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Sample records for em incisivo central

  1. De-centralized and centralized control for realistic EMS Maglev systems

    NASA Astrophysics Data System (ADS)

    Moawad, Mohamed M. Aly M.

    A comparative study of de-centralized and centralized controllers when used with real EMS Maglev Systems is introduced. This comparison is divided into two parts. Part I is concerned with numerical simulation and experimental testing on a two ton six-magnet EMS Maglev vehicle. Levitation and lateral control with these controllers individually and when including flux feedback control in combination with these controllers to enhance stability are introduced. The centralized controller is better than the de-centralized one when the system is exposed to a lateral disturbing force such as wind gusts. The flux feedback control when combined with de-centralized or centralized controllers does improve the stability and is more resistant and robust with respect to the air gap variations. Part II is concerned with the study of Maglev vehicle-girder dynamic interaction system and the comparison between these two controllers on this typical system based on performance and ride quality achieved. Numerical simulations of the ODU EMS Maglev vehicle interacting with girder are conducted with these two different controllers. The de-centralized and centralized control for EMS Maglev systems that interact with a flexible girder provides similar ride quality. Centralized control with flux feedback could be the best controller for the ODU Maglev system when operating on girder. The centralized control will guarantee the suppression of the undesired lateral displacements; hence it will provide smoother ride quality. Flux feedback will suppress air gap variations due to the track discontinuities.

  2. Improving Emergency Medical Services (EMS) in the United States Through Improved and Centralized Federal Coordination

    DTIC Science & Technology

    2011-03-01

    other emergencies. 4 • Public Awareness of the EMS Discipline. The public at large is not aware of the EMS structure in its community or at a higher...regard for its imperative role in community service. For this reason, placing EMS under the USFA at the federal level would cause EMS to still be...service to include EMS is appropriate, and in some cases, it is not. Not all communities have a dedicated fire service, which can make EMS provision

  3. The ISO 14001 EMS implementation process and its implications: A case study of Central Japan

    SciTech Connect

    Mohammed, Matouq

    2000-02-01

    This study aims to investigate the ISO 14001 implementation process and its implications for regional environmental management. The region of Central Japan was chosen for this case study. The study focuses on selected issues such as the: (1) trends and motives of private firms in the implementation of an ISO 14001-based environmental management system (EMS); (2) obstacles during system implementation; (3) role of the system in enhancing environmental performance within the certified organization; and (4) relation between the major stakeholders, local citizens, governments, and firms after adopting the system. To achieve these objectives, a questionnaire survey was mailed to all certified firms in the region. A 58% response was achieved overall. The results show that the main aims behind the adoption of ISO 14001 by firms in the Bhubu region are to improve the environmental aspects within the enterprises and to enhance the employees' environmental awareness and capacity. The results have also shown that the ISO 14001-based EMS has had a great effect on a firm's environmental status as certified firms have claimed that natural resources such as fuel, water, and paper consumption have been more efficiently managed after adopting the system. Implementation of the system causes the firms to consider the role of the local people and the government in more effectively involving the local people in the firm's daily environmental awareness among the local people. Adopting the system also promotes a better relation within the enterprises affiliated to the same group, such as more attention given by the parent firms towards other firms working for the same group, or branches--mainly small and medium sized enterprises--in the field of EMS. Finally, the results show that firms give serious consideration to their final products' impacts on the environment. In other words, attention is given to life cycle analysis (LCA) among certified firms.

  4. The ISO 14001 EMS Implementation Process and Its Implications: A Case Study of Central Japan.

    PubMed

    Mohammed

    2000-02-01

    / This study aims to investigate the ISO 14001 implementation process and its implications for regional environmental management. The region of Central Japan (known as Chubu in Japanese, which literally means center) was chosen for this case study. The study focuses on selected issues such as the: (1) trends and motives of private firms in the implementation of an ISO 14001-based environmental management system (EMS); (2) obstacles during system implementation; (3) role of the system in enhancing environmental performance within the certified organization; and (4) relation between the major stakeholders, local citizens, governments, and firms after adopting the system. To achieve these objectives, a questionnaire survey was mailed to all certified firms in the region. A 58% response was achieved overall. The results show that the main aims behind the adoption of ISO 14001 by firms in the Chubu region are to improve the environmental aspects within the enterprises and to enhance the employees' environmental awareness and capacity. The results have also shown that the ISO 14001-based EMS has had a great effect on a firm's environmental status as certified firms have claimed that natural resources such as fuel, water, and paper consumption have been more efficiently managed after adopting the system. Implementation of the system causes the firms to consider the role of the local people and the government in more effectively involving the local people in the firm's daily environmental activities. It also helps to enhance the environmental awareness among the local people. Adopting the system also promotes a better relation within the enterprises affiliated to the same group, such as more attention given by the parent firms (head offices) towards other firms working for the same group, or branches-mainly small and medium sized enterprises (SMEs)-in the field of EMS. Finally, the results show that firms give serious consideration to their final products' impacts on the

  5. Comparison of an Atomic Model and Its Cryo-EM Image at the Central Axis of a Helix.

    PubMed

    He, Jing; Zeil, Stephanie; Hallak, Hussam; McKaig, Kele; Kovacs, Julio; Wriggers, Willy

    2015-11-01

    Cryo-electron microscopy (cryo-EM) is an important biophysical technique that produces three-dimensional (3D) density maps at different resolutions. Because more and more models are being produced from cryo-EM density maps, validation of the models is becoming important. We propose a method for measuring local agreement between a model and the density map using the central axis of the helix. This method was tested using 19 helices from cryo-EM density maps between 5.5 Å and 7.2 Å resolution and 94 helices from simulated density maps. This method distinguished most of the well-fitting helices, although challenges exist for shorter helices.

  6. EMS-physicians' self reported airway management training and expertise; a descriptive study from the Central Region of Denmark.

    PubMed

    Rognås, Leif K; Hansen, Troels Martin

    2011-02-08

    Prehospital advanced airway management, including prehospital endotracheal intubation is challenging and recent papers have addressed the need for proper training, skill maintenance and quality control for emergency medical service personnel. The aim of this study was to provide data regarding airway management-training and expertise from the regional physician-staffed emergency medical service (EMS). The EMS in this part of The Central Region of Denmark is a two tiered system. The second tier comprises physician staffed Mobile Emergency Care Units. The medical directors of the programs supplied system data. A questionnaire addressing airway management experience, training and knowledge was sent to the EMS-physicians. There are no specific guidelines, standard operating procedures or standardised program for obtaining and maintaining skills regarding prehospital advanced airway management in the schemes covered by this study. 53/67 physicians responded; 98,1% were specialists in anesthesiology, with an average of 17,6 years of experience in anesthesiology, and 7,2 years experience as EMS-physicians. 84,9% reported having attended life support course(s), 64,2% an advanced airway management course. 24,5% fulfilled the curriculum suggested for Danish EMS physicians. 47,2% had encountered a difficult or impossible PHETI, most commonly in a patient in cardiac arrest or a trauma patient. Only 20,8% of the physicians were completely familiar with what back-up devices were available for airway management. In this, the first Danish study of prehospital advanced airway management, we found a high degree of experience, education and training among the EMS-physicians, but their equipment awareness was limited. Check-outs, guidelines, standard operating procedures and other quality control measures may be needed.

  7. EMS-physicians' self reported airway management training and expertise; a descriptive study from the Central Region of Denmark

    PubMed Central

    2011-01-01

    Background Prehospital advanced airway management, including prehospital endotracheal intubation is challenging and recent papers have addressed the need for proper training, skill maintenance and quality control for emergency medical service personnel. The aim of this study was to provide data regarding airway management-training and expertise from the regional physician-staffed emergency medical service (EMS). Methods The EMS in this part of The Central Region of Denmark is a two tiered system. The second tier comprises physician staffed Mobile Emergency Care Units. The medical directors of the programs supplied system data. A questionnaire addressing airway management experience, training and knowledge was sent to the EMS-physicians. Results There are no specific guidelines, standard operating procedures or standardised program for obtaining and maintaining skills regarding prehospital advanced airway management in the schemes covered by this study. 53/67 physicians responded; 98,1% were specialists in anesthesiology, with an average of 17,6 years of experience in anesthesiology, and 7,2 years experience as EMS-physicians. 84,9% reported having attended life support course(s), 64,2% an advanced airway management course. 24,5% fulfilled the curriculum suggested for Danish EMS physicians. 47,2% had encountered a difficult or impossible PHETI, most commonly in a patient in cardiac arrest or a trauma patient. Only 20,8% of the physicians were completely familiar with what back-up devices were available for airway management. Conclusions In this, the first Danish study of prehospital advanced airway management, we found a high degree of experience, education and training among the EMS-physicians, but their equipment awareness was limited. Check-outs, guidelines, standard operating procedures and other quality control measures may be needed. PMID:21303510

  8. Late Quaternary alluvial fans of Emli Valley in the Ecemiş Fault Zone, south central Turkey: Insights from cosmogenic nuclides

    NASA Astrophysics Data System (ADS)

    Akif Sarıkaya, M.; Yıldırım, Cengiz; Çiner, Attila

    2015-01-01

    Alluvial fans within the paraglacial Ecemiş River drainages on the Aladağlar Mountains in south central Turkey were studied using geomorphological, sedimentological, and chlorine-36 terrestrial cosmogenic nuclide (TCN) surface exposure dating methods to examine the timing of alluvial fan abandonment/incision, and to understand the role of climatic and tectonic processes in the region. These alluvial fan complexes are among the best-preserved succession of alluvial fans in Turkey and they were offset by the major strike-slip Ecemiş Fault of the Central Anatolian Fault Zone. The alluvial fans are mostly composed of well-lithified limestone cobbles (5 to 25 cm in size), and comprise crudely stratified thick beds with a total thickness reaching up to about 80 m. TCN surface exposure dating indicates that the oldest alluvial fan surface (Yalak Fan) was likely formed and subsequently abandoned latest by 136.0 ± 23.4 ka ago, largely on the transition of the Penultimate Glaciation (Marine Isotope Stage 6, MIS 6) to the Last Interglacial (MIS 5) (i.e. Termination II). The second set of alluvial fan (Emli Fan) was possibly developed during the Last Interglacial (MIS 5), and incised twice by between roughly 97.0 ± 13.8 and 81.2 ± 13.2 ka ago. A younger alluvial fan deposit placed on relatively older erosional terraces of the Emli Fan suggests that it may have been produced during the Last Glacial Cycle (MIS 2). These events are similar to findings from other fluvial and lacustrine deposits throughout central Anatolia. The incision times of the Ecemiş alluvial fan surfaces largely coincide with major climatic shifts from the cooler glacial periods to warmer interglacial/interstadial conditions. This indicates that alluvial fans were produced by outwash sediments of paleoglaciers during cooler conditions, and, later, when glaciers started to retreat due to a major warming event, the excess water released from the glaciers incised the pre-existing fan surfaces. An

  9. The 7 and 11 May 1984 earthquakes in Abruzzo-Latium (Central Italy): reappraisal of the existing macroseismic datasets according to the EMS98

    NASA Astrophysics Data System (ADS)

    Graziani, Laura; Tertulliani, Andrea; Maramai, Alessandra; Rossi, Antonio; Arcoraci, Luca

    2017-09-01

    The aim of this paper is to provide a complete and reliable macroseismic knowledge of the events that stroke a large area in Central Italy on 7 and 11 May 1984. Previous studies, together with original accounts integrated with new and unpublished information, have been gathered and examined in order to re-evaluate macroseismic intensities in terms of the European Macroseismic Scale (EMS98). New intensity maps have been compiled; the total number of localities with available information for both the shocks increases from 1254 of the previous study to 1576. On the basis of the new dataset, the macroseismic magnitude of the first shock is MW 5.6 which is lower than the previous macroseismic computation (MW 5.7). Moreover, the topic of assessing macroseismic intensity in the presence of multiple shocks has been also investigated, proposing an unconventional approach to presenting the macroseismic data: an overall picture of the cumulative effects produced by all the seismic sequence is given to support a partial but faithful reconstruction of the second shock. This approach is inspired by the common experience in interpreting historical seismic sequences and gives a picture of the impact of the 1984 events on the territory.

  10. The 7 and 11 May 1984 earthquakes in Abruzzo-Latium (Central Italy): reappraisal of the existing macroseismic datasets according to the EMS98

    NASA Astrophysics Data System (ADS)

    Graziani, Laura; Tertulliani, Andrea; Maramai, Alessandra; Rossi, Antonio; Arcoraci, Luca

    2017-05-01

    The aim of this paper is to provide a complete and reliable macroseismic knowledge of the events that stroke a large area in Central Italy on 7 and 11 May 1984. Previous studies, together with original accounts integrated with new and unpublished information, have been gathered and examined in order to re-evaluate macroseismic intensities in terms of the European Macroseismic Scale (EMS98). New intensity maps have been compiled; the total number of localities with available information for both the shocks increases from 1254 of the previous study to 1576. On the basis of the new dataset, the macroseismic magnitude of the first shock is MW 5.6 which is lower than the previous macroseismic computation (MW 5.7). Moreover, the topic of assessing macroseismic intensity in the presence of multiple shocks has been also investigated, proposing an unconventional approach to presenting the macroseismic data: an overall picture of the cumulative effects produced by all the seismic sequence is given to support a partial but faithful reconstruction of the second shock. This approach is inspired by the common experience in interpreting historical seismic sequences and gives a picture of the impact of the 1984 events on the territory.

  11. EPA LABORATORIES IMPLEMENT EMS PROGRAM

    EPA Science Inventory

    This paper highlights the breadth and magnitude of carrying out an effective Environmental Management System (EMS) program at the U.S. EPA's research and development laboratories. Federal research laboratories have unique operating challenges compared to more centralized industr...

  12. EMS & the DEA.

    PubMed

    Beeson, Jeff; Ayres, Chris

    2010-01-01

    It's clear that EMS medical directors and management staff must be vigilant in their oversight of implementation, administration and monitoring of controlled substances within their agencies to best serve the public and avoid running afoul of investigation and incurring significant penalties. Those potentially affected by the need for individual registrations of both emergency vehicles and central inventory systems should carefully monitor upcoming developments in the interpretation od DEA regulations.

  13. Central line infections - hospitals

    MedlinePlus

    ... infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired infection - central line infection; Patient safety - central ...

  14. Central Italy

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Clouds and haze cover most of the Italian peninsula in this view of central Italy (41.5N, 14.0E) but the Bay of Naples region with Mt. Vesuvius and the island of Capri are clear. The Adriatic Sea in the background separates Italy from the cloud covered Balkans of eastern Europe and the Tyrrhenian Sea in the foreground lies between the Italian mainland and the off scene islands of Corsica and Sardinia. Several aircraft contrails can also be seen.

  15. EMS Student Handbook.

    ERIC Educational Resources Information Center

    Ogle, Patrick

    This student guide is one of a series of self-contained materials for students enrolled in an emergency medical services (EMS) training program. Discussed in the individual sections of the guide are the following topics: the purpose and history of EMS professionals; EMS training, certification and examinations (national and state certification and…

  16. Central Campus

    NASA Image and Video Library

    2017-05-17

    A long exposure photograph of the new headquarters building, part of the Central Campus in the industrial area at NASA’s Kennedy Space Center in Florida. The nearly-complete seven-story, 200,000-square-foot facility will house about 500 NASA civil service and contractor employees. The building will be more energy efficient than the current Headquarters building and will feature the latest in office and administrative building technology to fulfill Kennedy's role as the premiere spaceport for NASA and, increasingly, commercial entities.

  17. Central pain.

    PubMed

    Singh, Supreet

    2014-12-01

    Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. The topic addressed in this issue is central pain, a neuropathic pain syndrome caused by a lesion in the brain or spinal cord that sensitizes one's perception of pain. It is a debilitating condition caused by various diseases such as multiple sclerosis, strokes, spinal cord injuries, or brain tumors. Varied symptoms and the use of pharmacological medicines and nonpharmacological therapies will be addressed.

  18. EM International. Volume 1

    SciTech Connect

    Not Available

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  19. Leveraging EMS and VPP

    DTIC Science & Technology

    2009-05-01

    Elements of EMS  International Standards Organization ( ISO ) 14001 , Environmental Management Systems  The Key Elements of EMS: - Policy - Planning...wingman-- ON and OFF duty Fully Conforming vs. Fully Implemented  “Fully Conforming”  Meets standards established in ISO 14001  ESOH council...e n c e Every airman looking out for his wingman-- ON and OFF duty EMS & VPP Commonalities Environmental Management System ISO 14001 : 2004 Voluntary

  20. EMS in the pueblos.

    PubMed

    Vigil, M A

    1994-02-01

    Imagine creating a movie by excerpting scenes from "Dances With Wolves," splicing it with footage from "Code 3" or "Emergency Response" and then flavoring the script with the mystery of a Tony Hillerman novel. A film producer would probably find it quite difficult to choreograph a finished product from such a compilation of material. To hundreds of Native American EMS providers, however, such a movie is played out every day in Indian country. And with this movie come some real-life problems, including trauma, which is the number-one cause of premature death among Native Americans. But a high trauma rate is just one of the challenges facing tribal EMS responders. There's also prolonged response and transport, the problems involved in maintaining the unique culture and standard of care, the challenges of tribal EMS administration and EMS education of Native American students, and the unsure future of Native American EMS. Beyond that, there's the fact that EMS is a s unique to each Indian reservation as are the cultures of the native peoples who reside on these lands. Yet while no two systems are alike, most tribal EMS providers face similar challenges.

  1. A Field-Based Aquatic Life Benchmark for Conductivity in Central Appalachian Streams (Final Report)

    EPA Science Inventory

    EPA announced the availability of the final report, <em>A Field-Based Aquatic Life Benchmark for Conductivity in Central Appalachian Streamsem>. This report describes a method to characterize the relationship between the extirpation (the effective extinction) of invertebrate g...

  2. A Field-Based Aquatic Life Benchmark for Conductivity in Central Appalachian Streams (Final Report)

    EPA Science Inventory

    EPA announced the availability of the final report, <em>A Field-Based Aquatic Life Benchmark for Conductivity in Central Appalachian Streamsem>. This report describes a method to characterize the relationship between the extirpation (the effective extinction) of invertebrate g...

  3. EMS in Mauritius.

    PubMed

    Ramalanjaona, Georges; Brogan, Gerald X

    2009-02-01

    Mauritius lies in the southwest Indian Ocean about 1250 miles from the African coast and 500 miles from Madagascar. Mauritius (estimated population 1,230,602) became independent from the United Kingdom in 1968 and has one of the highest GDP per capita in Africa. Within Mauritius there is a well established EMS system with a single 999 national dispatch system. Ambulances are either publicly or privately owned. Public ambulances are run by the Government (SAMU). Megacare is a private subscriber only ambulance service. The Government has recently invested in new technology such as telemedicine to further enhance the role of EMS on the island. This article describes the current state of EMS in Mauritius and depicts its development in the context of Government effort to decentralise and modernise the healthcare system.

  4. EMS -- Error Message Service

    NASA Astrophysics Data System (ADS)

    Rees, P. C. T.; Chipperfield, A. J.; Draper, P. W.

    This document describes the Error Message Service, EMS, and its use in system software. The purpose of EMS is to provide facilities for constructing and storing error messages for future delivery to the user -- usually via the Starlink Error Reporting System, ERR (see SUN/104). EMS can be regarded as a simplified version of ERR without the binding to any software environment (e.g., for message output or access to the parameter and data systems). The routines in this library conform to the error reporting conventions described in SUN/104. A knowledge of these conventions, and of the ADAM system (see SG/4), is assumed in what follows. This document is intended for Starlink systems programmers and can safely be ignored by applications programmers and users.

  5. National EMS Research Agenda.

    PubMed

    Sayre, M R; White, L J; Brown, L H; McHenry, S D

    2002-01-01

    Now, more than ever before, the spirit of the emergency services professional is recognized by people everywhere. Individuals from every walk of life comprehend the reality of the job these professionals do each day. Placing the safety of others above their own is their acknowledged responsibility. Rescue and treatment of ill and injured patients are their purpose as well as their gratification. The men and women who provide prehospital care are well aware of the unpredictable nature of emergency medical services (EMS). Prehospital care is given when and where it is needed: in urban settings with vertical challenges and gridlock; in rural settings with limited access; in confined spaces; within entrapments; or simply in the street, exposed to the elements. Despite the challenges, EMS professionals rise to the occasion to do their best with the resources available. Despite more than 30 years of dedicated service by thousands of EMS professionals, academic researchers, and public policy makers, the nation's EMS system is treating victims of illness and injury with little or no evidence that the care they provide is optimal. A national investment in the EMS research infrastructure is necessary to overcome obstacles currently impeding the accumulation of essential evidence of the effectiveness of EMS practice. Funding is required to train new researchers and to help them establish their careers. Financial backing is needed to support the development of effective prehospital treatments for the diseases that drive the design of the EMS system, including injury and sudden cardiac arrest. Innovative strategies to make EMS research easier to accomplish in emergency situations must be implemented. Researchers must have access to patient outcome information in order to evaluate and improve prehospital care. New biomedical and technical advances must be evaluated using scientific methodology. Research is the key to maintaining focus on improving the overall health of the

  6. Centralize Printing, and Save.

    ERIC Educational Resources Information Center

    McCormick, Kathleen

    1984-01-01

    Describes the operations of a centralized printing office in a California school district. Centralization greatly increased the efficiency and lowered the cost of generating publications, information services, newsletters, and press releases throughout the school year. (TE)

  7. Central Neuropathic Pain Syndromes.

    PubMed

    Watson, James C; Sandroni, Paola

    2016-03-01

    Chronic pain is common in patients with neurologic complications of a central nervous system insult such as stroke. The pain is most commonly musculoskeletal or related to obligatory overuse of neurologically unaffected limbs. However, neuropathic pain can result directly from the central nervous system injury. Impaired sensory discrimination can make it challenging to differentiate central neuropathic pain from other pain types or spasticity. Central neuropathic pain may also begin months to years after the injury, further obscuring recognition of its association with a past neurologic injury. This review focuses on unique clinical features that help distinguish central neuropathic pain. The most common clinical central pain syndromes-central poststroke pain, multiple sclerosis-related pain, and spinal cord injury-related pain-are reviewed in detail. Recent progress in understanding of the pathogenesis of central neuropathic pain is reviewed, and pharmacological, surgical, and neuromodulatory treatments of this notoriously difficult to treat pain syndrome are discussed.

  8. Central and peripheral demyelination

    PubMed Central

    Mehndiratta, Man Mohan; Gulati, Natasha Singh

    2014-01-01

    Several conditions cause damage to the inherently normal myelin of central nervous system, perepheral nervous system or both central and perepheral nervous system and hence termed as central demyelinating diseases, perepheral demyelinating diseases and combined central and perepheral demyelinating diseases respectively. Here we analysed and foccused on the etiology, prevalance, incidence and age of these demyelinating disorders. Clinical attention and various diagnostic tests are needed to adequately assess all these possibilities. PMID:24741263

  9. Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice

    PubMed Central

    Han, Zheng-lan; Pan, Jia-xin; Li, Xu-hui; Li, Ning; Tang, Hong-hai; Wang, Pei; Zheng, Ting; Chang, Xue-mei; Wang, Rui

    2014-01-01

    Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system on the supraspinal antinociceptive effects induced by the endogenous µ-opioid receptor agonists, endomorphin-1 (EM-1) and endomorphin-2 (EM-2). In the mouse tail-flick assay, intracerebroventricular injection of EM-1 induced antinociception via µ-opioid receptor while the antinociception of intracerebroventricular injected EM-2 was mediated by both µ- and κ-opioid receptors. In addition, central administration of NPFF significantly reduced EM-1-induced central antinociception, but enhanced EM-2-induced central antinociception. The results using the selective NPFF1 and NPFF2 receptor agonists indicated that the EM-1-modulating action of NPFF was mainly mediated by NPFF2 receptor, while NPFF potentiated EM-2-induecd antinociception via both NPFF1 and NPFF2 receptors. To further investigate the roles of µ- and κ-opioid systems in the opposite effects of NPFF on central antinociception of endomprphins, the µ- and κ-opioid receptors selective agonists DAMGO and U69593, respectively, were used. Our results showed that NPFF could reduce the central antinociception of DAMGO via NPFF2 receptor and enhance the central antinociception of U69593 via both NPFF1 and NPFF2 receptors. Taken together, our data demonstrate that NPFF exerts opposite effects on central antinociception of endomorphins and provide the first evidence that NPFF potentiate antinociception of EM-2, which might result from the interaction between NPFF and κ-opioid systems. PMID:25090615

  10. The Effects of Mountaintop Mines and Valley Fills on Aquatic Ecosystems of the Central Appalachian Coalfields (2011 Final)

    EPA Science Inventory

    EPA announced the availability of the final report, <em>The Effects of Mountaintop Mines and Valley Fills on Aquatic Ecosystems of the Central Appalachian Coalfieldsem>. This report assesses the state of the science on the environmental impacts of mountaintop mines and valley ...

  11. The Effects of Mountaintop Mines and Valley Fills on Aquatic Ecosystems of the Central Appalachian Coalfields (2011 Final)

    EPA Science Inventory

    EPA announced the availability of the final report, <em>The Effects of Mountaintop Mines and Valley Fills on Aquatic Ecosystems of the Central Appalachian Coalfieldsem>. This report assesses the state of the science on the environmental impacts of mountaintop mines and valley ...

  12. The EM Earthquake Precursor

    NASA Astrophysics Data System (ADS)

    Jones, K. B., II; Saxton, P. T.

    2013-12-01

    Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After the 1989 Loma Prieta Earthquake, American earthquake investigators predetermined magnetometer use and a minimum earthquake magnitude necessary for EM detection. This action was set in motion, due to the extensive damage incurred and public outrage concerning earthquake forecasting; however, the magnetometers employed, grounded or buried, are completely subject to static and electric fields and have yet to correlate to an identifiable precursor. Secondly, there is neither a networked array for finding any epicentral locations, nor have there been any attempts to find even one. This methodology needs dismissal, because it is overly complicated, subject to continuous change, and provides no response time. As for the minimum magnitude threshold, which was set at M5, this is simply higher than what modern technological advances have gained. Detection can now be achieved at approximately M1, which greatly improves forecasting chances. A propagating precursor has now been detected in both the field and laboratory. Field antenna testing conducted outside the NE Texas town of Timpson in February, 2013, detected three strong EM sources along with numerous weaker signals. The antenna had mobility, and observations were noted for recurrence, duration, and frequency response. Next, two

  13. Martian Central Pit Craters

    NASA Technical Reports Server (NTRS)

    Hillman, E.; Barlow, N. G.

    2005-01-01

    Impact craters containing central pits are rare on the terrestrial planets but common on icy bodies. Mars is the exception among the terrestrial planets, where central pits are seen on crater floors ( floor pits ) as well as on top of central peaks ( summit pits ). Wood et al. [1] proposed that degassing of subsurface volatiles during crater formation produced central pits. Croft [2] argued instead that central pits might form during the impact of volatile-rich comets. Although central pits are seen in impact craters on icy moons such as Ganymede, they do show some significant differences from their martian counterparts: (a) only floor pits are seen on Ganymede, and (b) central pits begin to occur at crater diameters where the peak ring interior morphology begins to appear in terrestrial planet craters [3]. A study of craters containing central pits was conducted by Barlow and Bradley [4] using Viking imagery. They found that 28% of craters displaying an interior morphology on Mars contain central pits. Diameters of craters containing central pits ranged from 16 to 64 km. Barlow and Bradley noted that summit pit craters tended to be smaller than craters containing floor pits. They also noted a correlation of central pit craters with the proposed rings of large impact basins. They argued that basin ring formation fractured the martian crust and allowed subsurface volatiles to concentrate in these locations. They favored the model that degassing of the substrate during crater formation was responsible for central pit formation due to the preferential location of central pit craters along these basin rings.

  14. Central line complications

    PubMed Central

    Kornbau, Craig; Lee, Kathryn C; Hughes, Gwendolyn D; Firstenberg, Michael S

    2015-01-01

    Central venous access is a common procedure performed in many clinical settings for a variety of indications. Central lines are not without risk, and there are a multitude of complications that are associated with their placement. Complications can present in an immediate or delayed fashion and vary based on type of central venous access. Significant morbidity and mortality can result from complications related to central venous access. These complications can cause a significant healthcare burden in cost, hospital days, and patient quality of life. Advances in imaging, access technique, and medical devices have reduced and altered the types of complications encountered in clinical practice; but most complications still center around vascular injury, infection, and misplacement. Recognition and management of central line complications is important when caring for patients with vascular access, but prevention is the ultimate goal. This article discusses common and rare complications associated with central venous access, as well as techniques to recognize, manage, and prevent complications. PMID:26557487

  15. Central Pit Crater

    NASA Image and Video Library

    2015-11-13

    Crater floors can have a range of features, from flat to a central peak or a central pit. This image from NASA 2001 Mars Odyssey spacecraft shows an unnamed crater in Terra Sabaea has a central pit. This unnamed crater in Terra Sabaea has a central pit. The different floor features develop do due several factors, including the size of the impactor, the geology of the surface material and the geology of the materials at depth. Orbit Number: 60737 Latitude: 22.3358 Longitude: 61.2019 Instrument: VIS Captured: 2015-08-23 20:13 http://photojournal.jpl.nasa.gov/catalog/PIA20092

  16. Color a bright energy picture with EMS controls

    SciTech Connect

    Not Available

    1985-09-01

    After 80 years in the crayon-manufacturing business, Binney and Smith found that more than 50% of their staggering annual utility costs were being generated by non-production loads. To curtail waste, they installed an expandable EMS which controls energy in the company's two separate, multi-building facilities from one central location. The system selected was an AI2100/MAX System manufactured by American Auto-Matrix, Export, PA.

  17. Idiopathic central diabetes Insipidus.

    PubMed

    Grace, Mary; Balachandran, Venu; Menon, Sooraj

    2011-10-01

    Idiopathic central diabetes insipidus (CDI) is a rare disorder characterized clinically by polyuria and polydipsia, and an abnormal urinary concentration without any identified etiology. We report a case of central diabetes insipidus in a 60-year-old lady in the absence of secondary causes like trauma, infection, and infiltrative disorders of brain.

  18. Central College Data Book.

    ERIC Educational Resources Information Center

    Central Coll., McPherson, KS.

    Tabulated data relevant to several aspects of Central College, a private two-year church-related institution, are compiled in this data book. Content includes statistical data and information on: (1) the purposes, objectives, history, and accreditation and memberships of Central College; (2) full- and part-time faculty, faculty utilization,…

  19. Central diffraction at ALICE

    NASA Astrophysics Data System (ADS)

    Lämsä, J. W.; Orava, R.

    2011-02-01

    The ALICE experiment is shown to be well suited for studies of exclusive final states from central diffractive reactions. The gluon-rich environment of the central system allows detailed QCD studies and searches for exotic meson states, such as glueballs, hybrids and new charmonium-like states. It would also provide a good testing ground for detailed studies of heavy quarkonia. Due to its central barrel performance, ALICE can accurately measure the low-mass central systems with good purity. The efficiency of the Forward Multiplicity Detector (FMD) and the Forward Shower Counter (FSC) system for detecting rapidity gaps is shown to be adequate for the proposed studies. With this detector arrangement, valuable new data can be obtained by tagging central diffractive processes.

  20. Why do Emergency Medical Services (EMS) Professionals Leave EMS?

    PubMed

    Blau, Gary; Chapman, Susan A

    2016-12-01

    The objective was to determine why Emergency Medical Technician (EMT)-Basics and Paramedics leave the Emergency Medical Services (EMS) workforce. Data were collected through annual surveys of nationally registered EMT-Basics and Paramedics from 1999 to 2008. Survey items dealing with satisfaction with the EMS profession, likelihood of leaving the profession, and likelihood of leaving their EMS job were assessed for both EMT-Basics and Paramedics, along with reasons for leaving the profession. Individuals whose responses indicated that they were not working in EMS were mailed a special exit survey to determine the reasons for leaving EMS. The likelihood of leaving the profession in the next year was low for both EMT-Basics and Paramedics. Although overall satisfaction levels with the profession were high, EMT-Basics were significantly more satisfied than Paramedics. The most important reasons for leaving the profession were choosing to pursue further education and moving to a new location. A desire for better pay and benefits was a significantly more important reason for EMT-Paramedics' exit decisions than for EMT-Basics. Given the anticipated increased demand for EMS professionals in the next decade, continued study of issues associated with retention is strongly recommended. Some specific recommendations and suggestions for promoting retention are provided. Blau G , Chapman SA . Why do Emergency Medical Services (EMS) professionals leave EMS? Prehosp Disaster Med. 2016;31(Suppl. 1):s105-s111.

  1. Identified EM Earthquake Precursors

    NASA Astrophysics Data System (ADS)

    Jones, Kenneth, II; Saxton, Patrick

    2014-05-01

    Many attempts have been made to determine a sound forecasting method regarding earthquakes and warn the public in turn. Presently, the animal kingdom leads the precursor list alluding to a transmission related source. By applying the animal-based model to an electromagnetic (EM) wave model, various hypotheses were formed, but the most interesting one required the use of a magnetometer with a differing design and geometry. To date, numerous, high-end magnetometers have been in use in close proximity to fault zones for potential earthquake forecasting; however, something is still amiss. The problem still resides with what exactly is forecastable and the investigating direction of EM. After a number of custom rock experiments, two hypotheses were formed which could answer the EM wave model. The first hypothesis concerned a sufficient and continuous electron movement either by surface or penetrative flow, and the second regarded a novel approach to radio transmission. Electron flow along fracture surfaces was determined to be inadequate in creating strong EM fields, because rock has a very high electrical resistance making it a high quality insulator. Penetrative flow could not be corroborated as well, because it was discovered that rock was absorbing and confining electrons to a very thin skin depth. Radio wave transmission and detection worked with every single test administered. This hypothesis was reviewed for propagating, long-wave generation with sufficient amplitude, and the capability of penetrating solid rock. Additionally, fracture spaces, either air or ion-filled, can facilitate this concept from great depths and allow for surficial detection. A few propagating precursor signals have been detected in the field occurring with associated phases using custom-built loop antennae. Field testing was conducted in Southern California from 2006-2011, and outside the NE Texas town of Timpson in February, 2013. The antennae have mobility and observations were noted for

  2. A new preparedness policy for EMS logistics.

    PubMed

    Lee, Seokcheon

    2017-03-01

    Response time in emergency medical services (EMS) is defined as the interval for an ambulance to arrive the scene after receipt of a 911 call. When several ambulances are available upon the receipt of a new call, a decision of selecting an ambulance has to be made in an effort to reduce response time. Dispatching the closest unit available is commonly used in practice; however, recently the Preparedness policy was designed that is in a simplistic form yet being capable of securing a long-term efficiency. This research aims to improve the Preparedness policy, resolving several critical issues inherent in the current form of the policy. The new Preparedness policy incorporates a new metric of preparedness based on the notion of centrality and involves a tuning parameter, weight on preparedness, which has to be appropriately chosen according to operational scenario. Computational experiment shows that the new policy significantly improves the former policy robustly in various scenarios.

  3. Central ballast tanker design

    SciTech Connect

    1997-01-01

    The purpose of this paper is to present the CENTRAL BALLAST TANKER Design. This design is intended to reduce the volume of oil spilled from tankers by giving the crew a tanker properly designed and equipped to allow large quantities of oil from ruptured tank(s) to flow safely to a fully-inerted central ballast tank. In addition to reducing the volume of oil spilled, the design also addresses many of the shortcomings of the DOUBLE HULL DESIGN which are increasingly becoming a concern. The following is a brief review of the development of the CENTRAL BALLAST TANKER. The simple operational features, stability, low cost and ease of maintenance of the single hull tanker were important and can be retained with the CENTRAL BALLAST DESIGN.

  4. Central sleep apnea

    MedlinePlus

    ... Ramar K, et al. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. SLEEP . 2012;35:17-40. Clodagh MR, Bradley TD. ...

  5. Central nervous system

    MedlinePlus

    The central nervous system is composed of the brain and spinal cord. Your brain and spinal cord serve as the main "processing center" for your entire nervous system. They control all the workings of your body.

  6. Pigmented central neurocytoma.

    PubMed

    Kiehl, Tim-Rasmus; Kalkanis, Steven N; Louis, David N

    2004-06-01

    Central neurocytoma is a low-grade neuronal neoplasm that occurs most often within the lateral ventricles. We report the case of a 60-year-old woman who presented with gait problems, headache and memory loss. Preoperative evaluation demonstrated a heterogeneous, hypervascular and partially cystic mass in the left lateral ventricle. Histopathological examination revealed characteristic features of central neurocytoma, including immunoreactivity for synaptophysin, as well as the unusual feature of abundant pigment in the cytoplasm of tumor cells. Special stains revealed iron, consistent with hemosiderin, but found no evidence of melanin or melanosomes. Previous reports of pigmented central neurocytoma have described the presence of lipofuscin or neuromelanin. To our knowledge, the present case represents the first example of pigmented central neurocytoma secondary to hemosiderin deposition.

  7. Central Peak Crater

    NASA Image and Video Library

    2010-10-07

    As crater size increases, craters become more complex. This moderate size crater contains a central peak, created by rebound of molten material just following the impact. This image was captured by NASA Mars Odyssey on Sept. 8, 2010.

  8. TACS Central Control Facility.

    DTIC Science & Technology

    1981-02-12

    Central Control Facility 6 3. System Management Data Flow 7 B. Hardware Operating Environment 9 1. Computer 9 2. TACS Interfaces 9 3. Other Central...TERMINATION TIMING 131 Appendix C SYSTEM MANAGEMENT DATA FORMATS 135 Appendix D FIVE- AND NINE-SLOT SYSTEM IMPLEMENTATION DIFFERENCES 147 Appendix E...control burst management ) 26 2-7 Call Progress Messages 29 2-8 Flowchart of Assignment/Blockage Decision Process for All-Member Net Requests 30 2-9

  9. Central Diffraction in ALICE

    SciTech Connect

    Schicker, R.

    2011-07-15

    The ALICE experiment consists of a central barrel in the pseudorapidity range -0.9<{eta}<0.9 and of additional detectors covering about 3 units of pseudorapidity on either side of the central barrel. Such a geometry allows the tagging of single and double gap events. The status of the analysis of such diffractive events in proton-proton collisions at {radical}(s) = 7 TeV is presented.

  10. Balanced Centrality of Networks.

    PubMed

    Debono, Mark; Lauri, Josef; Sciriha, Irene

    2014-01-01

    There is an age-old question in all branches of network analysis. What makes an actor in a network important, courted, or sought? Both Crossley and Bonacich contend that rather than its intrinsic wealth or value, an actor's status lies in the structures of its interactions with other actors. Since pairwise relation data in a network can be stored in a two-dimensional array or matrix, graph theory and linear algebra lend themselves as great tools to gauge the centrality (interpreted as importance, power, or popularity, depending on the purpose of the network) of each actor. We express known and new centralities in terms of only two matrices associated with the network. We show that derivations of these expressions can be handled exclusively through the main eigenvectors (not orthogonal to the all-one vector) associated with the adjacency matrix. We also propose a centrality vector (SWIPD) which is a linear combination of the square, walk, power, and degree centrality vectors with weightings of the various centralities depending on the purpose of the network. By comparing actors' scores for various weightings, a clear understanding of which actors are most central is obtained. Moreover, for threshold networks, the (SWIPD) measure turns out to be independent of the weightings.

  11. CENTRAL PLATEAU REMEDIATION

    SciTech Connect

    ROMINE, L.D.

    2006-02-01

    A systematic approach to closure planning is being implemented at the Hanford Site's Central Plateau to help achieve the goal of closure by the year 2035. The overall objective of Central Plateau remediation is to protect human health and the environment from the significant quantity of contaminated material that resulted from decades of plutonium production in support of the nation's defense. This goal will be achieved either by removing contaminants or placing the residual contaminated materials in a secure configuration that minimizes further migration to the groundwater and reduces the potential for inadvertent intrusion into contaminated sites. The approach to Central Plateau cleanup used three key concepts--closure zones, closure elements, and closure process steps--to create an organized picture of actions required to complete remediation. These actions were merged with logic ties, constraints, and required resources to produce an integrated time-phased schedule and cost profile for Central Plateau closure. Programmatic risks associated with implementation of Central Plateau closure were identified and analyzed. Actions to mitigate the most significant risks are underway while high priority remediation projects continue to make progress.

  12. Reservoir characterization and steam flood monitoring with crosshole EM

    SciTech Connect

    Wilt, M.; Torres-Verdin, C.

    1995-06-01

    Crosshole electromagnetic (EM) imaging is applied to reservoir characterization and steam flood monitoring in a central California oil field. Steam was injected into three stacked eastward-dipping, unconsolidated oil sands within the upper 200 m. The steam plume is expected to develop as an ellipse aligned with the regional northwest-southeast strike. EM measurements were made from two fiberglass-cased observation wells straddling the steam injector on a northeast-southwest profile using the LLNL frequency domain crosshole EM system. Field data were collected before the initiation of a steam drive to map the distribution of the oil sands and then 6 and 12 months later to monitor the progress of the steam chest. Resistivity images derived from the EM data before steam injection clearly delineate the distribution and dipping structure on the target oil sands. Difference images, from data collected before and after steam flooding, show resistivity changes that indicate that the steam chest has developed only in the deeper oil sands although steam injection occurred in all three sand layers.

  13. Central auditory imperception.

    PubMed

    Snow, J B; Rintelmann, W F; Miller, J M; Konkle, D F

    1977-09-01

    The development of clinically applicable techniques for the evaluation of hearing impairment caused by lesions of the central auditory pathways has increased clinical interest in the anatomy and physiology of these pathways. A conceptualization of present understanding of the anatomy and physiology of the central auditory pathways is presented. Clinical tests based on reduction of redundancy of the speech message, degradation of speech and binaural interations are presented. Specifically performance-intensity functions, filtered speech tests, competing message tests and time-compressed speech tests are presented with the emphasis on our experience with time-compressed speech tests. With proper use of these tests not only can central auditory impairments by detected, but brain stem lesions can be distinguished from cortical lesions.

  14. Hale Central Peak

    NASA Technical Reports Server (NTRS)

    2004-01-01

    19 September 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows some of the mountains that make up the central peak region of Hale Crater, located near 35.8oS, 36.5oW. Dark, smooth-surfaced sand dunes are seen to be climbing up the mountainous slopes. The central peak of a crater consists of rock brought up during the impact from below the crater floor. This autumn image is illuminated from the upper left and covers an area approximately 3 km (1.9 mi) across.

  15. Central venous access.

    PubMed

    Ganeshan, Arul; Warakaulle, Dinuke R; Uberoi, Raman

    2007-01-01

    Central venous access plays an important role in the management of an ever-increasing population of patients ranging from those that are critically ill to patients with difficult clinical access. Interventional radiologists are key in delivering this service and should be familiar with the wide range of techniques and catheters now available to them. A comprehensive description of these catheters with regard to indications, technical aspects of catheterization, success rates, and associated early and late complications, as well as a review of various published guidelines on central venous catheter insertion are given in this article.

  16. CENTRALIZATION AND HIGHER EDUCATION.

    ERIC Educational Resources Information Center

    MCKEAN, ROLAND N.

    SUGGESTED COSTS AND BENEFITS OF CENTRALIZED AUTHORITY IN HIGHER EDUCATION AS THEY AFFECT THE BEHAVIOR OF LEGISLATORS, ADMINISTRATORS, VOTERS, TEACHERS, AND STUDENTS, WERE EXAMINED BY COMPARING POLICIES OF DIFFERENT INSTITUTIONS (TWO MULTIVERSITIES OR COORDINATED STATE COLLEGE SYSTEMS, TWO RELATIVELY INDEPENDENT PUBLIC UNIVERSITIES IN ONE STATE,…

  17. CENTRALIZATION OF CAMPUS CONTROLS.

    ERIC Educational Resources Information Center

    1967

    A COLLEGE CAMPUS HAVING A LARGE NUMBER OF SEPARATE BUILDINGS WITH ONE BASIC HEATING AND COOLING SYSTEM IS AN IDEAL SITUATION FOR REALIZING GREAT BENEFITS FROM CENTRALIZED BUILDING CONTROL SYSTEMS. TYPICAL REQUIREMENTS AND ADVANTAGES OF SUCH SYSTEMS ARE DISCUSSED BRIEFLY AND DESCRIPTIONS OF THE SYSTEM AT FOUR MAJOR UNIVERSITIES ARE GIVEN. THIS…

  18. Ghrelin in central neurons.

    PubMed

    Ferrini, F; Salio, C; Lossi, L; Merighi, A

    2009-03-01

    Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, is released in the bloodstream in response to a negative energetic status. Since discovery, the hypothalamus was identified as the main source of ghrelin in the CNS, and effects of the peptide have been mainly observed in this area of the brain. In recent years, an increasing number of studies have reported ghrelin synthesis and effects in specific populations of neurons also outside the hypothalamus. Thus, ghrelin activity has been described in midbrain, hindbrain, hippocampus, and spinal cord. The spectrum of functions and biological effects produced by the peptide on central neurons is remarkably wide and complex. It ranges from modulation of membrane excitability, to control of neurotransmitter release, neuronal gene expression, and neuronal survival and proliferation. There is not at present a general consensus concerning the source of ghrelin acting on central neurons. Whereas it is widely accepted that the hypothalamus represents the most important endogenous source of the hormone in CNS, the existence of extra-hypothalamic ghrelin-synthesizing neurons is still controversial. In addition, circulating ghrelin can theoretically be another natural ligand for central ghrelin receptors. This paper gives an overview on the distribution of ghrelin and its receptor across the CNS and critically analyses the data available so far as regarding the effects of ghrelin on central neurotransmission.

  19. Multicultural Central Asia.

    ERIC Educational Resources Information Center

    Boyle, Eric D.

    This article addresses the multicultural aspect of Central Asia in response to the discussion on diversity in U.S. classrooms. Many areas of the world are more diverse than the U.S., and these areas experience successes and failures with many of the same issues the U.S. is currently struggling with. Comparing the U.S. diversity debate with similar…

  20. Education in Central America.

    ERIC Educational Resources Information Center

    Waggoner, George R.; Waggoner, Barbara Ashton

    The first chapter of this book describes the physical and cultural environment of Central America and includes analytical comments showing the complexity of the problems confronting the region. Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica, and Panama are then treated in separate chapters including: 1) political, economic, social and…

  1. The central hardwood forest

    Treesearch

    F. Bryan Clark

    1989-01-01

    The central hardwood forest covers a vast area of the United States where the dominant native vegetation is hardwood trees. It is one of the largest forest areas in the country and contains about 100 million acres. The forests include more than 70 hardwood tree species, several conifers, many shrubs and herbaceous plants, and a large number of animal species.

  2. Central hardwood notes

    Treesearch

    F. Bryan Clark; Jay G. Hutchinson

    1989-01-01

    The central hardwood forest covers a vast area of the United States where the dominant native vegetation is hardwood trees. It is one of the largest forest areas in the country and contains about 100 million acres. The forests include more than 70 hardwood tree species, several conifers, many shrubs and herbaceaous plants, and a large number of animal species. This...

  3. Central College Perspectives.

    ERIC Educational Resources Information Center

    Knapp, Wesley L.; Hawkins, Calvin H.

    Institutional data are presented which reflect five-year trends in the characteristics of Central College, a two-year institution established by members of the Free Methodist Church of North America in 1884. Data tables present a profile of the faculty with figures for 1972 through 1977 for the following: number and characteristics of full- and…

  4. Central Exclusive Dijet Production

    SciTech Connect

    Dechambre, A.; Cudell, J. R.; Ivanov, I. P.; Hernandez, O.

    2008-08-29

    The ingredients of central exclusive production cross section include large perturbative corrections and soft quantities that must be parametrized and fitted to data. In this talk, we summarize the results of a study of the uncertainties coming from these ingredients, in the case of exclusive dijet production.

  5. Ghrelin in Central Neurons

    PubMed Central

    Ferrini, F; Salio, C; Lossi, L; Merighi, A

    2009-01-01

    Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, is released in the bloodstream in response to a negative energetic status. Since discovery, the hypothalamus was identified as the main source of ghrelin in the CNS, and effects of the peptide have been mainly observed in this area of the brain. In recent years, an increasing number of studies have reported ghrelin synthesis and effects in specific populations of neurons also outside the hypothalamus. Thus, ghrelin activity has been described in midbrain, hindbrain, hippocampus, and spinal cord. The spectrum of functions and biological effects produced by the peptide on central neurons is remarkably wide and complex. It ranges from modulation of membrane excitability, to control of neurotransmitter release, neuronal gene expression, and neuronal survival and proliferation. There is not at present a general consensus concerning the source of ghrelin acting on central neurons. Whereas it is widely accepted that the hypothalamus represents the most important endogenous source of the hormone in CNS, the existence of extra-hypothalamic ghrelin-synthesizing neurons is still controversial. In addition, circulating ghrelin can theoretically be another natural ligand for central ghrelin receptors. This paper gives an overview on the distribution of ghrelin and its receptor across the CNS and critically analyses the data available so far as regarding the effects of ghrelin on central neurotransmission. PMID:19721816

  6. Environmental Restoration and Waste Management (EM) program: An introduction

    SciTech Connect

    Not Available

    1990-12-01

    This booklet introduces the reader to the mission and functions of a major new unit within the US Department of Energy (DOE): the Office of Environmental Restoration and Waste Management (EM). The Secretary of Energy established EM in November 1989, implementing a central purpose of DOE's first annual Environmental Restoration and Waste Management Five-Year Plan, which had appeared three months earlier. The contents of this booklet, and their arrangement, reflect the annual update of the Five-Year Plan. The Five-Year Plan supports DOE's strategy for meeting its 30-year compliance and cleanup goal. This strategy involves: focusing DOE's activities on eliminating or reducing known or recognized potential risks to worker and public health and the environment, containing or isolating, removing, or detoxifying onsite and offsite contamination, and developing technology to achieve DOE's environmental goals.

  7. Busca de estruturas em grandes escalas em altos redshifts

    NASA Astrophysics Data System (ADS)

    Boris, N. V.; Sodrã©, L., Jr.; Cypriano, E.

    2003-08-01

    A busca por estruturas em grandes escalas (aglomerados de galáxias, por exemplo) é um ativo tópico de pesquisas hoje em dia, pois a detecção de um único aglomerado em altos redshifts pode por vínculos fortes sobre os modelos cosmológicos. Neste projeto estamos fazendo uma busca de estruturas distantes em campos contendo pares de quasares próximos entre si em z Â3 0.9. Os pares de quasares foram extraídos do catálogo de Véron-Cetty & Véron (2001) e estão sendo observados com os telescópios: 2,2m da University of Hawaii (UH), 2,5m do Observatório de Las Campanas e com o GEMINI. Apresentamos aqui a análise preliminar de um par de quasares observado nos filtros i'(7800 Å) e z'(9500 Å) com o GEMINI. A cor (i'-z') mostrou-se útil para detectar objetos "early-type" em redshifts menores que 1.1. No estudo do par 131046+0006/J131055+0008, com redshift ~ 0.9, o uso deste método possibilitou a detecção de sete objetos candidatos a galáxias "early-type". Num mapa da distribuição projetada dos objetos para 22 < i' < 25 observou-se que estas galáxias estão localizadas próximas a um dos quasares e há indícios de que estejam aglomeradas dentro de um área de ~ 6 arcmin2. Se esse for o caso, estes objetos seriam membros de uma estrutura em grande escala. Um outro argumento em favor dessa hipótese é que eles obedecem uma relação do tipo Kormendy (raio equivalente X brilho superficial dentro desse raio), como a apresentada pelas galáxias elípticas em z = 0.

  8. [CENTRAL ANTICHOLINERGIC... SYNDROME?].

    PubMed

    Danilov, M S; Lebedinskii, K M

    2015-01-01

    While reading special literature in diferent languages the authors noted surprising fact: the term and concept of "central anticholinergic syndrome" is well-known as common anaesthesia complication in German (abbr: ZAS) and partially Spanish sources, but in Russian, English or French literature is used only in toxicological context. Describing etiology, pathogenesis, symptoms, diagnosis and treatment of the complication manifesting with comatose, agitated or shivering forms, the authors analyzing the reasons for such a noticeably diferent approaches to the situation reaching 10% of all the general anaesthesia cases. Probably, ZAS isn't nosologically clearly defined syndrome, but just adverse appearance of one of the fundamental general anaesthesia mechanisms? Anyway, the problem of central cholinergic activity suppression, excessive by its amplitude and/or duration, exists all over the world. German concept of ZAS allows the anaesthesiologist to resolve it on pathogenically generalized basis, while in other professional communities various symptomatic approaches seem to be more common.

  9. FNAL central email systems

    SciTech Connect

    Schmidt, Jack; Lilianstrom, Al; Pasetes, Ray; Hill, Kevin; /Fermilab

    2004-10-01

    The FNAL Email System is the primary point of entry for email destined for an employee or user at Fermilab. This centrally supported system is designed for reliability and availability. It uses multiple layers of protection to help ensure that: (1) SPAM messages are tagged properly; (2) All mail is inspected for viruses; and (3) Valid mail gets delivered. This system employs numerous redundant subsystems to accomplish these tasks.

  10. Fires in Central America

    NASA Technical Reports Server (NTRS)

    2002-01-01

    As can be seen in this true-color scene acquired on April 2, 2002, many fires dot the landscape across portions of Central America. This image spans from Mexico's Yucatan Peninsula across Guatemala and into El Salvador and Honduras. This image was acquired by the Moderate-resolution Imaging Spectroradiometer (MODIS), flying aboard NASA's Terra satellite. The red boxes indicate where active fires were burning.

  11. Central nervous system toxicity.

    PubMed

    Ruha, Anne-Michelle; Levine, Michael

    2014-02-01

    Central nervous system toxicity caused by xenobiotic exposure is a common reason for presentation to the emergency department. Sources of exposure may be medicinal, recreational, environmental, or occupational; the means of exposure may be intentional or unintended. Toxicity may manifest as altered thought content resulting in psychosis or confusion; may affect arousal, resulting in lethargy, stupor, or coma; or may affect both elements of consciousness. Seizures may also occur. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. [Central neurocytoma: case report].

    PubMed

    Bouaziz, M; Mansour, A; Feknous, S; Yassi, F; Smati, S; Belhouchet, S; Lankar, A

    2009-12-01

    In this study, we report one case of central neurocytoma treated in our department. It is a benign tumor of the lateral ventricles of the brain with neuronal differentiation. The clinical symptoms mainly consisted in intracranial hypertension syndrome. Immunohistochemical studies are necessary for the histopathological diagnosis. The treatment of choice is surgical. To guarantee good progression, complete ablation is necessary. The clinical progression, radiological aspects, treatment, histopathology, and postoperative progression will be discussed.

  13. [Centralization versus decentralization. Hematology].

    PubMed

    Borregaard, Niels

    2006-04-10

    Clinical haematology is the result of teamwork among dedicated specialists in pathology, molecular diagnostics, imaging, radiotherapy and the haematologist, who in turn can focus on only a limited fraction of the various and highly complex diseases that together constitute clinical haematology. The treatment of patients should be centralized in departments large enough to permit internal subspecialization and to provide expert service focused on haematology. No more than three such hematology centers are needed in Denmark.

  14. Centrality based Document Ranking

    DTIC Science & Technology

    2014-11-01

    approach. We model the documents to be ranked as nodes in a graph and place edges between documents based on their similarity. Given a query, we compute...similarity of the query with respect to every document in the graph . Based on these similarity values, documents are ranked for a given query...clinical documents using centrality based approach. We model the documents to be ranked as nodes in a graph and place edges between documents based on their

  15. [The central pattern generators].

    PubMed

    Balaban, P M; Vorontsov, D D; Dyakonova, V E; Dyakonova, T L; Zakharov, I S; Korshunova, T A; Orlov, O Yu; Pavlova, G A; Panchin, Yi V; Sakharov, D A; Falikman, M V

    2013-01-01

    The central pattern generator (CPG) is defined as a set of neurons involved in joint production of patterned motor output. The roundtable discussion on the CPG was a part of the 5th All-Russian Conference on Animal Behavior (Moscow, Nov. 21, 2012). The discussion centred on three core themes: 1) the mechanisms of the organization and reconfiguration of pattern generating neuronal ensembles, 2) extrapolations that extend the CPG concept beyond the motor systems, and 3) evolutionary and developmental aspects of CPG.

  16. Central corneal abscess.

    PubMed

    van Bijsterveld, O P

    1976-05-01

    Central corneal abscess developed in the experimental animal after inoculation of biologically active staphylococcal strains in a paracentral epithelial lesion of the cornea. These abscesses did not ulcerate, developed only with high inocula, occurred more frequently in immunized rabbits. A serpiginous type of ulceration did not develop at the site of the initial epithelial lesion nor at any other place in the cornea. Histologically, the lesions consisted of densely packed polymorphonuclear leukocytes between the corneal lamellae.

  17. Gangs in Central America

    DTIC Science & Technology

    2007-08-02

    564 ( Engel ) recognizing that violence poses an increasingly serious threat to peace and stability in Central America and supporting expanded...2005; UNODC, May 2007. 10 For example, see Federico Brevé, former Minister of Defense of Honduras, “The Maras: A Menace to the Americas,” Military...police training and judicial reform. On July 31, 2007, the House Committee on Foreign Affairs approved H.Res. 564 ( Engel ) recognizing that violence

  18. Gangs in Central America

    DTIC Science & Technology

    2008-10-17

    activity and in the handling of deported gang members. However, none of those bills were enacted. On October 2, 2007, the House passed H.Res. 564 ( Engel ...UNODC, May 2007. 12 For example, see Federico Brevé, former Minister of Defense of Honduras, “The Maras: A Menace to the Americas,” Military Review...passed H.Res. 564 ( Engel ) supporting expanded cooperation between the United States and Central America to combat crime and violence. Mérida

  19. Gangs in Central America

    DTIC Science & Technology

    2008-03-27

    handling of deported gang members, but none of those bills were enacted. On October 2, 2007, the House passed H.Res. 564 ( Engel ) supporting expanded...crimes committed CRS-4 12 For example, see Federico Brevé, former Minister of Defense of Honduras, “The Maras: A Menace to the Americas,” Military...examined the effects of U.S. deportations on Central America. On October 2, 2007, the House passed H.Res. 564 ( Engel ) supporting expanded

  20. [Central precocious puberty].

    PubMed

    Krysiak, Robert; Marek, Bogdan; Okopień, Bogusław

    2008-01-01

    Central precocious puberty, defined as the onset of puberty before the age 8 years in girls and 9 years in boys, results from a premature activation of gonadotropin-releasing hormone neurons in the hypothalamus. This condition is characterised by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. It may be either idiopathic or associated with hypothalamic hamartoma, brain neoplasms, numerous non-cancerous disorders of the central nervous system and treatment of peripheral precocious puberty. The goal of the initial assessment of children is to exclude the presence of all these organic disorders. The diagnosis should include detailed anamnesis and clinical examination, measurement of pituitary and sex hormones, assessment of bone age, and imaging of the hypothalamus, pituitary gland, abdomen, pelvis and gonads. The treatment of choice are gonadotropin-releasing hormone agonists. In this paper, we review the current views on the etiopathogenesis, clinical presentation, diagnosis and management of central precocious puberty.

  1. West and Central Africa.

    PubMed

    Lydie, N; Robinson, N J

    1998-01-01

    This article reviews scientific and other literature during the 1990s that links migration and mobility with the spread of sexually transmitted diseases (STDs), including HIV/AIDS. The focus is on key population groups linked to the spread of HIV and STDs in West and Central Africa: migrant laborers, truck drivers, itinerant traders, commercial sex workers (CSWs), and refugees. Countries with high emigration and immigration tend to have high levels of HIV infection, with the exception of Senegal. The main destination of immigrants are Senegal, Nigeria, and Cote d'Ivoire in West Africa and Cameroon, Congo, Gabon, and Congo in Central Africa. The risk of infection and the spread of HIV is variable among migrants. There is little in the literature that substantiates hypotheses about the strong association between migration and HIV-positive status. Information is needed on the duration, frequency of return visits, living conditions, sexual activities with multiple partners, and information before departure, along the routes, at final destination, and at the time of returns. Action-based research in five West African countries (Burkina Faso, Cote d'Ivoire, Mali, Niger, and Senegal) should produce results in late 1998. Comparable studies in Central Africa are unknown. Regional studies should be complemented by local studies. Prevention would benefit from studies on the relative size of these five population groups by geographic location.

  2. Central effects of fingolimod.

    PubMed

    Cruz, Vítor T; Fonseca, Joaquim

    2014-08-01

    Introduccion. El fingolimod, un modulador del receptor de la esfingosina-1-fosfato (S1P) dotado de un mecanismo de accion novedoso, fue el primer tratamiento oral aprobado para la esclerosis multiple remitente recurrente. Su union a los receptores S1P1 de los linfocitos promueve la retencion selectiva de los linfocitos T virgenes y de memoria central en los tejidos linfoides secundarios, lo que impide su salida hacia el sistema nervioso central (SNC). Asimismo, el fingolimod atraviesa con facilidad la barrera hematoencefalica, y diversos estudios le atribuyen un efecto neuroprotector directo en el SNC. Objetivo. Revisar la informacion disponible acerca de los efectos centrales del fingolimod. Desarrollo. El desequilibrio entre los procesos lesivos y reparadores constituye un reflejo de la desmielinizacion cronica, la degeneracion axonal y la gliosis, y parece contribuir a la discapacidad que la esclerosis multiple acarrea. La facilidad con la que el fingolimod atraviesa la barrera hematoencefalica le permite actuar directamente sobre los receptores S1P localizados en las celulas del SNC. Una vez en el interior del SNC, ocupa los receptores S1P de los oligodendrocitos y de sus celulas precursoras, de los astrocitos, los microgliocitos y las neuronas, fomentando la remielinizacion, la neuroproteccion y los procesos endogenos de regeneracion. La eficacia evidenciada en los ensayos clinicos concuerda con un mecanismo de accion que incluiria efectos directos sobre las celulas del SNC. Conclusiones. Los datos disponibles indican que la eficacia del fingolimod en el tratamiento de la esclerosis multiple se debe a su ambivalencia como molecula inmunomoduladora y moduladora directa de los receptores S1P del SNC. Tanto es asi que estudios recientes le atribuyen efectos neuroprotectores en varios modelos que suscitan expectativas en torno a su posible aplicacion terapeutica en la enfermedad de Alzheimer, el paludismo cerebral y el neuroblastoma, asi como en la neuroproteccion

  3. Central American resource studies

    SciTech Connect

    Van Eeckhout, E.; Laughlin, A.W.

    1989-01-01

    Los Alamos National Laboratory has been working with five Central American countries to assist in the development of their energy and mineral resources. Since 1985, mineral resources in Costa Rica, peat resources in Costa Rica and Panama, geothermal energy resources in Honduras and Guatemala, and geothermal field development in El Salvador and Costa Rica have been topics of study. This paper presents an overview of this work -- within these proceedings are papers that deal with specific aspects of each topic, and these will be duly noted. 15 refs., 4 figs.

  4. Fires in Central America

    NASA Technical Reports Server (NTRS)

    2002-01-01

    As can be seen in this true-color scene acquired on April 2, 2002, many fires dot the landscape across portions of Central America. This image spans from Mexico's Yucatan Peninsula across Guatemala and into El Salvador and Honduras. This image was acquired by the Moderate-resolution Imaging Spectroradiometer (MODIS), flying aboard NASA's Terra satellite. The red boxes (click on the image above to see it at 250-meter resolution) indicate where active fires were burning. Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC

  5. Fires in Central Africa

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Hundreds of fires are set every year during the dry season in Central Africa. This true color image from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) shows dozens of smoke plumes in the Democratic Republic of the Congo on June 29, 2000. Residents burn away scrub and brush annually in the woody savanna to clear land for farming and grazing. For more information, visit the SeaWiFS Home Page, Global Fire Monitoring Fact Sheet, and 4km2 Fire Data Image Provided by the SeaWiFS Project, NASA/Goddard Space Flight Center, and ORBIMAGE

  6. Flooding in Central Siberia

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A mixture of snowmelt and ice jams in late May and June of this year caused the Taz River (left) and the Yenisey River (right) in central Siberia to overflow their banks. The flooding can be seen in this image taken on June 11, 2002, by the MODIS (Moderate Resolution Imaging Spectroradiometer) instrument aboard the Terra satellite. Normally, the rivers would resemble thin black lines in MODIS imagery. In the false-color images sage green and rusty orange is land, and water is black. Clouds are white and pink. Credit: Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC

  7. Floods in Central China

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This pair of true- and false-color images from the Moderate resolution Imaging Spectroradiometer (MODIS) shows flooding in central China on July 4, 2002. In the false-color image vegetation appears orange and water appears dark blue to black. Because of the cloud cover and the fact that some of the water is filled with sediment, the false-color image provides a clearer picture of where rivers have exceeded their banks and lakes have risen. The river in this image is the Yangtze River, and the large lake is the Poyang Hu. Credits: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

  8. Flooding in Central Siberia

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A mixture of snowmelt and ice jams in late May and June of this year caused the Taz River (left) and the Yenisey River (right) in central Siberia to overflow their banks. The flooding can be seen in this image taken on June 11, 2002, by the MODIS (Moderate Resolution Imaging Spectroradiometer) instrument aboard the Terra satellite. Normally, the rivers would resemble thin black lines in MODIS imagery. In the false-color images sage green and rusty orange is land, and water is black. Clouds are white and pink. Credit: Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC

  9. Central Campus Construction Progress

    NASA Image and Video Library

    2016-10-18

    A large crane towers overhead as the new, seven-story headquarters building takes shape in the industrial area at NASA’s Kennedy Space Center in Florida. The 200,000-square-foot facility will anchor the spaceport’s Central Campus and house about 500 NASA civil service and contractor employees. The building will be more energy efficient than the current Headquarters building and will feature the latest in office and administrative building technology to fulfill Kennedy's role as the premiere multi-user spaceport for NASA and, increasingly, commercial entities.

  10. Floods in Central China

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This pair of true- and false-color images from the Moderate resolution Imaging Spectroradiometer (MODIS) shows flooding in central China on July 4, 2002. In the false-color image vegetation appears orange and water appears dark blue to black. Because of the cloud cover and the fact that some of the water is filled with sediment, the false-color image provides a clearer picture of where rivers have exceeded their banks and lakes have risen. The river in this image is the Yangtze River, and the large lake is the Poyang Hu. Credits: Jacques Descloitres, MODIS Land Rapid Response Team, NASA/GSFC

  11. Fires in Central Africa

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Hundreds of fires are set every year during the dry season in Central Africa. This true color image from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) shows dozens of smoke plumes in the Democratic Republic of the Congo on June 29, 2000. Residents burn away scrub and brush annually in the woody savanna to clear land for farming and grazing. For more information, visit the SeaWiFS Home Page, Global Fire Monitoring Fact Sheet, and 4km2 Fire Data Image Provided by the SeaWiFS Project, NASA/Goddard Space Flight Center, and ORBIMAGE

  12. Central Campus Construction Progress

    NASA Image and Video Library

    2016-10-18

    The new headquarters building’s seven floors are clearly visible as construction continues in the industrial area at NASA’s Kennedy Space Center in Florida. The 200,000-square-foot facility will anchor the spaceport’s Central Campus and house about 500 NASA civil service and contractor employees. The building will be more energy efficient than the current Headquarters building and will feature the latest in office and administrative building technology to fulfill Kennedy's role as the premiere multi-user spaceport for NASA and, increasingly, commercial entities.

  13. Central Vision in the Newborn.

    ERIC Educational Resources Information Center

    Lewis, Terri L.; Maurer, Daphne

    1980-01-01

    Tests newborns' ability to detect a dot with central vision and compares both the proportion of time the infants fixated centrally and the duration of each central fixation. Subjects were 46 newborns ranging in age from 1 to 7 days. (MP)

  14. Feature Centrality and Property Induction

    ERIC Educational Resources Information Center

    Hadjichristidis, Constantinos; Sloman, Steven; Stevenson, Rosemary; Over, David

    2004-01-01

    A feature is central to a concept to the extent that other features depend on it. Four studies tested the hypothesis that people will project a feature from a base concept to a target concept to the extent that they believe the feature is central to the two concepts. This centrality hypothesis implies that feature projection is guided by a…

  15. Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets.

    PubMed

    Willinger, Tim; Freeman, Tom; Hasegawa, Hitoshi; McMichael, Andrew J; Callan, Margaret F C

    2005-11-01

    Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (T(CM)), effector memory (T(EM)), and effector memory RA (T(EMRA)) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry. We demonstrate that T(CM) have a gene expression and cytokine signaling signature that lies between that of naive and T(EM) or T(EMRA) cells, whereas T(EM) and T(EMRA) are closely related. Our data define the molecular basis for the different functional properties of central and effector memory subsets. We show that T(EM) and T(EMRA) cells strongly express genes with known importance in CD8 T cell effector function. In contrast, T(CM) are characterized by high basal and cytokine-induced STAT5 phosphorylation, reflecting their capacity for self-renewal. Altogether, our results distinguish T(CM) and T(EM)/T(EMRA) at the molecular level and are consistent with the concept that T(CM) represent memory stem cells.

  16. Central diabetes insipidus.

    PubMed

    Arima, Hiroshi; Azuma, Yoshinori; Morishita, Yoshiaki; Hagiwara, Daisuke

    2016-12-01

    Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause of idiopathic CDI. Among secondary CDI, the tumors in the central nervous system such as craniopharyngioma and germ cell tumors are the most frequent causes. Familial CDI is inherited mostly in an autosomal dominant mode, and the number of causal mutations in the AVP gene locus reported so far exceeds 80. CDI is treated with desmopressin, an analogue of vasopressin, and the tablet is preferred to the nasal form because it is easier to administer. It is also shown that the oral disintegrating tablet formula increases QOL and decreases the incidence of hyponatremia in CDI patients. In some CDI patients, the osmoreceptors in the hypothalamus do not function and patients do not sense thirst. These adipsic CDI patients are treated with desmopressin and adjusting the amount of daily water intake based on body weight measurement; but controlling the water balance is extremely difficult, and morbidity and mortality are shown to be high in these patients.

  17. Central diabetes insipidus

    PubMed Central

    Arima, Hiroshi; Azuma, Yoshinori; Morishita, Yoshiaki; Hagiwara, Daisuke

    2016-01-01

    ABSTRACT Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause of idiopathic CDI. Among secondary CDI, the tumors in the central nervous system such as craniopharyngioma and germ cell tumors are the most frequent causes. Familial CDI is inherited mostly in an autosomal dominant mode, and the number of causal mutations in the AVP gene locus reported so far exceeds 80. CDI is treated with desmopressin, an analogue of vasopressin, and the tablet is preferred to the nasal form because it is easier to administer. It is also shown that the oral disintegrating tablet formula increases QOL and decreases the incidence of hyponatremia in CDI patients. In some CDI patients, the osmoreceptors in the hypothalamus do not function and patients do not sense thirst. These adipsic CDI patients are treated with desmopressin and adjusting the amount of daily water intake based on body weight measurement; but controlling the water balance is extremely difficult, and morbidity and mortality are shown to be high in these patients. PMID:28008190

  18. The European Mobile System (EMS)

    NASA Technical Reports Server (NTRS)

    Jongejans, A.; Rogard, R.; Mistretta, I.; Ananasso, F.

    1993-01-01

    The European Space Agency is presently procuring an L band payload in order to promote a regional European L band system coping with the specific needs of the European market. The payload, and the two communications systems to be supported, are described below. The potential market for EMS in Europe is discussed.

  19. DOE EM industry programs robotics development

    SciTech Connect

    Staubly, R.; Kothari, V.

    1998-12-31

    The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy`s (DOE`s) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution.

  20. Future Flight Central

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA 'Future Flight Central,' the world's first full-scale virtual airport control tower, opened December 13, 1999 at NASA Ames Research Center, Moffett Field, California. Constructed at a cost of $10 million, the two story facility was jointly funded by NASA and the Federal Aviation Administration (FAA). The facility is designed to test ways to solve potential air and ground traffic problems at commercial airports under realistic airport conditions and configurations. The facility provides an opportunity for airlines and airports to mitigate passenger delays by fine tuning airport hub operations, gate management, ramp movement procedures, and various other airport improvements. Twelve rear projection screens provide a seamless 360 degree high- resolution view of the airport or other screens being depicted. The imaging system, powered by supercomputers, provides a realistic view of weather conditions, enviromental and seasonal effects and the movement of up to 200 active aircraft and ground vehicles.

  1. Flooding in Central China

    NASA Technical Reports Server (NTRS)

    2002-01-01

    During the summer of 2002, frequent, heavy rains gave rise to floods and landslides throughout China that have killed over 1,000 people and affected millions. This false-color image of the western Yangtze River and Dongting Lake in central China was acquired on August 21, 2002, by the Moderate-resolution Imaging Spectroradiometer (MODIS), flying aboard NASA's Terra spacecraft. (right) The latest flooding crisis in China centers on Dingtong Lake in the center of the image. Heavy rains have caused it to swell over its banks and swamp lakefront towns in the province of Hunan. As of August 23, 2002, more than 250,000 people have been evacuated, and over one million people have been brought in to fortify the dikes around the lake. Normally the lake would appear much smaller and more defined in the MODIS image. Credit: Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC.

  2. Central solar energy receiver

    DOEpatents

    Drost, M. Kevin

    1983-01-01

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  3. Familial central serous retinopathy.

    PubMed

    Oosterhuis, J A

    1996-05-01

    To study the familial occurrence of central serous retinopathy (CSR). We pooled data from eight eye clinics in Western Europe. We collected 11 families that each had two to four members with CSR. In 10 families siblings and in one family a mother and son were affected. Sixty percent of the patients were male and 40% female. CSR was found in 55 (92%) of 60 eyes, 44 (80%) showing a chronic course. In 25 patients (83%) both eyes were affected. Most recent visual acuity was 0.5 or less in 17 (39%) and 0.2 or less in 8 (18%) of the eyes with chronic CSR. Our findings of familial occurrence and a chronic disorder that is progressive, diffuse, and bilateral suggest an inborn disposition to develop a clinically manifest disintegration of the retinal pigment epithelium in adulthood.

  4. Central Campus Construction Progress

    NASA Image and Video Library

    2017-03-17

    NASA's Kennedy Space Center in Florida is a premier, multi-user spaceport with ongoing construction adding new, ultra-modern facilities. A key element of the Central Campus makeover is a new, seven-story, 200,000-square-foot headquarters building that has taken shape in the heart of the spaceport. The headquarters building's glass facade, as seen from NASA Causeway, is complete. The exterior skin of the building also is nearly finished. The remainder of the glass components are being installed on each floor. Construction of interior walls and utilities on most floors is well underway. Construction of the headquarters building is targeted for completion in November 2017 and employees are expected to be able to move in soon after.

  5. Flooding in Central China

    NASA Technical Reports Server (NTRS)

    2002-01-01

    During the summer of 2002, frequent, heavy rains gave rise to floods and landslides throughout China that have killed over 1,000 people and affected millions. This false-color image of the western Yangtze River and Dongting Lake in central China was acquired on August 21, 2002, by the Moderate-resolution Imaging Spectroradiometer (MODIS), flying aboard NASA's Terra spacecraft. (right) The latest flooding crisis in China centers on Dingtong Lake in the center of the image. Heavy rains have caused it to swell over its banks and swamp lakefront towns in the province of Hunan. As of August 23, 2002, more than 250,000 people have been evacuated, and over one million people have been brought in to fortify the dikes around the lake. Normally the lake would appear much smaller and more defined in the MODIS image. Credit: Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC.

  6. Haze in central China

    NASA Image and Video Library

    2017-09-27

    The Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA’s Terra satellite acquired this natural-color image of central China on January 23, 2013 at 04:05 UTC. The image shows extensive haze over the region. In areas where the ground is visible, some of the landscape is covered with lingering snow. Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  7. Central pit craters on Ganymede

    NASA Astrophysics Data System (ADS)

    Alzate, Nathalia; Barlow, Nadine G.

    2011-02-01

    Central pit craters are common on Mars, Ganymede and Callisto, and thus are generally believed to require target volatiles in their formation. The purpose of this study is to identify the environmental conditions under which central pit craters form on Ganymede. We have conducted a study of 471 central pit craters with diameters between 5 and 150 km on Ganymede and compared the results to 1604 central pit craters on Mars (diameter range 5-160 km). Both floor and summit pits occur on Mars whereas floor pits dominate on Ganymede. Central peak craters are found in similar locations and diameter ranges as central pit craters on Mars and overlap in location and at diameters <60 km on Ganymede. Central pit craters show no regional variations on either Ganymede or Mars and are not concentrated on specific geologic units. Central pit craters show a range of preservation states, indicating that conditions favoring central pit formation have existed since crater-retaining surfaces have existed on Ganymede and Mars. Central pit craters on Ganymede are generally about three times larger than those on Mars, probably due to gravity scaling although target characteristics and resolution also may play a role. Central pits tend to be larger relative to their parent crater on Ganymede than on Mars, probably because of Ganymede's purer ice crust. A transition to different characteristics occurs in Ganymede's icy crust at depths of 4-7 km based on the larger pit-to-crater-diameter relationship for craters in the 70-130-km-diameter range and lack of central peaks in craters larger than 60-km-diameter. We use our results to constrain the proposed formation models for central pits on these two bodies. Our results are most consistent with the melt-drainage model for central pit formation.

  8. Cosmic muon induced EM showers in NO$\

    SciTech Connect

    Yadav, Nitin; Duyang, Hongyue; Shanahan, Peter; Mishra, Sanjib; Bhuyan, Bipul

    2016-11-15

    Here, the NuMI Off-Axis ve Appearance (NOvA) experiment is a ne appearance neutrino oscillation experiment at Fermilab. It identifies the ne signal from the electromagnetic (EM) showers induced by the electrons in the final state of neutrino interactions. Cosmic muon induced EM showers, dominated by bremsstrahlung, are abundant in NOvA far detector. We use the Cosmic Muon- Removal technique to get pure EM shower sample from bremsstrahlung muons in data. We also use Cosmic muon decay in flight EM showers which are highly pure EM showers.The large Cosmic-EM sample can be used, as data driven method, to characterize the EM shower signature and provides valuable checks of the simulation, reconstruction, particle identification algorithm, and calibration across the NOvA detector.

  9. Central America's shrinking forests.

    PubMed

    1992-01-01

    This news brief reports that 66% of deforestation in Central America has happened in the past 40 years, based on World Conservation Union (WCU) data. Deforestation is expected to continue. The population of Central America and Mexico grew by 28% between 1977 and 1987. Growth is decreasing but remains high at 2.5% in all countries of the region except Panama. 29 million was the regional population in 1990; the projection is for 63 million by 2025. Population is migrating to urban centers. Forests declined by 13% and croplands increased from 4% to 13% of total land area and pasture land from 2% to 37%. There was an increase in unproductive land from 145 to 24%, i.e., 50% of El Salvador's land had soil degradation as does 30% of Guatemala's. In addition to deforestation and soil degradation, there has been soil erosion leading to sedimentation buildup near dam sites and in rivers, which diminishes hydroelectric power capability. Silting also affects groundwater resources, which impact on a safe drinking water supply. Population growth results in increased demand for fuelwood, urban land, and agricultural land. New techniques practiced widely are needed in order to meet the region's needs or demands. Slowing population growth buys time for adjusting to the necessary changes needed for sustaining the region's population. WCU urges conservation organizations to raise awareness about the role population plays in environmental degradation, and to support efforts to reduce birth rates. Women's status needs to be improved through income-generating projects, for instance, and cooperation is needed between conservation groups and organizations involved with improving maternal and child health.

  10. Correlation of the NBME advanced clinical examination in EM and the national EM M4 exams.

    PubMed

    Hiller, Katherine; Miller, Emily S; Lawson, Luan; Wald, David; Beeson, Michael; Heitz, Corey; Morrissey, Thomas; House, Joseph; Poznanski, Stacey

    2015-01-01

    Since 2011 two online, validated exams for fourth-year emergency medicine (EM) students have been available (National EM M4 Exams). In 2013 the National Board of Medical Examiners offered the Advanced Clinical Examination in Emergency Medicine (EM-ACE). All of these exams are now in widespread use; however, there are no data on how they correlate. This study evaluated the correlation between the EM-ACE exam and the National EM M4 Exams. From May 2013 to April 2014 the EM-ACE and one version of the EM M4 exam were administered sequentially to fourth-year EM students at five U.S. medical schools. Data collected included institution, gross and scaled scores and version of the EM M4 exam. We performed Pearson's correlation and random effects linear regression. 305 students took the EM-ACE and versions 1 (V1) or 2 (V2) of the EM M4 exams (281 and 24, respectively) [corrected].The mean percent correct for the exams were as follows: EM-ACE 74.9 (SD-9.82), V1 83.0 (SD-6.39), V2 78.5 (SD-7.70) [corrected]. Pearson's correlation coefficient for the V1/EM-ACE was 0.53 (0.43 scaled) and for the V2/EM-ACE was 0.58 (0.41 scaled) [corrected]. The coefficient of determination for V1/ EM-ACE was 0.73 and for V2/EM-ACE 0.71 (0.65 and .49 for scaled scores) [ERRATUM]. The R-squared values were 0.28 and 0.30 (0.18 and 0.13 scaled), respectively [corrected]. There was significant cluster effect by institution. There was moderate positive correlation of student scores on the EM-ACE exam and the National EM M4 Exams.

  11. [MANAGEMENT OF CENTRAL HYPERSOMNIAS].

    PubMed

    Dauvilliers, Yves; Lopez, Régis

    2016-06-01

    Central hypersomnias include narcolepsy type 1, type 2 and idiopathic hypersomnia with daytime sleepiness excessive in the foreground of the clinical symptoms. Despite major advances in our understanding of the mechanisms of the narcolepsy type 1 with a low level of hypocretin-1 in cerebrospinal fluid, its current management is only symptomatic. The current management is also only symptomatic for type 2 narcolepsy and idiopathic hypersomnia with an unknown pathophysiology. Treatment options may vary from a single drug targeting several symptoms or several drugs treating a specific symptom. The treatment of daytime sleepiness is based on modafinil in first intention. Other psychostimulants such as methylphenidate, pitolisant and exceptionally dextro-amfetamine may be considered. In narcolepsy type 1, antidepressants such as inhibitors of the reuptake of serotonin and noradrenaline will be considered to improve cataplexy. Sodium oxybate is an effective treatment on sleepiness, cataplexy and bad night sleep in narcolepsy. The management for other symptoms or comorbidities should be considered it necessary such as hallucinations, sleep paralysis, the disturbed nighttime sleep, unpleasant dreams, parasomnias, depressive symptoms, overweight/obesity, cardiovascular disease and obstructive sleep apnea syndrome. Important therapeutic perspectives are to be expected concerning new psychostimulant and anticataplectiques, but mainly on immune-based therapies administered as early as possible after disease onset and on hypocretin replacement therapy for patients with severe symptoms.

  12. Mexico and Central America.

    PubMed

    Bronfman, M

    1998-01-01

    This article reviews the literature on migration and HIV/AIDS in Mexico and Central America, including Belize, Costa Rica, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, and Panama. Most migrants travel to the US through Mexico. US-Mexico trade agreements created opportunities for increased risk of HIV transmission. The research literature focuses on Mexico. Most countries, with the exception of Belize and Costa Rica, are sending countries. Human rights of migrants are violated in transit and at destination. Migration policies determine migration processes. The Mexican-born population in the US is about 3% of US population and 8% of Mexico's population. About 22% arrived during 1992-97, and about 500,000 are naturalized US citizens. An additional 11 million have a Mexican ethnic background. Mexican migrants are usually economically active men who had jobs before leaving and were urban people who settled in California, Texas, Illinois, and Arizona. Most Mexican migrants enter illegally. Many return to Mexico. The main paths of HIV transmission are homosexual, heterosexual, and IV-drug-injecting persons. Latino migrants frequently use prostitutes, adopt new sexual practices including anal penetration among men, greater diversity of sexual partners, and use of injectable drugs.

  13. Central Disorders of Hypersomnolence

    PubMed Central

    Khan, Zeeshan

    2015-01-01

    The central disorders of hypersomnolence are characterized by severe daytime sleepiness, which is present despite normal quality and timing of nocturnal sleep. Recent reclassification distinguishes three main subtypes: narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia (IH), which are the focus of this review. Narcolepsy type 1 results from loss of hypothalamic hypocretin neurons, while the pathophysiology underlying narcolepsy type 2 and IH remains to be fully elucidated. Treatment of all three disorders focuses on the management of sleepiness, with additional treatment of cataplexy in those patients with narcolepsy type 1. Sleepiness can be treated with modafinil/armodafinil or sympathomimetic CNS stimulants, which have been shown to be beneficial in randomized controlled trials of narcolepsy and, quite recently, IH. In those patients with narcolepsy type 1, sodium oxybate is effective for the treatment of both sleepiness and cataplexy. Despite these treatments, there remains a subset of hypersomnolent patients with persistent sleepiness, in whom alternate therapies are needed. Emerging treatments for sleepiness include histamine H3 antagonists (eg, pitolisant) and possibly negative allosteric modulators of the gamma-aminobutyric acid-A receptor (eg, clarithromycin and flumazenil). PMID:26149554

  14. Central nervous system stimulants.

    PubMed

    George, A J

    2000-03-01

    Three major types of CNS stimulant are currently abused in sport: amphetamine, cocaine and caffeine. Each drug type has its own characteristic mechanism of action on CNS neurones and their associated receptors and nerve terminals. Amphetamine is widely abused in sports requiring intense anaerobic exercise where it prolongs the tolerance to anaerobic metabolism. It is addictive, and chronic abuse causes marked behavioural change and sometimes psychosis. Major sports abusing amphetamine are cycling, American football, ice-hockey and baseball. Cocaine increases tolerance to intense exercise, yet most of its chronic effects on energy metabolism are negative. Its greatest effects seem to be as a central stimulant and the enhancement of short-term anaerobic exercise. It is highly addictive and can cause cerebral and cardiovascular fatalities. Caffeine enhances fatty acid metabolism leading to glucose conservation, which appears to benefit long-distance endurance events such as skiing. Caffeine is also addictive, and chronic abuse can lead to cardiac damage. Social abuse of each of the three drugs is often difficult to distinguish from their abuse in sport.

  15. [Central infantile hypotonia syndrome].

    PubMed

    Lesný, I; Prosková, M; Lehovský, M

    1989-04-14

    Czechoslovak child neurologists devoted much attention to central infantile hypotonic syndrome (CIHS) in a series of investigations conducted in 1959-1986. They found that it is a developmental syndrome caused by affection of the immature brain, and later, at the age of 3-5 years, it disappears or transforms into other syndromes: most frequently cerebellar syndromes and developmental disintegrations (disintegration of the development of the CNS and medium-grade mental retardation). These groups overlap only little. From the hypotonic syndrome also the spastic syndrome or minor cerebral syndromes may develop. CIHS has, similarly as some other manifestations of CNS affections, multiple causes. One of them is most probably a defect of or lack of development of facilitating pathways of gamma fibres from the cerebellum or possibly from the reticular formation of the brain stem to the spinal cord; another probable cause is longer immaturity of the afferent system (which leads finally to developmental disintegration). It may be assumed that the facilitating systems of pathways develop later and are thus more immature and therefore more vulnerable. According to the latest information it seems that in CIHS also the muscular component participates as prenatal cerebral affections can cause myopathy with hypotonia.

  16. Complaints against an EMS system.

    PubMed

    Colwell, Christopher B; Pons, Peter T; Pi, Randy

    2003-11-01

    Complaints against Emergency Medical Services (EMS) agencies represent a concerning and potentially time-consuming problem for all involved in the delivery of prehospital emergency medical care. The objective of this study was to identify the source of complaints against an EMS system to help focus quality and performance improvement and customer service efforts. We conducted a retrospective review of complaints filed against a busy urban EMS agency over a 6-year period. All complaints were included, totaled by season and by year, and categorized by originator and nature of the complaint. A total of 286 complaints were registered during the 6-year period, with an average of 48 per year and 9.3 per 10,000 responses. The most common originators of complaints were patients (53%) followed by medical personnel (19%) and family members or friends (12%). Rude behavior accounted for 23% of the complaints registered, followed by technical skills (20%), transport problems (18%), and loss of belongings (13%). The identification of areas of dissatisfaction will allow focused quality and performance improvement programs directed at customer service and risk management.

  17. Central African Republic.

    PubMed

    1989-11-01

    The Central African Republic contains 242,000 square miles, which rolling terrain almost 2000 feet above sea level. The climate is tropical, and it has a population of 2.8 million people with a 2.5% growth rate. There are more than 80 ethnic groups including Baya 34%, Banda 28%, Sara 10%, Mandja 9%, Mboum 9%, and M'Baka 7%. The religions are traditional African 35%, protestant 25%, Roman Catholic 25%, and Muslim 15%, and the languages are French and Sangho. The infant mortality rate is 143/1000, with expectancy at 49 years and a 40% literacy rate. The work force of 1 million is 70% agricultural, industry 6% and commerce and service 6% and government 3%. The government consists of a president assisted by cabinet ministers and a single party. Natural resources include diamonds, uranium, timber, gold, and oil, and major industries are beverages, textiles, and soap. Agricultural products feature coffee, cotton, peanuts, tobacco, food crops and livestock. Most of the population live in rural areas and most of the 80 ethnic groups have their own language. This is one of the world's least developed countries, with a per capita income of $375/year. The main problems with development are the poor transportation infrastructure, and the weak internal and international marketing systems. The US and various international organizations have aided in agriculture development, health programs, and family planning. US investment is mainly in diamond and gold mining, and although oil drilling has been successful it is not economically feasible at current prices.

  18. Recurrent central neurocytomas.

    PubMed

    Bertalanffy, Alexander; Roessler, Karl; Koperek, Oskar; Gelpi, Ellen; Prayer, Daniela; Knosp, Engelbert

    2005-07-01

    Since the first description of Central neurocytomas (CNs) as a benign tumor entity in 1982, there has been great enthusiasm regarding the benign course and the curative surgical approach to this disease. The current study was performed to investigate the frequency of disease recurrence during long-term follow-up. A retrospective analysis of the medical files with emphasis on clinicoradiologic findings and histologic and immunohistochemical features was performed. Between 1985-2003. surgical resection was performed in 14 patients with CNs ages 16-43 years (7 were female and 7 were male). Two patients (14%) died postoperatively and one patient had a malignant disease course (7%). In the remaining 11 patients, one patient with an incompletely resected CN had disease progression after 37 months but at the time of last follow-up had had stable disease for 10 years. In addition, the authors reported 5 patients with disease recurrence occurring at a median of 67 months after surgery (range, 51-79 months after surgery), all of which occurred after complete surgical resection was performed. The observation period for the remaining 5 patients was short (median of 34 months [range, 5-44 months]). Extensive histologic and immunohistochemical workup did not identify any significant prognostic parameters. The MIB-1 proliferation index ranged from 0.8-11% (median of 4.6%), but was reported to be 46.8% in the malignant transformed tumor. All patients with disease recurrence responded well to different forms of focal radiation therapy (gamma knife radiosurgery in three patients and interstitial irradiation in one patient) and for one patient with a recently detected recurrence, gamma knife radiosurgery was planned. CNs appear to have a higher tendency to recur during long-term follow-up than previously reported, even after complete resection. Therefore, periodic neuroradiologic follow-up examinations should be considered mandatory in all patients, even after several years.

  19. Central and southern Africa

    SciTech Connect

    McGrew, H.J.

    1981-10-01

    Exploration in central and southern Africa continued to expand during 1980. The greatest concentration of activity was in Nigeria. However, there was considerable increase in the level of exploratory work in Cameroon and Congo. Significant new finds have been made in Ivory Coast. Geological and geophysical activity was carried out in 18 of the countries, with those in the western part having the largest share. Seismic work involved 225 party months of operation. Most of this time was spent on land, but marine operations accounted for 73,389 km of new control. Gravity and magnetic data were recorded during the marine surveys, and several large aeromagnetic projects were undertaken to obtain a total of 164,498 line km of data. Exploratory and development drilling accounted for a total of 304 wells and 2,605,044 ft (794,212 m) of hole. The 92 exploratory wells that were drilled resulted in 47 oil and gas discoveries. In development drilling 89% of the 212 wells were successful. At the end of the year, 27 exploratory wells were underway, and 34 development wells were being drilled for a total of 61. Oil production from the countries that this review covers was 918,747,009 bbl in 1980, a drop of about 9% from the previous year. Countries showing a decline in production were Nigeria, Gabon, Cabinda, and Zaire. Increases were recorded in Cameroon, Congo, and Ghana. A new country was added to the list of producers when production from the Belier field in Ivory Coast came on stream. 33 figures, 15 tables.

  20. Cosmic muon induced EM showers in NO$$\

    DOE PAGES

    Yadav, Nitin; Duyang, Hongyue; Shanahan, Peter; ...

    2016-11-15

    Here, the NuMI Off-Axis ve Appearance (NOvA) experiment is a ne appearance neutrino oscillation experiment at Fermilab. It identifies the ne signal from the electromagnetic (EM) showers induced by the electrons in the final state of neutrino interactions. Cosmic muon induced EM showers, dominated by bremsstrahlung, are abundant in NOvA far detector. We use the Cosmic Muon- Removal technique to get pure EM shower sample from bremsstrahlung muons in data. We also use Cosmic muon decay in flight EM showers which are highly pure EM showers.The large Cosmic-EM sample can be used, as data driven method, to characterize the EMmore » shower signature and provides valuable checks of the simulation, reconstruction, particle identification algorithm, and calibration across the NOvA detector.« less

  1. Recursion Formulas of Central Configurations.

    NASA Astrophysics Data System (ADS)

    Tien, Fangcheng

    1993-01-01

    This paper analyzes central configurations which are special configurations leading to homothetic solutions of the n-body problem. For the planar central configurations, these solutions also provide periodic solutions of the n-body problem. Chapter 1 defines the problem and provides an overview of the area. There is historical interest in knowing the total number of these central configurations. For n >= 4 the problem remains unsolved. Furthermore, a different mass ratio between the n bodies will produce a different total number of central configurations. This paper will provide the total number of central configurations which has a special mass ratio. For the planar central configurations the total number of central configurations grows at the speed n!2n, and the three dimensional case is n!3^{n }. Chapters 2, 3 and 5 give details and proofs of the analytical continuation method. This method begins with three bodies, then creates the central configurations with four bodies with one small mass, using the implicit function theorem. If the process is repeated, the total number of central configurations for any n-body problem may be calculated, provided (n-3) masses are sufficiently small. In Chapters 4 and 7, the formulas are derived for the total number of central configurations of the n-body problem with special mass ratio (m _1,m_2,m_3,epsilon_1, ...,epsilonn) in both planar and three-dimensional cases. Examples of formulas provided are: n!(2^{n+1} + 1) , n!((n^2 - n + 4)2^{n+1 } - n - 7), and (n!/6) ((n ^3 + 11n - 12)2^{n+2} + 6n + 54). Chapter 6 solves a very special degenerate case during the continuation process. The Morse Index of these central configurations is discussed in Chapter 8.

  2. The Empathic Operating System (emOS)

    DTIC Science & Technology

    2016-06-15

    The Empathic Operating System ( emOS ) Physiological measurements have typically been limited to expensive and cumbersome clinical research equipment...Report: The Empathic Operating System ( emOS ) Report Title Physiological measurements have typically been limited to expensive and cumbersome clinical...C-0043 Proposal number: 62850-LS-DRP Project title: “The Empathic Operating System ( emOS )” Contract performance period: January 1, 2016 – April 7

  3. Testing Central and Inner Asian admixture among contemporary Hungarians.

    PubMed

    Bíró, András; Fehér, Tibor; Bárány, Gusztáv; Pamjav, Horolma

    2015-03-01

    Historically, the Carpathian Basin was the final destination for many nomadic peoples who migrated westward from Inner and Central Asia towards Europe. Proto-Hungarians (Steppe Magyars) were among those who came from the East, the Eurasian Steppe in the early middle ages. In order to detect the paternal genetic contribution from nomadic Steppe tribes, we tested 966 samples from Central Asian (Uzbekistan, Kazakhstan), Inner Asian (Mongolians and Buryats in Mongolia) and Hungarian-speaking European (Hungarian, Sekler and Csango) populations. We constructed median-joining networks of certain haplogroups in Hungarian-speaking European, and Altaic-speaking Central and Inner Asian populations. We estimated that the possible paternal genetic contribution from the above described populations among contemporary Hungarian speaking populations ranged between 5% and 7.4%. It is lowest among Hungarians from Hungary (5.1%), while higher among Hungarian-speaking groups in Romania, notably Sekler (7.4%) and Csango (6.3%). However, these results represent only an upper limit. Actual Central/Inner Asian admixture might be somewhat lower as some of the related lineages may have come from a common third source. The main haplogroups responsible for the Central/Inner Asian admixture among Hungarians are J2*-M172 (xM47, M67, M12), J2-L24, R1a-Z93; Q-M242 and E-M78. Earlier studies showed very limited Uralic genetic influence among Hungarians, and based on the present study, Altaic/Turkic genetic contribution is also not significant, although significantly higher than the Uralic one. The conclusion of this study is that present-day Hungarian speakers are genetically very similar to neighbouring populations, isolated Hungarian speaking groups having relatively higher presence of Central and Inner Asian genetic elements. At the same time, the reliable historical and genetic conclusions require an extension of the study to a significantly larger database with deep haplogroup resolution

  4. Central Plateau Cleanup at DOE's Hanford Site - 12504

    SciTech Connect

    Dowell, Jonathan

    2012-07-01

    The discussion of Hanford's Central Plateau includes significant work in and around the center of the Hanford Site - located about 7 miles from the Columbia River. The Central Plateau is the area to which operations will be shrunk in 2015 when River Corridor cleanup is complete. This work includes retrieval and disposal of buried waste from miles of trenches; the cleanup and closure of massive processing canyons; the clean-out and demolition to 'slab on grade' of the high-hazard Plutonium Finishing Plant; installation of key groundwater treatment facilities to contain and shrink plumes of contaminated groundwater; demolition of all other unneeded facilities; and the completion of decisions about remaining Central Plateau waste sites. A stated goal of EM has been to shrink the footprint of active cleanup to less than 10 square miles by 2020. By the end of FY2011, Hanford will have reduced the active footprint of cleanup by 64 percent exceeding the goal of 49 percent. By 2015, Hanford will reduce the active footprint of cleanup by more than 90 percent. The remaining footprint reduction will occur between 2015 and 2020. The Central Plateau is a 75-square-mile region near the center of the Hanford Site including the area designated in the Hanford Comprehensive Land Use Plan Environmental Impact Statement (DOE 1999) and Record of Decision (64 FR 61615) as the Industrial-Exclusive Area, a rectangular area of about 20 square miles in the center of the Central Plateau. The Industrial-Exclusive Area contains the 200 East and 200 West Areas that have been used primarily for Hanford's nuclear fuel processing and waste management and disposal activities. The Central Plateau also encompasses the 200 Area CERCLA National Priorities List site. The Central Plateau has a large physical inventory of chemical processing and support facilities, tank systems, liquid and solid waste disposal and storage facilities, utility systems, administrative facilities, and groundwater monitoring

  5. Central control of body temperature

    PubMed Central

    Morrison, Shaun F.

    2016-01-01

    Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis. PMID:27239289

  6. Controlling centrality in complex networks

    PubMed Central

    Nicosia, V.; Criado, R.; Romance, M.; Russo, G.; Latora, V.

    2012-01-01

    Spectral centrality measures allow to identify influential individuals in social groups, to rank Web pages by popularity, and even to determine the impact of scientific researches. The centrality score of a node within a network crucially depends on the entire pattern of connections, so that the usual approach is to compute node centralities once the network structure is assigned. We face here with the inverse problem, that is, we study how to modify the centrality scores of the nodes by acting on the structure of a given network. We show that there exist particular subsets of nodes, called controlling sets, which can assign any prescribed set of centrality values to all the nodes of a graph, by cooperatively tuning the weights of their out-going links. We found that many large networks from the real world have surprisingly small controlling sets, containing even less than 5 – 10% of the nodes. PMID:22355732

  7. North Central Thailand

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This radar image shows the dramatic landscape in the Phang Hoei Range of north central Thailand, about 40 kilometers (25 miles) northeast of the city of Lom Sak. The plateau, shown in green to the left of center, is the area of Phu Kradung National Park. This plateau is a remnant of a once larger plateau, another portion of which is seen along the right side of the image. The plateaus have been dissected by water erosion over thousands of years. Forest areas appear green on the image; agricultural areas and settlements appear as red and blue. North is toward the lower right. The area shown is 38 by 50 kilometers (24 by 31 miles) and is centered at 16.96 degrees north latitude, 101.67 degrees east longitude. Colors are assigned to different radar frequencies and polarizations as follows: red is L-band horizontally transmitted and horizontally received; green is L-band horizontally transmitted and vertically received; blue is C-band horizontally transmitted and vertically received. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) imaging radar on October 3, 1994, when it flew aboard the space shuttle Endeavour. SIR-C/X-SAR is a joint mission of the U.S./German and Italian space agencies.

    Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those changes which are induced by human activity. SIR-C was developed by

  8. North Central Thailand

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This radar image shows the dramatic landscape in the Phang Hoei Range of north central Thailand, about 40 kilometers (25 miles) northeast of the city of Lom Sak. The plateau, shown in green to the left of center, is the area of Phu Kradung National Park. This plateau is a remnant of a once larger plateau, another portion of which is seen along the right side of the image. The plateaus have been dissected by water erosion over thousands of years. Forest areas appear green on the image; agricultural areas and settlements appear as red and blue. North is toward the lower right. The area shown is 38 by 50 kilometers (24 by 31 miles) and is centered at 16.96 degrees north latitude, 101.67 degrees east longitude. Colors are assigned to different radar frequencies and polarizations as follows: red is L-band horizontally transmitted and horizontally received; green is L-band horizontally transmitted and vertically received; blue is C-band horizontally transmitted and vertically received. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) imaging radar on October 3, 1994, when it flew aboard the space shuttle Endeavour. SIR-C/X-SAR is a joint mission of the U.S./German and Italian space agencies.

    Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those changes which are induced by human activity. SIR-C was developed by

  9. DOE/EM Criticality Safety Needs Assessment

    SciTech Connect

    Westfall, Robert Michael; Hopper, Calvin Mitchell

    2011-02-01

    The issue of nuclear criticality safety (NCS) in Department of Energy Environmental Management (DOE/EM) fissionable material operations presents challenges because of the large quantities of material present in the facilities and equipment that are committed to storage and/or material conditioning and dispositioning processes. Given the uncertainty associated with the material and conditions for many DOE/EM fissionable material operations, ensuring safety while maintaining operational efficiency requires the application of the most-effective criticality safety practices. In turn, more-efficient implementation of these practices can be achieved if the best NCS technologies are utilized. In 2002, DOE/EM-1 commissioned a survey of criticality safety technical needs at the major EM sites. These needs were documented in the report Analysis of Nuclear Criticality Safety Technology Supporting the Environmental Management Program, issued May 2002. Subsequent to this study, EM safety management personnel made a commitment to applying the best and latest criticality safety technology, as described by the DOE Nuclear Criticality Safety Program (NCSP). Over the past 7 years, this commitment has enabled the transfer of several new technologies to EM operations. In 2008, it was decided to broaden the basis of the EM NCS needs assessment to include not only current needs for technologies but also NCS operational areas with potential for improvements in controls, analysis, and regulations. A series of NCS workshops has been conducted over the past years, and needs have been identified and addressed by EM staff and contractor personnel. These workshops were organized and conducted by the EM Criticality Safety Program Manager with administrative and technical support by staff at Oak Ridge National Laboratory (ORNL). This report records the progress made in identifying the needs, determining the approaches for addressing these needs, and assimilating new NCS technologies into EM

  10. Centralized versus Decentralized Information Systems

    NASA Astrophysics Data System (ADS)

    Hugoson, Mats-Åke

    This paper brings into question whether information systems should be centralized or decentralized in order to provide greater support for different business processes. During the last century companies and organizations have used different approaches for centralization and decentralization; a simple answer to the question does not exist. This paper provides a survey of the evolution of centralized and decentralized approaches, mainly in a Nordic perspective. Based on critical reflections on the situation in the end of the century we can discuss what we can learn from history to achieve alignment between centralized and decentralized systems and the business structure. The conclusion is that theories, management and practice for decisions on centralization or decentralization of information systems must be improved. A conscious management and control of centralization /decentralization of IT support is a vital question in the company or the organization, and this is not a task that can be handled only by IT-specialists. There is a need for business oriented IT management of centralization/decentralization.

  11. Central Chemoreceptors: Locations and Functions

    PubMed Central

    Nattie, Eugene; Li, Aihua

    2016-01-01

    Central chemoreception traditionally refers to a change in ventilation attributable to changes in CO2/H+ detected within the brain. Interest in central chemoreception has grown substantially since the previous Handbook of Physiology published in 1986. Initially, central chemoreception was localized to areas on the ventral medullary surface, a hypothesis complemented by the recent identification of neurons with specific phenotypes near one of these areas as putative chemoreceptor cells. However, there is substantial evidence that many sites participate in central chemoreception some located at a distance from the ventral medulla. Functionally, central chemoreception, via the sensing of brain interstitial fluid H+, serves to detect and integrate information on 1) alveolar ventilation (arterial PCO2), 2) brain blood flow and metabolism and 3) acid-base balance, and, in response, can affect breathing, airway resistance, blood pressure (sympathetic tone) and arousal. In addition, central chemoreception provides a tonic ‘drive’ (source of excitation) at the normal, baseline PCO2 level that maintains a degree of functional connectivity among brainstem respiratory neurons necessary to produce eupneic breathing. Central chemoreception responds to small variations in PCO2 to regulate normal gas exchange and to large changes in PCO2 to minimize acid-base changes. Central chemoreceptor sites vary in function with sex and with development. From an evolutionary perspective, central chemoreception grew out of the demands posed by air vs. water breathing, homeothermy, sleep, optimization of the work of breathing with the ‘ideal’ arterial PCO2, and the maintenance of the appropriate pH at 37°C for optimal protein structure and function. PMID:23728974

  12. Centralized digital control of accelerators

    SciTech Connect

    Melen, R.E.

    1983-09-01

    In contrasting the title of this paper with a second paper to be presented at this conference entitled Distributed Digital Control of Accelerators, a potential reader might be led to believe that this paper will focus on systems whose computing intelligence is centered in one or more computers in a centralized location. Instead, this paper will describe the architectural evolution of SLAC's computer based accelerator control systems with respect to the distribution of their intelligence. However, the use of the word centralized in the title is appropriate because these systems are based on the use of centralized large and computationally powerful processors that are typically supported by networks of smaller distributed processors.

  13. The CDF Central Outer Tracker

    SciTech Connect

    Pitts, K.T.; CDF Collaboration

    1997-01-01

    We describe the CDF Central Outer Tracker (COT), an open-cell drift chamber currently being constructed for the CDF detector to run at the upgraded Fermilab Tevatron collider. This detector will provide central tracking with excellent momentum resolution in the high- density environment of a hadron collider. It will be able to resolve 132 ns beam crossings and provide tracking trigger information to the Level 1 trigger. The design is based upon the existing and successful CDF Central Tracking Chamber. The preliminary mechanical and electrical designs are presented. 5 refs., 5 figs., 1 tab.

  14. Demographic tensions in Central America.

    PubMed

    1986-08-01

    This discussion of Central America focuses on the rapid growth of its population, its stagnating economy, and those countries that are socioeconomically advanced. Between 1950-85 the population of Central America tripled, from 9.1 million to 26. 4 million, due to marked mortality declines and the absence of off-setting fertility declines. The distribution of Central Americas's growing populations sets its population growth apart from that of other developing regions. Currently, almost half of all Central Americans live in cities. Although the average growth rate for Central American countries has fallen and is expected to drop further, the decline does not counterbalance the effect of the absolute rise in population numbers. The average annual growth rate of more than 3% annually in the 1960s fell to about 2.6% in recent years, but this decline is due primarily to socioeconomically advanced Costa Rica and Panama. Central America's age structure further complicates the population crisis. About 43% of Central Americans are under the age of 15. When the increasingly larger young population group enters it reproductive years, the potential for future growth (albeit the falling rate of population increase) is unparalleled. UN population projections show the region's population at 40 million by the year 2000. The 1973 oil crisis began a downward spiral for the buoyant post World War II Central American economy. Between 1950-79, real per capita income growth in Central America doubled, with Central American economies growing an average of 5.3% annually. By the early 1980s, overseas markets of the trade-dependent countries of Central America had dried up due to protectionism abroad and slumping basic commodity prices. These and other factors plunged Central America into its current economic malaise of falling real per capita income, rising unemployment, curtailed export led economic growth, and a rising cost of living. In general, economic growth in Central America

  15. Rainfall Induced Natural Disaster in Central America, a challenge for Regional Risk Management

    NASA Astrophysics Data System (ADS)

    Estuardo Guinea Barrientos, Héctor; Swain, Ashok

    2013-04-01

    Rainfall induced natural disasters rank first among all natural disasters in Central America. According to the records of the EM-DAT international database, 248 out of 486 disasters registered in Central America were disasters triggered by rainfall invents, in countries like Belize and Honduras, rainfall-induced natural disasters, mainly floods and landslides, account for more than 90% of the total number of casualties as well as the economic damage of all the disasters. Due to the natural conditions of the Central American Isthmus, precipitation events often struck more than one country at the time, for example Hurricane Mitch in 1998 affected the entire Central American region causing more than 18,000 casualties. In this context, the Central America countries have been working on joint programs and policies aiming transboundary cooperation and management of natural disasters, a clear example of this effort is CEPREDENAC which is the intergovernmental body with the mandate of promoting activities, projects and programs towards reduction of the risks to disasters in order to avoid loss of life and economic assets in the Central America, however, transnational management face several challenges that fall mostly in the political, economical and technical areas. In this paper we described and analyzed the rainfall induced natural disasters, their impacts and the inherent management challenges in the Central American context. Key words: Central America, Natural Disasters, Risk Management, International Cooperation

  16. EMS provider determinations of necessity for transport and reimbursement for EMS response, medical care, and transport: combined resource document for the National Association of EMS Physicians position statements.

    PubMed

    Millin, Michael G; Brown, Lawrence H; Schwartz, Brian

    2011-01-01

    With increasing demands for emergency medical services (EMS), many EMS jurisdictions are utilizing EMS provider-initiated nontransport policies as a method to offload potentially nonemergent patients from the EMS system. EMS provider determination of medical necessity, resulting in nontransport of patients, has the potential to avert unnecessary emergency department visits. However, EMS systems that utilize these policies must have additional education for the providers, a quality improvement process, and active physician oversight. In addition, EMS provider determination of nontransport for a specific situation should be supported by evidence in the peer-reviewed literature that the practice is safe. Further, EMS systems that do not utilize these programs should not be financially penalized. Payment for EMS services should be based on the prudent layperson standard. EMS systems that do utilize nontransport policies should be appropriately reimbursed, as this represents potential cost savings to the health care system.

  17. School Budget Hold'em Facilitator's Guide

    ERIC Educational Resources Information Center

    Education Resource Strategies, 2012

    2012-01-01

    "School Budget Hold'em" is a game designed to help school districts rethink their budgeting process. It evolved out of Education Resource Strategies' (ERS) experience working with large urban districts around the country. "School Budget Hold'em" offers a completely new approach--one that can turn the budgeting process into a long-term visioning…

  18. EM-21 Retrieval Knowledge Center: Waste Retrieval Challenges

    SciTech Connect

    Fellinger, Andrew P.; Rinker, Michael W.; Berglin, Eric J.; Minichan, Richard L.; Poirier, Micheal R.; Gauglitz, Phillip A.; Martin, Bruce A.; Hatchell, Brian K.; Saldivar, Eloy; Mullen, O Dennis; Chapman, Noel F.; Wells, Beric E.; Gibbons, Peter W.

    2009-04-10

    EM-21 is the Waste Processing Division of the Office of Engineering and Technology, within the U.S. Department of Energy’s (DOE) Office of Environmental Management (EM). In August of 2008, EM-21 began an initiative to develop a Retrieval Knowledge Center (RKC) to provide the DOE, high level waste retrieval operators, and technology developers with centralized and focused location to share knowledge and expertise that will be used to address retrieval challenges across the DOE complex. The RKC is also designed to facilitate information sharing across the DOE Waste Site Complex through workshops, and a searchable database of waste retrieval technology information. The database may be used to research effective technology approaches for specific retrieval tasks and to take advantage of the lessons learned from previous operations. It is also expected to be effective for remaining current with state-of-the-art of retrieval technologies and ongoing development within the DOE Complex. To encourage collaboration of DOE sites with waste retrieval issues, the RKC team is co-led by the Savannah River National Laboratory (SRNL) and the Pacific Northwest National Laboratory (PNNL). Two RKC workshops were held in the Fall of 2008. The purpose of these workshops was to define top level waste retrieval functional areas, exchange lessons learned, and develop a path forward to support a strategic business plan focused on technology needs for retrieval. The primary participants involved in these workshops included retrieval personnel and laboratory staff that are associated with Hanford and Savannah River Sites since the majority of remaining DOE waste tanks are located at these sites. This report summarizes and documents the results of the initial RKC workshops. Technology challenges identified from these workshops and presented here are expected to be a key component to defining future RKC-directed tasks designed to facilitate tank waste retrieval solutions.

  19. EM Cep: The Be Star

    NASA Astrophysics Data System (ADS)

    Kochiashvili, N.; Kochiashvili, I.; Natsvlishvili, R.; Vardosanidze, M.; Beradze, S.

    2017-07-01

    On the basis of UBVR photometric data, obtained in the Abastumani Observatory during 1991-1999, very interesting and unusual flare of EM Cep has been revealed. Duration of the flare was over two hours. We estimated the percentage of brightness increase during the flare and brightness decrease of the corresponding anti- flare and the minimum amount of the lost mass during this event. We have solved the light curves of the star using the Wilson-Devinney code. But the resulting fraction of calculated brightness of the companion star was not in accordance with spectral data. Then we decided to check the idea of a pulsating single star using new spectral data. Together with our Buyrakan colleagues we obtained and analyzed spectra of the star. We could not find spectral lines of a companion star or any traces of the radial velocities using this data. Hence, we concluded that we need the higher resolution spectra for final resolution of the matter. On the basis of the latest spectral data of Bulgarian astronomers they concluded that EM Cep is a single star. This makes it possible to suggest, that the question of stellar pulsation could be solved using additional photometric observations.

  20. The EM algorithm in medical imaging.

    PubMed

    Kay, J

    1997-03-01

    This article outlines the statistical developments that have taken place in the use of the EM algorithm in emission and transmission tomography during the past decade or so. We discuss the statistical aspects of the modelling of the projection data for both the emission and transmission cases and define the relevant probability models. This leads to the use of the method of maximum likelihood as a means of estimating the relevant unknown parameters within a given region of a patient's body and to the use of the EM algorithm to compute the reconstruction. Various different types of EM algorithm are discussed, including the SAGE algorithms of Fessler and Hero. The limitations of the EM algorithm, per se, are covered and the need for regularization is stressed. A number of different methods for penalizing the likelihood are described and a number of algorithms for the computation of the penalized EM reconstruction are discussed.

  1. Side mounted EMS for aluminium scrap melters

    SciTech Connect

    Eidem, M.; Tallbaeck, G.; Hanley, P.J.

    1996-10-01

    Normally the electromagnetic stirrer (EMS) is placed below the furnace. However it has recently been found that the EMS can also be placed at the side of the furnace, still giving good stirring. This makes it possible to install EMS on most existing furnaces. The side-mounted EMS is compared with the standard bottom-mounted stirrer with respect to installation, melting time and flow pattern in the melt. The major conclusion is that a side-mounted EMS is practical and will give about as good a performance as the bottom-mounted. Melting time estimates are based upon 3-D fluid flow and heat transfer predictions in combination with a simplified scrap melting theory. Predicted melting times are in fair agreement with operational data for mechanically stirred and electromagnetically bottom stirred furnaces.

  2. Central-Office Real Estate.

    ERIC Educational Resources Information Center

    Pardini, Priscilla

    2003-01-01

    Describes how to upgrade a school district's central-office facilities without incurring taxpayer enmity. Includes case studies from Harford County, Maryland; Orange and Broward Counties, Florida; South Milwaukee, Wisconsin; Mt. Baker, Washington; Chicago, Illinois; and Rochester, New Hampshire. (PKP)

  3. Super Kitchen Centralizes Food Service

    ERIC Educational Resources Information Center

    Modern Schools, 1975

    1975-01-01

    To centralize food service within the entire Pittsburgh school district, a 90,000-square-foot food service preparation building contains cranes and monorails to move 500-pound capacity vats throughout the kitchen. (Author/MLF)

  4. Central Fan Integrated Ventilation Systems

    SciTech Connect

    2009-05-12

    This information sheet describes one example of a ventilation system design, a central fan integrated supply (CFIS) system, a mechanical ventilation and pollutant source control to ensure that there is reasonable indoor air quality inside the house.

  5. The Centrality of Media Economics.

    ERIC Educational Resources Information Center

    Gomery, Douglas

    1993-01-01

    Argues that the study of media economics should stand at the core of the field of communication. Describes central concerns to be addressed, such as economic influence and effect, economic structure and conduct, and analysis of performance. (SR)

  6. Solitary median maxillary central incisor.

    PubMed

    Bolan, Michele; Derech, Carla D'Agostini; Ribeiro, Gerson Luiz Ulema; Pereira, Eliana Ternes; Almeida, Izabel Cristina Santos

    2009-01-01

    Solitary median maxillary central incisor syndrome (SMMCIS) is a rare abnormality characterized by the presence of a central incisor positioned at the maxillary mid-axis. This morphologic defect also can be associated with other diseases. The purpose of this paper was to present a case report of a 4-year-old twin child with SMMCIS. The patient showed a symmetrical primary maxillary central incisor located at the midline, with an absence of labial frenulum, an indistinct philtrum, and an incisive papilla. Radiographic examination confirmed the presence of only a maxillary central incisor in both dentitions. The patient was referred for a genetic and otolaryngological assessment, however, no other abnormality than the ones reported were detected.

  7. Central-Office Real Estate.

    ERIC Educational Resources Information Center

    Pardini, Priscilla

    2003-01-01

    Describes how to upgrade a school district's central-office facilities without incurring taxpayer enmity. Includes case studies from Harford County, Maryland; Orange and Broward Counties, Florida; South Milwaukee, Wisconsin; Mt. Baker, Washington; Chicago, Illinois; and Rochester, New Hampshire. (PKP)

  8. Peripherally inserted central catheter - insertion

    MedlinePlus

    ... nontunneled central venous catheters. In: Mauro MA, Murphy KPJ, Thomson KR, et al., eds. Image-Guided Interventions . ... by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is ...

  9. CENTRAL PLATEAU REMEDIATION OPTIMIZATION STUDY

    SciTech Connect

    BERGMAN, T. B.; STEFANSKI, L. D.; SEELEY, P. N.; ZINSLI, L. C.; CUSACK, L. J.

    2012-09-19

    THE CENTRAL PLATEAU REMEDIATION OPTIMIZATION STUDY WAS CONDUCTED TO DEVELOP AN OPTIMAL SEQUENCE OF REMEDIATION ACTIVITIES IMPLEMENTING THE CERCLA DECISION ON THE CENTRAL PLATEAU. THE STUDY DEFINES A SEQUENCE OF ACTIVITIES THAT RESULT IN AN EFFECTIVE USE OF RESOURCES FROM A STRATEGIC PERSPECTIVE WHEN CONSIDERING EQUIPMENT PROCUREMENT AND STAGING, WORKFORCE MOBILIZATION/DEMOBILIZATION, WORKFORCE LEVELING, WORKFORCE SKILL-MIX, AND OTHER REMEDIATION/DISPOSITION PROJECT EXECUTION PARAMETERS.

  10. Chapter 19: HVAC Controls (DDC/EMS/BAS) Evaluation Protocol

    SciTech Connect

    Romberger, J.

    2014-11-01

    The HVAC Controls Evaluation Protocol is designed to address evaluation issues for direct digital controls/energy management systems/building automation systems (DDC/EMS/BAS) that are installed to control heating, ventilation, and air-conditioning (HVAC) equipment in commercial and institutional buildings. (This chapter refers to the DDC/EMS/BAS measure as HVAC controls.) This protocol may also be applicable to industrial facilities such as clean rooms and labs, which have either significant HVAC equipment or spaces requiring special environmental conditions. This protocol addresses only HVAC-related equipment and the energy savings estimation methods associated with installing such control systems as an energy efficiency measure. The affected equipment includes: Air-side equipment (air handlers, direct expansion systems, furnaces, other heating- and cooling-related devices, terminal air distribution equipment, and fans); Central plant equipment (chillers, cooling towers, boilers, and pumps). These controls may also operate or affect other end uses, such as lighting, domestic hot water, irrigation systems, and life safety systems such as fire alarms and other security systems. Considerable nonenergy benefits, such as maintenance scheduling, system component troubleshooting, equipment failure alarms, and increased equipment lifetime, may also be associated with these systems. When connected to building utility meters, these systems can also be valuable demand-limiting control tools. However, this protocol does not evaluate any of these additional capabilities and benefits.

  11. Viewing Direction Estimation in Cryo-EM Using Synchronization*

    PubMed Central

    Shkolnisky, Yoel; Singer, Amit

    2013-01-01

    A central task in recovering the structure of a macromolecule from cryo-electron microscopy (cryo-EM) images is to determine a three-dimensional model of the macromolecule given many of its two-dimensional projection images. The direction from each image taken the images which was is unknown, and are small and extremely noisy. The goal is to determine the direction from which each image was taken and then to combine the images into a three-dimensional model of the molecule. We present an algorithm for determining the viewing direction of all cryo-EM images at once, which is robust to high levels of noise. The algorithm is based on formulating the problem as a synchronization problem; that is, we estimate the relative spatial configuration of pairs of images and then estimate a global assignment of orientations that maximizes the number of satisfied pairwise relations. Information about the spatial relation between pairs of images is extracted from common lines between triplets of images. These noisy pairwise relations are combined into a single consistent assignment of orientations by constructing a matrix whose entries encode the pairwise relations. This matrix is shown to have rank 3, and its nontrivial eigenspace is shown to reveal the projection orientation of each image. In particular, we show that the nontrivial eigenvectors encode the rotation matrix that corresponds to each image. PMID:24363820

  12. Microstructural evaluation by confocal and electron microscopy in thrombi developed in central venous catheters.

    PubMed

    Lucas, Thabata Coaglio; Silva, Eliata Ester da; Souza, Danilo Olzon Dionysio; Santos, Amanda Rodrigues Dos; Lara, Maristela Oliveira

    2017-08-28

    Evaluating thrombi microstructure developed in central venous catheters using confocal and electron microscopy. An experimental, descriptive study carrying out a microstructural evaluation of venous thrombi developed in central venous catheters using Scanning Electron Microscopy and Confocal Laser Scanning Microscopy. A total of 78 venous catheters were collected over a period of three months. Different fibrin structures were distinguished: fibrin plates, fibrin network, and fibrin fibers. It was observed that the thrombus had thick fibrin plates adhered to the catheter wall openings in both a catheter with three days of permanence as well as in a catheter with 20 days of insertion in the patient. However, a greater amount of erythrocytes and fibrin fibers were found in the central region of the thrombus. This study contributes to improving health care and can have a positive impact on clinical practice, as easy adherence of platelets and fibrins to the catheter wall demonstrated in this study makes it possible to adopt thrombus prevention strategies such as therapy discontinuation for an extended period, blood reflux by a catheter, slow infusion rate and hypercoagulo pathyclinical conditions. Avaliar a microestrutura por microscopia confocal e eletrônica em trombos desenvolvidos em cateteres venosos centrais. Pesquisa experimental, descritiva, em que foi feita uma avaliação microestrutural de trombos venosos desenvolvidos em cateteres venosos centrais por Microscopia Eletrônica de Varredura e Microscopia Confocal de Varredura a Laser. Foram coletados 78 cateteres venosos centrais num período de três meses. Distinguiram-se diferentes estruturas de fibrina: a placa de fibrina, a rede de fibrina e as fibras de fibrina. Observou-se que tanto em um cateter com três dias de permanência quanto em um cateter com 20 dias inserido no paciente o trombo apresentou placas de fibrina espessas aderidas às paredes dos orifícios dos cateteres. Na região central do

  13. Availability of emergency obstetric care (EmOC) among public and private health facilities in rural northwest Bangladesh.

    PubMed

    Sikder, Shegufta S; Labrique, Alain B; Ali, Hasmot; Hanif, Abu A M; Klemm, Rolf D W; Mehra, Sucheta; West, Keith P; Christian, Parul

    2015-01-31

    public facilities. Although EmOC availability and readiness was higher among the surveyed seven most commonly visited private clinics, public facilities appeared to be more affordable for C-section and more geographically accessible. Strategies to retain anesthesiologists and surgeons, such as non-financial incentives, are needed to improve EmOC provision in the public sector. Centralized blood banks are recommended to streamline safe blood acquisition for obstetric surgeries.

  14. Pre-flight risk assessment in Emergency Medical Service (EMS) helicopters

    NASA Technical Reports Server (NTRS)

    Shively, R. J.

    1992-01-01

    The Emergency Medical Service (EMS) industry has been the subject of several television and newspaper articles (Harvey and Jensen, 1987) which emphasized the negative aspects, (e.g., fatalities and high accident rates), rather than the life saving services performed. Until recently, the accident rate of the EMS industry has been five times as high as that of other civil helicopters. This high accident rate has been coupled with the dramatic rise in the number of programs. The industry has built from a single service at its inception in 1972, to over 180 in 1987 (Spray, 1987), to the point that 93 percent of the contiguous U.S. is now covered by some type of EMS service. These factors prompted the National Transportation Safety Board (NTSB) to study the accidents that occurred between May 11, 1978 and December 3, 1986 (NTSB, 1988). The NTSB report concluded that 'Sound pilot judgment is central to safe flight operations.' They further stated that '... factors unique to EMS helicopter operations--such as the influence of the mission itself, program competition, and EMS program management perspectives--can drastically influence pilot judgment during the EMS mission.' One of the most difficult decisions that a pilot must make is whether to accept or decline a mission. A pre-flight risk assessment system (SAFE) was developed at NASA-Ames Research Center for civil EMS operations to aid pilots in making this decision objectively. The ability of the SAFE system to predict mission risk profiles was tested at an EMS facility. The results of this field study demonstrated that the usefulness of SAFE was highly dependent on the type of mission flown. SAFE is now being modified so that it can 'learn' with each mission flown. For example, after flying a mission to a particular site, an EMS pilot would input information about this mission into the system, such as new buildings, wires, or approach procedures. Then, the next time a pilot flew a similar mission or one to the same

  15. Pre-flight risk assessment in Emergency Medical Service (EMS) helicopters

    NASA Technical Reports Server (NTRS)

    Shively, R. J.

    1992-01-01

    The Emergency Medical Service (EMS) industry has been the subject of several television and newspaper articles (Harvey and Jensen, 1987) which emphasized the negative aspects, (e.g., fatalities and high accident rates), rather than the life saving services performed. Until recently, the accident rate of the EMS industry has been five times as high as that of other civil helicopters. This high accident rate has been coupled with the dramatic rise in the number of programs. The industry has built from a single service at its inception in 1972, to over 180 in 1987 (Spray, 1987), to the point that 93 percent of the contiguous U.S. is now covered by some type of EMS service. These factors prompted the National Transportation Safety Board (NTSB) to study the accidents that occurred between May 11, 1978 and December 3, 1986 (NTSB, 1988). The NTSB report concluded that 'Sound pilot judgment is central to safe flight operations.' They further stated that '... factors unique to EMS helicopter operations--such as the influence of the mission itself, program competition, and EMS program management perspectives--can drastically influence pilot judgment during the EMS mission.' One of the most difficult decisions that a pilot must make is whether to accept or decline a mission. A pre-flight risk assessment system (SAFE) was developed at NASA-Ames Research Center for civil EMS operations to aid pilots in making this decision objectively. The ability of the SAFE system to predict mission risk profiles was tested at an EMS facility. The results of this field study demonstrated that the usefulness of SAFE was highly dependent on the type of mission flown. SAFE is now being modified so that it can 'learn' with each mission flown. For example, after flying a mission to a particular site, an EMS pilot would input information about this mission into the system, such as new buildings, wires, or approach procedures. Then, the next time a pilot flew a similar mission or one to the same

  16. Gave 'Em What They Wanted.

    ERIC Educational Resources Information Center

    Pearl, Nancy

    1996-01-01

    From 1963 to 1996, Director Charlie Robinson and Deputy Director Jean-Barry Molz led the Baltimore County Public Library, a system known for customer orientation, a philosophy of collection development heavily emphasizing best sellers, centralized materials selection, interchangeable adult and children's staff, and service fees. Upon retirement,…

  17. Gave 'Em What They Wanted.

    ERIC Educational Resources Information Center

    Pearl, Nancy

    1996-01-01

    From 1963 to 1996, Director Charlie Robinson and Deputy Director Jean-Barry Molz led the Baltimore County Public Library, a system known for customer orientation, a philosophy of collection development heavily emphasizing best sellers, centralized materials selection, interchangeable adult and children's staff, and service fees. Upon retirement,…

  18. Rosette Central Configurations, Degenerate Central Configurations and Bifurcations

    NASA Astrophysics Data System (ADS)

    Lei, J.; Santoprete, M.

    2006-03-01

    In this paper we find a class of new degenerate central configurations and bifurcations in the Newtonian n-body problem. In particular we analyze the Rosette central configurations, namely a coplanar configuration where n particles of mass m 1 lie at the vertices of a regular n-gon, n particles of mass m 2 lie at the vertices of another n-gon concentric with the first, but rotated of an angle π / n, and an additional particle of mass m 0 lies at the center of mass of the system. This system admits two mass parameters μ = m 0/ m 1 and ɛ = m 2/ m 1. We show that, as μ varies, if n > 3, there is a degenerate central configuration and a bifurcation for every ɛ > 0, while if n = 3 there is a bifurcation only for some values of ɛ.

  19. Eolian and riverine contributions to central-Mediterranean sediments: a high-resolution Holocene record

    NASA Astrophysics Data System (ADS)

    Wu, Jiawang; Böning, Philipp; Pahnke, Katharina; Tachikawa, Kazuyo; De Lange, Gert

    2017-04-01

    Circum-Mediterranean climate variability is reflected in sediments deposited and preserved at the Mediterranean seafloor. Alternating depositions of organic-lean marls and organic-rich sapropel sediments in the eastern Mediterranean Sea (EMS) are clearly related to precessional hydroclimate variability. The exact origin for freshwater sources and related changes therein during sapropel formation are still debated. Here, Sr and Nd isotopes and high-resolution elemental ratios from core CP10BC are used to unravel and constrain different eolian and riverine supplies from North Africa and from northern borderlands to the central Mediterranean over the past 9.8 ka. Based on Sr and Nd isotopic and elemental compositions, the provenance for detrital sediments in the Levantine basin can be adequately described using 2-end-members. However, in the central Mediterranean, a three-endmember mixing system is required. The three endmember include Saharan Dust, Aegean/Nile, and Libyan Soil, which respectively represents the eolian supply from North Africa, the riverine inputs from the Aegean/Nile areas, and the riverine and shelf-derived fluxes from the Libyan-Tunisian margin. For the first time, robust and consistent evidence is given for important riverine supplies from the Libyan-Tunisian margin into the central Mediterranean during sapropel S1 time in particular. Considerable amounts of detrital materials and freshwater must have been delivered into the EMS through the fossil river/wadi systems, which were activated by intensified African monsoon precipitation. A west-east comparison of Sr-Nd isotope data between core CP10BC and 4 other cores throughout the EMS shows that, such detrital supplies originated mainly from western Libya and Tunisia, and were transported as far eastward as 25°E while being diluted by an increasing Nile contribution. The Nile contribution to the central-Mediterranean detrital sediment fraction appears to have been negligible. Moreover, elemental

  20. EM International, July 1994, Volume 2

    SciTech Connect

    Not Available

    1994-10-01

    The Office of Environmental Management (EM) at the Department of Energy (DOE) is seeking out and leveraging foreign technology, data, and resources in keeping with EM`s mandate to protect public health and the environment through the safe and cost-effective remediation of the Department`s nuclear weapons sites. EM works closely with foreign governments, industry, and universities to obtain innovative environmental technologies, scientific and engineering expertise, and operations experience that will support EM`s objectives. Where appropriate, these international resources are used to manage the more urgent risks at our sites, secure a safe workplace, help build consensus on critical issues, and strengthen our technology development program. Through international agreements EM engages in cooperative exchange of information, technology, and individuals. Currently, we are managing agreements with a dozen countries in Europe, Latin America, and Asia. These agreements focus on environmental restoration, waste management, transportation of radioactive wastes, and decontamination and decommissioning. This publication contains the following articles: in situ remediation integrated program; in-situ characterization and inspection of tanks; multimedia environmental pollutant assessment system (MEPAS); LLNL wet oxidation -- AEA technology. Besides these articles, this publication covers: EU activities with Russia; technology transfer activities; and international organization activities.

  1. <em>An Amphibious Magnetotelluric Investigation of the Cascadian Seismogenic and ETS zones.em>

    NASA Astrophysics Data System (ADS)

    Parris, B. A.; Livelybrooks, D.; Bedrosian, P.; Egbert, G. D.; Key, K.; Schultz, A.; Cook, A.; Kant, M.; Wogan, N.; Zeryck, A.

    2015-12-01

    The amphibious Magnetotelluric Observations of Cascadia using a Huge Array (MOCHA) experiment seeks to address unresolved questions about the seismogenic locked zone and down-dip transition zone where episodic tremor and slip (ETS) originates. The presence of free fluids is thought to be one of the primary controls on ETS behavior within the Cascadia margin. Since the bulk electrical conductivity in the crust and mantle can be greatly increased by fluids, magnetotelluric(MT) observations can offer unique insights on the fluid distribution and its relation to observed ETS behavior. Here we present preliminary results from the 146 MT stations collected for the MOCHA project. MOCHA is unique in that it is the first amphibious array of MT stations occupied to provide for 3-D interpretation of conductivity structure of a subduction zone. The MOCHA data set comprises 75 onshore stations and 71 offshore stations, accumulated over a two-year period, and located on an approximate 25km grid, spanning from the trench to the Eastern Willamette Valley, and from central Oregon into middle Washington. We present the results of a series of east-west (cross-strike) oriented, two-dimensional inversions created using the MARE2DEM software that provide an initial picture of the conductivity structure of the locked and ETS zones and its along strike variations. Our models can be used to identify correlations between ETS occurrence rates and inferred fluid concentrations. Our modeling explores the impact of various parameterizations on 2-D inversion results, including inclusion of a smoothness penalty reduction along the inferred slab interface. This series of 2-D inversions can then be used collectively to help make and guide an a priori 3-D inversion. In addition we will present a preliminary 3-D inversion of the onshore stations created using the ModEM software. We are currently working on modifying ModEM to support inversion of offshore data. The more computationally intensive 3-D

  2. Project X RFQ EM Design

    SciTech Connect

    Romanov, Gennady; Hoff, Matthew; Li, Derun; Staples, John; Virostek, Steve; /LBNL

    2012-05-09

    Project X is a proposed multi-MW proton facility at Fermi National Accelerator Laboratory (FNAL). The Project X front-end would consist of an H- ion source, a low-energy beam transport (LEBT), a CW 162.5 MHz radio-frequency quadrupole (RFQ) accelerator, and a medium-energy beam transport (MEBT). Lawrence Berkeley National Laboratory (LBNL) and FNAL collaboration is currently developing the designs for various components in the Project X front end. This paper reports the detailed EM design of the CW 162.5 MHz RFQ that provides bunching of the 1-10 mA H- beam with acceleration from 30 keV to 2.1 MeV.

  3. EM modeling of the central northern portion of Ponta Grossa Arch, Paraná Basin, Brazil

    NASA Astrophysics Data System (ADS)

    Menezes, Paulo de Tarso L.; Travassos, Jandyr Menezes

    2005-05-01

    Broadband remote-referenced magnetotelluric data were collected at 16 sites along a SW-NE profile across one of the main tectonic features of Paraná Basin, the Ponta Grossa Arch. This major structure was uplifted before the voluminous flood basalt event occurred during the Early Cretaceous. Here we present a 2D model for the crustal structure of Paraná Basin traversing the Ponta Grossa Arch. The geoelectrical strike is controlled by NW structures that cut through the crust as indicated by Groom-Bailey decomposition. Several smooth 2D inversions were used as a starting point to a 2D forward modeling exercise where a priori shallow information was used as constraints. That modeling strategy allowed the interpretation of two important regional features, a crustal-scale sub-vertical shear zone (200 Ω m) in a resistive (1000 Ω m) crust and a 30 Ω m lower crustal conductor confined within 25-40 km. We have interpreted the enhanced conductivity in these two features as caused by fluids originated in mantle-derived material. Crustal-scale shear zones are considered elsewhere to be important conduits for the connection of upper and lower crustal fluids. In the studied area the interpreted shear zone can be associated to main lava conduits at the time of the basalt flows. The lower crustal conductor is associated to the hydrated material that intruded, in the base of the crust, during the Mesozoic (crustal underplating).

  4. Coverage centralities for temporal networks*

    NASA Astrophysics Data System (ADS)

    Takaguchi, Taro; Yano, Yosuke; Yoshida, Yuichi

    2016-02-01

    Structure of real networked systems, such as social relationship, can be modeled as temporal networks in which each edge appears only at the prescribed time. Understanding the structure of temporal networks requires quantifying the importance of a temporal vertex, which is a pair of vertex index and time. In this paper, we define two centrality measures of a temporal vertex based on the fastest temporal paths which use the temporal vertex. The definition is free from parameters and robust against the change in time scale on which we focus. In addition, we can efficiently compute these centrality values for all temporal vertices. Using the two centrality measures, we reveal that distributions of these centrality values of real-world temporal networks are heterogeneous. For various datasets, we also demonstrate that a majority of the highly central temporal vertices are located within a narrow time window around a particular time. In other words, there is a bottleneck time at which most information sent in the temporal network passes through a small number of temporal vertices, which suggests an important role of these temporal vertices in spreading phenomena. Contribution to the Topical Issue "Temporal Network Theory and Applications", edited by Petter Holme.Supplementary material in the form of one pdf file available from the Journal web page at http://dx.doi.org/10.1140/epjb/e2016-60498-7

  5. Inferring Centrality from Network Snapshots

    NASA Astrophysics Data System (ADS)

    Shao, Haibin; Mesbahi, Mehran; Li, Dewei; Xi, Yugeng

    2017-01-01

    The topology and dynamics of a complex network shape its functionality. However, the topologies of many large-scale networks are either unavailable or incomplete. Without the explicit knowledge of network topology, we show how the data generated from the network dynamics can be utilised to infer the tempo centrality, which is proposed to quantify the influence of nodes in a consensus network. We show that the tempo centrality can be used to construct an accurate estimate of both the propagation rate of influence exerted on consensus networks and the Kirchhoff index of the underlying graph. Moreover, the tempo centrality also encodes the disturbance rejection of nodes in a consensus network. Our findings provide an approach to infer the performance of a consensus network from its temporal data.

  6. Central Hyperthermia Treated with Bromocriptine

    PubMed Central

    Natteru, P.; George, P.; Bell, R.; Nattanmai, P.

    2017-01-01

    Introduction. Central hyperthermia is common in patients with brain injury. It typically has a rapid onset with high temperatures and marked fluctuations and responds poorly to antibiotics and antipyretics. It is also associated with worse outcomes in the brain injured patient. Recognizing this, it is important to aggressively manage it. Case Report. We report a 34-year-old male with a right thalamic hemorrhage extending to the midbrain and into the ventricles. During his admission, he developed intractable fevers with core temperatures as high as 39.3°C. Infectious workup was unremarkable. The fever persisted despite empiric antibiotics, antipyretics, and cooling wraps. Bromocriptine was started resulting in control of the central hyperthermia. The fever spikes were reduced to minor fluctuations that significantly worsened with any attempt to wean off the bromocriptine. Conclusion. Diagnosing and managing central hyperthermia can be challenging. The use of bromocriptine can be beneficial as we have reported. PMID:28348904

  7. Inferring Centrality from Network Snapshots

    PubMed Central

    Shao, Haibin; Mesbahi, Mehran; Li, Dewei; Xi, Yugeng

    2017-01-01

    The topology and dynamics of a complex network shape its functionality. However, the topologies of many large-scale networks are either unavailable or incomplete. Without the explicit knowledge of network topology, we show how the data generated from the network dynamics can be utilised to infer the tempo centrality, which is proposed to quantify the influence of nodes in a consensus network. We show that the tempo centrality can be used to construct an accurate estimate of both the propagation rate of influence exerted on consensus networks and the Kirchhoff index of the underlying graph. Moreover, the tempo centrality also encodes the disturbance rejection of nodes in a consensus network. Our findings provide an approach to infer the performance of a consensus network from its temporal data. PMID:28098166

  8. Stability analysis, modeling, simulation and experimental testing of an EMS Maglev system with structural flexibility

    NASA Astrophysics Data System (ADS)

    Hanasoge, Aravind M.

    Vehicle-guideway interaction studies of Magnetically Levitated (Maglev) vehicles indicate that structural flexibility can adversely affect the overall stability and performance of such systems. This is one of the reasons why guideways are generally made very rigid. This in turn leads to increased cost of the overall system since guideway construction forms a significant portion of the overall cost. In this dissertation, the influence of structural flexibility on the stability of Electromagnetic Suspension (EMS) Maglev systems is studied. It is shown how inherently unstable and flexible structure EMS Maglev systems can achieve guaranteed stability by using collocated actuators and sensors, along with de-centralized Proportional plus Derivative (PD) controllers. These results are valid even in the presence of Track/Guideway flexibility. A detailed dynamic model is developed for the EMS Maglev demonstration system (Test Bogie) currently under research and development at Old Dominion University (ODU). This model incorporates structural dynamics with flexible modes of vibration, non-linear electrodynamics, feedback controllers, discrete time implementation, noise filters and disturbance inputs. This model is validated via real time experimental testing. The model thus validated is used for simulation case studies involving levitation and lateral disturbance, lateral control, and centralized control.

  9. MRDIS Standalone Central Alarm Station

    SciTech Connect

    2012-09-12

    The MRDIS Standalone Central Alarm Station(MRDIS-CAS} is a software system for receiving, storing, and reviewing radiation data collected by the Mobile Radiation Detection and Identification System (MRDIS}, a mobile radiation scanning system developed for use in foreign ports for the DOE Megaports Initiative. It is designed to run on one of the on board computers in the MRDIS cab. It will collect, store, and display data from the MRDIS without the need for wireless communications or centralized server technology. It is intended to be a lightweight replacement for a distributed Megaports communication system in ports where the necessary communications infrastructure does not exist for a full Megaports communications system.

  10. Geothermal activities in Central America

    SciTech Connect

    Whetten, J.T.; Hanold, R.J.

    1985-09-11

    The Agency for International Development is funding a new program in energy and minerals for Central America. Geothermal energy is an important component. A country-wide geothermal assessment has started in Honduras, and other assessment activities are in progress or planned for Costa Rica, El Salvador, Guatemala, and Panama. Instrumentation for well logging has been provided to Costa Rica, and a self-contained logging truck will be made available for use throughout Central America. An important objective of this program is to involve the private sector in resource development. 4 refs., 3 figs.

  11. National Energy Efficiency Evaluation, Measurement and Verification (EM&V) Standard: Scoping Study of Issues and Implementation Requirements

    SciTech Connect

    Schiller Consulting, Inc.; Schiller, Steven R.; Goldman, Charles A.; Galawish, Elsia

    2011-02-04

    This report is a scoping study that identifies issues associated with developing a national evaluation, measurement and verification (EM&V) standard for end-use, non-transportation, energy efficiency activities. The objectives of this study are to identify the scope of such a standard and define EM&V requirements and issues that will need to be addressed in a standard. To explore these issues, we provide and discuss: (1) a set of definitions applicable to an EM&V standard; (2) a literature review of existing guidelines, standards, and 'initiatives' relating to EM&V standards as well as a review of 'bottom-up' versus 'top-down' evaluation approaches; (3) a summary of EM&V related provisions of two recent federal legislative proposals (Congressman Waxman's and Markey's American Clean Energy and Security Act of 2009 and Senator Bingaman's American Clean Energy Leadership Act of 2009) that include national efficiency resource requirements; (4) an annotated list of issues that that are likely to be central to, and need to be considered when, developing a national EM&V standard; and (5) a discussion of the implications of such issues. There are three primary reasons for developing a national efficiency EM&V standard. First, some policy makers, regulators and practitioners believe that a national standard would streamline EM&V implementation, reduce costs and complexity, and improve comparability of results across jurisdictions; although there are benefits associated with each jurisdiction setting its own EM&V requirements based on their specific portfolio and evaluation budgets and objectives. Secondly, if energy efficiency is determined by the US Environmental Protection Agency to be a Best Available Control Technology (BACT) for avoiding criteria pollutant and/or greenhouse gas emissions, then a standard can be required for documenting the emission reductions resulting from efficiency actions. The third reason for a national EM&V standard is that such a standard is

  12. NEIC Environmental Management System (EMS) Policy

    EPA Pesticide Factsheets

    National Enforcement Investigations Center (NEIC) Environmental Management System (EMS) Policy. Identification and management of actual and potential environmental impacts of operations and decisions for the purpose of continual improvement of performance

  13. EMS offshore. A new horizon for paramedics.

    PubMed

    Mallard, A S

    1991-10-01

    The difficulty in getting medical aid to offshore drilling platforms can be a source of life-threatening delays. Recently, some companies have charted new waters by actually stationing EMS crews on their rigs.

  14. How good can cryo-EM become?

    SciTech Connect

    Glaeser, Robert M.

    2015-12-30

    The suddenness with which single-particle cryo-electron microscopy (cryo-EM) has emerged as a method for determining high-resolution structures of biological macromolecules invites the questions, how much better can this technology get, and how fast is that likely to happen? While we can rightly celebrate the maturation of cryo-EM as a high-resolution structure-determination tool, I believe there still are many developments to look forward to.

  15. Reassessing training levels for prehospital EMS personnel.

    PubMed

    Briese, G L

    1983-01-01

    One of the major questions confronting prehospital care services today concerns determining the appropriate level of training for EMS personnel that will provide the most cost effective systems. Unfortunately there are no studies which assess this problem. Various communities have modified or expanded the roles of prehospital personnel beyond the traditional training of EMTs and paramedics. Continuing education and skills maintenance are ongoing problems faced by all EMS systems, which have been addressed in various ways by individual locales.

  16. Fire management in central America

    Treesearch

    Andrea L. Koonce; Armando González-Cabán

    1992-01-01

    Information on fire management operations in Central America is scant. To evaluate the known level of fire occurrence in seven countries in that area, fire management officers were asked to provide information on their fire control organizations and on any available fire statistics. The seven countries surveyed were Guatemala, Belize, Honduras, El Salvador, Nicaragua,...

  17. The Centrality of Ethical Leadership

    ERIC Educational Resources Information Center

    Ehrich, Lisa C.; Harris, Jessica; Klenowski, Val; Smeed, Judy; Spina, Nerida

    2015-01-01

    Purpose: The central argument in this paper is that ethical school leadership is imperative in a context of increasing performance-driven accountability. The purpose of this paper is to focus on school principals' perceptions of how they understand ethical leadership and how they lead the ethical use of data. Design/Methodology/Approach: This…

  18. Putting Central Registers to Work

    ERIC Educational Resources Information Center

    Besharov, Douglas J.

    1977-01-01

    Cites shortcomings of existing centralized state systems for processing child protection case records. Diagnostic, monitoring and statistical functions of these registers are described as severely limited by inaccurate and incomplete reporting. Confidentiality of records, subjects' access to records and problems of verification are discussed. (BF)

  19. Central Statistical Libraries in Europe.

    ERIC Educational Resources Information Center

    Kaiser, Lisa

    The paper tries to clarify the position special governmental libraries hold in the system of libraries of today by investigating only one specific type of library mainly from a formal and historical point of view. Central statistical libraries in Europe were first regarded as administrative and archival libraries. Their early holdings of foreign…

  20. Earth Works Central. [Educational Packet].

    ERIC Educational Resources Information Center

    Kids for Saving Earth Worldwide, Minneapolis, MN.

    Earth Works Central is an educational curriculum tool designed to provide environmental education support for the classroom. It features environmental materials for science, geography, history, art, music, dramatics, and physical education. It includes information on creating an environmental center where kids can learn and become empowered to…

  1. Readability of Central Florida Newspapers.

    ERIC Educational Resources Information Center

    Olmstead, Phyllis M.

    A study analyzed the readability of seven central Florida newspapers (one of which is a college newspaper) and "USA Today.""Rightwriter," a grammar checker and readability computer program, was used to evaluate front page articles for each of the eight newspapers. The readability formulas invoked in the readability program…

  2. Central Asian Drug Trafficking Dilemma

    DTIC Science & Technology

    2003-12-01

    DRUG ADDICTION AND HIV/AIDS ........................................................18 G. UNITED STATES AND RUSSIA...throughout the area since the breakup. Heroin , opium, hashish, cocaine, and many other large-scale drugs have spread throughout the region in epidemic...The wider Central Asia region was experiencing a sharp rise in drug addiction . Tajikistan is not a major producer of narcotics, but is a major

  3. Despair at the Central Office.

    ERIC Educational Resources Information Center

    Tewel, Kenneth J.

    1995-01-01

    The psychological fallout of school restructuring can paralyze central office staff. Superintendents need effective incentives to keep people engaged in organization-building. They must create a trusting, risk-taking environment, develop a shared mission, empower staff to make decisions, provide learning opportunities, afford professional…

  4. Investing in the Central Office

    ERIC Educational Resources Information Center

    Shields, Regis Anne

    2010-01-01

    Benchmarking against similar districts, ideally higher-performing ones, can be a valuable tool for determining the appropriate level of central-office investment. Unfortunately, reliable benchmarks on district spending in teaching and learning support are not readily available. This should not preclude districts from using this valuable method to…

  5. Music Libraries: Centralization versus Decentralization.

    ERIC Educational Resources Information Center

    Kuyper-Rushing, Lois

    2002-01-01

    Considers the decision that branch libraries, music libraries in particular, have struggled with concerning a centralized location in the main library versus a decentralized collection. Reports on a study of the Association of Research Libraries that investigated the location of music libraries, motivation for the location, degrees offered,…

  6. The Centrality of Ethical Leadership

    ERIC Educational Resources Information Center

    Ehrich, Lisa C.; Harris, Jessica; Klenowski, Val; Smeed, Judy; Spina, Nerida

    2015-01-01

    Purpose: The central argument in this paper is that ethical school leadership is imperative in a context of increasing performance-driven accountability. The purpose of this paper is to focus on school principals' perceptions of how they understand ethical leadership and how they lead the ethical use of data. Design/Methodology/Approach: This…

  7. Grazing in central hardwood forests

    Treesearch

    Robert A. McQuilkin; Harold Scholten

    1989-01-01

    Woodland grazing is a major forestry and land management problem in parts of the central hardwood region. Most forest grazing is by cattle and, to a lesser extent, hogs in woodlands adjacent to pastures or feedlots. The practice is particularly common in the cattle producing areas of the Corn Belt where often 50 percent or more of the upland forest is grazed. Woodland...

  8. Illustrating the Central Limit Theorem

    ERIC Educational Resources Information Center

    Corcoran, Mimi

    2016-01-01

    Statistics is enjoying some well-deserved limelight across mathematics curricula of late. Some statistical concepts, however, are not especially intuitive, and students struggle to comprehend and apply them. As an AP Statistics teacher, the author appreciates the central limit theorem as a foundational concept that plays a crucial role in…

  9. Central Bureau Status and Perspective

    NASA Technical Reports Server (NTRS)

    Neilan, Ruth

    2004-01-01

    The Central Bureau continues to promote the IGS organization, data and data products as setting the world standard for GPS/GNSS geodetic applications as outlined in the IGS Strategic Plan. The Central Bureau was responsible for the organization of the strategic planning process, preparation of all documents, and the editing and publication of the plan. This was a major activity and the Board s consensus on the plan is a significant milestone in the evolution of the IGS. The Central Bureau is responsible for the day-to-day management of the Service. With 200 organizations in over 80 countries and a ground network of approx. 350 stations, this requires daily interfaces on many different levels globally. The separate summary of the IGS Network Coordinator is included in this annual report and demonstrates the vital technical tasks of the Central Bureau. The CB is also responsible to arrange and organize all Board activities and is involved in the supporting the planning and logistics of all IGS workshops and meetings.

  10. Chapter 1: Central Arizona Highlands

    Treesearch

    Peter F. Ffolliott

    1999-01-01

    The Central Arizona Highlands are a distinct biogeographic, climatic, and physiographic province that forms a diverse ecotone between the larger Colorado Plateau to the north and the Sonoran Desert ecoregions to the south (figure 1). The Highlands coincide approximately with the Arizona Transition Zone identified by ecologists, geologists and others. This region is one...

  11. Central configurations for -body problems

    NASA Astrophysics Data System (ADS)

    Zhao, Furong; Chen, Jian

    2015-01-01

    We show the existence of planar central configurations for -body problems with Newtonian potentials; in such configurations, -bodies are located at the vertices of regular -gons with a common center, where regular -gons are homothetic, and regular -gons are homothetic rotated by compared to the first set of -gons, and all masses on the same -gon are equal.

  12. The CMS central hadron calorimeter

    SciTech Connect

    Freeman, J.; E892 Collaboration

    1996-12-31

    The CMS central hadron calorimeter is a copper absorber/ scintillator sampling structure. We describe design choices that led us to this concept, details of the mechanical and optical structure, and test beam results. We discuss calibration techniques, and finally the anticipated construction schedule.

  13. Illustrating the Central Limit Theorem

    ERIC Educational Resources Information Center

    Corcoran, Mimi

    2016-01-01

    Statistics is enjoying some well-deserved limelight across mathematics curricula of late. Some statistical concepts, however, are not especially intuitive, and students struggle to comprehend and apply them. As an AP Statistics teacher, the author appreciates the central limit theorem as a foundational concept that plays a crucial role in…

  14. Forest statistics of central Kentucky

    Treesearch

    The Forest Survey Organization. Central States Forest Experiment Station

    1950-01-01

    This Survey Release presents the more significant preliminary statistics on the forest area and timber volume for each of the four regions of Central Kentucky. A similar report has been published for the Western Kentucky region and a release for the eastern region will be issued as soon as field work and tabulations are completed. Later an analytical report for the...

  15. Central America: A Regional Study.

    ERIC Educational Resources Information Center

    Mowry, George; Lacy, Ann

    This lesson is a series of activities and multi-media presentations designed to enable students to understand the historic and geographic roots of some of the problems that Central American nations have faced. Geography, history, writing, and storytelling are used as ways of understanding a multicultural world. Creative thinking and participation…

  16. Today's central receiver power plant

    NASA Astrophysics Data System (ADS)

    Alpert, D. J.; Kolb, G. J.; Chavez, J. M.

    1991-04-01

    For 15 years, the United States Department of Energy has worked with industry, both utilities and manufacturers, to develop the technology of solar central receiver power plants. In this type of plant, sunlight is concentrated by a field of sun-tracking mirrors, called heliostats, onto a centrally located receiver. The solar energy is collected in the form of a heated fluid, which is used to generate steam to power a conventional turbine generator. For a number of reasons, molten nitrate salt is now the preferred heat transfer fluid. Commercial plants will be sized between 100 and 200 MW. The impetus for developing central receivers comes from their unique advantages: (1) they produce clean, reliable, low-cost electricity; (2) they have practical energy storage that provides a high degree of dispatchability (annually up to 60 percent) - without fossil fuels; and (3) they are environmentally benign. Development efforts around the world have brought the technology to the brink of commercialization: The technical feasibility has been proven, and cost, performance, and reliability can be confidently predicted. Plans are currently being developed for the final steps toward commercial central receiver power plants.

  17. Central New York's New Workforce

    ERIC Educational Resources Information Center

    Center for an Urban Future, 2009

    2009-01-01

    Conducted in late 2008 in partnership with the Greater Syracuse Chamber of Commerce and the Mohawk Valley Chamber of Commerce, this is the largest survey ever taken of Central New York businesses regarding the English language skills of the area workforce. The online survey was emailed to several hundred local businesses; 126 responses were…

  18. Central Corneal Thickness in Children

    PubMed Central

    2011-01-01

    Objective To report the central corneal thickness (CCT) in healthy white, African-American, and Hispanic children from birth to 17 years of age. Design Prospective observational multicenter study. Central corneal thickness was measured with a hand-held contact pachymeter. Results Two thousand seventy-nine children were included in the study, with ages ranging from day of birth to 17 years. Included were 807 white, 494 Hispanic, and 474 African-American individuals, in addition to Asian, unknown and mixed race individuals. African-American children had thinner corneas on average than that of both white (p< .001) and Hispanic children (p< .001) by approximately 20 micrometers. Thicker median CCT was observed with each successive year of age from age 1 to 11 years, with year-to-year differences steadily decreasing and reaching a plateau after age 11 at 573 micrometers in white and Hispanic children and 551 micrometers in African-American children. For every 100 micrometers of thicker CCT measured, the intraocular pressure was 1.5 mmHg higher on average (p< 0.001). For every diopter of increased myopic refractive error (p< 0.001) CCT was 1 micrometer thinner on average. Conclusions Median CCT increases with age from 1 to 11 years with the greatest increase present in the youngest age groups. African-American children on average have thinner central corneas than white and Hispanic children, while white and Hispanic children demonstrate similar central corneal thickness. PMID:21911662

  19. Central American geologic map project

    SciTech Connect

    Dengo, G.

    1986-07-01

    During the Northeast Quadrant Panel meeting of the Circum-Pacific Map Project held in Mexico City, February 1985, Central American panel members proposed and adopted plans for compiling a geologic map of Central America, probably at a scale of 1:500,000. A local group with participants from each country was organized and coordinated by Rolando Castillo, director, Central American School of Geology, University of Costa Rica, for the geologic aspects, and Fernando Rudin, director, Geographic Institute of Costa Rica, for the topographic base. In 1956, the US Geological Survey published a geologic map of the region at a scale of 1:1 million. Subsequent topographic and geologic mapping projects have provided a large amount of new data. The entire area is now covered by topographic maps at a scale of 1:50,000, and these maps have been used in several countries as a base for geologic mapping. Another regional map, the Metallogenic Map of Central America (scale = 1:2 million), was published in 1969 by the Central American Research Institute for Industry (ICAITI) with a generalized but updated geologic base map. Between 1969 and 1980, maps for each country were published by local institutions: Guatemala-Belize at 1:500,000, Honduras at 1:500,000, El Salvador at 1:100,000, Nicaragua at 1:1 million, Costa Rica at 1:200,000, and Panama at 1:1 million. This information, in addition to that of newly mapped areas, served as the base for the Central American part of the Geologic-Tectonic Map of the Caribbean Region (scale = 1:2.5 million), published by the US Geological Survey in 1980, and also fro the Northeast Quadrant Maps of the Circum-Pacific Region. The new project also involves bathymetric and geologic mapping of the Pacific and Caribbean margins of the Central American Isthmus. A substantial amount of new information of the Middle America Trench has been acquired through DSDP Legs 67 and 84.

  20. 34 CFR 303.301 - Central directory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Central directory. 303.301 Section 303.301 Education....301 Central directory. (a) Each system must include a central directory of information about— (1... to contact, by telephone or letter, any of the sources listed in the directory. (c) The central...

  1. Network Centrality of Metro Systems

    PubMed Central

    Derrible, Sybil

    2012-01-01

    Whilst being hailed as the remedy to the world’s ills, cities will need to adapt in the 21st century. In particular, the role of public transport is likely to increase significantly, and new methods and technics to better plan transit systems are in dire need. This paper examines one fundamental aspect of transit: network centrality. By applying the notion of betweenness centrality to 28 worldwide metro systems, the main goal of this paper is to study the emergence of global trends in the evolution of centrality with network size and examine several individual systems in more detail. Betweenness was notably found to consistently become more evenly distributed with size (i.e. no “winner takes all”) unlike other complex network properties. Two distinct regimes were also observed that are representative of their structure. Moreover, the share of betweenness was found to decrease in a power law with size (with exponent 1 for the average node), but the share of most central nodes decreases much slower than least central nodes (0.87 vs. 2.48). Finally the betweenness of individual stations in several systems were examined, which can be useful to locate stations where passengers can be redistributed to relieve pressure from overcrowded stations. Overall, this study offers significant insights that can help planners in their task to design the systems of tomorrow, and similar undertakings can easily be imagined to other urban infrastructure systems (e.g., electricity grid, water/wastewater system, etc.) to develop more sustainable cities. PMID:22792373

  2. Public water supplies in central and north-central Texas

    USGS Publications Warehouse

    Sundstrom, Raymond W.; Broadhurst, W.L.; Dwyer, B.C.

    1949-01-01

    This report gives a summarized description of the public water supplies in 35 counties of central and north-central Texas, extending from the southern boundaries of Travis, Blanco, Gillespie, and Kerr Counties northward to the TexasOklahoma State line. It gives the available data as follows for each of the 145 communities: Population of the community; name of the official from whom the information was obtained; ownership of water works, whether private or municipal source of supply, whether ground water or surface water; the amount of water consumed; the facilities for storage; the number of customers served; the character of the chemical and sanitary treatment, if any; and chemical analyses of the water. Where ground water is used, the following is also given: Records of wells, including drillers' logs; character of the pumping equipment; yields of the wells, and records of water levels, if available.

  3. Is Central Asia really exsiccating?

    NASA Astrophysics Data System (ADS)

    Aizen, V. B.; Aizen, E. M.; Surazakov, A. B.

    2008-12-01

    At the end of 20th and the beginning of 21st century central Asia oases suffered from serious drought caused lack of water for agriculture, economy growth and population increase. However, people of this region always experienced lack of water for irrigation and fought a war over the rights to control river streams. The drying up of central Asian rivers is not a new phenomenon according to the ancient manuscripts. Thus, lets see about what has happened with the past century climate and water resources of central Asia using the long-term observational data. We analyzed data from more than 200 meteorological stations and stream gauges over the central Asia in elevation range from 25 m. b.s.l. to 4,000 m. a.s.l. to understand the last 100 years variability in climate and water resources, examining changes in the extreme and mean monthly air temperatures, precipitation and river runoff. The evaluation of seasonal snow and glacier's covered areas between 1970th and 2007th in central Asia derived from AVHRR, MODIS, Hexagon KH-9, Landsat ETM and ASTER data exhibit 15% reduction of the seasonal snow covered area and 10.1% of the glacier area. It has been found that during last twenty years the duration of snowmelt, from the date of maximum snow cover to date of its disappearance, reduced by 30 days and in 2007 was equal to 138 days in the central Asian mountains. The decrease of seasonal snow cover is not a linear process. The further decrease may be accelerated due to increase of rainfall instead of snowfall in early spring months at high elevations, and consequently a lesser heat expenditure for the snowmelt. The growth in summer air temperatures, especially observable since the 1970th, accompanied by increase of evapotranspiration and precipitation, notably in summer and autumn, and at high elevations over 3,000 m, and at the western peripheral mountain ridges. Average difference in the means of annual air temperatures for the two thirty-year periods before and after

  4. The Bivariate Central Normal Distribution

    NASA Astrophysics Data System (ADS)

    Pratikno, B.; Jajang; Putri, A. C. C.; Haryono, Y. W. W.

    2017-04-01

    The research studied Probability Density Function (pdf), Cumulative Distribution Function (CDF) and graphical analysis of the bivariate central normal distribution. The CDF of this distribution is then used to compute power of the test Pre-Test-Test (PTT) in the testing intercept. The tables and graphs of the pdf (and CDF) of the bivariate central normal distribution (BCND) and power of the test in testing intercept are produced using R-code. The results showed that the mean and coefficient correlation have a significant affect on the curve, but the variance is not. The curves tend to be leptokurtic for small coefficient correlation, and they will be mesocurtic for large coefficient correlation. The power of the PTT increases as the CDF of the BCND increases.

  5. The Central Valley Hydrologic Model

    NASA Astrophysics Data System (ADS)

    Faunt, C.; Belitz, K.; Hanson, R. T.

    2009-12-01

    Historically, California’s Central Valley has been one of the most productive agricultural regions in the world. The Central Valley also is rapidly becoming an important area for California’s expanding urban population. In response to this competition for water, a number of water-related issues have gained prominence: conjunctive use, artificial recharge, hydrologic implications of land-use change, subsidence, and effects of climate variability. To provide information to stakeholders addressing these issues, the USGS made a detailed assessment of the Central Valley aquifer system that includes the present status of water resources and how these resources have changed over time. The principal product of this assessment is a tool, referred to as the Central Valley Hydrologic Model (CVHM), that simulates surface-water flows, groundwater flows, and land subsidence in response to stresses from human uses and from climate variability throughout the entire Central Valley. The CVHM utilizes MODFLOW combined with a new tool called “Farm Process” to simulate groundwater and surface-water flow, irrigated agriculture, land subsidence, and other key processes in the Central Valley on a monthly basis. This model was discretized horizontally into 20,000 1-mi2 cells and vertically into 10 layers ranging in thickness from 50 feet at the land surface to 750 feet at depth. A texture model constructed by using data from more than 8,500 drillers’ logs was used to estimate hydraulic properties. Unmetered pumpage and surface-water deliveries for 21 water-balance regions were simulated with the Farm Process. Model results indicate that human activities, predominately surface-water deliveries and groundwater pumping for irrigated agriculture, have dramatically influenced the hydrology of the Central Valley. These human activities have increased flow though the aquifer system by about a factor of six compared to pre-development conditions. The simulated hydrology reflects spatial

  6. A centralized audio presentation manager

    SciTech Connect

    Papp, A.L. III; Blattner, M.M.

    1994-05-16

    The centralized audio presentation manager addresses the problems which occur when multiple programs running simultaneously attempt to use the audio output of a computer system. Time dependence of sound means that certain auditory messages must be scheduled simultaneously, which can lead to perceptual problems due to psychoacoustic phenomena. Furthermore, the combination of speech and nonspeech audio is examined; each presents its own problems of perceptibility in an acoustic environment composed of multiple auditory streams. The centralized audio presentation manager receives abstract parameterized message requests from the currently running programs, and attempts to create and present a sonic representation in the most perceptible manner through the use of a theoretically and empirically designed rule set.

  7. Central exclusive production at RHIC

    SciTech Connect

    Adamczyk, Leszek; Guryn, Włodek; Turnau, Jacek

    2014-11-10

    The present status and future plans of the physics program of Central Exclusive Production (CEP) at RHIC are described. The measurements are based on the detection of the forward protons from the Double Pomeron Exchange (DPE) process in the Roman Pot system and of the recoil system of charged particles from the DPE process measured in the STAR experiment’s Time Projection Chamber (TPC). The data described here were taken using polarized proton-proton collisions at ps = 200 GeV. The preliminary spectra of two pion and four pion invariant mass reconstructed by STAR TPC in central region of pseudo-rapidity | | < 1, are presented. Near future plans to take data with the current system at center-of-mass energy ps = 200 GeV and plans to upgrade the forward proton tagging sys- tem are presented. Also a possible addition of the Roman Pots to the sPHENIX detector is discussed.

  8. [Central agenesis of the hand].

    PubMed

    Turki, Moez; Daghfous, Mehdi; Ennouri, Khalil; Khalfaoui, Faouzi; Baccari, Sayed; Tarhouni, Lamjed; Bahri, Hichem

    2002-06-01

    Central aplasia represent under 10% of congenital malformations of the hand. It is characterised by the partial or complete absence of the median ray. We adopted the classification of Swanson and considered this anomaly a stop of median longitudinal development. We separate 2 groups: Hand in folk: the aplasia interested only the median digits, all metacarpal are present. Hand in lobster's pincer: all median rays are absent including the metacarpal. We report a set of 16 children carriers of 23 central aplasia of the hand, it was about 14 hands in lobster'pincer and 9 hands in folk. In any case, the gene was merely aesthetic, the hand's function was complete. A child has been operated, and benefitted a closing of the median crack defect, he had a free thumb. For the other cases, abstention has been decided, indeed to close this cracks deprive these hands of a first corner the alone present.

  9. Central Nucleon-Nucleon Potential

    NASA Astrophysics Data System (ADS)

    Robilotta, M. R.

    2001-12-01

    The outer region of the NN interactions is dominated by the one pion exchange potential (OPEP), followed by the two-pion exchange potential (TPEP). Chiral calculations of the TPEP have been performed using either heavy baryon1 (HB) or relativistic2 perturbation theories. We compare the predictions from these two approaches for the dominant central interaction and show that they fail to agree by 25% ...

  10. Central collisions of heavy ions

    SciTech Connect

    Fung, Sun-yiu.

    1992-10-01

    This report describes the activities of the Heavy Ion Physics Group at the University of California, Riverside from October 1, 1991 to September 30, 1992. During this period, the program focused on particle production at AGS energies, and correlation studies at the Bevalac in nucleus-nucleus central collisions. As part of the PHENIX collaboration, contributions were made to the Preliminary Conceptual Design Report (pCDR), and work on a RHIC silicon microstrip detector R D project was performed.

  11. Tectonics of the central Andes

    NASA Technical Reports Server (NTRS)

    Bloom, Arthur L.; Isacks, Bryan L.; Fielding, Eric J.; Fox, Andrew N.; Gubbels, Timothy L.

    1989-01-01

    Acquisition of nearly complete coverage of Thematic Mapper data for the central Andes between about 15 to 34 degrees S has stimulated a comprehensive and unprecedented study of the interaction of tectonics and climate in a young and actively developing major continental mountain belt. The current state of the synoptic mapping of key physiographic, tectonic, and climatic indicators of the dynamics of the mountain/climate system are briefly reviewed.

  12. Geochronology Database for Central Colorado

    USGS Publications Warehouse

    Klein, T.L.; Evans, K.V.; deWitt, E.H.

    2010-01-01

    This database is a compilation of published and some unpublished isotopic and fission track age determinations in central Colorado. The compiled area extends from the southern Wyoming border to the northern New Mexico border and from approximately the longitude of Denver on the east to Gunnison on the west. Data for the tephrochronology of Pleistocene volcanic ash, carbon-14, Pb-alpha, common-lead, and U-Pb determinations on uranium ore minerals have been excluded.

  13. The CDF Central Analysis Farm

    SciTech Connect

    Kim, T.H.; Neubauer, M.; Sfiligoi, I.; Weems, L.; Wurthwein, F.; /UC, San Diego

    2004-01-01

    With Run II of the Fermilab Tevatron well underway, many computing challenges inherent to analyzing large volumes of data produced in particle physics research need to be met. We present the computing model within CDF designed to address the physics needs of the collaboration. Particular emphasis is placed on current development of a large O(1000) processor PC cluster at Fermilab serving as the Central Analysis Farm for CDF. Future plans leading toward distributed computing and GRID within CDF are also discussed.

  14. [Bases of central venous catheterization].

    PubMed

    Schmalz-Ott, Stéphane; Monti, Matteo; Vollenweider, Peter

    2008-10-29

    Central venous catheterization is a frequently performed procedure in internal medicine units. Residents in training frequently share the same questions, doubts and fears about this procedure : "Should I perform a subclavian catheterization in a patient with mild thrombopenia?"; "Which site has the lesser complication rate?"; "After how long does a catheter need to be replaced?". This mini-review of the current literature tries to answer this and other questions.

  15. Celtic Sites of Central Iberia

    NASA Astrophysics Data System (ADS)

    Pérez Gutiérrez, Manuel

    This chapter concerns the astronomy practiced by Celtic peoples in some parts of central Iberia, specifically the Vetton and Celtiberian peoples, inhabitants of the so-called Late Iron Age. The construction of some elements of religion or worship was perfectly determined by geometry, topography, and especially astronomy, because their spatial orientation occurs in locations of great interest for maintaining the local calendar. The maintenance of this calendar was probably the primary objective of some of the elements studied.

  16. Central Asia Active Fault Database

    NASA Astrophysics Data System (ADS)

    Mohadjer, Solmaz; Ehlers, Todd A.; Kakar, Najibullah

    2014-05-01

    The ongoing collision of the Indian subcontinent with Asia controls active tectonics and seismicity in Central Asia. This motion is accommodated by faults that have historically caused devastating earthquakes and continue to pose serious threats to the population at risk. Despite international and regional efforts to assess seismic hazards in Central Asia, little attention has been given to development of a comprehensive database for active faults in the region. To address this issue and to better understand the distribution and level of seismic hazard in Central Asia, we are developing a publically available database for active faults of Central Asia (including but not limited to Afghanistan, Tajikistan, Kyrgyzstan, northern Pakistan and western China) using ArcGIS. The database is designed to allow users to store, map and query important fault parameters such as fault location, displacement history, rate of movement, and other data relevant to seismic hazard studies including fault trench locations, geochronology constraints, and seismic studies. Data sources integrated into the database include previously published maps and scientific investigations as well as strain rate measurements and historic and recent seismicity. In addition, high resolution Quickbird, Spot, and Aster imagery are used for selected features to locate and measure offset of landforms associated with Quaternary faulting. These features are individually digitized and linked to attribute tables that provide a description for each feature. Preliminary observations include inconsistent and sometimes inaccurate information for faults documented in different studies. For example, the Darvaz-Karakul fault which roughly defines the western margin of the Pamir, has been mapped with differences in location of up to 12 kilometers. The sense of motion for this fault ranges from unknown to thrust and strike-slip in three different studies despite documented left-lateral displacements of Holocene and late

  17. Central auditory testing and dyslexia.

    PubMed

    Welsh, L W; Welsh, J J; Healy, M P

    1980-06-01

    A group of dyslexic pupils with normal end organ function was studied by a central auditory battery to determine whether a hearing disability existed. The clinical features of dyslexia are presented with emphasis on the psychological developmental and functional disorders associated with this reading problem. The central battery of Willeford was selected as the test medium and the results of the 77 dyslexic students were compared to the normative data. The model proposed by Sparks, et al., is accepted as the mechanism for dichotic audition. Reference is made to the organic basis of reading disorders from lesion in the calcarine area to the angular gyrus. The competing sentence test, binaural fusion, rapidly alternating speech perception, and filtered speech are described in detail and are organic foundation for the study. The authors indentified a high rate of failure in this investigation. Over 50% of the dyslexic students failed two of the four tests, and each of the 77 failed at least one component. The most sensitive tests were binaural fusion and filtered speech with less variation from the norm in the remaining two components. The effect of maturation in central audition was measured in each of the four tests. The data suggest: 1. the scores are lower in the early ages in each test; 2. that rapidly alternating speech and competing sentences approach the normal range albeit somewhat delayed; and 3. that binaural fusion and filtered speech improve in score somewhat but rather moderately and never approach the normal range. Based upon the central auditory data and in conjunction with the anatomical pathways of vision, the authors suggest the site of lesion to be in the temporo-parietal cortex and the association fibers.

  18. Volcanic hazards in Central America

    USGS Publications Warehouse

    Rose, William I.; Bluth, Gregg J.S.; Carr, Michael J.; Ewert, John W.; Patino, Lina C.; Vallance, James W.

    2006-01-01

    This volume is a sampling of current scientific work about volcanoes in Central America with specific application to hazards. The papers reflect a variety of international and interdisciplinary collaborations and employ new methods. The book will be of interest to a broad cross section of scientists, especially volcanologists. The volume also will interest students who aspire to work in the field of volcano hazards mitigation or who may want to work in one of Earth’s most volcanically active areas.

  19. Central corneal thickness in children.

    PubMed

    Bradfield, Yasmin S; Melia, B Michele; Repka, Michael X; Kaminski, Brett M; Davitt, Bradley V; Johnson, David A; Kraker, Raymond T; Manny, Ruth E; Matta, Noelle S; Weise, Katherine K; Schloff, Susan

    2011-09-01

    To determine the central corneal thickness (CCT) in healthy white, African American, and Hispanic children from birth to 17 years of age and to determine whether CCT varies by age, race, or ethnicity. Prospective observational multicenter study. Central corneal thickness was measured with a handheld contact pachymeter. A total of 2079 children were included in the study, with ages ranging from birth to 17 years. Included were 807 whites, 494 Hispanics, and 474 African Americans, in addition to Asian, unknown race, and mixed-race individuals. African American children had thinner corneas on average than that of both white and Hispanic children (P < .001 for both) by approximately 20 μm. Thicker median CCT was observed with each successive year of age from age 1 to 11 years, with year-to-year differences steadily decreasing and reaching a plateau after age 11 at 573 μm in white and Hispanic children and 551 μm in African American children. For every 100 μm of thicker CCT measured, the intraocular pressure was 1.5 mm Hg higher on average (P < .001). For every diopter of increased myopic refractive error, CCT was 1 μm thinner on average (P < .001). Median CCT increases with age from 1 to 11 years, with the greatest increase present in the youngest age groups. African American children on average have thinner central corneas than white and Hispanic children, whereas white and Hispanic children demonstrate similar CCT.

  20. Neuroimaging of central breathlessness mechanisms.

    PubMed

    Pattinson, Kyle T S; Johnson, Miriam J

    2014-09-01

    Breathlessness debilitates millions of people with cardiorespiratory conditions and cancer. Symptoms correlate poorly with the objective measures of disease (e.g. spirometry). Altered brain processing of respiratory sensations may contribute to this disparity. This article summarizes how functional neuroimaging works, focussing on functional MRI (FMRI) and magnetoencephalography, how neuroimaging has shed light on the central mechanisms of breathlessness and thus how it may help target new therapies. Current understanding of central neural activity in breathlessness comes mainly from a small number of studies in healthy volunteers using models of induced acute breathlessness. Parallels with neuroimaging findings in pain and fear or anxiety have been used to interpret the neuroimaging studies of breathlessness to form hypotheses. Despite the lack of recent neuroimaging studies in breathlessness, there have been methodological advances in overcoming confounders with respiratory FMRI. In addition, developing interest in the distinction of emotional from the sensory aspects of breathlessness and the use of opioids for breathlessness has driven mechanistic understandings. Neuroimaging of breathlessness remains in its infancy. However, advances in the understanding of central perception, combined with novel neuroimaging techniques, means that we are poised to increase our understanding of the brain processes of breathlessness and their modulation.

  1. Central core of the cerebrum.

    PubMed

    Choi, Chan-Young; Han, Seong-Rok; Yee, Gi-Taek; Lee, Chae-Heuck

    2011-02-01

    The purpose of this study was to understand 3D relationships of white matter fibers and subcortical areas of gray matter in the central core. The lateral and medial aspects of 4 cerebral hemispheres were dissected, applying the fiber dissection technique under the microscope. The central core between the insula and midline includes the extreme, external, and internal capsules; claustrum; putamen; globus pallidus; caudate nucleus; amygdala; diencephalon; substantia innominata; fornix; anterior commissure; mammillothalamic tract; fasciculus retroflexus; thalamic peduncles, including optic and auditory radiations; ansa peduncularis; thalamic fasciculus; and lenticular fasciculus. It is attached to the remainder of the cerebral hemisphere by the cerebral isthmus, which is composed of white matter fibers located between the dorsolateral margin of the caudate nucleus and the full circumference of the circular sulcus of insula. The rostral fibers of the corpus callosum are included in the frontal portion of the cerebral isthmus. It is very useful for neurosurgeons to facilitate the understanding of spatial relationships and pertinent surgical approaches in and around the central core with a highly complex anatomy by using fiber dissection.

  2. The Continuing Value of Ultrastructural Observation in Central Nervous System Neoplasms in Children.

    PubMed

    Kim, Na Rae; Park, Sung-Hye

    2015-11-01

    Central nervous system (CNS) neoplasms are the second most common childhood malignancy after leukemia and the most common solid organ neoplasm in children. Diagnostic dilemmas with small specimens from CNS neoplasms are often the result of multifactorial etiologies such as frozen or fixation artifact, biopsy size, or lack of knowledge about rare or unfamiliar entities. Since the late 1950s, ultrastructural examination has been used in the diagnosis of CNS neoplasms, though it has largely been replaced by immunohistochemical and molecular cytogenetic studies. Nowadays, pathologic diagnosis of CNS neoplasms is achieved through intraoperative cytology, light microscopy, immunohistochemistry, and molecular cytogenetic results. However, the utility of electron microscopy (EM) in the final diagnosis of CNS neoplasms and investigation of its pathogenetic origin remains critical. Here, we reviewed the distinguishing ultrastructural features of pediatric CNS neoplasms and emphasize the continuing value of EM in the diagnosis of CNS neoplasms.

  3. SOFIS FTS EM test results

    NASA Astrophysics Data System (ADS)

    Soucy, Marc-Andre A.; Levesque, Luc E.; Tanii, Jun; Kawashima, Takahiro; Nakajima, Hideaki

    2003-04-01

    The Solar Occultation FTS for Inclined-orbit Satellite (SOFIS) is a solar occultation Fourier transform spectrometer developed by the Ministry of the Environment (MOE) in Japan for the Global Change Observation Mission-A1 (GCOM-A1) satellite. GCOM-A1 will be placed in a 650 km non-sun-synchronous orbit, with an inclination angle of 69 degrees. ABB-Bomem is a sub-contractor of NTSpace (NEC-Toshiba Space) for the design and manufacturing of the FTS Engineering Model of SOFIS. SOFIS measures the vertical profile of the atmospheric constituents with 0.2 cm-1 spectral resolution for the spectral range covering 3-13 μm. The atmospheric vertical resolution of SOFIS is 1 km. The target of SOFIS measurements is a global distribution of O3, HNO3, NO2, N2O, CH4, H2O, CO2, CFC-11, CFC-12, ClONO2, aerosol extinction, atmospheric pressure and temperature. NTSpace in Japan is the prime contractor of SOFIS. The spectrometer is an adapted version of the classical Michelson interferometer using an optimized optical layout and moving retro-reflectors. A solid-state laser diode operating at 1550 nm is used as metrology source of the interferometer. Its highly folded optical design results in a high performance instrument with a compact size. SOFIS FTS implements high performance control techniques to achieve outstanding speed stability of the moving mechanism. This paper describes the test activities of the SOFIS-FTS Engineering Model (EM) and preliminary results. The performances of the FTS are presented in terms of key parameters like signal-to-noise ratio, modulation efficiency and stability. Spectra acquired are shown and test methodology and analyses are presented. Lessons learned during assembly, integration and testing are described as well as improvements planned to be implemented in the Flight Model.

  4. EMS adaptation for climate change

    NASA Astrophysics Data System (ADS)

    Pan, C.; Chang, Y.; Wen, J.; Tsai, M.

    2010-12-01

    The purpose of this study was to find an appropriate scenario of pre-hospital transportation of an emergency medical service (EMS) system for burdensome casualties resulting from extreme climate events. A case of natural catastrophic events in Taiwan, 88 wind-caused disasters, was reviewed and analyzed. A sequential-conveyance method was designed to shorten the casualty transportation time and to promote the efficiency of ambulance services. A proposed mobile emergency medical center was first constructed in a safe area, but nearby the disaster area. The Center consists of professional medical personnel who process the triage of incoming patients and take care of casualties with minor injuries. Ambulances in the Center were ready to sequentially convey the casualties with severer conditions to an assigned hospital that is distant from the disaster area for further treatment. The study suggests that if we could construct a spacious and well-equipped mobile emergency medical center, only a small portion of casualties would need to be transferred to distant hospitals. This would reduce the over-crowding problem in hospital ERs. First-line ambulances only reciprocated between the mobile emergency medical center and the disaster area, saving time and shortening the working distances. Second-line ambulances were highly regulated between the mobile emergency medical center and requested hospitals. The ambulance service of the sequential-conveyance method was found to be more efficient than the conventional method and was concluded to be more profitable and reasonable on paper in adapting to climate change. Therefore, additional practical work should be launched to collect more precise quantitative data.

  5. Filter banks and the EM algorithm

    SciTech Connect

    Mair, B.A.; Carroll, R.B.; Anderson, J.M.M.

    1996-12-31

    In this paper, we present a wavelet based modification of the ML-EM algorithm for reconstructing positron emission tomography images. By using the filter bank implementation of the wavelet transform, this algorithm has the flexibility to incorporate a priori information, while maintaining the same computational complexity as the standard ML-EM algorithm. Thus, it has a significant computational advantage over usual Bayesian methods. It differs from recent wavelet-based Bayesian methods as it achieves {open_quotes}regularization{close_quotes} by an adaptive, wavelet-based method of thresholding which minimizes Stein`s Unbiased Estimate of Risk. The basic method consists of applying Donoho and Johnstone`s SureShrink wavelet denoising of the Poisson data, and then applying the standard ML-EM algorithm to the denoised data. A more elaborate method is discussed in which a wavelet denoising step is inserted after each EM iteration. This technique differs from previous smoothing techniques applied to the ML-EM algorithm since it is able to recover edges in discontinuous images.

  6. Evidence for central regulation of glucose metabolism.

    PubMed

    Carey, Michelle; Kehlenbrink, Sylvia; Hawkins, Meredith

    2013-12-06

    Evidence for central regulation of glucose homeostasis is accumulating from both animal and human studies. Central nutrient and hormone sensing in the hypothalamus appears to coordinate regulation of whole body metabolism. Central signals activate ATP-sensitive potassium (KATP) channels, thereby down-regulating glucose production, likely through vagal efferent signals. Recent human studies are consistent with this hypothesis. The contributions of direct and central inputs to metabolic regulation are likely of comparable magnitude, with somewhat delayed central effects and more rapid peripheral effects. Understanding central regulation of glucose metabolism could promote the development of novel therapeutic approaches for such metabolic conditions as diabetes mellitus.

  7. Central hypersensitivity in chronic musculoskeletal pain.

    PubMed

    Curatolo, Michele; Arendt-Nielsen, Lars

    2015-05-01

    Clinical research has consistently detected alteration in central pain processing leading to hypersensitivity. Most methods used in humans are reliable and have face validity to detect widespread central hypersensitivity. However, construct validity is difficult to investigate due to lack of gold standards. Reference values in the pain-free population have been generated, but need replication. Research on pain biomarkers that reflect specific central hypersensitivity processes is warranted. Few studies have analyzed the prognostic value of central hypersensitivity. Most medications acting at central level and some non-pharmacological approaches, including psychological interventions, are likely to attenuate central hypersensitivity.

  8. Central vascular catheter infections in a Hospital of Central Italy.

    PubMed

    Lombardi, Silvia; Scutell, Massimiliano; Felice, Valentina; Di Campli, Emanuela; Di Giulio, Mara; Cellini, Luigina

    2014-01-01

    The insertion and the permanence of central venous catheters (CVC) represent potential sources of infection contracted in hospital. The evaluation of the risk of CVC-associated infections was evaluated in a retrospective study during the period 2007-2010 in a Hospital of Central Italy. A total of 514 CVC were collected and examined by microbiological techniques and, among the examined patients, 450 CVC blood cultures were collected. Cultures were performed collecting a portion of 5-6 cm of intravenous catheters in liquid medium and spread on selective media for Gram-positive and Gram-negative bacteria and yeasts; blood specimens were obtained through peripheral venous punctures and analyzed by a commercial automated system. 308/514 (59.90%) samples were positive to the microbiological culture. Staphylococcus aureus, S. epidermidis and other coagulase negative Staphylococci (CNS) were the prevalent Gram-positive bacteria. Among Gram-negative bacteria, Enterobacteriaceae and Pseudomonaceae were the main bacteria isolated. A higher prevalence of Gram-positive bacteria was observed in Neonatal Pathology (90.90%). The Intensive Care Unit (ICU) showed 73.10% of positive cultures with 54.12% of Gram-positive isolates. Among positive blood cultures (38%), Gram-positive bacteria were the main bacteria isolated. The high prevalence of catheter-related infections requires accurate surveillance and the assumption of preventive measures in particular during catheter insertion.

  9. Processing of Cryo-EM Movie Data.

    PubMed

    Ripstein, Z A; Rubinstein, J L

    2016-01-01

    Direct detector device (DDD) cameras dramatically enhance the capabilities of electron cryomicroscopy (cryo-EM) due to their improved detective quantum efficiency (DQE) relative to other detectors. DDDs use semiconductor technology that allows micrographs to be recorded as movies rather than integrated individual exposures. Movies from DDDs improve cryo-EM in another, more surprising, way. DDD movies revealed beam-induced specimen movement as a major source of image degradation and provide a way to partially correct the problem by aligning frames or regions of frames to account for this specimen movement. In this chapter, we use a self-consistent mathematical notation to explain, compare, and contrast several of the most popular existing algorithms for computationally correcting specimen movement in DDD movies. We conclude by discussing future developments in algorithms for processing DDD movies that would extend the capabilities of cryo-EM even further. © 2016 Elsevier Inc. All rights reserved.

  10. 7 CFR 1945.35 - Special EM loan training.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... workshop and a test. (c) Objective. The basic objective of this training program is to keep State and... kit, will be used for the EM loan training meetings, and any subsequent EM loan training...

  11. 7 CFR 1945.35 - Special EM loan training.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... workshop and a test. (c) Objective. The basic objective of this training program is to keep State and... kit, will be used for the EM loan training meetings, and any subsequent EM loan training...

  12. Integrating Green Purchasing Into Your Environmental Management System (EMS)

    EPA Pesticide Factsheets

    The goal of this report is to help Federal facilities integrate green purchasing into their EMS. The intended audience includes those tasked with implementing an EMS, reducing environmental impacts, meeting green purchasing requirements.

  13. 10 CFR Appendixes E-M to Part 52 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52...

  14. 10 CFR Appendixes E-M to Part 52 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52 ...

  15. 10 CFR Appendixes E-M to Part 52 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52 ...

  16. 10 CFR Appendixes E-M to Part 52 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52 ...

  17. 10 CFR Appendixes E-M to Part 52 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false E Appendixes E-M to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Appendixes E-M to Part 52 ...

  18. Training Educational Administrators in Central America

    ERIC Educational Resources Information Center

    Bernede, Jean-Francois

    1977-01-01

    Training of educational administrators in Central America is described and evaluated and future prospects are discussed. It is recommended that the six countries of Central America cooperate to achieve educational reform. (Author/DB)

  19. Central Saudi Arabia, Persian Gulf

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This panoramic view of Central Saudi Arabia and the Persian Gulf (28.0N, 47.0E) dramatically illustrates the stark beauty of the deserts. Riyadh, the capital city, lies in the foreground, with the Persian Gulf in the middle and Iran in the background. The coastal oil terminals of Al Hufuf and Ad Dammam are also visible. Black smudges of soot from the oil fires set during the Gulf War can be seen on the sands to the north and south of Kuwait City.

  20. Centralized Storm Information System (CSIS)

    NASA Technical Reports Server (NTRS)

    Norton, C. C.

    1985-01-01

    A final progress report is presented on the Centralized Storm Information System (CSIS). The primary purpose of the CSIS is to demonstrate and evaluate real time interactive computerized data collection, interpretation and display techniques as applied to severe weather forecasting. CSIS objectives pertaining to improved severe storm forecasting and warning systems are outlined. The positive impact that CSIS has had on the National Severe Storms Forecast Center (NSSFC) is discussed. The benefits of interactive processing systems on the forecasting ability of the NSSFC are described.

  1. The central arctic caribou herd

    USGS Publications Warehouse

    Cameron, Raymond D.; Smith, Walter T.; White, Robert G.; Griffith, Brad; Douglas, David C.; Reynolds, Patricia E.; Rhode, E.B.

    2002-01-01

    From the mid-1970s through the mid-1980s, use of calving and summer habitats by Central Arctic herd caribou (Rangifer tarandus granti) declined near petroleum development infrastructure on Alaska's arctic coastal plain (Cameron et al. 1979; Cameron and Whitten 1980, Smith and Cameron 1983. Whitten and Cameron 1983a, 1985: Dau and Cameron 1986).With surface development continuing to expand westward from the Prudhoe Bay petroleum development area (Fig. 4.1), concerns arose that the resultant cumulative losses of habitat would eventually reduce productivity of the caribou herd. Specifically, reduced access of adult females to preferred foraging areas might adversely affect growth and fattening (Elison et al. 1986. Clough et al. 1987), in turn depressing calf production (Dauphiné 1976, Thomas 1982, Reimers 1983, White 1983, Eloranta and Nieminen 1986. Lenvik et al. 1988, Thomas and Kiliaan 1991) and survival (Haukioja and Salovaara 1978, Rognmo et al. 1983, Skogland 1984, Eloranta and Nieminen 1986, Adamczewski et al. 1987).Those concerns, though justified in theory, lacked empirical support. With industrial development in arctic Alaska virtually unprecedented, there was little basis for predicting the extent and duration of habitat loss, much less the secondary short- and long-term effects on the well-being of a particular caribou herd.Furthermore, despite a general acceptance that body condition and fecundity of the females are functionally related for reindeer and caribou, it seemed unlikely that any single model would apply to all subspecies of Rangifer, and perhaps not even within a subspecies in different geographic regions. We therefore lacked a complete understanding of the behavioral responses of arctic caribou to industrial development, the manner in which access to habitats might be affected, and how changes in habitat use might translate into measurable effects on fecundity and herd growth rate.Our study addressed the following objectives: 1) estimate

  2. (Centralized Reliability Data Organization (CRDO))

    SciTech Connect

    Haire, M J

    1987-04-21

    One of the primary goals of the Centralized Reliability Data Organization (CREDO) is to be an international focal point for the collection, analysis, and dissemination of liquid metal reactor (LMR) component reliability, availability, and maintainability (RAM) data. During FY-1985, the Department of Energy (DOE) entered into a Specific Memorandum of Agreement (SMA) with Japan's Power Reactor and Nuclear Fuel Development Corporation (PNC) regarding cooperative data exchange efforts. This agreement was CREDO's first step toward internationalization and represented an initial realization of the previously mentioned goal. DOE's interest in further internationalization of the CREDO system was the primary motivation for the traveler's attendance at the Reliability '87 conference.

  3. Central and Southern Florida, USA

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This oblique view documents conditions in South Florida (27.0N, 81.0W) in the aftermath of Hurricane Andrew that severly mauled south Florida on 24 Aug 92, battering Dade County with a 16.9 ft. storm surge and wind gusts of up to 169 mph. An additional feature is the band of haze running across the central portion of the state The band of air pollution has been drawn from the north by a weak cold front and was focused along the east/west axis of the front.

  4. Risk Communication Within the EM Program

    SciTech Connect

    Edelson, M.

    2003-02-26

    The U.S. Department of Energy Environmental Management program (EM) conducts the most extensive environmental remediation effort in the world. The annual EM budgets have exceeded $6,000,000,000 for approximately ten years and EM has assumed responsibility for the cleanup of the largest DOE reservations (i.e., at Hanford, Washington, Aiken, South Carolina, and Idaho Falls, Idaho) as well as the facilities at Rocky Flats, Colorado and in Ohio. Each of these sites has areas of extensive radioactive and chemical contamination, numerous surplus facilities that require decontamination and removal, while some have special nuclear material that requires secure storage. The EM program has been criticized for being ineffective (1) and has been repeatedly reorganized to address perceived shortcomings. The most recent reorganization was announced in 2001 to become effective at the beginning of the 2003 Federal Fiscal Year (i.e., October 2002). It was preceded by a ''top to bottom'' review (TTBR) of the program (2) that identified several deficiencies that were to be corrected as a result of the reorganization. One prominent outcome of the TTBR was the identification of ''risk reduction'' as an organizing principle to prioritize the activities of the new EM program. The new program also sought to accelerate progress by identifying a set of critical activities at each site that could be accelerated and result in more rapid site closure, with attendant risk, cost, and schedule benefits. This paper investigates how the new emphasis on risk reduction in the EM program has been communicated to EM stakeholders and regulators. It focuses on the Rocky Flats Environmental Technology Site (RFETS) as a case study and finds that there is little evidence for a new emphasis on risk reduction in EM communications with RFETS stakeholders. Discussions between DOE and RFETS stakeholders often refer to ''risk,'' but the word serves as a placeholder for other concepts. Thus ''risk'' communication

  5. Structural Composites With Tuned EM Chirality

    DTIC Science & Technology

    2014-12-23

    AFRL-OSR-VA-TR-2015-0018 STRUCTURAL COMPOSITES WITH TUNED EM CHIRALITY Siavouche Nemat Nasser UNIVERSITY OF CALIFORNIA SAN DIEGO Final Report 12/23...REPORT Grant/Contract  Title:        STRUCTURAL  COMPOSITES  WITH  TUNED  EM   CHIRALITY     Grant  No.:  FA9550-­‐09-­‐1...structural   composites  with   tunable   chiral   elements   has   produced   some   impressive   results   in   the

  6. Lessons Learned: Integrating EMS and Environmental Compliance Auditing

    DTIC Science & Technology

    2009-05-06

    audit an EMS against the – ISO 14001 :2004 Standard – Installation’s own commitments and procedures established under their EMS (i.e. are they doing...what they said they would do?) – Army Policy • Findings are documented in a Word report (external audits) • ISO 14001 conformance is determined by...regulatory requirements • EMS Findings – Conformance: management system conforms to ISO 14001 standard – Major Nonconformance: EMS is missing element

  7. A Military Strategy for Central Asia

    DTIC Science & Technology

    2006-05-31

    Policy Toward Kazakhstan,” in Thinking Strategically : The Major Powers, Kazakhstan, and the Central Asian Nexus, ed. Robert Legvold (Cambridge, MA: MIT...Sherman W. “The Strategic Challenge of Kazakhstan and Inner Asia” In Thinking Strategically . The Major Powers, Kazakhstan, and the Central Asian Nexus, ed...Legvold, Robert, ed. “Great Power Stakes in Central Asia” In Thinking Strategically . The Major Powers, Kazakhstan, and the Central Asian Nexus, 1-38

  8. Distributed trace using central performance counter memory

    DOEpatents

    Satterfield, David L; Sexton, James C

    2013-10-22

    A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.

  9. Distributed trace using central performance counter memory

    DOEpatents

    Satterfield, David L.; Sexton, James C.

    2013-01-22

    A plurality of processing cores, are central storage unit having at least memory connected in a daisy chain manner, forming a daisy chain ring layout on an integrated chip. At least one of the plurality of processing cores places trace data on the daisy chain connection for transmitting the trace data to the central storage unit, and the central storage unit detects the trace data and stores the trace data in the memory co-located in with the central storage unit.

  10. Government Venture Capital: Centralized or Decentralized Execution

    DTIC Science & Technology

    2007-12-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT Government Venture Capital: Centralized or...DATE December 2007 3. REPORT TYPE AND DATES COVERED MBA Professional Report 4. TITLE AND SUBTITLE Government Venture Capital: Centralized or...these questions is the following issue: Should the DoD manage VC in a centralized or decentralized manner? B. OBJECTIVES The purpose of this MBA

  11. 20 CFR 346.1 - Central register.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Central register. 346.1 Section 346.1... RAILROAD HIRING § 346.1 Central register. (a) The Board shall maintain a central register of railroad... employment. The register shall indicate which of those employees claims a first right of hire. (b)...

  12. 49 CFR 71.6 - Central zone.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Central zone. 71.6 Section 71.6 Transportation Office of the Secretary of Transportation STANDARD TIME ZONE BOUNDARIES § 71.6 Central zone. The third zone, the central standard time zone, includes that part of the United States that is west of the...

  13. Central State University: Phase III Report

    ERIC Educational Resources Information Center

    Ohio Board of Regents, 2013

    2013-01-01

    This document is the final report on Central State University's implementation of Section 371 of Ohio Amended Substitute House Bill 153. Implementation of Phase I action items required that deliverables and timelines be shifted to give Central State the best opportunity for early success. In Phase II, Central State responded aggressively to a…

  14. 34 CFR 303.162 - Central directory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Central directory. 303.162 Section 303.162 Education... Central directory. Each application must include information and assurances demonstrating to the satisfaction of the Secretary that the State has developed a central directory of information that meets the...

  15. 20 CFR 346.1 - Central register.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Central register. 346.1 Section 346.1 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT RAILROAD HIRING § 346.1 Central register. (a) The Board shall maintain a central register of...

  16. Low clouds in central California

    NASA Image and Video Library

    2017-09-28

    Low clouds filled California’s Central Valley in late January, 2015. Such winter fog is considered a common phenomenon, and can be so dense that it snarls traffic, causes fender-benders, and can make symptoms worse in those with respiratory disease. At the same time, the moist winter fog helps keep temperatures low in the rich agricultural region by reflecting sunlight and keeping the ground from warming, which helps keep the abundant fruit and nut trees dormant, allowing for bountiful harvests. Scientific studies have reported that winter fogs (also called Thule fogs) are occurring less frequently in the Central Valley. One study, by Dennis Baldocchi and Eric Waller, was published in May, 2014. It finds that since 1981 the number of fog days between November and February has decreased by 46 percent. The severe drought that California has experienced in recent years may also have decreased the number of fog events even more since 2012. The Moderate Resolution Imaging Spectroradiometer (MODIS) aboard NASA’s Terra satellite captured this true-color image on January 24, 2015. Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  17. Hazardous pesticides in Central America.

    PubMed

    Wesseling, C; Aragón, A; Castillo, L; Corriols, M; Chaverri, F; de la Cruz, E; Keifer, M; Monge, P; Partanen, T J; Ruepert, C; van Wendel de Joode, B

    2001-01-01

    Pesticides are an extensively documented occupational and environmental hazard in Central America. Yet, severe problems persist. Toxic pesticide use in the Region increased during 1985-1999. High exposure levels and ineffectiveness of personal protective equipment evidence the difficulties for risk reduction. Acute poisonings remain a severe problem. Delayed and/or long-lasting health effects include dermatoses, cancer, and genotoxic, neurotoxic, and respiratory effects. The use of hazardous pesticides persists through deficiencies in government-driven assessment and risk management; excessive focus on regional harmonization; short-term economic interests; strong links between industry and governments; aggressive marketing; weak trade unions; and failure of universities to reach decision makers. Regulation based on local data is lacking. An agreement of the Ministries of Health for restricting the most toxic pesticides in Central America has potential for progress. The most effective way to reduce risk is to greatly reduce pesticide use. Actions needed include development of multidisciplinary strategies for local studies on health and environmental impact of pesticides; development of sustainable nonchemical agricultural technologies; evaluation of interventions; extending and sharing of expertise within the Region; strengthening of unions and communities; and redefining the role of industry toward development of safer products, with responsible marketing and reliable information.

  18. [Central venous blood gas analysis].

    PubMed

    Marano, Marco; D'Amato, Anna; Guiotto, Giovanna; Schiraldi, Fernando

    2015-01-01

    The hemodialysis might interfere with patients hemodynamic, as the technique allows a sophisticated game with extra and intravascular fluids. As the cardiocirculatory response could sometimes be unpredictable, it is interesting to collect valuable information by reaching a deep understanding of the tissue metabolism which is mirrored by the blood gas analysis of variations in arterial and central venous blood samples. Particularly interesting are the time course variations of the central venous hemoglobin saturation (ScvO2), which are directly related to the patient with O2-demand as well as to the O2-Delivery (DO2). The ScvO2 is determined by four parameters (cardiac output, Hb concentration, arterial Hb saturation and O2 consumption): If the fluids subtraction during dialysis was about to determine an occult hypoperfusion, the ScvO2 reduction would be a timely warning sign to be considered. Moreover, while the normal veno-arterial PCO2 difference is 2-4 mmHg, whenever a mismatch between O2-demand and DO2arise, a larger v-aPCO2 difference should be observed.

  19. Primary hypersomnias of central origin.

    PubMed

    Frenette, Eric; Kushida, Clete A

    2009-09-01

    Hypersomnia is a frequently encountered symptom in clinical practice. The cardinal manifestation is inappropriate daytime sleepiness, common to all types of hypersomnias. Hypersomnias of central origin are a rare cause of excessive daytime sleepiness, much rarer than the hypersomnia related to other pathologies, such as sleep-disordered breathing. Narcolepsy, with or without cataplexy, remains the most well studied of the primary hypersomnias. Although recognized more than a century ago, it was not until the end of the 20th century that major breakthroughs led to a better understanding of the disease, with hope of more specific therapies. The authors review the major aspects of this disorder, including the newer treatment modalities. Idiopathic hypersomnia is also part of the primary hypersomnias. Although difficult to diagnose, certain peculiarities stand out to help us differentiate it from the more commonly seen narcolepsy. The recurrent hypersomnias, particularly the Kleine-Levin syndrome, will be discussed. This rare disorder has been studied more closely in the last few years with abundant epidemiologic data assembled through literature and worldwide case reviews. Understanding the primary central hypersomnias warrants a thorough look from the original description, as well as a peek at the future, while more efficacious diagnostic and therapeutic interventions are currently being developed.

  20. Precipitation chemistry in central Amazonia

    NASA Technical Reports Server (NTRS)

    Andreae, M. O.; Talbot, R. W.; Berresheim, H.; Beecher, K. M.

    1990-01-01

    Rain samples from three sites in central Amazonia were collected over a period of 6 weeks during the 1987 wet season and analyzed for ionic species and dissolved organic carbon. A continuous record of precipitation chemistry and amount was obtained at two of these sites, which were free from local or regional pollution, for a time period of over 1 month. The volume-weighted mean concentrations of most species were found to be about a factor of 5 lower during the wet season compared with previous results from the dry season. Only sodium, potassium, and chloride showed similar concentrations in both seasons. When the seasonal difference in rainfall amount is taken into consideration, the deposition fluxes are only slightly lower for most species during the wet season than during the dry season, again with the exception of chloride, potassium, and sodium. Sodium and chloride are present in the same ratio as in sea salt; rapid advection of air masses of marine origin to the central Amazon Basin during the wet season may be responsible for the observed higher deposition flux of these species. Statistical analysis suggests that sulfate is, to a large extent, of marine (sea salt and biogenic) origin, but that long-range transport of combustion-derived aerosols also makes a significant contribution to sulfate and nitrate levels in Amazonian rain. Organic acid concentrations in rain were responsible for a large fraction of the observed precipitation acidity; their concentration was strongly influenced by gas/liquid interactions.

  1. Central East Pacific Flight Routing

    NASA Technical Reports Server (NTRS)

    Grabbe, Shon; Sridhar, Banavar; Kopardekar, Parimal; Cheng, Nadia

    2006-01-01

    With the introduction of the Federal Aviation Administration s Advanced Technology and Oceanic Procedures system at the Oakland Oceanic Center, a level of automation now exists in the oceanic environment to potentially begin accommodating increased user preferred routing requests. This paper presents the results of an initial feasibility assessment which examines the potential benefits of transitioning from the fixed Central East Pacific routes to user preferred routes. As a surrogate for the actual user-provided routing requests, a minimum-travel-time, wind-optimal dynamic programming algorithm was developed and utilized in this paper. After first describing the characteristics (e.g., origin airport, destination airport, vertical distribution and temporal distribution) of the westbound flights utilizing the Central East Pacific routes on Dec. 14-16 and 19-20, the results of both a flight-plan-based simulation and a wind-optimal-based simulation are presented. Whereas the lateral and longitudinal distribution of the aircraft trajectories in these two simulations varied dramatically, the number of simulated first-loss-of-separation events remained relatively constant. One area of concern that was uncovered in this initial analysis was a potential workload issue associated with the redistribution of traffic in the oceanic sectors due to thc prevailing wind patterns.

  2. Central exclusive production at RHIC

    DOE PAGES

    Adamczyk, Leszek; Guryn, Włodek; Turnau, Jacek

    2014-11-10

    The present status and future plans of the physics program of Central Exclusive Production (CEP) at RHIC are described. The measurements are based on the detection of the forward protons from the Double Pomeron Exchange (DPE) process in the Roman Pot system and of the recoil system of charged particles from the DPE process measured in the STAR experiment’s Time Projection Chamber (TPC). The data described here were taken using polarized proton-proton collisions at ps = 200 GeV. The preliminary spectra of two pion and four pion invariant mass reconstructed by STAR TPC in central region of pseudo-rapidity | |more » < 1, are presented. Near future plans to take data with the current system at center-of-mass energy ps = 200 GeV and plans to upgrade the forward proton tagging sys- tem are presented. Also a possible addition of the Roman Pots to the sPHENIX detector is discussed.« less

  3. The phylogeny of central chemoreception.

    PubMed

    Milsom, W K

    2010-10-31

    Respiratory chemoreceptors responsive to changes in CO(2)/H(+) appear to be present in all vertebrates from fish to birds and mammals. They appear to have arisen first in the periphery sensitive to the external environment. Thus, in most fish CO(2)/H(+) chemoreceptors reside primarily in the gills and respond to changes in aquatic rather than arterial P(CO)₂ . In the air-breathing tetrapods (amphibians, mammals, reptiles and birds), the branchial arches regress developmentally and the derivatives of the branchial arteries are now exclusively internal. The receptors associated with these arteries now sense only arterial (not environmental) P(CO)₂/pH . Central CO(2)/H(+) chemoreception also appears to have arisen with the advent of air breathing, presumably as a second line of defense. These receptors may have arisen multiple times in association with several (but not all) of the independent origins of air breathing in fishes. There is strong evidence for multiple central sites of CO(2)/H(+) sensing, at least in amphibians and mammals, suggesting that it may not only have originated multiple times in different species but also multiple times within a single species.

  4. Occupational health in Central America.

    PubMed

    Wesseling, Catharina; Aragón, Aurora; Morgado, Hugo; Elgstrand, Kaj; Hogstedt, Christer; Partanen, Timo

    2002-01-01

    The 12.4 million economically active population (EAP) of the seven Central American countries includes a large informal sector. Social security covers only 14-60%. No surveillance of occupational safety and health (OSH) hazards or accidents exists. Extrapolating the incidence of occupational accidents among insured Costa Rican workers to the Central American EAP yields two million accidents yearly, still a gross underestimate. Occupational diseases are underreported, misdiagnosed, and not recognized as such. A number of regional OSH programs aim at modernization of the labor administrations and address the formal sector, in particular textile maquila, in connection with free trade agreements. The weak role of the ministries of health is expected to strengthen under the Pan American Health Organization OSH program. Employers largely influence new policies. Workers' influence on OSH policies has been weak, with only about 10% unionization rate and scarce resources and OSH knowledge. Informal workers, however, are getting organized. OSH research is underdeveloped and not linked to policy making. Construction, agriculture, and general un/underemployment are considered priorities for intervention. The informal sector needs to be included in national and regional OSH policies. Regional collaboration and international development support are of strategic importance to achieve sustainable improvement in OSH.

  5. Central vascular catheters and infections.

    PubMed

    Dioni, Elisabetta; Franceschini, Renata; Marzollo, Roberto; Oprandi, Daniela; Chirico, Gaetano

    2014-03-01

    Newborn infants in critical conditions require a permanent intra-venous line to allow for the administration of fluids, parenteral nutrition and drugs. The use of central venous catheters, however, is associated with an increased risk of infections, leading to prolongation of length of stay and higher hospitalization costs, particularly in extremely preterm infants. Dwell time is a significant factor for complications, with a predicted risk of catheter related infections of about 4 per 1000 catheter-days. To reduce the incidence of complications, several requirements must be met, including adequate staff and resources to provide education, training, and quality improvement programs, within a culture of communication and teamwork. Rigorous reporting schedule on line care and the implementation of unique bundle elements, the use of health care failure mode and effect analysis, the judicious use of antibiotics through an antimicrobial stewardship strategy, the application of specific antifungal prophylaxis are among the most effective interventions, while the addition of heparin to parenteral solution, or the use of antibiotic plus heparin lock therapy are under evaluation. Nursing assistance plays a fundamental role in managing central venous lines and in reducing or preventing the incidence of infection, by the application of several complex professional strategies.

  6. Exploration potential of Central Europe

    SciTech Connect

    Krueger, W.C. )

    1991-03-01

    Because of governmental changes an entire region of Central Europe has received exploration scrutiny not possible during the past 40-50 years. This entire area - Hungary, Czechoslovakia, Romania, Bulgaria, Yugoslavia, Albania, Poland, and East Germany - is tectonically related. Yugoslavia, although not under the same restrictions, is also considered in the same tectonic setting. Therefore, these countries can be expected to reflect some of the same stratigraphy, source rock, reservoir, trap and field types, and production history. Much of the region can be considered frontier while other parts mature. Production from all is about 55,000 T/D, 380,000 BO/D and 63.1 Bm{sup 3}/yr, 2,203 Bft{sup 3}/yr. Major source rocks have been identified as Tertiary-Oligocene, Miocene-Mesozoic, Triassic, Jurassic, and Cretaceous. Carboniferous coal sequences are considered source for the Permian. The East European platform and Tethyian plates are the foundation of the Central Europe states. Plate collisions during the late Mesozoic and into the Tertiary affected the Carpathian, Balkans, Dinarides, and Helenide Mountain chains. Mesozoic and Tertiary foredeep deposits have been proven productive from normal-, thrust-, and wrench-faulted anticlinal structures. Paleozoic, Mesozoic erosional remnants, and Tertiary lacustrine and deltaic stratigraphic deposits are the major productive reservoirs in the Pannonian basin. Permian shelf and reefal deposits are found in such areas as the Permian Shelf in Eastern Germany and Poland. Reefal plays may be found in Bulgaria and Romania offshore.

  7. Central Equatorial Pacific Experiment (CEPEX)

    SciTech Connect

    Not Available

    1993-01-01

    The Earth's climate has varied significantly in the past, yet climate records reveal that in the tropics, sea surface temperatures seem to have been remarkably stable, varying by less than a few degrees Celsius over geologic time. Today, the large warm pool of the western Pacific shows similar characteristics. Its surface temperature always exceeds 27[degree]C, but never 31[degree]C. Heightened interest in this observation has been stimulated by questions of global climate change and the exploration of stabilizing climate feedback processes. Efforts to understand the observed weak sensitivity of tropical sea surface temperatures to climate forcing has led to a number of competing ideas about the nature of this apparent thermostat. Although there remains disagreement on the processes that regulate tropical sea surface temperature, most agree that further progress in resolving these differences requires comprehensive field observations of three-dimensional water vapor concentrations, solar and infrared radiative fluxes, surface fluxes of heat and water vapor, and cloud microphysical properties. This document describes the Central Equatorial Pacific Experiment (CEPEX) plan to collect such observations over the central equatorial Pacific Ocean during March of 1993.

  8. Salinity modeling by remote sensing in central and southern Iraq

    NASA Astrophysics Data System (ADS)

    Wu, W.; Mhaimeed, A. S.; Platonov, A.; Al-Shafie, W. M.; Abbas, A. M.; Al-Musawi, H. H.; Khalaf, A.; Salim, K. A.; Chrsiten, E.; De Pauw, E.; Ziadat, F.

    2012-12-01

    Salinization, leading to a significant loss of cultivated land and crop production, is one of the most active land degradation phenomena in the Mesopotamian region in Iraq. The objectives of this study (under the auspices of ACIAR and Italian Government) are to investigate the possibility to use remote sensing technology to establish salinity-sensitive models which can be further applied to local and regional salinity mapping and assessment. Case studies were conducted in three pilot sites namely Musaib, Dujaila and West Garraf in the central and southern Iraq. Fourteen spring (February - April), seven June and four summer Landsat ETM+ images in the period 2009-2012, RapidEye data (April 2012), and 95 field EM38 measurements undertaken in this spring and summer, 16 relevant soil laboratory analysis result (Dujaila) were employed in this study. The procedure we followed includes: (1) Atmospheric correction using FLAASH model; (2) Multispectral transformation of a set of vegetation and non-vegetation indices such as GDVI (Generalized Difference Vegetation Index), NDVI (Normalized Difference Vegetation Index), EVI (Enhanced Vegetation Index), SAVI (Soil Adjusted Vegetation Index), SARVI (Soil Adjusted and Atmospherically Resistant Vegetation Index), NDII (Normalized Difference Infrared Index), Principal Components and surface temperature (T); (3) Derivation of the spring maximum (Musaib) and annual maximum (Dujaila and West Garraf) value in each pixel of each index of the observed period to avoid problems related to crop rotation (e.g. fallow) and the SLC-Off gaps in ETM+ images; (4) Extraction of the values of each vegetation and non-vegetation index corresponding to the field sampling locations (about 3 to 5 controversial samples very close to the roads or located in fallow were excluded); and (5) Coupling remote sensing indices with the available EM38 and soil electrical conductivity (EC) data using multiple linear least-square regression model at the confidence

  9. Comparing an Atomic Model or Structure to a Corresponding Cryo-electron Microscopy Image at the Central Axis of a Helix.

    PubMed

    Zeil, Stephanie; Kovacs, Julio; Wriggers, Willy; He, Jing

    2017-01-01

    Three-dimensional density maps of biological specimens from cryo-electron microscopy (cryo-EM) can be interpreted in the form of atomic models that are modeled into the density, or they can be compared to known atomic structures. When the central axis of a helix is detectable in a cryo-EM density map, it is possible to quantify the agreement between this central axis and a central axis calculated from the atomic model or structure. We propose a novel arc-length association method to compare the two axes reliably. This method was applied to 79 helices in simulated density maps and six case studies using cryo-EM maps at 6.4-7.7 Å resolution. The arc-length association method is then compared to three existing measures that evaluate the separation of two helical axes: a two-way distance between point sets, the length difference between two axes, and the individual amino acid detection accuracy. The results show that our proposed method sensitively distinguishes lateral and longitudinal discrepancies between the two axes, which makes the method particularly suitable for the systematic investigation of cryo-EM map-model pairs.

  10. Causal mechanisms of seismo-EM phenomena during the 1965–1967 Matsushiro earthquake swarm

    PubMed Central

    Enomoto, Yuji; Yamabe, Tsuneaki; Okumura, Nobuo

    2017-01-01

    The 1965–1967 Matsushiro earthquake swarm in central Japan exhibited two unique characteristics. The first was a hydro-mechanical crust rupture resulting from degassing, volume expansion of CO2/water, and a crack opening within the critically stressed crust under a strike-slip stress. The other was, despite the lower total seismic energy, the occurrence of complexed seismo-electromagnetic (seismo-EM) phenomena of the geomagnetic intensity increase, unusual earthquake lights (EQLs) and atmospheric electric field (AEF) variations. Although the basic rupture process of this swarm of earthquakes is reasonably understood in terms of hydro-mechanical crust rupture, the associated seismo-EM processes remain largely unexplained. Here, we describe a series of seismo-EM mechanisms involved in the hydro-mechanical rupture process, as observed by coupling the electric interaction of rock rupture with CO2 gas and the dielectric-barrier discharge of the modelled fields in laboratory experiments. We found that CO2 gases passing through the newly created fracture surface of the rock were electrified to generate pressure-impressed current/electric dipoles, which could induce a magnetic field following Biot-Savart’s law, decrease the atmospheric electric field and generate dielectric-barrier discharge lightning affected by the coupling effect between the seismic and meteorological activities. PMID:28322263

  11. Causal mechanisms of seismo-EM phenomena during the 1965-1967 Matsushiro earthquake swarm

    NASA Astrophysics Data System (ADS)

    Enomoto, Yuji; Yamabe, Tsuneaki; Okumura, Nobuo

    2017-03-01

    The 1965-1967 Matsushiro earthquake swarm in central Japan exhibited two unique characteristics. The first was a hydro-mechanical crust rupture resulting from degassing, volume expansion of CO2/water, and a crack opening within the critically stressed crust under a strike-slip stress. The other was, despite the lower total seismic energy, the occurrence of complexed seismo-electromagnetic (seismo-EM) phenomena of the geomagnetic intensity increase, unusual earthquake lights (EQLs) and atmospheric electric field (AEF) variations. Although the basic rupture process of this swarm of earthquakes is reasonably understood in terms of hydro-mechanical crust rupture, the associated seismo-EM processes remain largely unexplained. Here, we describe a series of seismo-EM mechanisms involved in the hydro-mechanical rupture process, as observed by coupling the electric interaction of rock rupture with CO2 gas and the dielectric-barrier discharge of the modelled fields in laboratory experiments. We found that CO2 gases passing through the newly created fracture surface of the rock were electrified to generate pressure-impressed current/electric dipoles, which could induce a magnetic field following Biot-Savart’s law, decrease the atmospheric electric field and generate dielectric-barrier discharge lightning affected by the coupling effect between the seismic and meteorological activities.

  12. Causal mechanisms of seismo-EM phenomena during the 1965-1967 Matsushiro earthquake swarm.

    PubMed

    Enomoto, Yuji; Yamabe, Tsuneaki; Okumura, Nobuo

    2017-03-21

    The 1965-1967 Matsushiro earthquake swarm in central Japan exhibited two unique characteristics. The first was a hydro-mechanical crust rupture resulting from degassing, volume expansion of CO2/water, and a crack opening within the critically stressed crust under a strike-slip stress. The other was, despite the lower total seismic energy, the occurrence of complexed seismo-electromagnetic (seismo-EM) phenomena of the geomagnetic intensity increase, unusual earthquake lights (EQLs) and atmospheric electric field (AEF) variations. Although the basic rupture process of this swarm of earthquakes is reasonably understood in terms of hydro-mechanical crust rupture, the associated seismo-EM processes remain largely unexplained. Here, we describe a series of seismo-EM mechanisms involved in the hydro-mechanical rupture process, as observed by coupling the electric interaction of rock rupture with CO2 gas and the dielectric-barrier discharge of the modelled fields in laboratory experiments. We found that CO2 gases passing through the newly created fracture surface of the rock were electrified to generate pressure-impressed current/electric dipoles, which could induce a magnetic field following Biot-Savart's law, decrease the atmospheric electric field and generate dielectric-barrier discharge lightning affected by the coupling effect between the seismic and meteorological activities.

  13. Do earthquakes generate EM signals?

    NASA Astrophysics Data System (ADS)

    Walter, Christina; Onacha, Stephen; Malin, Peter; Shalev, Eylon; Lucas, Alan

    2010-05-01

    study areas, large swarms of earthquakes were located very close to the electromagnetic coils. This abstract focuses on the data from the Wairakei area. Preliminary data analysis has been carried out by band pass filtering and removing of the harmonics of the 50 Hz power line frequency. The initial results clearly show that electromagnetic signals accompany the seismic P and S waves (coseismic signal). Further data analysis involves the extraction of the seismoelectric signal generated at the onset of the earthquake and at interfaces from the coseismic signal and other ‘noise' sources. This processing step exhibits a major challenge in seismoelectric data processing. Unlike in other studies we measured the EM field and the seismic field at one location. Therefore the seismoelectric wave travelling at the speed of light cannot be determined as easily in the arrival times as when an array of coils is used. This makes the determination of the origin time much more difficult. Hence other processing techniques need to be explored.

  14. EMS response to an airliner crash.

    PubMed

    Dasgupta, Shuvra; French, Simone; Williams-Johnson, Jean; Hutson, Rhonda; Hart, Nicole; Wong, Mark; Williams, Eric; Espinosa, Kurdell; Maycock, Celeste; Edwards, Romayne; McCartney, Trevor; Cawich, Shamir; Crandon, Ivor

    2012-06-01

    This report of an aircraft crash at a major airport in Kingston, Jamaica examines the response of the local Emergency Medical Services (EMS). Factors that impacted the response are discussed, and the need for more disaster simulation exercises is highlighted. The objective of this case report was to document the response of EMS personnel to the crash of American Airlines Flight 331, and to utilize the information to examine and improve the present protocol. While multiple errors can occur during a mass-casualty event, these can be reduced by frequent simulation exercises during which various personnel practice and learn designated roles. Efficient triage, proper communication, and knowledge of the roles are important in ensuring the best possible outcome. While the triage system and response of the EMS personnel were effective for this magnitude of catastrophe, more work is needed in order to meet predetermined standards. Ways in which this can be overcome include: (1) hosting more disaster simulation exercises; (2) encouraging more involvement with first responders; and (3) strengthening the links in the local EMS system. Vigorous public education must be instituted and maintained.

  15. Central Solenoid Insert Technical Specification

    SciTech Connect

    Martovetsky, Nicolai N; Smirnov, Alexandre

    2011-09-01

    The US ITER Project Office (USIPO) is responsible for the ITER central solenoid (CS) contribution to the ITER project. The Central Solenoid Insert (CSI) project will allow ITER validation the appropriate lengths of the conductors to be used in the full-scale CS coils under relevant conditions. The ITER Program plans to build and test a CSI to verify the performance of the CS conductor. The CSI is a one-layer solenoid with an inner diameter of 1.48 m and a height of 4.45 m between electric terminal ends. The coil weight with the terminals is approximately 820 kg without insulation. The major goal of the CSI is to measure the temperature margin of the CS under the ITER direct current (DC) operating conditions, including determining sensitivity to load cycles. Performance of the joints, ramp rate sensitivity, and stability against thermal or electromagnetic disturbances, electrical insulation, losses, and instrumentation are addressed separately and therefore are not major goals in this project. However, losses and joint performance will be tested during the CSI testing campaign. The USIPO will build the CSI that will be tested at the Central Solenoid Model Coil (CSMC) Test Facility at the Japan Atomic Energy Agency (JAEA), Naka, Japan. The industrial vendors (the Suppliers) will report to the USIPO (the Company). All approvals to proceed will be issued by the Company, which in some cases, as specified in this document, will also require the approval of the ITER Organization. Responsibilities and obligations will be covered by respective contracts between the USIPO, called Company interchangeably, and the industrial Prime Contractors, called Suppliers. Different stages of work may be performed by more than one Prime Contractor, as described in this specification. Technical requirements of the contract between the Company and the Prime Contractor will be covered by the Fabrication Specifications developed by the Prime Contractor based on this document and approved by

  16. Anatomical basis of central venous catheter fracture.

    PubMed

    Jensen, Mark O

    2008-03-01

    Central venous catheter fracture is a rare complication of long-term indwelling subclavian venous access. Subclavian vein access has been the recommended approach for placing central venous catheters. The anatomical landmark method for subclavian access remains a highly successful and nonequipment-dependent method for rapid central access. More recently, the internal jugular vein approach has emerged as the preferred route for long-term central venous access. However, variations in internal jugular vein anatomy make the landmark method less reliable. Use of two-dimensional real-time ultrasound during internal jugular vein access is associated with better success, a lower complication rate, and faster access. A case of central venous catheter fracture initiated an internal review of long-term central venous access procedures. We have converted to a predominantly internal jugular vein approach. This case report and literature review may assist other physicians and institutions in re-evaluating long-term central venous access protocols.

  17. Geology of central Lake Michigan.

    USGS Publications Warehouse

    Wood, R.J.; Paull, R.A.; Wolosin, C.A.; Friedel, R.J.

    1981-01-01

    The geology beneath central Lake Michigan is interpreted from a synthesis of 1,700 km of continuous seismic reflection profile data, bathymetry, grab samples, and onshore surface and subsurface information. The map of unconsolidated sediment (primarily Pleistocene) shows thicknesses ranging from 180 m in a steep- walled, northeast-trending valley to less than 10 m over a mid-lake topographic high. These are the dominant features developed on the gently eastward-dipping Paleozoic rocks along this part of the western flank of the Michigan basin. Two structural-stratigraphic cross sections of the study area were constructed. The cross sections, grab samples and other information were used to construct a Paleozoic geologic map. Speculations are made about the petroleum potential beneath Lake Michigan. -from Authors

  18. Central solar-energy receiver

    DOEpatents

    Not Available

    1981-10-27

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan is described. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  19. [Suppurative thrombophlebitis central venous catheterization].

    PubMed

    Ramos Martínez, A; Sánchez Romero, I; Saura Lorente, P A; Parajón Díaz, A

    2008-06-01

    Suppurative thrombophlebitisis a very infrequent complication of the central venous catheterization. The majority of the cases are produced by species of staphylococci. A 22-year-old colombian-woman, student, without toxic habits was admitted because of temporary left astrocytoma (grade II). Nine days after implementing a catheter in the right subclavian vein she presented high fever (39.5 degrees C), shivers, progressive right side neck swelling and odinofagia. She had leukocytosis (26,300 cells/microl) and normal cerebrospinal fluid. After withdrawing the catheter, Staphylococcus aureus was isolated in the tip of the catheter and in four bottles of blood cultures. A neck CT demonstrated expansion and absence of contrast in the right internal jugular vein. The patient evolved satisfactorily with cloxacillin, gentamycin and low molecular weight heparin.

  20. Peripherally Inserted Central Catheters and Hemodialysis Outcomes.

    PubMed

    McGill, Rita L; Ruthazer, Robin; Meyer, Klemens B; Miskulin, Dana C; Weiner, Daniel E

    2016-08-08

    Use of peripherally inserted central catheters has expanded rapidly, but the consequences for patients who eventually require hemodialysis are undefined. Our national, population-based analysis included 33,918 adult Medicare beneficiaries from the US Renal Data System who initiated hemodialysis with central venous catheters as their sole vascular access in 2010 and 2011. We used linked Medicare claims to identify peripherally inserted central catheter exposures and evaluate the associations of peripherally inserted central catheter placement with transition to working arteriovenous fistulas or grafts and patient survival using a Cox model with time-dependent variables. Among 33,918 individuals initiating hemodialysis with a catheter as sole access, 12.6% had received at least one peripherally inserted central catheter. Median follow-up was 404 days (interquartile range, 103-680 days). Among 6487 peripherally inserted central catheters placed, 3435 (53%) were placed within the 2 years before hemodialysis initiation, and 3052 (47%) were placed afterward. Multiple peripherally inserted central catheters were placed in 30% of patients exposed to peripherally inserted central catheters. Recipients of peripherally inserted central catheters were more likely to be women and have comorbid diagnoses and less likely to have received predialysis nephrology care. After adjustment for clinical and demographic factors, peripherally inserted central catheters placed before or after hemodialysis initiation were independently associated with lower likelihoods of transition to any working fistula or graft (hazard ratio for prehemodialysis peripherally inserted central catheter, 0.85; 95% confidence interval, 0.79 to 0.91; hazard ratio for posthemodialysis peripherally inserted central catheter, 0.81; 95% confidence interval, 0.73 to 0.89). Peripherally inserted central catheter placement was common and associated with adverse vascular access outcomes. Recognition of potential long

  1. Unsettled weather across central Australia

    NASA Image and Video Library

    2017-09-27

    In late July 2013, a low pressure system off Australia’s southeast coast and moist onshore winds combined to create unsettled weather across central Australia – and a striking image of a broad cloud band across the stark winter landscape. The Moderate Resolution Imaging Spectroradiometer (MODIS) aboard NASA’s Terra satellite captured this true-color image on July 22 at 01:05 UTC (10:35 a.m. Australian Central Standard Time). To the west of the low pressure trough the skies are clear and dry. To the east, the broad band of bright white clouds obscures the landscape. The system brought wind, precipitation and cooler temperatures to the region. The same day as MODIS captured this image, the Naval Research Lab (NRL) published an edition of the Global Storm Tracker (GST), which gave a world-wide view of the low-pressure systems across the world. This tracker shows the entire cloud band across Australia, as well as the location of the low pressure system. A good view of the Storm Tracker is provided by Red Orbit at: www.redorbit.com/media/uploads/2013/07/072213-weather-003... Credit: NASA/GSFC/Jeff Schmaltz/MODIS Land Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  2. Wooden Calendars from Central Rhodopes

    NASA Astrophysics Data System (ADS)

    Koleva, V.

    2008-10-01

    Four wooden calendars from the village of Polkovnik Serafimovo, Smolyan region, in the Central Rhodopes are presented here, and three of them - for the first time. The shape and size, the kind of the signs and structure of the calendar record bear the characteristic features of the rest of the Bulgarian wooden calendars. The short notches on the edges represent the days of the year in the Julian (solar) calendar. The special signs on the sides mark the fixed festivals of the Orthodox Church calendar and are also influenced by the local tradition. The type of the signs confirms that the wooden sticks belong to the group of calendars from the Central Rhodopes. According to the beginning date of the calendar record on the sticks, two of the calendars are of the April (May) or October (November) type which corresponds to the very popular economic division of the year in the folk calendar into two periods -- warm and cold. The other two sticks, which are very similar to each other, make an exception in this respect among the rest of the Bulgarian wooden calendars. The months are divided into four groups (seasons) on each of the four edges of the stick (only one calendar from Burgas region has the same structure). The most interesting thing about the two sticks is that this is the only case among all known Bulgarian calendars that the beginning of the calendar record coincides with the beginning of the civil year on 1st January (January type) like some wooden calendars from Western Europe. Nowadays it is getting harder and harder to find wooden calendars in Bulgaria and in the neighbouring Balkan countries. The thorough knowledge about them could be helpful in various scientific fields, e.g. history of religion, ethnology, history of astronomy and mathematics, as well as semiotics.

  3. Navigating 3D electron microscopy maps with EM-SURFER.

    PubMed

    Esquivel-Rodríguez, Juan; Xiong, Yi; Han, Xusi; Guang, Shuomeng; Christoffer, Charles; Kihara, Daisuke

    2015-05-30

    The Electron Microscopy DataBank (EMDB) is growing rapidly, accumulating biological structural data obtained mainly by electron microscopy and tomography, which are emerging techniques for determining large biomolecular complex and subcellular structures. Together with the Protein Data Bank (PDB), EMDB is becoming a fundamental resource of the tertiary structures of biological macromolecules. To take full advantage of this indispensable resource, the ability to search the database by structural similarity is essential. However, unlike high-resolution structures stored in PDB, methods for comparing low-resolution electron microscopy (EM) density maps in EMDB are not well established. We developed a computational method for efficiently searching low-resolution EM maps. The method uses a compact fingerprint representation of EM maps based on the 3D Zernike descriptor, which is derived from a mathematical series expansion for EM maps that are considered as 3D functions. The method is implemented in a web server named EM-SURFER, which allows users to search against the entire EMDB in real-time. EM-SURFER compares the global shapes of EM maps. Examples of search results from different types of query structures are discussed. We developed EM-SURFER, which retrieves structurally relevant matches for query EM maps from EMDB within seconds. The unique capability of EM-SURFER to detect 3D shape similarity of low-resolution EM maps should prove invaluable in structural biology.

  4. Remedial investigation Phase 2 supplemental work plan for the Hanford Site 1100-EM-1 Operable Unit

    SciTech Connect

    Not Available

    1991-09-01

    The 1100 Area, the central warehousing, vehicle maintenance, and transportation operations center for the Hanford Site, was designated an (NPL) National Priorities List site in July 1989. This NPL site was divided into four operable units, and the first equipment maintenance operable unit, 1100-EM-1, was assigned the highest priority. The following summary focuses on the major issues related to contaminant sources, meteorology, surface hydrology, geology, pedology, hydrogeology, and ecology. The 110-EM-1 Phase 1 R1 report recommended further investigation at six waste management units assigned to or within the operable unit. 1100-1 (Battery Acid Pit)--an unlined dry sump, or french drain, used for the disposal of waste acid from vehicle batteries; 1100-2 (Paint and solvent Pit)--a former sand and gravel pit subsequently used for the disposal of construction debris and, reportedly, waste paints, thinner, and solvents; 1100-4 (Antifreeze Tank Site)--The site of a former underground storage tank used for the disposal of waste vehicle antifreeze; UN-1100-6 (Discolored Soil Site)--the location of an apparent disposal event onto the ground surface involving a container of organic waste liquids; Horn Rapids Landfill--a solid waste facility used primarily for the disposal of office and construction waste and the burning of classified documents; asbestos, sewage sludge, fly ash, and, potentially, drums of unidentified organic liquids alleged to be disposed at this location; and Ephemeral Pool--the location of 1100 Area parking lot runoff accumulation during infrequent, high-intensity precipitation events. This remedial investigation supplemental work plan details the efforts for final characterization of the 1100-EM-1 Operable Unit that will provide data to be used for the evaluation of remedial operations in the Phase 3 1100-EM-1 feasibility study. 19 refs., 28 figs., 2 tabs.

  5. The association between EMS workplace safety culture and safety outcomes.

    PubMed

    Weaver, Matthew D; Wang, Henry E; Fairbanks, Rollin J; Patterson, Daniel

    2012-01-01

    Prior studies have highlighted wide variation in emergency medical services (EMS) workplace safety culture across agencies. To determine the association between EMS workplace safety culture scores and patient or provider safety outcomes. We administered a cross-sectional survey to EMS workers affiliated with a convenience sample of agencies. We recruited these agencies from a national EMS management organization. We used the EMS Safety Attitudes Questionnaire (EMS-SAQ) to measure workplace safety culture and the EMS Safety Inventory (EMS-SI), a tool developed to capture self-reported safety outcomes from EMS workers. The EMS-SAQ provides reliable and valid measures of six domains: safety climate, teamwork climate, perceptions of management, working conditions, stress recognition, and job satisfaction. A panel of medical directors, emergency medical technicians and paramedics, and occupational epidemiologists developed the EMS-SI to measure self-reported injury, medical errors and adverse events, and safety-compromising behaviors. We used hierarchical linear models to evaluate the association between EMS-SAQ scores and EMS-SI safety outcome measures. Sixteen percent of all respondents reported experiencing an injury in the past three months, four of every 10 respondents reported an error or adverse event (AE), and 89% reported safety-compromising behaviors. Respondents reporting injury scored lower on five of the six domains of safety culture. Respondents reporting an error or AE scored lower for four of the six domains, while respondents reporting safety-compromising behavior had lower safety culture scores for five of the six domains. Individual EMS worker perceptions of workplace safety culture are associated with composite measures of patient and provider safety outcomes. This study is preliminary evidence of the association between safety culture and patient or provider safety outcomes.

  6. The association between EMS workplace safety culture and safety outcomes

    PubMed Central

    Weaver, Matthew D.; Wang, Henry E.; Fairbanks, Rollin J.; Patterson, Daniel

    2012-01-01

    Objective Prior studies have highlighted wide variation in EMS workplace safety culture across agencies. We sought to determine the association between EMS workplace safety culture scores and patient or provider safety outcomes. Methods We administered a cross-sectional survey to EMS workers affiliated with a convenience sample of agencies. We recruited these agencies from a national EMS management organization. We used the EMS Safety Attitudes Questionnaire (EMS-SAQ) to measure workplace safety culture and the EMS Safety Inventory (EMS-SI), a tool developed to capture self-reported safety outcomes from EMS workers. The EMS-SAQ provides reliable and valid measures of six domains: safety climate, teamwork climate, perceptions of management, perceptions of working conditions, stress recognition, and job satisfaction. A panel of medical directors, paramedics, and occupational epidemiologists developed the EMS-SI to measure self-reported injury, medical errors and adverse events, and safety-compromising behaviors. We used hierarchical linear models to evaluate the association between EMS-SAQ scores and EMS-SI safety outcome measures. Results Sixteen percent of all respondents reported experiencing an injury in the past 3 months, four of every 10 respondents reported an error or adverse event (AE), and 90% reported safety-compromising behaviors. Respondents reporting injury scored lower on 5 of the 6 domains of safety culture. Respondents reporting an error or AE scored lower for 4 of the 6 domains, while respondents reporting safety-compromising behavior had lower safety culture scores for 5 of 6 domains. Conclusions Individual EMS worker perceptions of workplace safety culture are associated with composite measures of patient and provider safety outcomes. This study is preliminary evidence of the association between safety culture and patient or provider safety outcomes. PMID:21950463

  7. Accuracy of EMS Trauma Transport Destination Plans in North Carolina.

    PubMed

    Moss, Chailee; Cowden, Christopher S; Atterton, Laurie Meyer; Arasaratnam, Meredith H; Fernandez, Antonio R; Evarts, Jeff S; Barrier, Brian; Lerner, E Brooke; Mann, N Clay; Lohmeier, Chad; Shofer, Frances S; Brice, Jane H

    2015-01-01

    Abstract Objective. Planning for time-sensitive injury may allow emergency medical services (EMS) systems to more accurately triage patients meeting accepted criteria to facilities most capable of providing life-saving treatment. In 2010, North Carolina (NC) implemented statewide Trauma Triage and Destination Plans (TTDPs) in all 100 of North Carolina's county-defined EMS systems. Each system was responsible for identifying the specific destination hospitals with appropriate resources to treat trauma patients. We sought to characterize the accuracy of their hospital designations. Methods. In this cross-sectional study, we collected TTDPs for each county-defined EMS system, including their assigned hospital capabilities (i.e., trauma center or community hospital). We conducted a survey with each EMS system to determine how their TTDP was constructed and maintained, as well as with each TTDP-designated hospital to verify their capabilities. We determined the accuracy of the EMS assigned hospital designations by comparing them to the hospital's reported capabilities. Results. The 100 NC EMS systems provided 380 designations for 112 hospitals. TTDPs were created by EMS administrators and medical directors, with only 55% of EMS systems engaging a hospital representative in the plan creation. Compared to the actual hospital capabilities, 97% of the EMS TTDP designations were correct. Twelve hospital designations were incorrect and the majority (10) overestimated hospital capabilities. Of the 100 EMS systems, 7 misclassified hospitals in their TTDP. EMS systems that did not verify their local hospitals' capabilities during TTDP development were more likely to incorrectly categorize a hospital's capabilities (p = 0.001). Conclusions. A small number of EMS systems misclassified hospitals in their TTDP, but most plans accurately reflected hospital capabilities. Misclassification occurred more often in systems that did not consult local hospitals prior to developing their

  8. Approximating centrality in evolving graphs: toward sublinearity

    NASA Astrophysics Data System (ADS)

    Priest, Benjamin W.; Cybenko, George

    2017-05-01

    The identification of important nodes is a ubiquitous problem in the analysis of social networks. Centrality indices (such as degree centrality, closeness centrality, betweenness centrality, PageRank, and others) are used across many domains to accomplish this task. However, the computation of such indices is expensive on large graphs. Moreover, evolving graphs are becoming increasingly important in many applications. It is therefore desirable to develop on-line algorithms that can approximate centrality measures using memory sublinear in the size of the graph. We discuss the challenges facing the semi-streaming computation of many centrality indices. In particular, we apply recent advances in the streaming and sketching literature to provide a preliminary streaming approximation algorithm for degree centrality utilizing CountSketch and a multi-pass semi-streaming approximation algorithm for closeness centrality leveraging a spanner obtained through iteratively sketching the vertex-edge adjacency matrix. We also discuss possible ways forward for approximating betweenness centrality, as well as spectral measures of centrality. We provide a preliminary result using sketched low-rank approximations to approximate the output of the HITS algorithm.

  9. Central Gain Control in Tinnitus and Hyperacusis

    PubMed Central

    Auerbach, Benjamin D.; Rodrigues, Paulo V.; Salvi, Richard J.

    2014-01-01

    Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders. PMID:25386157

  10. Development of passive volcanic margins of the Central Atlantic and initial opening of ocean

    NASA Astrophysics Data System (ADS)

    Melankholina, E. N.; Sushchevskaya, N. M.

    2015-01-01

    Geological and geophysical data on the Central Atlantic are discussed in order to elucidate the tectonic setting of the initial magmatic activity, rifting, and breakup resulting in the origination of Mesozoic ocean. The structural, magmatic, and historical aspects of the problem are considered. It has been established that the initial dispersed rifting and low-capacity magmatism at proximal margins was followed by the migration of the process toward the central part of region with the formation of distal zones and the development of vigorous magmmatism, further breakup of the lithosphere and ocean opening. Magmatism, its sources, and the features of newly formed magmatic crust at both the rifting and breakup stages of margin development are discussed and compared with subsequent spreading magmatism. Sr, Nd, and Pb isotopic compositions show that the magmatic evolution of the Central Atlantic proximal margins bears the features of two enriched components, one of which is related to the EM-1 source, developing only at the North American margin. Another enriched component typical of the province as a whole is related to the EM-2 source. To a lesser extent, this component is expressed in igneous rocks of Guyana, which also bear the signature of the MORB-type depleted source typical of spreading tholeiites in the Atlantic Ocean. Similar conditions are assumed for subsequent magmatism at the distal margins and for the early spreading basalts in the adjacent Atlantic belt, which also contain a small admixture of enriched material. A comparison of the magmatism at the margins of Central and North Atlantic reveals their specificity distinctly expressed in isotopic compositions of igneous rocks. In contrast to the typical region of the North Atlantic, the immediate melting of the enriched lithospheric source without the participation of plume-related melts is reconstructed for the proximal margins of the Central Atlantic. At the same time, decompression and melting in the

  11. What Do They Want from Us? A Survey of EM Program Directors on EM Application Criteria

    PubMed Central

    King, Kevin; Kass, Dara

    2017-01-01

    Introduction Although a relatively young specialty, emergency medicine (EM) is popular among medical students and is one of the most competitive large specialties. Consequently, students increasingly seek more opportunity to differentiate themselves from their colleagues by pursuing more clerkships at the cost of taking out additional loans: this despite the fact that those who match in EM typically do so in their top three choices. We sought to ascertain what factors EM program directors seek in their typical candidate. Methods We recruited EM program directors via the Council of Emergency Medicine Residency Directors email listserv to participate in an anonymous survey regarding the United States Medical Licensing Examination (USMLE), the number of standardized letters of evaluation (SLOE), and the number of EM rotations during the fourth year. Results 135 respondents completed the anonymous survey: 59% of respondents stated their program did not have a minimum USMLE Step 1 score, but 39% reported a minimum score of 210 or higher; 95% of programs do not require Step 2 to grant an interview, but 46% require it to place the student on the rank list; 80% require only one EM rotation to grant an interview and none require more than two; 95% of programs will accept two SLOEs for both application and rank list placement. Conclusion For the typical EM applicant, there is likely little benefit to performing more than two rotations and obtaining more than two SLOEs. Students can defer USMLE Step 2 but must complete it by the time rank lists are due. Our study was limited by the anonymity of the survey, and comments by the respondents revealed the questions did not account for some nuances programs apply to their application review process. PMID:28116023

  12. Anisotropy Studies in Central Greece

    NASA Astrophysics Data System (ADS)

    Kaviris, G.; Papadimitriou, P.; Makropoulos, K.

    2007-12-01

    The Gulf of Corinth, located in Central Greece, is a tectonic graben characterized by high seismicity level. GPS measurements indicate extension of the Gulf in an approximately N-S direction, with a rate of 10 to 15 mm/year. The southern part of the Gulf is dominated by the presence of large active normal faults in an almost E-W direction, dipping north, resulting to the subsidence of the central part of the graben. Analysis of data recorded by the Cornet network, which is the permanent network of the University of Athens, revealed the existence of an anisotropic upper crust at the eastern part of the Gulf of Corinth. Anisotropy was also observed at the western part of Corinth Gulf, using data recorded by a temporary seismological network installed in the area. Furthermore, shear wave splitting analysis was performed in the region of Attica (to the NE of the Gulf) that hosts Athens, the capital of Greece, using aftershocks of the 1999 Athens earthquake (Mw=6.0) that caused 143 fatalities. The methods used for the determination of the splitting parameters are the polarization vector as a function of time (polarigram) and the hodogram. For each selected event the direction of polarization of the fast shear wave, the delay between the two split shear waves and the polarization of the source were measured. Concerning both parts of the Gulf of Corinth, the obtained mean values of anisotropy vary between N90° and N142°. In the region of Attica the mean values of the anisotropy direction of all stations vary between N95° and N100°, almost parallel to the azimuth of the Parnitha fault. The time delay between the split shear waves vary between 0.020s and 0.130s. The obtained anisotropy measurements are in agreement with the extensive dilatancy anisotropy (EDA) model, since the direction of anisotropy is independent from the event-station azimuth and perpendicular to the direction of extension. ACKNOWLEDGMENTS The present study was co-funded by the European Social Fund

  13. ITER Central Solenoid Module Fabrication

    SciTech Connect

    Smith, John

    2016-09-23

    The fabrication of the modules for the ITER Central Solenoid (CS) has started in a dedicated production facility located in Poway, California, USA. The necessary tools have been designed, built, installed, and tested in the facility to enable the start of production. The current schedule has first module fabrication completed in 2017, followed by testing and subsequent shipment to ITER. The Central Solenoid is a key component of the ITER tokamak providing the inductive voltage to initiate and sustain the plasma current and to position and shape the plasma. The design of the CS has been a collaborative effort between the US ITER Project Office (US ITER), the international ITER Organization (IO) and General Atomics (GA). GA’s responsibility includes: completing the fabrication design, developing and qualifying the fabrication processes and tools, and then completing the fabrication of the seven 110 tonne CS modules. The modules will be shipped separately to the ITER site, and then stacked and aligned in the Assembly Hall prior to insertion in the core of the ITER tokamak. A dedicated facility in Poway, California, USA has been established by GA to complete the fabrication of the seven modules. Infrastructure improvements included thick reinforced concrete floors, a diesel generator for backup power, along with, cranes for moving the tooling within the facility. The fabrication process for a single module requires approximately 22 months followed by five months of testing, which includes preliminary electrical testing followed by high current (48.5 kA) tests at 4.7K. The production of the seven modules is completed in a parallel fashion through ten process stations. The process stations have been designed and built with most stations having completed testing and qualification for carrying out the required fabrication processes. The final qualification step for each process station is achieved by the successful production of a prototype coil. Fabrication of the first

  14. Isolation and distribution of endomorphins in the central nervous system.

    PubMed

    Zadina, James E

    2002-07-01

    Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, EM-1) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2, EM-2) have the highest affinity and selectivity for the mu-opioid receptor (MOP-R) of all known mammalian opioids. They were isolated from bovine and human brain, and are structurally distinct from the other endogenous opioids. Both EM-1 and EM-2 have potent antinociceptive activity in a variety of animal models of acute, neuropathic and allodynic pain. They regulate cellular signaling processes in a manner consistent with MOP-R-mediated effects. The EMs are implicated in the natural modulation of pain by extensive data localizing EM-like immunoreactivity (EM-LI) near MOP-Rs in several regions of the nervous system known to regulate pain. These include the primary afferents and their terminals in the spinal cord dorsal horn, where EM-2 is well-positioned to modulate pain in its earliest stages of perception. In a nerve-injury model of chronic pain, a loss of spinal EM2-LI occurs concomitant with the onset of chronic pain. The distribution of the EMs in other areas of the nervous system is consistent with a role in the modulation of diverse functions, including autonomic, neuroendocrine and reward functions as well as modulation of responses to pain and stress. Unlike several other mu opioids, the threshold dose of EM-1 for analgesia is well below that for respiratory depression. In addition, rewarding effects of EM-1 can be separated from analgesic effects. These results indicate a favorable therapeutic profile of EM-1 relative to other mu opioids. Thus, the pharmacology and distribution of EMs provide new avenues both for therapeutic development and for understanding the neurobiology of opioids.

  15. Central Diabetes Insipidus presenting with manic symptoms.

    PubMed

    Sachdeva, Jasmine Kaur; Chalana, Harsh

    2011-09-01

    Central Diabetes Insipidus mostly presents with polydipsia and polyuria but may also present with confusion, psychosis, seizure or coma. We present a case of Central Diabetes Insipidus presenting with manic symptoms. A 21 year old Indian male had Central Diabetes Insipidus, which was confirmed by water deprivation test. He presented to our hospital with full blown manic symptoms meeting the ICD 10 criteria. He was managed with intranasal Desmopressin, water restriction and Olanzapine. In contrary to routine psychiatric patients which may present with psychogenic polydipsia or Central Diabetes Insipidus patients presenting in delirium or psychosis, our case presents a unique example of Central Diabetes Insipidus presenting with manic symptoms. It hints about a relationship between a common pathway for Central Diabetes Insipidus and mood disorders which needs further research. Diencephalon has already been the focus of attention for several researchers but no concrete evidence is available yet. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. Properties of the Central American cold surge

    NASA Technical Reports Server (NTRS)

    Mcguirk, James P.; Reding, Philip J.; Zhang, Yuxia

    1993-01-01

    The Central American cold surge (CACS) is a frontal incursion from the United States into Central America and resembles the East Asian cold surge. They occur more frequently than analyzed by NMC or by published results, based on our observations between 1979 and 1990. Climatology and structure are quantified, based on surface and upper air stations throughout Central America and satellite products from GOES visible and infrared sensors and SSM/I precipitable water and rain rate sensors.

  17. The economics of central billing offices.

    PubMed

    Woodcock, E; Nguyen, L

    2000-01-01

    The anticipation of economies of scale in physician billing has led many medical practices to consolidate their billing operations. This article analyzes these economies of scale, comparing performance indicators from centralized and decentralized operations. While consolidation provides compliance, control and information, diseconomies of scale can exist in the centralized receivables management process. The authors conclude that physician practices should consider a hybrid approach to billing, thus reaping the benefits of both centralization and decentralization.

  18. A central theory of biology.

    PubMed

    Torday, John S

    2015-07-01

    The history of physiologic cellular-molecular interrelationships can be traced all the way back to the unicellular state by following the pathway formed by lipids ubiquitously accommodating calcium homeostasis, and its consequent adaptive effects on oxygen uptake by cells, tissues and organs. As a result, a cohesive, mechanistically integrated view of physiology can be formulated by recognizing the continuum comprising conception, development, physiologic homeostasis and death mediated by soluble growth factor signaling. Seeing such seemingly disparate processes as embryogenesis, chronic disease and dying as the gain and subsequent loss of cell-cell signaling provides a novel perspective for physiology and medicine. It is emblematic of the self-organizing, self-referential nature of life, starting from its origins. Such organizing principles obviate the pitfalls of teleologic evolution, conversely providing a way of resolving such seeming dichotomies as holism and reductionism, genotype and phenotype, emergence and contingence, proximate and ultimate causation in evolution, cells and organisms. The proposed approach is scale-free and predictive, offering a Central Theory of Biology.

  19. Conductivity Anomalies in Central Europe

    NASA Astrophysics Data System (ADS)

    Neska, Anne

    2016-01-01

    This paper is a review of studies which, by applying the magnetotelluric, geomagnetic deep sounding, and magnetovariational sounding methods (the latter refers to usage of the horizontal magnetic tensor), investigate Central Europe for zones of enhanced electrical conductivity. The study areas comprise the region of the Trans-European Suture Zone (i.e. the south Baltic region and Poland), the North German Basin, the German and Czech Variscides, the Pannonian Basin (Hungary), and the Polish, Slovakian, Ukrainian, and Romanian Carpathians. This part of the world is well investigated in terms of data coverage and of the density of published studies, whereas the certainty that the results lead to comprehensive interpretations varies within the reviewed literature. A comparison of spatially coincident or adjacent studies reveals the important role that the data coverage of a distinct conductivity anomaly plays for the consistency of results. The encountered conductivity anomalies are understood as linked to basin sediments, asthenospheric upwelling, large differences in lithospheric age, and—this concerns most of them, which all concentrate in the middle crust—tectonic boundaries that developed during all mountain building phases that have taken place on the continent.

  20. [Aniseikonia of central serous chorioretinopathy].

    PubMed

    Hisada, H; Awaya, S

    1992-03-01

    Central serous chorioretinopathy (CRS) is one of the typical diseases that accompany micropsia. However very little is known about micropsia of CRS, because of the difficulty to measure "aniseikonia" in terms of micropsia. Aniseikonia in 65 cases of CRS was measured quantitatively by Awaya's New Aniseikonia Tests (NAT). The tests were performed at two different distances of 40 cm (visual angle: 6 degrees) and 20 cm (12 degrees) and under 4 meridians of the halfmoon on NAT, horizontal, 45 degrees, vertical and 135 degrees, respectively. The mean value of aniseikonia under each testing condition was as follows: 6 degrees horizontal -3.13%, 45 degrees -2.56%, vertical -2.13%, 135 degrees -2.57%, 12 degrees; horizontal -1.38%, 45 degrees -1.69%, vertical -1.84%, 135 degrees -1.50%. At 6 degrees aniseikonia is larger in the horizontal meridian than in the vertical with statistical significance (t-test, p less than 0.05), while at 12 degrees aniseikonia is smaller than at 6 degrees and shows no particular tendency in terms of meridian. The phenomenon observed at 6 degrees may be what is called "oriented metamorphopsia".

  1. A Central Theory of Biology

    PubMed Central

    Torday, John S.

    2015-01-01

    The history of physiologic cellular–molecular interrelationships can be traced all the way back to the unicellular state by following the pathway formed by lipids ubiquitously accommodating calcium homeostasis, and its consequent adaptive effects on oxygen uptake by cells, tissues and organs. As a result, a cohesive, mechanistically integrated view of physiology can be formulated by recognizing the continuum comprising conception, development, physiologic homeostasis and death mediated by soluble growth factor signaling. Seeing such seemingly disparate processes as embryogenesis, chronic disease and dying as the gain and subsequent loss of cell–cell signaling provides a novel perspective for physiology and medicine. It is emblematic of the self-organizing, self-referential nature of life, starting from its origins. Such organizing principles obviate the pitfalls of teleologic evolution, conversely providing a way of resolving such seeming dichotomies as holism and reductionism, genotype and phenotype, emergence and contingence, proximate and ultimate causation in evolution, cells and organisms. The proposed approach is scale-free and predictive, offering a Central Theory of Biology. PMID:25911556

  2. Geology of central Lake Michigan

    SciTech Connect

    Wold, R.J.; Paull, R.A.; Wolosin, C.A.; Friedel, R.J.

    1981-09-01

    The geology beneath Lake Michigan between 43/sup 0/00' and 44/sup 0/00'N and between 86/sup 0/30' and 87/sup 0/40' W is interpreted from a synthesis of 1,700 km of continuous seismic reflection profile data, bathymetry, grab samples, and onshore surface and subsurface information. The continuous seismic reflection profiles and bathymetry provided information for maps of unconsolidated sediment thickness and Paleozoic bedrock topography. Two structural-stratigraphic cross sections of the study area were constructed by utilizing a composite subsurface-surface section for eastern Wisconsin and two control wells in western Michigan. The cross sections, grab samples previously described in the literature, the bedrock topographic map, and published maps were used to construct a Paleozoic geologic map for central Lake Michigan. Rocks from Middle Silurian through Early Mississippian age form subcrops beneath the study area, whereas rocks of Early Silurian, Ordovician, and Late Cambrian age are present at greater depth. The Upper Cambrian rocks unconformably overlie Precambrian igneous and metamorphic rocks. The structural-stratigraphic cross sections also allow speculation about the petroleum potential beneath Lake Michigan. The possibility of oil occurrences within the Silurian is enhanced by major east-west facies changes, and other horizons with promise are present in Devonian and Ordovician rocks. Although Michigan and Wisconsin laws currently prohibit petroleum exploration in Lake Michigan, it is an area with future potential.

  3. Central neural pathways for thermoregulation

    PubMed Central

    Morrison, Shaun F.; Nakamura, Kazuhiro

    2010-01-01

    Central neural circuits orchestrate a homeostatic repertoire to maintain body temperature during environmental temperature challenges and to alter body temperature during the inflammatory response. This review summarizes the functional organization of the neural pathways through which cutaneous thermal receptors alter thermoregulatory effectors: the cutaneous circulation for heat loss, the brown adipose tissue, skeletal muscle and heart for thermogenesis and species-dependent mechanisms (sweating, panting and saliva spreading) for evaporative heat loss. These effectors are regulated by parallel but distinct, effector-specific neural pathways that share a common peripheral thermal sensory input. The thermal afferent circuits include cutaneous thermal receptors, spinal dorsal horn neurons and lateral parabrachial nucleus neurons projecting to the preoptic area to influence warm-sensitive, inhibitory output neurons which control thermogenesis-promoting neurons in the dorsomedial hypothalamus that project to premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, that descend to provide the excitation necessary to drive thermogenic thermal effectors. A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus neurons controlling cutaneous vasoconstriction. PMID:21196160

  4. Maximal switchability of centralized networks

    NASA Astrophysics Data System (ADS)

    Vakulenko, Sergei; Morozov, Ivan; Radulescu, Ovidiu

    2016-08-01

    We consider continuous time Hopfield-like recurrent networks as dynamical models for gene regulation and neural networks. We are interested in networks that contain n high-degree nodes preferably connected to a large number of N s weakly connected satellites, a property that we call n/N s -centrality. If the hub dynamics is slow, we obtain that the large time network dynamics is completely defined by the hub dynamics. Moreover, such networks are maximally flexible and switchable, in the sense that they can switch from a globally attractive rest state to any structurally stable dynamics when the response time of a special controller hub is changed. In particular, we show that a decrease of the controller hub response time can lead to a sharp variation in the network attractor structure: we can obtain a set of new local attractors, whose number can increase exponentially with N, the total number of nodes of the nework. These new attractors can be periodic or even chaotic. We provide an algorithm, which allows us to design networks with the desired switching properties, or to learn them from time series, by adjusting the interactions between hubs and satellites. Such switchable networks could be used as models for context dependent adaptation in functional genetics or as models for cognitive functions in neuroscience.

  5. Towards a centralized Grid Speedometer

    NASA Astrophysics Data System (ADS)

    Dzhunov, I.; Andreeva, J.; Fajardo, E.; Gutsche, O.; Luyckx, S.; Saiz, P.

    2014-06-01

    Given the distributed nature of the Worldwide LHC Computing Grid and the way CPU resources are pledged and shared around the globe, Virtual Organizations (VOs) face the challenge of monitoring the use of these resources. For CMS and the operation of centralized workflows, the monitoring of how many production jobs are running and pending in the Glidein WMS production pools is very important. The Dashboard Site Status Board (SSB) provides a very flexible framework to collect, aggregate and visualize data. The CMS production monitoring team uses the SSB to define the metrics that have to be monitored and the alarms that have to be raised. During the integration of CMS production monitoring into the SSB, several enhancements to the core functionality of the SSB were required; They were implemented in a generic way, so that other VOs using the SSB can exploit them. Alongside these enhancements, there were a number of changes to the core of the SSB framework. This paper presents the details of the implementation and the advantages for current and future usage of the new features in SSB.

  6. Primary central nervous system lymphoma.

    PubMed

    Pels, Hendrik; Schlegel, Uwe

    2006-07-01

    There is no class I evidence for any therapeutic option in primary central nervous system lymphoma (PCNSL). When possible, patients should be included in clinical trials. The role of surgery is restricted to stereotactic biopsy in order to gain material for histopathologic diagnosis. Radiotherapy alone is associated with a median survival of no more than 1.5 years; cure is exceptional. However, in patients aged younger than 60 years, cure is the therapeutic aim. Polychemotherapy based on high-dose methotrexate with deferred radiation results in long-term survival in most of these patients and possibly cure in a substantial fraction of these patients. With regard to chemotherapy in PCNSL, the following must be considered: 1) the most efficient drug in PCNSL is methotrexate at a dosage of at least 1.5 g/m(2) per single dose; 2) methotrexate alone will lead to complete remission in only some patients, whereas the combination of methotrexate with other drugs is more efficient; and 3) the value of additional intraventricular chemotherapy and the necessity of "consolidation" radiotherapy after response to chemotherapy are not yet defined. For patients aged older than 60 years, no curative regimen with acceptable toxicity has yet been established. The combination of radiotherapy with methotrexate-based chemotherapy leads to severe long-term neurotoxic sequelae, ie, cognitive dysfunction, in most older patients and in some patients aged younger than 60 years.

  7. Towards a centralized Grid Speedometer

    SciTech Connect

    Dzhunov, I.; Andreeva, J.; Fajardo, E.; Gutsche, O.; Luyckx, S.; Saiz, P.

    2014-01-01

    Given the distributed nature of the Worldwide LHC Computing Grid and the way CPU resources are pledged and shared around the globe, Virtual Organizations (VOs) face the challenge of monitoring the use of these resources. For CMS and the operation of centralized workflows, the monitoring of how many production jobs are running and pending in the Glidein WMS production pools is very important. The Dashboard Site Status Board (SSB) provides a very flexible framework to collect, aggregate and visualize data. The CMS production monitoring team uses the SSB to define the metrics that have to be monitored and the alarms that have to be raised. During the integration of CMS production monitoring into the SSB, several enhancements to the core functionality of the SSB were required, They were implemented in a generic way, so that other VOs using the SSB can exploit them. Alongside these enhancements, there were a number of changes to the core of the SSB framework. This paper presents the details of the implementation and the advantages for current and future usage of the new features in SSB.

  8. Central-Monitor Software Module

    NASA Technical Reports Server (NTRS)

    Bachelder, Aaron; Foster, Conrad

    2005-01-01

    One of the software modules of the emergency-vehicle traffic-light-preemption system of the two preceding articles performs numerous functions for the central monitoring subsystem. This module monitors the states of all units (vehicle transponders and intersection controllers): It provides real-time access to the phases of traffic and pedestrian lights, and maps the positions and states of all emergency vehicles. Most of this module is used for installation and configuration of units as they are added to the system. The module logs all activity in the system, thereby providing information that can be analyzed to minimize response times and optimize response strategies. The module can be used from any location within communication range of the system; with proper configuration, it can also be used via the Internet. It can be integrated into call-response centers, where it can be used for alerting emergency vehicles and managing their responses to specific incidents. A variety of utility subprograms provide access to any or all units for purposes of monitoring, testing, and modification. Included are "sniffer" utility subprograms that monitor incoming and outgoing data for accuracy and timeliness, and that quickly and autonomously shut off malfunctioning vehicle or intersection units.

  9. Children in Central America: Victims of War.

    ERIC Educational Resources Information Center

    Ronstrom, Anitha

    1989-01-01

    Discusses the armed conflicts in Central America and their influence on civilian populations. Discusses the psychosocial consequences and therapeutic considerations of warfare, displacement and refuge for children. (RJC)

  10. Central poststroke pain: A systematic review.

    PubMed

    Singer, Jonathan; Conigliaro, Alyssa; Spina, Elizabeth; Law, Susan W; Levine, Steven R

    2017-06-01

    Background Physical, psychological, and/or social impairment can result after a stroke and can be exacerbated by pain. One type of pain after stroke, central poststroke pain, is believed to be due to primary central nervous system mechanisms. Estimated prevalence of central poststroke pain ranges widely from 8% to 55% of stroke patients, suggesting a difficulty in reliably, accurately, and consistently identifying central poststroke pain. This may be due to the absence of a generally accepted definition. Aim We aimed to clarify the role of thalamic strokes and damage to the spinothalamic pathway in central poststroke pain patients. Also, we aimed to gain a current understanding of anatomic substrates, brain imaging, and treatment of central poststroke pain. Summary of review Two independent reviewers identified 10,144 publications. Based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, we extracted data from 23 papers and categorized the articles' aims into four sections: somatosensory deficits, pathway stimulation, clinical trials, and brain imaging. Conclusions Our systematic review suggests that damage to the spinothalamic pathway is associated with central poststroke pain and this link could provide insights into mechanisms and treatment. Moreover, historical connection of strokes in the thalamic region of the brain and central poststroke pain should be reevaluated as many studies noted that strokes in other regions of the brain have high occurrence of central poststroke pain as well.

  11. Central cell confinement in MFTF-B

    SciTech Connect

    Jong, R.A.

    1981-05-05

    The point code TANDEM has been used to survey the range of plasma parameters which can be attained in MFTF-B. The code solves for the electron and ion densities and temperatures in the central cell, yin-yang, barrier, and A-cell regions as well as the plasma potential in each region. In these studies, the A-cell sloshing ion beams were fixed while the neutral beams in the yin-yang and central cell, the gas feed in the central cell, and the applied ECRH power ..beta.., central cell ion density and temperature, and the confining potential are discussed.

  12. Central blood pressure and chronic kidney disease

    PubMed Central

    Ohno, Yoichi; Kanno, Yoshihiko; Takenaka, Tsuneo

    2016-01-01

    In this review, we focused on the relationship between central blood pressure and chronic kidney diseases (CKD). Wave reflection is a major mechanism that determines central blood pressure in patients with CKD. Recent medical technology advances have enabled non-invasive central blood pressure measurements. Clinical trials have demonstrated that compared with brachial blood pressure, central blood pressure is a stronger risk factor for cardiovascular (CV) and renal diseases. CKD is characterized by a diminished renal autoregulatory ability, an augmented direct transmission of systemic blood pressure to glomeruli, and an increase in proteinuria. Any elevation in central blood pressure accelerates CKD progression. In the kidney, interstitial inflammation induces oxidative stress to handle proteinuria. Oxidative stress facilitates atherogenesis, increases arterial stiffness and central blood pressure, and worsens the CV prognosis in patients with CKD. A vicious cycle exists between CKD and central blood pressure. To stop this cycle, vasodilator antihypertensive drugs and statins can reduce central blood pressure and oxidative stress. Even in early-stage CKD, mineral and bone disorders (MBD) may develop. MBD promotes oxidative stress, arteriosclerosis, and elevated central blood pressure in patients with CKD. Early intervention or prevention seems necessary to maintain vascular health in patients with CKD. PMID:26788468

  13. The E-MS Algorithm: Model Selection with Incomplete Data.

    PubMed

    Jiang, Jiming; Nguyen, Thuan; Rao, J Sunil

    2015-04-04

    We propose a procedure associated with the idea of the E-M algorithm for model selection in the presence of missing data. The idea extends the concept of parameters to include both the model and the parameters under the model, and thus allows the model to be part of the E-M iterations. We develop the procedure, known as the E-MS algorithm, under the assumption that the class of candidate models is finite. Some special cases of the procedure are considered, including E-MS with the generalized information criteria (GIC), and E-MS with the adaptive fence (AF; Jiang et al. 2008). We prove numerical convergence of the E-MS algorithm as well as consistency in model selection of the limiting model of the E-MS convergence, for E-MS with GIC and E-MS with AF. We study the impact on model selection of different missing data mechanisms. Furthermore, we carry out extensive simulation studies on the finite-sample performance of the E-MS with comparisons to other procedures. The methodology is also illustrated on a real data analysis involving QTL mapping for an agricultural study on barley grains.

  14. The E-MS Algorithm: Model Selection with Incomplete Data

    PubMed Central

    Jiang, Jiming; Nguyen, Thuan; Rao, J. Sunil

    2014-01-01

    We propose a procedure associated with the idea of the E-M algorithm for model selection in the presence of missing data. The idea extends the concept of parameters to include both the model and the parameters under the model, and thus allows the model to be part of the E-M iterations. We develop the procedure, known as the E-MS algorithm, under the assumption that the class of candidate models is finite. Some special cases of the procedure are considered, including E-MS with the generalized information criteria (GIC), and E-MS with the adaptive fence (AF; Jiang et al. 2008). We prove numerical convergence of the E-MS algorithm as well as consistency in model selection of the limiting model of the E-MS convergence, for E-MS with GIC and E-MS with AF. We study the impact on model selection of different missing data mechanisms. Furthermore, we carry out extensive simulation studies on the finite-sample performance of the E-MS with comparisons to other procedures. The methodology is also illustrated on a real data analysis involving QTL mapping for an agricultural study on barley grains. PMID:26783375

  15. Applying Recursive EM to Scene Segmentation

    NASA Astrophysics Data System (ADS)

    Bachmann, Alexander

    In this paper a novel approach for the interdependent task of multiple object tracking and scene segmentation is presented. The method partitions a stereo image sequence of a dynamic 3-dimensional (3D) scene into its most prominent moving groups with similar 3D motion. The unknown set of motion parameters is recursively estimated using an iterated extended Kalman filter (IEKF) which will be derived from the expectation-maximization (EM) algorithm. The EM formulation is used to incorporate a probabilistic data association measure into the tracking process. In a subsequent segregation step, each image point is assigned to the object hypothesis with maximum a posteriori (MAP) probability. Within the association process, which is implemented as labeling problem, a Markov Random Field (MRF) is used to express our expectations on spatial continuity of objects.

  16. Intense EM filamentation in relativistic hot plasmas

    NASA Astrophysics Data System (ADS)

    Hu, Qiang-Lin; Chen, Zhong-Ping; Mahajan, Swadesh M.

    2017-03-01

    Through 2D particle-in-cell (PIC) simulations, we demonstrate that the nature of filamentation of a high intensity electromagnetic (EM) pulse propagating in an underdense plasma, is profoundly affected at relativistically high temperatures. The "relativistic" filaments are sharper, are dramatically extended (along the direction of propagation), and live much longer than their lower temperature counterparts. The thermally boosted electron inertia is invoked to understand this very interesting and powerful phenomenon.

  17. Cryo-EM: Spinning the Micelles Away.

    PubMed

    Singh, Satinder K; Sigworth, Fred J

    2015-09-01

    Structural characterization of integral membrane proteins (MPs) demands that the samples be pure, monodisperse, and stable. Detergents are required to extract MPs from the lipid bilayer in which they reside and to stabilize them for downstream biophysical analyses. Some of the best MP-stabilizing detergents pose problems for cryo-EM studies, but in this issue of Structure, Hauer et al. (2015) now offer a solution called GraDeR.

  18. Leukocyte Recognition Using EM-Algorithm

    NASA Astrophysics Data System (ADS)

    Colunga, Mario Chirinos; Siordia, Oscar Sánchez; Maybank, Stephen J.

    This document describes a method for classifying images of blood cells. Three different classes of cells are used: Band Neutrophils, Eosinophils and Lymphocytes. The image pattern is projected down to a lower dimensional sub space using PCA; the probability density function for each class is modeled with a Gaussian mixture using the EM-Algorithm. A new cell image is classified using the maximum a posteriori decision rule.

  19. TandEM: Titan and Enceladus mission

    NASA Astrophysics Data System (ADS)

    Coustenis, A.; Atreya, S. K.; Balint, T.; Brown, R. H.; Dougherty, M. K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R. A.; Griffith, C. A.; Gurvits, L. I.; Jaumann, R.; Langevin, Y.; Leese, M. R.; Lunine, J. I.; McKay, C. P.; Moussas, X.; Müller-Wodarg, I.; Neubauer, F.; Owen, T. C.; Raulin, F.; Sittler, E. C.; Sohl, F.; Sotin, C.; Tobie, G.; Tokano, T.; Turtle, E. P.; Wahlund, J.-E.; Waite, J. H.; Baines, K. H.; Blamont, J.; Coates, A. J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R. D.; Morse, A.; Porco, C. C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J. C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D. H.; Bénilan, Y.; Bertucci, C.; Bézard, B.; Bjoraker, G. L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M. T.; Chassefière, E.; Coll, P.; Combes, M.; Cooper, J. F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I. A.; de Angelis, E.; de Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F. M.; Fortes, A. D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Küppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le Mouélic, S.; Lebonnois, S.; Ledvina, S.; Li, J.; Livengood, T. A.; Lopes, R. M.; Lopez-Moreno, J.-J.; Luz, D.; Mahaffy, P. R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Menor Salvan, C.; Milillo, A.; Mitchell, D. G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, C. D.; Nixon, C. A.; Nna Mvondo, D.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F. T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Ruiz Bermejo, M.; Sarris, E. T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L. J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D. F.; Szego, K.; Szopa, C.; Thissen, R.; Tomasko, M. G.; Toublanc, D.; Vali, H.; Vardavas, I.; Vuitton, V.; West, R. A.; Yelle, R.; Young, E. F.

    2009-03-01

    TandEM was proposed as an L-class (large) mission in response to ESA’s Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfière) and possibly several landing probes to be delivered through the atmosphere.

  20. TandEM: Titan and Enceladus mission

    USGS Publications Warehouse

    Coustenis, A.; Atreya, S.K.; Balint, T.; Brown, R.H.; Dougherty, M.K.; Ferri, F.; Fulchignoni, M.; Gautier, D.; Gowen, R.A.; Griffith, C.A.; Gurvits, L.I.; Jaumann, R.; Langevin, Y.; Leese, M.R.; Lunine, J.I.; McKay, C.P.; Moussas, X.; Muller-Wodarg, I.; Neubauer, F.; Owen, T.C.; Raulin, F.; Sittler, E.C.; Sohl, F.; Sotin, Christophe; Tobie, G.; Tokano, T.; Turtle, E.P.; Wahlund, J.-E.; Waite, J.H.; Baines, K.H.; Blamont, J.; Coates, A.J.; Dandouras, I.; Krimigis, T.; Lellouch, E.; Lorenz, R.D.; Morse, A.; Porco, C.C.; Hirtzig, M.; Saur, J.; Spilker, T.; Zarnecki, J.C.; Choi, E.; Achilleos, N.; Amils, R.; Annan, P.; Atkinson, D.H.; Benilan, Y.; Bertucci, C.; Bezard, B.; Bjoraker, G.L.; Blanc, M.; Boireau, L.; Bouman, J.; Cabane, M.; Capria, M.T.; Chassefiere, E.; Coll, P.; Combes, M.; Cooper, J.F.; Coradini, A.; Crary, F.; Cravens, T.; Daglis, I.A.; de Angelis, E.; De Bergh, C.; de Pater, I.; Dunford, C.; Durry, G.; Dutuit, O.; Fairbrother, D.; Flasar, F.M.; Fortes, A.D.; Frampton, R.; Fujimoto, M.; Galand, M.; Grasset, O.; Grott, M.; Haltigin, T.; Herique, A.; Hersant, F.; Hussmann, H.; Ip, W.; Johnson, R.; Kallio, E.; Kempf, S.; Knapmeyer, M.; Kofman, W.; Koop, R.; Kostiuk, T.; Krupp, N.; Kuppers, M.; Lammer, H.; Lara, L.-M.; Lavvas, P.; Le, Mouelic S.; Lebonnois, S.; Ledvina, S.; Li, Ji; Livengood, T.A.; Lopes, R.M.; Lopez-Moreno, J. -J.; Luz, D.; Mahaffy, P.R.; Mall, U.; Martinez-Frias, J.; Marty, B.; McCord, T.; Salvan, C.M.; Milillo, A.; Mitchell, D.G.; Modolo, R.; Mousis, O.; Nakamura, M.; Neish, Catherine D.; Nixon, C.A.; Mvondo, D.N.; Orton, G.; Paetzold, M.; Pitman, J.; Pogrebenko, S.; Pollard, W.; Prieto-Ballesteros, O.; Rannou, P.; Reh, K.; Richter, L.; Robb, F.T.; Rodrigo, R.; Rodriguez, S.; Romani, P.; Bermejo, M.R.; Sarris, E.T.; Schenk, P.; Schmitt, B.; Schmitz, N.; Schulze-Makuch, D.; Schwingenschuh, K.; Selig, A.; Sicardy, B.; Soderblom, L.; Spilker, L.J.; Stam, D.; Steele, A.; Stephan, K.; Strobel, D.F.; Szego, K.; Szopa,

    2009-01-01

    TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (Montgolfi??re) and possibly several landing probes to be delivered through the atmosphere. ?? Springer Science + Business Media B.V. 2008.

  1. The US DOE EM international program

    SciTech Connect

    Elmetti, Rosa R.; Han, Ana M.; Roach, Jay A.

    2013-07-01

    The U.S. Department of Energy (DOE) Office of Environmental Management (EM) conducts international collaboration activities in support of U.S. policies and objectives regarding the accelerated risk reduction and remediation of environmental legacy of the nations' nuclear weapons program and government sponsored nuclear energy research. The EM International Program supported out of the EM Office of the Associate Principal Deputy Assistant Secretary pursues collaborations with foreign government organizations, educational institutions and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. In fiscal year (FY) 2012, the International Program awarded eight international collaborative projects for work scope spanning waste processing, groundwater and soil remediation, deactivation and decommissioning (D and D) and nuclear materials disposition initiatives to seven foreign organizations. Additionally, the International Program's scope and collaboration opportunities were expanded to include technical as well as non-technical areas. This paper will present an overview of the on-going tasks awarded in FY 2012 and an update of upcoming international activities and opportunities for expansion into the remainder of FY 2013 and beyond. (authors)

  2. Guidance for establishment and implementation of a national sample management program in support of EM environmental sampling and analysis activities

    SciTech Connect

    Not Available

    1994-02-18

    The role of the National Sample Management Program (NSMP) proposed by the Department of Energy`s Office of Environmental Management (EM) is to be a resource for EM programs and for local Field Sample Management Programs (FSMPs). It will be a source of information on sample analysis and data collection within the DOE complex. Therefore the NSMP`s primary role is to coordinate and function as a central repository for information collected from the FSMPs. An additional role of the NSMP is to monitor trends in data collected from the FSMPs over time and across sites and laboratories. Tracking these trends will allow identification of potential problems in the sampling and analysis process.

  3. Nuclear weapons effects studies for the 5ESS (trademark) switch. Volume 2. EM (electromagnetic) shielding characteristics of structures. Final report, 1 July 1985-30 September 1986

    SciTech Connect

    Beauchamp, N.A.; Farber, L.; Federico, S.S.

    1986-09-01

    As part of its Electromagnetic Pulse (EMP) Mitigation Program, the National Communications System (NCS) funded ATandT to study the ability of the ATandT 5ESS(TM) Switch to withstand the potentially disabling effects of EMP from high-altitude nuclear bursts and fallout radiation from distant near-surface bursts. This volume documents the study to characterize the electromagnetic (EM) shielding effectiveness of the trailer used to shelter the test switch during simulated-EMP testing and of central-office buildings in which 5ESS Switches might be housed in the Public Switched Network. The results were used to estimate the attenuated fields incident upon n installed switch and its associated intra-office cabling. Because the building types examined can provide a wide range of EM shielding values, no single set of attenuation curves will suffice to characterize central-office structures.

  4. The deglaciation of Central Scandinavia

    NASA Astrophysics Data System (ADS)

    Faulkner, T. L.

    2009-12-01

    'Central Scandinavia' extends from the Norwegian coast across the Helgeland Nappe Complex to the Caledonide thrust front in Sweden (Faulkner, 2005, who studied the effects of Weichselian deglaciation on the speleogenesis of ~1000 local Caledonide marble caves). Deglaciation was driven by two summer heat fluxes: warming by the sea as it encroached up fjords and caused the icesheet margin to retreat eastwards (accompanied by deglacial seismicity) and direct solar warming that caused the icesheet to ablate from its upper surface (Grønlie, 1975; Mörner, 1979; Andersen and Karlsen, 1986; Sørensen et al., 1987; Mangerud, 1991; Bergstrøm, 1995). The melting height followed an empirical parabolic time relationship (H=0.75t2: Grønlie, 1975), based on many geomorphological observations. Faulkner (2005) reconstructed the Grønlie formula using information about the Younger Dryas (YD) isostatic uplift that increased inland as: H=1700+5(YD isobase-220)-0.75x10-4x(13500-t)2 m, where t=14Ca BP. Deglaciation was modelled by drawing deglacial maps at c. 300a intervals that show the advance of the sea, the recession of the icesheet margin, the synchronous thinning of the icesheet, and the evolution of ice-dammed lakes (IDLs), after the ice began to melt vigorously in the Bølling interstadial below the present 1700m altitude (at the 220m YD isobase at Børgefjell) that was already ice-free. After c. 11ka BP, the melting height lowered at roughly 0.5ma-1 at all isobases. The formula agrees with many marine dates to within 300a in the central and northern part of the area, but downwasting by calving was much faster along the coast, as the sea submerged large areas of the isostatically-depressed strandflat. Across the Swedish border, there is evidence that large IDLs and glaciers remained longer than predicted. Most of the area was systematically flooded by glacial meltwater for periods of 800-120014Ca during deglaciation as local IDLs lowered and coalesced (commonly at j

  5. Geology of offshore central California

    SciTech Connect

    McCulloch, D.S.; Lewis, S.D.

    1988-03-01

    The offshore central California margin records Mesozoic and Cenozoic events attributable to continental and oceanic plate interactions. Terranes, some carried thousands of kilometers northward on the Kula and/or Farallon plates, were accreted to North America by late Eocene. Following accretion to North America, terranes along the margin were silvered and redistributed by strike-slip motion along the San Andreas and related faults. During Oligocene global low sea level, much of the coastal margin was subareal and erosion stripped Upper Cretaceous and Eocene strata from elevated basement blocks. These basement blocks subsequently subsided along large-displacement near-coastal faults, and shallow-water marine upper Oligocene and/or lower Miocene volcanics on the present shelf were covered by hemipelagic sediment at bathyal to mid-bathyal depths. This subsidence coincided with tectonism and significant changes in water depth elsewhere around the Pacific margin, and may have been related to a change in Pacific and North American plate relative motion that produced transtensional motion along the California margin. Transtension may have initiated both rupture and volcanism along the San Andreas fault system at about 23 Ma and wrench tectonic deformation on the shelf. During the late Miocene, growing structural highs on the shelf edge formed elongate shelf basins. A compressional component in Pacific and North America plate relative motion, which began between 5 and 3 Ma, produced strike-parallel folds and compressional faults that now dominate the structural grain of the offshore basins. Continued compressive deformation along coastal California is documented by active thrust faults, rapid coastal uplift, and earthquake focal mechanism solutions indicative of northeast-southwest compression.

  6. Historical Seismicity of Central Panama

    NASA Astrophysics Data System (ADS)

    Camacho, E.

    2013-05-01

    Central Panama lies in the Panama microplate, neighboring seismically active regions of Costa Rica and Colombia. This region, crossed by the Panama Canal, concentrates most of the population and economic activity of the Republic of Panama. Instrumental observation of earthquakes in Panama began on 1882 by the Compagnie Universelle du Canal Interocéanique de Panama and continued from 1904 to 1977 by the Panama Canal Company. From October 1997 to March 1998 the USGS deployed a temporary digital seismic network. Since 2003 this region is monitored by a digital seismic network operated by the Panama Canal Authority and I complemented by the broad band stations of the University of Panama seismic network. The seismicity in this region is very diffuse and the few events which are recorded have magnitudes less than 3.0. Historical archives and antique newspapers from Spain, Colombia, Panama and the United Sates have been searched looking for historical earthquake information which could provide a better estimate of the seismicity in this region. We find that Panama City has been shaken by two destructive earthquakes in historical times. One by a local fault (i.e. Pedro Miguel fault) on May 2, 1621 (I=Vlll MM), and a subduction event from the North Panama Deformed Belt (NPDB) on September 7, 1882 (I=Vll MM). To test these findings two earthquakes scenarios were generated, using SELENA, for Panama City Old Quarter. Panama City was rebuilt on January 21, 1673, on a rocky point facing the Pacific Ocean after the sack by pirate Morgan on January 28, 1671. The pattern of damage to calicanto (unreinforced colonial masonry) and wood structures for a crustal local event are higher than those for an event from the NPDB and seem to confirm that the city has not been shaken by a major local event since May 2, 1621 and a subduction event since September 7, 1882

  7. Centralized consolidation/recycling center

    SciTech Connect

    St. Georges, L.T.; Poor, A.D.

    1995-05-01

    There are approximately 175 separate locations on the Hanford Site where dangerous waste is accumulated in hundreds of containers according to compatibility. Materials that are designated as waste could be kept from entering the waste stream by establishing collection points for these materials and wastes and then transporting them to a centralized consolidation/recycling center (hereinafter referred to as the consolidation center). Once there the materials would be prepared for offsite recycling. This document discusses the removal of batteries, partially full aerosol cans, and DOP light ballasts from the traditional waste management approach, which eliminates 89 satellite accumulation areas from the Hanford Site (43 for batteries, 33 for aerosols, and 13 for DOP ballasts). Eliminating these 89 satellite accumulation areas would reduce by hundreds the total number of containers shipped offsite as hazardous waste (due to the increase in containers when the wastes that are accumulated are segregated according to compatibility for final shipment). This new approach is in line with the U.S. Environmental Protection Agency`s (EPA) draft Universal Waste Rules for these {open_quotes}nuisance{close_quotes} and common waste streams. Additionally, future reviews of other types of wastes that can be handled in this less restrictive and more cost-effective manner will occur as part of daily operations at the consolidation center. The Hanford Site has been identified as a laboratory for reinventing government by the Secretary of the U.S. Department of Energy (DOE), Hazel O`Leary, and as a demonstration zone where {open_quotes}innovative ideas, processes and technologies can be created, tested and demonstrated.{close_quotes} Additionally, DOE, EPA, and the Washington State Department of Ecology (Ecology) have agreed to cut Hanford cleanup costs by $1 billion over a 5-year period.

  8. Tethyan evolution of central Asia

    SciTech Connect

    Sengor, A.M.C. )

    1990-05-01

    The study area extends from the eastern shores of the Caspian Sea in the west to the Helan Shan and Longmen Shan in the east and from about 40{degree}N parallel in the north to the neo-Tethyan sutures in the south, thus including what is called Middle Asia in the Soviet literature. In the region thus delineated lies the boundary between the largely late Paleozoic core of Asia (Altaids) and the Tethyside superorogenic complex. This boundary passes through continental objects that collided with nuclear Asia in the late Paleozoic to terminate its Altaid evolution. Subduction to the south of some of these had commenced before they collided (e.g., Tarim in the Kuen-Lun), in others later (e.g., South Ghissar area west of Pamirs). This subduction 1ed, in the late Paleozoic, to the opening of marginal basins, at least one of which may be partly extant (Tarim). Giant subduction accretion complexes of Paleozoic to earliest Triassic age dominate farther south in the basement of Turan (mainly in Turkmenian SSR) and in the Kuen-Lun/Nan Shan ranges. No discrete continental collisions or any continental basement in these regions could be unequivocally recognized contrary to most current interpretations. Magmatic arcs that developed along the southern margin of Asia in the late Paleozoic to early Mesozoic grew atop these subduction-accretion complexes and record a gradual southerly migration of magmatism through time. Subduction also dominated the northern margin of Gondwanaland between Iran and China in late Paleozoic time, although the record in Afghanistan and northwest Tibet is scrappy. It led to back-arc basin formation, which in Iran and Oman became neo-Tethys and, in at least parts of central Asia, the Waser-Mushan-Pshart/Banggong Co-Nu Jiang ocean. This ocean was probably connected with the Omani part of the neo-Tethys via the Sistan region.

  9. 12 CFR 234.4 - Standards for central securities depositories and central counterparties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... disclosed, and permit fair and open access. (3) The central securities depository or central counterparty holds assets in a manner whereby risk of loss or of delay in its access to them is minimized. Assets...

  10. 12 CFR 234.4 - Standards for central securities depositories and central counterparties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... disclosed, and permit fair and open access. (3) The central securities depository or central counterparty holds assets in a manner whereby risk of loss or of delay in its access to them is minimized. Assets...

  11. The Latino Experience in Central Falls

    ERIC Educational Resources Information Center

    Holland, William R.

    2011-01-01

    Central Falls is, by far, the poorest community in Rhode Island. More than 40 percent of the children under 18 live in poverty, and 40 percent of that group live in severe poverty. At Central Falls High School, low-income Latino students have fallen behind their white counterparts, with shockingly low graduation, poor literacy, and low…

  12. Traveling Policies: Hijacked in Central Asia

    ERIC Educational Resources Information Center

    Silova, Iveta

    2005-01-01

    Since the collapse of the Soviet Union, Central Asian education reform discourses have become increasingly similar to distinctive Western policy discourses traveling globally across national boundaries. Tracing the trajectory of "traveling policies" in Central Asia, this article discusses the way Western education discourses have been…

  13. 32 CFR 154.41 - Central adjudication.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PERSONNEL SECURITY PROGRAM REGULATION Adjudication § 154.41 Central adjudication. (a) To ensure uniform... Defense Agencies shall establish a single Central Adjudication Facility for his/her component. The... to act on behalf of the head of the Component concerned with respect to personnel...

  14. 32 CFR 154.41 - Central adjudication.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PERSONNEL SECURITY PROGRAM REGULATION Adjudication § 154.41 Central adjudication. (a) To ensure uniform... Defense Agencies shall establish a single Central Adjudication Facility for his/her component. The... to act on behalf of the head of the Component concerned with respect to personnel...

  15. External Review Teams Training in Central America

    ERIC Educational Resources Information Center

    Silva-Trivino, Moises; Ramirez-Gatica, Soledad

    2004-01-01

    Many Latin American countries have started actions to promote a higher education quality assurance system. Central America appears as a regional effort that includes universities from all seven countries under the initiative of Central American University Higher Council (CSUCA). After focusing in quality management and self-study processes, CSUCA…

  16. Connecting Students, Creating Futures at Central Campus

    ERIC Educational Resources Information Center

    Rosin, Julie; Erbes, Elizabeth; Britt, James; Good, Bill

    2012-01-01

    Des Moines is an urban community located in the heart of Iowa. Des Moines Public Schools serves 32,000 students in a system with 62 buildings, including Central Campus--a Regional Academy. Central Campus is housed in four buildings, including the main campus at 1800 Grand located on the western edge of downtown Des Moines. As a regional academy,…

  17. Investigation of differential evolution using temporal centralities

    NASA Astrophysics Data System (ADS)

    Tomaszek, Lukas; Zelinka, Ivan

    2017-07-01

    In this article we are continuing in our research to show mutual intersection of two different areas of research: complex network and evolutionary computation. In this article we briefly describe cost functions and temporal centralities, than we show how to convert differential evolution into complex network and show plots for temporal centralities for two selected functions.

  18. Raising the Bar in Central America

    ERIC Educational Resources Information Center

    Campbell, Monica

    2007-01-01

    Several years ago, students in Central America rarely leave their countries to find work elsewhere. Such is the case of Sebastian Pinto who felt that his degree would not mean much beyond Guatemala, his country. But now, universities in Central American have started to offer regionally accredited degrees that would allow students' credentials to…

  19. Tree biomass in the North Central Region.

    Treesearch

    Gerhard K. Raile; Pamela J. Jakes

    1982-01-01

    Methods for calculating tree biomass are outlined, and the biomass on commercial forest land is estimated for 11 north-central states. Tree biomass in the North Central Region totals 3.6 billion tons, or 50 tons per commercial forest acre. For all species, total tree biomass is concentrated in growing-stock boles.

  20. Comment on ``Subgraph centrality in complex networks''

    NASA Astrophysics Data System (ADS)

    Stevanović, Dragan

    2013-08-01

    We disprove a conjecture of Estrada and Rodríguez-Velázquez [Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.71.056103 71, 056103 (2005)] that if a graph has identical subgraph centrality for all nodes, then the closeness and betweenness centralities are also identical for all nodes.

  1. Visualizing the Central Limit Theorem through Simulation

    ERIC Educational Resources Information Center

    Ruggieri, Eric

    2016-01-01

    The Central Limit Theorem is one of the most important concepts taught in an introductory statistics course, however, it may be the least understood by students. Sure, students can plug numbers into a formula and solve problems, but conceptually, do they really understand what the Central Limit Theorem is saying? This paper describes a simulation…

  2. External Review Teams Training in Central America

    ERIC Educational Resources Information Center

    Silva-Trivino; Moises; Ramirez-Gatica, Soledad

    2004-01-01

    Many Latin American countries have started actions to promote a higher education quality assurance system. Central America appears as a regional effort that includes universities from all seven countries under the initiative of Central American University Higher Council (CSUCA). After focusing in quality management and self-study processes, CSUCA…

  3. Lymphatic Leak Complicating Central Venous Catheter Insertion

    SciTech Connect

    Barnacle, Alex M. Kleidon, Tricia M.

    2005-12-15

    Many of the risks associated with central venous access are well recognized. We report a case of inadvertent lymphatic disruption during the insertion of a tunneled central venous catheter in a patient with raised left and right atrial pressures and severe pulmonary hypertension, which led to significant hemodynamic instability. To our knowledge, this rare complication is previously unreported.

  4. Voices from the Field: Central Office Administrators

    ERIC Educational Resources Information Center

    Dickson, Ken

    2015-01-01

    School systems' central office administrators sometimes take paths that seem easiest, even when it is clear the paths will not lead to sustained positive results that are needed--particularly in terms of twice-exceptional (2e) students. To appropriately address the needs of 2e learners, we must ensure that central office administrative services…

  5. Centralized scheduling an unanticipated revenue cycle opportunity.

    PubMed

    O'Neill, Daniel P; Kenniff, Peter B

    2007-09-01

    Centralized outpatient scheduling can provide acute care hospitals with accessibility and service levels equal to freestanding facilities, enabling hospitals to recapture lost market share. Two implementation strategies are critical to the success of centralized scheduling: Correctly developing the schedule. Managing the incoming call volume.

  6. South Central California Coastline and Channel Islands

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This distant and very oblique image of the south Central California Coastline and Channel Islands (35.0N, 119.0W) offers a spectacular and scenic view of the southern west coast, the central San Joaquin Valley, the entire Sierra Nevada Range and across the southwest to the Rocky Mountains on the horizon.

  7. Forest statistics of central and northern Indiana

    Treesearch

    The Forest Survey Organization. Central States Forest Experiment Station

    1952-01-01

    The Forest Survey is conducted in the various regions by the forest experiment stations of the Forest Service. In Indiana the project is directed by the Central States Forest Experiment Station with headquarters in Columbus, Ohio. This Survey Release presents the more significant preliminary statistics on the forest area and timber volume for Central and Northern...

  8. The Role Centrality on Story Category Saliency.

    ERIC Educational Resources Information Center

    Omanson, Richard C.

    Four experiments involving 54 adults were performed to examine the relationship between the effects of story grammar categories and content centrality on subjects' importance ratings, summaries, immediate recall, and delayed recall. Results of the studies indicated that central content units were judged as more important and were better recalled…

  9. Central Falls' Kids First: A Case Study.

    ERIC Educational Resources Information Center

    Tufts Univ., Medford, MA. Center on Hunger, Poverty and Nutrition Policy.

    Central Falls' Kids First, a 3-year initiative was designed to eradicate local childhood hunger through the expansion of federal child nutrition programs in Central Falls, a small, densely populated, ethnically diverse and low-income city in northeastern Rhode Island. A strong community partnership was created and included the office of the city's…

  10. Raising the Bar in Central America

    ERIC Educational Resources Information Center

    Campbell, Monica

    2007-01-01

    Several years ago, students in Central America rarely leave their countries to find work elsewhere. Such is the case of Sebastian Pinto who felt that his degree would not mean much beyond Guatemala, his country. But now, universities in Central American have started to offer regionally accredited degrees that would allow students' credentials to…

  11. Voices from the Field: Central Office Administrators

    ERIC Educational Resources Information Center

    Dickson, Ken

    2015-01-01

    School systems' central office administrators sometimes take paths that seem easiest, even when it is clear the paths will not lead to sustained positive results that are needed--particularly in terms of twice-exceptional (2e) students. To appropriately address the needs of 2e learners, we must ensure that central office administrative services…

  12. Central State University: Phase II Report

    ERIC Educational Resources Information Center

    Ohio Board of Regents, 2012

    2012-01-01

    In accordance with Ohio Amended Substitute House Bill 153, the Chancellor submitted to the state Legislature and the Governor a plan, developed in consultation with Central State University, that assures the Central State Supplement will be used to promote the goals of increasing enrollment, improving course completion, and increasing the number…

  13. Proceedings, 8th Central Hardwood Forest Conference

    Treesearch

    Larry H. McCormick; Kurt W., eds. Gottschalk

    1991-01-01

    Two invited papers, forty-five volunteer papers, and twenty volunteer poster summaries presented at the 8th Central Hardwood Forest Conference. Presentations were on economics, forest amenities, harvesting, utilization, physiology, genetics, ecology, regeneration, silviculture, protection, management, hydrology, soils, nutrient cycling, and hardwood markets of central...

  14. Visualizing the Central Limit Theorem through Simulation

    ERIC Educational Resources Information Center

    Ruggieri, Eric

    2016-01-01

    The Central Limit Theorem is one of the most important concepts taught in an introductory statistics course, however, it may be the least understood by students. Sure, students can plug numbers into a formula and solve problems, but conceptually, do they really understand what the Central Limit Theorem is saying? This paper describes a simulation…

  15. Centralization and Decentralization in American Education Policy

    ERIC Educational Resources Information Center

    DeBoer, Jennifer

    2012-01-01

    This article examines the trend toward centralization in American education policy over the last century through a variety of lenses. The overall picture that emerges is one of a continuous tug-of-war, with national and local policymakers stumbling together toward incrementally more standardized and centralized policies. There is a center of power…

  16. Central Falls' Kids First: A Case Study.

    ERIC Educational Resources Information Center

    Tufts Univ., Medford, MA. Center on Hunger, Poverty and Nutrition Policy.

    Central Falls' Kids First, a 3-year initiative was designed to eradicate local childhood hunger through the expansion of federal child nutrition programs in Central Falls, a small, densely populated, ethnically diverse and low-income city in northeastern Rhode Island. A strong community partnership was created and included the office of the city's…

  17. Traveling Policies: Hijacked in Central Asia

    ERIC Educational Resources Information Center

    Silova, Iveta

    2005-01-01

    Since the collapse of the Soviet Union, Central Asian education reform discourses have become increasingly similar to distinctive Western policy discourses traveling globally across national boundaries. Tracing the trajectory of "traveling policies" in Central Asia, this article discusses the way Western education discourses have been…

  18. South-central Alaska forests: inventory highlights.

    Treesearch

    Sally Campbell; Willem W.S. van Hees; Bert. Mead

    2005-01-01

    This publication presents highlights of a recent south-central Alaska inventory conducted by the Pacific Northwest Research Station Forest Inventory and Analysis Program (USDA Forest Service). South-central Alaska has about 18.5 million acres, of which one-fifth (4 million acres) is forested. Species diversity is greatest in closed and open Sitka spruce forests, spruce...

  19. Central Life Interests and Job Satisfaction.

    ERIC Educational Resources Information Center

    Dubin, Robert; And Others

    Data on central life interests (CLI) and five aspects of job satisfaction were obtained in a sample of bluecollar males and two samples of clerical females. Both a multiple discriminant analysis and a bivariate analysis were performed. The results of these analyses showed that central life interest was significantly related to the total set of job…

  20. Novel central nervous system drug delivery systems.

    PubMed

    Stockwell, Jocelyn; Abdi, Nabiha; Lu, Xiaofan; Maheshwari, Oshin; Taghibiglou, Changiz

    2014-05-01

    For decades, biomedical and pharmaceutical researchers have worked to devise new and more effective therapeutics to treat diseases affecting the central nervous system. The blood-brain barrier effectively protects the brain, but poses a profound challenge to drug delivery across this barrier. Many traditional drugs cannot cross the blood-brain barrier in appreciable concentrations, with less than 1% of most drugs reaching the central nervous system, leading to a lack of available treatments for many central nervous system diseases, such as stroke, neurodegenerative disorders, and brain tumors. Due to the ineffective nature of most treatments for central nervous system disorders, the development of novel drug delivery systems is an area of great interest and active research. Multiple novel strategies show promise for effective central nervous system drug delivery, giving potential for more effective and safer therapies in the future. This review outlines several novel drug delivery techniques, including intranasal drug delivery, nanoparticles, drug modifications, convection-enhanced infusion, and ultrasound-mediated drug delivery. It also assesses possible clinical applications, limitations, and examples of current clinical and preclinical research for each of these drug delivery approaches. Improved central nervous system drug delivery is extremely important and will allow for improved treatment of central nervous system diseases, causing improved therapies for those who are affected by central nervous system diseases.

  1. Connecting Students, Creating Futures at Central Campus

    ERIC Educational Resources Information Center

    Rosin, Julie; Erbes, Elizabeth; Britt, James; Good, Bill

    2012-01-01

    Des Moines is an urban community located in the heart of Iowa. Des Moines Public Schools serves 32,000 students in a system with 62 buildings, including Central Campus--a Regional Academy. Central Campus is housed in four buildings, including the main campus at 1800 Grand located on the western edge of downtown Des Moines. As a regional academy,…

  2. Historic America: The South Central States.

    ERIC Educational Resources Information Center

    Beardsley, Donna A.

    Many sites in the south central states recall the procession of people who came across the continent with the passing frontier. This paper elaborates on several historic sites in the south central United States. The purpose of the paper is to introduce a series of places to the students and teachers of U.S. history. The paper recommends that…

  3. Central station market development strategies for photovoltaics

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Federal market development strategies designed to accelerate the market penetration of central station applications of photovoltaic energy system are analyzed. Since no specific goals were set for the commercialization of central station applications, strategic principles are explored which, when coupled with specific objectives for central stations, can produce a market development implementation plan. The study includes (1) background information on the National Photovoltaic Program, photovoltaic technology, and central stations; (2) a brief market assessment; (3) a discussion of the viewpoints of the electric utility industry with respect to solar energy; (4) a discussion of commercialization issues; and (5) strategy principles. It is recommended that a set of specific goals and objectives be defined for the photovoltaic central station program, and that these goals and objectives evolve into an implementation plan that identifies the appropriate federal role.

  4. Central registry in psychiatry: A structured review

    PubMed Central

    Prakash, Jyoti; Ramakrishnan, TS; Das, R. C.; Srivastava, K.; Mehta, Suresh; Shashikumar, R.

    2014-01-01

    Background: Central registry in psychiatry is being practiced in few countries and has been found useful in research and clinical management. Role of central registry has also expanded over the years. Materials and Methods: All accessible internet database Medline, Scopus, Embase were accessed from 1990 till date. Available data were systematically reviewed in structured manner and analyzed. Results: Central registry was found useful in epidemiological analysis, association studies, outcome studies, comorbidity studies, forensic issue, effective of medication, qualitative analysis etc., Conclusion: Central registry proves to be effective tool in quantitative and qualitative understanding of psychiatry practice. Findings of studies from central registry can be useful in modifying best practice and evidence based treatment in psychiatry. PMID:25535438

  5. AAPT Diagnostic Criteria for Central Neuropathic Pain.

    PubMed

    Widerström-Noga, Eva; Loeser, John D; Jensen, Troels Staehelin; Finnerup, Nanna Brix

    2017-06-27

    Central neuropathic pain, which is pain caused by a lesion or disease of the central somatosensory nervous system, is a serious consequence of spinal cord injury, stroke, multiple sclerosis, and other conditions affecting the central nervous system. A collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership and the American Pain Society, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks-American Pain Society Pain Taxonomy (AAPT) initiative, invited a working group to develop diagnostic criteria for central neuropathic pain. The criteria for central neuropathic pain that were developed expand upon existing criteria for neuropathic pain and the International Classification of Diseases 11th Revision draft criteria to ensure consistency. This article focuses on central neuropathic pain associated with spinal cord injury, stroke, and multiple sclerosis, but the AAPT framework can be extended to central pain due to other causes such as traumatic brain injury. The classification of central neuropathic pain is organized according to the AAPT multidimensional framework, specifically: 1) core diagnostic criteria, 2) common features, 3) common medical and psychiatric comorbidities, 4) neurobiological, psychosocial, and functional consequences, and 5) putative neurobiological and psychosocial mechanisms, risk factors, and protective factors. The AAPT chronic central neuropathic pain taxonomy provides a classification for central pain associated with spinal cord injury, stroke, and multiple sclerosis. The diagnostic criteria are organized according to the AAPT multidimensional framework, specifically: 1) core diagnostic criteria, 2) common features, 3) common medical and psychiatric comorbidities, 4) neurobiological, psychosocial, and functional consequences, and 5) putative neurobiological and psychosocial

  6. 2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. HI PAR (ACQUISITION RADAR) TOWER AND ENLISTED MEN (EM) BARRACKS WITH RADAR ATTACHED. - Nike Hercules Missile Battery Summit Site, Battery Control Administration & Barracks Building, Anchorage, Anchorage, AK

  7. The State of Emergency Medical Services (EMS) Systems in Africa.

    PubMed

    Mould-Millman, Nee-Kofi; Dixon, Julia M; Sefa, Nana; Yancey, Arthur; Hollong, Bonaventure G; Hagahmed, Mohamed; Ginde, Adit A; Wallis, Lee A

    2017-02-23

    Introduction Little is known about the existence, distribution, and characteristics of Emergency Medical Services (EMS) systems in Africa, or the corresponding epidemiology of prehospital illness and injury.

  8. Recruitment and retention in rural and urban EMS: results from a national survey of local EMS directors.

    PubMed

    Freeman, Victoria A; Slifkin, Rebecca T; Patterson, P Daniel

    2009-01-01

    Maintaining an adequate staff is a challenge for rural emergency medical services (EMS) providers. This national survey of local EMS directors finds that rural EMS are more likely to be freestanding, that is, not affiliated with other public services, to employ only emergency medical technician-basics (EMT-Bs), and to be all volunteer. Rural EMS directors are more likely than urban ones to report that they are not currently fully staffed. The most common barriers to recruitment of EMTs in both urban and rural areas include unwillingness of community members to volunteer and lack of certified EMTs in the area. In rural areas, barriers to EMT training were noted more often than in urban areas as was the lack of employer support for employee volunteers. Similar rural training barriers affected retention of staff. Rural respondents reported that they lose staff to burnout and to difficulty in meeting continuing education requirements. Among rural respondents, those who direct all-volunteer EMS were the most likely to report recruitment and retention problems. The results suggest areas for further study including how volunteer EMS agencies can transition to paid agencies, how to bring EMS education to rural areas, and how EMS can work with other agencies to ensure EMS viability.

  9. Central hypothyroidism - a neglected thyroid disorder.

    PubMed

    Beck-Peccoz, Paolo; Rodari, Giulia; Giavoli, Claudia; Lania, Andrea

    2017-10-01

    Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH. The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both. Moreover, central hypothyroidism can be isolated or combined with other pituitary hormone deficiencies, which are mostly acquired and are rarely congenital. The clinical manifestations of central hypothyroidism are usually milder than those observed in primary hypothyroidism. Obtaining a positive diagnosis for central hypothyroidism can be difficult from both a clinical and a biochemical perspective. The diagnosis of central hypothyroidism is based on low circulating levels of free T4 in the presence of low to normal TSH concentrations. The correct diagnosis of both acquired (also termed sporadic) and congenital (also termed genetic) central hypothyroidism can be hindered by methodological interference in free T4 or TSH measurements; routine utilization of total T4 or T3 measurements; concurrent systemic illness that is characterized by low levels of free T4 and normal TSH concentrations; the use of the sole TSH-reflex strategy, which is the measurement of the sole level of TSH, without free T4, if levels of TSH are in the normal range; and the diagnosis of congenital hypothyroidism based on TSH analysis without the concomitant measurement of serum levels of T4. In this Review, we discuss current knowledge of the causes of central hypothyroidism, emphasizing possible pitfalls in the diagnosis and treatment of this disorder.

  10. Central Hemodynamics for Management of Arteriosclerotic Diseases.

    PubMed

    Hashimoto, Junichiro

    2017-08-01

    Arteriosclerosis, particularly aortosclerosis, is the most critical risk factor associated with cardiovascular, cerebrovascular, and renal diseases. The pulsatile hemodynamics in the central aorta consists of blood pressure, flow, and stiffness and substantially differs from the peripheral hemodynamics in muscular arteries. Arteriosclerotic changes with age appear earlier in the elastic aorta, and age-dependent increases in central pulse pressure are more marked than those apparent from brachial pressure measurement. Central pressure can be affected by lifestyle habits, metabolic disorders, and endocrine and inflammatory diseases in a manner different from brachial pressure. Central pulse pressure widening due to aortic stiffening increases left ventricular afterload in systole and reduces coronary artery flow in diastole, predisposing aortosclerotic patients to myocardial hypertrophy and ischemia. The widened pulse pressure is also transmitted deep into low-impedance organs such as the brain and kidney, causing microvascular damage responsible for lacunar stroke and albuminuria. In addition, aortic stiffening increases aortic blood flow reversal, which can lead to retrograde embolic stroke and renal function deterioration. Central pressure has been shown to predict cardiovascular events in most previous studies and potentially serves as a surrogate marker for intervention. Quantitative and comprehensive evaluation of central hemodynamics is now available through various noninvasive pressure/flow measurement modalities. This review will focus on the clinical usefulness and mechanistic rationale of central hemodynamic measurements for cardiovascular risk management.

  11. DrugCentral: online drug compendium

    PubMed Central

    Ursu, Oleg; Holmes, Jayme; Knockel, Jeffrey; Bologa, Cristian G.; Yang, Jeremy J.; Mathias, Stephen L.; Nelson, Stuart J.; Oprea, Tudor I.

    2017-01-01

    DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies. Monitoring of regulatory agencies for new drugs approvals ensures the resource is up-to-date. DrugCentral integrates content for active ingredients with pharmaceutical formulations, indexing drugs and drug label annotations, complementing similar resources available online. Its complementarity with other online resources is facilitated by cross referencing to external resources. At the molecular level, DrugCentral bridges drug-target interactions with pharmacological action and indications. The integration with FDA drug labels enables text mining applications for drug adverse events and clinical trial information. Chemical structure overlap between DrugCentral and five online drug resources, and the overlap between DrugCentral FDA-approved drugs and their presence in four different chemical collections, are discussed. DrugCentral can be accessed via the web application or downloaded in relational database format. PMID:27789690

  12. Centralized drug review processes: are they fair?

    PubMed

    Mitton, Craig R; McMahon, Meghan; Morgan, Steve; Gibson, Jennifer

    2006-07-01

    Numerous countries have implemented centralized drug review processes to assist in making drug coverage decisions. In addition to examining the final recommendations of these bodies, it is also important to ensure fairness in decision making. Accountability for reasonableness is an ethics-based framework for examining the fairness of priority setting processes. The objective of this study was to assess the fairness of four internationally established centralized drug review processes using accountability for reasonableness. Semi-structured telephone interviews were conducted with stakeholders in Canada, New Zealand, Australia and the UK (n=16). Participants were asked to evaluate their country's centralized drug review process against the four conditions of accountability for reasonableness. Each centralized drug review process satisfied at least one of the four ethical conditions, but none satisfied all four conditions. All participants viewed transparency as critical to both the legitimacy and fairness of centralized drug review processes. Additional strides need to be made in each of the four countries under study to improve the fairness of their centralized drug review processes. Ideally, a fair priority setting process should foster constructive stakeholder engagement and enhance the legitimacy of decisions made in assessing pharmaceutical products for funding. As policy makers are under increasing scrutiny in allocating limited resources, fair process should be seen as a critical component of such activity. This study represents the first attempt to conduct an international comparison of the fairness of centralized drug review agencies in the eyes of participating stakeholders.

  13. XNAT Central: Open sourcing imaging research data.

    PubMed

    Herrick, Rick; Horton, William; Olsen, Timothy; McKay, Michael; Archie, Kevin A; Marcus, Daniel S

    2016-01-01

    XNAT Central is a publicly accessible medical imaging data repository based on the XNAT open-source imaging informatics platform. It hosts a wide variety of research imaging data sets. The primary motivation for creating XNAT Central was to provide a central repository to host and provide access to a wide variety of neuroimaging data. In this capacity, XNAT Central hosts a number of data sets from research labs and investigative efforts from around the world, including the OASIS Brains imaging studies, the NUSDAST study of schizophrenia, and more. Over time, XNAT Central has expanded to include imaging data from many different fields of research, including oncology, orthopedics, cardiology, and animal studies, but continues to emphasize neuroimaging data. Through the use of XNAT's DICOM metadata extraction capabilities, XNAT Central provides a searchable repository of imaging data that can be referenced by groups, labs, or individuals working in many different areas of research. The future development of XNAT Central will be geared towards greater ease of use as a reference library of heterogeneous neuroimaging data and associated synthetic data. It will also become a tool for making data available supporting published research and academic articles.

  14. Central Hemodynamics for Management of Arteriosclerotic Diseases

    PubMed Central

    2017-01-01

    Arteriosclerosis, particularly aortosclerosis, is the most critical risk factor associated with cardiovascular, cerebrovascular, and renal diseases. The pulsatile hemodynamics in the central aorta consists of blood pressure, flow, and stiffness and substantially differs from the peripheral hemodynamics in muscular arteries. Arteriosclerotic changes with age appear earlier in the elastic aorta, and age-dependent increases in central pulse pressure are more marked than those apparent from brachial pressure measurement. Central pressure can be affected by lifestyle habits, metabolic disorders, and endocrine and inflammatory diseases in a manner different from brachial pressure. Central pulse pressure widening due to aortic stiffening increases left ventricular afterload in systole and reduces coronary artery flow in diastole, predisposing aortosclerotic patients to myocardial hypertrophy and ischemia. The widened pulse pressure is also transmitted deep into low-impedance organs such as the brain and kidney, causing microvascular damage responsible for lacunar stroke and albuminuria. In addition, aortic stiffening increases aortic blood flow reversal, which can lead to retrograde embolic stroke and renal function deterioration. Central pressure has been shown to predict cardiovascular events in most previous studies and potentially serves as a surrogate marker for intervention. Quantitative and comprehensive evaluation of central hemodynamics is now available through various noninvasive pressure/flow measurement modalities. This review will focus on the clinical usefulness and mechanistic rationale of central hemodynamic measurements for cardiovascular risk management. PMID:28603219

  15. Report of the Central Tracking Group

    SciTech Connect

    Cassel, D.G.; Hanson, G.G.

    1986-10-01

    Issues involved in building a realistic central tracking system for a general-purpose 4..pi.. detector for the SSC are addressed. Such a central tracking system must be capable of running at the full design luminosity of 10/sup 33/ cm/sup -2/s/sup -1/. Momentum measurement was required in a general-purpose 4..pi.. detector. Limitations on charged particle tracking detectors at the SSC imposed by rates and radiation damage are reviewed. Cell occupancy is the dominant constraint, which led us to the conclusion that only small cells, either wires or straw tubes, are suitable for a central tracking system at the SSC. Mechanical problems involved in building a central tracking system of either wires or straw tubes were studied, and our conclusion was that it is possible to build such a large central tracking system. Of course, a great deal of research and development is required. We also considered central tracking systems made of scintillating fibers or silicon microstrips, but our conclusion was that neither is a realistic candidate given the current state of technology. We began to work on computer simulation of a realistic central tracking system. Events from interesting physics processes at the SSC will be complex and will be further complicated by hits from out-of-time bunch crossings and multiple interactions within the same bunch crossing. Detailed computer simulations are needed to demonstrate that the pattern recognition and tracking problems can be solved.

  16. [WN] central stars of planetary nebulae

    NASA Astrophysics Data System (ADS)

    Todt, H.; Peña, M.; Hamann, W.-R.; Gräfener, G.

    2010-11-01

    Hydrogen-deficient central stars are commonly considered as the progenitors of H-deficient white dwarfs. Spectroscopically, many H-deficient central stars resemble massive Wolf-Rayet stars of the carbon sequence and are therefore classified as [WC] stars. The massive WR stars of the nitrogen sequence (WN), however, have no spectroscopic counterpart among the central stars. With PB 8 we found for the first time a central star with a WR-type emission line spectrum that resembles the nitrogen sequence with only a slight enhancement of carbon lines, and therefore we classified this star as [WN/C]. Our analysis reveals that its atmosphere consists mainly of helium, with some hydrogen and only traces of carbon, nitrogen, and oxygen. This is very different from any other Wolf-Rayet type central stars. The results of our analyses, especially the chemical composition, strongly constrains possible scenarios for the formation of PB 8. For the time being, we don't know any path of single-star evolution that could explain this enigmatic central star. In this context, we will also discuss the status of the central star of PMR 5, which is another candidate for a [WN] spectral type.

  17. Current and future centrally acting antitussives☆

    PubMed Central

    Bolser, Donald C.

    2011-01-01

    The purpose of this review is to highlight some important issues regarding current centrally acting antitussive drugs as well as discuss the implications of these matters on the development of future cough suppressants. Drugs that act in the central nervous system to inhibit cough are termed centrally acting and this designation is based exclusively on evidence obtained from animal models. This classification can include drugs that act both at peripheral and central sites following systemic administration. These drugs are intended to reduce the frequency and/or intensity of coughing resulting from disorders of any etiology. There are a number of central cough suppressants identified by their efficacy in animal models and the most prominent of these are codeine and dextromethorphan. Although the exact neural elements on which these drugs act are currently unknown, they are thought to inhibit a functionally identified component of the central system for cough known as the gating mechanism. The efficacy of codeine and dextromethorphan in humans has recently been questioned. These drugs are less effective on cough induced by upper airway disorders than in pathological conditions involving the lower airways in humans. The reasons for this difference in antitussive sensitivity are not clear. We propose that sensory afferents from different regions of the airways actuate coughing in humans by antitussive sensitive and insensitive control elements in the central nervous system. This hypothesis is consistent with results from an animal model in which laryngeal and tracheobronchial cough had different sensitivities to codeine. Other factors that may be very important in the action of central antitussive drugs in humans include the role of sensations produced by a tussigenic stimulus as well as plasticity of central pathways in response to airway inflammation. Resolution of these issues in the human will be a challenging process, but one which will lay the foundation for the

  18. Communication - An Effective Tool for Implementing ISO 14001/EMS

    SciTech Connect

    Rachel Damewood; Bowen Huntsman

    2004-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) received ISO 14001/EMS certification in June 2002. Communication played an effective role in implementing ISO 14001/EMS at the INEEL. This paper describes communication strategies used during the implementation and certification processes. The INEEL achieved Integrated Safety Management System (ISMS) and Voluntary Protection Program (VPP) Star status in 2001. ISMS implemented a formal process to plan and execute work. VPP facilitated worker involvement by establishing geographic units at various facilities with employee points of contact and management champions. The INEEL Environmental Management System (EMS) was developed to integrate the environmental functional area into its ISMS and VPP. Since the core functions of ISMS, VPP, and EMS are interchangeable, they were easy to integrate. Communication is essential to successfully implement an EMS. (According to ISO 14001 requirements, communication interacts with 12 other elements of the requirements.) We developed communication strategies that integrated ISMS, VPP, and EMS. For example, the ISMS, VPP, and EMS Web sites communicated messages to the work force, such as “VPP emphasizes the people side of doing business, ISMS emphasizes the system side of doing business, and EMS emphasizes the systems to protect the environment; but they all define work, identify and analyze hazards, and mitigate the hazards.” As a result of this integration, the work force supported and implemented the EMS. In addition, the INEEL established a cross-functional communication team to assist with implementing the EMS. The team included members from the Training and Communication organizations, VPP office, Pollution Prevention, Employee and Media Relations, a union representative, facility environmental support, and EMS staff. This crossfunctional team used various communication strategies to promote our EMS to all organization levels and successfully implemented EMS

  19. [Functional anatomy of the central nervous system].

    PubMed

    Krainik, A; Feydy, A; Colombani, J M; Hélias, A; Menu, Y

    2003-03-01

    The central nervous system (CNS) has a particular regional functional anatomy. The morphological support of cognitive functions can now be depicted using functional imaging. Lesions of the central nervous system may be responsible of specific symptoms based on their location. Current neuroimaging techniques are able to show and locate precisely macroscopic lesions. Therefore, the knowledge of functional anatomy of the central nervous system is useful to link clinical disorders to symptomatic lesions. Using radio-clinical cases, we present the functional neuro-anatomy related to common cognitive impairments.

  20. Central serous chorioretinopathy after solar eclipse viewing.

    PubMed

    Lee, Allie; Lai, Timothy Y Y

    2010-07-01

    To report a case of central serous chorioretinopathy after solar eclipse viewing. A middle-age man developed a sudden-onset unilateral scotoma after viewing a partial solar eclipse in Hong Kong. Fundus examination, fluorescein angiography, and optical coherence tomography showed features compatible with central serous chorioretinopathy. The patient was managed conservatively and reevaluated periodically. Serial optical coherence tomographic evaluations demonstrated an initial increase in the amount of subretinal fluid which spontaneously resolved 10 weeks after the onset of symptoms. This case demonstrates the possibility of development of central serous chorioretinopathy following solar eclipse viewing.

  1. [Mechanical complication of central venous catheterization].

    PubMed

    Koja, Hiroki; Tokumine, Joho; Sugahara, Kazuhiro

    2007-01-01

    Central venous catheterization is a procedure with a high success rate. However, life-threatening complications are occasionally caused by mechanical injury during the catheterization process. Therefore, surgeons should have sufficient knowledge of the potential complications and the effective use of preventative measures when performing catheterization. We herein review and discuss the mechanical complications previously reported to have occurred in association with central venous catheterization. Comprehensive knowledge about various complication-inducing factors, the ability to make a quick and accurate diagnosis of such complications, and sufficient skill to prevent worsening of these complications can thus help patients from suffering lethal complications due to central venous catheterization.

  2. Central Serous Chorioretinopathy after Solar Eclipse Viewing

    PubMed Central

    Lee, Allie; Lai, Timothy Y Y

    2010-01-01

    Purpose To report a case of central serous chorioretinopathy after solar eclipse viewing. Case Report A middle-age man developed a sudden-onset unilateral scotoma after viewing a partial solar eclipse in Hong Kong. Fundus examination, fluorescein angiography, and optical coherence tomography showed features compatible with central serous chorioretinopathy. The patient was managed conservatively and reevaluated periodically. Serial optical coherence tomographic evaluations demonstrated an initial increase in the amount of subretinal fluid which spontaneously resolved 10 weeks after the onset of symptoms. Conclusion This case demonstrates the possibility of development of central serous chorioretinopathy following solar eclipse viewing. PMID:22737356

  3. Central black hole masses of galaxies

    NASA Astrophysics Data System (ADS)

    Fan, Jun-Hui

    2003-11-01

    In this paper, the stellar velocity dispersions in the host galaxies are used to estimate the central black hole masses for a sample of elliptical galaxies. We find that the central black hole masses are in the range of 10(5.5-9.5)Modot. Based on the estimated masses in this paper and those by Woo & Urry (2002) and the measured host galaxy absolute magnitude, a relation, log (MBH/Modot) = -(0.25±4.3×10-3)MR + (2.98±0.208) is found for central black hole mass and the host galaxy magnitude. Some discussions are presented.

  4. Cellular Mechanisms of Central Nervous Modulation.

    DTIC Science & Technology

    1983-06-30

    achieve selective disruption of the neuroglia in the central nervous system 4 of our experimental animal, the cockroach (Periplaneta americana). Such...RD-A147 878 CELLULAR MECHANISMIS OF CENTRAL NERVOUS MODULATION(U) i/i I CAMBRIDGE UNIV (ENGLAND) DEPT OF ZOOLOGY J E TRENERNE 30 JUN 83 DHJA37-8i-C...BOOBI UNCLASSFE F/G 6/16 NL bi L& 2. MICROCOPY RESOLUTION TEST CHART NATIONA BUJREAUJ OF STANDOW-S1963-A [.1 PI CELLULAR MECHANISMIS OF CENTRAL NERVOUS

  5. Cellular Mechanisms of Central Nervous Modulation.

    DTIC Science & Technology

    1981-12-31

    Schofield, P.K. (1981) Mechanism of ionic homeostasis in the central nervous system of an insect. J. exp. Biol., 95, 61-73. Treherne, J.E., Schofield...P.K. & Lane, N.J. (1982) Physiological and ultra- structural evidence for an extracellular anion matrix in the central nervous system of an insect...AD-R147 875 CELLULAR MECHANISM1S OF CENTRAL NERVOUS tODULATION(U) I/i CAMBRIDGE UNIV (ENGLAND) DEPT OF ZOOLOGY J E TREHERNE 31 DEC 81 DAJA37-Si-C

  6. Erroneous laboratory values obtained from central catheters.

    PubMed

    Johnston, J B; Messina, M

    1991-01-01

    Serious analytic errors in potassium measurements have been identified in blood specimens obtained from newly inserted central catheters. Erroneous elevated readings have been related to interactions of chemistry analyzer electrodes and substances fixed to external and intraluminal walls of the central catheter. Anecdotal summaries of this phenomenon are presented to enable the nurse to recognize potential problems when sampling blood from central catheters. Studies were performed to determine the amount of flush necessary to clear the catheter of interfering residue. To eliminate this potentially hazardous occurrence, recommended flush volumes, nursing implications, and actions are described.

  7. EM threat analysis for wireless systems.

    SciTech Connect

    Burkholder, R. J. (Ohio State University Electroscience Laboratory); Mariano, Robert J.; Schniter, P. (Ohio State University Electroscience Laboratory); Gupta, I. J. (Ohio State University Electroscience Laboratory)

    2006-06-01

    Modern digital radio systems are complex and must be carefully designed, especially when expected to operate in harsh propagation environments. The ability to accurately predict the effects of propagation on wireless radio performance could lead to more efficient radio designs as well as the ability to perform vulnerability analyses before and after system deployment. In this report, the authors--experts in electromagnetic (EM) modeling and wireless communication theory--describe the construction of a simulation environment that is capable of quantifying the effects of wireless propagation on the performance of digital communication.

  8. Association between EMS Question Bank Completion and Passing Rates on the EMS Certification Examination.

    PubMed

    Clemency, Brian; Martin-Gill, Christian; Rall, Nicole; May, Paul; Lubin, Jeffrey; Cooley, Craig; Van Dillen, Christine; Silvestri, Salvatore; Portela, Roberto; Cooney, Derek; Knutsen, Christian; March, Juan

    2017-01-01

    A board review question bank was created to assist candidates in their preparation for the 2015 EMS certification examination. We aimed to describe the development of this question bank and evaluate its successes in preparing candidates to obtain EMS subspecialty board certification. An online question bank was developed by 13 subject matter experts who participated as item writers, representing eight different EMS fellowship programs. The online question bank consisted of four practice tests, with each of the tests comprised of 100 questions. The number of candidates who participated in and completed the question bank was calculated. The passing rate among candidates who completed the question bank was calculated and compared to the publicly reported statistics for all candidates. The relationship between candidates' performance on the question bank and subspecialty exam pass rates was determined. A total of 252 candidates took at least one practice test and, of those, 225 candidates completed all four 100-question practice tests. The pass rate on the 2015 EMS certification exam was 79% (95%CI 74-85%) among candidates who completed the question bank, which is 12% higher than the overall pass rate (p = 0.003). Candidates' performance on the question bank was positively associated with overall success on the exam (X(2) = 75.8, p < 0.0001). Achieving a score of ≥ 70% on the question bank was associated with a higher likelihood of passing the exam (OR = 17.8; 95% CI: 8.0-39.6). Completing the question bank program was associated with improved pass rates on the EMS certification exam. Strong performance on the question bank correlated with success on the exam.

  9. Colorful Central Peak in an Unnamed Crater

    NASA Image and Video Library

    2011-10-05

    The colorful rocks exposed in the central peak visible in this image from NASA Mars Reconnaissance Orbiter probably reflect variations in mineral content that were caused by water activity early in Mars history.

  10. Cohomological invariants of central simple algebras

    NASA Astrophysics Data System (ADS)

    Merkurjev, A. S.

    2016-10-01

    We determine the indecomposable degree 3 cohomological invariants of tuples of central simple algebras with linear relations. Equivalently, we determine the degree 3 reductive cohomological invariants of all split semisimple groups of type A.

  11. NCI Central Review Board Receives Accreditation

    Cancer.gov

    The Association for the Accreditation of Human Research Protection Programs has awarded the NCI Central Institutional Review Board full accreditation. AAHRPP awards accreditation to organizations demonstrating the highest ethical standards in clinical res

  12. Centralized Copying Saves Time and Money.

    ERIC Educational Resources Information Center

    Benson, Paul

    1996-01-01

    Describes how Deer Park School District, Long Island, New York, is saving money while boosting efficiency by centralizing its high-volume printing and duplicating operations. The new arrangement saves space, time, and expenses. (LMI)

  13. Genetics and diagnosis of central diabetes insipidus.

    PubMed

    Bichet, Daniel G

    2012-04-01

    Most of the central diabetes insipidus cases seen in general practice are acquired but the rare cases of hereditary autosomal dominant or recessive neurohypophyseal diabetes insipidus have provided further cellular understanding of the mechanisms responsible for pre-hormone folding, maturation and release. Autosomal dominant central diabetes insipidus is secondary to the toxic accumulation of vasopressin mutants as fibrillar aggregates in the endoplasmic reticulum of hypothalamic magnocellular neurons producing vasopressin. As well, Trpv1(-/-) and Trpv4(-/-) mice have shed new light on the perception of tonicity through the stretch receptors TRPVs expressed both in central and peripheral neurons. The genomic information provided by sequencing the AVP gene is key to the routine care of these patients and, as in other genetic diseases, reduces health costs and provides psychological benefits to patients and families. In addition, simple, inexpensive blood and urine measurements together with clinical characteristics and brain magnetic resonance imaging (MRI) could distinguish between central, nephrogenic and polydipsic cases.

  14. Centralized Copying Saves Time and Money.

    ERIC Educational Resources Information Center

    Benson, Paul

    1996-01-01

    Describes how Deer Park School District, Long Island, New York, is saving money while boosting efficiency by centralizing its high-volume printing and duplicating operations. The new arrangement saves space, time, and expenses. (LMI)

  15. Genetics Home Reference: central precocious puberty

    MedlinePlus

    ... girls and between ages 9 and 14 in boys, girls with central precocious puberty begin exhibiting signs before ... of puberty is even earlier than normal in girls than in boys. Boys with an MKRN3 gene mutation inherited from ...

  16. Random walk centrality in interconnected multilayer networks

    NASA Astrophysics Data System (ADS)

    Solé-Ribalta, Albert; De Domenico, Manlio; Gómez, Sergio; Arenas, Alex

    2016-06-01

    Real-world complex systems exhibit multiple levels of relationships. In many cases they require to be modeled as interconnected multilayer networks, characterizing interactions of several types simultaneously. It is of crucial importance in many fields, from economics to biology and from urban planning to social sciences, to identify the most (or the less) influent nodes in a network using centrality measures. However, defining the centrality of actors in interconnected complex networks is not trivial. In this paper, we rely on the tensorial formalism recently proposed to characterize and investigate this kind of complex topologies, and extend two well known random walk centrality measures, the random walk betweenness and closeness centrality, to interconnected multilayer networks. For each of the measures we provide analytical expressions that completely agree with numerically results.

  17. Francis Crick, DNA, and the Central Dogma

    ERIC Educational Resources Information Center

    Olby, Robert

    1970-01-01

    This essay describes how Francis Crick, ex-physicist, entered the field of biology and discovered the structure of DNA. Emphasis is upon the double helix, the sequence hypothesis, the central dogma, and the genetic code. (VW)

  18. Central exclusive production and the Durham model

    NASA Astrophysics Data System (ADS)

    Harland-Lang, L. A.; Khoze, V. A.; Ryskin, M. G.

    2014-11-01

    We review some selected results within the Durham model of central exclusive production. We discuss the theoretical aspects of this approach and consider the phenomenological implications for a selection of processes.

  19. A perturbative approach to central exclusive production

    NASA Astrophysics Data System (ADS)

    Harland-Lang, L. A.; Khoze, V. A.; Ryskin, M. G.

    2015-02-01

    We review some selected results within the Durham model of central exclusive production. We present a detailed discussion of this theoretical approach for modeling exclusive processes and we briefly review some of its phenomenological applications.

  20. Central respiratory failure during acute organophosphate poisoning.

    PubMed

    Carey, Jennifer L; Dunn, Courtney; Gaspari, Romolo J

    2013-11-01

    Organophosphate (OP) pesticide poisoning is a global health problem with over 250,000 deaths per year. OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Mortality due to OP agents is attributed to respiratory dysfunction, including central apnea. Cholinergic circuits are integral to many aspects of the central control of respiration, however it is unclear which mechanisms predominate during acute OP intoxication. A more complete understanding of the cholinergic aspects of both respiratory control as well as neural modification of pulmonary function is needed to better understand OP-induced respiratory dysfunction. In this article, we review the physiologic mechanisms of acute OP exposure in the context of the known cholinergic contributions to the central control of respiration. We also discuss the potential central cholinergic contributions to the known peripheral physiologic effects of OP intoxication.

  1. Francis Crick, DNA, and the Central Dogma

    ERIC Educational Resources Information Center

    Olby, Robert

    1970-01-01

    This essay describes how Francis Crick, ex-physicist, entered the field of biology and discovered the structure of DNA. Emphasis is upon the double helix, the sequence hypothesis, the central dogma, and the genetic code. (VW)

  2. Overview of Glutamatergic Dysregulation in Central Pathologies

    PubMed Central

    Miladinovic, Tanya; Nashed, Mina G.; Singh, Gurmit

    2015-01-01

    As the major excitatory neurotransmitter in the mammalian central nervous system, glutamate plays a key role in many central pathologies, including gliomas, psychiatric, neurodevelopmental, and neurodegenerative disorders. Post-mortem and serological studies have implicated glutamatergic dysregulation in these pathologies, and pharmacological modulation of glutamate receptors and transporters has provided further validation for the involvement of glutamate. Furthermore, efforts from genetic, in vitro, and animal studies are actively elucidating the specific glutamatergic mechanisms that contribute to the aetiology of central pathologies. However, details regarding specific mechanisms remain sparse and progress in effectively modulating glutamate to alleviate symptoms or inhibit disease states has been relatively slow. In this report, we review what is currently known about glutamate signalling in central pathologies. We also discuss glutamate’s mediating role in comorbidities, specifically cancer-induced bone pain and depression. PMID:26569330

  3. Central Station DHC Phase 1 feasibility

    SciTech Connect

    Henderson, H.L.

    1992-03-01

    This project assisted a private real estate developer in technically assessing the feasibility of integrating a central DHC system into a proposed 72 acre area mixed-use Planned Development (Central Station) just south of the Chicago Central Business District (Loop). The technical assessment concluded that a district heating and cooling system for Central Station will be feasible, provided that a major anchor load can be connected to the system. The system conceived for the site employs a modular approach that adjusts production capacity to actual load growth. The design concept includes gas-fired boilers for heating, gas turbine driven chillers for base loading, electric motor driven chillers for peaking, steam turbines for peak power and back pressure operation, and chilled water storage. Energy will be supplied to the users in the form of steam or low temperature hot water for heating, and low temperature chilled water for cooling.

  4. Proceedings. 14th Central Hardwood Forest Conference

    Treesearch

    Daniel A. Yaussy; David M. Hix; Robert P. Long; P. Charles, eds. Goebel

    2004-01-01

    Proceedings of the 14th Central Hardwood Forest conference held 16-19 March in Wooster Ohio. Includes 102 papers and abstracts dealing with silviculture, wildlife, human dimensions, harvesting and utilization, physiology, genetics, soils, nutrient cycling, and biometrics.

  5. Initial TMX central-cell ICRH experiments

    SciTech Connect

    Molvik, A.W.; Coffield, F.E.; Falabella, S.; Griffin, D.; McVey, B.; Pickles, W.; Poulsen, P.; Simonen, T.C.; Yugo, J.

    1980-12-09

    Four topics are discussed in this report: the feasibility of applying ion cyclotron resonance heating (ICRH) in the TMX central cell, some applications of heating, the results of preliminary experiments, and plans for further ICRH experiments.

  6. The CMS central hadron calorimeter: Update

    SciTech Connect

    Freeman, J.

    1998-06-01

    The CMS central hadron calorimeter is a brass absorber/ scintillator sampling structure. We describe details of the mechanical and optical structure. We also discuss calibration techniques, and finally the anticipated construction schedule.

  7. Space Radar Image of Tuva, Central Asia

    NASA Image and Video Library

    1999-04-15

    This spaceborne radar image shows part of the remote central Asian region of Tuva, an autonomous republic of the Russian Federation. Tuva is a mostly mountainous region that lies between western Mongolia and southern Siberia.

  8. Light curve analysis of southern eclipsing binary EM Car

    NASA Astrophysics Data System (ADS)

    Ćiçek, C.; Bulut, I.; Bulut, A.

    2017-02-01

    In this study, ASAS light curve of the eclipsing binary EM Car (Sp = O8V, P = 3.4 days) has been analyzed using the Wilson-Devinney method. The light curve analyses have found that EM Car is a detached eclipsing binary system with small eccentric orbit

  9. Genetic-based EM algorithm for learning Gaussian mixture models.

    PubMed

    Pernkopf, Franz; Bouchaffra, Djamel

    2005-08-01

    We propose a genetic-based expectation-maximization (GA-EM) algorithm for learning Gaussian mixture models from multivariate data. This algorithm is capable of selecting the number of components of the model using the minimum description length (MDL) criterion. Our approach benefits from the properties of Genetic algorithms (GA) and the EM algorithm by combination of both into a single procedure. The population-based stochastic search of the GA explores the search space more thoroughly than the EM method. Therefore, our algorithm enables escaping from local optimal solutions since the algorithm becomes less sensitive to its initialization. The GA-EM algorithm is elitist which maintains the monotonic convergence property of the EM algorithm. The experiments on simulated and real data show that the GA-EM outperforms the EM method since: 1) We have obtained a better MDL score while using exactly the same termination condition for both algorithms. 2) Our approach identifies the number of components which were used to generate the underlying data more often than the EM algorithm.

  10. CryoEM at IUCrJ: a new era

    PubMed Central

    Subramaniam, Sriram; Kühlbrandt, Werner; Henderson, Richard

    2016-01-01

    In this overview, we briefly outline recent advances in electron cryomicroscopy (cryoEM) and explain why the journal IUCrJ, published by the International Union of Crystallography, could provide a natural home for publications covering many present and future developments in the cryoEM field. PMID:26870375

  11. 7 CFR 759.6 - EM to be made available.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... natural disaster has occurred in a county, resulting in severe physical losses. If the FSA Administrator determines that such a natural disaster has occurred, then EM can be made available to eligible farmers for... AGRICULTURE SPECIAL PROGRAMS DISASTER DESIGNATIONS AND NOTIFICATIONS § 759.6 EM to be made available. (a)...

  12. 7 CFR 759.6 - EM to be made available.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... natural disaster has occurred in a county, resulting in severe physical losses. If the FSA Administrator determines that such a natural disaster has occurred, then EM can be made available to eligible farmers for... AGRICULTURE SPECIAL PROGRAMS DISASTER DESIGNATIONS AND NOTIFICATIONS § 759.6 EM to be made available. (a)...

  13. A handbook for solar central receiver design

    SciTech Connect

    Falcone, P.K.

    1986-12-01

    This Handbook describes central receiver technology for solar thermal power plants. It contains a description and assessment of the major components in a central receiver system configured for utility scale production of electricity using Rankine-cycle steam turbines. It also describes procedures to size and optimize a plant and discussed examples from recent system analyses. Information concerning site selection criteria, cost estimation, construction, and operation and maintenance is also included, which should enable readers to perform design analyses for specific applications.

  14. Gullies in a Central Pit Crater

    NASA Image and Video Library

    2015-10-14

    Sometimes a central pit forms inside some Martian craters, especially when there substantial ground ice. Such is the case in this observation from NASA Mars Reconnaissance Orbiter spacecraft. Sometimes what we call "mass wasting" processes (think small avalanches or landslides) occur on the slopes of the central pit. We took this image to search for any recent activity that would add to or modify previously identified gullies. http://photojournal.jpl.nasa.gov/catalog/PIA20005

  15. Central neurocytoma: establishment of the disease entity.

    PubMed

    Kim, Dong Gyu; Park, Chul-Kee

    2015-01-01

    The establishment and identification of central neurocytoma as a distinct disease entity are invaluable in catalyzing investigations of neuronal differentiation in central nervous system tumors. The discovery of neuronal differentiation in neuroepithelial tumors has been extended to extraventricular tumors and potentially to various glial tumors undergoing neuronal differentiation. Understanding the disease spectrum of neuronal and mixed neuronal-glial tumors is important for deciphering the mechanism of gliomagenesis. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Midwifery education in Central-Eastern Europe.

    PubMed

    Mivšek, Polona; Baškova, Martina; Wilhelmova, Radka

    2016-02-01

    Problems in midwifery in many Central-Eastern European countries are very similar; it is possible to speak about the evolving Central-Eastern model of midwifery care. The educational models of this region have a relatively strong theoretical part; however, there is an insufficient practical dimension. Theoretical part of midwifery education in the universities is relatively autonomous and is slowly changing the professional identity of graduates.

  17. Collection development at the NOAA Central Library

    NASA Technical Reports Server (NTRS)

    Quillen, Steve R.

    1994-01-01

    The National Oceanic and Atmospheric Administration (NOAA) Central Library collection, approximately one million volumes, incorporates the holdings of its predecessor agencies. Within the library, the collections are filed separately, based on their source and/or classification schemes. The NOAA Central Library provides a variety of services to users, ranging from quick reference and interlibrary loan to in-depth research and online data bases.

  18. Neuropathic Pain: Central vs. Peripheral Mechanisms.

    PubMed

    Meacham, Kathleen; Shepherd, Andrew; Mohapatra, Durga P; Haroutounian, Simon

    2017-06-01

    Our goal is to examine the processes-both central and peripheral-that underlie the development of peripherally-induced neuropathic pain (pNP) and to highlight recent evidence for mechanisms contributing to its maintenance. While many pNP conditions are initiated by damage to the peripheral nervous system (PNS), their persistence appears to rely on maladaptive processes within the central nervous system (CNS). The potential existence of an autonomous pain-generating mechanism in the CNS creates significant implications for the development of new neuropathic pain treatments; thus, work towards its resolution is crucial. Here, we seek to identify evidence for PNS and CNS independently generating neuropathic pain signals. Recent preclinical studies in pNP support and provide key details concerning the role of multiple mechanisms leading to fiber hyperexcitability and sustained electrical discharge to the CNS. In studies regarding central mechanisms, new preclinical evidence includes the mapping of novel inhibitory circuitry and identification of the molecular basis of microglia-neuron crosstalk. Recent clinical evidence demonstrates the essential role of peripheral mechanisms, mostly via studies that block the initially damaged peripheral circuitry. Clinical central mechanism studies use imaging to identify potentially self-sustaining infra-slow CNS oscillatory activity that may be unique to pNP patients. While new preclinical evidence supports and expands upon the key role of central mechanisms in neuropathic pain, clinical evidence for an autonomous central mechanism remains relatively limited. Recent findings from both preclinical and clinical studies recapitulate the critical contribution of peripheral input to maintenance of neuropathic pain. Further clinical investigations on the possibility of standalone central contributions to pNP may be assisted by a reconsideration of the agreed terms or criteria for diagnosing the presence of central sensitization in humans.

  19. Single fibre electromyography in central core disease

    PubMed Central

    Martínez, A. Cruz; Ferrer, M. T.; López-Terradas, J. M.; Pascual-Castroviejo, I.; Mingo, P.

    1979-01-01

    Single fibre electromyography in the extensor digitorum communis muscle was studied in five patients with central core disease. The average number of muscle fibre action potentials belonging to the same motor unit was higher in patients than in healthy subjects of the same age. The increase in motor unit fibre density is consistent with increased terminal innervation ratio described in other papers about central core disease. PMID:479907

  20. Centralizing physician office functions. A paradigm shift.

    PubMed

    Croopnick, J G

    1999-01-01

    Recent trends show that organizations that once thought business office centralization was beneficial are re-thinking their strategies and decentralizing business office functions. This article focuses on the paradigm shift from business office centralization to decentralization and the political factors effecting this shift. It provides actual case summaries to demonstrate what has transpired, and presents an alternative strategy to establishing successful business office functions, a hybrid business office.

  1. Central diffractive resonance production at the LHC

    NASA Astrophysics Data System (ADS)

    Fiore, Roberto; Jenkovszky, Laszlo; Schicker, Rainer

    2016-07-01

    Central production of resonances resulting from the scattering of Pomerons in the central rapidity region of proton-proton scattering is studied. Estimates for relevant cross sections are presented. L.J. gratefully acknowledges an EMMI visiting Professorship at the University of Heidelberg for completion of this work. He is grateful to the organizers of this meeting for their hospitality and support. His work was supported also by DOMUS, Hungarian Academy of Sciences

  2. CENTRAL ROTATIONS OF MILKY WAY GLOBULAR CLUSTERS

    SciTech Connect

    Fabricius, Maximilian H.; Rukdee, Surangkhana; Saglia, Roberto P.; Bender, Ralf; Hopp, Ulrich; Thomas, Jens; Williams, Michael J.; Noyola, Eva; Opitsch, Michael

    2014-06-01

    Most Milky Way globular clusters (GCs) exhibit measurable flattening, even if on a very low level. Both cluster rotation and tidal fields are thought to cause this flattening. Nevertheless, rotation has only been confirmed in a handful of GCs, based mostly on individual radial velocities at large radii. We are conducting a survey of the central kinematics of Galactic GCs using the new Integral Field Unit instrument VIRUS-W. We detect rotation in all 11 GCs that we have observed so far, rendering it likely that a large majority of the Milky Way GCs rotate. We use published catalogs of GCs to derive central ellipticities and position angles. We show that in all cases where the central ellipticity permits an accurate measurement of the position angle, those angles are in excellent agreement with the kinematic position angles that we derive from the VIRUS-W velocity fields. We find an unexpected tight correlation between central rotation and outer ellipticity, indicating that rotation drives flattening for the objects in our sample. We also find a tight correlation between central rotation and published values for the central velocity dispersion, most likely due to rotation impacting the old dispersion measurements.

  3. Central Rotations of Milky Way Globular Clusters

    NASA Astrophysics Data System (ADS)

    Fabricius, Maximilian H.; Noyola, Eva; Rukdee, Surangkhana; Saglia, Roberto P.; Bender, Ralf; Hopp, Ulrich; Thomas, Jens; Opitsch, Michael; Williams, Michael J.

    2014-06-01

    Most Milky Way globular clusters (GCs) exhibit measurable flattening, even if on a very low level. Both cluster rotation and tidal fields are thought to cause this flattening. Nevertheless, rotation has only been confirmed in a handful of GCs, based mostly on individual radial velocities at large radii. We are conducting a survey of the central kinematics of Galactic GCs using the new Integral Field Unit instrument VIRUS-W. We detect rotation in all 11 GCs that we have observed so far, rendering it likely that a large majority of the Milky Way GCs rotate. We use published catalogs of GCs to derive central ellipticities and position angles. We show that in all cases where the central ellipticity permits an accurate measurement of the position angle, those angles are in excellent agreement with the kinematic position angles that we derive from the VIRUS-W velocity fields. We find an unexpected tight correlation between central rotation and outer ellipticity, indicating that rotation drives flattening for the objects in our sample. We also find a tight correlation between central rotation and published values for the central velocity dispersion, most likely due to rotation impacting the old dispersion measurements. This Letter includes data taken at The McDonald Observatory of The University of Texas at Austin.

  4. Dynamics-based centrality for directed networks

    NASA Astrophysics Data System (ADS)

    Masuda, Naoki; Kori, Hiroshi

    2010-11-01

    Determining the relative importance of nodes in directed networks is important in, for example, ranking websites, publications, and sports teams, and for understanding signal flows in systems biology. A prevailing centrality measure in this respect is the PageRank. In this work, we focus on another class of centrality derived from the Laplacian of the network. We extend the Laplacian-based centrality, which has mainly been applied to strongly connected networks, to the case of general directed networks such that we can quantitatively compare arbitrary nodes. Toward this end, we adopt the idea used in the PageRank to introduce global connectivity between all the pairs of nodes with a certain strength. Numerical simulations are carried out on some networks. We also offer interpretations of the Laplacian-based centrality for general directed networks in terms of various dynamical and structural properties of networks. Importantly, the Laplacian-based centrality defined as the stationary density of the continuous-time random walk with random jumps is shown to be equivalent to the absorption probability of the random walk with sinks at each node but without random jumps. Similarly, the proposed centrality represents the importance of nodes in dynamics on the original network supplied with sinks but not with random jumps.

  5. Health challenges in Kazakhstan and Central Asia.

    PubMed

    Adambekov, Shalkar; Kaiyrlykyzy, Aiym; Igissinov, Nurbek; Linkov, Faina

    2016-01-01

    The Central Asian region, which encompasses Kazakhstan, Uzbekistan, Tajikistan, Turkmenistan and Kyrgyzstan, is an interesting geographic region with a rich history dating back to the Silk Road, Mongol conquests and expansion of the Russian Empire. However, from a public health viewpoint, the Central Asian region is under-investigated, and many public health challenges exist, as countries of Central Asia inherited the centralised medical systems practiced in the Soviet Union, and are currently undergoing rapid transitions. A large number of low and middle-income countries around the world, including countries of Central Asia, face a double burden of chronic and infectious disease. This essay focuses on the exploration of the most important public health challenges in the Central Asian region, including limited scientific productivity, the double burden of chronic and infectious disease, the need for healthcare reform and the reduction in care variation. Central Asia has a large number of medical schools, medical centres, and emerging research institutes that can be used to foster a change in medical and public health practice in the region.

  6. Community centrality and social science research.

    PubMed

    Allman, Dan

    2015-12-01

    Community centrality is a growing requirement of social science. The field's research practices are increasingly expected to conform to prescribed relationships with the people studied. Expectations about community centrality influence scholarly activities. These expectations can pressure social scientists to adhere to models of community involvement that are immediate and that include community-based co-investigators, advisory boards, and liaisons. In this context, disregarding community centrality can be interpreted as failure. This paper considers evolving norms about the centrality of community in social science. It problematises community inclusion and discusses concerns about the impact of community centrality on incremental theory development, academic integrity, freedom of speech, and the value of liberal versus communitarian knowledge. Through the application of a constructivist approach, this paper argues that social science in which community is omitted or on the periphery is not failed science, because not all social science requires a community base to make a genuine and valuable contribution. The utility of community centrality is not necessarily universal across all social science pursuits. The practices of knowing within social science disciplines may be difficult to transfer to a community. These practices of knowing require degrees of specialisation and interest that not all communities may want or have.

  7. Velocardiofacial syndrome with single central incisor.

    PubMed

    Oberoi, Snehlata; Vargervik, Karin

    2005-01-15

    Three siblings and their mother are reported who all had cytogenetically proven velocardiofacial syndrome (VCFS). One boy had normal dental and craniofacial findings, except for an increased cranial base angle. His sister had only one central incisor in the maxilla. One central incisor had also been missing in the primary dentition. She had no labial frenulum present. Cephalometry showed a small maxillary unit length indicating mild maxillary hypoplasia, an increased anterior face height, steep mandibular plane angle, retruded chin, and a large cranial base angle. Dental measurements showed retroclined lower incisors and increased interincisal angle. A second sister had a cleft of the secondary palate. All permanent teeth were present with the exception of a missing central incisor in the lower jaw: the single lower central incisor was situated in the midline. Her cephalometry showed similar findings as in her sister. All three siblings required palate surgery for speech. Mother was not available for detailed dental and other oral investigations. A single maxillary central incisor has previously been reported in VCFS, but to our knowledge a single central incisor in the mandible has not been reported previously in this entity.

  8. Central auditory function of deafness genes.

    PubMed

    Willaredt, Marc A; Ebbers, Lena; Nothwang, Hans Gerd

    2014-06-01

    The highly variable benefit of hearing devices is a serious challenge in auditory rehabilitation. Various factors contribute to this phenomenon such as the diversity in ear defects, the different extent of auditory nerve hypoplasia, the age of intervention, and cognitive abilities. Recent analyses indicate that, in addition, central auditory functions of deafness genes have to be considered in this context. Since reduced neuronal activity acts as the common denominator in deafness, it is widely assumed that peripheral deafness influences development and function of the central auditory system in a stereotypical manner. However, functional characterization of transgenic mice with mutated deafness genes demonstrated gene-specific abnormalities in the central auditory system as well. A frequent function of deafness genes in the central auditory system is supported by a genome-wide expression study that revealed significant enrichment of these genes in the transcriptome of the auditory brainstem compared to the entire brain. Here, we will summarize current knowledge of the diverse central auditory functions of deafness genes. We furthermore propose the intimately interwoven gene regulatory networks governing development of the otic placode and the hindbrain as a mechanistic explanation for the widespread expression of these genes beyond the cochlea. We conclude that better knowledge of central auditory dysfunction caused by genetic alterations in deafness genes is required. In combination with improved genetic diagnostics becoming currently available through novel sequencing technologies, this information will likely contribute to better outcome prediction of hearing devices.

  9. Community centrality and social science research

    PubMed Central

    Allman, Dan

    2015-01-01

    Community centrality is a growing requirement of social science. The field's research practices are increasingly expected to conform to prescribed relationships with the people studied. Expectations about community centrality influence scholarly activities. These expectations can pressure social scientists to adhere to models of community involvement that are immediate and that include community-based co-investigators, advisory boards, and liaisons. In this context, disregarding community centrality can be interpreted as failure. This paper considers evolving norms about the centrality of community in social science. It problematises community inclusion and discusses concerns about the impact of community centrality on incremental theory development, academic integrity, freedom of speech, and the value of liberal versus communitarian knowledge. Through the application of a constructivist approach, this paper argues that social science in which community is omitted or on the periphery is not failed science, because not all social science requires a community base to make a genuine and valuable contribution. The utility of community centrality is not necessarily universal across all social science pursuits. The practices of knowing within social science disciplines may be difficult to transfer to a community. These practices of knowing require degrees of specialisation and interest that not all communities may want or have. PMID:26440071

  10. Cryo-EM Structure of the TOM Core Complex from Neurospora crassa.

    PubMed

    Bausewein, Thomas; Mills, Deryck J; Langer, Julian D; Nitschke, Beate; Nussberger, Stephan; Kühlbrandt, Werner

    2017-08-10

    The TOM complex is the main entry gate for protein precursors from the cytosol into mitochondria. We have determined the structure of the TOM core complex by cryoelectron microscopy (cryo-EM). The complex is a 148 kDa symmetrical dimer of ten membrane protein subunits that create a shallow funnel on the cytoplasmic membrane surface. In the core of the dimer, the β-barrels of the Tom40 pore form two identical preprotein conduits. Each Tom40 pore is surrounded by the transmembrane segments of the α-helical subunits Tom5, Tom6, and Tom7. Tom22, the central preprotein receptor, connects the two Tom40 pores at the dimer interface. Our structure offers detailed insights into the molecular architecture of the mitochondrial preprotein import machinery. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

    PubMed Central

    Zhou, Anna; Rohou, Alexis; Schep, Daniel G; Bason, John V; Montgomery, Martin G; Walker, John E; Grigorieff, Nikolaus; Rubinstein, John L

    2015-01-01

    Adenosine triphosphate (ATP), the chemical energy currency of biology, is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic mechanism where proton translocation through the membrane-inserted FO region is coupled to ATP synthesis in the catalytic F1 region via rotation of a central rotor subcomplex. We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining cryo-EM data with bioinformatic analysis allowed us to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits. 3D classification of images revealed seven distinct states of the enzyme that show different modes of bending and twisting in the intact ATP synthase. Rotational fluctuations of the c8-ring within the FO region support a Brownian ratchet mechanism for proton-translocation-driven rotation in ATP synthases. DOI: http://dx.doi.org/10.7554/eLife.10180.001 PMID:26439008

  12. The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

    PubMed Central

    Bai, Xiao-Chen; Yan, Zhen; Wu, Jianping; Li, Zhangqiang; Yan, Nieng

    2016-01-01

    The ryanodine receptors (RyRs) are intracellular calcium channels responsible for rapid release of Ca2+ from the sarcoplasmic/endoplasmic reticulum (SR/ER) to the cytoplasm, which is essential for the excitation-contraction (E-C) coupling of cardiac and skeletal muscles. The near-atomic resolution structure of closed RyR1 revealed the molecular details of this colossal channel, while the long-range allosteric gating mechanism awaits elucidation. Here, we report the cryo-EM structures of rabbit RyR1 in three closed conformations at about 4 Å resolution and an open state at 5.7 Å. Comparison of the closed RyR1 structures shows a breathing motion of the cytoplasmic platform, while the channel domain and its contiguous Central domain remain nearly unchanged. Comparison of the open and closed structures shows a dilation of the S6 tetrahelical bundle at the cytoplasmic gate that leads to channel opening. During the pore opening, the cytoplasmic “O-ring” motif of the channel domain and the U-motif of the Central domain exhibit coupled motion, while the Central domain undergoes domain-wise displacement. These structural analyses provide important insight into the E-C coupling in skeletal muscles and identify the Central domain as the transducer that couples the conformational changes of the cytoplasmic platform to the gating of the central pore. PMID:27468892

  13. Perturbation Centrality and Turbine: A Novel Centrality Measure Obtained Using a Versatile Network Dynamics Tool

    PubMed Central

    Szalay, Kristóf Z.; Csermely, Peter

    2013-01-01

    Analysis of network dynamics became a focal point to understand and predict changes of complex systems. Here we introduce Turbine, a generic framework enabling fast simulation of any algorithmically definable dynamics on very large networks. Using a perturbation transmission model inspired by communicating vessels, we define a novel centrality measure: perturbation centrality. Hubs and inter-modular nodes proved to be highly efficient in perturbation propagation. High perturbation centrality nodes of the Met-tRNA synthetase protein structure network were identified as amino acids involved in intra-protein communication by earlier studies. Changes in perturbation centralities of yeast interactome nodes upon various stresses well recapitulated the functional changes of stressed yeast cells. The novelty and usefulness of perturbation centrality was validated in several other model, biological and social networks. The Turbine software and the perturbation centrality measure may provide a large variety of novel options to assess signaling, drug action, environmental and social interventions. PMID:24205090

  14. GRB Jets with Time Variable Central Engines

    NASA Astrophysics Data System (ADS)

    Morsony, Brian J.; Lazzati, D.; Begelman, M. C.

    2009-01-01

    We study the long-term evolution of relativistic jets in collapsars and examine the effects of time variable energy input on the subsequent gamma ray bursts. We carry out a series of high-resolution simulations of a jet propagating through a stellar envelope in 2D cylindrical coordinates using the FLASH relativistic hydrodynamics module. We carry out a series of simulations of central engines that vary on long time periods, comparable to the breakout time of the jet, short time periods (0.1s) much less than the breakout time, and that decay as a powerlaw at late times. Long period simulations show the opening angle of the jet rapidly adjusts to changes in input energy, in about 0.1s. For short period variability, the structure of the jet is not significantly effected by changes of the central engine output, but the signature of these changes is clearly visible in the energy flux seen by an observer. Short period changes are preserved from the central engine to well outside the star, indicating that short timescale fluctuation seen in prompt GRB emission can be due to central engine activity and will reflect the history of that activity. Models with a decaying energy input have a constant opening angle at late times. This is significant because it allows energy to escape from the central engine to a large radius even with a small energy input at late times, indicating that the central engine could be responsible for the shallow decay seen in X-ray afterglow lightcurves and for X-ray flares. A simulation of a flare from the central engine during the decay phase produces a flare of energy with a sharp rise and decay that is not significantly modified by passing through the stellar envelope.

  15. Microsurgical anatomy of the central lobe.

    PubMed

    Frigeri, Thomas; Paglioli, Eliseu; de Oliveira, Evandro; Rhoton, Albert L

    2015-03-01

    The central lobe consists of the pre- and postcentral gyri on the lateral surface and the paracentral lobule on the medial surface and corresponds to the sensorimotor cortex. The objective of the present study was to define the neural features, craniometric relationships, arterial supply, and venous drainage of the central lobe. Cadaveric hemispheres dissected using microsurgical techniques provided the material for this study. The coronal suture is closer to the precentral gyrus and central sulcus at its lower rather than at its upper end, but they are closest at a point near where the superior temporal line crosses the coronal suture. The arterial supply of the lower two-thirds of the lateral surface of the central lobe was from the central, precentral, and anterior parietal branches that arose predominantly from the superior trunk of the middle cerebral artery. The medial surface and the superior third of the lateral surface were supplied by the posterior interior frontal, paracentral, and superior parietal branches of the pericallosal and callosomarginal arteries. The venous drainage of the superior two-thirds of the lateral surface and the central lobe on the medial surface was predominantly through the superior sagittal sinus, and the inferior third of the lateral surface was predominantly through the superficial sylvian veins to the sphenoparietal sinus or the vein of Labbé to the transverse sinus. The pre- and postcentral gyri and paracentral lobule have a morphological and functional anatomy that differentiates them from the remainder of their respective lobes and are considered by many as a single lobe. An understanding of the anatomical relationships of the central lobe can be useful in preoperative planning and in establishing reliable intraoperative landmarks.

  16. Performance and Capacity of Centralized and Distributed Online Catalogs: Part 1--Centralized Online Catalogs.

    ERIC Educational Resources Information Center

    Epstein, Hank

    1986-01-01

    Discusses the importance of the response time of an online public catalog and its capacity to support multiple users without system degradation; outlines general requirements of an online catalog; explains the difference between menu and command systems; defines response time; and suggests ways of testing an online system accurately. (EM)

  17. Central retinal vessel blood flow after surgical treatment for central retinal vein occlusion.

    PubMed

    Crama, Niels; Gualino, Vincent; Restori, Marie; Charteris, David G

    2010-01-01

    The purpose of this study was to determine the effect of radial optic neurotomy and retinal endovascular surgery on retinal blood flow velocity in patients with central retinal vein occlusion. A prospective interventional case series. Six patients with a central retinal vein occlusion of <12 months' duration were included. Three patients were treated with radial optic neurotomy and three with retinal endovascular surgery. Five patients had decreased central venous blood flow velocity compared with the fellow eye, and one patient had similar central venous blood flow in both eyes at baseline. All study eyes had decreased central venous blood flow velocity compared with the fellow eye at 24 weeks after treatment. Two patients had a further decrease in central venous blood flow during the study. Three patients had no minimal change in central venous blood flow, and 1 patient showed a minimal increase from 3 cm/s at baseline to 4 cm/s 24 weeks after surgery. Radial optic neurotomy and retinal endovascular surgery do not alter central retinal blood flow velocity. The place of these therapies in the treatment for central retinal vein occlusion should be questioned.

  18. 21 CFR 1305.24 - Central processing of orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... or more registered locations and maintains a central processing computer system in which orders are... order with all linked records on the central computer system. (b) A company that has central processing... the company owns and operates....

  19. The Post-LBV Supernova 2001em

    NASA Astrophysics Data System (ADS)

    Van Dyk, Schuyler D.; Chornock, R.; Filippenko, A. V.; Foley, R. J.; Lewin, W. H. G.; Li, W.; Panagia, N.; Pooley, D.; Stockdale, C. J.; Weiler, K. W.

    2009-12-01

    The supernova (SN) 2001em in UGC 11794 was classified early as Type Ib/c, i.e., as one arising from a hydrogen-stripped star. As part of a radio survey with the Very Large Array of SNe Ib/c at late times (Stockdale et al. 2003, BAAS, 35, 1346), SN 2001em was detected as a highly luminous radio source ˜2 years after explosion. The SN was also subsequently discovered with Chandra to be a very luminous X-ray source. The properties of both the radio and X-ray emission are more characteristic of the Type II-narrow (IIn) SNe, where the SN shock is interacting with dense, massive circumstellar matter, resulting in bright radio synchrotron emission and thermal bremsstrahlung from the interaction region. In fact, SN 2001em has shown to have spectroscopically transformed to a SN IIn. The premise that this might indicate an off-axis gamma-ray burst has been presented (Granot & Ramirez-Ruiz 2004, ApJ, 609, L9) and later, rather convincingly, refuted (e.g., Schinzel et al. 2009, ApJ, 691, 1380). Chugai & Chevalier (2006, ApJ, 641, 1051) have interpreted the spectral transformation and radio/X-ray emission as the SN shock overtaking the detached hydrogen envelope of the progenitor star, which was shed in a superwind episode many years prior to explosion. Chevalier (2007, RMxAC, 30, 41) has further pointed to the required mass-loss rate in the event being equivalent to what would occur in the eruption of a luminous blue variable (LBV). The optical (ground-based and HST) and radio/X-ray data, together with mid-infrared Spitzer observations, tend to support this scenario of a very massive star that experienced a powerful LBV outburst prior to explosion. Such an event may not be unique, with possible parallels in the cases of SNe 2005bf and 2006jc, and may provide valuable new information about massive stellar evolution.

  20. Rotação do jato em DG tau próximo à região de sua formação: análise comparativa das velocidades radiais simuladas e observadas

    NASA Astrophysics Data System (ADS)

    Cerqueira, A. H.; de Gouveia dal Pino, E. M.

    2003-08-01

    Os modelos magneto-centrífugos utilizados para explicar a formação dos jatos Herbig-Haro assumem a presença de um disco de acresção em rotação kepleriana na base de lançamento do jato. Neste cenário, o jato transmite a informação da rotação do disco para regiões distantes da fonte central, além da superfície de Alfvén, na região de colimação inicial do jato. Recentemente, Bacciotti et al. (2002, ApJ, 537, L49) obtiveram pela primeira vez uma evidência observacional de rotação em um jato HH, o jato em DG Tau, em regiões próximas da fonte central, compatível (qualitativa e quantitativamente) com o esperado a partir dos modelos magneto-centrífugos para a produção e colimação inicial de jatos HH. No presente trabalho, apresentamos mapas de velocidade radial, obtidos através de simulações numéricas tri-dimensionais SPH, para um jato com características semelhantes ao jato em DG Tau, objetivando uma comparação com os mapas de velocidade radiais obtidos por Bacciotti et al.. Nossos resultados, embora preliminares, indicam que a inclusão de efeitos como a precessão, evidenciada em DG Tau (Dougados et al. 2000, A&A, 357, L61) devem ser levadas em consideração na análise da presença de rotação não só em DG Tau mas em qualquer sistema, com o uso das velocidades radias observadas. A ausência de um grau elevado de simetria axial (quebrada, por exemplo, pela precessão do eixo do jato; ou pela presença de uma superfície interna de trabalho, ou seja, um bow shock interno), implica também em uma maior complexidade nos mapas, com conseqüências relevantes para suas interpretações.

  1. New constraints on the cooling of the central compact object in CAS A

    SciTech Connect

    Posselt, B.; Pavlov, G. G.; Suleimanov, V.; Kargaltsev, O.

    2013-12-20

    To examine the previously claimed fast cooling of the Central Compact Object (CCO) in the Cas A supernova remnant (SNR), we analyzed two Chandra observations of this CCO, taken in a setup minimizing instrumental spectral distortions. We fit the two CCO X-ray spectra from 2006 and 2012 with hydrogen and carbon neutron star atmosphere models. The temperature and flux changes in the 5.5 yr between the two epochs depend on the adopted constraints on the fitting parameters and the uncertainties of the effective area calibrations. If we allow a change of the equivalent emitting region size, R {sub Em}, the effective temperature remains essentially the same. If R {sub Em} is held constant, the best-fit temperature change is negative, but its statistical significance ranges from 0.8σ to 2.5σ, depending on the model. If we assume that the optical depth of the ACIS filter contaminant in 2012 was ±10% different from its default calibration value, the significance of the temperature drop becomes 0.8σ-3.1σ, for the carbon atmospheres with constant R {sub Em}. Thus, we do not see a statistically significant temperature drop in our data, but the involved uncertainties are too large to firmly exclude the previously reported fast cooling. Our analysis indicate a decrease of 4%-6% (1.9σ-2.9σ significance) for the absorbed flux in the energy range 0.6-6 keV between 2006 and 2012, most prominent in the ≈1.4-1.8 keV energy range. It could be caused by unaccounted changes of the detector response or contributions from unresolved SNR material along the line of sight to the CCO.

  2. Central depression of nuclear charge density distribution

    SciTech Connect

    Chu Yanyun; Ren Zhongzhou; Wang Zaijun; Dong Tiekuang

    2010-08-15

    The center-depressed nuclear charge distributions are investigated with the parametrized distribution and the relativistic mean-field theory, and their corresponding charge form factors are worked out with the phase shift analysis method. The central depression of nuclear charge distribution of {sup 46}Ar and {sup 44}S is supported by the relativistic mean-field calculation. According to the calculation, the valence protons in {sup 46}Ar and {sup 44}S prefer to occupy the 1d{sub 3/2} state rather than the 2s{sub 1/2} state, which is different from that in the less neutron-rich argon and sulfur isotopes. As a result, the central proton densities of {sup 46}Ar and {sup 44}S are highly depressed, and so are their central charge densities. The charge form factors of some argon and sulfur isotopes are presented, and the minima of the charge form factors shift upward and inward when the central nuclear charge distributions are more depressed. Besides, the effect of the central depression on the charge form factors is studied with a parametrized distribution, when the root-mean-square charge radii remain constant.

  3. Geometry of complex networks and topological centrality

    NASA Astrophysics Data System (ADS)

    Ranjan, Gyan; Zhang, Zhi-Li

    2013-09-01

    We explore the geometry of complex networks in terms of an n-dimensional Euclidean embedding represented by the Moore-Penrose pseudo-inverse of the graph Laplacian (L). The squared distance of a node i to the origin in this n-dimensional space (lii+), yields a topological centrality index, defined as C∗(i)=1/lii+. In turn, the sum of reciprocals of individual node centralities, ∑i1/C∗(i)=∑ilii+, or the trace of L, yields the well-known Kirchhoff index (K), an overall structural descriptor for the network. To put into context this geometric definition of centrality, we provide alternative interpretations of the proposed indices that connect them to meaningful topological characteristics - first, as forced detour overheads and frequency of recurrences in random walks that has an interesting analogy to voltage distributions in the equivalent electrical network; and then as the average connectedness of i in all the bi-partitions of the graph. These interpretations respectively help establish the topological centrality (C∗(i)) of node i as a measure of its overall position as well as its overall connectedness in the network; thus reflecting the robustness of i to random multiple edge failures. Through empirical evaluations using synthetic and real world networks, we demonstrate how the topological centrality is better able to distinguish nodes in terms of their structural roles in the network and, along with Kirchhoff index, is appropriately sensitive to perturbations/re-wirings in the network.

  4. Central Venous Occlusion in the Hemodialysis Patient.

    PubMed

    Krishna, Vinay Narasimha; Eason, Joseph B; Allon, Michael

    2016-11-01

    Central venous stenosis (CVS) is encountered frequently among hemodialysis patients. Prior ipsilateral central venous catheterization and cardiac rhythm device insertions are common risk factors, but CVS can also occur in the absence of this history. Chronic CVS can cause thrombosis with partial or complete occlusion of the central vein at the site of stenosis. CVS is frequently asymptomatic and identified as an incidental finding during imaging studies. Symptomatic CVS presents most commonly as an upper- or lower-extremity edema ipsilateral to the CVS. Previously unsuspected CVS may become symptomatic after placement of an ipsilateral vascular access. The likelihood of symptomatic CVS may be affected by the central venous catheter (CVC) location; CVC side; duration of CVC dependence; type, location, and blood flow of the ipsilateral access; and extent of collateral veins. Venous angiography is the gold standard for diagnosis. Percutaneous transluminal angioplasty and stent placement can improve the stenosis and alleviate symptoms, but CVS typically recurs frequently, requiring repeated interventions. Refractory symptomatic CVS may require ligation of the ipsilateral vascular access. Because no available treatment option is curative, the goal should be to prevent CVS by minimizing catheters and central vein instrumentation in patients with chronic kidney disease and dialysis patients. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  5. Central nervous system complications after liver transplantation.

    PubMed

    Kim, Jeong-Min; Jung, Keun-Hwa; Lee, Soon-Tae; Chu, Kon; Roh, Jae-Kyu

    2015-08-01

    We investigated the diversity of central nervous system complications after liver transplantation in terms of clinical manifestations and temporal course. Liver transplantation is a lifesaving option for end stage liver disease patients but post-transplantation neurologic complications can hamper recovery. Between 1 January 2001 and 31 December 2010, patients who had undergone liver transplantation at a single tertiary university hospital were included. We reviewed their medical records and brain imaging data and classified central nervous system complications into four categories including vascular, metabolic, infectious and neoplastic. The onset of central nervous system complications was grouped into five post-transplantation intervals including acute (within 1 month), early subacute (1-3 months), late subacute (3-12 months), chronic (1-3 years), and long-term (after 3 years). During follow-up, 65 of 791 patients (8.2%) experienced central nervous system complications, with 30 occurring within 1 month after transplantation. Vascular etiology was the most common (27 patients; 41.5%), followed by metabolic (23; 35.4%), infectious (nine patients; 13.8%), and neoplastic (six patients). Metabolic encephalopathy with altered consciousness was the most common etiology during the acute period, followed by vascular disorders. An initial focal neurologic deficit was detected in vascular and neoplastic complications, whereas metabolic and infectious etiologies presented with non-focal symptoms. Our study shows that the etiology of central nervous system complications after liver transplantation changes over time, and initial symptoms can help to predict etiology.

  6. Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.

    PubMed

    Joseph, Agnel Praveen; Malhotra, Sony; Burnley, Tom; Wood, Chris; Clare, Daniel K; Winn, Martyn; Topf, Maya

    2016-05-01

    As the resolutions of Three Dimensional Electron Microscopic reconstructions of biological macromolecules are being improved, there is a need for better fitting and refinement methods at high resolutions and robust approaches for model assessment. Flex-EM/MODELLER has been used for flexible fitting of atomic models in intermediate-to-low resolution density maps of different biological systems. Here, we demonstrate the suitability of the method to successfully refine structures at higher resolutions (2.5-4.5Å) using both simulated and experimental data, including a newly processed map of Apo-GroEL. A hierarchical refinement protocol was adopted where the rigid body definitions are relaxed and atom displacement steps are reduced progressively at successive stages of refinement. For the assessment of local fit, we used the SMOC (segment-based Manders' overlap coefficient) score, while the model quality was checked using the Qmean score. Comparison of SMOC profiles at different stages of refinement helped in detecting regions that are poorly fitted. We also show how initial model errors can have significant impact on the goodness-of-fit. Finally, we discuss the implementation of Flex-EM in the CCP-EM software suite. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment

    PubMed Central

    Joseph, Agnel Praveen; Malhotra, Sony; Burnley, Tom; Wood, Chris; Clare, Daniel K.; Winn, Martyn; Topf, Maya

    2016-01-01

    As the resolutions of Three Dimensional Electron Microscopic reconstructions of biological macromolecules are being improved, there is a need for better fitting and refinement methods at high resolutions and robust approaches for model assessment. Flex-EM/MODELLER has been used for flexible fitting of atomic models in intermediate-to-low resolution density maps of different biological systems. Here, we demonstrate the suitability of the method to successfully refine structures at higher resolutions (2.5–4.5 Å) using both simulated and experimental data, including a newly processed map of Apo-GroEL. A hierarchical refinement protocol was adopted where the rigid body definitions are relaxed and atom displacement steps are reduced progressively at successive stages of refinement. For the assessment of local fit, we used the SMOC (segment-based Manders’ overlap coefficient) score, while the model quality was checked using the Qmean score. Comparison of SMOC profiles at different stages of refinement helped in detecting regions that are poorly fitted. We also show how initial model errors can have significant impact on the goodness-of-fit. Finally, we discuss the implementation of Flex-EM in the CCP-EM software suite. PMID:26988127

  8. 1. EXTERIOR OF CENTRAL HEATING STATION, BUILDING 102, LOOKING NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EXTERIOR OF CENTRAL HEATING STATION, BUILDING 102, LOOKING NORTH. - Mill Valley Air Force Station, Central Heating Station, East Ridgecrest Boulevard, Mount Tamalpais, Mill Valley, Marin County, CA

  9. EMS incident management: emergency medical logistics.

    PubMed

    Maniscalco, P M; Christen, H T

    1999-01-01

    If you had to get x amount of supplies to point A or point B, or both, in 10 minutes, how would you do it? The answer lies in the following steps: 1. Develop a logistics plan. 2. Use emergency management as a partner agency for developing your logistics plan. 3. Implement a push logistics system by determining what supplies/medications and equipment are important. 4. Place mass casualty/disaster caches at key locations for rapid deployment. Have medication/fluid caches available at local hospitals. 5. Develop and implement command caches for key supervisors and managers. 6. Anticipate the logistics requirements of a terrorism/tactical violence event based on a community threat assessment. 7. Educate the public about preparing a BLS family disaster kit. 8. Test logistics capabilities at disaster exercises. 9. Budget for logistics needs. 10. Never underestimate the importance of logistics. When logistics support fails, the EMS system fails.

  10. Online EM with weight-based forgetting.

    PubMed

    Celaya, Enric; Agostini, Alejandro

    2015-05-01

    In the online version of the EM algorithm introduced by Sato and Ishii ( 2000 ), a time-dependent discount factor is introduced for forgetting the effect of the old estimated values obtained with an earlier, inaccurate estimator. In their approach, forgetting is uniformly applied to the estimators of each mixture component depending exclusively on time, irrespective of the weight attributed to each unit for the observed sample. This causes an excessive forgetting in the less frequently sampled regions. To address this problem, we propose a modification of the algorithm that involves a weight-dependent forgetting, different for each mixture component, in which old observations are forgotten according to the actual weight of the new samples used to replace older values. A comparison of the time-dependent versus the weight-dependent approach shows that the latter improves the accuracy of the approximation and exhibits much greater stability.

  11. DOE EM industry programs robotics development

    SciTech Connect

    Staubly, R.; Kothari, V.

    1997-12-01

    The Office of Science and Technology (OST) manages an aggressive program for RD&D, as well as testing and evaluation for the U.S. Department of Energy`s (DOE) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. OST has organized technology management activities along focus teams for each major problem area. There are currently five focus areas: decontamination and decommissioning, tanks, subsurface contaminants, mixed waste, and plutonium. In addition, OST is pursuing research and development (R&D) that cuts across these focus areas by having applications in two or more focus areas. Currently, there are three cross-cutting programs: the robotics technology development; characterization, monitoring, and sensor technologies; and efficient separations and processing.

  12. A Pediatric Application of the STRAC Regional Hospital Trauma Registry Database: Pediatric Trauma Deaths in South Central Texas During 2004-2013.

    PubMed

    Buehner, Michelle; Aden, Jay; Borgman, Mathew; Love, Preston; Wright, Brandi; Edwards, Mary

    2017-01-01

    The purpose of this study was to define the demographics of pediatric traumatic injuries and to understand the predictive value of injury type, prehospital, and emergency department (ED) data regarding the mortality of pediatric trauma patients (<14 years of age) in South Central Texas. We report a retrospective review of pediatric trauma patients presenting to Trauma Service Area P in South Central Texas during 2004-2013. The primary outcome was mortality; secondary outcomes were ventilator days, hospital days, and intensive care unit stay. Demographics, Abbreviated Injury Score (AIS) codes, ICD-9 codes, transport times, Emergency Medical Services (EMS) vital signs en route and on arrival to the emergency department (ED), and outcomes were evaluated. A total of 8004 traumatically injured children presented to EDs in South Central Texas during the study period; 4109 of these presented via EMS. Most patients were Hispanic and male. Distribution was even across age groups. Overall mortality was 2%, and the mortality of those arriving by EMS was 3.7%. Abnormal vital signs and Glasgow Coma Score upon presentation to both EMS and the ED were strongly associated with mortality. Increased Injury Severity Score, the need for transfusion in the ED, and increased maximal AIS were also strongly associated with mortality. African American race was associated with increased mortality, although transport time and age were not. Most injuries overall were caused by motor vehicle collisions; however, burns and falls were most common in infants. The most lethal injuries were caused by firearms (mostly seen in preteens) and assaults (mostly seen in infants). This analysis of injured children in Southwest Texas offers insight into areas of needed quality improvement in the trauma system and potential areas to focus prevention efforts.

  13. 2008 Groundwater Monitoring Report Central Nevada Test Area, Corrective Action Unit 443

    SciTech Connect

    2009-03-01

    This report presents the 2008 groundwater monitoring results collected by the U.S. Department of Energy (DOE) Office of Legacy Management (LM) for the Central Nevada Test Area (CNTA) Subsurface Corrective Action Unit (CAU) 443. Responsibility for the environmental site restoration of the CNTA was transferred from the DOE Office of Environmental Management (DOE-EM) to DOE-LM on October 1, 2006. The environmental restoration process and corrective action strategy for CAU 443 are conducted in accordance with the Federal Facility Agreement and Consent Order (FFACO 2005) entered into by DOE, the U.S. Department of Defense, and the State of Nevada. The corrective action strategy for the site includes proof-of-concept monitoring in support of site closure. This report summarizes investigation activities associated with CAU 443 that were conducted at the site during fiscal year 2008. This is the second groundwater monitoring report prepared by DOE-LM for the CNTA.

  14. Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub.

    PubMed

    Hong, Kyungah; Upton, Heather; Miracco, Edward J; Jiang, Jiansen; Zhou, Z Hong; Feigon, Juli; Collins, Kathleen

    2013-10-01

    The eukaryotic reverse transcriptase, telomerase, adds tandem telomeric repeats to chromosome ends to promote genome stability. The fully assembled telomerase holoenzyme contains a ribonucleoprotein (RNP) catalytic core and additional proteins that modulate the ability of the RNP catalytic core to elongate telomeres. Electron microscopy (EM) structures of Tetrahymena telomerase holoenzyme revealed a central location of the relatively uncharacterized p50 subunit. Here we have investigated the biochemical and structural basis for p50 function. We have shown that the p50-bound RNP catalytic core has a relatively low rate of tandem repeat synthesis but high processivity of repeat addition, indicative of high stability of enzyme-product interaction. The rate of tandem repeat synthesis is enhanced by p50-dependent recruitment of the holoenzyme single-stranded DNA binding subunit, Teb1. An N-terminal p50 domain is sufficient to stimulate tandem repeat synthesis and bridge the RNP catalytic core, Teb1, and the p75 subunit of the holoenzyme subcomplex p75/p19/p45. In cells, the N-terminal p50 domain assembles a complete holoenzyme that is functional for telomere maintenance, albeit at shortened telomere lengths. Also, in EM structures of holoenzymes, only the N-terminal domain of p50 is visible. Our findings provide new insights about subunit and domain interactions and functions within the Tetrahymena telomerase holoenzyme.

  15. Epidemiology of Emergency Medical Services (EMS) Utilization in Four Indian Emergency Departments.

    PubMed

    Wijesekera, Olindi; Reed, Amanda; Chastain, Parker S; Biggs, Shauna; Clark, Elizabeth G; Kole, Tamorish; Chakrapani, Anoop T; Ashish, Nandy; Rajhans, Prasad; Breaud, Alan H; Jacquet, Gabrielle A

    2016-12-01

    Introduction Without a universal Emergency Medical Services (EMS) system in India, data on the epidemiology of patients who utilize EMS are limited. This retrospective chart review aimed to quantify and describe the burden of disease and patient demographics of patients who arrived by EMS to four Indian emergency departments (EDs) in order to inform a national EMS curriculum.

  16. The fermilab central computing facility architectural model

    NASA Astrophysics Data System (ADS)

    Nicholls, J.

    1989-12-01

    The goal of the current Central Computing Upgrade at Fermilab is to create a computing enviroment that maximizes total productivity, particularly for high energy physics analysis. The Computing Department and the Next Computer Acquisition Committee decided upon a model which includes five components: an interactive front-end, a LargeScale Scientific Computer (LSSC, a mainframe computing engine), a microprocessor farm system, a file server, and workstations. With the exception of the file server, all segments of this model are currently in production: a VAX/VMS cluster interactive front-end, an Amdahl VM computing engine, ACP farms, and (primary) VMS workstations. This paper will discuss the implemetation of the Fermilab Central Computing Facility Architectural Model. Implications for Code Management in such a heterogeneous environment, including issues such as modularity and centrality, will be considered. Special emphasis will be placed on connectivity and communications between the front-end, LSSC, and workstations, as practiced at Fermilab.

  17. Diagnosis and management of central hypersomnias

    PubMed Central

    Susta, Marek

    2012-01-01

    Central hypersomnias are diseases manifested in excessive daytime sleepiness (EDS) not caused by disturbed nocturnal sleep or misaligned circadian rhythms. Central hypersomnias includes narcolepsy with and without cataplexy, recurrent hypersomnia, idiopathic hypersomnia, with and without long sleep time, behaviorally induced insufficient sleep syndrome, hypersomnia and narcolepsy due to medical conditions, and finally hypersomnia induced by substance intake. The Epworth Sleepiness Scale is a subjective tool mostly used for EDS assessment, while the Multiple Sleep Latency Test serves as an objective diagnostic method for narcolepsy and idiopathic hypersomnias. As for symptomatic therapy of EDS, the central nervous system stimulants modafinil and methylphenidate seem to work well in most cases and in narcolepsy and Parkinson’s disease; sodium oxybate also has notable therapeutic value. PMID:22973425

  18. Effect of sound deprivation on central hearing.

    PubMed

    Welsh, L W; Welsh, J J; Healy, M P

    1983-12-01

    The authors have investigated the thesis that intermittent hearing impairment due to middle ear disease in the early years of life results in a central auditory disturbance which may persist in adulthood. The concept that, during the speech development years, auditory disturbances interfere with the normal maturation of central auditory processing appear to be clearly established. Thirty-five children, free of active ear disease and normally hearing by standard peripheral audiometry, are the basis for the study. The monotic tests employing temporal and frequency distortion and the dichotic challenges of competing stimuli and central integration provide the test data. Approximately 75% of the study group fail at least 1 segment of the battery, beyond 2 standard deviations from the normal data. A decreasing percentage of the study group exceed the normative values in 2 or more of the test components. In view of these data on aggressive program of auditory conservation is suggested during the early years of life.

  19. Dry needling - peripheral and central considerations.

    PubMed

    Dommerholt, Jan

    2011-11-01

    Dry needling is a common treatment technique in orthopedic manual physical therapy. Although various dry needling approaches exist, the more common and best supported approach targets myofascial trigger points. This article aims to place trigger point dry needling within the context of pain sciences. From a pain science perspective, trigger points are constant sources of peripheral nociceptive input leading to peripheral and central sensitization. Dry needling cannot only reverse some aspects of central sensitization, it reduces local and referred pain, improves range of motion and muscle activation pattern, and alters the chemical environment of trigger points. Trigger point dry needling should be based on a thorough understanding of the scientific background of trigger points, the differences and similarities between active and latent trigger points, motor adaptation, and central sensitize application. Several outcome studies are included, as well as comments on dry needling and acupuncture.

  20. Late Quaternary Eolian Deposition in Central Italy

    NASA Astrophysics Data System (ADS)

    Narcisi, Biancamaria

    2000-09-01

    Records of eolian quartz from two continuous sediment sequences drilled in Lagaccione and Lago di Vico volcanic lakes in central Italy contribute to the knowledge of eolian deposition in the central Mediterranean during the last 100,000 years. The chronology is based on 14C and 40Ar/39Ar dating and tephra analysis. Pollen data provide the paleoenvironmental framework and enable correlation between the cores. Eolian inputs were high during the steppe phases corresponding to oxygen isotope stages 4 and 2. Low inputs correspond to the forest phases of the last interglacial and the middle Holocene. Eolian inputs have increased in the late Holocene. Patterns of eolian deposition in central Italy resemble the Antarctic dust record from the Vostok ice core. The Italian patterns may also correspond with hydrological changes registered in North Africa. The main source of dust loading over the Mediterranean now, North Africa, may have played an important role in dust supply throughout the last climatic cycle.

  1. A magnetotelluric profile across Central Java, Indonesia

    NASA Astrophysics Data System (ADS)

    Ritter, O.; Hoffmann-Rothe, A.; Müller, A.; Dwipa, S.; Arsadi, E. M.; Mahfi, A.; Nurnusanto, I.; Byrdina, S.; Echternacht, F.; Haak, V.

    1998-12-01

    Along a N30°E striking profile in central Java, Indonesia we recorded broadband magnetotelluric data at 8 sites in the period range 0.01 s-10000s. A preliminary analysis of apparent resistivity, phase and magnetic transfer function data favours a one-dimensional interpretation of most sites for the upper 3-5 km of the crust and a two- or three- dimensional structure for the lower crust. Several conductive features can be distinguished: (i) a strong “ocean effect” at the southern most site, (ii) a zone of very high conductivity in the central part of the profile, and (iii) a conductor in the north that cannot be caused by the shallow Java sea. We discuss tentatively causes for these anomalies. The conductor in the central part of the profile is probably connected with volcanic or geothermal activity, while the anomaly in the north could be an expression of processes associated with an active fault zone.

  2. Impacted primary mandibular central incisors: case report.

    PubMed

    Darwish, Salwa M; Salama, Fouad S

    2002-01-01

    Impaction of primary teeth is very rare especially in the maxillary anterior teeth. A tooth that fails to erupt into a normal functional position by the time it normally should, is considered impacted. The purpose of this article is to present a case of a 2 year and 4-month-old male with an impacted primary mandibular central incisors. Clinical examination did not reveal systemic diseases or trauma in the facial region. Clinical and radiographic examinations are described. Treatment consisted of a period of observation for 6 months and the extraction of the impacted primary mandibular central incisors. Eight months after the surgery, the permanent central incisors were erupted in the proper position.

  3. Central venous obstruction in the thorax.

    PubMed

    Collin, G; Jones, R G; Willis, A P

    2015-06-01

    Central venous stenosis and occlusion can occur secondary to a spectrum of conditions ranging from aggressive malignancy to benign extrinsic anatomical compression in otherwise healthy individuals. Irrespective of aetiology, significant morbidity in the acute setting and long term can occur unless prompt accurate diagnosis and appropriate management is initiated, the radiologist being central to both. The present review will provide radiologists with a thorough illustration and explanation of the range of central venous conditions in the thorax (including deep vein thrombosis, thoracic outlet syndrome, haemodialysis, and malignancy related causes), the salient imaging findings and interventional management using case examples from the authors' practice. Copyright © 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  4. Hydrogels for central nervous system therapeutic strategies.

    PubMed

    Russo, Teresa; Tunesi, Marta; Giordano, Carmen; Gloria, Antonio; Ambrosio, Luigi

    2015-12-01

    The central nervous system shows a limited regenerative capacity, and injuries or diseases, such as those in the spinal, brain and retina, are a great problem since current therapies seem to be unable to achieve good results in terms of significant functional recovery. Different promising therapies have been suggested, the aim being to restore at least some of the lost functions. The current review deals with the use of hydrogels in developing advanced devices for central nervous system therapeutic strategies. Several approaches, involving cell-based therapy, delivery of bioactive molecules and nanoparticle-based drug delivery, will be first reviewed. Finally, some examples of injectable hydrogels for the delivery of bioactive molecules in central nervous system will be reported, and the key features as well as the basic principles in designing multifunctional devices will be described.

  5. Dry needling — peripheral and central considerations

    PubMed Central

    Dommerholt, Jan

    2011-01-01

    Dry needling is a common treatment technique in orthopedic manual physical therapy. Although various dry needling approaches exist, the more common and best supported approach targets myofascial trigger points. This article aims to place trigger point dry needling within the context of pain sciences. From a pain science perspective, trigger points are constant sources of peripheral nociceptive input leading to peripheral and central sensitization. Dry needling cannot only reverse some aspects of central sensitization, it reduces local and referred pain, improves range of motion and muscle activation pattern, and alters the chemical environment of trigger points. Trigger point dry needling should be based on a thorough understanding of the scientific background of trigger points, the differences and similarities between active and latent trigger points, motor adaptation, and central sensitize application. Several outcome studies are included, as well as comments on dry needling and acupuncture. PMID:23115475

  6. Best Practices for Managing Large CryoEM Facilities

    PubMed Central

    Alewijnse, Bart; Ashton, Alun W.; Chambers, Melissa G.; Chen, Songye; Cheng, Anchi; Ebrahim, Mark; Eng, Edward; Hagen, Wim J. H.; Koster, Abraham J.; López, Claudia S.; Lukoyanova, Natalya; Ortega, Joaquin; Renault, Ludovic; Reyntjens, Steve; Rice, William J.; Scapin, Giovanna; Schrijver, Raymond; Siebert, Alistair; Stagg, Scott M.; Grum-Tokars, Valerie; Wright, Elizabeth R.; Wu, Shenping; Yu, Zhiheng; Zhou, Z. Hong; Carragher, Bridget; Potter, Clinton S.

    2017-01-01

    This paper provides an overview of the discussion and presentations from the Workshop on the Management of Large CryoEM Facilities held at the New York Structural Biology Center, New York, NY on February 6–7, 2017. A major objective of the workshop was to discuss best practices for managing cryoEM facilities. The discussions were largely focused on supporting single-particle methods for cryoEM and topics included: user access, assessing projects, workflow, sample handling, microscopy, data management and processing, and user training. PMID:28827185

  7. Thrombolytic therapy for central venous catheter occlusion

    PubMed Central

    Baskin, Jacquelyn L.; Reiss, Ulrike; Wilimas, Judith A.; Metzger, Monika L.; Ribeiro, Raul C.; Pui, Ching-Hon; Howard, Scott C.

    2012-01-01

    Background Long-term central venous catheters have improved the quality of care for patients with chronic illnesses, but are complicated by obstructions which can result in delay of treatment or catheter removal. Design and Methods This paper reviews thrombolytic treatment for catheter obstruction. Literature from Medline searches using the terms “central venous catheter”, “central venous access device” OR “central venous line” associated with the terms “obstruction”, “occlusion” OR “thrombolytic” was reviewed. Efficacy of thrombolytic therapy, central venous catheter clearance rates and time to clearance were assessed. Results Alteplase, one of the current therapies, clears 52% of obstructed catheters within 30 min with 86% overall clearance (after 2 doses, when necessary). However, newer medications may have higher efficacy or shorter time to clearance. Reteplase cleared 67–74% within 30–40 min and 95% of catheters overall. Occlusions were resolved in 70 and 83% of patients with one and 2 doses of tenecteplase, respectively. Recombinant urokinase cleared 60% of catheters at 30 min and 73% overall. Alfimeprase demonstrated rapid catheter clearance with resolution in 40% of subjects within 5 min, 60% within 30 min, and 80% within 2 h. Additionally, urokinase prophylaxis decreased the incidence of catheter occlusions from 16–68% in the control group to 4–23% in the treatment group; in some studies, rates of catheter infections were also decreased in the urokinase group. Conclusions Thrombolytic agents successfully clear central venous catheter occlusions in most cases. Newer agents may act more rapidly and effectively than currently utilized therapies, but randomized studies with direct comparisons of these agents are needed to determine optimal management for catheter obstruction. PMID:22180420

  8. HANFORD SITE CENTRAL PLATEAU CLEANUP COMPLETION STRATEGY

    SciTech Connect

    BERGMAN TB

    2011-01-14

    Cleanup of the Hanford Site is a complex and challenging undertaking. The U.S. Department of Energy (DOE) has developed a comprehensive vision for completing Hanford's cleanup mission including transition to post-cleanup activities. This vision includes 3 principle components of cleanup: the {approx}200 square miles ofland adjacent to the Columbia River, known as the River Corridor; the 75 square miles of land in the center of the Hanford Site, where the majority of the reprocessing and waste management activities have occurred, known as the Central Plateau; and the stored reprocessing wastes in the Central Plateau, the Tank Wastes. Cleanup of the River Corridor is well underway and is progressing towards completion of most cleanup actions by 2015. Tank waste cleanup is progressing on a longer schedule due to the complexity of the mission, with construction of the largest nuclear construction project in the United States, the Waste Treatment Plant, over 50% complete. With the progress on the River Corridor and Tank Waste, it is time to place increased emphasis on moving forward with cleanup of the Central Plateau. Cleanup of the Hanford Site has been proceeding under a framework defmed in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement). In early 2009, the DOE, the State of Washington Department of Ecology, and the U.S. Environmental Protection Agency signed an Agreement in Principle in which the parties recognized the need to develop a more comprehensive strategy for cleanup of the Central Plateau. DOE agreed to develop a Central Plateau Cleanup Completion Strategy as a starting point for discussions. This DOE Strategy was the basis for negotiations between the Parties, discussions with the State of Oregon, the Hanford Advisory Board, and other Stakeholder groups (including open public meetings), and consultation with the Tribal Nations. The change packages to incorporate the Central Plateau Cleanup Completion Strategy were signed by

  9. A Retrospective Review of Treatment Results for Patients With Central Centrifugal Cicatrical Alopecia.

    PubMed

    Eginli, Ariana; Dothard, Emily; Bagayoko, Courtney W; Huang, Karen; Daniel, Alyssa; McMichael, Amy J

    2017-04-01

    INTRODUCTION: Central centrifugal cicatricial alopecia (CCCA) is a form of scarring alopecia primarily affecting women of African descent on the crown of the scalp. Limited data exists regarding evidence-based treatment for CCCA.

    OBJECTIVE: To examine photos of subjects with CCCA before and after treatment in order to evaluate results of treatment and compare results of different treatment regimens.

    METHODS: Photographs of 15 subjects with CCCA before and after treatment were evaluated by two blinded investigators who assigned disease severity scores to photographs based on a published scale: Central Scalp Alopecia Photographic Scale in African American Women.

    RESUTLS: Median change in severity score (post-treatment severity score - pre-treatment severity score) was 0.5 (P = 0.58) for all 15 subjects receiving a series of 7 to 8 intralesional steroid injections along with topical steroids (Class I/II) +/- minoxidil and +/- anti-dandruff shampoo, indicating worsening of disease after treatment. Subjects receiving minoxidil versus those who did not (0.25 vs 0.5; P = 0.38) and subjects receiving anti-dandruff shampoo versus those who did not (0.0 vs 0.5; P = 0.42) demonstrated no statistically significant difference in pre- and post-treatment severity scores. Of 15 subjects, 5/15 (33.3%) had decreased severity scores, 8/15 (53.3%) had increased severity scores, and 2/15 (13.3%) had no change in severity scores.

    CONCLUSIONS: Although no statistically significant difference was found in pre- versus post-treatment disease severity, this may indicate intralesional steroid injections and topical steroids +/- minoxidil and +/- anti-dandruff shampoo halt disease progression.

    <em>J Drugs Dermatol. 2017;16(4):317-320.em>

    .

  10. 75 FR 14436 - Ameren Corporation, Illinois Power Company, Central Illinois Light Company, Central Illinois...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Energy Regulatory Commission Ameren Corporation, Illinois Power Company, Central Illinois Light Company, Central Illinois Public Service Company, Ameren Energy Resources Company, LLC, AmerenEnergy Resources Generating Company; Notice of Filing March 18, 2010. Take notice that on March 15, 2010, Ameren...

  11. Agreement Between Central Michigan University and Central Michigan University District of Michigan Association of Higher Education.

    ERIC Educational Resources Information Center

    Central Michigan Univ., Mount Pleasant.

    This document presents the agreement between the Central Michigan University (CMU) and Central Michigan University, District of Michigan Association of Higher Education. The agreement covers the purpose and intent, recognition, aid to other collective bargaining agents, deduction of district dues and initiation fees, special conferences, grievance…

  12. District Central Office Leadership as Teaching: How Central Office Administrators Support Principals' Development as Instructional Leaders

    ERIC Educational Resources Information Center

    Honig, Meredith I.

    2012-01-01

    Purpose: Research on educational leadership underscores the importance of principals operating as instructional leaders and intensive job-embedded supports for such work; this research also identifies central office staff as key support providers. However, it teaches little about what central office staff do when they provide such support and how…

  13. What Can We Learn from 15,000 Teachers in Central Europe and Central Asia?

    ERIC Educational Resources Information Center

    Temple, Charles

    2000-01-01

    Describes the "Reading and Writing for Critical Thinking Project" which has now sent more than 70 volunteer teacher educators into 20 countries across Central Europe and Central Asia to help teachers to try out methods that foster active learning and critical thinking. Discusses support for the project, teaching strategies introduced,…

  14. District Central Office Leadership as Teaching: How Central Office Administrators Support Principals' Development as Instructional Leaders

    ERIC Educational Resources Information Center

    Honig, Meredith I.

    2012-01-01

    Purpose: Research on educational leadership underscores the importance of principals operating as instructional leaders and intensive job-embedded supports for such work; this research also identifies central office staff as key support providers. However, it teaches little about what central office staff do when they provide such support and how…

  15. What Can We Learn from 15,000 Teachers in Central Europe and Central Asia?

    ERIC Educational Resources Information Center

    Temple, Charles

    2000-01-01

    Describes the "Reading and Writing for Critical Thinking Project" which has now sent more than 70 volunteer teacher educators into 20 countries across Central Europe and Central Asia to help teachers to try out methods that foster active learning and critical thinking. Discusses support for the project, teaching strategies introduced,…

  16. Evidence-based measures to prevent central line-associated bloodstream infections: a systematic review.

    PubMed

    Perin, Daniele Cristina; Erdmann, Alacoque Lorenzini; Higashi, Giovana Dorneles Callegaro; Sasso, Grace Teresinha Marcon Dal

    2016-09-01

    to identify evidence-based care to prevent CLABSI among adult patients hospitalized in ICUs. systematic review conducted in the following databases: PubMed, Scopus, Cinahl, Web of Science, Lilacs, Bdenf and Cochrane Studies addressing care and maintenance of central venous catheters, published from January 2011 to July 2014 were searched. The 34 studies identified were organized in an instrument and assessed by using the classification provided by the Joanna Briggs Institute. the studies presented care bundles including elements such as hand hygiene and maximal barrier precautions; multidimensional programs and strategies such as impregnated catheters and bandages and the involvement of facilities in and commitment of staff to preventing infections. care bundles coupled with education and the commitment of both staff and institutions is a strategy that can contribute to decreased rates of central line-associated bloodstream infections among adult patients hospitalized in intensive care units. identificar evidências de cuidados para prevenção de infecção de corrente sanguínea relacionada a cateter venoso central em pacientes adultos em Unidades de Terapia Intensiva. revisão Sistemática realizada por meio de busca nas bases de dados Pubmed, Scopus, Cinahl, Web of Science, Lilacs, Bdenf e Cochrane. Foram buscadas pesquisas com cuidados com a cateterização e manutenção do cateter venoso central, publicados de janeiro de 2011 a julho de 2014. Os 34 estudos incluídos foram organizados em um instrumento e avaliados por meio da classificação do The Joanna Briggs Institute. os estudos apresentaram bundles de cuidados com elementos como a higiene das mãos e precauções máximas de barreira; programas multidimensionais e estratégias como cateteres e curativos impregnados e o envolvimento da instituição e engajamento da equipe nos esforços para prevenção de infecção. os cuidados no formato de bundles aliados com a educação e engajamento da equipe e

  17. Flash Flooding Events in South Central Texas.

    DTIC Science & Technology

    1982-08-01

    I AD-ALI 977 AIR FORCE INST OF TECH WRIGHT-PATTERSON AFa OH F/G 4/2 FLASH FLOODING EVENTS IN SOUTH CENTRAL TEXAS. CU) N AU 82 T W UTLEY UNCLASSIFIED...COVERED Flash Flooding Events in South Central Texas THESIS/ESeAMAN S. PERFORMING ORG. REPORI NUMBER 7. AUTHOR(*) S. CONTRACT OR GRANT NUMBER(s) Tom...and to flash flooding events which occurred in 1981 they proved to be excellent predi’ctors. When compared to the 1981 National Weather Service

  18. Hydrological climate change projections for Central America

    NASA Astrophysics Data System (ADS)

    Hidalgo, Hugo G.; Amador, Jorge A.; Alfaro, Eric J.; Quesada, Beatriz

    2013-07-01

    Runoff climate change projections for the 21st century were calculated from a suite of 30 General Circulation Model (GCM) simulations for the A1B emission scenario in a 0.5° × 0.5° grid over Central America. The GCM data were downscaled using a version of the Bias Correction and Spatial Downscaling (BCSD) method and then used in the Variable Infiltration Capacity (VIC) macroscale hydrological model. The VIC model showed calibration skill in Honduras, Nicaragua, Costa Rica and Panama, but the results for some of the northern countries (Guatemala, El Salvador and Belize) and for the Caribbean coast of Central America was not satisfactory. Bias correction showed to remove effectively the biases in the GCMs. Results of the projected climate in the 2050-2099 period showed median significant reductions in precipitation (as much as 5-10%) and runoff (as much as 10-30%) in northern Central America. Therefore in this sub-region the prevalence of severe drought may increase significantly in the future under this emissions scenario. Northern Central America could warm as much as 3 °C during 2050-2099 and southern Central America could reach increases as much as 4 °C during the same period. The projected dry pattern over Central America is consistent with a southward displacement of the Intertropical Convergence Zone (ITCZ). In addition, downscaling of the NCEP/NCAR Reanalysis data from 1948 to 2012 and posterior run in VIC, for two locations in the northern and southern sub-regions of Central America, suggested that the annual runoff has been decreasing since ca. 1980, which is consistent with the sign of the runoff changes of the GCM projections. However, the Reanalysis 1980-2012 drying trends are generally much stronger than the corresponding GCM trends. Among the possible reasons for that discrepancy are model deficiencies, amplification of the trends due to constructive interference with natural modes of variability in the Reanalysis data, errors in the Reanalysis

  19. Anatomic considerations for central venous cannulation

    PubMed Central

    Bannon, Michael P; Heller, Stephanie F; Rivera, Mariela

    2011-01-01

    Central venous cannulation is a commonly performed procedure which facilitates resuscitation, nutritional support, and long-term vascular access. Mechanical complications most often occur during insertion and are intimately related to the anatomic relationship of the central veins. Working knowledge of surface and deep anatomy minimizes complications. Use of surface anatomic landmarks to orient the deep course of cannulating needle tracts appropriately comprises the crux of complication avoidance. The authors describe use of surface landmarks to facilitate safe placement of internal jugular, subclavian, and femoral venous catheters. The role of real-time sonography as a safety-enhancing adjunct is reviewed. PMID:22312225

  20. Qualification testing for a central station

    NASA Technical Reports Server (NTRS)

    Forrester, D. L.

    1983-01-01

    Qualification testing for a Central Station Photovoltaic (PV) Facility depends to a great extent on the system design, (fixed versus tracking), and the level of data acquisition/control which is incorporated into the system. The basic elements which require qualification tests include: dc power production/collection; tracker conversion systems; ac utility interface; system level control; and data acquisition/reporting. The qualification tests from the Lungo (ARCO) 1 MW Facility which were completed in January 1983 are discussed. The philosophy and many of the procedures are applicable to any central station PV facility.

  1. Church Orientations in Central and Eastern Europe

    NASA Astrophysics Data System (ADS)

    Laužikas, Rimvydas

    The objective of this case study is to discuss church orientation in Central and Eastern Europe. Due to its geographical situation, this region is a specific part of European cultural space: it is remote from the main cultural centers, it was the last to adopt Christianity, and it experienced intensive interactions with Byzantine culture. Therefore, we can assess church orientation in Central and Eastern Europe as a tradition affected by multicultural interactions and in which there is an interlacement of Catholicism from Western Europe, Byzantinism, local pagan faiths and, in part, the ideas of conception of geographical space of the Jews, Karaites, and Muslims.

  2. Central Calorimeter Thermal Gradient Module Connection Analysis

    SciTech Connect

    Rudland, D.L.; /Fermilab

    1987-08-07

    Two 20 kW condensing and one 10 kW steady state cooling coils will be used to cool and condense gaseous argon in the Central Calorimeter (CC) Cryostat. Since this cool down (300K to 90K) will inevitably cause shrinkage in the modules contained inside the cryostat, the connections between the modules have to be designed to withstand the increase in forces and moments induced by this contraction. This paper presents finite element analysis (ANSYS{reg_sign}) results to aid in the design or modification of the Central Calorimeter module connections.

  3. Hemodialysis catheter-associated central venous stenosis.

    PubMed

    Yevzlin, Alexander S

    2008-01-01

    The purpose of this review is to explore the pathophysiology, epidemiology, and interventional treatment of central vein stenosis (CVS) that may result from central vein catheter (CVC) placement. The precise mechanism of CVC-associated CVS remains largely undefined, though anatomic considerations appear to play a prominent pathologic role. The impact of CVC-associated CVS on arteriovenous fistula outcomes is reviewed. The percutaneous treatment of CVS, observation, angioplasty, or angioplasty with stent placement is reviewed, along with potential surgical treatment options. As the treatment outcomes of CVC-associated CVS have been disappointing, catheter avoidance remains the best strategy.

  4. Central pattern generators and interphyletic awareness.

    PubMed

    Stein, P S

    1999-01-01

    Our understandings of how neuronal networks organized as central pattern generators generate motor behavior have greatly increased in the last 40 years. In the 60s, many investigators studying invertebrate motor behaviors were not aware of the work of those studying vertebrate motor behaviors, and vice versa. In the 70s, key conferences provided venues for important interactions among investigators working on preparations in different species. These interactions, termed interphyletic awareness, continued in the 80s and 90s at major conferences and played important roles in the development of our understandings of central pattern generators for motor behavior in these decades.

  5. Peripheral and central mechanisms of stress resilience

    PubMed Central

    Pfau, Madeline L.; Russo, Scott J.

    2014-01-01

    Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress. PMID:25506605

  6. On central-difference and upwind schemes

    NASA Technical Reports Server (NTRS)

    Swanson, R. C.; Turkel, Eli

    1990-01-01

    A class of numerical dissipation models for central-difference schemes constructed with second- and fourth-difference terms is considered. The notion of matrix dissipation associated with upwind schemes is used to establish improved shock capturing capability for these models. In addition, conditions are given that guarantee that such dissipation models produce a Total Variation Diminishing (TVD) scheme. Appropriate switches for this type of model to ensure satisfaction of the TVD property are presented. Significant improvements in the accuracy of a central-difference scheme are demonstrated by computing both inviscid and viscous transonic airfoil flows.

  7. Environmental Education and Development Division (EM-522). Annual report, Fiscal year 1993

    SciTech Connect

    Not Available

    1993-12-31

    The Environmental Education and Development Division (EM-522) is one of three divisions within the Office of Technology Integration and Environmental Education and Development (EM-52) in Environmental Restoration and Waste Management`s (EM`s) Office of Technology Development (EM-50). The primary design criterion for EM-522 education activities is directly related to meeting EM`s goal of environmental compliance on an accelerated basis and cleanup of the 1989 inventory of inactive sites and facilities by the year 2019. Therefore, EM-522`s efforts are directed specifically toward stimulating knowledge and capabilities to achieve the goals of EM while contributing to DOE`s overall goal of increasing scientific, mathematical, and technical literacy and competency. This report discusses fiscal year 1993 activities.

  8. Hydrology of Central Florida Lakes - A Primer

    USGS Publications Warehouse

    Schiffer, Donna M.

    1998-01-01

    INTRODUCTION Lakes are among the most valued natural resources of central Florida. The landscape of central Florida is riddled with lakeswhen viewed from the air, it almost seems there is more water than land. Florida has more naturally formed lakes than other southeastern States, where many lakes are created by building dams across streams. The abundance of lakes on the Florida peninsula is a result of the geology and geologic history of the State. An estimated 7,800 lakes in Florida are greater than 1 acre in surface area. Of these, 35 percent are located in just four counties (fig. 1): Lake, Orange, Osceola, and Polk (Hughes, 1974b). Lakes add to the aesthetic and commercial value of the area and are used by many residents and visitors for fishing, boating, swimming, and other types of outdoor recreation. Lakes also are used for other purposes such as irrigation, flood control, water supply, and navigation. Residents and visitors commonly ask questions such as Whyare there so many lakes here?, Why is my lake drying up (or flooding)?, or Is my lake spring-fed? These questions indicate that the basic hydrology of lakes and the interaction of lakes with ground water and surface water are not well understood by the general population. Because of the importance of lakes to residents of central Florida and the many questions and misconceptions about lakes, this primer was prepared by the U.S. Geological Survey (USGS) in cooperation with the St. Johns River Water Management District and the South Florida Water Management District. The USGS has been collecting hydrologic data in central Florida since the 1920s, obtaining valuable information that has been used to better understand the hydrology of the water resources of central Florida, including lakes. In addition to data collection, as of 1994, the USGS had published 66 reports and maps on central Florida lakes (Garcia and Hoy, 1995). The main purpose of this primer is to describe the hydrology of lakes in central

  9. Central and non-central networks, cognition, clinical symptoms, and polygenic risk scores in schizophrenia.

    PubMed

    Alloza, Clara; Bastin, Mark E; Cox, Simon R; Gibson, Jude; Duff, Barbara; Semple, Scott I; Whalley, Heather C; Lawrie, Stephen M

    2017-09-07

    Schizophrenia is a complex disorder that may be the result of aberrant connections between specific brain regions rather than focal brain abnormalities. Here, we investigate the relationships between brain structural connectivity as described by network analysis, intelligence, symptoms, and polygenic risk scores (PGRS) for schizophrenia in a group of patients with schizophrenia and a group of healthy controls. Recently, researchers have shown an interest in the role of high centrality networks in the disorder. However, the importance of non-central networks still remains unclear. Thus, we specifically examined network-averaged fractional anisotropy (mean edge weight) in central and non-central subnetworks. Connections with the highest betweenness centrality within the average network (>75% of centrality values) were selected to represent the central subnetwork. The remaining connections were assigned to the non-central subnetwork. Additionally, we calculated graph theory measures from the average network (connections that occur in at least 2/3 of participants). Density, strength, global efficiency, and clustering coefficient were significantly lower in patients compared with healthy controls for the average network (pFDR  < 0.05). All metrics across networks were significantly associated with intelligence (pFDR  < 0.05). There was a tendency towards significance for a correlation between intelligence and PGRS for schizophrenia (r = -0.508, p = 0.052) that was significantly mediated by central and non-central mean edge weight and every graph metric from the average network. These results are consistent with the hypothesis that intelligence deficits are associated with a genetic risk for schizophrenia, which is mediated via the disruption of distributed brain networks. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  10. Transforming EMS Compliance at the Utah National Guard with an Automated Tool

    DTIC Science & Technology

    2009-05-01

    14001 & EMS 16 ISO 14001 EMS Requirements ISO14001 Requirement Condition WebEMIS™ 4.1 General Requirements None Uploads and stores EO 13423, EO...top level management with metrics and performance measures based on media WebEMIS vs. ISO 14001 & EMS 17 ISO 14001 EMS Requirements ISO14001 ...14001 EMS Requirements ISO14001 Requirement Condition WebEMIS 4.4 Implementation and Operation 4.4.1 Resources, Roles, Responsibility and Authority

  11. Estimativas de possiveis recursos de petroleo e gas na America Central e na America do Sul [Estimates of possible petroleum and gas resources in Central American and South America

    USGS Publications Warehouse

    Schenk, C.S.

    2001-01-01

    O U.S. Geological Survey recentemente completou estimativas de possíveis recursos de petróleo e gás em 130 áreas petrolíferas pré-determinadas no mundo (USGS, 2000). Vinte e três destas áreas ficam na América do Sul, na América Central, e no Caribe (fig. 1). Os resultados estão apresentados na tabela 1. Nas 23 áreas, estimamos um total de 105 BBO e um total de 487 TCFG. A região composta de América Central mais América do Sul ficou em terceiro lugar no mundo em termos de possíveis recursos de petróleo e gás. No primeiro lugar ficou o Oriente Médio e no segundo lugar ficou a antiga União Soviética (USGS, 2000). As áreas com maiores probabilidades de encontrar depósitos gigantes de petróleo e gás se localizam nas áreas do Oceano Atlântico começando com a Bacia de Santos no sul até a Bacia Guyana-Suriname no norte. As possibilidades de existirem depósitos gigantes são maiores nas áreas submersas do mar até profundidades de 3,600 m. Diversos depósitos gigantes de petróleo foram descobertos no mar na Bacia de Campos e ainda podem serem encontrados depósitos similares na Bacia de Campos e suas imediações.

  12. Recent developments in the CCP-EM software suite

    PubMed Central

    Burnley, Tom

    2017-01-01

    As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting. The framework includes tools for project and data management. An overview of the design of the framework is given, together with a survey of the functionality at different levels. The current CCP-EM suite has particular strength in the building and refinement of atomic models into cryo-EM reconstructions, which is described in detail. PMID:28580908

  13. E.M. and Hadronic Shower Simulation with FLUKA

    SciTech Connect

    Battistoni, G.; Fasso, A.; Ferrari, A.; Ranft, J.; Rubbia, A.; Sala, P.R.; /INFN, Milan /SLAC /CERN /Siegen U. /Zurich, ETH

    2005-10-03

    A description of the main features of e.m. and hadronic shower simulation models used in the FLUKA code is summarized and some recent applications are discussed. The general status of the FLUKA project is also reported.

  14. Recent developments in the CCP-EM software suite.

    PubMed

    Burnley, Tom; Palmer, Colin M; Winn, Martyn

    2017-06-01

    As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting. The framework includes tools for project and data management. An overview of the design of the framework is given, together with a survey of the functionality at different levels. The current CCP-EM suite has particular strength in the building and refinement of atomic models into cryo-EM reconstructions, which is described in detail.

  15. DOE-EM Science of Safety Robotics Challenge

    SciTech Connect

    Rimando, Rodrigo; Watts, Alex; Bobbitt, John; McLaughlin, Doug; Quigley, Morgan; Gladwell, Scott; McLoughlin, Mike; Kinnamon, Tony; Garcia, Joe; Ansari, Alex; Voyles, Richard; Chambers, David; Pryor, Mitch; Workman, Theresa; Mehling, Joshua; Browning, Kimberly; Deuel, Jake; Profitt, Bryan; Reibold, Marty

    2016-09-20

    During the week of August 22nd, 2016, over 150 technologists, stakeholders, and Department of Energy, Office of Environmental Management workers, met at DOE’s Portsmouth Gaseous Diffusion Plant in Ohio, for the EM Science of Safety Robotics Challenge.

  16. Near-atomic-resolution cryo-EM for molecular virology.

    PubMed

    Hryc, Corey F; Chen, Dong-Hua; Chiu, Wah

    2011-08-01

    Electron cryo-microscopy (cryo-EM) is a technique in structural biology that is widely used to solve the three-dimensional structures of macromolecular assemblies, close to their biological and solution conditions. Recent improvements in cryo-EM and single-particle reconstruction methodologies have led to the determination of several virus structures at near-atomic resolution (3.3 - 4.6 Å). These cryo-EM structures not only resolve the Cα backbones and side-chain densities of viral capsid proteins, but also suggest functional roles that the protein domains and some key amino acid residues play. This paper reviews the recent advances in near-atomic-resolution cryo-EM for probing the mechanisms of virus assembly and morphogenesis.

  17. EMS: A framework for data acquisition and analysis

    NASA Astrophysics Data System (ADS)

    Nogiec, J. M.; Sim, J.; Trombly-Freytag, K.; Walbridge, D.

    2001-08-01

    The Extensible Measurement System (EMS) is a universal Java framework for building data analysis and test systems. The objective of the EMS project is to replace a multitude of different existing systems with a single expandable system, capable of accommodating various test and analysis scenarios and varying algorithms. The EMS framework is based on component technology, graphical assembly of systems, introspection and flexibility to accommodate various data processing and data acquisition components. Core system components, common to many application domains, have been identified and designed together with the domain-specific components for the measurement of accelerator magnets. The EMS employs several modern technologies and the result is a highly portable, configurable, and potentially distributed system, with the capability of parallel signal data processing, parameterized test scripting, and run-time reconfiguration.

  18. EmPOWER Maryland - Leveraging relationships and experience

    EPA Pesticide Factsheets

    DHCD has gained a deep understanding of the needs of Maryland’s low-income residents and therefore was well-positioned to implement the low-income components of the broader EmPOWER Maryland energy efficiency initiative.

  19. Classification of ASASSN-17em/AT2017cts

    NASA Astrophysics Data System (ADS)

    Bersier, David

    2017-04-01

    We obtained a spectrum of the candidate supernova ASASSN-17em/AT2017cts (ATEL #10241), using the SPRAT spectrograph mounted on the robotic 2m Liverpool Telescope at the Roque de los Muchachos observatory (La Palma).

  20. Classification of ASASSN-17em/AT2017cts

    NASA Astrophysics Data System (ADS)

    Bersier, David

    2017-04-01

    We obtained a spectrum of the candidate supernova ASASSN-17em/AT2017cts (ATEL #10241), using the SPRAT spectrograph mounted on the robotic 2m Liverpool Telescope at the Roque de los Muchachos observatory (La Palma).