Intestine Transplant

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Contact Us | Buildings | NREL

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76 FR 60799 - Senior Executive Services (SES) Performance Review Board: Update

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-30

...-8700; telephone 202-712-0010; FAX 202-216- 3392; Internet E-mail address: [email protected] (for E-mail... General for Investigations. Robert S. Ross, Assistant Inspector General for Management. Lisa S. Goldfluss... Dempsey, Deputy Assistant Inspector General for Audit. Lisa Risley, Deputy Assistant Inspector General for...

Herbs at a Glance

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Supplemental Annuity Plan | Alaska Division of Retirement and Benefits

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Information Information Resources Forms Please enter your Email Address: Email Address Sign Up Changes Address Changes Apply for Retirement Insurance Enrollment Rollovers Report a Death Education AK Retirement

Teen Dating Violence

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About the Operation: Heart Transplant

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Contact Us | Geospatial Data Science | NREL

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Contact Us | Wind | NREL

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Methanol test

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... Safety and Health. Emergency Response Safety and Health Database. Methanol: systemic agent. Updated May 28, 2015. www. ... ADAM Health Solutions. About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

Advanced Password Tips and Tricks

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... email Looking for business guidance on privacy and security? Get Email Updates Blog Feed Facebook YouTube Twitter The Federal Trade Commission (FTC) is the nation’s consumer protection agency. The FTC works to prevent fraudulent, deceptive ...

Oral Vaccination Through Peyer's Patches: Update on Particle Uptake.

PubMed

Pais Soares, Edna Filipa; Fernandes Borges, Olga Maria

2018-01-01

Oral immunization has numerous advantages over parenteral administrations. In addition to ease administration, more effective pathogen elimination on the mucosa before spreading into the blood circulation, constitutes the main benefit. This is particularly true for pathogens that enter the body through the oral route. On the other hand, it is the most challenging administration route for peptides, proteins and recombinant antigens due to gastrointestinal (GI) tract, numerous barriers including the harsh environment and the inherent weak immunogenicity. In addition to the adjuvant properties, polymeric particles arise as the most promising strategy to overcome poor antigen bioavailability/ stability upon oral administration. The Peyer's patches have been considered an important structure of the gut associate lymphoid tissue (GALT) for the initiation of the immune response towards particulate oral antigens. The transport mechanism of both, nano and microparticles across intestinal mucosa, particularly throughout Peyer's patches, is discussed in this review. We provide a short and concise update (last decade) focused on the importance of particle physicochemical properties, M-cell ligands and size-dependent transport and intracellular fate concerning Peyer's patches targeted oral vaccination. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

77 FR 25406 - Consortium on “Concrete Rheology: Enabling Metrology (CREME)”: Membership Fee Update

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... Technology (NIST) published a notice of a public meeting, which was held on November 8, 2011, to explore the feasibility of establishing a NIST/Industry Consortium on Concrete Rheology: Enabling Metrology (CREME)''. The... INFORMATION CONTACT: Chiara Ferraris or Nicos Martys via email at [email protected]nist.gov ; [email protected]nist...

76 FR 52672 - President's National Security Telecommunications Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... instructions for submitting written comments. E-mail: [email protected]hq.dhs.gov . Include the docket number in the... call, the NSTAC members will receive an update regarding the progress of the NSTAC's Cloud Computing...

Register to Download the Future Automotive Systems Technology Simulator |

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Register to Download the Automotive Deployment Options Projection Tool |

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Alternative Fuels Data Center: Status Update: Ethanol Blender Pump

Science.gov Websites

someone by E-mail Share Alternative Fuels Data Center: Status Update: Ethanol Blender Pump Dispenser Certified (August 2010) on Facebook Tweet about Alternative Fuels Data Center: Status Update: Ethanol Blender Pump Dispenser Certified (August 2010) on Twitter Bookmark Alternative Fuels Data Center: Status

Preventing the forgotten ureteral stent: implementation of a web-based stent registry with automatic recall application.

PubMed

Lynch, Mark F; Ghani, Khurshid R; Frost, Ian; Anson, Ken M

2007-09-01

To describe and analyze a unique computerized system that tracks ureteral stents and automatically sends a notice by e-mail to clinical staff if a stent becomes overdue for removal. We have developed an electronic stent register (ESR) and stent extraction reminder facility (SERF) located within our hospital computer network. After stent insertion, a stent "episode" is created in the ESR with a mandatory maximal stent life (MSL). The SERF interrogates the ESR on a daily basis and identifies stents that have breached its MSL, generating daily e-mail notices to personnel until the stent is removed and the ESR updated. The episode data capture initially employing manual entry was changed to barcode technology acquisition. We analyzed the success of patient recall and conducted a prospective, blinded review to determine the success of the data acquisition. A total of 293 episodes were created within 2.4 years. Of the 241 (86%) episodes that were closed, 123 (51%) went beyond the MSL. The mean delay from designated MSL to stent removal was 20.89 days (SD 19.71). In the 7 months before barcode data acquisition, 43 of 71 stents were entered into the ESR (data capture rate 61%). In the 7 months after barcode data acquisition, 52 of 60 stents were entered (data capture rate 87%; P = 0.0009). The results of our study have shown the ESR and SERF to be robust and valuable tools for the treatment of patients with ureteral stents. Barcode acquisition significantly improved the stent insertion capture rate. This system ensures improved patient safety with an element of protection from potential litigation.

AAP Updates Recommendations on Car Seats

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... Size Email Print Share AAP Updates Recommendations on Car Seats Page Content Article Body Children should ride ... of approved car safety seats. Healthy Children Radio: Car Seat Safety Dennis Durbin, MD, FAAP, lead author ...

Get More TVDG Info

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77 FR 21622 - Special Medical Advisory Group; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-10

... Affiliations Council, ethics, an update on social services, and the White House initiative, ``Joining Forces... Administrative Operations (10B), VHA, 810 Vermont Avenue NW., Washington, DC 20420, or by email at j.t[email protected

Petrina White | Oregon State University Extension Service

Science.gov Websites

the "Get a new challenge" button which displays below the challenge text. Math question: * 6 + 6 = Solve this simple math problem and enter the result. E.g. for 1+3, enter 4. Send e-mail

32 CFR 2402.7 - Appeal of denials.

Code of Federal Regulations, 2013 CFR

2013-07-01

... National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY... email to [email protected] or by mail to: Chief FOIA Officer, Office of Science and Technology Policy, Eisenhower Executive Office Building, 1650 Pennsylvania Ave. NW., Washington, DC 20504. Updates...

77 FR 55864 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

..., October 29, 2011. NEWS MEDIA CONTACT: Telephone: (202) 314-6100. The press and public may enter the NTSB... the meeting via a live or archived webcast by accessing a link under ``News & Events'' on the NTSB....gov . FOR MEDIA INFORMATION CONTACT: Terry Williams (202) 314-6126 or by email at [email protected

77 FR 19302 - Navigation Safety Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-30

... INFORMATION CONTACT: If you have questions about this meeting, please contact Mr. Mike Sollosi, the NAVSAC... Mr. Dennis Fahr, at telephone 202-372-1531 or email [email protected] . If you have questions on... following topics: Tuesday, April 17, 2012 (1) Update on all past Resolutions to the Council. The Council...

77 FR 65536 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

... to ecosystem-based management; and consideration of updates to essential fish habitat policy... meeting of its Habitat and Environmental Protection Advisory Panel (AP) in Charleston, SC. DATES: The...) 769-4520; email: [email protected] . SUPPLEMENTARY INFORMATION: Members of the Habitat and...

78 FR 30306 - Partnerships To Advance the National Occupational Research Agenda (NORA)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... NORA and on plans for evaluating the second decade of NORA. Brief written updates will be available... (capacity 50). Each participant is requested to register for the free meeting by sending an email to...: computer, Internet connection, and telephone, preferably with `mute' capability). An email confirming...

77 FR 49054 - 60-Day Notice of Proposed Information Collection: Request for Commodity Jurisdiction...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

....regulations.gov . You can search for the document by selecting ``Notice'' under Document Type, entering the... ``Search.'' If necessary, use the ``Narrow by Agency'' option on the Results page. Email: [email protected] the burden of the proposed collection, including the validity of the methodology and assumptions used...

76 FR 77051 - Proposed Collection; Comment Request for Form 13704

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-09

... 13704, Health Coverage Tax Credit Registration Update Form. DATES: Written comments should be [email protected] . SUPPLEMENTARY INFORMATION: Title: Health Coverage Tax Credit Registration Update Form... taxpayers determine if they are eligible for the credit and understand what they need to do to continue to...

78 FR 69851 - Federal Advisory Committee Act; Communications Security, Reliability, and Interoperability Council

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-21

... present an update on topics including emergency warning systems, 9-1-1 location accuracy, distributed denial-of-service (DDoS), and cybersecurity best practices. DATES: December 4, 2013. ADDRESSES: Federal... Designated Federal Officer, by email to [email protected] or U.S. Postal Service Mail to Jeffery...

76 FR 47990 - Amendment to the International Traffic in Arms Regulations: Updates to Country Policies, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-08

...: Effective Date: This rule is effective August 8, 2011. FOR FURTHER INFORMATION CONTACT: Nicholas Memos...) 261-8199; or e-mail: [email protected] . Attn: Part 126, Country Policies. SUPPLEMENTARY INFORMATION... of the United States to deny licenses and other approvals for exports and imports of defense articles...

Diagnostic Testing at UK Universities: An E-Mail Survey

ERIC Educational Resources Information Center

Gillard, Jonathan; Levi, Margaret; Wilson, Robert

2010-01-01

In July 2009, an e-mail survey was sent to various UK universities to gain information regarding current practices concerning mathematics diagnostic testing, and to provide an update from the review "Diagnostic Testing for Mathematics" published by the LTSN MathsTEAM Project in 2003. A total of 38 university departments were contacted…

American Association for Clinical Chemistry

MedlinePlus

... did not need additional cardiac testing. Read the study LAB TESTS ONLINE USPSTF Updates Draft Recommendations on Cervical Cancer ... to follow colleagues and receive updates when they post in a forum, as well as enhanced email and messaging tools. Search ... AACC Programs and Partners Lab Tests Online Harmonization.net Commission on Accreditation in Clinical ...

Dissociating Working Memory Updating and Automatic Updating: The Reference-Back Paradigm

ERIC Educational Resources Information Center

Rac-Lubashevsky, Rachel; Kessler, Yoav

2016-01-01

Working memory (WM) updating is a controlled process through which relevant information in the environment is selected to enter the gate to WM and substitute its contents. We suggest that there is also an automatic form of updating, which influences performance in many tasks and is primarily manifested in reaction time sequential effects. The goal…

Webmail: an Automated Web Publishing System

NASA Astrophysics Data System (ADS)

Bell, David

A system for publishing frequently updated information to the World Wide Web will be described. Many documents now hosted by the NOAO Web server require timely posting and frequent updates, but need only minor changes in markup or are in a standard format requiring only conversion to HTML. These include information from outside the organization, such as electronic bulletins, and a number of internal reports, both human and machine generated. Webmail uses procmail and Perl scripts to process incoming email messages in a variety of ways. This processing may include wrapping or conversion to HTML, posting to the Web or internal newsgroups, updating search indices or links on related pages, and sending email notification of the new pages to interested parties. The Webmail system has been in use at NOAO since early 1997 and has steadily grown to include fourteen recipes that together handle about fifty messages per week.

76 FR 43230 - Outer Continental Shelf Air Regulations Consistency Update for Virginia

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

.... http://www.regulations.gov : Follow the on-line instructions for submitting comments. 2. E-mail: cox[email protected]ov . 3. Mail: EPA-R03-OAR-2011-0140, Kathleen Cox, Associate Director, Office of Permits and Air Toxics, Mailcode 3AP10, U.S. Environmental Protection Agency, Region III, 1650 Arch Street...

Environmental and Molecular Science Laboratory Arrow

DOE Office of Scientific and Technical Information (OSTI.GOV)

2016-06-24

Arrows is a software package that combines NWChem, SQL and NOSQL databases, email, and social networks (e.g. Twitter, Tumblr) that simplifies molecular and materials modeling and makes these modeling capabilities accessible to all scientists and engineers. EMSL Arrows is very simple to use. The user just emails chemical reactions to arrows@emsl.pnnl.gov and then an email is sent back with thermodynamic, reaction pathway (kinetic), spectroscopy, and other results. EMSL Arrows parses the email and then searches the database for the compounds in the reactions. If a compound isn't there, an NWChem calculation is setup and submitted to calculate it. Once themore » calculation is finished the results are entered into the database and then results are emailed back.« less

78 FR 38703 - LNG Development Company (d/b/a Oregon LNG); Oregon Pipeline Company, LLC; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

...://www.ferc.gov using the ``eLibrary'' link. Enter the docket number excluding the last three digits in..., Vancouver, WA 98662, (503) 298-4967, [email protected] or Lisa M. Tonery, Fulbright & Jaworski LLP, 666 Fifth Avenue, New York, NY 10103, (212) 318-3009, lisa[email protected] . On July 16, 2012...

Mirror, Mirror on the Wall: Email as an Object of Practitioner Inquiry

ERIC Educational Resources Information Center

Maxwell, Sally V.

2015-01-01

As new communication technologies enter the classroom, teachers must attend to how digital platforms impact the interpersonal practices of teaching and learning. In this article, I study email exchanges with three of my students--Jorge, Adriana, and Jason--over the course of one year in an 11th-grade English class at River High School, a…

Thalassemia

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75 FR 8698 - Extension of Request for Scientific Views for Draft 2009 Update Aquatic Life Ambient Water...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... following methods: www.regulations.gov : Follow the on-line instructions for submitting comments. E-mail: OW... www.regulations.gov or e-mail. The www.regulations.gov Web site is an ``anonymous access'' system... your comment. If you send an e- mail comment directly to EPA without going through www.regulations.gov...

Stop Ticks

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Prevent Shingles

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Preventing Suicide

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Enterobiasis (Pinworm Infection): Diagnosis

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Enterobiasis (Pinworm Infection): Treatment

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Wash Your Hands

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Avoid Mosquito Bites

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Oysters and Vibriosis

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26 CFR 301.6159-1 - Agreements for payment of tax liabilities in installments.

Code of Federal Regulations, 2012 CFR

2012-04-01

... must provide, a financial condition update at any time. (vi) At any time after entering into an... the installment agreement or a request for a financial update was inaccurate or incomplete in any... financial condition update requested by the Commissioner. (3) Request by taxpayer. Upon request by a...

26 CFR 301.6159-1 - Agreements for payment of tax liabilities in installments.

Code of Federal Regulations, 2013 CFR

2013-04-01

... must provide, a financial condition update at any time. (vi) At any time after entering into an... the installment agreement or a request for a financial update was inaccurate or incomplete in any... financial condition update requested by the Commissioner. (3) Request by taxpayer. Upon request by a...

26 CFR 301.6159-1 - Agreements for payment of tax liabilities in installments.

Code of Federal Regulations, 2011 CFR

2011-04-01

... must provide, a financial condition update at any time. (vi) At any time after entering into an... the installment agreement or a request for a financial update was inaccurate or incomplete in any... financial condition update requested by the Commissioner. (3) Request by taxpayer. Upon request by a...

26 CFR 301.6159-1 - Agreements for payment of tax liabilities in installments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... must provide, a financial condition update at any time. (vi) At any time after entering into an... the installment agreement or a request for a financial update was inaccurate or incomplete in any... financial condition update requested by the Commissioner. (3) Request by taxpayer. Upon request by a...

AIDSinfo

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Chicken and Food Poisoning

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Autism: Why Act Early?

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Medication Use during Pregnancy

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Learn About Cronobacter Infection

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Bleeding Disorders in Women

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Pregnant? Don't Smoke!

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Home Canning and Botulism

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Lupus among Asians and Hispanics

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Are You Getting Enough Sleep?

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Take Care with Pet Reptiles

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Hand, Foot and Mouth Disease

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Carbon Monoxide (CO) Poisoning Prevention

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Helping Children with Congenital CMV

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Circumcision - slideshow

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Vasectomy - slideshow

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Need yellow fever vaccine? Plan ahead

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Drowsy Driving: Asleep at the Wheel

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Prevent Type 2 Diabetes in Kids

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Help Protect Babies from Whooping Cough

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Test Your Knowledge of Spina Bifida

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Protect Your Child from Rotavirus Disease

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Knee arthroscopy - slideshow

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Testing Behavior Change Techniques to Encourage Primary Care Physicians to Access Cancer Screening Audit and Feedback Reports: Protocol for a Factorial Randomized Experiment of Email Content

PubMed Central

Witteman, Holly O; Bouck, Zachary; Bravo, Caroline A; Desveaux, Laura; Llovet, Diego; Presseau, Justin; Saragosa, Marianne; Taljaard, Monica; Umar, Shama; Grimshaw, Jeremy M; Tinmouth, Jill; Ivers, Noah M

2018-01-01

Background Cancer Care Ontario’s Screening Activity Report (SAR) is an online audit and feedback tool designed to help primary care physicians in Ontario, Canada, identify patients who are overdue for cancer screening or have abnormal results requiring follow-up. Use of the SAR is associated with increased screening rates. To encourage SAR use, Cancer Care Ontario sends monthly emails to registered primary care physicians announcing that updated data are available. However, analytics reveal that 50% of email recipients do not open the email and less than 7% click the embedded link to log in to their report. Objective The goal of the study is to determine whether rewritten emails result in increased log-ins. This manuscript describes how different user- and theory-informed messages intended to improve the impact of the monthly emails will be experimentally tested and how a process evaluation will explore why and how any effects observed were (or were not) achieved. Methods A user-centered approach was used to rewrite the content of the monthly email, including messages operationalizing 3 behavior change techniques: anticipated regret, material incentive (behavior), and problem solving. A pragmatic, 2x2x2 factorial experiment within a multiphase optimization strategy will test the redesigned emails with an embedded qualitative process evaluation to understand how and why the emails may or may not have worked. Trial outcomes will be ascertained using routinely collected administrative data. Physicians will be recruited for semistructured interviews using convenience and snowball sampling. Results As of April 2017, 5576 primary care physicians across the province of Ontario, Canada, had voluntarily registered for the SAR, and in so doing, signed up to receive the monthly email updates. From May to August 2017 participants received the redesigned monthly emails with content specific to their allocated experimental condition prompting use of the SAR. We have not yet begun analyses. Conclusions This study will inform how to communicate effectively with primary care providers by email and identify which behavior change techniques tested are most effective at encouraging engagement with an audit and feedback report. Trial Registration ClinicalTrials.gov NCT03124316; https://clinicaltrials.gov/ct2/show/NCT03124316 (Archived by WebCite at http://www.webcitation.org/6w2MqDWGu) PMID:29453190

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Medical Encyclopedia: MedlinePlus

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PubMed Informer: Monitoring MEDLINE/PubMed through E-mail Alerts, SMS, PDA downloads and RSS feeds

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Muin, Michael; Fontelo, Paul; Ackerman, Michael

2005-01-01

Summary PubMed Informer is a Web-based monitoring tool for topics of interest from MEDLINE/PubMed primarily designed for healthcare professionals. Five tracking methods are available: Web access, e-mail, Short Message Service (SMS), PDA downloads and RSS feeds. PubMed Informer delivers focused search updates and specific information to users with varying information-seeking practices. PMID:16779344

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Seeing the wood for the trees: a forest of methods for optimization and omic-network integration in metabolic modelling.

PubMed

Vijayakumar, Supreeta; Conway, Max; Lió, Pietro; Angione, Claudio

2017-05-30

Metabolic modelling has entered a mature phase with dozens of methods and software implementations available to the practitioner and the theoretician. It is not easy for a modeller to be able to see the wood (or the forest) for the trees. Driven by this analogy, we here present a 'forest' of principal methods used for constraint-based modelling in systems biology. This provides a tree-based view of methods available to prospective modellers, also available in interactive version at http://modellingmetabolism.net, where it will be kept updated with new methods after the publication of the present manuscript. Our updated classification of existing methods and tools highlights the most promising in the different branches, with the aim to develop a vision of how existing methods could hybridize and become more complex. We then provide the first hands-on tutorial for multi-objective optimization of metabolic models in R. We finally discuss the implementation of multi-view machine learning approaches in poly-omic integration. Throughout this work, we demonstrate the optimization of trade-offs between multiple metabolic objectives, with a focus on omic data integration through machine learning. We anticipate that the combination of a survey, a perspective on multi-view machine learning and a step-by-step R tutorial should be of interest for both the beginner and the advanced user. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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Survey of nutritional practices during therapeutic hypothermia for hypoxic-ischaemic encephalopathy

PubMed Central

Hazeldine, Beth; Thyagarajan, Balamurugan; Grant, Michellee; Chakkarapani, Elavazhagan

2017-01-01

Objective To evaluate current nutritional practices during and after therapeutic hypothermia (TH) for infants with hypoxic-ischaemic encephalopathy (HIE) in UK neonatal units. Study design Email survey of neonatal clinicians. Setting UK neonatal units providing active TH. Patients Neonates cooled for HIE. Methods Email survey including questions regarding the timing of starting enteral feeds, volumes, frequency and parenteral nutrition (PN) use and availability of guidelines. Results Forty-nine responses were received (49/69, 71%). The rate of enteral feeding during TH and rewarming was 59% (29/49). There was a significant linear trend for the increase in the proportion of units starting enteral feeds (p=0.001) during TH. As compared with post-TH period, significantly lower milk volumes were started during TH (median (range): 7.5 mL/kg/day (1.5–24) vs 17.5 mL/kg/day (7.5–30), p=0.0004). During TH, breast milk was primarily used by 52% of units predominantly as 2–3 hourly feeds, and volumes were increased as tolerated in 55% of units. Only 29% (14/49) of units used PN, with 86% (12/14) of those offering enteral feeds during PN. Guidelines for feeding during TH were available in 31% (15/49) of units. Conclusions Many neonatal clinicians offer enteral feeds predominantly using expressed breast milk, with or without PN, during TH, although with huge variability. The heterogeneity in the nutritional practice underscores the need for assessing the safety of both enteral and parenteral feeding during TH. PMID:29637095

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Testing Behavior Change Techniques to Encourage Primary Care Physicians to Access Cancer Screening Audit and Feedback Reports: Protocol for a Factorial Randomized Experiment of Email Content.

PubMed

Vaisson, Gratianne; Witteman, Holly O; Bouck, Zachary; Bravo, Caroline A; Desveaux, Laura; Llovet, Diego; Presseau, Justin; Saragosa, Marianne; Taljaard, Monica; Umar, Shama; Grimshaw, Jeremy M; Tinmouth, Jill; Ivers, Noah M

2018-02-16

Cancer Care Ontario's Screening Activity Report (SAR) is an online audit and feedback tool designed to help primary care physicians in Ontario, Canada, identify patients who are overdue for cancer screening or have abnormal results requiring follow-up. Use of the SAR is associated with increased screening rates. To encourage SAR use, Cancer Care Ontario sends monthly emails to registered primary care physicians announcing that updated data are available. However, analytics reveal that 50% of email recipients do not open the email and less than 7% click the embedded link to log in to their report. The goal of the study is to determine whether rewritten emails result in increased log-ins. This manuscript describes how different user- and theory-informed messages intended to improve the impact of the monthly emails will be experimentally tested and how a process evaluation will explore why and how any effects observed were (or were not) achieved. A user-centered approach was used to rewrite the content of the monthly email, including messages operationalizing 3 behavior change techniques: anticipated regret, material incentive (behavior), and problem solving. A pragmatic, 2x2x2 factorial experiment within a multiphase optimization strategy will test the redesigned emails with an embedded qualitative process evaluation to understand how and why the emails may or may not have worked. Trial outcomes will be ascertained using routinely collected administrative data. Physicians will be recruited for semistructured interviews using convenience and snowball sampling. As of April 2017, 5576 primary care physicians across the province of Ontario, Canada, had voluntarily registered for the SAR, and in so doing, signed up to receive the monthly email updates. From May to August 2017 participants received the redesigned monthly emails with content specific to their allocated experimental condition prompting use of the SAR. We have not yet begun analyses. This study will inform how to communicate effectively with primary care providers by email and identify which behavior change techniques tested are most effective at encouraging engagement with an audit and feedback report. ClinicalTrials.gov NCT03124316; https://clinicaltrials.gov/ct2/show/NCT03124316 (Archived by WebCite at http://www.webcitation.org/6w2MqDWGu). ©Gratianne Vaisson, Holly O Witteman, Zachary Bouck, Caroline A Bravo, Laura Desveaux, Diego Llovet, Justin Presseau, Marianne Saragosa, Monica Taljaard, Shama Umar, Jeremy M Grimshaw, Jill Tinmouth, Noah M Ivers. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 16.02.2018.

A Mixed-Methods Study of Patient-Provider E-mail Content in a Safety-Net Setting

PubMed Central

Mirsky, Jacob B.; Tieu, Lina; Lyles, Courtney; Sarkar, Urmimala

2016-01-01

Objective To explore the content of patient-provider e-mails in a safety-net primary care clinic. Methods We conducted a content analysis using inductive and deductive coding of e-mail exchanges (n=31) collected from January through November of 2013. Participants were English-speaking adult patients with a chronic condition (or their caregivers) cared for at a single publicly-funded general internal medicine clinic and their primary care providers (attending general internist physicians, clinical fellows, internal medicine residents, and nurse practitioners). Results All e-mails were non-urgent. Patients included a medical update in 19% of all e-mails. Patients requested action in 77% of e-mails, and the most common requests overall were for action regarding medications or treatment (29%). Requests for information were less common (45% of e-mails). Patient requests (n=56) were resolved in 84% of e-mail exchanges, resulting in 63 actions. Conclusion Patients in safety-net clinics are capable of safely and effectively using electronic messaging for between-visit communication with providers. Practical Implications Safety-net systems should implement electronic communications tools as soon as possible to increase healthcare access and enhance patient involvement in their care. PMID:26332306

Investigating the complex viral community of the turkey gut: an update from the laboratory and the field

USDA-ARS?s Scientific Manuscript database

Periodic monitoring of poultry flocks in the United States via molecular diagnostic methods has revealed a number of potential enteric viral pathogens in continuous circulation in turkeys and chickens. Recently, numerous enteric samples collected from turkey flocks in the southeastern United States ...

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Joint Airspace Control, Doctrine Update 10-06

DTIC Science & Technology

2010-05-20

Doctrine Update 10-06 Joint Publication 3-52, Joint Airspace Control JP 3-52 provides joint doctrine for airspace control across the full range...identification, combined operations, and unmanned aerial vehicle If you want read the complete new doctrine document, dated 20 May 2010, click here: JP 3-52...Joint Airspace Control. For more information, visit the LeMay Center for Doctrine Development and Education, call us at DSN 493-7442, or e-mail

E-mail in patient–provider communication: A systematic review

PubMed Central

Ye, Jiali; Rust, George; Fry-Johnson, Yvonne; Strothers, Harry

2014-01-01

Objective To review systematically the role of e-mails in patient–provider communication in terms of e-mail content, and perspectives of providers and patients on e-mail communication in health care. Methods A systematic review of studies on e-mail communication between patients and health providers in regular health care published from 2000 to 2008. Results A total of 24 studies were included in the review. Among these studies, 21 studies examined e-mail communication between patients and providers, and three studies examined the e-mail communication between parents of patients in pediatric primary care and pediatricians. In the content analyses of e-mail messages, topics well represented were medical information exchange, medical condition or update, medication information, and subspecialty evaluation. A number of personal and institutional features were associated with the likelihood of e-mail use between patients and providers. While benefits of e-mails in enhancing communication were recognized by both patients and providers, concerns about confidentiality and security were also expressed. Conclusion The e-mail is transforming the relationship between patients and providers. The rigorous exploration of pros and cons of electronic interaction in health care settings will help make e-mail communication a more powerful, mutually beneficial health care provision tool. Practice implications It is important to develop an electronic communication system for the clinical practice that can address a range of concerns. More efforts need to be made to educate patients and providers to appropriately and effectively use e-mail for communication. PMID:19914022

Providing accurate near real-time fire alerts for Protected Areas through NASA FIRMS: Opportunities and Challenges

NASA Astrophysics Data System (ADS)

Ilavajhala, S.; Davies, D.; Schmaltz, J. E.; Wong, M.; Murphy, K. J.

2013-12-01

The NASA Fire Information for Resource Management System (FIRMS) is at the forefront of providing global near real-time (NRT) MODIS thermal anomalies / hotspot location data to end-users . FIRMS serves the data via an interactive Web GIS named Web Fire Mapper, downloads of NRT active fire, archive data downloads for MODIS hotspots dating back to 1999 and a hotspot email alert system The FIRMS Email Alerts system has been successfully alerting users of fires in their area of interest in near real-time and/or via daily and weekly email summaries, with an option to receive MODIS hotspot data as a text file (CSV) attachment. Currently, there are more than 7000 email alert subscriptions from more than 100 countries. Specifically, the email alerts system is designed to generate and send an email alert for any region or area on the globe, with a special focus on providing alerts for protected areas worldwide. For many protected areas, email alerts are particularly useful for early fire detection, monitoring on going fires, as well as allocating resources to protect wildlife and natural resources of particular value. For protected areas, FIRMS uses the World Database on Protected Areas (WDPA) supplied by United Nations Environment Program - World Conservation Monitoring Centre (UNEP-WCMC). Maintaining the most up-to-date, accurate boundary geometry for the protected areas for the email alerts is a challenge as the WDPA is continuously updated due to changing boundaries, merging or delisting of certain protected areas. Because of this dynamic nature of the protected areas database, the FIRMS protected areas database is frequently out-of-date with the most current version of WDPA database. To maintain the most up-to-date boundary information for protected areas and to be in compliance with the WDPA terms and conditions, FIRMS needs to constantly update its database of protected areas. Currently, FIRMS strives to keep its database up to date by downloading the most recent WDPA database at regular intervals, processing it, and ingesting it into the FIRMS spatial database. However, due to the large size of database, the process to download, process and ingest the database is quite time consuming. The FIRMS team is currently working on developing a method to update the protected areas database via web at regular intervals or on-demand. Using such a solution, FIRMS will be able access the most up-to-date extents of any protected area and the corresponding spatial geometries in real time. As such, FIRMS can utilize such a service to access the protected areas and their associated geometries to keep users' protected area boundaries in sync with those of the most recent WDPA database, and thus serve a more accurate email alert to the users. Furthermore, any client accessing the WDPA protected areas database could potentially use the solution of real-time access to the protected areas database. This talk primarily focuses on the challenges for FIRMS in sending accurate email alerts for protected areas, along with the solution the FIRMS team is developing. This talk also introduces the FIRMS fire information system and its components, with a special emphasis on the FIRMS email alerts system.

Healthy habits for weight loss

MedlinePlus

... MedlinePlus GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español ... ADAM Health Solutions. About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

75 FR 82428 - VASRD Improvement Forum-Updating Disability Criteria for the Genitourinary System, Digestive...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... Scottsdale Road, in Scottsdale, Arizona. FOR FURTHER INFORMATION CONTACT: R. P. Watkins, Regulation Staff... contact Mr. Watkins at (202) 461-9214 or [email protected] . Dated: December 21, 2010. John R...

48 CFR 52.209-8 - Updates of Information Regarding Responsibility Matters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Updates of Information... Information System (FAPIIS) on a semi-annual basis, throughout the life of the contract, by entering the... Contractor's record in the system. Public requests for system information will be handled under Freedom of...

Postsecondary Transition under IDEA 2004: A Legal Update

ERIC Educational Resources Information Center

Prince, Angela M. T.; Katsiyannis, Antonis; Farmer, Jennie

2013-01-01

Postsecondary transition planning for students with disabilities first entered the Individuals with Disabilities Education Act (IDEA) in 1990. The required provisions for transition planning were updated with the amendments to IDEA in 1997 and its reauthorization in 2004. Since IDEA 2004 took effect in July 2005, 11 court cases have been decided…

Los Alamos National Laboratory: Phonebook

Science.gov Websites

Phonebook DexOnline DOE More Phonebooks Enter a name or email address. SEARCH TIPS: Search by name e.g. John or Doe or John Doe . This directory is U.S. Government property, published for the official business

Factors that impact nurses' use of electronic mail (e-mail).

PubMed

Hughes, J A; Pakieser, R A

1999-01-01

As electronic applications are used increasingly in healthcare, nurses are being challenged to adopt them. Electronic mail (e-mail) is an electronic tool with general as well as healthcare uses. E-mail use may be an opportunity to learn a tool that requires skills similar to those used in other applications. This study aimed to identify barriers and facilitators that impact nurses' use of e-mail in the workplace. Data for this study were gathered using focus group methodology. Content analysis identified and labeled factors into seven major categories. Specific factors identified were generally consistent with those previously described in the literature as affecting use of computers in general. However, there were several additional factors identified that were not reported in other previous studies: lack of face-to-face communication, individual writing skills, recency of any educational experience, volume of mail received, password integrity, and technical support. Findings from this study provide information for any individual involved in introducing or updating an e-mail system in a healthcare environment.

Cancer--Living with Cancer: MedlinePlus Health Topic

MedlinePlus

... MedlinePlus GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español ... our quality guidelines . About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

Health Topics: MedlinePlus

MedlinePlus

... Groups Seniors Women Health and Wellness Expand Section Disasters Fitness and Exercise Food and Nutrition Health System Personal Health Issues Safety Issues Sexual Health Issues Social/Family Issues Wellness and Lifestyle About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe ...

Dipylidium (Dog and Cat Flea Tapeworm) FAQs

MedlinePlus

... Page last updated: January 10, 2012 Content source: Global Health – Division of Parasitic Diseases Email Recommend Tweet YouTube Instagram Listen Watch RSS ABOUT About CDC Jobs Funding LEGAL Policies Privacy FOIA No Fear Act OIG 1600 Clifton ...

Email for clinical communication between healthcare professionals.

PubMed

Goyder, Clare; Atherton, Helen; Car, Mate; Heneghan, Carl J; Car, Josip

2015-02-20

Email is one of the most widely used methods of communication, but its use in healthcare is still uncommon. Where email communication has been utilised in health care, its purposes have included clinical communication between healthcare professionals, but the effects of using email in this way are not well known. We updated a 2012 review of the use of email for two-way clinical communication between healthcare professionals. To assess the effects of email for clinical communication between healthcare professionals on healthcare professional outcomes, patient outcomes, health service performance, and service efficiency and acceptability, when compared to other forms of communicating clinical information. We searched: the Cochrane Consumers and Communication Review Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 9 2013), MEDLINE (OvidSP) (1946 to August 2013), EMBASE (OvidSP) (1974 to August 2013), PsycINFO (1967 to August 2013), CINAHL (EbscoHOST) (1982 to August 2013), and ERIC (CSA) (1965 to January 2010). We searched grey literature: theses/dissertation repositories, trials registers and Google Scholar (searched November 2013). We used additional search methods: examining reference lists and contacting authors. Randomised controlled trials, quasi-randomised trials, controlled before and after studies, and interrupted time series studies examining interventions in which healthcare professionals used email for communicating clinical information in the form of: 1) unsecured email, 2) secure email, or 3) web messaging. All healthcare professionals, patients and caregivers in all settings were considered. Two authors independently assessed studies for inclusion, assessed the included studies' risk of bias, and extracted data. We contacted study authors for additional information and have reported all measures as per the study report. The previous version of this review included one randomised controlled trial involving 327 patients and 159 healthcare providers at baseline. It compared an email to physicians containing patient-specific osteoporosis risk information and guidelines for evaluation and treatment versus usual care (no email). This study was at high risk of bias for the allocation concealment and blinding domains. The email reminder changed health professional actions significantly, with professionals more likely to provide guideline-recommended osteoporosis treatment (bone density measurement or osteoporosis medication, or both) when compared with usual care. The evidence for its impact on patient behaviours or actions was inconclusive. One measure found that the electronic medical reminder message impacted patient behaviour positively (patients had a higher calcium intake), and two found no difference between the two groups. The study did not assess health service outcomes or harms.No new studies were identified for this update. Only one study was identified for inclusion, providing insufficient evidence for guiding clinical practice in regard to the use of email for clinical communication between healthcare professionals. Future research should aim to utilise high-quality study designs that use the most recent developments in information technology, with consideration of the complexity of email as an intervention.

Academic Literacy: A Statement of Competencies Expected of Students Entering California's Public Colleges and Universities.

ERIC Educational Resources Information Center

Academic Senate for California Community Colleges, Sacramento.

This document on Academic Literacies is an update of the original 1982 Statement on Competencies in English Expected of Entering College Freshmen. Incorporating findings from a Web-based survey submitted to faculty across the disciplines at the University of California , the California State Universities, and the California Community Colleges, and…

76 FR 53137 - Board of Scientific Counselors, National Center for Health Statistics, (BSC, NCHS)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... Regulation, Subpart 101-20.301, all persons entering in or on Federal controlled property and their packages... Discussed: The agenda will include welcome remarks by the Director, NCHS; update on the Health Indicators Warehouse; update on program reviews; discussion of the NHANES program, plans for the NHIS for 2012 and...

CDC Vital Signs: Progress on Children Eating More Fruit, Not Vegetables

MedlinePlus

... of Fruits and Vegetables [PDF – 2.1 MB] Childhood Obesity Prevention Strategies and Solutions for My Community School ... Progress in Obesity Prevention Institute of Medicine. Early Childhood Obesity Prevention Policies Top of Page Get Email Updates ...

77 FR 10784 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-23

... NEIGHBORHOOD REINVESTMENT CORPORATION Finance, Budget & Program Committee of the Board of...: Erica Hall, Assistant Corporate Secretary, (202) 220-2376; [email protected] . Agenda: I. Call to Order II. Executive Session III. Financial Report IV. NFMC Interest Income Budget V. Lease Update VI. Corporate...

MedlinePlus - Health Information from the National Library of Medicine

MedlinePlus

... MedlinePlus GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español ... Connect for EHRs About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

77 FR 31349 - Coastal Hydropower, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

...-Reynolds at (202) 502-6618, or via email at bryan.roden-reynolds@ferc.gov . Deadline for filing comments.../docs-filing/elibrary.asp . Enter the docket number (P-14385) in the docket number field to access the...

How to Find the Right Therapist

MedlinePlus

... Directory Get Involved Become a Member Attend an Event Annual OCD Conference 1 Million Steps 4 OCD Walk OCDvocate Program Fundraise Volunteer Share Your Story Join a Research Study Join our Email List For Professionals Training Add/Update a Referral Listing Apply for a Research ...

LANL Research Library

Science.gov Websites

Los Alamos National Laboratory The LANL Research Library website has been moved to http ://www.lanl.gov/library/. Please update your bookmarks. If you are not redirected to the new location within 10 http:// | Last Modified: Send email to the Library

Sexual Violence Prevention

MedlinePlus

... Intimate Partner and Sexual Violence Survey National Sexual Violence Resource Center Features Media Sign up for Features Get Email Updates To ... Center for Injury Prevention and Control, Division of Violence Prevention Page maintained by: Office of the Associate Director for Communication, Digital Media Branch, Division of Public Affairs ... ...

LSAT® Scores of Economics Majors: The 2012-13 Class Update

ERIC Educational Resources Information Center

Nieswiadomy, Michael

2014-01-01

Using 1994-95, 2002-3, and 2008-9 data, the author found that economics majors scored well on the LSAT® (1998, 2006, 2010). These results are often posted on university economics (and other) department Web sites. The author, who updates the prior studies using current data for law school applicants for the 2012-13 class of students entering law…

Etiquette for medical students' email communication with faculty members: a single-institution study.

PubMed

Kim, Do-Hwan; Yoon, Hyun Bae; Yoo, Dong-Mi; Lee, Sang-Min; Jung, Hee-Yeon; Kim, Seog Ju; Shin, Jwa-Seop; Lee, Seunghee; Yim, Jae-Joon

2016-04-27

Email is widely used as a means of communication between faculty members and students in medical education because of its practical and educational advantages. However, because of the distinctive nature of medical education, students' inappropriate email etiquette may adversely affect their learning as well as faculty members' perception of them. Little data on medical students' competency in professional email writing is available; therefore, this study explored the strengths and weaknesses of medical students' email etiquette and factors that contribute to professional email writing. A total of 210 emails from four faculty members at Seoul National University College of Medicine were collected. An evaluation criteria and a scoring rubric were developed based on the various email-writing guidelines. The rubric comprised 10 items, including nine items for evaluation related to the email components and one item for the assessment of global impression of politeness. Three evaluators independently assessed all emails according to the criteria. Students were identified as being 61.0% male and 52.8% were in the undergraduate-entry program. The sum of each component score was 62.21 out of 100 and the mean value for global impression was 2.6 out of 4. The results demonstrated that students' email etiquettes remained low-to-mediocre for most criteria, except for readability and honorifics. Three criteria, salutation (r=0.668), closing (r=0.653), and sign-off (r=0.646), showed a strong positive correlation with the global impression of politeness. Whether a student entered a graduate-entry program or an undergraduate-entry program significantly contributed to professional email writing after other variables were controlled. Although students in the graduate-entry program demonstrated a relatively superior level of email etiquette, the majority of medical students did not write emails professionally. Educating all medical students in email etiquette may well contribute to the improvement of student-faculty relationships as well as their email writing.

Crispen's Five Antivirus Rules.

ERIC Educational Resources Information Center

Crispen, Patrick Douglas

2000-01-01

Explains five rules to protect computers from viruses. Highlights include commercial antivirus software programs and the need to upgrade them periodically (every year to 18 months); updating virus definitions at least weekly; scanning attached files from email with antivirus software before opening them; Microsoft Word macro protection; and the…

75 FR 35099 - Privacy Act of 1974: Update and Amend System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-21

... result in a contrary determination. ADDRESSES: Send written comments to the Group Manager, Employee... INFORMATION CONTACT: Willie Powers, Group Manager, [email protected] . SUPPLEMENTARY INFORMATION: The... medical, personnel, dispensary, health, safety, or other designated offices within the agency, or...

Variant (Swine Origin) Influenza Viruses in Humans

MedlinePlus

... Need To Know About Influenza (Flu) Reports of Human Infections with Variant Viruses Resources Print Materials Key Facts for People Exhibiting Pigs at Fairs [545 KB, 2 pages] Take Action to Prevent the Spread of Flu Between People and Pigs ... Viruses Get Email Updates To ...

75 FR 104 - Manufacturing & Services' Sustainable Manufacturing Initiative; Update

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... with the private sector to determine the appropriate role of the federal government in establishing... publicize legislative and regulatory information and analyses that would enhance private sector... 20230 (or via the Internet at [email protected] ). FOR FURTHER INFORMATION CONTACT: William McElnea...

76 FR 44902 - FFP Project 90, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... Contact: Bryan Roden-Reynolds at (202) 502-6618, or via e-mail at bryan.roden-reynolds@ferc.gov . Deadline... http://www.ferc.gov/docs-filing/elibrary.asp . Enter the docket number (P-14218) in the docket number...

Pancreatitis - discharge

MedlinePlus

... Diet - clear liquid Diet - full liquid Enteral nutrition - child - managing problems Gallstones - discharge Gastrostomy feeding tube - bolus Jejunostomy feeding tube Review Date 12/1/2016 Updated by: Subodh K. Lal, MD, Gastroenterologist ...

75 FR 67424 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NYSE Amex LLC Amending...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... basis. NYSE Amex represents that any Customer Electronic Complex Orders entered to the NYSE Amex System..., or a Stock/Complex Order must be entered into the NYSE Amex System and displayed at a total or net...) To Define Stock/ Complex Orders, Rule 963NY(d) To Update and Clarify the Priority of Complex Orders...

New Records and Updated Checklist of Phlebotomine Sand Flies (Diptera: Psychodidae) From Liberia.

PubMed

Obenauer, P J; Rueda, L M; El-Hossary, S S; Watany, N; Stoops, C A; Fakoli, L S; Bolay, F K; Diclaro, J W

2016-05-01

Phlebotomine sand flies from three counties in Liberia were collected from January 2011 to July 2013. In total, 3,118 sand flies were collected: 18 species were identified, 13 of which represented new records for Liberia. An updated taxonomic checklist is provided with a brief note on sand fly biology, and the disease vector potential for species is discussed. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Anxious Behaviors of Patrons of an X-Rated Movie: An Update of the Winick Study for the Commission on Obscenity and Pornography.

ERIC Educational Resources Information Center

Copeland, Gary A.; Davis, Donald M.

A study examined the behavior patterns of patrons arriving at theatres that showed both "X" rated and "PG" rated movies. The study was undertaken to update the findings of the President's Commission on Pornography and Obscenity, which conducted similar research in 1970 and 1971. Patrons entering the theatre's X and PG rated…

75 FR 28307 - Privacy Act of 1974: Update and Amend System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... information in support of Homeland Defense initiatives.'' CATEGORIES OF RECORDS IN THE SYSTEM: Delete entry... addresses, phone numbers, and e-mail addresses; employment history; military record information; selective service registration record; residential history; education and degrees earned; names of associates and...

Personnel - National Site for the Regional IPM Centers

Science.gov Websites

, California 95618 Phone: 530-750-1269 Email: sfelliott@ucdavis.edu United States Department of Agriculture - National Institute of Food and Agriculture Website managed by the Southern IPM Center. Design adapted from of Food and Agriculture. Last update: June 26, 2015.

A Cyberworm that Knows no Boundaries

DTIC Science & Technology

2011-01-01

Stack, 2009. During Iran’s so-called “Twitter revolution,” Twitter feeds off ered a constant stream of situational updates and links to photos and...20090721141526-32619.pdf Baldor, Lolita , “Pentagon Gets Cyberwar Guidelines,” Associated Press, June 22, 2011. Balkovich, Edward, email to the authors

77 FR 58114 - SunShot Prize: Race to the Rooftop

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... who can lower the non-hardware installation cost of rooftop solar energy systems. DATES: Registration....energy.gov/solar/sunshot/prize.html . Teams that wish to enter the competition can register at eere.energy.gov/solar/sunshot/prize.html . Questions about the prize competition can be sent to: Email: Sun...

The E-Mail Lab

ERIC Educational Resources Information Center

Lederman, Judith; Gnanakkan, Dionysius; Bartels, Selina; Lederman, Norman

2015-01-01

Many students enter high school with some science knowledge and experience doing investigations but often know little about the nature of science (NOS) or how the knowledge is developed (i.e., science practices). As science teachers, we need to get students excited about science as quickly as possible with activities that introduce the practices…

78 FR 7816 - NASA Advisory Council; Aeronautics Committee; Unmanned Aircraft Systems Subcommittee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

....m. to 4:30 p.m., Local Time. ADDRESSES: National Aeronautics and Space Administration Headquarters... and Space Administration Headquarters, Washington, DC 20546, (202) 358-1578, or [email protected], officially- issued picture identification such as driver's license to enter the NASA Headquarters building...

Space Acquisitions: GAO Assessment of DOD Responsive Launch Report

DTIC Science & Technology

2015-10-29

foreign governments or industry ; 2. conditions or requirements for responsive launch that would provide the necessary military value; 3. various...Facebook, Flickr, Twitter, and YouTube. Subscribe to our RSS Feeds or E-mail Updates. Listen to our Podcasts . Visit GAO on the web at www.gao.gov

75 FR 3461 - Minnesota Energy Resources Corporation; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-21

... Resources Corporation; Notice of Filing January 13, 2010. Take notice that on December 29, 2009, Minnesota Energy Resources Corporation (MERC) filed to update the state approved rate for services under its... subscribers to receive e-mail notification when a document is added to a subscribed docket(s). For assistance...

77 FR 70211 - Agency Information Collection Activities Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

... FURTHER INFORMATION CONTACT: Crystal Rennie, Enterprise Records Service (005R1B), Department of Veterans...: crystal[email protected] . Please refer to ``OMB Control No. 2900-New (NCA Emerging Burial Survey Needs... by VA at that time. NCA now seeks to both update the their understanding of the Veterans...

NOAA Photo Library - Contacts

Science.gov Websites

NOAA Photo Library Banner Takes you to the Top Page Takes you to the About this Site page. Takes concerning this site, please contact: NOAA Photo Library NOAA Central Library Email: photolibrary@noaa.gov Library NOAA Privacy Policy | NOAA Disclaimer Last Updated: September 30, 2009

MedlinePlus en español marks its 10th anniversary

MedlinePlus

... frequently among the top 5 on the American Customer Satisfaction Index (ACSI) E‑Government Satisfaction Index. The site has come a long way since it started. As the U.S. Hispanic population has grown, so too has MedlinePlus en ... email updates Subscribe to RSS Follow ...

77 FR 24538 - Sunshine Act Meeting Notice; Finance, Budget & Program; Committee Meeting of the Board of Directors

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... NEIGHBORHOOD REINVESTMENT CORPORATION Sunshine Act Meeting Notice; Finance, Budget & Program...: Erica Hall, Assistant Corporate Secretary, (202) 220-2376; [email protected] . AGENDA: I. Call to Order II.../Dashboard VII. NFMC & EHLP VIII. Program Updates IX. Adjournment Erica Hall, Assistant Corporate Secretary...

76 FR 67764 - Finance, Budget & Program Committee Board of Directors Meeting; Sunshine Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

... NEIGHBORHOOD REINVESTMENT CORPORATION Finance, Budget & Program Committee Board of Directors..., Assistant Corporate Secretary (202) 220-2376; [email protected] . Agenda: I. Call To Order II. Executive Session III. Financial Report III. Budget Report IV. Lease Update V. Corporate Scorecard VI. NFMC & EHLP VII...

76 FR 55125 - Finance, Budget & Program Committee Meeting of the Board of Directors; Sunshine Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... NEIGHBORHOOD REINVESTMENT CORPORATION Finance, Budget & Program Committee Meeting of the Board of..., Assistant Corporate Secretary, (202) 220-2376; [email protected] . AGENDA: I. CALL TO ORDER II. Financial Report III. Budget Report IV. Lease Update V. Corporate Scorecard VI. National Foreclosure Mitigation...

78 FR 24438 - Board of Directors Finance, Budget & Program Committee: Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-25

... NEIGHBORHOOD REINVESTMENT CORPORATION Board of Directors Finance, Budget & Program Committee... Corporate Secretary (202) 220-2376; [email protected] . AGENDA: I. CALL TO ORDER II. FY 2013 Budget Update III... Corporate Milestone Report and Dashboard IX. NFMC, EHLP & MHA X. NeighborhoodLIFT & CityLIFT XI. Recent...

State Solar Technical Assistance | State, Local, and Tribal Governments |

Science.gov Websites

NREL State Solar Technical Assistance State Solar Technical Assistance Request Assistance Subscribe to Email Updates NREL provides direct technical assistance to state and local governments on expert testimony on policy best practices. The Solar Technical Assistance Team (STAT) Network is designed

78 FR 71675 - Update of the Office of Nuclear Reactor Regulation's Electronic Operating Reactor Correspondence

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-29

... correspondence to addressees and subscribers through a computer-based email distribution system. Since then, the... Electronic Operating Reactor Correspondence The U.S. Nuclear Regulatory Commission (NRC) is issuing this... available operating reactor licensing correspondence, effective December 9, 2013. Official agency records...

Think Visual

ERIC Educational Resources Information Center

Thomas, Lisa Carlucci

2012-01-01

Photographs tell a story and illustrate an experience more profoundly than words alone. Real-time, text-based communication is an increasingly normal part of daily life as mobile devices and social networks proliferate. Yet, in the steady stream of tweets, comments, status updates, notifications, and e-mail, the details are easily lost in the…

76 FR 26603 - Reorganization of Sector North Carolina; Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... Carolina's Marine Inspection Zone and Captain of the Port Zone, and provide updated contact information....'' FOR FURTHER INFORMATION CONTACT: If you have questions on this rule, call or e-mail LT Kevin Sullivan..., which also contain contact details and other references to Sector North Carolina. This technical...

Audit of a sexual health website email link for general practitioners.

PubMed

Biggs, K; Lowe, P; Walsh, J; Lagios, K

2010-01-01

The aim of this review was to evaluate an 'Email a Clinician' link on a medically reviewed sexual health website, which was established to allow general practitioners (GPs) to communicate remotely with sexual health clinic specialists. The website was developed in consultation with GPs and extensively promoted throughout the relevant professional primary health-care networks. Despite this, the email link appeared to fail in its objective of facilitating GP access to specialist sexual health physician opinion within five working days. An audit examining use of the email link was conducted for a one-year period, during which time 324 emails were received. Results showed that the bulk of the emails (93.2%) were spam, and only 6.8% were genuine enquiries. Of the 22 genuine emails, 21 (95%) originated from the general public and there were no enquiries from the GPs, who were the target audience of the website, resulting in removal of the email link from the site. Direct survey of local GPs to evaluate reasons for non-utilization of the link was not possible. However, discomfort with the technology, time added to existing workload, lack of direct perceived benefit and lack of immediate response have been cited as contributing factors that may limit widespread adoption of other telemedicine services. As a new generation of recently graduated GPs enters the Australian workforce, who might be expected to be skilled and comfortable with electronic medical communication, the option of a direct email link to a sexual health clinic, with a faster turnaround time, may be worth re-visiting in the future.

Chief of Naval Air Training Automated Management Information System (CAMIS). User’s Guide.

DTIC Science & Technology

1982-04-01

display. This display allows the user to insert, update, delete , or analyze various data elements, or generate reports. The Flight Schedule Input...instructor, student, and aircraft utiliza- tion. Additionally, it provides a means to delete any erroneous sortie information previously entered. 5...appear: 10 Technical Report 121 VT-## FLIGHT SCHEDULE PROGRAM 1. ADD NEW FLIGHT SCHEDULE DATA 2. DELETE ERRONEOUS SORTIES PREVIOUSLY ENTERED KEY IN

A Content Analysis of E-mail Communication between Patients and Their Providers: Patients Get the Message

PubMed Central

White, Casey B.; Moyer, Cheryl A.; Stern, David T.; Katz, Steven J.

2004-01-01

Objective: E-mail use in the clinical setting has been slow to diffuse for several reasons, including providers' concerns about patients' inappropriate and inefficient use of the technology. This study examined the content of a random sample of patient–physician e-mail messages to determine the validity of those concerns. Design: A qualitative analysis of patient–physician e-mail messages was performed. Measurements: A total of 3,007 patient–physician e-mail messages were collected over 11 months as part of a randomized, controlled trial of a triage-based e-mail system in two primary care centers (including 98 physicians); 10% of messages were randomly selected for review. Messages were coded across such domains as message type, number of requests per e-mail, inclusion of sensitive content, necessity of a physician response, and message tone. Results: The majority (82.8%) of messages addressed a single issue. The most common message types included information updates to the physicians (41.4%), prescription renewals (24.2%), health questions (13.2%), questions about test results (10.9%), referrals (8.8%), “other” (including thank yous, apologies) (8.8%), appointments (5.4%), requests for non-health-related information (4.8%), and billing questions (0.3%). Overall, messages were concise, formal, and medically relevant. Very few (5.1%) included sensitive content, and none included urgent messages. Less than half (43.2%) required a physician response. Conclusion: A triage-based e-mail system promoted e-mail exchanges appropriate for primary care. Most patients adhered to guidelines aimed at focusing content, limiting the number of requests per message, and avoiding urgent requests or highly sensitive content. Thus, physicians' concerns about the content of patients' e-mails may be unwarranted. PMID:15064295

Upgrade to the Cryogenic Hydrogen Gas Target Monitoring System

NASA Astrophysics Data System (ADS)

Slater, Michael; Tribble, Robert

2013-10-01

The cryogenic hydrogen gas target at Texas A&M is a vital component for creating a secondary radioactive beam that is then used in experiments in the Momentum Achromat Recoil Spectrometer (MARS). A stable beam from the K500 superconducting cyclotron enters the gas cell and some incident particles are transmuted by a nuclear reaction into a radioactive beam, which are separated from the primary beam and used in MARS experiments. The pressure in the target chamber is monitored so that a predictable isotope production rate can be assured. A ``black box'' received the analog pressure data and sent RS232 serial data through an outdated serial connection to an outdated Visual Basic 6 (VB6) program, which plotted the chamber pressure continuously. The black box has been upgraded to an Arduino UNO microcontroller [Atmel Inc.], which can receive the pressure data and output via USB to a computer. It has been programmed to also accept temperature data for future upgrade. A new computer program, with updated capabilities, has been written in Python. The software can send email alerts, create audible alarms through the Arduino, and plot pressure and temperature. The program has been designed to better fit the needs of the users. Funded by DOE and NSF-REU Program.

Knowledge structure representation and automated updates in intelligent information management systems

NASA Technical Reports Server (NTRS)

Corey, Stephen; Carnahan, Richard S., Jr.

1990-01-01

A continuing effort to apply rapid prototyping and Artificial Intelligence techniques to problems associated with projected Space Station-era information management systems is examined. In particular, timely updating of the various databases and knowledge structures within the proposed intelligent information management system (IIMS) is critical to support decision making processes. Because of the significantly large amounts of data entering the IIMS on a daily basis, information updates will need to be automatically performed with some systems requiring that data be incorporated and made available to users within a few hours. Meeting these demands depends first, on the design and implementation of information structures that are easily modified and expanded, and second, on the incorporation of intelligent automated update techniques that will allow meaningful information relationships to be established. Potential techniques are studied for developing such an automated update capability and IIMS update requirements are examined in light of results obtained from the IIMS prototyping effort.

Text(ing) in Context: The Future of Workplace Communication in the United States

ERIC Educational Resources Information Center

Kiddie, Thomas J.

2014-01-01

Following Rogers's theory of the diffusion of innovations, the author questions whether youth entering the workforce will act as change agents to evolve primary business communication channels from email to text-messaging. Expanding on research performed in 2009, the author investigates three communication scenarios: scheduling meetings,…

78 FR 41689 - Safety Zone; Skagit River Bridge, Skagit River, Mount Vernon, WA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-11

... Management Facility in Room W12-140 on the ground floor of the Department of Transportation West Building... email LTJG Nathaniel Clinger, Waterways Management Division, Coast Guard Sector Puget Sound; Coast Guard...; thence west back to the point of origin. Vessels wishing to enter the zone must request permission for...

Paralyzed Veterans of America

MedlinePlus

... Connected Twitter @PVA1946 Facebook @Paralyzed Veterans of America Instagram @PVA1946 National Veterans Wheelchair Games App Download Now ... 838-7782 CONNECT WITH US Facebook Twitter YouTube Instagram Flickr STAY INFORMED WITH NEWS & UPDATES Enter your ...

Board of Pesticides Control: Maine ACF

Science.gov Websites

| Search Maine.gov Department of Agriculture, Conservation and Forestry Contact Us | Get Email/SMS Updates ; Programs → Bureau of Agriculture → Division of Animal and Plant Health → Board of Pesticides Control Plates Outdoor Heritage Fund Lottery Ticket Donations & More Contact Department of Agriculture

77 FR 68155 - Finance, Budget & Program Committee Meeting of the Board of Directors; Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-15

... NEIGHBORHOOD REINVESTMENT CORPORATION Finance, Budget & Program Committee Meeting of the Board of...: Erica Hall, Assistant Corporate Secretary, (202) 220-2376; [email protected] . AGENDA: I. Call To Order II. Executive Session III. Budget Update IV. Committee Charter Review V. Financial Report VI. Corporate...

78 FR 12302 - President's Council of Advisors on Science and Technology (PCAST)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... Initiative, graduate education, and an update on the PCAST energy and climate change letter report...). Public Comments: It is the policy of the PCAST to accept written public comments of any length, and to... Acting Executive Director, at [email protected] , (202) 456-4444. Please note that public seating for...

76 FR 50815 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... longer accept paper submissions or electronic media (i.e., as a file on a CD- ROM) for any CDR submission...-mail address: [email protected] . SUPPLEMENTARY INFORMATION: I. Does this action apply to me? You... byproduct chemical substance (NAICS codes 22, 322, 331, and 3344; e.g., utilities, paper manufacturing...

Networked: The New Social Operating System

ERIC Educational Resources Information Center

Rainie, Lee; Wellman, Barry

2012-01-01

Daily life is connected life, its rhythms driven by endless email pings and responses, the chimes and beeps of continually arriving text messages, tweets and retweets, Facebook updates, pictures and videos to post and discuss. Our perpetual connectedness gives us endless opportunities to be part of the give-and-take of networking. Some worry that…

Ovrseas Real Property: State Department Needs to Improve Guidance and Records Management

DTIC Science & Technology

2014-09-25

next to two additional unneeded properties they had been attempting to sell since 2011, would possibly depress the disposal price if Page 15...for additional information. Connect with GAO on Facebook, Flickr, Twitter, and YouTube . Subscribe to our RSS Feeds or E-mail Updates. Listen to our

Military Health Care: Army Needs to Improve Oversight of Warrior Transition Units

DTIC Science & Technology

2016-07-01

traumatic stress disorder, such as major depression , anxiety disorder, panic disorder, and schizophrenia. Our analysis of these data showed that in 2008...Twitter, and YouTube . Subscribe to our RSS Feeds or E-mail Updates. Listen to our Podcasts and read The Watchblog. Visit GAO on the web at

78 FR 39057 - Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... of Availability. SUMMARY: The FAA is issuing this notice to advise the public that a Written Re..., Burlington, MA 01803, (781) 238-7613, or at [email protected]gov . SUPPLEMENTARY INFORMATION: The FAA has issued a Written Re-Evaluation and Record of Decision, which evaluates an updated noise mitigation...

Current Development at the Southern California Earthquake Data Center (SCEDC)

NASA Astrophysics Data System (ADS)

Appel, V. L.; Clayton, R. W.

2005-12-01

Over the past year, the SCEDC completed or is near completion of three featured projects: Station Information System (SIS) Development: The SIS will provide users with an interface into complete and accurate station metadata for all current and historic data at the SCEDC. The goal of this project is to develop a system that can interact with a single database source to enter, update and retrieve station metadata easily and efficiently. The system will provide accurate station/channel information for active stations to the SCSN real-time processing system, as will as station/channel information for stations that have parametric data at the SCEDC i.e., for users retrieving data via STP. Additionally, the SIS will supply information required to generate dataless SEED and COSMOS V0 volumes and allow stations to be added to the system with a minimum, but incomplete set of information using predefined defaults that can be easily updated as more information becomes available. Finally, the system will facilitate statewide metadata exchange for both real-time processing and provide a common approach to CISN historic station metadata. Moment Tensor Solutions: The SCEDC is currently archiving and delivering Moment Magnitudes and Moment Tensor Solutions (MTS) produced by the SCSN in real-time and post-processing solutions for events spanning back to 1999. The automatic MTS runs on all local events with magnitudes > 3.0, and all regional events > 3.5. The distributed solution automatically creates links from all USGS Simpson Maps to a text e-mail summary solution, creates a .gif image of the solution, and updates the moment tensor database tables at the SCEDC. Searchable Scanned Waveforms Site: The Caltech Seismological Lab has made available 12,223 scanned images of pre-digital analog recordings of major earthquakes recorded in Southern California between 1962 and 1992 at http://www.data.scec.org/research/scans/. The SCEDC has developed a searchable web interface that allows users to search the available files, select multiple files for download and then retrieve a zipped file containing the results. Scanned images of paper records for M>3.5 southern California earthquakes and several significant teleseisms are available for download via the SCEDC through this search tool.

"Go local" island food network: using email networking to promote island foods for their health, biodiversity, and other "CHEEF" benefits.

PubMed

Englberger, L; Lorens, A; Pretrick, M E; Spegal, R; Falcam, I

2010-04-01

Dietary- and lifestyle-related diseases are problems of epidemic proportion in the Federated States of Micronesia (FSM). Public health resources to help prevent nutrition-related problems are limited. There is also concern about biodiversity, neglect of traditional staple foods, and threatened loss of traditional knowledge. A "Go Local" campaign was initiated to increase production and consumption of locally grown foods, for their Culture, Health, Environment, Economics, and Food security ("CHEEF") benefits. To provide updates and discuss local island food topics, the Island Food Community of Pohnpei launched an interagency email network in 2003. Interested members' email addresses were recorded in distribution lists, weekly/bi-weekly emails were sent and from these messages, a database was organized to record email topic details. An analysis of all emails up to July 2009 showed that membership had expanded to over 600 listed people from all FSM states, other Pacific Island countries and beyond. Information was shared on topics ranging from scientific findings of carotenoid content in local island food cultivars, to discussions on how daily habits related to island food use can be improved. Over 200 men and women, aged 22 to 80 years, contributed items, some indicating that they had shared emails to a further network at their workplace or community. In conclusion, this email network is a simple, cost-effective method to share information, create awareness, and mobilize island food promotion efforts with potential for providing health, biodiversity and other benefits of island foods to populations in the FSM and other countries.

The Suppression of Beta Oscillations in the Primate Supplementary Motor Complex Reflects a Volatile State During the Updating of Action Sequences.

PubMed

Hosaka, Ryosuke; Nakajima, Toshi; Aihara, Kazuyuki; Yamaguchi, Yoko; Mushiake, Hajime

2016-08-01

The medial motor areas play crucial but flexible roles in the temporal organizations of multiple movements. The beta oscillation of local field potentials is the predominant oscillatory activity in the motor areas, but the manner in which increases and decreases in beta power contribute to updating of multiple action plans is not yet fully understood. In the present study, beta and high-gamma activities in the supplementary motor area (SMA) and pre-SMA of monkeys were analyzed during performance of a bimanual motor sequence task that required updating and maintenance of the memory of action sequences. Beta power was attenuated during early delay periods of updating trials but was increased during maintenance trials, while there was a reciprocal increase in high-gamma power during updating trials. Moreover, transient attenuation of beta power during maintenance trials resulted in the erroneous selection of an action sequence. Therefore, it was concluded that the suppression of beta power during the early delay period reflects volatility of neural representation of the action sequence. This neural representation would be properly updated to the appropriate instructed action sequence via increases in high-gamma power in updating trials whereas it would be erroneously updated without the appropriate updating signal in maintenance trials. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

77 FR 31268 - Determination of Attainment for the Paul Spur/Douglas PM10

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... requirements under 40 CFR part 58.\\7\\ Furthermore, we concluded in our Technical System Audit Report concerning... www.regulations.gov or email. www.regulations.gov is an ``anonymous access'' system, and EPA will not...) in the nonattainment area, and entered into the EPA Air Quality System (AQS) database. Data from air...

77 FR 75251 - 60-Day Notice of Proposed Information Collection: ECA Exchange Student Surveys

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... notice by going to www.Regulations.gov . You can search for the document by entering ``Public Notice '' in the Search bar. If necessary, use the Narrow by Agency filter option on the Results page. Email... collection, including the validity of the methodology and assumptions used. Enhance the quality, utility, and...

49 CFR 375.505 - Must I write up a bill of lading?

Code of Federal Regulations, 2010 CFR

2010-10-01

... that was entered on the estimate and order for service. (5) When you transport on a collect-on-delivery basis, the name, address, and if furnished, the telephone number, facsimile number, or e-mail address of... certified mail, return receipt requested. (6) For non-guaranteed service, the agreed date or period of time...

IRIS Toxicological Review of Benzo[a]pyrene (Final Report) ...

EPA Pesticide Factsheets

EPA has finalized the Integrated Risk Information System (IRIS) assessment of benzo[a]pyrene. This assessment addresses the potential cancer and noncancer human health effects from long-term exposure to benzo[a]pyrene. Now final, this assessment will update the toxicological information on benzo[a]pyrene posted in 1987. EPA’s program and regional offices may use this assessment to inform decisions to protect human health. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for benzo[a]pyrene (BaP). The outcome of this project is an updated Toxicological Review and IRIS Summary for BaP that will be entered into the IRIS database.

Clinician's guide to assessing and counseling older drivers, 3rd Edition.

DOT National Transportation Integrated Search

2015-01-01

The American Geriatrics Society (AGS) entered into a cooperative agreement with the U. S . : Department of Transportations National Highway Traffic Safety Administration (NHTSA) to : update and expand the Physicians Guide to Assessing and Couns...

Going for the Gold: Identifying Academic-Quality Internet Resources

ERIC Educational Resources Information Center

Axford, Mary; Renfro, Crystal

2008-01-01

The purpose of this article is to review some of the key directories of Internet resources, with a special focus on those that announce new academic-quality resources. Significant facets of the directories that will be incorporated in the discussion include scope of coverage, update frequency, identification of any e-mail alerts or RSS feeds…

76 FR 72030 - Public Meeting of Motor Carrier Safety Advisory Committee and Joint Public Meeting With Medical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... MCSAC will meet to be updated on recently completed, FMCSA-sponsored research on motorcoach HOS and to begin the process of setting up a subcommittee to consider ideas and concepts on motorcoach HOS for... New Jersey Avenue SE., Washington, DC 20590, (202) 385-2395, [email protected] . Services for Individuals...

75 FR 26855 - North American Industry Classification System-Updates for 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

...) Summarizes the background for the proposed revisions to NAICS 2007 in Part I, (2) contains a summary of... subject NAICS12. Comments may also be sent via http://www.regulations.gov --a Federal E-Government Web... comments. OMB will include in the official record all comments received via FAX, Web site, e-mail, hardcopy...

Bulk Fuel Pricing: DOD Needs to Reevaluate Its Approach to Better Manage the Effect of Market Fluctuations

DTIC Science & Technology

2014-07-01

depression in the price of WTI was a result of rapid growth in U.S. and Canadian oil production, which overwhelmed the transportation infrastructure...additional information. Connect with GAO on Facebook, Flickr, Twitter, and YouTube . Subscribe to our RSS Feeds or E-mail Updates. Listen to our

78 FR 14847 - Topaz Exchange, LLC; Notice of Filing of Application for Registration as a National Securities...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-07

...\\ Amendment No. 1, among other things, includes changes to the Limited Liability Company Agreement and the... other things, provides updated information regarding the board of directors of ISE and the Corporate... Use the Commission's Internet comment form ( http://www.sec.gov/rules/sro.shtml ); or Send an email to...

A synopsis on the role of human papilloma virus infection in cervical cancer.

PubMed

Saeed, Mohd; Alshammari, Fawaz D; Alam, Md Jahoor; Sarim, Khan Mohd; Ahmad, Khurshid; Hussain, Talib; Khan, Mahvish; Kamal, Muhammad Amjad; Ashraf, Ghulam Md

2018-03-02

Cancer or abnormal growth of the cell is one of the major health problems of the world. There are about two hundred types of malignancies reported till date. In this review, a brief update on cancer, its causes and different types has been discussed along with updated statistics of patient's mortality. A brief overview of cervical cancer and its pathophysiology has been discussed with special emphasis on its causative agent, human papilloma virus (HPV). A brief introduction and update on genetics, molecular pathogenesis and prevalence of HPV and its role in cervical cancer have been added. This review will explore an updated status of cervical cancer and provide novel therapeutic approaches for targeting HPV in the context of molecular pathogenesis and genetics as possible treatments, which may be a boon for the developing countries to get rid of this lethal disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5 ...

EPA Pesticide Factsheets

EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for RDX. The outcome of this project is an updated Toxicological Review and IRIS Summary for RDX that will be entered into the IRIS database.

IRIS Toxicological Review of Benzo[a]pyrene (Public ...

EPA Pesticide Factsheets

EPA is developing an Integrated Risk Information System (IRIS) assessment of benzo[a]pyrene and has released the draft assessment for public comment and external peer review. When final, the assessment will appear on the IRIS database. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for benzo[a]pyrene (BaP). The outcome of this project is an updated Toxicological Review and IRIS Summary for BaP that will be entered into the IRIS database.

77 FR 27767 - Milford Hydro, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... Contact: Bryan Roden-Reynolds at (202) 502-6618, or via email at bryan.roden-reynolds@ferc.gov . Deadline... site at http://www.ferc.gov/docs-filing/elibrary.asp . Enter the docket number (P-14218) in the docket number field to access the document. For assistance, contact FERC Online Support. Dated: May 4, 2012...

DOD Financial Management: Additional Efforts Needed to Improve Audit Readiness of Navy Military Pay and Other Related Activities

DTIC Science & Technology

2015-09-01

accuracy and validity of selected basic pay and entitlement transactions the IPA tested. The IPA tested a statistical sample of 405 leave and earnings...Subscribe to our RSS Feeds or E-mail Updates. Listen to our Podcasts . Visit GAO on the web at www.gao.gov. Contact: Website: http://www.gao.gov/fraudnet

The Online Expectations of College-Bound Juniors and Seniors. E-Expectations Report, 2012

ERIC Educational Resources Information Center

Noel-Levitz, Inc, 2012

2012-01-01

Noel-Levitz, OmniUpdate, CollegeWeekLive, and NRCCUA[R] (National Research Center for College & University Admissions) conducted a survey of 2,000 college-bound juniors and seniors about their expectations for college Web sites, mobile usage, e-mail, and social media. Among the findings: (1) More than 50 percent of students said the Web played a…

Forget E-Mail: New Messaging Service Has Students and Professors Atwitter

ERIC Educational Resources Information Center

Young, Jeffrey R.

2008-01-01

Some professors, librarians, and administrators have begun using Twitter, a service that can blast very short notes (up to 140 characters) to select users' cell phones or computer screens. The practice is often called microblogging because people use it to send out pithy updates about their daily lives. No need to wait until you are back at your…

National Maps - Alaska - NOAA's National Weather Service

Science.gov Websites

select the go button to submit request City, St Go Sign-up for Email Alerts RSS Feeds RSS Feeds Warnings current Forecast for Alaska is produced by the NWS Anchorage Forecast Office. It is updated daily Skip Navigation Links weather.gov NOAA logo-Select to go to the NOAA homepage National Oceanic and

The Use of Online Current Awareness Services by Natural Sciences and Engineering Faculty at Western Michigan University

ERIC Educational Resources Information Center

Leatherman, Carrie C.; Eckel, Edward J.

2012-01-01

Nearly every commercial database that covers natural sciences and engineering offers some type of current awareness (CA) service that provides regular updates to users on current literature in a selected field of interest. Current awareness services include e-mail alerts, tables of contents, and RSS feeds. This study was designed to find out what…

sLORETA current source density analysis of evoked potentials for spatial updating in a virtual navigation task

PubMed Central

Nguyen, Hai M.; Matsumoto, Jumpei; Tran, Anh H.; Ono, Taketoshi; Nishijo, Hisao

2014-01-01

Previous studies have reported that multiple brain regions are activated during spatial navigation. However, it is unclear whether these activated brain regions are specifically associated with spatial updating or whether some regions are recruited for parallel cognitive processes. The present study aimed to localize current sources of event related potentials (ERPs) associated with spatial updating specifically. In the control phase of the experiment, electroencephalograms (EEGs) were recorded while subjects sequentially traced 10 blue checkpoints on the streets of a virtual town, which were sequentially connected by a green line, by manipulating a joystick. In the test phase of the experiment, the checkpoints and green line were not indicated. Instead, a tone was presented when the subjects entered the reference points where they were then required to trace the 10 invisible spatial reference points corresponding to the checkpoints. The vertex-positive ERPs with latencies of approximately 340 ms from the moment when the subjects entered the unmarked reference points were significantly larger in the test than in the control phases. Current source density analysis of the ERPs by standardized low-resolution brain electromagnetic tomography (sLORETA) indicated activation of brain regions in the test phase that are associated with place and landmark recognition (entorhinal cortex/hippocampus, parahippocampal and retrosplenial cortices, fusiform, and lingual gyri), detecting self-motion (posterior cingulate and posterior insular cortices), motor planning (superior frontal gyrus, including the medial frontal cortex), and regions that process spatial attention (inferior parietal lobule). The present results provide the first identification of the current sources of ERPs associated with spatial updating, and suggest that multiple systems are active in parallel during spatial updating. PMID:24624067

Evaluating an approach to improving the adoption rate of wireless drug library updates for smart pumps.

PubMed

Poppe, Lindsey B; Eckel, Stephen F

2011-01-15

An academic medical center's approach to improving the adoption rate of wireless drug library updates for smart pumps was evaluated. A multidisciplinary team composed of pharmacy, nursing, medical engineering, materials management, and patient equipment personnel at an academic medical center collaborated to update the drug libraries of more than 1800 smart pumps via a wireless control system. Two pilot tests were completed to identify and resolve issues before the live wireless update was attempted. The second pilot test, a passive approach, produced an adoption rate of 42% of 1804 pumps at the end of one week and a rate of 56% on day 10. The goal of 80% was not achieved until day 22. The change to an active multidisciplinary process three months later produced an adoption rate of 80% for 1869 pumps on day 10, resulting in a 45.4% increase in the adoption rate between the two trials on day 10 (p < 0.001). Communication regarding the updates was disseminated via e-mail to the entire organization, with fliers posted on all patient care units, and verbally during staff meetings. Patient equipment personnel manually tagged each pump with a blue zip tie after verifying the update to easily identify which pumps had been updated. Areas for improvement include increasing communication to the staff detailing when the update will occur and changing the day of the week the update is performed. A multidisciplinary team actively engaged in the updating of wireless i.v. smart pump drug libraries reduced the amount of time required to reach a goal adoption rate of 80%.

A2A adenosine receptor agonists and their potential therapeutic applications. An update.

PubMed

Guerrero, Angel

2018-03-12

In the last 20 years, an increasing interest of medicinal chemists on the development of potent and selective agonists and antagonists of adenosine receptors has been noticed due to the large impact they have shown in a variety of important biological processes and diseases. Among these, it should be mentioned vasodilation, inflammation, cancer, wound healing, ischemia reperfusion injury, Parkinson disease, infectious diseases, and other CNS disorders. In this review, I will provide an update of the structures of the A2A agonists known, their selectivity versus other adenosine receptors, and their latest therapeutic applications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Concurrency Attacks and Defenses

DTIC Science & Technology

2016-10-04

Enter name(s) of person(s) responsible for writing the report, performing the research, or credited with the content of the report. The form of...Amsterdam Avenue New York, NY 10027-7003 Tel.: 212-939-7012 Fax: 212-666-0140 Email : junfeng@cs.columbia.edu 2. Research Objectives...Multithreaded programs are getting increasingly pervasive and critical. Unfortunately, they remain extremely difficult to write . This difficulty has led to

Computerized Automated Reminder Diabetes System (CARDS): E-Mail and SMS Cell Phone Text Messaging Reminders to Support Diabetes Management

PubMed Central

Hanauer, David A.; Wentzell, Katherine; Laffel, Nikki

2009-01-01

Abstract Background: Cell phone text messaging, via the Short Messaging Service (SMS), offers the promise of a highly portable, well-accepted, and inexpensive modality for engaging youth and young adults in the management of their diabetes. This pilot and feasibility study compared two-way SMS cell phone messaging with e-mail reminders that were directed at encouraging blood glucose (BG) monitoring. Methods: Forty insulin-treated adolescents and young adults with diabetes were randomized to receive electronic reminders to check their BG levels via cell phone text messaging or e-mail reminders for a 3-month pilot study. Electronic messages were automatically generated, and participant replies with BG results were processed by the locally developed Computerized Automated Reminder Diabetes System (CARDS). Participants set their schedule for reminders on the secure CARDS website where they could also enter and review BG data. Results: Of the 40 participants, 22 were randomized to receive cell phone text message reminders and 18 to receive e-mail reminders; 18 in the cell phone group and 11 in the e-mail group used the system. Compared to the e-mail group, users in the cell phone group received more reminders (180.4 vs. 106.6 per user) and responded with BG results significantly more often (30.0 vs. 6.9 per user, P=0.04). During the first month cell phone users submitted twice as many BGs as e-mail users (27.2 vs. 13.8 per user); by month 3, usage waned. Conclusions: Cell phone text messaging to promote BG monitoring is a viable and acceptable option in adolescents and young adults with diabetes. However, maintaining interest levels for prolonged intervals remains a challenge. PMID:19848576

Computerized Automated Reminder Diabetes System (CARDS): e-mail and SMS cell phone text messaging reminders to support diabetes management.

PubMed

Hanauer, David A; Wentzell, Katherine; Laffel, Nikki; Laffel, Lori M

2009-02-01

Cell phone text messaging, via the Short Messaging Service (SMS), offers the promise of a highly portable, well-accepted, and inexpensive modality for engaging youth and young adults in the management of their diabetes. This pilot and feasibility study compared two-way SMS cell phone messaging with e-mail reminders that were directed at encouraging blood glucose (BG) monitoring. Forty insulin-treated adolescents and young adults with diabetes were randomized to receive electronic reminders to check their BG levels via cell phone text messaging or e-mail reminders for a 3-month pilot study. Electronic messages were automatically generated, and participant replies with BG results were processed by the locally developed Computerized Automated Reminder Diabetes System (CARDS). Participants set their schedule for reminders on the secure CARDS website where they could also enter and review BG data. Of the 40 participants, 22 were randomized to receive cell phone text message reminders and 18 to receive e-mail reminders; 18 in the cell phone group and 11 in the e-mail group used the system. Compared to the e-mail group, users in the cell phone group received more reminders (180.4 vs. 106.6 per user) and responded with BG results significantly more often (30.0 vs. 6.9 per user, P = 0.04). During the first month cell phone users submitted twice as many BGs as e-mail users (27.2 vs. 13.8 per user); by month 3, usage waned. Cell phone text messaging to promote BG monitoring is a viable and acceptable option in adolescents and young adults with diabetes. However, maintaining interest levels for prolonged intervals remains a challenge.

A Full Spectrum Case for the Heavy Force

DTIC Science & Technology

2011-03-01

PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Professor John Bonin Concepts, Doctrine, and General Officer Updates Office 8. PERFORMING...SPECTRUM CASE FOR THE HEAVY FORCE by Colonel Richard D. Creed, Jr. United States Army Dr. John Bonin Project...8 Ibid.; also. Programs Branch Common Operating Picture 2010 Briefing. 9 Colonel (R) John Bonin , Ph. D., in an email to the author on 21 DEC 10. Dr

Development of Medical Technology for Contingency Response to Marrow Toxic Agents

DTIC Science & Technology

2010-09-30

Contract Audit Agency DHHS Department of Health and Human Services DIY Do it yourself DKMS Deutsche Knochenmarkspenderdatei DMSO...contact information and complete an online Health History Questionnaire (HHQ) from the Do It Yourself Donor ( DIY ) online platform. Information...email and allows them to: Update their contact information Complete an online Health History Questionnaire (HHQ) from the Do It Yourself ( DIY ) donor

The Errors Sources Affect to the Results of One-Way Nested Ocean Regional Circulation Model

NASA Astrophysics Data System (ADS)

Pham, S. V.

2016-02-01

Pham-Van Sy1, Jin Hwan Hwang2 and Hyeyun Ku3 Dept. of Civil & Environmental Engineering, Seoul National University, KoreaEmail: 1phamsymt@gmail.com (Corresponding author) Email: 2jinhwang@snu.ac.krEmail: 3hyeyun.ku@gmail.comAbstractThe Oceanic Regional Circulation Model (ORCM) is an essential tool in resolving highly a regional scale through downscaling dynamically the results from the roughly revolved global model. However, when dynamic downscaling from a coarse resolution of the global model or observations to the small scale, errors are generated due to the different sizes of resolution and lateral updating frequency. This research evaluated the effect of four main sources on the results of the ocean regional circulation model (ORCMs) during downscaling and nesting the output data from the ocean global circulation model (OGCMs). Representative four error sources should be the way of the LBC formulation, the spatial resolution difference between driving and driven data, the frequency for up-dating LBCs and domain size. Errors which are contributed from each error source to the results of the ORCMs are investigated separately by applying the Big-Brother Experiment (BBE). Within resolution of 3km grid point of the ORCMs imposing in the BBE framework, it clearly exposes that the simulation results of the ORCMs significantly depend on the domain size and specially the spatial and temporal resolution of lateral boundary conditions (LBCs). The ratio resolution of spatial resolution between driving data and driven model could be up to 3, the updating frequency of the LBCs can be up to every 6 hours per day. The optimal domain size of the ORCMs could be smaller than the OGCMs' domain size around 2 to 10 times. Key words: ORCMs, error source, lateral boundary conditions, domain size Acknowledgement: This research was supported by grants from the Korean Ministry of Oceans and Fisheries entitled as "Developing total management system for the Keum river estuary and coast" and "Development of Technology for CO2 Marine Geological Storage". We also thank to the administrative supports of the Integrated Research Institute of Construction and Environmental Engineering of the Seoul National University.

Enteric disease episodes and the risk of acquiring a future sexually transmitted infection: a prediction model in Montreal residents.

PubMed

Caron, Melissa; Allard, Robert; Bédard, Lucie; Latreille, Jérôme; Buckeridge, David L

2016-11-01

The sexual transmission of enteric diseases poses an important public health challenge. We aimed to build a prediction model capable of identifying individuals with a reported enteric disease who could be at risk of acquiring future sexually transmitted infections (STIs). Passive surveillance data on Montreal residents with at least 1 enteric disease report was used to construct the prediction model. Cases were defined as all subjects with at least 1 STI report following their initial enteric disease episode. A final logistic regression prediction model was chosen using forward stepwise selection. The prediction model with the greatest validity included age, sex, residential location, number of STI episodes experienced prior to the first enteric disease episode, type of enteric disease acquired, and an interaction term between age and male sex. This model had an area under the curve of 0.77 and had acceptable calibration. A coordinated public health response to the sexual transmission of enteric diseases requires that a distinction be made between cases of enteric diseases transmitted through sexual activity from those transmitted through contaminated food or water. A prediction model can aid public health officials in identifying individuals who may have a higher risk of sexually acquiring a reportable disease. Once identified, these individuals could receive specialized intervention to prevent future infection. The information produced from a prediction model capable of identifying higher risk individuals can be used to guide efforts in investigating and controlling reported cases of enteric diseases and STIs. © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A study of internet of things real-time data updating based on WebSocket

NASA Astrophysics Data System (ADS)

Wei, Shoulin; Yu, Konglin; Dai, Wei; Liang, Bo; Zhang, Xiaoli

2015-12-01

The Internet of Things (IoT) is gradually entering the industrial stage. Web applications in IoT such as monitoring, instant messaging, real-time quote system changes need to be transmitted in real-time mode to client without client constantly refreshing and sending the request. These applications often need to be as fast as possible and provide nearly real-time components. Real-time data updating is becoming the core part of application layer visualization technology in IoT. With support of data push in server-side, running state of "Things" in IoT could be displayed in real-time mode. This paper discusses several current real-time data updating method and explores the advantages and disadvantages of each method. We explore the use of WebSocket in a new approach for real-time data updating in IoT, since WebSocket provides low delay, low network throughput solutions for full-duplex communication.

AGRICULTURAL EDUCATION IN THE COMMUNITY COLLEGE.

ERIC Educational Resources Information Center

MCCOLLUM, EARL

RAPID CHANGE IN AGRICULTURE REQUIRES THAT TODAY'S AGRICULTURALIST BE A WELL-EDUCATED ARTICULATE TECHNICIAN. COMMUNITY COLLEGES CAN CONTRIBUTE THEIR GREATEST INFLUENCE ON THE FUTURE OF OUR SOCIETY AND NATION BY OFFERING SPECIALIZED AGRICULTURAL TECHNICIAN TRAINING FOR BOTH THOSE ENTERING THE FIELD AND THOSE WISHING TO UPDATE THEIR KNOWLEDGE AND…

Australasian neonatal intensive care enteral nutrition survey: implications for practice.

PubMed

Cormack, Barbara; Sinn, John; Lui, Kei; Tudehope, David

2013-04-01

This survey investigated standardised feeding guidelines and nutrition policy in Australasian neonatal intensive care units and compared these with previously published surveys and international consensus nutrition recommendations. An electronic survey on enteral nutrition comprising a wide range of questions about clinical practice was e-mailed to all 25 Australasian neonatal intensive care unit directors of tertiary perinatal centres. Twenty-five surveys were distributed; 24 (96%) were completed. All respondents preferred breast milk as the first feed. For infants <1000 g, 58% started feeds at 1 mL every 4 hours and 83% started enteral feeds on day 0-2 in the absence of contraindications. The identification of bile-stained gastric aspirates significant enough to withhold feeds varied. Multicomponent breast milk fortifiers were added by 58% when enteral feeds reached 150 mL/kg day, while 21% added these earlier at 120 mL/kg day or less. Iron supplementation was started at 4 weeks by 63% and at 6 weeks by 27%. Only 42% of units had a neonatal dietitian. Of the 24 units who responded, 58% had no written enteral feeding guidelines. Enteral nutrition was initiated earlier than in the past. Great variation remains in clinical practices. Nutritional implications are discussed. Standardisation of feeding guidelines and enteral nutrition policy based on current evidence and international consensus nutrition recommendations may be beneficial and should be encouraged. © 2012 The Authors. Journal of Paediatrics and Child Health © 2012 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Cognitive stimulation therapy as a sustainable intervention for dementia in sub-Saharan Africa: Feasibility and clinical efficacy using a stepped-wedge design - ERRATUM.

PubMed

Paddick, Stella-Maria; Mkenda, Sarah; Mbowe, Godfrey; Kisoli, Aloyce; Gray, William K; Dotchin, Catherine L; Ternent, Laura; Ogunniyi, Adesola; Kissima, John; Olakehinde, Olaide; Mushi, Declare; Walker, Richard W

2017-06-01

In the above article (Paddick, 2017) The corresponding author's details were previously listed incorrectly. The correct details are; contact number +44 191 293 2709 and email address William.gray@nhct.nhs.uk. The original article has been updated with the correct contact details. The publishers apologise for any inconvenience and confusion this error has caused.

Development of Medical Technology for Contingency Response to Marrow Toxic Agents

DTIC Science & Technology

2012-07-26

Confirmatory Testing DC Donor Center DIY Do it yourself DNA Deoxyribonucleic Acid DoD Department of Defense D/R Donor/Recipient EBMT European Group...recruitment support (Search screen redesign, New Donor Notes, HHQ enhancements, Site Maintenance redesign, Communications History, DIY ). National...Web and Do It Yourself ( DIY ) This project enables the ability to electronically contact the donors via email and allow them to update their contact

Cyberspace: Malevolent Actors, Criminal Opportunities, and Strategic Competition

DTIC Science & Technology

2016-08-01

Institute and U.S. Army War College Press publishes a monthly email newsletter to update the national security community on the research of our...program. Mr. Hutley is a highly seasoned information and communications technolo- gist (ICT) with 28 years in the telecommunications/ information ...the next decade. Prior to joining Cisco, Mr. Hutley was chief information officer for British Telecom’s Concert 670 Communications Company, a $1.5

Design and evaluation of a personal digital assistant–based alerting service for clinicians*†

PubMed Central

Johnson, E. Diane; Pancoast, Paul E.; Mitchell, Joyce A.; Shyu, Chi-Ren

2004-01-01

Purpose: This study describes the system architecture and user acceptance of a suite of programs that deliver information about newly updated library resources to clinicians' personal digital assistants (PDAs). Description: Participants received headlines delivered to their PDAs alerting them to new books, National Guideline Clearinghouse guidelines, Cochrane Reviews, and National Institutes of Health (NIH) Clinical Alerts, as well as updated content in UpToDate, Harrison's Online, Scientific American Medicine, and Clinical Evidence. Participants could request additional information for any of the headlines, and the information was delivered via email during their next synchronization. Participants completed a survey at the conclusion of the study to gauge their opinions about the service. Results/Outcome: Of the 816 headlines delivered to the 16 study participants' PDAs during the project, Scientific American Medicine generated the highest proportion of headline requests at 35%. Most users of the PDA Alerts software reported that they learned about new medical developments sooner than they otherwise would have, and half reported that they learned about developments that they would not have heard about at all. While some users liked the PDA platform for receiving headlines, it seemed that a Web database that allowed tailored searches and alerts could be configured to satisfy both PDA-oriented and email-oriented users. PMID:15494759

Reconsolidation May Incorporate State-Dependency into Previously Consolidated Memories

ERIC Educational Resources Information Center

Sierra, Rodrigo O.; Cassini, Lindsey F.; Santana, Fabiana; Crestani, Ana P.; Duran, Johanna M.; Haubrich, Josue; de Oliveira Alvares, Lucas; Quillfeldt, Jorge A.

2013-01-01

Some memories enter into a labile state after retrieval, requiring reconsolidation in order to persist. One functional role of memory reconsolidation is the updating of existing memories. There are reports suggesting that reconsolidation can be modulated by a particular endogenous process taking place concomitantly to its natural course, such as…

Investigating the Q invasion of Bemisia tabaci in Florida: Current status and update

USDA-ARS?s Scientific Manuscript database

Three separate Q haplotypes within Florida were discovered that could be used to associate populations known to be related by grower and plant type thereby tracking distribution routes. We determined that biotype Q entered Florida through at least two separate introductions. In-depth analysis of ins...

ENTRI HOME PAGE

Science.gov Websites

TREATY LOCATOR Treaty Locator Icon Select treaties based on search criteria. Browse results or construct updated August 2012 Metadata and suggested citations Collaborators and sponsors FAQs Search Treaty Texts Enter Keyword or Phrase: Search advanced search Search Conference of Party Decisions Search a complete

Laptop Program Update

ERIC Educational Resources Information Center

Levin, Howard

2006-01-01

Students entering Steve Speier's Spanish class pull their personal laptops from their packs and begin preparing for the lesson. Some review Speier's board notes containing a combination of typed phrases and dozens of handdrawn vocabulary words saved as PDF files from his interactive white board Notebook program. Others don headphones and listen to…

Wikis and Collaborative Inquiry

ERIC Educational Resources Information Center

Lamb, Annette; Johnson, Larry

2009-01-01

Wikis are simply Web sites that provide easy-to-use tools for creating, editing, and sharing digital documents, images, and media files. Multiple participants can enter, submit, manage, and update a single Web workspace creating a community of authors and editors. Wiki projects help young people shift from being "consumers" of the Internet to…

Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN.

PubMed

Wahlgren, Nils; Moreira, Tiago; Michel, Patrik; Steiner, Thorsten; Jansen, Olav; Cognard, Christophe; Mattle, Heinrich P; van Zwam, Wim; Holmin, Staffan; Tatlisumak, Turgut; Petersson, Jesper; Caso, Valeria; Hacke, Werner; Mazighi, Mikael; Arnold, Marcel; Fischer, Urs; Szikora, Istvan; Pierot, Laurent; Fiehler, Jens; Gralla, Jan; Fazekas, Franz; Lees, Kennedy R

2016-01-01

The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16-18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then been approved by each society. The recommendations are identical to the original version with evidence level upgraded by 20 February 2015 and confirmed by 15 May 2015. The purpose of the ESO-Karolinska Stroke Update meetings is to provide updates on recent stroke therapy research and to discuss how the results may be implemented into clinical routine. Selected topics are discussed at consensus sessions, for which a consensus statement is prepared and discussed by the participants at the meeting. The statements are advisory to the ESO guidelines committee. This consensus statement includes recommendations on mechanical thrombectomy after acute stroke. The statement is supported by ESO, European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), and European Academy of Neurology (EAN). © 2016 World Stroke Organization.

User interface to administrative DRMS within a distributed environment

NASA Technical Reports Server (NTRS)

Martin, L. D.; Kirk, R. D.

1983-01-01

The implementation of a data base management system (DBMS) into a communications office to control and report on communication leased service contracts is discussed. The system user executes online programs to update five files residing on a UNIVAC 1100/82, through the forms mode features of the Tektronix 4025 terminal and IMSAI 8080 microcomputer. This user can select the appropriate form to the Tektronix 4025 screen, and enter new data, update existing data, or discontinue service. Selective online printing of 40 reports is accomplished by the system user to satisfy management, budget, and bill payment reporting requirements.

The value of internship in graduate medical education: survey of emergency medicine residents and program directors.

PubMed

Ray, Adam M

2007-01-01

To assess the opinions of emergency medicine (EM) residents and program directors about the value of completing a nonrequired 1-year internship before entering an EM residency program accredited by the Accreditation Council for Graduate Medical Education (ACGME). An eight-question, self-administered online survey was e-mailed to EM residents who had completed a nonrequired internship before entering ACGME-accredited residency programs. A separate, six-question survey was e-mailed to program directors of ACGME-accredited programs that do not require an internship who had ever had a resident who had completed a nonrequired internship. Forty-six (27 [59%] osteopathic, 19 [41%] allopathic) of 113 residents and 40 of 124 program directors responded to the survey questions. Less than 4% of residents completed a separate nonrequired 1-year internship. The most common reason for completing a nonrequired internship was to obtain licensure by the American Osteopathic Association (19 [41%]). Most residents believed that they were more proficient with history-taking and physical examinations (38 [83%]) and procedures (34 [74%]) during the first year of residency than their colleagues who did not complete an internship, but this percentage decreased over time. The program directors had similar opinions. Most osteopathic residents who completed the internship for osteopathic licensure would not have done so if it were not required. Most (39 of 40) program directors would not recommend taking a nonrequired internship. Completing a 1-year internship before entering an EM residency program may better prepare physicians for their first year of residency in terms of basic clinical competancy, but further study is needed in this area.

A brief qualitative survey on the utilization of Yoga research resources by Yoga teachers.

PubMed

Bhavanani, Ananda Balayogi

2016-01-01

Yoga has become popular worldwide with increasing research done on its therapeutic potential. However, it remains to be determined whether such findings actually percolate down into teaching and practice of Yoga teachers/therapists. The aim of this survey was to document awareness of Yoga research findings in the Yoga community and find out how these were utilized. It was undertaken with a select group of 34 international Yoga teachers and therapists utilizing email and social media between August and December 2015. Majority of responders had well-established reputation in Yoga and were from diverse lineages with 30 of them having more than 5 years of experience in the field. A set of eight questions were sent to them related to essentiality of Yoga research, how they updated themselves on research findings and whether such studies influenced their teaching and practice. Responses were compiled and appropriate statistics determined for quantitative aspects while feedback, comments and suggestions were noted in detail. About 89% agreed that it was essential to be up-to-date on Yoga research but only 70% updated themselves regularly with average papers read fully per year being <10. Most accessed information through general news reports, emails from contacts, and articles on internet sites whereas only 7% were through PubMed. About 60% felt these studies helped them in general teaching whereas 20% said that such studies had not really influenced it in any way. This survey provides a basic picture of a general lack of awareness of Yoga research amongst practicing Yoga teachers and therapists. Though a majority agree research is important, few seriously update themselves on this through scientific channels. With regard to future studies, most wanted "proof" that could be used to convince potential clients and felt that more qualitative methods should be applied.

Enumeration and extension of non-equivalent deterministic update schedules in Boolean networks.

PubMed

Palma, Eduardo; Salinas, Lilian; Aracena, Julio

2016-03-01

Boolean networks (BNs) are commonly used to model genetic regulatory networks (GRNs). Due to the sensibility of the dynamical behavior to changes in the updating scheme (order in which the nodes of a network update their state values), it is increasingly common to use different updating rules in the modeling of GRNs to better capture an observed biological phenomenon and thus to obtain more realistic models.In Aracena et al. equivalence classes of deterministic update schedules in BNs, that yield exactly the same dynamical behavior of the network, were defined according to a certain label function on the arcs of the interaction digraph defined for each scheme. Thus, the interaction digraph so labeled (update digraphs) encode the non-equivalent schemes. We address the problem of enumerating all non-equivalent deterministic update schedules of a given BN. First, we show that it is an intractable problem in general. To solve it, we first construct an algorithm that determines the set of update digraphs of a BN. For that, we use divide and conquer methodology based on the structural characteristics of the interaction digraph. Next, for each update digraph we determine a scheme associated. This algorithm also works in the case where there is a partial knowledge about the relative order of the updating of the states of the nodes. We exhibit some examples of how the algorithm works on some GRNs published in the literature. An executable file of the UpdateLabel algorithm made in Java and the files with the outputs of the algorithms used with the GRNs are available at: www.inf.udec.cl/ ∼lilian/UDE/ CONTACT: lilisalinas@udec.cl Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Update: Transitional Bilingual Instruction Program (TBIP) 2012-2013

ERIC Educational Resources Information Center

Malagon, Helen; McCold, Paul; Nelson, Joan Johnston

2013-01-01

When students with little or no previous exposure to the English language enter schools in Washington, they are often unable to fully benefit from content instruction provided in English. They are at a high risk of academic failure unless the necessary language support is provided. The Transitional Bilingual Instruction Program (TBIP) provides…

IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR 1,1,1-TRICHLOROETHANE (PEER REVIEW PLAN)

EPA Science Inventory

EPA's assessment of the carcinogenic potential of 1,1,1-trichloroethane was entered into the IRIS database in 1988, and the assessment of noncancer effects following oral exposure was withdrawn from IRIS in 1991. The IRIS program prepared an update of the IRIS assessment for 1,1,...

Building a commercial enterprise : FY01-05 financial plan update : investing in the future of passenger rail : long-term capital plan

DOT National Transportation Integrated Search

2001-01-01

As we enter the 21st century, the nations transportation system is at a crossroads. After : building highway and aviation networks that are the envy of the world, increasing gridlock threatens to undermine the success of those investments and the ...

Psychosocial Interventions for Children and Adolescents in Foster Care: Review of Research Literature

ERIC Educational Resources Information Center

Landsverk, John A.; Burns, Barbara J.; Stambaugh, Leyla Faw; Rolls Reutz, Jennifer A.

2009-01-01

Between one-half and three-fourths of children entering foster care exhibit behavioral or social-emotional problems warranting mental health care. This paper, condensed and updated from a technical report prepared for Casey Family Programs in 2005, reviews evidence-based and promising interventions for the most prevalent mental conditions found…

The U.S. EPA ToxCast Program: Moving from Data Generation to Application (SOT Tox21 update symposium presentation)

EPA Science Inventory

The U.S. EPA ToxCast program is entering its tenth year. Significant learning and progress have occurred towards collection, analysis, and interpretation of the data. The library of ~1,800 chemicals has been subject to ongoing characterization (e.g., identity, purity, stability...

75 FR 5902 - Guarantees for Bonds and Notes Issued for Electrification or Telephone Purposes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

... electric and telephone purposes. These proposed amendments implement changes adapted in the Food, Conservation, and Energy Act of 2008. The intended effect is to update agency regulations to reflect current...: Go to http://www.regulations.gov . In the ``Search Documents'' box, enter RUS-09- Electric-0005...

Updated standards and processes for accreditation of echocardiographic laboratories from The European Association of Cardiovascular Imaging.

PubMed

Popescu, Bogdan A; Stefanidis, Alexandros; Nihoyannopoulos, Petros; Fox, Kevin F; Ray, Simon; Cardim, Nuno; Rigo, Fausto; Badano, Luigi P; Fraser, Alan G; Pinto, Fausto; Zamorano, Jose Luis; Habib, Gilbert; Maurer, Gerald; Lancellotti, Patrizio; Andrade, Maria Joao; Donal, Erwan; Edvardsen, Thor; Varga, Albert

2014-07-01

Standards for echocardiographic laboratories were proposed by the European Association of Echocardiography (now the European Association of Cardiovascular Imaging) 7 years ago in order to raise standards of practice and improve the quality of care. Criteria and requirements were published at that time for transthoracic, transoesophageal, and stress echocardiography. This paper reassesses and updates the quality standards to take account of experience and the technical developments of modern echocardiographic practice. It also discusses quality control, the incentives for laboratories to apply for accreditation, the reaccreditation criteria, and the current status and future prospects of the laboratory accreditation process. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

The updating of clinical practice guidelines: insights from an international survey

PubMed Central

2011-01-01

Background Clinical practice guidelines (CPGs) have become increasingly popular, and the methodology to develop guidelines has evolved enormously. However, little attention has been given to the updating process, in contrast to the appraisal of the available literature. We conducted an international survey to identify current practices in CPG updating and explored the need to standardize and improve the methods. Methods We developed a questionnaire (28 items) based on a review of the existing literature about guideline updating and expert comments. We carried out the survey between March and July 2009, and it was sent by email to 106 institutions: 69 members of the Guidelines International Network who declared that they developed CPGs; 30 institutions included in the U.S. National Guideline Clearinghouse database that published more than 20 CPGs; and 7 institutions selected by an expert committee. Results Forty-four institutions answered the questionnaire (42% response rate). In the final analysis, 39 completed questionnaires were included. Thirty-six institutions (92%) reported that they update their guidelines. Thirty-one institutions (86%) have a formal procedure for updating their guidelines, and 19 (53%) have a formal procedure for deciding when a guideline becomes out of date. Institutions describe the process as moderately rigorous (36%) or acknowledge that it could certainly be more rigorous (36%). Twenty-two institutions (61%) alert guideline users on their website when a guideline is older than three to five years or when there is a risk of being outdated. Twenty-five institutions (64%) support the concept of "living guidelines," which are continuously monitored and updated. Eighteen institutions (46%) have plans to design a protocol to improve their guideline-updating process, and 21 (54%) are willing to share resources with other organizations. Conclusions Our study is the first to describe the process of updating CPGs among prominent guideline institutions across the world, providing a comprehensive picture of guideline updating. There is an urgent need to develop rigorous international standards for this process and to minimize duplication of effort internationally. PMID:21914177

The Struggle for Yemen and the Challenge of Al-Qaeda in the Arabian Peninsula

DTIC Science & Technology

2013-06-01

topics having strategic implications for the Army, the Department of Defense, and the larger national security community . In addition to its studies, SSI...www.StrategicStudiesInstitute.army.mil. ***** The Strategic Studies Institute and USAWC Press publishes a monthly e-mail newsletter to update the national security community on the...factions for over a year beginning in early 2011. This prolonged crisis prevented Yemen’s government, under President Ali Abdullah Saleh, from doing

Disjointed Ways, Disunified Means: Learning From America’s Struggle to Build an Afghan Nation

DTIC Science & Technology

2012-05-01

unify- ing the intelligence community with a new National Intelligence Director, and creating a network-based information -sharing system. The...no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control... a monthly e-mail newsletter to update the national security community on the re- search of our analysts, recent and forthcoming publications, and

Models of Government Blogging: Design Tradeoffs in Civic Engagement

NASA Astrophysics Data System (ADS)

Kavanaugh, Andrea; Kim, Hyung Nam; Pérez-Quiñones, Manuel; Isenhour, Philip

Some local government officials and staff have been experimenting with emerging technologies as part of a broad suite of media used for informing and communicating with their constituencies. In addition to the typical government website and, for some, email exchange with citizens, some town and municipal governments are using blogs, video streaming, pod- casting, and Real Simple Syndication (RSS) to reach constituencies with updates and, in some cases, interaction and discussion between citizens and government.

Colombia: Updating the Mission

DTIC Science & Technology

2011-09-01

consequences of that are all too appar- ent. We must now learn to govern ourselves more intelligently. The first step is to accept that, in a complex universe...anticipatory governance first came to the author’s attention when it was used in an email written by former student Neil Padukone. The term also appears to have...3 The Chief Operating Officer as mandated by the Government Performance and Results Modernization Act (2011) could be a model or used as a

Digital ureteroscopes: technology update

PubMed Central

Gridley, Chad M; Knudsen, Bodo E

2017-01-01

The field of ureteroscopy has undergone a continual evolution since the first ureteroscopes were introduced. Over the past 10 years, we have entered into the digital era of ureteroscopy with both semirigid and flexible options becoming available. The following review looks at the benefits and drawbacks of digital flexible ureteroscopes as well as the current commercially available options. PMID:28203551

Update: Report on Innovations in Developmental Mathematics--Moving Mathematical Graveyards

ERIC Educational Resources Information Center

Merseth, Katherine K.

2011-01-01

Every year tens of thousands of students step foot on community college campuses, many for the first time. These students all have one thing in common: hope. They enter these institutions with lofty goals and a fervent expectation that the educative experience they are about to embark upon will fundamentally improve their lives. Yet, their hopes…

77 FR 48524 - Board of Scientific Counselors, National Center for Health Statistics; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-14

... Regulations, Title 41, Code of Federal Regulation, Subpart 101-20.301, all persons entering in or on Federal...; update on the National survey of Family Growth; the initiation of the review of the Office of Research... the presenter. Written comments should not exceed five single-spaced typed pages in length and must be...

Tellurate enters Escherichia coli K-12 cells via the SulT-type sulfate transporter CysPUWA.

PubMed

Goff, Jennifer; Yee, Nathan

2017-12-29

Soluble forms of tellurium are environmental contaminants that are toxic to microorganisms. While tellurite [Te(IV)] is a well-characterized antimicrobial agent, little is known about the interactions of tellurate [Te(VI)] with bacterial cells. In this study, we investigated the role of sulfate transporters in the uptake of tellurate in Escherichia coli K-12. Mutant strains carrying a deletion of the cysW gene in the CysPUWA sulfate transporter system accumulated less cellular tellurium and exhibited higher resistance to tellurate compared with the wild-type strain. Complementation of the mutation restored tellurate sensitivity and uptake. These results indicate that tellurate enters E. coli cells to cause toxic effects via the CysPUWA sulfate transporter. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Communicating with Biobank Participants: Preferences for Receiving and Providing Updates to Researchers

PubMed Central

Mester, Jessica L.; Mercer, MaryBeth; Goldenberg, Aaron; Moore, Rebekah A.; Eng, Charis; Sharp, Richard R.

2015-01-01

Background Research biobanks collect biological samples and health information. Previous work shows that biobank participants desire general study updates, but preferences regarding the method or frequency of these communications have not been explored. Thus, we surveyed participants in a long-standing research biobank. Methods Eligible participants were drawn from a study of patients with personal/family history suggestive of Cowden syndrome, a poorly-recognized inherited cancer syndrome. Participants gave blood samples and access to medical records and received individual results but had no other study interactions. The biobank had 3618 participants at sampling. Survey eligibility included age ≥18 years, enrollment within the biobank’s first five years, normal PTEN analysis, and contiguous United States address. Multivariate logistic regression analyses identified predictors of participant interest in internet-based vs. offline methods and methods allowing participant-researcher interaction vs. one-way communication. Independent variables were narrowed by independent Pearson correlations by cutoff p<0.2, with p<0.02 considered significant. Results Surveys were returned from 840/1267 (66%) eligible subjects. Most (97%) wanted study updates with 92% wanting updates at least once a year. Participants preferred paper (66%) or emailed (62%) newsletter methods with 95% selecting one of these. Older, less-educated, and lower-income respondents strongly preferred offline approaches (p<0.001). Most (93%) had no concerns about receiving updates and 97% were willing to provide health updates to researchers. Conclusion Most participants were comfortable receiving and providing updated information. Demographic factors predicted communication preferences. Impact Researchers should make plans for ongoing communication early in study development and funders should support the necessary infrastructure for these efforts. PMID:25597748

Comprehensive restriction enzyme lists to update any DNA sequence computer program.

PubMed

Raschke, E

1993-04-01

Restriction enzyme lists are presented for the practical working geneticist to update any DNA computer program. These lists combine formerly scattered information and contain all presently known restriction enzymes with a unique recognition sequence, a cut site, or methylation (in)sensitivity. The lists are in the shortest possible form to also be functional with small DNA computer programs, and will produce clear restriction maps without any redundancy or loss of information. The lists discern between commercial and noncommercial enzymes, and prototype enzymes and different isoschizomers are cross-referenced. Differences in general methylation sensitivities and (in)sensitivities against Dam and Dcm methylases of Escherichia coli are indicated. Commercial methylases and intron-encoded endonucleases are included. An address list is presented to contact commercial suppliers. The lists are constantly updated and available in electronic form as pure US ASCII files, and in formats for the DNA computer programs DNA-Strider for Apple Macintosh, and DNAsis for IBM personal computers or compatibles via e-mail from the internet address: NETSERV@EMBL-HEIDELBERG.DE by sending only the message HELP RELIBRARY.

Continuously updated network meta-analysis and statistical monitoring for timely decision-making

PubMed Central

Nikolakopoulou, Adriani; Mavridis, Dimitris; Egger, Matthias; Salanti, Georgia

2016-01-01

Pairwise and network meta-analysis (NMA) are traditionally used retrospectively to assess existing evidence. However, the current evidence often undergoes several updates as new studies become available. In each update recommendations about the conclusiveness of the evidence and the need of future studies need to be made. In the context of prospective meta-analysis future studies are planned as part of the accumulation of the evidence. In this setting, multiple testing issues need to be taken into account when the meta-analysis results are interpreted. We extend ideas of sequential monitoring of meta-analysis to provide a methodological framework for updating NMAs. Based on the z-score for each network estimate (the ratio of effect size to its standard error) and the respective information gained after each study enters NMA we construct efficacy and futility stopping boundaries. A NMA treatment effect is considered conclusive when it crosses an appended stopping boundary. The methods are illustrated using a recently published NMA where we show that evidence about a particular comparison can become conclusive via indirect evidence even if no further trials address this comparison. PMID:27587588

Update on the Status of Bemisia tabaci in the UK and the Use of Entomopathogenic Fungi within Eradication Programmes

PubMed Central

Cuthbertson, Andrew G. S.

2013-01-01

The sweetpotato whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) continues to be a serious threat to crops worldwide. The UK holds Protected Zone status against this pest and, as a result, B. tabaci entering on plant material is subjected to a policy of eradication. Both B and Q Bemisia biotypes are now regularly intercepted entering the UK. With increasing reports of neonicotinoid resistance in both these biotypes, it is becoming more problematic to control/eradicate. Therefore, alternative means of control are necessary. Entomopathogenic fungi (Lecanicilllium muscarium and Beauveria bassiana) offer much potential as control agents of B. tabaci within eradication programmes in the UK. PMID:26464385

National Study of Student Support Services. Third-Year Longitudinal Study Results and Program Implementation Study Update.

ERIC Educational Resources Information Center

Chaney, Bradford; Muraskin, Lana; Cahalan, Margaret; Rak, Rebecca

This follow-up study, part of the National Study of Student Support Services compared the status of 2,900 disadvantaged students receiving student support services (SSS) since entering college 3 years earlier and 2,900 nonparticipating comparable students. Services offered varied among institutions but were all intended to help students stay in…

New Technology Tools: Using Social Media for Alcohol, Drug Abuse, and Violence Prevention. Prevention Update

ERIC Educational Resources Information Center

Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2011

2011-01-01

When it comes to using social media technology for alcohol, drug abuse, and violence prevention, Thomas Workman, at Baylor College of Medicine's John M. Eisenberg Center for Clinical Decisions and Communications Science, points out that social media is interactive. This means that a person is entering a conversation rather than a declaration, and…

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5 ...

EPA Pesticide Factsheets

The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the RDX assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for RDX. The outcome of this project is an updated Toxicological Review and IRIS Summary for RDX that will be entered into the IRIS database.

Using Computers in Introductory Astronomy Courses

NASA Astrophysics Data System (ADS)

Deming, Grace L.

1995-12-01

Computer literacy is fast becoming a focal point in undergraduate education. Scientific literacy has been a continuing goal of undergraduate programs across the nation and a course in introductory astronomy is often used to satisfy such science requirements. At U. MD an introduction to computer skills is being integrated into our astronomy curriculum for non-science majors. The campus is adequately equipped with computer labs, yet many students enter college without basic computer skills. In Astronomy 101 (General Astronomy) students are introduced to electronic mail, a Listserver, and the world wide web. Students in this course are required to register for a free campus computer account. Their first assignment is to use e-mail to subscribe to the class Listserver, Milkyway. Through Milkyway, students have access to weekly lecture summaries, questions to review for exams, and copies of previous exams. Using e-mail students may pose questions, provide comments, or exchange opinions using Milkyway, or they may e-mail the instructor directly. Studies indicate that using e-mail is less intimidating to a student than asking a question in a class of 200 students. Monitoring e-mail for student questions has not been a problem. Student reaction has been favorable to using e-mail, since instructor office hours are not always convenient, especially to commuting or working students. Through required assignments, students receive an introduction to accessing information on the world wide web using Netscape. Astronomy has great resources available on the Internet which can be used to supplement and reinforce introductory material. Assignments are structured so that students will gain the techniques necessary to access available information. It is hoped that students will successfully apply the computer skills they learn in astronomy class to their own fields and as life-long learners. We have found that students comfortable with computers are willing to share their knowledge with others. The computer activities have been structured to promote cooperation between students. These skills are also necessary for success.

Electronic patient-reported outcomes from home in patients recovering from major gynecologic cancer surgery: A prospective study measuring symptoms and health-related quality of life.

PubMed

Cowan, Renee A; Suidan, Rudy S; Andikyan, Vaagn; Rezk, Youssef A; Einstein, M Heather; Chang, Kaity; Carter, Jeanne; Zivanovic, Oliver; Jewell, Elizabeth J; Abu-Rustum, Nadeem R; Basch, Ethan; Chi, Dennis S

2016-11-01

We previously reported on the feasibility of a Web-based system to capture patient-reported outcomes (PROs) in the immediate postoperative period. The purpose of this study was to update the experience of these patients and assess patient and provider satisfaction and feedback regarding the system. This is a prospective cohort study of patients scheduled to undergo laparotomy for presumed gynecologic malignancy. Patients completed a Web-based Symptom Tracking and Reporting (STAR) questionnaire preoperatively and weekly during a 6-week postoperative period. Email alerts were sent to study nurses when concerning patient responses were entered. The patient and the nurse assessments of STAR's usefulness were measured via an exit survey. The study enrolled 96 eligible patients. Of these, 71 patients (74%) completed at least four of seven total sessions. Of the patients who completed the exit satisfaction survey, 98% found STAR easy to use; 84% found it useful; and 82% would recommend it to other patients. Despite positive feedback from patients, clinical personnel found that the STAR system increased their current workload without enhancing patient care. Application of an electronic program for PROs in those recovering from major gynecologic cancer surgery is feasible, and acceptable to most patients. While most clinicians did not find STAR clinically helpful, the majority of patients reported a positive experience with the system and would recommend its use. The program helped many patients feel more empowered in their postoperative recovery. Copyright © 2016 Elsevier Inc. All rights reserved.

Collaboration of the Joint Research Centre and the European Customs laboratories for Identification of New Psychoactive Substances.

PubMed

Guillou, Claude; Reniero, Fabiano; Vicente, Joana Lobo Pereira; Holland, Margaret; Kolar, Kamil; Chassaigne, Hubert; Tirendi, Salvatore; Schepers, Herve

2018-05-23

The emergence of designer drugs as substances of abuse has seen a dramatic increase over the last few years. Customs officials are responsible for the control of products entering the European Union (EU) market. This control applies to chemicals in general, pharmaceutical products and medicines. Numerous products imported from non-EU countries, often -declared as 'bath salts' or 'fertilizers', may in fact contain new psychoactive substance (NPS). These are not necessarily controlled under international law, but are subject to monitoring in agreement with EU legislation. This situation imposes many challenges for the maintenance of updated spectral libraries used for their detection by control laboratories. The chemical identification of new substances, with the use of powerful instrumentation, and the time needed for detailed analysis and interpretation of the results, demands a considerable scientific commitment. The Joint Research Centre endeavors to provide this through its scientific support to the EU Customs laboratories to facilitate the rapid identification and characterisation of seized samples. Apart from the known NPS, several new chemical substances have also been identified. Those belonging to known NPS families have already been notified to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). The aim of this paper is to discuss the implementation of the workflow mechanism, regarding the harmonisation of procedures to facilitate the monitoring, communication and management of analytical data. The rapid dissemination of this information between control authorities would facilitate the protection of EU citizens against the health risks posed by harmful substances. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Evaluating Evidence-Based Nutrition Support Practice Among Healthcare Professionals With and Without the Certified Nutrition Support Clinician Credential.

PubMed

Brody, Rebecca; Hise, Mary; Marcus, Andrea Fleisch; Harvey-Banchik, Lillian; Matarese, Laura E

2016-01-01

The National Board of Nutrition Support Certification credentials healthcare professionals and certifies that holders of the Certified Nutrition Support Clinician (CNSC) credential have specialized knowledge of safe and effective nutrition support therapy. The purpose of this pilot study was to survey healthcare professionals affiliated with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) regarding their approaches to nutrition support practice using a complex patient case scenario in accordance with established clinical guidelines. An electronic survey was emailed to individuals affiliated with A.S.P.E.N. Eight multiple-choice knowledge questions addressed evidence-based nutrition support practice issues for a patient with progressing pancreatitis. Demographic and clinical characteristic data were collected. Of 48,093 email invitations sent, 4455 (9.1%) responded and met inclusion criteria. Most respondents were dietitians (70.8%) and in nutrition support practice for 10.3 years, and 29.3% held the CNSC credential. Respondents with the CNSC credential answered 6.18 questions correctly compared with 4.56 for non-CNSC respondents (P < .001). For all 8 questions, CNSC respondents were significantly more likely to choose the correct answer compared with non-CNSC respondents (P < .001). Professionals with the CNSC credential scored significantly higher on a complex case-based knowledge assessment of guideline recommendations for the nutrition support treatment of pancreatitis compared with those without a credential. © 2015 American Society for Parenteral and Enteral Nutrition.

[Three years of vertical networking in the German Network of Competence on Viral Hepatitis: what can we learn from the usage of different information tools?].

PubMed

Meyer, S; Manns, M P; Wedemeyer, H

2006-01-01

Treatment of patients with viral hepatitis is time-consuming and sometimes complicated. Several sources of information have been established as internet sites, however systematic analyses of the need and use of these information platforms are lacking. The Competence Network on Viral Hepatitis (Hep-Net) was established in 2002 and offers a telephone hotline, an e-mail service and a home page with frequently asked questions (FAQs). On the internet pages "FAQs" 38 125 hits have been registered on single "question-answer-units" within three years. In a half of the cases the question are associated with modes of transmission. In contrast, patient's questions in e-mail and the telephone hotline are mainly dealing with the treatment of hepatitis C. More than 46 % of the physician's questions referred to unclearness in indications for treatment. Questions on specific medical problems of individual patients and, in e-mail, also on legal issues played a major part. Many of these questions have not been addressed in the actual guidelines in Germany. In summary, the Hep-Net vertical networking tools represent a fast, quality-assured endorsement to the daily management of patients with viral hepatitis. The combination of internet, e-mail service and telephone hotline gives consideration to individual necessities of patients and physicians. However, the detailed analysis of usage also shows limitations of current guidelines which should be considered during updating.

Promoting Engagement With a Digital Health Intervention (HeLP-Diabetes) Using Email and Text Message Prompts: Mixed-Methods Study

PubMed Central

Modrow, Kerstin; Hamilton, Fiona; Pal, Kingshuk; Ross, Jamie

2017-01-01

Background Engagement with digital health interventions (DHIs) may be regarded as a prerequisite for the intervention to achieve positive health or behavior change outcomes. One method employed to promote engagement is the use of prompts such as emails and text messages. However, little is known about the characteristics of prompts that promote engagement. This study explored the association between the content and delivery mode of prompts and the users’ engagement with HeLP-Diabetes (Healthy Living for People with type 2 Diabetes), a DHI that aimed to promote self-management in adults with type 2 diabetes. Objective The objective of this study was to identify the characteristics of prompts, specifically the content and delivery mode, which were associated with increased engagement. Methods This was a mixed-methods study. Email and text message prompts were sent to the registered users of HeLP-Diabetes. Use of the intervention was recorded and examined to identify which email and text message prompts were associated with subsequent visits to the DHI. Characteristics of prompts that were identified as particularly effective or ineffective were explored through think-aloud interviews with the participants. Results Of a total of 39 email prompts, 49% (19/39) prompts showed a significant association with subsequent visits to the DHI. However, none of the text message prompts were associated with subsequent visits to the DHI. Furthermore, think-aloud interviews were carried out with 6 experienced participants with type 2 diabetes. The findings suggest that these participants preferred email prompts that were clear, relatively short, and empowering; used nondirective advice; included health professional references; were visually appealing; and contained news and updates. Conclusions The findings of this study contribute to the existing evidence supporting the role of email prompts in promoting and maintaining engagement with DHIs. This study described the content of prompts that may be engaging. However, the results should be interpreted with caution, as prompts may be context-specific interventions and the results may not be generalizable across other DHIs or other types of interventions targeting self-management of type 2 diabetes. PMID:28829328

GOC-TX: A Reliable Ticket Synchronization Application for the Open Science Grid

NASA Astrophysics Data System (ADS)

Hayashi, Soichi; Gopu, Arvind; Quick, Robert

2011-12-01

One of the major operational issues faced by large multi-institutional collaborations is permitting its users and support staff to use their native ticket tracking environment while also exchanging these tickets with collaborators. After several failed attempts at email-parser based ticket exchanges, the OSG Operations Group has designed a comprehensive ticket synchronizing application. The GOC-TX application uses web-service interfaces offered by various commercial, open source and other homegrown ticketing systems, to synchronize tickets between two or more of these systems. GOC-TX operates independently from any ticketing system. It can be triggered by one ticketing system via email, active messaging, or a web-services call to check for current sync-status, pull applicable recent updates since prior synchronizations to the source ticket, and apply the updates to a destination ticket. The currently deployed production version of GOC-TX is able to synchronize tickets between the Numara Footprints ticketing system used by the OSG and the following systems: European Grid Initiative's system Global Grid User Support (GGUS) and the Request Tracker (RT) system used by Brookhaven. Additional interfaces to the BMC Remedy system used by Fermilab, and to other instances of RT used by other OSG partners, are expected to be completed in summer 2010. A fully configurable open source version is expected to be made available by early autumn 2010. This paper will cover the structure of the GOC-TX application, its evolution, and the problems encountered by OSG Operations group with ticket exchange within the OSG Collaboration.

Continuous subcutaneous levetiracetam in the management of seizures at the end of life: a case report.

PubMed

Wells, Geoffrey Howard; Mason, Louise D; Foreman, Emma; Chambers, John

2016-03-01

We report the case of a man who developed seizures on a background of recurrent metastatic squamous cell carcinoma with intracranial involvement. Initial seizure control with enteral levetiracetam was achieved, and when enteral and intravenous (i.v.) access was no longer available, a continuous subcutaneous infusion (CSCI) of levetiracetam successfully controlled his seizures without the need for sedating anticonvulsants. As a result, end-of-life care was able to be given with the patient retaining the ability to communicate with his family and healthcare staff. This report adds to the sparse but growing evidence base for the use of subcutaneous levetiracetam to manage seizures in palliative and end-of-life care. © The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

EMB6/481: Evidence-Based Patient Education on the Web: Methods and studies for determining consumers' needs

PubMed Central

Eysenbach, G; Fartasch, D; Diepgen, TL

1999-01-01

Introduction On the Internet, thousands of medical Web sites aim to educate consumers in the field of health. The quality of the educational material for patients varies greatly and is rarely "evidence-based" - not only in terms of the scientific accuracy but also in terms of sometimes questionable appropriateness for the target group. Material boring the reader with facts already known to him/her and failing to address common questions or misunderstandings will most likely fail to reach its aims. Conventional studies to determine the information needs of patients and their relatives are expensive and difficult to conduct. At our dermatology portal site we conducted two separate studies using two different approaches to determine the "needs" of the consumers by using both most commonly used "feedback channels" the Internet has to offer: Emails and Web forms. Methods In the first study, we systematically reviewed 209 unsolicited emails we received from consumers in response to our dermatology Web site, analyzing their contents in respect to previous contacts with live physicians, disease duration, level of frustration expressed in the e-mails, and type of information sought. In another study, we developed a web-based questionnaire as a "pre-test" to determine the knowledge level of patients visiting a patient education site on atopic eczema. The "pre-test" is a form-based "quiz", users are asked to voluntarily complete this questionnaire before entering the information system. The quiz contains 24 statements about atopic eczema, which the user should mark as "true" or "untrue". Once completed, answers are stored in a database and the system generates a dynamic, customized page for the user with explanations and hyperlinks to the respective Web pages which contain further information about the respective items. Results Analysis of the 209 emails revealed that many dermatologic patients surfing the Internet and requesting tele-advice have a chronic disease (81%) and seek a second opinion. Seventeen percent express frustration about previous encounters with live physicians. 40% of all e-mails could have been answered by a librarian. In at least 5 instances patients attempt self-diagnosis. Analysis of 1010 responses to the quiz, entered within 5 months (27.2.-27.7.98), revealed some common misunderstandings among patients with atopic eczema, for example that it is a psychosomatic disease or "disease of the nerves", that a special diet is principally required and that AE is an allergy (which is an especially common misunderstanding among parents!). Discussion The studies demonstrate how easy, fast and cost-effectively the information needs of patients and consumers can be determined using interactive venues on the Internet and give some insights into the motivation of consumers to consult the Internet.

Tracking with time-delayed data in multisensor systems

NASA Astrophysics Data System (ADS)

Hilton, Richard D.; Martin, David A.; Blair, William D.

1993-08-01

When techniques for target tracking are expanded to make use of multiple sensors in a multiplatform system, the possibility of time delayed data becomes a reality. When a discrete-time Kalman filter is applied and some of the data entering the filter are delayed, proper processing of these late data is a necessity for obtaining an optimal estimate of a target's state. If this problem is not given special care, the quality of the state estimates can be degraded relative to that quality provided by a single sensor. A negative-time update technique is developed using the criteria of minimum mean-square error (MMSE) under the constraint that only the results of the most recent update are saved. The performance of the MMSE technique is compared to that of the ad hoc approach employed in the Cooperative Engagement Capabilities (CEC) system for processing data from multiple platforms. It was discovered that the MMSE technique is a stable solution to the negative-time update problem, while the CEC technique was found to be less than desirable when used with filters designed for tracking highly maneuvering targets at relatively low data rates. The MMSE negative-time update technique was found to be a superior alternative to the existing CEC negative-time update technique.

Novel ways of improving communication with members of health professional associations.

PubMed

Chaudhary, Pushpa; Tuladhar, Heera

2014-10-01

The International Federation of Gynecology and Obstetrics (FIGO) supported the Nepal Society of Obstetricians and Gynaecologists (NESOG) to help influence national health policy and practice through FIGO's Leadership in Obstetrics and Gynecology for Impact and Change (LOGIC) Initiative in Maternal and Newborn Health. An Organizational Capacity Improvement Framework, developed by the Society of Obstetricians and Gynaecologists of Canada (SOGC), was used to evaluate NESOG's initial baseline organizational capacity in 2010. Communication among NESOG members was rated as moderate (39%). Several initiatives, such as the use of high-speed internet access, group SMS texts and emails for information sharing, member profile updates, use of social media, and regular updates to the NESOG website were examples of interventions that resulted in improved participation of members in NESOG's activities. Members were impressively active in reciprocating via Facebook, and via participation in online voting in the NESOG elections (84%). Copyright © 2014. Published by Elsevier Ireland Ltd.

Update on chronic complex patient malnutrition

PubMed

Álvarez Hernández, Julia

2017-05-08

The Scientific Committee of the Sociedad Española de Nutrición Parenteral y Enteral (SENPE) and the Nutricia Advanced Medical Nutrition company began this Course some years ago, and now, it is a referent course in the multidisciplinary training of Clinical Nutrition. With this issue we review the advances in Clinical Nutrition in different situations and, this year, the topic is the malnutrition in chronic complex patients.

Career Opportunities in Texas: A Master Plan for Vocational and Technical Education (1989 Update).

ERIC Educational Resources Information Center

Texas State Board of Education, Austin.

In January 1987, a Master Plan for the delivery of vocational and technical education in Texas was adopted by the State Board of Education (SBOE). The master plan details goals and strategies to assist in the development of a skilled and educated work force in Texas as the state enters the 21st century. As part of their mandated annual review…

Seeking the Balance: Risks, Choices and Life Priorities in the Life-Patterns Project, 1998-1999. Working Paper 19.

ERIC Educational Resources Information Center

Dwyer, Peter; Harwood, Aramiha; Tyler, Debra

This paper provides an update on the 1998 findings from an Australian longitudinal study begun in 1991 and titled the Life-Patterns Project. Based on 1,430 returns of the questionnaire and interviews of a sub-sample of 100, it examines implications of patterns beginning to emerge as participants enter their mid-twenties and reassess their…

Simultaneous processing of photographic and accelerator array data from sled impact experiment

NASA Astrophysics Data System (ADS)

Ash, M. E.

1982-12-01

A Quaternion-Kalman filter model is derived to simultaneously analyze accelerometer array and photographic data from sled impact experiments. Formulas are given for the quaternion representation of rotations, the propagation of dynamical states and their partial derivatives, the observables and their partial derivatives, and the Kalman filter update of the state given the observables. The observables are accelerometer and tachometer velocity data of the sled relative to the track, linear accelerometer array and photographic data of the subject relative to the sled, and ideal angular accelerometer data. The quaternion constraints enter through perfect constraint observations and normalization after a state update. Lateral and fore-aft impact tests are analyzed with FORTRAN IV software written using the formulas of this report.

Building health information technology capacity: they may come but will they use it?

PubMed

Burke-Bebee, Suzie; Wilson, Marisa; Buckley, Kathleen M

2012-10-01

Medical errors remain a major safety problem more than a decade after the Institute of Medicine reported 98 000 related deaths occur yearly in US hospitals. Medication errors account for one-third of these errors. Although medication reconciliation is an accepted care standard for patient safety, little evidence is available to make practice recommendations for primary care. The purpose of this study was to evaluate the effectiveness of using secure e-mail alerts within the reconciliation process on patient medication safety in clinics where electronic and personal health records are used. A nonexperimental, descriptive design with a convenience sample of 62 patients from two Veterans Health Administration clinics was used. Patients received secure e-mail instructing them to review their online medication list, update it based on home medications, and bring it to the appointment for discussion with their provider. A retrospective chart review was conducted examining changes made to medication lists in the electronic record after reconciliation. Data revealed the organization's adoption of secure e-mail did not guarantee its meaningful use by providers and patients, a clear barrier to implementing technology as an adjunct to care in context of complex clinical processes such as medication reconciliation. Lessons learned from the project's implementation are discussed.

Nutritional support for critically ill children.

PubMed

Joffe, Ari; Anton, Natalie; Lequier, Laurance; Vandermeer, Ben; Tjosvold, Lisa; Larsen, Bodil; Hartling, Lisa

2016-05-27

Nutritional support in the critically ill child has not been well investigated and is a controversial topic within paediatric intensive care. There are no clear guidelines as to the best form or timing of nutrition in critically ill infants and children. This is an update of a review that was originally published in 2009. . The objective of this review was to assess the impact of enteral and parenteral nutrition given in the first week of illness on clinically important outcomes in critically ill children. There were two primary hypotheses:1. the mortality rate of critically ill children fed enterally or parenterally is different to that of children who are given no nutrition;2. the mortality rate of critically ill children fed enterally is different to that of children fed parenterally.We planned to conduct subgroup analyses, pending available data, to examine whether the treatment effect was altered by:a. age (infants less than one year versus children greater than or equal to one year old);b. type of patient (medical, where purpose of admission to intensive care unit (ICU) is for medical illness (without surgical intervention immediately prior to admission), versus surgical, where purpose of admission to ICU is for postoperative care or care after trauma).We also proposed the following secondary hypotheses (a priori), pending other clinical trials becoming available, to examine nutrition more distinctly:3. the mortality rate is different in children who are given enteral nutrition alone versus enteral and parenteral combined;4. the mortality rate is different in children who are given both enteral feeds and parenteral nutrition versus no nutrition. In this updated review we searched: the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 2); Ovid MEDLINE (1966 to February 2016); Ovid EMBASE (1988 to February 2016); OVID Evidence-Based Medicine Reviews; ISI Web of Science - Science Citation Index Expanded (1965 to February 2016); WebSPIRS Biological Abstracts (1969 to February 2016); and WebSPIRS CAB Abstracts (1972 to February 2016). We also searched trial registries, reviewed reference lists of all potentially relevant studies, handsearched relevant conference proceedings, and contacted experts in the area and manufacturers of enteral and parenteral nutrition products. We did not limit the search by language or publication status. We included studies if they were randomized controlled trials; involved paediatric patients, aged one day to 18 years of age, who were cared for in a paediatric intensive care unit setting (PICU) and had received nutrition within the first seven days of admission; and reported data for at least one of the pre-specified outcomes (30-day or PICU mortality; length of stay in PICU or hospital; number of ventilator days; and morbid complications, such as nosocomial infections). We excluded studies if they only reported nutritional outcomes, quality of life assessments, or economic implications. Furthermore, we did not address other areas of paediatric nutrition, such as immunonutrition and different routes of delivering enteral nutrition, in this review. Two authors independently screened the searches, applied the inclusion criteria, and performed 'Risk of bias' assessments. We resolved discrepancies through discussion and consensus. One author extracted data and a second checked data for accuracy and completeness. We graded the evidence based on the following domains: study limitations, consistency of effect, imprecision, indirectness, and publication bias. We identified only one trial as relevant. Seventy-seven children in intensive care with burns involving more than 25% of the total body surface area were randomized to either enteral nutrition within 24 hours or after at least 48 hours. No statistically significant differences were observed for mortality, sepsis, ventilator days, length of stay, unexpected adverse events, resting energy expenditure, nitrogen balance, or albumin levels. We assessed the trial as having unclear risk of bias. We consider the quality of the evidence to be very low due to there being only one small trial. In the most recent search update we identified a protocol for a relevant randomized controlled trial examining the impact of withholding early parenteral nutrition completing enteral nutrition in pediatric critically ill patients; no results have been published. There was only one randomized trial relevant to the review question. Research is urgently needed to identify best practices regarding the timing and forms of nutrition for critically ill infants and children.

Vaccination Against Tuberculosis With Whole-Cell Mycobacterial Vaccines.

PubMed

Scriba, Thomas J; Kaufmann, Stefan H E; Henri Lambert, Paul; Sanicas, Melvin; Martin, Carlos; Neyrolles, Olivier

2016-09-01

Live attenuated and killed whole-cell vaccines (WCVs) offer promising vaccination strategies against tuberculosis. A number of WCV candidates, based on recombinant bacillus Calmette-Guerin (BCG), attenuated Mycobacterium tuberculosis, or related mycobacterial species are in various stages of preclinical or clinical development. In this review, we discuss the vaccine candidates and key factors shaping the development pathway for live and killed WCVs and provide an update on progress. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Defense Health Care: More-Specific Guidance Needed for Assessing Nonenrolled TRICARE Beneficiaries’ Access to Care

DTIC Science & Technology

2014-04-01

doctor or nurse possible and 10 is the best personal doctor or nurse possible, what number would you use to rate your personal doctor or nurse ?” For...was it to get a personal doctor or nurse you are happy with?” For access to specialist doctor: “In the last 12 months, how much of a problem, if any...additional information. Connect with GAO on Facebook, Flickr, Twitter, and YouTube . Subscribe to our RSS Feeds or E-mail Updates. Listen to our Podcasts

The Strategic Lessons Unlearned from Vietnam, Iraq, and Afghanistan: Why the Afghan National Security Forces Will Not Hold, and the Implications for the U.S. Army in Afghanistan

DTIC Science & Technology

2015-06-01

information is estimated to average 1 hour per response, including the time for reviewing instructions , searching existing data sources, gathering and...provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid...publishes a monthly email newsletter to update the national security community on the research of our analysts, recent and forthcoming publications

Memory-updating abrogates extinction of learned immunosuppression.

PubMed

Hadamitzky, Martin; Bösche, Katharina; Wirth, Timo; Buck, Benjamin; Beetz, Oliver; Christians, Uwe; Schniedewind, Björn; Lückemann, Laura; Güntürkün, Onur; Engler, Harald; Schedlowski, Manfred

2016-02-01

When memories are recalled, they enter a transient labile phase in which they can be impaired or enhanced followed by a new stabilization process termed reconsolidation. It is unknown, however, whether reconsolidation is restricted to neurocognitive processes such as fear memories or can be extended to peripheral physiological functions as well. Here, we show in a paradigm of behaviorally conditioned taste aversion in rats memory-updating in learned immunosuppression. The administration of sub-therapeutic doses of the immunosuppressant cyclosporin A together with the conditioned stimulus (CS/saccharin) during retrieval blocked extinction of conditioned taste aversion and learned suppression of T cell cytokine (interleukin-2; interferon-γ) production. This conditioned immunosuppression is of clinical relevance since it significantly prolonged the survival time of heterotopically transplanted heart allografts in rats. Collectively, these findings demonstrate that memories can be updated on both neural and behavioral levels as well as on the level of peripheral physiological systems such as immune functioning. Copyright © 2015 Elsevier Inc. All rights reserved.

Computer literacy: Where are nurse educators on the continuum?

PubMed

Hanley, Elizabeth

2006-01-01

Computers are becoming ubiquitous in health and education, and it is expected that nurses from undergraduate nursing programmes are computer literate when they enter the workforce. Similarly nurse educators are expected to be computer literate to model the use of information technology in their workplace. They are expected to use email for communication and a range of computer applications for presentation of course materials and reports. Additionally, as more courses are delivered in flexible mode, educators require more comprehensive computing skills, including confidence and competence in a range of applications. A cohort of nurse educators from one tertiary institution was surveyed to assess their perceived computer literacy and how they attained this. A questionnaire that covered seven domains of computer literacy was used to assess this. The results were illuminating and identified specific training needs for this group. Their perceived lack of skill with Groupwise email and the student database program are of concern as these are essential tools for nurse educators at this polytechnic.

Systematic Review: A Reevaluation and Update of the Integrative (Trajectory) Model of Pediatric Medical Traumatic Stress.

PubMed

Price, Julia; Kassam-Adams, Nancy; Alderfer, Melissa A; Christofferson, Jennifer; Kazak, Anne E

2016-01-01

The objective of this systematic review is to reevaluate and update the Integrative Model of Pediatric Medical Traumatic Stress (PMTS; Kazak et al., 2006), which provides a conceptual framework for traumatic stress responses across pediatric illnesses and injuries. Using established systematic review guidelines, we searched PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and PubMed (producing 216 PMTS papers published since 2005), extracted findings for review, and organized and interpreted findings within the Integrative Model framework. Recent PMTS research has included additional pediatric populations, used advanced longitudinal modeling techniques, clarified relations between parent and child PMTS, and considered effects of PMTS on health outcomes. Results support and extend the model's five assumptions, and suggest a sixth assumption related to health outcomes and PMTS. Based on new evidence, the renamed Integrative Trajectory Model includes phases corresponding with medical events, adds family-centered trajectories, reaffirms a competency-based framework, and suggests updated assessment and intervention implications. © The Author 2015. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Out-of-School Time Programs for Older Youth. Research Update: Highlights from the Out-of-School Time Database. Number 7

ERIC Educational Resources Information Center

Harvard Family Research Project, 2011

2011-01-01

Out-of-school time (OST) programs focused on older youth--specifically, youth in middle and high school--can help participants successfully navigate their adolescence and learn new skills well into their teens. OST programs can also help prepare older youth for a variety of new roles that they will assume as they enter college and the workforce.…

Facilitating Successful Re-Entries in the United States: Training and Development for Women Returners

ERIC Educational Resources Information Center

Greer, Tomika W.

2013-01-01

Women returners are women who leave the paid workforce for a period of time following the birth of their child(ren) and subsequently seek to return to paid employment. As women returners attempt to re-enter the workforce, many of them are in need of updating their skills or re-training in a new set of skills. In this study, the training and…

A Cognitive Architecture for Human Performance Process Model Research

DTIC Science & Technology

1992-11-01

individually defined, updatable world representation which is a description of the world as the operator knows it. It contains rules for decisions, an...operate it), and rules of engagement (knowledge about the operator’s expected behavior). The HPP model works in the following way. Information enters...based models depict the problem-solving processes of experts. The experts’ knowledge is represented in symbol structures, along with rules for

The Community WRF-Hydro Modeling System Version 4 Updates: Merging Toward Capabilities of the National Water Model

NASA Astrophysics Data System (ADS)

McAllister, M.; Gochis, D.; Dugger, A. L.; Karsten, L. R.; McCreight, J. L.; Pan, L.; Rafieeinasab, A.; Read, L. K.; Sampson, K. M.; Yu, W.

2017-12-01

The community WRF-Hydro modeling system is publicly available and provides researchers and operational forecasters a flexible and extensible capability for performing multi-scale, multi-physics options for hydrologic modeling that can be run independent or fully-interactive with the WRF atmospheric model. The core WRF-Hydro physics model contains very high-resolution descriptions of terrestrial hydrologic process representations such as land-atmosphere exchanges of energy and moisture, snowpack evolution, infiltration, terrain routing, channel routing, basic reservoir representation and hydrologic data assimilation. Complementing the core physics components of WRF-Hydro are an ecosystem of pre- and post-processing tools that facilitate the preparation of terrain and meteorological input data, an open-source hydrologic model evaluation toolset (Rwrfhydro), hydrologic data assimilation capabilities with DART and advanced model visualization capabilities. The National Center for Atmospheric Research (NCAR), through collaborative support from the National Science Foundation and other funding partners, provides community support for the entire WRF-Hydro system through a variety of mechanisms. This presentation summarizes the enhanced user support capabilities that are being developed for the community WRF-Hydro modeling system. These products and services include a new website, open-source code repositories, documentation and user guides, test cases, online training materials, live, hands-on training sessions, an email list serve, and individual user support via email through a new help desk ticketing system. The WRF-Hydro modeling system and supporting tools which now include re-gridding scripts and model calibration have recently been updated to Version 4 and are merging toward capabilities of the National Water Model.

Survey Email Scheduling and Monitoring in eRCTs (SESAMe): A Digital Tool to Improve Data Collection in Randomized Controlled Clinical Trials.

PubMed

Skonnord, Trygve; Steen, Finn; Skjeie, Holgeir; Fetveit, Arne; Brekke, Mette; Klovning, Atle

2016-11-22

Electronic questionnaires can ease data collection in randomized controlled trials (RCTs) in clinical practice. We found no existing software that could automate the sending of emails to participants enrolled into an RCT at different study participant inclusion time points. Our aim was to develop suitable software to facilitate data collection in an ongoing multicenter RCT of low back pain (the Acuback study). For the Acuback study, we determined that we would need to send a total of 5130 emails to 270 patients recruited at different centers and at 19 different time points. The first version of the software was tested in a pilot study in November 2013 but was unable to deliver multiuser or Web-based access. We resolved these shortcomings in the next version, which we tested on the Web in February 2014. Our new version was able to schedule and send the required emails in the full-scale Acuback trial that started in March 2014. The system architecture evolved through an iterative, inductive process between the project study leader and the software programmer. The program was tested and updated when errors occurred. To evaluate the development of the software, we used a logbook, a research assistant dialogue, and Acuback trial participant queries. We have developed a Web-based app, Survey Email Scheduling and Monitoring in eRCTs (SESAMe), that monitors responses in electronic surveys and sends reminders by emails or text messages (short message service, SMS) to participants. The overall response rate for the 19 surveys in the Acuback study increased from 76.4% (655/857) before we introduced reminders to 93.11% (1149/1234) after the new function (P<.001). Further development will aim at securing encryption and data storage. The SESAMe software facilitates consecutive patient data collection in RCTs and can be used to increase response rates and quality of research, both in general practice and in other clinical trial settings. ©Trygve Skonnord, Finn Steen, Holgeir Skjeie, Arne Fetveit, Mette Brekke, Atle Klovning. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 22.11.2016.

ESPEN guidelines on definitions and terminology of clinical nutrition.

PubMed

Cederholm, T; Barazzoni, R; Austin, P; Ballmer, P; Biolo, G; Bischoff, S C; Compher, C; Correia, I; Higashiguchi, T; Holst, M; Jensen, G L; Malone, A; Muscaritoli, M; Nyulasi, I; Pirlich, M; Rothenberg, E; Schindler, K; Schneider, S M; de van der Schueren, M A E; Sieber, C; Valentini, L; Yu, J C; Van Gossum, A; Singer, P

2017-02-01

A lack of agreement on definitions and terminology used for nutrition-related concepts and procedures limits the development of clinical nutrition practice and research. This initiative aimed to reach a consensus for terminology for core nutritional concepts and procedures. The European Society of Clinical Nutrition and Metabolism (ESPEN) appointed a consensus group of clinical scientists to perform a modified Delphi process that encompassed e-mail communication, face-to-face meetings, in-group ballots and an electronic ESPEN membership Delphi round. Five key areas related to clinical nutrition were identified: concepts; procedures; organisation; delivery; and products. One core concept of clinical nutrition is malnutrition/undernutrition, which includes disease-related malnutrition (DRM) with (eq. cachexia) and without inflammation, and malnutrition/undernutrition without disease, e.g. hunger-related malnutrition. Over-nutrition (overweight and obesity) is another core concept. Sarcopenia and frailty were agreed to be separate conditions often associated with malnutrition. Examples of nutritional procedures identified include screening for subjects at nutritional risk followed by a complete nutritional assessment. Hospital and care facility catering are the basic organizational forms for providing nutrition. Oral nutritional supplementation is the preferred way of nutrition therapy but if inadequate then other forms of medical nutrition therapy, i.e. enteral tube feeding and parenteral (intravenous) nutrition, becomes the major way of nutrient delivery. An agreement of basic nutritional terminology to be used in clinical practice, research, and the ESPEN guideline developments has been established. This terminology consensus may help to support future global consensus efforts and updates of classification systems such as the International Classification of Disease (ICD). The continuous growth of knowledge in all areas addressed in this statement will provide the foundation for future revisions. Copyright © 2016 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd.. All rights reserved.

Revised methane emissions factors and spatially distributed annual carbon fluxes for global livestock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolf, Julie; Asrar, Ghassem R.; West, Tristram O.

Background: Livestock play an important role in carbon cycling through consumption of biomass and emissions of methane. Recent research suggests that existing bottom-up inventories of livestock methane emissions in the US, such as those made using 2006 IPCC Tier 1 livestock emissions factors, are too low. This may be due to outdated information used to develop these emissions factors. In this study, we update information for cattle and swine by region, based on reported recent changes in animal body mass, feed quality and quantity, milk productivity, and management of animals and manure. We then use this updated information to calculatemore » new livestock methane emissions factors for enteric fermentation in cattle, and for manure management in cattle and swine.« less

IRIS Toxicological Review of Benzo[a]pyrene (Interagency ...

EPA Pesticide Factsheets

In January 2017, EPA finalized the IRIS assessment of Benzo[a]pyrene. The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science discussion materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Benzo[a]pyrene are posted on this site. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for benzo[a]pyrene (BaP). The outcome of this project is an updated Toxicological Review and IRIS Summary for BaP that will be entered into the IRIS database.

Evolution of robot-assisted orthotopic ileal neobladder formation: a step-by-step update to the University of Southern California (USC) technique.

PubMed

Chopra, Sameer; de Castro Abreu, Andre Luis; Berger, Andre K; Sehgal, Shuchi; Gill, Inderbir; Aron, Monish; Desai, Mihir M

2017-01-01

To describe our, step-by-step, technique for robotic intracorporeal neobladder formation. The main surgical steps to forming the intracorporeal orthotopic ileal neobladder are: isolation of 65 cm of small bowel; small bowel anastomosis; bowel detubularisation; suture of the posterior wall of the neobladder; neobladder-urethral anastomosis and cross folding of the pouch; and uretero-enteral anastomosis. Improvements have been made to these steps to enhance time efficiency without compromising neobladder configuration. Our technical improvements have resulted in an improvement in operative time from 450 to 360 min. We describe an updated step-by-step technique of robot-assisted intracorporeal orthotopic ileal neobladder formation. © 2016 The Authors BJU International © 2016 BJU International Published by John Wiley & Sons Ltd.

Joint Operation Planning and Execution

DTIC Science & Technology

1992-03-01

Review Force Cargo Category Record ............. 261 Review Cargo Details ........................... 262 Tailor Force Record...shown. Tailor Force Cargo, Figure 7.11, is displayed. 261 <Xmit> to accept the update as shown. Tailor Force Cargo, Figure 7.11, is displayed. To review...8217 ZARZS TUNSA P 4S IAP DI’J ENTER FFPN,NPINPF!N,LP/,NPA3E ,. 2,ENr. Figure 12.8 GEOFILE Display After reviewing Figure 12.8, navigate back to the GEOFILE

Automation of Military Civil Engineering and Site Design Functions: Software Evaluation

DTIC Science & Technology

1989-09-01

promising advantage over manual methods, USACERL is to evaluate available software to determine which, if any, is best suited to the type of civil...moved. Therefore, original surface data were assembled by scaling the northing and easting distances of field elevations and entering them manually into...in the software or requesting an update or addition to the software or manuals . Responses to forms submitted during the test were received at

MODIS Cloud Microphysics Product (MOD_PR06OD) Data Collection 6 Updates

NASA Technical Reports Server (NTRS)

Wind, Gala; Platnick, Steven; King, Michael D.

2014-01-01

The MODIS Cloud Optical and Microphysical Product (MOD_PR060D) for Data Collection 6 has entered full scale production. Aqua reprocessing is almost completed and Terra reprocessing will begin shortly. Unlike previous collections, the CHIMAERA code base allows for simultaneous processing for multiple sensors and the operational CHIMAERA 6.0.76 stream is also available for VIIRS and SEVIRI sensors and for our E-MAS airborne platform.

Quantitative and volume, conductivity and scatter changes in leucocytes of patients with acute undifferentiated febrile illness: a pilot study.

PubMed

Kalra, Varun; Ahmad, Sohaib; Shrivastava, Vikas; Mittal, Garima

2016-05-01

A single diagnostic test for acute undifferentiated febrile illnesses (AUFI) is elusive. This pilot study was undertaken on the premise that leucocytes, being the main cells of defence, undergo quantitative, structural and functional changes in AUFI. We evaluated the potential of volume, conductivity and scatter (VCS) parameters of leucocytes, generated with the haemogram report by the Coulter auto-analyzer, in differentiating the common etiologies of AUFI. The haematological and VCS data obtained from 800 controls and 200 cases of AUFI (50 cases each of acute malaria, dengue, scrub typhus and enteric fever) were retrieved for analysis. The cases and controls differed significantly with respect to relative numbers and the VCS parameters of neutrophils, lymphocytes and monocytes (p<0.05). The neutrophil and lymphocyte were significantly voluminous in acute malaria and scrub typhus as compared to dengue and enteric fevers (p<0.05). Enteric fever significantly enhanced the conductivity of neutrophils as compared to other subgroups while lymphocyte conductivity significantly differed from dengue and scrub typhus. Lymphocyte and neutrophil scatter values in malaria and scrub typhus were comparable but differed significantly from that in enteric fever. Etiology-specific changes occur in leucocytes, both in numbers and their VCS properties which can be identified without additional cost. © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.

PubMed

Pappas, Peter G; Kauffman, Carol A; Andes, David R; Clancy, Cornelius J; Marr, Kieren A; Ostrosky-Zeichner, Luis; Reboli, Annette C; Schuster, Mindy G; Vazquez, Jose A; Walsh, Thomas J; Zaoutis, Theoklis E; Sobel, Jack D

2016-02-15

It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances. © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Content and Design Features of Academic Health Sciences Libraries' Home Pages.

PubMed

McConnaughy, Rozalynd P; Wilson, Steven P

2018-01-01

The goal of this content analysis was to identify commonly used content and design features of academic health sciences library home pages. After developing a checklist, data were collected from 135 academic health sciences library home pages. The core components of these library home pages included a contact phone number, a contact email address, an Ask-a-Librarian feature, the physical address listed, a feedback/suggestions link, subject guides, a discovery tool or database-specific search box, multimedia, social media, a site search option, a responsive web design, and a copyright year or update date.

Alternative medicine: an update on cupping therapy.

PubMed

Chen, B; Li, M-Y; Liu, P-D; Guo, Y; Chen, Z-L

2015-07-01

To know the research progress of cupping therapy all over the world, the authors analyze the research of cupping therapy in recent 5 years. It indicates that cupping therapy can be applied to extensive curable disease, but has poor clinical evidence. Some improvements in the mechanism research of cupping therapy have been made, but it needs further research. The adverse events of cupping therapy attract attention. The standardization of cupping therapy has emerged. © The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America.

PubMed

Stevens, Dennis L; Bisno, Alan L; Chambers, Henry F; Dellinger, E Patchen; Goldstein, Ellie J C; Gorbach, Sherwood L; Hirschmann, Jan V; Kaplan, Sheldon L; Montoya, Jose G; Wade, James C

2014-07-15

A panel of national experts was convened by the Infectious Diseases Society of America (IDSA) to update the 2005 guidelines for the treatment of skin and soft tissue infections (SSTIs). The panel's recommendations were developed to be concordant with the recently published IDSA guidelines for the treatment of methicillin-resistant Staphylococcus aureus infections. The focus of this guideline is the diagnosis and appropriate treatment of diverse SSTIs ranging from minor superficial infections to life-threatening infections such as necrotizing fasciitis. In addition, because of an increasing number of immunocompromised hosts worldwide, the guideline addresses the wide array of SSTIs that occur in this population. These guidelines emphasize the importance of clinical skills in promptly diagnosing SSTIs, identifying the pathogen, and administering effective treatments in a timely fashion. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America.

PubMed

Stevens, Dennis L; Bisno, Alan L; Chambers, Henry F; Dellinger, E Patchen; Goldstein, Ellie J C; Gorbach, Sherwood L; Hirschmann, Jan V; Kaplan, Sheldon L; Montoya, Jose G; Wade, James C

2014-07-15

A panel of national experts was convened by the Infectious Diseases Society of America (IDSA) to update the 2005 guidelines for the treatment of skin and soft tissue infections (SSTIs). The panel's recommendations were developed to be concordant with the recently published IDSA guidelines for the treatment of methicillin-resistant Staphylococcus aureus infections. The focus of this guideline is the diagnosis and appropriate treatment of diverse SSTIs ranging from minor superficial infections to life-threatening infections such as necrotizing fasciitis. In addition, because of an increasing number of immunocompromised hosts worldwide, the guideline addresses the wide array of SSTIs that occur in this population. These guidelines emphasize the importance of clinical skills in promptly diagnosing SSTIs, identifying the pathogen, and administering effective treatments in a timely fashion. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Real-Time Multimission Event Notification System for Mars Relay

NASA Technical Reports Server (NTRS)

Wallick, Michael N.; Allard, Daniel A.; Gladden, Roy E.; Wang, Paul; Hy, Franklin H.

2013-01-01

As the Mars Relay Network is in constant flux (missions and teams going through their daily workflow), it is imperative that users are aware of such state changes. For example, a change by an orbiter team can affect operations on a lander team. This software provides an ambient view of the real-time status of the Mars network. The Mars Relay Operations Service (MaROS) comprises a number of tools to coordinate, plan, and visualize various aspects of the Mars Relay Network. As part of MaROS, a feature set was developed that operates on several levels of the software architecture. These levels include a Web-based user interface, a back-end "ReSTlet" built in Java, and databases that store the data as it is received from the network. The result is a real-time event notification and management system, so mission teams can track and act upon events on a moment-by-moment basis. This software retrieves events from MaROS and displays them to the end user. Updates happen in real time, i.e., messages are pushed to the user while logged into the system, and queued when the user is not online for later viewing. The software does not do away with the email notifications, but augments them with in-line notifications. Further, this software expands the events that can generate a notification, and allows user-generated notifications. Existing software sends a smaller subset of mission-generated notifications via email. A common complaint of users was that the system-generated e-mails often "get lost" with other e-mail that comes in. This software allows for an expanded set (including user-generated) of notifications displayed in-line of the program. By separating notifications, this can improve a user's workflow.

The Role of Task Understanding on Younger and Older Adults' Performance.

PubMed

Frank, David J; Touron, Dayna R

2016-12-16

Age-related performance decrements have been linked to inferior strategic choices. Strategy selection models argue that accurate task representations are necessary for choosing appropriate strategies. But no studies to date have compared task representations in younger and older adults. Metacognition research suggests age-related deficits in updating and utilizing strategy knowledge, but other research suggests age-related sparing when information can be consolidated into a coherent mental model. Study 1 validated the use of concept mapping as a tool for measuring task representation accuracy. Study 2 measured task representations before and after a complex strategic task to test for age-related decrements in task representation formation and updating. Task representation accuracy and task performance were equivalent across age groups. Better task representations were related to better performance. However, task representation scores remained fairly stable over the task with minimal evidence of updating. Our findings mirror those in the mental model literature suggesting age-related sparing of strategy use when information can be integrated into a coherent mental model. Future research should manipulate the presence of a unifying context to better evaluate this hypothesis. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A Clinical Update and Global Economic Burden of Rheumatoid Arthritis.

PubMed

Fazal, Syed Ali; Khan, Mohammad; Nishi, Shamima E; Alam, Fahmida; Zarin, Nowshin; Bari, Mohammad T; Ashraf, Ghulam Md

2018-02-13

Rheumatoid arthritis (RA) is a predominant inflammatory autoimmune disorder. The incidence and prevalence of RA is increasing with considerable morbidity and mortality worldwide. The pathophysiology of RA has become clearer due to many significant research outputs during the last two decades. Many inflammatory cytokines involved in RA pathophysiology and the presence of autoantibodies are being used as potential biomarkers via the use of effective diagnostic techniques for the early diagnosis of RA. Currently, several disease-modifying anti-rheumatic drugs are being prescribed targeting RA pathophysiology, which have shown significant contributions in improving the disease outcomes. Even though innovations in treatment strategies and monitoring are helping the patients to achieve early and sustained clinical and radiographic remission, the high cost of drugs and limited health care budgets are restricting the easy access of RA treatment. Both direct and indirect high cost of treatment are creating economic burden for the patients and affecting their quality of life. The aim of this review is to describe the updated concept of RA pathophysiology and highlight current diagnostic tools used for the early detection as well as prognosis - targeting several biomarkers of RA. Additionally, we explored the updated treatment options with side effects besides discussing the global economic burden. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Toward a descriptive model of galactic cosmic rays in the heliosphere

NASA Technical Reports Server (NTRS)

Mewaldt, R. A.; Cummings, A. C.; Adams, James H., Jr.; Evenson, Paul; Fillius, W.; Jokipii, J. R.; Mckibben, R. B.; Robinson, Paul A., Jr.

1988-01-01

Researchers review the elements that enter into phenomenological models of the composition, energy spectra, and the spatial and temporal variations of galactic cosmic rays, including the so-called anomalous cosmic ray component. Starting from an existing model, designed to describe the behavior of cosmic rays in the near-Earth environment, researchers suggest possible updates and improvements to this model, and then propose a quantitative approach for extending such a model into other regions of the heliosphere.

Real-time, interactive, visually updated simulator system for telepresence

NASA Technical Reports Server (NTRS)

Schebor, Frederick S.; Turney, Jerry L.; Marzwell, Neville I.

1991-01-01

Time delays and limited sensory feedback of remote telerobotic systems tend to disorient teleoperators and dramatically decrease the operator's performance. To remove the effects of time delays, key components were designed and developed of a prototype forward simulation subsystem, the Global-Local Environment Telerobotic Simulator (GLETS) that buffers the operator from the remote task. GLETS totally immerses an operator in a real-time, interactive, simulated, visually updated artificial environment of the remote telerobotic site. Using GLETS, the operator will, in effect, enter into a telerobotic virtual reality and can easily form a gestalt of the virtual 'local site' that matches the operator's normal interactions with the remote site. In addition to use in space based telerobotics, GLETS, due to its extendable architecture, can also be used in other teleoperational environments such as toxic material handling, construction, and undersea exploration.

Multiple-Feature Extracting Modules Based Leak Mining System Design

PubMed Central

Cho, Ying-Chiang; Pan, Jen-Yi

2013-01-01

Over the years, human dependence on the Internet has increased dramatically. A large amount of information is placed on the Internet and retrieved from it daily, which makes web security in terms of online information a major concern. In recent years, the most problematic issues in web security have been e-mail address leakage and SQL injection attacks. There are many possible causes of information leakage, such as inadequate precautions during the programming process, which lead to the leakage of e-mail addresses entered online or insufficient protection of database information, a loophole that enables malicious users to steal online content. In this paper, we implement a crawler mining system that is equipped with SQL injection vulnerability detection, by means of an algorithm developed for the web crawler. In addition, we analyze portal sites of the governments of various countries or regions in order to investigate the information leaking status of each site. Subsequently, we analyze the database structure and content of each site, using the data collected. Thus, we make use of practical verification in order to focus on information security and privacy through black-box testing. PMID:24453892

Multiple-feature extracting modules based leak mining system design.

PubMed

Cho, Ying-Chiang; Pan, Jen-Yi

2013-01-01

Over the years, human dependence on the Internet has increased dramatically. A large amount of information is placed on the Internet and retrieved from it daily, which makes web security in terms of online information a major concern. In recent years, the most problematic issues in web security have been e-mail address leakage and SQL injection attacks. There are many possible causes of information leakage, such as inadequate precautions during the programming process, which lead to the leakage of e-mail addresses entered online or insufficient protection of database information, a loophole that enables malicious users to steal online content. In this paper, we implement a crawler mining system that is equipped with SQL injection vulnerability detection, by means of an algorithm developed for the web crawler. In addition, we analyze portal sites of the governments of various countries or regions in order to investigate the information leaking status of each site. Subsequently, we analyze the database structure and content of each site, using the data collected. Thus, we make use of practical verification in order to focus on information security and privacy through black-box testing.

Enteral tube feeding for cystic fibrosis.

PubMed

Conway, S P; Morton, A; Wolfe, S

2008-04-16

Enteral tube feeding is routinely used in many cystic fibrosis centres when weight for height percentage is less than 85%, when there has been weight loss for longer than a two-month period or when there has been no weight gain for two to three months (under five years old) or for six months (over five years old). To examine the evidence that in people with cystic fibrosis supplemental enteral tube feeding improves nutritional status, respiratory function, and quality of life without significant adverse effects. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We also contacted the companies that market enteral feeds and reviewed their databases. Date of the most recent search of the Group's Cystic Fibrosis Trials Register: November 2007. All randomised controlled trials comparing supplemental enteral tube feeding for one month or longer with no specific intervention in people with cystic fibrosis. Thirteen trials were identified by the search; however, none were eligible for inclusion in this review. There are no trials included in this review. Supplemental enteral tube feeding is widely used throughout the world to improve nutritional status in people with cystic fibrosis. The methods mostly used, nasogastric or gastrostomy feeding, are invasive, expensive, and may have a negative effect on self-esteem and body image. Reported use of enteral tube feeding suggests that it results in nutritional and respiratory improvement and it is disappointing that their efficacy has not been fully assessed by randomised controlled trials. With the more frequent recommendations to use enteral tube feeding as an early rather than a late intervention, this systematic review identifies the need for a multicentre, randomised controlled trial assessing both efficacy and possible adverse effects of enteral tube feeding in cystic fibrosis. There are no trials included in the review and we have not identified any relevant trials up to November 2007. We therefore do not plan to update this review until new trials are published.

76 FR 9231 - New Customs Declarations Label Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

...The Postal Service is revising the Mailing Standards of the United States Postal Service, Domestic Mail Manual (DMM[supreg]) 608.2.4 to require all mailpieces containing goods that enter the Customs Territory of the United States (CTUS), from outside the CTUS, to bear a customs declaration label. Additionally, the Postal Service updates the standards for items weighing 16 ounces or more when sent to, from, or between, and in some circumstances, within certain U.S. territories, possessions, and Freely Associated States.

Connectionist Models: Proceedings of the Summer School Held in San Diego, California on 1990

DTIC Science & Technology

1990-01-01

modes: control network continues activation spreading based There is the sequential version and the parallel version on the actual inputs instead of...ent). 2. Execute all motoric actions based on activations of r a ent.The parallel version of the algorithm is local in time, units in A. Update the...a- movements that help o recognize an entering person.) tions like ’move focus left’, ’rotate focus’ are based on the activations of the C’s output

PFGE, Lior Serotype, and Antimicrobial Resistance Patterns Among Campylobacter jejuni Isolated from Travelers and US Military Personnel with Acute Diarrhea in Thailand, 1998-2003

DTIC Science & Technology

2010-01-01

subtyping Salmonella spp., Shigella spp., and Vibrio spp., in addition to C. jejttni 112,13]. Unlike other enteric bacteria, Campylobacter is a...Campylobacter jejuni and Campylobacter col/Isolated from raw chicken meat and human stools in Korea. J Food Prot 2006, 69:2915-2923. 7. Harvey SM...coli 01 57:H7, non-typhoidal Salmonella serotypes, and Shigella sonnei by pulsed-field gel electrophoresis (PFGE). PulseNet 8th Annual Update

MITOPRED: a web server for the prediction of mitochondrial proteins

PubMed Central

Guda, Chittibabu; Guda, Purnima; Fahy, Eoin; Subramaniam, Shankar

2004-01-01

MITOPRED web server enables prediction of nucleus-encoded mitochondrial proteins in all eukaryotic species. Predictions are made using a new algorithm based primarily on Pfam domain occurrence patterns in mitochondrial and non-mitochondrial locations. Pre-calculated predictions are instantly accessible for proteomes of Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila, Homo sapiens, Mus musculus and Arabidopsis species as well as all the eukaryotic sequences in the Swiss-Prot and TrEMBL databases. Queries, at different confidence levels, can be made through four distinct options: (i) entering Swiss-Prot/TrEMBL accession numbers; (ii) uploading a local file with such accession numbers; (iii) entering protein sequences; (iv) uploading a local file containing protein sequences in FASTA format. Automated updates are scheduled for the pre-calculated prediction database so as to provide access to the most current data. The server, its documentation and the data are available from http://mitopred.sdsc.edu. PMID:15215413

IRIS Toxicological Review and Summary Documents for N ...

EPA Pesticide Factsheets

EPA's assessment of the noncancer health effects and carcinogenic potential of n-hexane was last prepared and added to the IRIS data base in 1990. The IRIS program is updating the IRIS assessment for n-hexane; this update will incorporate health effects information published since the last assessment was prepared as well as new risk assessment methods. The IRIS assessment for n-hexane will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physicochemical and toxicokinetic properties of the chemical and its toxicity in humans and experimental systems. The assessment will present reference values for noncancer effects of n-hexane (RfD and RfC) and a cancer assessment, where supported by available data. The Toxicological Review and IRIS Summary will be subject to internal peer consultation, Agency review, and external scientific peer review. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for n-hexane. The outcome of this project is an updated Toxicological Review and IRIS Summary for n-Hexane that will be entered into the IRIS database. IRIS is an EPA data base containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment

Update on metabolism and nutrition therapy in critically ill burn patients.

PubMed

Moreira, E; Burghi, G; Manzanares, W

Major burn injury triggers severe oxidative stress, a systemic inflammatory response, and a persistent hypermetabolic and hypercatabolic state with secondary sarcopenia, multiorgan dysfunction, sepsis and an increased mortality risk. Calorie deficit, negative protein balance and antioxidant micronutrient deficiency after thermal injury have been associated to poor clinical outcomes. In this context, personalized nutrition therapy with early enteral feeding from the start of resuscitation are indicated. Over the last four decades, different nutritional and pharmacological interventions aimed at modulating the immune and metabolic responses have been evaluated. These strategies have been shown to be able to minimize acute malnutrition, as well as modulate the immunoinflammatory response, and improve relevant clinical outcomes in this patient population. The purpose of this updating review is to summarize the most current evidence on metabolic response and nutrition therapy in critically ill burn patients. Copyright © 2017 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

Updated Starshade Technology Gap List

NASA Astrophysics Data System (ADS)

Crill, Brendan P.; Siegler, Nicholas

2017-01-01

NASA's Exoplanet Exploration Program (ExEP) guides the development of technology that enables the direct imaging and characterization of exo-Earths in the habitable zone of their stars, for future space observatories. Here we present the Starshade portion of the 2017 ExEP Enabling Technology Gap List, an annual update to ExEP's list of of technology to be advanced in the next 1-5 years. A Starshade is an external occulter on an independent spacecraft, allowing a space telescope to achieve exo-Earth imaging contrast requirements by blocking starlight before it enters the telescope. Building and operating a Starshade requires new technology: the occulter is a structure tens of meters in diameter that must be positioned precisely at a distance of tens of thousands of kilometers from the telescope. We review the current state-of-the-art performance and the performance level that must be achieved for a Starshade.

IRIS Toxicological Review of Benzo[a]pyrene (Interagency ...

EPA Pesticide Factsheets

On August 21, 2013, the draft Toxicological Review of Benzo[a]pyrene and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Benzo[a]pyrene and the charge to external peer reviewers, are posted on this site. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for benzo[a]pyrene (BaP). The outcome of this project is an updated Toxicological Review and IRIS Summary for BaP that will be entered into the IRIS database.

Enteroaggregative Escherichia coli: An Emerging Enteric Food Borne Pathogen.

PubMed

Kaur, P; Chakraborti, A; Asea, A

2010-01-01

Enteroaggregative Escherichia coli (EAEC) are quite heterogeneous category of an emerging enteric pathogen associated with cases of acute or persistent diarrhea worldwide in children and adults, and over the past decade has received increasing attention as a cause of watery diarrhea, which is often persistent. EAEC infection is an important cause of diarrhea in outbreak and non-outbreak settings in developing and developed countries. Recently, EAEC has been implicated in the development of irritable bowel syndrome, but this remains to be confirmed. EAEC is defined as a diarrheal pathogen based on its characteristic aggregative adherence (AA) to HEp-2 cells in culture and its biofilm formation on the intestinal mucosa with a "stacked-brick" adherence phenotype, which is related to the presence of a 60 MDa plasmid (pAA). At the molecular level, strains demonstrating the aggregative phenotype are quite heterogeneous; several virulence factors are detected by polymerase chain reaction; however, none exhibited 100% specificity. Although several studies have identified specific virulence factor(s) unique to EAEC, the mechanism by which EAEC exerts its pathogenesis is, thus, far unknown. The present review updates the current knowledge on the epidemiology, chronic complications, detection, virulence factors, and treatment of EAEC, an emerging enteric food borne pathogen.

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update.

PubMed

Chaves, Sílvia; Piemontese, Luca; Hiremathad, Asha; Santos, Maria A

2018-01-01

Hydroxypyridinones (HPs) are a family of N-heterocyclic metal chelators, which have been an attractive target in the development of a variety of new pharmaceutical drugs, due to their high metal chelating efficacy/specificity and easy derivatization to tune the desired biological properties. In fact, along the last decades, hydroxypyridinone derivatives, but mostly 3-hydroxy-4-pyridinone (3,4-HP), have been intensively used in drug design, following either a multitarget approach, in which one chelating unity is extrafunctionalized (hybridized) to enable the interaction with other important specific biological sites, or a polydenticity approach, in which more than one chelating moiety is conveniently attached to one scaffold, to increase the metal chelating efficacy. This review represents an update of the most recent publications (2014-2016) in mono-HP hybrids, namely as potential anti-Alzheimer's drugs, inhibitors of metalloenzymes and anti-microbials, and also polychelating compounds (poly- HP), in view of potential application, such as anti-microbial/biostatic agents, luminescent biosensors or diagnostic agents. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Writing Electron Dot Structures: Abstract of Issue 9905M

NASA Astrophysics Data System (ADS)

Magnell, Kenneth R.

1999-10-01

Writing Electron Dot Structures is a computer program for Mac OS that provides drill with feedback for students learning to write electron dot structures. While designed for students in the first year of college general chemistry it may also be used by high school chemistry students. A systematic method similar to that found in many general chemistry texts is employed:

1. determine the number of valence shell electrons,
2. select the central atom,
3. construct a skeleton,
4. add electrons to complete octets,
5. examine the structure for resonance forms.

To Create a Consensus on Malnutrition Diagnostic Criteria.

PubMed

Cederholm, Tommy; Jensen, Gordon L

2017-03-01

During the European Society for Clinical Nutrition and Metabolism (ESPEN) Congress in Copenhagen, Denmark (September 2016), representatives of the 4 largest global parenteral and enteral nutrition (PEN) societies from Europe (ESPEN), the United States (American Society for Parenteral and Enteral Nutrition [ASPEN]), Asia (Parenteral and Enteral Nutrition Society of Asia [PENSA]), and Latin America (Latin American Federation of Parenteral and Enteral Nutrition [FELANPE]) and from national PEN societies around the world met to continue the conversation on how to diagnose malnutrition that started during the Clinical Nutrition Week, Austin, Texas (February 2016). Current thinking on diagnostic approaches was shared; ESPEN suggested a grading approach that could encompass various types of signs, symptoms, and etiologies to support diagnosis. ASPEN emphasized where the parties agree; that is, that the 3 major published approaches (ESPEN, ASPEN-Academy of Nutrition and Dietetics, and Subjective Global Assessment [SGA]) all propose weight loss as a key indicator for malnutrition. FELANPE suggested that the anticipated consensus approach needs to prioritize a diagnostic method that is available for everybody since resources differ globally. PENSA highlighted that body mass index varies by ethnicity/race and that sarcopenia/muscle mass evaluation is important for the diagnosis of malnutrition. A Core Working Committee of the Global Leadership Initiative on Malnutrition has been established (comprising 2 representatives each from the 4 largest PEN societies) that will lead consensus development in collaboration with a larger working group with broad global representation, using e-mail, telephone conferences, and face-to-face meetings during the upcoming ASPEN and ESPEN congresses. Transparency and external input will be sought. Objectives include (1) consensus development around evidence-based criteria for broad application, (2) promotion of global dissemination of the consensus criteria, and (3) seeking adoption by the World Health Organization and the International Classification of Diseases.

Tracking Student Progress Through an On-Line Astro101 Module

NASA Astrophysics Data System (ADS)

Howard, W. H., II; Hufnagel, B.

2004-05-01

We present an on-line module that helps introductory-level, non-science undergraduates extract information about neutron star binary star systems from X-ray light curves. The students interface directly with the High Energy Astrophysics Science Archive Research Center (HEASARC) data through CollegeHera. Hera is a new service offered by HEASARC that enables complete interactive analysis of archived data products (see the separate Lochner & Pence paper this meeting). One of the innovative features of this module is that it records detailed student progress and automatically reports this to the professor. As the student moves through the module, student answers to multiple choice and free response questions are recorded in a personal file on the server. This is an authenticated process. The student must fill out a registration form that includes their name, course, email, professor, and professor's email. This creates a session cookie for the student that stores the unique ID given to the user by the server. In turn, the unique ID is linked to the one file that records the student's responses. When the module is completed, a brief confirmation email is sent to the student, excluding the student's unique answers to discourage sharing with other students. Simultaneously, the professor entered during the registration receives an email with the student responses and their time of entry. PERL is used for all server-side programming, and form validation functions were written in JavaScript. A laptop with internet access will be available at the poster for participants to explore the module. Learning goals and other education information for the module are at a related paper in this meeting, Hufnagel, Lochner & Howard. This module required extensive cooperation with the Hera team, and was based on a module developed by James Lochner. Irina Nelson, formerly of the Office of University Programs at GSFC, conceived the overall project. Support for this work was provided by the Southeast Regional Clearinghouse (SERCH) and the Maryland Space Grant Consortium.

Electricity unplugged

NASA Astrophysics Data System (ADS)

Karalis, Aristeidis

2009-02-01

The judge was driving back late one cold winter night. Entering the garage, the battery-charging indicator in his wirelessly powered electric car came on. "Home at last," crossed his mind. He swiped his personal smartcard on the front-door detector to be let in. He heard a "charging" beep from his mobile phone. The blinking cursor on the half-finished e-mail on the laptop had been waiting all day on the side table. He picked the computer up and walked towards his desk. "Good evening, your honour. Your wirelessly heated robe," said the butler-robot as it approached from the kitchen. Putting on the electric garment, he sat on the medical desk chair. His artificial heart was now beating faster.

Public health communication with frontline clinicians during the first wave of the 2009 influenza pandemic

PubMed Central

Staes, Catherine J.; Wuthrich, Amyanne; Gesteland, Per; Allison, Mandy A.; Leecaster, Molly; Shakib, Julie H.; Carter, Marjorie E.; Mallin, Brittany M.; Mottice, Susan; Rolfs, Robert; Pavia, Andrew T.; Wallace, Brent; Gundlapalli, Adi V.; Samore, Matthew; Byington, Carrie L.

2011-01-01

Context During public health emergencies, office-based frontline clinicians are critical partners in the detection, treatment, and control of disease. Communication between public health authorities and frontline clinicians is critical, yet public health agencies, medical societies, and healthcare delivery organizations have all called for improvements. Objectives Describe communication processes between public health and frontline clinicians during the first wave of the 2009 novel influenza A (H1N1) pandemic; assess clinicians’ use of and knowledge about public health guidance; and assess clinicians’ perceptions and preferences about communication during a public health emergency. Design and Methods During the first wave of the pandemic, we performed a process analysis and surveyed 509 office-based primary care providers in Utah. Setting and Participants Public health and healthcare leaders from major agencies involved in emergency response in Utah and office-based primary care providers located throughout Utah. Main Outcome Measure(s) Communication process and information flow, distribution of emails, proportion of clinicians that accessed key websites at least weekly, clinicians’ knowledge about recent guidance and perception about email load, primary information sources, and qualitative findings from clinician feedback. Results The process analysis revealed redundant activities and messaging. The 141 survey respondents (28%) received information from a variety of sources: 68% received information from state public health; almost 100% received information from healthcare organizations. Only 1/3 visited a state public health or institutional website frequently enough (at least weekly) to obtain updated guidance. Clinicians were knowledgeable about guidance that did not change during the first wave; however, correct knowledge was lower after guidance changed. Clinicians felt overwhelmed by email volume, preferred a single institutional email for clinical guidance, and suggested new information be concise and clearly identified. Conclusion Communication between public health, healthcare organizations, and clinicians was redundant, overwhelming, and can be enhanced considering clinician preferences and institutional communication channels. PMID:21135659

Public health communication with frontline clinicians during the first wave of the 2009 influenza pandemic.

PubMed

Staes, Catherine J; Wuthrich, Amyanne; Gesteland, Per; Allison, Mandy A; Leecaster, Molly; Shakib, Julie H; Carter, Marjorie E; Mallin, Brittany M; Mottice, Susan; Rolfs, Robert; Pavia, Andrew T; Wallace, Brent; Gundlapalli, Adi V; Samore, Matthew; Byington, Carrie L

2011-01-01

During public health emergencies, office-based frontline clinicians are critical partners in the detection, treatment, and control of disease. Communication between public health authorities and frontline clinicians is critical, yet public health agencies, medical societies, and healthcare delivery organizations have all called for improvements. Describe communication processes between public health and frontline clinicians during the first wave of the 2009 novel influenza A(H1N1) pandemic; assess clinicians' use of and knowledge about public health guidance; and assess clinicians' perceptions and preferences about communication during a public health emergency. During the first wave of the pandemic, we performed a process analysis and surveyed 509 office-based primary care providers in Utah. Public health and healthcare leaders from major agencies involved in emergency response in Utah and office-based primary care providers located throughout Utah. Communication process and information flow, distribution of e-mails, proportion of clinicians who accessed key Web sites at least weekly, clinicians' knowledge about recent guidance and perception about e-mail load, primary information sources, and qualitative findings from clinician feedback. The process analysis revealed redundant activities and messaging. The 141 survey respondents (28%) received information from a variety of sources: 68% received information from state public health; almost 100% received information from health care organizations. Only one-third visited a state public health or institutional Web site frequently enough (at least weekly) to obtain updated guidance. Clinicians were knowledgeable about guidance that did not change during the first wave; however, correct knowledge was lower after guidance changed. Clinicians felt overwhelmed by e-mail volume, preferred a single institutional e-mail for clinical guidance, and suggested that new information be concise and clearly identified. : Communication between public health, health care organizations and clinicians was redundant and overwhelming and can be enhanced considering clinician preferences and institutional communication channels.

[Update of PDE5 inhibitors as treatment of ED].

PubMed

Lu, Yong-ning; Chen, Bin

2005-07-01

Erectile dysfunction is a common ailment in middle-aged and old men. The management of ED has entered a new stage since sildenafil was used to treat ED in 1998. Sildenafil became the first-line treatment for its efficacy and safety. In recent years, new PDE5 inhibitors--vardenafil and tadalafil came into market in succession, providing more options available for oral therapy. This review is about the development of preclinical and clinical medicine research on the three PDE5 inhibitors, and provide information for clinical choices.

User's Guide for the Updated EST/BEST Software System

NASA Technical Reports Server (NTRS)

Shah, Ashwin

2003-01-01

This User's Guide describes the structure of the IPACS input file that reflects the modularity of each module. The structured format helps the user locate specific input data and manually enter or edit it. The IPACS input file can have any user-specified filename, but must have a DAT extension. The input file may consist of up to six input data blocks; the data blocks must be separated by delimiters beginning with the $ character. If multiple sections are desired, they must be arranged in the order listed.

Medicinal and other products and human and animal transmissible spongiform encephalopathies: memorandum from a WHO meeting.

PubMed Central

1997-01-01

The report in March 1996 of 10 human cases of a novel from of Creutzfeldt-Jakob disease in the United Kingdom, and its possible link to the agent that causes bovine spongiform encephalopathy (BSE), raises many questions about the safety of animal-derived products and by-products entering the food chain or being used in medicine. This Memorandum updates the preventive measures put forward in 1991 to minimize the risks associated with the use of bovine-derived materials in medicinal products and medical devices. PMID:9509622

Neurostimulation in clinical and sub-clinical eating disorders: a systematic update of the literature.

PubMed

Dalton, Bethan; Bartholdy, Savani; Campbell, Iain C; Schmidt, Ulrike

2018-01-07

Whilst psychological therapies are the main approach to treatment of eating disorders (EDs), advances in aetiological research suggest the need for the development of more targeted, brain-focused treatments. A range of neurostimulation approaches, most prominently repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS), are rapidly emerging as potential novel interventions. We have previously reviewed these techniques as potential treatments of EDs. To provide an update of the literature examining the effects of DBS, rTMS and tDCS on eating behaviours, body weight and associated symptoms in people with EDs and relevant analogue populations. Using PRISMA guidelines, we reviewed articles in PubMed, Web of Science, and PsycINFO from 1st January 2013 until 14th August 2017, to update our earlier search. Studies assessing the effects of neurostimulation techniques on eating and weight-related outcomes in people with EDs and relevant analogue populations were included. Data from both searches were combined. We included a total of 32 studies (526 participants); of these, 18 were newly identified by our update search. Whilst findings are somewhat mixed for bulimia nervosa, neurostimulation techniques have shown potential in the treatment of other EDs, in terms of reduction of ED and associated symptoms. Studies exploring cognitive, neural, and hormonal correlates of these techniques are also beginning to appear. Neurostimulation approaches show promise as treatments for EDs. As yet, large well-conducted randomised controlled trials are lacking. More information is needed about treatment targets, stimulation parameters and mechanisms of action. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Improving prediction of fall risk among nursing home residents using electronic medical records.

PubMed

Marier, Allison; Olsho, Lauren E W; Rhodes, William; Spector, William D

2016-03-01

Falls are physically and financially costly, but may be preventable with targeted intervention. The Minimum Data Set (MDS) is one potential source of information on fall risk factors among nursing home residents, but its limited breadth and relatively infrequent updates may limit its practical utility. Richer, more frequently updated data from electronic medical records (EMRs) may improve ability to identify individuals at highest risk for falls. The authors applied a repeated events survival model to analyze MDS 3.0 and EMR data for 5129 residents in 13 nursing homes within a single large California chain that uses a centralized EMR system from a leading vendor. Estimated regression parameters were used to project resident fall probability. The authors examined the proportion of observed falls within each projected fall risk decile to assess improvements in predictive power from including EMR data. In a model incorporating fall risk factors from the MDS only, 28.6% of observed falls occurred among residents in the highest projected risk decile. In an alternative specification incorporating more frequently updated measures for the same risk factors from the EMR data, 32.3% of observed falls occurred among residents in the highest projected risk decile, a 13% increase over the base MDS-only specification. Incorporating EMR data improves ability to identify those at highest risk for falls relative to prediction using MDS data alone. These improvements stem chiefly from the greater frequency with which EMR data are updated, with minimal additional gains from availability of additional risk factor variables. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America.

PubMed

Lucas, Gregory M; Ross, Michael J; Stock, Peter G; Shlipak, Michael G; Wyatt, Christina M; Gupta, Samir K; Atta, Mohamed G; Wools-Kaloustian, Kara K; Pham, Paul A; Bruggeman, Leslie A; Lennox, Jeffrey L; Ray, Patricio E; Kalayjian, Robert C

2014-11-01

It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.

PubMed

Ochoa-Cortes, Fernando; Turco, Fabio; Linan-Rico, Andromeda; Soghomonyan, Suren; Whitaker, Emmett; Wehner, Sven; Cuomo, Rosario; Christofi, Fievos L

2016-02-01

The word "glia" is derived from the Greek word "γλoια," glue of the enteric nervous system, and for many years, enteric glial cells (EGCs) were believed to provide mainly structural support. However, EGCs as astrocytes in the central nervous system may serve a much more vital and active role in the enteric nervous system, and in homeostatic regulation of gastrointestinal functions. The emphasis of this review will be on emerging concepts supported by basic, translational, and/or clinical studies, implicating EGCs in neuron-to-glial (neuroglial) communication, motility, interactions with other cells in the gut microenvironment, infection, and inflammatory bowel diseases. The concept of the "reactive glial phenotype" is explored as it relates to inflammatory bowel diseases, bacterial and viral infections, postoperative ileus, functional gastrointestinal disorders, and motility disorders. The main theme of this review is that EGCs are emerging as a new frontier in neurogastroenterology and a potential therapeutic target. New technological innovations in neuroimaging techniques are facilitating progress in the field, and an update is provided on exciting new translational studies. Gaps in our knowledge are discussed for further research. Restoring normal EGC function may prove to be an efficient strategy to dampen inflammation. Probiotics, palmitoylethanolamide (peroxisome proliferator-activated receptor-α), interleukin-1 antagonists (anakinra), and interventions acting on nitric oxide, receptor for advanced glycation end products, S100B, or purinergic signaling pathways are relevant clinical targets on EGCs with therapeutic potential.

Electronic surveys: how to maximise success.

PubMed

McPeake, Joanne; Bateson, Meghan; O'Neill, Anna

2014-01-01

To draw on the researchers' experience of developing and distributing a UK-wide electronic survey. The evolution of electronic surveys in healthcare research will be discussed, as well as simple techniques that can be used to improve response rates for this type of data collection. There is an increasing use of electronic survey methods in healthcare research. However, in recent published research, electronic surveys have had lower response rates than traditional survey methods, such as postal and telephone surveys. This is a methodology paper. Electronic surveys have many advantages over traditional surveys, including a reduction in cost and ease of analysis. Drawbacks to this type of data collection include the potential for selection bias and poorer response rates. However, research teams can use a range of simple strategies to boost response rates. These approaches target the different stages of achieving a complete response: initial attraction through personalisation, engagement by having an easily accessible link to the survey, and transparency of survey length and completion though targeting the correct, and thereby interested, population. The fast, efficient and often 'free' electronic survey has many advantages over the traditional postal data collection method, including ease of analysis for what can be vast amounts of data. However, to capitalise on these benefits, researchers must carefully consider techniques to maximise response rates and minimise selection bias for their target population. Researchers can use a range of strategies to improve responses from electronic surveys, including sending up to three reminders, personalising each email, adding the updated response rate to reminder emails, and stating the average time it would take to complete the survey in the title of the email.

The use of prophylactic antibiotics in plastic surgery: update in 2010.

PubMed

Hauck, Randy M; Nogan, Stephen

2013-01-01

The indications for prophylactic antibiotics in plastic surgery remain controversial. No recent survey has been reported on the use of prophylactic antibiotics by plastic surgeons in clinical practice. This survey was designed to assess the current use of prophylactic antibiotics by plastic surgeons and to compare trends with previous studies. All members of the American Society of Plastic Surgeons with an e-mail address on the Society's website were contacted via an e-mail and sent a link to a SurveyMonkey questionnaire. To survey only in those subspecialty areas that they practice in, surgeons were queried only on the procedures that they perform. Within each section, a list of common representative procedures was included, with questions about the use of antibiotic prophylaxis. A total of 3824 American Society of Plastic Surgeons members were contacted. Of the 3613, 910 with working e-mail addresses responded to the survey for a response rate of 25%. And 833 or 91.5% completed the survey. Survey data cover the percentage of surgeons reporting their use of antibiotics in procedures that they currently perform. The percentage of plastic surgeons who use prophylactic antibiotics in almost all procedures studied has increased significantly when compared with earlier studies. The use of prophylactic antibiotics by plastic surgeons has increased considerably since the prior studies by Krizek et al (Plast Reconstr Surg. 1975;55:21-32 and 1985;76:953-963). Some of these uses are appropriate because of the use in procedures involving implants and longer operations. The elevated rates for clean procedures are not part of the evidence-based practice.

Be Positive Be Healthe: Development and Implementation of a Targeted e-Health Weight Loss Program for Young Women.

PubMed

Hutchesson, Melinda J; Morgan, Philip J; Callister, Robin; Pranata, Ilung; Skinner, Geoff; Collins, Clare E

2016-06-01

Greater numbers of women are entering young adulthood overweight, but traditional weight loss programs do not appeal to them. This article describes the development and evaluation of an e-health weight loss intervention for young women (18-30 years of age). Young women's preferences for a targeted weight loss program were investigated via a cross-sectional online survey. A 3-month targeted weight loss program for young women was developed based on the formative research. A single-arm pre-post study was conducted to evaluate the acceptability of the intervention (process evaluation survey and objective usage data) and to estimate the treatments' effects on weight-related outcomes from baseline to 3 months. Online survey respondents (n = 274) indicated preferences for various technologies (Web site, online quizzes with e-mail feedback and goal setting, an online discussion forum, smartphone application, e-mail newsletters, and text messages). Eighteen (mean ± standard deviation [SD] age, 22.8 ± 3.2 years; body mass index, 27.3 ± 1.6 kg/m(2)) women entered the pre-post study. Mean satisfaction was 3.4 ± 1.0 (maximum of 5), and 66.7% of participants completed the study. Significant reductions in mean ± SD weight (-1.5 ± 2.4 kg; p = 0.02) and waist circumference (-0.7 ± 1.4 cm; p = 0.04) were observed. Due to lower than anticipated participant satisfaction, modifications to the program content and modes of delivery are required to ensure a higher proportion of young women complete and actively engage with the program. The positive effects of treatment on weight-related outcomes supports further refinement and evaluation of targeted, e-health weight loss interventions for young women.

Transcriptional Profiling of Metabolic Transitions during Development and Diapause Preparation in the Copepod Calanus finmarchicus.

PubMed

Tarrant, Ann M; Baumgartner, Mark F; Lysiak, Nadine S J; Altin, Dag; Størseth, Trond R; Hansen, Bjørn Henrik

2016-12-01

Calanus finmarchicus, like many other copepods in the family Calanidae, can enter into a facultative diapause during the last juvenile phase (fifth copepodid, C5) to enable survival during unfavorable periods. Diapause is essential to the persistence of Calanus populations and profoundly impacts energy flow within oceanic ecosystems, yet regulation of diapause is not understood in these animals. Transcriptional profiling has begun to provide insight into metabolic changes occurring as C. finmarchicus prepares for and enters into diapause or skips diapause to prepare for the terminal molt. In particular, components of the glycolysis, pentose phosphate and lipid synthesis pathways are upregulated early in the C5 stage when lipid stores are low. Currently, our ability to identify metabolic patterns is limited by the incomplete functional annotation of the C. finmarchicus transcriptome. Such limitations are widespread among studies of non-model organisms and addressing them should be a priority for future research. In addition, integrating the results across multiple emerging complementary transcriptomic studies will provide a more complete picture of copepod physiology than isolated studies. Ultimately, identifying molecular markers of copepod physiology could enable robust identification of animals preparing to enter into diapause and ultimately lead to a greatly improved understanding of diapause regulation. © The Author 2016. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice.

PubMed

DeCoffe, Daniella; Quin, Candice; Gill, Sandeep K; Tasnim, Nishat; Brown, Kirsty; Godovannyi, Artem; Dai, Chuanbin; Abulizi, Nijiati; Chan, Yee Kwan; Ghosh, Sanjoy; Gibson, Deanna L

2016-06-01

Dietary lipids modulate immunity, yet the means by which specific fatty acids affect infectious disease susceptibility remains unclear. Deciphering lipid-induced immunity is critical to understanding the balance required for protecting against pathogens while avoiding chronic inflammatory diseases. To understand how specific lipids alter susceptibility to enteric infection, we fed mice isocaloric, high-fat diets composed of corn oil (rich in n-6 polyunsaturated fatty acids [n-6 PUFAs]), olive oil (rich in monounsaturated fatty acids), or milk fat (rich in saturated fatty acids) with or without fish oil (rich in n-3 PUFAs). After 5 weeks of dietary intervention, mice were challenged with Citrobacter rodentium, and pathological responses were assessed. Olive oil diets resulted in little colonic pathology associated with intestinal alkaline phosphatase, a mucosal defense factor that detoxifies lipopolysaccharide. In contrast, while both corn oil and milk fat diets resulted in inflammation-induced colonic damage, only milk fat induced compensatory protective responses, including short chain fatty acid production. Fish oil combined with milk fat, unlike unsaturated lipid diets, had a protective effect associated with intestinal alkaline phosphatase activity. Overall, these results reveal that dietary lipid type, independent of the total number of calories associated with the dietary lipid, influences the susceptibility to enteric damage and the benefits of fish oil during infection. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

The Use of Technology in Participant Tracking and Study Retention: Lessons Learned From a Clinical Trials Network Study.

PubMed

Mitchell, Shannon Gwin; Schwartz, Robert P; Alvanzo, Anika A H; Weisman, Monique S; Kyle, Tiffany L; Turrigiano, Eva M; Gibson, Martha L; Perez, Livangelie; McClure, Erin A; Clingerman, Sara; Froias, Autumn; Shandera, Danielle R; Walker, Robrina; Babcock, Dean L; Bailey, Genie L; Miele, Gloria M; Kunkel, Lynn E; Norton, Michael; Stitzer, Maxine L

2015-01-01

The growing use of newer communication and Internet technologies, even among low-income and transient populations, require research staff to update their outreach strategies to ensure high follow-up and participant retention rates. This paper presents the views of research assistants on the use of cell phones and the Internet to track participants in a multisite randomized trial of substance use disorder treatment. Preinterview questionnaires exploring tracking and other study-related activities were collected from 21 research staff across the 10 participating US sites. Data were then used to construct a semistructured interview guide that, in turn, was used to interview 12 of the same staff members. The questionnaires and interview data were entered in Atlas.ti and analyzed for emergent themes related to the use of technology for participant-tracking purposes. Study staff reported that most participants had cell phones, despite having unstable physical addresses and landlines. The incoming call feature of most cell phones was useful for participants and research staff alike, and texting proved to have additional benefits. However, reliance on participants' cell phones also proved problematic. Even homeless participants were found to have access to the Internet through public libraries and could respond to study staff e-mails. Some study sites opened generic social media accounts, through which study staff sent private messages to participants. However, the institutional review board (IRB) approval process for tracking participants using social media at some sites was prohibitively lengthy. Internet searches through Google, national paid databases, obituaries, and judiciary Web sites were also helpful tools. Research staff perceive that cell phones, Internet searches, and social networking sites were effective tools to achieve high follow-up rates in drug abuse research. Studies should incorporate cell phone, texting, and social network Web site information on locator forms; obtain IRB approval for contacting participants using social networking Web sites; and include Web searches, texting, and the use of social media in staff training as standard operating procedures.

Enteroaggregative Escherichia coli: An Emerging Enteric Food Borne Pathogen

PubMed Central

Kaur, P.; Chakraborti, A.; Asea, A.

2010-01-01

Enteroaggregative Escherichia coli (EAEC) are quite heterogeneous category of an emerging enteric pathogen associated with cases of acute or persistent diarrhea worldwide in children and adults, and over the past decade has received increasing attention as a cause of watery diarrhea, which is often persistent. EAEC infection is an important cause of diarrhea in outbreak and non-outbreak settings in developing and developed countries. Recently, EAEC has been implicated in the development of irritable bowel syndrome, but this remains to be confirmed. EAEC is defined as a diarrheal pathogen based on its characteristic aggregative adherence (AA) to HEp-2 cells in culture and its biofilm formation on the intestinal mucosa with a “stacked-brick” adherence phenotype, which is related to the presence of a 60 MDa plasmid (pAA). At the molecular level, strains demonstrating the aggregative phenotype are quite heterogeneous; several virulence factors are detected by polymerase chain reaction; however, none exhibited 100% specificity. Although several studies have identified specific virulence factor(s) unique to EAEC, the mechanism by which EAEC exerts its pathogenesis is, thus, far unknown. The present review updates the current knowledge on the epidemiology, chronic complications, detection, virulence factors, and treatment of EAEC, an emerging enteric food borne pathogen. PMID:20300577

Trust in health Websites: a survey among Norwegian Internet users.

PubMed

Rosenvinge, Jan H; Laugerud, Stein; Hjortdahl, Per

2003-01-01

Whether consumers feel able to trust the information presented on a health-related Website is as important a quality criterion as more objective criteria. We investigated whether trust was related to five aspects of health Websites: the involvement of health professionals, a facility for interactive communication, information about those responsible for the site, a picture of those responsible for the site, and the impression of site update frequency. A polling agency invited, by email, a sample of 600 Norwegian users of e-health information to participate in the study and 476 subjects did so (a 79% response rate), by completing a questionnaire online. Their mean age was 41 years and 53% were female. All five aspects of health Websites were related to the trust placed in the site but they were not consistently related to gender or age. Trust in Websites that were frequently updated was related to being a frequent e-health user, while those who trusted interactive e-health sites were low-frequency users who tended to order drugs and health products from the sites. The probability of taking action as a result of e-health information was related to the frequency of visits to health Websites but not to the five aspects of them investigated in relation to trust. However, respondents who trusted sites that were perceived as being frequently updated and to have health professionals involved were more likely to be frequent users of e-health information.

Update on the MiniCLEAN dark matter experiment

DOE PAGES

Rielage, K.; Akashi-Ronquest, M.; Bodmer, M.; ...

2015-03-24

The direct search for dark matter is entering a period of increased sensitivity to the hypothetical Weakly Interacting Massive Particle (WIMP). One such technology that is being examined is a scintillation only noble liquid experiment, MiniCLEAN. MiniCLEAN utilizes over 500 kg of liquid cryogen to detect nuclear recoils from WIMP dark matter and serves as a demonstration for a future detector of order 50 to 100 tonnes. The liquid cryogen is interchangeable between argon and neon to study the A² dependence of the potential signal and examine backgrounds. MiniCLEAN utilizes a unique modular design with spherical geometry to maximize themore » light yield using cold photomultiplier tubes in a single-phase detector. Pulse shape discrimination techniques are used to separate nuclear recoil signals from electron recoil backgrounds. MiniCLEAN will be spiked with additional ³⁹Ar to demonstrate the effective reach of the pulse shape discrimination capability. Assembly of the experiment is underway at SNOLAB and an update on the project is given.« less

Extremum seeking with bounded update rates

DOE PAGES

Scheinker, Alexander; Krstić, Miroslav

2013-11-16

In this work, we present a form of extremum seeking (ES) in which the unknown function being minimized enters the system’s dynamics as the argument of a cosine or sine term, thereby guaranteeing known bounds on update rates and control efforts. We present general n-dimensional optimization and stabilization results as well as 2D vehicle control, with bounded velocity and control efforts. For application to autonomous vehicles, tracking a source in a GPS denied environment with unknown orientation, this ES approach allows for smooth heading angle actuation, with constant velocity, and in application to a unicycle-type vehicle results in control abilitymore » as if the vehicle is fully actuated. Our stability analysis is made possible by the classic results of Kurzweil, Jarnik, Sussmann, and Liu, regarding systems with highly oscillatory terms. In our stability analysis, we combine the averaging results with a semi-global practical stability result under small parametric perturbations developed by Moreau and Aeyels.« less

Gastroparesis Updates on Pathogenesis and Management

PubMed Central

Liu, Nanlong; Abell, Thomas

2017-01-01

Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This article focuses on updates in the pathogenesis and management of Gp. Recent studies on full thickness biopsies of Gp patients have shed light on the complex interactions of the central, autonomic, and enteric nervous systems, which all play key roles in maintaining normal gut motility. The management of Gp has evolved beyond prokinetics and antiemetics with the use of gastric electrical stimulators (GES). In addition, this review aims to introduce the concept of gastroparesis-like syndrome (GLS). GLS helps groups of patients who have the cardinal symptoms of Gp but have a normal or rapid emptying test. Recent tests have shown that patients with Gp and GLS have similar pathophysiology, benefit greatly from GES placement, and likely should be treated in a similar manner. PMID:28535580

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5 ...

EPA Pesticide Factsheets

On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the charge to external peer reviewers, are posted on this site. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for RDX. The outcome of this project is an updated Toxicological Review and IRIS Summary for RDX that will be entered into the IRIS database.

Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework.

PubMed

Kosek, Margaret; Guerrant, Richard L; Kang, Gagandeep; Bhutta, Zulfiqar; Yori, Pablo Peñataro; Gratz, Jean; Gottlieb, Michael; Lang, Dennis; Lee, Gwenyth; Haque, Rashidul; Mason, Carl J; Ahmed, Tahmeed; Lima, Aldo; Petri, William A; Houpt, Eric; Olortegui, Maribel Paredes; Seidman, Jessica C; Mduma, Estomih; Samie, Amidou; Babji, Sudhir

2014-11-01

Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Address entry while driving: speech recognition versus a touch-screen keyboard.

PubMed

Tsimhoni, Omer; Smith, Daniel; Green, Paul

2004-01-01

A driving simulator experiment was conducted to determine the effects of entering addresses into a navigation system during driving. Participants drove on roads of varying visual demand while entering addresses. Three address entry methods were explored: word-based speech recognition, character-based speech recognition, and typing on a touch-screen keyboard. For each method, vehicle control and task measures, glance timing, and subjective ratings were examined. During driving, word-based speech recognition yielded the shortest total task time (15.3 s), followed by character-based speech recognition (41.0 s) and touch-screen keyboard (86.0 s). The standard deviation of lateral position when performing keyboard entry (0.21 m) was 60% higher than that for all other address entry methods (0.13 m). Degradation of vehicle control associated with address entry using a touch screen suggests that the use of speech recognition is favorable. Speech recognition systems with visual feedback, however, even with excellent accuracy, are not without performance consequences. Applications of this research include the design of in-vehicle navigation systems as well as other systems requiring significant driver input, such as E-mail, the Internet, and text messaging.

Draft genome sequence and annotation of Lactobacillus acetotolerans BM-LA14527, a beer-spoilage bacteria.

PubMed

Liu, Junyan; Li, Lin; Peters, Brian M; Li, Bing; Deng, Yang; Xu, Zhenbo; Shirtliff, Mark E

2016-09-01

Lactobacillus acetotolerans is a hard-to-culture beer-spoilage bacterium capable of entering into the viable putative nonculturable (VPNC) state. As part of an initial strategy to investigate the phenotypic behavior of L. acetotolerans, draft genome sequencing was performed. Results demonstrated a total of 1824 predicted annotated genes, with several potential VPNC- and beer-spoilage-associated genes identified. Importantly, this is the first genome sequence of L. acetotolerans as beer-spoilage bacteria and it may aid in further analysis of L. acetotolerans and other beer-spoilage bacteria, with direct implications for food safety control in the beer brewing industry. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MODFLOW-2000, the U.S. Geological Survey modular ground-water model -- Documentation of MOD-PREDICT for predictions, prediction sensitivity analysis, and evaluation of uncertainty

USGS Publications Warehouse

Tonkin, M.J.; Hill, Mary C.; Doherty, John

2003-01-01

This document describes the MOD-PREDICT program, which helps evaluate userdefined sets of observations, prior information, and predictions, using the ground-water model MODFLOW-2000. MOD-PREDICT takes advantage of the existing Observation and Sensitivity Processes (Hill and others, 2000) by initiating runs of MODFLOW-2000 and using the output files produced. The names and formats of the MODFLOW-2000 input files are unchanged, such that full backward compatibility is maintained. A new name file and input files are required for MOD-PREDICT. The performance of MOD-PREDICT has been tested in a variety of applications. Future applications, however, might reveal errors that were not detected in the test simulations. Users are requested to notify the U.S. Geological Survey of any errors found in this document or the computer program using the email address available at the web address below. Updates might occasionally be made to this document, to the MOD-PREDICT program, and to MODFLOW- 2000. Users can check for updates on the Internet at URL http://water.usgs.gov/software/ground water.html/.

THE NRPI MULTI-PURPOSE ON-LINE MONITORING STATION FOR MEASUREMENT OF NATURAL RADIOACTIVITY IN THE AMBIENT ATMOSPHERE AND IN THE SOIL.

PubMed

Jílek, K; Slezáková, M; Fronka, A; Prokop, T; Neubauer, L

2017-11-01

During years 2010-12 an automated, on-line and wireless outdoor measurement station of atmospheric radon, gamma dose rate and meteorological parameters was realised at the National Radiation Protection Institute (NRPI) in Prague. At the turn of the year 2013 an expansion of the existing station was completed. Under the project funded by the Czech Technological Agency a new updated station was established, additionally equipped with modules for measurement of atmospheric radon/thoron short-lived decay products, radon in water and soil and radon exhalation rate from soil. After the introduction of the station updated key detection parameters and benefits, its use for atmospheric modelling and monitoring is demonstrated. There are summarised results from the 3-year measurement period in the NRPI outdoor area in Prague and from simultaneous annual measurement performed by another similar station located near uranium mud fields in DIAMO, state enterprise, Stráž pod Ralskem. Observed seasonal and diurnal variations of atmospheric radon concentrations and variability of the equilibrium factor, F, are illustrated and compared. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies to Control Antimicrobial Resistance From Food Animal Production.

PubMed

Collignon, Peter C; Conly, John M; Andremont, Antoine; McEwen, Scott A; Aidara-Kane, Awa; Agerso, Yvonne; Andremont, Antoine; Collignon, Peter; Conly, John; Dang Ninh, Tran; Donado-Godoy, Pilar; Fedorka-Cray, Paula; Fernandez, Heriberto; Galas, Marcelo; Irwin, Rebecca; Karp, Beth; Matar, Gassan; McDermott, Patrick; McEwen, Scott; Mitema, Eric; Reid-Smith, Richard; Scott, H Morgan; Singh, Ruby; DeWaal, Caroline Smith; Stelling, John; Toleman, Mark; Watanabe, Haruo; Woo, Gun-Jo

2016-10-15

Antimicrobial use in food animals selects for antimicrobial resistance in bacteria, which can spread to people. Reducing use of antimicrobials-particularly those deemed to be critically important for human medicine-in food production animals continues to be an important step for preserving the benefits of these antimicrobials for people. The World Health Organization ranking of antimicrobials according to their relative importance in human medicine was recently updated. Antimicrobials considered the highest priority among the critically important antimicrobials were quinolones, third- and fourth-generation cephalosporins, macrolides and ketolides, and glycopeptides. The updated ranking allows stakeholders in the agriculture sector and regulatory agencies to focus risk management efforts on drugs used in food animals that are the most important to human medicine. In particular, the current large-scale use of fluoroquinolones, macrolides, and third-generation cephalosporins and any potential use of glycopeptides and carbapenems need to be addressed urgently. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Assessing the professional development needs of public health educators in light of changing competencies.

PubMed

Demers, Anne Roesler; Mamary, Edward

2008-10-01

Because of the need for a well-trained public health workforce, professional competencies have been recently revised by the Institute of Medicine and the National Health Educator Competencies Update Project. This study compared the self-identified training needs of public health educators with the updated competencies and assessed employer support for continuing education. A convenience sample of public health educators was recruited from an e-mail list of San Jose State University master of public health alumni. Respondents completed a Web-based survey that elicited information on emerging trends in public health education, training needs, and employer support for continuing education. Concerns about funding cuts and privatization of resources emerged as a theme. Key trends reported were an increase in information technology, the need for policy advocacy skills, and the importance of a lifespan approach to health issues. Primary areas for training were organization development, evaluation, and management. Although most employers were reported to support continuing education, less than two-thirds of respondents were reimbursed for expenses. These findings have implications for both research and practice. Innovative technologies should be developed to address health education professionals' training needs, and emerging themes should be incorporated into curricula for students.

Neurological Disorders in Medical Use of Cannabis: An Update.

PubMed

Solimini, Renata; Rotolo, Maria Concetta; Pichini, Simona; Pacifici, Roberta

2017-01-01

Medical cannabis is increasingly used as a treatment or adjunct treatment with different levels of efficacy in several neurological disorders or related symptoms (such as multiple sclerosis, autism, Parkinson and Alzheimer disease, Tourette's syndrome, Huntington's disease, neuropathic pain, epilepsy, headache), as well as in other medical conditions (e.g. nausea and vomiting, glaucoma, appetite stimulation, cancer, inflammatory conditions, asthma). Nevertheless, a number of neurological adverse effects from use of medical cannabis on the short- and on the longterm have been reported, in addition to other adverse health events. It has been noticed that the use of medical cannabis can lead to a paradoxical effects depending on the amount of delta-9-tetrahydrocannabinol (THC) -like cannabinoids the preparation contain. Accordingly, some neurological disorders or symptoms (e.g. multiple sclerosis, seizures, epilepsy, headache) may be caused or exacerbated by the same treatment supposed to cure them. The current review presents an update of the neurological adverse effects resulting from the use of cannabis for medical purposes, highlighting the need to weigh the benefits and risks, when using cannabinoidbased treatments. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Who is teaching what, when? An evolving online tool to manage dental curricula.

PubMed

Walton, Joanne N

2014-03-01

There are numerous issues in the documentation and ongoing development of health professions curricula. It seems that curriculum information falls quickly out of date between accreditation cycles, while students and faculty members struggle in the meantime with the "hidden curriculum" and unintended redundancies and gaps. Beyond knowing what is in the curriculum lies the frustration of timetabling learning in a transparent way while allowing for on-the-fly changes and improvements. The University of British Columbia Faculty of Dentistry set out to develop a curriculum database to answer the simple but challenging question "who is teaching what, when?" That tool, dubbed "OSCAR," has evolved to not only document the dental curriculum, but as a shared instrument that also holds the curricula and scheduling detail of the dental hygiene degree and clinical graduate programs. In addition to providing documentation ranging from reports for accreditation to daily information critical to faculty administrators and staff, OSCAR provides faculty and students with individual timetables and pushes updates via text, email, and calendar changes. It incorporates reminders and session resources for students and can be updated by both faculty members and staff. OSCAR has evolved into an essential tool for tracking, scheduling, and improving the school's curricula.

Normal Aging of the Attentional Control Functions That Underlie Working Memory.

PubMed

Sylvain-Roy, Stéphanie; Lungu, Ovidiu; Belleville, Sylvie

2015-09-01

This study assessed the effect of aging on 3 attentional control functions (ACFs)--shifting, inhibition, and updating--and on their contribution to working memory (WM) tasks. Complex WM tasks (the Brown-Peterson procedure, the reading span, and the alpha span) and tasks used to derive composite measures of the ACFs were administered to 75 younger and 75 older adults. Of the 3 ACFs, only inhibition was impaired in aging after controlling for processing speed. Furthermore, the effect of aging on WM tasks was not pervasive, as older adults showed impaired performance on the Brown-Peterson procedure and the reading span but not on the alpha span. When examining the contribution of ACFs to WM in older adults, updating accounted for performance on the Brown-Peterson and reading span tasks, and inhibition was involved in performance on the alpha span task. In younger adults, it was processing speed that contributed the most to WM. This pattern of results suggests that complex WM tasks reflect different ACFs and that this varies as a function of age. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Update of Standard Practices for New Method Validation in Forensic Toxicology.

PubMed

Wille, Sarah M R; Coucke, Wim; De Baere, Thierry; Peters, Frank T

2017-01-01

International agreement concerning validation guidelines is important to obtain quality forensic bioanalytical research and routine applications as it all starts with the reporting of reliable analytical data. Standards for fundamental validation parameters are provided in guidelines as those from the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), the German speaking Gesellschaft fur Toxikologie und Forensische Chemie (GTFCH) and the Scientific Working Group of Forensic Toxicology (SWGTOX). These validation parameters include selectivity, matrix effects, method limits, calibration, accuracy and stability, as well as other parameters such as carryover, dilution integrity and incurred sample reanalysis. It is, however, not easy for laboratories to implement these guidelines into practice as these international guidelines remain nonbinding protocols, that depend on the applied analytical technique, and that need to be updated according the analyst's method requirements and the application type. In this manuscript, a review of the current guidelines and literature concerning bioanalytical validation parameters in a forensic context is given and discussed. In addition, suggestions for the experimental set-up, the pros and cons of statistical approaches and adequate acceptance criteria for the validation of bioanalytical applications are given. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

National Utility Rate Database: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ong, S.; McKeel, R.

2012-08-01

When modeling solar energy technologies and other distributed energy systems, using high-quality expansive electricity rates is essential. The National Renewable Energy Laboratory (NREL) developed a utility rate platform for entering, storing, updating, and accessing a large collection of utility rates from around the United States. This utility rate platform lives on the Open Energy Information (OpenEI) website, OpenEI.org, allowing the data to be programmatically accessed from a web browser, using an application programming interface (API). The semantic-based utility rate platform currently has record of 1,885 utility rates and covers over 85% of the electricity consumption in the United States.

The usefulness of handheld computers in a surgical group practice.

PubMed Central

Blackman, J.; Gorman, P.; Lohensohn, R.; Kraemer, D.; Svingen, S.

1999-01-01

We designed a system using hand-held computers allowing physicians in the hospital setting to access their surgical schedules, to track patients in multiple hospitals, and to quickly enter billing information. The physicians would then update their schedules and pass billing information electronically when they returned to the office. The system was successfully implemented, it was well accepted by clinicians and staff users, and it showed an increased capture of charges. Whether an economically important effect on the number of days to post hospital charges will be evident after follow-up data has been collected. PMID:10566447

Global crowd data to understand risk taking behavior: Understanding the costs of crowd sourcing

NASA Astrophysics Data System (ADS)

Hendrikx, J.; Johnson, J.

2016-12-01

Crowd sourcing is an increasingly common approach to collect data from a large number of places, people, or both, for a given phenomenon or observation. It is often thought of as a very cost effective approach to collect data from large spatial domains, or from difficult to reach areas, or for spatially discrete observations. While crowd sourcing data can provide a wealth of data beyond that which most research teams can collect themselves, there are many associated, and sometime unexpected costs with this approach. We present a case study of a crowd-sourced data collection campaign to collect GPS tracks of back country recreationalists in avalanche terrain. We ask the volunteers to track their outings using the GPS on their smart phone using a free application, and on the completion of their trip email us their track. On receipt of this track we automatically reply with a link to a decision making survey. In this way we collect data on both the physical attributes of their trip, as well as the social, psychological and demographic data about the person. While this approach has been very successful, it has come at a high cost time-wise. Much like the role of an online course instructor, instructor (or in this case researcher) presence is essential. Replying to emails, updating webpages, posting on social media, and connecting with your volunteer data collectors can become a full time job - and that's even before you start the data analysis. We encourage future researchers to plan ahead for this when starting a crowd sourcing project involving the general public, and seek advice and training in social media, web site development and communication techniques like semi-automated email.

Physician assessments of the value of therapeutic information delivered via e-mail

PubMed Central

Grad, Roland; Pluye, Pierre; Repchinsky, Carol; Jovaisas, Barbara; Marlow, Bernard; Marques Ricarte, Ivan L.; Galvão, Maria Cristiane Barbosa; Shulha, Michael; de Gaspé Bonar, James

2014-01-01

Abstract Problem addressed Although e-learning programs are popular and access to electronic knowledge resources has improved, raising awareness about updated therapeutic recommendations in practice continues to be a challenge. Objective of program To raise awareness about and document the use of therapeutic recommendations. Program description In 2010, family physicians evaluated e-Therapeutics (e-T) Highlights with a Web-based tool called the Information Assessment Method (IAM). The e-T Highlights consisted of information found in the primary care reference e-Therapeutics+. Each week, family physicians received an e-mail containing a link to 1 Highlight from a different chapter of e-Therapeutics+. Family physicians received continuing medical education credits for each Highlight they rated with the IAM. Of the 5346 participants, 85% of them were full-time or part-time practitioners. A total of 31 429 Highlights ratings were received in 2010 (median of 2 ratings per participant, range 1 to 49). Among participants who rated more than 2 Highlights, the median number of ratings was 7 (mean 11.9). The relevance of the information from individual Highlights varied widely; however, for 90% of the rated Highlights participants indicated total or partial relevance of the information for at least 1 patient. For 41% of rated Highlights, participants expected patient health benefits to result from implementing the recommendation, such as avoiding an unnecessary or inappropriate treatment, or a preventive intervention. Conclusion This continuing medical education program stimulated family physicians to rate therapeutic recommendations that were delivered weekly via e-mail. The process of rating e-T Highlights with the IAM raised awareness about treatment recommendations and documented self-reported use of this information in practice. PMID:24829020

Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity.

PubMed

Pápay, Zsófia Edit; Kállai-Szabó, Nikolett; Balogh, Emese; Ludányi, Krisztina; Klebovich, Imre; Antal, István

2017-01-01

Drug delivery of phytochemicals has gained interest recently due to their remarkable health effects. Apigenin, a plant flavonoid, has antioxidant, anti-inflammatory and anticancer activities but its delivery is challenging. It could be absorbed through the whole intestine, however, it has poor bioavailability due to its low aqueous solubility. In Europe, the daily intake was estimated to be as low as 3 ± 1 mg. Pellets offer several advantages such as improved bioavailability and various resultant drug release profiles can be obtained by simply mixing pellets with different coatings. The objective of our study was to develop a carrier system containing 20 mg apigenin thus enhancing intake and to offer reduction of oxidative stress which can cause inflammation in the intestine. The apigenin powder was dispersed in aqueous solution of binding material and layered onto the inert cores in a fluidized bed apparatus. The layered cores were further coated with enteric polymers and the process parameters were optimized. The prepared pellets met with the requirements and have good physical characteristic. 10% (w/w) Eudragit® L was suitable for enteric coating with a complete release at pH 6.8 within 1 hour. 15% (w/w) Eudragit® FS coating ensured acid resistance ability and colonic delivery. The therapeutic efficiency was confirmed with antioxidant activity measurement by using DPPH* assay. Enteric coated spheres allow targeted delivery into the intestine and colon thus reaching the main absorption site. Pellets were proved to be an optimal delivery system for apigenin thus providing enhanced apigenin intake. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

An integrated database on ticks and tick-borne zoonoses in the tropics and subtropics with special reference to developing and emerging countries.

PubMed

Vesco, Umberto; Knap, Nataša; Labruna, Marcelo B; Avšič-Županc, Tatjana; Estrada-Peña, Agustín; Guglielmone, Alberto A; Bechara, Gervasio H; Gueye, Arona; Lakos, Andras; Grindatto, Anna; Conte, Valeria; De Meneghi, Daniele

2011-05-01

Tick-borne zoonoses (TBZ) are emerging diseases worldwide. A large amount of information (e.g. case reports, results of epidemiological surveillance, etc.) is dispersed through various reference sources (ISI and non-ISI journals, conference proceedings, technical reports, etc.). An integrated database-derived from the ICTTD-3 project ( http://www.icttd.nl )-was developed in order to gather TBZ records in the (sub-)tropics, collected both by the authors and collaborators worldwide. A dedicated website ( http://www.tickbornezoonoses.org ) was created to promote collaboration and circulate information. Data collected are made freely available to researchers for analysis by spatial methods, integrating mapped ecological factors for predicting TBZ risk. The authors present the assembly process of the TBZ database: the compilation of an updated list of TBZ relevant for (sub-)tropics, the database design and its structure, the method of bibliographic search, the assessment of spatial precision of geo-referenced records. At the time of writing, 725 records extracted from 337 publications related to 59 countries in the (sub-)tropics, have been entered in the database. TBZ distribution maps were also produced. Imported cases have been also accounted for. The most important datasets with geo-referenced records were those on Spotted Fever Group rickettsiosis in Latin-America and Crimean-Congo Haemorrhagic Fever in Africa. The authors stress the need for international collaboration in data collection to update and improve the database. Supervision of data entered remains always necessary. Means to foster collaboration are discussed. The paper is also intended to describe the challenges encountered to assemble spatial data from various sources and to help develop similar data collections.

Effects of an Updated Preventive Home Visit Program Based on a Systematic Structured Assessment of Care Needs for Ambulatory Frail Older Adults in Japan: A Randomized Controlled Trial.

PubMed

Kono, Ayumi; Izumi, Kyoko; Yoshiyuki, Noriko; Kanaya, Yukiko; Rubenstein, Laurence Z

2016-12-01

The aim of this randomized controlled trial was to determine the effects on functional parameters of an updated preventive home visit program for frail older adults in the Japanese Long-term Care Insurance (LTCI) system. The program included home visits by nurses or care managers every 3 months for 24 months, with a systematic assessment of care needs to prevent functional decline. Eligible participants (N = 360) were randomly assigned to the visit (VG: n = 179) or control group (CG: n = 181). Functional parameters were gathered via mail questionnaires at baseline and at 12- and 24-month follow-ups. Care-need levels in the LTCI were obtained at 12-, 24-, and 36-month follow-ups and the utilization of the LTCI service through 36 months. Participants in VG were significantly more likely to maintain their activities of daily living (ADL) functioning (p = .0113) and less likely to increase care-needs level, compared with CG participants, over 24 months. A generalized linear model showed that the estimate of the effect on increase in care-needs level (ie, functional decline) was -0.53 (p = .042) over 36 months. These results suggest that the updated preventive home visit program could be effective for the prevention of ADL and care-needs deterioration, and these effects could continue up to 1 year after program completion. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Tecemotide in unresectable stage III non-small-cell lung cancer in the phase III START study: updated overall survival and biomarker analyses.

PubMed

Mitchell, P; Thatcher, N; Socinski, M A; Wasilewska-Tesluk, E; Horwood, K; Szczesna, A; Martín, C; Ragulin, Y; Zukin, M; Helwig, C; Falk, M; Butts, C; Shepherd, F A

2015-06-01

Tecemotide is a MUC1-antigen-specific cancer immunotherapy. The phase III START study did not meet its primary end point but reported notable survival benefit with tecemotide versus placebo in an exploratory analysis of the predefined patient subgroup treated with concurrent chemoradiotherapy. Here, we attempted to gain further insight into the effects of tecemotide in START. START recruited patients who did not progress following frontline chemoradiotherapy for unresectable stage III non-small-cell lung cancer. We present updated overall survival (OS) data and exploratory analyses of OS for baseline biomarkers: soluble MUC1 (sMUC1), antinuclear antibodies (ANA), neutrophil/lymphocyte ratio (NLR), lymphocyte count, and HLA type. Updated OS data are consistent with the primary analysis: median 25.8 months (tecemotide) versus 22.4 months (placebo) (HR 0.89, 95% CI 0.77-1.03, P = 0.111), with ∼20 months additional median follow-up time compared with the primary analysis. Exploratory analysis of the predefined subgroup treated with concurrent chemoradiotherapy revealed clinically relevant prolonged OS with tecemotide versus placebo (29.4 versus 20.8 months; HR 0.81, 95% CI 0.68-0.98, P = 0.026). No improvement was seen with sequential chemoradiotherapy. High sMUC1 and ANA correlated with a possible survival benefit with tecemotide (interaction P = 0.0085 and 0.0022) and might have future value as biomarkers. Interactions between lymphocyte count, NLR, or prespecified HLA alleles and treatment effect were not observed. Updated OS data support potential treatment benefit with tecemotide in patients treated with concurrent chemoradiotherapy. Exploratory biomarker analyses suggest that elevated sMUC1 or ANA levels correlate with tecemotide benefit. NCT00409188. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

New Directions in the NOAO Observing Proposal System

NASA Astrophysics Data System (ADS)

Gasson, David; Bell, Dave

For the past eight years NOAO has been refining its on-line observing proposal system. Virtually all related processes are now handled electronically. Members of the astronomical community can submit proposals through email, web form, or via the Gemini Phase I Tool. NOAO staff can use the system to do administrative tasks, scheduling, and compilation of various statistics. In addition, all information relevant to the TAC process is made available on-line, including the proposals themselves (in HTML, PDF and PostScript) and technical comments. Grades and TAC comments are entered and edited through web forms, and can be sorted and filtered according to specified criteria. Current developments include a move away from proprietary solutions, toward open standards such as SQL (in the form of the MySQL relational database system), Perl, PHP and XML.

Living in the electronic age: musings on nearly two decades in Cyberspace.

PubMed

Gavrin, Jonathan R

2009-01-01

My journey through Cyberspace began about 20 years ago with an introduction to e-mail. A few years later, I had the good fortune of working with artificial intelligence engineers who were developing information retrieval techniques and expert systems. By serendipity this led to an early introduction to the World Wide Web (www) and the use of Web browsers as tools for gathering information, long before the Internet became commercialized. Internet content and form are now so omnipresent that they have affected our language in both amusing and utilitarian ways. We are entering an era where social networking, from personal to professional lives, is potentially a vibrant new direction for the Internet. Future articles for this feature will explore how to maximize the utility of the Internet.

Updates of Topical and Local Anesthesia Agents.

PubMed

Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

2016-04-01

As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. Copyright © 2016 Elsevier Inc. All rights reserved.

Biased Metropolis Sampling for Rugged Free Energy Landscapes

NASA Astrophysics Data System (ADS)

Berg, Bernd A.

2003-11-01

Metropolis simulations of all-atom models of peptides (i.e. small proteins) are considered. Inspired by the funnel picture of Bryngelson and Wolyness, a transformation of the updating probabilities of the dihedral angles is defined, which uses probability densities from a higher temperature to improve the algorithmic performance at a lower temperature. The method is suitable for canonical as well as for generalized ensemble simulations. A simple approximation to the full transformation is tested at room temperature for Met-Enkephalin in vacuum. Integrated autocorrelation times are found to be reduced by factors close to two and a similar improvement due to generalized ensemble methods enters multiplicatively.

SAMICS: Input data preparation. [Solar Array Manufacturing Industry Costing Standards

NASA Technical Reports Server (NTRS)

Chamberlain, R. G.; Aster, R. W.

1979-01-01

The Solar Array Manufacturing Industry Costing Standards (SAMICS) provide standard formats, data, assumptions, and procedures for estimating the price that a manufacturer would have to charge for the product of a specified manufacturing process sequence. A line-by-line explanation is given of those standard formats which describe the economically important characteristics of the manufacturing processes and the technological structure of the companies and the industry. This revision provides an updated presentation of Format A Process Description, consistent with the October 1978 version of that form. A checklist of items which should be entered on Format A as direct expenses is included.

Striving for Gender Equity in Academic Medicine Careers: A Call to Action

PubMed Central

Bates, Carol; Gordon, Lynn; Travis, Elizabeth; Chatterjee, Archana; Chaudron, Linda; Fivush, Barbara; Gulati, Martha; Jagsi, Reshma; Sharma, Poonam; Gillis, Marin; Ganetzky, Rebecca; Grover, Amelia; Lautenberger, Diana; Moses, Ashleigh

2018-01-01

Women represent approximately half of students entering medical schools and more than half of those entering PhD programs. When advancing through the academic and professional fields, however, women continually face barriers that men do not. In this Commentary, the authors offer ideas for coordinating the efforts of organizations, academic institutions, and leaders throughout the scientific and medical professions to reduce barriers that result in inequities and, instead, strive for gender parity. Specific areas of focus outlined by the authors include facilitating women’s access to formal and informal professional networks, acknowledging and addressing the gender pay gap as well as the lack of research funding awarded to women in the field, and updating workplace policies that have not evolved to accommodate women’s lifestyles. As academic institutions seek access to top talent and the means to develop those individuals capable of generating the change medicine and science needs, the authors urge leaders and change agents within academic medicine to address the systemic barriers to gender equity that impede us from achieving the mission to improve the health of all. PMID:27332868

Striving for Gender Equity in Academic Medicine Careers: A Call to Action.

PubMed

Bates, Carol; Gordon, Lynn; Travis, Elizabeth; Chatterjee, Archana; Chaudron, Linda; Fivush, Barbara; Gulati, Martha; Jagsi, Reshma; Sharma, Poonam; Gillis, Marin; Ganetzky, Rebecca; Grover, Amelia; Lautenberger, Diana; Moses, Ashleigh

2016-08-01

Women represent approximately half of students entering medical schools and more than half of those entering PhD programs. When advancing through the academic and professional fields, however, women continually face barriers that men do not. In this Commentary, the authors offer ideas for coordinating the efforts of organizations, academic institutions, and leaders throughout the scientific and medical professions to reduce barriers that result in inequities and, instead, strive for gender parity. Specific areas of focus outlined by the authors include facilitating women's access to formal and informal professional networks, acknowledging and addressing the gender pay gap as well as the lack of research funding awarded to women in the field, and updating workplace policies that have not evolved to accommodate women's lifestyles. As academic institutions seek access to top talent and the means to develop those individuals capable of generating the change medicine and science needs, the authors urge leaders and change agents within academic medicine to address the systemic barriers to gender equity that impede us from achieving the mission to improve the health of all.

Nutrition in Patients with Gastric Cancer: An Update.

PubMed

Rosania, Rosa; Chiapponi, Costanza; Malfertheiner, Peter; Venerito, Marino

2016-05-01

Nutritional management of patients with gastric cancer (GC) represents a challenge. This review provides an overview of the present evidence on nutritional support in patients with GC undergoing surgery as well as in those with advanced disease. For patients undergoing surgery, the preoperative nutritional condition directly affects postoperative prognosis, overall survival and disease-specific survival. Perioperative nutritional support enriched with immune-stimulating nutrients reduces overall complications and hospital stay but not mortality after major elective gastrointestinal surgery. Early enteral nutrition after surgery improves early and long-term postoperative nutritional status and reduces the length of hospitalization as well. Vitamin B12 and iron deficiency are common metabolic sequelae after gastrectomy and warrant appropriate replacement. In malnourished patients with advanced GC, short-term home complementary parenteral nutrition improves the quality of life, nutritional status and functional status. Total home parenteral nutrition represents the only modality of caloric intake for patients with advanced GC who are unable to take oral or enteral nutrition. Early evaluations of nutritional status and nutritional support represent key aspects in the management of GC patients with both operable and advanced disease.

Implementation of a dynamic data entry system for the PHENIX gas system

NASA Astrophysics Data System (ADS)

Hagiwara, Masako

2003-10-01

The PHENIX detector at the BNL RHIC facility uses multiple detector technologies that require a precise gas delivery system, including flammable gases that require additional monitoring. During operation of the detector, it is crucial to maintain stable and safe operating conditions by carefully monitoring flows, pressures, and various other gas properties. These systems are monitored during running periods on a continuous basis. For the most part, these records were kept by hand, filling out a paper logsheet every four hours. A dynamic data entry system was needed to replace the paper logsheets. The solution created was to use a PDA or laptop computer with a wireless connection to enter the data directly into a MySQL database. The system uses PHP to dynamically create and update the data entry pages. The data entered can be viewed in graphs as well as tables. As a result, the data recorded will be easily accessible during PHENIX's next running period. It also allows for long term archiving, making the data available during the analysis phase, providing knowledge of the operating conditions of the gas system.

[Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): neurocritical patient].

PubMed

Acosta Escribano, J; Herrero Meseguer, I; Conejero García-Quijada, R

2011-11-01

Neurocritical patients require specialized nutritional support due to their intense catabolism and prolonged fasting. The preferred route of nutrient administration is the gastrointestinal route, especially the gastric route. Alternatives are the transpyloric route or mixed enteral-parenteral nutrition if an effective nutritional volume of more than 60% cannot be obtained. Total calore intake ranges from 20-30 kcal/kg/day, depending on the period of the clinical course, with protein intake higher than 20% of total calories (hyperproteic diet). Nutritional support should be initiated early. The incidence of gastrointestinal complications is generally higher to other critically-ill patients, the most frequent complication being an increase in gastric residual volume. As in other critically-ill patients, glycemia should be closely monitored and maintained below 150 mg/dL. Copyright © 2011 Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias (SEMICYUC) and Elsevier España, S.L. All rights reserved.

An Efficient Power Saving Technique Based Location Alarm For Smart Phones

NASA Astrophysics Data System (ADS)

Saranya, G.; Lavanya, S.; Sivasankari, S.

2018-04-01

In today’s world it is not possible for everything to work at the scheduled time. Therefore it is necessary that our daily applications remind us on a particular location instead of a particular time. When the reminder is set, it continuously checks the distance from the destination. If it matches with the maximum distance entered it reminds the user that he/she is about to reach their destination. When the user enters the proximity radius that was set in the application, the user is notified. The application is set to work with availability of GPS as well as mobile network data in the users’ device which runs on android platform. The application also limits the impact of battery life of its device by bringing down the rate of updates and background services when the device battery is low and hence optimizing the battery usage for further important tasks. The location can be either a place or the GPS location of other user. The notification can be enabled on both the users and both the user can be notified based on the proximity radius set by them.

Maintenance of Gastrointestinal Glucose Homeostasis by the Gut-Brain Axis.

PubMed

Chen, Xiyue; Eslamfam, Shabnam; Fang, Luoyun; Qiao, Shiyan; Ma, Xi

2017-01-01

Gastrointestinal homeostasis is a dynamic balance under the interaction between the host, GI tract, nutrition and energy metabolism. Glucose is the main energy source in living cells. Thus, glucose metabolic disorders can impair normal cellular function and endanger organisms' health. Diseases that are associated with glucose metabolic disorders such as obesity, diabetes, hypertension, and other metabolic syndromes are in fact life threatening. Digestive system is responsible for food digestion and nutrient absorption. It is also involved in neuronal, immune, and endocrine pathways. In addition, the gut microbiota plays an essential role in initiating signal transduction, and communication between the enteric and central nervous system. Gut-brain axis is composed of enteric neural system, central neural system, and all the efferent and afferent neurons that are involved in signal transduction between the brain and gut-brain. Gut-brain axis is influenced by the gut-microbiota as well as numerous neurotransmitters. Properly regulated gut-brain axis ensures normal digestion, absorption, energy production, and subsequently maintenance of glucose homeostasis. Understanding the underlying regulatory mechanisms of gut-brain axis involved in gluose homeostasis would enable us develop more efficient means of prevention and management of metabolic disease such as diabetic, obesity, and hypertension. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Armored Scales and Their Parasitoids on Commercial Avocados Grown in California or Imported from Mexico.

PubMed

Morse, J G; Rugman-Jones, P F; Woolley, J B; Heraty, J M; Triapitsyn, S V; Hofshi, R; Stouthamer, R

2016-10-01

Levels of armored scales (Hemiptera: Diaspididae) on Mexican Hass avocados imported into California over May 2008-June 2009 were monitored on 135 trucks entering the state via the Blythe border station, the entry point receiving the highest volume of fruit. Levels of live sessile scales were 3.9-fold higher than indicated in a previous survey (September 2007-April 2008) although levels of live eggs and crawlers were similar to previous levels. A survey of avocado fruit in California infested with armored scales detected four species known to be endemic but failed to find any of the seven exotic Diaspididae entering the state on Mexican fruit. Monitoring of Mexican armored scales on imported avocados from September 2007 to December 2010 recovered 10 species of parasitoids predominated by two species of Signiphora Ashmead (Hymenoptera: Signiphoridae). One of these species, Signiphora flavopalliata Ashmead, comprised 36% of all collected Mexican parasitoids and is a known hyperparasitoid. A survey of armored scale parasitoids present on commercial California avocados detected 17 genetic signatures, with only four of these in common with those detected on imported Mexican fruit. The implications of these findings are discussed. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Long-Term Placement Trajectories of Children Who Were Maltreated and Entered the Child Welfare System at an Early Age: Consequences for Physical and Behavioral Well-Being.

PubMed

Villodas, Miguel T; Litrownik, Alan J; Newton, Rae R; Davis, Inger P

2016-01-01

This study aimed to identify children's long-term placement trajectories following early child welfare involvement and the association of these trajectories with subsequent physical and behavioral well-being. Participants were 330 children who entered out-of-home care following a substantiated report of child abuse or neglect during infancy/early childhood and their caregivers. Participants were interviewed at child ages 4 and 12 years to assess children's physical and behavioral well-being and every 2 years in between to determine child placements. Latent Class Analyses identified four stable placement trajectories (i.e., adopted [32%], kinship care [15%], stable reunified [27%], and stable foster care [9%]), and two unstable trajectories (i.e., disrupted reunified [12%] and unstable foster care [5%]). Logistic regressions revealed that children in the unstable trajectories had significantly poorer physical and behavioral well-being than children in stable trajectories. Maltreated children placed in out-of-home care are at risk for long-term placement instability and poorer physical and behavioral well-being. © The Author 2015. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Flower opening and closure: an update.

PubMed

van Doorn, Wouter G; Kamdee, Chanattika

2014-11-01

This review is an update of a 2003 review (Journal of Experimental Botany 54,1801-1812) by the same corresponding author. Many examples of flower opening have been recorded using time-lapse photography, showing its velocity and the required elongation growth. Ethylene regulates flower opening, together with at least gibberellins and auxin. Ethylene and gibberellic acid often promote and inhibit, respectively, the expression of DELLA genes and the stability of DELLA proteins. DELLA results in growth inhibition. Both hormones also inhibited and promoted, respectively, the expression of aquaporin genes required for cell elongation. Arabidopsis miRNA319a mutants exhibited narrow and short petals, whereby miRNA319a indirectly regulates auxin effects. Flower opening in roses was controlled by a NAC transcription factor, acting through miRNA164. The regulatory role of light and temperature, in interaction with the circadian clock, has been further elucidated. The end of the life span in many flowers is determined by floral closure. In some species pollination resulted in earlier closure of turgid flowers, compared with unpollinated flowers. It is hypothesized that this pollination-induced effect is only found in flowers in which closure is regulated by ethylene. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PDB-wide collection of binding data: current status of the PDBbind database.

PubMed

Liu, Zhihai; Li, Yan; Han, Li; Li, Jie; Liu, Jie; Zhao, Zhixiong; Nie, Wei; Liu, Yuchen; Wang, Renxiao

2015-02-01

Molecular recognition between biological macromolecules and organic small molecules plays an important role in various life processes. Both structural information and binding data of biomolecular complexes are indispensable for depicting the underlying mechanism in such an event. The PDBbind database was created to collect experimentally measured binding data for the biomolecular complexes throughout the Protein Data Bank (PDB). It thus provides the linkage between structural information and energetic properties of biomolecular complexes, which is especially desirable for computational studies or statistical analyses. Since its first public release in 2004, the PDBbind database has been updated on an annual basis. The latest release (version 2013) provides experimental binding affinity data for 10,776 biomolecular complexes in PDB, including 8302 protein-ligand complexes and 2474 other types of complexes. In this article, we will describe the current methods used for compiling PDBbind and the updated status of this database. We will also review some typical applications of PDBbind published in the scientific literature. All contents of this database are freely accessible at the PDBbind-CN Web server at http://www.pdbbind-cn.org/. wangrx@mail.sioc.ac.cn. Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Design and evaluation of a personal digital assistant- based alerting service for clinicians.

PubMed

Johnson, E Diane; Pancoast, Paul E; Mitchell, Joyce A; Shyu, Chi-Ren

2004-10-01

This study describes the system architecture and user acceptance of a suite of programs that deliver information about newly updated library resources to clinicians' personal digital assistants (PDAs). Participants received headlines delivered to their PDAs alerting them to new books, National Guideline Clearinghouse guidelines, Cochrane Reviews, and National Institutes of Health (NIH) Clinical Alerts, as well as updated content in UpToDate, Harrison's Online, Scientific American Medicine, and Clinical Evidence. Participants could request additional information for any of the headlines, and the information was delivered via e-mail during their next synchronization. Participants completed a survey at the conclusion of the study to gauge their opinions about the service. Of the 816 headlines delivered to the 16 study participants' PDAs during the project, Scientific American Medicine generated the highest proportion of headline requests at 35%. Most users of the PDA Alerts software reported that they learned about new medical developments sooner than they otherwise would have, and half reported that they learned about developments that they would not have heard about at all. While some users liked the PDA platform for receiving headlines, it seemed that a Web database that allowed tailored searches and alerts could be configured to satisfy both PDA-oriented and e-mail-oriented users.

Advanced Strategic and Tactical Relay Request Management for the Mars Relay Operations Service

NASA Technical Reports Server (NTRS)

Allard, Daniel A.; Wallick, Michael N.; Gladden, Roy E.; Wang, Paul; Hy, Franklin H.

2013-01-01

This software provides a new set of capabilities for the Mars Relay Operations Service (MaROS) in support of Strategic and Tactical relay, including a highly interactive relay request Web user interface, mission control over relay planning time periods, and mission management of allowed strategic vs. tactical request parameters. Together, these new capabilities expand the scope of the system to include all elements critical for Tactical relay operations. Planning of replay activities spans a time period that is split into two distinct phases. The first phase is called Strategic, which begins at the time that relay opportunities are identified, and concludes at the point that the orbiter generates the flight sequences for on board execution. Any relay request changes from this point on are called Tactical. Tactical requests, otherwise called Orbit - er Relay State Changes (ORSC), are highly restricted in terms of what types of changes can be made, and the types of parameters that can be changed may differ from one orbiter to the next. For example, one orbiter may be able to delay the start of a relay request, while another may not. The legacy approach to ORSC management involves exchanges of e-mail with "requests for change" and "acknowledgement of approval," with no other tracking of changes outside of e-mail folders. MaROS Phases 1 and 2 provided the infrastructure for strategic relay for all supported missions. This new version, 3.0, introduces several capabilities that fully expand the scope of the system to include tactical relay. One new feature allows orbiter users to manage and "lock" Planning Periods, which allows the orbiter team to formalize the changeover from Strategic to Tactical operations. Another major feature allows users to interactively submit tactical request changes via a Web user interface. A third new feature allows orbiter missions to specify allowed tactical updates, which are automatically incorporated into the tactical change process. This software update is significant in that it provides the only centralized service for tactical request management available for relay missions.

Supporting student nurses in practice with additional online communication tools.

PubMed

Morley, Dawn A

2014-01-01

Student nurses' potential isolation and difficulties of learning on placement have been well documented and, despite attempts to make placement learning more effective, evidence indicates the continuing schism between formal learning at university and situated learning on placement. First year student nurses, entering placement for the first time, are particularly vulnerable to the vagaries of practice. During 2012 two first year student nurse seminar groups (52 students) were voluntarily recruited for a mixed method study to determine the usage of additional online communication support mechanisms (Facebook, wiki, an email group and traditional methods of support using individual email or phone) while undertaking their first five week clinical placement. The study explores the possibility of strengthening clinical learning and support by promoting the use of Web 2.0 support groups for student nurses. Results indicate a high level of interactivity in both peer and academic support in the use of Facebook and a high level of interactivity in one wiki group. Students' qualitative comments voice an appreciation of being able to access university and peer support whilst working individually on placement. Recommendations from the study challenge universities to use online communication tools already familiar to students to complement the support mechanisms that exist for practice learning. This is tempered by recognition of the responsibility of academics to ensure their students are aware of safe and effective online communication. Copyright © 2013 Elsevier Ltd. All rights reserved.

Travel-acquired infections in Canada: CanTravNet 2011—2012

PubMed Central

Boggild, AK; Geduld, J; Libman, M; Ward, BJ; McCarthy, A; Hajek, J; Ghesquiere, W; Vincelette, J; Kuhn, S; Freedman, DO; Kain, KC

2014-01-01

Background Important gaps remain in our knowledge of the infectious diseases people acquire while travelling and the impact of pathogens imported by Canadian travellers. Objective To provide a surveillance update of illness in a cohort of returned Canadian travellers and new immigrants. Methods Data on returning Canadian travellers and new immigrants presenting to a CanTravNet site between September 2011 and September 2012 were extracted and analyzed by destination, presenting symptoms, common and emerging infectious diseases and disease severity. Results During the study period, 2283 travellers and immigrants presented to a CanTravNet site, 88% (N=2004) of whom were assigned a travel-related diagnosis. Top three destinations for non-immigrant travellers were India (N=132), Mexico (N=103) and Cuba (N=89). Fifty-one cases of malaria were imported by ill returned travellers during the study period, 60% (N=30) of which were Plasmodium falciparum infections. Individuals travelling to visit friends and relatives accounted for 83% of enteric fever cases (15/18) and 41% of malaria cases (21/51). The requirement for inpatient management was over-represented among those with malaria compared to those without malaria (25% versus 2.8%; p<0.0001) and those travelling to visit friends and relatives versus those travelling for other reasons (12.1% versus 2.4%; p<0.0001). Nine new cases of HIV were diagnosed among the cohort, as well as one case of acute hepatitis B. Emerging infections among travellers included hepatitis E virus (N=6), chikungunya fever (N=4) and cutaneous leishmaniasis (N=16). Common chief complaints included gastrointestinal (N=804), dermatologic (N=440) and fever (N=287). Common specific causes of chief complaint of fever in the cohort were malaria (N=47/51 total cases), dengue fever (14/18 total cases), enteric fever (14/17 total cases) and influenza and influenza-like illness (15/21 total cases). Animal bites were the tenth most common diagnosis among tourist travellers. Interpretation Our analysis of surveillance data on ill returned Canadian travellers provides a recent update to the spectrum of imported illness among travelling Canadians. Preventable travel-acquired illnesses and injuries in the cohort include malaria, enteric fever, HIV, hepatitis B, hepatitis A, influenza and animal bites. Strategies to improve uptake of preventive interventions such as malaria chemoprophylaxis, immunizations and arthropod/animal avoidance may be warranted. PMID:29769859

Development of cell-penetrating bispecific antibodies targeting the N-terminal domain of androgen receptor for prostate cancer therapy.

PubMed

Goicochea, Nancy L; Garnovskaya, Maria; Blanton, Mary G; Chan, Grace; Weisbart, Richard; Lilly, Michael B

2017-12-01

Castration-resistant prostate cancer cells exhibit continued androgen receptor signaling in spite of low levels of ligand. Current therapies to block androgen receptor signaling act by inhibiting ligand production or binding. We developed bispecific antibodies capable of penetrating cells and binding androgen receptor outside of the ligand-binding domain. Half of the bispecific antibody molecule consists of a single-chain variable fragment of 3E10, an anti-DNA antibody that enters cells. The other half is a single-chain variable fragment version of AR441, an anti-AR antibody. The resulting 3E10-AR441 bispecific antibody enters human LNCaP prostate cells and accumulates in the nucleus. The antibody binds to wild-type, mutant and splice variant androgen receptor. Binding affinity of 3E10-AR441 to androgen receptor (284 nM) was lower than that of the parental AR441 mAb (4.6 nM), but could be improved (45 nM) through alternative placement of the affinity tags, and ordering of the VH and VK domains. The 3E10-AR441 bispecific antibody blocked genomic signaling by wild-type or splice variant androgen receptor in LNCaP cells. It also blocked non-genomic signaling by the wild-type receptor. Furthermore, bispecific antibody inhibited the growth of C4-2 prostate cancer cells under androgen-stimulated conditions. The 3E10-AR441 biAb can enter prostate cancer cells and inhibits androgen receptor function in a ligand-independent manner. It may be an attractive prototype agent for prostate cancer therapy. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Probiotics for prevention of necrotizing enterocolitis in preterm infants.

PubMed

AlFaleh, Khalid; Anabrees, Jasim

2014-09-01

Necrotizing enterocolitis (NEC) and nosocomial sepsis are associated with increased morbidity and mortality in preterm infants. Through prevention of bacterial migration across the mucosa, competitive exclusion of pathogenic bacteria, and enhancing the immune responses of the host, prophylactic enteral probiotics (live microbial supplements) may play a role in reducing NEC and the associated morbidity. To compare the efficacy and safety of prophylactic enteral probiotics administration versus placebo or no treatment in the prevention of severe NEC or sepsis, or both, in preterm infants. For this update, searches were made of MEDLINE (1966 to October 2013), EMBASE (1980 to October 2013), the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2013, Issue 10), and abstracts of annual meetings of the Society for Pediatric Research (1995 to 2013). Only randomized or quasi-randomized controlled trials that enrolled preterm infants < 37 weeks gestational age or < 2500 g birth weight, or both, were considered. Trials were included if they involved enteral administration of any live microbial supplement (probiotics) and measured at least one prespecified clinical outcome. Standard methods of The Cochrane Collaboration and its Neonatal Group were used to assess the methodologic quality of the trials and for data collection and analysis. Twenty-four eligible trials were included. Included trials were highly variable with regard to enrolment criteria (that is birth weight and gestational age), baseline risk of NEC in the control groups, timing, dose, formulation of the probiotics, and feeding regimens. In a meta-analysis of trial data, enteral probiotics supplementation significantly reduced the incidence of severe NEC (stage II or more) (typical relative risk (RR) 0.43, 95% confidence interval (CI) 0.33 to 0.56; 20 studies, 5529 infants) and mortality (typical RR 0.65, 95% CI 0.52 to 0.81; 17 studies, 5112 infants). There was no evidence of significant reduction of nosocomial sepsis (typical RR 0.91, 95% CI 0.80 to 1.03; 19 studies, 5338 infants). The included trials reported no systemic infection with the supplemental probiotics organism. Probiotics preparations containing either lactobacillus alone or in combination with bifidobacterium were found to be effective. Enteral supplementation of probiotics prevents severe NEC and all cause mortality in preterm infants. Our updated review of available evidence strongly supports a change in practice. Head to head comparative studies are required to assess the most effective preparations, timing, and length of therapy to be utilized. Probiotics for prevention of necrotizing enterocolitis in preterm infants Necrotizing enterocolitis (NEC) is a serious disease that affects the bowel of premature infants in the first few weeks of life. Although the cause of NEC is not entirely known, milk feeding and bacterial growth play a role. Probiotics (dietary supplements containing potentially beneficial bacteria or yeast) have been used to prevent NEC. Our review of studies found that the use of probiotics reduces the occurrence of NEC and death in premature infants born weighing less than 1500 grams. There is insufficient data with regard to the benefits and potential adverse effects in the most at risk infants weighing less than 1000 grams at birth. Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Data from Theodolite Measurements of Creep Rates on San Francisco Bay Region Faults, California: 1979-2007

USGS Publications Warehouse

McFarland, Forrest S.; Lienkaemper, James J.; Caskey, S. John; Grove, Karen

2007-01-01

Introduction Our purpose is to update with six additional years of data, our creep data archive on San Francisco Bay region active faults for use by the scientific research community. Earlier data (1979-2001) were reported in Galehouse (2002) and were analyzed and described in detail in a summary report (Galehouse and Lienkaemper, 2003). A complete analysis of our earlier results obtained on the Hayward fault was presented in Lienkaemper, Galehouse and Simpson (2001). Jon Galehouse of San Francisco State University (SFSU) and many student research assistants measured creep (aseismic slip) rates on these faults from 1979 until his retirement from the project in 2001. The creep measurement project, which was initiated by Galehouse, has continued through the Geosciences Department at SFSU from 2001-2006 under the direction of Co-P.I.'s Karen Grove and John Caskey (Grove and Caskey, 2005), and by Caskey since 2006. Forrest McFarland has managed most of the technical and logistical project operations as well as data processing and compilation since 2001. We plan to publish detailed analyses of these updated creep data in future publications. We maintain a project web site (http://funnel.sfsu.edu/creep/) that includes the following information: project description, project personnel, creep characteristics and measurement, map of creep measurement sites, creep measurement site information, and data plots for each measurement site. Our most current, annually updated results are therefore accessible to the scientific community and to the general public. Information about the project can currently be requested by the public by an email link (fltcreep@sfsu.edu) found on our project website.

Updating the Evidence for Physical Activity: Summative Reviews of the Epidemiological Evidence, Prevalence, and Interventions to Promote "Active Aging".

PubMed

Bauman, Adrian; Merom, Dafna; Bull, Fiona C; Buchner, David M; Fiatarone Singh, Maria A

2016-04-01

There is a global imperative to increase awareness of the emerging evidence on physical activity (PA) among older adults. "Healthy aging" has traditionally focused on preventing chronic disease, but greater efforts are required to reduce frailty and dependency and to maintain independent physical and cognitive function and mental health and well-being. This integrated review updates the epidemiological data on PA, summarizes the existing evidence-based PA guidelines, describes the global magnitude of inactivity, and finally describes the rationale for action. The first section updates the epidemiological evidence for reduced cardiometabolic risk, reduced risks of falls, the burgeoning new evidence on improved cognitive function and functional capacity, and reduced risk of depression, anxiety, and dementia. This is followed by a summary of population prevalence studies among older adults. Finally, we present a "review of reviews" of PA interventions delivered from community or population settings, followed by a consideration of interventions among the "oldest-old," where efforts are needed to increase resistance (strength) training and balance. This review identifies the global importance of considering "active aging" beyond the established benefits attributed to noncommunicable disease prevention alone. Innovative population-level efforts are required to address physical inactivity, prevent loss of muscle strength, and maintain balance in older adults. Specific investment in healthy aging requires global policy support from the World Health Organization and is implemented at the national and regional levels, in order to reduce the burden of disease and disability among older adults. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Update on Foregut Molecular Embryology and Role of Regenerative Medicine Therapies

PubMed Central

Perin, Silvia; McCann, Conor J.; Borrelli, Osvaldo; De Coppi, Paolo; Thapar, Nikhil

2017-01-01

Esophageal atresia (OA) represents one of the commonest and most severe developmental disorders of the foregut, the most proximal segment of the gastrointestinal (GI) tract (esophagus and stomach) in embryological terms. Of intrigue is the common origin from this foregut of two very diverse functional entities, the digestive and respiratory systems. OA appears to result from incomplete separation of the ventral and dorsal parts of the foregut during development, resulting in disruption of esophageal anatomy and frequent association with tracheo-oesophageal fistula. Not surprisingly, and likely inherent to OA, are associated abnormalities in components of the enteric neuromusculature and ultimately loss of esophageal functional integrity. An appreciation of such developmental processes and associated defects has not only enhanced our understanding of the etiopathogenesis underlying such devastating defects but also highlighted the potential of novel corrective therapies. There has been considerable progress in the identification and propagation of neural crest stem cells from the GI tract itself or derived from pluripotent cells. Such cells have been successfully transplanted into models of enteric neuropathy confirming their ability to functionally integrate and replenish missing or defective enteric nerves. Combinatorial approaches in tissue engineering hold significant promise for the generation of organ-specific scaffolds such as the esophagus with current initiatives directed toward their cellularization to facilitate optimal function. This chapter outlines the most current understanding of the molecular embryology underlying foregut development and OA, and also explores the promise of regenerative medicine. PMID:28503544

Update on Foregut Molecular Embryology and Role of Regenerative Medicine Therapies.

PubMed

Perin, Silvia; McCann, Conor J; Borrelli, Osvaldo; De Coppi, Paolo; Thapar, Nikhil

2017-01-01

Esophageal atresia (OA) represents one of the commonest and most severe developmental disorders of the foregut, the most proximal segment of the gastrointestinal (GI) tract (esophagus and stomach) in embryological terms. Of intrigue is the common origin from this foregut of two very diverse functional entities, the digestive and respiratory systems. OA appears to result from incomplete separation of the ventral and dorsal parts of the foregut during development, resulting in disruption of esophageal anatomy and frequent association with tracheo-oesophageal fistula. Not surprisingly, and likely inherent to OA, are associated abnormalities in components of the enteric neuromusculature and ultimately loss of esophageal functional integrity. An appreciation of such developmental processes and associated defects has not only enhanced our understanding of the etiopathogenesis underlying such devastating defects but also highlighted the potential of novel corrective therapies. There has been considerable progress in the identification and propagation of neural crest stem cells from the GI tract itself or derived from pluripotent cells. Such cells have been successfully transplanted into models of enteric neuropathy confirming their ability to functionally integrate and replenish missing or defective enteric nerves. Combinatorial approaches in tissue engineering hold significant promise for the generation of organ-specific scaffolds such as the esophagus with current initiatives directed toward their cellularization to facilitate optimal function. This chapter outlines the most current understanding of the molecular embryology underlying foregut development and OA, and also explores the promise of regenerative medicine.

Duck virus enteritis (duck plague) - a comprehensive update.

PubMed

Dhama, Kuldeep; Kumar, Naveen; Saminathan, Mani; Tiwari, Ruchi; Karthik, Kumaragurubaran; Kumar, M Asok; Palanivelu, M; Shabbir, Muhammad Zubair; Malik, Yashpal Singh; Singh, Raj Kumar

2017-12-01

Duck virus enteritis (DVE), also called duck plague, is one of the major contagious and fatal diseases of ducks, geese and swan. It is caused by duck enteritis virus (DEV)/Anatid herpesvirus-1 of the genus Mardivirus, family Herpesviridae, and subfamily Alpha-herpesvirinae. Of note, DVE has worldwide distribution, wherein migratory waterfowl plays a crucial role in its transmission within and between continents. Furthermore, horizontal and/ or vertical transmission plays a significant role in disease spread through oral-fecal discharges. Either of sexes from varying age groups of ducks is vulnerable to DVE. The disease is characterized by sudden death, vascular damage and subsequent internal hemorrhage, lesions in lymphoid organs, digestive mucosal eruptions, severe diarrhea and degenerative lesions in parenchymatous organs. Huge economic losses are connected with acute nature of the disease, increased morbidity and mortality (5%-100%), condemnations of carcasses, decreased egg production and hatchability. Although clinical manifestations and histopathology can provide preliminary diagnosis, the confirmatory diagnosis involves virus isolation and detection using serological and molecular tests. For prophylaxis, both live-attenuated and killed vaccines are being used in broiler and breeder ducks above 2 weeks of age. Since DEV is capable of becoming latent as well as shed intermittently, recombinant subunit and DNA vaccines either alone or in combination (polyvalent) are being targeted for its benign prevention. This review describes DEV, epidemiology, transmission, the disease (DVE), pathogenesis, and advances in diagnosis, vaccination and antiviral agents/therapies along with appropriate prevention and control strategies.

Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group.

PubMed

Calder, Philip C; Adolph, Michael; Deutz, Nicolaas E; Grau, Teodoro; Innes, Jacqueline K; Klek, Stanislaw; Lev, Shaul; Mayer, Konstantin; Michael-Titus, Adina T; Pradelli, Lorenzo; Puder, Mark; Vlaardingerbroek, Hester; Singer, Pierre

2018-02-01

This article summarizes the presentations given at an ESPEN Workshop on "Lipids in the ICU" held in Tel Aviv, Israel in November 2014 and subsequent discussions and updates. Lipids are an important component of enteral and parenteral nutrition support and provide essential fatty acids, a concentrated source of calories and building blocks for cell membranes. Whilst linoleic acid-rich vegetable oil-based enteral and parenteral nutrition is still widely used, newer lipid components such as medium-chain triglycerides and olive oil are safe and well tolerated. Fish oil (FO)-enriched enteral and parenteral nutrition appears to be well tolerated and confers additional clinical benefits, particularly in surgical patients, due to its anti-inflammatory and immune-modulating effects. Whilst the evidence base is not conclusive, there appears to be a potential for FO-enriched nutrition, particularly administered peri-operatively, to reduce the rate of complications and intensive care unit (ICU) and hospital stay in surgical ICU patients. The evidence for FO-enriched nutrition in non-surgical ICU patients is less clear regarding its clinical benefits and additional, well-designed large-scale clinical trials need to be conducted in this area. The ESPEN Expert Group supports the use of olive oil and FO in nutrition support in surgical and non-surgical ICU patients but considers that further research is required to provide a more robust evidence base. Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Vision of a cyberinfrastructure for nonnative, invasive species management

USGS Publications Warehouse

2008-01-01

Although the quantity of data on the location, status, and management of invasive species is ever increasing, invasive species data sets are often difficult to obtain and integrate. A cyberinfrastructure for such information could make these data available for Internet users. The data can be used to create regional watch lists, to send e-mail alerts when a new species enters a region, to construct models of species' current and future distributions, and to inform management. Although the exchange of environmental data over the Internet in the form of raster data is maturing, and the exchange of species occurrence data is developing quickly, there is room for improvement. In this article, we present a vision for a comprehensive invasive species cyberinfrastructure that is capable of accessing data effectively, creating models of invasive species spread, and distributing this information.

Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear Memories

PubMed Central

Jarome, Timothy J; Ferrara, Nicole C; Kwapis, Janine L; Helmstetter, Fred J

2015-01-01

Stored memories enter a temporary state of vulnerability following retrieval known as ‘reconsolidation', a process that can allow memories to be modified to incorporate new information. Although reconsolidation has become an attractive target for treatment of memories related to traumatic past experiences, we still do not know what new information triggers the updating of retrieved memories. Here, we used biochemical markers of synaptic plasticity in combination with a novel behavioral procedure to determine what was learned during memory reconsolidation under normal retrieval conditions. We eliminated new information during retrieval by manipulating animals' training experience and measured changes in proteasome activity and GluR2 expression in the amygdala, two established markers of fear memory lability and reconsolidation. We found that eliminating new contextual information during the retrieval of memories for predictable and unpredictable fear associations prevented changes in proteasome activity and glutamate receptor expression in the amygdala, indicating that this new information drives the reconsolidation of both predictable and unpredictable fear associations on retrieval. Consistent with this, eliminating new contextual information prior to retrieval prevented the memory-impairing effects of protein synthesis inhibitors following retrieval. These results indicate that under normal conditions, reconsolidation updates memories by incorporating new contextual information into the memory trace. Collectively, these results suggest that controlling contextual information present during retrieval may be a useful strategy for improving reconsolidation-based treatments of traumatic memories associated with anxiety disorders such as post-traumatic stress disorder. PMID:26062788

Probing Gallic Acid for Its Broad Spectrum Applications.

PubMed

Choubey, Sneha; Goyal, Soniya; Varughese, Lesley Rachel; Kumar, Vinod

2018-03-29

Gallic acid and its derivatives not only exhibit excellent antioxidant, anticarcinogenic, antimutagenic, antimicrobial properties but also provide protection to the cells against oxidative stress. Gallic acid (3, 4, 5-trihydroxybenzoic acid), a low molecular triphenolic compound has arised as an efficient apoptosis inducing agent. The antimicrobial and other biological properties of gallic acid and its derivatives seemed to be linked with the hydrolysis of ester linkage between gallic acid and polyols like tannins hydrolyzed after ripening of many edible fruits. Gallic acid serves a natural defense mechanism against microbial infections and modulation of immune-responses. The current review updates us with the diverse roles played by gallic acid, its antioxidant potential, action mechanism and more importantly the diverse array of applications in therapeutic and pharmaceutical area. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Supporting REU Leaders and Effective Workforce Development in the Geosciences

NASA Astrophysics Data System (ADS)

Sloan, V.; Haacker, R.

2014-12-01

Research shows that research science experiences for undergraduates are key to the engagement of students in science, and teach critical thinking and communication, as well as the professional development skills. Nonetheless, undergraduate research programs are time and resource intensive, and program managers work in relative isolation from each other. The benefits of developing an REU community include sharing strategies and policies, developing collaborative efforts, and providing support to each other. This paper will provide an update on efforts to further develop the Geoscience REU network, including running a national workshop, an email listserv, workshops, and the creation of online resources for REU leaders. The goal is to strengthen the connections between REU community members, support the sharing of best practices in a changing REU landscape, and to make progress in formalizing tools for REU site managers.

Closed-Cycle Hydrogen-Oxygen Regenerative Fuel Cell at the NASA Glenn Research Center-An Update

NASA Technical Reports Server (NTRS)

Bents, David J.; Chang, Bei-Jiann; Johnson, Donald W.; Garcia, Christopher P.

2008-01-01

The closed cycle hydrogen-oxygen proton exchange membrane (PEM) regenerative fuel cell (RFC) at the NASA Glenn Research Center has demonstrated multiple back-to-back contiguous cycles at rated power and round-trip efficiencies up to 52 percent. It is the first fully closed cycle RFC ever demonstrated. (The entire system is sealed; nothing enters or escapes the system other than electrical power and heat.) During fiscal year fiscal year (FY) FY06 to FY07, the system s numerous modifications and internal improvements focused on reducing parasitic power, heat loss, and noise signature; increasing its functionality as an unattended automated energy storage device; and in-service reliability.

Reactor shutdown experience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cletcher, J.W.

1995-10-01

This is a regular report of summary statistics relating to recent reactor shutdown experience. The information includes both number of events and rates of occurence. It was compiled from data about operating events that were entered into the SCSS data system by the Nuclear Operations Analysis Center at the Oak ridge National Laboratory and covers the six mont period of July 1 to December 31, 1994. Cumulative information, starting from May 1, 1994, is also reported. Updates on shutdown events included in earlier reports is excluded. Information on shutdowns as a function of reactor power at the time of themore » shutdown for both BWR and PWR reactors is given. Data is also discerned by shutdown type and reactor age.« less

Minority University Research and Education Division (MURED) Update

NASA Technical Reports Server (NTRS)

Malone, John

2000-01-01

Program priorities include: (1) Expand and advance NASA's scientific and technological base by building on prior year's efforts in research and academic infrastructure; (2) Increase exposure to NASA's unique mission and facilities by developing closer relationships with NASA Strategic Enterprises; (3) Increase involvement in competitive peer review and merit selection processes; (4) Contribute significantly to the Agency's strategic goals and objectives; (5) Create systemic and sustainable change through partnerships and programs that enhance research and education programs; (6) Prepare faculty and students at HBCU's for NASA-related fields and increase number of students that enter and successfully complete degrees in NASA-related fields; (7) Establish measurable program goals and objectives; and (8) Improve financial management performance.

The Atacama Large Millimeter/submillimeter Array - from Early Science to Full Operations.

NASA Astrophysics Data System (ADS)

Remijan, Anthony

2017-06-01

The Atacama Large Millimeter/Submillimeter Array (ALMA) is now entering its 6th cycle of scientific observations. Starting with Cycle 3, science observations were no longer considered "Early Science" or "best efforts". Cycle 5 is now the third cycle of "steady state" observations and Cycle 7 is advertised to begin ALMA "full science" operations. ALMA Full Science Operations will include all the capabilities that were agreed upon by the international consortium after the ALMA re-baselining effort. In this talk, I will detail the upcoming ALMA Cycle 5 observing capabilities, describe the process of selecting new observing modes for upcoming cycles and provide an update on the status of the ALMA Full Science capabilities.

Hawaii bibliographic database

USGS Publications Warehouse

Wright, T.L.; Takahashi, T.J.

1998-01-01

The Hawaii bibliographic database has been created to contain all of the literature, from 1779 to the present, pertinent to the volcanological history of the Hawaiian-Emperor volcanic chain. References are entered in a PC- and Macintosh-compatible EndNote Plus bibliographic database with keywords and abstracts or (if no abstract) with annotations as to content. Keywords emphasize location, discipline, process, identification of new chemical data or age determinations, and type of publication. The database is updated approximately three times a year and is available to upload from an ftp site. The bibliography contained 8460 references at the time this paper was submitted for publication. Use of the database greatly enhances the power and completeness of library searches for anyone interested in Hawaiian volcanism.

Automated grading of homework assignments and tests in introductory and intermediate statistics courses using active server pages.

PubMed

Stockburger, D W

1999-05-01

Active server pages permit a software developer to customize the Web experience for users by inserting server-side script and database access into Web pages. This paper describes applications of these techniques and provides a primer on the use of these methods. Applications include a system that generates and grades individualized homework assignments and tests for statistics students. The student accesses the system as a Web page, prints out the assignment, does the assignment, and enters the answers on the Web page. The server, running on NT Server 4.0, grades the assignment, updates the grade book (on a database), and returns the answer key to the student.

Lunar Quest in Second Life, Lunar Exploration Island, Phase II

NASA Astrophysics Data System (ADS)

Ireton, F. M.; Day, B. H.; Mitchell, B.; Hsu, B. C.

2010-12-01

Linden Lab’s Second Life is a virtual 3D metaverse created by users. At any one time there may be 40,000-50,000 users on line. Users develop a persona and are seen on screen as a human figure or avatar. Avatars move through Second Life by walking, flying, or teleporting. Users form communities or groups of mutual interest such as music, computer graphics, and education. These groups communicate via e-mail, voice, and text within Second Life. Information on downloading the Second Life browser and joining can be found on the Second Life website: www.secondlife.com. This poster details Phase II in the development of Lunar Exploration Island (LEI) located in Second Life. Phase I LEI highlighted NASA’s LRO/LCROSS mission. Avatars enter LEI via teleportation arriving at a hall of flight housing interactive exhibits on the LRO/ LCROSS missions including full size models of the two spacecraft and launch vehicle. Storyboards with information about the missions interpret the exhibits while links to external websites provide further information on the mission, both spacecraft’s instrument suites, and related EPO. Other lunar related activities such as My Moon and NLSI EPO programs. A special exhibit was designed for International Observe the Moon Night activities with links to websites for further information. The sim includes several sites for meetings, a conference stage to host talks, and a screen for viewing NASATV coverage of mission and other televised events. In Phase II exhibits are updated to reflect on-going lunar exploration highlights, discoveries, and future missions. A new section of LEI has been developed to showcase NASA’s Lunar Quest program. A new exhibit hall with Lunar Quest information has been designed and is being populated with Lunar Quest information, spacecraft models (LADEE is in place) and kiosks. A two stage interactive demonstration illustrates lunar phases with static and 3-D stations. As NASA’s Lunar Quest program matures further exhibits are planned. One proposal is to develop a teacher-training program to acquaint teachers with the Lunar Quest program and to provide resources.

Planetary Nomenclature: An Overview and Update for 2017

NASA Astrophysics Data System (ADS)

Gaither, Tenielle; Hayward, Rose; IAU Working GroupPlanetary System Nomenclature

2017-10-01

The task of naming planetary surface features, rings, and natural satellites is managed by the International Astronomical Union’s (IAU) Working Group for Planetary System Nomenclature (WGPSN). There are currently 15,361 IAU-approved surface feature names on 41 planetary bodies, including moons and asteroids. The members of the WGPSN and its task groups have worked since the early 1970s to provide a clear, unambiguous system of planetary nomenclature that represents cultures and countries from all regions of Earth. WGPSN members include Rita Schulz (Chair) and 9 other members representing countries around the globe. The participation of knowledgeable scientists and experts in this process is vital to its success of the IAU WGPSN . Planetary nomenclature is a tool used to uniquely identify features on the surfaces of planets or satellites so they can be located, described, and discussed in publications, including peer-review journals, maps and conference presentations. Approved names are listed in the Transactions of the IAU and on the Gazetteer of Planetary Nomenclature website. Any names currently in use that are not listed the Gazetteer are not official. Planetary names must adhere to rules and conventions established by the IAU WGPSN (see http://planetarynames.wr.usgs.gov/Page/Rules for the complete list). The gazetteer includes an online Name Request Form (http://planetarynames.wr.usgs.gov/FeatureNameRequest) that can be used by members of the professional science community. Name requests are first reviewed by one of six task groups (Mercury, Venus, Moon, Mars, Outer Solar System, and Small Bodies). After a task group has reviewed a proposal, it is submitted to the WGPSN. Allow four to six weeks for the review and approval process. Upon WGPSN approval, names are considered formally approved and it is then appropriate to use them in publications. Approved names are immediately entered into the database and shown on the website. Questions about the nomenclature database and the naming process can be sent to Rosalyn Hayward, USGS Astrogeology Science Center, 2255 N. Gemini Dr., Flagstaff, AZ 86001, or by email to rhayward@usgs.gov.

The Use of Technology in Participant Tracking and Study Retention: Lessons Learned from a Clinical Trials Network Study

PubMed Central

Mitchell, Shannon Gwin; Schwartz, Robert P.; Alvanzo, Anika A. H.; Weisman, Monique S.; Kyle, Tiffany L.; Turrigiano, Eva M.; Gibson, Martha L.; Perez, Livangelie; McClure, Erin A.; Clingerman, Sara; Froias, Autumn; Shandera, Danielle R.; Walker, Robrina; Babcock, Dean L.; Bailey, Genie L.; Miele, Gloria M.; Kunkel, Lynn E.; Norton, Michael; Stitzer, Maxine L.

2015-01-01

Background The growing use of newer communication and internet technologies, even among low income and transient populations, require research staff to update their outreach strategies to ensure high follow-up and participant retention rates. This paper presents the views of research assistants on the use of cell phones and the internet to track participants in a multi-site randomized trial of substance use disorder treatment. Methods Pre-interview questionnaires exploring tracking and other study-related activities were collected from 21 research staff across the 10 participating US sites. Data were then used to construct a semi-structured interview guide which, in turn, was used to interview 12 of the same staff members. The questionnaires and interview data were entered in Atlas.ti and analyzed for emergent themes related to the use of technology for participant tracking purposes. Results Study staff reported that most participants had cell phones, despite having unstable physical addresses and landlines. The incoming call feature of most cell phones was useful for participants and research staff alike, and texting proved to have additional benefits. However, reliance on participants’ cell phones also proved problematic. Even homeless participants were found to have access to the internet through public libraries and could respond to study staff e-mails. Some study sites opened generic social media accounts, through which study staff sent private messages to participants. However, the Institutional Review Board (IRB) approval process for tracking participants using social media at some sites was prohibitively lengthy. Internet searches through Google, national paid databases, obituaries, and judiciary websites were also helpful tools. Conclusions Research staff perceive that cell phones, internet searches, and social networking sites were effective tools to achieve high follow-up rates in drug abuse research. Studies should incorporate cell phone, texting, and social network website information on locator forms; obtain IRB approval for contacting participants using social networking websites; and include web searches, texting, and the use of social media in staff training as standard operating procedures. PMID:25671593