiation in Gases. II",Physical Rev.,83...Backward Propagation Network FUNCTIONAL LINK NETWORKS Output Layer Devce ovice’lt one mNtdtq Camer Cowe . Oopng Corlc Functional MBE Input Characteristics
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Report of Operation Fitzwilliam. Volume 4 (REDACTED)
1952-10-01
notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not...19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98...aecretar,y Jir Force Personn§l Capt. G. E. D&~1 Lt. W. E. Petigo . S/Sgt. E. A~ Anderson Sgt. Pilao,n Sgt. : aaker Sgt, G. .A.d.ama Sgt. JobAaon
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Naval Law Review, Volume 54, 2007
2007-01-01
Aging Beauty: the Cox Commission Recommendations to Rejuvenate the Uniform Code of Military Justice, 2002 L. REV. M.S.U.-D.C.L. 111 While the accused...at 1037-38 (2003). See generally NATIONAL ACADEMY OF SCIENCES, BIOTECHNOLOGY RESEARCH IN AN AGE OF TERRORISM 46 (2004). 93 See “The Debate over BWC...EAA to expire in 2001 (50 U.S.C. app. § 2419) and, at the time of this writing, had not yet renewed the act or replaced it with a suitable substitute
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1998-02-01
diet of higher trophic level species, such as raptors. Ord’s Kangaroo Rat (Dipodomys ordii). The Ord’s kangaroo rat is chiefly a nocturnal mammal...sandy soils. The entrances of these burrow systems are plugged during the day to maintain humidity and coolness. The kangaroo rat can obtain...sufficient quantities of water from the metabolism of food in their diet, but will drink water when it is available. TSK 0003/SWERA/Rev Final Rpt/November
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ONRASIA Scientific Information Bulletin. Volume 17, Number 2, Apr-Jun 1992
1992-06-01
the Physics Division, Research 7. K Yagi, H . Onuki , S. Sugiyama, Department. Dr. Rehn received his andT. Yamazaki,BunkyoKenkyu 40(5) B.A. in physics at...Pittsburgh in 1962. Aftercomplet- 8. T. Saito, K Katori, M. Nishi, and ing his thesis research in nuclear H . Onuki , Rev. Sci. Instru. 60, 2303...quadrupole resonance studies of para (1989); T. Saito, K Katori, and H . Onuki , dichlorobenzene and related mate- Physica Scripta 41,783 (1990). rials, Dr. Rchn
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[Construction of Rev-erbβ gene knockout HEK293 cell line with CRISPR/Cas9 system].
Chen, Fang; Zhang, Weifeng; Zhao, Junli; Yang, Peiyan; Ma, Rui; Xia, Haibin
2016-11-01
Objective To prepare Rev-erbβ knockout HEK293 cells using clustered regularly interspaced short palindromic repeats/Cas 9 nuclease (CRISPR/Cas9) gene editing technology. Methods The knock-in or knockout of Rev-erbβ gene could be realized by single-guide RNA (sgRNA)-mediated Cas9 cutting of target DNA, and followed by DNA homologous recombination or non-homologous end joining-mediated DNA repair. Firstly, four sgRNAs were designed for Rev-erbβ gene. The sgRNA1 and sgRNA2 with the higher activity were respectively used to construct pCMV-hCas9-U6-Rev-erbβ sgRNA1 and pCMV-hCas9-U6-Rev-erbβ sgRNA2. Then, pCMV-hCas9-U6-Rev-erbβ sgRNA1, pCMV-hCas9-U6-Rev-erbβ sgRNA2 and pAd5-E1/hRev-erbβ donor plasmid vectors were co-transfected into HEK293 cells. Through drug screening, cloning and sequencing, the Rev-erbβ gene-knockout HEK293 (Rev-erbβ -/- ) cell lines were obtained with one chain integrated with exogenous gene fragment and the other chain for deletion mutants. Finally, the HEK293 (Rev-erbβ -/- ) cell lines (C3-6) was detected with real-time quantitative PCR and Western blotting. Results Expression of Rev-erbβ mRNA and protein was undetectable in HEK293 Rev-erbβ -/- cell line. Conclusion Using CRISPR/Cas9 technology, the HEK293 Rev-erbβ -/- cell line has been successfully constructed, which would provide an effective tool for the study on the function of Rev-erbβ.
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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Pariollaud, Marie; Gibbs, Julie E; Hopwood, Thomas W; Brown, Sheila; Begley, Nicola; Vonslow, Ryan; Poolman, Toryn; Guo, Baoqiang; Saer, Ben; Jones, D Heulyn; Tellam, James P; Bresciani, Stefano; Tomkinson, Nicholas Co; Wojno-Picon, Justyna; Cooper, Anthony Wj; Daniels, Dion A; Trump, Ryan P; Grant, Daniel; Zuercher, William; Willson, Timothy M; MacDonald, Andrew S; Bolognese, Brian; Podolin, Patricia L; Sanchez, Yolanda; Loudon, Andrew Si; Ray, David W
2018-06-01
Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity, involving both myeloid and bronchial epithelial cells in temporal gating and determining amplitude of response to inhaled endotoxin. Dual mutation of REV-ERBα and its paralog REV-ERBβ in bronchial epithelia further augmented inflammatory responses and chemokine activation, but also initiated a basal inflammatory state, revealing a critical homeostatic role for REV-ERB proteins in the suppression of the endogenous proinflammatory mechanism in unchallenged cells. However, REV-ERBα plays the dominant role, as deletion of REV-ERBβ alone had no impact on inflammatory responses. In turn, inflammatory challenges cause striking changes in stability and degradation of REV-ERBα protein, driven by SUMOylation and ubiquitination. We developed a novel selective oxazole-based inverse agonist of REV-ERB, which protects REV-ERBα protein from degradation, and used this to reveal how proinflammatory cytokines trigger rapid degradation of REV-ERBα in the elaboration of an inflammatory response. Thus, dynamic changes in stability of REV-ERBα protein couple the core clock to innate immunity.
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ERIC Educational Resources Information Center
Barton, Bill, Ed.; Irwin, Kathryn C., Ed.; Pfannkuch, Maxine, Ed.; Thomas, Michael O. J., Ed.
This document contains the proceedings of the 25th annual conference of the Mathematics Education Research Group of Australia (MERGA) held at the University of Auckland, New Zealand. The focus of this meeting is mathematics education in the South Pacific. Presentations are centered around the topic of numeracy in primary or elementary school.…
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FLES News, Volume 3, Numbers 1-3, 1989-1990.
ERIC Educational Resources Information Center
FLES News, 1990
1990-01-01
These three issues of the FLES News newsletter contain the following articles: "What I Learned in Second Grade: A French Teacher's Experience" (Pat Westphal); "Foreign Language Program Articulation: Building Bridges from Elementary to Secondary School" (Jo Anne Wilson; an ERIC Digest); "How Do Principals View Foreign…
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Love Is Like a Squished Banana
ERIC Educational Resources Information Center
Brown, Stephen
1976-01-01
An unemployed poet obtained a CETA public service job as a teacher's aide in Marin County, California, where he has guided elementary children's imaginative projects. His experiences are described. He has published a volume of the children's verse under the title "Love Is Like a Squished Banana." (AJ)
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Exploring Classroom Hydroponics. Growing Ideas.
ERIC Educational Resources Information Center
National Gardening Association, Burlington, VT.
Growing Ideas, the National Gardening Association's series for elementary, middle, and junior high school educators, helps teachers engage students in using plants and gardens as contexts for developing a deeper, richer understanding of the world around them. This volume's focus is on hydroponics. It presents basic hydroponics information along…
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ERIC Educational Resources Information Center
Dunn, Helen
As part of a continuing program designed to provide Nevada's school population with information that will facilitate greater awareness and understanding of both past and present Native Nevadan lifestyles and contributions, this generalized curriculum guide might constitute a social studies unit on early Indian culture for upper elementary and/or…
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Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome.
Singh, Bhupendra; Li, Xiurong; Owens, Kjerstin M; Vanniarajan, Ayyasamy; Liang, Ping; Singh, Keshav K
2015-01-01
To date, mitochondrial DNA polymerase γ (POLG) is the only polymerase known to be present in mammalian mitochondria. A dogma in the mitochondria field is that there is no other polymerase present in the mitochondria of mammalian cells. Here we demonstrate localization of REV3 DNA polymerase in the mammalian mitochondria. We demonstrate localization of REV3 in the mitochondria of mammalian tissue as well as cell lines. REV3 associates with POLG and mitochondrial DNA and protects the mitochondrial genome from DNA damage. Inactivation of Rev3 leads to reduced mitochondrial membrane potential, reduced OXPHOS activity, and increased glucose consumption. Conversely, inhibition of the OXPHOS increases expression of Rev3. Rev3 expression is increased in human primary breast tumors and breast cancer cell lines. Inactivation of Rev3 decreases cell migration and invasion, and localization of Rev3 in mitochondria increases survival and the invasive potential of cancer cells. Taken together, we demonstrate that REV3 functions in mammalian mitochondria and that mitochondrial REV3 is associated with the tumorigenic potential of cells.
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2003-01-01
183 3.34 5/rev fixed system hub normal force with 4/rev open loop trailing-edge flap input...184 3.35 5/rev fixed system hub normal force with 5/rev open loop trailing-edge flap input...185 3.36 5/rev fixed system hub normal force with 6/rev open loop trailing-edge flap
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A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.
Lin, Min-Hsuan; Sivakumaran, Haran; Jones, Alun; Li, Dongsheng; Harper, Callista; Wei, Ting; Jin, Hongping; Rustanti, Lina; Meunier, Frederic A; Spann, Kirsten; Harrich, David
2014-12-14
Previously we described a transdominant negative mutant of the HIV-1 Tat protein, termed Nullbasic, that downregulated the steady state levels of unspliced and singly spliced viral mRNA, an activity caused by inhibition of HIV-1 Rev activity. Nullbasic also altered the subcellular localizations of Rev and other cellular proteins, including CRM1, B23 and C23 in a Rev-dependent manner, suggesting that Nullbasic may disrupt Rev function and trafficking by intervening with an unidentified component of the Rev nucleocytoplasmic transport complex. To seek a possible mechanism that could explain how Nullbasic inhibits Rev activity, we used a proteomics approach to identify host cellular proteins that interact with Nullbasic. Forty-six Nullbasic-binding proteins were identified by mass spectrometry including the DEAD-box RNA helicase, DDX1. To determine the effect of DDX1 on Nullbasic-mediated Rev activity, we performed cell-based immunoprecipitation assays, Rev reporter assays and bio-layer interferometry (BLI) assays. Interaction between DDX1 and Nullbasic was observed by co-immunoprecipitation of Nullbasic with endogenous DDX1 from cell lysates. BLI assays showed a direct interaction between Nullbasic and DDX1. Nullbasic affected DDX1 subcellular distribution in a Rev-independent manner. Interestingly overexpression of DDX1 in cells not only restored Rev-dependent mRNA export and gene expression in a Rev reporter assay but also partly reversed Nullbasic-induced Rev subcellular mislocalization. Moreover, HIV-1 wild type Tat co-immunoprecipitated with DDX1 and overexpression of Tat could rescue the unspliced viral mRNA levels inhibited by Nullbasic in HIV-1 expressing cells. Nullbasic was used to further define the complex mechanisms involved in the Rev-dependent nuclear export of the 9 kb and 4 kb viral RNAs. All together, these data indicate that DDX1 can be sequestered by Nullbasic leading to destabilization of the Rev nucleocytoplasmic transport complex and decreased levels of Rev-dependent viral transcripts. The outcomes support a role for DDX1 in maintenance of a Rev nuclear complex that transports viral RRE-containing mRNA to the cytoplasm. To our knowledge Nullbasic is the first anti-HIV protein that specifically targets the cellular protein DDX1 to block Rev's activity. Furthermore, our research raises the possibility that wild type Tat may play a previously unrecognized but very important role in Rev function.
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Science Books, Volume 9 Number 1.
ERIC Educational Resources Information Center
Wolff, Kathryn, Ed.
This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in elementary and secondary schools and in the first two years of college. Included are selected advanced and professional books useful for reference by students and faculty members. A listing of detailed subject fields is…
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Science Books, Volume 10 Number 2.
ERIC Educational Resources Information Center
Wolff, Kathryn, Ed.
This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in elementary and secondary schools and in the first two years of college. Included are selected advanced and professional books useful to students and faculty members. A listing of detailed subject fields is provided including…
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Science Books: A Quarterly Review, Volume 5 Number 3.
ERIC Educational Resources Information Center
Deason, Hilary J.
This publication reviews tradebooks, textbooks, and reference works in the pure and applied sciences for students in the elementary schools, secondary schools, and in the first two years of college. Included are selected advanced and professional books useful for reference by students and faculty members. Evaluations and annotations of books…
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Science Books, Volume 10 Number 1.
ERIC Educational Resources Information Center
Wolff, Kathryn, Ed.
This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in elementary and secondary schools and in the first two year of college. Included are selected advanced and professional books useful for reference by students and faculty members. A listing of detailed subject fields is…
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Science Books: A Quarterly Review, Volume 8, Number 4.
ERIC Educational Resources Information Center
American Association for the Advancement of Science, Washington, DC.
This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in kindergartens, elementary schools, secondary schools, and in the first two years of college. Also included are selected advanced and professional books useful for reference by students and faculty members. Annotations are…
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Senda: Lectura 4 (Senda: Reader 4).
ERIC Educational Resources Information Center
Peniche Leger, Maria Elena, Ed.
This textbook, the fourth in a series of six, is designed to give the intermediate elementary school student continued practice in reading Spanish. It contains some 30 sections with passages of increasing degrees of difficulty. Colored illustrations are included. In this volume, Quetzalcoatl, god of the winds, conducts a group of children to…
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Paperless Braille Reading: A Preliminary Research Report.
ERIC Educational Resources Information Center
Bourgeois, M.; Ashcroft, S. C.
The study involving three blind elementary school, six blind high school, and four blind college students was designed to establish oral reading rates and oral reading error rates for Ss reading conventional braille volumes and brailled materials with the Digi-cassette, an electronic braille reading and writing machine. Data suggested several…
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"Celebrate Science" Has Formula for Hands-On Learning
ERIC Educational Resources Information Center
Brydolf, Carol
2012-01-01
Cost-effective, easily replicated program is a win-win situation for high schoolers who teach science and for their elementary students. The thank-you letter from Leslie, a grade-schooler in San Diego County's Ramona Unified School District, speaks volumes about the excitement generated by "Celebrate Science"--an innovative,…
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Science & Engineering Indicators 2016. National Science Board
ERIC Educational Resources Information Center
National Science Foundation, 2016
2016-01-01
"Science and Engineering Indicators" (SEI) is first and foremost a volume of record comprising high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI includes an overview and seven chapters that follow a generally consistent pattern. The chapter titles are as follows: (1) Elementary and…
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Education Policy Analysis Archives, 1997.
ERIC Educational Resources Information Center
Glass, Gene V., Ed.
1997-01-01
This electronic journal covers a variety of issues related to educational policy. The 22 articles (issues) of Volume 5 analyze aspects of policy in the United States and other countries for elementary, secondary, and higher education. Articles include: (1) "Markets and Myths: Autonomy in Public and Private schools" (Glass); (2) "Where Have All the…
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Upper Elementary Math Lessons: Case Studies of Real Teaching
ERIC Educational Resources Information Center
Graeber, Anna O.; Valli, Linda; Newton, Kristie Jones
2011-01-01
Engaging students in worthwhile learning requires more than a knowledge of underlying principles of good teaching. It demands considerable practice as well as images of what good teaching in particular situations and for particular purposes might look like. This volume provides these images. These cases were written from authentic, unrehearsed…
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English Leadership Quarterly, 1998-1999.
ERIC Educational Resources Information Center
Kiernan, Henry, Ed.
1999-01-01
This journal, a publication of the National Council of Teachers of English Conference on English Leadership, publishes articles on topics of interest to those in positions of leadership in departments (elementary, secondary, or college) where English is taught. Articles in Volume 21, Number 1, August 1998 are: "Problem-Based Leadership: A…
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Effective Elementary Social Studies.
ERIC Educational Resources Information Center
Hoge, John Douglas
This book advocates providing high-quality K-6 social studies instruction. The text provides practical information on how teachers can conduct high-quality social studies programs in their classrooms. The volume is divided into three parts. Part 1 offers an overview of the formal and informal social studies curriculum, its history, current status,…
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Studies in Mathematics, Volume X. Applied Mathematics in the High School.
ERIC Educational Resources Information Center
Schiffer, Max M.
This publication contains a sequence of lectures given to high school mathematics teachers by the author. Applications of mathematics emphasized are elementary algebra, geometry, and matrix algebra. Included are: (1) an introduction concerning teaching applications of mathematics; (2) Chapter 1: Mechanics for the High School Student; (3) Chapter…
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Psychological Intervention: Case Studies in School Psychological Services. Volume 2, 1978.
ERIC Educational Resources Information Center
Grimes, Jeff, Ed.
The 16 case studies illustrate the nature and scope of psychological intervention with emotionally disturbed and otherwise handicapped students. Included are papers with the following titles and authors: "Reducing Math Anxiety while Increasing Independent Work Habits in a Learning Disabled Elementary School Boy" (K. Hoogeveen); "Coping with…
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Evaluation of Title I ESEA Projects, 1976-77: Technical Reports. Report #77140.
ERIC Educational Resources Information Center
Philadelphia School District, PA. Office of Research and Evaluation.
This volume compiles technical reports of Title I Elementary and Secondary Education Act project evaluations conducted during the 1976-77 academic year in the school district of Philadelphia, Pennsylvania. The reports include rationale, expected outcomes, mode of operation, previous evaluative findings, current implementation, and attainment of…
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Grins and Groans of Publishing in Professional School Counseling
ERIC Educational Resources Information Center
Brott, Pamelia E.
2005-01-01
Professional School Counseling is the professional journal published by the American School Counselor Association (ASCA). The first volume of the journal was published in 1997 after the predecessor journals, The School Counselor and Elementary School Guidance Journal, merged. The School Counselor was in publication from the early 1950s and…
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IDRA Newsletter. Volume 43, No. 8
ERIC Educational Resources Information Center
Goodman, Christie L., Ed.
2016-01-01
Each edition of the IDRA Newsletter strives to provide many different perspectives on the issues in education topics discussed and to define its significance in the state and national dialogue. This issue focuses on Accountability and Civic Engagement and includes: (1) Will States Use ESSA [Elementary and Secondary Education Act] to Undermine…
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Investigations in Science Education. Volume 13, Number 3, 1987.
ERIC Educational Resources Information Center
Blosser, Patricia E., Ed.; Helgeson, Stanley L., Ed.
1987-01-01
Abstracts and abstractors' critiques of six research reports related to preservice teacher education and instruction are presented. Aspects addressed in the studies include: (1) teaching strategy analysis models in middle school science education courses; (2) concerns-based adoption model (CBAM): basis for an elementary science methods course; (3)…
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Harvard Education Letter. Volume 25, Number 6, November-December 2009
ERIC Educational Resources Information Center
Chauncey, Caroline T., Ed.
2009-01-01
"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) "Platooning" Instruction: Districts Weigh Pros and Cons of Departmentalizing Elementary Schools (Lucy Hood); (2) Behind the Classroom Door: A Rare Glimpse Indicates the…
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Project Basic Instructional Guide: Volume III, Citizenship.
ERIC Educational Resources Information Center
Maryland State Dept. of Education, Baltimore.
A series of elementary and secondary school learning activities which correlate to citizenship education goals of the Maryland State Board of Education are presented. The five goals are to understand individual and group responsibilities in a democracy, know the functions of law and support a system of justice, value individual, societal, and…
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Neural complexity: A graph theoretic interpretation
NASA Astrophysics Data System (ADS)
Barnett, L.; Buckley, C. L.; Bullock, S.
2011-04-01
One of the central challenges facing modern neuroscience is to explain the ability of the nervous system to coherently integrate information across distinct functional modules in the absence of a central executive. To this end, Tononi [Proc. Natl. Acad. Sci. USA.PNASA60027-842410.1073/pnas.91.11.5033 91, 5033 (1994)] proposed a measure of neural complexity that purports to capture this property based on mutual information between complementary subsets of a system. Neural complexity, so defined, is one of a family of information theoretic metrics developed to measure the balance between the segregation and integration of a system’s dynamics. One key question arising for such measures involves understanding how they are influenced by network topology. Sporns [Cereb. Cortex53OPAV1047-321110.1093/cercor/10.2.127 10, 127 (2000)] employed numerical models in order to determine the dependence of neural complexity on the topological features of a network. However, a complete picture has yet to be established. While De Lucia [Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.71.016114 71, 016114 (2005)] made the first attempts at an analytical account of this relationship, their work utilized a formulation of neural complexity that, we argue, did not reflect the intuitions of the original work. In this paper we start by describing weighted connection matrices formed by applying a random continuous weight distribution to binary adjacency matrices. This allows us to derive an approximation for neural complexity in terms of the moments of the weight distribution and elementary graph motifs. In particular, we explicitly establish a dependency of neural complexity on cyclic graph motifs.
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Kramers problem: Numerical Wiener-Hopf-like model characteristics
NASA Astrophysics Data System (ADS)
Ezin, A. N.; Samgin, A. L.
2010-11-01
Since the Kramers problem cannot be, in general, solved in terms of elementary functions, various numerical techniques or approximate methods must be employed. We present a study of characteristics for a particle in a damped well, which can be considered as a discretized version of the Melnikov [Phys. Rev. E 48, 3271 (1993)]10.1103/PhysRevE.48.3271 turnover theory. The main goal is to justify the direct computational scheme to the basic Wiener-Hopf model. In contrast to the Melnikov approach, which implements factorization through a Cauchy-theorem-based formulation, we employ the Wiener-Levy theorem to reduce the Kramers problem to a Wiener-Hopf sum equation written in terms of Toeplitz matrices. This latter can provide a stringent test for the reliability of analytic approximations for energy distribution functions occurring in the Kramers problems at arbitrary damping. For certain conditions, the simulated characteristics are compared well with those determined using the conventional Fourier-integral formulas, but sometimes may differ slightly depending on the value of a dissipation parameter. Another important feature is that, with our method, we can avoid some complications inherent to the Melnikov method. The calculational technique reported in the present paper may gain particular importance in situations where the energy losses of the particle to the bath are a complex-shaped function of the particle energy and analytic solutions of desired accuracy are not at hand. In order to appreciate more readily the significance and scope of the present numerical approach, we also discuss concrete aspects relating to the field of superionic conductors.
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The method of planes pressure tensor for a spherical subvolume
DOE Office of Scientific and Technical Information (OSTI.GOV)
Heyes, D. M., E-mail: d.heyes@imperial.ac.uk; Smith, E. R., E-mail: edward.smith05@imperial.ac.uk; Dini, D., E-mail: d.dini@imperial.ac.uk
2014-02-07
Various formulas for the local pressure tensor based on a spherical subvolume of radius, R, are considered. An extension of the Method of Planes (MOP) formula of Todd et al. [Phys. Rev. E 52, 1627 (1995)] for a spherical geometry is derived using the recently proposed Control Volume formulation [E. R. Smith, D. M. Heyes, D. Dini, and T. A. Zaki, Phys. Rev. E 85, 056705 (2012)]. The MOP formula for the purely radial component of the pressure tensor is shown to be mathematically identical to the Radial Irving-Kirkwood formula. Novel offdiagonal elements which are important for momentum conservation emergemore » naturally from this treatment. The local pressure tensor formulas for a plane are shown to be the large radius limits of those for spherical surfaces. The radial-dependence of the pressure tensor computed by Molecular Dynamics simulation is reported for virtual spheres in a model bulk liquid where the sphere is positioned randomly or whose center is also that of a molecule in the liquid. The probability distributions of angles relating to pairs of atoms which cross the surface of the sphere, and the center of the sphere, are presented as a function of R. The variance in the shear stress calculated from the spherical Volume Averaging method is shown to converge slowly to the limiting values with increasing radius, and to be a strong function of the number of molecules in the simulation cell.« less
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Pustovalova, Yulia; Magalhães, Mariana T. Q.; D’Souza, Sanjay; Rizzo, Alessandro A.; Korza, George; Walker, Graham C.; Korzhnev, Dmitry M.
2016-01-01
Translesion synthesis (TLS) is a mutagenic branch of cellular DNA damage tolerance that enables bypass replication over DNA lesions carried out by specialized low-fidelity DNA polymerases. The replicative bypass of most types of DNA damage is performed in a two-step process of Rev1/Polζ-dependent TLS. In the first step, a Y-family TLS enzyme, typically Polη, Polι or Polκ, inserts a nucleotide across DNA lesion. In the second step, a four-subunit B-family DNA polymerase Polζ (Rev3/Rev7/PolD2/PolD3 complex) extends the distorted DNA primer-template. The coordinated action of error-prone TLS enzymes is regulated through their interactions with the two scaffold proteins, the sliding clamp PCNA and the TLS polymerase Rev1. Rev1 interactions with all other TLS enzymes are mediated by its C-terminal domain (Rev1-CT), which can simultaneously bind the Rev7 subunit of Polζ and Rev1-interacting regions (RIRs) from Polη, Polι or Polκ. In this work, we identified a previously unknown RIR motif in the C-terminal part of PolD3 subunit of Polζ whose interaction with the Rev1-CT is among the tightest mediated by RIR motifs. Three-dimensional structure of the Rev1-CT/PolD3-RIR complex determined by NMR spectroscopy revealed a structural basis for the relatively high affinity of this interaction. The unexpected discovery of PolD3-RIR motif suggests a mechanism of 'inserter' to 'extender' DNA polymerase switch upon Rev1/Polζ-dependent TLS, in which the PolD3-RIR binding to the Rev1-CT (i) helps displace the 'inserter' Polη, Polι or Polκ from its complex with Rev1, and (ii) facilitates assembly of the four-subunit 'extender' Polζ through simultaneous interaction of Rev1-CT with Rev7 and PolD3 subunits. PMID:26982350
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Levosimendan Prevents Pressure-Overload-induced Right Ventricular Failure.
Hillgaard, Thomas Krarup; Andersen, Asger; Andersen, Stine; Vildbrad, Mads D; Ringgaard, Steffen; Nielsen, Jan M; Nielsen-Kudsk, Jens E
2016-04-01
We investigated if chronic levosimendan treatment can prevent and revert pressure-overload-induced right ventricular hypertrophy and failure in rats. Right ventricular hypertrophy and failure was induced in Wistar rats by pulmonary trunk banding (PTB). The PTB rats were treated with levosimendan (3 mg·kg·d) 3 days before surgery [n = 10, prevention (PREV)], 3 weeks after surgery [n = 10, reversal (REV)] or vehicle (n = 10, VEH). Sham-operated rats received vehicle (n = 16, SHAM). Right ventricular function was evaluated 7 weeks after surgery by echocardiography, magnetic resonance imaging, pressure-volume relations, gross anatomy, and histology. PTB induced right ventricular hypertrophy and compensated heart failure evident by reduced cardiac index (CI) without extra cardiac signs of heart failure. Levosimendan treatment prevented deterioration of right ventricular function measured by CI and right ventricular ejection fraction (RVEF) (CI: VEH vs. PREV 281 ± 17 vs. 362 ± 34 mL·min·kg, P ≤ 0.05, RVEF: VEH vs. PREV 57 ± 2% vs. 68 ± 3%, P ≤ 0.01) to values similar to SHAM (CI: 345 ± 21 mL·min·kg, RVEF: 71 ± 2%). RV contractility was improved in the REV group measured by preload recruitable stroke work (VEH vs. REV 39 ± 3 vs. 66 ± 10 mmHg P ≤ 0.05). Chronic treatment with levosimendan prevents the development of right ventricular failure and improves contractility in established pressure-overload-induced right ventricular failure.
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Global constraints on Z2 fluxes in two different anisotropic limits of a hypernonagon Kitaev model
NASA Astrophysics Data System (ADS)
Kato, Yasuyuki; Kamiya, Yoshitomo; Nasu, Joji; Motome, Yukitoshi
2018-05-01
The Kitaev model is an exactly-soluble quantum spin model, whose ground state provides a canonical example of a quantum spin liquid. Spin excitations from the ground state are fractionalized into emergent matter fermions and Z2 fluxes. The Z2 flux excitation is pointlike in two dimensions, while it comprises a closed loop in three dimensions because of the local constraint for each closed volume. In addition, the fluxes obey global constraints involving (semi)macroscopic number of fluxes. We here investigate such global constraints in the Kitaev model on a three-dimensional lattice composed of nine-site elementary loops, dubbed the hypernonagon lattice, whose ground state is a chiral spin liquid. We consider two different anisotropic limits of the hypernonagon Kitaev model where the low-energy effective models are described solely by the Z2 fluxes. We show that there are two kinds of global constraints in the model defined on a three-dimensional torus, namely, surface and volume constraints: the surface constraint is imposed on the even-odd parity of the total number of fluxes threading a two-dimensional slice of the system, while the volume constraint is for the even-odd parity of the number of the fluxes through specific plaquettes whose total number is proportional to the system volume. In the two anisotropic limits, therefore, the elementary excitation of Z2 fluxes occurs in a pair of closed loops so as to satisfy both two global constraints as well as the local constraints.
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Series of (2+1)-dimensional stable self-dual interacting conformal field theories
NASA Astrophysics Data System (ADS)
Cheng, Meng; Xu, Cenke
2016-12-01
Using the duality between seemingly different (2+1)-dimensional [(2 +1 )d ] conformal field theories (CFT) proposed recently [D. T. Son, Phys. Rev. X 5, 031027 (2015), 10.1103/PhysRevX.5.031027; M. A. Metlitski and A. Vishwanath, Phys. Rev. B 93, 245151 (2016), 10.1103/PhysRevB.93.245151; C. Wang and T. Senthil, Phys. Rev. X 6, 011034 (2015), 10.1103/PhysRevX.6.011034; C. Wang and T. Senthil, Phys. Rev. X 5, 041031 (2015), 10.1103/PhysRevX.5.041031; C. Wang and T. Senthil, Phys. Rev. B 93, 085110 (2016), 10.1103/PhysRevB.93.085110; C. Xu and Y.-Z. You, Phys. Rev. B 92, 220416 (2015), 10.1103/PhysRevB.92.220416; D. F. Mross et al., Phys. Rev. Lett. 117, 016802 (2016), 10.1103/PhysRevLett.117.016802; A. Karch and D. Tong, arXiv:1606.01893; N. Seiberg et al., arXiv:1606.01989; P.-S. Hsin and N. Seiberg, arXiv:1607.07457], we study a series of (2 +1 )d stable self-dual interacting CFTs. These CFTs can be realized (for instance) on the boundary of the 3 d bosonic topological insulator protected by U(1) and time-reversal symmetry (T ), and they remain stable as long as these symmetries are preserved. When realized as a boundary system, these CFTs can be driven into anomalous fractional quantum Hall states once T is broken. We demonstrate that the newly proposed dualities allow us to study these CFTs quantitatively through a controlled calculation, without relying on a large flavor number of matter fields. We also propose a numerical test for our results, which would provide strong evidence for the originally proposed duality between Dirac fermion and QED.
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Intelligent services for discovery of complex geospatial features from remote sensing imagery
NASA Astrophysics Data System (ADS)
Yue, Peng; Di, Liping; Wei, Yaxing; Han, Weiguo
2013-09-01
Remote sensing imagery has been commonly used by intelligence analysts to discover geospatial features, including complex ones. The overwhelming volume of routine image acquisition requires automated methods or systems for feature discovery instead of manual image interpretation. The methods of extraction of elementary ground features such as buildings and roads from remote sensing imagery have been studied extensively. The discovery of complex geospatial features, however, is still rather understudied. A complex feature, such as a Weapon of Mass Destruction (WMD) proliferation facility, is spatially composed of elementary features (e.g., buildings for hosting fuel concentration machines, cooling towers, transportation roads, and fences). Such spatial semantics, together with thematic semantics of feature types, can be used to discover complex geospatial features. This paper proposes a workflow-based approach for discovery of complex geospatial features that uses geospatial semantics and services. The elementary features extracted from imagery are archived in distributed Web Feature Services (WFSs) and discoverable from a catalogue service. Using spatial semantics among elementary features and thematic semantics among feature types, workflow-based service chains can be constructed to locate semantically-related complex features in imagery. The workflows are reusable and can provide on-demand discovery of complex features in a distributed environment.
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Interactions of Ultracold Impurity Particles with Bose-Einstein Condensates
2015-06-23
Lukin et al ., Phys. Rev. Lett. 87, 037901 (2001). [2] D. Jaksch et al ., Phys. Rev. Lett. 85, 2208 (2000). [3] L. Isenhower et al ., Phys. Rev. Lett...104, 010503 (2010). [4] T. Wilk et al ., Phys. Rev. Lett. 104, 010502 (2010). [5] I. Mourachko et al ., Phys. Rev. Lett. 80, 253 (1998). [6] W. R...Phys. 12, 103044 (2010). [12] R. M. W. van Bijnen et al ., J. Phys. B 44, 184008 (2011). [13] I. Lesanovsky, Phys. Rev. Lett. 106, 025301 (2011). [14] E
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Suppression of atherosclerosis by synthetic REV-ERB agonist
DOE Office of Scientific and Technical Information (OSTI.GOV)
Sitaula, Sadichha; Billon, Cyrielle; Kamenecka, Theodore M.
2015-05-08
The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks comparedmore » to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.« less
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Size distribution and growth rate of crystal nuclei near critical undercooling in small volumes
NASA Astrophysics Data System (ADS)
Kožíšek, Z.; Demo, P.
2017-11-01
Kinetic equations are numerically solved within standard nucleation model to determine the size distribution of nuclei in small volumes near critical undercooling. Critical undercooling, when first nuclei are detected within the system, depends on the droplet volume. The size distribution of nuclei reaches the stationary value after some time delay and decreases with nucleus size. Only a certain maximum size of nuclei is reached in small volumes near critical undercooling. As a model system, we selected recently studied nucleation in Ni droplet [J. Bokeloh et al., Phys. Rev. Let. 107 (2011) 145701] due to available experimental and simulation data. However, using these data for sample masses from 23 μg up to 63 mg (corresponding to experiments) leads to the size distribution of nuclei, when no critical nuclei in Ni droplet are formed (the number of critical nuclei < 1). If one takes into account the size dependence of the interfacial energy, the size distribution of nuclei increases to reasonable values. In lower volumes (V ≤ 10-9 m3) nucleus size reaches some maximum extreme size, which quickly increases with undercooling. Supercritical clusters continue their growth only if the number of critical nuclei is sufficiently high.
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Zan, Hong; White, Clayton A.; Thomas, Lisa M.; Mai, Thach; Li, Guideng; Xu, Zhenming; Zhang, Jinsong; Casali, Paolo
2012-01-01
SUMMARY By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR) plays a critical role in the maturation of the immune response. It is initiated by AID-mediated dC deamination, yielding dUs, and dU glycosylation by Ung in antibody switch (S) region DNA. Here we showed that the translesion DNA synthesis polymerase Rev1 directly interacted with Ung and targeted in an AID-dependent and Ung-independent fashion the S regions undergoing CSR. Rev1–/– Ung+/+ B cells reduced Ung recruitment to S regions, DNA-dU glycosylation and CSR. This together with an S region spectrum of mutations similar to that of Rev1+/+ Ung–/– B cells suggested that Rev1 operated in the same pathway as Ung, as emphasized by further decreased CSR in Rev1–/– Msh2–/– B cells. Rescue of CSR in Rev1–/– B cells by a catalytically inactive Rev1 mutant showed that the important role of Rev1 in CSR is mediated by Rev1 scaffold, not enzymatic function. PMID:23140944
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1980-02-01
formula for predictinq the number of errors during system testing. The equation he presents is B V/ ECRIT where B is the number of 19 ’R , errors...expected, V is the volume, and ECRIT is "the mean number of elementary discriminations between potential errors in programming" (p. 85). E CRIT can also...prediction of delivered bugs is: "V VX 2 B = V/ ECRIT -3- 13,824 2.3 McCabe’s Complexity Metric Thomas McCabe (1976) defined complexity in relation to
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Sensitivity of Double-Shell Ignition Capsules to Asymmetric Drive
NASA Astrophysics Data System (ADS)
Tregillis, I. L.; Magelssen, G. R.; Delamater, N. D.; Gunderson, M. A.; Hoffman, N. M.
2007-11-01
Double-shell (DS) targets [1] present an alternative approach to ignition via the cryogenic single-shell point design [2]. Although these targets present unique fabrication challenges, they embody many attractive features, including non-cryogenic fielding and low threshold temperatures (˜4 keV) for volume ignition [3-4]. We have used 2D radiation-hydrodynamic modeling to survey the behavior of DS targets under asymmetric temperature drive in rugby vacuum hohlraums. The yield is robust against deviations from symmetric illumination, varying smoothly as a function of the imposed P2 and P4 amplitudes. Ignition occurs even when 10% or more of the drive is contained in Legendre P2 or P4 components, with yield reductions on the order of 50% for the most extreme cases investigated here. [1] P. Amendt et al., Phys. of Plasmas 9, 2221 (2002) [2] D. A. Callahan et al., Phys. of Plasmas 13, 56307 (2005) [3] P. Amendt et al., Phys. Rev. Lett. 94, 65004 (2005) [4] W. S. Varnum et al., Phys. Rev. Lett. 84, 5153 (2000)
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1975-02-28
STATEMENT (ol Ih, »b.tfet »nftod in Block 30. II d/ ffa ,en( Irom Report) It. SUPPLEMENTARY NOTES 19. KEY WORDS (Conllnue on rev«., «ij» (/ nee» fry...given by 3-29 a^M—. K^^M^^M— ■ - - ■ ■■■■ ’■^-•—- P?B«BWWI^WW™’W"W,SIW!«W5F«^IIW»! BPP ^!^^ ..’ i •’ SSS-R-75-2556 Res(T0) L(T" - WC
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2008-09-01
Structure and the Western North Pacific Category 5 Typhoons. Part 1: Ocean Features and the Category 5 Typhoons’ Intensification 5a. CONTRACT NUMBER...intensification of category 5 cyclones. Based on 13 yr of satellite altimetry data, in situ &climatological upper-ocean thermal structure data, best-track...Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 3288 MONTHLY WEATHER REVIEW VOLUME 136 Upper-Ocean Thermal Structure and the Western North
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1975-11-01
was short- circuited by the surface current flowing in the skin-layer of a plasma channel. This current induced the magnetic field around the channel...subjects in the program of REB application to pulsed fusion. For this reason it was decided to carry out scaling experiments on multi- module radial...Sci. Instr. 41_, 1334 (1970). 7. M. Friedman and M. Ury, Rev. Sci. Instr. 43, 1659 (1972). 372 Figure 1. Circuit Diagram for the Long Pulse
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NASA Astrophysics Data System (ADS)
Krainov, V. P.; Roshchupkin, A. S.
2001-12-01
Dynamics of the inner and outer above-barrier ionization and of the Coulomb explosion are calculated for large hydrogen iodide clusters irradiated by superintense ultrashort laser pulses. We have found that the Coulomb forces predominate in the expansion of these clusters in comparison with the hydrodynamic forces. The energy distribution of the iodine multiple atomic ions in laser focal volume is derived. Results of our calculations are in a good agreement with the recent experimental data of Tisch et al. [Phys. Rev. A 60, 3076 (1999)].
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Air Force Civil Engineer, Volume 9, Number 2, Summer 2001
2001-01-01
c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 F R O M T H E T O P Are you ready for a Graduate Degree...Suite 1, Tyndall AFB, FL, 32403-5319, Telephone (850) 283-6242, DSN 523-6242, FAX (850) 283-6499, and e -mail: cemag@tyndall.af.mil. All submissions...ciently capture the most current publications and updates. Keeping training on track The COVER Train package includes an E -Tutor, which will be used by
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1993-05-20
1624 (1991); J. Liu, et al., Ph.D. Thesis , Univ. of Wisconsin, (1993) unpublished. 3 CONCLUSION [4] S.Y. Lee, et al., Phys. Rev. Lett. 67, 2767 (1991...34 Ph.D. Thesis , Stanford University, SLAC-387 (1991). ik L ~LL I~*~ 1, [5) H.Hne TasotadAclrto of Low Emit- ’ ... . .. •.. tance Electron Beams...the particles to fill the gap created by the [13] F. Zimmermann, Dipl. Thesis , DESY-HER, -[14] J.Irwin, Y. Yan, IEEE PAC 89, p. 1340 (1989
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Cullen, D.E.
1978-07-04
The code SIGMA1 Doppler broadens evaluated cross sections in the ENDF/B format. The code can be applied only to data that vary as a linear function of energy and cross section between tabulated points. This report describes the methods used in the code and serves as a user's guide to the code. 6 figures, 2 tables.
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Physics through the 1990s: Elementary-particle physics
NASA Astrophysics Data System (ADS)
The volume begins with a non-mathematical discussion of the motivation behind, and basic ideas of, elementary-particle physics theory and experiment. The progress over the past two decades with the quark model and unification of the electromagnetic and weak interactions is reviewed. Existing theoretical problems in the field, such as the origin of mass and the unification of the fundamental forces, are detailed, along with experimental programs to test the new theories. Accelerators, instrumentation, and detectors are described for both current and future facilities. Interactions with other areas of both theoretical and applied physics are presented. The sociology of the field is examined regarding the education of graduate students, the organization necessary in large-scale experiments, and the decision-making process involved in high-cost experiments. Finally, conclusions and recommendations for maintaining US excellence in theory and experiment are given. Appendices list both current and planned accelerators, and present statistical data on the US elementary-particle physics program. A glossary is included.
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Physics through the 1990s: elementary-particle physics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1986-01-01
The volume begins with a non-mathematical discussion of the motivation behind, and basic ideas of, elementary-particle physics theory and experiment. The progress over the past two decades with the quark model and unification of the electromagnetic and weak interactions is reviewed. Existing theoretical problems in the field, such as the origin of mass and the unification of the fundamental forces, are detailed, along with experimental programs to test the new theories. Accelerators, instrumentation, and detectors are described for both current and future facilities. Interactions with other areas of both theoretical and applied physics are presented. The sociology of the fieldmore » is examined regarding the education of graduate students, the organization necessary in large-scale experiments, and the decision-making process involved in high-cost experiments. Finally, conclusions and recommendations for maintaining US excellence in theory and experiment are given. Appendices list both current and planned accelerators, and present statistical data on the US elementary-particle physics program. A glossary is included.« less
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Tang, Min; Curtis, Sean; Yoon, Sung-Eui; Manocha, Dinesh
2009-01-01
We present an interactive algorithm for continuous collision detection between deformable models. We introduce multiple techniques to improve the culling efficiency and the overall performance of continuous collision detection. First, we present a novel formulation for continuous normal cones and use these normal cones to efficiently cull large regions of the mesh as part of self-collision tests. Second, we introduce the concept of "procedural representative triangles" to remove all redundant elementary tests between nonadjacent triangles. Finally, we exploit the mesh connectivity and introduce the concept of "orphan sets" to eliminate redundant elementary tests between adjacent triangle primitives. In practice, we can reduce the number of elementary tests by two orders of magnitude. These culling techniques have been combined with bounding volume hierarchies and can result in one order of magnitude performance improvement as compared to prior collision detection algorithms for deformable models. We highlight the performance of our algorithm on several benchmarks, including cloth simulations, N-body simulations, and breaking objects.
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Physics through the 1990s: Elementary-particle physics
NASA Technical Reports Server (NTRS)
1986-01-01
The volume begins with a non-mathematical discussion of the motivation behind, and basic ideas of, elementary-particle physics theory and experiment. The progress over the past two decades with the quark model and unification of the electromagnetic and weak interactions is reviewed. Existing theoretical problems in the field, such as the origin of mass and the unification of the fundamental forces, are detailed, along with experimental programs to test the new theories. Accelerators, instrumentation, and detectors are described for both current and future facilities. Interactions with other areas of both theoretical and applied physics are presented. The sociology of the field is examined regarding the education of graduate students, the organization necessary in large-scale experiments, and the decision-making process involved in high-cost experiments. Finally, conclusions and recommendations for maintaining US excellence in theory and experiment are given. Appendices list both current and planned accelerators, and present statistical data on the US elementary-particle physics program. A glossary is included.
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The 4M comPany: Make Mine Metric Marvels. Third Grade Student Booklet.
ERIC Educational Resources Information Center
Hawaii State Dept. of Education, Honolulu.
This student activity manual for elementary students is designed to teach several metric units. Included are activities related to length (meter), volume (liter), mass (grams), and temperature (celsius). Activities include a variety of drill sheets interspersed with other activities. Cartoons are used extensively to appeal to student interests.…
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The Beat of a Different Drummer: Essays on Educational Renewal in Honor of John I. Goodlad.
ERIC Educational Resources Information Center
Sirotnik, Kenneth A., Ed.; Soder, Roger, Ed.
This book contains essays by those who have been profoundly influenced by John Goodlad's research and scholarship on educational change and school improvement. The volume features 20 articles: "On Inquiry and Education," K. Sirotnik; "Invigorating Elementary Schooling: Savoring a Long-Term Partnership," R. Anderson;…
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EPIEgram: The Educational Consumers' Newsletter. Volume 17, Numbers 1-9, 1990-1991.
ERIC Educational Resources Information Center
EPIEgram: The Educational Consumers' Newsletter, 1991
1991-01-01
The nine issues of EPIEgram in this collection provide information about educational materials, educational technology, and elementary and secondary educational concerns. The following articles are included: (1) Designer Texts--Macmillan-McGraw To Offer Custom School Books; (2) Children's Lit is Alive and Well; (3) Swear Words, Satanism, and Sex;…
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Classroom Practices in ESL and Bilingual Education. Volume 1.
ERIC Educational Resources Information Center
Savaille-Troike, Muriel, Ed.
This publication is the first in a series planned to acquaint classroom teachers with successful methods and materials being used in TESOL and bilingual contexts. M. Saville-Troike illustrates several types of conflict which may occur in elementary classrooms when teachers do not understand the nature of the linguistic and cultural diversity of…
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Social Science in the Schools: A Search for Rationale.
ERIC Educational Resources Information Center
Morrissett, Irving; Stevens, W. William, Jr.
The focus of the volume is on reasons for selecting or not selecting any particular social science content, including history, for inclusion in the elementary and secondary social studies curriculum. Prominent authors from each of the social sciences--among them, Paul Ward, David Easton, and Ronald Lippitt--describe the nature of their disciplines…
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National Indian Education Association (NIEA) 2012 Legislative Agenda. Advocacy Briefing
ERIC Educational Resources Information Center
National Indian Education Association, 2012
2012-01-01
This volume contains advocacy briefing papers presented at the 15th Annual National Indian Education Association (NIEA) Legislative Summit held February 15-15, 2012 in Washington, DC. The following papers are included: (1) Become a Powerful Advocate; (2) NIEA Legislative Priority for 2012: Reauthorization of the Elementary and Secondary Education…
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Science Books, A Quarterly Review, Volume 7 Number 4.
ERIC Educational Resources Information Center
American Association for the Advancement of Science, Washington, DC.
"Science Books" is published quarterly to review trade books, textbooks, and reference works in the pure and applied sciences for students in the elementary school, secondary school, and first two years of college. It includes selected advanced and professional books useful for reference by students and faculty members. The approximately 200…
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Science Books, A Quarterly Review, Volume 7 Number 2.
ERIC Educational Resources Information Center
Science Books A Quarterly Review, 1971
1971-01-01
Science Books is published quarterly to review trade books, textbooks, and reference works in the pure and applied sciences for students in the elementary school, secondary school, and first two years of college. It includes selected advanced and professional books useful for reference by students and faculty members. The approximately 234 titles…
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Science Books, Volume 10 Number 4.
ERIC Educational Resources Information Center
Wolff, Kathryn, Ed.
This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in elementary and secondary schools and in the first two years of college. Included are selected advanced and professional books useful for reference by students and teachers. Each book is reviewed and annotated by a qualified…
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Science Books and Films, Volume 12 Number 2.
ERIC Educational Resources Information Center
Seltz-Petrash, Ann, Ed.
Reviewed are books and films in pure and applied sciences intended for students from elementary school to the second year of college, for the general reader/viewer, and for professional reference for teachers. Reviews indicate the level of difficulty from preschool to professional, an appraisal from highly recommended to not recommended, a signed…
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Science Books, A Quarterly Review, Volume 7 Number 3.
ERIC Educational Resources Information Center
American Association for the Advancement of Science, Washington, DC.
"Science Books" is published quarterly to review trade books, textbooks, and reference works in the pure and applied sciences for students in the elementary school, secondary school, and first two years of college. It includes selected advanced and professional books useful for reference by students and faculty members. The approximately 240…
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Science Books, A Quarterly Review, Volume 7 Number 1.
ERIC Educational Resources Information Center
Deason, Hilary J., Ed.
Approximately 200 trade books, and reference works in the pure and applied sciences for students in the elementary school, in secondary school and in the first two years of college, including selected advanced and professional books useful for reference by students and faculty members, are reviewed in this issue of the quarterly publication. The…
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Science Books, A Quarterly Review, Volume 8 Number 1.
ERIC Educational Resources Information Center
American Association for the Advancement of Science, Washington, DC.
This quarterly journal reviews trade books, textbooks, and reference works in the pure and applied sciences for students in the elementary schools, in secondary school and in the first two years of college. Included are selected advanced and professional books useful for reference by students and faculty members. Annotations are listed in order of…
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Science Books, Volume 9 Number 4.
ERIC Educational Resources Information Center
Wolff, Kathryn, Ed.
This quarterly publication of the American Association for the Advancement of Science contains reviews of trade books, textbooks, and reference works in the pure and applied sciences which are intended for students in the elementary and secondary schools and in the first two years of college. In addition, books on scientific topics intended for…
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The Promise of a Literacy Reform Effort in the Upper Elementary Grades
ERIC Educational Resources Information Center
Walpole, Sharon; Amendum, Steven; Pasquarella, Adrian; Strong, John Z.; McKenna, Michael C.
2017-01-01
We compared year-long gains in fluency and comprehension in grades 3-5 in 3 treatment and 4 comparison schools. Treatment schools implemented a comprehensive school reform (CSR) program called Bookworms. The program employed challenging text and emphasized high text volume, aggressive vocabulary and knowledge building, and contextualized strategy…
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Demonstration Aids for Aviation Education. [Volume II].
ERIC Educational Resources Information Center
Williams, Debbie; Hickson, Carol
This series consists of four packets containing simple, concrete activities for students in the upper elementary grades. The purpose of the series is to illustrate certain principles related to various concepts of aviation and space. Each packet forms a coherent program of instruction on a single topic: (1) non-powered flight; (2) aerospace and…
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ERIC Educational Resources Information Center
Buffie, Edward G.
The Block Program is one of five major options at Indiana University, Bloomington, for students preparing to become elementary teachers. The project emphasizes team approach to instruction; flexibility of program; carefully articulated work with respect to preparation in language arts, mathematics, science, and social studies; carefully…
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ERIC Educational Resources Information Center
Tryneski, John, Ed.
This volume updates certification requirements and other pertinent information for K-12 teachers, administrators, librarians, counselors, and other school personnel. The publication lists: certification requirements for each state in the United States and the District of Columbia; recommendations of regional and national associations (Middle…
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Federal Programs Supporting Educational Change, Vol. 2: Factors Affecting Change Agent Projects.
ERIC Educational Resources Information Center
Berman, Paul; Pauly, Edward W.
This second volume in the change-agent series reports the interim results of an exploratory statistical analysis of a survey of a nationwide sample of 293 change-agent projects funded by four federal demonstration programs--Elementary Secondary Education Act (ESEA) Title III, Innovative Projects; ESEA Title VII, Bilingual Projects; Vocational…
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ERIC Educational Resources Information Center
City Univ. of New York, Flushing, NY. Queens Coll.
This Teacher Education and Mathematics (TEAM) content module focuses on metric measurement. Topics addressed include decimal structure and prefixes, precision in measurement, reference measures, United States customary and metric systems, volume, area, and conversion. The module consists of: (1) an instructor's text; (2) an instructor's guide and…
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The 4M compaNy: Make Mine Metric Mystery. Fifth Grade Student Booklet.
ERIC Educational Resources Information Center
Hawaii State Dept. of Education, Honolulu.
This student activity manual for elementary students is designed to teach several concepts related to the metric system and measurement. Included are activities related to length, area, volume, conversion of metric units, and computation skills with decimals (addition, subtraction, and division). Cartoons are used extensively to appeal to student…
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A Subject Classification of Math Lab Activities from School Science and Mathematics 1974-1980.
ERIC Educational Resources Information Center
Grinstein, Louise S.
1982-01-01
Presented here is an index which indicates the title and location of each activity by volume and page numbers. The majority of items relate to arithmetic, elementary algebra, and plane geometry, but material also covers such topics as statistics, probability, trigonometry set theory, topology, and modern algebra. (MP)
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The Journal of Suggestive-Accelerative Learning and Teaching, Volume 3, Number 4, Winter 1978.
ERIC Educational Resources Information Center
Schuster, Donald H., Ed.
Contents of this issue are as follows: "Audio-Visual Material Development for Suggestopedic Classes" by Charles Loch (16 pages), "Suggestopedia Applied to Elementary Reading Instruction" by Allyn Prichard and Jean Taylor (5 pages), "Suggestology or Hypnosis--It's All in the Label" by Harry E. Stanton (5 pages),…
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ERIC Educational Resources Information Center
Hoge, John D., Ed.; Blum, Ann, Ed.
The lessons in this volume, written by experienced Georgia teachers with backgrounds in law-related education, were designed for teachers new to this area of the social studies curriculum. The lessons, which are organized by grade level, include the following information: author, time required, concepts/vocabulary, main ideas, instructional…
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ERIC Educational Resources Information Center
Jarvis, Gilbert A., Ed.
This volume on foreign language teaching and learning concerns the following topics: lifelong learning, small-group learning, the minicourse, student attitudes toward foreign languages, problems in secondary schools, humanistic education, curricula in uncommonly taught languages, foreign languages in elementary and adolescent-centered education,…
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Teaching Handicapped Students English: A Resource Handbook for K-12 Teachers.
ERIC Educational Resources Information Center
Price, Jane W., Ed.
One of five volumes devoted to teaching content subjects to the handicapped, the book addresses ways in which elementary and secondary regular class teachers have successfully worked with mainstreamed students in English. The following titles and authors are included: "Chris Learns to Read" (E. Roake); "Working Together" (B. Bodner-Johnson);…
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Revista de Investigacion Educativa, 2000 (Journal of Educational Research, 2000).
ERIC Educational Resources Information Center
Revista de Investigacion Educativa, 2000
2000-01-01
Articles in this volume focus on the following: teacher evaluation and quality management in education; steps toward a comprehensive and systematic staff evaluation; opinions of university students on teaching methods at science faculties; design of a scale to assess the ability to jump for the use in elementary school physical education; effects…
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Guidelines for the CSMP K-6 Curriculum in Graph Theory.
ERIC Educational Resources Information Center
Deskins, W. E.; And Others
This volume is designed for teachers preparing to teach upper elementary students using the Comprehensive School Mathematics Program (CSMP) curriculum. It begins with a discussion of the importance of graph theory in mathematics and science. A mathematical development of graph-theoretic concepts and theorems is presented, followed by a set of…
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ERIC Educational Resources Information Center
Christensen, Gayle S.
2007-01-01
The reauthorization of the "Elementary and Secondary Education Act" ("ESEA") as amended by the "No Child Left Behind Act of 2001" ("NCLB") relied on two notable policy instruments to improve education: accountability and flexibility. "NCLB" complements accountability with several new flexibility…
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Research in Secondary Schools. Advances in Learning and Behavioral Disabilities. Volume 17
ERIC Educational Resources Information Center
Scruggs, Thomas E., Ed.; Mastropieri, Margo A., Ed.
2004-01-01
Secondary education of students with learning and behavioral disabilities is an issue of great importance. Unlike elementary schools, secondary schools require substantially more independent functioning, assume the effective use of student planning and study skills, and often lack the classes in basic skills needed by some learners. Further, new…
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Metric Education in Mathematics Methods Classes.
ERIC Educational Resources Information Center
Trent, John H.
A pre-test on knowledge of the metric system was administered to elementary mathematics methods classes at the University of Nevada at the beginning of the 1975 Spring Semester. A one-hour lesson was prepared and taught regarding metric length, weight, volume, and temperature. At the end of the semester the original test was given as the…
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Straight A's: Public Education Policy and Progress. Volume 10, Number 10
ERIC Educational Resources Information Center
Alliance for Excellent Education, 2010
2010-01-01
"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) ESEA [Elementary and Secondary Education Act] Reauthorization Shifts to Middle and High Schools: Senate HELP [Health,…
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Marin County Teacher Learning Cooperative: Phase II, Volume 1.
ERIC Educational Resources Information Center
Balzan, Robert A.
This report describes the second phase of a teacher learning cooperative project designed to coordinate the economic, physical, and human resources of a number of small elementary school districts in California and the Marin County Superintendent of Schools Office. Whereas the first phase dealt with the formation and implementation of the…
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Marin County Teacher Learning Cooperative: Phase II, Volume 2.
ERIC Educational Resources Information Center
Balzan, Robert A.
This report describes the second phase of a teacher learning cooperative project designed to coordinate the economic, physical, and human resources of a number of small elementary school districts in California and the Marin County Superintendent of Schools Office. Whereas the first phase dealt with the formation and implementation of the…
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PK-3: What Does It Mean for Instruction? Social Policy Report. Volume 30, Number 2
ERIC Educational Resources Information Center
Stipek, Deborah; Franke, Megan; Clements, Doug; Farran, Dale; Coburn, Cynthia
2017-01-01
"PK--3" has become a rallying cry among many developmental scientists and educators. A central component of this movement is alignment between preschool and the early elementary grades. Many districts have made policy changes designed to promote continuity in children's educational experiences as they progress from preschool through…
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Resources for Teaching Linear Algebra. MAA Notes Volume 42.
ERIC Educational Resources Information Center
Carlson, David, Ed.; And Others
This book takes the position that the teaching of elementary linear algebra can be made more effective by emphasizing applications, exposition, and pedagogy. It includes the recommendations of the Linear Algebra Curriculum Study Group with their core syllabus for the first course, and the thoughts of mathematics faculty who have taught linear…
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Proposing and Testing a Model to Explain Traits of Algebra Preparedness
ERIC Educational Resources Information Center
Venenciano, Linda; Heck, Ronald
2016-01-01
Early experiences with theoretical thinking and generalization in measurement are hypothesized to develop constructs we name here as logical reasoning and preparedness for algebra. Based on work of V. V. Davydov (1975), the Measure Up (MU) elementary grades experimental mathematics curriculum uses quantities of area, length, volume, and mass to…
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Current Subcounty Allocation Practices: Volume I of the Title I, ESEA, Subcounty Allocation Study.
ERIC Educational Resources Information Center
Paller, Alan T.; Gutmann, Babette
In this report, subcounty allocation of Title I of the Elementary and Secondary Education Act (ESEA) funds is described in terms of direct allocation, use of the statutory formula emphasizing census data, United States Office of Education (USOE) regulations, participating states, geographic and administrative overlaps, hold harmless adjustments…
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Economics in History and the Social Sciences.
ERIC Educational Resources Information Center
Joint Council on Economic Education, New York, NY.
Papers presented by social scientists at a 1974 Joint Council seminar designed to assist authors and publishers in improving existing materials or developing new texts in social studies are reproduced in this volume. The seven papers focus on how to integrate economics into elementary and secondary social studies and history courses. The first…
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Harvard Education Letter. Volume 23, Number 2, March-April 2007
ERIC Educational Resources Information Center
Chauncey, Caroline, Ed.
2007-01-01
"Harvard Education Letter" is published bimonthly at the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) More Than "Making Nice": Getting Teachers to (Truly) Collaborate (Laura Pappano); (2) "Doing the Critical Things First": An Aligned Approach to PreK and Early Elementary Math;…
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Harvard Education Letter. Volume 24, Number 6, November-December 2008
ERIC Educational Resources Information Center
Chauncey, Caroline, Ed.
2008-01-01
"Harvard Education Letter" is published bimonthly by the Harvard Graduate School of Education. This issue of "Harvard Education Letter" contains the following articles: (1) When Worlds Collide: Universal PreK Brings New Challenges for Public Elementary Schools (David McKay Wilson); (2) Answers and Questions: Schools Survey Their Students--and…
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Science is Elementary, A Science Teaching Resource Publication, 1992-1993.
ERIC Educational Resources Information Center
Science is Elementary, 1993
1993-01-01
These resource magazines for K-6 educators are published to promote the teaching of science, mathematics, and technology through participatory, inquiry-based methods. Each issue provides resources and hands-on activities for educators that focus on one theme. Issues in volume 5 cover the themes of geology, math and science integration, tropical…
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NASA Astrophysics Data System (ADS)
Russ, Maximilian; Burkard, Guido
2017-10-01
The goal of this article is to review the progress of three-electron spin qubits from their inception to the state of the art. We direct the main focus towards the exchange-only qubit (Bacon et al 2000 Phys. Rev. Lett. 85 1758-61, DiVincenzo et al 2000 Nature 408 339) and its derived versions, e.g. the resonant exchange (RX) qubit, but we also discuss other qubit implementations using three electron spins. For each three-spin qubit we describe the qubit model, the envisioned physical realization, the implementations of single-qubit operations, as well as the read-out and initialization schemes. Two-qubit gates and decoherence properties are discussed for the RX qubit and the exchange-only qubit, thereby completing the list of requirements for quantum computation for a viable candidate qubit implementation. We start by describing the full system of three electrons in a triple quantum dot, then discuss the charge-stability diagram, restricting ourselves to the relevant subsystem, introduce the qubit states, and discuss important transitions to other charge states (Russ et al 2016 Phys. Rev. B 94 165411). Introducing the various qubit implementations, we begin with the exchange-only qubit (DiVincenzo et al 2000 Nature 408 339, Laird et al 2010 Phys. Rev. B 82 075403), followed by the RX qubit (Medford et al 2013 Phys. Rev. Lett. 111 050501, Taylor et al 2013 Phys. Rev. Lett. 111 050502), the spin-charge qubit (Kyriakidis and Burkard 2007 Phys. Rev. B 75 115324), and the hybrid qubit (Shi et al 2012 Phys. Rev. Lett. 108 140503, Koh et al 2012 Phys. Rev. Lett. 109 250503, Cao et al 2016 Phys. Rev. Lett. 116 086801, Thorgrimsson et al 2016 arXiv:1611.04945). The main focus will be on the exchange-only qubit and its modification, the RX qubit, whose single-qubit operations are realized by driving the qubit at its resonant frequency in the microwave range similar to electron spin resonance. Two different types of two-qubit operations are presented for the exchange-only qubits which can be divided into short-ranged and long-ranged interactions. Both of these interaction types are expected to be necessary in a large-scale quantum computer. The short-ranged interactions use the exchange coupling by placing qubits next to each other and applying exchange-pulses (DiVincenzo et al 2000 Nature 408 339, Fong and Wandzura 2011 Quantum Inf. Comput. 11 1003, Setiawan et al 2014 Phys. Rev. B 89 085314, Zeuch et al 2014 Phys. Rev. B 90 045306, Doherty and Wardrop 2013 Phys. Rev. Lett. 111 050503, Shim and Tahan 2016 Phys. Rev. B 93 121410), while the long-ranged interactions use the photons of a superconducting microwave cavity as a mediator in order to couple two qubits over long distances (Russ and Burkard 2015 Phys. Rev. B 92 205412, Srinivasa et al 2016 Phys. Rev. B 94 205421). The nature of the three-electron qubit states each having the same total spin and total spin in z-direction (same Zeeman energy) provides a natural protection against several sources of noise (DiVincenzo et al 2000 Nature 408 339, Taylor et al 2013 Phys. Rev. Lett. 111 050502, Kempe et al 2001 Phys. Rev. A 63 042307, Russ and Burkard 2015 Phys. Rev. B 91 235411). The price to pay for this advantage is an increase in gate complexity. We also take into account the decoherence of the qubit through the influence of magnetic noise (Ladd 2012 Phys. Rev. B 86 125408, Mehl and DiVincenzo 2013 Phys. Rev. B 87 195309, Hung et al 2014 Phys. Rev. B 90 045308), in particular dephasing due to the presence of nuclear spins, as well as dephasing due to charge noise (Medford et al 2013 Phys. Rev. Lett. 111 050501, Taylor et al 2013 Phys. Rev. Lett. 111 050502, Shim and Tahan 2016 Phys. Rev. B 93 121410, Russ and Burkard 2015 Phys. Rev. B 91 235411, Fei et al 2015 Phys. Rev. B 91 205434), fluctuations of the energy levels on each dot due to noisy gate voltages or the environment. Several techniques are discussed which partly decouple the qubit from magnetic noise (Setiawan et al 2014 Phys. Rev. B 89 085314, West and Fong 2012 New J. Phys. 14 083002, Rohling and Burkard 2016 Phys. Rev. B 93 205434) while for charge noise it is shown that it is favorable to operate the qubit on the so-called ‘(double) sweet spots’ (Taylor et al 2013 Phys. Rev. Lett. 111 050502, Shim and Tahan 2016 Phys. Rev. B 93 121410, Russ and Burkard 2015 Phys. Rev. B 91 235411, Fei et al 2015 Phys. Rev. B 91 205434, Malinowski et al 2017 arXiv: 1704.01298), which are least susceptible to noise, thus providing a longer lifetime of the qubit.
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The Nuclear Receptor Rev-erbα Controls Circadian Thermogenic Plasticity
Gerhart-Hines, Zachary; Everett, Logan J.; Loro, Emanuele; Briggs, Erika R.; Bugge, Anne; Hou, Catherine; Ferrara, Christine; Seale, Patrick; Pryma, Daniel A.; Khurana, Tejvir S.; Lazar, Mitchell A.
2013-01-01
Circadian oscillation of body temperature is a basic, evolutionary-conserved feature of mammalian biology1. Additionally, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure2. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα, a powerful transcriptional repressor, links circadian and thermogenic networks through the regulation of brown adipose tissue (BAT) function. Mice exposed to cold fare dramatically better at 5 AM (Zeitgeber time 22) when Rev-erbα is barely expressed than at 5 PM (ZT10) when Rev-erbα is abundant. Deletion of Rev-erbα markedly improves cold tolerance at 5 PM, indicating that overcoming Rev-erbα-dependent repression is a fundamental feature of the thermogenic response to cold. Physiological induction of uncoupling protein 1 (UCP1) by cold temperatures is preceded by rapid down-regulation of Rev-erbα in BAT. Rev-erbα represses UCP1 in a brown adipose cell-autonomous manner and BAT UCP1 levels are high in Rev-erbα-null mice even at thermoneutrality. Genetic loss of Rev-erbα also abolishes normal rhythms of body temperature and BAT activity. Thus, Rev-erbα acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands. PMID:24162845
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Chekmarev, Sergei F
2013-03-01
The transition from laminar to turbulent fluid motion occurring at large Reynolds numbers is generally associated with the instability of the laminar flow. On the other hand, since the turbulent flow characteristically appears in the form of spatially localized structures (e.g., eddies) filling the flow field, a tendency to occupy such a structured state of the flow cannot be ruled out as a driving force for turbulent transition. To examine this possibility, we propose a simple analytical model that treats the flow as a collection of localized spatial structures, each of which consists of elementary cells in which the behavior of the particles (atoms or molecules) is uncorrelated. This allows us to introduce the Reynolds number, associating it with the ratio between the total phase volume for the system and that for the elementary cell. Using the principle of maximum entropy to calculate the most probable size distribution of the localized structures, we show that as the Reynolds number increases, the elementary cells group into the localized structures, which successfully explains turbulent transition and some other general properties of turbulent flows. An important feature of the present model is that a bridge between the spatial-statistical description of the flow and hydrodynamic equations is established. We show that the basic assumptions underlying the model, i.e., that the particles are indistinguishable and elementary volumes of phase space exist in which the state of the particles is uncertain, are involved in the derivation of the Navier-Stokes equation. Taking into account that the model captures essential features of turbulent flows, this suggests that the driving force for the turbulent transition is basically the same as in the present model, i.e., the tendency of the system to occupy a statistically dominant state plays a key role. The instability of the flow at high Reynolds numbers can then be a mechanism to initiate structural rearrangement of the flow to find this state.
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Link-Prediction Enhanced Consensus Clustering for Complex Networks (Open Access)
2016-05-20
92:022816. Available from: http://link.aps.org/doi/10.1103/PhysRevE.92.022816. doi: 10. 1103 /PhysRevE.92.022816 16. Aldecoa R, Marín I. Exploring the...from: http://link.aps.org/doi/10.1103/PhysRevE.80.056117. doi: 10. 1103 /PhysRevE.80.056117 18. Dahlin J, Svenson P. Ensemble approaches for improving...046110. Available from: http://link.aps.org/doi/10.1103/PhysRevE.81.046110. doi: 10. 1103 /PhysRevE.81.046110 28. Gfeller D, Chappelier JC, De Los Rios P
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Huang, Feng; Zhang, Junsong; Zhang, Yijun
Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-boxmore » of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. - Highlights: • MOV10 can function as a co-factor of HIV-1 Rev. • MOV10 facilitates Rev/RRE-dependent transport of viral mRNAs. • MOV10 interacts with Rev in an RNA-independent manner. • The DEAG-box of MOV10 is required for the enhancement of Rev/RRE-dependent export.« less
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Electrokinetic coupling in unsaturated porous media.
Revil, A; Linde, N; Cerepi, A; Jougnot, D; Matthäi, S; Finsterle, S
2007-09-01
We consider a charged porous material that is saturated by two fluid phases that are immiscible and continuous on the scale of a representative elementary volume. The wetting phase for the grains is water and the nonwetting phase is assumed to be an electrically insulating viscous fluid. We use a volume-averaging approach to derive the linear constitutive equations for the electrical current density as well as the seepage velocities of the wetting and nonwetting phases on the scale of a representative elementary volume. These macroscopic constitutive equations are obtained by volume-averaging Ampère's law together with the Nernst-Planck equation and the Stokes equations. The material properties entering the macroscopic constitutive equations are explicitly described as functions of the saturation of the water phase, the electrical formation factor, and parameters that describe the capillary pressure function, the relative permeability functions, and the variation of electrical conductivity with saturation. New equations are derived for the streaming potential and electro-osmosis coupling coefficients. A primary drainage and imbibition experiment is simulated numerically to demonstrate that the relative streaming potential coupling coefficient depends not only on the water saturation, but also on the material properties of the sample, as well as the saturation history. We also compare the predicted streaming potential coupling coefficients with experimental data from four dolomite core samples. Measurements on these samples include electrical conductivity, capillary pressure, the streaming potential coupling coefficient at various levels of saturation, and the permeability at saturation of the rock samples. We found very good agreement between these experimental data and the model predictions.
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Sail, Vibhavari; Rizzo, Alessandro A; Chatterjee, Nimrat; Dash, Radha C; Ozen, Zuleyha; Walker, Graham C; Korzhnev, Dmitry M; Hadden, M Kyle
2017-07-21
Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anticancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. The TLS DNA polymerase Rev1 serves as an integral scaffolding protein that mediates the assembly of the active multiprotein TLS complexes. Protein-protein interactions (PPIs) between the C-terminal domain of Rev1 (Rev1-CT) and the Rev1-interacting region (RIR) of other TLS DNA polymerases play an essential role in regulating TLS activity. To probe whether disrupting the Rev1-CT/RIR PPI is a valid approach for developing a new class of targeted anticancer agents, we designed a fluorescence polarization-based assay that was utilized in a pilot screen for small molecule inhibitors of this PPI. Two small molecule scaffolds that disrupt this interaction were identified, and secondary validation assays confirmed that compound 5 binds to Rev1-CT at the RIR interface. Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.
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Pozhidaeva, Alexandra; Pustovalova, Yulia; D'Souza, Sanjay; Bezsonova, Irina; Walker, Graham C.; Korzhnev, Dmitry M.
2013-01-01
Rev1 is a translesion synthesis (TLS) DNA polymerase essential for DNA damage tolerance in eukaryotes. In the process of TLS stalled high-fidelity replicative DNA polymerases are temporarily replaced by specialized TLS enzymes that can bypass sites of DNA damage (lesions), thus allowing replication to continue or postreplicational gaps to be filled. Despite its limited catalytic activity, human Rev1 plays a key role in TLS by serving as a scaffold that provides an access of Y-family TLS polymerases polη, ι, and κ to their cognate DNA lesions and facilitates their subsequent exchange to polζ that extends the distorted DNA primer-template. Rev1 interaction with the other major human TLS polymerases, polη, ι, κ and the regulatory subunit Rev7 of polζ, is mediated by Rev1 C-terminal domain (Rev1-CT). We used NMR spectroscopy to determine the spatial structure of the Rev1-CT domain (residues 1157-1251) and its complex with Rev1 interacting region (RIR) from polη (residues 524-539). The domain forms a four-helix bundle with a well-structured N-terminal β-hairpin docking against helices 1 and 2, creating a binding pocket for the two conserved Phe residues of the RIR motif that upon binding folds into an α-helix. NMR spin-relaxation and NMR relaxation dispersion measurements suggest that free Rev1-CT and Rev1-CT/polη-RIR complex exhibit μs-ms conformational dynamics encompassing the RIR binding site, which might facilitate selection of the molecular configuration optimal for binding. These results offer new insights into the control of TLS in human cells by providing a structural basis for understanding the recognition of the Rev1-CT by Y-family DNA polymerases. PMID:22691049
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Song, Chao; Tan, Peng; Zhang, Zheng; Wu, Wei; Dong, Yonghui; Zhao, Liming; Liu, Huiyong; Guan, Hanfeng; Li, Feng
2018-01-22
REV-ERBs (REV-ERBα and REV-ERBβ) are transcription repressors and circadian regulators. Previous investigations have shown that REV-ERBs repress the expression of target genes, including MMP9 and CX3CR1, in macrophages. Because MMP9 and CX3CR1 reportedly participate in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis, we inferred that REV-ERBs might play a role in osteoclastogenesis. In the present study, we found that the REV-ERBα level decreased significantly during RANKL-induced osteoclast differentiation from primary bone marrow-derived macrophages (BMMs). REV-ERBα knockdown by small interfering RNA in BMMs resulted in the enhanced formation of osteoclasts, whereas REV-ERBβ knockdown showed no effect on osteoclast differentiation. Moreover, the REV-ERB agonist SR9009 inhibited osteoclast differentiation and bone resorption. Intraperitoneal SR9009 administration prevented ovariectomy-induced bone loss; this effect was accompanied by decreased serum RANKL and C-terminal telopeptide of type I collagen levels and increased osteoprotegerin levels. Further investigation revealed that NF-κB and MAPK activation and nuclear factor of activated T cells, cytoplasmic 1, and c-fos expression were suppressed by SR9009. The level of reactive oxygen species was also decreased by SR9009, with NADPH oxidase subunits also being down-regulated. In addition, an expression microarray showed that FABP4, an intracellular lipid-binding protein, was up-regulated by REV-ERB agonism. BMS309403, an inhibitor of FABP4, partially prevented the suppression of osteoclastogenesis by SR9009 through stabilizing phosphorylation of p65. To summarize, our results proved that the REV-ERB agonism inhibited osteoclastogenesis partially via FABP4 up-regulation.-Song, C., Tan, P., Zhang, Z., Wu, W., Dong, Y., Zhao, L., Liu, H., Guan, H., Li, F. REV-ERBs agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
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Suppression of atherosclerosis by synthetic REV-ERB agonist
Sitaula, Sadichha; Billon, Cyrielle; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.
2015-01-01
The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. PMID:25800870
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Giuberti, Cristiane dos Santos; Boratto, Fernanda Alves; Degobert, Ghania; Silveira, Josianne Nicácio; Oliveira, Mônica Cristina
2013-09-01
Recent studies using long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) have resulted in a formulation with improved pharmacokinetic, toxicity and tumor localization properties. In this study, SpHL-CDDP were prepared in both laboratory and pilot scales. This study evaluated the possibility of using the dehydration-rehydration method, as well as using alternative organic solvents (ethyl acetate/ethanol mixtures at 2:1 and 1:1 volume ratios), for the preparation of liposomes by the reverse-phase evaporation (REV) method. The influence of different concentrations of cisplatin (CDDP) (2.0, 1.0, 0.5 and 0.25 mg/mL) on the entrapment percentage and size of SpHL-CDDP was also investigated. In addition, carbohydrates were tested as cryoprotectants in a freeze-thaw study as a pretest to screen the type to be used in the freeze-drying process. A decrease in the encapsulation percentage of CDDP and an increase in the vesicle diameter could be observed for both liposome formulations prepared with ethyl acetate:ethanol mixtures, as compared with REV liposomes prepared with ethyl ether. It is important to note that after applying either quick or slow cooling, the mean diameter of SpHL (empty liposomes) proved to be similar when in the presence of cryoprotectants. In sum, the optimal processing conditions were achieved when using a 0.5 mg/mL CDDP solution, ethyl ether and the REV method, resulting in liposomal dispersions of mean diameters and homogeneities that were deemed suitable for intravenous administration.
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Ensembles of physical states and random quantum circuits on graphs
NASA Astrophysics Data System (ADS)
Hamma, Alioscia; Santra, Siddhartha; Zanardi, Paolo
2012-11-01
In this paper we continue and extend the investigations of the ensembles of random physical states introduced in Hamma [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.109.040502 109, 040502 (2012)]. These ensembles are constructed by finite-length random quantum circuits (RQC) acting on the (hyper)edges of an underlying (hyper)graph structure. The latter encodes for the locality structure associated with finite-time quantum evolutions generated by physical, i.e., local, Hamiltonians. Our goal is to analyze physical properties of typical states in these ensembles; in particular here we focus on proxies of quantum entanglement as purity and α-Renyi entropies. The problem is formulated in terms of matrix elements of superoperators which depend on the graph structure, choice of probability measure over the local unitaries, and circuit length. In the α=2 case these superoperators act on a restricted multiqubit space generated by permutation operators associated to the subsets of vertices of the graph. For permutationally invariant interactions the dynamics can be further restricted to an exponentially smaller subspace. We consider different families of RQCs and study their typical entanglement properties for finite time as well as their asymptotic behavior. We find that area law holds in average and that the volume law is a typical property (that is, it holds in average and the fluctuations around the average are vanishing for the large system) of physical states. The area law arises when the evolution time is O(1) with respect to the size L of the system, while the volume law arises as is typical when the evolution time scales like O(L).
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Anthropology for the Classroom. The Social Science Teacher; Volume 3 Number 1, 1973.
ERIC Educational Resources Information Center
Townley, Charles, Ed.
This report of a conference attended by teachers and anthropologists concerns itself with the desirability and practicalities of teaching anthropology at the elementary and secondary levels in Britain. The papers reflect the varied objectives of a group trying to introduce a new element into school curricula. The president of the Royal…
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Project Thrive. Ways and Means: Strategies for Solving Classroom Problems. Volume I.
ERIC Educational Resources Information Center
Richards, Merle; Biemiller, Andrew
Strategies are delineated for solving elementary school classroom problems. After an introductory chapter, chapter 2 reviews problems cited by 24 kindergarten, Grade 1, and Grade 2 teachers and the strategies chosen as likely solutions to the problems. Strategies later found to be unsuccessful are discussed if they illustrate the nature of the…
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The Marketplace for Educational Testing. NBETPP Statements, Volume 2, Number 3.
ERIC Educational Resources Information Center
Clarke, Marguerite; Madaus, George; Horn, Catherine; Ramos, Miguel
This paper considers the size of the marketplace for education testing. The discussion is focused on commercial standardized achievement tests produced for the elementary and secondary market, the "Elhi" market. A few testing companies now account for the bulk of the test sales in the Elhi market, but it is difficult to obtain exact…
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Futures Information Interchange Newsletter; Volume 3, Number 2 and 3, December 1974 and April 1975.
ERIC Educational Resources Information Center
Massachusetts Univ., Amherst. School of Education.
The Futures Information Interchange Newsletters (No. 2 and 3) include a collection of practical teaching methods and learning activities for introducing future studies in the elementary and secondary classroom. Two lead articles offer new insights into future studies. In "Dilemmas of a Futurist" Fran Koster discusses some of the stresses unique to…
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Foundation Mathematics for the Physical Sciences
NASA Astrophysics Data System (ADS)
Riley, K. F.; Hobson, M. P.
2011-03-01
1. Arithmetic and geometry; 2. Preliminary algebra; 3. Differential calculus; 4. Integral calculus; 5. Complex numbers and hyperbolic functions; 6. Series and limits; 7. Partial differentiation; 8. Multiple integrals; 9. Vector algebra; 10. Matrices and vector spaces; 11. Vector calculus; 12. Line, surface and volume integrals; 13. Laplace transforms; 14. Ordinary differential equations; 15. Elementary probability; Appendices; Index.
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The Center for In-Service Education. Final Evaluation Report. Volume II. Part 1.
ERIC Educational Resources Information Center
Tennessee State Dept. of Education, Nashville.
This is an overview of the extensive in-service education inventory conducted as an integral portion of the planning contract for Models for In-Service Education supported by the Tennessee State Department of Education under Title III, Elementary and Secondary Education Act. The narrative descriptions are free of extensive statistical references…
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Science Books, A Quarterly Review, Volume 8 Number 2.
ERIC Educational Resources Information Center
American Association for the Advancement of Science, Washington, DC.
This quarterly journal reviews books in different science fields which could be used by teachers in elementary school, secondary school, and in the first two years of college. Not only are the textbooks reviewed, but trade books and reference works in pure and applied sciences are included. Annotations are listed in order of Dewey Decimal…
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Behind the Wall of China. Young Discovery Library Series: 42.
ERIC Educational Resources Information Center
Busuttil, Joelle
This book is part of an international series developed as a collaboration among the author, the illustrator, an advisory group of elementary school teachers and an aademic specialist on the subject. This volume provides in brief and simple terms some facts about the geography, history, and daily life of China. Some of the questions this book seeks…
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ERIC Educational Resources Information Center
Saad, Ismail, Comp.
This 123-item bibliography with English abstracts of recent books and articles on various aspects of Pakistan education includes a special section on new education policy. Emphasis is placed on elementary, secondary, and higher education, history of education, literature for children, science education, sociology, teacher training, and women's…
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ERIC Educational Resources Information Center
Di Biase, Bruno; And Others
The status of the Italian language in Australia, particularly in the educational system at all levels, in Australian society in general, and in trade, technology, and tourism is discussed in this report. It begins with a description of the teaching of Italian in elementary, secondary, higher, adult/continuing, and teacher education. Trends are…
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Missouri Journal of Research in Music Education, 1972-1976.
ERIC Educational Resources Information Center
Hilton, Lewis B., Ed.
1976-01-01
This journal is devoted to the needs and interests of the school and college music teachers of Missouri and the United States. Articles in Volume 3, Number 1 are: "The Parker Road Project: An Experiment of the Effects of Young Audience Concerts and a Related Curriculum on the Cognitive and Affective Development of Elementary School…
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ERIC Educational Resources Information Center
Smith, M. Sherry; And Others
The first of six volumes about Project CHANGE (Concepts of Handicaps and Attitudes Need Guidance and Education), a curriculum designed to improve elementary aged children's attitudes toward the disabled, presents information on installation and management of the inservice teacher training component, audiovisual materials for the teacher training…
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Should Cursive Handwriting Still Be Taught in Schools? Information Capsule. Volume 0916
ERIC Educational Resources Information Center
Blazer, Christie
2010-01-01
Elementary school students spend less time learning cursive handwriting than they did in years past. The declining emphasis on cursive writing has been attributed to the increasing use of technology, the growing proportion of class time spent preparing for standardized tests, and the perception that the time students spend learning to write in…
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Teaching about U.S. History: A Comparative Approach, 33 Activities. History Series, Volume 2.
ERIC Educational Resources Information Center
Smith, Gary R.
This book contains 33 supplementary activities on U.S. history. Although the activities were written for junior and senior high school students, most activities are adaptable for use with elementary school students also. The activities attempt to develop skills in three areas: (1) discovery skills (collecting, analyzing, and evaluating data;…
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Student Solution Manual for Foundation Mathematics for the Physical Sciences
NASA Astrophysics Data System (ADS)
Riley, K. F.; Hobson, M. P.
2011-03-01
1. Arithmetic and geometry; 2. Preliminary algebra; 3. Differential calculus; 4. Integral calculus; 5. Complex numbers and hyperbolic functions; 6. Series and limits; 7. Partial differentiation; 8. Multiple integrals; 9. Vector algebra; 10. Matrices and vector spaces; 11. Vector calculus; 12. Line, surface and volume integrals; 13. Laplace transforms; 14. Ordinary differential equations; 15. Elementary probability; Appendix.
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Teaching Information & Technology Skills: The Big6[TM] in Secondary Schools.
ERIC Educational Resources Information Center
Eisenberg, Michael B.; Berkowitz, Robert E.
This companion volume to a previous work focusing on the Big6 Approach in elementary schools provides secondary school classroom teachers, teacher-librarians, and technology teachers with the background and tools necessary to implement an integrated Big6 program. The first part of this book explains the Big6 approach and the rationale behind it.…
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ERIC Educational Resources Information Center
Shumm, Jeanne Shay
This book offers guidelines for elementary school teachers for making adaptations in reading and mathematics instruction for students with mild disabilities in the general education classroom. Following an introductory chapter, Chapter 1 presents eight principles for materials adaption organized according to the acronym FLEXIBLE: F-feasible…
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The 4M companY: Make Mine Metric Mission! Sixth Grade Teacher's Guide.
ERIC Educational Resources Information Center
Hawaii State Dept. of Education, Honolulu.
This is one of several teacher's guides for the 4M Company, a set of materials for teaching metric concepts and computation skills to elementary school students. Included in the guide are sections on needed materials, metric symbols, length, perimeter, area, volume, capacity, mass (weight), decimals, conversion between metric units, temperature,…
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ADCIS Conference Proceedings (27th, New Orleans, Louisiana, February 3-6, 1986).
ERIC Educational Resources Information Center
Association for the Development of Computer-based Instructional Systems.
The 52 papers in this volume, which represent recent research and applications in the field of computer-based instruction, are grouped under 10 general topic areas: (1) computer-based training; (2) elementary, secondary, junior college, and math education; (3) health; (4) home economics; (5) implementation; (6) mini-microcomputers; (7) PILOT; (8)…
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Studies in Mathematics, Volume V. Concepts of Informal Geometry. Preliminary Edition.
ERIC Educational Resources Information Center
Anderson, Richard D.
The main purpose of this book is to provide background material in geometry for teachers or prospective teachers who know little or no geometry. It should be suitable as a text for a one-semester course for teachers of junior high school or upper elementary school students. Chapters contain developmental material and exercises. Chapters include:…
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Energy levels for Ac-212 (Actinium-212)
NASA Astrophysics Data System (ADS)
Sukhoruchkin, S. I.; Soroko, Z. N.
This document is part of Subvolume C `Tables of Excitations of Proton- and Neutron-rich Unstable Nuclei' of Volume 19 `Nuclear States from Charged Particle Reactions' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms'. It provides energy levels for atomic nuclei of the isotope Ac-212 (actinium, atomic number Z = 89, mass number A = 212).
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The Emergence of the Common School in the U.S. Countryside. Mellen Studies in Education, Volume 36.
ERIC Educational Resources Information Center
Parkerson, Donald H.; Parkerson, Jo Ann
This book uses agricultural production statistics, school records, and records on births and families to provide a new interpretation of how agriculture's development in a market economy impacted the formation of elementary education during the 19th century. It provides background on the competing purposes underlying compulsory state-supported…
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ERIC Educational Resources Information Center
Richardson, Rita C.
The Connecting with Others program, initially developed to teach prosocial skills to special-needs students within regular classroom settings, offers an alternative strategy to classroom management and discipline through instruction in self-regulation skills and conflict resolution. The program for elementary grades consists of a K-2 volume and…
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Elements: Translating Theory into Practice. Volume 2, Number 7.
ERIC Educational Resources Information Center
Alberta Univ., Edmonton. Dept. of Elementary Education.
This monthly publication from Canada highlights a particular subject area of the curriculum in each issue. The March, 1971 newsletter is devoted to the social studies and contains the following articles: The Language of Social Studies, by Edna C. Wilson-Press; Some Questions About Values, by Joseph M. Kirman; Valuing in Elementary Social Studies:…
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Statistical Data and Narrative. End of Project Report, 1968-1971, Volume I.
ERIC Educational Resources Information Center
Western Nevada Regional Education Center, Lovelock.
In 1968, the Nevada State Department of Education initiated the establishment of 2 ESEA (Elementary and Secondary Education Act) Title III supplementary centers to aid rural Nevada schools in educational planning. The stated mission of the centers was to assist member school districts in developing new and/or improved educational programs as a…
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ERIC Educational Resources Information Center
Ellis, Edwin, Ed.
This volume of proceedings of the 1990 National Educational Computing Conference (NECC) provides a record of the state-of-the-art in the use of computing in a variety of educational settings. Special sessions, panels, projects, 153 abstracts, and 44 papers are reported here on subjects including: elementary and secondary educational software,…
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Physics in perspective. Volume 2, part A: The core subfields of physics
NASA Technical Reports Server (NTRS)
1972-01-01
Panel reports to the Survey Committee are presented to provide detailed technical background and documentation for committee findings, and to indicate the vitality and strength of the subfields of physics. Included are the core subfields of acoustics, optics, condensed matter, plasmas and fluids, atomic molecular and electron physics, nuclear physics, and elementary particle physics.
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A Course in Baluchi. Volume One.
ERIC Educational Resources Information Center
Barker, Muhammad Abd-al-Rahman; Mengal, Aqil Khan
This Baluchi text is intended for use in a one-year elementary course which meets (ideally) at least five classroom hours per week, with one or two more hours of practice in the language laboratory. It is designed to be used with a Baluchi native informant and a linguist, although the tapes prepared by the authors may, if necessary, replace the…
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Computer Assisted Learning. Book 1, The Teletype; Book 2, BASIC 1; Book 3, BASIC 2.
ERIC Educational Resources Information Center
Gawronski, Jane Donnelly
A series of three booklets provides elementary and secondary students who are participating in the Southeast Alternatives Program run by Special School District Number 1 in Minneapolis with some fundamental information about computers and their use. The first volume offers some general background on computers and describes the use of the teletype…
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Content Analysis of the "Professional School Counseling" Journal: The First Ten Years
ERIC Educational Resources Information Center
Falco, Lia D.; Bauman, Sheri; Sumnicht, Zachary; Engelstad, Alicia
2011-01-01
The authors conducted a content analysis of the articles published in the first 10 volumes of the "Professional School Counseling" (PSC) journal, beginning in October 1997 when "The School Counselor" merged with "Elementary School Counseling and Guidance". The analysis coded a total of 571 articles into 20 content categories. Findings address the…
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Spelling Test Generator--Volume 1: English. [CD-ROM].
ERIC Educational Resources Information Center
Aud, Joel; DeWolfe, Rosemary; Gintz, Christopher; Griswold, Scott; Hefter, Richard; Lowery, Adam; Richards, Maureen; Yi, Song Choi
This software product makes the manipulation of the more than 3000 most commonly used words in the English language easy to select and manipulate into various activities for elementary and middle school students. Users of the program have a variety of options: the program can automatically select words based on their age/grade level, frequency of…
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Thermodynamics of quantum spacetime histories
NASA Astrophysics Data System (ADS)
Smolin, Lee
2017-11-01
We show that the simplicity constraints, which define the dynamics of spin foam models, imply, and are implied by, the first law of thermodynamics, when the latter is applied to causal diamonds in the quantum spacetime. This result reveals an intimate connection between the holographic nature of gravity, as reflected by the Bekenstein entropy, and the fact that general relativity and other gravitational theories can be understood as constrained topological field theories. To state and derive this correspondence we describe causal diamonds in the causal structure of spin foam histories and generalize arguments given for the near horizon region of black holes by Frodden, Gosh and Perez [Phys. Rev. D 87, 121503 (2013); , 10.1103/PhysRevD.87.121503Phys. Rev. D 89, 084069 (2014); , 10.1103/PhysRevD.89.084069Phys. Rev. Lett. 107, 241301 (2011); , 10.1103/PhysRevLett.107.241301Phys. Rev. Lett.108, 169901(E) (2012)., 10.1103/PhysRevLett.108.169901] and Bianchi [arXiv:1204.5122.]. This allows us to apply a recent argument of Jacobson [Phys. Rev. Lett. 116, 201101 (2016).
10.1103/PhysRevLett.116.201101] to show that if a spin foam history has a semiclassical limit described in terms of a smooth metric geometry, that geometry satisfies the Einstein equations. These results suggest also a proposal for a quantum equivalence principle. -
Auerbach, Paul A.; Demple, Bruce
2010-01-01
Translesion synthesis (TLS) on DNA is a process by which potentially cytotoxic replication-blocking lesions are bypassed, but at the risk of increased mutagenesis. The exact in vivo role of the individual TLS enzymes in Saccharomyces cerevisiae has been difficult to determine from previous studies due to differing results from the variety of systems used. We have generated a series of S.cerevisiae strains in which each of the TLS-related genes REV1, REV3, REV7, RAD30 and POL32 was deleted, and in which chromosomal apyrimidinic sites were generated during normal cell growth by the activity of altered forms of human uracil-DNA glycosylase that remove undamaged cytosines or thymines. Deletion of REV1, REV3 or REV7 resulted in slower growth dependent on (rev3Δ and rev7Δ) or enhanced by (rev1Δ) expression of the mutator glycosylases and a nearly complete abolition of glycosylase-induced mutagenesis. Deletion of POL32 resulted in cell death when the mutator glycosylases were expressed and, in their absence, diminished spontaneous mutagenesis. RAD30 appeared to be unnecessary for mutagenesis in response to abasic sites, as deleting this gene caused no significant change in either the mutation rates or the mutational spectra due to glycosylase expression. PMID:19901007
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Quantum many-body effects in x-ray spectra efficiently computed using a basic graph algorithm
NASA Astrophysics Data System (ADS)
Liang, Yufeng; Prendergast, David
2018-05-01
The growing interest in using x-ray spectroscopy for refined materials characterization calls for an accurate electronic-structure theory to interpret the x-ray near-edge fine structure. In this work, we propose an efficient and unified framework to describe all the many-electron processes in a Fermi liquid after a sudden perturbation (such as a core hole). This problem has been visited by the Mahan-Noziéres-De Dominicis (MND) theory, but it is intractable to implement various Feynman diagrams within first-principles calculations. Here, we adopt a nondiagrammatic approach and treat all the many-electron processes in the MND theory on an equal footing. Starting from a recently introduced determinant formalism [Phys. Rev. Lett. 118, 096402 (2017), 10.1103/PhysRevLett.118.096402], we exploit the linear dependence of determinants describing different final states involved in the spectral calculations. An elementary graph algorithm, breadth-first search, can be used to quickly identify the important determinants for shaping the spectrum, which avoids the need to evaluate a great number of vanishingly small terms. This search algorithm is performed over the tree-structure of the many-body expansion, which mimics a path-finding process. We demonstrate that the determinantal approach is computationally inexpensive even for obtaining x-ray spectra of extended systems. Using Kohn-Sham orbitals from two self-consistent fields (ground and core-excited state) as input for constructing the determinants, the calculated x-ray spectra for a number of transition metal oxides are in good agreement with experiments. Many-electron aspects beyond the Bethe-Salpeter equation, as captured by this approach, are also discussed, such as shakeup excitations and many-body wave function overlap considered in Anderson's orthogonality catastrophe.
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Aligeti, Mounavya; Behrens, Ryan T.; Pocock, Ginger M.; Schindelin, Johannes; Dietz, Christian; Eliceiri, Kevin W.; Swanson, Chad M.; Malim, Michael H.; Ahlquist, Paul
2014-01-01
ABSTRACT Murine cells exhibit a profound block to HIV-1 virion production that was recently mapped to a species-specific structural attribute of the murine version of the chromosomal region maintenance 1 (mCRM1) nuclear export receptor and rescued by the expression of human CRM1 (hCRM1). In human cells, the HIV-1 Rev protein recruits hCRM1 to intron-containing viral mRNAs encoding the Rev response element (RRE), thereby facilitating viral late gene expression. Here we exploited murine 3T3 fibroblasts as a gain-of-function system to study hCRM1's species-specific role in regulating Rev's effector functions. We show that Rev is rapidly exported from the nucleus by mCRM1 despite only weak contributions to HIV-1's posttranscriptional stages. Indeed, Rev preferentially accumulates in the cytoplasm of murine 3T3 cells with or without hCRM1 expression, in contrast to human HeLa cells, where Rev exhibits striking en masse transitions between the nuclear and cytoplasmic compartments. Efforts to bias Rev's trafficking either into or out of the nucleus revealed that Rev encoding a second CRM1 binding domain (Rev-2xNES) or Rev-dependent viral gag-pol mRNAs bearing tandem RREs (GP-2xRRE), rescue virus particle production in murine cells even in the absence of hCRM1. Combined, these results suggest a model wherein Rev-associated nuclear export signals cooperate to regulate the number or quality of CRM1's interactions with viral Rev/RRE ribonucleoprotein complexes in the nucleus. This mechanism regulates CRM1-dependent viral gene expression and is a determinant of HIV-1's capacity to produce virions in nonhuman cell types. IMPORTANCE Cells derived from mice and other nonhuman species exhibit profound blocks to HIV-1 replication. Here we elucidate a block to HIV-1 gene expression attributable to the murine version of the CRM1 (mCRM1) nuclear export receptor. In human cells, hCRM1 regulates the nuclear export of viral intron-containing mRNAs through the activity of the viral Rev adapter protein that forms a multimeric complex on these mRNAs prior to recruiting hCRM1. We demonstrate that Rev-dependent gene expression is poor in murine cells despite the finding that, surprisingly, the bulk of Rev interacts efficiently with mCRM1 and is rapidly exported from the nucleus. Instead, we map the mCRM1 defect to the apparent inability of this factor to engage Rev multimers in the context of large viral Rev/RNA ribonucleoprotein complexes. These findings shed new light on HIV-1 gene regulation and could inform the development of novel antiviral strategies that target viral gene expression. PMID:25275125
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The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker
Triqueneaux, Gérard; Thenot, Sandrine; Kakizawa, Tomoko; Antoch, Marina P; Safi, Rachid; Takahashi, Joseph S; Delaunay, Franck; Laudet, Vincent
2013-01-01
Rev-erbα is a ubiquitously expressed orphan nuclear receptor which functions as a constitutive transcriptional repressor and is expressed in vertebrates according to a robust circadian rhythm. We report here that two Rev-erbα mRNA isoforms, namely Rev-erbα1 and Rev-erbα2, are generated through alternative promoter usage and that both show a circadian expression pattern in an in vitro system using serum-shocked fibroblasts. Both promoter regions P1 (Rev-erbα1) and P2 (Rev-erbα2) contain several E-box DNA sequences, which function as response elements for the core circadian-clock components: CLOCK and BMAL1. The CLOCK–BMAL1 heterodimer stimulates the activity of both P1 and P2 promoters in transient transfection assay by 3–6-fold. This activation was inhibited by the overexpression of CRY1, a component of the negative limb of the circadian transcriptional loop. Critical E-box elements were mapped within both promoters. This regulation is conserved in vertebrates since we found that the CLOCK–BMAL1 heterodimer also regulates the zebrafish Rev-erbα gene. In line with these data Rev-erbα circadian expression was strongly impaired in the livers of Clock mutant mice and in the pineal glands of zebrafish embryos treated with Clock and Bmal1 antisense oligonucleotides. Together these data demonstrate that CLOCK is a critical regulator of Rev-erbα circadian gene expression in evolutionarily distant vertebrates and suggest a role for Rev-erbα in the circadian clock output. PMID:15591021
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Matsushima, Takashi; Blumenfeld, Raphael
2017-03-01
The microstructural organization of a granular system is the most important determinant of its macroscopic behavior. Here we identify the fundamental factors that determine the statistics of such microstructures, using numerical experiments to gain a general understanding. The experiments consist of preparing and compacting isotropically two-dimensional granular assemblies of polydisperse frictional disks and analyzing the emergent statistical properties of quadrons-the basic structural elements of granular solids. The focus on quadrons is because the statistics of their volumes have been found to display intriguing universal-like features [T. Matsushima and R. Blumenfeld, Phys. Rev. Lett. 112, 098003 (2014)PRLTAO0031-900710.1103/PhysRevLett.112.098003]. The dependence of the structures and of the packing fraction on the intergranular friction and the initial state is analyzed, and a number of significant results are found. (i) An analytical formula is derived for the mean quadron volume in terms of three macroscopic quantities: the mean coordination number, the packing fraction, and the rattlers fraction. (ii) We derive a unique, initial-state-independent relation between the mean coordination number and the rattler-free packing fraction. The relation is supported numerically for a range of different systems. (iii) We collapse the quadron volume distributions from all systems onto one curve, and we verify that they all have an exponential tail. (iv) The nature of the quadron volume distribution is investigated by decomposition into conditional distributions of volumes given the cell order, and we find that each of these also collapses onto a single curve. (v) We find that the mean quadron volume decreases with increasing intergranular friction coefficients, an effect that is prominent in high-order cells. We argue that this phenomenon is due to an increased probability of stable irregularly shaped cells, and we test this using a herewith developed free cell analytical model. We conclude that, in principle, the microstructural characteristics are governed mainly by the packing procedure, while the effects of intergranular friction and initial states are details that can be scaled away. However, mechanical stability constraints suppress slightly the occurrence of small quadron volumes in cells of order ≥6, and the magnitude of this effect does depend on friction. We quantify in detail this dependence and the deviation it causes from an exact collapse for these cells. (vi) We argue that our results support strongly the view that ensemble granular statistical mechanics does not satisfy the uniform measure assumption of conventional statistical mechanics. Results (i)-(iv) have been reported in the aforementioned reference, and they are reviewed and elaborated on here.
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Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.
Cui, Gaofeng; Botuyan, Maria Victoria; Mer, Georges
2018-05-18
REV1 is an evolutionarily conserved translesion synthesis (TLS) DNA polymerase and an assembly factor key for the recruitment of other TLS polymerases to DNA damage sites. REV1-mediated recognition of ubiquitin in the proliferative cell nuclear antigen is thought to be the trigger for TLS activation. Here we report the solution NMR structure of a 108-residue fragment of human REV1 encompassing the two putative ubiquitin-binding motifs UBM1 and UBM2 in complex with ubiquitin. While in mammals UBM1 and UBM2 are both required for optimal association of REV1 with replication factories after DNA damage, we show that only REV1 UBM2 binds ubiquitin. Structure-guided mutagenesis in Saccharomyces cerevisiae further highlights the importance of UBM2 for REV1-mediated mutagenesis and DNA damage tolerance. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Defects, Tunneling, and EPR Spectra of Single-Molecule Magnets
2003-01-01
Caranin, Phys. Rev. Lett. 87, 187203 (2001); Phys. Rev. B 65, 094423 (2002). 19. A. Cornia, R. Sessoli, L. Sorace, D. Gatteschi , A. L. Barra, and C...Phys. Rev. B 64, 184426 (2001). 25. A. Mukhin, B. Gorshunov, M. Dressel, C. Sangregorio. and D. Gatteschi , Phys. Rev. B 63, 214411 (2001). 26. W
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RevManHAL: towards automatic text generation in systematic reviews.
Torres Torres, Mercedes; Adams, Clive E
2017-02-09
Systematic reviews are a key part of healthcare evaluation. They involve important painstaking but repetitive work. A major producer of systematic reviews, the Cochrane Collaboration, employs Review Manager (RevMan) programme-a software which assists reviewers and produces XML-structured files. This paper describes an add-on programme (RevManHAL) which helps auto-generate the abstract, results and discussion sections of RevMan-generated reviews in multiple languages. The paper also describes future developments for RevManHAL. RevManHAL was created in Java using NetBeans by a programmer working full time for 2 months. The resulting open-source programme uses editable phrase banks to envelop text/numbers from within the prepared RevMan file in formatted readable text of a chosen language. In this way, considerable parts of the review's 'abstract', 'results' and 'discussion' sections are created and a phrase added to 'acknowledgements'. RevManHAL's output needs to be checked by reviewers, but already, from our experience within the Cochrane Schizophrenia Group (200 maintained reviews, 900 reviewers), RevManHAL has saved much time which is better employed thinking about the meaning of the data rather than restating them. Many more functions will become possible as review writing becomes increasingly automated.
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Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
Han, Chang Woo; Jeong, Mi Suk; Jang, Se Bok
2017-09-16
Ras proteins are small GTPases that serve as master moderators of a large number of signaling pathways involved in various cellular processes. Activating mutations in Ras are found in about one-third of cancers. H-REV107, a K-Ras binding protein, plays an important role in determining K-Ras function. H-REV107 is a member of the HREV107 family of class II tumor suppressor genes and a growth inhibitory Ras target gene that suppresses cellular growth, differentiation, and apoptosis. Expression of H-REV107 was strongly reduced in about 50% of human carcinoma cell lines. However, the specific molecular mechanism by which H-REV107 inhibits Ras is still unknown. In the present study, we suggest that H-REV107 forms a strong complex with activating oncogenic mutation Q61H K-Ras from various biochemical binding assays and modeled structures. In addition, the interaction sites between K-Ras and H-REV107 were predicted based on homology modeling. Here, we found that some structure-based mutants of the K-Ras disrupted the complex formation with H-REV107. Finally, a novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided. Copyright © 2017 Elsevier Inc. All rights reserved.
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The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.
Roos, Wynand Paul; Tsaalbi-Shtylik, Anastasia; Tsaryk, Roman; Güvercin, Fatma; de Wind, Niels; Kaina, Bernd
2009-10-01
Temozolomide and fotemustine, representing methylating and chloroethylating agents, respectively, are used in the treatment of glioma and malignant melanoma. Because chemoresistance of these tumors is a common phenomenon, identification of the underlying mechanisms is needed. Here we show that Rev3L, the catalytic subunit of the translesion DNA polymerase zeta, mediates resistance to both temozolomide and fotemustine. Rev3L knockout cells are hypersensitive to both agents. It is remarkable that cells heterozygous for Rev3L showed an intermediate sensitivity. Rev3L is not involved in the tolerance of the toxic O6-methylguanine lesion. However, a possible role of Rev3L in the tolerance of O6-chloroethylguanine or the subsequently formed N1-guanine-N3-cytosine interstrand cross-link is shown. Rev3L had no influence on base excision repair (BER) of the N-alkylation lesions but is very likely to be involved in the tolerance of N-alkylations or apurinic/apyrimidinic sites originating from them. We also show that Rev3L exerts its protective effect in replicating cells and that loss of Rev3L leads to a significant increase in DNA double-strand breaks after temozolomide and fotemustine treatment. These data show that Rev3L contributes to temozolomide and fotemustine resistance, thus acting in concert with O6-methylguanine-DNA methyltransferase, BER, mismatch repair, and double-strand break repair in defense against simple alkylating anticancer drugs.
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Issa, Mohammad Nouh; Ashhab, Yaqoub
2016-09-22
Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard. The comparative analyses revealed 32 genetic alterations (30 SNPs, 1 single-bp insertion and 1 single-bp deletion) that are exclusively present in the Rev.1 genome. In silico analyses showed that 9 out of the 17 non-synonymous mutations are deleterious. Three ABC transporters are among the disrupted genes that can be linked to virulence attenuation. Out of the 32 mutations, 11 Rev.1 specific markers were selected to test their potential to discriminate Rev.1 using a bi-directional allele-specific PCR assay. Six markers were able to distinguish between Rev.1 and a set of control strains. We succeeded in identifying a panel of 32 genome-specific markers of the B. melitensis Rev.1 vaccine strain. Extensive in silico analysis showed that a considerable number of these mutations could severely affect the function of the associated genes. In addition, some of the discovered markers were able to discriminate Rev.1 strain from a group of control strains using practical PCR tests that can be applied in resource-limited settings. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Höhna, Sebastian; Landis, Michael J.
2016-01-01
Programs for Bayesian inference of phylogeny currently implement a unique and fixed suite of models. Consequently, users of these software packages are simultaneously forced to use a number of programs for a given study, while also lacking the freedom to explore models that have not been implemented by the developers of those programs. We developed a new open-source software package, RevBayes, to address these problems. RevBayes is entirely based on probabilistic graphical models, a powerful generic framework for specifying and analyzing statistical models. Phylogenetic-graphical models can be specified interactively in RevBayes, piece by piece, using a new succinct and intuitive language called Rev. Rev is similar to the R language and the BUGS model-specification language, and should be easy to learn for most users. The strength of RevBayes is the simplicity with which one can design, specify, and implement new and complex models. Fortunately, this tremendous flexibility does not come at the cost of slower computation; as we demonstrate, RevBayes outperforms competing software for several standard analyses. Compared with other programs, RevBayes has fewer black-box elements. Users need to explicitly specify each part of the model and analysis. Although this explicitness may initially be unfamiliar, we are convinced that this transparency will improve understanding of phylogenetic models in our field. Moreover, it will motivate the search for improvements to existing methods by brazenly exposing the model choices that we make to critical scrutiny. RevBayes is freely available at http://www.RevBayes.com. [Bayesian inference; Graphical models; MCMC; statistical phylogenetics.] PMID:27235697
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Höhna, Sebastian; Landis, Michael J; Heath, Tracy A; Boussau, Bastien; Lartillot, Nicolas; Moore, Brian R; Huelsenbeck, John P; Ronquist, Fredrik
2016-07-01
Programs for Bayesian inference of phylogeny currently implement a unique and fixed suite of models. Consequently, users of these software packages are simultaneously forced to use a number of programs for a given study, while also lacking the freedom to explore models that have not been implemented by the developers of those programs. We developed a new open-source software package, RevBayes, to address these problems. RevBayes is entirely based on probabilistic graphical models, a powerful generic framework for specifying and analyzing statistical models. Phylogenetic-graphical models can be specified interactively in RevBayes, piece by piece, using a new succinct and intuitive language called Rev. Rev is similar to the R language and the BUGS model-specification language, and should be easy to learn for most users. The strength of RevBayes is the simplicity with which one can design, specify, and implement new and complex models. Fortunately, this tremendous flexibility does not come at the cost of slower computation; as we demonstrate, RevBayes outperforms competing software for several standard analyses. Compared with other programs, RevBayes has fewer black-box elements. Users need to explicitly specify each part of the model and analysis. Although this explicitness may initially be unfamiliar, we are convinced that this transparency will improve understanding of phylogenetic models in our field. Moreover, it will motivate the search for improvements to existing methods by brazenly exposing the model choices that we make to critical scrutiny. RevBayes is freely available at http://www.RevBayes.com [Bayesian inference; Graphical models; MCMC; statistical phylogenetics.]. © The Author(s) 2016. Published by Oxford University Press, on behalf of the Society of Systematic Biologists.
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Svicher, Valentina; Alteri, Claudia; D'Arrigo, Roberta; Laganà, Alessandro; Trignetti, Maria; Lo Caputo, Sergio; Callegaro, Anna Paola; Maggiolo, Franco; Mazzotta, Francesco; Ferro, Alfredo; Dimonte, Salvatore; Aquaro, Stefano; di Perri, Giovanni; Bonora, Stefano; Tommasi, Chiara; Trotta, Maria Paola; Narciso, Pasquale; Antinori, Andrea; Perno, Carlo Federico; Ceccherini-Silberstein, Francesca
2009-07-01
The gp41-encoding sequence of the env gene contains in two separate regions the Rev-responsive elements (RRE) and the alternative open reading frame of the second exon of the regulatory protein Rev. The binding of Rev to the RRE allows the transport of unspliced/singly spliced viral mRNAs out of the nucleus, an essential step in the life cycle of human immunodeficiency virus type 1 (HIV-1). In this study, we have investigated whether the fusion-inhibitor enfuvirtide (ENF) can induce mutations in Rev and if these mutations correlate with the classical ENF resistance gp41 mutations and with viremia and CD4 cell count. Specific Rev mutations were positively associated with ENF treatment and significantly correlated with classical ENF resistance gp41 mutations. In particular, a cluster was observed for the Rev mutations E57A (E57A(rev)) and N86S(rev) with the ENF resistance gp41 mutations Q40H (Q40H(gp41)) and L45M(gp41). In addition, the presence at week 48 of the E57A(rev) correlates with a significant viremia increase from baseline to week 48 and with a CD4 cell count loss from baseline to week 48. By modeling the RRE structure, we found that the Q40(gp41) and L45(gp41) codons form complementary base pairs in a region of the RRE involved in Rev binding. The conformation of this Rev-binding site is disrupted when Q40H(gp41) and L45M(gp41) occur alone while it is restored when both mutations are present. In conclusion, our study shows that ENF pressure may also affect both Rev and RRE structures and can provide an excellent example of compensatory evolution. This highlights the multiple roles of ENF (and perhaps other entry inhibitors) in modulating the correct interplay between the different HIV-1 genes and proteins during the HIV-1 life cycle.
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Image-based modeling of the flow transition from a Berea rock matrix to a propped fracture
NASA Astrophysics Data System (ADS)
Sanematsu, P.; Willson, C. S.; Thompson, K. E.
2013-12-01
In the past decade, new technologies and advances in horizontal hydraulic fracturing to extract oil and gas from tight rocks have raised questions regarding the physics of the flow and transport processes that occur during production. Many of the multi-dimensional details of flow from the rock matrix into the fracture and within the proppant-filled fracture are still unknown, which leads to unreliable well production estimations. In this work, we use x-ray computed micro tomography (XCT) to image 30/60 CarboEconoprop light weight ceramic proppant packed between berea sandstone cores (6 mm in diameter and ~2 mm in height) under 4000 psi (~28 MPa) loading stress. Image processing and segmentation of the 6 micron voxel resolution tomography dataset into solid and void space involved filtering with anisotropic diffusion (AD), segmentation using an indicator kriging (IK) algorithm, and removal of noise using a remove islands and holes program. Physically-representative pore network structures were generated from the XCT images, and a representative elementary volume (REV) was analyzed using both permeability and effective porosity convergence. Boundary conditions were introduced to mimic the flow patterns that occur when fluid moves from the matrix into the proppant-filled fracture and then downstream within the proppant-filled fracture. A smaller domain, containing Berea and proppants close to the interface, was meshed using an in-house unstructured meshing algorithm that allows different levels of refinement. Although most of this domain contains proppants, the Berea section accounted for the majority of the elements due to mesh refinement in this region of smaller pores. A finite element method (FEM) Stokes flow model was used to provide more detailed insights on the flow transition from rock matrix to fracture. Results using different pressure gradients are used to describe the flow transition from the Berea rock matrix to proppant-filled fracture.
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NASA Astrophysics Data System (ADS)
Kohanpur, A. H.; Chen, Y.; Valocchi, A. J.; Tudek, J.; Crandall, D.
2016-12-01
CO2-brine flow in deep natural rocks is the focus of attention in geological storage of CO2. Understanding rock/flow properties at pore-scale is a vital component in field-scale modeling and prediction of fate of injected CO2. There are many challenges in working at the pore scale, such as size and selection of representative elementary volume (REV), particularly for material with complex geometry and heterogeneity, and the high computational costs. These issues factor into trade-offs that need to be made in choosing and applying pore-scale models. On one hand, pore-network modeling (PNM) simplifies the geometry and flow equations but can provide characteristic curves on fairly large samples. On the other hand, the lattice Boltzmann method (LBM) solves Navier-Stokes equations on the real geometry but is limited to small samples due to its high computational costs. Thus, both methods have some advantages but also face some challenges, which warrants a more detailed comparison and evaluation. In this study, we used industrial and micro-CT scans of actual reservoir rock samples to characterize pore structure at different resolutions. We ran LBM models directly on the characterized geometry and PNM on the equivalent 3D extracted network to determine single/two-phase flow properties during drainage and imbibition processes. Specifically, connectivity, absolute permeability, relative permeability curve, capillary pressure curve, and interface location are compared between models. We also did simulations on several subsamples from different locations including different domain sizes and orientations to encompass analysis of heterogeneity and isotropy. This work is primarily supported as part of the Center for Geologic Storage of CO2, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science and partially supported by the International Institute for Carbon-Neutral Energy Research (WPI-I2CNER) based at Kyushu University, Japan.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-13
...] Determination That REV-EYES (Dapiprazole Hydrochloride Ophthalmic Solution), 0.5%, Was Not Withdrawn From Sale.... SUMMARY: The Food and Drug Administration (FDA) has determined that REV-EYES (dapiprazole hydrochloride... CFR 314.161)). FDA may not approve an ANDA that does not refer to a listed drug. REV-EYES (dapiprazole...
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Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas
New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-18
... NUCLEAR REGULATORY COMMISSION [NRC-2010-0080] NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3...: ``NUREG-0654/FEMA-REP-1, Rev. 1, Supplement 3, Guidance for Protective Action Recommendations for General... the existing guidance contained in Supplement 3 to NUREG- 0654/FEMA-REP-1, Rev. 1, ``Criteria for...
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ERIC Educational Resources Information Center
Russell, William Benedict, III, Ed.
2015-01-01
The "International Society for the Social Studies (ISSS) Annual Conference Proceedings" is a peer-reviewed professional publication published once a year following the annual conference. The following papers are included in the 2015 proceedings: (1) Local History and Local Culture at the Core of Elementary Social Studies Curriculum (C.…
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ERIC Educational Resources Information Center
Nanlohy, Phil, Ed.
1993-01-01
The 43 papers in this collection were presented at the Australian Council for Computers in Education 1993 annual conference. The papers focus on research and scholarship in the use of computers at the elementary, secondary, and higher education levels. The papers address the following aspects of the use of computers in education: (1) theoretical…
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Turning Kids On to Science in the Home: Forces & Motion. Book 3.
ERIC Educational Resources Information Center
Liem, Tik L.
This is the third book in a sequence of four volumes written and designed for parents of students of science, particularly for those at the lower and upper elementary and junior high or intermediate level, senior high students, college students preparing to teach science, and all those individuals who are interested in science and the application…
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Turning Kids On to Science in the Home: Our Environment. Book 1.
ERIC Educational Resources Information Center
Liem, Tik L.
This is the first book in a sequence of four volumes written and designed for parents of students of science, particularly for those at the lower and upper elementary and junior high or intermediate level, senior high students, college students preparing to teach science, and all those individuals who are interested in science and the application…
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ERIC Educational Resources Information Center
Ireland, Vera M.
As an integral part of the library improvement program of the Atlanta Public School System, the library aide program, funded under Title I of the Elementary and Secondary Education Act, was developed to relieve librarians of routine clerical and nonprofessional duties. In order to evaluate the inservice training and library aide activities,…
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Averages, Areas and Volumes; Cambridge Conference on School Mathematics Feasibility Study No. 45.
ERIC Educational Resources Information Center
Cambridge Conference on School Mathematics, Newton, MA.
Presented is an elementary approach to areas, columns and other mathematical concepts usually treated in calculus. The approach is based on the idea of average and this concept is utilized throughout the report. In the beginning the average (arithmetic mean) of a set of numbers is considered and two properties of the average which often simplify…
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ERIC Educational Resources Information Center
Donovan, John D.; And Others
The more important factors responsible for the contemporary crisis in Catholic schools throughout the United States are identified. The identification is made through discussions of the following topics: (1) An overview of the socio-historic and socio-religious forces responsible for the establishment and growth of the Catholic elementary and…
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Games and Activities, Volume 1, Part A: Drama; Levels A-B (Grades 1 and 2).
ERIC Educational Resources Information Center
Oregon Univ., Eugene. Oregon Elementary English Project.
Developed by the Oregon Elementary English Project, this curriculum unit contains drama activities intended for grades one and two. The activities are not ordered in a definite sequence; rather they are meant to be used as the opportunity arises. The activities are divided into (1) exercises based on puppetry, including a puppet hunt, the making…
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ERIC Educational Resources Information Center
Long, Sandra; And Others
Part of a curriculum series for academically gifted elementary students in the area of reading, the document presents objectives and activities for language arts instruction. There are three major objectives: (1) recognizing persuasive use of words, vague and imprecise words, multiple meanings conveyed by a single word, and propaganda techniques;…
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ERIC Educational Resources Information Center
Graber, Kim C.; Woods, Amelia Mays; Castelli, Darla M.
2007-01-01
Grounded in social cognitive and self-determination theory, one purpose of the large-scale investigation reported in this volume was to determine whether elementary-aged children (7-12 years old) are progressing toward attainment of the psychomotor assessments that have been recommended for predicting achievement of National Association for Sport…
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ERIC Educational Resources Information Center
Suydam, Marilyn N.; Riedesel, C. Alan
To gather the information for this section, visits were made to each of ten major curriculum development projects. These were selected because of the impact which each has had on curriculum reform--past, present, and future. It was not possible to visit every project, and several of the more significant ones, such as the Greater Cleveland…
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ERIC Educational Resources Information Center
Harrison, Laurie R.
This volume is the third module, "Parent Involvement," of the evaluation report documenting how states met the requirements of Title I of the Elementary and Secondary Education Act of 1965, as amended in 1978, and identifying exemplary State management practices and documents. The module begins with a history of parent involvement under…
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Coco Nut Meets the Gadget Maker. Volume 1.
ERIC Educational Resources Information Center
Thomson, P.
The adventures of Coco Nut, a coconut which has fallen from a palm tree in Florida, are illustrated in this booklet for elementary school students. His fall into a canal and ensuing encounters with dead and alive fish and a gadget maker (industry) are used to portray the effects of water pollution. What man can do to stop such pollution and…
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ERIC Educational Resources Information Center
Bloom, Benjamin S.
Twelve chapters describe an 18-nation study of educational attainment at the elementary and secondary school levels. Professional researchers participated in the project, developed through UNESCO and conducted under the auspices of educational research centers in Australia, Belgium, Chile, England, the Federal Republic of Germany, Finland, France,…
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ERIC Educational Resources Information Center
Matthews, Mary Elizabeth
2013-01-01
This literature review examines the models, theories, and research in mathematics education that are informed by Lee S. Shulman's construct, Pedagogical Content Knowledge. The application of the concept differs in nature and volume across levels of schooling. The research includes substantial work at the elementary level, fewer studies at the…
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Elementary and Secondary Civil Rights Survey, 1984. District Summary Volumes 1 and 2.
ERIC Educational Resources Information Center
DBS Corp., Arlington, VA.
This 1984 survey was conducted to obtain data on the characteristics of public school students in the 50 states and the District of Columbia. The 3,510 school districts selected to participate were statistically sampled from approximately 16,000 U.S. school districts, and the schools within the selected districts were subsampled: (1) all special…
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ERIC Educational Resources Information Center
Connors, James J., Ed.; Murphy, Tim H., Ed.
The following are among the 51 papers and 7 poster sessions included: "Agriculture in the Classroom" (Hillison); "Effects of an Elementary Agri-Science Program on Student Perceptions of and Performance in Agriculture and Science" (Howell); "Current Status of Preservice Teacher Education Programs in Agriculture" (Swortzel); "Problems and Challenges…
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ERIC Educational Resources Information Center
Gans, Connie; And Others
The work-study guide is the third volume in the advanced level of a career education curriculum for elementary-secondary migrant children. Complementing the secondary level job information text and a workbook about decision making and self-awareness, the work-study guide is designed to accompany work exploration and experience programs. It…
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ERIC Educational Resources Information Center
Holt, Daniel D., Ed.
Essays on cooperative learning focus on the use of this strategy to address the special needs of linguistically and culturally diverse student groups in elementary and secondary education. The volume contains several essays on theory, principles, and techniques of cooperative learning and a series of model instructional units for a variety of…
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ERIC Educational Resources Information Center
Far West Lab. for Educational Research and Development, San Francisco, CA.
This report, the second in a series of six, presents the findings of evaluative studies of six Level I Model Technology School sites which were conducted as part of Phase II of the California Educational Technology Assessment Program. The project sites are: Alhambra City School District (two schools); Cupertino Union Elementary District and…
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Chemical pressure tuning of URu2Si2 via isoelectronic substitution of Ru with Fe
NASA Astrophysics Data System (ADS)
Das, Pinaki; Kanchanavatee, N.; Helton, J. S.; Huang, K.; Baumbach, R. E.; Bauer, E. D.; White, B. D.; Burnett, V. W.; Maple, M. B.; Lynn, J. W.; Janoschek, M.
2015-02-01
We have used specific heat and neutron diffraction measurements on single crystals of URu2 -xFexSi2 for Fe concentrations x ≤0.7 to establish that chemical substitution of Ru with Fe acts as "chemical pressure" Pc h as previously proposed by Kanchanavatee et al. [Phys. Rev. B 84, 245122 (2011), 10.1103/PhysRevB.84.245122] based on bulk measurements on polycrystalline samples. Notably, neutron diffraction reveals a sharp increase of the uranium magnetic moment at x =0.1 , reminiscent of the behavior at the "hidden order" to large-moment-antiferromagnetic phase transition observed at a pressure Px≈0.5 -0.7 GPa in URu2Si2 . Using the unit-cell volume determined from our measurements and an isothermal compressibility κT=5.2 ×10-3 GPa-1 for URu2Si2 , we determine the chemical pressure Pc h in URu2 -xFexSi2 as a function of x . The resulting temperature (T )-chemical pressure (Pc h) phase diagram for URu2 -xFexSi2 is in agreement with the established temperature (T )-external pressure (P ) phase diagram of URu2Si2 .
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Discrete Functions of Nuclear Receptor Rev-erbα Couple Metabolism to the Clock
Zhang, Yuxiang; Fang, Bin; Emmett, Matthew J.; Damle, Manashree; Sun, Zheng; Feng, Dan; Armour, Sean M.; Remsberg, Jarrett R.; Jager, Jennifer; Soccio, Raymond E.; Steger, David J.; Lazar, Mitchell A.
2015-01-01
SUMMARY Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erbα, a transcription factor (TF) that functions both as a core repressive component of the cell autonomous clock and as a regulator of metabolic genes. Here we show that Rev-erbα modulates the clock and metabolism by different genomic mechanisms. Clock control requires Rev-erbα to bind directly to the genome at its cognate sites, where it competes with activating ROR TFs. By contrast, Rev-erbα regulates metabolic genes primarily by recruiting the HDAC3 corepressor to sites to which it is tethered by cell type-specific transcription factors. Thus, direct competition between Rev-erbα and ROR TFs provides a universal mechanism for self-sustained control of molecular clock across all tissues, whereas Rev-erbα utilizes lineage-determining factors to convey a tissue-specific epigenomic rhythm that regulates metabolism tailored to the specific need of that tissue. PMID:26044300
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GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock.
Zhang, Yuxiang; Fang, Bin; Emmett, Matthew J; Damle, Manashree; Sun, Zheng; Feng, Dan; Armour, Sean M; Remsberg, Jarrett R; Jager, Jennifer; Soccio, Raymond E; Steger, David J; Lazar, Mitchell A
2015-06-26
Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erbα, a transcription factor (TF) that functions both as a core repressive component of the cell-autonomous clock and as a regulator of metabolic genes. Here, we show that Rev-erbα modulates the clock and metabolism by different genomic mechanisms. Clock control requires Rev-erbα to bind directly to the genome at its cognate sites, where it competes with activating ROR TFs. By contrast, Rev-erbα regulates metabolic genes primarily by recruiting the HDAC3 co-repressor to sites to which it is tethered by cell type-specific transcription factors. Thus, direct competition between Rev-erbα and ROR TFs provides a universal mechanism for self-sustained control of the molecular clock across all tissues, whereas Rev-erbα uses lineage-determining factors to convey a tissue-specific epigenomic rhythm that regulates metabolism tailored to the specific need of that tissue. Copyright © 2015, American Association for the Advancement of Science.
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Vanishing Hall conductance in the phase-glass Bose metal at zero temperature
NASA Astrophysics Data System (ADS)
May-Mann, Julian; Phillips, Philip W.
2018-01-01
Motivated in part by numerical simulations [H. G. Katzgraber and A. P. Young, Phys. Rev. B 66, 224507 (2002), 10.1103/PhysRevB.66.224507; J. M. Kosterlitz and N. Akino, Phys. Rev. Lett. 81, 4672 (1998), 10.1103/PhysRevLett.81.4672; Phys. Rev. Lett. 81, 4672 (1998), 10.1103/PhysRevLett.81.4672] that reveal that the energy to create a defect in a gauge or phase glass scales as Lθ with θ <0 for two dimensions, thereby implying a vanishing stiffness, we reexamine the relevance of these kinds of models to the Bose metal in light of the new experiments [N. P. Breznay and Kapitulnik (unpublished); Y. Wang, I. Tamir, D. Shahar, and N. P. Armitage, arXiv:1708.01908 [cond-mat.supr-con
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Chaotic and Bifurcating Nonlinear Systems Driven by Noise with Applications to Laser Dynamics
1988-12-30
W. o. leich and M. 0. Scully, Phys. Rev. A . 37, 3010 (1988) and ibid, 1261 (1988), and references therein. 14. A . K. Dhara and S. V . G. Menon, J...Fronzoni, F. Moss, R. Mannella and P. V . E. McClintock. Phys. Rev. A 36. 834 (1987) 35. L. Fronzoni, F. Moss and P. V . E. McClintock, Phys. Rev. A . 36...1492 (1987). 36. V . Altares and G. Nicolis, Phys. Rev. A 37. 3630 (1988) 37. R. Lefever and JI Win. Turner. Phys. Rev. Lett. 56, 1631 (1986) 38. K
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Chen Zhe; Bongiorni, Paul; Nath, Ravinder
2010-07-15
Purpose: Since its introduction in 2004, the model CS-1 Rev.1 {sup 131}Cs source has been used in many radiation therapy clinics for prostate brachytherapy. In 2006, this source model underwent a Rev.2 production revision. The aim of this work was to investigate the dosimetric influences of the Rev.2 production revision using high-resolution photon spectrometry. Methods: Three CS-1 Rev.1 and three CS-1 Rev.2 {sup 131}Cs sources were used in this study. The relative photon energy spectrum emitted by each source in the transverse bisector of the source was measured using a high-resolution germanium detector designed for low-energy photon spectrometry. Based onmore » the measured photon energy spectrum and the radioactivity distribution in the source, the dose-rate constant ({Lambda}) of each source was determined. The effects of the Rev.2 production revision were quantified by comparing the emitted photon energy spectra and the {Lambda} values determined for the sources manufactured before and after the production revision. Results: The relative photon energy spectrum originating from the principal emissions of {sup 131}Cs was found to be nearly identical before and after the Rev.2 revision. However, the portion of the spectrum originating from the production of fluorescent x rays in niobium, a trace element present in the source construction materials, was found to differ significantly between the Rev.1 and Rev.2 sources. The peak intensity of the Nb K{sub {alpha}} and Nb K{sub {beta}} fluorescent x rays from the Rev.2 source was approximately 35% of that from the Rev.1 source. Consequently, the nominal {Lambda} value of the Rev.2 source was found to be greater than that determined for the Rev.1 source by approximately 0.7%{+-}0.5%. Conclusions: A significant reduction (65%) in relative niobium fluorescent x-ray yield was observed in the Rev.2 {sup 131}Cs sources. The impact of this reduction on the dose-rate constant was found to be small, with a relative difference of less than 1%. This study demonstrates that photon spectrometry can be used as a sensitive and convenient tool for monitoring and for quantifying the dosimetric effects of brachytherapy source-production revisions. Because production revision can change both the geometry and the atomic composition of brachytherapy sources, its dosimetric impact should be carefully monitored and evaluated for each production revision.« less
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Z_c(3900): confronting theory and lattice simulations
NASA Astrophysics Data System (ADS)
Albaladejo, Miguel; Fernandez-Soler, Pedro; Nieves, Juan
2016-10-01
We consider a recent T-matrix analysis by Albaladejo et al. (Phys Lett B 755:337, 2016), which accounts for the J/ψ π and D^*bar{D} coupled-channels dynamics, and which successfully describes the experimental information concerning the recently discovered Z_c(3900)^± . Within such scheme, the data can be similarly well described in two different scenarios, where Z_c(3900) is either a resonance or a virtual state. To shed light into the nature of this state, we apply this formalism in a finite box with the aim of comparing with recent Lattice QCD (LQCD) simulations. We see that the energy levels obtained for both scenarios agree well with those obtained in the single-volume LQCD simulation reported in Prelovsek et al. (Phys Rev D 91:014504, 2015), thus making it difficult to disentangle the two possibilities. We also study the volume dependence of the energy levels obtained with our formalism and suggest that LQCD simulations performed at several volumes could help in discerning the actual nature of the intriguing Z_c(3900) state.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Morioka, Norimitsu, E-mail: mnori@hiroshima-u.ac.jp; Tomori, Mizuki; Zhang, Fang Fang
Under physiological conditions, astrocytes maintain homeostasis in the CNS. Following inflammation and injury to the CNS, however, activated astrocytes produce neurotoxic molecules such as cytokines and chemokines, amplifying the initial molecular-cellular events evoked by inflammation and injury. Nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammation- and metabolism-related gene transcription. The current study sought to elucidate a role of REV-ERBs in rat C6 astroglial cells on the expression of inflammatory molecules following stimulation with the neuroinflammatory cytokine tumor necrosis factor (TNF). Stimulation of C6 cells with TNF (10 ng/ml) significantly increased the mRNA expression of CCL2, interleukin-6more » (IL-6), inducible nitric oxide synthase (iNOS), and matrix metalloprotease (MMP)-9, but not fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (COX-2) and MMP-2. Treatment with either REV-ERB agonists GSK4112 or SR9009 significantly blocked TNF-induced upregulation of CCL2 mRNA and MMP-9 mRNA, but not IL-6 mRNA and iNOS mRNA expression. Furthermore, treatment with RGFP966, a selective histone deacetylase 3 (HDAC3) inhibitor, potently reversed the inhibitory effects of GSK4112 on TNF-induced expression of MMP-9 mRNA, but not CCL2 mRNA. Expression of Rev-erbs mRNA in C6 astroglial cells, primary cultured rat cortical and spinal astrocytes was confirmed by reverse transcription polymerase chain reaction. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 and CCL2 transcription, of astroglial REV-ERBs activation through HDAC3-dependent and HDAC3-independent mechanisms. - Highlights: • Rev-erbα mRNA and Rev-erbβ mRNA are expressed in C6 astroglial cells. • TNF increases the expression of CCL2, IL-6, MMP-9 and iNOS mRNA. • REV-ERB activation inhibits CCL2 mRNA and MMP-9 mRNA expression. • HDAC3 activity is involved in the inhibitory effect of REV-ERB on MMP-9 induction.« less
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A hydro-mechanical framework for early warning of rainfall-induced landslides (Invited)
NASA Astrophysics Data System (ADS)
Godt, J.; Lu, N.; Baum, R. L.
2013-12-01
Landslide early warning requires an estimate of the location, timing, and magnitude of initial movement, and the change in volume and momentum of material as it travels down a slope or channel. In many locations advance assessment of landslide location, volume, and momentum is possible, but prediction of landslide timing entails understanding the evolution of rainfall and soil-water conditions, and consequent effects on slope stability in real time. Existing schemes for landslide prediction generally rely on empirical relations between landslide occurrence and rainfall amount and duration, however, these relations do not account for temporally variable rainfall nor the variably saturated processes that control the hydro-mechanical response of hillside materials to rainfall. Although limited by the resolution and accuracy of rainfall forecasts and now-casts in complex terrain and by the inherent difficulty in adequately characterizing subsurface materials, physics-based models provide a general means to quantitatively link rainfall and landslide occurrence. To obtain quantitative estimates of landslide potential from physics-based models using observed or forecasted rainfall requires explicit consideration of the changes in effective stress that result from changes in soil moisture and pore-water pressures. The physics that control soil-water conditions are transient, nonlinear, hysteretic, and dependent on material composition and history. In order to examine the physical processes that control infiltration and effective stress in variably saturated materials, we present field and laboratory results describing intrinsic relations among soil water and mechanical properties of hillside materials. At the REV (representative elementary volume) scale, the interaction between pore fluids and solid grains can be effectively described by the relation between soil suction, soil water content, hydraulic conductivity, and suction stress. We show that these relations can be obtained independently from outflow, shear strength, and deformation tests for a wide range of earth materials. We then compare laboratory results with measurements of pore pressure and moisture content from landslide-prone settings and demonstrate that laboratory results obtained for hillside materials are representative of field conditions. These fundamental relations provide a basis to combine observed or forecasted rainfall with in-situ measurements of soil water conditions using hydro-mechanical models that simulate transient variably saturated flow and slope stability. We conclude that early warning using an approach in which in-situ observations are used to establish initial conditions for hydro-mechanical models is feasible in areas of high landslide risk where laboratory characterization of materials is practical and accurate rainfall information can be obtained. Analogous to weather and climate forecasting, such models could then be applied in an ensemble fashion to obtain quantitative estimates of landslide probability and error. Application to broader regions likely awaits breakthroughs in the development of remotely sensed proxies of soil properties and subsurface moisture conditions.
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Bontrager Yoder, Andrea B; Foecke, Leah L; Schoeller, Dale A
2015-10-01
To examine characteristics potentially associated with school lunch fruit and vegetable waste, both overall and pre/post implementation of the Healthy, Hunger-Free Kids Act. Multi-year (2010-2013) cross-sectional study using pre- and post-meal digital photographs of students' school lunch trays to estimate fruit and vegetable availability and consumption. Fruit and vegetable items were categorized for factors suspected to impact waste: prior farm to school years, placement (main menu, salad bar), procurement (local, conventional), preparation (cooked, raw) and meal component (entrée, side, topping). Analyses to assess within-category differences in waste volume were performed using a Tobit model. Wisconsin elementary schools participating in farm to school programmes, USA. Children in third to fifth grade. Many within-factor differences were detected overall and/or across time. Cooked fruits were wasted less than raw, while cooked vegetables were wasted more than raw. Where identified, locally sourced items were wasted more than conventionally sourced (+0·1 cups, P<0·0001) and salad bar items more than main menu items (+0·01 cups, P<0·0001). Increasing prior farm to school years decreased waste (-0·02 cups, P<0·0001). Items previously tried were wasted at the same volume whether reported as liked or not. New school lunch meal pattern requirement implementation did not uniformly impact fruit and vegetable waste across all categories and there was no change in waste for seven of fifteen assessed categories. Many factors impact elementary students' school lunch waste. These factors may be helpful for school food-service authorities to consider when planning school menus.
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Lee, Young-Sam; Gregory, Mark T.; Yang, Wei
2014-01-01
DNA polymerase ζ (Pol ζ) is a eukaryotic B-family DNA polymerase that specializes in translesion synthesis and is essential for normal embryogenesis. At a minimum, Pol ζ consists of a catalytic subunit Rev3 and an accessory subunit Rev7. Mammalian Rev3 contains >3,000 residues and is twice as large as the yeast homolog. To date, no vertebrate Pol ζ has been purified for biochemical characterization. Here we report purification of a series of human Rev3 deletion constructs expressed in HEK293 cells and identification of a minimally catalytically active human Pol ζ variant. With a tagged form of an active Pol ζ variant, we isolated two additional accessory subunits of human Pol ζ, PolD2 and PolD3. The purified four-subunit Pol ζ4 (Rev3–Rev7–PolD2–PolD3) is much more efficient and more processive at bypassing a 1,2-intrastrand d(GpG)-cisplatin cross-link than the two-subunit Pol ζ2 (Rev3–Rev7). We show that complete bypass of cisplatin lesions requires Pol η to insert dCTP opposite the 3′ guanine and Pol ζ4 to extend the primers. PMID:24449906
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Lee, Young-Sam; Gregory, Mark T; Yang, Wei
2014-02-25
DNA polymerase ζ (Pol ζ) is a eukaryotic B-family DNA polymerase that specializes in translesion synthesis and is essential for normal embryogenesis. At a minimum, Pol ζ consists of a catalytic subunit Rev3 and an accessory subunit Rev7. Mammalian Rev3 contains >3,000 residues and is twice as large as the yeast homolog. To date, no vertebrate Pol ζ has been purified for biochemical characterization. Here we report purification of a series of human Rev3 deletion constructs expressed in HEK293 cells and identification of a minimally catalytically active human Pol ζ variant. With a tagged form of an active Pol ζ variant, we isolated two additional accessory subunits of human Pol ζ, PolD2 and PolD3. The purified four-subunit Pol ζ4 (Rev3-Rev7-PolD2-PolD3) is much more efficient and more processive at bypassing a 1,2-intrastrand d(GpG)-cisplatin cross-link than the two-subunit Pol ζ2 (Rev3-Rev7). We show that complete bypass of cisplatin lesions requires Pol η to insert dCTP opposite the 3' guanine and Pol ζ4 to extend the primers.
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Biallelic inactivation of REV7 is associated with Fanconi anemia.
Bluteau, Dominique; Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d'Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D'Andrea, Alan D; Soulier, Jean
2016-09-01
Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient's cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.
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Biallelic inactivation of REV7 is associated with Fanconi anemia
Masliah-Planchon, Julien; Clairmont, Connor; Rousseau, Alix; Ceccaldi, Raphael; Dubois d’Enghien, Catherine; Bluteau, Olivier; Cuccuini, Wendy; Gachet, Stéphanie; Peffault de Latour, Régis; Leblanc, Thierry; Socié, Gérard; Baruchel, André; Stoppa-Lyonnet, Dominique; D’Andrea, Alan D.
2016-01-01
Fanconi anemia (FA) is a recessive genetic disease characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure (BMF), and a strong predisposition to cancer. Twenty FA genes have been identified, and the FANC proteins they encode cooperate in a common pathway that regulates DNA crosslink repair and replication fork stability. We identified a child with severe BMF who harbored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), which encodes the mutant REV7 protein REV7-V85E. Patient-derived cells demonstrated an extended FA phenotype, which included increased chromosome breaks and G2/M accumulation upon exposure to DNA crosslinking agents, γH2AX and 53BP1 foci accumulation, and enhanced p53/p21 activation relative to cells derived from healthy patients. Expression of WT REV7 restored normal cellular and functional phenotypes in the patient’s cells, and CRISPR/Cas9 inactivation of REV7 in a non-FA human cell line produced an FA phenotype. Finally, silencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA repair defect underlies the development of BMF in FA. Taken together, our genetic and functional analyses identified REV7 as a previously undescribed FA gene, which we term FANCV. PMID:27500492
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ERIC Educational Resources Information Center
Rosario, Jose; And Others
As part of a longitudinal study evaluating program effects, this report, the second in a series of six, describes the impact of Project Developmental Continuity (PDC) on the institutional policies and procedures of participating Head Start centers and elementary schools up to the time the evaluation study's cohort of children had completed grade…
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ERIC Educational Resources Information Center
Simmons, Eileen
2004-01-01
Eileen Simmons, a veteran teacher-consultant from the Oklahoma State University Writing Project, describes collaboration among writing project teacher-consultants and site-based teachers to plan professional development before, during, and after a summer writing camp for students at their school. This model, which has been adapted in a variety of…
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Career Education Activities for Subject Area Teachers. Grades 9 through 12.
ERIC Educational Resources Information Center
Finn, Peter; Lawson, Jane
Designed as a resource book which can be used to supplement the regular curriculum by integrating one or more career education activities into regularly taught courses, this volume for grades 9 through 12 is one of a series of three manuals, one each for the elementary (grades 1-6), junior high (grades 6-9), and senior high (grades 9-12) levels.…
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Career Education Activities for Subject Area Teachers. Grades 1 through 6.
ERIC Educational Resources Information Center
Lawson, Jane; Finn, Peter
Designed as a resource book which can be used to supplement the regular curriculum by integrating one or more career education activities into regularly taught courses, this volume for grades 1 through 6 is one of a series of three manuals, one each for the elementary (grades 1-6), junior high (grades 6-9), and senior high (grades 9-12) levels. It…
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Career Education Activities for Subject Area Teachers. Grades 6 through 9.
ERIC Educational Resources Information Center
Finn, Peter; Lawson, Jane
Designed as a resource book which can be used to supplement the regular curriculum by integrating one or more career education activities into regularly taught courses, this volume for grades 6 through 9 is one of a series of three manuals, one each for the elementary (grades 1-6), junior high (grades 6-9), and senior high (grades 9-l2) levels. It…
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ERIC Educational Resources Information Center
Johnson, Shaun P.
2008-01-01
Current statistics show that roughly one quarter of all classroom teachers are male: this proportion sinks to approximately ten percent in the elementary grades. A scarcity of men in teaching is not a new phenomenon and has remained relatively constant through more than a century of various educational reforms. This brief discusses the historical…
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ERIC Educational Resources Information Center
Leeds Education Authority (England). Mathematics Curriculum Study Group.
This is one of a series of monographs developed by teachers in elementary schools near Leeds, England. This document focuses on early instruction of number concepts. It is considered essential that these ideas be presented first in concrete form. The working group attempted to provide a detailed progression in the developmental stages leading to…
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ERIC Educational Resources Information Center
Herman, Rebecca; Gates, Susan M.; Chavez-Herrerias, Emilio R.; Harris, Mark
2016-01-01
The reauthorization of the U.S. Elementary and Secondary Education Act, referred to as the Every Student Succeeds Act (ESSA), emphasizes evidence-based initiatives while providing new flexibilities to states and districts with regard to the use of federal funds, including funds to promote effective school leadership. This report describes the…
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ERIC Educational Resources Information Center
Texas Education Agency, Austin.
Twenty-three papers on the use of higher order thinking approaches to improve basic skills education are presented. The key note article is (1) "A Case for Higher Order Thinking" (G. Garcia, Jr.). Under the heading "English Language Arts" are: (2) "Developing an Elementary Writing Program" (K. Contreras); (3)…
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ERIC Educational Resources Information Center
Chambers, Jay G.; Lam, Irene; Mahitivanichcha, Kanya; Esra, Phil; Shambaugh, Larisa; Stullich, Stephanie
2009-01-01
Achieving the goals of federal education legislation depends on how federal funds are distributed and used. Since the enactment of the Elementary and Secondary Education Act (ESEA) in 1965, various federal programs have been created to support educational improvement and target additional resources to meet the educational needs of children who are…
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Installation Restoration Program, Phase II (Stage 2-1). Volume 2.
1985-05-01
Worthington OH PAGES: 89 SOURCE: Radian Library COMMENTS: General manual for well drilling, sample collection . Includes good elementary background. FIRST... Collected from the Base Industrial and Domestic Waste Water Treatment Plants and Field * Sampling Data PAGES: 75 p. SOURCE: Capt. Mario Ierarti * COMMENTS...Analytical results for samples collected from the * base industrial and domestic wastewater treatment plants have been included. RADIAN FIRST AUTHOR
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ERIC Educational Resources Information Center
Franklin, Marian Pope, Comp.
Over 400 journal articles, case studies, research reports, dissertations, and position papers are briefly described in a series of eight selected bibliographies related to school organization. The eight specific areas treated in the volume and the number of items listed for each include: nongraded elementary school organization, 96; nongraded…
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ERIC Educational Resources Information Center
Melaragno, Ralph J.; And Others
Intended to provide a comprehensive view of parental involvement in school districts receiving federal education funds, this study collected data on four federal programs in 57 projects across the country. Titles I and VII of the Elementary Secondary Education Act, the Emergency School Aid Act, and Follow Through were examined. The entire study is…
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ERIC Educational Resources Information Center
Clarke School for the Deaf, Northampton, MA.
Papers from five plenary sessions and a number of sectional meetings consider oral education of the deaf. Elementary and secondary deaf education programs are discussed with reference to teaching the multiply handicapped, curriculum development, programed instruction, and teaching methods and materials. The following are also treated: the subject…
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ERIC Educational Resources Information Center
Keesling, J. Ward; And Others
This study (one portion of a larger study) was designed to determine whether Elementary and Secondary Education Act Title I programs in State institutions for neglected or delinquent youth are effective in improving students' basic skills and attitudes and to determine which components of educational programs and characteristics of institutions…
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Quantum-Critical Dynamics of the Skyrmion Lattice.
NASA Astrophysics Data System (ADS)
Green, Andrew G.
2002-03-01
Slightly away from exact filling of the lowest Landau level, the quantum Hall ferromagnet contains a finite density of magnetic vortices or Skyrmions[1,2]. These Skyrmions are expected to form a square lattice[3], the low energy excitations of which (translation/phonon modes and rotation/breathing modes) lead to dramatically enhanced nuclear relaxation[4,5]. Upon changing the filling fraction, the rotational modes undergo a quantum phase transition where zero-point fluctuations destroy the orientational order of the Skyrmions[4,6]. I will discuss the effect of this quantum critical point upon nuclear spin relaxation[7]. [1]S. L. Sondhi et al., Phys. Rev. B47, 16419 (1993). [2]S. E. Barrett et al., Phys. Rev. Lett. 74, 5112 (1995), A. Schmeller et al., Phys. Rev. Lett. 75, 4290 (1995). [3]L. Brey et al, Phys. Rev. Lett. 75, 2562 (1995). [4]R. Côté et al., Phys. Rev. Lett. 78, 4825 (1997). [5]R. Tycko et al., Science 268, 1460 (1995). [6]Yu V. Nazarov and A. V. Khaetskii, Phys. Rev. Lett. 80, 576 (1998). [7]A. G. Green, Phys. Rev. B61, R16 299 (2000).
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Reply to "Comment on `Particle path through a nested Mach-Zehnder interferometer' "
NASA Astrophysics Data System (ADS)
Griffiths, Robert B.
2018-02-01
While much of the technical analysis in the preceding Comment is correct, in the end it confirms the conclusion reached in my previous work [Phys. Rev. A 94, 032115 (2016), 10.1103/PhysRevA.94.032115]: A consistent histories analysis provides no support for the claim of counterfactual quantum communication put forward by Salih et al. [Phys. Rev. Lett. 110, 170502 (2013), 10.1103/PhysRevLett.110.170502].
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α-decay systematics for superheavy elements
NASA Astrophysics Data System (ADS)
Duarte, S. B.; Teruya, N.
2012-01-01
In this Brief Report we extend the α-decay half-life calculation to the superheavy emitter region to verify whether these nuclei satisfy the recently observed systematics [D. N. Poenaru , Phys. Rev. CPRVCAN0556-281310.1103/PhysRevC.83.014601 83, 014601 (2011);C. Qi , Phys. Rev. CPRVCAN0556-281310.1103/PhysRevC.80.044326 80, 044326 (2009)]. To establish the systematics, we have used the α-cluster potential description, which was originally developed to study α decay in connection with nuclear energy level structure [B. Buck , Phys. Rev. CPRVCAN0556-281310.1103/PhysRevC.51.559 51, 559 (1995)]. The quantum-mechanical tunneling calculation has been employed to obtain the half-lives, showing that with this treatment the systematics are well reproduced in the region of heavy nuclei. Finally, the half-life calculation has been extended to the superheavy emitters to verify whether the systematics can still be observed.
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Super-exchange in transition-metal oxides
NASA Astrophysics Data System (ADS)
Harrison, Walter
2007-03-01
Using contemporary tight-binding theory and parameters[1]. Anderson's perturbation approach [2] gives a qualitatively correct energy difference (a factor 2.3 too high) between ferromagnetic and antiferromagnetic configurations for MnO, It corresponds to a Heisenberg model with J2/J1= 11/7. Perturbation theory fails as the energy denominator gets smaller for FeO and CoO, and changes sign for NiO. Use of the special- points method to treat exchange-split bands gives smaller values not well characterized by a J1 and J2. Carrying it out self-consistently reorders the NiO levels and leads to still smaller energy differences near experiment for all four oxides, as estimated from the experimental N'eel temperature TN , The theory predicts a variation with pressure corresponding to (d/ TN)TN/d = -12.2 for MnO , near experiment, dropping to -9.1 for NiO. The theory is applicable also to the paramagnetic susceptibility. [1] Walter A. Harrison, Elementary Electronic Structure, World Scientific (Singapore, 1999), revised edition (2004). [2] P. W. Anderson, Phys. Rev. 115, 2 (1959).
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Latha, K. V. P.; Chaudhuri, R. K.; Das, B. P.
2007-12-15
The electric quadrupole moment for the 5d {sup 2}D{sub 3/2} state of {sup 171}Yb{sup +}, has been calculated using the relativistic coupled-cluster method. Earlier a similar calculation was performed for the 4d {sup 2}D{sub 5/2} state of {sup 88}Sr{sup +} which is the most accurate determination to date [Sur et al., Phys. Rev. Lett. 96, 193001 (2006)]. The present calculation of the electric quadrupole moment of {sup 171}Yb{sup +} yielded a value 2.157ea{sub 0}{sup 2} where the experimental value is 2.08(11)ea{sub 0}{sup 2}; a{sub 0} is the Bohr radius and e the elementary charge. We discuss in this paper ourmore » results for {sup 171}Yb{sup +} in detail and highlight the dominant correlation effects present. We have presented the effect of inner core excitations and their contribution to the electric quadrupole moment, which is a property sensitive to regions away from the nucleus.« less
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Boehm, Elizabeth M.; Powers, Kyle T.; Kondratick, Christine M.; Spies, Maria; Houtman, Jon C. D.; Washington, M. Todd
2016-01-01
Y-family DNA polymerases, such as polymerase η, polymerase ι, and polymerase κ, catalyze the bypass of DNA damage during translesion synthesis. These enzymes are recruited to sites of DNA damage by interacting with the essential replication accessory protein proliferating cell nuclear antigen (PCNA) and the scaffold protein Rev1. In most Y-family polymerases, these interactions are mediated by one or more conserved PCNA-interacting protein (PIP) motifs that bind in a hydrophobic pocket on the front side of PCNA as well as by conserved Rev1-interacting region (RIR) motifs that bind in a hydrophobic pocket on the C-terminal domain of Rev1. Yeast polymerase η, a prototypical translesion synthesis polymerase, binds both PCNA and Rev1. It possesses a single PIP motif but not an RIR motif. Here we show that the PIP motif of yeast polymerase η mediates its interactions both with PCNA and with Rev1. Moreover, the PIP motif of polymerase η binds in the hydrophobic pocket on the Rev1 C-terminal domain. We also show that the RIR motif of human polymerase κ and the PIP motif of yeast Msh6 bind both PCNA and Rev1. Overall, these findings demonstrate that PIP motifs and RIR motifs have overlapping specificities and can interact with both PCNA and Rev1 in structurally similar ways. These findings also suggest that PIP motifs are a more versatile protein interaction motif than previously believed. PMID:26903512
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Song, Yue; Xin, Xing; Xia, Zhijun; Zhai, Xingyue; Shen, Keng
2014-07-01
The objective of our study was to construct recombinant adenovirus (rAd) AdHTVP2G5-rev-casp3, which expresses autocatalytic caspase-3 driven by human telomerase reverse transcriptase promoter (hTERTp) with a two-step transcription amplification (TSTA) system and investigate its antitumor effects on ovarian cancer in vitro and in vivo. Fluorescent detection was used to detect EGFP expression in various cells. Cell viabilities were determined using the Cell Counting Kit-8 and flow cytometry. RT-PCR and immunoblotting assays were used to detect cellular apoptotic activities. Tumor growth and survival of tumor-bearing mice were studied. The hTERTp-TSTA system showed the strongest activity in hTERT-positive cancer cells when compared with hTERTp and cytomeglovirus promoter (CMVp). In contrast, it showed no activity in hTERT‑negative HUVECs. AdHTVP2G5‑rev-casp3 markedly suppressed the survival of AO cells in a dose-dependent modality with a viability rate of 17.8 ± 3.5% at an MOI of 70, which was significantly lower than that by AdHT-rev-casp3 and Ad-rev-casp3 (rAds which express rev-caspase-3 driven by hTERTp and CMVp, respectively). In contrast, AdHTVP2G5‑rev-casp3 induced little HUVEC death with a viability rate of 92.7 ± 5.2% at the same MOI. Additionally, AdHTVP2G5-rev-casp3 (MOI=70) caused significant apoptosis in AO cells with an apoptotic rate of 42%. The tumor growth suppression rate of AdHTVP2G5-rev-casp3 was 81.52%, significantly higher than that of AdHT-rev-casp3 (54.94%) or Ad-rev-casp3 (21.35%). AdHTVP2G5-rev-casp3 significantly improved the survival of tumor-bearing mice with little liver damage, with a mean survival of 258 ± 28 days. These results showed that AdHTVP2G5-rev-casp3 caused effective apoptosis with significant tumor selectivity, strongly suppressed tumor growth and improved mouse survival with little liver toxicity. It can be a potent therapeutic agent for tumor targeted treatment of ovarian cancer.
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1990-05-01
Mahan , W. Raith, and B. Reihl, Phys. Rev. BI8, 2256 (1978). 6. R. Meservey, P. M. Tedrow, and J. S . Moodera, J. Mag. and Mag. Mat. 35, 1 (1983). 7. J...j L. X1PGr DATI 1. WIORT’ TYPE A10 DATES COjgITal 02QR -UMay 89-01 May 90 Dr Jan B BalanceAFOSR-89-0388 T. PjUQMiM ORGAMLAION NAME( S ) AND ADOXESS(I5J...L. FIZZ=g~ CGAIZAflON Materials Researc ’ SocietyA~ NmI 49800 14cKnight Road, Suite 327 AFOSR-TI ( 4 6 Pittsburgh Pa 15237-6005 S
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Reply to "Comment on `Protecting bipartite entanglement by quantum interferences' "
NASA Astrophysics Data System (ADS)
Das, Sumanta; Agarwal, G. S.
2018-03-01
In a recent Comment Nair and Arun, Phys. Rev. A 97, 036301 (2018), 10.1103/PhysRevA.97.036301, it was concluded that the two-qubit entanglement protection reported in our work [Das and Agarwal, Phys. Rev. A 81, 052341 (2010), 10.1103/PhysRevA.81.052341] is erroneous. While we acknowledge the error in analytical results on concurrence when dipole matrix elements were unequal, the essential conclusions on entanglement protection are not affected.
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The propagator of stochastic electrodynamics
NASA Astrophysics Data System (ADS)
Cavalleri, G.
1981-01-01
The "elementary propagator" for the position of a free charged particle subject to the zero-point electromagnetic field with Lorentz-invariant spectral density ~ω3 is obtained. The nonstationary process for the position is solved by the stationary process for the acceleration. The dispersion of the position elementary propagator is compared with that of quantum electrodynamics. Finally, the evolution of the probability density is obtained starting from an initial distribution confined in a small volume and with a Gaussian distribution in the velocities. The resulting probability density for the position turns out to be equal, to within radiative corrections, to ψψ* where ψ is the Kennard wave packet. If the radiative corrections are retained, the present result is new since the corresponding expression in quantum electrodynamics has not yet been found. Besides preceding quantum electrodynamics for this problem, no renormalization is required in stochastic electrodynamics.
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Altered Sleep Homeostasis in Rev-erbα Knockout Mice
Mang, Géraldine M.; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A.; Albrecht, Urs; Franken, Paul
2016-01-01
Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequences of a loss of REV-ERBα on the homeostatic regulation of sleep. Methods: EEG/EMG signals were recorded in Rev-erbα knockout (KO) mice and their wild type (WT) littermates during baseline, sleep deprivation, and recovery. Cortical gene expression measurements after sleep deprivation were contrasted to baseline. Results: Although baseline sleep/wake duration was remarkably similar, KO mice showed an advance of the sleep/wake distribution relative to the light-dark cycle. After sleep onset in baseline and after sleep deprivation, both EEG delta power (1–4 Hz) and sleep consolidation were reduced in KO mice indicating a slower increase of homeostatic sleep need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to sleep onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM sleep. Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain. Conclusions: Our results add further proof to the notion that clock genes are involved in sleep homeostasis. Because accumulating evidence directly links REV-ERBα to dopamine signaling the altered homeostatic regulation of sleep reported here are discussed in that context. Citation: Mang GM, La Spada F, Emmenegger Y, Chappuis S, Ripperger JA, Albrecht U, Franken P. Altered sleep homeostasis in Rev-erbα knockout mice. SLEEP 2016;39(3):589–601. PMID:26564124
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HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment
Taniguchi, Ichiro; Mabuchi, Naoto; Ohno, Mutsuhito
2014-01-01
Nuclear RNA export pathways in eukaryotes are often linked to the fate of a given RNA. Therefore, the choice of export pathway should be well-controlled to avoid an unfavorable effect on gene expression. Although some RNAs could be exported by more than one pathway, little is known about how the choice is regulated. This issue is highlighted when the human immunodeficiency virus type 1 (HIV-1) Rev protein induces the export of singly spliced and unspliced HIV-1 transcripts. How these RNAs are exported is not well understood because such transcripts should have the possibility of utilizing CRM1-dependent export via Rev or cellular TAP/NXF1-dependent export via the transcription/export (TREX) complex, or both. Here we found that Rev suppressed TAP/NXF1-dependent export of model RNA substrates that recapitulated viral transcripts. In this effect, Rev interacted with the cap-binding complex and inhibited the recruitment of the TREX complex. Thus, Rev controls the identity of the factor occupying the cap-proximal region that determines the RNA export pathway. This ribonucleoprotein remodeling activity of Rev may favor viral gene expression. PMID:24753416
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Magnetic and structural X-ray dichroïsms of metallic multilayers
NASA Astrophysics Data System (ADS)
Pizzini, Stefania; Fontaine, A.; Baudelet, F.; Minr, S.; Giorgetti, C.; Dartyge, E.; Bobo, J. F.; Piecuch, M.
1995-05-01
Fe/Cu and Co/Cu multilayers are intensively studied because of their exceptional magnetic properties, i.e., their giant magnetoresistance and the oscillations of the magnetic coupling between magnetic layers as a function of the thickness of the copper spacer [S.S. Parkin et al., Phys. Rev. Lett. 66 (1991) 2152; F. Petroff et al., Phys. Rev. B 44 (1991) 5355]. Spectroscopic approaches to the understanding of the coupling of ferromagnetic layers through a noble metal layer have been recently introduced, in particular spin-resolved photoemission [N.B. Brookes et al., Phys. Rev. Lett. 67 (1991) 354; C. Carbone et al., PRL 71 (1993) 2805] inverse photoemission [J.E. Ortega et al., Phys. Rev. Lett. 69 (1992) 844; Phys. Rev. B 47 (1993) 1540] and magnetic circular dichroism [S. Pizzini et al., MRS Symp. Proc., vol. 313 (1993); M.G. Samant et al. Phys. Rev. Lett. 72 (1994) 2152; S. Pizzini et al., Phys. Rev. Lett. 74 (1995) 1470]. X-ray absorption spectroscopy appears to be effective both for determination of the local structure, specific to the bidimensionality of the system but also for the electron symmetry-dependent evaluation of the spin polarisation of the noble metal as well as the magnetic element.
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Huang, Feng; Zhang, Junsong; Zhang, Yijun; Geng, Guannan; Liang, Juanran; Li, Yingniang; Chen, Jingliang; Liu, Chao; Zhang, Hui
2015-12-01
Human immunodeficiency virus type 1 (HIV-1) exploits multiple host factors during its replication. The REV/RRE-dependent nuclear export of unspliced/partially spliced viral transcripts needs the assistance of host proteins. Recent studies have shown that MOV10 overexpression inhibited HIV-1 replication at various steps. However, the endogenous MOV10 was required in certain step(s) of HIV-1 replication. In this report, we found that MOV10 potently enhances the nuclear export of viral mRNAs and subsequently increases the expression of Gag protein and other late products through affecting the Rev/RRE axis. The co-immunoprecipitation analysis indicated that MOV10 interacts with Rev in an RNA-independent manner. The DEAG-box of MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export and the DEAG-box mutant showed a dominant-negative activity. Our data propose that HIV-1 utilizes the anti-viral factor MOV10 to function as a co-factor of Rev and demonstrate the complicated effects of MOV10 on HIV-1 life cycle. Copyright © 2015 Elsevier Inc. All rights reserved.
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NASA Astrophysics Data System (ADS)
Xu, Jie; Wu, Tao; Peng, Chuang; Adegbite, Stephen
2017-09-01
The geometric Plateau border model for closed cell polyurethane foam was developed based on volume integrations of approximated 3D four-cusp hypocycloid structure. The tetrahedral structure of convex struts was orthogonally projected into 2D three-cusp deltoid with three central cylinders. The idealized single unit strut was modeled by superposition. The volume of each component was calculated by geometric analyses. The strut solid fraction f s and foam porosity coefficient δ were calculated based on representative elementary volume of Kelvin and Weaire-Phelan structures. The specific surface area Sv derived respectively from packing structures and deltoid approximation model were put into contrast against strut dimensional ratio ɛ. The characteristic foam parameters obtained from this semi-empirical model were further employed to predict foam thermal conductivity.
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Biological responses of beef steers to steroidal implants and zilpaterol hydrochloride.
Parr, S L; Brown, T R; Ribeiro, F R B; Chung, K Y; Hutcheson, J P; Blackwell, B R; Smith, P N; Johnson, B J
2014-08-01
British × Continental steers (n = 168; 7 pens/treatment; initial BW = 362 kg) were used to evaluate the effect of dose/payout pattern of trenbolone acetate (TBA) and estradiol-17β (E2) and feeding of zilpaterol hydrochloride (ZH) on serum urea-N (SUN), NEFA, IGF-I, and E2 concentrations and LM mRNA expression of the estrogen (ER), androgen (ANR), IGF-I (IGF-IR), β1-adrenergic (β1-AR), and β2-adrenergic (β2-AR) receptors and IGF-I. A randomized complete block design was used with a 3 × 2 factorial arrangement of treatments. Main effects were implant (no implant [NI], Revalor-S [REV-S; 120 mg TBA + 24 mg E2], and Revalor-XS [REV-X; 200 mg TBA + 40 mg E2]) and ZH (0 or 8.3 mg/kg of DM for 20 d with a 3-d withdrawal). Steers were fed for 153 or 174 d. Blood was collected (2 steers/pen) at d -1, 2, 6, 13, 27, 55, 83, 111, and 131 relative to implanting; LM biopsies (1 steer/pen) were collected at d -1, 27, 55, and 111. Blood and LM samples were collected at d -1, 11, and 19 relative to ZH feeding. A greater dose of TBA + E2 in combination with ZH increased ADG and HCW in an additive manner, suggesting a different mechanism of action for ZH and steroidal implants. Implanting decreased (P < 0.05) SUN from d 2 through 131. Feeding ZH decreased (P < 0.05) SUN. Serum NEFA concentrations were not affected by implants (P = 0.44). There was a day × ZH interaction (P = 0.06) for NEFA; ZH steers had increased (P < 0.01) NEFA concentrations at d 11 of ZH feeding. Serum E2 was greater (P < 0.05) for implanted steers by d 27. Serum trenbolone-17β was greater (P < 0.05) for implanted steers by d 2 followed by a typical biphasic release rate, with a secondary peak at d 111 for REV-X (P < 0.05) implanted steers. Implanting did not affect mRNA expression of the ANR or ER, but the IGF-IR and the β1-AR and β2-AR were less (P < 0.05) for REV-S than NI at d 55 and β2-AR mRNA was less (P < 0.05) for REV-S than for REV-X. Expression of the IGF-IR and the β1-AR at d 111 was greater (P< 0.05) for REV-X than for REV-S and NI at d 111, and the β2-AR was less (P< 0.05) for REV-S than for REV-X. Feeding ZH did not affect mRNA expression of the β1-AR and β2-AR. Both implanting and feeding ZH decreased SUN, but a greater dose of TBA + E2 did not result in further decreases. In addition, feeding ZH increased serum NEFA concentrations. Metabolic changes resulting from implanting and feeding ZH may aid in explaining steer performance and carcass responses to these growth promotants.
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Low Temperature Power Coating (LTPC) Phase 2 Laboratory Test Plan and Procedures for PACAF (Rev D)
2018-03-20
Δa*, LTPC Phase II Laboratory Test Plan and Procedures Rev D (CDRL A004) BATTELLE | 20 March 2018 | 6 Δb* and ΔE will be calculated post ...BATTELLE | CONTRACT NUMBER: FA8532-17-C-0008 (CDRL A004) LTPC Phase II Laboratory Test Plan and Procedures (Rev D) Prepared by... Test Plan and Procedures Rev D (CDRL A004) BATTELLE | 20 March 2018 | i List of Acronyms AGE Aircraft Ground Equipment ASTM American
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Multiplicity-dependent and nonbinomial efficiency corrections for particle number cumulants
NASA Astrophysics Data System (ADS)
Bzdak, Adam; Holzmann, Romain; Koch, Volker
2016-12-01
In this article we extend previous work on efficiency corrections for cumulant measurements [Bzdak and Koch, Phys. Rev. C 86, 044904 (2012), 10.1103/PhysRevC.86.044904; Phys. Rev. C 91, 027901 (2015), 10.1103/PhysRevC.91.027901]. We will discuss the limitations of the methods presented in these papers. Specifically we will consider multiplicity dependent efficiencies as well as nonbinomial efficiency distributions. We will discuss the most simple and straightforward methods to implement those corrections.
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Aging and Rejuvenation with Fractional Derivatives
2004-09-10
Chechkin , J. Klafter, V . Yu . Gonchar , R. Metzler, and L. V . Tanatarov, Phys. Rev. E 67, 010102(R) (2003). [12] I. M. Sokolov and R. Metzler, Phys. Rev. E 67...051106 (2001). [7] A . V . Chechkin , R. Gorenflo, and I. M. Sokolov, Phys. Rev. E 66, 046129 (2002). [8] J. Bisquert, Phys. Rev. Lett. 91, 010602 (2003...9] R. Metzler and J. Klafter, J. Phys. Chem. B 104 3851 (2000). [10] E. Barkai and R. J. Silbey, J. Phys. Chem. B 104 3866 (2000).
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Reply to "Comment on `Troublesome aspects of the Renyi-MaxEnt treatment' "
NASA Astrophysics Data System (ADS)
Plastino, A.; Rocca, M. C.; Pennini, F.
2017-11-01
This Reply is intended as a refutation of the preceding Comment [Oikonomou and Bagci, Phys. Rev. E 96, 056101 (2017), 10.1103/PhysRevE.96.056101] on our paper [Plastino et al., Phys. Rev. E 94, 012145 (2016)., 10.1103/PhysRevE.94.012145]. We show that the Tsallis probability distribution of our paper does not coincide with the Tsallis distribution studied by Oikonomou and Bagci. Consequently, their findings do not apply to our paper.
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Reply to "Comment on 'Troublesome aspects of the Renyi-MaxEnt treatment' ".
Plastino, A; Rocca, M C; Pennini, F
2017-11-01
This Reply is intended as a refutation of the preceding Comment [Oikonomou and Bagci, Phys. Rev. E 96, 056101 (2017)10.1103/PhysRevE.96.056101] on our paper [Plastino et al., Phys. Rev. E 94, 012145 (2016).1539-375510.1103/PhysRevE.94.012145]. We show that the Tsallis probability distribution of our paper does not coincide with the Tsallis distribution studied by Oikonomou and Bagci. Consequently, their findings do not apply to our paper.
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Optimized Chemical Probes for REV-ERBα
Trump, Ryan P.; Bresciani, Stefano; Cooper, Anthony W. J.; Tellam, James P.; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A.; Kashatus, Jennifer A.; Dawson, Helen C.; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N.; Willson, Timothy M.; Tomkinson, Nicholas C. O.
2015-01-01
REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability. Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either IV or oral dosing. PMID:23656296
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Multiplicity-dependent and nonbinomial efficiency corrections for particle number cumulants
Bzdak, Adam; Holzmann, Romain; Koch, Volker
2016-12-19
Here, we extend previous work on efficiency corrections for cumulant measurements [Bzdak and Koch, Phys. Rev. C 86, 044904 (2012)PRVCAN0556-281310.1103/PhysRevC.86.044904; Phys. Rev. C 91, 027901 (2015)PRVCAN0556-281310.1103/PhysRevC.91.027901]. We will then discuss the limitations of the methods presented in these papers. Specifically we will consider multiplicity dependent efficiencies as well as nonbinomial efficiency distributions. We will discuss the most simple and straightforward methods to implement those corrections.
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ERIC Educational Resources Information Center
Thompson, Mary P.; And Others
This is the third volume in a series of texts in a conversational Spanish course for elementary school children. Nine basic units present introductory linguistic patterns and cultural insights into the lives of the Spanish people. They include: (1) Review Unit 1, ("Cristobal Colon"), (2) Review Unit 2, (3) "Un Accidente,""La Navidad," and…
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ERIC Educational Resources Information Center
Knapp, Michael S., Ed.; Shields, Patrick M., Ed.
This document comprises nine commissioned papers and four literature review chapters that are part of the first report of the Study of Academic Instruction for Disadvantaged Students, a 3-year investigation of curriculum and instruction in elementary schools serving high concentrations of poor children. (A summary of this report is presented in…
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ERIC Educational Resources Information Center
Schlenker, Richard M.; Dillon, Timothy
This document contains lab activities, problem sets, and a tape script to be accompanied by a slide show. The minicourse covers the following topics of general chemistry: kinetic-molecular theory, the Bohr atom, acids, bases, and salts, the periodic table, bonding, chemical equations, the metric system, computation of density, mass, and volume,…
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1980-12-01
data un Israeli experience with troops lacking literacy , elementary education, and/or psychomotor skills required for many current military occupations...overview of the relationship of cognitive skills to training and performance, with special reference to man-machine systems, (,nd the problems that...effective use of troops with low educational levels and psychomotor skills . Some IDF reports on these subjects are known to exist, and some interviews
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ERIC Educational Resources Information Center
Carter, George E., Ed.; Parker, James R., Ed.
The articles in this document emphasize the positive, unique aspects of Afro-American folklore. Etta Moten Barnett concentrates on the changes in African music in response to the new geographical and cultural influences in America. Frank Suggs, Jr. describes a strategy for introducing black folklore and black music into the elementary school in an…
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Vieira, Elaine; Marroquí, Laura; Figueroa, Ana Lucia C.; Merino, Beatriz; Fernandez-Ruiz, Rebeca; Nadal, Angel; Burris, Thomas P.; Gomis, Ramon; Quesada, Ivan
2013-01-01
Disruption of pancreatic clock genes impairs pancreatic beta-cell function, leading to the onset of diabetes. Despite the importance of pancreatic alpha-cells in the regulation of glucose homeostasis and in diabetes pathophysiology, nothing is known about the role of clock genes in these cells. Here, we identify the clock gene Rev-erb alpha as a new intracellular regulator of glucagon secretion. Rev-erb alpha down-regulation by siRNA (60–70% inhibition) in alphaTC1-9 cells inhibited low-glucose induced glucagon secretion (p<0.05) and led to a decrease in key genes of the exocytotic machinery. The Rev-erb alpha agonist GSK4112 increased glucagon secretion (1.6 fold) and intracellular calcium signals in alphaTC1-9 cells and mouse primary alpha-cells, whereas the Rev-erb alpha antagonist SR8278 produced the opposite effect. At 0.5 mM glucose, alphaTC1-9 cells exhibited intrinsic circadian Rev-erb alpha expression oscillations that were inhibited by 11 mM glucose. In mouse primary alpha-cells, glucose induced similar effects (p<0.001). High glucose inhibited key genes controlled by AMPK such as Nampt, Sirt1 and PGC-1 alpha in alphaTC1-9 cells (p<0.05). AMPK activation by metformin completely reversed the inhibitory effect of glucose on Nampt-Sirt1-PGC-1 alpha and Rev-erb alpha. Nampt inhibition decreased Sirt1, PGC-1 alpha and Rev-erb alpha mRNA expression (p<0.01) and glucagon release (p<0.05). These findings identify Rev-erb alpha as a new intracellular regulator of glucagon secretion via AMPK/Nampt/Sirt1 pathway. PMID:23936124
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Altered Sleep Homeostasis in Rev-erbα Knockout Mice.
Mang, Géraldine M; La Spada, Francesco; Emmenegger, Yann; Chappuis, Sylvie; Ripperger, Jürgen A; Albrecht, Urs; Franken, Paul
2016-03-01
The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes. Recently, REV-ERBα's involvement in learning, neurogenesis, mood, and dopamine turnover was demonstrated suggesting a specific role in central nervous system functioning. We have previously shown that the brain expression of several core clock genes, including Rev-erbα, is modulated by sleep loss. We here test the consequences of a loss of REV-ERBα on the homeostatic regulation of sleep. EEG/EMG signals were recorded in Rev-erbα knockout (KO) mice and their wild type (WT) littermates during baseline, sleep deprivation, and recovery. Cortical gene expression measurements after sleep deprivation were contrasted to baseline. Although baseline sleep/wake duration was remarkably similar, KO mice showed an advance of the sleep/wake distribution relative to the light-dark cycle. After sleep onset in baseline and after sleep deprivation, both EEG delta power (1-4 Hz) and sleep consolidation were reduced in KO mice indicating a slower increase of homeostatic sleep need during wakefulness. This slower increase might relate to the smaller increase in theta and gamma power observed in the waking EEG prior to sleep onset under both conditions. Indeed, the increased theta activity during wakefulness predicted delta power in subsequent NREM sleep. Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain. Our results add further proof to the notion that clock genes are involved in sleep homeostasis. Because accumulating evidence directly links REV-ERBα to dopamine signaling the altered homeostatic regulation of sleep reported here are discussed in that context. © 2016 Associated Professional Sleep Societies, LLC.
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Kan, Hirohito; Kasai, Harumasa; Arai, Nobuyuki; Kunitomo, Hiroshi; Hirose, Yasujiro; Shibamoto, Yuta
2016-09-01
An effective background field removal technique is desired for more accurate quantitative susceptibility mapping (QSM) prior to dipole inversion. The aim of this study was to evaluate the accuracy of regularization enabled sophisticated harmonic artifact reduction for phase data with varying spherical kernel sizes (REV-SHARP) method using a three-dimensional head phantom and human brain data. The proposed REV-SHARP method used the spherical mean value operation and Tikhonov regularization in the deconvolution process, with varying 2-14mm kernel sizes. The kernel sizes were gradually reduced, similar to the SHARP with varying spherical kernel (VSHARP) method. We determined the relative errors and relationships between the true local field and estimated local field in REV-SHARP, VSHARP, projection onto dipole fields (PDF), and regularization enabled SHARP (RESHARP). Human experiment was also conducted using REV-SHARP, VSHARP, PDF, and RESHARP. The relative errors in the numerical phantom study were 0.386, 0.448, 0.838, and 0.452 for REV-SHARP, VSHARP, PDF, and RESHARP. REV-SHARP result exhibited the highest correlation between the true local field and estimated local field. The linear regression slopes were 1.005, 1.124, 0.988, and 0.536 for REV-SHARP, VSHARP, PDF, and RESHARP in regions of interest on the three-dimensional head phantom. In human experiments, no obvious errors due to artifacts were present in REV-SHARP. The proposed REV-SHARP is a new method combined with variable spherical kernel size and Tikhonov regularization. This technique might make it possible to be more accurate backgroud field removal and help to achive better accuracy of QSM. Copyright © 2016 Elsevier Inc. All rights reserved.
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Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation
Amador, Ariadna; Huitron-Resendiz, Salvador; Roberts, Amanda J.; Kamenecka, Theodore M.; Solt, Laura A.; Burris, Thomas P.
2016-01-01
The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands. Recent studies in mice suggest that REV-ERB-specific synthetic agonists modulate metabolic activity as well as alter sleep architecture, inducing wakefulness during the light period. Therefore, these small molecules represent unique tools to extensively study REV-ERB regulation of sleep and wakefulness. In these studies, our aim was to further investigate the therapeutic potential of targeting the REV-ERBs for regulation of sleep by characterizing efficacy, and optimal dosing time of the REV-ERB agonist SR9009 using electroencephalographic (EEG) recordings. Applying different experimental paradigms in mice, our studies establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop when administered once a day over a three-day dosing regimen. Moreover, through use of a time response paradigm, we determined that although there is an optimal time for administration of SR9009 in terms of maximal efficacy, there is a 12-hour window in which SR9009 elicited a response. Our studies indicate that the REV-ERBs are potential therapeutic targets for treating sleep problems as those encountered as a consequence of shift work or jet lag. PMID:27603791
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NASA Astrophysics Data System (ADS)
Duan, Lingxun; Bagasra, Omar; Laughlin, Mark A.; Oakes, Joseph W.; Pomerantz, Roger J.
1994-05-01
Human immunodeficiency virus type 1 (HIV-1) has a complex life cycle, which has made it a difficult target for conventional therapeutic modalities. A single-chain antibody moiety, directed against the HIV-1 regulatory protein Rev, which rescues unspliced viral RNA from the nucleus of infected cells, has now been developed. This anti-Rev single-chain construct (SFv) consists of both light and heavy chain variable regions of an anti-Rev monoclonal antibody, which, when expressed intracellularly within human cells, potently inhibits HIV-1 replication. This intracellular SFv molecule is demonstrated to specifically antagonize Rev function. Thus, intracellular SFv expression, against a retroviral regulatory protein, may be useful as a gene therapeutic approach to combat HIV-1 infections.
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REV-ERB and ROR nuclear receptors as drug targets
Kojetin, Douglas J.; Burris, Thomas P.
2016-01-01
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm. The recent characterization of endogenous ligands for these former orphan nuclear receptors has stimulated the development of synthetic ligands and opened up the possibility of targeting these receptors to treat several diseases, including diabetes, atherosclerosis, autoimmunity and cancer. This Review focuses on the latest developments in ROR and REV-ERB pharmacology indicating that these nuclear receptors are druggable targets and that ligands targeting these receptors may be useful in the treatment of several disorders. PMID:24577401
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Complete set of essential parameters of an effective theory
NASA Astrophysics Data System (ADS)
Ioffe, M. V.; Vereshagin, V. V.
2018-04-01
The present paper continues the series [V. V. Vereshagin, True self-energy function and reducibility in effective scalar theories, Phys. Rev. D 89, 125022 (2014); , 10.1103/PhysRevD.89.125022A. Vereshagin and V. Vereshagin, Resultant parameters of effective theory, Phys. Rev. D 69, 025002 (2004); , 10.1103/PhysRevD.69.025002K. Semenov-Tian-Shansky, A. Vereshagin, and V. Vereshagin, S-matrix renormalization in effective theories, Phys. Rev. D 73, 025020 (2006), 10.1103/PhysRevD.73.025020] devoted to the systematic study of effective scattering theories. We consider matrix elements of the effective Lagrangian monomials (in the interaction picture) of arbitrary high dimension D and show that the full set of corresponding coupling constants contains parameters of both kinds: essential and redundant. Since it would be pointless to formulate renormalization prescriptions for redundant parameters, it is necessary to select the full set of the essential ones. This is done in the present paper for the case of the single scalar field.
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Reversible polymorphism-aware phylogenetic models and their application to tree inference.
Schrempf, Dominik; Minh, Bui Quang; De Maio, Nicola; von Haeseler, Arndt; Kosiol, Carolin
2016-10-21
We present a reversible Polymorphism-Aware Phylogenetic Model (revPoMo) for species tree estimation from genome-wide data. revPoMo enables the reconstruction of large scale species trees for many within-species samples. It expands the alphabet of DNA substitution models to include polymorphic states, thereby, naturally accounting for incomplete lineage sorting. We implemented revPoMo in the maximum likelihood software IQ-TREE. A simulation study and an application to great apes data show that the runtimes of our approach and standard substitution models are comparable but that revPoMo has much better accuracy in estimating trees, divergence times and mutation rates. The advantage of revPoMo is that an increase of sample size per species improves estimations but does not increase runtime. Therefore, revPoMo is a valuable tool with several applications, from speciation dating to species tree reconstruction. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Binding and thermodynamics of REV peptide-ctDNA interaction.
Upadhyay, Santosh Kumar
2017-03-01
The thermodynamics of DNA-ligand binding is important as it provides useful information to understand the details of binding processes. HIV-1 REV response element (RRE) located in the env coding region of the viral genome is reported to be well conserved across different HIV-1 isolates. In this study, the binding characteristics of Calf thymus DNA (ctDNA) and REV peptide from HIV-1 were investigated using spectroscopic (UV-visible, fluorescence, and circular dichroism (CD)) and isothermal titration calorimetric (ITC) techniques. Thermal stability and ligand binding properties of the ctDNA revealed that native ctDNA had a T m of 75.5 °C, whereas the ctDNA-REV peptide complex exhibited an incremental shift in the T m by 8 °C, indicating thermal stability of the complex. CD data indicated increased ellipticity due to large conformational changes in ctDNA molecule upon binding with REV peptide and two binding stoichiometric modes are apparent. The ctDNA experienced condensation due to large conformational changes in the presence of REV peptide and positive B→Ψ transition was observed at higher molar charge ratios. Fluorescence studies performed at several ligand concentrations revealed a gradual decrease in the fluorescence intensity of EtBr-bound ctDNA in response to increasing ligand concentrations. The fluorescence data further confirmed two stoichiometric modes of binding for ctDNA-REV peptide complex as previously observed with CD studies. The binding enthalpies were determined using ITC in the temperature range of 293 K-308 K. The ITC binding isotherm was exothermic at all temperatures examined, with low ΔH values indicating that the ctDNA-REV peptide interaction is driven largely by entropy. The heat capacity change (ΔC p ) was insignificant, an unusual finding in the area of DNA-peptide interaction studies. The variation in the values obtained for ΔH, ΔS, and ΔG with temperature further suggests that ctDNA-REV peptide interaction is entropically driven. ITC based analysis of salt dependence of binding constant gave a charge value (Z) = +4.01, as determined for the δlnK/δln[Na + ] parameter, suggesting the participation of only 3-4 Arg out of 11 Arg charge from REV peptide. The stoichiometry observed for the complex was three molar charge of REV peptide binding per molar charge of ctDNA. ITC based analysis further confirmed that the binding between ctDNA and REV peptide is governed by electrostatic interaction. Molecular interactions including H-bonding, van der Waals forces, and solvent molecules rearrangement, underlie the binding of REV peptide to ctDNA. © 2016 Wiley Periodicals, Inc.
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Tamavidin 2-REV: an engineered tamavidin with reversible biotin-binding capability.
Takakura, Yoshimitsu; Sofuku, Kozue; Tsunashima, Masako
2013-03-10
A biotin-binding protein with reversible biotin-binding capability is of great technical value in the affinity purification of biotinylated biomolecules. Although several proteins, chemically or genetically modified from avidin or streptavidin, with reversible biotin-binding have been reported, they have been problematic in one way or another. Tamavidin 2 is a fungal protein similar to avidin and streptavidin in biotin-binding. Here, a mutein, tamavidin 2-REV, was engineered from tamavidin 2 by replacing the serine at position 36 (S36) with alanine. S36 is thought to form a hydrogen bond with biotin in tamavidin 2/biotin complexes and two hydrogen bonds with V38 within the protein. Tamavidin 2-REV bound to biotin-agarose and was eluted with excess free biotin at a neutral pH. In addition, the model substrate biotinylated bovine serum albumin was efficiently purified from a crude extract from Escherichia coli by means of single-step affinity chromatography with tamavidin 2-REV-immobilized resin. Tamavidin 2-REV thus demonstrated reversible biotin-binding capability. The Kd value of tamavidin 2-REV to biotin was 2.8-4.4×10(-7)M.Tamavidin 2-REV retained other convenient characteristics of tamavidin 2, such as high-level expression in E. coli, resistance to proteases, and a neutral isoelectric point, demonstrating that tamavidin 2-REV is a powerful tool for the purification of biotinylated biomolecules. Copyright © 2013 Elsevier B.V. All rights reserved.
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Comment on "Many-body localization in Ising models with random long-range interactions"
NASA Astrophysics Data System (ADS)
Maksymov, Andrii O.; Rahman, Noah; Kapit, Eliot; Burin, Alexander L.
2017-11-01
This Comment is dedicated to the investigation of many-body localization in a quantum Ising model with long-range power-law interactions r-α, relevant for a variety of systems ranging from electrons in Anderson insulators to spin excitations in chains of cold atoms. It has earlier been argued [arXiv:cond-mat/0611387 (2005); Phys. Rev. B 91, 094202 (2015), 10.1103/PhysRevB.91.094202] that this model obeys the dimensional constraint suggesting the delocalization of all finite-temperature states in the thermodynamic limit for α ≤2 d in a d -dimensional system. This expectation conflicts with the recent numerical studies of the specific interacting spin model of Li et al. [Phys. Rev. A 94, 063625 (2016), 10.1103/PhysRevA.94.063625]. To resolve this controversy we reexamine the model of Li et al. [Phys. Rev. A 94, 063625 (2016), 10.1103/PhysRevA.94.063625] and demonstrate that the infinite-temperature states there obey the dimensional constraint. The earlier developed scaling theory for the critical system size required for delocalization is extended to small exponents 0 ≤α ≤d . The disagreements between the two works are explained by the nonstandard selection of investigated states in the ordered phase in the work of Li et al. [Phys. Rev. A 94, 063625 (2016)
10.1103/PhysRevA.94.063625]. -
Wingfield, P T; Stahl, S J; Payton, M A; Venkatesan, S; Misra, M; Steven, A C
1991-07-30
The high-level expression of HIV-1 Rev in Escherichia coli is described. Protein in crude bacterial extracts was dissociated from bound nucleic acid with urea. A simple purification and renaturation protocol, monitored by circular dichroism, is described which results in high yields of pure protein. The purified protein binds with high affinity to the Rev-responsive element mRNA and has nativelike spectroscopic properties. The protein exhibits concentration-dependent self-association as judged by analytical ultracentrifugation and gel filtration measurements. Purified Rev showed reversible heat-induced aggregation over the temperature range 0-30 degrees C. This hydrophobic-driven and nonspecific protein association was inhibited by low concentrations of sulfate ions. Rev solutions at greater than 80 micrograms/mL, incubated at 0-4 degrees C, slowly polymerized to form long hollow fibers of 20-nm diameter. Filament formation occurs at a lower protein concentration and more rapidly in the presence of Rev-responsive mRNA. The nucleic acid containing filaments are about 8 nm in diameter and up to 0.4 micron in length. On the basis of physical properties of the purified protein, we have suggested that in the nucleus of infected cells, Rev binding to the Rev-responsive region of env mRNA may be followed by helical polymerization of the protein which results in coating of the nucleic acid. Coated nucleic acid could be protected from splicing in the nucleus and exported to the cytoplasm.
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The Implementation of Cumulative Learning Theory in Calculating Triangular Prism and Tube Volumes
NASA Astrophysics Data System (ADS)
Muklis, M.; Abidin, C.; Pamungkas, M. D.; Masriyah
2018-01-01
This study aims at describing the application of cumulative learning theory in calculating the volume of a triangular prism and a tube as well as revealing the students’ responses toward the learning. The research method used was descriptive qualitative with elementary school students as the subjects of the research. Data obtained through observation, field notes, questionnaire, tests, and interviews. The results from the application of cumulative learning theory obtained positive students’ responses in following the learning and students’ learning outcomes was dominantly above the average. This showed that cumulative learning could be used as a reference to be implemented in learning, so as to improve the students’ achievement.
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NASA Astrophysics Data System (ADS)
Kapko, Vitaliy; Zhao, Zuofeng; Matyushov, Dmitry V.; Austen Angell, C.
2013-03-01
The ability of some liquids to vitrify during supercooling is usually seen as a consequence of the rates of crystal nucleation (and/or crystal growth) becoming small [D. R. Uhlmann, J. Non-Cryst. Solids 7, 337 (1972), 10.1016/0022-3093(72)90269-4] - and thus a matter of kinetics. However, there is evidence dating back to the empirics of coal briquetting for maximum trucking efficiency [D. Frenkel, Physics 3, 37 (2010), 10.1103/Physics.3.37] that some object shapes find little advantage in self-assembly to ordered structures - meaning random packings prevail. Noting that key studies of non-spherical object packing have never been followed from hard ellipsoids [A. Donev, F. H. Stillinger, P. M. Chaikin, and S. Torquato, Phys. Rev. Lett. 92, 255506 (2004), 10.1103/PhysRevLett.92.255506; A. Donev, I. Cisse, D. Sachs, E. A. Variano, F. H. Stillinger, R. Connelly, S. Torquato, and P. M. Chaikin, Science 303, 990 (2004), 10.1126/science.1093010] or spherocylinders [S. R. Williams and A. P. Philipse, Phys. Rev. E 67, 051301 (2003), 10.1103/PhysRevE.67.051301] (diatomics excepted [S.-H. Chong, A. J. Moreno, F. Sciortino, and W. Kob, Phys. Rev. Lett. 94, 215701 (2005), 10.1103/PhysRevLett.94.215701] into the world of molecules with attractive forces, we have made a molecular dynamics study of crystal melting and glass formation on the Gay-Berne (G-B) model of ellipsoidal objects [J. G. Gay and B. J. Berne, J. Chem. Phys. 74, 3316 (1981), 10.1063/1.441483] across the aspect ratio range of the hard ellipsoid studies. Here, we report that in the aspect ratio range of maximum ellipsoid packing efficiency, various G-B crystalline states that cannot be obtained directly from the liquid, disorder spontaneously near 0 K and transform to liquids without any detectable enthalpy of fusion. Without claiming to have proved the existence of single component examples, we use the present observations, together with our knowledge of non-ideal mixing effects, to discuss the probable existence of "ideal glassformers" - single or multicomponent liquids that vitrify before ever becoming metastable with respect to crystals. We find evidence that "ideal glassformer" systems might also be highly fragile systems, approaching the "ideal glass" condition. We link this to the high "volume fragility" behavior observed in recent hard dumbbell studies at similar length/diameter ratios [R. Zhang and K. S. Schweitzer, J. Chem. Phys. 133, 104902 (2010), 10.1063/1.3483601]. The discussion suggests some unusual systems for laboratory study. Using differential scanning calorimetry detection of fusion points Tm, liquidus temperatures Tl, and glass transition temperatures Tg, we describe a system that would seem incapable of crystallizing before glass transition, i.e., an "ideal glassformer." The existence of crystal-free routes to the glassy state will eliminate precrystalline fluctuations as a source of the dynamic heterogeneities that are generally considered important in the discussion of the "glassy state problem [P. W. Anderson, Science 267, 1615 (1995), 10.1126/science.267.5204.1615-e]."
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Song, Yue; Xia, Zhijun; Shen, Keng; Zhai, Xingyue
2013-05-01
To construct recombinant adenoviruses AdHT-rev-casp3 and Ad-rev-casp3, which express autocatalysis caspase-3 driven by human telomerase reverse transcriptase promoter and cytomegalovirus promoter, respectively; and to investigate their antitumor effects on ovarian cancer in vitro and in vivo. Cell viabilities were determined using the cell counting kit 8 and flow cytometry. Reverse transcriptase polymerase chain reaction and immunoblotting assays were used to detect cellular apoptotic activities after treatments. Tumor growth and survival of mice bearing AO cells were studied. AdHT-rev-casp3 significantly suppressed the survival of AO cells in a dose-dependent modality with a viability rate of 60.45% ± 7.8% at an multiplicity of infection (MOI) of 70 and 42.18 ± 5.3% at an MOI of 100, which was somewhat lower than that of the AO cells treated with Ad-rev-casp3 (32.28% ± 5.3% and 21.84% ± 3.4%, respectively). In contrast, AdHT-rev-casp3 induced little human umbilical vein epithelial cell (HUVEC) death with a viability rate of 98.52% ± 6.9% at an MOI of 70, whereas Ad-rev-casp3 induced significant cell death in HUVEC with a viability rate of 27.14% ± 5.4%. Additionally, AdHT-rev-casp3 (MOI = 70) caused significant apoptosis in AO cells with an apoptotic rate of 25.97%, whereas it caused undetectable apoptosis in HUVECs with the rate of only 1.75%. Ad-rev-casp3 (MOI = 70) caused strong apoptosis in both AO and HUVECs, with the rate of 35.82% and 38.12%, respectively. AdHT-rev-casp3 caused markedly higher levels of active caspase-3, causing no detectable active caspase-3 expression in HUVECs. The tumor growth suppression rate of AdHT-rev-casp3 was 54.94%, significantly higher than that of phosphate-buffered saline at the end point of the study. AdHT-rev-casp3 significantly improved the survival of mice receiving intraperitoneal inoculation of AO cells with little liver damage, with the mean survival of 177 ± 12 days. AdHT-rev-casp3 causes effective apoptosis with significant tumor selectivity, suppresses tumor growth, and improves the mouse survival with little liver toxicity. It can be a potent therapeutic agent for the tumor-targeting treatment of ovarian cancer.
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NASA Astrophysics Data System (ADS)
Sahai, Aakash A.; Tsung, Frank S.; Tableman, Adam R.; Mori, Warren B.; Katsouleas, Thomas C.
2013-10-01
The relativistically induced transparency acceleration (RITA) scheme of proton and ion acceleration using laser-plasma interactions is introduced, modeled, and compared to the existing schemes. Protons are accelerated with femtosecond relativistic pulses to produce quasimonoenergetic bunches with controllable peak energy. The RITA scheme works by a relativistic laser inducing transparency [Akhiezer and Polovin, Zh. Eksp. Teor. Fiz 30, 915 (1956); Kaw and Dawson, Phys. FluidsPFLDAS0031-917110.1063/1.1692942 13, 472 (1970); Max and Perkins, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.27.1342 27, 1342 (1971)] to densities higher than the cold-electron critical density, while the background heavy ions are stationary. The rising laser pulse creates a traveling acceleration structure at the relativistic critical density by ponderomotively [Lindl and Kaw, Phys. FluidsPFLDAS0031-917110.1063/1.1693437 14, 371 (1971); Silva , Phys. Rev. E1063-651X10.1103/PhysRevE.59.2273 59, 2273 (1999)] driving a local electron density inflation, creating an electron snowplow and a co-propagating electrostatic potential. The snowplow advances with a velocity determined by the rate of the rise of the laser's intensity envelope and the heavy-ion-plasma density gradient scale length. The rising laser is incrementally rendered transparent to higher densities such that the relativistic-electron plasma frequency is resonant with the laser frequency. In the snowplow frame, trace density protons reflect off the electrostatic potential and get snowplowed, while the heavier background ions are relatively unperturbed. Quasimonoenergetic bunches of velocity equal to twice the snowplow velocity can be obtained and tuned by controlling the snowplow velocity using laser-plasma parameters. An analytical model for the proton energy as a function of laser intensity, rise time, and plasma density gradient is developed and compared to 1D and 2D PIC OSIRIS [Fonseca , Lect. Note Comput. Sci.9783-540410.1007/3-540-47789-6_36 2331, 342 (2002)] simulations. We model the acceleration of protons to GeV energies with tens-of-femtoseconds laser pulses of a few petawatts. The scaling of proton energy with laser power compares favorably to other mechanisms for ultrashort pulses [Schreiber , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.97.045005 97, 045005 (2006); Esirkepov , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.92.175003 92, 175003 (2004); Silva , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.92.015002 92, 015002 (2004); Fiuza , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.109.215001 109, 215001 (2012)].
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Computation of fluid flow and pore-space properties estimation on micro-CT images of rock samples
NASA Astrophysics Data System (ADS)
Starnoni, M.; Pokrajac, D.; Neilson, J. E.
2017-09-01
Accurate determination of the petrophysical properties of rocks, namely REV, mean pore and grain size and absolute permeability, is essential for a broad range of engineering applications. Here, the petrophysical properties of rocks are calculated using an integrated approach comprising image processing, statistical correlation and numerical simulations. The Stokes equations of creeping flow for incompressible fluids are solved using the Finite-Volume SIMPLE algorithm. Simulations are then carried out on three-dimensional digital images obtained from micro-CT scanning of two rock formations: one sandstone and one carbonate. Permeability is predicted from the computed flow field using Darcy's law. It is shown that REV, REA and mean pore and grain size are effectively estimated using the two-point spatial correlation function. Homogeneity and anisotropy are also evaluated using the same statistical tools. A comparison of different absolute permeability estimates is also presented, revealing a good agreement between the numerical value and the experimentally determined one for the carbonate sample, but a large discrepancy for the sandstone. Finally, a new convergence criterion for the SIMPLE algorithm, and more generally for the family of pressure-correction methods, is presented. This criterion is based on satisfaction of bulk momentum balance, which makes it particularly useful for pore-scale modelling of reservoir rocks.
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Derivation of a hydrodynamic theory for mesoscale dynamics in microswimmer suspensions
NASA Astrophysics Data System (ADS)
Reinken, Henning; Klapp, Sabine H. L.; Bär, Markus; Heidenreich, Sebastian
2018-02-01
In this paper, we systematically derive a fourth-order continuum theory capable of reproducing mesoscale turbulence in a three-dimensional suspension of microswimmers. We start from overdamped Langevin equations for a generic microscopic model (pushers or pullers), which include hydrodynamic interactions on both small length scales (polar alignment of neighboring swimmers) and large length scales, where the solvent flow interacts with the order parameter field. The flow field is determined via the Stokes equation supplemented by an ansatz for the stress tensor. In addition to hydrodynamic interactions, we allow for nematic pair interactions stemming from excluded-volume effects. The results here substantially extend and generalize earlier findings [S. Heidenreich et al., Phys. Rev. E 94, 020601 (2016), 10.1103/PhysRevE.94.020601], in which we derived a two-dimensional hydrodynamic theory. From the corresponding mean-field Fokker-Planck equation combined with a self-consistent closure scheme, we derive nonlinear field equations for the polar and the nematic order parameter, involving gradient terms of up to fourth order. We find that the effective microswimmer dynamics depends on the coupling between solvent flow and orientational order. For very weak coupling corresponding to a high viscosity of the suspension, the dynamics of mesoscale turbulence can be described by a simplified model containing only an effective microswimmer velocity.
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Optical-bistability-enabled control of resonant light transmission for an atom-cavity system
NASA Astrophysics Data System (ADS)
Sawant, Rahul; Rangwala, S. A.
2016-02-01
The control of light transmission through a standing-wave Fabry-Pérot cavity containing atoms is theoretically and numerically investigated, when the cavity mode beam and an intersecting control beam are both close to specific atomic resonances. A four-level atomic system is considered and its interaction with the cavity mode is studied by solving for the cavity field and atomic state populations. The conditions for optical bistability of the atom-cavity system are obtained. The response of the intracavity intensity to an intersecting beam on atomic resonance is understood in the presence of stationary atoms (closed system) and nonstatic atoms (open system) in the cavity. The nonstatic system of atoms is modelled by adjusting the atomic state populations to represent the exchange of atoms in the cavity mode, which corresponds to a thermal environment where atoms are moving in and out of the cavity mode volume. The control behavior with three- and two-level atomic systems is also studied, and the rich physics arising out of these systems for closed and open atomic systems is discussed. The solutions to the models are used to interpret the steady-state and transient behavior observed by Sharma et al. [Phys. Rev. A 91, 043824 (2015)], 10.1103/PhysRevA.91.043824.
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NASA Astrophysics Data System (ADS)
Eclancher, Bernard; Arntz, Y.; Chambron, Jacques; Prat, Vincent; Perret, C.; Karman, Miklos; Pszota, Agnes; Nemeth, Laszlo
1999-10-01
A hand-size probe including 64 elementary 5 X 5 X 2 mm CdTe detectors has been optimized to detect the (gamma) tracer 99Tc in the heart left ventricle. The system, has been developed, not for imaging, allowing acquisitions at 33 Hz to describe the labeled blood volume variations. The (gamma) -counts variations were found accurately proportional to the known volume variations of an artificial ventricle paced at variable rate and systolic volume. Softwares for on line data monitoring and for post-processing have been developed for beat to beat assessment of cardiac performance at rest and during physical exercise. The evaluation of this probe has been performed on 5 subjects in the Nucl Dep of Balatonfured Cardiology Hospital. It appears that the probe needs to be better shielded to work properly in the hot environment of the ventricle, but can provide reliable ventriculography, even under heavy exercise load, although the ventricle volume itself is unknown.
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Quicklook overview of model changes in Melcor 2.2: Rev 6342 to Rev 9496
DOE Office of Scientific and Technical Information (OSTI.GOV)
Humphries, Larry L.
2017-05-01
MELCOR 2.2 is a significant official release of the MELCOR code with many new models and model improvements. This report provides the code user with a quick review and characterization of new models added, changes to existing models, the effect of code changes during this code development cycle (rev 6342 to rev 9496), a preview of validation results with this code version. More detailed information is found in the code Subversion logs as well as the User Guide and Reference Manuals.