Role of the Insect Supervectors Bemisia tabaci and Frankliniella occidentalis in the Emergence and Global Spread of Plant Viruses.

PubMed

Gilbertson, Robert L; Batuman, Ozgur; Webster, Craig G; Adkins, Scott

2015-11-01

Emergence of insect-transmitted plant viruses over the past 10-20 years has been disproportionately driven by two so-called supervectors: the whitefly, Bemisia tabaci, and the Western flower thrips, Frankliniella occidentalis. High rates of reproduction and dispersal, extreme polyphagy, and development of insecticide resistance, together with human activities, have made these insects global pests. These supervectors transmit a diversity of plant viruses by different mechanisms and mediate virus emergence through local evolution, host shifts, mixed infections, and global spread. Associated virus evolution involves reassortment, recombination, and component capture. Emergence of B. tabaci-transmitted geminiviruses (begomoviruses), ipomoviruses, and torradoviruses has led to global disease outbreaks as well as multiple paradigm shifts. Similarly, F. occidentalis has mediated tospovirus host shifts and global dissemination and the emergence of pollen-transmitted ilarviruses. The plant virus-supervector interaction offers exciting opportunities for basic research and global implementation of generalized disease management strategies to reduce economic and environmental impacts.

Special Issue "Biomaterials and Bioprinting".

PubMed

Chua, Chee Kai; Yeong, Wai Yee; An, Jia

2016-09-14

The emergence of bioprinting in recent years represents a marvellous advancement in 3D printing technology. It expands the range of 3D printable materials from the world of non-living materials into the world of living materials. Biomaterials play an important role in this paradigm shift. This Special Issue focuses on biomaterials and bioprinting and contains eight articles covering a number of recent topics in this emerging area.

Shifting Paradigms of Research in Medical Education.

ERIC Educational Resources Information Center

Irby, David M.; Edwards, Janine C. Ed.

1990-01-01

Medical educators debate which models of scientific research should be applied to problems in academic medicine. The reigning model was derived from the first scientific revolution of Newtonian physics. The emerging model is grounded in the second scientific revolution of Einstein's quantum physics. (Author/MSE)

Preoperative planning of thoracic surgery with use of three-dimensional reconstruction, rapid prototyping, simulation and virtual navigation

PubMed Central

Heuts, Samuel; Maessen, Jos G.

2016-01-01

For the past decades, surgeries have become more complex, due to the increasing age of the patient population referred for thoracic surgery, more complex pathology and the emergence of minimally invasive thoracic surgery. Together with the early detection of thoracic disease as a result of innovations in diagnostic possibilities and the paradigm shift to personalized medicine, preoperative planning is becoming an indispensable and crucial aspect of surgery. Several new techniques facilitating this paradigm shift have emerged. Pre-operative marking and staining of lesions are already a widely accepted method of preoperative planning in thoracic surgery. However, three-dimensional (3D) image reconstructions, virtual simulation and rapid prototyping (RP) are still in development phase. These new techniques are expected to become an important part of the standard work-up of patients undergoing thoracic surgery in the future. This review aims at graphically presenting and summarizing these new diagnostic and therapeutic tools PMID:29078505

Effects of holistic nursing course: a paradigm shift for holistic health practices.

PubMed

Downey, Marty

2007-06-01

A study of an undergraduate course in holistic nursing was conducted to determine its impact on personal and professional health care practices. A mixed method design was used to examine responses on a sample of 200 participants. Results indicated a positive personal impact with continued application of concepts into professional health practices. Personal and professional nursing practices were influenced from 1 to 7 years after completing the holistic nursing course. After introduction of the concepts of self-care and holistic approaches to health, students and graduates experienced a shift in values and beliefs related to their own health practices. Continued exposure to holistic practices creates a pattern of awareness toward health that affects future personal and professional nursing practice, creating a paradigm shift for emerging nursing students and graduates from the course. This affects the manner in which nurses meet the needs of their clients in a variety of settings.

The Development of Genetics in the Light of Thomas Kuhn's Theory of Scientific Revolutions.

PubMed

Portin, Petter

2015-01-01

The concept of a paradigm is in the key position in Thomas Kuhn's theory of scientific revolutions. A paradigm is the framework within which the results, concepts, hypotheses and theories of scientific research work are understood. According to Kuhn, a paradigm guides the working and efforts of scientists during the time period which he calls the period of normal science. Before long, however, normal science leads to unexplained matters, a situation that then leads the development of the scientific discipline in question to a paradigm shift--a scientific revolution. When a new theory is born, it has either gradually emerged as an extension of the past theory, or the old theory has become a borderline case in the new theory. In the former case, one can speak of a paradigm extension. According to the present author, the development of modern genetics has, until very recent years, been guided by a single paradigm, the Mendelian paradigm which Gregor Mendel launched 150 years ago, and under the guidance of this paradigm the development of genetics has proceeded in a normal fashion in the spirit of logical positivism. Modern discoveries in genetics have, however, created a situation which seems to be leading toward a paradigm shift. The most significant of these discoveries are the findings of adaptive mutations, the phenomenon of transgenerational epigenetic inheritance, and, above all, the present deeply critical state of the concept of the gene.

SeqAPASS: Sequence alignment to predict across-species susceptibility

EPA Science Inventory

Efforts to shift the toxicity testing paradigm from whole organism studies to those focused on the initiation of toxicity and relevant pathways have led to increased utilization of in vitro and in silico methods. Hence the emergence of high through-put screening (HTS) programs, s...

Teaching a changing paradigm in physiology: a historical perspective on gut interstitial cells.

PubMed

Drumm, Bernard T; Baker, Salah A

2017-03-01

The study and teaching of gastrointestinal (GI) physiology necessitates an understanding of the cellular basis of contractile and electrical coupling behaviors in the muscle layers that comprise the gut wall. Our knowledge of the cellular origin of GI motility has drastically changed over the last 100 yr. While the pacing and coordination of GI contraction was once thought to be solely attributable to smooth muscle cells, it is now widely accepted that the motility patterns observed in the GI tract exist as a result of a multicellular system, consisting of not only smooth muscle cells but also enteric neurons and distinct populations of specialized interstitial cells that all work in concert to ensure proper GI functions. In this historical perspective, we focus on the emerging role of interstitial cells in GI motility and examine the key discoveries and experiments that led to a major shift in a paradigm of GI physiology regarding the role of interstitial cells in modulating GI contractile patterns. A review of these now classic experiments and papers will enable students and educators to fully appreciate the complex, multicellular nature of GI muscles as well as impart lessons on how shifting paradigms in physiology are fueled by new technologies that lead to new emerging discoveries. Copyright © 2017 the American Physiological Society.

The Outsourcing of Classroom Instruction in Higher Education

ERIC Educational Resources Information Center

Schibik, Timothy; Harrington, Charles

2004-01-01

Many constituencies external to higher education have begun promoting greater accountability. This view advocates a closer focus on the bottom line and that universities should utilise a more business-like model. One major outgrowth of this paradigm shift has been the seemingly recent emergence of outsourcing in higher education. Higher education…

Evolution of Career Services in Higher Education

ERIC Educational Resources Information Center

Dey, Farouk; Cruzvergara, Christine Y.

2014-01-01

Socioeconomic changes, technological advances, and generational trends have been the impetus behind every major paradigm shift in the delivery of career services in higher education during the past century, including the one taking shape today. This chapter will provide an overview of the changing nature and emerging trends that are shaping the…

Remote monitoring of cardiovascular implanted electronic devices: a paradigm shift for the 21st century.

PubMed

Cronin, Edmond M; Varma, Niraj

2012-07-01

Traditional follow-up of cardiac implantable electronic devices involves the intermittent download of largely nonactionable data. Remote monitoring represents a paradigm shift from episodic office-based follow-up to continuous monitoring of device performance and patient and disease state. This lessens device clinical burden and may also lead to cost savings, although data on economic impact are only beginning to emerge. Remote monitoring technology has the potential to improve the outcomes through earlier detection of arrhythmias and compromised device integrity, and possibly predict heart failure hospitalizations through integration of heart failure diagnostics and hemodynamic monitors. Remote monitoring platforms are also huge databases of patients and devices, offering unprecedented opportunities to investigate real-world outcomes. Here, the current status of the field is described and future directions are predicted.

Asset-Based Assessment in Educational Psychology: Capturing Perceptions during a Paradigm Shift

ERIC Educational Resources Information Center

Lubbe, Carien; Eloff, Irma

2004-01-01

Several trends are compelling educational psychologists towards a philosophy of assessment that is asset-based and strength focused. This article shares the results from a study that explored perceptions about asset-based assessment in Educational Psychology in South Africa. Three focus groups were held and four main themes emerged from the…

Reflective Blogfolios in the Language Classroom: Impact on EFL Tertiary Students' Argumentative Writing Skills and Ways of Knowing

ERIC Educational Resources Information Center

Ammar, Abdullah Mahmoud Ismial

2016-01-01

The emerging paradigm shift in educational contexts from walled classroom environments to virtual, hybrid, blended, and lately personal learning environments has brought about vast changes in the foreign language classroom practices. Numerous calls for experimenting with new instructional treatments to enhance students' language performance in…

Pre-Service Teachers' Views on Web-Based Classroom Management

ERIC Educational Resources Information Center

Boyaci, Adnan

2010-01-01

With the invention of World Wide Web in 1992, delivery of distance education via internet and emergency of web-based classrooms have rapidly gained acceptance as an alternative and supplement to traditional face to face classroom instruction (Alavi, Yoo & Vogel, 1997; Rahm & Reed, 1997), which represents a paradigm shift challenging all…

Irish Educational Policy in the 1960s: A Decade of Transformation

ERIC Educational Resources Information Center

Fleming, Brian; Harford, Judith

2014-01-01

A decade of transformation that emerged following a period of inertia and insularity in Irish education, the 1960s is widely regarded by scholars as representing a paradigm shift in education policy. Marked by a more interventionist, strategic policy approach, this period resulted in significant democratisation of education, particularly at…

Promoting Leadership in the Ongoing Professional Development of Teachers: Responding to Globalization and Inclusion

ERIC Educational Resources Information Center

Philpott, David E.; Furey, Edith; Penney, Sharon C.

2010-01-01

This paper explores the need for innovative leadership in teacher education in the Canadian context, with a particular call for renewed professional development of current teachers. Within a country defined as multicultural, recent demographic shifts, interregional migration, growing ethnic diversity, and the emergence of a paradigm of inclusion,…

Day Service Provision for People with Intellectual Disabilities: A Case Study Mapping 15-Year Trends in Ireland

ERIC Educational Resources Information Center

Fleming, Padraic; McGilloway, Sinead; Barry, Sarah

2017-01-01

Background: Day services for people with intellectual disabilities are experiencing a global paradigm shift towards innovative person-centred models of care. This study maps changing trends in day service utilization to highlight how policy, emergent patterns and demographic trends influence service delivery. Methods: National intellectual…

The Living School: The Emergence of a Transformative Sustainability Education Paradigm

ERIC Educational Resources Information Center

O'Brien, Catherine; Howard, Patrick

2016-01-01

Education, as it was initially organized in the late nineteenth and early twentieth centuries, was designed to meet very different challenges than those we face today. There have been many efforts to shift education to address new contexts that result from societal transformation. There have also been international initiatives in response to…

Cancer research in need of a scientific revolution: Using 'paradigm shift' as a method of investigation.

PubMed

Wion, Didier; Appaix, Florence; Burruss, Meriwether; Berger, Francois; van der Sanden, Boudewijn

2015-09-01

Despite important human and financial resources and considerable accumulation of scientific publications, patents, and clinical trials, cancer research has been slow in achieving a therapeutic revolution similar to the one that occurred in the last century for infectious diseases. It has been proposed that science proceeds not only by accumulating data but also through paradigm shifts. Here, we propose to use the concept of 'paradigm shift' as a method of investigation when dominant paradigms fail to achieve their promises. The first step in using the 'paradigm shift' method in cancer research requires identifying its founding paradigms. In this review, two of these founding paradigms will be discussed: (i) the reification of cancer as a tumour mass and (ii) the translation of the concepts issued from infectious disease in cancer research. We show how these founding paradigms can generate biases that lead to over-diagnosis and over-treatment and also hamper the development of curative cancer therapies. We apply the 'paradigm shift' method to produce perspective reversals consistent with current experimental evidence. The 'paradigm shift' method enlightens the existence of a tumour physiologic-prophylactic-pathologic continuum. It integrates the target/antitarget concept and that cancer is also an extracellular disease. The 'paradigm shift' method has immediate implications for cancer prevention and therapy. It could be a general method of investigation for other diseases awaiting therapy.

Psychoneuroimmunology and cancer: A decade of discovery, paradigm shifts, and methodological innovations

PubMed Central

McDonald, Paige Green; O’Connell, Mary; Lutgendorf, Susan K.

2013-01-01

This article introduces the supplemental issue of “Cancer, Brain, Behavior, and Immunity” and outlines important discoveries, paradigm shifts, and methodological innovations that have emerged in the past decade to advance mechanistic and translational understanding of biobehavioral influences on tumor biology, cancer treatment-related sequelae, and cancer outcomes. We offer a heuristic framework for research on biobehavioral pathways in cancer. The shifting survivorship landscape is highlighted and we propose that the changing demographics suggest prudent adoption of a life course perspective of cancer and cancer survivorship. We note opportunities for psychoneuroimmunology (PNI) research to ameliorate the long-term, unintended consequences of aggressive curative intent and call attention to the critical role of reciprocal translational pathways between animal and human studies. Lastly, we briefly summarize the articles included in this compilation and offer our perspectives on future research directions. HighlightsThis article introduces the National Cancer Institute sponsored special issue Cancer, Brain, Behavior, and Immunity and highlights the last decade of PNI-cancer research. PMID:23333846

Emerging New Physics with Major Implications for Energy Technology, Biology, and Medicine

NASA Astrophysics Data System (ADS)

Mallove, Eugene F.

2003-03-01

In the past 15 years, reproducible experiments and prototype technological devices have emerged that may revolutionize much of physics and chemistry(despite the common perception that modern physics is on very solid ground and is nearing a "Theory of Everything"). This new physics has flourished despite very strong opposition by the entrenched foundational paradigms within physics and chemistry ( not to forget vested financial interests within academia). In fact, beginning with "cold fusion" (more generically low-energy nuclear reactions, LENR), one of the most important discoveries of the late 20th Century has been the irrefutable proof of the failure of the physics establishment to deal ethically and appropriately with potential and real paradigm shifts, when its "sacred writ" ( i.e. Its textbooks) -- are threatened with the need for massive revision.

Distributive Leadership in Public Schools: Experiences and Perceptions of Teachers in the Soweto Region

ERIC Educational Resources Information Center

Naicker, Suraiya R.; Mestry, Raj

2011-01-01

In current times, the increasing demands of principalship and the complexities facing schools have led to the emergence of distributive forms of leadership in schools. The dissatisfaction with traditional models has resulted in a paradigm shift where leadership focus on the position of individuals in the hierarchy has been rejected in favour of…

Changing resource management paradigms, traditional ecological knowledge, and non-timber forest products

Treesearch

Iain J. Davidson-Hunt; Fikret Berkes

2001-01-01

We begin this paper by exploring the shift now occurring in the science that provides the theoretical basis for resource management practice. The concepts of traditional ecological knowledge and traditional management systems are presented next to provide the background for an examination of resilient landscapes that emerge through the work and play of humans. These...

Response to Elvira Panaiotidi, "The Nature of Paradigms and Paradigm Shifts in Music Education"

ERIC Educational Resources Information Center

Kurkul, Wenyi W.

2005-01-01

In her paper, Panaiotidi discusses the debate over the approaches in music education by Reimer and Elliott in the context of paradigm shifts. The term, "paradigm shift," was introduced by Thomas Kuhn in 1962 in his highly influential book, "The Structure of Scientific Revolutions." In this article, the author believes that what…

Emergency managers as community change agents: an expanded vision of the profession.

PubMed

Drabek, Thomas E

2014-01-01

Reflecting the historical evolution of attack preparedness, technological failures, and so-called natural disaster events, the profession of emergency management confronts new challenges today. In part, these reflect important cultural differences among stakeholder groups, especially local emergency managers. homeland security personnel, and those focused on public health threats and business continuity. An expanded and more strategic vision of the profession is required wherein fundamental assumption sets are placed into broader contexts. Contrary to the drift experienced in the US during the past decade, a major paradigm shift is required reflecting new orientations and program priorities.

Seismic Overstatement: Challenging the Paradigm Shift in Composition.

ERIC Educational Resources Information Center

Bell, James

1995-01-01

Discusses Maxine Hairston's appropriation in 1982 of Thomas Kuhn's epistemology and his concept of "paradigm shift." Argues that the paradigm shift must be treated as an enabling fiction through which members of the professional can speculate on better ways to teach students. (SR)

Where Children Live: Solutions for Serving Young Children and Their Families. Advances in Applied Developmental Psychology, Volume 17.

ERIC Educational Resources Information Center

Roberts, Richard N., Ed.; Magrab, Phyllis R., Ed.

The changing nature of communities necessitates a comprehensive theoretical model for effective delivery of child and family services. This edited volume provides a context for and examples of an emerging paradigm shift in human services toward one in which services for families with young children are provided in their communities. Section 1 of…

Networking switches for smart functions using copper signaling and dynamic heteroleptic complexation.

PubMed

Schmittel, Michael

2018-04-17

This personal frontier account describes our recent progress in networking nanoswitches to generate emergent functions, such as catalytic machinery, and identifies the key impediments in mastering the paradigm shift from pure compounds to smart mixtures. A crucial challenge is the setup of reliable signaling protocols that are based on highly selective metal ion translocation and metal-ligand receptor events.

Philosophy of science and the emerging paradigm: implications for hypnosis.

PubMed

Osowiec, Darlene A

2014-01-01

Within the hypnosis field, there is a disparity between clinical and research worldviews. Clinical practitioners work with patients who are dealing with serious, often unique, real-world problems-lived experience. Researchers adhere to objective measurements, standardization, data, and statistics. Although there is overlap, an ongoing divergence can be counterproductive to the hypnosis field and to the larger professional and social contexts. The purpose of this article is: (1) to examine some of the major assumptions, the history, and the philosophy that undergird the definition of science, which was constructed in the mid-17th century; (2) to discover how science is a product of prevailing social forces and is undergoing a paradigm shift; and (3) to understand the more encompassing, holistic paradigm with implications for the hypnosis field.

Paradigm Shift: Understanding and Implementing Change in Second Language Education.

ERIC Educational Resources Information Center

Jacobs, George M.; Farrell, Thomas

2001-01-01

Describes eight changes that fit the paradigm shift in second language education toward what is often called communicative language teaching: learner autonomy, cooperative learning, curricular integration, focus on meaning, diversity, thinking skills, alternative assessment, and teachers as co-learners. The paradigm shift is examined as an element…

Sepsis is a preventable public health problem.

PubMed

Kempker, Jordan A; Wang, Henry E; Martin, Greg S

2018-05-06

There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework for sepsis as a public health problem by adapting the traditional model of primary, secondary, and tertiary prevention.

Researching Style: Epistemology, Paradigm Shifts and Research Interest Groups

ERIC Educational Resources Information Center

Rayner, Stephen

2011-01-01

This paper identifies the need for a deliberate approach to theory building in the context of researching cognitive and learning style differences in human performance. A case for paradigm shift and a focus upon research epistemology is presented, building upon a recent critique of style research. A proposal for creating paradigm shift is made,…

Paradigm Shift: Understanding and Implementing Change in Second Language Education

ERIC Educational Resources Information Center

Jacobs, George M.; Farrell, Thomas S. C.

2001-01-01

Change seems to be a constant in education. We can better understand and implement change in second language education if we look for connections between changes. The concept of paradigm shift offers one means of making such connections. This article describes eight changes that fit with the paradigm shift in second language education toward what…

A sustainable system of systems approach: a new HFE paradigm.

PubMed

Thatcher, Andrew; Yeow, Paul H P

2016-01-01

Sustainability issues such as natural resource depletion, pollution and poor working conditions have no geographical boundaries in our interconnected world. To address these issues requires a paradigm shift within human factors and ergonomics (HFE), to think beyond a bounded, linear model understanding towards a broader systems framework. For this reason, we introduce a sustainable system of systems model that integrates the current hierarchical conceptualisation of possible interventions (i.e., micro-, meso- and macro-ergonomics) with important concepts from the sustainability literature, including the triple bottom line approach and the notion of time frames. Two practical examples from the HFE literature are presented to illustrate the model. The implications of this paradigm shift for HFE researchers and practitioners are discussed and include the long-term sustainability of the HFE community and comprehensive solutions to problems that consider the emergent issues that arise from this interconnected world. A sustainable world requires a broader systems thinking than that which currently exists in ergonomics. This study proposes a sustainable system of systems model that incorporates ideas from the ecological sciences, notably a nested hierarchy of systems and a hierarchical time dimension. The implications for sustainable design and the sustainability of the HFE community are considered.

[Is the brain the creator of psychic phenomena or is a paradigm shift inevitable?].

PubMed

Bonilla, Ernesto

2014-06-01

Every day new scientific information is appearing that cannot be explained using the classical Newtonian model and is calling for the emergence of a new paradigm that would include the explanation of such phenomena as telepathy, clairvoyance, presentiment, precognition, out of the body experiences, psychic healing, after-death communication, near-death experiences and reincarnation. The materialist paradigm which considers the brain as the sole cause of consciousness and psychic phenomena has been challenged by a new paradigm that seems to demonstrate that there is not a cause-effect relationship between brain activity and psychic phenomena but only a correlation between them, since these phenomena can be experienced without the body and appear to have an extra-cerebral origin (cosmic field, cosmic consciousness?). Of course, the brain is intensely involved in the manifestation of consciousness in our daily life but this is not equivalent to affirm that brain creates consciousness. Recent findings force us to consider a non-physical, spiritual and transpersonal aspect of reality.

Human Resource Development for Knowledge-based Society and Challenges of Nagoya University

NASA Astrophysics Data System (ADS)

Miyata, Takashi

Innovation in the previous century resulted in development of useful products ranging from automobiles and aircraft to cellular phones. However, the innovation and development of science and technology have changed the society and brought about negative issues. The issues emerged in the previous century remain in the excessive forms in the 21st century. The 21st century is seeing the rise of knowledge-based society, and paradigm shift is now going on. Human resources of university for creation of innovation are being called on to contribute to solving issues. Young people who pass through a doctor program must play a role as an innovator who can promote the paradigm shift. However, the higher education system of the universities in Japan is now required to be changed to dissolve the mismatch on the doctor program with industries, government and students. The discussion in the Business-University Forum of Japan for innovation of education system and a few challenges of the Nagoya University are introduced in this paper.

A Qualitative Approach to Integrative WAC.

ERIC Educational Resources Information Center

Siebert, Debbie L.

Many educators and researchers are discussing a shift in national education from an "instruction" paradigm emphasizing measuring inputs and providing instruction to a "learning" paradigm emphasizing outputs and producing learning. The question is how can Writing Across the Curriculum (WAC) smoothly shift educational paradigms.…

Mr. ATOD's wild ride: what do alcohol, tobacco, and other drugs have in common?

PubMed

Courtwright, David T

2005-01-01

All researchers agree that individuals can become intoxicated by and dependent on alcohol, tobacco, and other psychoactive drugs. But they have disagreed over whether, and to what extent, drug pathologies comprise a unitary medical problem. Most critically, does addiction have a biological common denominator? Consensus on this question has shifted back and forth. In the late nineteenth and early twentieth centuries, physicians often studied and treated various drug addictions together, working under the "inebriety" paradigm. By the mid-twentieth century the inebriety paradigm had collapsed. Tobacco and alcohol had split off, both in the medical research community and in western popular culture. This article argues that neuroscientific, genetic, epidemiological, and historical evidence helped to reunify the addiction field in the late twentieth century. A new unifying paradigm emerged, variously called chemical dependency, substance abuse, or simply ATOD -- alcohol, tobacco, and other drugs.

The evolving war on cancer.

PubMed

Haber, Daniel A; Gray, Nathanael S; Baselga, Jose

2011-04-01

Building on years of basic scientific discovery, recent advances in the fields of cancer genetics and medicinal chemistry are now converging to revolutionize the treatment of cancer. Starting with serendipitous observations in rare subsets of cancer, a paradigm shift in clinical research is poised to ensure that new molecular insights are rapidly applied to shape emerging cancer therapies. Could this mark a turning point in the "War on Cancer"? Copyright © 2011 Elsevier Inc. All rights reserved.

Allied health professionals with 2020 vision.

PubMed

Miller, Thomas W; Gallicchio, Vincent S

2007-01-01

Allied health professionals in all disciplines must be visionary as they address education, training, and health care delivery in the next decade. Examined herein are forces of change in education, training, health care, the recognition of essential leadership styles, and the paradigm shifts facing the allied health profession in the health care arena. Some visionary directions are offered for allied health professionals to consider as health policy and clinical agendas emerge toward the year 2020.

The British Columbia Emergency Medicine Network: A Paradigm Shift in a Provincial System of Emergency Care.

PubMed

Abu-Laban, Riyad B; Drebit, Sharla; Lindstrom, Ronald R; Archibald, Chantel; Eggers, Kim; Ho, Kendall; Khazei, Afshin; Lund, Adam; MacKinnon, Carolyn; Markham, Ray; Marsden, Julian; Martin, Ed; Christenson, Jim

2018-01-04

As generalists, emergency practitioners face challenges in providing state-of-the-art care owing to the broad spectrum of practice and the rapid rate of new knowledge generation. Networks have become increasingly prevalent in health care, and it was in this backdrop, and the resulting opportunity to advance evidence-informed emergency care in the Canadian province of British Columbia (BC), that a new "Emergency Medicine Network" (EM Network) was launched in 2017. The EM Network consists of four programs, each led by a physician with expertise and a track record in the domain: (1) Clinical Resources; (2) Innovation; (3) Continuing Professional Development; and (4) Real-time Support. This paper provides an overview of the EM Network, including its background, purpose, programs, anticipated evolution, and impact on the BC health care system.

The British Columbia Emergency Medicine Network: A Paradigm Shift in a Provincial System of Emergency Care

PubMed Central

Abu-Laban, Riyad B; Lindstrom, Ronald R; Archibald, Chantel; Eggers, Kim; Ho, Kendall; Khazei, Afshin; Lund, Adam; MacKinnon, Carolyn; Markham, Ray; Marsden, Julian; Martin, Ed; Christenson, Jim

2018-01-01

As generalists, emergency practitioners face challenges in providing state-of-the-art care owing to the broad spectrum of practice and the rapid rate of new knowledge generation. Networks have become increasingly prevalent in health care, and it was in this backdrop, and the resulting opportunity to advance evidence-informed emergency care in the Canadian province of British Columbia (BC), that a new “Emergency Medicine Network” (EM Network) was launched in 2017. The EM Network consists of four programs, each led by a physician with expertise and a track record in the domain: (1) Clinical Resources; (2) Innovation; (3) Continuing Professional Development; and (4) Real-time Support. This paper provides an overview of the EM Network, including its background, purpose, programs, anticipated evolution, and impact on the BC health care system. PMID:29531875

Serotonergic and dopaminergic modulation of attentional processes.

PubMed

Boulougouris, Vasileios; Tsaltas, Eleftheria

2008-01-01

Disturbances in attentional processes are a common feature of several psychiatric disorders such as schizophrenia, attention deficit/hyperactivity disorder and Huntington's disease. The use of animal models has been useful in defining various candidate neural systems thus enabling us to translate basic laboratory science to the clinic and vice-versa. In this chapter, a comparative and integrated account is provided on the neuroanatomical and neurochemical modulation of basic behavioural operations such as selective attention, vigilance, set-shifting and executive control focusing on the comparative functions of the serotonin and dopamine systems in the cognitive control exerted by the prefrontal cortex. Specifically, we have reviewed evidence emerging from several behavioural paradigms in experimental animals and humans each of which centres on a different aspect of the attentional function. These paradigms offering both human and animal variants include the five-choice serial reaction time task (5CSRTT), attentional set-shifting and stop-signal reaction time task. In each case, the types of operation that are measured by the given paradigm and their neural correlates are defined. Then, the role of the ascending dopaminergic and serotonergic systems in the neurochemical modulation of its behavioural output are examined, and reference is made to clinical implications for neurological and neuropsychiatric disorders which exhibit deficits in these cognitive tests.

Implications for Teacher Effectiveness Research in Deaf Education from the Cognitive Paradigm.

ERIC Educational Resources Information Center

Mertens, Donna M.

The paper identifies a paradigm shift in research on teaching effectiveness from the process-product approach to explanations from cognitive psychology related to mediating variables which intervene between teacher behavior and pupil performance. Implications of this paradigm shift for research on the effectiveness of teachers of deaf students are…

Paradigm shift: contribution of field epidemiology training in advancing the “One Health” approach to strengthen disease surveillance and outbreak investigations in Africa

PubMed Central

Monday, Busuulwa; Gitta, Sheba Nakacubo; Wasswa, Peter; Namusisi, Olivia; Bingi, Aloysius; Musenero, Monica; Mukanga, David

2011-01-01

The occurrence of major zoonotic disease outbreaks in Sub-Saharan Africa has had a significant impact on the already constrained public health systems. This has, as a result, justified the need to identify creative strategies to address threats from emerging and re-emerging infectious diseases at the human-animal-environmental interface, and implement robust multi-disease public health surveillance systems that will enhance early detection and response. Additionally, enhanced reporting and timely investigation of all suspected notifiable infectious disease threats within the health system is vital. Field epidemiology and laboratory training programs (FELTPs) have made significant contributions to public health systems for more than 10 years by producing highly skilled field epidemiologists. These epidemiologists have not only improved disease surveillance and response to outbreaks, but also improved management of health systems. Furthermore, the FETPs/FELTPs have laid an excellent foundation that brings clinicians, veterinarians, and environmental health professionals drawn from different governmental sectors, to work with a common purpose of disease control and prevention. The emergence of the One Health approach in the last decade has coincided with the present, paradigm, shift that calls for multi-sectoral and cross-sectoral collaboration towards disease surveillance, detection, reporting and timely response. The positive impact from the integration of FETP/FELTP and the One Health approach by selected programs in Africa has demonstrated the importance of multi-sectoral collaboration in addressing threats from infectious and non- infectious causes to man, animals and the environment. PMID:22359701

2001: Things to come.

PubMed

Apuzzo, M L; Liu, C Y

2001-10-01

THIS ARTICLE DISCUSSES elements in the definition of modernity and emerging futurism in neurological surgery. In particular, it describes evolution, discovery, and paradigm shifts in the field and forces responsible for their realization. It analyzes the cyclical reinvention of the discipline experienced during the past generation and attempts to identify apertures to the near and more remote future. Subsequently, it focuses on forces and discovery in computational science, imaging, molecular science, biomedical engineering, and information processing as they relate to the theme of minimalism that is evident in the field. These areas are explained in the light of future possibilities offered by the emerging field of nanotechnology with molecular engineering.

CERN: A global project

NASA Astrophysics Data System (ADS)

Voss, Rüdiger

2017-07-01

In the most important shift of paradigm of its membership rules in 60 years, CERN in 2010 introduced a policy of “Geographical Enlargement” which for the first time opened the door for membership of non-European States in the Organization. This short article reviews briefly the history of CERN’s membership rules, discusses the rationale behind the new policy, its relationship with the emerging global roadmap of particle physics, and gives a short overview of the status of the enlargement process.

[The end of discrimination in social security for the elderly? Some remarks on the consequences of the paradigm shift in a life course perspective on gender].

PubMed

Fachinger, Uwe

2008-10-01

Trying to analyse the effects of the paradigm shift in the old age social security system in Germany (GRV) from a life cycle gender perspective yields light and shade - it is a conglomeration of individual- and family-specific transfers, financed by a mix of contributions and taxes, and with measures of explicit and implicit, intended and not intended ex-post and ex-ante redistribution and discrimination.The paradigm shift has increased the complexity of the system and created additional elements of gender specific discrimination as well as reduced established elements of the so called "social compensation". Furthermore, the relevance of complementary private and occupational pensions will increase absolute and relative due to the reduction of the pension level. This will raise the importance of earnings in old age especially those that are without any elements of social security compensation or without elements of recognition of activities beside employment. Overall the paradigm shift has intensified the discrimination of women in two ways and the pension privatisation has caused redistribution from the bottom to the top. In other words, there is an increase in inter- and intra-gender discrimination. Due to the changes and the emphasis of aspects of an independent old age security savings for women the norm of the "male breadwinner model" has increased. The importance of "providing one's own pension" additionally creates distribution conflicts within a partnership. Because of the necessity of constant payments over time within a private insurance and the changes of an individual income and gender-specific life cycle, conflicts may occur time and again. The dependence of life-long partnerships on each other is not reduced or abolished with the strengthening of the individualistic model of protection, but is qualitatively and quantitatively improved. Against this background, the measures of the statutory pension system which are aimed towards the situation of a woman's life are important factors to combat the disadvantages of private funded pension systems of which mainly women are affected in building up rights to future benefits. The analysis shows that the paradigm shift primarily brings disadvantages to women. They disproportionally depend on statutory pension system benefits, and therefore also on compensating benefits of the negative consequences of private and occupational pension systems. For the future an increase in poverty of older people - and especially women - can be seen to emerge because of pension privatisation and the reduction of the pension level in the German social security system.

Eleanor Clarke Slagle Lectureship, 1984: transformation of a profession.

PubMed

Gilfoyle, E M

1984-09-01

Professional evolution includes a period of disunity, a phase when old values and concepts are being examined, and new perspectives emerge. Disunity can be a positive impetus for dynamic change. Transformation provides a higher level reintegration through which new understanding and progress unfold. Occupational therapy's transformation is now; it is time for careful analysis and creative synthesis. Transformation is a three-fold process of integration of past, present, and future into an upward spiral of professional development. Transformation is a constant flow of activities influenced by both internal and external factors. Although there are multidimensions that influence occupational therapy's transformation, three major components are inherent in the profession's paradigm shift: society's decline in patriarchal authority; decline in allegiance to a biomedical model; and shift in values, dimensions of practice, and education that form the reality of occupational therapy. Transformation of our profession will be a paradigm shift: in our value system of purposeful activity to a new perspective of occupation and occupational, in our quest to develop a unifying theory for recognition of the unifying force of values, in our concepts and theories to include the science of occupation and the art of purposefulness from total allegiance to scientific knowledge to include intuitive knowledge, from being an allied medical field to an independent health profession that is both educationally and medically related, from a biomedical model to a paradigm of wellness, in balancing of feminine and masculine values of human nature in organizing educational curricula and entry-level requirements that reflect our value system and predicted practice dimensions.

Ghost and self: Jung's paradigm shift and a response to Zinkin.

PubMed

Rowland, Susan

2009-11-01

Zinkin's lucid challenge to Jung makes perfect sense. Indeed, it is the implications of this 'making sense' that this paper addresses. For Zinkin's characterization of the 'self' takes it as a 'concept' requiring coherence; a variety of abstract non-contextual knowledge that itself has a mythical heritage. Moreover, Zinkin's refinement of Jung seeks to make his work fit for the scientific paradigm of modernity. In turn, modernity's paradigm owes much to Newton's notion of knowledge via reductionism. Here knowledge or investigation is divided up into the smallest possible units with the aim of eventually putting it all together into 'one' picture of scientific truth. Unfortunately, 'reductionism' does not do justice to the resonant possibilities of Jung's writing. These look forward to a new scientific paradigm of the twenty-first century, of the interactive 'field', emergence and complexity theory. The paper works paradoxically by discovering Zinkin's 'intersubjective self' after all, in two undervalued narratives by Jung, his doctoral thesis and a short late ghost story. However, in the ambivalences and radical fictional experimentation of these fascinating texts can be discerned an-Other self, one both created and found.

Paradigm Lost: The Human Chromosome Story.

ERIC Educational Resources Information Center

Unger, Lawrence; Blystone, Robert V.

1996-01-01

Discusses whether the discovery in 1956 that humans have a chromosome number of 46, as opposed to 47 or 48 as previously thought, fits into a paradigm shift of the Kuhnian type. Concludes that Kuhn probably would not have considered the chromosome number shift to be large enough to be a focus for one of his paradigms. (AIM)

The HOCS paradigm shift from disciplinary knowledge (LOCS)--to interdisciplinary evaluative, system thinking (HOCS): what should it take in science-technology-environment-society oriented courses, curricula and assessment?

PubMed

Zoller, U; Scholz, R W

2004-01-01

Given the current world state of affairs, striving for sustainability and the consequent paradigm shift: growth-to-sustainable development, correction-to-prevention and options selection-to-options generation: the corresponding paradigm shift in science-technology-environment-society (STES) education is unavoidable. Accordingly, the essence of the current reform in STES education, worldwide, is a purposed effort to develop students' higher-order cognitive skills (HOCS) capability; i.e., question-asking, critical system thinking, decision making and problem solving, at the expense of the "delivery" of lower-order cognitive skills (LOCS)-oriented knowledge. This means a paradigm shift from the contemporary prevalent LOCS algorithmic teaching to HOCS evaluative learning and HOCS-promoting courses, curricula, teaching strategies and assessment methodologies, leading, hopefully to evaluative thinking and transfer. Following the formulation of selected relevant axioms, major paradigm shift in STES research and education for sustainability have been identified. The consequent shift, in the STES context, from disciplinary to inter- and transdisciplinary learning, in science technology and environmental engineering education is discussed, followed by selected examples of successfully implemented HOCS-promoting courses, and assessment methodologies. It is argued, that transferable "HOCS learning" for sustainability can and should be done.

Animal-Free Chemical Safety Assessment

PubMed Central

Loizou, George D.

2016-01-01

The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with the emerging digital medical world of omics data, biosensors and advanced imaging which offers the increasingly realistic prospect of personalized medicine. Described as a potential “seismic” shift from the current “healthcare” model to a “wellness” paradigm that is predictive, preventative, personalized and participatory, this change is based on the development of increasingly sophisticated biosensors which can track and measure key biochemical variables in people. Additional key drivers in this shift are metabolomic and proteomic signatures, which are increasingly being reported as pre-symptomatic, diagnostic and prognostic of toxicity and disease. These advancements also have profound implications for toxicological evaluation and safety assessment of pharmaceuticals and environmental chemicals. An approach based primarily on human in vivo and high-throughput in vitro human cell-line data is a distinct possibility. This would transform current chemical safety assessment practice which operates in a human “data poor” to a human “data rich” environment. This could also lead to a seismic shift from the current animal-based to an animal-free chemical safety assessment paradigm. PMID:27493630

Bio-threat preparedness: Need for a paradigm shift.

PubMed

Jindal, A K; Roy, Kaushik

2014-04-01

India of late has been vulnerable to Chemical, Biological, Radiological and Nuclear (CBRN) threat, on account of its unique geographic position. Biological threat is an imminent threat in the hands of a terrorist. The public health system of our country is overburdened due to its present role and bio-attack response is not a priority area. This paper suggests that as the prime focus is on the CR and N threats in the integrated CBRN preparedness strategy and that specialized and technical forces are needed to deal with a bio-threat; hence there is a need for a paradigm shift in policy. The emerging field of bio-threat needs to be delinked from the joint family of 'CBRN', with consequent structural and functional changes. A separate specialized cadre needs to be formed for dealing with bio-threat, created from the pool of doctors and non-medical scientists from the AFMS and the DRDO. Structural changes are needed in the organization, to bring in the resources of NCDC, New Delhi for enhanced disease surveillance capacity and creation of a bio-threat mitigation node in the AFMC, Pune.

Urban Stormwater Governance: The Need for a Paradigm Shift.

PubMed

Dhakal, Krishna P; Chevalier, Lizette R

2016-05-01

Traditional urban stormwater management involves rapid removal of stormwater through centralized conveyance systems of curb-gutter-pipe networks. This results in many adverse impacts on the environment including hydrological disruption, groundwater depletion, downstream flooding, receiving water quality degradation, channel erosion, and stream ecosystem damage. In order to mitigate these adverse impacts, urban stormwater managers are increasingly using green infrastructure that promote on-site infiltration, restore hydrological functions of the landscape, and reduce surface runoff. Existing stormwater governance, however, is centralized and structured to support the conventional systems. This governance approach is not suited to the emerging distributed management approach, which involves multiple stakeholders including parcel owners, government agencies, and non-governmental organizations. This incongruence between technology and governance calls for a paradigm shift in the governance from centralized and technocratic to distributed and participatory governance. This paper evaluates how five US cities have been adjusting their governance to address the discord. Finally, the paper proposes an alternative governance model, which provides a mechanism to involve stakeholders and implement distributed green infrastructure under an integrative framework.

Caring for patients with kidney disease: shifting the paradigm from evidence-based medicine to patient-centered care

PubMed Central

O'Hare, Ann M.; Rodriguez, Rudolph A.; Bowling, Christopher Barrett

2016-01-01

The last several decades have witnessed the emergence of evidence-based medicine as the dominant paradigm for medical teaching, research and practice. Under an evidence-based approach, populations rather than individuals become the primary focus of investigation. Treatment priorities are largely shaped by the availability, relevance and quality of evidence and study outcomes and results are assumed to have more or less universal significance based on their implications at the population level. However, population-level treatment goals do not always align with what matters the most to individual patients—who may weigh the risks, benefits and harms of recommended treatments quite differently. In this article we describe the rise of evidence-based medicine in historical context. We discuss limitations of this approach for supporting real-world treatment decisions—especially in older adults with confluent comorbidity, functional impairment and/or limited life expectancy—and we describe the emergence of more patient-centered paradigms to address these limitations. We explain how the principles of evidence-based medicine have helped to shape contemporary approaches to defining, classifying and managing patients with chronic kidney disease. We discuss the limitations of this approach and the potential value of a more patient-centered paradigm, with a particular focus on the care of older adults with this condition. We conclude by outlining ways in which the evidence-base might be reconfigured to better support real-world treatment decisions in individual patients and summarize relevant ongoing initiatives. PMID:25637639

Misrepresenting Religious Education's Past and Present in Looking Forward: Gearon Using Kuhn's Concepts of Paradigm, Paradigm Shift and Incommensurability

ERIC Educational Resources Information Center

Jackson, Robert

2015-01-01

In looking to the future, some writers on religious education (RE) have attempted to evaluate current approaches to the subject. Some have characterised any significant change in approach as a "paradigm shift", a term derived from Thomas Kuhn's work in the philosophy of science. This article examines the uses of the terms…

CERN: A European laboratory for a global project

NASA Astrophysics Data System (ADS)

Voss, Rüdiger

2015-06-01

In the most important shift of paradigm of its membership rules in 60 years, CERN in 2010 introduced a policy of “Geographical Enlargement” which for the first time opened the door for membership of non-European States in the Organization. This short article reviews briefly the history of CERN's membership rules, discusses the rationale behind the new policy, its relationship with the emerging global roadmap of particle physics, and gives a short overview of the status of the enlargement process.

Engineering Biomaterials to Integrate and Heal: The Biocompatibility Paradigm Shifts

PubMed Central

Bryers, James D.; Giachelli, Cecilia M.; Ratner, Buddy D.

2012-01-01

This article focuses on one of the major failure routes of implanted medical devices, the foreign body reaction (FBR)—that is, the phagocytic attack and encapsulation by the body of the so-called “biocompatible” biomaterials comprising the devices. We then review strategies currently under development that might lead to biomaterial constructs that will harmoniously heal and integrate into the body. We discuss in detail emerging strategies to inhibit the FBR by engineering biomaterials that elicit more biologically pertinent responses. PMID:22592568

Periodontology in the age of inflammation: a changing landscape.

PubMed

Cochran, David

2009-01-01

It has been known for some time that relationships exist between periodontal disease and other medical conditions such as cardiovascular disease, diabetes, kidney disease, and rheumatoid arthritis. Recent research is demonstrating that periodontal disease is the result of host inflammatory reaction to bacterial infection. This conceptual paradigm shift has lead to renewed need to educate patients about the importance of oral health and to collaborations with medical colleagues through consensus conferences where the results of emerging research are translated into practice guidelines.

Paradigm Shifts in Ophthalmic Diagnostics*

PubMed Central

Sebag, J.; Sadun, Alfredo A.; Pierce, Eric A.

2016-01-01

Purpose Future advances in ophthalmology will see a paradigm shift in diagnostics from a focus on dysfunction and disease to better measures of psychophysical function and health. Practical methods to define genotypes will be increasingly important and non-invasive nanotechnologies are needed to detect molecular changes that predate histopathology. Methods This is not a review nor meant to be comprehensive. Specific topics have been selected to illustrate the principles of important paradigm shifts that will influence the future of ophthalmic diagnostics. It is our impression that future evaluation of vision will go beyond visual acuity to assess ocular health in terms of psychophysical function. The definition of disease will incorporate genotype into what has historically been a phenotype-centric discipline. Non-invasive nanotechnologies will enable a paradigm shift from disease detection on a cellular level to a sub-cellular molecular level. Results Vision can be evaluated beyond visual acuity by measuring contrast sensitivity, color vision, and macular function, as these provide better insights into the impact of aging and disease. Distortions can be quantified and the psychophysical basis of vision can be better evaluated than in the past by designing tests that assess particular macular cell function(s). Advances in our understanding of the genetic basis of eye diseases will enable better characterization of ocular health and disease. Non-invasive nanotechnologies can assess molecular changes in the lens, vitreous, and macula that predate visible pathology. Oxygen metabolism and circulatory physiology are measurable indices of ocular health that can detect variations of physiology and early disease. Conclusions This overview of paradigm shifts in ophthalmology suggests that the future will see significant improvements in ophthalmic diagnostics. The selected topics illustrate the principles of these paradigm shifts and should serve as a guide to further research and development. Indeed, successful implementation of these paradigm shifts in ophthalmology may provide useful guidance for similar developments in all of healthcare. PMID:28008209

Shifting Paradigms in Music Education Research (1953-1978): A Theoretical and Quantitative Reassessment

ERIC Educational Resources Information Center

Jorgensen, Estelle R.; Ward-Steinman, Patrice Madura

2015-01-01

The purpose of this study was to examine evidence of a hypothesized shift in the operative research paradigms in music education during the first quarter century of the publication of the "Journal of Research in Music Education," during the period 1953 to 1978. This shift was from humanities-oriented historical and philosophical studies…

Emerging technologies in healthcare: navigating risks, evaluating rewards.

PubMed

McGrady, Elizabeth; Conger, Sue; Blanke, Sandra; Landry, Brett J L

2010-01-01

The purpose of this prescriptive research is to help decision makers become better informed about three technologies emerging in the healthcare arena by providing a basic description of the technology and describing their current applications, future healthcare deployment, potential risks, and related managerial issues. Two of the technologies, radio frequency identification (RFID) and global positioning systems (GPS), are currently available to healthcare organizations and appear capable of decreasing cost but may require significant initial investment and have disruptive potential. The third technology, nanotechnology, has limited current use but may revolutionize both the delivery of medicine and hospital infrastructure management. With cautious attention to managerial issues and meticulous attention to implementation details, healthcare organizations that can successfully navigate the coming technologically driven paradigm shifts will emerge more resilient organizations.

Educating the Psychology Workforce in the Age of the Affordable Care Act: A Graduate Course Modeled after the Priorities of the Patient-Centered Outcomes Research Institute (PCORI)

PubMed Central

Hoerger, Michael

2015-01-01

The Affordable Care Act (ACA) represents a paradigm shift in the U.S. healthcare system, which has implications for psychology programs producing the next generation of trainees. In particular, the ACA has established the Patient-Centered Outcomes Research Institute (PCORI), which has been tasked with developing national priorities and funding research aimed at improving healthcare quality by helping patients and providers to make informed healthcare decisions. PCORI's national priorities span five broad domains: person-centered outcomes research, health disparities research, healthcare systems research, communication and dissemination research, and methodologic research. As these national priorities overlap with the knowledge and skills often emphasized in psychology training programs, initiatives by training programs to bolster strengths in these domains could place trainees at the forefront of this emerging research paradigm. As a part of a new Masters program in behavioral health, our program developed a health psychology course modeled around PCORI's five national priorities, and an initial evaluation in a small sample supported student learning in the five PCORI domains. In summary, the current report has implications for familiarizing readers with PCORI's national priorities for U.S. healthcare, stimulating debate surrounding psychology's response to the largest healthcare paradigm shift in recent U.S. history, and providing a working model for programs seeking to implement PCORI-related changes to their curricula. PMID:26843899

Arctic systems in the Quaternary: ecological collision, faunal mosaics and the consequences of a wobbling climate.

PubMed

Hoberg, E P; Cook, J A; Agosta, S J; Boeger, W; Galbreath, K E; Laaksonen, S; Kutz, S J; Brooks, D R

2017-07-01

Climate oscillations and episodic processes interact with evolution, ecology and biogeography to determine the structure and complex mosaic that is the biosphere. Parasites and parasite-host assemblages are key components in a general explanatory paradigm for global biodiversity. We explore faunal assembly in the context of Quaternary time frames of the past 2.6 million years, a period dominated by episodic shifts in climate. Climate drivers cross a continuum from geological to contemporary timescales and serve to determine the structure and distribution of complex biotas. Cycles within cycles are apparent, with drivers that are layered, multifactorial and complex. These cycles influence the dynamics and duration of shifts in environmental structure on varying temporal and spatial scales. An understanding of the dynamics of high-latitude systems, the history of the Beringian nexus (the intermittent land connection linking Eurasia and North America) and downstream patterns of diversity depend on teasing apart the complexity of biotic assembly and persistence. Although climate oscillations have dominated the Quaternary, contemporary dynamics are driven by tipping points and shifting balances emerging from anthropogenic forces that are disrupting ecological structure. Climate change driven by anthropogenic forcing has supplanted a history of episodic variation and is eliminating ecological barriers and constraints on development and distribution for pathogen transmission. A framework to explore interactions of episodic processes on faunal structure and assembly is the Stockholm Paradigm, which appropriately shifts the focus from cospeciation to complexity and contingency in explanations of diversity.

Negative pressure darwinism: survival of the fittest paradigm.

PubMed

Miller, Michael; Bybordi, Farhad

2009-07-01

The use of negative pressure for wound healing has been based on a set of parameters and devices that until recently were combined into a single paradigm. Despite historical and more recent evidence providing viable alternative considerations, it is only recently that this paradigm and its tenets have come into question. As the understanding of the limits of the current paradigm and specific instances of its benefits and drawbacks are identified, shifts in the paradigm must take place if the therapy is to evolve, develop, and continue to be efficacious. The pertinence of the concept of survival of the fittest is used to explore the need for a paradigm shift in negative pressure wound therapy.

Reductionism, Paradigm Shifts, and Learning Disabilities.

ERIC Educational Resources Information Center

Forness, Steven R.

1988-01-01

In response to two papers decrying reductionism and advocating holistic constructivism in models of learning disabilities, the article applauds trends toward a shifting paradigm in the field but warns against advocating any single approach as the only valid path to effective learning. (DB)

Client-oriented Building Mass Customization (CoBMC)

NASA Astrophysics Data System (ADS)

Lee, Xia Sheng; Faris Khamidi, Mohd; Kuppusamy, Sivaraman; Tuck Heng, Chin

2017-12-01

Although much later compared to other industries including aerospace, automobile, oil and gas etc., digital technology development has been cresting towards an exponential curve in the construction industry. Technological diversity and abundance change the game from “what you can” to “what you want”. Society is changing at an unprecedented rate. Consequently adaptability will be crucial. This research paper explores the integration of digital adaptive technologies that transform the construction industry from the mass production to that of a possible client-oriented mass customization. The focus on the design, construction and performance stages of a building project, currently undergoing major overhaul faces a paradigm shift globally that will impact and compel attention for the next three decades with viable solutions such as Building Information Modelling (BIM) to manage massive data cum information. Customization maximizes clients’ participation during the design process thereby achieving greater effective value and higher satisfaction. A study between customized and standardized examples will investigate how adaptive customization will shift the design paradigm from cost to value centric. This action research will explore different aspects of emerging innovative systems already in place pushing the edge of frontiers, and transforming the building industry landscape whether micro or giga, to compliment new technologies to create an unprecedented exhilaration of freshness over the mundane, routine and mediocrity. Three identified fundamental aspects that are instrumental to Client-oriented Building Mass Customization (CoBMC) are design option visualization, parametric product information and n-dimensional modelling. The study concluded that a paradigm shift is therefore inevitable for every stakeholder including clients who will need to re-examine their roles, capabilities, and competencies in preparation towards challenging future.

Evolution in action: climate change, biodiversity dynamics and emerging infectious disease

PubMed Central

Hoberg, Eric P.; Brooks, Daniel R.

2015-01-01

Climatological variation and ecological perturbation have been pervasive drivers of faunal assembly, structure and diversification for parasites and pathogens through recurrent events of geographical and host colonization at varying spatial and temporal scales of Earth history. Episodic shifts in climate and environmental settings, in conjunction with ecological mechanisms and host switching, are often critical determinants of parasite diversification, a view counter to more than a century of coevolutionary thinking about the nature of complex host–parasite assemblages. Parasites are resource specialists with restricted host ranges, yet shifts onto relatively unrelated hosts are common during phylogenetic diversification of parasite lineages and directly observable in real time. The emerging Stockholm Paradigm resolves this paradox: Ecological Fitting (EF)—phenotypic flexibility and phylogenetic conservatism in traits related to resource use, most notably host preference—provides many opportunities for rapid host switching in changing environments, without the evolution of novel host-utilization capabilities. Host shifts via EF fuel the expansion phase of the Oscillation Hypothesis of host range and speciation and, more generally, the generation of novel combinations of interacting species within the Geographic Mosaic Theory of Coevolution. In synergy, an environmental dynamic of Taxon Pulses establishes an episodic context for host and geographical colonization. PMID:25688014

Community College Faculty: Making the Paradigm Shift.

ERIC Educational Resources Information Center

Van Ast, John

1999-01-01

Discusses the need for paradigm shifts during the next decade that address the following challenges: (1) the wider range of student ability and mastery; (2) high attrition rates; and (3) differing and often contradicting perceptions of students, faculty, and administration. Contains 180 references. (TGO)

Paradigm shifts and the development of the diagnostic and statistical manual of mental disorders: past experiences and future aspirations.

PubMed

First, Michael B

2010-11-01

Work is currently under way on the Diagnostic and Statistical Manual of Mental Disorders (DSM), Fifth Edition, due to be published by the American Psychiatric Association in 2013. Dissatisfaction with the current categorical descriptive approach has led to aspirations for a paradigm shift for DSM-5. A historical review of past revisions of the DSM was performed. Efforts undertaken before the start of the DSM-5 development process to conduct a state-of-the science review and set a research agenda were examined to determine if results supported a paradigm shift for DSM-5. Proposals to supplement DSM-5 categorical diagnosis with dimensional assessments are reviewed and critiqued. DSM revisions have alternated between paradigm shifts (the first edition of the DSM in 1952 and DSM-III in 1980) and incremental improvements (DSM-II in 1968, DSM-III-R in 1987, and DSM-IV in 1994). The results of the review of the DSM-5 research planning initiatives suggest that despite the scientific advances that have occurred since the descriptive approach was first introduced in 1980, the field lacks a sufficiently deep understanding of mental disorders to justify abandoning the descriptive approach in favour of a more etiologically based alternative. Proposals to add severity and cross-cutting dimensions throughout DSM-5 are neither paradigm shifting, given that simpler versions of such dimensions are already a component of DSM-IV, nor likely to be used by busy clinicians without evidence that they improve clinical outcomes. Despite initial aspirations that DSM would undergo a paradigm shift with this revision, DSM-5 will continue to adopt a descriptive categorical approach, albeit with a greatly expanded dimensional component.

Centralizing physician office functions. A paradigm shift.

PubMed

Croopnick, J G

1999-01-01

Recent trends show that organizations that once thought business office centralization was beneficial are re-thinking their strategies and decentralizing business office functions. This article focuses on the paradigm shift from business office centralization to decentralization and the political factors effecting this shift. It provides actual case summaries to demonstrate what has transpired, and presents an alternative strategy to establishing successful business office functions, a hybrid business office.

Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems.

PubMed

Barnosky, Anthony D; Hadly, Elizabeth A; Gonzalez, Patrick; Head, Jason; Polly, P David; Lawing, A Michelle; Eronen, Jussi T; Ackerly, David D; Alex, Ken; Biber, Eric; Blois, Jessica; Brashares, Justin; Ceballos, Gerardo; Davis, Edward; Dietl, Gregory P; Dirzo, Rodolfo; Doremus, Holly; Fortelius, Mikael; Greene, Harry W; Hellmann, Jessica; Hickler, Thomas; Jackson, Stephen T; Kemp, Melissa; Koch, Paul L; Kremen, Claire; Lindsey, Emily L; Looy, Cindy; Marshall, Charles R; Mendenhall, Chase; Mulch, Andreas; Mychajliw, Alexis M; Nowak, Carsten; Ramakrishnan, Uma; Schnitzler, Jan; Das Shrestha, Kashish; Solari, Katherine; Stegner, Lynn; Stegner, M Allison; Stenseth, Nils Chr; Wake, Marvalee H; Zhang, Zhibin

2017-02-10

Conservation of species and ecosystems is increasingly difficult because anthropogenic impacts are pervasive and accelerating. Under this rapid global change, maximizing conservation success requires a paradigm shift from maintaining ecosystems in idealized past states toward facilitating their adaptive and functional capacities, even as species ebb and flow individually. Developing effective strategies under this new paradigm will require deeper understanding of the long-term dynamics that govern ecosystem persistence and reconciliation of conflicts among approaches to conserving historical versus novel ecosystems. Integrating emerging information from conservation biology, paleobiology, and the Earth sciences is an important step forward on the path to success. Maintaining nature in all its aspects will also entail immediately addressing the overarching threats of growing human population, overconsumption, pollution, and climate change. Copyright © 2017, American Association for the Advancement of Science.

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation.

PubMed

Girnita, Leonard; Worrall, Claire; Takahashi, Shin-Ichiro; Seregard, Stefan; Girnita, Ada

2014-07-01

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and progression of cancer; however, therapeutics targeting it have had disappointing results in the clinic. As a receptor tyrosine kinase (RTK), IGF-1R is traditionally described as an ON/OFF system, with ligand stabilizing the ON state and exclusive kinase-dependent signaling activation. Newly added to the traditional model, ubiquitin-mediated receptor downregulation and degradation was originally described as a response to ligand/receptor interaction and thus inseparable from kinase signaling activation. Yet, the classical model has proven over-simplified and insufficient to explain experimental evidence accumulated over the last decade, including kinase-independent signaling, unbalanced signaling, or dissociation between signaling and receptor downregulation. Based on the recent findings that IGF-1R "borrows" components of G-protein coupled receptor (GPCR) signaling, including β-arrestins and G-protein-related kinases, we discuss the emerging paradigm for the IGF-1R as a functional RTK/GPCR hybrid, which integrates the kinase signaling with the IGF-1R canonical GPCR characteristics. The contradictions to the classical IGF-1R signaling concept as well as the design of anti-IGF-1R therapeutics treatment are considered in the light of this paradigm shift and we advocate recognition of IGF-1R as a valid target for cancer treatment.

Highlighting in Early Childhood: Learning Biases Through Attentional Shifting.

PubMed

Burling, Joseph M; Yoshida, Hanako

2017-02-01

The literature on human and animal learning suggests that individuals attend to and act on cues differently based on the order in which they were learned. Recent studies have proposed that one specific type of learning outcome, the highlighting effect, can serve as a framework for understanding a number of early cognitive milestones. However, little is known how this learning effect itself emerges among children, whose memory and attention are much more limited compared to adults. Two experiments were conducted using different versions of the general highlighting paradigm: Experiment 1 tested 3 to 6 year olds with a newly developed image-based version of the paradigm, which was designed specifically to test young children. Experiment 2 tested the validity of an image-based implementation of the highlighting paradigm with adult participants. The results from Experiment 1 provide evidence for the highlighting effect among children 3-6 years old, and they suggest age-related differences in dividing attention among multiple cues during learning. Experiment 2 replicated results from previous studies by showing robust biases for both image-based and text-based versions of the highlighting task. This study suggests that sensitivity to learning order emerges early through the process of cued attention, and the role of the highlighting effect in early language learning is discussed. Copyright © 2016 Cognitive Science Society, Inc.

Activity Theory and the Transformation of Pedagogic Practice

ERIC Educational Resources Information Center

Yamazumi, Katsuhiro

2006-01-01

Today, work and other societal practices are experiencing accelerating paradigm shifts from mass-production-based systems toward new systems based on networking between organizations, collaboration, and partnerships. This shift requires new paradigms in the fields of education, learning, and development. As human activity quickly changes to…

What Philanthropy's Paradigm Shift Means for Higher Ed Fundraising

ERIC Educational Resources Information Center

McCully, George

2015-01-01

This is an unprecedented era of human history, in which simultaneous transformations of every technically advanced field are being driven by the powerful technological revolution in information and communications. Technically, these transformative changes are "paradigm shifts"--a distinct kind of historical change in which the governing…

Centrality and Flow Vergence gradient based Path analysis of scientific literature: A case study of Biotechnology for Engineering

NASA Astrophysics Data System (ADS)

Lathabai, Hiran H.; Prabhakaran, Thara; Changat, Manoj

2015-07-01

Biotechnology, ever since its inception has had a huge impact on the society and its various applications have been intricately woven into the human web of life. Its evolution amidst all the other research realms vital to mankind is remarkable. In this paper, we intend to identify the radical innovations in Biotechnology for Engineering using network analyses. Centrality analysis and Path analysis are used for identifying important works. Existence of Flow Vergence effect in the scientific literature is revealed. Flow Vergence gradient, an arc metric derived from FV model, is utilised for Path analysis which detects pivotal papers of paradigm shift more accurately. A major paradigm shift has been identified in the business models of Biotechnology for Engineering - 'Capability to Connectivity' model. Evidence towards the adoption of business practices in BT firms by nanotechnology start-ups is also identified. The notion of critical divergence is introduced and the exhibition of interdisciplinary interaction in emerging fields due to critical divergence is discussed. Implications of above analyses which target: (i) Science and technology policy makers, (ii) industrialists and investors, (iii) researchers in academia as well as industry, are also discussed.

Spatial Heterogeneity, Scale, Data Character and Sustainable Transport in the Big Data Era

NASA Astrophysics Data System (ADS)

Jiang, Bin

2018-04-01

In light of the emergence of big data, I have advocated and argued for a paradigm shift from Tobler's law to scaling law, from Euclidean geometry to fractal geometry, from Gaussian statistics to Paretian statistics, and - more importantly - from Descartes' mechanistic thinking to Alexander's organic thinking. Fractal geometry falls under the third definition of fractal - that is, a set or pattern is fractal if the scaling of far more small things than large ones recurs multiple times (Jiang and Yin 2014) - rather than under the second definition of fractal, which requires a power law between scales and details (Mandelbrot 1982). The new fractal geometry is more towards living geometry that "follows the rules, constraints, and contingent conditions that are, inevitably, encountered in the real world" (Alexander et al. 2012, p. 395), not only for understanding complexity, but also for creating complex or living structure (Alexander 2002-2005). This editorial attempts to clarify why the paradigm shift is essential and to elaborate on several concepts, including spatial heterogeneity (scaling law), scale (or the fourth meaning of scale), data character (in contrast to data quality), and sustainable transport in the big data era.

The interface between forensic science and technology: how technology could cause a paradigm shift in the role of forensic institutes in the criminal justice system

PubMed Central

Kloosterman, Ate; Mapes, Anna; Geradts, Zeno; van Eijk, Erwin; Koper, Carola; van den Berg, Jorrit; Verheij, Saskia; van der Steen, Marcel; van Asten, Arian

2015-01-01

In this paper, the importance of modern technology in forensic investigations is discussed. Recent technological developments are creating new possibilities to perform robust scientific measurements and studies outside the controlled laboratory environment. The benefits of real-time, on-site forensic investigations are manifold and such technology has the potential to strongly increase the speed and efficacy of the criminal justice system. However, such benefits are only realized when quality can be guaranteed at all times and findings can be used as forensic evidence in court. At the Netherlands Forensic Institute, innovation efforts are currently undertaken to develop integrated forensic platform solutions that allow for the forensic investigation of human biological traces, the chemical identification of illicit drugs and the study of large amounts of digital evidence. These platforms enable field investigations, yield robust and validated evidence and allow for forensic intelligence and targeted use of expert capacity at the forensic institutes. This technological revolution in forensic science could ultimately lead to a paradigm shift in which a new role of the forensic expert emerges as developer and custodian of integrated forensic platforms. PMID:26101289

Applying technology to visually support language and communication in individuals with autism spectrum disorders.

PubMed

Shane, Howard C; Laubscher, Emily H; Schlosser, Ralf W; Flynn, Suzanne; Sorce, James F; Abramson, Jennifer

2012-06-01

The burgeoning role of technology in society has provided opportunities for the development of new means of communication for individuals with Autism Spectrum Disorders (ASD). This paper offers an organizational framework for describing traditional and emerging augmentative and alternative communication (AAC) technology, and highlights how tools within this framework can support a visual approach to everyday communication and improve language instruction. The growing adoption of handheld media devices along with applications acquired via a consumer-oriented delivery model suggests a potential paradigm shift in AAC for people with ASD.

Partnerships between Professional and Amateur Astronomers: A Shift in Research Paradigm

NASA Astrophysics Data System (ADS)

Yanamandra-Fisher, Padma A.; Orton, G. S.; Casquinha, P.; Coffelt, A.; Delcroix, M.; Go, C.; Hueso, R.; Jaeschke, W.; Kardasis, M.; Kraaikamp, E.; Morales, E.; Peach, D.; Rogers, J.; Wesley, A.; Willems, F.; Wilson, T.

2012-10-01

"Citizen Astronomy" can be thought of as the paradigm shift transforming the nature of observational astronomy. The night sky, with all its delights and mysteries, enthralls professional and amateur astronomers, and students who will form the next generation of scientists and engineers. These students are matriculating in an era of reduced funding for core competencies such as science, technology, mathematics and engineering (STEM) sciences and an ongoing general decline in these sciences. How then do we re-generate their interest and engage students while we perform cutting-edge planetary science in a fiscally constrained environment? One promising solution is to promote the emerging partnerships between professional and dedicated proficient amateur astronomers, that rely on creating a niche for long timeline of multispectral remote sensing. In the past decade, it is the collective observations and their analyses by the ever-increasing global network of amateur astronomers that has discovered interesting phenomena and provided the reference backdrop for observations by professional ground-based professional astronomers and spacecraft missions. We shall focus on our collaboration or "Citizen Astronomy: Jupiter and Saturn" for the past five years and illustrate the strong synergy between the two groups that has produced new scientific results. With the active inclusion and use of emerging social media (Facebook, Twitter, etc.), the near daily communication and updates (via email, Skype, Facebook) between the two groups is becoming a powerful tool for ground-based remote sensing. However, what is sorely lacking in this paradigm is the inclusion of teachers and students and, therefore, its inclusion in the secondary and tertiary classrooms. We will provide various scenarios to address this issue, and emphasize the various aspects of STEM learning/teaching that is necessary for students and teachers - all that can be performed at low cost; and showcase some of our contributors and current science investigations.

Il Fasciculo di Medicina of 1493: medical culture through the eyes of the artist.

PubMed

DiMaio, Salvatore; Discepola, Federico; Del Maestro, Rolando F

2006-01-01

THE FASCICULUS MEDICINA, printed in 1491, is considered the first illustrated medical book. The Latin essays and illustrations in this volume provide insight into the medical knowledge of Western Europe and, in the Italian edition published in 1493, glimpses into the medical culture of the late 15th century. We outline the scientific and social environments into which the Fasciculus Medicinae of 1491 was introduced and the transition that occurred with the publication of the 1493 Italian edition. The artist of the 1493 Fasciculo witnessed a paradigm shift occurring. In four woodcuts, the artist captured four themes: the relevance of knowledge-based medicine, the emergence of laboratory medicine, the Hippocratic lessons of patient observation, and the emerging revolution in anatomy.

Introducing Therioepistemology: the study of how knowledge is gained from animal research.

PubMed

Garner, Joseph P; Gaskill, Brianna N; Weber, Elin M; Ahloy-Dallaire, Jamie; Pritchett-Corning, Kathleen R

2017-03-22

This focus issue of Lab Animal coincides with a tipping point in biomedical research. For the first time, the scale of the reproducibility and translatability crisis is widely understood beyond the small cadre of researchers who have been studying it and the pharmaceutical and biotech companies who have been living it. Here we argue that an emerging literature, including the papers in this focus issue, has begun to congeal around a set of recurring themes, which themselves represent a paradigm shift. This paradigm shift can be characterized at the micro level as a shift from asking "what have we controlled for in this model?" to asking "what have we chosen to ignore in this model, and at what cost?" At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study. We feel that we are witnessing the birth of a new discipline, which we term Therioepistemology, or the study of how knowledge is gained from animal research. In this paper, we outline six questions that serve as a heuristic for critically evaluating animal-based biomedical research from a therioepistemological perspective. These six questions sketch out the broad reaches of this new discipline, though they may change or be added to as this field evolves. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health and animal well-being.

Embracing the Cloud: Six Ways to Look at the Shift to Cloud Computing

ERIC Educational Resources Information Center

Ullman, David F.; Haggerty, Blake

2010-01-01

Cloud computing is the latest paradigm shift for the delivery of IT services. Where previous paradigms (centralized, decentralized, distributed) were based on fairly straightforward approaches to technology and its management, cloud computing is radical in comparison. The literature on cloud computing, however, suffers from many divergent…

A Paradigm Shift toward Evidence-Based Clinical Practice: Developing a Performance Assessment

ERIC Educational Resources Information Center

Wentworth, Nancy; Erickson, Lynnette B.; Lawrence, Barbara; Popham, J. Aaron; Korth, Byran

2009-01-01

The Clinical Practice Assessment System (CPAS), developed in response to teacher preparation program accreditation requirements, represents a paradigm shift of one university toward data-based decision-making in teacher education programs. The new assessment system is a scale aligned with INTASC Standards, which allows for observation and…

Has the Education Paradigm Begun to Shift?

ERIC Educational Resources Information Center

Chadwick, Clifton B.

2014-01-01

The author reviews various elements of what may be considered as evidence that the long-awaited shift in the education paradigm is actually happening. Concepts like student-centered learning, attainment-based evaluation, knowledge-based constructivism, and effort-based intelligence are growing, are being more widely recognized as important, and…

Changing environments or shifting paradigms? Strategic decision making toward water protection in Helsinki, 1850-2000.

PubMed

Laakkonen, Simo; Laurila, Sari

2007-04-01

The study examines the history of strategic decision-making concerning water protection in Helsinki, 1850-2000. We identified five major strategic decisions that occurred during the study period. The results indicate that strategic decision-making evolves in long-term policy cycles that last on average 20-30 years. New policy cycles are caused by paradigm shifts. Paradigms are shared and predominant ways of understanding reality that help when groups must act to solve common and complex environmental problems. However the internal structure and external dynamics of paradigms are contradictory. Although paradigms serve initially as means to redefine problems and find creative solutions, as time goes by each paradigm seems to become also a barrier that restricts the introduction of new ways of thinking and acting. The power of paradigms lies in the fact that they can be defined as scientific but also social, political, or cultural agreements depending on the context.

The search for understanding: the role of paradigms.

PubMed

Kelly, Marcella; Dowling, Maura; Millar, Michelle

2018-03-16

Kuhn's ( 1962 ) acknowledgement of a paradigm as a way that scientists make sense of their world and its reality gave recognition to the idea of 'paradigm shift'. This shift exposes the transience of paradigm development shaped by societal and scientific evolution. This ongoing evolutionary development provides the researcher with many paradigms to consider regarding how research is undertaken and the search for understanding achieved. An understanding of paradigm development is necessary when planning a study and can shape the search for understanding. It is hoped that the discussion presented here will assist novice and experienced researchers in articulating the rationales for their paradigm choices. An overview of the dominant paradigms is presented, reflecting ongoing paradigm development shaped by ontological, epistemological and methodological perspectives. Potential paradigm choices that shape research aims, objectives and focus in the search for understanding are considered. The inherent debates about paradigm shift, division, war and synthesis leave the researcher many perspectives to consider. Articulating the world views underpinning constructivism, interpretivism and pragmatism is particularly challenging because of the blurring of boundaries between them. The evolutionary nature of paradigmatic development has provided nurse researchers with the opportunity for methodological openness to the myriad research approaches, methods and designs that they may choose to answer their research question. However, it is imperative that researchers consider their ontological stances and the nature of their research questions. This is challenging in constructivism, interpretivism and pragmatism, where there is often an overlap of paradigm world views. ©2018 RCN Publishing Company Ltd. All rights reserved. Not to be copied, transmitted or recorded in any way, in whole or part, without prior permission of the publishers.

Nature: a new paradigm for well-being and ergonomics.

PubMed

Richardson, Miles; Maspero, Marta; Golightly, David; Sheffield, David; Staples, Vicki; Lumber, Ryan

2017-02-01

Nature is presented as a new paradigm for ergonomics. As a discipline concerned with well-being, the importance of natural environments for wellness should be part of ergonomics knowledge and practice. This position is supported by providing a concise summary of the evidence of the value of the natural environment to well-being. Further, an emerging body of research has found relationships between well-being and a connection to nature, a concept that reveals the integrative character of human experience which can inform wider practice and epistemology in ergonomics. Practitioners are encouraged to bring nature into the workplace, so that ergonomics keeps pace with the move to nature-based solutions, but also as a necessity in the current ecological and social context. Practitioner Summary: Nature-based solutions are coming to the fore to address societal challenges such as well-being. As ergonomics is concerned with well-being, there is a need for a paradigm shift in the discipline. This position is supported by providing a concise summary of the evidence of the value of the natural environment to well-being.

A Paradigm Shift for Educational Administrators: The Total Quality Movement.

ERIC Educational Resources Information Center

Hough, M. J.

This paper reviews the major ideas of the seminal total quality management theorists, such as Deming, Crosby, Juran, Ishikawa, and Imai, to illustrate how total quality management is applicable to education. It is argued that there is a need for a paradigm shift in educational administration. The first part reviews current Australian societal…

Research Paradigm Shifts and Their Bibliographic Consequences for English Composition Researchers.

ERIC Educational Resources Information Center

Scott, Patrick

There are four problems in modern composition bibliography that result directly from the continuing research paradigm instability in the field. The first problem is that of definition. Composition is a hybrid, practical sort of field, with very ill-defined and shifting boundaries. The recent extension of composition from "formal writing…

Developing Competency-Based Advising Practices in Response to Paradigm Shifts in Higher Education

ERIC Educational Resources Information Center

Walters, Giovanna

2016-01-01

Competency-based programs have gained prominence in recent years for two primary reasons. First, more students are seeking ways to apply nonclassroom learning experiences toward a degree. Second, a paradigm shift in higher education encourages postsecondary curriculum developers to accept nonclassroom experiences as demonstrations of skills and…

Epistasis-list.org: A Curated Database of Gene-Gene and Gene-Environment Interactions in Human Epidemiology

EPA Science Inventory

The field of human genetics has experienced a paradigm shift in that common diseases are now thought to be due to the complex interactions among numerous genetic and environmental factors. This paradigm shift has prompted the development of myriad novel methods to detect such int...

Responding to Global Shifts: Meta-Practice as a Relevant Social Work Practice Paradigm

ERIC Educational Resources Information Center

Grise-Owens, Erlene; Miller, J. Jay; Owens, Larry W.

2014-01-01

In response to increasing global changes, this article proposes that social work education add meta-practice to traditional micro-, mezzo-, and macro-practice curriculum areas. Drawing on pertinent literature, the authors conceptualize meta-practice as a necessary paradigm shift for competent and relevant social work practice. Further, the authors…

Deconstructing Discourses about "New 'Paradigms' of Teaching": A Foucaultian and Wittgensteinian Perspective

ERIC Educational Resources Information Center

Stickney, Jeff

2006-01-01

Offering a cautionary tale about the abuses of paradigm-shift rhetoric in secondary school reforms, the paper shows potential misuses and ethical effects of the relativistic language-game in post-compulsory education. Those initiating the shift often shelter their reform from the criticism of non-adepts, marginalizing expert teachers that adhere…

The Paradigm Shift: Leadership Challenges in the Public Sector Schools in Pakistan

ERIC Educational Resources Information Center

Mansoor, Zahida

2015-01-01

Previous research has established that school heads as leaders are vital to the successful implementation of educational reforms (Derek, 2009; Robinson, Lloyd, & Rowe, 2008). Education system in Pakistan is going through a paradigm shift from teacher centered to learner centered classrooms using English as the instructional language. The…

Evolution of psychology and counseling in infertility.

PubMed

Boivin, Jacky; Gameiro, Sofia

2015-08-01

Five key paradigm shifts are described to illustrate the evolution of psychology and counseling in infertility. The first paradigm shift was in the 1930s when psychosomatic concepts were introduced in obstetrics and gynecology as causal factors to explain why some couples could not conceive despite the absence of organic pathology. In the second shift, the nurse advocacy movement of the 1970s stimulated the investigation of the psychosocial consequences of infertility and promoted counseling to help couples grieve childlessness when medical treatments often could not help them conceive. The third shift occurred with the advent of IVF, which created a demand for mental health professionals in fertility clinics. Mental health professionals assessed the ability of couples to withstand the demands of this new high technology treatment as well as their suitability as potential parents. The fourth shift, in the 1990s, saw reproductive medicine embrace the principles of evidence-based medicine, which introduced a much more rigorous approach to medical practice (effectiveness and safety) that extended to psychosocial interventions. The most recent paradigm shift, in the new millennium, occurred with the realization that compliance with protracted fertility treatment depended on the adoption of an integrated approach to fertility care. An integrated approach could reduce treatment burden arising from multiple sources (i.e., patient, clinic, and treatment). This review describes these paradigm shifts and reflects on future clinical and research directions for mental health professionals. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Food for Thought …

PubMed Central

Smirnova, Lena; Hogberg, Helena T.; Leist, Marcel; Hartung, Thomas

2016-01-01

Summary In recent years neurodevelopmental problems in children have increased at a rate that suggests lifestyle factors and chemical exposures as likely contributors. When environmental chemicals contribute to neurodevelopmental disorders developmental neurotoxicity (DNT) becomes an enormous concern. But how can it be tackled? Current animal test-based guidelines are prohibitively expensive, at $1.4 million per substance, while their predictivity for human health effects may be limited, and mechanistic data that would help species extrapolation are not available. A broader screening for substances of concern requires a reliable testing strategy, applicable to larger numbers of substances, and sufficiently predictive to warrant further testing. This review discusses the evidence for possible contributions of environmental chemicals to DNT, limitations of the current test paradigm, emerging concepts and technologies pertinent to in vitro DNT testing and assay evaluation, as well as the prospect of a paradigm shift based on 21st century technologies. PMID:24687333

SWOT analysis on National Common Geospatial Information Service Platform of China

NASA Astrophysics Data System (ADS)

Zheng, Xinyan; He, Biao

2010-11-01

Currently, the trend of International Surveying and Mapping is shifting from map production to integrated service of geospatial information, such as GOS of U.S. etc. Under this circumstance, the Surveying and Mapping of China is inevitably shifting from 4D product service to NCGISPC (National Common Geospatial Information Service Platform of China)-centered service. Although State Bureau of Surveying and Mapping of China has already provided a great quantity of geospatial information service to various lines of business, such as emergency and disaster management, transportation, water resource, agriculture etc. The shortcomings of the traditional service mode are more and more obvious, due to the highly emerging requirement of e-government construction, the remarkable development of IT technology and emerging online geospatial service demands of various lines of business. NCGISPC, which aimed to provide multiple authoritative online one-stop geospatial information service and API for further development to government, business and public, is now the strategic core of SBSM (State Bureau of Surveying and Mapping of China). This paper focuses on the paradigm shift that NCGISPC brings up by using SWOT (Strength, Weakness, Opportunity and Threat) analysis, compared to the service mode that based on 4D product. Though NCGISPC is still at its early stage, it represents the future service mode of geospatial information of China, and surely will have great impact not only on the construction of digital China, but also on the way that everyone uses geospatial information service.

Evolution in action: climate change, biodiversity dynamics and emerging infectious disease.

PubMed

Hoberg, Eric P; Brooks, Daniel R

2015-04-05

Climatological variation and ecological perturbation have been pervasive drivers of faunal assembly, structure and diversification for parasites and pathogens through recurrent events of geographical and host colonization at varying spatial and temporal scales of Earth history. Episodic shifts in climate and environmental settings, in conjunction with ecological mechanisms and host switching, are often critical determinants of parasite diversification, a view counter to more than a century of coevolutionary thinking about the nature of complex host-parasite assemblages. Parasites are resource specialists with restricted host ranges, yet shifts onto relatively unrelated hosts are common during phylogenetic diversification of parasite lineages and directly observable in real time. The emerging Stockholm Paradigm resolves this paradox: Ecological Fitting (EF)--phenotypic flexibility and phylogenetic conservatism in traits related to resource use, most notably host preference--provides many opportunities for rapid host switching in changing environments, without the evolution of novel host-utilization capabilities. Host shifts via EF fuel the expansion phase of the Oscillation Hypothesis of host range and speciation and, more generally, the generation of novel combinations of interacting species within the Geographic Mosaic Theory of Coevolution. In synergy, an environmental dynamic of Taxon Pulses establishes an episodic context for host and geographical colonization. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Caring for patients with kidney disease: shifting the paradigm from evidence-based medicine to patient-centered care.

PubMed

O'Hare, Ann M; Rodriguez, Rudolph A; Bowling, Christopher Barrett

2016-03-01

The last several decades have witnessed the emergence of evidence-based medicine as the dominant paradigm for medical teaching, research and practice. Under an evidence-based approach, populations rather than individuals become the primary focus of investigation. Treatment priorities are largely shaped by the availability, relevance and quality of evidence and study outcomes and results are assumed to have more or less universal significance based on their implications at the population level. However, population-level treatment goals do not always align with what matters the most to individual patients-who may weigh the risks, benefits and harms of recommended treatments quite differently. In this article we describe the rise of evidence-based medicine in historical context. We discuss limitations of this approach for supporting real-world treatment decisions-especially in older adults with confluent comorbidity, functional impairment and/or limited life expectancy-and we describe the emergence of more patient-centered paradigms to address these limitations. We explain how the principles of evidence-based medicine have helped to shape contemporary approaches to defining, classifying and managing patients with chronic kidney disease. We discuss the limitations of this approach and the potential value of a more patient-centered paradigm, with a particular focus on the care of older adults with this condition. We conclude by outlining ways in which the evidence-base might be reconfigured to better support real-world treatment decisions in individual patients and summarize relevant ongoing initiatives. Published by Oxford University Press on behalf of ERA-EDTA 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Solar Ethics: A New Paradigm for Environmental Ethics and Education?

ERIC Educational Resources Information Center

Peters, Michael A.; Hung, Ruyu

2009-01-01

This article provides grounds for a new paradigm of environmental ethics and education based on the centrality of the sun and solar system--a shift from anthropocentrism to solar systemism. The article provides some grounds for this shift from the physical sciences that considers the planet Earth as part of a wider system that is dependent upon…

Sustainability or Limitless Expansion: Paradigm Shift in HRD Practice and Teaching

ERIC Educational Resources Information Center

Ardichvili, Alexandre

2012-01-01

Purpose: This paper aims to discuss a shift from the mentality of limitless growth and expansion to the new sustainability paradigm in HRD practice, and identifies what corresponding changes are needed in human resource development (HRD) university programs. Design/methodology/approach: The paper is based on a review of the literature in HRD and…

Multimission Software Reuse in an Environment of Large Paradigm Shifts

NASA Technical Reports Server (NTRS)

Wilson, Robert K.

1996-01-01

The ground data systems provided for NASA space mission support are discussed. As space missions expand, the ground systems requirements become more complex. Current ground data systems provide for telemetry, command, and uplink and downlink processing capabilities. The new millennium project (NMP) technology testbed for 21st century NASA missions is discussed. The program demonstrates spacecraft and ground system technologies. The paradigm shift from detailed ground sequencing to a goal oriented planning approach is considered. The work carried out to meet this paradigm for the Deep Space-1 (DS-1) mission is outlined.

The Underlying Social Dynamics of Paradigm Shifts.

PubMed

Rodriguez-Sickert, Carlos; Cosmelli, Diego; Claro, Francisco; Fuentes, Miguel Angel

2015-01-01

We develop here a multi-agent model of the creation of knowledge (scientific progress or technological evolution) within a community of researchers devoted to such endeavors. In the proposed model, agents learn in a physical-technological landscape, and weight is attached to both individual search and social influence. We find that the combination of these two forces together with random experimentation can account for both i) marginal change, that is, periods of normal science or refinements on the performance of a given technology (and in which the community stays in the neighborhood of the current paradigm); and ii) radical change, which takes the form of scientific paradigm shifts (or discontinuities in the structure of performance of a technology) that is observed as a swift migration of the knowledge community towards the new and superior paradigm. The efficiency of the search process is heavily dependent on the weight that agents posit on social influence. The occurrence of a paradigm shift becomes more likely when each member of the community attaches a small but positive weight to the experience of his/her peers. For this parameter region, nevertheless, a conservative force is exerted by the representatives of the current paradigm. However, social influence is not strong enough to seriously hamper individual discovery, and can act so as to empower successful individual pioneers who have conquered the new and superior paradigm.

The Underlying Social Dynamics of Paradigm Shifts

PubMed Central

Claro, Francisco; Fuentes, Miguel Angel

2015-01-01

We develop here a multi-agent model of the creation of knowledge (scientific progress or technological evolution) within a community of researchers devoted to such endeavors. In the proposed model, agents learn in a physical-technological landscape, and weight is attached to both individual search and social influence. We find that the combination of these two forces together with random experimentation can account for both i) marginal change, that is, periods of normal science or refinements on the performance of a given technology (and in which the community stays in the neighborhood of the current paradigm); and ii) radical change, which takes the form of scientific paradigm shifts (or discontinuities in the structure of performance of a technology) that is observed as a swift migration of the knowledge community towards the new and superior paradigm. The efficiency of the search process is heavily dependent on the weight that agents posit on social influence. The occurrence of a paradigm shift becomes more likely when each member of the community attaches a small but positive weight to the experience of his/her peers. For this parameter region, nevertheless, a conservative force is exerted by the representatives of the current paradigm. However, social influence is not strong enough to seriously hamper individual discovery, and can act so as to empower successful individual pioneers who have conquered the new and superior paradigm. PMID:26418255

Experience-based consulting: the value proposition.

PubMed

Pliner, Nicole; Thrall, James; Boland, Giles; Palumbo, Denise

2004-11-01

Consulting is a profession universally accepted and well entrenched throughout the business world. Whether it is providing objective analysis, supplying a specific expertise, managing a project, or simply adding extra manpower, consultants can add value. However, what are the attributes of a good consultant? In health care, with the rapid pace of emerging technologies, economic intricacies, and the complexities of clinical care, hands-on experience is the key. Recognizing the power of consultants with hands-on experience, the Department of Radiology at Massachusetts General Hospital launched the Radiology Consulting Group, an "experience-based" model for consulting that may potentially shift the profession's paradigm.

A South African Perspective on Entrepreneurship and Business Creation, and its Links to Research Exploitation

NASA Astrophysics Data System (ADS)

Comins, N. R.

Transition from the Industrial to the Information Age is creating a paradigm shift for business, education, and research and development. The entrenched culture of corporate R&D groups in developed countries is increasingly complemented by innovative and nimble small and medium high-tech enterprises, dramatically changing many economies. Entrepreneurial trends amongst research students, able to exploit modern information technology for networking, collaboration and business, are increasing. South Africa has emerged into this global economy without these trends being well established. This paper will describe and contrast developments and detail initiatives such as The Innovation Hub.

Targeted Therapies in NSCLC: Emerging oncogene targets following the success of EGFR

PubMed Central

Berge, Eamon M; Doebele, Robert C

2014-01-01

The diagnostic testing, treatment and prognosis of non-small cell lung cancer (NSCLC) has undergone a paradigm shift since the discovery of sensitizing mutations in the epidermal growth factor receptor (EGFR) gene in a subset of NSCLC patients. Several additional oncogenic mutations, including gene fusions and amplifications have since been discovered, with a number of drugs that target each specific oncogene. This review focuses on oncogenes in NSCLC other than EGFR and their companion ‘targeted therapies’. Particular emphasis is placed on the role of ALK, ROS1, RET, MET, BRAF, and HER2 in NSCLC. PMID:24565585

Emotion and decision making.

PubMed

Lerner, Jennifer S; Li, Ye; Valdesolo, Piercarlo; Kassam, Karim S

2015-01-03

A revolution in the science of emotion has emerged in recent decades, with the potential to create a paradigm shift in decision theories. The research reveals that emotions constitute potent, pervasive, predictable, sometimes harmful and sometimes beneficial drivers of decision making. Across different domains, important regularities appear in the mechanisms through which emotions influence judgments and choices. We organize and analyze what has been learned from the past 35 years of work on emotion and decision making. In so doing, we propose the emotion-imbued choice model, which accounts for inputs from traditional rational choice theory and from newer emotion research, synthesizing scientific models.

Calciphylaxis: no longer rare; no longer calciphylaxis? A paradigm shift for wound, ostomy and continence nursing.

PubMed

Feeser, Dianne L

2011-01-01

This article challenges conventional wisdom that calciphylaxis is a rare condition. Rather, emerging evidence suggests that calciphylaxis is neither rare nor uncommon. In addition, the term calciphylaxis is questioned because misrepresents the underlying etiology of the condition. Multiple researchers and clinicians advocate abandoning the use of the term, but nursing literature has not yet followed suit. This article reviews the epidemiology, clinical manifestations, diagnosis, prevention, and treatment of this condition and associated wounds, and suggests areas for future research. The WOC nurse's role as an educator, leader, researcher, clinical expert, and patient advocate is summarized.

Transoral laser surgery for laryngeal carcinoma: has Steiner achieved a genuine paradigm shift in oncological surgery?

PubMed

Harris, A T; Tanyi, A; Hart, R D; Trites, J; Rigby, M H; Lancaster, J; Nicolaides, A; Taylor, S M

2018-01-01

Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO 2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predominantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase 'paradigm shift' in his groundbreaking book The Structure of Scientific Revolutions. He argued that the arrival of the new and often incompatible idea forms the core of a new paradigm, the birth of an entirely new way of thinking. This article discusses whether Steiner and colleagues truly brought about a paradigm shift in oncological surgery. By rejecting the principle of en block resection and by replacing it with the belief that not only is it oncologically safe to cut through the substance of the tumour but in doing so one can actually achieve better results, Steiner was able to truly revolutionise the management of laryngeal cancer. Even though within this article the repercussions of his insight are limited to the upper aerodigestive tract oncological surgery, his willingness to question other peoples' dogma makes his contribution truly a genuine paradigm shift.

Facilitating climate-change-induced range shifts across continental land-use barriers.

PubMed

Robillard, Cassandra M; Coristine, Laura E; Soares, Rosana N; Kerr, Jeremy T

2015-12-01

Climate changes impose requirements for many species to shift their ranges to remain within environmentally tolerable areas, but near-continuous regions of intense human land use stretching across continental extents diminish dispersal prospects for many species. We reviewed the impact of habitat loss and fragmentation on species' abilities to track changing climates and existing plans to facilitate species dispersal in response to climate change through regions of intensive land uses, drawing on examples from North America and elsewhere. We identified an emerging analytical framework that accounts for variation in species' dispersal capacities relative to both the pace of climate change and habitat availability. Habitat loss and fragmentation hinder climate change tracking, particularly for specialists, by impeding both propagule dispersal and population growth. This framework can be used to identify prospective modern-era climatic refugia, where the pace of climate change has been slower than surrounding areas, that are defined relative to individual species' needs. The framework also underscores the importance of identifying and managing dispersal pathways or corridors through semi-continental land use barriers that can benefit many species simultaneously. These emerging strategies to facilitate range shifts must account for uncertainties around population adaptation to local environmental conditions. Accounting for uncertainties in climate change and dispersal capabilities among species and expanding biological monitoring programs within an adaptive management paradigm are vital strategies that will improve species' capacities to track rapidly shifting climatic conditions across landscapes dominated by intensive human land use. © 2015 Society for Conservation Biology.

Organizational Paradigm Shifts.

ERIC Educational Resources Information Center

National Association of College and University Business Officers, Washington, DC.

This collection of essays explores a new paradigm of higher education. The first essay, "Beyond Re-engineering: Changing the Organizational Paradigm" (L. Edwin Coate), suggests a model of quality process management and a structure for managing organizational change. "Thinking About Consortia" (Mary Jo Maydew) discusses…

The New Rule Paradigm Shift: Transforming At-Risk Programs by Matching Business Archetypes Strategies in the Global Market

ERIC Educational Resources Information Center

Stark, Paul S.

2007-01-01

The challenge was given to transform aviation-related programs to keep them from being eliminated. These programs were to be discontinued due to enrollment declines, costs, legislative mandates, lack of administrative support, and drastic state budget reductions. The New Rule was a paradigm shift of focus to the global market for program…

Utilizing Critical Race Theory to Examine Race/Ethnicity, Racism, and Power in Student Development Theory and Research

ERIC Educational Resources Information Center

Hernández, Ebelia

2016-01-01

Recognition of social forces (racism, privilege, power) to the extent that is required by critical race theory (CRT) results in a paradigm shift in the way that we theorize and research student development, specifically self-authorship. This paradigm shift moves the center of analysis from individual, to the individual in relation to her…

Mechanisms of Deficit of Visuospatial Attention Shift in Children with Developmental Coordination Disorder: A Neurophysiological Measure of the Endogenous Posner Paradigm

ERIC Educational Resources Information Center

Tsai, Chia-Liang; Pan, Chien-Yu; Cherng, Rong-Ju; Hsu, Ya-Wen; Chiu, Hsing-Hui

2009-01-01

The purpose of this study was to investigate and compare the mechanisms of brain activity, as revealed by a combination of the visuospatial attention shifting paradigm and event-related potentials (ERP) in children with developmental coordination disorder (DCD) and typically developing children. Twenty-eight DCD children and 26 typically…

Why a Paradigm Shift of "More than Human Ontologies" Is Needed: Putting to Work Poststructural and Posthuman Theories in Writers' Studio

ERIC Educational Resources Information Center

Kuby, Candace R.

2017-01-01

This manuscript puts to work "more than human ontologies" drawing on poststructural (rhizomatic) and posthumanist (intra-active) theories by plugging-in concepts with data produced in a second grade Writers' Studio to illustrate why a paradigm shift of "more than human ontologies" is needed. Specifically, how ways of…

Paradigm shift in bacteriophage-mediated delivery of anticancer drugs: from targeted 'magic bullets' to self-navigated 'magic missiles'.

PubMed

Petrenko, Valery A; Gillespie, James W

2017-03-01

New phage-directed nanomedicines have emerged recently as a result of the in-depth study of the genetics and structure of filamentous phage and evolution of phage display and phage nanobiotechnology. This review focuses on the progress made in the development of the cancer-targeted nanomaterials and discusses the trends in using phage as a bioselectable molecular navigation system. Areas covered: The merging of phage display technologies with nanotechnology in recent years has proved promising in different areas of medicine and technology, such as medical diagnostics, molecular imaging, vaccine development and targeted drug/gene delivery, which is the focus of this review. The authors used data obtained from their research group and sourced using Science Citation Index (Web of Science) and NCBI PubMed search resources. Expert opinion: First attempts of adapting traditional concepts of direct targeting of tumor using phage-targeted nanomedicines has shown minimal improvements. With discovery and study of biological and technical barriers that prevent anti-tumor drug delivery, a paradigm shift from traditional drug targeting to nanomedicine navigation systems is required. The advanced bacteriophage-driven self-navigation systems are thought to overcome those barriers using more precise, localized phage selection methods, multi-targeting 'promiscuous' ligands and advanced multifunctional nanomedicine platforms.

Paradigm shifts in fish conservation: moving to the ecosystem services concept.

PubMed

Cowx, I G; Portocarrero Aya, M

2011-12-01

Various factors constrain the existence and development of inland fishes and fisheries, such as pollution, habitat degradation, alien invasive species, local user conflicts, low social priority and inadequate research and funding. In many cases, however, degradation of the environment and loss of aquatic habitat are the predominant concerns for the conservation of freshwater aquatic biota. The need for concerted effort to prevent and reduce environmental degradation, as well as protection of freshwater fishes and fisheries as renewable common pool resources or entities in their own right, are the greatest challenges facing the conservation of fishes in inland waters. Unfortunately, traditional conservation practices such as regulation of exploitation, protected areas and habitat restoration have failed to arrest the alarming increase in number of threatened freshwater fish species worldwide. This paper examines the shifting paradigm of fisheries management from rule-based regulation, through fishery enhancement towards the ecosystem approach to fisheries, with reference to inland waters, and how the emerging concept of ecosystem services coupled with traditional fish conservation management practices, institutional restructuring and integrated management planning should provide a more sustainable thrust to formulation and promotion of fish conservation initiatives. © 2011 The Authors. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

The interface between forensic science and technology: how technology could cause a paradigm shift in the role of forensic institutes in the criminal justice system.

PubMed

Kloosterman, Ate; Mapes, Anna; Geradts, Zeno; van Eijk, Erwin; Koper, Carola; van den Berg, Jorrit; Verheij, Saskia; van der Steen, Marcel; van Asten, Arian

2015-08-05

In this paper, the importance of modern technology in forensic investigations is discussed. Recent technological developments are creating new possibilities to perform robust scientific measurements and studies outside the controlled laboratory environment. The benefits of real-time, on-site forensic investigations are manifold and such technology has the potential to strongly increase the speed and efficacy of the criminal justice system. However, such benefits are only realized when quality can be guaranteed at all times and findings can be used as forensic evidence in court. At the Netherlands Forensic Institute, innovation efforts are currently undertaken to develop integrated forensic platform solutions that allow for the forensic investigation of human biological traces, the chemical identification of illicit drugs and the study of large amounts of digital evidence. These platforms enable field investigations, yield robust and validated evidence and allow for forensic intelligence and targeted use of expert capacity at the forensic institutes. This technological revolution in forensic science could ultimately lead to a paradigm shift in which a new role of the forensic expert emerges as developer and custodian of integrated forensic platforms. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Advances and Challenges in Treatment of Locally Advanced Rectal Cancer

PubMed Central

Smith, J. Joshua; Garcia-Aguilar, Julio

2015-01-01

Dramatic improvements in the outcomes of patients with rectal cancer have occurred over the past 30 years. Advances in surgical pathology, refinements in surgical techniques and instrumentation, new imaging modalities, and the widespread use of neoadjuvant therapy have all contributed to these improvements. Several questions emerge as we learn of the benefits or lack thereof for components of the current multimodality treatment in subgroups of patients with nonmetastatic locally advanced rectal cancer (LARC). What is the optimal surgical technique for distal rectal cancers? Do all patients need postoperative chemotherapy? Do all patients need radiation? Do all patients need surgery, or is a nonoperative, organ-preserving approach warranted in selected patients? Answering these questions will lead to more precise treatment regimens, based on patient and tumor characteristics, that will improve outcomes while preserving quality of life. However, the idea of shifting the treatment paradigm (chemoradiotherapy, total mesorectal excision, and adjuvant therapy) currently applied to all patients with LARC to a more individually tailored approach is controversial. The paradigm shift toward organ preservation in highly selected patients whose tumors demonstrate clinical complete response to neoadjuvant treatment is also controversial. Herein, we highlight many of the advances and resultant controversies that are likely to dominate the research agenda for LARC in the modern era. PMID:25918296

Complex systems thinking in emergency medicine: A novel paradigm for a rapidly changing and interconnected health care landscape.

PubMed

Widmer, Matthew A; Swanson, R Chad; Zink, Brian J; Pines, Jesse M

2017-12-27

The specialty of emergency medicine is experiencing the convergence of a number of transformational forces in the United States, including health care reform, technological advancements, and societal shifts. These bring both opportunity and uncertainty. 21ST CENTURY CHALLENGES: Persistent challenges such as the opioid epidemic, rising health care costs, misaligned incentives, patients with multiple chronic diseases, and emergency department crowding continue to plague the acute, unscheduled care system. The traditional approach to health care practice and improvement-reductionism-is not adequate for the complexity of the twenty-first century. Reductionist thinking will likely continue to produce unintended consequences and suboptimal outcomes. Complex systems thinking provides a perspective and set of tools better suited for the challenges and opportunities facing public health in general, and emergency medicine more specifically. This article introduces complex systems thinking and argues for its application in the context of emergency medicine by drawing on the history of the circumstances surrounding the formation of the specialty and by providing examples of its application to several practice challenges. © 2017 John Wiley & Sons, Ltd.

Addiction: the urgent need for a paradigm shift.

PubMed

Alexander, Bruce K

2012-01-01

Severe addictions to drug use and to countless other habits are causing enormous harm around the globe. Massive expenditures and dedicated efforts of police, doctors, addiction therapists, and self-help groups have failed to bring the problem under control, although many individual addicts have been helped. What can society do when our best efforts continue to fail and a menacing problem continues to grow? This paper proposes that a major paradigm shift is required. The currently dominant paradigm assumes that addiction is either an individual disease or an individual moral breach. But this individually oriented paradigm has failed. Instead, addiction needs to be understood socially, as a way that large numbers of people adapt to the breakdown of psychologically sustaining culture under the global influence of free-market society. This new paradigm is based on the social thinking of Karl Polanyi and other social scientists rather than on the individual thinking of neuroscientists, doctors, or psychologists.

Cranial Stereotactic Radiosurgery: Current Status of the Initial Paradigm Shifter

PubMed Central

Sheehan, Jason P.; Yen, Chun-Po; Lee, Cheng-Chia; Loeffler, Jay S.

2014-01-01

The concept of stereotactic radiosurgery (SRS) was first described by Lars Leksell in 1951. It was proposed as a noninvasive alternative to open neurosurgical approaches to manage a variety of conditions. In the following decades, SRS emerged as a unique discipline involving a collegial partnership among neurosurgeons, radiation oncologists, and medical physicists. SRS relies on the precisely guided delivery of high-dose ionizing radiation to an intracranial target. The focused convergence of multiple beams yields a potent therapeutic effect on the target and a steep dose fall-off to surrounding structures, thereby minimizing the risk of collateral damage. SRS is typically administered in a single session but can be given in as many as five sessions or fractions. By providing an ablative effect noninvasively, SRS has altered the treatment paradigms for benign and malignant intracranial tumors, functional disorders, and vascular malformations. Literature on extensive intracranial radiosurgery has unequivocally demonstrated the favorable benefit-to-risk profile that SRS affords for appropriately selected patients. In a departure from conventional radiotherapeutic strategies, radiosurgical principles have recently been extended to extracranial indications such as lung, spine, and liver tumors. The paradigm shift resulting from radiosurgery continues to alter the landscape of related fields. PMID:25113762

Turbomachinery computational fluid dynamics: asymptotes and paradigm shifts.

PubMed

Dawes, W N

2007-10-15

This paper reviews the development of computational fluid dynamics (CFD) specifically for turbomachinery simulations and with a particular focus on application to problems with complex geometry. The review is structured by considering this development as a series of paradigm shifts, followed by asymptotes. The original S1-S2 blade-blade-throughflow model is briefly described, followed by the development of two-dimensional then three-dimensional blade-blade analysis. This in turn evolved from inviscid to viscous analysis and then from steady to unsteady flow simulations. This development trajectory led over a surprisingly small number of years to an accepted approach-a 'CFD orthodoxy'. A very important current area of intense interest and activity in turbomachinery simulation is in accounting for real geometry effects, not just in the secondary air and turbine cooling systems but also associated with the primary path. The requirements here are threefold: capturing and representing these geometries in a computer model; making rapid design changes to these complex geometries; and managing the very large associated computational models on PC clusters. Accordingly, the challenges in the application of the current CFD orthodoxy to complex geometries are described in some detail. The main aim of this paper is to argue that the current CFD orthodoxy is on a new asymptote and is not in fact suited for application to complex geometries and that a paradigm shift must be sought. In particular, the new paradigm must be geometry centric and inherently parallel without serial bottlenecks. The main contribution of this paper is to describe such a potential paradigm shift, inspired by the animation industry, based on a fundamental shift in perspective from explicit to implicit geometry and then illustrate this with a number of applications to turbomachinery.

Macrostrategies: Creating Paradigm-versus-Paradigm Thinking.

ERIC Educational Resources Information Center

Hill, Larry K.

1991-01-01

Responds to "macrostrategies" concept in counseling advanced in previous articles by Herr, Ivey and Rigazio-DiGilio, and Dinkmeyer relative to broadening the service delivery perspective of the profession and thereby sustaining its heritage. Claims this work contributes significantly to strengthening a paradigm shift in that direction.…

Contemporary management of low--grade glioma: a paradigm shift in neuro-oncology.

PubMed

Hayhurst, Caroline

2017-06-01

Supratentorial diffuse intrinsic low-grade gliomas represent a distinct but heterogenous group of tumours, with the propensity to grow and to differentiate into malignant tumours. They have been historically viewed in the 'benign' spectrum of intrinsic brain tumours, so a watch-and-wait policy was often adopted. With recent advances in our understanding of the natural history of these tumours, combined with advances in surgical technique, an aggressive approach is now recommended. Increasing quality evidence of the impact of tumour resection and multicentre trials of adjuvant radiotherapy and chemotherapy have led to a new algorithm for low-grade glioma management. This review aims to outline the emerging evidence that has shifted neuro-oncology practice. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

[Hyperkalemia - current therapuetic strategies].

PubMed

Głogowski, Tomasz; Wojtaszek, Ewa

Hyperkalemia is a medical emergency that requires immediate therapy, followed by interventions aimed at preventing its recurrence. Hyperkalemia occurs especially frequently in patients with chronic kidney disease (CKD), in part because of impaired kidney function and in part due to coexisting comorbidities such as diabetes or heart failure and the medications used to treat them, first of all the inhibitors of renin-angiotensin-aldosterone system (RAASi). Both acute and chronic management of hyperkalemia are equally important, though, with currently available therapeutic possibilities, the effective restoration of potassium homeostasis are in fact limited to the correction of its triggers. The emergence of new medications (patiromer and ZS-9) could lead to a therapeutic paradigm shift from intermittent treatment of incidentally discovered hyperkalemia toward preventive measures preventing fluctuations in serum potassium levels and enabling the continuation of beneficial, but hyperkalemia inducing agents.

Towards Conceptualizing Child Wellbeing in India: The Need for a Paradigm Shift

PubMed Central

Saith, Ashwani

2010-01-01

Globally, there is a vast array of social indicators, many of these specifically oriented to the lives, experience and needs of children. This approach is much more advanced in developed economies and rich countries, where the focus has widened and shifted progressively towards a full recognition of the non-monetary dimensions of child wellbeing. At present, there would appear to be a propitious academic, activist and policy conjuncture for the widening of the discourse on child deprivation in India. This environment is created partly by the emerging reporting requirements and exhortations of the international development regime. But it is also fuelled by dissatisfaction over the inability of the existing methodologies, dominated by the reductionist monetary poverty line approach, to provide a meaningful intellectual or operational frame for contending with issues of child wellbeing in a holistic manner. The basic argument of this paper is that a double paradigm shift is urgently necessary: from mainstream approaches which tend to focus overwhelmingly on the material poverty and deprivation experienced by some children, deemed by definition to be those in households-in-poverty, to one that widens the field of vision to include both material and non-material dimensions of wellbeing of all children. Clearly, fresh epistemological and methodological challenges will have to be met with innovative and creative responses. It is time for India to catch up with best practices in rich countries, and given the impressive dimensions of India’s academic and professional infrastructure, this should not be an unrealistic goal. PMID:20543882

The 2014 Academic College of Emergency Experts in India's INDO-US Joint Working Group (JWG) White Paper on “Developing Trauma Sciences and Injury Care in India”

PubMed Central

Pal, Ranabir; Agarwal, Amit; Galwankar, Sagar; Swaroop, Mamta; Stawicki, Stanislaw P; Rajaram, Laxminarayan; Paladino, Lorenzo; Aggarwal, Praveen; Bhoi, Sanjeev; Dwivedi, Sankalp; Menon, Geetha; Misra, MC; Kalra, OP; Singh, Ajai; Radjou, Angeline Neetha; Joshi, Anuja

2014-01-01

It is encouraging to see the much needed shift in the understanding and recognition of the concept of “burden of disease” in the context of traumatic injury. Equally important is understanding that the impact of trauma burden rivals that of nontraumatic morbidities. Subsequently, this paradigm shift reinstates the appeal for timely interventions as the standard for management of traumatic emergencies. Emergency trauma care in India has been disorganized due to inadequate sensitivity toward patients affected by trauma as well as the haphazard, nonuniform acceptance of standardization as the norm. Some of the major hospitals across various regions in the country do have trauma care units, but even those lack protocols to ensure that all trauma cases are handled by those units, largely owing to lack of structured referral system. As a first step to reform the state of trauma care in the country, a detailed overview is needed to gain insight into the prevailing reality. The objectives of this paper are to thus weave a foundation based on the statistical and qualitative burden of trauma in the country; the available infrastructure of trauma care centers equipped to deal with trauma; the need and scope of standardized protocols for intervention; and most importantly, the application of these in shaping educational initiatives in advancing emergency trauma care in the country. PMID:25024939

Is This the Paradigm Shift We Need?

ERIC Educational Resources Information Center

Mirvis, Jonathan

2012-01-01

Dr. Woocher's essay, states Mirvis, is seminal in the field of Jewish education. It proposes a new paradigm for Jewish education in North America. This proposed paradigm is supported by a comprehensive multi-disciplinary research drawing on literature from education, philosophy, history, sociology, psychology, and economics. The essay reflects a…

The rise of neglected tropical diseases in the "new Texas".

PubMed

Hotez, Peter J

2018-01-01

Within the last five years, the State of Texas has experienced either transmission or outbreaks of Ebola, chikungunya, West Nile, and Zika virus infections. Autochthonous transmission of neglected parasitic and bacterial diseases has also become increasingly reported. The rise of such emerging and neglected tropical diseases (NTDs) has not occurred by accident but instead reflects rapidly evolving changes and shifts in a "new" Texas beset by modern and globalizing forces that include rapid expansions in population together with urbanization and human migrations, altered transportation patterns, climate change, steeply declining vaccination rates, and a new paradigm of poverty known as "blue marble health." Summarized here are the major NTDs now affecting Texas. In addition to the vector-borne viral diseases highlighted above, there also is a high level of parasitic infections, including Chagas disease, trichomoniasis, and possibly leishmaniasis and toxocariasis, as well as typhus-group rickettsiosis, a vector-borne bacterial infection. I also highlight some of the key shifts in emerging and neglected disease patterns, partly due to an altered and evolving economic and ecological landscape in the new Texas, and provide some preliminary disease burden estimates for the major prevalent and incident NTDs.

Charting the expansion of strategic exploratory behavior during adolescence.

PubMed

Somerville, Leah H; Sasse, Stephanie F; Garrad, Megan C; Drysdale, Andrew T; Abi Akar, Nadine; Insel, Catherine; Wilson, Robert C

2017-02-01

Although models of exploratory decision making implicate a suite of strategies that guide the pursuit of information, the developmental emergence of these strategies remains poorly understood. This study takes an interdisciplinary perspective, merging computational decision making and developmental approaches to characterize age-related shifts in exploratory strategy from adolescence to young adulthood. Participants were 149 12-28-year-olds who completed a computational explore-exploit paradigm that manipulated reward value, information value, and decision horizon (i.e., the utility that information holds for future choices). Strategic directed exploration, defined as information seeking selective for long time horizons, emerged during adolescence and maintained its level through early adulthood. This age difference was partially driven by adolescents valuing immediate reward over new information. Strategic random exploration, defined as stochastic choice behavior selective for long time horizons, was invoked at comparable levels over the age range, and predicted individual differences in attitudes toward risk taking in daily life within the adolescent portion of the sample. Collectively, these findings reveal an expansion of the diversity of strategic exploration over development, implicate distinct mechanisms for directed and random exploratory strategies, and suggest novel mechanisms for adolescent-typical shifts in decision making. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

The Immune Landscape of Non-Small Cell Lung Cancer: Utility of Cytologic and Histologic Samples Obtained Through Minimally Invasive Pulmonary Procedures.

PubMed

Beattie, Jason; Yarmus, Lonny; Wahidi, Momen M; Rivera, M Patricia; Gilbert, Christopher; Maldonado, Fabien; Czarnecka, Kasia; Argento, Angela; Chen, Alexander; Herth, Felix; Sterman, Daniel H

2018-05-14

The success of immune checkpoint inhibitors and the discovery of useful biomarkers to predict response to these agents is shifting much of the focus of personalized care for non-small cell lung cancer towards harnessing the immune response. With further advancement, more effective immunotherapy options will emerge along with more useful biomarkers. Paradoxically, minimally invasive small biopsy and cytology specimens have become the primary method for diagnosis of patients with advanced disease, as well for initial diagnosis and staging in earlier stage disease. For the benefit of these patients, we will continue to learn how to do more with less. In this perspective, we review aspects of immunobiology that underlie the current state of the art of existing and emerging immunologic biomarkers that hold potential to enhance the care of patients with non-small cell lung cancer. We address practical considerations for acquiring patient samples that accurately reflect disease immune status. We also propose a paradigm shift wherein the most important sample types that need to be proven in pioneering basic science and translation work and subsequent clinical trials are the specimens most often obtained clinically.

Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering.

PubMed

Marcucio, Ralph S; Qin, Ling; Alsberg, Eben; Boerckel, Joel D

2017-11-01

The fields of developmental biology and tissue engineering have been revolutionized in recent years by technological advancements, expanded understanding, and biomaterials design, leading to the emerging paradigm of "developmental" or "biomimetic" tissue engineering. While developmental biology and tissue engineering have long overlapping histories, the fields have largely diverged in recent years at the same time that crosstalk opportunities for mutual benefit are more salient than ever. In this perspective article, we will use musculoskeletal development and tissue engineering as a platform on which to discuss these emerging crosstalk opportunities and will present our opinions on the bright future of these overlapping spheres of influence. The multicellular programs that control musculoskeletal development are rapidly becoming clarified, represented by shifting paradigms in our understanding of cellular function, identity, and lineage specification during development. Simultaneously, advancements in bioartificial matrices that replicate the biochemical, microstructural, and mechanical properties of developing tissues present new tools and approaches for recapitulating development in tissue engineering. Here, we introduce concepts and experimental approaches in musculoskeletal developmental biology and biomaterials design and discuss applications in tissue engineering as well as opportunities for tissue engineering approaches to inform our understanding of fundamental biology. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2356-2368, 2017. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Sub-specialization in plastic surgery in Sub-saharan Africa: capacities, gaps and opportunities

PubMed Central

Ibrahim, Abdulrasheed

2014-01-01

The skill set of a plastic surgeon, which addresses a broad range of soft tissue conditions that are prevalent in sub-Saharan Africa, remains relevant in the unmet need for surgical care. Recently, there has being a major paradigm shift from discipline-based to disease-based care, resulting in an emerging component of patient-centered care; adequate access to subspecialty care in plastic and reconstructive surgery. Given the need for an evolution in sub-specialization, this article focuses on the benefits and future role of differentiation of plastic surgeons into sub-specialty training pathways in sub-Saharan Africa. PMID:25584125

Metal Additive Manufacturing: A Review

NASA Astrophysics Data System (ADS)

Frazier, William E.

2014-06-01

This paper reviews the state-of-the-art of an important, rapidly emerging, manufacturing technology that is alternatively called additive manufacturing (AM), direct digital manufacturing, free form fabrication, or 3D printing, etc. A broad contextual overview of metallic AM is provided. AM has the potential to revolutionize the global parts manufacturing and logistics landscape. It enables distributed manufacturing and the productions of parts-on-demand while offering the potential to reduce cost, energy consumption, and carbon footprint. This paper explores the material science, processes, and business consideration associated with achieving these performance gains. It is concluded that a paradigm shift is required in order to fully exploit AM potential.

Regenerative Rehabilitation – a New Future?

PubMed Central

Perez-Terzic, Carmen; Childers, Martin K.

2014-01-01

Modern rehabilitation medicine is propelled by newfound knowledge aimed at offering solutions for an increasingly aging population afflicted by chronic debilitating conditions. Considered a core component of future healthcare, the roll-out of regenerative medicine underscores a paradigm shift in patient management targeted at restoring physiologic function and restituting normative impact. Nascent regenerative technologies offer unprecedented prospects in achieving repair of degenerated, diseased or damaged tissues. In this context, principles of regenerative science are increasingly integrated in rehabilitation practices as illustrated in the present Supplement. Encompassing a growing multidisciplinary domain, the emergent era of “regenerative rehabilitation” brings radical innovations at the forefront of healthcare blueprints. PMID:25310603

Serotonergic hallucinogens and emerging targets for addiction pharmacotherapies.

PubMed

Ross, Stephen

2012-06-01

Only time will tell if serotonergic hallucinogen-assisted psychotherapy treatment paradigms for SUDs will prove to be safe and effective in double-blind, placebo-controlled clinical trials. If they are, they would truly constitute a novel psychopharmacologic-psychosocial treatment paradigm to treat addictive disorders, although the risk of adverse psychological events would have to be controlled through a careful screening process and the risk of misuse of the substances or developing use syndromes would have to be considered, although the overall risk would be low because, as mentioned, SHs are unlike all other drugs of abuse in that they do not appear to produce dependence syndromes. There effects on the NA and DA range from inhibition to slight activation, all this without producing addiction. The ability of these medicinal tools to treat a range of addictive, psychiatric, and existential disorders is remarkable in scope and possibility. They truly represent a potential paradigmatic shift within the field of psychiatry, too interesting to not explore further.

Paradigms and public policies on drought in northeast Brazil: a historical perspective.

PubMed

Campos, José Nilson B

2015-05-01

This paper describes the evolution of drought-related public policies in Northeast Brazil (NEB). Using a historical approach, we show that the evolution of public policy has not been characterized by abrupt shifts, but has instead been shaped through debates between renowned intellectuals. The resulting public policies formed a hydrological infrastructure that delivers clean water needed for robust economic activity. However, outcomes of the 2012-2013 drought show that populations that depend on rain fed agriculture are as vulnerable to drought as they were at the start of the 20th century. Although government, social, and emergency programs have aided drought victims, drought analysts agree that rain fed agriculture has remained vulnerable since drought policies were first formulated. Drought policies formulate integrated water resources management (IWRM) strategies that are geared toward supplying safe drinking water, and debates surrounding the IWRM paradigm have been affected by outcomes of major international events such as the World Water Forum.

Inertial sensors to quantify the pivot shift test in the treatment of anterior cruciate ligament injury

PubMed Central

ZAFFAGNINI, STEFANO; LOPOMO, NICOLA; SIGNORELLI, CECILIA; MUCCIOLI, GIULIO MARIA MARCHEGGIANI; BONANZINGA, TOMMASO; GRASSI, ALBERTO; RAGGI, FEDERICO; VISANI, ANDREA; MARCACCI, MAURILIO

2014-01-01

The main purpose of this article was to describe in detail, from the perspective of the clinical end user, a previously presented non-invasive methodology, applied in the treatment of anterior cruciate ligament injury, in which inertial sensors are used to quantify the pivot shift test. The outcomes obtained and relative considerations were compared with findings emerging from a review of the relevant updated literature. The detailed description here provided covers the system, the parameters identified and the testing procedure; it also includes the technical specifications of the hardware, the features introduced in the updated version of the software and the application of the system in clinical practice. The comparison of the technical considerations and clinical results with the updated literature confirmed the system’s optimal ergonomics, good reproducibility and clinical reliability. The novel approach here analyzed has been shown to overcome the weaknesses of other available devices and systems. Therefore, since it can be considered a new paradigm in the quantification of pivot shift test, we can recommend its routine use in clinical practice. PMID:25606555

Understanding and Implementing the CLT (Communicative Language Teaching) Paradigm

ERIC Educational Resources Information Center

Jacobs, George M.; Farell, Thomas S. C.

2003-01-01

The call to change seems to be a constant in education. In second language education, a constellation of changes have been proposed and, to some extent, implemented. This constellation of interconnected changes can perhaps best be termed a paradigm shift, with this paradigm fitting under the general umbrella of Communicative Language Teaching…

Paradigmatic and Presumptive Shifts: Thomas Kuhn and Richard Whately in Tandem.

ERIC Educational Resources Information Center

Miller, Christine M.

Acceptance of a paradigm in the scientific community depends upon persuasion, upon the supplying of "good reasons" for supporting one paradigm over another. When one paradigm gains long-term acceptance and becomes the standard for scientific thought, scientists defer to such an authority in their thinking, and such established paradigms…

E-health beyond technology: analyzing the paradigm shift that lies beneath.

PubMed

Moerenhout, Tania; Devisch, Ignaas; Cornelis, Gustaaf C

2018-03-01

Information and computer technology has come to play an increasingly important role in medicine, to the extent that e-health has been described as a disruptive innovation or revolution in healthcare. The attention is very much focused on the technology itself, and advances that have been made in genetics and biology. This leads to the question: What is changing in medicine today concerning e-health? To what degree could these changes be characterized as a 'revolution'? We will apply the work of Thomas Kuhn, Larry Laudan, Michel Foucault and other philosophers-which offers an alternative understanding of progress and revolution in medicine to the classic discovery-oriented approach-to our analysis. Nowadays, the long-standing curative or reactive paradigm in medicine is facing a crisis due to an aging population, a significant increase in chronic diseases and the development of more expensive diagnostic tools and therapies. This promotes the evolution towards a new paradigm with an emphasis on preventive medicine. E-health constitutes an essential part of this new paradigm that seeks to solve the challenges presented by an aging population, skyrocketing costs and so forth. Our approach changes the focus from the technology itself toward the underlying paradigm shift in medicine. We will discuss the relevance of this approach by applying it to the surge in digital self-tracking through health apps and wearables: the recognition of the underlying paradigm shift leads to a more comprehensive understanding of self-tracking than a solely discovery-oriented or technology-focused view can provide.

Anti-vaccine activists, Web 2.0, and the postmodern paradigm--an overview of tactics and tropes used online by the anti-vaccination movement.

PubMed

Kata, Anna

2012-05-28

Websites opposing vaccination are prevalent on the Internet. Web 2.0, defined by interaction and user-generated content, has become ubiquitous. Furthermore, a new postmodern paradigm of healthcare has emerged, where power has shifted from doctors to patients, the legitimacy of science is questioned, and expertise is redefined. Together this has created an environment where anti-vaccine activists are able to effectively spread their messages. Evidence shows that individuals turn to the Internet for vaccination advice, and suggests such sources can impact vaccination decisions - therefore it is likely that anti-vaccine websites can influence whether people vaccinate themselves or their children. This overview examines the types of rhetoric individuals may encounter online in order to better understand why the anti-vaccination movement can be convincing, despite lacking scientific support for their claims. Tactics and tropes commonly used to argue against vaccination are described. This includes actions such as skewing science, shifting hypotheses, censoring dissent, and attacking critics; also discussed are frequently made claims such as not being "anti-vaccine" but "pro-safe vaccines", that vaccines are toxic or unnatural, and more. Recognizing disingenuous claims made by the anti-vaccination movement is essential in order to critically evaluate the information and misinformation encountered online. Copyright © 2011 Elsevier Ltd. All rights reserved.

Data-Intensive Science Meets Inquiry-Driven Pedagogy: Interactive Big Data Exploration, Threshold Concepts, and Liminality

NASA Astrophysics Data System (ADS)

Ramachandran, R.; Nair, U. S.; Word, A.

2014-12-01

Threshold concepts in any discipline are the core concepts an individual must understand in order to master a discipline. By their very nature, these concepts are troublesome, irreversible, integrative, bounded, discursive, and reconstitutive. Although grasping threshold concepts can be extremely challenging for each learner as s/he moves through stages of cognitive development relative to a given discipline, the learner's grasp of these concepts determines the extent to which s/he is prepared to work competently and creatively within the field itself. The movement of individuals from a state of ignorance of these core concepts to one of mastery occurs not along a linear path but in iterative cycles of knowledge creation and adjustment in liminal spaces - conceptual spaces through which learners move from the vaguest awareness of concepts to mastery, accompanied by understanding of their relevance, connectivity, and usefulness relative to questions and constructs in a given discipline. With the explosive growth of data available in atmospheric science, driven largely by satellite Earth observations and high-resolution numerical simulations, paradigms such as that of data-intensive science have emerged. These paradigm shifts are based on the growing realization that current infrastructure, tools and processes will not allow us to analyze and fully utilize the complex and voluminous data that is being gathered. In this emerging paradigm, the scientific discovery process is driven by knowledge extracted from large volumes of data. In this presentation, we contend that this paradigm naturally lends to inquiry-driven pedagogy where knowledge is discovered through inductive engagement with large volumes of data rather than reached through traditional, deductive, hypothesis-driven analyses. In particular, data-intensive techniques married with an inductive methodology allow for exploration on a scale that is not possible in the traditional classroom with its typical problem sets and static, limited data samples. In addition, we identify existing gaps and possible solutions for addressing the infrastructure and tools as well as a pedagogical framework through which to implement this inductive approach.

Paradigm Shift Additive Manufacturing and the New Way of War

DTIC Science & Technology

2016-12-01

keep costs low: Simple parts are easier to make. Once a product design has been selected and tooling has been obtained, a change in design becomes...adversary’s OODA loop through rapid design and manufacturing . We need to do this; enable this capabil- ity now before our adversaries do, as they might not...35 Defense AT&L: November-December 2016 Paradigm Shift Additive Manufacturing and the New Way of War Brett P. Conner Conner is an associate

The role of the NGDO Coordination Group for the Elimination of Onchocerciasis.

PubMed

Elhassan, Elizabeth; Zhang, Yaobi; Bush, Simon; Molyneux, David; Kollmann, Martin K H; Sodahlon, Yao; Richards, Frank

2018-03-01

The NGDO Coordination Group for the Control of Onchocerciasis was launched in 1992, and with the paradigm shift from control of disease to elimination of onchocerciasis transmission, the Group shifted its orientation to that new paradigm in 2013. It also changed its name, replacing 'control' with 'elimination.' In doing so, the Group has repositioned itself to build on the successes of the past to finish the job it began over 25 years ago.

Ready for a paradigm shift? Part 1: introducing the philosophy of qualitative research.

PubMed

Petty, Nicola J; Thomson, Oliver P; Stew, Graham

2012-08-01

The manual therapy professions have almost exclusively focused on the use of quantitative research to help inform their practices. This paper argues that a greater use of qualitative research will help develop a more robust and comprehensive knowledge base in manual therapy. The types of knowledge used in practice and generated from the two research paradigms are explored. It is hoped that an understanding of the philosophical and theoretical underpinnings of qualitative research may encourage more manual therapists to value and use this approach to help further inform their practice; for some, this may involve a paradigm shift in thinking. Copyright © 2012 Elsevier Ltd. All rights reserved.

From Special Education to an Inclusive, Outcomes-Based System.

ERIC Educational Resources Information Center

Naicker, Sigamoney

2001-01-01

This article discusses shifting from special education to inclusive, outcomes-based education (OBE) in South Africa. It examines why there is a shift toward OBE, different educational paradigms, and shifting from fundamental pedagogy to OBE. Necessary changes are highlighted, and include a shift from classification to using OBE for progression and…

Cranial stereotactic radiosurgery: current status of the initial paradigm shifter.

PubMed

Sheehan, Jason P; Yen, Chun-Po; Lee, Cheng-Chia; Loeffler, Jay S

2014-09-10

The concept of stereotactic radiosurgery (SRS) was first described by Lars Leksell in 1951. It was proposed as a noninvasive alternative to open neurosurgical approaches to manage a variety of conditions. In the following decades, SRS emerged as a unique discipline involving a collegial partnership among neurosurgeons, radiation oncologists, and medical physicists. SRS relies on the precisely guided delivery of high-dose ionizing radiation to an intracranial target. The focused convergence of multiple beams yields a potent therapeutic effect on the target and a steep dose fall-off to surrounding structures, thereby minimizing the risk of collateral damage. SRS is typically administered in a single session but can be given in as many as five sessions or fractions. By providing an ablative effect noninvasively, SRS has altered the treatment paradigms for benign and malignant intracranial tumors, functional disorders, and vascular malformations. Literature on extensive intracranial radiosurgery has unequivocally demonstrated the favorable benefit-to-risk profile that SRS affords for appropriately selected patients. In a departure from conventional radiotherapeutic strategies, radiosurgical principles have recently been extended to extracranial indications such as lung, spine, and liver tumors. The paradigm shift resulting from radiosurgery continues to alter the landscape of related fields. © 2014 by American Society of Clinical Oncology.

Stream of consciousness: Quantum and biochemical assumptions regarding psychopathology.

PubMed

Tonello, Lucio; Cocchi, Massimo; Gabrielli, Fabio; Tuszynski, Jack A

2017-04-01

The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousness seem to offer a profound change to the current approaches. Unfortunately these quantum paradigms harbor at least two serious problems. First, they are simply models, theories, and assumptions, with no convincing experiments supporting their claims. Second, they deviate from contemporary mainstream views of psychiatric illness and do so in revolutionary ways. We suggest a possible way to integrate experimental neuroscience with quantum models in order to address outstanding issues in psychopathology. A key role is played by the phenomenon called the "stream of consciousness", which can be linked to the so-called "Gamma Synchrony" (GS), which is clearly demonstrated by EEG data. In our novel proposal, a unipolar depressed patient could be seen as a subject with an altered stream of consciousness. In particular, some clues suggest that depression is linked to an "increased power" stream of consciousness. It is additionally suggested that such an approach to depression might be extended to psychopathology in general with potential benefits to diagnostics and therapeutics in neuropsychiatry. Copyright © 2017 Elsevier Ltd. All rights reserved.

The genesis of neurosurgery and the evolution of the neurosurgical operative environment: part II--concepts for future development, 2003 and beyond.

PubMed

Liu, Charles Y; Spicer, Mark; Apuzzo, Michael L J

2003-01-01

The future development of the neurosurgical operative environment is driven principally by concurrent development in science and technology. In the new millennium, these developments are taking on a Jules Verne quality, with the ability to construct and manipulate the human organism and its surroundings at the level of atoms and molecules seemingly at hand. Thus, an examination of currents in technology advancement from the neurosurgical perspective can provide insight into the evolution of the neurosurgical operative environment. In the future, the optimal design solution for the operative environment requirements of specialized neurosurgery may take the form of composites of venues that are currently mutually distinct. Advances in microfabrication technology and laser optical manipulators are expanding the scope and role of robotics, with novel opportunities for bionic integration. Assimilation of biosensor technology into the operative environment promises to provide neurosurgeons of the future with a vastly expanded set of physiological data, which will require concurrent simplification and optimization of analysis and presentation schemes to facilitate practical usefulness. Nanotechnology derivatives are shattering the maximum limits of resolution and magnification allowed by conventional microscopes. Furthermore, quantum computing and molecular electronics promise to greatly enhance computational power, allowing the emerging reality of simulation and virtual neurosurgery for rehearsal and training purposes. Progressive minimalism is evident throughout, leading ultimately to a paradigm shift as the nanoscale is approached. At the interface between the old and new technological paradigms, issues related to integration may dictate the ultimate emergence of the products of the new paradigm. Once initiated, however, history suggests that the process of change will proceed rapidly and dramatically, with the ultimate neurosurgical operative environment of the future being far more complex in functional capacity but strikingly simple in apparent form.

Epistemology of Contaminants of Emerging Concern and Literature Meta-analysis

PubMed Central

Halden, Rolf U.

2014-01-01

A meta-analysis was conducted to inform the epistemology, or theory of knowledge, of contaminants of emerging concern (CECs). The CEC terminology acknowledges the existence of harmful environmental agents whose identities, occurrences, hazards, and effects are not sufficiently understood. Here, data on publishing activity were analyzed for 12 CECs, revealing a common pattern of emergence, suitable for identifying past years of peak concern and forecasting future ones: dichlorodiphenyltrichloroethane (DDT; 1972, 2008), trichloroacetic acid (TCAA; 1972, 2009), nitrosodimethylamine (1984), methyl tert-butyl ether (2001), trichloroethylene (2005), perchlorate (2006), 1,4-dioxane (2009), prions (2009), triclocarban (2010), triclosan (2012), nanomaterials (by 2016), and microplastics (2022 ± 4). CECs were found to emerge from obscurity to the height of concern in 14.1 ± 3.6 years, and subside to a new baseline level of concern in 14.5 ± 4.5 years. CECs can emerge more than once (e.g., TCAA, DDT) and the multifactorial process of emergence may be driven by inception of novel scientific methods (e.g., ion chromatography, mass spectrometry and nanometrology), scientific paradigm shifts (discovery of infectious proteins), and the development, marketing and mass consumption of novel products (antimicrobial personal care products, microplastics and nanomaterials). Publishing activity and U.S. regulatory actions were correlated for several CECs investigated. PMID:25294779

Emerging viruses in the Felidae: shifting paradigms.

PubMed

O'Brien, Stephen J; Troyer, Jennifer L; Brown, Meredith A; Johnson, Warren E; Antunes, Agostinho; Roelke, Melody E; Pecon-Slattery, Jill

2012-02-01

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids.

Emerging Viruses in the Felidae: Shifting Paradigms

PubMed Central

O’Brien, Stephen J.; Troyer, Jennifer L.; Brown, Meredith A.; Johnson, Warren E.; Antunes, Agostinho; Roelke, Melody E.; Pecon-Slattery, Jill

2012-01-01

The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids. PMID:22470834

Early management of acute pancreatitis: A review of the best evidence.

PubMed

Stigliano, Serena; Sternby, Hanna; de Madaria, Enrique; Capurso, Gabriele; Petrov, Maxim S

2017-06-01

In the 20th century early management of acute pancreatitis often included surgical intervention, despite overwhelming mortality. The emergence of high-quality evidence (randomized controlled trials and meta-analyses) over the past two decades has notably shifted the treatment paradigm towards predominantly non-surgical management early in the course of acute pancreatitis. The present evidence-based review focuses on contemporary aspects of early management (which include analgesia, fluid resuscitation, antibiotics, nutrition, and endoscopic retrograde cholangiopancreatography) with a view to providing clear and succinct guidelines on early management of patients with acute pancreatitis in 2017 and beyond. Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Paradigms, Mental Models, and Mind-Sets: Triple Barriers to Transformational Change in School Systems

ERIC Educational Resources Information Center

Duffy, Francis M.

2014-01-01

This article presents a simile for understanding the power of paradigms, mental models, and mind-sets as religion-like phenomena. The author clarifies the meaning of the three phenomena to help readers to see how the phenomena become significant sources of resistance to change. He concludes by outlining a paradigm-shifting process to assist…

Extending the Boundaries of Debate Theory: A Value-Bounded Policy Decision Making Paradigm.

ERIC Educational Resources Information Center

Thomas, David A.; Corsi, Jerome R.

The purpose of this paper is to propose a new, synthetic paradigm for debate analysis and decision making that features the policy systems approach within a context of values as boundaries for decision. As background for the proposed theory, the paper (1) summarizes the notions of paradigm formation and shifts initially presented by T. Kuhn; (2)…

Response to Elvira Panaiotidi, "The Nature of Paradigms and Paradigm Shifts in Music Education"

ERIC Educational Resources Information Center

Rodriguez, Carlos Xavier

2005-01-01

Elvira Panaiotidi has delivered a very useful and appealing paper on the topic of how the music education community decides it is time to change the way it thinks and acts. Her primary focus is whether the concept of "paradigms" proposed by Thomas Kuhn in The Structure of Scientific Revolutions reasonably explains how change occurs in…

The 2014 ESPEN Arvid Wretlind Lecture: Metabolism & nutrition: Shifting paradigms in COPD management.

PubMed

Schols, Annemie M W J

2015-12-01

COPD is a chronic disease of the lungs, but heterogeneous with respect to clinical manifestations and disease progression. This has consequences for health risk assessment, stratification and management. Heterogeneity can be driven by pulmonary events but also by systemic consequences (e.g. cachexia and muscle weakness) and co-morbidity (e.g. osteoporosis, diabetes and cardiovascular disease). This paper shows how a metabolic perspective on COPD has contributed significantly to understanding clinical heterogeneity and the need for a paradigm shift from reactive medicine towards predictive, preventive, personalized and participatory medicine. These insights have also lead to a paradigm shift in nutritional therapy for COPD from initial ignorance or focusing on putative adverse effects of carbohydrate overload on the ventilatory system to beneficial effects of nutritional intervention on body composition and physical functioning as integral part of disease management. The wider implications beyond COPD as disease have been as clinical model for translational cachexia research. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Shifting the HIV training and research paradigm to address disparities in HIV outcomes

PubMed Central

LEVISON, Julie H.; ALEGRÍA, Margarita

2016-01-01

Tailored programs to diversify the pool of HIV/AIDS investigators and provide sufficient training and support for minority investigators to compete successfully are uncommon in the US and abroad. This paper encourages a shift in the HIV/AIDS training and research paradigm to effectively train and mentor Latino researchers in the US, Latin America and the Caribbean. We suggest three strategies to accomplish this: 1) coaching senior administrative and academic staff of HIV/AIDS training programs on the needs, values, and experiences unique to Latino investigators; 2) encouraging mentors to be receptive to a different set of research questions and approaches that Latino researchers offer due to their life experiences and perspectives; and 3) creating a virtual infrastructure to share resources and tackle challenges faced by minority researchers. Shifts in the research paradigm to include, retain, and promote Latino HIV/AIDS researchers will benefit the scientific process and the patients and communities who await the promise of HIV/AIDS research. PMID:27501811

The transition from animal spirits to animal electricity: a neuroscience paradigm shift.

PubMed

Clower, W T

1998-12-01

The Animal Spirits Paradigm had been in place for over a thousand years as a general way of looking at the nervous system, and was completely ingrained into the fabric of scientific thinking. However, the community of researchers in the 17th and 18th centuries abandoned their long-held assumptions, and started anew with the novel assertion that the currency of nervous function was, instead of Animal Spirits, a uniquely amimal electricity. This conceptual rearrangement represented a scientific revolution in thinking, a change in absolute perspective that required the reinterpretation of old data within a completely novel framework. The manner in which this transition occurred followed the general form of scientific paradigm shifts as outlined by Thomas Kuhn (Kuhn, 1962)

Attentional sensitivity and asymmetries of vertical saccade generation in monkey

NASA Technical Reports Server (NTRS)

Zhou, Wu; King, W. M.; Shelhamer, M. J. (Principal Investigator)

2002-01-01

The first goal of this study was to systematically document asymmetries in vertical saccade generation. We found that visually guided upward saccades have not only shorter latencies, but higher peak velocities, shorter durations and smaller errors. The second goal was to identify possible mechanisms underlying the asymmetry in vertical saccade latencies. Based on a recent model of saccade generation, three stages of saccade generation were investigated using specific behavioral paradigms: attention shift to a visual target (CUED paradigm), initiation of saccade generation (GAP paradigm) and release of the motor command to execute the saccade (DELAY paradigm). Our results suggest that initiation of a saccade (or "ocular disengagement") and its motor release contribute little to the asymmetry in vertical saccade latency. However, analysis of saccades made in the CUED paradigm indicated that it took less time to shift attention to a target in the upper visual field than to a target in the lower visual field. These data suggest that higher attentional sensitivity to targets in the upper visual field may contribute to shorter latencies of upward saccades.

Changing the paradigm of emergency response: The need for first-care providers.

PubMed

Bobko, Joshua P; Kamin, Richard

2015-01-01

There is a major gap in the security of the critical infrastructure - civilian medical response to atypical emergencies. Clear evidence demonstrates that, despite ongoing improvements to the first-responder system, there exists an inherent delay in the immediate medical care at the scene of an emergency. This delay can only be reduced through a societal shift in reliance on police and fire response and by extending the medical system into all communities. Additionally, through analysis of military data, it is known that immediately addressing the common injury patterns following a traumatic event will save lives. The predictable nature of these injuries, coupled with an unavoidable delay in the arrival of first responders, necessitates the need for immediate care on scene. Initial care is often rendered by bystanders, typically armed only with basic first-aid training based on medical emergencies and does not adequately address the traumatic injury patterns seen in disasters. Implementing an approach similar to the American Cardiac Arrest Act can improve outcomes to traumatic events. This paper analyses the latest data on active shooter incidents and proposes that the creation of a network of trauma-trained medic extenders would improve all communities' resilience to catastrophic disaster.

Biocompatibility: meeting a key functional requirement of next-generation medical devices.

PubMed

Helmus, Michael N; Gibbons, Donald F; Cebon, David

2008-01-01

The array of polymeric, biologic, metallic, and ceramic biomaterials will be reviewed with respect to their biocompatibility, which has traditionally been viewed as a requirement to develop a safe medical device. With the emergence of combination products, a paradigm shift is occurring that now requires biocompatibility to be designed into the device. In fact, next-generation medical devices will require enhanced biocompatibility by using, for example, pharmacological agents, bioactive coatings, nano-textures, or hybrid systems containing cells that control biologic interactions to have desirable biologic outcomes. The concept of biocompatibility is moving from a "do no harm" mission (i.e., nontoxic, nonantigenic, nonmutagenic, etc.) to one of doing "good," that is, encouraging positive healing responses. These new devices will promote the formation of normal healthy tissue as well as the integration of the device into adjacent tissue. In some contexts, biocompatibility can become a disruptive technology that can change therapeutic paradigms (e.g., drug-coated stents). New database tools to access biocompatibility data of the materials of construction in existing medical devices will facilitate the use of existing and new biomaterials for new medical device designs.

Need for Enhanced Environmental Representation in the Implementation of One Health.

PubMed

Barrett, Meredith A; Bouley, Timothy A

2015-06-01

Issues of global environmental change, global health, emerging disease, and sustainability present some of the most complex challenges of the twenty-first century. Individual disciplines cannot address these issues in isolation. Proactive, innovative, and trans-disciplinary solutions are required. Recognizing the inherent connectedness of humans, animals, plants, and their shared environment, One Health encourages the collaboration of many disciplines-including human and veterinary medicine, public health, social science, public policy, environmental science, and others-to address global and local health challenges. Despite great progress in this shift toward transdisciplinarity, the environmental component of the One Health paradigm remains underrepresented in One Health discourse. Human and animal health issues are commonly discussed under the umbrella of the One Health paradigm, while upstream environmental drivers and solutions are less prominent. We assessed the current integration of environmental issues in One Health publications and leadership. There is room for enhanced integration of environmental knowledge in the implementation of One Health approaches. We discuss the potential benefits from the collaboration between One Health and ecohealth, and explore strategies for increased environmental involvement.

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

PubMed Central

Miller, Jordan D.; Weiss, Robert M.; Heistad, Donald D.

2011-01-01

Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major paradigm shift in the field. CAVS was thought to be a passive, degenerative process, whereas now the progression of calcification in CAVS is considered to be actively regulated. Mechanistic studies examining the contributions of true ectopic osteogenesis, non-osseous calcification, and ectopic osteoblast-like cells (that appear to function differently from skeletal osteoblasts) to valvular dysfunction have been facilitated by the development of mouse models of CAVS. Recent studies also suggest that valvular fibrosis, as well as calcification, may play an important role in restricting cusp movement, and CAVS may be more appropriately viewed as a fibrocalcific disease. High resolution echocardiography and magnetic resonance imaging have emerged as useful tools for testing the efficacy of pharmacological and genetic interventions in vivo. Key studies in humans and animals are reviewed that have shaped current paradigms in the field of CAVS, and suggest promising future areas for research. PMID:21617136

Cough Hypersensitivity Syndrome: A Few More Steps Forward

PubMed Central

Song, Woo-Jung

2017-01-01

Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the underlying condition. Although it remains a theoretical construct, emerging evidence suggests that aberrant neurophysiology is the common etiology of this syndrome. Recent success in randomized clinical trials using a P2X3 receptor antagonist is the first major advance in the therapeutics of cough in the past 30 years; it at last provides a strategy for treating intractable cough as well as an invaluable tool for dissecting the mechanism underpinning cough hypersensitivity. Additionally, several cough measurement tools have been validated for use and will help assess the clinical relevance of cough in various underlying conditions. Along with this paradigm shift, our understanding of cough mechanisms has improved during the past decades, allowing us to continue to take more steps forward in the future. PMID:28677352

Probing the String Landscape

ScienceCinema

Dienes, Keith

2018-01-10

We are currently in the throes of a potentially huge paradigm shift in physics. Motivated by recent developments in string theory and the discovery of the so-called "string landscape", physicists are beginning to question the uniqueness of fundamental theories of physics and the methods by which such theories might be understood and investigated. In this colloquium, I will give a non-technical introduction to the nature of this paradigm shift and how it developed. I will also discuss some of the questions to which it has led, and the nature of the controversies it has spawned.

Policy Dispute and Paradigm Evaluation: A Response to Rowland.

ERIC Educational Resources Information Center

Lichtman, Allan J.; Rohrer, Daniel M.

1982-01-01

Responds to Rowland's article, (CS 705 841). Contends that policy systems analysis emerges as the only acceptable paradigm for competitive debate and that it satisfies the criteria for paradigm evaluation. (PD)

The Newtonian Mechanistic Paradigm, Special Education, and Contours of Alternatives: An Overview.

ERIC Educational Resources Information Center

Heshusius, Lous

1989-01-01

The article examines theoretical reorientations in special education away from the Newtonian mechanistic paradigm toward an emerging holistic paradigm. Recent literature is critiqued for renaming theories as paradigms, thereby providing an illusion of change while leaving fundamental mechanistic assumptions in place. (Author/DB)

A Survey of Current Trends in Master's Programs in Microelectronics

ERIC Educational Resources Information Center

Bozanic, Mladen; Sinha, Saurabh

2018-01-01

Contribution: This paper brings forward a paradigm shift in microelectronic and nanoelectronic engineering education. Background: An increasing number of universities are offering graduate-level electrical engineering degree programs with multi-disciplinary Master's-level specialization in microelectronics or nanoelectronics. The paradigm shift…

Supervising Knowledge Work.

ERIC Educational Resources Information Center

Duffy, Francis M.

This paper summarizes a new paradigm of instructional supervision, which shifts the focus on supervision from an examination of individual behavior to the improvement of work processes and social system components of the school district. The paradigm, called "Knowledge Work Supervision," helps teams of teachers and specially trained supervisors…

Sustainable intensification of agriculture for human prosperity and global sustainability.

PubMed

Rockström, Johan; Williams, John; Daily, Gretchen; Noble, Andrew; Matthews, Nathanial; Gordon, Line; Wetterstrand, Hanna; DeClerck, Fabrice; Shah, Mihir; Steduto, Pasquale; de Fraiture, Charlotte; Hatibu, Nuhu; Unver, Olcay; Bird, Jeremy; Sibanda, Lindiwe; Smith, Jimmy

2017-02-01

There is an ongoing debate on what constitutes sustainable intensification of agriculture (SIA). In this paper, we propose that a paradigm for sustainable intensification can be defined and translated into an operational framework for agricultural development. We argue that this paradigm must now be defined-at all scales-in the context of rapidly rising global environmental changes in the Anthropocene, while focusing on eradicating poverty and hunger and contributing to human wellbeing. The criteria and approach we propose, for a paradigm shift towards sustainable intensification of agriculture, integrates the dual and interdependent goals of using sustainable practices to meet rising human needs while contributing to resilience and sustainability of landscapes, the biosphere, and the Earth system. Both of these, in turn, are required to sustain the future viability of agriculture. This paradigm shift aims at repositioning world agriculture from its current role as the world's single largest driver of global environmental change, to becoming a key contributor of a global transition to a sustainable world within a safe operating space on Earth.

India's NCD strategy in the SDG era: are there early signs of a paradigm shift?

PubMed

Mondal, Shinjini; Van Belle, Sara

2018-04-25

The Sustainable Development Goals (SDGs) are seen in most corners as the embodiment of a more inclusive and holistic development approach, key to addressing the numerous and urgent challenges the world faces. In the health realm, a true SDG approach will require a five-fold paradigm shift according to Buse and Hawkes. This article explores whether early traces of this paradigm shift can already be witnessed in the Indian context, focusing on Non-Communicable Diseases (NCDs) more in particular. By now, NCDs make up a large health burden in India, both individually and on the health system. Inspired by an SDG vision, tackling NCDs will require a comprehensive approach rooted in preventive, curative and rehabilitative services. In India, some early momentum in this respect can already be witnessed, certainly in addressing the first two challenges identified by Buse and Hawkes, leadership and intersectoral coherence, and a shift from treatment to prevention. A central plan addressing health through an inter-sectoral approach has shaped the trajectory so far, moving away from silos to engagement with sectors beyond health. New guidelines addressing comprehensive primary healthcare propose a community outreach and preventive approach for NCDs. At a broader level, NCD prevention is also closely linked to tackling the so called "commercial determinants of health" and will require among others strong (central and state level) regulation, teaming up with global advocacy networks and capitalizing on global frameworks, where they exist. Strong political leadership will be indispensable for this, and is according to Buse and Hawkes closely linked to seeing health as a right and the government as accountable when it comes to providing for the right to health through its policies and actions. National stewardship will thus be key, via a more adaptive network governance structure with the central level coordinating with the state level to ensure implementation, while also engaging with other stakeholders, sectors, the private sector and civil society. As one can expect, networked governance, necessary for the battle against NCDs, is a work in progress in India. In sum, some of the early (paradigm shift) signs are encouraging, but by and large it is still too early to assess whether a real paradigm shift has taken place.

The path to a paradigm shift in hemodialysis.

PubMed

Hodge, Melville H

2010-01-01

About 1 out of 4 American conventional dialysis patients die in the first year and 3 out of 5 die within 5 years with no favorable trend in sight. Largely ignored in practice is the evidence accumulated over decades that longer, more frequent dialysis can immediately slash this grim result in half or more. Pierratos has called for a paradigm shift--a disruptive change--in dialysis practice from conventional treatment to daily nocturnal dialysis, performed at home, to realize this dramatic improvement. We examine here how such a paradigm shift might be brought about and suggest that changes in 3 perspectives must occur. First, new dialysis guidelines must be recast from the old goal of minimally adequate to a new goal of best possible. Second, the body of dialysis research must be interpreted through the lens of best possible patient survival and well being, and the near-impossibility of demonstrating dialysis survival advantage through randomized clinical trials must be acknowledged. Finally, dialysis modality must be seen as, most importantly, a survival and well-being choice, not merely a "Lifestyle" choice; hence, it must be the nondelegatable responsibility of the physician, not dialysis center personnel, to advise and prescribe. Many old perspectives, which might stand in the way of this sorely needed paradigm shift are also examined. These old perspectives make up a fabric of excuses that has delayed--and, if not discarded, will continue to delay--progress toward a survival and well-being outlook for dialysis patients just as favorable as might be achieved through kidney transplant.

Primary repair of the anterior cruciate ligament: A paradigm shift.

PubMed

van der List, Jelle P; DiFelice, Gregory S

2017-06-01

Over the last century, many surgical treatments have been developed in the orthopedic field, including treatments of anterior cruciate ligament (ACL) injuries. These treatments ideally evolve in a process of trial and error with prospective comparison of new treatments to the current treatment standard. However, these evolutions are sometimes not linear and periodically undergo paradigm shifts. In this article, we review the evolution of ACL treatment and explain how it underwent a paradigm shift. Open primary ACL repair was the most common treatment in the 1970s and 1980s, but because multiple studies noted deterioration of outcomes at mid-term follow-up, in addition to several randomized clinical trials (RCTs) that noted better outcomes following ACL reconstruction, the open primary repair technique was abandoned. At the end of the primary repair era, however, several studies showed that outcomes of open primary repair were good to excellent and did not deteriorate when this technique was selectively performed in patients with proximal ACL tears, whereas primary repair led to disappointing and unpredictable results in patients with mid-substance tears. Unfortunately, enrollment of patients in the aforementioned RCTs was already finished, ultimately leading to abandoning of open primary repair, despite the advantages of ligament preservation. In this review, we discuss (I) why the evolution of ACL treatment underwent a paradigm shift, (II) which factors may have played a role in this and (III) what the future role of arthroscopic primary ACL repair is in the evolution of ACL treatments. Copyright © 2016. Published by Elsevier Ltd.

Parity and the medicalization of addiction treatment.

PubMed

Roy, Ken; Miller, Michael

2010-06-01

Parity, the idea that insurance coverage for the treatment of addiction should be on a par with insurance coverage for the treatment of other medical illnesses, is not a new idea, but the path to achieving "real parity" has been a long, hard and complex journey. Action by Congress to pass major parity legislation in 2008 was a huge step forward, but does not mean that parity has been achieved. Parity has required a paradigm shift in the understanding of addiction as a biological illness: many developments of science and policy changes by professional organizations and governmental entities have contributed to that paradigm shift. Access to adequate treatment for patients must acknowledge the paradigm shift reflected in parity as it has evolved to the current point: that this biological illness is widespread, that it is important that it be treated effectively, that appropriate third party payment for physician-provided or physician-supervised addiction treatment is critical for addiction medicine to become a part of the mainstream of our nation's healthcare delivery system, and that medical specialty care provides the most effective and cost effective benefit to patients and therefore to our society.

Lifestyle physical activity in persons with multiple sclerosis: the new kid on the MS block.

PubMed

Motl, Robert W

2014-07-01

Supervised exercise training has substantial benefits for persons with multiple sclerosis (MS), yet 80% of those with MS do not meet recommended levels of moderate-to-vigorous physical activity (MVPA). This same problem persisted for decades in the general population of adults and prompted a paradigm shift away from "exercise training for fitness" toward "physical activity for health." The paradigm shift reflects a public health approach of promoting lifestyle physical activity through behavioral interventions that teach people the skills, techniques, and strategies based on established theories for modifying and self-regulating health behaviors. This paper describes: (a) the definitions of and difference between structured exercise training and lifestyle physical activity; (b) the importance and potential impact of the paradigm shift; (c) consequences of lifestyle physical activity in MS; and (d) behavioral interventions for changing lifestyle physical activity in MS. The paper introduces the "new kid on the MS block" with the hope that lifestyle physical activity might become an accepted partner alongside exercise training for inclusion in comprehensive MS care. © The Author(s) 2014.

Paradigm shift from self-assembly to commanded assembly of functional materials: recent examples in porphyrin/fullerene supramolecular systems

NASA Astrophysics Data System (ADS)

Li, Mao; Ishihara, Shinsuke; Ji, Qingmin; Akada, Misaho; Hill, Jonathan P.; Ariga, Katsuhiko

2012-10-01

Current nanotechnology based on top-down nanofabrication may encounter a variety of drawbacks in the near future so that development of alternative methods, including the so-called bottom-up approach, has attracted considerable attention. However, the bottom-up strategy, which often relies on spontaneous self-assembly, might be inefficient in the development of the requisite functional materials and systems. Therefore, assembly processes controlled by external stimuli might be a plausible strategy for the development of bottom-up nanotechnology. In this review, we demonstrate a paradigm shift from self-assembly to commanded assembly by describing several examples of assemblies of typical functional molecules, i.e. porphyrins and fullerenes. In the first section, we describe recent progress in the design and study of self-assembled and co-assembled supramolecular architectures of porphyrins and fullerenes. Then, we show examples of assembly induced by external stimuli. We emphasize the paradigm shift from self-assembly to commanded assembly by describing the recently developed electrochemical-coupling layer-by-layer (ECC-LbL) methodology.

Clinical governance in pre-hospital care.

PubMed Central

Robertson-Steel, I; Edwards, S; Gough, M

2001-01-01

This article seeks to discover and recognize the importance of clinical governance within a new and emerging quality National Health Service (NHS) system. It evaluates the present state of prehospital care and recommends how change, via clinical governance, can ensure a paradigm shift from its currently fragmented state to a seamless ongoing patient care episode. Furthermore, it identifies the drivers of a quality revolution, examines the monitoring and supervision of quality care, and evaluates the role of evidence-based practice. A frank and open view of immediate care doctors is presented, with recommendations to improve the quality of skill delivery and reduce the disparity that exists. Finally, it reviews the current problems with pre-hospital care and projects a future course for quality and patient care excellence. PMID:11383428

Paradigm shift in plant growth control.

PubMed

Körner, Christian

2015-06-01

For plants to grow they need resources and appropriate conditions that these resources are converted into biomass. While acknowledging the importance of co-drivers, the classical view is still that carbon, that is, photosynthetic CO2 uptake, ranks above any other drivers of plant growth. Hence, theory and modelling of growth traditionally is carbon centric. Here, I suggest that this view is not reflecting reality, but emerged from the availability of methods and process understanding at leaf level. In most cases, poorly understood processes of tissue formation and cell growth are governing carbon demand, and thus, CO2 uptake. Carbon can only be converted into biomass to the extent chemical elements other than carbon, temperature or cell turgor permit. Copyright © 2015. Published by Elsevier Ltd.

U.S. shale gas trends - economic and global implications

NASA Astrophysics Data System (ADS)

Murphy, T.

2016-09-01

Natural gas from shale has moved the U.S., and North America more broadly, to become one of the largest producers of the commodity worldwide. Large technological gains have allowed reservoirs of unconventional hydrocarbons to become commercially viable to extract and market. The addition of this growing supply into the global marketplace, has upended longstanding trading patterns, and created new economic outcomes worth noting. This paper will discuss the recent trends of shale energy development in the U.S., the impact it is having on domestic and international markets, and the implications as the world shifts to a new low carbon energy paradigm. It will cover changes in workforce, midstream build out, power generation trends, petrochemicals, and emerging LNG export capacities.

Direct Oral Anticoagulants: An Overview for the Interventional Radiologist

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Pradesh, E-mail: pradeshkumar@doctors.org.uk; Ravi, Rajeev, E-mail: rajeev.ravi@aintree.nhs.uk; Sundar, Gaurav, E-mail: gaurav.sundar@aintree.nhs.uk

The direct oral anticoagulants (DOACs) have emerged as a good alternative for the treatment of thromboembolic diseases, and their use in clinical practice is increasing rapidly. The DOACs act by blocking the activity of one single step in the coagulation cascade. These drugs act downstream in the common pathway of the coagulation cascade by directly antagonising the action of thrombin or factor Xa. The development of DOACs represents a paradigm shift from the oral vitamin K antagonists such as warfarin. This article aims to describe the properties of the currently available DOACs including pharmacology and dosing. We also address themore » strategies for periprocedural management and reversal of anticoagulation of patients treated with these agents.« less

Nurse faculty experiences in problem-based learning: an interpretive phenomenologic analysis.

PubMed

Paige, Jane B; Smith, Regina O

2013-01-01

This study explored the nurse faculty experience of participating in a problem-based learning (PBL) faculty development program. Utilizing PBL as a pedagogical method requires a paradigm shift in the way faculty think about teaching, learning, and the teacher-student relationship. An interpretive phenomenological analysis approach was used to explore the faculty experience in a PBL development program. Four themes emerged: change in perception of the teacher-student relationship, struggle in letting go, uncertainty, and valuing PBL as a developmental process. Epistemic doubt happens when action and intent toward the PBL teaching perspective do not match underlying beliefs. Findings from this study call for ongoing administrative support for education on PBL while faculty take time to uncover hidden epistemological beliefs.

Paradigm Shift or Annoying Distraction

PubMed Central

Spallek, H.; O’Donnell, J.; Clayton, M.; Anderson, P.; Krueger, A.

2010-01-01

Web 2.0 technologies, known as social media, social technologies or Web 2.0, have emerged into the mainstream. As they grow, these new technologies have the opportunity to influence the methods and procedures of many fields. This paper focuses on the clinical implications of the growing Web 2.0 technologies. Five developing trends are explored: information channels, augmented reality, location-based mobile social computing, virtual worlds and serious gaming, and collaborative research networks. Each trend is discussed based on their utilization and pattern of use by healthcare providers or healthcare organizations. In addition to explorative research for each trend, a vignette is presented which provides a future example of adoption. Lastly each trend lists several research challenge questions for applied clinical informatics. PMID:23616830

Supplementing the neurosurgical virtuoso: evolution of automation from mythology to operating room adjunct.

PubMed

Attenello, Frank J; Lee, Brian; Yu, Cheng; Liu, Charles Y; Apuzzo, Michael L J

2014-01-01

A central concept of scientific advancement in the medical and surgical fields is the incorporation of successful emerging ideas and technologies throughout the scope of human endeavors. The field of automation and robotics is a pivotal representation of this concept. Arising in the mythology of Homer, the concept of automation and robotics grew exponentially over the millennia to provide the substrate for a paradigm shift in the current and future practice of neurosurgery. We trace the growth of this field from the seminal concepts of Homer and Aristotle to early incorporation into neurosurgical practice. Resulting changes provide drastic and welcome advances in areas of visualization, haptics, acoustics, dexterity, tremor reduction, motion scaling, and surgical precision. Published by Elsevier Inc.

Inclusive Branding Strategies for Domestic Violence Agencies: Embracing Opportunities to Reach and Better Serve Male-Identified Survivors.

PubMed

Dewey, Morgan; Heiss, Sarah N

2018-05-01

Successful strategies for branding that are inclusive of male-identified survivors were identified in this qualitative study through semi-structured interviews with leaders from six domestic violence agencies across the United States: four represented traditional domestic violence agencies and two represented specialized agencies with expertise in providing services to nontraditional survivors. The strategic implementation of (a) inclusive language, (b) visual diversity, (c) community outreach, and (d) communication channels emerged as successful strategies in branding in an inclusive way for male-identified survivors. The implementation of these successful strategies provides the opportunity for domestic violence agencies to create an inclusive environment for male-identified survivors and would contribute to a paradigm shift in how domestic violence is viewed.

Toward a patient-based paradigm for blood transfusion.

PubMed

Farrugia, Albert; Vamvakas, Eleftherios

2014-01-01

The current "manufacturing paradigm" of transfusion practice has detached transfusion from the clinical environment. As an example, fresh whole blood in large-volume hemorrhage may be superior to whole blood reconstituted from multiple components. Multicomponent apheresis can overcome logistical difficulties in matching patient needs with fresh component availability and can deliver the benefits of fresh whole blood. Because of the different transfusion needs of patients in emerging economies and the vulnerability of these blood systems to emerging infections, fresh whole blood and multicomponent apheresis can better meet patient needs when compared with transplants of the "manufacturing paradigm". We propose that patient blood management, along with panels of repeat, paid, accredited apheresis and fresh whole-blood donors can be used in emerging economies to support decentralized blood services. This alternative transfusion-medicine paradigm could eventually also be adopted by established economies to focus transfusion medicine on local patient needs and to alleviate the problem of the aging volunteer donor base.

Shared Decision-Making as the Future of Emergency Cardiology.

PubMed

Probst, Marc A; Noseworthy, Peter A; Brito, Juan P; Hess, Erik P

2018-02-01

Shared decision-making is playing an increasingly large role in emergency cardiovascular care. Although there are many challenges to successfully performing shared decision-making in the emergency department, there are numerous clinical scenarios in which it should be used. In this article, we explore new research and emerging decision aids in the following emergency care scenarios: (1) low-risk chest pain; (2) new-onset atrial fibrillation; and (3) moderate-risk syncope. These decision aids are designed to engage patients and facilitate shared decision-making for specific treatment and disposition (admit vs discharge) decisions. We then offer a 3-step, practical approach to performing shared decision-making in the acute care setting, on the basis of broad stakeholder input and previous conceptual work. Step 1 involves simply acknowledging that a clinical decision needs to be made. Step 2 involves a shared discussion about the working diagnosis and the options for care in the context of the patient's values, preferences, and circumstances. The third and final step requires the patient and provider to agree on a plan of action regarding further medical care. The implementation of shared decision-making in emergency cardiology has the potential to shift the paradigm of clinical practice from paternalism toward mutualism and improve the quality and experience of care for our patients. Copyright © 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

The RMA and the Post Goldwater-Nichols World. More Tinkering Ahead for the JCS?

DTIC Science & Technology

1995-05-16

Congress?19 There is little debate on this issue today. Perhaps the locus for the most vicious inter-Service budgetary battles has simply shifted (as many... paradigm as the congressionally legislated system designed to insure proper use of public funds and distinguished this paradigm from the...entrepreneurial management paradigm designed to maximize profits in the private sector. Moe questioned the acceptance of similarity between management in the

A Bilingual Advantage in Task Switching

ERIC Educational Resources Information Center

Prior, Anat; MacWhinney, Brian

2010-01-01

This study investigated the possibility that lifelong bilingualism may lead to enhanced efficiency in the ability to shift between mental sets. We compared the performance of monolingual and fluent bilingual college students in a task-switching paradigm. Bilinguals incurred reduced switching costs in the task-switching paradigm when compared with…

International Handbook of Research on Conceptual Change

ERIC Educational Resources Information Center

Vosniadou, Stella

2008-01-01

The study of conceptual change traces its heritage to the notions of paradigm (networks of shared beliefs, concepts, practices) and paradigm shift made famous by Thomas Kuhn in his book, "The Structure of Scientific Revolutions". Kuhn's work was quickly linked to developmental psychology (how knowledge develops) and to science education (teaching…

Paradigms and Postmodernism in Science and Science Education.

ERIC Educational Resources Information Center

Pushkin, David B.

Science, particularly the physical sciences, has undergone several paradigm shifts during history. The modernistic and mechanistic world that was viewed through the lens of Newton's laws no longer offers valid answers to present-day questions. This paper examines four themes: the evolution of physics, the evolution of chemistry, the evolution of…

Translingual Practice as Spatial Repertoires: Expanding the Paradigm beyond Structuralist Orientations

ERIC Educational Resources Information Center

Canagarajah, Suresh

2018-01-01

The expanding orientations to translingualism are motivated by a gradual shift from the structuralist paradigm that has been treated as foundational in modern linguistics. Structuralism encouraged scholars to consider language, like other social constructs, as organized as a self-defining and closed structure, set apart from spatiotemporal…

The Limits of Pedagogy: "Diaculturalist Pedagogy" as Paradigm Shift in the Education of Adult Immigrants

ERIC Educational Resources Information Center

Entigar, Katherine E.

2017-01-01

Pedagogy develops through the interventions of scholars who believe injustice should not be normalised. Such interventions nonetheless subsume monoculturalist assumptions constructed within the US social and academic narrative. The top-down paradigm of "designing pedagogy" is inappropriate for educating adult immigrants, whose…

The Lunar Occultation Explorer (LOX): Establishing the Moon as a Platform for Next-Generation Nuclear Astrophysics Investigations

NASA Astrophysics Data System (ADS)

Miller, R. S.; Ajello, M.; Beacom, J. F.; Bloser, P. F.; Burrows, A.; Errando, M.; Goldsten, J. O.; Hartmann, D.; Hoeflich, P.; Hungerford, A.; Lawrence, D. J.; Leary, J. C.; Leising, M. D.; Milne, P.; Peplowski, P. N.; The, L.-S.

2018-02-01

The Lunar Occultation Explorer (LOX) is a paradigm shift that will leverage the power of a new observational paradigm to transform our understanding of the nuclear cosmos (0.1-10 MeV) and establish the Moon as a platform for astrophysics.

The Digital Twin Paradigm for Future NASA and U.S. Air Force Vehicles

NASA Technical Reports Server (NTRS)

Glaessgen, Edward H.; Stargel, D. S.

2012-01-01

Future generations of NASA and U.S. Air Force vehicles will require lighter mass while being subjected to higher loads and more extreme service conditions over longer time periods than the present generation. Current approaches for certification, fleet management and sustainment are largely based on statistical distributions of material properties, heuristic design philosophies, physical testing and assumed similitude between testing and operational conditions and will likely be unable to address these extreme requirements. To address the shortcomings of conventional approaches, a fundamental paradigm shift is needed. This paradigm shift, the Digital Twin, integrates ultra-high fidelity simulation with the vehicle s on-board integrated vehicle health management system, maintenance history and all available historical and fleet data to mirror the life of its flying twin and enable unprecedented levels of safety and reliability.

A Navajo Paradigm for Long Life Happiness--and for Reversing Navajo Language Shift.

ERIC Educational Resources Information Center

House, Deborah

1997-01-01

Describes a Navajo model by which individuals may assume responsibility for reversing Navajo language shift. Argues that reversing Navajo language shift requires that Navajos acknowledge the problem, that Navajo principles of balance and the natural order be applied to the problem, and that Navajo individuals and families make a commitment to…

Teaching Note--Integrating Prevention Content into Clinical Social Work Practice Courses

ERIC Educational Resources Information Center

Rishel, Carrie W.

2014-01-01

Rapid changes in health care services and delivery suggest an upcoming paradigm shift in the field of mental health. Recent national reports, health care policy changes, and growing evidence support a shift toward prevention-focused mental health care. The social work profession is uniquely positioned to act as leaders in this shift as the…

The paradigm shift to an "open" model in drug development.

PubMed

Au, Regina

2014-12-01

The rising cost of healthcare, the rising cost for drug development, the patent cliff for Big pharma, shorter patent protection, decrease reimbursement, and the recession have made it more difficult for the pharmaceutical and biotechnology industry to develop drugs. Due to the unsustainable amount of time and money in developing a drug that will have a significant return on investment (ROI) it has become hard to sustain a robust pipeline. The industry is transforming its business model to meet these challenges. In essence a paradigm shift is occurring; the old "closed" model is giving way to a new "open" business model.

The Winds of Change: Thomas Kuhn and the Revolution in the Teaching of Writing.

ERIC Educational Resources Information Center

Hairston, Maxine

1982-01-01

Uses Thomas Kuhn's hypothesis on paradigm shifts--changes in a discipline from established models to newer ones--to examine the developing shift in writing instruction from the product-oriented to the process-oriented model. (RL)

Social Studies and Emerging Paradigms: Artificial Intelligence and Consciousness Education.

ERIC Educational Resources Information Center

Braun, Joseph A., Jr.

1987-01-01

Asks three questions: (1) Are machines capable of thinking as people do? (2) How is the thinking of computers similar and different from human thinking? and (3) What exactly is thinking? Examines research in artificial intelligence. Describes the theory and research of consciousness education and discusses an emerging paradigm for human thinking…

Education Student Research Paradigms and Emerging Scholar Identities: A Mixed-Methods Study

ERIC Educational Resources Information Center

Hales, Patrick D.; Croxton, Rebecca A.; Kirkman, Christopher J.

2016-01-01

Using a mixed-methods approach, this study sought to understand a general sense of paradigm confidence and to see how this confidence relates to doctoral student identities as emerging scholars. Identity development was explored among 46 education doctoral students at a midsized public university in the Southeast. Researchers examined students'…

Changing the Cultural Paradigm to Meet Emerging Requirements

NASA Technical Reports Server (NTRS)

Robbins, William W.

2007-01-01

This viewgraph presentation reviews changes that are required in Space Transportation. This new transportation paradigm from the reliance on the Space Shuttle to a mixture of space transportation vehicles, i.e., the Russian Progress, vehicle, the Japanese HTV, the European ATV and other commercial orbital transportation systems, requires a new cultural paradigm. This new paradigm is outlined, and reviewed.

Network synchronization in hippocampal neurons.

PubMed

Penn, Yaron; Segal, Menahem; Moses, Elisha

2016-03-22

Oscillatory activity is widespread in dynamic neuronal networks. The main paradigm for the origin of periodicity consists of specialized pacemaking elements that synchronize and drive the rest of the network; however, other models exist. Here, we studied the spontaneous emergence of synchronized periodic bursting in a network of cultured dissociated neurons from rat hippocampus and cortex. Surprisingly, about 60% of all active neurons were self-sustained oscillators when disconnected, each with its own natural frequency. The individual neuron's tendency to oscillate and the corresponding oscillation frequency are controlled by its excitability. The single neuron intrinsic oscillations were blocked by riluzole, and are thus dependent on persistent sodium leak currents. Upon a gradual retrieval of connectivity, the synchrony evolves: Loose synchrony appears already at weak connectivity, with the oscillators converging to one common oscillation frequency, yet shifted in phase across the population. Further strengthening of the connectivity causes a reduction in the mean phase shifts until zero-lag is achieved, manifested by synchronous periodic network bursts. Interestingly, the frequency of network bursting matches the average of the intrinsic frequencies. Overall, the network behaves like other universal systems, where order emerges spontaneously by entrainment of independent rhythmic units. Although simplified with respect to circuitry in the brain, our results attribute a basic functional role for intrinsic single neuron excitability mechanisms in driving the network's activity and dynamics, contributing to our understanding of developing neural circuits.

Critical Review--Outsourcing: A Paradigm Shift.

ERIC Educational Resources Information Center

Kakabadse, Nada; Kakabadse, Andrew

2000-01-01

Discusses trends in outsourcing, provision of goods and services to an organization that were previously delivered in house. Addresses outsourcing in the public sector, advantages and disadvantages, implications for human resource development, and the shift to the new "psychological contract" between employers and employees. (Contains…

A paradigm shift to enable more cost-effective space science telescope missions in the upcoming decades

NASA Astrophysics Data System (ADS)

Matthews, Gary; Havey, Keith, Jr.; Egerman, Robert

2010-07-01

Modern astronomy currently is dealing with an exciting but challenging dichotomy. On one hand, there has been and will continue to be countless advances in scientific discovery, but on the other the astronomical community is faced with what unfortunately is considered by many to be an insurmountable budgetary impasse for the foreseeable future. The National Academy of Sciences' Astro2010: Decadal Survey has been faced with the difficult challenge of prioritizing sciences and missions for the upcoming decade while still allowing room for new, yet to be discovered opportunities to receive funding. To this end, we propose the consideration of a paradigm shift to the astronomical community that may enable more cost efficient space-based telescope missions to be funded and still provide a high science return per dollar invested. The proposed paradigm shift has several aspects that make it worthy of consideration: 1) Telescopes would leverage existing Commercial Remote Sensing Satellite (CRSS) Architectures such as the 1.1m NextView systems developed by ITT, GeoEye-1, and WorldView-2, or the 0.7m IKONOS system (or perhaps other proprietary systems); 2) By using large EELV class fairings, multiple telescopes with different science missions could be flown on a single spacecraft bus sharing common features such as communications and telemetry (current Earth Science missions in early development phases are considering this approach); 3) Multiple smaller observatories (with multiple spacecraft) could be flown in a single launch vehicle for instances where the different science payloads had incompatible requirements; and 4) by leveraging CRSS architectures, vendors could supply telescopes at a fixed price. Here we discuss the implications and risks that the proposed paradigm shift would carry.

Search and Discovery Strategies for Biotechnology: the Paradigm Shift

PubMed Central

Bull, Alan T.; Ward, Alan C.; Goodfellow, Michael

2000-01-01

Profound changes are occurring in the strategies that biotechnology-based industries are deploying in the search for exploitable biology and to discover new products and develop new or improved processes. The advances that have been made in the past decade in areas such as combinatorial chemistry, combinatorial biosynthesis, metabolic pathway engineering, gene shuffling, and directed evolution of proteins have caused some companies to consider withdrawing from natural product screening. In this review we examine the paradigm shift from traditional biology to bioinformatics that is revolutionizing exploitable biology. We conclude that the reinvigorated means of detecting novel organisms, novel chemical structures, and novel biocatalytic activities will ensure that natural products will continue to be a primary resource for biotechnology. The paradigm shift has been driven by a convergence of complementary technologies, exemplified by DNA sequencing and amplification, genome sequencing and annotation, proteome analysis, and phenotypic inventorying, resulting in the establishment of huge databases that can be mined in order to generate useful knowledge such as the identity and characterization of organisms and the identity of biotechnology targets. Concurrently there have been major advances in understanding the extent of microbial diversity, how uncultured organisms might be grown, and how expression of the metabolic potential of microorganisms can be maximized. The integration of information from complementary databases presents a significant challenge. Such integration should facilitate answers to complex questions involving sequence, biochemical, physiological, taxonomic, and ecological information of the sort posed in exploitable biology. The paradigm shift which we discuss is not absolute in the sense that it will replace established microbiology; rather, it reinforces our view that innovative microbiology is essential for releasing the potential of microbial diversity for biotechnology penetration throughout industry. Various of these issues are considered with reference to deep-sea microbiology and biotechnology. PMID:10974127

Going Rogue in the Spatial Cuing Paradigm: High Spatial Validity Is Insufficient to Elicit Voluntary Shifts of Attention

ERIC Educational Resources Information Center

Davis, Gregory J.; Gibson, Bradley S.

2012-01-01

Voluntary shifts of attention are often motivated in experimental contexts by using well-known symbols that accurately predict the direction of targets. The authors report 3 experiments, which showed that the presentation of predictive spatial information does not provide sufficient incentive to elicit voluntary shifts of attention. For instance,…

Shiftwork: A Chaos Theory of Careers Agenda for Change in Career Counseling

ERIC Educational Resources Information Center

Bright, Jim E. H.; Pryor, Robert G. L.

2008-01-01

This paper presents the implications of the Chaos Theory of Careers for career counselling in the form of Shiftwork. Shiftwork represents an expanded paradigm of career counselling based on complexity, change and uncertainty. Eleven paradigm shifts for careers counselling are outlined to incorporate into contemporary practice pattern making, an…

Learning for Understanding: A Faculty-Driven Paradigm Shift in Learning, Imaginative Teaching, and Creative Assessment

ERIC Educational Resources Information Center

Diaz-Lefebvre, Rene

2006-01-01

This article describes an experimental pilot study begun in 1994 in the Glendale Community College (Glendale, Arizona) psychology department. The faculty-driven idea incorporated Howard Gardner's multiple intelligences theory (MI) into a new paradigm--one where creative forms of learning resulted in real understanding. The pilot study, Multiple…

School on Cloud: Towards a Paradigm Shift

ERIC Educational Resources Information Center

Koutsopoulos, Kostis C.; Kotsanis, Yannis C.

2014-01-01

This paper presents the basic concept of the EU Network School on Cloud: Namely, that present conditions require a new teaching and learning paradigm based on the integrated dimension of education, when considering the use of cloud computing. In other words, it is suggested that there is a need for an integrated approach which is simultaneously…

Considerations of the Actiotope Model of Giftedness

ERIC Educational Resources Information Center

Cohen, Libby

2012-01-01

As Ziegler and Phillipson discussed in their article "Towards a systemic theory of gifted education," various paradigms, models and theories have been described in the extensive literature on giftedness. According to Ziegler and Phillipson, there is a pressing need for new models of giftedness--they call for a paradigm shift. The actiotope model…

Knowledge of the Debate Critic-Judge.

ERIC Educational Resources Information Center

Phillips, Neil

Arguing that any discussion of debate theory is incomplete without at least some analysis or review of paradigm theory, this paper begins by analogizing the arguments over paradigms to a battle ground over control of the activity. The analysis then shifts to an examination of Thomas Kuhn's sociological theory as a basis for the argument that the…

The Emerging Paradigm in Probation and Parole in the United States

ERIC Educational Resources Information Center

Kimora

2008-01-01

There is an emerging paradigm in probation and parole in the United States. That new outlook encompasses a realization that these forms of supervision of offenders must meet the challenges of an increasing number of parolees and probationers. Recidivism continues to be the primary outcome measure for probation, as it is for all corrections…

Environmental dilemma game to establish a sustainable society dealing with an emergent value system

NASA Astrophysics Data System (ADS)

Tanimoto, Jun

2005-01-01

To induce whether we can obtain a sustainable society by shifting our paradigm from the materialistic to the eco-conscientious, we established a multi-agent simulation model. The model primarily featured a dilemma structure encouraged by a conflict between each agent's private desire to earn more and the need for environmental conservation. Another important feature is that the model has two evolutionary layers. The subordinate layer is a learning system comprised of a finite state machine (FSM) and a genetic algorithm (GA) primarily, which is carried with each individual agent to determine his/her next behavior and how much he/she must earn to maximize an individual fitness function. The supra layer is the so-called value system, the gene pool of which is shared within the society. The value system stipulates an agent's fitness function, which in turn affects the agent's behavior. The value system of each agent was set up to be entirely ego-oriented at the beginning of the simulation episode. A numerical experiment based on the model reveals a scene in which, under a certain condition related to assumptions of the value system, a group of agents undergoes a paradigm shift from the ego-oriented materialism to the eco-conscious sustainable society. The key condition is a latent existence of several values that ultimately lead to sustainability, even though they do not work at all at the beginning of the episode. In terms of the evolutionary game theory, this implies that changing game structure on the way of a simulation episode by transforming the fitness function seems to be much powerful measures for the emergent collective cooperation among the agents than ordinal options to support cooperation. In addition, we made a detailed analysis on how assumed agents have obtained a sustainable value system. Each agent has an individual decision-making process based on the input with a learning mechanism. We focus here on two types of learning system, the finite state machine (FSM) plus genetic algorithm (GA), and profit shearing (PS). Observation of the generative trails of FSM and the value table of PS lead us to a profound understanding of what kind of inception triggers the emergence of a sustainable society.

Nurse/physician communication through a sensemaking lens: shifting the paradigm to improve patient safety.

PubMed

Manojlovich, Milisa

2010-11-01

Physician-nurse communication has been identified as one of the main obstacles to progress in patient safety. Breakdowns in communication between physicians and nurses often result in errors, many of which are preventable. Recent research into nurse/physician communication has borrowed heavily from team literature, tending to study communication as one behavior in a larger cluster of behaviors. The multicluster approach to team research has not provided enough analysis of and attention to communication alone. Research into communication specifically is needed to understand its crucial role in teamwork and safety. A critique of the research literature on nurse/physician communication published since 1992 revealed 3 dominant themes: settings and context, consensus building, and conflict resolution. A fourth implicit theme, the temporal nature of communication, emerged as well. These themes were used to frame a discussion on sensemaking: an iterative process arising from dialogue when 2 or more people share their unique perspectives. As a theoretical model, sensemaking may offer an alternative lens through which to view the phenomenon of nurse/physician communication and advance our understanding of how nurse/physician communication can promote patient safety. Sensemaking may represent a paradigm shift with the potential to affect 2 spheres of influence: clinical practice and health care outcomes. Sensemaking may also hold promise as an intervention because through sensemaking consensus may be built and errors possibly prevented. Engaging in sensemaking may overcome communication barriers without realigning power bases, incorporate contextual influences without drawing attention away from communicators, and inform actions arising from communication.

Emergency strategies and trends in the management of liver trauma.

PubMed

Jiang, Hongchi; Wang, Jizhou

2012-09-01

The liver is the most frequently injured organ during abdominal trauma. The management of hepatic trauma has undergone a paradigm shift over the past several decades, with mandatory operation giving way to nonoperative treatment. Better understanding of the mechanisms and grade of liver injury aids in the initial assessment and establishment of a management strategy. Hemodynamically unstable patients should undergo focused abdominal sonography for trauma, whereas stable patients may undergo computed tomography, the standard examination protocol. The grade of liver injury alone does not accurately predict the need for operation, and nonoperative management is rapidly becoming popular for high-grade injuries. Hemodynamic instability with positive focused abdominal sonography for trauma and peritonitis is an indicator of the need for emergent operative intervention. The damage control concept is appropriate for the treatment of major liver injuries and is associated with significant survival advantages compared with traditional prolonged surgical techniques. Although surgical intervention for hepatic trauma is not as common now as it was in the past, current trauma surgeons should be familiar with the emergency surgical skills necessary to manage complex hepatic injuries, such as packing, Pringle maneuver, selective vessel ligation, resectional debridement, and parenchymal sutures. The present review presents emergency strategies and trends in the management of liver trauma.

[Assistance to the climacteric woman: new paradigms].

PubMed

Lorenzi, Dino Roberto Soares De; Catan, Lenita Binelli; Moreira, Karen; Artico, Graziela Rech

2009-01-01

Population aging is a demographic reality for Brazil. Consequently, in the next years it is expected a progressive increase in seeking health care services in the country by women with complaints related to climacterium. Parallel to it, assistance at this part of woman's life has been going through a paradigm shift which has imposed to health professionals a change of attitude in relation to this stage of woman's life. Today it is acknowledged that the climacterium is influenced by biological, psychosocial and cultural factors, whose knowledge is fundamental for planning a more qualified and humanized care. This article proposes a reflection on the paradigm shifts in assistance at climacterium, highlighting important aspects as multidisciplinarity and interdisciplinarity, so as to serve better this portion of population, and provide it with more integrated and individualized care, bringing together knowledge and sensitivity, and always aiming at a better quality of life.

Making value a priority: how this paradigm shift is changing the landscape in health care.

PubMed

Kimberly, John; Cronk, Imran

2016-10-01

The world of health care is changing dramatically, as reflected in the number, magnitude, and scope of innovative new approaches-to how illness is treated and how better health is promoted-that are being implemented around the globe. The changes triggered by these initiatives affect both how care is organized, managed, and paid for and the kinds of approaches that are being developed to keep people healthy. Underlying these changes is a more fundamental paradigm shift, a shift in the priority given to "value" in the formulation of policy and management practice. This brief essay highlights five trends that are central in this shift: increasing emphasis on health promotion, movement toward value-based payment, advances in digital/mobile technology, exploitation of big data, and changes in support for biomedical research. Each of these has its own value controversies, and the individual impact of each is impossible to predict. Collectively, however, their impact is likely to be significant. © 2016 New York Academy of Sciences.

Introducing first year students to interprofessionalism: Exploring professional identity in the "enterprise culture": a Foucauldian analysis.

PubMed

DeMatteo, Dale J; Reeves, Scott

2013-01-01

This paper explores the experiences of, and thoughts on, interprofessional learning and care of first year health science students at a large Canadian university within a broad socioeconomic context. We apply discourse analysis to survey data collected to evaluate an introductory interprofessional event involving first year students from a variety of health professions. Follow-up focus-group interviews were conducted to gain greater understanding of student issues and concerns emerging from the survey, providing a second source of data. A significant paper entitled, "Education, enterprise culture and the entrepreneurial self: A Foucauldian perspective" by Peters (2001) provides an historical and theoretical framework for this paper. Peters notes the changing nature of professionalism and global crises in public institutions under neoliberalism as governments divest themselves of social responsibility, shifting it onto individuals through increased privatization and focus on entrepreneurialism. In exploring the thoughts and experiences of students through the historical lens of a shifting professional discourse and changing cultural and political environment, a unique view of professionalism and this interprofessional project comes to light. Reflective of the paradigm shift that Peters documents, there was evidence of students "internalizing" responsibility for a sustainable health care system through acquisition of interprofessional knowledge and behaviours.

The Role of Gut Microflora and the Cholinergic Anti-inflammatory Neuroendocrine System in Diabetes Mellitus

PubMed Central

Parekh, Parth J.; Nayi, Vipul R.; Johnson, David A.; Vinik, Aaron I.

2016-01-01

The obesity epidemic has drastically impacted the state of health care in the United States. Paralleling this epidemic is the incidence of diabetes mellitus, with a notable shift toward a much younger age of onset. While central to the pathogenesis of diabetes associated with obesity is the role of inflammation attributed to “adiposopathy.” Emerging data suggest that changes in sympathetic/parasympathetic balance regulated by the brain precede changes in the inflammatory cascade. It has now been established that the gut microflora contributes significantly to the activation and inhibition of autonomic control and impact the set of the neuroinflammatory inhibitory reflex mediated by the cholinergic nervous system. There has been a paradigm shift toward further investigating commensal bacteria in the pathogenesis of obesity and diabetes mellitus and its complications, as dysbiosis is thought to play a pivotal role in diabetic-associated disorders. This paper is intended to evaluate the role of intestinal dysbiosis in the pathogenesis of diabetes mellitus and examine the potential for restoration of balance via use of probiotics. PMID:27375553

Network analysis for a network disorder: The emerging role of graph theory in the study of epilepsy.

PubMed

Bernhardt, Boris C; Bonilha, Leonardo; Gross, Donald W

2015-09-01

Recent years have witnessed a paradigm shift in the study and conceptualization of epilepsy, which is increasingly understood as a network-level disorder. An emblematic case is temporal lobe epilepsy (TLE), the most common drug-resistant epilepsy that is electroclinically defined as a focal epilepsy and pathologically associated with hippocampal sclerosis. In this review, we will summarize histopathological, electrophysiological, and neuroimaging evidence supporting the concept that the substrate of TLE is not limited to the hippocampus alone, but rather is broadly distributed across multiple brain regions and interconnecting white matter pathways. We will introduce basic concepts of graph theory, a formalism to quantify topological properties of complex systems that has recently been widely applied to study networks derived from brain imaging and electrophysiology. We will discuss converging graph theoretical evidence indicating that networks in TLE show marked shifts in their overall topology, providing insight into the neurobiology of TLE as a network-level disorder. Our review will conclude by discussing methodological challenges and future clinical applications of this powerful analytical approach. Copyright © 2015 Elsevier Inc. All rights reserved.

Reexamining Fourth Generation War as a Paradigm for Future War

DTIC Science & Technology

2014-12-04

Kuhn’s theory, a paradigm shift in science has far-reaching effects on the broader world . 4GW theorists embrace this aspect of Kuhn’s “paradigm...with the perplexing and hostile challenges of the chaotic post-Cold War world for which the ‘rules’ have not yet been written. The three-block war...events within its framework. In short, it was ready-made for military officers seeking a unifying frame for understanding the world and their experiences

Animal models for probing the developmental basis of disease and dysfunction paradigm.

PubMed

Heindel, Jerrold J

2008-02-01

There is a major paradigm shift taking place in science that while simple is profound. The new paradigm suggests that susceptibility to disease is set in utero or neonatally as a result of the influences of nutrition and exposures to environmental stressors/toxicants. In utero nutrition and/or in utero or neonatal exposures to environmental toxicants alter susceptibility to disease later in life as a result of their ability to affect the programming of tissue function that occurs during development. This concept, which is still a hypothesis undergoing scientific testing and scrutiny, is called the developmental basis of health and disease. If true, then it says that the focus on disease prevention and intervention must change from the time of disease onset to perhaps decades prior: during the in utero and neonatal period. Perhaps the reason it has been so difficult to link environmental exposure to disease susceptibility is that scientists have been looking at the wrong time! Certainly, not all exposures that result in increased disease or dysfunction occur during development. This paradigm shift just suggests that this is a sensitive window of exposure that should be examined more thoroughly. This overview focuses on animal models for the assessment of this new scientific paradigm and the animal data that now supports it.

Converging Paradigms: A Reflection on Parallel Theoretical Developments in Psychoanalytic Metapsychology and Empirical Dream Research.

PubMed

Schmelowszky, Ágoston

2016-08-01

In the last decades one can perceive a striking parallelism between the shifting perspective of leading representatives of empirical dream research concerning their conceptualization of dreaming and the paradigm shift within clinically based psychoanalytic metapsychology with respect to its theory on the significance of dreaming. In metapsychology, dreaming becomes more and more a central metaphor of mental functioning in general. The theories of Klein, Bion, and Matte-Blanco can be considered as milestones of this paradigm shift. In empirical dream research, the competing theories of Hobson and of Solms respectively argued for and against the meaningfulness of the dream-work in the functioning of the mind. In the meantime, empirical data coming from various sources seemed to prove the significance of dream consciousness for the development and maintenance of adaptive waking consciousness. Metapsychological speculations and hypotheses based on empirical research data seem to point in the same direction, promising for contemporary psychoanalytic practice a more secure theoretical base. In this paper the author brings together these diverse theoretical developments and presents conclusions regarding psychoanalytic theory and technique, as well as proposing an outline of an empirical research plan for testing the specificity of psychoanalysis in developing dream formation.

Toward a functional analysis of the basal ganglia.

PubMed

Hayes, A E; Davidson, M C; Keele, S W; Rafal, R D

1998-03-01

Parkinson patients were tested in two paradigms to test the hypothesis that the basal ganglia are involved in the shifting of attentional set. Set shifting means a respecification of the conditions that regulate responding, a process sometimes referred to as an executive process. In one paradigm, upon the appearance of each stimulus, subjects were instructed to respond either to its color or to its shape. In a second paradigm, subjects learned to produce short sequences of three keypresses in response to two arbitrary stimuli. Reaction times were compared for the cases where set either remained the same or changed for two successive stimuli. Parkinson patients were slow to change set compared to controls. Parkinson patients were also less able to filter the competing but irrelevant set than were control subjects. The switching deficit appears to be dopamine based; the magnitude of the shifting deficit was related to the degree to which 1-dopa-based medication ameliorated patients' motor symptoms. Moreover, temporary withholding of medication, a so-called off manipulation, increased the time to switch. Using the framework of equilibrium point theory of movement, we discuss how a set switching deficit may also underlie clinical motor disturbances seen in Parkinson's disease.

[Botulinum toxin: from drug to poison].

PubMed

Dressler, D; Saberi, F A

2009-08-01

For most of its time, the history of botulinum toxin (BT) has been the history of botulism, i. e. of an intoxication with BT. By the end of the 1960's a paradigm shift took place which in this radicalness had never occurred before in the history of mankind. At that time BT was first used therapeutically to treat strabismus. From ophthalmology BT rapidly spread into numerous medical specialties. For most of its indications BT is the therapy of choice, for some it has revolutionized their treatment altogether. The widespread therapeutic use of BT allowed detailed clinical and technical investigations of BT's action upon the human body. Applying this knowledge we diagnosed for the first time chronic botulism in adults living on a farm with chronic bovine botulism. This constitutes another radical paradigm shift. The history of BT is the history of a dual paradigm shift each time induced by a complete reversal of the viewing perspective. Knowledge gain can be a linear process. It can, however, also be a circular one. Changes of the viewing perspective are crucial. Changing the viewing perspective may facilitate knowledge gain. This might be used to develop an instrument to facilitate knowledge gain. (c) Georg Thieme Verlag KG Stuttgart-New York.

The old care paradigm is dead, long live the new sustainable care paradigm: how can GP commissioning consortia meet the demand challenges of 21st century healthcare?

PubMed

Mackenzie, James

2011-07-01

There are many challenges facing the health system in the 21st century - the majority of which are related to managing demand for health services. To meet these challenges emerging GP commissioning consortia will need to take a new approach to commissioning health services - an approach that moves beyond the current acute-centred curative paradigm of care to a new sustainable paradigm of care that focuses on primary care, integrated services and upstream prevention to manage demand. A key part of this shift is the recognition that the health system does not operate in a vacuum and that strategic commissioning decisions must take account of wider determinants of health and well-being, and operate within the finite limits of the planet's natural resources. The sustainable development principle of balancing financial, social and environmental considerations is crucial in managing demand for health services and ensuring that the health system is resilient to risks of resource uncertainty and a changing climate. Building sustainability into the governance and contracting processes of GP commissioning consortia will help deliver efficiency savings, impact on system productivity, manage system risk and help manage demand through the health co-benefits of taking a whole systems approach to commissioning decisions. Commissioning services from providers committed to corporate social responsibility and sustainable business practices allows us to move beyond a health system that cures people reactively to one in which the health of individuals and populations is managed proactively through prevention and education. The opportunity to build sustainability principles into the culture of GP commissioning consortia upfront should be seized now to ensure the new model of commissioning endures and is fit for the future.

The old care paradigm is dead, long live the new sustainable care paradigm: how can GP commissioning consortia meet the demand challenges of 21st century healthcare?

PubMed Central

2011-01-01

There are many challenges facing the health system in the 21st century – the majority of which are related to managing demand for health services. To meet these challenges emerging GP commissioning consortia will need to take a new approach to commissioning health services – an approach that moves beyond the current acute-centred curative paradigm of care to a new sustainable paradigm of care that focuses on primary care, integrated services and upstream prevention to manage demand. A key part of this shift is the recognition that the health system does not operate in a vacuum and that strategic commissioning decisions must take account of wider determinants of health and well-being, and operate within the finite limits of the planet's natural resources. The sustainable development principle of balancing financial, social and environmental considerations is crucial in managing demand for health services and ensuring that the health system is resilient to risks of resource uncertainty and a changing climate. Building sustainability into the governance and contracting processes of GP commissioning consortia will help deliver efficiency savings, impact on system productivity, manage system risk and help manage demand through the health co-benefits of taking a whole systems approach to commissioning decisions. Commissioning services from providers committed to corporate social responsibility and sustainable business practices allows us to move beyond a health system that cures people reactively to one in which the health of individuals and populations is managed proactively through prevention and education. The opportunity to build sustainability principles into the culture of GP commissioning consortia upfront should be seized now to ensure the new model of commissioning endures and is fit for the future. PMID:25949650

The roles of stimulus repetition and hemispheric activation in visual half-field asymmetries.

PubMed

Sullivan, K F; McKeever, W F

1985-10-01

Hardyck, Tzeng, and Wang (1978, Brain and Language, 5, 56-71) hypothesized that ample repetition of a small number of stimuli is required in order to obtain VHF differences in tachistoscopic tasks. Four experiments, with varied levels of repetition, were conducted to test this hypothesis. Three experiments utilized the general task of object-picture naming and one utilized a word-naming task. Naming latencies constituted the dependent measure. The results demonstrate that for the object-naming paradigm repetition is required for RVF superiority to emerge. Repetition was found to be unnecessary for RVF superiority in the word-naming paradigm, with repetition actually reducing RVF superiority. Experiment I suggested the possibility that RVF superiority developed for the second half of the trials as a function of practice or hemispheric activation, regardless of repetition level. Subsequent experiments, better designed to assess this possibility, clearly refuted it. It was concluded that the effect of repetition depends on the processing requirements of the task. We propose that, for tasks which can be processed efficiently by one hemisphere, the effect of repetition will be to reduce VHF asymmetries; but tasks requiring substantial processing by both hemispheres will show shifts to RVF superiority as a function of repetition.

Recovery in Canada: Toward social equality

PubMed Central

PIAT, MYRA; SABETTI, JUDITH

2016-01-01

This article reviews evolution of the recovery paradigm in Canadian mental health. We first trace the origins and development of the recovery concept through the literature, followed by an examination of how the recovery concept has been implemented in national and provincial mental health policy since publication of the 2006 Kirby Commission Report. Based on consultations with Canadian policymakers, and an examination of available policy documents, we explore how the dual theme of ‘recovery’ and ‘well-being’, adopted by the Mental Health Commission of Canada in its 2009 strategy: Toward Recovery and Well-being - A Framework For a Mental Health Strategy has subsequently played out in mental health policymaking at the provincial level. Findings reveal mixed support for recovery as a guiding principle for mental health reform in Canada. While policies in some provinces reflect widespread support for recovery, and strong identification with the aspirations of the consumer movement; other provinces have shifted to population-based, wellness paradigms that privilege evidence-based services and professional expertise. The recognition of social equality for people who experience mental illness emerges as an important value in Canadian mental health policy, cutting across the conceptual divide between recovery and well-being. PMID:22385423

Coordination Dynamics in Cognitive Neuroscience

PubMed Central

Bressler, Steven L.; Kelso, J. A. Scott

2016-01-01

Many researchers and clinicians in cognitive neuroscience hold to a modular view of cognitive function in which the cerebral cortex operates by the activation of areas with circumscribed elementary cognitive functions. Yet an ongoing paradigm shift to a dynamic network perspective is underway. This new viewpoint treats cortical function as arising from the coordination dynamics within and between cortical regions. Cortical coordination dynamics arises due to the unidirectional influences imposed on a cortical area by inputs from other areas that project to it, combined with the projection reciprocity that characterizes cortical connectivity and gives rise to reentrant processing. As a result, cortical dynamics exhibits both segregative and integrative tendencies and gives rise to both cooperative and competitive relations within and between cortical areas that are hypothesized to underlie the emergence of cognition in brains. PMID:27695395

Ushering in a New Frontier in Geospace Through Data Science

NASA Astrophysics Data System (ADS)

McGranaghan, Ryan M.; Bhatt, Asti; Matsuo, Tomoko; Mannucci, Anthony J.; Semeter, Joshua L.; Datta-Barua, Seebany

2017-12-01

Our understanding and specification of solar-terrestrial interactions benefit from taking advantage of comprehensive data-intensive approaches. These data-driven methods are taking on new importance in light of the shifting data landscape of the geospace system, which extends from the near Earth space environment, through the magnetosphere and interplanetary space, to the Sun. The space physics community faces both an exciting opportunity and an important imperative to create a new frontier built at the intersection of traditional approaches and state-of-the-art data-driven sciences and technologies. This brief commentary addresses the current paradigm of geospace science and the emerging need for data science innovation, discusses the meaning of data science in the context of geospace, and highlights community efforts to respond to the changing landscape.

[Personalized urooncology based on molecular uropathology: what is the future?].

PubMed

Dahl, E; Haller, F

2013-07-01

Targeted therapies and biomarker validation are key drivers in the advancement of personalized oncology which is a growing topic in all clinical areas. Compared with other professions, such as pulmonology and gynecology, development in urology has so far been retarded but has recently gained increasing momentum. A basis for this is the currently growing and in future accelerated application of new knowledge derived from molecular biology in the field of uropathology. The rapid gain of knowledge is driven by a whole new class of analytical methods, such as massively parallel sequencing (deep sequencing or next generation sequencing), which enables analysis of virtually a new universe of potential biomarkers. This article describes the emerging paradigm shift in molecular pathological diagnostics of urological tumors using the example of prostate cancer.

Gliotransmitters travel in time and space.

PubMed

Araque, Alfonso; Carmignoto, Giorgio; Haydon, Philip G; Oliet, Stéphane H R; Robitaille, Richard; Volterra, Andrea

2014-02-19

The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks, and ultimately behavior. In this Perspective, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons. Copyright © 2014 Elsevier Inc. All rights reserved.

Toward an Implementation Paradigm of Educational Change.

ERIC Educational Resources Information Center

Berman, Paul

Besides identifying current problems in educational change research, this document describes the inadequate paradigm on which past research has been based and outlines a currently emerging paradigm of educational innovation. The author asserts that previous research findings have been inconsistent and not comparable. Basic to the research problems…

Another Way to Think about the Work We Do: Counselling for Work and Relationship

ERIC Educational Resources Information Center

Richardson, Mary Sue

2009-01-01

Counselling for work and relationship is proposed as another way of thinking about vocational psychology and vocational guidance. It can contribute to the search for a new paradigm for these fields. Central to this way of thinking are two shifts. A shift from a discourse about career to a discourse about work, and a shift to expand the focus of…

Lessons from Popper for science, paradigm shifts, scientific revolutions and exercise physiology.

PubMed

Robergs, Robert Andrew

2017-01-01

A connection has been made to the possible role of the central governor model (CGM) to be a paradigm shift within the exercise sciences. Unfortunately, very little evidence was presented to support this notion, and a narrow view of scientific philosophy was used to reflect on the role of the CGM in understanding exercise physiology and the pursuit of a more ideal scientific method. When contrasting the scientific philosophies of Kuhn to Popper, and applying the tenant of falsification to the research and commentary on the CGM, it is probable that the scholarship pertaining to the CGM adheres more to pseudoscience than science. To improve the scientific contributions of research on the CGM, fellow scientists need to adopt a more critical platform where questions are raised and research designs are employed in efforts to refute the theory. The inability to falsify a theory is the most meaningful way to prove that it is likely to be correct. To support this development, the CGM needs to be more carefully worded to form a theory that clearly reveals key features that can be researched and potentially falsified. In addition, the wording of the CGM needs to allow scientists to make predictions that can then be tested in controlled experimental research studies. Until this happens for the CGM and all other pertinent paradigms within exercise physiology, the discipline will never rise out of the abyss of normal science to extraordinary science involving paradigm shifts and scientific revolutions.

Lessons from Popper for science, paradigm shifts, scientific revolutions and exercise physiology

PubMed Central

Robergs, Robert Andrew

2017-01-01

A connection has been made to the possible role of the central governor model (CGM) to be a paradigm shift within the exercise sciences. Unfortunately, very little evidence was presented to support this notion, and a narrow view of scientific philosophy was used to reflect on the role of the CGM in understanding exercise physiology and the pursuit of a more ideal scientific method. When contrasting the scientific philosophies of Kuhn to Popper, and applying the tenant of falsification to the research and commentary on the CGM, it is probable that the scholarship pertaining to the CGM adheres more to pseudoscience than science. To improve the scientific contributions of research on the CGM, fellow scientists need to adopt a more critical platform where questions are raised and research designs are employed in efforts to refute the theory. The inability to falsify a theory is the most meaningful way to prove that it is likely to be correct. To support this development, the CGM needs to be more carefully worded to form a theory that clearly reveals key features that can be researched and potentially falsified. In addition, the wording of the CGM needs to allow scientists to make predictions that can then be tested in controlled experimental research studies. Until this happens for the CGM and all other pertinent paradigms within exercise physiology, the discipline will never rise out of the abyss of normal science to extraordinary science involving paradigm shifts and scientific revolutions. PMID:29021907

Youth Transitions and Generations: A Response to Wyn and Woodman

ERIC Educational Resources Information Center

Roberts, Ken

2007-01-01

This article presents the author's response to Wyn and Woodman (2006) who have urged shifting youth research away from a transition paradigm to a generation paradigm. The evidence that they marshal in support is mainly from Australia, but their arguments are intended to be relevant throughout the western world. Here, the author argues that Wyn and…

Future Developments of Educational Research in the Asia-Pacific Region: Paradigm Shifts, Reforms, and Practice

ERIC Educational Resources Information Center

Cheng, Yin Cheong

2007-01-01

In facing up to the challenges and impacts of globalization, high technology, economic transformation, international competitions and local developments in the new century, there have been numerous educational reforms and initiatives in many countries in the Asia-Pacific Region (Cheng, 2005a, A new paradigm for re-engineering education:…

Moving from Bureaucracy to Empowerment: Shifting Paradigms To Practice What We Preach in Class.

ERIC Educational Resources Information Center

Luechauer, David L.; Shulman, Gary M.

The empowerment paradigm with roots in the literature of education and management (both applied and theoretical) can guide faculty to help prepare students to make the transition from the classroom to the boardroom. While numerous faculty leaders have joined corporate leaders in espousing the virtues of empowerment, most classes in business…

The Shift of the University Paradigm and Reform of the Korean University Systems

ERIC Educational Resources Information Center

Lee, Hyun-Chong

2005-01-01

The 21st century society is characterised as a knowledge-based society, education mobility society, and cyber schooling society. This new paradigm of university enables us to restructure the university system in Korea. To establish an efficient and competitive education system, it is essential to change the current university system. Restructuring…

Paradigms Lost and Pragmatism Regained: Methodological Implications of Combining Qualitative and Quantitative Methods

ERIC Educational Resources Information Center

Morgan, David L.

2007-01-01

This article examines several methodological issues associated with combining qualitative and quantitative methods by comparing the increasing interest in this topic with the earlier renewal of interest in qualitative research during the 1980s. The first section argues for the value of Kuhn's concept of paradigm shifts as a tool for examining…

Forms of Generalization in Students Experiencing Mathematical Learning Difficulties

ERIC Educational Resources Information Center

Santi, George; Baccaglini-Frank, Anna

2015-01-01

We shift the view of a special needs student away from the acknowledged view, that is as a student who requires interventions to restore a currently expected functioning behaviour, introducing a new paradigm to frame special needs students' learning of mathematics. We use the theory of objectification and the new paradigm to look at (and…

From Static Stretching to Dynamic Exercises: Changing the Warm-Up Paradigm

ERIC Educational Resources Information Center

Young, Shawna

2010-01-01

In the United States, pre-exercise static stretching seems to have become common practice and routine. However, research suggests that it is time for a paradigm shift--that pre-exercise static stretching be replaced with dynamic warm-up exercises. Research indicates that a dynamic warm-up elevates body temperature, decreases muscle and joint…

Political Science and the Good Citizen: The Genealogy of Traditionalist Paradigm of Citizenship Education in the American School Curriculum

ERIC Educational Resources Information Center

Ahmad, Iftikhar

2017-01-01

Purpose: The purpose of this article is to chronicle paradigm shifts in American political science during the twentieth century and their influence on political scientists' perspectives on pre-collegiate citizenship education curriculum. Methodology: The research questions explored in this article are concerned with the history of political…

Response to Elvira Panaiotidi, "The Nature of Paradigms and Paradigm Shifts in Music Education"

ERIC Educational Resources Information Center

Waldron, Janice

2005-01-01

In her response to Elvira Panaiotidi, Janice Waldron says that Panaiotidi makes a strong case that MEAE and praxialism represent, respectively, the poesis and praxis strands of the Aristotelian conception of art and that, consequently, one cannot conclude that the two accounts are ontologically incompatible. In this article, Janice Waldron, wishes…

"Theory at the Crossroads": Mapping Moments of Mathematics Education Research onto Paradigms of Inquiry

ERIC Educational Resources Information Center

Stinson, David W.; Walshaw, Margaret

2017-01-01

In this essay, traveling through the past half-century, the authors illustrate how mathematics education research shifted, theoretical, beyond its psychological and mathematical roots. Mapping four historical moments of mathematics education research onto broader paradigms of inquiry, the authors make a case for the field to take up a theoretical…

Forum: The Lecture and Student Learning. The Lecture and the Learning Paradigm

ERIC Educational Resources Information Center

Darling, Ann

2017-01-01

The essays in this forum demonstrate how the shift from an instructional to a learning paradigm is in full motion and is happening in scholarly conversations about communication and instruction. When asked about the role of the lecture in today's educational context, responses varied from some form of "none at all" to "the lecture…

D[superscript 4]S[superscript 4]: A Four Dimensions Instructional Strategy for Web-Based and Blended Learning

ERIC Educational Resources Information Center

Abdelaziz, Hamdy A.

2012-01-01

Web-based education is facing a paradigm shift under the rapid development of information and communication technology. The new paradigm of learning requires special techniques of course design, special instructional models, and special methods of evaluation. This paper investigates the effectiveness of an adaptive instructional strategy for…

Stress and salivary cortisol in emergency medical dispatchers: A randomized shifts control trial

PubMed Central

Bedini, Sarah; Braun, François; Weibel, Laurence; Aussedat, Michel; Pereira, Bruno; Dutheil, Frédéric

2017-01-01

Stress at work is a public health concern. Phone operators in emergency medical dispatch centers are particularly at risk. We aimed to demonstrate that the most stressful time for emergency medical dispatchers is the shift when they receive emergency incoming calls, with cortisol as a biomarker of stress. For each emergency medical dispatcher, we measured outcomes over a control day and during three types of shift: Incoming emergency call, Dispatch and Re-assessment. The pattern of shifts was randomized. Saliva was sampled every 15 minutes for 2 hours, i.e. 6 consecutive times, starting 15 minutes after the first life-and-death incoming emergency call between 2 and 5 pm during three types of shift. We measured saliva cortisol every 2 hours over a control day, from 7am to 9pm. Perceived stress was assessed by a visual analog scale. We recruited 22 phone operators aged 36.4+/-10.8 years old (14 women and 8 men). Cortisol values were higher during the Incoming emergency call shift than during the Dispatch (p = .04) and Re-assessment (p = .04) shifts. The increase in cortisol levels was greater in men than in women (p = .009). There were no differences between control values and those of the three shifts. The kinetics of cortisol increased with greater perceived stress overall (p < .001) and for each type of shift (Incoming emergency call, p = .02; Dispatch p = .03; Re-assessment: p < .001). The kinetics of cortisol in response to incoming emergency calls was greater when the call was an absolute emergency (p = .03), and also tended to further increase when a subsequent absolute incoming emergency call was received (p = 0.07). In conclusion, the incoming emergency call shift carries particular risk for dispatchers, who have greater perceived stress and a greater increase in cortisol levels. PMID:28505199

Stress and salivary cortisol in emergency medical dispatchers: A randomized shifts control trial.

PubMed

Bedini, Sarah; Braun, François; Weibel, Laurence; Aussedat, Michel; Pereira, Bruno; Dutheil, Frédéric

2017-01-01

Stress at work is a public health concern. Phone operators in emergency medical dispatch centers are particularly at risk. We aimed to demonstrate that the most stressful time for emergency medical dispatchers is the shift when they receive emergency incoming calls, with cortisol as a biomarker of stress. For each emergency medical dispatcher, we measured outcomes over a control day and during three types of shift: Incoming emergency call, Dispatch and Re-assessment. The pattern of shifts was randomized. Saliva was sampled every 15 minutes for 2 hours, i.e. 6 consecutive times, starting 15 minutes after the first life-and-death incoming emergency call between 2 and 5 pm during three types of shift. We measured saliva cortisol every 2 hours over a control day, from 7am to 9pm. Perceived stress was assessed by a visual analog scale. We recruited 22 phone operators aged 36.4+/-10.8 years old (14 women and 8 men). Cortisol values were higher during the Incoming emergency call shift than during the Dispatch (p = .04) and Re-assessment (p = .04) shifts. The increase in cortisol levels was greater in men than in women (p = .009). There were no differences between control values and those of the three shifts. The kinetics of cortisol increased with greater perceived stress overall (p < .001) and for each type of shift (Incoming emergency call, p = .02; Dispatch p = .03; Re-assessment: p < .001). The kinetics of cortisol in response to incoming emergency calls was greater when the call was an absolute emergency (p = .03), and also tended to further increase when a subsequent absolute incoming emergency call was received (p = 0.07). In conclusion, the incoming emergency call shift carries particular risk for dispatchers, who have greater perceived stress and a greater increase in cortisol levels.

Education at a Distance.

ERIC Educational Resources Information Center

Maffett, Sheryl Price

2007-01-01

Distance learning has been around since the old "course in a box" correspondence classes, but with the advent of sophisticated online course management systems, learning at a distance is contributing to a major paradigm shift in higher education. That shift includes applying corporate concepts to education--students, for example, are "consumers,"…

Researching IT in Education

ERIC Educational Resources Information Center

Cox, M. J.; Niederhauser, D. S.; Castillo, N.; McDougall, A. B.; Sakamoto, T.; Roesvik, S.

2013-01-01

Many regions around the world are experiencing a gradual paradigm shift away from information technology (IT) use that complements traditional teaching and towards embedded IT use in E-learning that is ubiquitous and pervasive. This has been conceptualized in this article using a framework depicting the affects of these shifts on learning…

Development to Learning: Semantic Shifts in Professional Autonomy and School Leadership

ERIC Educational Resources Information Center

Stevenson, Michael; Hedberg, John G.; O'Sullivan, Kerry-Ann; Howe, Cathie

2015-01-01

In the digital age, technology is playing an important role in changing the nature of professionalism. Newer forms of "professional learning" stand in contrast to more traditional forms of "professional development." The shifting paradigm has implications for school leaders in all contexts. This study sought to qualitatively…

Shifting Educational Paradigms: From Traditional to Competency-Based Education for Diverse Learners

ERIC Educational Resources Information Center

Sullivan, Susan C.; Downey, Jayne A.

2015-01-01

In pursuit of innovative educational opportunities, district administration piloted competency-based education in their alternative program. This qualitative study used semi-structured interviews with school personnel to document perspectives of the programmatic shift. Analyses found local and national mandates, a catalyst, and a common moral…

Horizon Mission Methodology - A tool for the study of technology innovation and new paradigms

NASA Technical Reports Server (NTRS)

Anderson, John L.

1993-01-01

The Horizon Mission (HM) methodology was developed to provide a means of identifying and evaluating highly innovative, breakthrough technology concepts (BTCs) and for assessing their potential impact on advanced space missions. The methodology is based on identifying new capabilities needed by hypothetical 'horizon' space missions having performance requirements that cannot be met even by extrapolating known space technologies. Normal human evaluation of new ideas such as BTCs appears to be governed (and limited) by 'inner models of reality' defined as paradigms. Thus, new ideas are evaluated by old models. This paper describes the use of the HM Methodology to define possible future paradigms that would provide alternatives to evaluation by current paradigms. The approach is to represent a future paradigm by a set of new BTC-based capabilities - called a paradigm abstract. The paper describes methods of constructing and using the abstracts for evaluating BTCs for space applications and for exploring the concept of paradigms and paradigm shifts as a representation of technology innovation.

From sedentary to active: Shifting the movement paradigm in workplaces.

PubMed

Das, Bhibha M; Mailey, Emily; Murray, Kate; Phillips, Siobhan M; Torres, Cam; King, Abby C

2016-06-08

Increased sedentary behavior and reduced physical activity are risk factors for morbidity and mortality. As adults spend a significant portion of their time at work where the default is to spend the majority of the day sitting, shifting workplace norms to decrease sedentary time and increase active time could have a public health impact. Workplaces offer a unique setting for multi-level interventions that can reach diverse populations. Traditional worksite wellness initiatives have produced equivocal results in terms of increasing physical activity. One reason for this may be the focus on corporate-fitness type programs and health education with little change in workplace culture. More innovative approaches combining theory-based worksite wellness components with behavioral economics approaches promoting incidental physical activity at the workplace to make activity the default may be necessary. This article discusses strategies to shift the workplace paradigm from being sedentary to more active using a range of approaches.

Bias to negative emotions: a depression state-dependent marker in adolescent major depressive disorder.

PubMed

Maalouf, Fadi T; Clark, Luke; Tavitian, Lucy; Sahakian, Barbara J; Brent, David; Phillips, Mary L

2012-06-30

The aim of the current research was to examine for the first time the extent to which bias to negative emotions in an inhibitory control paradigm is a state or trait marker in major depressive disorder (MDD) in adolescents. We administered the affective go/no go task which measures the ability to switch attention to or away from positive or negative emotional stimuli to 40 adolescents with MDD (20 in acute episode (MDDa) and 20 in remission (MDDr)) and 17 healthy controls (HC). MDDa were significantly faster on the shift to negative target blocks as compared to shift to positive target blocks while HC and MDDr displayed the opposite pattern as measured by an "emotional bias index" (EBI=latency (shift to negative targets)-latency (shift to positive targets)). There was also a trend for an effect of group on commission errors, suggesting more impulsive responding by MDDa than both MDDr and HC independently of stimulus valence throughout the task. Negative bias was not associated with depression severity or medication status. In conclusion, bias to negative emotional stimuli appears to be present in the acute stage of MDD and absent in remission suggesting that it is a depression state-specific marker of MDD in adolescents. Latency emerges as a better proxy of negative bias than commission errors and accuracy on this inhibitory control task in adolescents with MDD. Copyright © 2012 Elsevier Ltd. All rights reserved.

Constantly Weighing the Pig Will Not Make It Grow: Do Teachers Teach Assessment Tests or the Curriculum?

ERIC Educational Resources Information Center

le Cordeur, Michael

2014-01-01

For a number of years now, South Africa, like many other countries, has been debating a major paradigm shift in education, a shift from learning and teaching, which focused primarily on content to learning and teaching focused on outcomes. One of the most dramatic trends in education over the past decade has been the shift towards the use of…

FuturICT: Participatory computing to understand and manage our complex world in a more sustainable and resilient way

NASA Astrophysics Data System (ADS)

Helbing, D.; Bishop, S.; Conte, R.; Lukowicz, P.; McCarthy, J. B.

2012-11-01

We have built particle accelerators to understand the forces that make up our physical world. Yet, we do not understand the principles underlying our strongly connected, techno-socio-economic systems. We have enabled ubiquitous Internet connectivity and instant, global information access. Yet we do not understand how it impacts our behavior and the evolution of society. To fill the knowledge gaps and keep up with the fast pace at which our world is changing, a Knowledge Accelerator must urgently be created. The financial crisis, international wars, global terror, the spreading of diseases and cyber-crime as well as demographic, technological and environmental change demonstrate that humanity is facing serious challenges. These problems cannot be solved within the traditional paradigms. Moving our attention from a component-oriented view of the world to an interaction-oriented view will allow us to understand the complex systems we have created and the emergent collective phenomena characterising them. This paradigm shift will enable new solutions to long-standing problems, very much as the shift from a geocentric to a heliocentric worldview has facilitated modern physics and the ability to launch satellites. The FuturICT flagship project will develop new science and technology to manage our future in a complex, strongly connected world. For this, it will combine the power of information and communication technology (ICT) with knowledge from the social and complexity sciences. ICT will provide the data to boost the social sciences into a new era. Complexity science will shed new light on the emergent phenomena in socially interactive systems, and the social sciences will provide a better understanding of the opportunities and risks of strongly networked systems, in particular future ICT systems. Hence, the envisaged FuturICT flagship will create new methods and instruments to tackle the challenges of the 21st century. FuturICT could indeed become one of the most important scientific endeavours ever, by revealing the principles that make socially interactive systems work well, by inspiring the creation of new platforms to explore our possible futures, and by initiating an era of social and socio-inspired innovations.

Do we face a fourth paradigm shift in medicine--algorithms in education?

PubMed

Eitel, F; Kanz, K G; Hortig, E; Tesche, A

2000-08-01

Medicine has evolved toward rationalization since the Enlightenment, favouring quantitative measures. Now, a paradigm shift toward control through formalization can be observed in health care whose structures and processes are subjected to increasing standardization. However, educational reforms and curricula do not yet adequately respond to this shift. The aim of this article is to describe innovative approaches in medical education for adapting to these changes. The study design is a descriptive case report relying on a literature review and on a reform project's evaluation. Concept mapping is used to graphically represent relationships among concepts, i.e. defined terms from educational literature. Definitions of 'concept map', 'guideline' and 'algorithm' are presented. A prototypical algorithm for organizational decision making in the project's instructional design is shown. Evaluation results of intrinsic learning motivation are demonstrated: intrinsic learning motivation depends upon students' perception of their competence exhibiting path coefficients varying from 0.42 to 0.51. Perception of competence varies with the type of learning environment. An innovative educational format, called 'evidence-based learning (EBL)' is deduced from these findings and described here. Effects of formalization consist of structuring decision making about implementation of different learning environments or about minimizing variance in teaching or learning. Unintended effects of formalization such as implementation problems and bureaucracy are discussed. Formalized tools for designing medical education are available. Specific instructional designs influence students' learning motivation. Concept maps are suitable for controlling educational quality, thus enabling the paradigm shift in medical education.

What Elements in a Sustainability Course Contribute to Paradigm Change and Action Competence? A Study at Lincoln University, New Zealand

ERIC Educational Resources Information Center

Piasentin, Flora Bonazzi; Roberts, Lin

2018-01-01

A significant shift in the dominant paradigm governing the relationship of humans with nature and society is crucial in order to change the current unsustainable practices. This article describes a pilot-study based on a Masters level sustainability course, which explored what specific content, activities and resources may contribute to promoting…

The Paradigm Shift of Vocational Guidance and Career Counseling and Its Implications for Turkey: An Evaluation from Past to Future

ERIC Educational Resources Information Center

Yesilyaprak, Binnur

2012-01-01

The effect of globalization on the economic and social changes and the new paradigms of these changes which have caused vocational guidance and career counseling services are become increasingly world-wide sociopolitical instrument. To use this instrument by effectively and responsibly as individual and socially, it is required to understand…

Through the Glass Darkly: New Paradigms for Counselors, Courage, and Spirituality in Contemporary Education

ERIC Educational Resources Information Center

Goodell, Judy; Robinson, David C.

2008-01-01

This article proposes a paradigm shift in the view of the school counselor role. Evolving from the dualistic mind/body split of traditional physics, counseling has largely focused on problem identification and attempting to fix what is wrong. The new sciences of chaos and complexity invite a more holistic view, with the psychospiritual development…

Fueling a Third Paradigm of Education: The Pedagogical Implications of Digital, Social and Mobile Media

ERIC Educational Resources Information Center

Pavlik, John V.

2015-01-01

Emerging technologies are fueling a third paradigm of education. Digital, networked and mobile media are enabling a disruptive transformation of the teaching and learning process. This paradigm challenges traditional assumptions that have long characterized educational institutions and processes, including basic notions of space, time, content,…

Treatment of Children with Speech Oral Placement Disorders (OPDs): A Paradigm Emerges

ERIC Educational Resources Information Center

Bahr, Diane; Rosenfeld-Johnson, Sara

2010-01-01

Epidemiological research was used to develop the Speech Disorders Classification System (SDCS). The SDCS is an important speech diagnostic paradigm in the field of speech-language pathology. This paradigm could be expanded and refined to also address treatment while meeting the standards of evidence-based practice. The article assists that process…

A paradigm shift in regulating and running nursing homes in Singapore.

PubMed

Wong, Gabriel H Z; Pang, Weng Sun; Yap, Philip

2014-06-01

Singapore faces a rapidly aging population. By 2030, 19% of her population will be aged 65 years and above. Other Asian countries face similar problems, with South Korea having the fastest aging population worldwide, followed by China and Thailand. With Singapore possessing an advanced aging population, its policy provides a useful case study of eldercare to cater to evolving population demographics. This article will focus specifically on nursing homes and analyze current policies toward them, synthesize recommendations to improve long-term care, and justify a paradigm shift toward more holistic, humanistic, and multidimensional care. Copyright © 2014 American Medical Directors Association, Inc. Published by Elsevier Inc. All rights reserved.

Re-envisioning global agricultural trade: time for a paradigm shift to ensure food security and population health in low-income countries.

PubMed

Pirkle, Catherine M; Poliquin, Hélène; Sia, Drissa; Kouakou, Kouassi Joseph; Sagna, Tani

2015-03-01

In this commentary, we use examples from West Africa to highlight how the liberalization of global agricultural trade exacerbates population health inequalities by threatening the livelihoods and food security of communities in low-income settings. We highlight the exploitative nature of trade agreements with West African countries demonstrating how these agreements disincentivize local agricultural investment and take jobs away from small-scale farmers. Further, we link agricultural trade liberalization to increased food insecurity, malnutrition, and exposure to environmental contaminants. Finally, we propose a paradigm shift that advocates for food sovereignty and the right to food. © The Author(s) 2014.

Breast cancer in tough economic times: disruptive technology emerging

NASA Astrophysics Data System (ADS)

Bretz, Phillip; Lynch, Richard

2012-06-01

The objective of this study was to investigate the efficacy of melding three emerging technologies: Pharmacogenomics, Modified Military Digital Infrared and Halo to establish their capability in diagnosing ultra-small breast cancers as well as other cancers. Mammography, ultrasound and MRI technologies have been available for over forty years, however, there is still no uniform utilization by women, costs continue to escalate and problems persist like high false positive rates for MRI and high false negative rates for mammography. Of the first 500 IR patients, 499 were female and 1 male. Of 550 OncoVue patients, 129 opted to undergo IR. A total of 19 were lost to follow-up. Patients who were negative on IR: 419/500 (84%). Of these, 63/419 went to biopsy because of findings of other diagnostic modalities. Of these 61/63 with negative IR had a negative biopsy. Of two missed, one was the fault of the investigator but was included. In this series 2/500 were false negative (0.4%). The sensitivity was 96% and the specificity was 79%. In total, 46 cancers were identified including five outside the breast (e.g. 2 lung cancers). A total of 92 MRIs were done and in 71/92 patients IR and MRI agreed. Using these three modalities the smallest cancer found was a 4 mm invasive cancer. The study demonstrated that these diagnostic techniques can dramatically lower cost and provide results at least as good as the older paradigms. Further research and a multicenter clinical trial are necessary to shift the paradigm of breast cancer diagnosis and treatment.

Modeling Patient-Specific Deformable Mitral Valves.

PubMed

Ginty, Olivia; Moore, John; Peters, Terry; Bainbridge, Daniel

2018-06-01

Medical imaging has advanced enormously over the last few decades, revolutionizing patient diagnostics and care. At the same time, additive manufacturing has emerged as a means of reproducing physical shapes and models previously not possible. In combination, they have given rise to 3-dimensional (3D) modeling, an entirely new technology for physicians. In an era in which 3D imaging has become a standard for aiding in the diagnosis and treatment of cardiac disease, this visualization now can be taken further by bringing the patient's anatomy into physical reality as a model. The authors describe the generalized process of creating a model of cardiac anatomy from patient images and their experience creating patient-specific dynamic mitral valve models. This involves a combination of image processing software and 3D printing technology. In this article, the complexity of 3D modeling is described and the decision-making process for cardiac anesthesiologists is summarized. The management of cardiac disease has been altered with the emergence of 3D echocardiography, and 3D modeling represents the next paradigm shift. Copyright © 2017 Elsevier Inc. All rights reserved.

Risky play and children's safety: balancing priorities for optimal child development.

PubMed

Brussoni, Mariana; Olsen, Lise L; Pike, Ian; Sleet, David A

2012-08-30

Injury prevention plays a key role in keeping children safe, but emerging research suggests that imposing too many restrictions on children's outdoor risky play hinders their development. We explore the relationship between child development, play, and conceptions of risk taking with the aim of informing child injury prevention. Generational trends indicate children's diminishing engagement in outdoor play is influenced by parental and societal concerns. We outline the importance of play as a necessary ingredient for healthy child development and review the evidence for arguments supporting the need for outdoor risky play, including: (1) children have a natural propensity towards risky play; and, (2) keeping children safe involves letting them take and manage risks. Literature from many disciplines supports the notion that safety efforts should be balanced with opportunities for child development through outdoor risky play. New avenues for investigation and action are emerging seeking optimal strategies for keeping children "as safe as necessary," not "as safe as possible." This paradigm shift represents a potential for epistemological growth as well as cross-disciplinary collaboration to foster optimal child development while preserving children's safety.

Post-Stop-Signal Adjustments: Inhibition Improves Subsequent Inhibition

ERIC Educational Resources Information Center

Bissett, Patrick G.; Logan, Gordon D.

2012-01-01

Performance in the stop-signal paradigm involves a balance between going and stopping, and one way that this balance is struck is through shifting priority away from the go task, slowing responses after a stop signal, and improving the probability of inhibition. In 6 experiments, the authors tested whether there is a corresponding shift in…

South Asia in the Global Electronic Village: Issues and Implications.

ERIC Educational Resources Information Center

Singh, Jagtar

This paper discusses issues related to developments in computer and communication technologies in south Asia. The first section considers the Internet and its impact. Paradigm shifts and globalization are addressed in the second section, including the shifts away from stand alone libraries to library and information networks, ownership to access,…

Analysis of large-scale gene expression data.

PubMed

Sherlock, G

2000-04-01

The advent of cDNA and oligonucleotide microarray technologies has led to a paradigm shift in biological investigation, such that the bottleneck in research is shifting from data generation to data analysis. Hierarchical clustering, divisive clustering, self-organizing maps and k-means clustering have all been recently used to make sense of this mass of data.

Culturally Inclusive Dance: Working with Chinese English Language Learners in the Dance Technique Classroom

ERIC Educational Resources Information Center

Johnson, Jamie A.

2018-01-01

Higher education is experiencing rapidly shifting demographics brought about by the expanding global economy. The influx of English Language Learners (ELLs) into U.S. dance classrooms is creating a shifting paradigm for students and instructors. According to Beth McMurtrie (2012), universities with increasing international enrollments recognize…

The Science of Prescribed Fire: to Enable a Different Kind of Control

Treesearch

Timothy E. Paysen; Marcia G. Narog; Jack D. Cohen

1998-01-01

A paradigm shift from fire suppression to fire suppression and prescription requires a shift in emphasis from simply controlling wildfire occurrence and spread to one that includes controlling characteristics of prescribed fire. Suppression focuses on preventing unwanted effects that might result from wildfire occurrence. Prescription promotes desired effects by...

Growing Teacher Leaders in a Culture of Excellence

ERIC Educational Resources Information Center

Searby, Linda; Shaddix, Lisa

2008-01-01

Viewing teachers as leaders requires a paradigm shift about the concept of leadership in a school system. The Teachers as Leaders program of the Mountain Brook, Alabama Schools represents that shift and is empowering teachers to utilize their leadership skills and contribute to the system as it fulfills its mission to offer education to its…

Technology and the Management of Instruction.

ERIC Educational Resources Information Center

Heinich, Robert

In his book "The Structure of Scientific Revolutions," T.S. Kuhn suggests that incipient paradigm changes in science may be detected by examining certain shifts in emphasis in the literature of a particular field. If we grant his premise, the same possibility may be true in education. An examination of recent literature shows a shift toward a…

Researcher as Instrument: Understanding "Shifting" Findings in Constructivist Research

ERIC Educational Resources Information Center

Stewart, Dafina Lazarus

2010-01-01

Two studies investigating the meaning and articulation of multiple identities among Black college students revealed shifts in the findings from the 2001 study to the 2005 study. This theoretical review explores the role of the researcher as instrument within the constructivist research paradigm as a possible explanation for some of these apparent…

Infusing Classrooms with Web 2.0 Technologies

ERIC Educational Resources Information Center

Velasco, Richard Carlos L.

2018-01-01

The evolution of digital technologies over the past couple of decades has contributed to a paradigm shift in education where the internet and web-based applications have become ubiquitous in primary and secondary classrooms (Glassman & Kang, 2011). With this shift came the digital phenomena known today as Web 2.0 technologies. Web 2.0…

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery.

PubMed

Thomas, Craig E; Will, Yvonne

2012-02-01

Attrition in the drug industry due to safety findings remains high and requires a shift in the current safety testing paradigm. Many companies are now positioning safety assessment at each stage of the drug development process, including discovery, where an early perspective on potential safety issues is sought, often at chemical scaffold level, using a variety of emerging technologies. Given the lengthy development time frames of drugs in the pharmaceutical industry, the authors believe that the impact of new technologies on attrition is best measured as a function of the quality and timeliness of candidate compounds entering development. The authors provide an overview of in silico and in vitro models, as well as more complex approaches such as 'omics,' and where they are best positioned within the drug discovery process. It is important to take away that not all technologies should be applied to all projects. Technologies vary widely in their validation state, throughput and cost. A thoughtful combination of validated and emerging technologies is crucial in identifying the most promising candidates to move to proof-of-concept testing in humans. In spite of the challenges inherent in applying new technologies to drug discovery, the successes and recognition that we cannot continue to rely on safety assessment practices used for decades have led to rather dramatic strategy shifts and fostered partnerships across government agencies and industry. We are optimistic that these efforts will ultimately benefit patients by delivering effective and safe medications in a timely fashion.

The role of dental hygiene in caries management: a new paradigm.

PubMed

Young, Douglas A; Lyon, Lucinda; Azevedo, Shelly

2010-01-01

Dental caries is the most common disease of children and remains a significant oral health problem worldwide for both children and adults. The traditional paradigm of treating dental caries solely by "drilling and filling," brushing and flossing and lowering sugar intake has evolved. Current science in the management of dental caries suggests a clear focus on the reduction of responsible infectious agents, remineralization of non-cavitated lesions and minimally invasive restorative approaches whenever possible. The paradigm shift is away from a purely surgical approach toward more preventive and curative clinical protocols. This paper provides a review of this caries management methodology and explores the role of the dental hygienist in this paradigm change.

Modelling Safe Interface Interactions in Web Applications

NASA Astrophysics Data System (ADS)

Brambilla, Marco; Cabot, Jordi; Grossniklaus, Michael

Current Web applications embed sophisticated user interfaces and business logic. The original interaction paradigm of the Web based on static content pages that are browsed by hyperlinks is, therefore, not valid anymore. In this paper, we advocate a paradigm shift for browsers and Web applications, that improves the management of user interaction and browsing history. Pages are replaced by States as basic navigation nodes, and Back/Forward navigation along the browsing history is replaced by a full-fledged interactive application paradigm, supporting transactions at the interface level and featuring Undo/Redo capabilities. This new paradigm offers a safer and more precise interaction model, protecting the user from unexpected behaviours of the applications and the browser.

Using a Paradigm Shift to Teach Neurobiology and the Nature of Science-a C.R.E.A.T.E.-based Approach.

PubMed

Hoskins, Sally G

2008-01-01

Decades ago, classic experiments established the phenomenon of "neural induction" (Spemann and Mangold, 1924; Holtfreter, 1933). It appeared clear that amphibian ectoderm was pre-programmed to form epidermis, and that the neural phenotype was induced by a chemical signal from mesoderm. The "ectoderm makes skin, unless induced to make nervous system" model appeared in many textbooks. This interpretation, however, was not simply incorrect but 180 degrees out of alignment with the actual situation. As subsequently demonstrated, the default state of amphibian ectoderm is neuronal, and the expression of the epidermal phenotype requires cell signaling (Hemmati-Brivanlou and Melton, 1992; 1994; 1997). In this activity, students are presented with key experiments in a stepwise fashion. At several points, they work in groups to devise models that explain particular experimental results. The stepwise presentation of results mirrors the history of discoveries in this experimental system. Eventually, faced with seemingly contradictory data, students must revise their models substantially and in doing so, experience the paradigm shift. The lesson also examines the history of this paradigm shift. Data inconsistent with the "epidermal default" model were published years before the "neural default" model was proposed, but the significance of the surprising new data was underemphasized by the scientists who made the discovery. Discussing this situation provides insight into how science works and highlights the possibility that working scientists may become entrenched in prevailing paradigms. Such "nature of science" discussions emphasize research as a human activity, and help to dispel student misconceptions about science and scientists.

Ecopedagogy as an element of citizenship education: The dialectic of global/local spheres of citizenship and critical environmental pedagogies

NASA Astrophysics Data System (ADS)

Misiaszek, Greg William

2016-10-01

Emerging from popular education movements in Latin America, ecopedagogy is a critical environmental pedagogy which focuses on understanding the connections between social conflict and environmentally harmful acts carried out by humans. These connections are often politically hidden in education. Ecopedagogy, while being pluralistic, is in its essence defined as a critical, transformative environmental pedagogy centred on increasing social and environmental justice. Its ultimate aim is to find a sustainable balance between the conflicting goals of diverse notions of human progress and environmental wellbeing. This article is based on two comparative research projects. The first was a qualitative study on ecopedagogical models involving 31 expert ecopedagogues in Argentina, Brazil and the Appalachian region of the United States. They were asked for their perspectives on how successful ecopedagogy can be defined within the contexts in which they taught and conducted research. The second study analysed how 18 international expert scholars of citizenship and/or environmental pedagogy from six world continents regarded the ways in which citizenship intersects with environmental issues and the pedagogies of both in an increasingly globalised world, with specific focus on Global Citizenship Education. Results from the first study indicate the following two needs for effective environmental pedagogies: (1) for there to be an ecopedagogical paradigm shift in environmental teaching and research; and (2) for ecopedagogy to be an essential element of citizenship education (and vice versa). This article examines how conflicting processes of globalisation both help and hinder in achieving such a paradigm shift by decentring traditional nation-state citizenship. Results from the second study indicate how critical teaching within and between different spheres of citizenship (e.g. local, national, global, and planetary citizenship) is essential for ecopedagogy (and the ecopedagogical element).

Cortex and Memory: Emergence of a New Paradigm

ERIC Educational Resources Information Center

Fuster, Joaquin M.

2009-01-01

Converging evidence from humans and nonhuman primates is obliging us to abandon conventional models in favor of a radically different, distributed-network paradigm of cortical memory. Central to the new paradigm is the concept of memory network or cognit--that is, a memory or an item of knowledge defined by a pattern of connections between neuron…

The Challenge of Infectious Diseases to the Biomedical Paradigm

ERIC Educational Resources Information Center

Foladori, Guillermo

2005-01-01

The resurgence of infectious diseases and the emergence of infectious diseases raise questions on how to cope with the situation. The germ or clinical approach is the hegemonic biomedical paradigm. In this article, the author argues that the spread of infectious diseases has posted a challenge to the biomedical paradigm and shows how lock-in…

Communities of Practice: A Research Paradigm for the Mixed Methods Approach

ERIC Educational Resources Information Center

Denscombe, Martyn

2008-01-01

The mixed methods approach has emerged as a "third paradigm" for social research. It has developed a platform of ideas and practices that are credible and distinctive and that mark the approach out as a viable alternative to quantitative and qualitative paradigms. However, there are also a number of variations and inconsistencies within the mixed…

QoS enabled dissemination of managed information objects in a publish-subscribe-query information broker

NASA Astrophysics Data System (ADS)

Loyall, Joseph P.; Carvalho, Marco; Martignoni, Andrew, III; Schmidt, Douglas; Sinclair, Asher; Gillen, Matthew; Edmondson, James; Bunch, Larry; Corman, David

2009-05-01

Net-centric information spaces have become a necessary concept to support information exchange for tactical warfighting missions using a publish-subscribe-query paradigm. To support dynamic, mission-critical and time-critical operations, information spaces require quality of service (QoS)-enabled dissemination (QED) of information. This paper describes the results of research we are conducting to provide QED information exchange in tactical environments. We have developed a prototype QoS-enabled publish-subscribe-query information broker that provides timely delivery of information needed by tactical warfighters in mobile scenarios with time-critical emergent targets. This broker enables tailoring and prioritizing of information based on mission needs and responds rapidly to priority shifts and unfolding situations. This paper describes the QED architecture, prototype implementation, testing infrastructure, and empirical evaluations we have conducted based on our prototype.

The State of Human Anatomy Teaching in the Medical Schools of Gulf Cooperation Council Countries: Present and future perspectives.

PubMed

Habbal, Omar

2009-04-01

Available literature on medical education charts an emerging trend in the field of anatomy. In the past decade, assisted by innovations in informatics and the paradigm shift in medical education, the hands-on experience of cadaver dissection has progressively become a relic of the past. Within the context of the situation in Gulf Cooperation Council countries, this paper compares the traditional teaching approach with the modern one that tends to emphasise technical gadgetry, virtual reality and plastic models rather than hands-on-experience to impart knowledge and skill. However, cadaver-based learning is an important building block for the future physician and surgeon since clinical astuteness is likely to rely on skills gained from hands-on experience rather than the tendency to learning through virtual reality found in modern curricula.

The evolution and future of minimalism in neurological surgery.

PubMed

Liu, Charles Y; Wang, Michael Y; Apuzzo, Michael L J

2004-11-01

The evolution of the field of neurological surgery has been marked by a progressive minimalism. This has been evident in the development of an entire arsenal of modern neurosurgical enterprises, including microneurosurgery, neuroendoscopy, stereotactic neurosurgery, endovascular techniques, radiosurgical systems, intraoperative and navigational devices, and in the last decade, cellular and molecular adjuvants. In addition to reviewing the major developments and paradigm shifts in the cyclic reinvention of the field as it currently stands, this paper attempts to identify forces and developments that are likely to fuel the irresistible escalation of minimalism into the future. These forces include discoveries in computational science, imaging, molecular science, biomedical engineering, and information processing as they relate to the theme of minimalism. These areas are explained in the light of future possibilities offered by the emerging field of nanotechnology with molecular engineering.

A Comprehensive Comparison of Current Operating Reserve Methodologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krad, Ibrahim; Ibanez, Eduardo; Gao, Wenzhong

Electric power systems are currently experiencing a paradigm shift from a traditionally static system to a system that is becoming increasingly more dynamic and variable. Emerging technologies are forcing power system operators to adapt to their performance characteristics. These technologies, such as distributed generation and energy storage systems, have changed the traditional idea of a distribution system with power flowing in one direction into a distribution system with bidirectional flows. Variable generation, in the form of wind and solar generation, also increases the variability and uncertainty in the system. As such, power system operators are revisiting the ways in whichmore » they treat this evolving power system, namely by modifying their operating reserve methodologies. This paper intends to show an in-depth analysis on different operating reserve methodologies and investigate their impacts on power system reliability and economic efficiency.« less

Influence of podiatry on orthopedic surgery at a level I trauma center.

PubMed

Jakoi, Andre M; Old, Andrew B; O'Neill, Craig A; Stein, Benjamin E; Stander, Eric P; Rosenblatt, Joseph; Herman, Martin J

2014-06-01

Level I trauma centers frequently see trauma at or below the ankle, which requires consultation with the orthopedic surgery department. However, as podiatry programs begin to firmly establish themselves in more Level I trauma centers, their consultations increase, ultimately taking those once seen by orthopedic surgery. A review of the literature demonstrates that this paradigm shift has yet to be discussed. The purpose of this study was to determine how many, if any, lower extremity fracture consultations a newly developed podiatry program would take from the orthopedic surgery department. A retrospective review was performed of emergency department records from January 2007 to December 2011. Seventeen different emergency department diagnoses were used to search the database. Ultimately, each patient's emergency department course was researched. Several trends were noted. First, if trauma surgery was involved, only the orthopedic surgery department was consulted for any injuries at or below the ankle. Second, the emergency department tended to consult the podiatry program only between the hours of 8 am and 6 pm. Third, as the podiatry program became more established, their number of consultations increased yearly, and, coincidentally, the orthopedic surgery department's consultations decreased. Finally, high-energy traumas involved only the orthopedic surgery department. Whether the orthopedic surgery department or podiatry program is consulted regarding trauma surgery is likely hospital dependent. Copyright 2014, SLACK Incorporated.

Developing sustainability: a new metaphor for progress.

PubMed

Bensimon, Cécile M; Benatar, Solomon R

2006-01-01

In this paper, we propose a new model for development, one that transcends the North-South dichotomy and goes beyond a narrow conception of development as an economic process. This model requires a paradigm shift toward a new metaphor that develops sustainability, rather than sustains development. We conclude by defending a 'report card on development' as a means for evaluating how countries perform within this new paradigm.

Contribution of the Priming Paradigm to the Understanding of the Conceptual Developmental Shift from 5 to 9 Years of Age

ERIC Educational Resources Information Center

Perraudin, Sandrine; Mounoud, Pierre

2009-01-01

We conducted three experiments to study the role of instrumental (e.g. "knife-bread") and categorical (e.g. "cake-bread") relations in the development of conceptual organization with a priming paradigm, by varying the nature of the task (naming--Experiment 1--or categorical decision--Experiments 2 and 3). The participants were 5-, 7- and…

The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host Immune-Centered Factors

PubMed Central

Donadon, Matteo; Lleo, Ana; Di Tommaso, Luca; Soldani, Cristiana; Franceschini, Barbara; Roncalli, Massimo; Torzilli, Guido

2018-01-01

The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system. PMID:29892573

THE EFFECTS OF SEVERAL VERBAL PRETRAINING CONDITIONS ON PRESCHOOL CHILDREN'S TRANSFER IN PROBLEM SOLVING. FINAL REPORT.

ERIC Educational Resources Information Center

BERNHEIM, GLORIA D.

THREE- AND 4-YEAR-OLDS WERE GIVEN VERBAL LEARNING PRETRAINING TO DETERMINE ITS EFFECT UPON THE PERFORMANCE OF REVERSAL AND NONREVERSAL SHIFT DISCRIMINATION TASKS. THE EXPERIMENTAL TASK WAS THE CLASSICAL REVERSAL-NONREVERSAL SHIFT PARADIGM. THE 96 PRE-SCHOOLERS, PRIMARILY FROM THE PENNSYLVANIA STATE UNIVERSITY NURSERY SCHOOL, WERE DIVIDED INTO 4…

Philosopher to Moderator: The Shifting Paradigm of "Ethos" in Education.

ERIC Educational Resources Information Center

Raign, Kathryn Rosser

The classical concept of "ethos" (the establishing of the speaker or writer's credibility, his or her moral character) has acquired many meanings over the centuries and has played an important role in determining the many shifting perceptions of the teacher's role, both in the classical period and the modern period. The issue can be…

From Content-Centred to Learning-Centred Approaches: Shifting Educational Paradigm in Higher Education

ERIC Educational Resources Information Center

Rege Colet, Nicole Mary

2017-01-01

This article reviews changes in pedagogical approaches in higher education at the turn of the twentieth and twenty-first century from a creative perspective, by looking back from the future on the shifts that occurred in conceptions and approaches relating to teaching and learning. Reflecting on moves from one-dimensional thinking to…

From Power to Empowerment: A Paradigm Shift in Leadership

ERIC Educational Resources Information Center

Dambe, M.; Moorad, F.

2008-01-01

This article argues that there has been a clear shift in leadership approaches from those where the leader is in control and commanding i.e., power-based leadership to one where there is empowerment. Here the power comes from the followers and is shared. Burns concepts of transactional and transformational leadership are used interchangeably with…

Paradigms and progress in vocal fold restoration.

PubMed

Ford, Charles N

2008-09-01

Science advances occur through orderly steps, puzzle-solving leaps, or divergences from the accepted disciplinary matrix that occasionally result in a revolutionary paradigm shift. Key advances must overcome bias, criticism, and rejection. Examples in biological science include use of embryonic stem cells, recognition of Helicobacter pylori in the etiology of ulcer disease, and the evolution of species. Our work in vocal fold restoration reflects these patterns. We progressed through phases of tissue replacement with fillers and biological implants, to current efforts at vocal fold regeneration through tissue engineering, and face challenges of a new "systems biology" paradigm embracing genomics and proteomics.

Pediatric bipolar disorder in an era of "mindless psychiatry".

PubMed

Parry, Peter I; Levin, Edmund C

2012-01-01

Pediatric bipolar disorder (PBD) reflects shifts in conceptualizing bipolar disorder among children and adolescents since the mid-1990s. Since then, PBD diagnoses, predominantly in the United States, have increased dramatically, and the diagnosis has attracted significant controversy. During the same period, psychiatric theory and practice has become increasingly biological. The aim of this paper is to examine the rise of PBD in terms of wider systemic influences. In the context of literature referring to paradigm shifts in psychiatry, we reviewed the psychiatric literature, media cases, and information made available by investigative committees and journalists. Social historians and prominent psychiatrists describe a paradigm shift in psychiatry over recent decades: from an era of "brainless psychiatry," when an emphasis on psychodynamic and family factors predominated to the exclusion of biological factors, to a current era of "mindless psychiatry" that emphasizes neurobiological explanations for emotional and behavioral problems with limited regard for contextual meaning. Associated with this has been a tendency within psychiatry and society to neglect trauma and attachment insecurity as etiological factors; the "atheoretical" (but by default biomedical) premise of the Diagnostic and Statistical Manual of Mental Disorders (3rd and 4th eds.); the influence of the pharmaceutical industry in research, continuing medical education, and direct-to-consumer advertising; and inequality in the U.S. health system that favors "diagnostic upcoding." Harm from overmedicating children is now a cause of public concern. It can be argued that PBD as a widespread diagnosis, particularly in the United States, reflects multiple factors associated with a paradigm shift within psychiatry rather than recognition of a previously overlooked common disorder.

Issues and challenges of curriculum reform to competency-based curricula in Africa: A meta-synthesis.

PubMed

Muraraneza, Claudine; Mtshali, Ntombifikile Gloria; Mukamana, Donatilla

2017-03-01

Although in recent decades reforms to undergraduate nursing and midwifery education have increasingly been guided by the concept of competency-based curriculum in a drive to produce competent graduates in the African context, the topic remains poorly researched in-depth. The related issues and challenges need to be explored in the interest of evidence-based practice. This article stems from a systematic review of qualitative literature on the design and implementation of competency-based curriculum. Data was inductively analyzed using constant comparison. The two categories that emerged were: (i) the need for a paradigm shift to competency-based curriculum; and (ii) the associated issues and challenges, such as a shift from informative to transformative learning, lack or limited of involvement of key stakeholders in curriculum development, focus on hospital-oriented education, lack of preparation of educators, and inappropriate resources. While ongoing reform of nursing and midwifery education continues, much still needs to be done - in particular, extensive financial investment to increase the capacity of educators, mentors and infrastructure, and the development of collaborative frameworks between nursing and midwifery and higher educational councils. © 2016 John Wiley & Sons Australia, Ltd.

The Bohr effect before Perutz.

PubMed

Brunori, Maurizio

2012-01-01

Before the outbreak of World War II, Jeffries Wyman postulated that the Bohr effect in hemoglobin demanded the oxygen linked dissociation of the imidazole of two histidines of the polypeptide. This proposal emerged from a rigorous analysis of the acid-base titration curves of oxy- and deoxy-hemoglobin, at a time when the information on the chemistry and structure of the protein was essentially nil. The magnetochemical properties of hemoglobin led Linus Pauling to hypothesize that the (so called) Bohr histidines were coordinated to the heme iron in the fifth and sixth positions; and Wyman shared this opinion. However, this structural hypothesis was abandoned in 1951 when J. Wyman and D. W. Allen proposed the pK shift of the oxygen linked histidines to be the result of "...a change of configuration of the hemoglobin molecule as a whole accompanying oxygenation." This shift in paradigm, that was published well before the 3D structure of hemoglobin was solved by M.F. Perutz, paved the way to the concept of allostery. After 1960 the availability of the crystallographic structure opened new horizons to the interpretation of the allosteric properties of hemoglobin. Copyright © 2012 Wiley Periodicals, Inc.

Paving the road ahead for CD19 CAR T-cell therapy.

PubMed

Nellan, Anandani; Lee, Daniel W

2015-11-01

Modern immunotherapies, most notably in the form of anti-CD19 chimeric antigen receptor (CAR) T cells, have produced significant clinical responses in otherwise refractory pre-B-cell acute lymphoblastic leukemia patients. Several groups have simultaneously reported robust response rates in children and adults alike. These early studies indicate an impending shift in paradigm for the treatment of acute lymphoblastic leukemia. Incorporating CD19 CAR T-cell therapy into upfront or salvage regimens has its challenges and opportunities. Most CD19 CAR T-cell products in trial today are excellent at inducing minimal residual disease negative remissions, and most responding patients experience cytokine release syndrome and/or neurotoxicity. The challenges facing the CAR community involve how best to minimize the severity of cytokine release syndrome and neurotoxicity while maximizing antitumor efficacy, determining what role this therapy will play for the prophylaxis and treatment of central nervous system leukemia, and its implications on subsequent hematopoietic stem cell transplant given the emergence of CD19-negative relapses. CD19 CAR T-cell therapy is a powerful new tool in the oncologist's arsenal. How it is incorporated into standard practice and how it will shift survival curves are the exciting questions that are waiting to be answered.

Complementary development of prevention and mental health promotion programs for Canadian children based on contemporary scientific paradigms.

PubMed

Breton, J J

1999-04-01

Confusion regarding definitions and standards of prevention and promotion programs is pervasive, as revealed by a review of such programs in Canada. This paper examines how a discussion of scientific paradigms can help clarify models of prevention and mental health promotion and proposes the complementary development of prevention and promotion programs. A paradigm shift in science contributed to the emergence of the transactional model, advocating multiple causes and dynamic transactions between the individual and the environment. Consequently, the view of prevention applying over a linear continuum and of single stressful events causing mental disorders may no longer be appropriate. It is the author's belief that the new science of chaos theory, which addresses processes involved in the development of systems, can be applied to child development and thus to the heart of prevention and promotion programs. Critical moments followed by transitions or near-chaotic behaviours lead to stable states better adapted to the environment. Prevention programs would focus on the critical moments and target groups at risk to reduce risk factors. Promotion programs would focus on stable states and target the general population to develop age-appropriate life skills. The concept of sensitive dependence on initial conditions and certain empirical studies suggest that the programs would have the greatest impact at the beginning of life. It is hoped that this effort to organize knowledge about conceptual models of prevention and mental health promotion programs will foster the development of these programs to meet the urgent needs of Canadian children.

Presaccadic perceptual facilitation effects depend on saccade execution: evidence from the stop-signal paradigm.

PubMed

Born, Sabine; Mottet, Isaline; Kerzel, Dirk

2014-03-05

Prior to the onset of a saccadic eye movement, perception is facilitated at the saccade target location. This has been attributed to a shift of attention. To test whether presaccadic attention shifts are strictly dependent on saccade execution, we examined whether they are found when observers are required to cancel the eye movement. We combined a dual task with the stop-signal paradigm: Subjects made saccades as quickly as possible to a cued location while discriminating a stimulus either at the saccade target or at the opposite location. A stop signal was presented on a subset of trials, asking subjects to cancel the eye movement. The delay of the stop signal was adjusted to yield successful inhibition of the saccade in 50% of trials. Results show similar perceptual facilitation at the saccade target for saccades with or without a stop signal, suggesting that presaccadic attention shifts are obligatory for all saccades. However, there was facilitation only when saccades were actually performed, not when observers successfully inhibited them. Thus, preparing an eye movement without subsequently executing it does not result in an attention shift. The results speak to a difference between saccade preparation and saccade programming. In light of the strong dependence on saccade execution, we discuss the functional role and causes of presaccadic attention shifts.

When scientific paradigms lead to tunnel vision: lessons from the study of fear

NASA Astrophysics Data System (ADS)

Paré, Denis; Quirk, Gregory J.

2017-03-01

For the past 30 years, research on the amygdala has largely focused on the genesis of defensive behaviors as its main function. This focus originated from early lesion studies and was supported by extensive anatomical, physiological, and pharmacological data. Here we argue that while much data is consistent with the fear model of amygdala function, it has never been directly tested, in part due to overreliance on the fear conditioning task. In support of the fear model, amygdala neurons appear to signal threats and/or stimuli predictive of threats. However, recent studies in a natural threat setting show that amygdala activity does not correlate with threats, but simply with the movement of the rat, independent of valence. This was true for both natural threats as well as conditioned stimuli; indeed there was no evidence of threat signaling in amygdala neurons. Similar findings are emerging for prefrontal neurons that modulate the amygdala. These recent developments lead us to propose a new conceptualization of amygdala function whereby the amygdala inhibits behavioral engagement. Moreover, we propose that the goal of understanding the amygdala will be best served by shifting away from fear conditioning toward naturalistic approach and avoidance paradigms that involve decision-making and a larger repertoire of spontaneous and learned behaviors, all the while keeping an open mind.

Jackson State University's Center for Spatial Data Research and Applications: New facilities and new paradigms

NASA Technical Reports Server (NTRS)

Davis, Bruce E.; Elliot, Gregory

1989-01-01

Jackson State University recently established the Center for Spatial Data Research and Applications, a Geographical Information System (GIS) and remote sensing laboratory. Taking advantage of new technologies and new directions in the spatial (geographic) sciences, JSU is building a Center of Excellence in Spatial Data Management. New opportunities for research, applications, and employment are emerging. GIS requires fundamental shifts and new demands in traditional computer science and geographic training. The Center is not merely another computer lab but is one setting the pace in a new applied frontier. GIS and its associated technologies are discussed. The Center's facilities are described. An ARC/INFO GIS runs on a Vax mainframe, with numerous workstations. Image processing packages include ELAS, LIPS, VICAR, and ERDAS. A host of hardware and software peripheral are used in support. Numerous projects are underway, such as the construction of a Gulf of Mexico environmental data base, development of AI in image processing, a land use dynamics study of metropolitan Jackson, and others. A new academic interdisciplinary program in Spatial Data Management is under development, combining courses in Geography and Computer Science. The broad range of JSU's GIS and remote sensing activities is addressed. The impacts on changing paradigms in the university and in the professional world conclude the discussion.

General Relativity without paradigm of space-time covariance, and resolution of the problem of time

NASA Astrophysics Data System (ADS)

Soo, Chopin; Yu, Hoi-Lai

2014-01-01

The framework of a theory of gravity from the quantum to the classical regime is presented. The paradigm shift from full space-time covariance to spatial diffeomorphism invariance, together with clean decomposition of the canonical structure, yield transparent physical dynamics and a resolution of the problem of time. The deep divide between quantum mechanics and conventional canonical formulations of quantum gravity is overcome with a Schrödinger equation for quantum geometrodynamics that describes evolution in intrinsic time. Unitary time development with gauge-invariant temporal ordering is also viable. All Kuchar observables become physical; and classical space-time, with direct correlation between its proper times and intrinsic time intervals, emerges from constructive interference. The framework not only yields a physical Hamiltonian for Einstein's theory, but also prompts natural extensions and improvements towards a well behaved quantum theory of gravity. It is a consistent canonical scheme to discuss Horava-Lifshitz theories with intrinsic time evolution, and of the many possible alternatives that respect 3-covariance (rather than the more restrictive 4-covariance of Einstein's theory), Horava's "detailed balance" form of the Hamiltonian constraint is essentially pinned down by this framework. Issues in quantum gravity that depend on radiative corrections and the rigorous definition and regularization of the Hamiltonian operator are not addressed in this work.

Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis.

PubMed

Ghasemi, Mojtaba; Nabipour, Iraj; Omrani, Abdolmajid; Alipour, Zeinab; Assadi, Majid

2016-01-01

This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes. Precision medicine is progressively becoming a hot topic in all disciplines related to biomedical investigation and has the capacity to become the paradigm for clinical practice. The future of medicine lies in early diagnosis and individually appropriate treatments, a concept that has been named precision medicine, i.e. delivering the right treatment to the right patient at the right time. Molecular imaging is quickly being recognized as a tool with the potential to ameliorate every aspect of cancer treatment. On the other hand, emerging high-throughput technologies such as omics techniques and systems approaches have generated a paradigm shift for biological systems in advanced life science research. In this review, we describe the precision medicine, difference between precision medicine and personalized medicine, precision medicine initiative, systems biology/medicine approaches (such as genomics, radiogenomics, transcriptomics, proteomics, and metabolomics), P4 medicine, relationship between systems biology/medicine approaches and precision medicine, and molecular imaging modalities and their utility in cancer treatment and diagnosis. Accordingly, the precision medicine and molecular imaging will enable us to accelerate and improve cancer management in future medicine.

Nuclear Molecular and Theranostic Imaging for Differentiated Thyroid Cancer

PubMed Central

Sheikh, Arif; Polack, Berna; Rodriguez, Yvette; Kuker, Russ

2017-01-01

Traditional nuclear medicine is rapidly being transformed by the evolving concepts in molecular imaging and theranostics. The utility of new approaches in differentiated thyroid cancer (DTC) diagnostics and therapy has not been fully appreciated. The clinical information, relevant to disease management and patient care, obtained by scintigraphy is still being underestimated. There has been a trend towards moving away from the use of radioactive iodine (RAI) imaging in the management of the disease. This paradigm shift is supported by the 2015 American Thyroid Association Guidelines (1). A more systematic and comprehensive understanding of disease pathophysiology and imaging methodologies is needed for optimal utilization of different imaging modalities in the management of DTC. There have been significant developments in radiotracer and imaging technology, clinically proven to contribute to the understanding of tumor biology and the clinical assessment of patients with DTC. The research and development in the field continues to evolve, with expected emergence of many novel diagnostic and therapeutic techniques. The role for nuclear imaging applications will continue to evolve and be reconfigured in the changing paradigm. This article aims to review the clinical uses and controversies surrounding the use of scintigraphy, and the information it can provide in assisting in the management and treatment of DTC. PMID:28117289

Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis

PubMed Central

Ghasemi, Mojtaba; Nabipour, Iraj; Omrani, Abdolmajid; Alipour, Zeinab; Assadi, Majid

2016-01-01

This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes. Precision medicine is progressively becoming a hot topic in all disciplines related to biomedical investigation and has the capacity to become the paradigm for clinical practice. The future of medicine lies in early diagnosis and individually appropriate treatments, a concept that has been named precision medicine, i.e. delivering the right treatment to the right patient at the right time. Molecular imaging is quickly being recognized as a tool with the potential to ameliorate every aspect of cancer treatment. On the other hand, emerging high-throughput technologies such as omics techniques and systems approaches have generated a paradigm shift for biological systems in advanced life science research. In this review, we describe the precision medicine, difference between precision medicine and personalized medicine, precision medicine initiative, systems biology/medicine approaches (such as genomics, radiogenomics, transcriptomics, proteomics, and metabolomics), P4 medicine, relationship between systems biology/medicine approaches and precision medicine, and molecular imaging modalities and their utility in cancer treatment and diagnosis. Accordingly, the precision medicine and molecular imaging will enable us to accelerate and improve cancer management in future medicine. PMID:28078184

Early sensory encoding of affective prosody: neuromagnetic tomography of emotional category changes.

PubMed

Thönnessen, Heike; Boers, Frank; Dammers, Jürgen; Chen, Yu-Han; Norra, Christine; Mathiak, Klaus

2010-03-01

In verbal communication, prosodic codes may be phylogenetically older than lexical ones. Little is known, however, about early, automatic encoding of emotional prosody. This study investigated the neuromagnetic analogue of mismatch negativity (MMN) as an index of early stimulus processing of emotional prosody using whole-head magnetoencephalography (MEG). We applied two different paradigms to study MMN; in addition to the traditional oddball paradigm, the so-called optimum design was adapted to emotion detection. In a sequence of randomly changing disyllabic pseudo-words produced by one male speaker in neutral intonation, a traditional oddball design with emotional deviants (10% happy and angry each) and an optimum design with emotional (17% happy and sad each) and nonemotional gender deviants (17% female) elicited the mismatch responses. The emotional category changes demonstrated early responses (<200 ms) at both auditory cortices with larger amplitudes at the right hemisphere. Responses to the nonemotional change from male to female voices emerged later ( approximately 300 ms). Source analysis pointed at bilateral auditory cortex sources without robust contribution from other such as frontal sources. Conceivably, both auditory cortices encode categorical representations of emotional prosodic. Processing of cognitive feature extraction and automatic emotion appraisal may overlap at this level enabling rapid attentional shifts to important social cues. Copyright (c) 2009 Elsevier Inc. All rights reserved.

The evolving potential of companion diagnostics.

PubMed

Khoury, Joseph D

2016-01-01

The scope of companion diagnostics in cancer has undergone significant shifts in the past few years, with increased development of targeted therapies and novel testing platforms. This has provided new opportunities to effect unprecedented paradigm shifts in the application of personalized medicine principles for patients with cancer. These shifts involve assay platforms, analytes, regulations, and therapeutic approaches. As opportunities involving each of these facets of companion diagnostics expand, close collaborations between key stakeholders should be enhanced to ensure optimal performance characteristics and patient outcomes.

From Paradigm to Practice in Linguistics. Papers from the Michigan Linguistic Society Meeting, Vol. 1, No. 2.

ERIC Educational Resources Information Center

Hendriksen, Dan

It is important that we reflect on the conceptual framework from which our study of language has emerged, since the problems, methods, and aims of what has been called modern linguistics are rapidly being replaced by the concerns of another framework or paradigm. Such new paradigms, to be viable, must not be distorted by starting points that…

Modeling the peak of emergence in systems: Design and katachi.

PubMed

Cardier, Beth; Goranson, H T; Casas, Niccolo; Lundberg, Patric; Erioli, Alessio; Takaki, Ryuji; Nagy, Dénes; Ciavarra, Richard; Sanford, Larry D

2017-12-01

It is difficult to model emergence in biological systems using reductionist paradigms. A requirement for computational modeling is that individual entities can be recorded parametrically and related logically, but their transformation into whole systems cannot be captured this way. The problem stems from an inability to formally represent the implicit influences that inform emergent organization, such as context, shifts in causal agency or scale, and self-reference. This lack hampers biological systems modeling and its computational counterpart, indicating a need for new fundamental abstraction frameworks that support system-level characteristics. We develop an approach that formally captures these characteristics, focusing on the way they come together to enable transformation at the 'peak' of the emergent process. An example from virology is presented, in which two seemingly antagonistic systems - the herpes cold sore virus and its host - are capable of altering their basic biological objectives to achieve a new equilibrium. The usual barriers to modeling this process are overcome by incorporating mechanisms from practices centered on its emergent peak: design and katachi. In the Japanese science of form, katachi refers to the emergence of intrinsic structure from real situations, where an optimal balance between implicit influences is achieved. Design indicates how such optimization is guided by principles of flow. These practices leverage qualities of situated abstraction, which we understand through the intuitive method of physicist Kôdi Husimi. Early results indicate that this approach can capture the functional transformations of biological emergence, whilst being reasonably computable. Due to its geometric foundations and narrative-based extension to logic, the method will also generate speculative predictions. This research forms the foundations of a new biomedical modeling platform, which is discussed. Copyright © 2017. Published by Elsevier Ltd.

Postmodernism versus Professionalism in Higher Education. Thematic Reflections on Higher Education

ERIC Educational Resources Information Center

Milliken, John

2004-01-01

A global paradigm shift is taking place at the beginning of the Twenty-First Century, which is resulting in massive changes in the frames of reference about the ways of life, work, and society and how they are viewed and organized. This shift is essentially a sweeping set of worldwide changes in the public domain which challenges the prevailing…

Training Counselors to Work Competently with Individuals and Families with Health and Mental Health Issues

ERIC Educational Resources Information Center

Sperry, Len

2012-01-01

A paradigm shift is underway in the training of professional counselors. It involves a shift in orientation from an input-based or traditional model of training to an outcomes-based or competency-based model of training. This article provides a detailed description of both input-based and outcomes-based training and instructional methods. It…

Walking the Walk: Modeling Social Model and Universal Design in the Disabilities Office

ERIC Educational Resources Information Center

Thornton, Melanie; Downs, Sharon

2010-01-01

Making the shift from the medical model of disability to the social model requires postsecondary disabilities offices to carefully examine and revise policies and procedures to reflect this paradigm shift, which gives them the credibility to work toward such change on the campus level. The process followed by one university is covered in-depth, as…

Examining Harasim's Online Collaborative Learning Theory for Nursing Education

ERIC Educational Resources Information Center

Breen, Henny

2013-01-01

Online nursing education has been evolving at a rapid pace as it is recognized as offering the flexibility needed for practicing associate degree (ADN) and diploma prepared Registered Nurses to return to school to earn their BSN. At the same time, there is a paradigm shift in how nursing education is delivered. The focus has shifted from content…

Building Harmony and Peace through Multiculturalist Theology-Based Religious Education: An Alternative for Contemporary Indonesia

ERIC Educational Resources Information Center

Baidhawy, Zakiyuddin

2007-01-01

Indonesia has experienced a paradigm shift during the last decade in the framework of managing societal diversity because of an increase in ethnic and religious conflict. This shift has an impact on education because school curricula must address issues of living together as a nation united despite differences in religion and ethnicity. This is…

LinguaFolio Goal Setting Intervention and Academic Achievement: Increasing Student Capacity for Self-Regulated Learning

ERIC Educational Resources Information Center

Clarke, Oxana D.

2013-01-01

In the last few decades there has been a shift from thinking less about teaching and more about learning. Such a paradigm shift from teacher-centered to student-centered instruction requires students to think about their own learning and to monitor their own learning development and language achievement. Researchers have identified goal setting…

Advising and Optimizing the Deployment of Sustainability-Oriented Technologies in the Integrated Electricity, Light-Duty Transportation, and Water Supply System

NASA Astrophysics Data System (ADS)

Tarroja, Brian

The convergence of increasing populations, decreasing primary resource availability, and uncertain climates have drawn attention to the challenge of shifting the operations of key resource sectors towards a sustainable paradigm. This is prevalent in California, which has set sustainability-oriented policies such as the Renewable Portfolio Standards and Zero-Emission Vehicle mandates. To meet these goals, many options have been identified to potentially carry out these shifts. The electricity sector is focusing on accommodating renewable power generation, the transportation sector on alternative fuel drivetrains and infrastructure, and the water supply sector on conservation, reuse, and unconventional supplies. Historical performance evaluations of these options, however, have not adequately taken into account the impacts on and constraints of co-dependent infrastructures that must accommodate them and their interactions with other simultaneously deployed options. These aspects are critical for optimally choosing options to meet sustainability goals, since the combined system of all resource sectors must satisfy them. Certain operations should not be made sustainable at the expense of rendering others as unsustainable, and certain resource sectors should not meet their individual goals in a way that hinders the ability of the entire system to do so. Therefore, this work develops and utilizes an integrated platform of the electricity, transportation, and water supply sectors to characterize the performance of emerging technology and management options while taking into account their impacts on co-dependent infrastructures and identify synergistic or detrimental interactions between the deployment of different options. This is carried out by first evaluating the performance of each option in the context of individual resource sectors to determine infrastructure impacts, then again in the context of paired resource sectors (electricity-transportation, electricity-water), and finally in the context of the combined tri-sector system. This allows a more robust basis for composing preferred option portfolios to meet sustainability goals and gives a direction for coordinating the paradigm shifts of different resource sectors. Overall, it is determined that taking into account infrastructure constraints and potential operational interactions can significantly change the evaluation of the preferred role that different technologies should fulfill in contributing towards satisfying sustainability goals in the holistic context.

Educational Sociology and Educational Administration: Problems with Paradigms, Epistemology, Research and Theory.

ERIC Educational Resources Information Center

Berrell, Michael M.; Macpherson, R. J. S.

1995-01-01

Traces the different paradigmatic pathways followed by educational sociology and educational administration. Educational sociology has followed ideostructural, interpretive, and psychosocial paradigms, with emergent holistic critical perspectives and sociobiological materialism. Educational administration has had one dominant tradition,…

'Registrar in charge shifts': learning how to run a busy emergency department.

PubMed

Craig, Simon; Dowling, Jonathan

2013-04-01

In Australasia, emergency registrars usually gain experience 'running' an ED overnight - without supervision. This paper describes the introduction of FACEM-supervised daytime 'registrar in charge' (RIC) shifts into a tertiary adult ED over a 6 month period. Each registrar was allocated at least one RIC shift during their 13 week ED term. Structured questionnaires gathered data regarding the educational impact of the shifts, any adverse effects on departmental function, changes to work practices, and perceptions of teaching and learning. Data were analysed using thematic analysis. During the study period, 16 senior ED registrars were rostered for 26 RIC shifts. Questionnaires were completed by 16/16 registrars and 13/16 emergency physicians. The RIC shifts were viewed positively by the emergency registrars - 93% reported useful feedback, felt that the shifts provided a good insight into their workplace behaviour, and that they should be rolled out across other departments. FACEMs were also positive in their evaluation, and reported little negative impact on departmental function. Major themes identified by both registrars and emergency physicians included communication skills, knowledge and experience, delegation, professionalism and organisational skills. Additional themes that were more prominent in FACEM responses included multitasking, dealing with interruptions, managing patient flow and being aware of the whole department. RIC shifts are a feasible and acceptable method to teach running the floor in the ED. Further study should assess impact on patient outcomes. © 2013 The Authors. EMA © 2013 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

Contrasting academic and lay press print coverage of the 2013-2016 Ebola Virus Disease outbreak

PubMed Central

Kieh, Mark D.; Cho, Elim M.

2017-01-01

Under a traditional paradigm, only those with the expected background knowledge consume academic literature. The lay press, as well as government and non-government agencies, play a complementary role of extracting findings of high interest or importance and translating them for general viewing. The need for accurate reporting and public advising is paramount when attempting to tackle epidemic outbreaks through behavior change. Yet, public trust in media outlets is at a historic low. The Crisis and Emergency Risk Communication (CERC) model for media reporting on public health emergencies was established in 2005 and has subsequently been used to analyze media reporting on outbreaks of influenza and measles as well as smoking habits and medication compliance. However, no media analysis had yet been performed on the 2013–2016 Ebola Virus Disease (EVD) outbreak. This study compared the EVD information relayed by lay press sources with general review articles in the academic literature through a mixed-methods analysis. These findings suggest that comprehensive review articles could not serve as a source to clarify and contextualize the uncertainties around the EVD outbreak, perhaps due to adherence to technical accuracy at the expense of clarity within the context of outbreak conditions. This finding does not imply inferiority of the academic literature, nor does it draw direct causation between confusion in review articles and public misunderstanding. Given the erosion of the barriers siloing academia, combined with the demands of today’s fast-paced media environment, contemporary researchers should realize that no study is outside the public forum and to therefore consider shifting the paradigm to take personal responsibility in the process of accurately translating their scientific words into public policy actions to best serve as a source of clarity. PMID:28640889

Silicateins--a novel paradigm in bioinorganic chemistry: enzymatic synthesis of inorganic polymeric silica.

PubMed

Müller, Werner E G; Schröder, Heinz C; Burghard, Zaklina; Pisignano, Dario; Wang, Xiaohong

2013-05-03

The inorganic matrix of the siliceous skeletal elements of sponges, that is, spicules, is formed of amorphous biosilica. Until a decade ago, it remained unclear how the hard biosilica monoliths of the spicules are formed in sponges that live in a silica-poor (<50 μM) aquatic environment. The following two discoveries caused a paradigm shift and allowed an elucidation of the processes underlying spicule formation; first the discovery that in the spicules only one major protein, silicatein, exists and second, that this protein displays a bio-catalytical, enzymatic function. These findings caused a paradigm shift, since silicatein is the first enzyme that catalyzes the formation of an inorganic polymer from an inorganic monomeric substrate. In the present review the successive steps, following the synthesis of the silicatein product, biosilica, and resulting in the formation of the hard monolithic spicules is given. The new insight is assumed to open new horizons in the field of biotechnology and also in biomedicine. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PRISM framework: a paradigm shift for designing, strengthening and evaluating routine health information systems

PubMed Central

Aqil, Anwer; Lippeveld, Theo; Hozumi, Dairiku

2009-01-01

The utility and effectiveness of routine health information systems (RHIS) in improving health system performance in developing countries has been questioned. This paper argues that the health system needs internal mechanisms to develop performance targets, track progress, and create and manage knowledge for continuous improvement. Based on documented RHIS weaknesses, we have developed the Performance of Routine Information System Management (PRISM) framework, an innovative approach to design, strengthen and evaluate RHIS. The PRISM framework offers a paradigm shift by putting emphasis on RHIS performance and incorporating the organizational, technical and behavioural determinants of performance. By describing causal pathways of these determinants, the PRISM framework encourages and guides the development of interventions for strengthening or reforming RHIS. Furthermore, it conceptualizes and proposes a methodology for measuring the impact of RHIS on health system performance. Ultimately, the PRISM framework, in spite of its challenges and competing paradigms, proposes a new agenda for building and sustaining information systems, for the promotion of an information culture, and for encouraging accountability in health systems. PMID:19304786

Introduction: Science, Sexuality, and Psychotherapy: Shifting Paradigms.

PubMed

Cerbone, Armand R

2017-08-01

This introduction presents an overview of the current issue (73, 8) of Journal of Clinical Psychology: In Session. This issue features a series of articles, with clinical cases, each presented to illustrate the challenges faced by individuals and couples whose sexual and gender identities and expressions do not comport with traditional and cultural norms. These articles also document the challenges to the therapists who treat them. Considered individually, each article underscores the need to recognize the importance of evidence in guiding psychotherapy in cases involving sexuality. The discussions in each article offer recommendations meant to help and guide psychotherapists. Considered collectively, they raise important questions and considerations about shifting paradigms of human sexuality. Implications for assessment and treatment of cases involving sexuality and gender identity are discussed and recommended. © 2017 Wiley Periodicals, Inc.

Moving Toward Paradigm-Shifting Research in Health Disparities Through Translational, Transformational, and Transdisciplinary Approaches

PubMed Central

Rhee, Kyu B.; Stoff, David M.; Pohlhaus, Jennifer Reineke; Sy, Francisco S.; Stinson, Nathaniel; Ruffin, John

2010-01-01

Translational, transdisciplinary, and transformational research stands to become a paradigm-shifting mantra for research in health disparities. A windfall of research discoveries using these 3 approaches has increased our understanding of the health disparities in racial, ethnic, and low socioeconomic status groups. These distinct but related research spheres possess unique environments, which, when integrated, can lead to innovation in health disparities science. In this article, we review these approaches and propose integrating them to advance health disparities research through a change in philosophical position and an increased emphasis on community engagement. We argue that a balanced combination of these research approaches is needed to inform evidence-based practice, social action, and effective policy change to improve health in disparity communities. PMID:20147662

Non-terrestrial origin of life: a transformative research paradigm shift.

PubMed

Wickramasinghe, N Chandra; Trevors, J T

2013-06-01

Theories and hypotheses in science are continually subject to verification, critical re-evaluation, revision and indeed evolution, in response to new observations and discoveries. Theories of the origin of life have been more constrained than other scientific theories and hypotheses in this regard, through the force of social and cultural pressures. There has been a tendency to adhere too rigidly to a class of theory that demands a purely terrestrial origin of life. For nearly five decades evidence in favour of a non-terrestrial origin of life and panspermia has accumulated which has not been properly assessed. A point has now been reached that demands the serious attention of biologists to a possibly transformative paradigm shift of the question of the origin of life, with profound implications across many disciplines.

Lambda Data Grid: Communications Architecture in Support of Grid Computing

DTIC Science & Technology

2006-12-21

number of paradigm shifts in the 20th century, including the growth of large geographically dispersed teams and the use of simulations and computational...get results. The work in this thesis automates the orchestration of networks with other resources, better utilizing all resources in a time efficient...domains, over transatlantic links in around minute. The main goal of this thesis is to build a new grid-computing paradigm that fully harnesses the

Building A Learning Pathway: An Interactive How-to Guide to Course Design

DTIC Science & Technology

2013-08-01

paradigm, a college professor’s primary task in the classroom was to deliver instruction – literally to profess his or her knowledge of a ... Instruction -Focused Paradigm to a Learning-Focused One There have been several factors that have led the higher education community to shift toward an...conceptions of teaching. Some faculty adopt an instruction -focused approach, with a conception of teaching principally as a matter of information

New Paradigm Shift for the Green Synthesis of Antibacterial Silver Nanoparticles Utilizing Plant Extracts

PubMed Central

2014-01-01

This review covers general information regarding the green synthesis of antibacterial silver nanoparticles. Owing to their antibacterial properties, silver nanoparticles are widely used in many areas, especially biomedical applications. In green synthesis practices, the chemical reducing agents are eliminated, and biological entities are utilized to convert silver ions to silver nanoparticles. Among the various biological entities, natural plant extracts have emerged as green reducing agents, providing eco-friendly routes for the preparation of silver nanomaterials. The most obvious merits of green synthesis are the increased biocompatibility of the resulting silver nanoparticles and the ease with which the reaction can be carried out. This review summarizes some of the plant extracts that are used to produce antibacterial silver nanoparticles. Additionally, background information regarding the green synthesis and antibacterial activity of silver nanoparticles is provided. Finally, the toxicological aspects of silver nanoparticles are briefly mentioned. PMID:25343010

HVDC Transmission an Outlook and Significance for Pakistani Power Sector

NASA Astrophysics Data System (ADS)

Ahmad, Muhammad; Wang, Zhixin; Wang, Jinjian; Baloach, Mazhar H.; Longxin, Bao; Hua, Qing

2018-04-01

Recently a paradigm shift in the power sector is observed, i.e., countries across the globe have deviated their attention to distributed generation rather than conventional centralized bulk generation. Owing to the above narrative, distributed energy resources e.g., wind and PV have gained the adequate attention of governments and researchers courtesy to their eco-friendly nature. On the contrary, the increased infiltration of distributed generation to the power system has introduced many technical and economical glitches such as long-distance transmission, transmission lines efficiency, control capability and cost etc. To mitigate these complications, the utility of high voltage direct current (HVDC) transmission has emerged as a possible solution. In this context, this paper includes a brief discussion on the fundamentals HVDC and its significance in Pakistani power sector. Furthermore, the potential of distributed energy resources for Pakistan is also the subject matter of this paper, so that significance of HVDC transmission can effectively be deliberated.

Praxis-based research networks: An emerging paradigm for research that is rigorous, relevant, and inclusive.

PubMed

Werner, James J; Stange, Kurt C

2014-01-01

Practice-based research networks (PBRNs) have developed a grounded approach to conducting practice-relevant and translational research in community practice settings. Seismic shifts in the health care landscape are shaping PBRNs that work across organizational and institutional margins to address complex problems. Praxis-based research networks combine PBRN knowledge generation with multistakeholder learning, experimentation, and application of practical knowledge. The catalytic processes in praxis-based research networks are cycles of action and reflection based on experience, observation, conceptualization, and experimentation by network members and partners. To facilitate co-learning and solution-building, these networks have a flexible architecture that allows pragmatic inclusion of stakeholders based on the demands of the problem and the needs of the network. Praxis-based research networks represent an evolving trend that combines the core values of PBRNs with new opportunities for relevance, rigor, and broad participation. © Copyright 2014 by the American Board of Family Medicine.

Knowledge networks for global public health.

PubMed

Natividad, Maria Dulce F; Fiereck, Kirk J; Parker, Richard

2012-01-01

The challenges posed by a globalised world have made it imperative for society to search for solutions to emerging issues and to develop new ways of looking at old problems. Current discussions about global public health demand a shift in paradigms and the strategic positioning of public health within broader policy discussions that will enable it to influence political and action agendas. Critical to responding to these challenges is the generation, transmission and dissemination of new knowledge to create value. Recognising the cutting-edge role of knowledge, as a new form of capital that drives innovation and transforms society, the formation of knowledge networks is viewed as a strategy for developing a shared intellectual, conceptual and ethical infrastructure for the field of global public health. These knowledge networks are envisioned as a vehicle for sharing diverse perspectives, encouraging debate and sustaining alternative ways of thinking about and responding to the challenges that confront global public health today and in the future.

Management of adult blunt hepatic trauma.

PubMed

Kozar, Rosemary A; McNutt, Michelle K

2010-12-01

To review the nonoperative and operative management of blunt hepatic injury in the adult trauma population. Although liver injury scale does not predict need for surgical intervention, a high-grade complex liver injury should alert the physician to a patient at increased risk of hepatic complications following nonoperative management. Blunt hepatic injury remains a frequent intraabdominal injury in the adult trauma population. The management of blunt hepatic injury has undergone a major paradigm shift from mandatory operative exploration to nonoperative management. Hemodynamic instability with a positive focused abdominal sonography for trauma and peritonitis are indications for emergent operative intervention. Although surgical intervention for blunt hepatic trauma is not as common as in years past, it is imperative that the current trauma surgeon be familiar with the surgical skill set to manage complex hepatic injuries. This study represents a review of both nonoperative and operative management of blunt hepatic injury.

Sexual Abuse in Cameroon: A Four-Year-Old Girl Victim of Rape in Buea Case Study.

PubMed

Chishugi, John; Franke, Trixy

2016-01-01

A young girl was brought to the emergency unit after suffering sexual abuse by an older male. Additional abuses against women and girls include physical beating, forced marriage, female genital mutilation, breast ironing, widow's rites, psychological abuse, and discrimination in education, finance, employment, and legal access. Cameroon has adopted strategies aimed at eliminating violence against women, including ratification of international policies, penal codes, and support of local and international efforts that promote women; however, many of the laws remain in name only and are rarely enforced, given women's lack of financial access to quality lawyers and an unsympathetic male-dominated police force. Underreporting and culturally accepted abuses remain a challenge, too, as the country seeks to understand the extent of abuses and how to effectively fight against them. A complete paradigm shift in cultural attitude toward the female gender is required for abuses to cease.

Federated and Cloud Enabled Resources for Data Management and Utilization

NASA Astrophysics Data System (ADS)

Rankin, R.; Gordon, M.; Potter, R. G.; Satchwill, B.

2011-12-01

The emergence of cloud computing over the past three years has led to a paradigm shift in how data can be managed, processed and made accessible. Building on the federated data management system offered through the Canadian Space Science Data Portal (www.cssdp.ca), we demonstrate how heterogeneous and geographically distributed data sets and modeling tools have been integrated to form a virtual data center and computational modeling platform that has services for data processing and visualization embedded within it. We also discuss positive and negative experiences in utilizing Eucalyptus and OpenStack cloud applications, and job scheduling facilitated by Condor and Star Cluster. We summarize our findings by demonstrating use of these technologies in the Cloud Enabled Space Weather Data Assimilation and Modeling Platform CESWP (www.ceswp.ca), which is funded through Canarie's (canarie.ca) Network Enabled Platforms program in Canada.

The Intestinal Microbiome in Infectious Diseases: The Clinical Relevance of a Rapidly Emerging Field.

PubMed

Harris, Vanessa C; Haak, Bastiaan W; Boele van Hensbroek, Michaël; Wiersinga, Willem J

2017-01-01

The field of infectious disease is undergoing a paradigm shift as the intestinal microbiome is becoming understood. The aim of this review is to inform infectious disease physicians of the potential relevance of the intestinal microbiome to their practice. We searched Medline using both index and text words relating to infectious diseases, microbiome, and probiotics. Relevant articles published up through 2017 were reviewed within Rayyan. The review illustrates pathophysiologic concepts linking the microbiome and infectious diseases; specifically, the intestinal microbiome's relevance to early immune development, the microbiome and enteric infections, the microbiome's relevance in compromised hosts, and antimicrobial resistance. Within each subject, there are specific examples of diseases and at-risk patient populations where a role for the microbiome has been strongly established. This provides an overview of the significance of the intestinal microbiome to microbiology, pediatric and adult infectious diseases with an underpinning of concepts useful for the practicing clinician.

[Homeostasis and Disorder of Musculoskeletal System.Progress in the treatment of rheumatoid arthritis.

PubMed

Tanaka, Yoshiya

Rheumatoid arthritis is a systemic autoimmune disease characterized by inflammation and joint damage that causes significant morbidity and mortality. Rapid and appropriate intervention using disease-modifying anti-rheumatic drugs(DMARDs)is prerequisite to halt joint destruction and long-term functional disabilities. Recent progress in the treatment strategy has brought about paradigm shift for the management of the disease, namely, the combined use of methotrexate, a synthetic DMARD, and a biologic DMARD targeting TNF, IL-6 and T cells has revolutionized treatment of rheumatoid arthritis. Clinical remission is now realistic targets for the treatment, achieved by a large proportion of rheumatoid arthritis patients, which leads to structural remission without damage in bone and cartilage as well as functional remission. Furthermore, orally available small but strong molecules targeting Janus kinase(JAK)are emerging. When DMARDs are prescribed, appropriate selection of DMARDs, adequate screening, regular monitoring and systemic management are required.

Endoscopic Management of Peri-Pancreatic Fluid Collections.

PubMed

Yip, Hon Chi; Teoh, Anthony Yuen Bun

2017-09-15

In the past decade, there has been a progressive paradigm shift in the management of peri-pancreatic fluid collections after acute pancreatitis. Refinements in the definitions of fluid collections from the updated Atlanta classification have enabled better communication amongst physicians in an effort to formulate optimal treatments. Endoscopic ultrasound (EUS)-guided drainage of pancreatic pseudocysts has emerged as the procedure of choice over surgical cystogastrostomy. The approach provides similar success rates with low complications and better quality of life compared with surgery. However, an endoscopic "step up" approach in the management of pancreatic walled-off necrosis has also been advocated. Both endoscopic and percutaneous drainage routes may be used depending on the anatomical location of the collections. New-generation large diameter EUS-specific stent systems have also recently been described. The device allows precise and effective drainage of the collections and permits endoscopic necrosectomy through the stents.

Perspectives of antiferromagnetic spintronics

NASA Astrophysics Data System (ADS)

Jungfleisch, Matthias B.; Zhang, Wei; Hoffmann, Axel

2018-04-01

Antiferromagnets are promising for future spintronic applications owing to their advantageous properties: They are magnetically ordered, but neighboring magnetic moments point in opposite directions, which results in zero net magnetization. This means antiferromagnets produce no stray fields and are insensitive to external magnetic field perturbations. Furthermore, they show intrinsic high frequency dynamics, exhibit considerable spin-orbit and magneto-transport effects. Over the past decade, it has been realized that antiferromagnets have more to offer than just being utilized as passive components in exchange bias applications. This development resulted in a paradigm shift, which opens the pathway to novel concepts using antiferromagnets for spin-based technologies and applications. This article gives a broad perspective on antiferromagnetic spintronics. In particular, the manipulation and detection of antiferromagnetic states by spintronics effects, as well as spin transport and dynamics in antiferromagnetic materials will be discussed. We will also outline current challenges and future research directions in this emerging field.

The Sponge Hologenome

PubMed Central

Thomas, Torsten

2016-01-01

ABSTRACT A paradigm shift has recently transformed the field of biological science; molecular advances have revealed how fundamentally important microorganisms are to many aspects of a host’s phenotype and evolution. In the process, an era of “holobiont” research has emerged to investigate the intricate network of interactions between a host and its symbiotic microbial consortia. Marine sponges are early-diverging metazoa known for hosting dense, specific, and often highly diverse microbial communities. Here we synthesize current thoughts about the environmental and evolutionary forces that influence the diversity, specificity, and distribution of microbial symbionts within the sponge holobiont, explore the physiological pathways that contribute to holobiont function, and describe the molecular mechanisms that underpin the establishment and maintenance of these symbiotic partnerships. The collective genomes of the sponge holobiont form the sponge hologenome, and we highlight how the forces that define a sponge’s phenotype in fact act on the genomic interplay between the different components of the holobiont. PMID:27103626

Macrophages: development and tissue specialization.

PubMed

Varol, Chen; Mildner, Alexander; Jung, Steffen

2015-01-01

Macrophages are myeloid immune cells that are strategically positioned throughout the body tissues, where they ingest and degrade dead cells, debris, and foreign material and orchestrate inflammatory processes. Here we review two major recent paradigm shifts in our understanding of tissue macrophage biology. The first is the realization that most tissue-resident macrophages are established prenatally and maintained through adulthood by longevity and self-renewal. Their generation and maintenance are thus independent from ongoing hematopoiesis, although the cells can be complemented by adult monocyte-derived macrophages. Second, aside from being immune sentinels, tissue macrophages form integral components of their host tissue. This entails their specialization in response to local environmental cues to contribute to the development and specific function of their tissue of residence. Factors that govern tissue macrophage specialization are emerging. Moreover, tissue specialization is reflected in discrete gene expression profiles of macrophages, as well as epigenetic signatures reporting actual and potential enhancer usage.

Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade

PubMed Central

2013-01-01

Although much advancement has been achieved in the treatment of chronic hepatitis B, antiviral resistance is still a challenging issue. Previous generation antiviral agents have already developed resistance in a number of patients, and it is still being used especially in resource limited countries. Once antiviral resistance occurs, it predisposes to subsequent resistance, resulting in multidrug resistance. Therefore, prevention of initial antiviral resistance is the most important strategy, and appropriate choice and modification of therapy would be the cornerstone in avoiding treatment failures. Until now, management of antiviral resistance has been evolving from sequential therapy to combination therapy. In the era of tenofovir, the paradigm shifts again, and we have to decide when to switch and when to combine on the basis of newly emerging clinical data. We expect future eradication of chronic hepatitis B virus infection by proper prevention and optimal management of antiviral resistance. PMID:24133659

Perspectives of antiferromagnetic spintronics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jungfleisch, Matthias B.; Zhang, Wei; Hoffmann, Axel

2018-04-01

Antiferromagnets are promising for future spintronics applications owing to their interesting properties: They are magnetically ordered, but neighboring magnetic moments point in opposite directions which results in zero net magneti- zation. This means antiferromagnets produce no stray fields and are insensitive to external magnetic field perturbations. Furthermore, they show intrinsic high frequency dynamics, exhibit considerable spin-orbit and magneto-transport effects. Over the past decade, it has been realized that antiferromagnets have more to offer than just being utilized as passive components in exchange bias applications. This development resulted in a paradigm shift, which opens the pathway to novel concepts using antiferromagnetsmore » for spin-based technologies and applications. This article gives a broad per- spective on antiferromagnetic spintronics. In particular, the manipulation and detection of anitferromagnetic states by spintronics effects, as well as spin transport and dynamics in antiferromagnetic materials will be discussed. We will also outline current challenges and future research directions in this emerging field.« less

Rethinking Hospital-Associated Deconditioning: Proposed Paradigm Shift

PubMed Central

Mangione, Kathleen K.; Stevens-Lapsley, Jennifer E.

2015-01-01

Physical therapists often treat older adults with marked deficits in physical function secondary to an acute hospitalization. These deficits are often collectively defined as hospital-associated deconditioning (HAD). However, there is a paucity of evidence that objectively demonstrates the efficacy of physical therapy for older adults with HAD. Older adults with HAD represent a highly variable and complex population and thus may be difficult to study and develop effective interventions for using our current rehabilitation strategies. This perspective article outlines an innovative framework to operationalize and treat older adults with HAD. This framework may help therapists apply emerging exercise strategies to this population and facilitate additional research to support the total value of physical therapy for older adults in postacute care settings—with value measured not only by improvements in physical performance but perhaps also by reduced rates of disability development, rehospitalization, and institutionalization. PMID:25908526

Pathophysiologic Mechanisms in Heart Failure: Role of the Sympathetic Nervous System.

PubMed

Antoine, Steve; Vaidya, Gaurang; Imam, Haider; Villarreal, Daniel

2017-01-01

The syndrome of heart failure involves complex pathophysiologic mechanisms and is associated with extremely high-morbidity, mortality and economic costs. This growing global epidemic has diverse etiologies and is fundamentally characterized by dyshomeostasis between heart and kidneys, leading to development and progression of the cardiorenal syndrome. Excessive and sustained sympathoexcitation has emerged as a single prominent factor involved in the structural and functional dysfunction of multiple organ systems during this disease. Studies in experimental models of heart failure indicate that ablation of the renal nerves may help restore renal sodium and water equilibrium as well as the attenuation of adverse cardiac remodeling. With the recent development of minimally invasive endovascular renal denervation in humans, it is anticipated that this technology would become a novel and important paradigm shift in the management of heart failure. Copyright © 2017. Published by Elsevier Inc.

E-learning in newborn health - a paradigm shift for continuing professional development for doctors and nurses.

PubMed

Chandrasekaran, Aparna; Thukral, Anu; Deorari, Ashok K

2014-12-01

Neonatal mortality can be largely prevented by wide-scale coverage of components of essential newborn care and management of sick neonates in district-level healthcare facilities. A vital step in this direction is imparting the requisite knowledge and skill among healthcare providers. Medical education programs with their static curricula seldom adapt to the changing needs of neonatal healthcare providers in patient-centered, collaborative and remote delivery contexts. E-learning is emerging as the cutting edge tool towards refinement of knowledge, attitude and practices of physicians. Module-based e-learning courses can be blended with a skill learning contact period in partnering institutions thus saving resources and rapidly covering a wide geographical region with uniform standardized education. In this review, the authors discuss their experience with e-learning aimed at introducing and refining the understanding of sick newborn care among pre-service and in-service doctors who manage neonates.

ECOSYSTEM MANAGEMENT: DESPERATELY SEEKING A PARADIGM

EPA Science Inventory

Two competing views of ecosystem management have emerged. One is that ecosystem management is another stage in the continual evolution of the basic management paradigm - one that natural resource managers have followed in North America for a century. The other view is that ecosys...

Shorter Versus Longer Shift Durations to Mitigate Fatigue and Fatigue-Related Risks in Emergency Medical Services Personnel and Related Shift Workers: A Systematic Review

DOT National Transportation Integrated Search

2018-01-11

Background: This study comprehensively reviewed the literature on the impact of shorter versus longer shifts on critical and important outcomes for Emergency Medical Services (EMS) personnel and related shift worker groups. Methods: Six databases (e....

Pediatric Bipolar Disorder in an Era of “Mindless Psychiatry”

PubMed Central

Parry, Peter I.; Levin, Edmund C.

2012-01-01

Objective Pediatric bipolar disorder (PBD) reflects shifts in conceptualizing bipolar disorder among children and adolescents since the mid-1990s. Since then, PBD diagnoses, predominantly in the United States, have increased dramatically, and the diagnosis has attracted significant controversy. During the same period, psychiatric theory and practice has become increasingly biological. The aim of this paper is to examine the rise of PBD in terms of wider systemic influences. Method In the context of literature referring to paradigm shifts in psychiatry, we reviewed the psychiatric literature, media cases, and information made available by investigative committees and journalists. Results Social historians and prominent psychiatrists describe a paradigm shift in psychiatry over recent decades: from an era of “brainless psychiatry,” when an emphasis on psychodynamic and family factors predominated to the exclusion of biological factors, to a current era of “mindless psychiatry” that emphasizes neurobiological explanations for emotional and behavioral problems with limited regard for contextual meaning. Associated with this has been a tendency within psychiatry and society to neglect trauma and attachment insecurity as etiological factors; the “atheoretical” (but by default biomedical) premise of the Diagnostic and Statistical Manual of Mental Disorders (3rd and 4th eds.); the influence of the pharmaceutical industry in research, continuing medical education, and direct-to-consumer advertising; and inequality in the U.S. health system that favors “diagnostic upcoding.” Harm from overmedicating children is now a cause of public concern. Conclusion It can be argued that PBD as a widespread diagnosis, particularly in the United States, reflects multiple factors associated with a paradigm shift within psychiatry rather than recognition of a previously overlooked common disorder. PMID:22211441

An engineering paradigm in the biomedical sciences: Knowledge as epistemic tool.

PubMed

Boon, Mieke

2017-10-01

In order to deal with the complexity of biological systems and attempts to generate applicable results, current biomedical sciences are adopting concepts and methods from the engineering sciences. Philosophers of science have interpreted this as the emergence of an engineering paradigm, in particular in systems biology and synthetic biology. This article aims at the articulation of the supposed engineering paradigm by contrast with the physics paradigm that supported the rise of biochemistry and molecular biology. This articulation starts from Kuhn's notion of a disciplinary matrix, which indicates what constitutes a paradigm. It is argued that the core of the physics paradigm is its metaphysical and ontological presuppositions, whereas the core of the engineering paradigm is the epistemic aim of producing useful knowledge for solving problems external to the scientific practice. Therefore, the two paradigms involve distinct notions of knowledge. Whereas the physics paradigm entails a representational notion of knowledge, the engineering paradigm involves the notion of 'knowledge as epistemic tool'. Copyright © 2017 Elsevier Ltd. All rights reserved.

Covert Shifts of Spatial Attention in the Macaque Monkey

PubMed Central

Caspari, Natalie; Janssens, Thomas; Mantini, Dante; Vandenberghe, Rik

2015-01-01

In the awake state, shifts of spatial attention alternate with periods of sustained attention at a fixed location or object. Human fMRI experiments revealed the critical role of the superior parietal lobule (SPL) in shifting spatial attention, a finding not predicted by human lesion studies and monkey electrophysiology. To investigate whether a potential homolog of the human SPL shifting region exists in monkeys (Macaca mulatta), we adopted an event-related fMRI paradigm that closely resembled a human experiment (Molenberghs et al., 2007). In this paradigm, a pair of relevant and irrelevant shapes was continuously present on the horizontal meridian. Subjects had to covertly detect a dimming of the relevant shape while ignoring the irrelevant dimmings. The events of interest consisted of the replacement of one stimulus pair by the next. During shift but not stay events, the relevant shape of the new pair appeared at the contralateral position relative to the previous one. Spatial shifting events activated parietal areas V6/V6A and medial intraparietal area, caudo-dorsal visual areas, the most posterior portion of the superior temporal sulcus, and several smaller frontal areas. These areas were not activated during passive stimulation with the same sensory stimuli. During stay events, strong direction-sensitive attention signals were observed in a distributed set of contralateral visual, temporal, parietal, and lateral prefrontal areas, the vast majority overlapping with the sensory stimulus representation. We suggest medial intraparietal area and V6/V6A as functional counterparts of human SPL because they contained the most widespread shift signals in the absence of contralateral stay activity, resembling the functional characteristics of the human SPL shifting area. PMID:25995460

Impact of nutrition interventions on pediatric mortality and nutrition outcomes in humanitarian emergencies: A systematic review.

PubMed

Balhara, Kamna S; Silvestri, David M; Tyler Winders, W; Selvam, Anand; Kivlehan, Sean M; Becker, Torben K; Levine, Adam C

2017-12-01

Malnutrition contributes to paediatric morbidity and mortality in disasters and complex emergencies, but summary data describing specific nutritional interventions in these settings are lacking. This systematic review aimed to characterise such interventions and their effects on paediatric mortality, anthropometric measures and serum markers of nutrition. A systematic search of OVID MEDLINE, Cochrane Library and relevant grey literature was conducted. We included all randomised controlled trials and observational controlled studies evaluating effectiveness of nutritional intervention(s) on defined health outcomes in children and adolescents (0-18 years) within a disaster or complex emergency. We extracted study characteristics, interventions and outcomes data. Study quality was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. A total of 31 studies met inclusion criteria. Most were conducted in Africa (17), during periods of conflict or hunger gaps (14), and evaluated micronutrient supplementation (14) or selective feeding (10). Overall study quality was low, with only two high and four moderate quality studies. High- and medium-quality studies demonstrated positive impact of fortified spreads, ready-to-use therapeutic foods, micronutrient supplementation, and food and cash transfers. In disasters and complex emergencies, high variability and low quality of controlled studies on paediatric malnutrition limit meaningful data aggregation. If existing research gaps are to be addressed, the inherent unpredictability of humanitarian emergencies and ethical considerations regarding controls may warrant a paradigm shift in what constitutes adequate methods. Periodic hunger gaps may offer a generalisable opportunity for robust trials, but consensus on meaningful nutritional endpoints is needed. © 2017 John Wiley & Sons Ltd.

Exploring New Metrics for Education 3.0: Opportunities and Challenges for Shifting Assessment Practice at Te Kura

ERIC Educational Resources Information Center

Hipkins, Rosemary; Bolstad, Rachel; Johnson, Cathie

2015-01-01

The phrase "Education 3.0" is used to signal a complex and still-evolving paradigm shift from the traditional schooling models of the 19th and 20th centuries (Education 1.0), via an intensified focus on teachers' and school leaders' accountabilities in relation to students' learning (Education 2.0), towards a more holistic model of…

My School, My Self: It's Time for the Paradigm Shift to Actually Shift

ERIC Educational Resources Information Center

Blodget, Alden S.

2016-01-01

As is becoming increasingly clear from research into the role of emotion in learning, people think and learn about what matters to them. This article discusses why the purpose of education ought to be to help students figure out who they are and what the world means to them. This is how they become productive, moral citizens of the world.…

A paradigm shift in biomass technology from complete to partial cellulose hydrolysis: lessons learned from nature.

PubMed

Chen, Rachel

2015-01-01

A key characteristic of current biomass technology is the requirement for complete hydrolysis of cellulose and hemicellulose, which stems from the inability of microbial strains to use partially hydrolyzed cellulose, or cellodextrin. The complete hydrolysis paradigm has been practiced over the past 4 decades with major enzyme companies perfecting their cellulase mix for maximal yield of monosaccharides, with corresponding efforts in strain development focus almost solely on the conversion of monosaccharides, not cellodextrin, to products. While still in its nascent infancy, a new paradigm requiring only partial hydrolysis has begun to take hold, promising a shift in the biomass technology at its fundamental core. The new paradigm has the potential to reduce the requirement for cellulase enzymes in the hydrolysis step and provides new strategies for metabolic engineers, synthetic biologists and alike in engineering fermenting organisms. Several recent publications reveal that microorganisms engineered to metabolize cellodextrins, rather than monomer glucose, can reap significant energy gains in both uptake and subsequent phosphorylation. These energetic benefits can in turn be directed for enhanced robustness and increased productivity of a bioprocess. Furthermore, the new cellodextrin metabolism endows the biocatalyst the ability to evade catabolite repression, a cellular regulatory mechanism that is hampering rapid conversion of biomass sugars to products. Together, the new paradigm offers significant advantages over the old and promises to overcome several critical barriers in biomass technology. More research, however, is needed to realize these promises, especially in discovery and engineering of cellodextrin transporters, in developing a cost-effective method for cellodextrin generation, and in better integration of cellodextrin metabolism to endogenous glycolysis.

Symmetry and Asymmetry: New Contours, Paradigms, and Politics in African Academic Partnerships

ERIC Educational Resources Information Center

Obamba, Milton Odhiambo; Mwema, Jane Kimbwarata

2009-01-01

International partnership spanning various organizational and geographical boundaries has emerged as the dominant paradigm for organizing modern scientific research; and for undertaking international development policy. Academic collaboration has become ubiquitous, embedded in organizational cultures, and is increasingly organized in a wide…

Emergent Behavior in the Macro World: Rigidity of Granular Solids

NASA Astrophysics Data System (ADS)

Chakraborty, Bulbul

2015-03-01

Diversity in the natural world emerges from the collective behavior of large numbers of interacting objects. The origin of collectively organized structures over the vast range of length scales from the subatomic to colloidal is the competition between energy and entropy. Thermal motion provides the mechanism for organization by allowing particles to explore the space of configurations. This well-established paradigm of emergent behavior breaks down for collections of macroscopic objects ranging from grains of sand to asteroids. In this macro-world of particulate systems, thermal motion is absent, and mechanical forces are all important. We lack understanding of the basic, unifying principles that underlie the emergence of order in this world. In this talk, I will explore the origin of rigidity of granular solids, and present a new paradigm for emergence of order in these athermal systems. This work has been supported by NSF-DMR 1409093 and by the W. M. Keck foundation

New paradigm for drug developments--from emerging market statistical perspective.

PubMed

Quan, Hui; Chen, Xun; Zhang, Ji; Zhao, Peng-Liang

2013-11-01

Paradigm for new drug development has changed dramatically over the last decade. Even though new technology increases efficiency in many aspects, partially due to much more stringent regulatory requirements, it actually now takes longer and costs more to develop a new drug. To deal with challenge, some initiatives are taken by the pharmaceutical industry. These initiatives include exploring emerging markets, conducting global trials and building research and development centers in emerging markets to curb spending. It is particularly the current trend that major pharmaceutical companies offshore a part of their biostatistical support to China. In this paper, we first discuss the skill set for trial statisticians in the new era. We then elaborate on some of the approaches for acquiring statistical talent and capacity in general, particularly in emerging markets. We also make some recommendations on the use of the PDUFA strategy and collaborations among industry, health authority and academia from emerging market statistical perspective. © 2013.

On emergence: a neo-psychoanalytic essay on change and science.

PubMed

Whitehead, Clay C

2011-01-01

The neo-psychoanalytic paradigm re-establishes the connection between psychodynamics and evolution. This allows us to transcend the limitations of dualistic metapsychology, and to make seminal contributions to traditional science. The new paradigm employs the concept of emergence, the potential for change in the evolutionary and clinical process. Emergence is described as originating with the Big Bang, but also is reflected at much higher levels, for example, biochemistry, or the capacity of the evolved mind to produce insights in psychotherapy. The constraints of dualistic theories are examined. A neuron-based view of change illustrates the evolution of traditional science as well as the neuron, itself. The new mind paradigm recognizes individual, familial, communitarian, and global reciprocal influences mediated by culture and illustrated by the extended mind and the democratic spirit. Thus both traditional and psychodynamic sciences are undergoing revolutionary changes in their common efforts to better understand the mechanisms of knowledge, relationship and consciousness. The boundaries of the self and the consultation suite are also expanded in this view. Following a survey of invagination, the work is concluded by an application of emergence theory to the creationist controversy and Freud's views of religion.

RNA as an Astrophysical or Geophysical Document?? Correlated issues in nebular and planetary astronomy, geology and biology

NASA Astrophysics Data System (ADS)

Hill, L. C.

1999-12-01

The emergence of the largely silicate earth from a presumably cosmically normal, H-rich solar nebula 4.5 eons ago is an obviously important issue relevant to many disciplines of the physical sciences. The emergence of terrestrial life is an equally important issue for biological sciences. Recent discoveries of isotopically light carbon (i.e. putative chemical fossils) in 3.85+ Ga Issua, Greenland sediments have reopened the issue of whether terrestrial life may have emerged prior to the earliest known rocks so that one might use biological records to deduce early terrestrial environments. In addition, recent advances in molecular genetics have suggested that all known ancestral life forms passed through an early hydrogen-rich environment which is more consistent with the now rejected Urey hypothesis of a early jovian atmosphere than with contemporary geological and planetological paradigms. In this essay, then, we examine possible limitations of contemporary paradigms of planetary science since a prima facie case will be made that life could not emerge in those environments which those paradigms now allow. Of necessity, the discussion will also address some hidden conflicts embedded in various disciplinary methodologies (e.g. astronomy, biology, geology).

Peto's paradox and the promise of comparative oncology

PubMed Central

Nunney, Leonard; Maley, Carlo C.; Breen, Matthew; Hochberg, Michael E.; Schiffman, Joshua D.

2015-01-01

The past several decades have seen a paradigm shift with the integration of evolutionary thinking into studying cancer. The evolutionary lens is most commonly employed in understanding cancer emergence, tumour growth and metastasis, but there is an increasing realization that cancer defences both between tissues within the individual and between species have been influenced by natural selection. This special issue focuses on discoveries of these deeper evolutionary phenomena in the emerging area of ‘comparative oncology’. Comparing cancer dynamics in different tissues or species can lead to insights into how biology and ecology have led to differences in carcinogenesis, and the diversity, incidence and lethality of cancers. In this introduction to the special issue, we review the history of the field and outline how the contributions use empirical, comparative and theoretical approaches to address the processes and patterns associated with ‘Peto's paradox’, the lack of a statistical relationship of cancer incidence with body size and longevity. This burgeoning area of research can help us understand that cancer is not only a disease but is also a driving force in biological systems and species life histories. Comparative oncology will be key to understanding globally important health issues, including cancer epidemiology, prevention and improved therapies. PMID:26056361

Epidemiology of Group B Streptococcal Disease in the United States: Shifting Paradigms

PubMed Central

Schuchat, Anne

1998-01-01

Since its emergence 25 years ago, group B streptococcus has become recognized as a cause of serious illness in newborns, pregnant women, and adults with chronic medical conditions. Heavy colonization of the genital tract with group B streptococcus also increases the risk that a woman will deliver a preterm low-birthweight infant. Early-onset infections (occurring at <7 days of age) are associated with much lower fatality than when they were first described, and their incidence is finally decreasing as the use of preventive antibiotics during childbirth increases among women at risk. New serotypes of group B streptococcus have emerged as important pathogens in adults and newborns. Clinical and laboratory practices—in obstetrics, pediatrics, and clinical microbiology—have an impact on disease and/or its prevention, and protocols established at the institutional level appear to be critical tools for the reduction of perinatal disease due to group B streptococcus. Since intrapartum antibiotics will prevent at best only a portion of the full burden of group B streptococcal disease, critical developments in vaccine evaluation, including study of polysaccharide-protein conjugate vaccines, offer the potential for enhanced prevention in the relatively near future. PMID:9665980

Risky Play and Children’s Safety: Balancing Priorities for Optimal Child Development

PubMed Central

Brussoni, Mariana; Olsen, Lise L.; Pike, Ian; Sleet, David A.

2012-01-01

Injury prevention plays a key role in keeping children safe, but emerging research suggests that imposing too many restrictions on children’s outdoor risky play hinders their development. We explore the relationship between child development, play, and conceptions of risk taking with the aim of informing child injury prevention. Generational trends indicate children’s diminishing engagement in outdoor play is influenced by parental and societal concerns. We outline the importance of play as a necessary ingredient for healthy child development and review the evidence for arguments supporting the need for outdoor risky play, including: (1) children have a natural propensity towards risky play; and, (2) keeping children safe involves letting them take and manage risks. Literature from many disciplines supports the notion that safety efforts should be balanced with opportunities for child development through outdoor risky play. New avenues for investigation and action are emerging seeking optimal strategies for keeping children “as safe as necessary,” not “as safe as possible.” This paradigm shift represents a potential for epistemological growth as well as cross-disciplinary collaboration to foster optimal child development while preserving children’s safety. PMID:23202675

Management of hyperkalaemia in chronic kidney disease.

PubMed

Kovesdy, Csaba P

2014-11-01

Hyperkalaemia is common in patients with chronic kidney disease (CKD), in part because of the effects of kidney dysfunction on potassium homeostasis and in part because of the cluster of comorbidities (and their associated treatments) that occur in patients with CKD. Owing to its electrophysiological effects, severe hyperkalaemia represents a medical emergency that usually requires prompt intervention, whereas the prevention of hazardous hyperkalaemic episodes in at-risk patients requires measures aimed at the long-term normalization of potassium homeostasis. The options for effective and safe medical interventions to restore chronic potassium balance are few, and long-term management of hyperkalaemia is primarily limited to the correction of modifiable exacerbating factors. This situation can result in a difficult trade-off in patients with CKD, because drugs that are beneficial to these patients (for example, renin-angiotensin-aldosterone-system antagonists) are often the most prominent cause of their hyperkalaemia. Maintaining the use of these beneficial medications while implementing various strategies to control potassium balance is desirable; however, discontinuation rates remain high. The emergence of new medications that specifically target hyperkalaemia could lead to a therapeutic paradigm shift, emphasizing preventive management over ad hoc treatment of incidentally discovered elevations in serum potassium levels.

Environment and Architecture - a Paradigm Shift

NASA Astrophysics Data System (ADS)

di Battista, Valerio

The interaction of human cultures and the built environment allows a wide range of interpretations and has been studied inside the domain of many disciplines. This paper discusses three interpretations descending from a systemic approach to the question: - architecture as an "emergence" of the settlement system; - place (and space) as an "accumulator" of time and a "flux" of systems; - landscape as one representation/description of the human settlement. Architecture emerges as a new physical conformation or layout, or as a change in a specific site, arising from actions and representations of political, religious, economical or social powers, being shaped at all times by the material culture belonging to a specific time and place in the course of human evolution. Any inhabited space becomes over time a place as well as a landscape, i.e. a representation of the settlement and a relationship between setting and people. Therefore, any place owns a landscape which, in turn, is a system of physical systems; it could be defined as a system of sites that builds up its own structure stemming from the orographical features and the geometry of land surfaces that set out the basic characters of its space.

The Road to Realizing In-Space Manufacturing

NASA Technical Reports Server (NTRS)

Clinton, Raymond G.

2014-01-01

Additive Manufacturing in space offers tremendous potential for dramatic paradigm shift in the development and manufacturing of space architectures. Additive Manufacturing in space offers the potential for mission safety risk reduction for low Earth orbit and deep space exploration; new paradigms for maintenance, repair, and logistics. Leverage ground-based technology developments, process characterization, and material properties databases. Investments are required primarily in the microgravity environment. We must do the foundational work. It's not sexy, but it is required.

Where you stand depends on where you sit: Qualitative inquiry into notions of fire adaptation

Treesearch

Hannah Brenkert-Smith; James R. Meldrum; Patricia A. Champ; Christopher M. Barth

2017-01-01

Wildfire and the threat it poses to society represents an example of the complex, dynamic relationship between social and ecological systems. Increasingly, wildfire adaptation is posited as a pathway to shift the approach to fire from a suppression paradigm that seeks to control fire to a paradigm that focuses on “living with” and “adapting to” wildfire. In this study...

Language Research Center's Computerized Test System (LRC-CTS) - Video-formatted tasks for comparative primate research

NASA Technical Reports Server (NTRS)

Rumbaugh, Duane M.; Washburn, David A.; Savage-Rumbaugh, E. S.; Hopkins, William D.; Richardson, W. K.

1991-01-01

Automation of a computerized test system for comparative primate research is shown to improve the results of learning in standard paradigms. A mediational paradigm is used to determine the degree to which criterion in the learning-set testing reflects stimulus-response associative or mediational learning. Rhesus monkeys are shown to exhibit positive transfer as the criterion levels are shifted upwards, and the effectiveness of the computerized testing system is confirmed.

Paradigm shifts about dust on the Moon: From Apollo 11 to Chang'e-4

NASA Astrophysics Data System (ADS)

O'Brien, Brian J.

2018-07-01

Strategic purposes of this DAP-2017 report are to update our DAP-2010 report on movements of inescapable fine lunar dust, to summarise key new measurements and to assist rigorous focus. Lunar dust is defined here in two sciences, Apollo dust and Ejecta dust, to end several confusions. The Kuhn Cycle is introduced to stimulate progression of a science about movements of Apollo dust which lacks an agreed paradigm to supply puzzles for scientists to solve and tools for their solution. We populate the cycle with two paradigm shifts. The first was serendipitous invention in 1966 of the Apollo Dust Detector Experiment (DDE), 3 orthogonal solar cells each with a thermometer, which on Apollo 12 measured cause and effect, collective movements of billions to trillions of low-energy Apollo dust particles and changes in temperature they cause. In contrast, Apollo 17 LEAM and LADEE LDEX experiments follow traditions to measure impacts of high-velocity Ejecta dust particles, one by one. In 2015, Apollo 12 DDE discoveries of sunrise-driven storms of Apollo dust stimulated a measurement-based 5-step model of dust transport at astronaut waist height. The discoveries solve (i) 50-year-old mysteries of Horizon Glow, (ii) 30-year-old uncertainties about levitated dust, (iii) processes leading to lunar surfaces being smooth and (iv) immobilisation of the Chang'e-3 lunar rover Yutu in 2014 after its first sunrise. The IAC-2017 Website Abstract of a withdrawn Chang'e-3 presentation may support our views that sunrise-mobilised dust caused immobilisation of Yutu. A precursor to a second paradigm shift was May 2016 announced revision of Chang'e-4 scientific priorities. Using Kuhn terminology of scientific progress, a second shift would follow our "revolution" in 2015 that sunrise-driven dust storms caused the 2014 ″crisis" of immobilisation of Chang'e-3 lunar rover Yutu. No such sequence occurred previously with lunar dust. Measurement-based evidence from Apollo 11 to Chang'e-3 confirms that Apollo dust is the major surface problem for risk management plans of lunar expeditions. As of 1 February 2018, a second paradigm change awaits transparent authoritative Ground truth measurements by Chang'e-4 or other relevant dust detectors to compare with Apollo 12 DDE measurements. Re-examination of risk management of effects of Apollo dust is essential for international expeditions including a Moon Village and Google Lunar XMedal competitors. Future DAPs could refine a third paradigm shift for Moon, moving from the past and present Earth-centric cultures of an inert Moon to cultures with visions of Moon as an active and close Extraterrestrial neighbour, because its outermost sunlit two cm of dusty plasmas are a variable soup of lunar and Extraterrestrial plasmas. An emphasis on its research seems a neat fit with the Directive of President Trump on 11 December 2017 to "Lead an innovative and sustainable program of exploration with commercial and international partners" to "lead the return of humans to the Moon for long-term exploration and utilization". It would also be measurement-based now thus less costly, more safe and quicker than any human visit to Mars.

Modeling Hourly Resident Productivity in the Emergency Department.

PubMed

Joseph, Joshua W; Henning, Daniel J; Strouse, Connie S; Chiu, David T; Nathanson, Larry A; Sanchez, Leon D

2017-08-01

Resident productivity, defined as new patients per hour, carries important implications for emergency department operations. In high-volume academic centers, essential staffing decisions can be made on the assumption that residents see patients at a static rate. However, it is unclear whether this model mirrors reality; previous studies have not rigorously examined whether productivity changes over time. We examine residents' productivity across shifts to determine whether it remained consistent. This was a retrospective cohort study conducted in an urban academic hospital with a 3-year emergency medicine training program in which residents acquire patients ad libitum throughout their shift. Time stamps of all patient encounters were automatically logged. A linear mixed model was constructed to predict productivity per shift hour. A total of 14,364 8- and 9-hour shifts were worked by 75 residents between July 1, 2010, and June 20, 2015. This comprised 6,127 (42.7%) postgraduate year (PGY) 1 shifts, 7,236 (50.4%) PGY-2 shifts, and 998 (6.9%) PGY-3 nonsupervisory shifts (Table 1). Overall, residents treated a mean of 10.1 patients per shift (SD 3.2), with most patients at Emergency Severity Index level 3 or more acute (93.8%). In the initial hour, residents treated a mean of 2.14 patients (SD 1.2), and every subsequent hour was associated with a significant decrease, with the largest in the second, third, and final hours. Emergency medicine resident productivity during a single shift follows a reliable pattern that decreases significantly hourly, a pattern preserved across PGY years and types of shifts. This suggests that resident productivity is a dynamic process, which should be considered in staffing decisions and studied further. Copyright © 2016 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

Effects of Alcohol on Tests of Executive Functioning in Men and Women: A Dose Response Examination

PubMed Central

Guillot, Casey R.; Fanning, Jennifer R.; Bullock, Joshua S.; McCloskey, Michael S.; Berman, Mitchell E.

2014-01-01

Alcohol has been shown to affect performance on tasks associated with executive functioning. However, studies in this area have generally been limited to a single dose or gender or have used small sample sizes. The purpose of this study was to provide a more nuanced and systematic examination of alcohol's effects on commonly used tests of executive functioning at multiple dosages in both men and women. Research volunteers (91 women and 94 men) were randomly assigned to one of four drink conditions (alcohol doses associated with target blood alcohol concentrations of .000%, .050%, .075% and .100%). Participants then completed three tasks comprising two domains of executive functioning: two set shifting tasks, the Trail Making Test and a computerized version of the Wisconsin Card Sorting Task, and a response inhibition task, the GoStop Impulsivity Paradigm. Impaired performance on set shifting tasks was found at the .100% and .075% dosages, but alcohol intoxication did not impair performance on the GoStop. No gender effects emerged. Thus, alcohol negatively affects set shifting at moderately high levels of intoxication in both men and women, likely due to alcohol's interference with prefrontal cortex function. Although it is well-established that alcohol negatively affects response inhibition as measured by auditory stop-signal tasks, alcohol does not appear to exert a negative effect on response inhibition as measured by the GoStop, a visual stop-signal task. PMID:20939644

Perspectives on Emerging/Novel Computing Paradigms and Future Aerospace Workforce Environments

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

2003-01-01

The accelerating pace of the computing technology development shows no signs of abating. Computing power reaching 100 Tflop/s is likely to be reached by 2004 and Pflop/s (10(exp 15) Flop/s) by 2007. The fundamental physical limits of computation, including information storage limits, communication limits and computation rate limits will likely be reached by the middle of the present millennium. To overcome these limits, novel technologies and new computing paradigms will be developed. An attempt is made in this overview to put the diverse activities related to new computing-paradigms in perspective and to set the stage for the succeeding presentations. The presentation is divided into five parts. In the first part, a brief historical account is given of development of computer and networking technologies. The second part provides brief overviews of the three emerging computing paradigms grid, ubiquitous and autonomic computing. The third part lists future computing alternatives and the characteristics of future computing environment. The fourth part describes future aerospace workforce research, learning and design environments. The fifth part lists the objectives of the workshop and some of the sources of information on future computing paradigms.

Changing the paradigms of treatment in peripheral T-cell lymphoma: from biology to clinical practice.

PubMed

O'Connor, Owen A; Bhagat, Govind; Ganapathi, Karthik; Pedersen, Martin Bjerregaard; D'Amore, Francesco; Radeski, Dejan; Bates, Susan E

2014-10-15

Despite enormous advances in our understanding of aggressive lymphomas, it is clear that progress in the peripheral T-cell lymphomas (PTCL) has lagged well behind other B-cell malignancies. Although there are many reasons for this, the one commonly cited notes that the paradigms for diffuse large B-cell lymphoma (DLBCL) were merely applied to all patients with PTCL, the classic "one-size-fits-all" approach. Despite these challenges, progress is being made. Recently, the FDA has approved four drugs for patients with relapsed/refractory PTCL over the past 5 years, and if one counts the recent Japanese approval of the anti-CCR4 monoclonal antibody for patients with adult T-cell leukemia/lymphoma, five drugs have been approved worldwide. These efforts have led to the initiation of no fewer than four randomized clinical studies exploring the integration of these new agents into standard CHOP (cyclophosphamide-Adriamycin-vincristine-prednisone)-based chemotherapy regimens for patients with newly diagnosed PTCL. In addition, a new wave of studies are exploring the merits of novel drug combinations in the disease, an effort to build on the obvious single-agent successes. What has emerged most recently is the recognition that the PTCL may be a disease-characterized by epigenetic dysregulation, which may help explain its sensitivity to histone deacetylase (HDAC) inhibitors, and open the door for even more creative combination approaches. Nonetheless, advances made over a relatively short period of time are changing how we now view these diseases and, hopefully, have poised us to finally improve its prognosis. See all articles in this CCR Focus section, "Paradigm Shifts in Lymphoma." ©2014 American Association for Cancer Research.

Incorporating healthcare informatics into the strategic planning process in nursing education.

PubMed

Sackett, Kay; Jones, Janice; Erdley, W Scott

2005-01-01

The purpose of this article is to describe the incorporation of healthcare informatics into the strategic planning process in nursing education. An exemplar from the University at Buffalo, the State University of New York School of Nursing, is interwoven throughout the article. The challenges and successes inherent in a paradigm shift embracing the multifaceted adoption of technology in higher education are illustrated. The paradigm shift that necessitated this change, the need for informatics standards and competencies identified by regulatory agencies and the relationship of the triad mission of the Academy which includes research, teaching and service are then elucidated. Information pertinent to the strategic planning process is described including the use of a strengths, weaknesses, opportunities and threats (SWOT) analysis to facilitate the integration of a healthcare informatics model into a nursing curriculum.

Troublesome times demand more effective practices.

PubMed

Botkin, Mary; Felton, Ken

2009-01-01

The intensifying financial pressures bearing down on the American government and taxpayers due to egregious corporate mismanagement will focus increasing and unprecedented scrutiny on the business world. The risk management community believes a paradigm shift is at hand. Organizations of every kind will feel pressure to do more than they have in the past to understand the risks they face, expose and challenge every assumption they make, and take steps to quantify and appropriately mitigate the exposures they identify. This will not be an easy transition. Just as the healthcare community has struggled over the past 25 years with the paradigm shift from the unsystematic clinical experience to a more analytical, evidence-based approach, the corporate world will have to move from a traditional silo-centric risk management system to a more formalized, analytical, enterprise-wide risk management competency.

When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics

PubMed Central

Wang, Hann; Silva, Aleidy; Ho, Chih-Ming

2013-01-01

During the last two decades, the manufacturing techniques of microfluidics-based devices have been phenomenally advanced, offering unlimited potential for bio-medical technologies. However, the direct applications of these technologies toward diagnostics and therapeutics are still far from maturity. The present challenges lay at the interfaces between the engineering systems and the biocomplex systems. A precisely designed engineering system with narrow dynamic range is hard to seamlessly integrate with the adaptive biological system in order to achieve the design goals. These differences remain as the roadblock between two fundamentally non-compatible systems. This paper will not extensively review the existing microfluidic sensors and actuators; rather, we will discuss the sources of the gaps for integration. We will also introduce system interface technologies for bridging the differences to lead toward paradigm shifts in diagnostics and therapeutics. PMID:26835672

Use of dextran nanoparticle: A paradigm shift in bacterial exopolysaccharide based biomedical applications.

PubMed

Banerjee, Aparna; Bandopadhyay, Rajib

2016-06-01

This review is a concise compilation of all the major researches on dextran nanoparticle based biomedical applications. Dextran is a highly biocompatible and biodegradable neutral bacterial exopolysaccharide with simple repeating glucose subunits. It's simple yet unique biopolymeric nature made it highly suitable as nanomedicine, nanodrug carrier, and cell imaging system or nanobiosensor. Most importantly, it is extremely water soluble and shows no post drug delivery cellular toxicity. Complete metabolism of dextran is possible inside body thus possibility of renal failure is minimum. Dextran based nanoparticles have superior aqueous solubility, high cargo capacity and intrinsic viscosity, and short storage period. The main focus area of this review is- past and present of major biomedical applications of dextran based nanomaterials thus showing a paradigm shift in bacterial exopolysaccharide based nanobiotechnology. Copyright © 2016 Elsevier B.V. All rights reserved.

Accelerating Harmonization in Digital Health.

PubMed

Moore, Carolyn; Werner, Laurie; BenDor, Amanda Puckett; Bailey, Mike; Khan, Nighat

2017-01-01

Digital tools play an important role in supporting front-line health workers who deliver primary care. This paper explores the current state of efforts undertaken to move away from single-purpose applications of digital health towards integrated systems and solutions that align with national strategies. Through examples from health information systems, data and health worker training, this paper demonstrates how governments and stakeholders are working to integrate digital health services. We emphasize three factors as crucial for this integration: development and implementation of national digital health strategies; technical interoperability and collaborative approaches to ensure that digital health has an impact on the primary care level. Consolidation of technologies will enable an integrated, scaleable approach to the use of digital health to support health workers. As this edition explores a paradigm shift towards harmonization in primary healthcare systems, this paper explores complementary efforts undertaken to move away from single-purpose applications of digital health towards integrated systems and solutions that align with national strategies. It describes a paradigm shift towards integrated and interoperable systems that respond to health workers' needs in training, data and health information; and calls for the consolidation and integration of digital health tools and approaches across health areas, functions and levels of the health system. It then considers the critical factors that must be in place to support this paradigm shift. This paper aims not only to describe steps taken to move from fractured pilots to effective systems, but to propose a new perspective focused on consolidation and collaboration guided by national digital health strategies.

Creating a new generation of pediatric dentists: a paradigm shift in training.

PubMed

Ramos-Gomez, Francisco J; Silva, Daniela Rodrigues P; Law, Clarice S; Pizzitola, Rebecca L; John, Brendan; Crall, James J

2014-12-01

The University of California, Los Angeles (UCLA) School of Dentistry has implemented a Health Resources and Services Administration-funded program to prepare dentists for the complex and comprehensive needs of pediatric patients within rapidly changing demographics and a paradigm shift in dentistry. Traditional dental education has focused on how to respond to oral disease, whereas UCLA's program shifts the paradigm to emphasize early assessment, risk-based prevention, and disease management. A holistic approach to dental care that considers social and environmental determinants is used with minimally invasive techniques for restorative care. To support this change, pediatric dental residents receive traditional training combined with new didactics, advocacy opportunities, and applied learning experiences at community-based organizations. These new elements teach residents to recognize the causal factors of disease and to identify interventions that promote oral health at the individual, family, community, and policy level. Consequently, they are better prepared to treat a diverse group of patients who historically have faced the greatest burden of disease as well as an increased number of barriers to accessing oral health care; these consist of low-income, minority, and/or pediatric populations including children with special health needs. The program's ultimate goal is for residents to deploy these skills in treating vulnerable populations and to demonstrate greater interest in collaborating with non-dental health providers and community organizations to increase access to dental services in private or public health practice settings.

Improving Malaria Control in West Africa: Interruption of Transmission as a Paradigm Shift

PubMed Central

Doumbia, Seydou O.; Ndiaye, Daouda; Koita, Ousmane A.; Diakité, Mahamadou; Nwakanma, Davis; Coulibaly, Mamadou; Traoré, Sekou F.; Keating, Joseph; Milner, Danny A.; Ndiaye, Jean-Louis; Sene, Papa Diogoye; Ahouidi, Ambroise; Dieye, Tandakha N.; Gaye, Oumar; Okebe, Joseph; Ceesay, Serign J.; Ngwa, Alfred; Oriero, Eniyou C.; Konaté, Lassana; Sy, Ngayo; Jawara, Musa; Faye, Ousmane; Kéita, Moussa; Cissé, Moussa; Sogoba, Nafomon; Poudiougou, Belco; Diawara, Sory; Sangaré, Lansana; Coulibaly, Tinzana; Seck, Ibrahima; Abubakar, Ismaela; Gomis, Jules; Mather, Frances J.; Sissako, Aliou; Diarra, Ayouba; Kandeh, Balla; Whalen, Christopher; Moyer, Brian; Nnedu, Obinna; Thiero, Oumar; Bei, Amy K.; Daniels, Rachel; Miura, Kazutoyo; Long, Carole A.; Fairhurst, Rick M.; Duraisingh, Manoj; Muskavitch, Marc A.T.; D’Alessandro, Umberto; Conway, David J.; Volkman, Sarah K.; Valim, Clarissa; Wirth, Dyann F.; Krogstad, Donald J.

2011-01-01

With the paradigm shift from the reduction of morbidity and mortality to the interruption of transmission, the focus of malaria control broadens from symptomatic infections in children ≤ 5 years of age to include asymptomatic infections in older children and adults. In addition, as control efforts intensify and the number of interventions increases, there will be decreases in prevalence, incidence and transmission with additional decreases in morbidity and mortality. Expected secondary consequences of these changes include upward shifts in the peak ages for infection (parasitemia) and disease, increases in the ages for acquisition of antiparasite humoral and cellular immune responses and increases in false-negative blood smears and rapid diagnostic tests. Strategies to monitor these changes must include: 1] studies of the entire population (that are not restricted to children ≤ 5 or ≤ 10 years of age), 2] study sites in both cities and rural areas (because of increasing urbanization across sub-Saharan Africa) and 3] innovative strategies for surveillance as the prevalence of infection decreases and the frequency of false-negative smears and rapid diagnostic tests increases. PMID:22142790

Data-Intensive Science meets Inquiry-Driven Pedagogy: Interactive Big Data Exploration, Threshold Concepts, and Liminality

NASA Technical Reports Server (NTRS)

Ramachandran, Rahul; Word, Andrea; Nair, Udasysankar

2014-01-01

Threshold concepts in any discipline are the core concepts an individual must understand in order to master a discipline. By their very nature, these concepts are troublesome, irreversible, integrative, bounded, discursive, and reconstitutive. Although grasping threshold concepts can be extremely challenging for each learner as s/he moves through stages of cognitive development relative to a given discipline, the learner's grasp of these concepts determines the extent to which s/he is prepared to work competently and creatively within the field itself. The movement of individuals from a state of ignorance of these core concepts to one of mastery occurs not along a linear path but in iterative cycles of knowledge creation and adjustment in liminal spaces - conceptual spaces through which learners move from the vaguest awareness of concepts to mastery, accompanied by understanding of their relevance, connectivity, and usefulness relative to questions and constructs in a given discipline. For example, challenges in the teaching and learning of atmospheric science can be traced to threshold concepts in fluid dynamics. In particular, Dynamic Meteorology is one of the most challenging courses for graduate students and undergraduates majoring in Atmospheric Science. Dynamic Meteorology introduces threshold concepts - those that prove troublesome for the majority of students but that are essential, associated with fundamental relationships between forces and motion in the atmosphere and requiring the application of basic classical statics, dynamics, and thermodynamic principles to the three dimensionally varying atmospheric structure. With the explosive growth of data available in atmospheric science, driven largely by satellite Earth observations and high-resolution numerical simulations, paradigms such as that of dataintensive science have emerged. These paradigm shifts are based on the growing realization that current infrastructure, tools and processes will not allow us to analyze and fully utilize the complex and voluminous data that is being gathered. In this emerging paradigm, the scientific discovery process is driven by knowledge extracted from large volumes of data. In this presentation, we contend that this paradigm naturally lends to inquiry-driven pedagogy where knowledge is discovered through inductive engagement with large volumes of data rather than reached through traditional, deductive, hypothesis-driven analyses. In particular, data-intensive techniques married with an inductive methodology allow for exploration on a scale that is not possible in the traditional classroom with its typical problem sets and static, limited data samples. In addition, we identify existing gaps and possible solutions for addressing the infrastructure and tools as well as a pedagogical framework through which to implement this inductive approach.

Paradigms in epidemiology textbooks: in the footsteps of Thomas Kuhn.

PubMed Central

Bhopal, R

1999-01-01

This article attempts to contribute to the debate on the future of epidemiology by combining Thomas Kuhn's ideas on scientific paradigms with the author's observations on some epidemiology textbooks. The author's interpretations were based on his readings of Kuhn's The Structure of Scientific Revolutions, epidemiology textbooks, and papers on the future of epidemiology. Thomas Kuhn's view is that sciences mostly work with a single paradigm driven by exemplars of successful work, and that proposals for paradigm change are resisted. Sciences that are maturing or changing do not have a dominant paradigm. Epidemiology textbooks showed diversity in their concepts, content, and approach. Most exemplars related to etiologic research rather than public health practice. One key focus of the recent controversy regarding the role of epidemiology has been the increasing inability of epidemiology to solve socially based public health problems. Kuhn's views help explain the polarization of views expressed. Kuhn's philosophy of science offers insights into controversies such as whether a paradigm shift is needed or imminent and the gap between epidemiology and public health practice. Interaction between science philosophers, epidemiologists, and public health practitioners may be valuable. PMID:10432899

Paradigms in epidemiology textbooks: in the footsteps of Thomas Kuhn.

PubMed

Bhopal, R

1999-08-01

This article attempts to contribute to the debate on the future of epidemiology by combining Thomas Kuhn's ideas on scientific paradigms with the author's observations on some epidemiology textbooks. The author's interpretations were based on his readings of Kuhn's The Structure of Scientific Revolutions, epidemiology textbooks, and papers on the future of epidemiology. Thomas Kuhn's view is that sciences mostly work with a single paradigm driven by exemplars of successful work, and that proposals for paradigm change are resisted. Sciences that are maturing or changing do not have a dominant paradigm. Epidemiology textbooks showed diversity in their concepts, content, and approach. Most exemplars related to etiologic research rather than public health practice. One key focus of the recent controversy regarding the role of epidemiology has been the increasing inability of epidemiology to solve socially based public health problems. Kuhn's views help explain the polarization of views expressed. Kuhn's philosophy of science offers insights into controversies such as whether a paradigm shift is needed or imminent and the gap between epidemiology and public health practice. Interaction between science philosophers, epidemiologists, and public health practitioners may be valuable.

Engaging the YouTube Google-Eyed Generation: Strategies for Using Web 2.0 in Teaching and Learning

ERIC Educational Resources Information Center

Duffy, Peter

2008-01-01

YouTube, Podcasting, Blogs, Wikis and RSS are buzz words currently associated with the term Web 2.0 and represent a shifting pedagogical paradigm for the use of a new set of tools within education. The implication here is a possible shift from the basic archetypical vehicles used for (e)learning today (lecture notes, printed material, PowerPoint,…

Artificial Intelligence and brain.

PubMed

Shapshak, Paul

2018-01-01

From the start, Kurt Godel observed that computer and brain paradigms were considered on a par by researchers and that researchers had misunderstood his theorems. He hailed with displeasure that the brain transcends computers. In this brief article, we point out that Artificial Intelligence (AI) comprises multitudes of human-made methodologies, systems, and languages, and implemented with computer technology. These advances enhance development in the electron and quantum realms. In the biological realm, animal neurons function, also utilizing electron flow, and are products of evolution. Mirror neurons are an important paradigm in neuroscience research. Moreover, the paradigm shift proposed here - 'hall of mirror neurons' - is a potentially further productive research tactic. These concepts further expand AI and brain research.

Synergetics in Science and Education

ERIC Educational Resources Information Center

Steklova, I.

2004-01-01

The natural crisis in contemporary culture, conditioned by the emergence of a new cultural paradigm, makes it essential to look for methodological and theoretical foundations of a possible new scientific paradigm, one closely linked to issues in education. In this article, the author presents basic conditions for the self-organization and…

Emerging Paradigms for Applied Drama and Theatre Practice in African Contexts

ERIC Educational Resources Information Center

Chinyowa, Kennedy C.

2009-01-01

The prevailing tendency in applied drama and theatre research and practice in African contexts has been for both critics and practitioners to apply the Freirian educational paradigm of "codification" and "decodification" in the interpretation of their work. Guarav Desai asserts that most of the theoretical premises of applied…

Victims of Domestic Violence and Front-Line Workers: A Helping Paradigm

ERIC Educational Resources Information Center

Peters, Scott W.; Trepal, Heather C.; de Vries, Sabina M.; Day, Sally W.; Leeth, Christopher

2009-01-01

Victims of domestic violence present a challenge to law enforcement and emergency room personnel. The authors propose a helping approach to assist these professionals. This paradigm is composed of: active and empathetic listening, acceptance without judgment, identifying victims' strengths, honoring victims as experts, and the process of leaving…

An adaptive paradigm for human space settlement

NASA Astrophysics Data System (ADS)

Smith, Cameron M.

2016-02-01

Because permanent space settlement will be multigenerational it will have to be viable on ecological timescales so far unfamiliar to those planning space exploration. Long-term viability will require evolutionary and adaptive planning. Adaptations in the natural world provide many lessons for such planning, but implementing these lessons will require a new, evolutionary paradigm for envisioning and carrying out Earth-independent space settlement. I describe some of these adaptive lessons and propose some cognitive shifts required to implement them in a genuinely evolutionary approach to human space settlement.

Do You Want Your Students to Be Job-Ready with 21st Century Skills? Change Pedagogies: A Pedagogical Paradigm Shift from Vygotskyian Social Constructivism to Critical Thinking, Problem Solving and Siemens' Digital Connectivism

ERIC Educational Resources Information Center

Kivunja, Charles

2014-01-01

As Michael Fullan (2001) so cogently asserts, the moral purpose of education is to equip students with the skills that will enable them to be productive citizens when they finish school. Whereas pre-21st century learning paradigms catered reasonably well for the pursuit of this moral purpose in turning out school leavers with specialized skills…

Advancing Treatment of Pituitary Adenomas through Targeted Molecular Therapies: The Acromegaly and Cushing Disease Paradigms.

PubMed

Mooney, Michael A; Simon, Elias D; Little, Andrew S

2016-01-01

The current treatment of pituitary adenomas requires a balance of conservative management, surgical resection, and in select tumor types, molecular therapy. Acromegaly treatment is an evolving field where our understanding of molecular targets and drug therapies has improved treatment options for patients with excess growth hormone levels. We highlight the use of molecular therapies in this disease process and advances in this field, which may represent a paradigm shift for the future of pituitary adenoma treatment.

Paradigm shift: Can TQM save DOD's procurement process?

NASA Astrophysics Data System (ADS)

Romeo, Ross V.

1992-11-01

The Department of Defense's (DOD) ambitious introduction of total quality management (TQM) will fail, unless they change their paradigm and reengineer how they do business. TQM implementation in the defense department and possibilities for reengineering DOD's management structure were investigated. This paper uses a case study to investigate DOD's procurement efficiency and effectiveness with information technology. The findings show DOD is faced with its greatest challenge since WWII in meeting the rapidly evolving environment of the 1990s and the 21st century.

[Four axiological considerations in social epidemiology for the monitoring of health inequality].

PubMed

Mújica, Oscar J

2015-12-01

As the conceptual components of the most important contemporary public health agendas at the global and regional levels are brought into alignment and as it becomes more clearly understood that equity is a constitutive principle of these agendas, there is also a growing awareness of the strategic value of monitoring social inequalities in health. This is the health intelligence tool par excellence, not only for objectively assessing progress towards achieving health equity, but also for reporting action on the social determinants of health, progress towards the attainment of health for all, and the success of intersectoral efforts that take a "health in all policies" approach. These transformations are taking place in the context of an increasingly evident paradigm shift in public health. This essay presents four axiological considerations inherent to-and essential for -conceptualizing and implementing ways to measure and monitor health inequalities: ecoepidemiology as an emerging field in contemporary public health; the determinants of health as the causal model and core of the new paradigm; the relationship between the social hierarchy and health to understand the health gradient; and the practical need for a socioeconomic classification system that captures the social dimension in the determinants of health. The essay argues that these four axiological considerations lend epidemiologic coherence and rationality to the process of measuring and monitoring health inequalities and, by extension, to the development of pro-equity health policy proposals.

A review on the state-of-the-art privacy-preserving approaches in the e-health clouds.

PubMed

Abbas, Assad; Khan, Samee U

2014-07-01

Cloud computing is emerging as a new computing paradigm in the healthcare sector besides other business domains. Large numbers of health organizations have started shifting the electronic health information to the cloud environment. Introducing the cloud services in the health sector not only facilitates the exchange of electronic medical records among the hospitals and clinics, but also enables the cloud to act as a medical record storage center. Moreover, shifting to the cloud environment relieves the healthcare organizations of the tedious tasks of infrastructure management and also minimizes development and maintenance costs. Nonetheless, storing the patient health data in the third-party servers also entails serious threats to data privacy. Because of probable disclosure of medical records stored and exchanged in the cloud, the patients' privacy concerns should essentially be considered when designing the security and privacy mechanisms. Various approaches have been used to preserve the privacy of the health information in the cloud environment. This survey aims to encompass the state-of-the-art privacy-preserving approaches employed in the e-Health clouds. Moreover, the privacy-preserving approaches are classified into cryptographic and noncryptographic approaches and taxonomy of the approaches is also presented. Furthermore, the strengths and weaknesses of the presented approaches are reported and some open issues are highlighted.

Prosocial Behavior and Depression: a Case for Developmental Gender Differences.

PubMed

Alarcón, Gabriela; Forbes, Erika E

2017-06-01

Prosocial behavior and depression are related constructs that both increase during adolescence and display gender-specific effects. The current review surveys literature examining the association between depressive symptoms and prosociality, measured with behavioral economic paradigms, across development and proposes a theoretical model explaining a mechanism through which adolescent girls have higher risk for depression than boys. Relative to healthy controls, prosocial behavior is reduced in adults with major depressive disorder (MDD) but may be increased in adolescents with MDD. The relationship between non-clinical levels of depressive symptoms and prosocial behavior remains to be studied experimentally; however, self-reported prosocial behavior is negatively associated with depressive symptoms in non-clinical adolescents, which may suggest a shift in the relation of prosocial behavior and depressive symptoms across the non-clinical (i.e., negative) to clinical range (i.e., positive). The effect of gender on these developmental and clinical status shifts has not been studied but could have important implications for understanding the emergence of higher rates of depression in girls than boys during adolescence. We propose that girls are at heightened risk for depression due to higher social-evaluative concern and other-oriented prosocial motivation that emphasize the needs of others over the self, leading to more altruistic prosocial behavior (despite personal cost) and a higher burden that enables depressive symptoms.

Prep-ME Software Implementation and Enhancement

DOT National Transportation Integrated Search

2017-09-01

Highway agencies across the United States are moving from empirical design procedures towards the mechanistic-empirical (ME) based pavement design. Even though the Pavement ME Design presents a new paradigm shift with several dramatic improvements, i...

Evolutionary genomics: transdomain gene transfers.

PubMed

Bordenstein, Seth R

2007-11-06

Biologists have until now conceded that bacterial gene transfer to multicellular animals is relatively uncommon in Nature. A new study showing promiscuous insertions of bacterial endosymbiont genes into invertebrate genomes ushers in a shift in this paradigm.

Effect of working consecutive night shifts on sleep time, prior wakefulness, perceived levels of fatigue and performance on a psychometric test in emergency registrars.

PubMed

Haire, Julia Christine Lydia; Ferguson, Sally Anne; Tilleard, James D; Negus, Paul; Dorrian, Jillian; Thomas, Matthew Jw

2012-06-01

To evaluate the effect of working consecutive night shifts on sleep time, prior wakefulness, perceived levels of fatigue and psychomotor performance in a group of Australian emergency registrars. A prospective observational study with a repeated within-subjects component was conducted. Sleep time was determined using sleep diaries and activity monitors. Subjective fatigue levels and reciprocal reaction times were evaluated before and after day and night shifts. A total of 11 registrars participated in the study with 120 shifts analysed. Sleep time was found to be similar during consecutive night and day shifts. The mean number of hours spent awake before the end of a night shift was 14.33. Subjective fatigue scores were worst at the end of a night shift. There was no difference in reciprocal reaction time between the end of night shift and the start of day shift. Registrars sleep a similar amount of time surrounding night and day shifts. Despite reporting the highest levels of fatigue at the end of a night shift, there is no significant difference in reaction times at the end of night shift compared with the beginning of day shift. This correlates with the finding that at the end of night shift the registrars have been awake for less than 16 h, which is the point at which psychomotor performance is expected to decline. © 2012 The Authors. EMA © 2012 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

Principles for designing randomized preventive trials in mental health: an emerging developmental epidemiology paradigm.

PubMed

Brown, C H; Liao, J

1999-10-01

An emerging population-based paradigm is now being used to guide the design of preventive trials used to test developmental models. We discuss elements of the designs of several ongoing randomized preventive trials involving reduction of risk for children of divorce, for children who exhibit behavioral or learning problems, and for children whose parents are being treated for depression. To test developmental models using this paradigm, we introduce three classes of design issues: design for prerandomization, design for intervention, and design for postintervention. For each of these areas, we present quantitative results from power calculations. Both scientific and cost implications of these power calculations are discussed in terms of variation among subjects on preintervention measures, unit of intervention, assignment, balancing, number of pretest and posttest measures, and the examination of moderation effects.

Intelligent holographic databases

NASA Astrophysics Data System (ADS)

Barbastathis, George

Memory is a key component of intelligence. In the human brain, physical structure and functionality jointly provide diverse memory modalities at multiple time scales. How could we engineer artificial memories with similar faculties? In this thesis, we attack both hardware and algorithmic aspects of this problem. A good part is devoted to holographic memory architectures, because they meet high capacity and parallelism requirements. We develop and fully characterize shift multiplexing, a novel storage method that simplifies disk head design for holographic disks. We develop and optimize the design of compact refreshable holographic random access memories, showing several ways that 1 Tbit can be stored holographically in volume less than 1 m3, with surface density more than 20 times higher than conventional silicon DRAM integrated circuits. To address the issue of photorefractive volatility, we further develop the two-lambda (dual wavelength) method for shift multiplexing, and combine electrical fixing with angle multiplexing to demonstrate 1,000 multiplexed fixed holograms. Finally, we propose a noise model and an information theoretic metric to optimize the imaging system of a holographic memory, in terms of storage density and error rate. Motivated by the problem of interfacing sensors and memories to a complex system with limited computational resources, we construct a computer game of Desert Survival, built as a high-dimensional non-stationary virtual environment in a competitive setting. The efficacy of episodic learning, implemented as a reinforced Nearest Neighbor scheme, and the probability of winning against a control opponent improve significantly by concentrating the algorithmic effort to the virtual desert neighborhood that emerges as most significant at any time. The generalized computational model combines the autonomous neural network and von Neumann paradigms through a compact, dynamic central representation, which contains the most salient features of the sensory inputs, fused with relevant recollections, reminiscent of the hypothesized cognitive function of awareness. The Declarative Memory is searched both by content and address, suggesting a holographic implementation. The proposed computer architecture may lead to a novel paradigm that solves 'hard' cognitive problems at low cost.

Novel actions of tissue-type plasminogen activator in chronic kidney disease: a paradigm shift

PubMed Central

Hu, Kebin; Mars, Wendy M.; Liu, Youhua

2009-01-01

Tissue-type plasminogen activator (tPA) is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a crucial role in regulating blood fibrinolysis, in maintaining the homeostasis of extracellular matrix (ECM) and in modulating the post-translational activation of growth factors. However, emerging evidence indicates that tPA may also function as a cytokine that transmits its signal across the cell membrane, initiates a diverse array of intracellular signaling, and dictates gene expression in the nuclei. Structurally, tPA is a kringle-containing protein that shares significant similarity to other classic cytokines such as hepatocyte growth factor (HGF) and macrophage-stimulating protein (MSP). Although there is no dedicated receptor, tPA binds to the cell membrane low density lipoprotein (LDL) receptor-related protein-1 (LRP-1), triggers LRP-1 tyrosine phosphorylation, and activates various intracellular signaling. As a cytokine, tPA plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. It induces matrix matelloproteinase-9 (MMP-9) gene expression in renal interstitial fibroblasts, which causes the destruction of the tubular basement membrane (TBM), thereby facilitating tubular epithelial to mesenchymal transition (EMT). tPA also potentiates myofibroblast activation from quiescent interstitial fibroblasts through LRP-1-mediated recruitment of β1 integrin signaling. Furthermore, tPA acts as a survival factor that protects renal interstitial fibroblasts/myofibroblasts from apoptosis, thereby resulting in an expansion of myofibroblast populations in diseased kidney. Together, a growing body of evidence has implicated tPA as a fibrogenic cytokine that promotes the progression of kidney diseases. These new findings have radically changed our conception of tPA in renal fibrogenesis and represent a paradigm shift towards uncovering its cytokine function. A better understanding of renal tPA biology will ultimately translate into more rational therapeutic remedies for patients with chronic kidney fibrosis. PMID:18508579

Transportation planning for electric vehicles and associated infrastructure.

DOT National Transportation Integrated Search

2017-05-01

Planning is the key to successful adoption and deployment of any new technology, and : it is particularly important when that advancement involves a paradigm shift such as : electrified transportation. At its core, electric transportation is largely ...

A new insight into root responses to external cues: Paradigm shift in nutrient sensing

PubMed Central

Bhardwaj, Deepak; Medici, Anna; Gojon, Alain; Lacombe, Benoît; Tuteja, Narendra

2015-01-01

Higher plants are sessile and their growth relies on nutrients present in the soil. The acquisition of nutrients is challenging for plants. Phosphate and nitrate sensing and signaling cascades play significant role during adverse conditions of nutrient unavailability. Therefore, it is important to dissect the mechanism by which plant roots acquire nutrients from the soil. Root system architecture (RSA) exhibits extensive developmental flexibility and changes during nutrient stress conditions. Growth of root system in response to external concentration of nutrients is a joint operation of sensor or receptor proteins along with several other cytoplasmic accessory proteins. After nutrient sensing, sensor proteins start the cellular relay involving transcription factors, kinases, ubiquitin ligases and miRNA. The complexity of nutrient sensing is still nebulous and many new players need to be better studied. This review presents a survey of recent paradigm shift in the advancements in nutrient sensing in relation to plant roots. PMID:26146897

The paradox of progress: translating Evan Stark's Coercive Control into legal doctrine for abused women.

PubMed

Hanna, Cheryl

2009-12-01

This article examines Evan Stark's model of coercive control and what this paradigm shift might mean for the law. Coercive control can help redefine both criminal offenses involving domestic violence and defenses available to women who kill their abusers. This redefinition would shift the law away from incident-based violence and toward a more comprehensive and accurate paradigm that accounts for the deprivation of a woman's autonomy within the context of an abusive relationship. Such a change would likely provide more effective state intervention into what were once considered private relationships. Yet, this approach may also have some unintended consequences, including refocusing the law on a victim's mental state and complicity in her own abuse rather than on the harm caused by abusive men. Thus, although the law should more fully account for coercive control, lawyers must be cautiously optimistic in implementing Stark's proposed reforms.

Shifting the paradigm in Oregon from teen pregnancy prevention to youth sexual health.

PubMed

Nystrom, Robert J; Duke, Jessica E A; Victor, Brad

2013-01-01

Oregon's work on teen pregnancy prevention during the previous 20 years has shifted from a risk-focused paradigm to a youth development model that places young people at the center of their sexual health and well-being. During 2005, the Oregon Governor's Office requested that an ad hoc committee of state agency and private partners develop recommendations for the next phase of teen pregnancy prevention. As a result of that collaborative effort, engagement of young people, and community input, the Oregon Youth Sexual Health Plan was released in 2009. The plan focuses on development of young people and embraces sexuality as a natural part of adolescent development. The plan's five goals and eight objectives guide the work of state agencies and partners addressing youth sexual health. Oregon's development of a statewide plan can serve as a framework for other states and entities to address all aspects of youth sexual health.

Paradigm shift in consciousness research: the child's self-awareness and abnormalities in autism, ADHD and schizophrenia.

PubMed

Lou, Hans C

2012-02-01

Self-awareness is a pivotal component of any conscious experience and conscious self-regulation of behaviour. A paralimbic network is active, specific and causal in self-awareness. Its regions interact by gamma synchrony. Gamma synchrony develops throughout infancy, childhood and adolescence into adulthood and is regulated by dopamine and other neurotransmitters via GABA interneurons. Major derailments of this network and self-awareness occur in developmental disorders of conscious self-regulation like autism, attention deficit hyperactivity disorder (ADHD) and schizophrenia. Recent research on conscious experience is no longer limited to the study of neural 'correlations' but is increasingly lending itself to the study of causality. This paradigm shift opens new perspectives for understanding the neural mechanisms of the developing self and the causal effects of their disturbance in developmental disorders. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

Shifting the Paradigm in Oregon from Teen Pregnancy Prevention to Youth Sexual Health

PubMed Central

Nystrom, Robert J.; Duke, Jessica E.A.; Victor, Brad

2013-01-01

Oregon's work on teen pregnancy prevention during the previous 20 years has shifted from a risk-focused paradigm to a youth development model that places young people at the center of their sexual health and well-being. During 2005, the Oregon Governor's Office requested that an ad hoc committee of state agency and private partners develop recommendations for the next phase of teen pregnancy prevention. As a result of that collaborative effort, engagement of young people, and community input, the Oregon Youth Sexual Health Plan was released in 2009. The plan focuses on development of young people and embraces sexuality as a natural part of adolescent development. The plan's five goals and eight objectives guide the work of state agencies and partners addressing youth sexual health. Oregon's development of a statewide plan can serve as a framework for other states and entities to address all aspects of youth sexual health. PMID:23450889

The aerodynamics of the sinonasal interface: the nose takes wing-a paradigm shift for our time.

PubMed

Gungor, Anil A

2013-04-01

Ventilation of and gas exchange between the nose and the paranasal sinuses are believed to occur by convection and diffusion based on experiments that neglect the effects of physiological respiration and aerodynamic forces at the sinonasal interface (SNI). Based on these experiments, the exchange of gas is presumed to be slow, and principally dependent on gas concentration and diameter, number, and location of ostia. In 12 healthy adult volunteers, real-time sinus nitric oxide measurements were obtained with catheters placed through natural ostia during respiratory maneuvers. The nose is a masterful collection of aerodynamic foils and channels designed to accomplish powered sinonasal gas exchange and ventilation within a few seconds during each inspiration. The new perspective on the functional anatomy of the SNI demands a paradigm shift that is followed by physiological, medical, and surgical implications and a radical change in our perception and understanding. © 2013 ARS-AAOA, LLC.

Consequences of "going digital" for pathology professionals - entering the cloud.

PubMed

Laurinavicius, Arvydas; Raslavicus, Paul

2012-01-01

New opportunities and the adoption of digital technologies will transform the way pathology professionals and services work. Many areas of our daily life as well as medical professions have experienced this change already which has resulted in a paradigm shift in many activities. Pathology is an image-based discipline, therefore, arrival of digital imaging into this domain promises major shift in our work and required mentality. Recognizing the physical and digital duality of the pathology workflow, we can prepare for the imminent increase of the digital component, synergize and enjoy its benefits. Development of a new generation of laboratory information systems along with seamless integration of digital imaging, decision-support, and knowledge databases will enable pathologists to work in a distributed environment. The paradigm of "cloud pathology" is proposed as an ultimate vision of digital pathology workstations plugged into the integrated multidisciplinary patient care systems.

A Legislative Reform for the Food Safety System of China: A Regulatory Paradigm Shift and Collaborative Governance.

PubMed

Han, Yonghong

2015-01-01

After describing the historical development of China's food safety system from the perspectives of legislation and administration, this article discusses progress in its food law (The Draft Amendments to Food Safety Law). As a further legislative reform for China's food safety system, the Draft Amendments to the Food Safety Law contain innovative institutional designs and manifest a regulatory paradigm shift from government-centered governance to collaborative governance. However, the Draft Amendments face challenges in their implementation. This article argues that developing collaborative governance for food safety in China can be a solution to these challenges. Based on theoretical and empirical studies of collaborative governance, this article proposes that the institutional design of collaborative governance should focus on providing obligations for administrative agencies in the process of food safety rule-making and standard-setting, increasing the independence of nongovernmental organizations, and building two-way electronic platforms for public participation.

MRI-guided robotics at the U of Houston: evolving methodologies for interventions and surgeries.

PubMed

Tsekos, Nikolaos V

2009-01-01

Currently, we witness the rapid evolution of minimally invasive surgeries (MIS) and image guided interventions (IGI) for offering improved patient management and cost effectiveness. It is well recognized that sustaining and expand this paradigm shift would require new computational methodology that integrates sensing with multimodal imaging, actively controlled robotic manipulators, the patient and the operator. Such approach would include (1) assessing in real-time tissue deformation secondary to the procedure and physiologic motion, (2) monitoring the tool(s) in 3D, and (3) on-the-fly update information about the pathophysiology of the targeted tissue. With those capabilities, real time image guidance may facilitate a paradigm shift and methodological leap from "keyhole" visualization (i.e. endoscopy or laparoscopy) to one that uses a volumetric and informational rich perception of the Area of Operation (AoO). This capability may eventually enable a wider range and level of complexity IGI and MIS.

From Axenic to Mixed Cultures: Technological Advances Accelerating a Paradigm Shift in Microbiology.

PubMed

Nai, Corrado; Meyer, Vera

2018-06-01

Since the onset of microbiology in the late 19th century, scientists have been growing microorganisms almost exclusively as pure cultures, resulting in a limited and biased view of the microbial world. Only a paradigm shift in cultivation techniques - from axenic to mixed cultures - can allow a full comprehension of the (chemical) communication of microorganisms, with profound consequences for natural product discovery, microbial ecology, symbiosis, and pathogenesis, to name a few areas. Three main technical advances during the last decade are fueling the realization of this revolution in microbiology: microfluidics, next-generation 3D-bioprinting, and single-cell metabolomics. These technological advances can be implemented for large-scale, systematic cocultivation studies involving three or more microorganisms. In this review, we present recent trends in microbiology tools and discuss how these can be employed to decode the chemical language that microorganisms use to communicate. Copyright © 2017 Elsevier Ltd. All rights reserved.

Systematic Review and Meta-analysis of the Effects of Caffeine in Fatigued Shift Workers: Implications for Emergency Medical Services Personnel

DOT National Transportation Integrated Search

2018-01-11

Background: Emergency Medical Services (EMS) workers may experience fatigue as a consequence of shift work. We reviewed the literature to determine the impact of caffeine as a countermeasure to fatigue in EMS personnel and related shift workers. Meth...

Nanotoxicology and nanomedicine: making development decisions in an evolving governance environment

NASA Astrophysics Data System (ADS)

Rycroft, Taylor; Trump, Benjamin; Poinsatte-Jones, Kelsey; Linkov, Igor

2018-02-01

The fields of nanomedicine, risk analysis, and decision science have evolved considerably in the past decade, providing developers of nano-enabled therapies and diagnostic tools with more complete information than ever before and shifting a fundamental requisite of the nanomedical community from the need for more information about nanomaterials to the need for a streamlined method of integrating the abundance of nano-specific information into higher-certainty product design decisions. The crucial question facing nanomedicine developers that must select the optimal nanotechnology in a given situation has shifted from "how do we estimate nanomaterial risk in the absence of good risk data?" to "how can we derive a holistic characterization of the risks and benefits that a given nanomaterial may pose within a specific nanomedical application?" Many decision support frameworks have been proposed to assist with this inquiry; however, those based in multicriteria decision analysis have proven to be most adaptive in the rapidly evolving field of nanomedicine—from the early stages of the field when conditions of significant uncertainty and incomplete information dominated, to today when nanotoxicology and nano-environmental health and safety information is abundant but foundational paradigms such as chemical risk assessment, risk governance, life cycle assessment, safety-by-design, and stakeholder engagement are undergoing substantial reformation in an effort to address the needs of emerging technologies. In this paper, we reflect upon 10 years of developments in nanomedical engineering and demonstrate how the rich knowledgebase of nano-focused toxicological and risk assessment information developed over the last decade enhances the capability of multicriteria decision analysis approaches and underscores the need to continue the transition from traditional risk assessment towards risk-based decision-making and alternatives-based governance for emerging technologies.

Integrating genomics into clinical oncology: ethical and social challenges from proponents of personalized medicine.

PubMed

McGowan, Michelle L; Settersten, Richard A; Juengst, Eric T; Fishman, Jennifer R

2014-02-01

The use of molecular tools to individualize health care, predict appropriate therapies, and prevent adverse health outcomes has gained significant traction in the field of oncology under the banner of "personalized medicine" (PM). Enthusiasm for PM in oncology has been fueled by success stories of targeted treatments for a variety of cancers based on their molecular profiles. Though these are clear indications of optimism for PM, little is known about the ethical and social implications of personalized approaches in clinical oncology. The objective of this study is to assess how a range of stakeholders engaged in promoting, monitoring, and providing PM understand the challenges of integrating genomic testing and targeted therapies into clinical oncology. The study involved the analysis of in-depth interviews with 117 stakeholders whose experiences and perspectives on PM span a wide variety of institutional and professional settings. Despite their considerable enthusiasm for this shift, promoters, monitors, and providers of PM identified 4 domains that provoke heightened ethical and social concerns: (1) informed consent for cancer genomic testing, (2) privacy, confidentiality, and disclosure of genomic test results, (3) access to genomic testing and targeted therapies in oncology, and (4) the costs of scaling up pharmacogenomic testing and targeted cancer therapies. These specific concerns are not unique to oncology, or even genomics. However, those most invested in the success of PM view oncologists' responses to these challenges as precedent setting because oncology is farther along the path of clinical integration of genomic technologies than other fields of medicine. This study illustrates that the rapid emergence of PM approaches in clinical oncology provides a crucial lens for identifying and managing potential frictions and pitfalls that emerge as health care paradigms shift in these directions. © 2014 Published by Elsevier Inc.

Smart grids: A paradigm shift on energy generation and distribution with the emergence of a new energy management business model

NASA Astrophysics Data System (ADS)

Cardenas, Jesus Alvaro

An energy and environmental crisis will emerge throughout the world if we continue with our current practices of generation and distribution of electricity. A possible solution to this problem is based on the Smart grid concept, which is heavily influenced by Information and Communication Technology (ICT). Although the electricity industry is mostly regulated, there are global models used as roadmaps for Smart Grids' implementation focusing on technologies and the basic generation-distribution-transmission model. This project aims to further enhance a business model for a future global deployment. It takes into consideration the many factors interacting in this energy provision process, based on the diffusion of technologies and literature surveys on the available documents in the Internet as well as peer-reviewed publications. Tariffs and regulations, distributed energy generation, integration of service providers, consumers becoming producers, self-healing devices, and many other elements are shifting this industry into a major change towards liberalization and deregulation of this sector, which has been heavily protected by the government due to the importance of electricity for consumers. We propose an Energy Management Business Model composed by four basic elements: Supply Chain, Information and Communication Technology (ICT), Stakeholders Response, and the resulting Green Efficient Energy (GEE). We support the developed model based on the literature survey, we support it with the diffusion analysis of these elements, and support the overall model with two surveys: one for peers and professionals, and other for experts in the field, based on the Smart Grid Carnegie Melon Maturity Model (CMU SEI SGMM). The contribution of this model is a simple path to follow for entities that want to achieve environmental friendly energy with the involvement of technology and all stakeholders.

Squaring the circle. Social and environmental implications of pre-pottery neolithic building technology at Tell Qarassa (South Syria).

PubMed

Balbo, Andrea L; Iriarte, Eneko; Arranz, Amaia; Zapata, Lydia; Lancelotti, Carla; Madella, Marco; Teira, Luis; Jiménez, Miguel; Braemer, Frank; Ibáñez, Juan José

2012-01-01

We present the results of the microstratigraphic, phytolith and wood charcoal study of the remains of a 10.5 ka roof. The roof is part of a building excavated at Tell Qarassa (South Syria), assigned to the Pre-Pottery Neolithic B period (PPNB). The Pre-Pottery Neolithic (PPN) period in the Levant coincides with the emergence of farming. This fundamental change in subsistence strategy implied the shift from mobile to settled aggregated life, and from tents and huts to hard buildings. As settled life spread across the Levant, a generalised transition from round to square buildings occurred, that is a trademark of the PPNB period. The study of these buildings is fundamental for the understanding of the ever-stronger reciprocal socio-ecological relationship humans developed with the local environment since the introduction of sedentism and domestication. Descriptions of buildings in PPN archaeological contexts are usually restricted to the macroscopic observation of wooden elements (posts and beams) and mineral components (daub, plaster and stone elements). Reconstructions of microscopic and organic components are frequently based on ethnographic analogy. The direct study of macroscopic and microscopic, organic and mineral, building components performed at Tell Qarassa provides new insights on building conception, maintenance, use and destruction. These elements reflect new emerging paradigms in the relationship between Neolithic societies and the environment. A square building was possibly covered here with a radial roof, providing a glance into a topologic shift in the conception and understanding of volumes, from round-based to square-based geometries. Macroscopic and microscopic roof components indicate buildings were conceived for year-round residence rather than seasonal mobility. This implied performing maintenance and restoration of partially damaged buildings, as well as their adaptation to seasonal variability.

Squaring the Circle. Social and Environmental Implications of Pre-Pottery Neolithic Building Technology at Tell Qarassa (South Syria)

PubMed Central

Balbo, Andrea L.; Iriarte, Eneko; Arranz, Amaia; Zapata, Lydia; Lancelotti, Carla; Madella, Marco; Teira, Luis; Jiménez, Miguel; Braemer, Frank; Ibáñez, Juan José

2012-01-01

We present the results of the microstratigraphic, phytolith and wood charcoal study of the remains of a 10.5 ka roof. The roof is part of a building excavated at Tell Qarassa (South Syria), assigned to the Pre-Pottery Neolithic B period (PPNB). The Pre-Pottery Neolithic (PPN) period in the Levant coincides with the emergence of farming. This fundamental change in subsistence strategy implied the shift from mobile to settled aggregated life, and from tents and huts to hard buildings. As settled life spread across the Levant, a generalised transition from round to square buildings occurred, that is a trademark of the PPNB period. The study of these buildings is fundamental for the understanding of the ever-stronger reciprocal socio-ecological relationship humans developed with the local environment since the introduction of sedentism and domestication. Descriptions of buildings in PPN archaeological contexts are usually restricted to the macroscopic observation of wooden elements (posts and beams) and mineral components (daub, plaster and stone elements). Reconstructions of microscopic and organic components are frequently based on ethnographic analogy. The direct study of macroscopic and microscopic, organic and mineral, building components performed at Tell Qarassa provides new insights on building conception, maintenance, use and destruction. These elements reflect new emerging paradigms in the relationship between Neolithic societies and the environment. A square building was possibly covered here with a radial roof, providing a glance into a topologic shift in the conception and understanding of volumes, from round-based to square-based geometries. Macroscopic and microscopic roof components indicate buildings were conceived for year-round residence rather than seasonal mobility. This implied performing maintenance and restoration of partially damaged buildings, as well as their adaptation to seasonal variability. PMID:22848723

Executive summary: value-based purchasing and technology assessment in orthopaedics.

PubMed

Ranawat, Anil S; Nunley, Ryan; Bozic, Kevin

2009-10-01

As US healthcare expenditures continue to rise, reform has shifted from spending controls to value-based purchasing. This paradigm shift is a drastic change on how health care is delivered and reimbursed. For the shift to work, policymakers and physicians must restructure the present system by using initiatives such as process reengineering, insurance and payment reforms, physician reeducation, data and quality measurements, and technology assessments. Value, as defined in economic terms, will be a critical concept in modern healthcare reform. We summarize the conclusions of this ABJS Carl T. Brighton Workshop on healthcare reform.

Exploring the promises of intersectionality for advancing women's health research

PubMed Central

2010-01-01

Women's health research strives to make change. It seeks to produce knowledge that promotes action on the variety of factors that affect women's lives and their health. As part of this general movement, important strides have been made to raise awareness of the health effects of sex and gender. The resultant base of knowledge has been used to inform health research, policy, and practice. Increasingly, however, the need to pay better attention to the inequities among women that are caused by racism, colonialism, ethnocentrism, heterosexism, and able-bodism, is confronting feminist health researchers and activists. Researchers are seeking new conceptual frameworks that can transform the design of research to produce knowledge that captures how systems of discrimination or subordination overlap and "articulate" with one another. An emerging paradigm for women's health research is intersectionality. Intersectionality places an explicit focus on differences among groups and seeks to illuminate various interacting social factors that affect human lives, including social locations, health status, and quality of life. This paper will draw on recently emerging intersectionality research in the Canadian women's health context in order to explore the promises and practical challenges of the processes involved in applying an intersectionality paradigm. We begin with a brief overview of why the need for an intersectionality approach has emerged within the context of women's health research and introduce current thinking about how intersectionality can inform and transform health research more broadly. We then highlight novel Canadian research that is grappling with the challenges in addressing issues of difference and diversity. In the analysis of these examples, we focus on a largely uninvestigated aspect of intersectionality research - the challenges involved in the process of initiating and developing such projects and, in particular, the meaning and significance of social locations for researchers and participants who utilize an intersectionality approach. The examples highlighted in the paper represent important shifts in the health field, demonstrating the potential of intersectionality for examining the social context of women's lives, as well as developing methods which elucidate power, create new knowledge, and have the potential to inform appropriate action to bring about positive social change. PMID:20181225

Exploring the promises of intersectionality for advancing women's health research.

PubMed

Hankivsky, Olena; Reid, Colleen; Cormier, Renee; Varcoe, Colleen; Clark, Natalie; Benoit, Cecilia; Brotman, Shari

2010-02-11

Women's health research strives to make change. It seeks to produce knowledge that promotes action on the variety of factors that affect women's lives and their health. As part of this general movement, important strides have been made to raise awareness of the health effects of sex and gender. The resultant base of knowledge has been used to inform health research, policy, and practice. Increasingly, however, the need to pay better attention to the inequities among women that are caused by racism, colonialism, ethnocentrism, heterosexism, and able-bodism, is confronting feminist health researchers and activists. Researchers are seeking new conceptual frameworks that can transform the design of research to produce knowledge that captures how systems of discrimination or subordination overlap and "articulate" with one another. An emerging paradigm for women's health research is intersectionality. Intersectionality places an explicit focus on differences among groups and seeks to illuminate various interacting social factors that affect human lives, including social locations, health status, and quality of life. This paper will draw on recently emerging intersectionality research in the Canadian women's health context in order to explore the promises and practical challenges of the processes involved in applying an intersectionality paradigm. We begin with a brief overview of why the need for an intersectionality approach has emerged within the context of women's health research and introduce current thinking about how intersectionality can inform and transform health research more broadly. We then highlight novel Canadian research that is grappling with the challenges in addressing issues of difference and diversity. In the analysis of these examples, we focus on a largely uninvestigated aspect of intersectionality research - the challenges involved in the process of initiating and developing such projects and, in particular, the meaning and significance of social locations for researchers and participants who utilize an intersectionality approach. The examples highlighted in the paper represent important shifts in the health field, demonstrating the potential of intersectionality for examining the social context of women's lives, as well as developing methods which elucidate power, create new knowledge, and have the potential to inform appropriate action to bring about positive social change.

Emerging and Future Computing Paradigms and Their Impact on the Research, Training, and Design Environments of the Aerospace Workforce

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler)

2003-01-01

The document contains the proceedings of the training workshop on Emerging and Future Computing Paradigms and their impact on the Research, Training and Design Environments of the Aerospace Workforce. The workshop was held at NASA Langley Research Center, Hampton, Virginia, March 18 and 19, 2003. The workshop was jointly sponsored by Old Dominion University and NASA. Workshop attendees came from NASA, other government agencies, industry and universities. The objectives of the workshop were to a) provide broad overviews of the diverse activities related to new computing paradigms, including grid computing, pervasive computing, high-productivity computing, and the IBM-led autonomic computing; and b) identify future directions for research that have high potential for future aerospace workforce environments. The format of the workshop included twenty-one, half-hour overview-type presentations and three exhibits by vendors.

The Legacy of "A Nation at Risk"

ERIC Educational Resources Information Center

Burdick, Jonathan

2012-01-01

Nearly thirty years after the Cold War era commission's report titled "A Nation at Risk: The Imperative for Educational Reform," educators and historians must evaluate its relevance and its contribution to the shifting educational paradigm in the United States.

Environmental toxicology: Interconnections between human health and ecological integrity

EPA Science Inventory

This presentation will discuss what has made a career in environmental toxicology rewarding, environmental and scientific challenges for the 21st century, paradigm shift in regulatory toxicology, adverse outcome framework, interconnections between human health and ecological inte...

INCORPORATING NONCHEMICAL STRESSORS INTO CUMMULATIVE RISK ASSESSMENTS

EPA Science Inventory

The risk assessment paradigm has begun to shift from assessing single chemicals using "reasonable worst case" assumptions for individuals to considering multiple chemicals and community-based models. Inherent in community-based risk assessment is examination of all stressors a...

Convergent Technologies in Distance Learning Delivery.

ERIC Educational Resources Information Center

Wheeler, Steve

1999-01-01

Describes developments in British education in distance learning technologies. Highlights include networking the rural areas; communication, community, and paradigm shifts; digital compression techniques and telematics; Web-based material delivered over the Internet; system flexibility; social support; learning support; videoconferencing; and…

The Learning Alliance: Systems Thinking in Human Resource Development. First Edition. The Jossey-Bass Management Series.

ERIC Educational Resources Information Center

Brinkerhoff, Robert O.; Gill, Stephen J.

This book presents an approach that organizes the principles and processes of an emerging human resource development (HRD) paradigm requiring training to be everyone's business. Chapter 1 describes the paradigm and presents a practical approach for applying it. Chapter 2 draws a picture of highly effective training (HET), focusing particularly on…

Qualitative Research in Educational Communications and Technology: A Brief Introduction to Principles and Procedures

ERIC Educational Resources Information Center

Neuman, Delia

2014-01-01

Over the past 30 years, qualitative research has emerged as a widely accepted alternative to the quantitative paradigm for performing research in educational communications and technology. As the new paradigm has evolved, it has spawned a variety of theoretical perspectives and methodological techniques that have both increased its potential…

Competence-Related Metadata for Educational Resources that Support Lifelong Competence Development Programmes

ERIC Educational Resources Information Center

Sampson, Demetrios G.

2009-01-01

In the context of the emerging paradigm of Lifelong Learning, competence-based learning is gradually attracting the attention of the Technology-Enhanced Learning community, since it appears to meet the 21st Century learning and training expectations of both individuals and organisations. On the other hand, the paradigm of Learning Objects--as a…

Of Pigs and Wolves at the OK Corral--or the Emerging Alternative Paradigm and the Construction of Knowledge.

ERIC Educational Resources Information Center

Huber, Tonya

1996-01-01

Explores the need for recognizing and respecting different learner perspectives in order to better develop culturally responsive pedagogy. It argues for a new constructionist paradigm for teaching within a multicultural setting, which does not emphasize assimilation into the dominant culture, but enhances the learner's potential for creating anew…

Paradigms and Problems: Thomas Kuhn and "Composition Revolutions".

ERIC Educational Resources Information Center

Tallman, John Gary

The arguments for and against Thomas Kuhn's paradigmatic thesis are presented in this paper as a means of discussing the appropriateness of Kuhn's thesis to the emerging composition discipline. Section one of the paper introduces the topic, noting how the term paradigm is used in composition to define a system of widely shared values, beliefs, and…

Towards sustainable traumatic brain injury care systems: healthcare leadership imperatives in Canada.

PubMed

Caro, Denis

2011-01-01

Traumatic brain injuries pose strategic population health challenges in the face of burgeoning clinical demands that continue to tax capital, financial, and social resource capacities. The sustainability of traumatic brain injury care systems depends on paradigmatic shifts in healthcare leadership thinking. In quest for high-performance care and sustained quality of life for traumatic brain injury patients, this article presents a unique paradigm of seven care performance layers and seven health leadership imperatives that together form the paradigm for the systemic sustainability of TBI care systems of the future.

Genomic instability and bystander effects: a paradigm shift in radiation biology?

NASA Technical Reports Server (NTRS)

Morgan, William F.

2002-01-01

A basic paradigm in radiobiology is that, following exposure to ionizing radiation, the deposition of energy in the cell nucleus and the resulting damage to DNA, the principal target, are responsible for the radiation's deleterious biological effects. Findings in two rapidly expanding fields of research--radiation-induced genomic instability and bystander effects--have caused us to reevaluate these central tenets. In this article, the potential influence of induced genomic instability and bystander effects on cellular injury after exposure to low-level radiation will be reviewed.

[Paradigm shift in dentistry for children: from restorative to preventive treatment of caries].

PubMed

van Amerongen, J P; van Palenstein Helderman, W H

2010-03-01

First, the development of dental health care for children in the Netherlands is discussed. Caries prevalence among children has declined sharply. The present situation, however, makes clear that the majority of carious cavities in the temporary dentition remain untreated. This has led to the conclusion that the level of restorative care has to increase. On the basis of new insights in cariology gained in recent decades, the authors of this article argue for abandoning the old paradigm of restorative treatment in favour of prevention in the treatment of caries.

Visual attention shift to printed words during spoken word recognition in Chinese: The role of phonological information.

PubMed

Shen, Wei; Qu, Qingqing; Tong, Xiuhong

2018-05-01

The aim of this study was to investigate the extent to which phonological information mediates the visual attention shift to printed Chinese words in spoken word recognition by using an eye-movement technique with a printed-word paradigm. In this paradigm, participants are visually presented with four printed words on a computer screen, which include a target word, a phonological competitor, and two distractors. Participants are then required to select the target word using a computer mouse, and the eye movements are recorded. In Experiment 1, phonological information was manipulated at the full-phonological overlap; in Experiment 2, phonological information at the partial-phonological overlap was manipulated; and in Experiment 3, the phonological competitors were manipulated to share either fulloverlap or partial-overlap with targets directly. Results of the three experiments showed that the phonological competitor effects were observed at both the full-phonological overlap and partial-phonological overlap conditions. That is, phonological competitors attracted more fixations than distractors, which suggested that phonological information mediates the visual attention shift during spoken word recognition. More importantly, we found that the mediating role of phonological information varies as a function of the phonological similarity between target words and phonological competitors.

Immuno-Oncology-The Translational Runway for Gene Therapy: Gene Therapeutics to Address Multiple Immune Targets.

PubMed

Weß, Ludger; Schnieders, Frank

2017-12-01

Cancer therapy is once again experiencing a paradigm shift. This shift is based on extensive clinical experience demonstrating that cancer cannot be successfully fought by addressing only single targets or pathways. Even the combination of several neo-antigens in cancer vaccines is not sufficient for successful, lasting tumor eradication. The focus has therefore shifted to the immune system's role in cancer and the striking abilities of cancer cells to manipulate and/or deactivate the immune system. Researchers and pharma companies have started to target the processes and cells known to support immune surveillance and the elimination of tumor cells. Immune processes, however, require novel concepts beyond the traditional "single-target-single drug" paradigm and need parallel targeting of diverse cells and mechanisms. This review gives a perspective on the role of gene therapy technologies in the evolving immuno-oncology space and identifies gene therapy as a major driver in the development and regulation of effective cancer immunotherapy. Present challenges and breakthroughs ranging from chimeric antigen receptor T-cell therapy, gene-modified oncolytic viruses, combination cancer vaccines, to RNA therapeutics are spotlighted. Gene therapy is recognized as the most prominent technology enabling effective immuno-oncology strategies.

Effects of shifts in the rate of repetitive stimulation on sustained attention

NASA Technical Reports Server (NTRS)

Krulewitz, J. E.; Warm, J. S.; Wohl, T. H.

1975-01-01

The effects of shifts in the rate of presentation of repetitive neutral events (background event rate) were studied in a visual vigilance task. Four groups of subjects experienced either a high (21 events/min) or a low (6 events/min) event rate for 20 min and then experienced either the same or the alternate event rate for an additional 40 min. The temporal occurrence of critical target signals was identical for all groups, irrespective of event rate. The density of critical signals was 12 signals/20 min. By the end of the session, shifts in event rate were associated with changes in performance which resembled contrast effects found in other experimental situations in which shift paradigms were used. Relative to constant event rate control conditions, a shift from a low to a high event rate depressed the probability of signal detections, while a shift in the opposite direction enhanced the probability of signal detections.

Quantum ergonomics: shifting the paradigm of the systems agenda.

PubMed

Walker, Guy H; Salmon, Paul M; Bedinger, Melissa; Stanton, Neville A

2017-02-01

A paradigm is an accepted world view. If we do not continually question our paradigm then wider trends and movements will overtake the discipline leaving it ill adapted to future challenges. This Special Issue is an opportunity to keep systems thinking at the forefront of ergonomics theory and practice. Systems thinking prompts us to ask whether ergonomics, as a discipline, has been too timid? Too preoccupied with the resolution of immediate problems with industrial-age methods when, approaching fast, are developments which could render these operating assumptions an irrelevance. Practical case studies are presented to show how abstract systems problems can be tackled head-on to deliver highly innovative and cost-effective insights. The strategic direction of the discipline foregrounds high-quality systems problems. These are something the discipline is well able to respond to provided that the appropriate operating paradigms are selected. Practitioner Summary: High-quality systems problems are the future of the discipline. How do we convert obtuse sounding systems concepts into practical interventions? In this paper, the essence of systems thinking is distilled and practical case studies used to demonstrate the benefits of this new paradigm.

Review of evolving trends in blended wing body aircraft design

NASA Astrophysics Data System (ADS)

Okonkwo, Paul; Smith, Howard

2016-04-01

The desire to produce environmentally friendly aircraft that is aerodynamically efficient and capable of conveying large number of passengers over long ranges at reduced direct operating cost led aircraft designers to develop the Blended Wing Body (BWB) aircraft concept. The BWB aircraft represents a paradigm shift in the design of aircraft. The design provides aerodynamics and environmental benefits and is suitable for the integration of advanced systems and concepts like laminar flow technology, jet flaps and distributed propulsion. However, despite these benefits, the BWB is yet to be developed for commercial air transport due to several challenges. This paper reviews emerging trends in BWB aircraft design highlighting design challenges that have hindered the development of a BWB passenger transport aircraft. The study finds that in order to harness the advantages and reduce the deficiencies of a tightly coupled configuration like the BWB, a multidisciplinary design synthesis optimisation should be conducted with good handling and ride quality as objective functions within acceptable direct operating cost and noise bounds.

Guidelines for the Management of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA).

PubMed

Schmidt-Erfurth, Ursula; Garcia-Arumi, Jose; Bandello, Francesco; Berg, Karina; Chakravarthy, Usha; Gerendas, Bianca S; Jonas, Jost; Larsen, Michael; Tadayoni, Ramin; Loewenstein, Anat

2017-01-01

Diabetic retinal disease is envisioned to become the plague of the coming decades with a steep increase of worldwide diabetes incidence followed by a substantial rise in retinal disease. Improvements in diagnostic and therapeutic care have to cope with this dilemma in a clinically and socioeconomically efficient manner. Laser treatment has found a less destructive competitor in pharmacological treatments. As a consequence of recent rigorous clinical trials, laser photocoagulation is no longer recommended for the treatment of diabetic macular edema (DME), and anti-vascular endothelial growth factor therapy has emerged as first-line therapy. Steroids have maintained a role in the management of chronically persistent DME. The paradigm shifts in therapy are accompanied by a substantial break-through in diagnostics. The following guidance for the management of DME has been composed from the best updated knowledge of leading experts in Europe and represents another volume in the series of EURETINA recommendations for the management of retinal disease. © 2017 S. Karger AG, Basel.

Enhanced spin-phonon-electronic coupling in a 5d oxide

DOE PAGES

Calder, Stuart A.; Yamaura, K.; Tsujimoto, Y.; ...

2015-11-26

Enhanced coupling of material properties offers new fundamental insights and routes to multifunctional devices. In this context 5d oxides provide new paradigms of cooperative interactions that drive novel emergent behaviour. This is exemplified in osmates that host metal insulator transitions where magnetic order appears intimately entwined. Here we consider such a material, the 5d perovskite NaOsO 3, and observe a coupling between spin and phonon manifested in a frequency shift of 40 cm 1, the largest measured in any material. The anomalous modes are shown to involve solely Os O interactions and magnetism is revealed as the driving microscopic mechanismmore » for the phonon renormalization. The magnitude of the coupling in NaOsO 3 is primarily due to a property common to all 5d materials: the large spatial extent of the ion. This allows magnetism to couple to phonons on an unprecedented scale and in general offers multiple new routes to enhanced coupled phenomena in 5d materials.« less

Underwater Threat Source Localization: Processing Sensor Network TDOAs with a Terascale Optical Core Device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barhen, Jacob; Imam, Neena

2007-01-01

Revolutionary computing technologies are defined in terms of technological breakthroughs, which leapfrog over near-term projected advances in conventional hardware and software to produce paradigm shifts in computational science. For underwater threat source localization using information provided by a dynamical sensor network, one of the most promising computational advances builds upon the emergence of digital optical-core devices. In this article, we present initial results of sensor network calculations that focus on the concept of signal wavefront time-difference-of-arrival (TDOA). The corresponding algorithms are implemented on the EnLight processing platform recently introduced by Lenslet Laboratories. This tera-scale digital optical core processor is optimizedmore » for array operations, which it performs in a fixed-point-arithmetic architecture. Our results (i) illustrate the ability to reach the required accuracy in the TDOA computation, and (ii) demonstrate that a considerable speed-up can be achieved when using the EnLight 64a prototype processor as compared to a dual Intel XeonTM processor.« less

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.

PubMed

Nagel, Zachary D; Engelward, Bevin P; Brenner, David J; Begley, Thomas J; Sobol, Robert W; Bielas, Jason H; Stambrook, Peter J; Wei, Qingyi; Hu, Jennifer J; Terry, Mary Beth; Dilworth, Caroline; McAllister, Kimberly A; Reinlib, Les; Worth, Leroy; Shaughnessy, Daniel T

2017-08-01

The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for treatment decisions for diseased populations, developing personalized therapy strategies represent an important dimension of both precision medicine and personalized prevention. In this commentary, we highlight recently developed enabling technologies in the field of DNA damage, DNA repair, and mutagenesis. We propose that omics approaches and functional assays can be integrated into population studies that fuse basic, translational and clinical research with commercial expertise in order to accelerate personalized prevention and treatment of cancer and other diseases linked to aberrant responses to DNA damage. This collaborative approach is generally applicable to efforts to develop data-driven, individualized prevention and treatment strategies for other diseases. We also recommend strategies for maximizing the use of biological samples for epidemiological studies, and for applying emerging technologies to clinical applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Gut Microbes and the Brain: Paradigm Shift in Neuroscience

PubMed Central

Knight, Rob; Mazmanian, Sarkis K.; Cryan, John F.; Tillisch, Kirsten

2014-01-01

The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. A growing body of preclinical literature has demonstrated bidirectional signaling between the brain and the gut microbiome, involving multiple neurocrine and endocrine signaling mechanisms. While psychological and physical stressors can affect the composition and metabolic activity of the gut microbiota, experimental changes to the gut microbiome can affect emotional behavior and related brain systems. These findings have resulted in speculation that alterations in the gut microbiome may play a pathophysiological role in human brain diseases, including autism spectrum disorder, anxiety, depression, and chronic pain. Ongoing large-scale population-based studies of the gut microbiome and brain imaging studies looking at the effect of gut microbiome modulation on brain responses to emotion-related stimuli are seeking to validate these speculations. This article is a summary of emerging topics covered in a symposium and is not meant to be a comprehensive review of the subject. PMID:25392516

When combination therapy isn't working: emerging therapies for the management of inflammatory bowel disease.

PubMed

Krishnareddy, Suneeta; Swaminath, Arun

2014-02-07

Although antagonists of tumor necrosis factor have resulted in major therapeutic benefits in inflammatory bowel disease, the magnitude and durability of response are variable. Similar to previously available drugs such as 5-aminosalicylates and immunomodulators, the therapeutic effect is not universal leaving many people searching for options. The development of newer agents has benefited from advances in the understanding of the pathophysiology of the disease. Uncontrolled activation of the acquired immune system has an important role, and lymphocytes, cytokines, and adhesion molecules are broadly targeted for therapeutic intervention. There is increasing evidence of an important role of the innate immune system and the intestinal epithelium, and the therapeutic paradigm is also shifting from immunosuppression to the reinforcement of the intestinal barrier, and modification of the disease process. In this review, we explore the limitation of current therapy as well as mechanisms of actions of new drugs and the efficacy and adverse events from data from clinical trials.

Planetary health: protecting human health on a rapidly changing planet.

PubMed

Myers, Samuel S

2018-12-23

The impact of human activities on our planet's natural systems has been intensifying rapidly in the past several decades, leading to disruption and transformation of most natural systems. These disruptions in the atmosphere, oceans, and across the terrestrial land surface are not only driving species to extinction, they pose serious threats to human health and wellbeing. Characterising and addressing these threats requires a paradigm shift. In a lecture delivered to the Academy of Medical Sciences on Nov 13, 2017, I describe the scale of human impacts on natural systems and the extensive associated health effects across nearly every dimension of human health. I highlight several overarching themes that emerge from planetary health and suggest advances in the way we train, reward, promote, and fund the generation of health scientists who will be tasked with breaking out of their disciplinary silos to address this urgent constellation of health threats. I propose that protecting the health of future generations requires taking better care of Earth's natural systems. Copyright © 2017 Elsevier Ltd. All rights reserved.

Optimization of sparse matrix-vector multiplication on emerging multicore platforms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Samuel; Oliker, Leonid; Vuduc, Richard

2007-01-01

We are witnessing a dramatic change in computer architecture due to the multicore paradigm shift, as every electronic device from cell phones to supercomputers confronts parallelism of unprecedented scale. To fully unleash the potential of these systems, the HPC community must develop multicore specific optimization methodologies for important scientific computations. In this work, we examine sparse matrix-vector multiply (SpMV) - one of the most heavily used kernels in scientific computing - across a broad spectrum of multicore designs. Our experimental platform includes the homogeneous AMD dual-core and Intel quad-core designs, the heterogeneous STI Cell, as well as the first scientificmore » study of the highly multithreaded Sun Niagara2. We present several optimization strategies especially effective for the multicore environment, and demonstrate significant performance improvements compared to existing state-of-the-art serial and parallel SpMV implementations. Additionally, we present key insights into the architectural tradeoffs of leading multicore design strategies, in the context of demanding memory-bound numerical algorithms.« less

Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation.

PubMed

Lee, Christina; Geng, Shuo; Zhang, Yao; Rahtes, Allison; Li, Liwu

2017-09-01

The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable of "memorizing" not only the chemical nature but also the history and dosages of external stimulants. As a consequence, innate leukocytes can be dynamically programmed or reprogrammed into complex inflammatory memory states. Key examples of innate leukocyte memory dynamics include the development of primed and tolerant monocytes when "programmed" with a variety of inflammatory stimulants at varying signal strengths. The development of innate leukocyte memory may have far-reaching translational implications, as programmed innate leukocytes may affect the pathogenesis of both acute and chronic inflammatory diseases. This review intends to critically discuss some of the recent studies that address this emerging concept and its implication in the pathogenesis of inflammatory diseases. © Society for Leukocyte Biology.

The RUNX complex: reaching beyond haematopoiesis into immunity.

PubMed

Voon, Dominic Chih-Cheng; Hor, Yit Teng; Ito, Yoshiaki

2015-12-01

Among their diverse roles as transcriptional regulators during development and cell fate specification, the RUNX transcription factors are best known for the parts they play in haematopoiesis. RUNX proteins are expressed throughout all haematopoietic lineages, being necessary for the emergence of the first haematopoietic stem cells to their terminal differentiation. Although much progress has been made since their discoveries almost two decades ago, current appreciation of RUNX in haematopoiesis is largely grounded in their lineage-specifying roles. In contrast, the importance of RUNX to immunity has been mostly obscured for historic, technical and conceptual reasons. However, this paradigm is likely to shift over time, as a primary purpose of haematopoiesis is to resource the immune system. Furthermore, recent evidence suggests a role for RUNX in the innate immunity of non-haematopoietic cells. This review takes a haematopoiesis-centric approach to collate what is known of RUNX's contribution to the overall mammalian immune system and discuss their growing prominence in areas such as autoimmunity, inflammatory diseases and mucosal immunity. © 2015 John Wiley & Sons Ltd.

An analysis of the phenomenon of increased parental participation during the child's dental experience.

PubMed

Pinkham, J R

1991-01-01

The role of the parent during their child's dental experience, in contemporary society, has changed during the past decade and should be addressed by pediatric dentists. Included in this matter are issues regarding risk management and practice management. Behavioral pediatric dentistry is in flux, much like the world that it serves; there appear to be schisms within the profession regarding one aspect of this: the presence of parents in the dental operatory. Presented here is an analysis of the paradigm-shifts in society since World War II, when a postfigurative parenting strategy was in vogue. An explication of noted anthropologist Margaret Mead's descriptions of this and two subsequent parenting styles, including configurative (or transitional) and prefigurative (contemporary) are presented. They are analyzed in terms of parental attitudes concerning trusting their child to authority figures, including the dental clinician. This emerging protective instinct is termed "social hypertrophy", based on social biologist Edward O. Wilson's work. Dentists are encouraged to understand parental attitudes and avoid unnecessary conflict.

Distance-responsive genes found in dancing honey bees.

PubMed

Sen Sarma, M; Rodriguez-Zas, S L; Gernat, T; Nguyen, T; Newman, T; Robinson, G E

2010-10-01

We report that regions of the honey bee brain involved in visual processing and learning and memory show a specific genomic response to distance information. These results were obtained with an established method that separates effects of perceived distance from effects of actual distance flown. Individuals forced to shift from a short to perceived long distance to reach a feeding site showed gene expression differences in the optic lobes and mushroom bodies relative to individuals that continued to perceive a short distance, even though they all flew the same distance. Bioinformatic analyses suggest that the genomic response to distance information involves learning and memory systems associated with well-known signaling pathways, synaptic remodeling, transcription factors and protein metabolism. By showing distance-sensitive brain gene expression, our findings also significantly extend the emerging paradigm of the genome as a dynamic regulator of behavior, that is particularly responsive to stimuli important in social life. © 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

Safety and clinical efficacy of everolimus in the treatment of advanced renal cell carcinoma (RCC)

PubMed Central

Shahani, Rohan; Kwan, Kevin G; Kapoor, Anil

2010-01-01

Renal cell carcinoma (RCC) is one of the most lethal genitourinary malignancies. Recently, there has been a paradigm shift in the management of advanced RCC. New targeted therapies including vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors have been developed which have shown promising results in a patient population who otherwise had very few options for treatment. The first mTOR inhibitor, temsirolimus, an intravenous prodrug, has shown improved overall survival in poor prognosis patients. More recently, an oral mTOR inhibitor, everolimus (RAD 001), has been developed which has been shown to delay disease progression in patients with metastatic RCC who have progressed on other targeted therapies. Although a survival advantage in phase III trials is seen with everolimus, associated systemic toxicities, while generally well tolerated, are not insignificant. These include mucositis, hyperglycemia, hyperlipidemia, and pneumonitis. Despite the side effects, emerging evidence points to everolimus as the optimal second-line treatment for patients with advanced renal cell carcinoma. PMID:21701620

[Molecular-Genetic Diagnosis and Molecular-Targeted Therapy in Cancer: Challenges in the Era of Precision Medicine].

PubMed

Miyachi, Hayato

2015-10-01

Elucidation of the molecular pathogenesis of neoplasms and application of emerging technologies for testing and therapy have resulted in a series of paradigm shifts in patient care, from conventional to personalized medicine. This has been promoted by companion diagnostics and molecular targeted therapy, tailoring the treatment to the individual characteristics of each patient. Precision oncology has been accelerated by integrating the enhanced resolution of molecular analysis, mechanism clarity, and therapeutic relevance through genomic knowledge. In its clinical implementation, there are laboratory challenges concerning accurate measurement using stored samples, differentiation between driver and passenger mutations as well as between germline and somatic mutations, bioinformatics availability, practical decision-making algorithms, and ethical issues regarding incidental findings. The medical laboratory has a new role in providing not only testing services but also an instructive approach to users to ensure the sample quality and privacy protection of personal genome information, supporting the quality of patient practice based on laboratory diagnosis.

Introduction to the special issue on diversity and leadership.

PubMed

Chin, Jean Lau

2010-04-01

Theories of leadership have neglected diversity issues. As the population within the United States and in countries throughout the world becomes increasingly diverse, the contexts in which leadership occurs within institutions and communities will also become increasingly diverse. Attention to diversity is not simply about representation of leaders from diverse groups in the ranks of leadership. Attention to diversity means paradigm shifts in our theories of leadership so as to make them inclusive; it means incorporating explanations of how dimensions of diversity shape our understanding of leadership. It means paying attention to the perceptions and expectations of diverse leaders by diverse followers and to how bias influences the exercise of leadership. Although leadership theories have evolved and reflect changing social contexts, they remain silent on issues of equity, diversity, and social justice. Theories of leadership need to be expanded to incorporate diversity if they are to be relevant for the 21st century amidst new social contexts, emerging global concerns, and changing population demographics. PsycINFO Database Record (c) 2010 APA, all rights reserved

CubeSats in Hydrology: Ultrahigh-Resolution Insights Into Vegetation Dynamics and Terrestrial Evaporation

NASA Astrophysics Data System (ADS)

McCabe, M. F.; Aragon, B.; Houborg, R.; Mascaro, J.

2017-12-01

Satellite-based remote sensing has generally necessitated a trade-off between spatial resolution and temporal frequency, affecting the capacity to observe fast hydrological processes and rapidly changing land surface conditions. An avenue for overcoming these spatiotemporal restrictions is the concept of using constellations of satellites, as opposed to the mission focus exemplified by the more conventional space-agency approach to earth observation. Referred to as CubeSats, these platforms offer the potential to provide new insights into a range of earth system variables and processes. Their emergence heralds a paradigm shift from single-sensor launches to an operational approach that envisions tens to hundreds of small, lightweight, and comparatively inexpensive satellites placed into a range of low earth orbits. Although current systems are largely limited to sensing in the optical portion of the electromagnetic spectrum, we demonstrate the opportunity and potential that CubeSats present the hydrological community via the retrieval of vegetation dynamics and terrestrial evaporation and foreshadow future sensing capabilities.

John R. Delaney Receives 2012 Athelstan Spilhaus Award: Response

NASA Astrophysics Data System (ADS)

Delaney, John R.

2013-01-01

It is humbling and exhilarating to be honored as this year's recipient of the Spilhaus Award. Humbling because Athelstan himself set the standard as a highly productive scientific innovator with a gift for making science not just accessible but engaging to the public at large. Exhilarating because we are all now poised on the threshold of being able to achieve universal scientific engagement with a global audience. Rapidly emerging technologies, global societal problems, shifting international attitudes, and novel social media are converging to power a new paradigm of scientific inquiry and engagement. Scientists are now enabled to operate transparently on a stage of planetary to microscopic scale. The boundaries between research and education begin to blur as this convergence embraces scientific investigation, the arts, the environment, the economy, ethics, energy, health, and entertainment. It is into this complex cultural tapestry that we scientists must weave our stories of struggle and success to engage entire communities in the essential roles that science, technology, and people play.

A Review of Pediatric Critical Care in Resource-Limited Settings: A Look at Past, Present, and Future Directions

PubMed Central

Turner, Erin L.; Nielsen, Katie R.; Jamal, Shelina M.; von Saint André-von Arnim, Amelie; Musa, Ndidiamaka L.

2016-01-01

Fifteen years ago, United Nations world leaders defined millenium development goal 4 (MDG 4): to reduce under-5-year mortality rates by two-thirds by the year 2015. Unfortunately, only 27 of 138 developing countries are expected to achieve MDG 4. The majority of childhood deaths in these settings result from reversible causes, and developing effective pediatric emergency and critical care services could substantially reduce this mortality. The Ebola outbreak highlighted the fragility of health care systems in resource-limited settings and emphasized the urgent need for a paradigm shift in the global approach to healthcare delivery related to critical illness. This review provides an overview of pediatric critical care in resource-limited settings and outlines strategies to address challenges specific to these areas. Implementation of these tools has the potential to move us toward delivery of an adequate standard of critical care for all children globally, and ultimately decrease global child mortality in resource-limited settings. PMID:26925393

Wearable medical systems for p-Health.

PubMed

Teng, Xiao-Fei; Zhang, Yuan-Ting; Poon, Carmen C Y; Bonato, Paolo

2008-01-01

Driven by the growing aging population, prevalence of chronic diseases, and continuously rising healthcare costs, the healthcare system is undergoing a fundamental transformation, from the conventional hospital-centered system to an individual-centered system. Current and emerging developments in wearable medical systems will have a radical impact on this paradigm shift. Advances in wearable medical systems will enable the accessibility and affordability of healthcare, so that physiological conditions can be monitored not only at sporadic snapshots but also continuously for extended periods of time, making early disease detection and timely response to health threats possible. This paper reviews recent developments in the area of wearable medical systems for p-Health. Enabling technologies for continuous and noninvasive measurements of vital signs and biochemical variables, advances in intelligent biomedical clothing and body area networks, approaches for motion artifact reduction, strategies for wearable energy harvesting, and the establishment of standard protocols for the evaluation of wearable medical devices are presented in this paper with examples of clinical applications of these technologies.

Combining Immune Checkpoint Inhibitors and Kinase-Inhibiting Supramolecular Therapeutics for Enhanced Anticancer Efficacy.

PubMed

Kulkarni, Ashish; Natarajan, Siva Kumar; Chandrasekar, Vineethkrishna; Pandey, Prithvi Raj; Sengupta, Shiladitya

2016-09-29

A major limitation of immune checkpoint inhibitors is that only a small subset of patients achieve durable clinical responses. This necessitates the development of combinatorial regimens with immunotherapy. However, some combinations, such as MEK- or PI3K-inhibitors with a PD1-PDL1 checkpoint inhibitor, are pharmacologically challenging to implement. We rationalized that such combinations can be enabled using nanoscale supramolecular targeted therapeutics, which spatially home into tumors and exert temporally sustained inhibition of the target. Here we describe two case studies where nanoscale MEK- and PI3K-targeting supramolecular therapeutics were engineered using a quantum mechanical all-atomistic simulation-based approach. The combinations of nanoscale MEK- and PI3K-targeting supramolecular therapeutics with checkpoint PDL1 and PD1 inhibitors exert enhanced antitumor outcome in melanoma and breast cancers in vivo, respectively. Additionally, the temporal sequence of administration impacts the outcome. The combination of supramolecular therapeutics and immunotherapy could emerge as a paradigm shift in the treatment of cancer.

Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street.

PubMed

Barrett, David M; Grupp, Stephan A; June, Carl H

2015-08-01

The field of adoptive cell transfer (ACT) is currently comprised of chimeric Ag receptor (CAR)- and TCR-engineered T cells and has emerged from principles of basic immunology to paradigm-shifting clinical immunotherapy. ACT of T cells engineered to express artificial receptors that target cells of choice is an exciting new approach for cancer, and it holds equal promise for chronic infection and autoimmunity. Using principles of synthetic biology, advances in immunology, and genetic engineering have made it possible to generate human T cells that display desired specificities and enhanced functionalities. Clinical trials in patients with advanced B cell leukemias and lymphomas treated with CD19-specific CAR T cells have induced durable remissions in adults and children. The prospects for the widespread availability of engineered T cells have changed dramatically given the recent entry of the pharmaceutical industry to this arena. In this overview, we discuss some of the challenges and opportunities that face the field of ACT. Copyright © 2015 by The American Association of Immunologists, Inc.

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease

PubMed Central

Nagel, Zachary D.; Engelward, Bevin P.; Brenner, David J.; Begley, Thomas J.; Sobol, Robert W.; Bielas, Jason H.; Stambrook, Peter J.; Wei, Qingyi; Hu, Jennifer J.; Terry, Mary Beth; Dilworth, Caroline; McAllister, Kimberly A.; Reinlib, Les; Worth, Leroy; Shaughnessy, Daniel T.

2018-01-01

The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for treatment decisions for diseased populations, developing personalized therapy strategies represent an important dimension of both precision medicine and personalized prevention. In this commentary, we highlight recently developed enabling technologies in the field of DNA damage, DNA repair, and mutagenesis. We propose that omics approaches and functional assays can be integrated into population studies that fuse basic, translational and clinical research with commercial expertise in order to accelerate personalized prevention and treatment of cancer and other diseases linked to aberrant responses to DNA damage. This collaborative approach is generally applicable to efforts to develop data-driven, individualized prevention and treatment strategies for other diseases. We also recommend strategies for maximizing the use of biological samples for epidemiological studies, and for applying emerging technologies to clinical applications. PMID:28458064

Wide and ultra-wide bandgap oxides: where paradigm-shift photovoltaics meets transparent power electronics

NASA Astrophysics Data System (ADS)

Pérez-Tomás, Amador; Chikoidze, Ekaterine; Jennings, Michael R.; Russell, Stephen A. O.; Teherani, Ferechteh H.; Bove, Philippe; Sandana, Eric V.; Rogers, David J.

2018-03-01

Oxides represent the largest family of wide bandgap (WBG) semiconductors and also offer a huge potential range of complementary magnetic and electronic properties, such as ferromagnetism, ferroelectricity, antiferroelectricity and high-temperature superconductivity. Here, we review our integration of WBG and ultra WBG semiconductor oxides into different solar cells architectures where they have the role of transparent conductive electrodes and/or barriers bringing unique functionalities into the structure such above bandgap voltages or switchable interfaces. We also give an overview of the state-of-the-art and perspectives for the emerging semiconductor β- Ga2O3, which is widely forecast to herald the next generation of power electronic converters because of the combination of an UWBG with the capacity to conduct electricity. This opens unprecedented possibilities for the monolithic integration in solar cells of both self-powered logic and power electronics functionalities. Therefore, WBG and UWBG oxides have enormous promise to become key enabling technologies for the zero emissions smart integration of the internet of things.

Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?

PubMed Central

Girgis, Christian M.; Mokbel, Nancy; DiGirolamo, Douglas J.

2014-01-01

Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)— both in normal aging and pathologic states—can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the prevention of such fractures has focused solely on bone, but our increasing understanding of the interconnected biology of muscle and bone has begun to shift our treatment paradigm for musculoskeletal disease. Targeting pathways that centrally regulate both bone and muscle (eg, GH/IGF-1, sex steroids, etc.) and newly emerging pathways that might facilitate communication between these 2 tissues (eg, activin/myostatin) might allow a greater therapeutic benefit and/or previously unanticipated means by which to treat these frail patients and prevent fracture. In this review, we will discuss a number of therapies currently under development that aim to treat musculoskeletal disease in precisely such a holistic fashion. PMID:24633910

Targeted Therapies in Non-Small Cell Lung Cancer—Beyond EGFR and ALK

PubMed Central

Rothschild, Sacha I.

2015-01-01

Systemic therapy for non-small cell lung cancer (NSCLC) has undergone a dramatic paradigm shift over the past decade. Advances in our understanding of the underlying biology of NSCLC have revealed distinct molecular subtypes. A substantial proportion of NSCLC depends on oncogenic molecular aberrations (so-called “driver mutations”) for their malignant phenotype. Personalized therapy encompasses the strategy of matching these subtypes with effective targeted therapies. EGFR mutations and ALK translocation are the most effectively targeted oncogenes in NSCLC. EGFR mutations and ALK gene rearrangements are successfully being targeted with specific tyrosine kinase inhibitors. The number of molecular subgroups of NSCLC continues to grow. The scope of this review is to discuss recent data on novel molecular targets as ROS1, BRAF, KRAS, HER2, c-MET, RET, PIK3CA, FGFR1 and DDR2. Thereby the review will focus on therapeutic strategies targeting these aberrations. Moreover, the emerging challenge of acquired resistance to initially effective therapies will be discussed. PMID:26018876

Targeted Therapies in Non-Small Cell Lung Cancer-Beyond EGFR and ALK.

PubMed

Rothschild, Sacha I

2015-05-26

Systemic therapy for non-small cell lung cancer (NSCLC) has undergone a dramatic paradigm shift over the past decade. Advances in our understanding of the underlying biology of NSCLC have revealed distinct molecular subtypes. A substantial proportion of NSCLC depends on oncogenic molecular aberrations (so-called "driver mutations") for their malignant phenotype. Personalized therapy encompasses the strategy of matching these subtypes with effective targeted therapies. EGFR mutations and ALK translocation are the most effectively targeted oncogenes in NSCLC. EGFR mutations and ALK gene rearrangements are successfully being targeted with specific tyrosine kinase inhibitors. The number of molecular subgroups of NSCLC continues to grow. The scope of this review is to discuss recent data on novel molecular targets as ROS1, BRAF, KRAS, HER2, c-MET, RET, PIK3CA, FGFR1 and DDR2. Thereby the review will focus on therapeutic strategies targeting these aberrations. Moreover, the emerging challenge of acquired resistance to initially effective therapies will be discussed.

In Vitro Models of Human Toxicity Pathways

EPA Science Inventory

For toxicity testing and assessment programs to address the large numbers of substances of potential concern, a paradigm shift in the assessment of chemical hazard and risk is needed that takes advantage of advances in molecular toxicology, computational sciences, and information...

Carrots, Sticks and Fog During Insurgencies

DTIC Science & Technology

2012-03-21

an asymmetrical counterinsur- gency situation where the civilian population plays a major role. Consequently, legacy warfare and combat models (e.g... Lanchester models (Washburn and Kress, 2009)) must be updated to reflect this significant shift in conflict paradigm. In particular, the increasingly